<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5C3</accession>
    <name>A0A9Q0L5C3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_13442</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5C3"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="11">
        <location>
            <begin position="426"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="639"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5066587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="758" mass="89235" checksum="7B8A4B6A4877AD91" modified="2023-09-13" version="1">MSFQIKIPQKINKNQQNKTLFGKINFKKKEKEEEEEEKKKFLTRNLFEKFGNEENIKSKENIEQQLTKKPRIRQKTPTFKRRTSLTISLSQCEEISPNPNPKEPLTADVNKSSPLFKFESTPKTLKAPKLFRATQLSRSKSISQDIFSHPKTPNTPDQSSNISSLIYESPNISTKLSKLAINSNQKTPKINREESIDEDIDEEVDKINQTNYEFDPISNFNKNFNKNFNSNFNKPITTKLSIKTDIKENLKEEIIKNGNESDECPKTPDGSKTKTDLFYSKMIRSPSAGFLDATTPSKLLNYGIRNERKCITPEITESPNQKTCCFMFKSNSLDENQIENQNQNQNQNQNQNENENQNQNEYKRKPTGFLQKQKSMGMNLNYEINSPKLFLPITRGEPYDLSTISGSTVCKLVNGDYKDTFDYTFIIDCRFPYEYEGGHIAGAHNWNIPDLVLKKLFCKQIYRKACVIFYCEFSQKRGPEMARLFRRIDRSINQYPDLFYADTYVLEGGYRRFFHNEENKGFCIPRDYREMKDKKFKEQLSKDNKFRREAIKKLKKKRTISLQELKSWYGELMGEKKPQSQARLKRGNSISISSNAIRKFGFSFSQPIFNQEKKENEFEMLRKVSTDFGQEFLYSNQNQKENQNQKEKENQSQNQNQNQNQNQNINQNQNQNQNQNENENENQNENQNENQNQNQNQNEKEKSKSKIKMKMKIKMKIKIKIKMKMKMKMKMKMKIKIKIKIKSNSNQIENEKENQNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5H9</accession>
    <name>A0A9Q0L5H9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5H9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="227" mass="27350" checksum="E4258CFEE2C54FBA" modified="2023-09-13" version="1">MNKNDKFVLFIDVKQNEMKSFYEMKMMIDHKFSESNNNNNENENENNNNNNNNQNEIEIENENLIISKGKSCYVIFIIHLLPNYKKKFNFSFNFEKNWEYSYQDTFTKEVEIPNPNLTESIDYFEELKKFGKLKSICEQMMIDKISKELIERLFCEESGYQKFTFVNHLKKQKLIYLTLEENINEKNVIFVGKRLRADQTHFQKYEKGIFKNTGKKLKIFSKNLENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6P7</accession>
    <name>A0A9Q0L6P7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinitis pigmentosa 1-like 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1565"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1702" mass="202901" checksum="5327143BEB3CE1BB" modified="2023-09-13" version="1">MNQKEENKNSEKKKEEEKQNQQEKENKEKDEEILNPEEEEAFKKFQNRIFLISSSFASSTAQDFNKTTSEFITIIDSDFKQENSFLKKKENFLEETFLNILQIIRKRTFNFSFSNDIQLLYQKSIQFFLHKIQNNKINQTILSLMITIYSDEMYMFESVKYLIEKDENYRKKRFQYQSIPKKIRKYDEKNQKYTRLEENNNKTSLFYIENIQNFGINGGFRIINEILSKDLKEENHKINFELFFLFSKIYYLMLQYLTPVVFELYLKEFVQIGFSFIEIFWKTPENYNLLYKTTKNTLSVILYIMEKTPSIPEVEPKIRTIEFSLKLIEKFIQNEDIKEQQKGIKMILETIRDIENLKKRSENDSYSRSDRKKYEKQYKIAGNSLVGWLKKEKVLEKQFQTETKDYNHLLLLNEIIKFHGAIEPISNELINIIWKLLQQDLSTNLRLKQVLTQNMIAITTVATSSQANDLNEKIQKVKKEAYDINFIELMSKVTIKKLSKNPKNIRKLFGMETLWSLIQDGSGISTSVAARVKTNLKNILSKKECKNVLDFYISSCIQNIKNHKSVSLSLQLIRDILSNFAQEIDQKDIKNISSSIKNLEKKQSVLELFFRDFEYYHKKAKEKAKEVSNLRNELVSDLGFQKGGKEKENQKEKENQKENQNQNQNQNQNQNQNQNQKNYVEFDISTTPIVGAHPHLEEIEQRLKFLHFILAFSETTLSFQQFNLLWSLLIEDALSKLEEDSFFQFIRSINLNSTKYGKAFELPVLEEIFEKKIVHFVHPKMDATQYSIFQQFFYGINSRLNKMIPEIQIVTYQTLAQPSTFSFFKGTESGGKPKVVTKTSQRPTGNFLIETTDLKHLDFLWKIVLDSENEEIATQSKNILSNLYLLLSPSLLKKPESRKNVQEEFISQVMKKISEILKAKEKNPEDQERMKRCLSLLHSFVEFFDKQKGLDNLENPALEPHQKRLQNEQILIEIFHNKSKQLIPIYSSFTVQEMKEFIAKYLNLQPENFQMYIYKREITGDEKPIRNFHIYNFSQILIHDLKKEEPPKKPTQNNENQNENQNENQNDDDNNNDDDEENQKKTDKNSKEQKMYEKFLKNERKKKQEQQKAKEDFEKRQKSQLEARKKEVEEKLRKEKEEREKNKSDRFPAVVLSRLENFQILLQLLDYSPQIGLLTWKLIQQLPTNHRLLFRFSSLNQSKLLYISQKQAYDHYFSDFQFIEQDKNKVFVDKMISEEKPISEFFSKDNFFELLYSLQVIQQLLLVNKEESFEFSQKTGNLRDEHWCSSFITNNGISRFMEIIAFINSKLQPEIKQKILTKEDSEFIQGDIQFWDKEKLKEKEKENYNQNYNEIYNYNDNENEQDQDLFLNLHPKLFESLTLLMKVFIFIISQNPFQKTKSPLCTEFEKQLTHDQSSLDFQKFLDSLFELMILFSQIANNPNTPSKIYSEVGSFFEYAILMIEIFISHDPNIISQFFSTPLLKLPRFIKRSLLNLNSKIRVATQHLLIVISHRLLEKEMIFEDTNFGKFLFMELLSLLPNIERYGKFSREYFYVINAIISFKIENKDENKDENKIENKDENKIENKDENKDNKEDNKDNKDEKDENKDENKDENKDDENKIENKDNKDENKDENKDENKDENKDENKDENKDENKEDENNKDNKDENKDEKEDNKDEKDENKIENNKDEKMKKITFIQFSKFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6S1</accession>
    <name>A0A9Q0L6S1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exportin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6S1"/>
    <dbReference type="OMA" id="QMSFIPG"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1030" mass="121236" checksum="9D6CF5AD6C664D1E" modified="2023-09-13" version="1">MNFLKENEQFNLDLFDSIVQIFYYGKENEKQNAHQMLIDFQQNQLSWKYVDLIIQNSNSQESRFIALNILENAIKFNWESIETSDQENITNFIIELTSQILENAETKESNKLLLNKLNLILIEILKKQQTQDLLLQIISQSSSSPLVYENTIIIIQLLLEDVFEFSQKELTNDSTKILKEQIKTIQFEIFKILTEVLIEFSQINNFEEENHLQIIQVVISLLSILFREVSPENIYQMNIIDQISINYLQEPKTSYISMKFLADISGIKSGFEFKEEYIKLFVDTTSSLMKIFQQNDLNEIFKHGLDEDHFFLKNIAIFLSKTLQAHFNLLFQQDSLFDLLHFAHDLLLNLTIINEEDSEMLTICFEYWNFFMNILSSNNAKFSIEKINSQNHLNLYNEIVEKLRELTINYMQLPSEIHLENPDEEDFTTEIQSNDIYSFMSQTLICIWKIQPQKTLDNLTQKLSNEISNLHQQNYQQITPFNRICRSISSIGKALPSTNQSSVFLTQIFSILMDLFKKCPVKNIRPIIIANILVIAAESTTFLNSSPKFLKIIINKIFQFMGKSHHELSQISCQAFSNISKRCNKQIVKQEFSEKTPFVFSIISQLNQVVSRLNQQQQQICFQSIGKIISVAPNNFKQELISNLFQNINQHFLQLFLPIQNCSKNPNKNDILHLFSGNFTEEILFILKINRSVSKTSHVSFRNQFAQFSENYLLIFQSYSSFFSSIHFDPKMTKLMNNDILTQIRLIKKEILLLFISVITHNLQTDDIDEKFLNTILDILTQDYKYNIENQNRPPEVLNLIISIISKLKSKATNQIPRIFAYVFDSTWLMIGNDHEQFPEHRINLYSLIYKIIKYCYHFFLVLNQDQFAKIIECLIWGMKHIHHLISRLGLKSLHLLFQKISSQSENAGNFYQQFYLVILNELLIIIFDTFHKQTIHNQIQFLQHLIHLVNHNKILVTLFPDFSDSYDQNEHFVKDFIFNFLKSNFPNLKESQSLLFIEQIFIQNRDNLSTPLFENLVIDFLKEIKKFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6T2</accession>
    <name>A0A9Q0L6T2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6T2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="243" mass="28993" checksum="22518F8034F5E2D4" modified="2023-09-13" version="1">MLIENENENPKRKLYSCGDSKQNGLNKNEDTREFTEIKSYLFENDDNILDFSVGYHHTFILTKKGKLIGFGYNYYSQLGTGDIKWNQSIPIQIELPKLRFNEDISNYHVYCGYENSFLYYSSSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQNKNEIEKLKEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6W3</accession>
    <name>A0A9Q0L6W3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6W3"/>
    <dbReference type="OMA" id="LWHEKAF"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="134" mass="15391" checksum="86DD57256ECE4F31" modified="2023-09-13" version="1">MEEAEQREQECISFVNSGNPEAALSVALANPFYKFPEQEKLTKQQKKELDDLTKQIKTKNFETAMNVLMAIQEKSIKSSIDKLNQEEINLLMKFIYRGLEYHQHSSTLFKWHAATLEKGGIGCIVRAIADRNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L706</accession>
    <name>A0A9Q0L706_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000140">
        <property type="protein sequence ID" value="KAJ5066570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L706"/>
    <dbReference type="OrthoDB" id="533331at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="252" mass="29980" checksum="DB0C1D11A3BA8113" modified="2023-09-13" version="1">MIKSEPIFNFSKQKVKFPKIQIYLKYPIFPKRNQNQNQNQNQFLEETDLLTILIQLEIFCEEKSIFDQKFKLSEKEKIEQKQCLLKIEGLKKQLESKIQTSTSKWMKKKKLEFLFPNLATYVSNKIFTSNSYDLEEYLSQMSLLNQIFMLCIDLKENLLLKNHSFIPKKISLLFSLLNESGGFKKEKEMIQKEFHLIKSLIQNSAENSFTIMNSAYSKWVQDLCDQIIENISKFPKEVIRYSDKMINFFSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7Q6</accession>
    <name>A0A9Q0L7Q6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein yippee-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_03289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7Q6"/>
    <dbReference type="OMA" id="CGGAAYW"/>
    <dbReference type="OrthoDB" id="434519at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255">
        <property type="entry name" value="CEREBLON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255:SF3">
        <property type="entry name" value="SULFITE EXPORTER TAUE_SAFE FAMILY PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="942"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="721"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="766"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1080" mass="122866" checksum="1A0725005419FDB3" modified="2023-09-13" version="1">MNDSIHFSGLFIVGSILIAFFSLLAAGAGIGGGVLFVGIFYLVLRLSSTEAVPLSNFAIFGGAITVLFVNARKKHPQANRPLIDYDIALLSQPMTLAGTVIGVLANVLLPEWLDEGLLFILLLVISYQNQNENQNQNENENQNQNENQNENQNQNENQNENQNQNQNQNENQNENQNENQNENQNENENENQNQNQNENENQNQNQNQNENENENENDKLSSNSNDQVFKIKNSNWMDFEEFDEDDNDSDNDETKGLLEKNNENNNENNNENNNENNNENNNEKNNENNNENQDLYQDIYQNRTFLDFDEFQIEQPRLRPNLHFSSDQEIEKMKKSEEKIGSQRLFLIIIVWLIIFVISLAKGGNSKESLVGIKKCSPSFWVVMFLSVPINILLTIYIGKLLLNKTQKKERIDFPNLKGDIYWRKVMIFGFSVVCFLNGFLAGMLGIGAGTVITFVLVEMKVEPQVLTATTALVVLFTSASTSIQFLILGLVPYAKGFWFFGITFIAFPIGKIYLNYLVKKYKKAALILFTFAIAISISTILMCYNTINAFRNGKHRKISDFSGAGVGGGVLFVGIFYLILTLPSTTAVPLSNFAIFGGAITILIVNYPKKHPQANRPLIDYDIALLSQPMTLAGTVVGVLANVLLPEWLVISTLFLLLIIIGYRSTLKAFRKYKLENQERKKELELKQKLKNRKELNGSSLNQQINQVNDESVNLEEIDFSKQRSEIGENSQKNGYSENESQNEFVTEEVSTDYWKEIEPDQSLNTEDNNNENNENNENNENNENNENNENNENNENNENNDKNDKNDDNTKKEQFWIDINYDQLENEEKQLKPNSDLDKDIQIQKIMRSEEKIGFKRLFLIIVVWLITFIISLVKGGNSKKSLVGIEKCSPSFWVVMLLSVPIDILLTIYIGKLLLDKKKKKEQINFPNVKGDIQWRKKVIFLFAIACFVTGFLAGMLGIGGGLIISFVLVEMKINPQVLTASTAMIVLFTSSSTSIQFLILGLVPYANGFWFFGITFIAFPIGKIYLNYLVKKYKKTSLILFVIAIAIWVSASVMLYNSINSLMHLKHEDKMSEFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8A5</accession>
    <name>A0A9Q0L8A5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8A5"/>
    <dbReference type="OMA" id="APYDGDM"/>
    <dbReference type="OrthoDB" id="188207at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040313926" evidence="6">
        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="424" mass="46186" checksum="D19B3AC84AD1F44E" modified="2023-09-13" version="1">MQKVIKLIFLLLALNLAYGAQQTGIFKPKTTTIGAMFGFSTAISDKYSIIGAPFTNRTGNSEGSAYIFEYQNNQWIQKTEFSPQNSNIENFFGFSVAIENPYVVIGSPSNNENGPSSGCIYVYNNTNDTWSFQSQVFPNDGQIGGHFGYSVDISGTQMIVGSYGTNESGLDSGSAYIFQLNGIVWIQQAKLVPADLNSGDYFGFSVGISNEYAIVGAPHQSLSGIDSGAAYLFHKNGASWVQNSKLIASDGSGYDRFAWSVAIDNSYAVVGAFYHQDHGAAYVFQNQNGIWTQSQMLTASDAFDLDYFGRSVKINGDFIVVGADGRTDNSVVDSGAAYVFQNSNGNWIQSAKVVASDAKDNWYFGYALDLSDNQVIVGAYGADNDGYLTGEMFSYTDFGLHHSTASSFMFSSLLLLFSIFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8F1</accession>
    <name>A0A9Q0L8F1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin cytoskeletal 2a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8F1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="383" mass="44441" checksum="078D2460DF7D4928" modified="2023-09-13" version="1">MEPIDLKNYFGDEIPSIFVIDNGSYSLKAGFAGETIPRFEMPNIIGKMNHKGLKSKKQKNIIGNECYSLSSFIELTETFENGKIKNWENMEKIWNHILFDELKIVTEESLGLITESPLTPKANREKVVQIIFETYNLRGFYYLITAQACLYSIKKPTAFIIEIGKSCYLTPVYDTYCLPHATQILNIGGDDLTKYLGNLIFQNQYSSFQSKISFEYQLLQKIKEEFCYVALDLNEETKNFEKNPENFEKTLEISNDKNFKIGKERFLVPEILFNPSIINRNSPGISSLILKSIERCDIDIRDDFYHNIILAGGSSLFPFLENRIEKEIRCFFPDAQVFALENRENLVWKGASMYARSQTFFDKCYTWEEYQESGPSMIHVKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8L8</accession>
    <name>A0A9Q0L8L8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_12279</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8L8"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000004">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="249"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5068421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="458" mass="51063" checksum="7B08AE5353D6497E" modified="2023-09-13" version="1">MPREVVSIHLGQAGCQIGTSCWELYCAEHGITYDGLMPSDTTKGQETDAFNTFFSETSAGQHVPRAVFFDLEPSVVQEVKNGKFRKLFHPDYMLTGKEDAANNYARGHYTVGKEYLEDAIDRIRKIVEQCSSVQGFLLFNSLGGGTGSGFGSLLLERFASDYKKKSKLDFCIYPAPQVSTSVVEPYNTVLSTHSMMDYCDVTFLVDNEAIYEICKQKLGIERPTYVNLNRLIAQVLSSITASLRFEGDLNVDLNEFQTNLVPYPRIHFPLVSYSPIINSKRAAHEAMTVNELTSSVFDPGSVMIKCDPRQGKYMACTMLYRGDVIPKDTTAAIANIKTKQNIQFVDWSPTGFKVGINKRPPSVVPGGDLALVKRALCMLAATTAVGETWNRVNHNFDLMFAKRAFVHWFVGEGMEESEFKESRDDLAALENDYEVAGKDTDELEEMSDGDDADEKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8S5</accession>
    <name>A0A9Q0L8S5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ndr1/hin1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8S5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040212303" evidence="3">
        <location>
            <begin position="17"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="842"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="960" mass="110759" checksum="92209802669051E8" modified="2023-09-13" version="1">MIIILILLLLKVENQTFLTDGCISLEFSPENGFGFSNSEMQINISISEKSKIKTGAGFSNLSDYSNEDSKFLTDLLLGIPVFYADHSIFLLDLNSSEIIVPNEATNYETNNKIGVKFINLEMNHLFELFTSLRIFDSETTNQHHSIEWTGFIQYSTLPLLLDTITQPNPPNFCSKFTELNFTIQDKKPKQNYGLQEIIVNYINNEEWILEITADIDISDSFPTEKKIIIKKFEVNSEEYSLENEISMNFLINGEAEIIVPIMKAGEHENLIEYTEGNSPEGVETIQQEITEKRAEMIFDLHKEGSFNLEIFDMNLGYFRPLEIGDPESVEEVYQSGTYWLGKFTNKTDNDSIIYLSFSIGEYRSNKSWFYYKEPEVHGVNCPMGSLRNMMCPFCQNGQLHMLGVDLTTIFSSYNFSLQDRIVDQNKSIDFSIGSQFNSSFNLSSEPFYQDQYVNISVLNFDEIVPNFKSIQNDRLFVENYDLYDSMDRNNLSRWRFVNQQYFNDSLDSIGVLMDVFINQNDFCMQEQGSGLKFSASYFVHNNFDNITVKKIENFNTNLWNNSVVQRIRFGSDNQSLVFQPENVGSMSLLFATIEFQIENNGEVSGMIVGYLSCNNSDLVINPDNPKQMNISSNSKSSLVFEVDYESSLDEDAKIECELDISQNSLPLWNITYENETVNGLIIPIYNGCLFQRADPYFPVDGISGIQVDNFDTNQESNENSFQLKFLVKINNSPVSVVFSLDCFINSSLILHETNSINFSQSEIQKYVDWIVVFESSFEYPFSIQCEIESEIEMESCWSNNSKFSNSSFDFLFQIQQDQEDSSGFWNSKLGSFLYKMGGDSKLGGVFCFIFFLLLFLTLLIFVPLFLLFKSKKKKLFQNQSKDFELKKVKNENLQKEFEMDQVVENPLKKKREKMKDLEKNADELLSQIGIEEEEKKRNKKSGLTLKEKMERDFDSIINQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8U3</accession>
    <name>A0A9Q0L8U3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8U3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040142385" description="Fibronectin type-III domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="907"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="108"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="165"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="223"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="520"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="962" mass="105909" checksum="D91A0A479460E246" modified="2023-09-13" version="1">MKKLIFAFFCLILIFQCLSQLETNKNNKNKENKNENEMKINPLKKSYKWEEIAELIANDGKSNDYFGYCPKILQNIIVVGSAYSTIGENEYQGKAYIFRNNGTNWNQEAELIASDGKSNDYFGYSVSIASSDIIVIGAYKSKIGNNISQGKVYIFRNDGENWNEDQILIASDGKSNDYFGYSVSIASTNTIAIGAPYAEIGNHMNQGKVYVFQNNGTNWNEYGILISSDGAKSDNFGYSVSVSSIDVIVIGAPNAMVGSNSYQGKVYMFQNNGTTWDEEEIIIASDGASYDNFGYSVATSQTEYFAVGAPYAEVGANFEQGKAYVFQNNGTTWNEDTILVGNEGASGDLFGYNLGKAYVFRRTQDIWNQDSILFASDGEAYDRFGYCVSISGEYSVSGAPYAEVGNNTQQGKAYVFEAFEVPDPVQLINCTSLFSKFGCFWYEVESLVDLQYQIIYNFTWNLVQYPILNGDVYYQEFNSSFYPDITGNQDYQIQIKACNISSSLCGQASNQWNLTTRIDSVKNFSLSSSSGESIQISWMFPDVPVIDSVPKLSNYIISYKQKSEIEPINITVSKLSTSYILHNLQSLTNYFVAIWPCRTGDCQGEDQGEIVSSSISTPFGPVLYASCSVSNIYNVFCSWTRPNASISPIYYNFTYKSSIVNDSGSFKPQSASQSFEVKFSNIDYFINISACDINDKCGTVTTIPITSGQLSAPTIDESIGKIESIELSFTKVEYSQGYIVSSDNGESWNNFSSLDLNGTNAIGIESNLAGNVEYQVCVKACSEPTCNPLFAGATSSTISIIPKLGNITSLRCFAKVCGFECSWDPLILSEGLKGYSFNYNSTLICLSNINTSQSITNLSCGSMYEISVFSSAGENCSFSNYSGVSSTAIITTLTNHKSSSSSHKKTIVIAIVVPVAVIVISIIIIAVVLIKRRISIKKKISSVINSSDENEKQNLLNDSKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L980</accession>
    <name>A0A9Q0L980_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L980"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="27253" checksum="AE5E937319499A82" modified="2023-09-13" version="1">MDFFGNFLDPQSILAQSELVPVKLLIDLPQLSQFNSILSSQSDSLFEIDFTETETETETETTEMSKIYFDSTKQKSPKIYLPLWIAIPLHQQKAVQIQMPYNFSNTFHSIWKSDSTSIKLQKIKRHFYTTGAILAQIFNDENLIDSMSQMLIKRFLKISDLADEPKIEQKDLITSQVTTDREEFIDNLDWLEQSLFQIGKQNSKQYQIWKNRASHKIQQSNVSVKTLKRFRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA51</accession>
    <name>A0A9Q0LA51_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fas-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_11883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA51"/>
    <dbReference type="OMA" id="CLNYLQM"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="8">
        <location>
            <begin position="337"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="278"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5069127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="417" mass="49489" checksum="A12988F18434C61D" modified="2023-09-13" version="1">MDSKQKLIDSLKELTGLGDNFCQNLLEKHNWNIQEATNDFFRNSIIDDSNEDQNQNQDEDQNQNQNQNNQNNNDNNDNNDKNKNQSMEIEKENSQNVFKKLFSNIMDKIQFYATESSNFPQYLNQKYGKDHPNFFEGNYQEAVNYAKISQKLLFVYLHSDPHFRTPDFCKNILYDNQIVDILNNDFVCWGAFVQQEQGFRISRMLEATTYPFIGIICFIPEAQTLWKSLEGDFTKEDLLKTLQSNLEKFSVEIAVRRYEEEQAQESKIIRENQDKEYYQSLILDQEREREELRELEQKKQKIEEEKQKKIAEEQKEKDKKEMLETFKKRLPKEPTENNQNTLTIAIKLPDSSRIQRKFLKTDTLRDLYDWVQIKSPDLIGNDFELAKNFPTTHFQNNETSLSSAGILNFDMLYLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA61</accession>
    <name>A0A9Q0LA61_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein kinase unc-51-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA61"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="314"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="396"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="492"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="549" mass="65037" checksum="578AB3376B16207B" modified="2023-09-13" version="1">MKKLKNKPKKKSKSFLFKRKNFKATKNIGKGSFGKVYLGRTLDNNKECAIKKIFLGKIKGLNVRRSTQLEIEIMKQVHHENVIELFFVEPENFINREVMEVFVIMEYCDMGSLRTYLEDKKNKKELIPIEEIKEIFTQTVRALKYLYDQRIIHRDLKPANILLKKDPKSKFGYTIKVCDFGLSKQIKEEEMKKSLHLMSTVGTPSYMAPEVLLHESYSWKADFWSLGAILYEMLTGNAAFKIFLSKNLKKQFKKVTVKSLPKKFLKKYPKECNDLVQKLLTVNPKQRISREELYKHKFLNNALDDLSKDISLERKKQIGILKSDYITNNEKEISLKKGEYVEIIAQLNEKEFRIKFQEKEGNIPIYFLEIYEEIGFNEKQEELFKIIQKKADKIREGKFIAIAKWDFSKSEEREIALKKGDCVEIIEIKEEGWFIVKLLGKEGYCHFDFLYFYEKIENPSNNKEDKIFSIDDETIIFNDEIFGGKDQIKRVIKRKKMVAMKDYEAQKQDELSFRAGDVVQITFKNYEEWWEGIINNQKGYFPITYFKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAK2</accession>
    <name>A0A9Q0LAK2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAK2"/>
    <dbReference type="OrthoDB" id="7327383at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="515" mass="60168" checksum="9CB797CD8B845B09" modified="2023-09-13" version="1">MLKKQKKTSKIESETESDSNSENESNSENENENESESNSENEDENEIENENENENENIPVIKKQTQTLFQDLEKMRKNQNKDADWIITVGESKRQFPCHKNIVSCRCPYFCKLSKENNQKEFIFKEINEQAMEEILRWIYTEKIDINSKNWIPIFNCAYQFELTPIFSLINAHGFTTIENVIDVYNFPDDIFPGLIQKCEMIIQKNFGSLLESEKILDFSQDKLMDIMKIGTKNHEFKDYPKLFVVLEKWWLRNNKFKIGDHHQDSSFNSQMKGFFHHIEKNIKTNITSKQIREMISQQVISGDLITQLQQIFIESKNNEEKKIAKTFAKSQIVRYYKQINSLTKWITRYSSVSSLKLQFRSHKGQAKYNFHEVCDDQGPTLVLIKTTRGFIFGGFTEVGFVSDKSKWIDSFDDGGFIVDPNAFIFTLKNYDLKFGETKKFLRNDDEKFALIYKNDLGPCFSFDFIIGQDLKSGKSSFGSSFKVPKGLVPCSEDANNYFSAGEIWEAELMEIYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAQ3</accession>
    <name>A0A9Q0LAQ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Straightjacket isoform c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAQ3"/>
    <dbReference type="OMA" id="MDCTITA"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="94"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="457" mass="51658" checksum="0FE04D71C1543888" modified="2023-09-13" version="1">MFAISSGAKDTTNFRLNLQQSNSFDKSSITYHGLFYEYYFNTGKPETEKTVAVEPFYAVTPNIYTNEKEYYISLALKSKYDGEGIKKFGRSPLNCVIILDISGSMNSPFYGRDDGEERSLSKLEVAKRTILGLFSHFHDTDYFGLVLFDTSAYVAWPYTQWGKIDKSKLEKKVKELRTKGGTNMEVGYNAGADMIRKYLKEEKDSERLKLCENRVMFLTDAHPNSGATSPQGLFSLTKKNADDKIYSTFIGVGVDFNTGLIDTITNTKGANYFAVHSSSEFKRRMETDFDYIVTTIAFDLKVKVDGAKILGAYGSPDADPNKETTVTEMCSVMPSNIENNETQGGIFLLKMDPSVADGIPVKITVSYQDRFGENHTDVHTTSFPELPDDQSTLFQDSSVRKAIFLVRYVDFLKEFTRNDENLKKGKQLLDYLNKEIPEIGDDKLKREVEALQKILDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB01</accession>
    <name>A0A9Q0LB01_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB01"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="138"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="315" mass="36853" checksum="F10F77A0F3871A25" modified="2023-09-13" version="1">MNAKQRLFHSFFSLFDKDSISKQVFSQLKQFNFFLPKSFLINLEKKIGKENEEKDKKIKTFESETHKLKKENQDKNKEIEDKNKEIEKKDKILKQKEKENKDMKPIFDKYRDQYQKDLEFEKKMEEIKKNFPQFSDSRIIKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLIIIKTKQNFIFGGFTQVGFKHSNGEYSNDSNAFIFSLRNDKGDRIPAKFTIKQPQYAILSALSNGPTFGYAGHDFNLNSNLQPGYSNIGHSYNLPNGITQGTNEAQSYLAGSYSSWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBY0</accession>
    <name>A0A9Q0LBY0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBY0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1164" mass="140205" checksum="A9EA9B95880F71D1" modified="2023-09-13" version="1">MSQNNLKPQLFIYYKQRKKDKNQITFKCNEKKMIQSNQNQNIWSFKDESNEKTVKEWSIEMKKPKSKTKTKSKSKHQKRSQSIKKTFPFEKTQSNLNFFIFTEDQNEKEKENEKEKEIIASEFLTAFITQIEEKIFGNQNQIEIQSSFTQIIKVHETIMEQFLKSKNNEKYLENLFSSIVYNLIKNQYQKFPLFRTFLIIFFQYSANLEMQNYFSEILFFPTTQITNIGDLVHFYEVIYHLIQIPSLNTFISKIKENLLLISKSLVKNYRFKLLWFIPIFEALQISESIFDIIKLKSEELNKKEVNKKFIKESIFMLKICFNSQIFKNTITPKMINTLFYSENLKYSLFEILFKKKESDQLFEIILDSINQNGLYEIIQNIICPTFLEWVKFWKNLENQTKEYFSKRIEKIKKDIMKNIGDFDQNKFYSIRENNFEIQPFNQKLSQEKINEIIELKKFENELDLDLELKNKIENLTINELLSIKPINMIDNKDIIIHIPLNHQLHYWEKHLSLNENFEIKSNIFKLIKTVNETQIQKIETTLKWFKNYENFNKKDDNNNSDNDSDNDNDNNDNDNNNNNDNNNNNDNIQKESENSQSFLIILKGWKTQILQKIQKLKDPDQCLIYDFYDYSNNRKLYSPFFLIFNENYSSEIQNTWTLIDNFHEKENILNSFDSHFLSYSKLKCPEIFKILDKIKKERSITNDEIQIQNQNQNSEHITTFLDIRSSKLFQYKRKRKEKEKDKKQKDIKLNELKNQIIPNVINKWKEFRNKIIQSTITFKELDYYFPIGNSDELNNSQIQQLSFYDFEEKNEEKEQKEQLSVNKIKQFLKCRKLITSRDSFIFLCKSKFKQNPKFYLDWKSVEKYNISQVEEVLKEALILGLKEETIEFFGDLFPKTVVHPMKKNKTKNKVNENFNSDIFDWLKDNNLRDFEFNQKVDPNQFNDQQLSQAAIYLRSVRERIKRYLYQQFSSLQNLINEISKSEDEFLKNSSKNPLNTRFLQKVFIELKEKIEKTQASPQQKAQRIITKIFTEKSKFVFRFAQNLNDENVECQIENSDPIPFEDLLQVYYTIQDSDNFVISPNYITFENDQELNLKAFYSKFLEIFPIIEECSSTLTKLRNFGHWDYFSDFNNQKDNKIFIKDVLISQNNDWEQEIQNLNIKFHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDD9</accession>
    <name>A0A9Q0LDD9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Abc transporter atp-binding protein/permease vmr1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_01798</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="PYAWPSQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="940"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1070"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="95"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="499"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="819"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1134"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5070817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1389" mass="158214" checksum="802E8E656BDB07EA" modified="2023-09-13" version="1">MKKEKISYIPNKEIKANIFSRLTFSWFGSLAKTGYKRPLIQNDLFELRPQDFCSKITGELEPNWNEEKKQTKPKLINSLKKQFKKPFLLGGVPKFFGDVCSILNPILLQQLIKYMSDSSASQSTGIILVIFLFLSGIIRSFSENLFLDQVIKVGFRARSGLISLIYRKSLLINRKISDQQQKKQEPKKEEQELEKKEEQELEKKEEELKKEKEEELKEKEKELKKEKEKKLTKKERKALAEKQNEEQIKSNLSSTGQIVNLMSSDVTKVQEITFAFHFLWSAPVQVIVCLGLLINLLGASSLVGFGILVLSFPINGVIFKKFTKKNILLMMQSDSRIKIINELLQGIRVIKFYAWEKIFKKKILDLRDKEISILKSILILRMFLMVIFTILPLLTALATFVVYGSTGNKLTAEKVFTSIALFELMRVQLLFLPWGMVALANFKVSMKRIETFLLSPEIPEENVEIHRQRVDENSNEVQITIQNGSFTYDTNNNHNNNNNNEIDIKKEIPLEEQKSQKQVLLKNISLDFEPRKLTMIIGPVGSGKSSLLAAILGEMVQLQGKTTIKGSIAYASQEAWIRNGSVKENILFGHALDKKRYNQVIESCALIPDLAVLPAGDSTEIGEKGVNISGGQKQRISLARAIYSNADVFLFDDPLSAVDAHVGRHIFDQAILGKVLQAKTRILVTHQLQYLPHSDFIVVIKDGEVFAKGTFEELIHKGVDFSNLLGDQEKRIKIKEKEKEKIKWIDLQPETESDIGDNFEVGTDIELPPNENTEKEISKQKNENKKAELVKEEEREFGAVASFYYKRYIKVAGGCCFLFIVIISAIFRESLRAAADYWLAIWTDGTIFHDKKDKFYIGIYVAISCGMFLFAFVFSGVWVFASIRASRTLHHDLLYSITRAPTRFFDTTPIGRILNRFSKDMLDIDLIVGGDFENFISTSIALLAVLLVIASVAPYFLIPLVVISYIYYKFMQYYRSTSREIQRLESISRSPVYNNFSETLTGLSTIRAFQKQKEFIEINDTRVDASTNAIYCNFGANRWFGIRVETISSIVVLFISIIIVMQKDSMNSSFAALALTYSLQVTILLTWIVRYGAMLEQHMNSVERCVEFSSVESEKPEIIPHHRPPKNWPNLGKIQFDKICMRYREGLPSVLKKVSATIQPQEKVGIVGRTGSGKSSLMLSLFRIVEIYRGKIEIDGIDISQIGLKDLRDKLAIIPQDVVMFTGTVRENLDPSSEYNDEKIWEILEHVHLYEKIDGLEQKLETKVTEGGDNFSAGEKQLICLARALLKHPKILVLDEATSSIDTETDSLIQKTIREQFKDCTVLTIAHRLHTIMDSDRIMCLENGKIKEFDKPSLLLRNPNGLLSQLVHRTGPKTEAHLKKIANGEESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDK0</accession>
    <name>A0A9Q0LDK0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 41 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDK0"/>
    <dbReference type="OMA" id="WHELAGN"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16484">
        <property type="entry name" value="RING-H2_Vps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057779">
        <property type="entry name" value="Znf_RING_Vps41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23555">
        <property type="entry name" value="zf-RING_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="644"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="869"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="918" mass="107100" checksum="224B4B3B7ABFD4E1" modified="2023-09-13" version="1">MSNENSNENTNDKNIIMDNETEIPKQFIIPNKIHDDFLDAFLEEDDEIEEENYEKPPLLKYERIGSFNIQKEENDQELSQTISCLKLTNNSYIIGTHQGKIYNLPFDKIVEFKSQFSYESTLIDICLDSTCRYIGACFRDGTVIVFDSLNDQATKFDFDDQITCLAIHPNFKPKGGSCVCGTKTGKIIYREKKFFSRSKILYSGNGEIISLTWKSNYIVWSNQEGIFVFDIETENPLGKVPPLSGSFPSLNNYRCNFKWISSDSFIVGWANVIIQIQITKQRTVKWKSLPPFNFIICGIGFHDNDYLVFTMEHLKSRLTDEKIGKILKTIQNFHEKKEKKQEEIEEEIKKEEIFEYLQNQFNLIPDVRIITQKGEEILKETISIKGYEVCSHIDFRMETQCMDWEIDRGCQTQSKLYVFTSPFQFVRATEADADDKVTWLVERLRYQDAFDVALENSGRLKRNNPTKLGENLLRHLLASKNKFKIQSAALQCPKVCGENPLMWEKWISQFFENQQFQEISPYIPIQNPRLKQEIYEMILNSFLENDNLDLFYQTINKWPKNIYNPRAIILIILDKQKKINSLDERLALPLADLYIEIKEYDKALKIHFYLKKLDVFEMIELYNIFDSVSHKISELIKLDATKTIQLLVLNTDKIAPSIVVPQLSNNKQLLYQYLLDLSDRNPKSIQDYHVNLMKLIFEFDPKNLLNFFKGSNYVPLEIAYEFCQKNSLYNESVYILKRMGQNLDALILMLDKLKNINKAIKFVMKENDNELMTRLINYCRSSNPNFFTPLLKSVVHSQFQITKLLQRIPQGVEIPKLGEALKFLLLEYQSKVKLKNLATEVIIRDCAGLMFSLNSRMRMGMVIQKDRICPICSGKIVQSDDVVLFFCGHTFHKSCLREKTSNQPFCTECAVKQKSDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEE5</accession>
    <name>A0A9Q0LEE5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEE5"/>
    <dbReference type="OrthoDB" id="7301133at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676:SF314">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="DYNEIN HEAVY CHAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="110" mass="12487" checksum="5112A99DD5A08EA3" modified="2023-09-13" version="1">MVKDQQEAEAKRKASLEIQTKLEEQNKEIAAQQKIAMDDLSKAEPAVLAAKKSVNSIKKSHLEELKSMSNPPELVKMTLQAVSQFLGSKETSWGEIRRLLKRKDDFLFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEH9</accession>
    <name>A0A9Q0LEH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-coa-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEH9"/>
    <dbReference type="OrthoDB" id="7676067at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="335" mass="39086" checksum="BB67FE93988EBF64" modified="2023-09-13" version="1">MIKKFPLSEKFKKNFWRKIEGTGDIPSRYNASAIIYNQELYIFGGWHPEFKPTNDLFKFSFKTLNWEKIETTGTPPSPRLGQESIVYNKQMIVCFGSNDSVLFSDTFAYDFENKNWSTLHTKGQKPRARLDPIIALWDHKMFIFGGESENSEKLNDVFYLDFNDDLKWIPVLNRKNAPPPMSDMAGAQVNHLLFIHGGMGSHISSDIYCFDMEKLKWKKKIKQKTLHLNDDHKMIYFNNSLFVYGGSQGRSNRYLKRFVVFDLESKEWNEIEYQKNDEKTKDEKIGGNYNFNEIEEYEEDSEFPILFEDSRITLPDSQSKPAIPGGKIGPCFSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFE0</accession>
    <name>A0A9Q0LFE0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866:SF1">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="276"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1388"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1561"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1099"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="555"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="599"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1099"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1690" mass="198255" checksum="007B9DE499203E15" modified="2023-09-13" version="1">MGQLLTRKEIETYLETDFNNLIHFHYLKSSHNYGNLIVCHTTLQNYIKITQKPEESLKNIDSKNNKESIFSFIIQIIPKKAKAKENQKENENENEKEIQPNFSNKKKKNKKKINLEQYIHKIKIIKRKTDPIQEYKNIFEDETILFKKIPEINSNGKYLSVQPNQISKSWVDKITRILNKHSGIFEVKDVIETNQAIYLFYSHSSYNLQNILQYNQVLIQSIIKKLFIVYQLFKSLSYLQSNNILHGFINPSNILITSSKDLWVKIVGFNLSPITSDEYYIHDHKSIFEKWNLHEISNFEYLLHLNNFAGRKMGDPNNHPIFPWLFDFSQDPRIWISYYSNNKESKESTTQNDDLKENVENSRKSFRNLSISKFRLNKGDEMLDYFFRAYGYHISEGLSEVSFFVYKARRTPIGILKKFVRSNYDPREFPISMERLYYWTPDESIPEFFTDPLIFQSTHKDMSNIELPSWCSSYNDLIMINMQALESQYVSDNLHNWIDIMFGYKLSGEAGLEAKNVAEFSFHHLATHGFIQLFSSPHPIRESYKINQENRNENQNENENENQNQNQNQNQNQNENENENENQNQNQNENENENRNENQNENQNENQNENQNENENQNENQNQNQNQNQNQNENENENQNQNENENENENENQNQNQNKNKNQNNLIELQRKEFNTFLQTNFSDSMVIYNNIFSQKEDKLNGNEKNIKYQDLFSIGCIIFELFTGKPFLKFSKIQQFQKEGEIQEQEFKAIPSKIKQLMANIFISNKRKDLTADEILQSNIFPEYFTKLYDFLSNFHSLETSIDKFNYTLSHSQEIFKMPKEAISMIFPLLIQFFDNPETQIKSSSLFLEIMKKSEGKQCKTELLLPLKKLFQVYGCKELSQNLLDIKFLKVVKSRFGMKCFMEQVIPFVEEFLRSQYHSISKIASESLISIFKSLSDVFCFRYIINPLLKNLYKQNCKFMIEFLVEFILSKTKTNEKKYISQIVVSEILNLLNQNKKLHLRSGEILLENSLELLHVLIFDLEKAFFVSQFKLMKFNPIFELFKKPILFTNRNTVKLWVTQLLAIAVKIEQEGTIYYIFDHIGDLLDIFKSIWENENQNENENQNQNKNQNKNQNQNSESDITGNSEDEQITQFNISFSTNLHKFDIQENLQEYKNQYTHEIAFMIVSHLNLFIDLEMIRTIPNFSFLYFFLDKNEFFHDFVRKDLGEQLEHPSAKNETKQENDPFAYFQKDYVDNLSSTKKKIIRKSSCNSALEIPTFQKENNQVTNGEQVKISDVDLINKTEIKDVQENQNGLLNQKKMEKKMDNSMDPKEEKKIKRKASRVINKIQHSIGQTTQKILDSNLFFKKILEEKTFFEDSNWLSKLLLGGYYSLNSKGINLQGKIVHSYKAHNSSVYDMDVNSKESHFVTGSRDGSAKVWRVSESSLACSYQGHKQSVSRVSFVSHKSWIASLGECLHIWDIETQKCISKFDTENANPPFKILTFVNLPIEQTIVGETNTSSIQIFDIRSKKFVSTWKLSNTCSGVNRSIDANESQNLIGVGLTTGNVDILDMRMGVILDSWKPHDSLISQLKFHDEFLISSANDKKIKVWDAKSSTDFFSSNYRDPQFVTEISTLDNSSCFSLAENHLFSIFGHNLLDSNLDLKRIQINDVLNSHSFNFEGYSNLKTLNFLEMHKLLLLGSDDGLVHICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG99</accession>
    <name>A0A9Q0LG99_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Major vault protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_09546</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG99"/>
    <dbReference type="OMA" id="VTYRAPH"/>
    <dbReference type="OrthoDB" id="6125719at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041134">
        <property type="entry name" value="Vault_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF3">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17794">
        <property type="entry name" value="Vault_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17795">
        <property type="entry name" value="Vault_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17796">
        <property type="entry name" value="Vault_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51224">
        <property type="entry name" value="MVP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Major vault protein repeat" evidence="11">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="219"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="223"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="11">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="279"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="328"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="378"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="12">
        <location>
            <begin position="458"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein shoulder" evidence="10">
        <location>
            <begin position="520"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="661"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5072166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="838" mass="95409" checksum="13579CB1B8F0BAF9" modified="2023-09-13" version="1">MSGVLRLKADLYIHVLDENTNTVRLVQGPQTYTRKQNETIVSEPKKMILVPPRHYCVIRNPVLRKDNKIILDEFQQAKLKWGDTEIRFESTEPFPLYPGEELSGKIQELINLPVAQALRLRANRDFKEIIKKKEVPRSAGDEWYFFGPNTYYPRIEVDVIETVKSTVIKPNTALKIKARRNFVDRKGIQRRAGEVWLVREEGDYLPDVDEIIAGSVRAFVLTDKKALHLRATKSFKDYLNIDRKAGEEWLVTLDMTETYIPDVYEEVVGQVSKITLTTLQYCVILDPFDENNKQRIGHKELRKGECSFFLKPGEKLEKGIQSIYVLAWEEALLLRCIQPFRDETEKKDRIPGETWLVKGPIRFIPPNEVDVIEKRKSIPLDENEGIYVRDLETGNIRSVIGKTHMLEANEELWKKPLPQAVEDILNSESGGKSNINVEFQESKLSVNRAKAIRDPTRVITYRVPHNSAVQIYNYQNKTSRVAFGPDLVMLDPDEQFTVLSLSGSVPKRPNVIRTISLSLGPDFMTDVLVVETSDHARLSLQLSYNWHFEVDPKNPNDAKKIFQIPDFIGAACKAIGANIRGVVARTKFDDFHKKSADIIRDAVFGRDDSEKPNPTYRFETNNLVITNIDIQSVEPVDKNTLASLQKSVQLAISITTQSQEADAKQDALRREAQAKARLERQEIDDQIKAEEKRKKLLELRAESAAVKSMGTAKAEAKAKAEAAMIEGRAKVKQAELKLQAAEIKTKTEIENMKSQFKLEFEQQKKMNQLKIAKTKKMADIEINKFKEIVSSIGKDTIKAISQAGPEVQRQLLSGLGIEEYFLDPEKSPLALLGLTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGI8</accession>
    <name>A0A9Q0LGI8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGI8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="117" mass="13865" checksum="16E1441123E82326" modified="2023-09-13" version="1">MNSKLIFNSRIFRLKSFVEETGKKYYRCMTPNCGATLIRFNNQYRLNRPHSEECEKQIQGNESLSKRFWEFINQMASELGKTSMEIYQLAVERINSEIGEDDHFEIPPAHHVKNFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGU3</accession>
    <name>A0A9Q0LGU3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGU3"/>
    <dbReference type="OMA" id="YENTTAM"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5070970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="420" mass="48372" checksum="8258A81CE055DDA3" modified="2023-09-13" version="1">MVWLTVLCFLASLGLLTWYFYVQWQNSSDISSEKKMDSNKRNALGFKTMFWIMIAVDVIAVILVIYLRKRIMLAIALIKEAVSAVRAMPTIFFFPFITFLMLLALYAYWIAVASFLMSSGKPKAKYDDGLAQYYLDYENTTAMNYLTIYHFFGLLWGTMVIIAITESTIAGAISSWYWTRDKHNLPPSPIKSAFKRMLRYHLGSLAYGALLLSIVRMIRYTIEVIQRKLMKANQNKCVNYCFYCMKYCFWCLEGWLKFITRNAYIMIAVYGESFCKSTKRAWNLIGRNILRMLAVSVVGSYLFFLGKVMVTSVVLVISLAILKSMDSIAFYIIPAIICAILAYGIASAFFSVFEMTVDTMLLCFCEDCERHDGSSPDREPYASEKLRKFMDKNISKDSKHEQNDKHGKPKDNDDDDDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH84</accession>
    <name>A0A9Q0LH84_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH84"/>
    <dbReference type="OMA" id="AHILMHI"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="340" mass="39847" checksum="F217D466243E950C" modified="2023-09-13" version="1">MIHNSESGPCIAGSILGMSGALIYIIAYIQFKKLRNYPRKLIFVLSIYDFLISLALFLPGYTSTGFCKFQVYMIAYFLTSPSYWCFVISIIFLLKFYGYKYFETQRFFNFAHILMHIISITLLITYVVKANPTSNGRTHWCWIKQIPLEILIYVIYWFLLLGCILFYSIIIWKVYKAKNQTDFERGFQFKMFLIPLFYVFTAIFSSVKRLREMINPDVSPSPFLDFTQGLFLPTEGFWDFVLFVLADKETRNTIARSWFRCCCKPKNDDTTNSDQNTFSDLDSFKSIDLNKHLTDNKNQNQNQNINQNINQNQDSNSSNTSDEVESHSDLELSEFHQDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHH3</accession>
    <name>A0A9Q0LHH3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHH3"/>
    <dbReference type="OMA" id="ICENQTG"/>
    <dbReference type="OrthoDB" id="21085at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF104">
        <property type="entry name" value="PROTEIN SPRINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="235"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="378" mass="44777" checksum="27DA57322503657D" modified="2023-09-13" version="1">MKIKIKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNINQNKNQNQNNRNRNQFQNENVKNENNLNNITNNSPPILFSFLSNQSYDKKTLTQNYGKISEAEFLLPCTMKLSKFRGLTFSDIHNENKIIQFIYSTKKEEIQEFIRNLKKKGIQIDNLQTNLIRTKIDKLKEDIYLKIQQNVNRERLNLQTDEERQRINYCIEEQLEKIIITPFYKTIISSITSRVKKEEEEIQKNLKNLSKQKIEHFGISKHLNNIDWTIPIKIINGISICKYPFELLNIIINTSFSIYETIERQIRNRPKILNQQLIAGDDFLSIFVFILTKTHSDSLKTFEDYLINYGDPLELSTESGYYLTTFCSALEFIKINPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIK0</accession>
    <name>A0A9Q0LIK0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIK0"/>
    <dbReference type="OMA" id="FEMADTT"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="221" mass="25416" checksum="F643656DBDE95CD9" modified="2023-09-13" version="1">MSRRNPERIPANQCPVCHKVVQTRAARWIDNNNRYHLACIKCTVCHKPLDREITKLHEGKIYCAQHAPTKAQPPPPVDPIDAMEKKVKASFDKLDTNKNGTLDPDEFSKFCEVMGDDFTDWEIHLITRIADQNHNGIITYREFRRFILANQTKLNEDDLKKIFNACDSDGNGTLIWSEFKKIGQYLGVELSKDQMKKLFKAADTDKSGGISFDEFKKIMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIL1</accession>
    <name>A0A9Q0LIL1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH endonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIL1"/>
    <dbReference type="OrthoDB" id="533617at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14382" checksum="E5FD754726B641A4" modified="2023-09-13" version="1">MSKIKLYSSDSFSDEKRKSKSDSEDSSEIESDSGEEIEGQCELCGTTTEKITIHHLIPKLIIKRMKRRKKKVVPIFAKICRKCHSTLHDTFDHKTLATRFSSIEEIRNCEELKSYLEWKSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIX7</accession>
    <name>A0A9Q0LIX7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho gtpase-activating protein 68f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIX7"/>
    <dbReference type="OMA" id="HACKLRP"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="13"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="333" mass="38039" checksum="B58C825187E96BA1" modified="2023-09-13" version="1">MSFWSCGAKKEGSPIVYNGKLDPILTSIINFLRENALEFPNIFRSTGRKKNVDSLLENLSQRQNVNLHDVGTDDVTVALKHYLRDLNPPLFPFRLYNDFISLSKKVELSDFDEDSIVNTMSSIPKENLVAIKCIFEFFKDVSDNSDKNFMDSKNLGIIFAPSLIKPKKETAKNLQSNHMAIQVIISFIIIHQSTIFSKLESKVGIIQMSSVDFQKIKPQKKRKRNLSKNTMNSIDSNLKEQRQITPNPDNLDNMETNNPHDDNVENLQSNSIQENENIQNSNENIKNQKQYSKISKKTSSINSNVPQPEIHNSDFFAEDLSDFSENAGRNDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIZ7</accession>
    <name>A0A9Q0LIZ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIZ7"/>
    <dbReference type="OMA" id="NCNANMD"/>
    <dbReference type="OrthoDB" id="5953547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="290"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="469" mass="55122" checksum="7BC8D1AF84EBF4ED" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFQNQNKKENEEESYFDFEIICEQNQTSFKTHKSILSSRSEYFKSLFDSKMKEYQENKLILKDISSPVLFSILNYFYSGKIEINLENAIEILFFSSKYLVGELIEISSNFVQKNLRIETIVDVLKLSEAMHFNQLLDFCYQFILKHFQKILTTPFFLELEENHLNSILSNDNISVNEFELFQSIVKWGKHKSDIYQEKEQLKNQISKVIDNIRFINFSGNDIENILKEDLIPNQISEKLIQFQKLQNQGNQQSLNEFIQKEKSLIFKSRIRFNSLIKDQEYLKKLREWINDDDFFFNMKLGFSAQIDGFDCRRWHDVVDNKGKTLVIIKTKDNFIFGGFTQVGWSSGKKRYIPDLSAFIFSLRNDKNNRNPEKFPVQKGLEEYAIAYDYSTKGPTFGAGTDFGLISDLRTGYSDFGYTYKLPIGIKEWGTNESKSYLGGSEKWIVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ25</accession>
    <name>A0A9Q0LJ25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bud site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ25"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="573" mass="67089" checksum="CD48B728F2538D8E" modified="2023-09-13" version="1">MDFIFTNEYLENDLGESLLTRQIQIKMKKHQPVVIYGFYHHVIGVDCSSISSIASYFARLVSSQKSSHFNNKQWDIISGTFCSFNAFSKLDLHVQFYLPGKFTFCLVDQDGVKIDLESRITSNLNLNQNQNQNQNINQNQNQNNQNNRNNQNQNNQNNQNNQNQNNQNQNNQNQNNQNNQNQNNNNQNQNNQNQNNNNNQNHNQKQNNNQNQNNQKQNINQNQNNNNQNQNNNQNQNQNNQNNQNNNNNQNQNNQNINQNQNNNQNQNNNQNNQNNQNNNNNQNHNNQNQNNQNQNNQNINQNQNINQNLNSIETKIWIETFISSYLRTIIVQNSNILRPLPIIKKVQDLDQKPIQNKILDTFKFLFWEGKKLGSSKSRRLVSNQQNFFTKSILKYFFINFNFKLAINFFSTFVDQDPEMSVPISKAYCKLRDYKSSNDILIKNYTRKPNSIPIISQLVKSLLRSNRIAQAIKLTNRLVSLAPFCPYSYILLAKARLKDKNFHGVFETINNIPFSSNKECQKFPLLNLDDLFPKPAKIFASDHKQNHLNIDSFNKKIPQKNQNIPKISIPKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ51</accession>
    <name>A0A9Q0LJ51_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ51"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="444"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="327"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="660" mass="77459" checksum="CECE632778F1F608" modified="2023-09-13" version="1">MKKFIRKKVSKKRGGMIEGLDAAWILEDKILQMSTPGGKVHGVWRNPENEVLKFLQKNKVYYILKVNKESRYDQQLFEKNGIQISTLDWEDHQAPTLEQAVMGVTLIWQIYQSNKCAIHCTAGLGRSGTIVAAFLMFLLDLDPETARTMVRKKRTNAVRRKPQIEFLLHWHSFLKINPFIVKQMRSACLIPPSNIQAVRSYFQFIYSYNKIFSSFFFDNPSIKFGDHITYKSLYSHSYFRINFFFRNEKLYQQQNNLHNSLGLLPILGLEDSDIYIAVHNKNKNKKSKSLSLNKTEIPTKPVQNTKVLSDKAFNSLDNSPSQNNGKMKDIIKDIKEKNNQIQNSNQNSNQNLNQNLNQNLNQNLNQNEKEFELIHDFHQINLEEIEDTINKNQNQNENQIKNRIKNELKNENQKQIEKNEKQIEKNEKQINSLLFLPVFRKTLKELSSTITYVPTFLTLLFREILIYGASETLFEYFGTRNLVKVAQLYFQGENIDVDKKYISNSFGYLLLEFFYLQEEPIIPRENQQEILENVQNEENAMKVFRKLPIENQCILARLFEFLAELNLFYPTFHNLKLPNLSVTFAPALFGLHGSFPPEKYDKPLEEKKPSLASELLNHSLPKNNEKHPYPSFYYPVETFPRAARFVFILIRKAKKDRFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJI6</accession>
    <name>A0A9Q0LJI6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJI6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="377" mass="43200" checksum="E98D308F3BA359E2" modified="2023-09-13" version="1">MKKFDENQTMIIDNGSSTIKTGFGGDDAPRAVFPTVVGRPKYYGGNILISHKDRYVGDESSCKRGILIKKYPIENGIITNWEDIECIWHHTFYNELRVLPEEHSLLMTEPPLNPKSNREKTTEIIFETFNIPNFYLSNSPSLSLFASERTTGIIIEMGYQVCNSVSIYGGNALNDSILRMNIGGKDLTDYLQEILNERGYYFTTTAEREIVRDIKEKLCYVSLNFDKEMELLNNSNSIEKNYELPDGSIITIGNERYRCTEPLFQPSLIGLSQIGIHEIIYNSIMKCDEELRKEMFENIVLSGGTSMFQGIKERIEKEIKQLSPKNMKIKVISPPERKYSVWIGGSILSSLSFFKNITISKEEYKEFGNSIIHKKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJQ3</accession>
    <name>A0A9Q0LJQ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJQ3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="188" mass="22278" checksum="FB5F8BD98B2C7ED3" modified="2023-09-13" version="1">MSKELLKISRSIKERIIPVFPVGNENISKIELKYNEQFNKRKGTLADPLIYITKLVNSAQTYDITTSLYFIYSKHFPLRENVLICNPKTTKSDIQNFFRIYRFYNTSNEISNFKLENINSNENQQDEYFPKFLFTVLFSDDLNKANSNVLIKTIHRKLTIQQNIHFFYCVPVIHLKSTICSRLFNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK50</accession>
    <name>A0A9Q0LK50_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK50"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="447"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="552" mass="64304" checksum="CA47B0C3EE57EECA" modified="2023-09-13" version="1">MNEIIFFGRNQNPIIRNEKIKITKPIQFKFENENENENEKQIKQISSGISVGGRNEAILTLEGNVFAKGDDINPENPKEFINISSLIEDKNDRIIEDIVSGYDSIYLLTLNQNAYGIGSNYSCQLGFDSNVLKKTEKPILMMKNVSKIFSGNFSDYVFLLNSNQELFGCGYNIYGQLGLGESINEITINKLTKIKNIPKGKIIDIQCGNFHSIMLIEDEDKNPKRKLYSTGYSSKNGLGKEFRDTCEFTEIKSSLFENDDNILDFSVGRSHTLILTSNSKLIGFGSNYYGQLGTEDTKDHLFPIQIELPKLRFNDDIFNYHLSCGEFKSFLYYLPLSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLTNKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK98</accession>
    <name>A0A9Q0LK98_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK98"/>
    <dbReference type="OMA" id="MQLRYHD"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="434" mass="49229" checksum="DF3B5D9E1F19197D" modified="2023-09-13" version="1">MEKQKEQQEKKKEIDNLEPKSFDIIIYGATGYTGTIISEHFAKKIPQSKYKWTISGRDEKKLNKVMEKLKKIEPKLSIKPIIADIKKEETVERMTNATKLIINCVGPFQMYGETVIKACIKTKTNYVDINGEPLFINKIISHYQKQIQEQGILVVLSCGFDSVPADIGVFLTKQSFGKGKVMKIEGIFNFTISMSNGTYGTLINSVAKSKTESKGKKSNTKTSSQIYLDKQVKPNPFKKYKERPSMHKHKDSKLWVLPFSSSDPTIVQRTNDVSDVAQGIPTFRYHHYLAFNSFFRFLWTIIKFFFILQIAKFGIGRKFLGLFKSKAGGPSESARKKSKFEATFVGYGQSSDNSQKVVVNQMKGPDPYTSTAILVTHTAECVLQDLEQLERKSGALTPGLLGNPLLERIQKDSNFNFSIGYSNQKEKEQKQKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKL0</accession>
    <name>A0A9Q0LKL0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKL0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040284160" description="Fibronectin type-III domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="488"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="928" mass="105787" checksum="3335063B3FC3763C" modified="2023-09-13" version="1">MKLILFFSFFFFLIINIFLIQSNQNQNQDQNQNQNQDQNQNQNQDQQNSISTIIQELETTRLLTETTRYYSTPDEAWIWNLLDQFSGSGYFGDSVSIYKDVLVIGAFGANQAYIYRYNGSIWNQEQILDEPSISYFGKSVSIYEDIIVIGARYASKAYIYRYNGSIWNQEQVLDEPSITFFGNSVSIYKDVIVIGTYSDARKAFIYRYNGTIWNEEQVLSEPSIPYFGDSVSIYKDVIVIGTYYARKAFIYRYNESIWNEEQVLDEPSASYFGWSVSIYKDVIVIGDYAAKKVFIYRYNESIWNEEQILNQSATYFGYSVSIYEDVIVIGARYANKAYIYRYNESIWNQEKFLSESATNFGNSVSIYGNFTVIGTYGSNKVFVYEGSFIPQVNILNCSSLFSLFDCYWDKIEFPSTLKYQINYGYDWIDIDSPILEDGNVYYQQFNSSIYDNITGNEYYSIQIKACDNVTMKCGESSSFINLTTKIDSVKDFQLSNPSNNSINVTWDYPNVQINEGIAHLNHYNLSYFIQSQPDLISFISVDNSSLDYFLNNLESENDYNISICGCRTQECEGDDKGEIVESSISLLFGEITNLTCSISNSIDINCNWNQPINCSIPFYYNLTYQSIYQNDSGNYQSTSSNQQFTVQFPNQEYQINISACNSNGKCGYISSISIKTDNLTSPIIYETISKIEEIEFNFTKLTNANNYSISLNNETNWGKFTSLDLSGNEIIGIISGISGNIEYNISIRGCSDLNCETPYLGLPSSIISTRAKLGNITSLICNSLINGFECNWNSLILSSGLKAYSFTYNSTSICLTNLTTNYSVSSGLNEGEYYEISIYSSADLNCSFNEYSGINSSTSITISSTNESNDNSKITSISLGIIIPIIVIISIIIIGIIFYKKKKRRKQIIKEIIKENEEEQELQDNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL14</accession>
    <name>A0A9Q0LL14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly [adp-ribose] polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL14"/>
    <dbReference type="OMA" id="RISTGHE"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="36"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="237" mass="27167" checksum="4173F28F6C8EED11" modified="2023-09-13" version="1">MDKQANQESNQNRKDHSDELKNRNEKDYERILKEKKVYTEVDEEINKLVEIYKGSIVEINNRRNSEKIDSIVNAANETLLGGGGIDQIIHAKAGPGLREECIKKFPEDSFGARCRTGYSVITGAHNLPFKAIIHTVGPYLDDSGNPQPKLLEFCYKHSLMYLDGKDISSIAFPCISTGYYGYPMVDACEIALGYTRKFLDDPDNRKNTKKILFCVYNDLEFKIYQNLFDKFFPKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL90</accession>
    <name>A0A9Q0LL90_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chloride conductance regulatory protein icln</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL90"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="245" mass="28536" checksum="4C069CDA39728A39" modified="2023-09-13" version="1">MGFHSIQKPKDNQKPNLEEEEEIKHIQSNTILFLSETENEGIGTLYVTTKNVIWFSNSTQKAYSVDFPSVILHAISRTENSIKNENDIENQNIDFNFTSLLCQVRIQSNNNEEKKIDEFSSDELENEFKIIKFIFPEQFMKDVYKVFCECSALNLDPLTDSSSDEMDTNENPQFFINYNDQIQQMFENGVFDNSMQEEKENENENENQNQNENQNQNQNQNLKSKSKSKSKSKSKSKSKSKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLM3</accession>
    <name>A0A9Q0LLM3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLM3"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10253" checksum="FEA913C7B905F046" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITKEIIDELETGIDYFQLNQTNPNLIDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLN3</accession>
    <name>A0A9Q0LLN3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst subunit Exo70 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLN3"/>
    <dbReference type="OMA" id="NIANFLM"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="42"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="256" mass="30271" checksum="0C65C0D5C3C0709D" modified="2023-09-13" version="1">MHPFENVTETLLSPENKDMEQIPDVLLLDFSNTEKQDLLPISRTQEEKSNIAFKFPNIANFLMKSLDTLCITLESKAKHQKDLVLSNLFLMNNYDYILSSIRTPQIFKHIYHNRILFAEKKIHLFQENYIQASWNKAISCLLLVNKSLFYDPIAKSKRKKSKISKAEKKEIRSNFSNFNLELESQFRCQKNYVIPDRTLRDNIRKKSANLVIPLYQQFLERNSKIDFAKDTSKYYKYPVETVQKMIYGFFSQTINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLW1</accession>
    <name>A0A9Q0LLW1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLW1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="218"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="281"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="503"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="618" mass="72193" checksum="798B8D063F21EDBE" modified="2023-09-13" version="1">MNEILFFGRNKNPKLIKNKSNRITKPTQFKFENENENENENENENENENENENENENEKQIKQISTGDFSTIFLFKNGKAIEYLRDSNQNPEKIQIKENIQKVTADVRNEAILTKEGNVFAKGRDINTKNPNEFINISSLIKDKNDRIIEDIVSGWSSIYLLTSNQNAYGIGGNFYGQLGFDSETLKNTEKPILMMKNVSKIFSGNSSCHVFLLNSNQELFGCGDNGSGQLGLGESRKQTKIQKLTQIQNIPKGKIIDIQSVSMHSIMLIENENENENPKRKLYSCGDYHYNGLGKNENTYEFTEIKSYLFENDDNILDFSVGNRHTLILTSKSKLIGFGNNRHGQLGIINGNYQLIPIQIELPKLRFNEDISNYHLSCGYRNSFLYYSPLPFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLKQNQNEKLQEIISKKSIKESNQIFEIIYSNNSKINPKLYSEIKEIINSNEKIEETIKRIYLNENENKNEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTYPNLFDLLIKKFNNQNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM80</accession>
    <name>A0A9Q0LM80_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger (C3hc4-type ring finger) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM80"/>
    <dbReference type="OrthoDB" id="2343366at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="177" mass="20279" checksum="9AFB34ECB0838910" modified="2023-09-13" version="1">MYDSDFQPEIYDWIKKKNNNRFGAVLECCINYLDLRIHENPEDLCTFITFDTSAEYIFESKKVNPNLIEEFGSNLDIGGGTYFYTGFELAFKLIKDENEKFKREKSVIVLLTDGGDCNSTKTKKLLEEQLQNFPEVLIHTVGFGEAGNSQDFLKEIAQMGKGDFHLAKDNIELGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LME7</accession>
    <name>A0A9Q0LME7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LME7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="259" mass="31045" checksum="3400509B8C7CDA27" modified="2023-09-13" version="1">MNQFNQFNQFNQLNQKQTDLLNISSEEEQLLSDTSLEENSQENLNFLINPLQLSEELFNLGLIESKESINFANFNKQILMIILNLLQKIKQLDVENSEFQKQKNQIFVLNQKILEKNSEIENLVNENFQLKKEMKEIQDLFLNQKNQNQKNQFKNQNQNKKVFGDQKENNPFKFLDNKESRLRYSDIYSEINLSKKQKDFFDKEKELIVDLNKKMKNRKSFIDENDLIDEDSEENENENENENENENQNENQNRKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMI0</accession>
    <name>A0A9Q0LMI0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMI0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="285" mass="32728" checksum="D6E1155B3C0656DB" modified="2023-09-13" version="1">MNEIIFFGLNEYPKLFKNEPEKITKPIQFKFENENENENENENENENENENENENENENENENENENENENENENENENENENEKQIKQISSGYSGTIFLFKNGKAIEYLNENYSNQNPSKIQIEENIQKVTVGYQNEAILTIEGNVFAKGKEINSENTKEFINISSLIEDTNDRTIEDIVSGRNSIYLLTSNQNAYGIGSNYYGQLGFDSGILTKTEKPILIMKNVSKIFTGNSSNNIFLLNLNQELFGCGNNEYGQLGLGESRKDGIIQKLTQNTKYSKRQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN42</accession>
    <name>A0A9Q0LN42_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN42"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="760" mass="87295" checksum="20868146B362BAC0" modified="2023-09-13" version="1">MTGILKLCLNIGSGMVKAGFAGDDAPRLTFPSIAGRPKYQGVMVGMGQRDSYIGDEAMSKRGVLWLNHPVQNGIIQNWDNYEKILHYIFYDAFRVALEEHPVFMTEFVGNPKKQSEKIAQVIFETFNAQSLYLNDFCQSALTAVDANKTALVVHIGTGVSIVEPFINGNPIVENVQRQNLAGYELNLYMRKLLYSENHDLPLLNDTSEFEIVRDIKEKVCYVALDYQKELEKSYQMDISKLFELPHGEILRVNESLFKCPELLFQPKLQDWNYRSIQHLIFDSISKFDIQEQKDLLQNVILSGGSTMFNGFAERLKAELDLITQSNVNVVSLEYRKYLGWVGSSKIADKFTDFYSIDEYNENGKIPSFQDDPQISEMRNEFYIELEKEIPSQSLMQYGNAVVIDQGSNSIKAGFAGENLPRIKLPNLIGKTIKNEYYIGNETISNQELSLEYITKNGRIKNWDFFEKIYTHLFYKELNIEPSDKPILITEPIFESKAQKEHLTQIFIETFDVPSIAFELQPILTLIGLNKKTGVVVDIGDELTQILPIYDGKFSTNYKLPFYQYGGKNITKYLMKIMKKSGYYFSSTIDFEIVKKIKENLGYISQDYEQELEISKQSNQCEKSFNFEADKEVILNSARFECAESFFQPLRFYIDQPSIQQSILTSIELFEPNIQNILLSNIILSGGTTMMNGFEDRLRKELIDLSGNQNVFISSQMNNDILPWIGGSIFSGFPEFSQISLKKEEYEEFGPSRIHKFSHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN94</accession>
    <name>A0A9Q0LN94_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Synaptic vesicle 2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_06799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN94"/>
    <dbReference type="OMA" id="LLWFIWM"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5075937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="69035" checksum="711201C007D8FEF4" modified="2023-09-13" version="1">MEEMKLPHKNNKEELEIEEEMKINKTDRMSLQEAINLLGFGKFQILMIFALGACWSSDAMITISLSLLAPVVKKKWNLHSYDQTLLVSLSFVGMAIGASIWGHLSDIYGRRLGYLITAIFCLIFGVLSSFTQKFWQLVLCQFMVGLGVSAAPISFGMFSELLPTKRRGFHLIIFEFFWSFGCLLEAGLGWILITKFNWRVFLLFSTIPMAFLLVLWKWVPESPRYYYIINNQQKLNDTIKMISRVNKISFPDNFQILNPNSIQNLETSSLLSYDSNQNNKDNSIIKEKETEILTSSSDKDINEEISNHQTNSEKESDLKLTLGKNENEETNDNSLDDDIDDTLNDDNDNLLKENENNPKKSKKLKKISKLNRKIGKPRQKKHQSLWESLKKMFCKKYRRTTILLWILWFINTFVYYGLVFITPSFMHKDTFGNSYESTFITTFAELPGLFIALLIIEKIGRKITQTAFFISAGISIALLMIGSNPILHIVFAMISRASMIAAFDTTYAYTPEIYPTEIRSTGLGFCSGLSRVAGIISPIFAFILLDYNHYIPLATFSILSIVAGIACYFLPFETSGVSMTDSNFESFEKENPNGDDEEDELFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNF7</accession>
    <name>A0A9Q0LNF7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_06900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNF7"/>
    <dbReference type="OMA" id="CQMSAIT"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5076038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="126" mass="13829" checksum="43B12DE59A2AC6FE" modified="2023-09-13" version="1">MALGIPLKLLHESEGFIITVELKIGDIYRGYLTEAEDNMNLQLQNVTMTAKNGQISTLEEVYIRGSLVKFIIVPDMLKNAPMFRVPTEGRGKGLGPIRGRGRGGGRGRGSVGRGSVFNQKTQRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNW7</accession>
    <name>A0A9Q0LNW7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNW7"/>
    <dbReference type="OMA" id="QGQYCKL"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040310322" evidence="2">
        <location>
            <begin position="26"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="253"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="683" mass="80136" checksum="A1ABA95FFF4BA507" modified="2023-09-13" version="1">MKFRIYSFLIFLIIIQIITNDQTKCEEDYQKILNMSDPQSFEILFFATGRNLPIDPGDYDMCNSLENTHQCVFQFIIEALGTEMQLEWGLCLPKSCNNEFAPFALDLYLNEFFPFGKRDPSTTVTNCADELTKKITAGTVITSIVSLLFILFVIVASFRFYFVQLHDKKILKNQLNIQSDFHHDQIDSQNLSENSSWIQSDNVDNDDNFSLSEKKVKKQSRFSKYLWKFLYCYTFQTNFRKLIQKSPIENTKFLNGIRVISMFWIIFGHSIFFELYPGFNNDLTLFSPKGPPKKWPFQILNGGELGVDTFFFLSGFLISFLSIPKVQSKKLNIGIFYFHRIWRLMPSLAFVILIYMNISPFFGNGPFFWQYTEVIKETCSKYWYSSLLFFNNFYPSDNSKECIPWVWYLANDVQFHVITPIFLYLFSWKKIFGLISVFSMICLGCGMNFWLTHKYNINFYLFDDSMPDYMKYIYVRPYTRILPYIVGVGCAMLLIWATERKRKANDFDEKMNLINTRVTQTKSKTKSLIFAHLLFVVFFAILLIVVFLPYNNYKDEGKKWNINANAAYIGLSKLFWGIGMAGIVVIFIKYSNVFSLIKKFLSWDLWTPLARLTYNAYLMHPIIMYLANLSSRILFNYNAVPIFYATTTNVILAYVFSFIIFLLVERPFMNFEKILCAKFIGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQL0</accession>
    <name>A0A9Q0LQL0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQL0"/>
    <dbReference type="OMA" id="VIELYHY"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="291" mass="35063" checksum="9A847E681E09313A" modified="2023-09-13" version="1">MSENPDVLADELLTLNVHLGYEIQEYDKQIKAIQDKISQNHQQITKLKKKEKTSKQKKLEEKKSQLHKKILQQEKKMKQKVNELGKAAFENDKLMENQKIMNKKIDDIQKLTKKNKKNREKKEKEINQKLEEEIQEMKIQNEKAKKEINSIENELKEKKEEKQKFLNELEKLNKKINLNQDEVFQDLAKIFSQINQLYKEFRVLLTQDYEVNQINKDIELLKMKKLFLAKEQTLEAKEIDTEIQKFNQQIQNIFQNSDDKNSLKEKMQKNQKKLRDLRTEFKKKILQFSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQL3</accession>
    <name>A0A9Q0LQL3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQL3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10239" checksum="EC781FFE7A45B222" modified="2023-09-13" version="1">MRSELYRGMFLSVTKDTSNKVTDYSGLSNKSFQIFEYWIYSNQIKDEIQITQEIINEIKIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQW4</accession>
    <name>A0A9Q0LQW4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQW4"/>
    <dbReference type="OMA" id="TFEMETF"/>
    <dbReference type="OrthoDB" id="416752at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17769">
        <property type="entry name" value="NP_TgUP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF14">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="310" mass="34618" checksum="C43CF66A303C61EE" modified="2023-09-13" version="1">MEEKKLDGQAVGDCKDVHLPMDDEGRLYHIGLKRGELANRIITVGDPLRARSMSELLDKILFEHHSNRGYSTYTGLRNNVPISIIATGMGLPLVDFMVREGRVIVDGPMHIVRFGTCGCLDGEIPVGHVIVASKGSALATRDYDAVEENLQSKEVKNKIPYILTKVIPSDPELNKAILSELKEKLGEEKVHEGVNITADSFYSSQGRLNPDFNDYNSDLIEEILRKYPDAVSFEMETYLYLHLARSSVSKPIFATAACIALAQRKQDVFLDTETKHKVEKLGGQALIDALSKLVIKDEMNTDECVWKKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRA3</accession>
    <name>A0A9Q0LRA3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRA3"/>
    <dbReference type="OMA" id="IDLFDCV"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.105:FF:000004">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="252"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="404" mass="45706" checksum="EE7399177BC737BA" modified="2023-09-13" version="1">MEEKQSSPLSFEIQAKFGKARASILQLPHFRNETPMFMPVATKGSMKGLTSKQLIDAKCQTILGNTYHLSINPGTEILDINQGIHSFMNYPRSMLTDSGGFQMVSLIKLSEVTEQGVKFLSIKDNSEIMLTPEKSIEIQNSIGADIMMQLDDVVDVSISGPRSEEAMFRSIRWLDRCIKAHKRPTEQCLFGIIQGGLNTELRTICCNEMVKRNLPGYAIGGLSGGESKDDFWKIINLCTDLLPENKPRYSMGIGFPTDLVVCCALGCDCFDCVYPTRTARFGNALVRKGGTIKLKSPKFANDFRPIEEDCDCFTCQNYTRAALHTLVTKETIGSHLLSLHNIRFQMRLMEDIRKSIKYQTFDLFVKNFMKEQFSEAKNEKTIYPQWIIDSLSSQSIYLNEKIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRC6</accession>
    <name>A0A9Q0LRC6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid--coa ligase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRC6"/>
    <dbReference type="OMA" id="ARNSPQW"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="98"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="671" mass="77013" checksum="22069D76C25B482D" modified="2023-09-13" version="1">MGNFSIFEKKKPPPNPNTVQSAYPRTLPNDRNENTYSIILKENKHYVYRSPLALDSHLNQWKTETQTLYENLEDTSRRFATNRLFGTRSYDVKTKKYGDYTWVNYKDFAELRTHFGSGLRELGLVKHSRVGIFSINRLEWVATEHASYAYSFVPVPLYSTFGKLFIEYIINHAEISVIVTEEKHLELLSEVAETCKSLEKIIVMENRNEPGVKERLGDQIYAKKLVEKGKKIYMFEEIVEKGKVKPYAHEPPQPDDLCSIIYTSGTTSYPKGVMYTHRSMVAAITGFANIGYHYNETDRYLSYLPLSHVFERNLENAMVGTGGCVGFFCGDLRLVVDDIQKVAPTVFCGVPRVFMRIYDRVLERIRGESILKQYIFKVAFEQKRKAIEKNENSFLWDLLVFNKTKKQFGGKIRLVINGAAPLPSVHQEFFKILFARHTIQGWGMTETGAAGLVQVFDDIKGLGHVGPPVCCSDFRLESVPELNYSTEDRPYPRGELLIRGRNVFSGYYKDPDKTAEAFDGKWFRTGDVAQVLENGEYIAPEQLENLYTRSTFVMQIMVWGLSTENFLVAVLVPEKQPLLDKFSSSFPSLDPDSPKLYDSICSAPETKKFLLAELEKLGRESSVNGFEILKNLVIEPEPFSVENDLLTSTFKIRRHEIEKKYKDQLLSLYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRN7</accession>
    <name>A0A9Q0LRN7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRN7"/>
    <dbReference type="OMA" id="PIICADK"/>
    <dbReference type="OrthoDB" id="449062at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="232" mass="26618" checksum="EFCB2CA8509A2A98" modified="2023-09-13" version="1">MNNFPNNKVIQNKGCWALLNIAVDKENKIEIRNLKGIEPIIKSMNNFPNNQDIQEKGCWALWNIALDNENKIEIRNLKGIEPIIKAMNNFPNNEDIQKQGCWALSNIALDKENKIEIRNLKGIEPIIKSINNFPNNQNIQYWGCGALLNIALDKENKIEIRNLKGIEPIIKSMNNFPNNQDIQEKGCGALLNIIKHDHACPIICADKEKFYQKFLNLCFLNNFEIRSGHPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS84</accession>
    <name>A0A9Q0LS84_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_05683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS84"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="696"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5077584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="953" mass="111105" checksum="493CA88F4E5B6AC2" modified="2023-09-13" version="1">MNSNTSLIEQLKQNGYENVPKEVLDEFLWLMKQHKEENEEEIEKRSLSSFSIYSEDFSTEINSETNSETNSETETYSILDSFSNQTINESLSDFPSFSSEENTNQDTNQISNEKKGKETKSLVRRFIKCCLMNKKVALDNFKKENPKTGDYINQYLGKTFPLFCSVFEKKNESVEWLIENHADINQITKIYGTPSISAACMIGDKTIFNLLYPKKHDKDGNSQIKGKYEKANIDIIDANSWCPFRLACFHGHIDIVKILLPKILKNHKKSLLNQINPKDEKNPKDEKNPKNPKNPKNPKNRKNRKNKKNQKNQKNSLIHNLNEDPTQEGKNQTTALSAGAFYAIQNNQEQILKTIFETYMEFANKNDQKSIFASDGNENINKFELYSQLKFPNEKNNTLLHFSCANGKKEITEYLIANGFPVNEKNIFGITPLYLATSENHKNIVDILLKKTNGKPLADLKKKDNGWSPVHVACYKGHYKILRKFLEHQEGLDLFFDKEKENKNKNKNKVEKPKAPNSITLLLQSKKPLSLRKFALLVKDQLYPRNKNENENQNQNQNENQNQNQNQNQNQNQNQNQNENQNQNQNLIKRGFLYQNLGRNRYNYQYQLQKQQYFQNLNQNQNQNQNQNQNQNQNQNQNQNQIENQIENQIENQNQNQNQNQIENQNQNQNQNQNQNQIENQNQIENQIEIEIQNQNQNEIELPEIWFHKIILWQNQQNVFIANFAGRQILVKDFSNSSTLTALESFQNEKNIIGIKHPNIVSLIGSYEIYRSEGNHMIHIFRNCKTTLLIYLEENELSIKEKGEIILKISEAISFLHQKGIVHRNLSMQNIWIGEDNQPKIANFDLSSNAKKFRNSSSSLQLMAPEVLNFQPYDFPADIYSFGLLAFQIITQQIIPENVMMSSLPKLNIYEIIDISKDIPFYQLIIGCIAENPLERFLISEAIDRIKSELENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSB5</accession>
    <name>A0A9Q0LSB5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSB5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="264" mass="31754" checksum="401CC07FB265F1D5" modified="2023-09-13" version="1">MNQMKLSIKIQKKKEKRKKKRICSLCNGIQEKNHREKYLPIQEMKANSTYHIYKNCVRNIQSLEKRKYAYAMCMENTDKKKLEEMIQEEFFKWNATKTRLSNQKRLMKKTLQISKFIEELIKEYFIAINIYLTARSLTFLTKISEKQQKKLIFDNFHSNIVTPIMEYTYMFFSFSLLSIIGIFDFSVSVFFPIKSWHLIDNVIVFIMFSLVSIDIYNIKPEFIVVCGVIESTKEKFNQNFLRKHKFYKDLNAQICNFLVTFFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSG3</accession>
    <name>A0A9Q0LSG3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSG3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="23316" checksum="EF92C9DF78CA05B0" modified="2023-09-13" version="1">MDLKDAISFDSPVLTIISLWNSYIHYIIKNLGIFVYLEKEHLNNILEKFGEGNIKDIPLGFIFLPLECGGLGLFQPNIYIYTFKQSSDYRVEKPTTLKQSTEDLGFGLSPFTQYGTTSLLQQQNQMFSNQYGGGFAAKKPAFGFGPRYTSSSMKSTSMKAVPKMMAKRKVFGRAKSKSKPIFAKIESESDEYEDEYDDNEKNIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSM5</accession>
    <name>A0A9Q0LSM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSM5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="460" mass="54524" checksum="19C8514B031953F0" modified="2023-09-13" version="1">MEYIENPETEKAKLQVIIEEYLQSYTKSKTFQLLIARIATNQKLPQELKKFLLKSLNNETTRFENCFQSPNVLVIDMLLHFKAKLINILKTYAFNQLLEREIEKQLGRQYFCKKIMELDLHVKFFMERTDNSFRINEIKNFAKFVVQKYNKLVEKLSDILLVTHSLQISTEIWLALILELGFSYTINSPDSNSIDFDEDLSSTNFASSSLYSLLSNIHQIVDELVDRFQKFFSEEHNLYLLKNTLFQIKKFSLENYHFSHLQSEQSKWNVSTILETKKARQFLSTPEYKLFREEELAKIYNEIINELSISKRKENSNLKTDWGIYHKKYHLSNCYQNYFKCNKKTADCFLNTVSAKNYLEGTDTQNPLEKIVRLSLLEIADGIAYSVPEIALIFRILRNSSKKVPYQDCYSFIFQLSQVFSYSDSNIFLVSPPNLDFFTKFDTQWFRQQFPNCFSDHFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTP8</accession>
    <name>A0A9Q0LTP8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-17-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000045">
        <property type="protein sequence ID" value="KAJ5078757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTP8"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="392" mass="44154" checksum="9A688F18A51C9919" modified="2023-09-13" version="1">MNCIVIDLGSYSVKAGFAGQTKPTIKFQSAIGKNDKNSLIIGPTPQETRNLNTLDFLISEGLSTGSINWDYAELLYEYIFEKKLRIHDTSSTSVLHTLITHTTKSDLETLTEYFMEKLDVRHFNIIDQNVSIIASLPQTSGVIVNFGQSFTQIIPYYSGVLLKFSKSILNIGGKDLTDYLTQLLTTQGFYLDSPQGFVIASELKENYSFVNLFPQINDWEKLSNQFKNEISTNPKLMKRYPNFKELKPITHEFGNGFSFDFKSERYSIMEPLFEPKLIGNFQEGLPNVISQSITKCEMDIRRSLYEGIILAGGTAATPLLAERLTQELSGLTNSKVKIVNEKNLSSADLIVWKGSSTLAALTGFEQIMISQQDYKENGAHLIFSEMIKEFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVC2</accession>
    <name>A0A9Q0LVC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVC2"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="330"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="663" mass="77293" checksum="7450A9AA2F798539" modified="2023-09-13" version="1">MSQIEKETLSQNTFFQNFEINVKNPDFKSLVSNPLVLLLIPRQEEINKITPSSILLESHILIQGQQDPTQFITSNGIKGTLFKDATNQKSHREFVYLFETTPKSIKTIRKYIEKQDFSSIFKNFVEGISFPNIIDTTRPSIVYKSSIEFSEIENPVRICVISNVLGLPSMIPEKIISTTRFIKAIWSTPTQSVQYESAGVRSTIDTENPSDPLHIPDQPENKQSLFEDFKVAINDFKTFLDFLMKSIPQVYREIDNFITSILSSSKPTTKQTGVEMVNLINQMIQRIEDLVPISGHSKSEYQSQIQIKLEKWIVEETYDRIYYQNSDIDHQKDHEFAEKMKRLFFVELEHFDTKSRLSRPDIFQETQKELRKITEVKPPNEKLNCITDACKILGKIFKSNEGADDFLPVFFYVVLKSNIPRLPSTIEFLQFFTDEQKLIMSEQGYYFTNIFSAKCYIENLKPENLTIDPISFALYFSSKPKFSSQKLNSGLTSNANSRLSQNITSNSIPDYEKDYLLKQKFKIEHDFIDYETYLSQNLLNPVIYKSELAKKEFQNFENPQFDLQNIPSFKVSLESAQKDLLDIMNPFNGKSHNPKFNDYFLPKIIEFTNSHINETDQKSSFDFENFTFDKISDLIEKYHEVHKENTEYKTHLAYLLKSQSYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVK6</accession>
    <name>A0A9Q0LVK6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Autophagy-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVK6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="236" mass="27859" checksum="87808B03B2297E46" modified="2023-09-13" version="1">MSNSNSTSKIHVVVRVPWKRPIRIEPITEKTIEQEKQEKIDQKLLQFFSTKSLNENIDWDELSEFTGIPVEECIQRSKNLFQKHLEFFDKSIQQQKSNLQENKTKNENIKNYDLNDFKRNNQLQNQLKNSNEIGIEKFSEIVQKYKFDWMAISDVLKKEYFVELNPIECRTKYFQQVNDLSQILSNSSTLKSLNQNQIVLNSKIENLKEMNLKNAFPDSSLTQSALEEAFLDLNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVM0</accession>
    <name>A0A9Q0LVM0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000050">
        <property type="protein sequence ID" value="KAJ5078675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVM0"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="343"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="460" mass="53709" checksum="2B0084BE3BFFA98B" modified="2023-09-13" version="1">MKSILTIEGNVFAKGDDINPKNPDEFINISSLIEDTNDRIIKDIVSGADSIYLLTSNQNVYGIGSNEYGQLGFDSETLNETKTNFNDEKCEIIDIQCGDQHSIMLIEDENQNENPKRKLYSCGDYEYNGLGKNENTYEFTEIKSSLFENDDNILDFSVGRLHTLILTSNSKLIGFGENLFGQLGTGNTKDQRIPIQIELSELRFNENISNYHISCGDDNSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQNEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINLNEKIEETMKRIYLNENENENENGKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIKITQEIIDEIQIGIDYFQLNQTNPNLLDLLIKKFNNQNQNQKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVP8</accession>
    <name>A0A9Q0LVP8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="6">
        <location>
            <begin position="1768"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="821"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1184"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1287"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="823"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1185"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1287"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2141" mass="249534" checksum="80A0AD86AA7E94C2" modified="2023-09-13" version="1">MECLIAIPFFRFTSNDPKVLQLFPNDQILVFDYYNEEWLKGVSLTRTVTGIFPFNYVELKKENINPSDFESKKPENFQDLITKSKTLLQIKKFNPNENRKIQDQSIVQRFNLSAKTKTKCPFYLSQIFRMHDKKGDWRTYLFMIDKNEIQYFDTTKKPNHNFLIGKIPISDIDGIFRVHEDIENMMSGFGKNKKQRIKRSTTYSEPTYSFNFIANNQLYSLRTDSFDVVNEWANTIQLMKLLGNLKLSNPTQTDCSLIKSLLVTLDYLYNNALNERKKQRKQDLEKIKKMKQNPQENKSSDYKSYKMKKIKKKLEAIMVWKHKLLEYLFAANTSHYIHIANNPAPKCMGMTIEDSQSNVHNELHFSKFEMVTIIRSSDTEHWLGECNGKRGYFSSKSIMLLYQGKDEGLETQENYNSPNKQNNGFKMIQKESLWNSVILQRLDGFQDMETLYVRIKQRNIKWSERICALTPCSIYIFDAKKTSAEIVIEIENIQSIHKLQTRKDQFVVFLIKLHLSELKISTSKSMIPSASTSWIGKLQFLWSVQKVRQKIRNIAPHKQVDNIEKIRIDVIERKKQRQTLLKGFEKMEKSLVRTQQYQQFDPQKKTSLLSDFYGDSDGKNQNQNQIQNQNQNQNQIQIQNQNQIQISDDFHDNDDFSENDNFNESDNFNENESKIGKLKKSKETKLQLAQQYQTLFHLHLKQVFCLNELSAFAQINKQILRLIARLRFPGLENGIWFAFSSQGYRIRIKMENEEKEEDLAPSQMTKIENSMVLQRLLEDRSGIVETFQIAEYEDVFLSNMGRSPSFLEVLASPIKKKKKKKIESKLKSETKRKSKPESLKKRTKSTDEKIQKPKAKNLWEQVPNMDDLMHFPVFAADFVFVFVNKKWSRFWLHLHSWIMTFSKSSYSETPYRVLDLRNLLSLKFDANKHERDNVLTMRIANQPDIALSAENPEYAQSLQAVLHFLAFLRTAFPSSPTTLMGIPSLNQTNTSFPLFRIYSLLDWLEKQISVNNQKRSRNKNLIKLFQDAGDGSVLTFERIQRVSKISINHLRHWRSVLLSKLFYLSPVEKTEGAFYACSKNKPQLHLQMNVNNQNQVAENYLDYTRWDWIRVLSPKDLQDDSIPSFKGELIRANTGAGNALKKDMYFFFVTNDPQNNFNSKHCISLPTNEHVKKHEEIFRNHFRSKTSVNGKNPNQDEISKNNNGKVDPLFFMDPENLGEFVDGYSQENQAQAAELALDGPPPFLLRASVRYDKLKNSEPHWKEAILILRGTEIRKLLDSPKSIKKLTAKNRSKSKISKIKSNSKNTRERSYSKPEPLTKPPTNEPEKLLFSCGPYLELYVSDQDIVLPEDDRLISLPQKYRAHTIKIHNGTQYLMLAFETEPEFVAWTNCFQLTNSFALLNSVVIEPGYLCEIENSDLAEQTQINEPVDSEKTVIVPQKNSKYFQKNTFMEDMKQRIAENRKNLLSSKVFQSRHQSVFKQQQMRKFLEDSKNLKSMENIRDWLDNEIHLHLYKTSQARNEILLSGNDNINRLNQLETKLIEENRRAEKLRLWHRKILSVILRLYIKNSPDLRPRAYTLKSSEELGDDLECIYGNNDEFLVKSSEEKSLDEISFENSNEQNENFSVENPFEKKSIQRRATQKFQSKTTTTSETQNLFQSKEWLELKQIQPDPENNGITYVVNIKNSLYLLDGSAAIPVRPAQILEINVPRTKFNLYFATLPDVIKTQLSDEMSIFHPAPEPNKKMQLMHLLLAFDLKLVSGINTLLNQPEPHIIESFLVVFEYKKMEMQLFDLIVDTEVKNTQFKNSLFRVNNFSCKILAKFAQRIGRDFLVKTLRPFLEEMIELFQNNTTLTLEFEVINPFGDDNQSQNEKNAKLAANEQRIELVQKYTSKIMNTILNSIQNCPLSFRELCFKLYHKSVERFPDAGLSVISGFFFLRFLCPAIVAPHIFGVLGLETKLGPRITNALLTISKLVQSIANECPFHPDSDMFFFNDFIQGYFSKTQKFMKSLIQRCFVVSAAQDFEEIGIKKTDDILVIGQVETKQESNSRNVEDISQSKFVLGSIGKSMSQTWLIPTYVLDLKSKRFDYVLERIPATNEEADLSLENIYHFITVPSTAKALIQFINDSNDEDFKEAGNKFFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWI1</accession>
    <name>A0A9Q0LWI1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lute isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWI1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="165"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="688" mass="83146" checksum="0CCDE948E241EC9F" modified="2023-09-13" version="1">MGQILSDQNPNQFQNPNQFQNPNQFQDPNQFQNPNQFQNPNQFQDQFQDPNQFQDPNQFQNPNQFQDQFQDPNQFQFQDQFQNPNQFQFQDQFQDPNQFQFQDQFQFQDQFQNENSNQLQNENEEKSQKIEISKFYQFPTQELNQFLISELLSNYKTMFQNEENCDFTIYAGKNNQKIPCHKSILNSRSRFFYENHHEKSETEELYLPQFGYDIVKPIISFLYDSKFQFEVNKFEKYFQLAKYFKLTSLRIKIEKDVSEQINKTNAISIYFKSISIESNFLSNLCEKFIQDNIHKIIEENQIESINNKELREIIQMIQLTPKENRIELIWKLSQEWKEKFQKSKKNLIDKDKYIDPIQIQEITEQIQDFHMIIDNIKTHRYISSDSKIGNNPILSLTDQLQFLNEKNKELQQENEELKSKLEKQTNILNKNDQEITKMEELIQQNENNKLNLPKQILQPKKQPIFFKLETKEKSISETFFNNILNQNQNQIQNQIKDDWGNNNQQLKKQDDWGNNQQLKKQDDWGNNQLKKQDDWGNNNQIQNQNQIQNQIKDDWGNNQLKKQDDWGNNNQQLKKQDDWGNNQLKKQDDWGNNNQPLNQIQNQIQNQIQNQIQNQIQNQIKDDWGNNNQQLKKQNDWGNNNQQLKKQNDWGNNNQQLKKQDDWGNNQLKIQDDWGNNNQQFKNKYKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWU3</accession>
    <name>A0A9Q0LWU3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000018">
        <property type="protein sequence ID" value="KAJ5079999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWU3"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="488"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="593" mass="69315" checksum="C1D4379A13CCC3B1" modified="2023-09-13" version="1">MNEIIFFGKNSSIFSNQQIRITKPIQFKFENENENENEDEDEKQIKQIATGYFSTTFLFENGKAIEYLNNSNQKPSKIQIEENIQKVTVGNSNEAILTIEGNVFAKGRDINSKNPNKFINISSLIEDTNDRIIKDIVSGNSSIYLLTSNQNVYGFGSNKFSQLGFDSETLEETEKPILMMKNVSKIFSGNSSNSVFLLNSNQELFGFGDNRFGQLGLGYSRKEEIKIQKLTKIQNIPKGKIIDIKCGWYHSIMLIENEDENPKRKLYSCGYWEFNALGKDDEYIYEFTEIKSSLFENDNILDFSVGHIHTLILTSNSKLIGFGDNMYGELGTGNTESQYIPIQIEFPKLRFNENISNYHIYCGYENSFLYYSPPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISSKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIEREEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIEITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXL7</accession>
    <name>A0A9Q0LXL7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXL7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="122" mass="14607" checksum="34C395275324F480" modified="2023-09-13" version="1">MATCVLCKKSLRKKYYQCEDGHKICMRSSCKDQIIRENEQRFCVKCKKLLNIIKEEQNQPEEQNQPEEQNKPKEQNKPKEQNKPKKKNKPKKPSQERSKSIEKITNEEMEMILTLHFLSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZ59</accession>
    <name>A0A9Q0LZ59_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sap DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZ59"/>
    <dbReference type="OMA" id="HEVDHEP"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="504" mass="60641" checksum="CC99B516F3950433" modified="2023-09-13" version="1">MSDIIIPNKLSQSSLEKELKKRKLSSKGSKKELISRLESALKKEKKEKSKKEKNKKVKSKSKSKSKRKNKKDSKNKKKNKEKSKRKKKNKESSENESENENENENENESENENENENEKIENQSENKNNNNDNNNNKDKMETEDKNDDQVGRKQKQKQKTIDIEKEKEKEKEKTYSEKIEVDYDDGDIETEKKETYSKTENEKMEIDNEITKNYLQEPKVNENTTIVPPTKTPKSRVLLIKNFVRPFTSYSARQLLSKTGKINDFWMNNIKTHCFVFYENIEDAERTRNAVYNLRWPPSGRKLLPDYFSEEEAEKIVKKYRTSPTTKGYDGLDINETGRSEKTPKQDISRSKRKVDEPMNENQDKSRLRTSRYSNSRSEKKDDEKYEEEKKERFREKTRHSEREKNHDFDYSRDKERDKERDKERDKWREKERDYHDRYHHSSRHSSRPEKIFDDKDERRIQFLKKQDQFLEKFFLKTKTKPHLYYLPVSQEQKTSNNLTPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R3Y7</accession>
    <name>A0A9Q0R3Y7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R3Y7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="149" mass="18130" checksum="F253B9F48681F7F0" modified="2023-09-13" version="1">MIYSNRIINSKLYSEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIKIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4T1</accession>
    <name>A0A9Q0R4T1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4T1"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="30"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="492"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="828"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="850" mass="98654" checksum="EE3BB2A4B2F6CB6B" modified="2023-09-13" version="1">MSDLTVEELLKYSEIEKLSKEDNQTDFTKLSLQEILLKWINSKLSLTQISNFSTDFQDSQKLLEIVKLTTNFDETEQISDQKTTLEIAEIILKFLKEKLKLKIEEITAEEINNGNETQILKVITNLFLNYHNHSSQDKNNQNLDYSNDDNDDDDKILDIEFVDSNFEDDMIFFNKDNFQNLAQFTNESIKTVFEITKIKHKLLALLPRIKEIAKILALETLNSFPKINEIVTENDLNLSQKLVFQSVVQIWNHYFQSEPPNASKIHLISEISRLSNQIEIDIVFQIKEKIENYFLEYNEALYREKETNIKFVLDSLFNQLLMNYHFSSCLSSLVSQLLIHNSCFESQNEELLSSLKVLLMTKLENIVIGSIDYDFVSNVMIELFYRIAFSSQINKIKTIIAESKKEAFGLTLRSVLDEKSSLGLKELVAKLIYERNELIHTKTETEIQTENMDYYNFGEKVRRSEEIMGKYFNLNHLEYFVALLDPNNCRDLIDTLSQTLFDFIEQFGVTIDFIRMVISQQILMTKGPEYLFRANDVSTKLISKYAVLYGKDYLIKTLSPTIKSICKSGLNFEIDSYVERDPMALKQNTENIRKYYYEISKAIFDSAHEAPKGFYILCEHIKTEICQRFSDSKDFLTPIGGFIFLRFFCPAILLPQSFGILDEEPSDSASRGLLLLSSILQNVASGKTFGTNREYMQPFNDDISANLKNREMFFTKLSNAEHIEKESFHVNKRAGFQNDLNVELLFDPNQILDLDPYTLANDFFTGIQSHFPDFCNDFCSTLGVSRLSSLTKFTNQIEKNDTQKMLYIIQFIENVFLDAKNKLKPDDTSQNQQNDSNTRKPSYQNLGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4W3</accession>
    <name>A0A9Q0R4W3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4W3"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="112" mass="13587" checksum="F04EC28564EC4683" modified="2023-09-13" version="1">MKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNEANPNLFDLLINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5C0</accession>
    <name>A0A9Q0R5C0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5C0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="196" mass="23639" checksum="3C9DF2422343346F" modified="2023-09-13" version="1">MSLSRFLDSTTTKYSTLLDRIHKLLQTDAFQKIVYDTLIEMIQSGVEEQINIYEWDLIKIIREKWKNEENYQSFNSFLFHHFREKTIQIFSIFLNNINRNQNLDLFISQNQNVARLWQTIIAKTHLPVFHILKADDFTNSRSPFSYHIYSIIEENKYEKPENKELLSVIQKEICRDENTYADLTQKIFQRFPTLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R677</accession>
    <name>A0A9Q0R677_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5067976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R677"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="128" mass="15269" checksum="1429E2860687D2AF" modified="2023-09-13" version="1">MIFQKRPRISNLLEDLSPQGGEARSSRLYEFDKLSFLPLGTEDSDIAEKRVSSESLISCGHYSHDHQILEIKYKFKSRPEFKFKSKFKFKFKSKFKLQINTKIQNFKFRYPNINPNSIPRNFKYNSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7B7</accession>
    <name>A0A9Q0R7B7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gtpase-activating protein and vps9 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_11511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAPVD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7B7"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="7">
        <location>
            <begin position="143"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="8">
        <location>
            <begin position="782"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5069849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="935" mass="109423" checksum="CFE8703B0A469240" modified="2023-09-13" version="1">MKNLNQWILGIQKDLKGQTIRLSTEENTLKESRKKKEELSQKYLDNLVETLNMTTLMENFKPETIMNQAEEINSWKIAKFGFLRSPLTFVQLHEYQKLYQFIRENPIIFSSAILNSELSNNEVHDLVSTGIPSIFSHFGSDFEESLFLIFLNNCLKIRAKQCDSKNFHQFLIGNQFIFQLLTVYCKNSNSRKYKISALREPIFEVIQSTNLQFSLAQITSDTPTKRLSRKILSLCKNFVTGLTNKLKILPQGIRWIAYKIKKICQKNNFEQYKLILRDFIFHIFLNPAIIFPGKNLYQISKLFWKGHSSVQIIAQDLDLDSYLESFGKPDPSFISKLKDIKLGNDIDDEKIKLSSSLCKLSDIYQNHRILFRFSKKIKKGKIKDCNQFLDNELVKYTLKLGKPQLHLTEQEGMKYLVFTRKEKERKSKRTSSISTTESNEPIEFSSEKKEVIQNYQDIEVHFDNQNLREKEDEDSNSISNLNLNQNLSENLSENSTQNLSENESKSKNLFDINLTDPSESEHDIFKDTEQTVFNPKPLQNNKDVNFFKHSNSLNVISNYNKIHVKDKNKEIINLTNEEEKLKLALVSMPDILPEDGVTLIEILKTKSQIAQLSGSTSLSCLLESTLLILSTLPETIQKEGFESLLKNLQMDSSIETKLKKVLQEKYKNMEMISIYEERMERILQKSQGYKEFLSSIVAEYYLKKQRKKFQAMKDIIQKSVSVKHLTELTQKFFESIDQLVSQDQICSLFQGVEKKITHFIENYLLCQIYDEFFYPKFEKQLIQKDAEFSVKIIKMRRLITPQFLHIPPEIWDESYWYLPILEFSKIIKFKPPLLKVKVLTKCAQYIKNILLFRGWDNAGTDIILPIIIYLIIIANPPQFPSNMKFIEMFIDPNLLDTTTEYWWTNFKSGYLYLVNLDLSDIHNLQSFSEKKISNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7L3</accession>
    <name>A0A9Q0R7L3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7L3"/>
    <dbReference type="OMA" id="TASIHPF"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="123"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="195"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="270"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="324" mass="37553" checksum="AC3DC90A9AFAB7A8" modified="2023-09-13" version="1">MQNNKENKEKQEKKEIINEPIDELDFIRRIIANFLRLHKCYDLIPQSGKVVVIDTNLRLKYAFQALAEQQYQSAPLWDSENNKYIGMLTVTDVVDIVCYFYEQKKIHEMNNCTISQWRKIKKMPGQLISIYPQTRMFDAIKQLSEKHFHRLPIIDPDSPSTILYVIKHIHVLRFVVDNLELIHPALNKTLGEFKIGRFDSIISVTSDQPLIEVLRLLSEKRISGVPVVSENNELVDVFSRSDITDFIVNESLDDLNISISEALAQKRKRLSSEFILYSCTLETTIREVILKIAEINVSRLVCIDKDNKVIGVISITDLLEFFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R886</accession>
    <name>A0A9Q0R886_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R886"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="294"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="394" mass="46165" checksum="08ED4B952D153B79" modified="2023-09-13" version="1">MSDFVPPIFLSIIKKPPNLQIIKDLCSNPQNLQIENLSPLHWAIFHQVDFEIIKIICESGFDLNNFKTSVFEYSLINYPSIQILKILIENGAYFPKNINLFVYCVENSQNFEVFQYICELGGNINIVGLNSVLHSICIFGCDISFAKTALKYGADPKMINGFEPIHYAKDQEMKDLLLNYHTLVDDLLSFLHQQQVNDLIIKTKDKEITANKTILKARITEEEMTKLLHFFKNINSQEVMHYLEIIYGGILPKKENFEFMHEFERIFPNFRKNLLFRKNVVLDIQRLFYDEESKDFEIIFGSTSIKAHKAILAARSALFQHMFISVNDNSNSVHDYTQKDPQIFQYFLKFLYFDDIDSDLPQKFIEDLEDCIDFYQLHPNCLLTEKLNEIKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8A1</accession>
    <name>A0A9Q0R8A1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8A1"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="12"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="24073" checksum="6BC7BED82EF90581" modified="2023-09-13" version="1">MAEFTKNFPQFSDSEIIQQNQHVKKLKEWINDNEFFSKMKKGYSAKKDGFDCKKWHSKCDKGKTLIIIKTKDNYIFGGFTQVGWTNDKSKWREKDREDDYGWIIDSKAFIFSLRNDKGDRIPEKLTIKQGQEDYAIYYWYSYNGPNFGGGIDGDISLNSKFQGWSNFGNSYNLPNGIEYESDEAKSYLAGSYNKWIIDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8U5</accession>
    <name>A0A9Q0R8U5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8U5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="21482" checksum="17AA9EFA99903857" modified="2023-09-13" version="1">MDVFNDQNLGSTYDTPFEVPSTVMITDQFGNPFPNKFVSIYTRFISATGYIENIFQQIQSTDSNYNNIFLKFQCDAFKSGPYSTAILKSPGEFYMENAPSNHSKIGYPFLFNNLIIVTLLSSEVPISGKMISAEIEQNAGNGKLDPITTLAVTDESGNAVFNLRMESGNTGYYTIKFSYNNDIHISTYPFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R939</accession>
    <name>A0A9Q0R939_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="VDEEHDK"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="44"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="39"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="43"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
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            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="63"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="99"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="169"/>
            <end position="201"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="202"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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        </location>
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            <begin position="1601"/>
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            <begin position="1608"/>
            <end position="1618"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000259" key="5">
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    </evidence>
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    </evidence>
    <sequence length="1766" mass="201468" checksum="639158F3AA3A2C35" modified="2023-09-13" version="1">MDIFKIIEQNDNESLKQIKTIPQKDLQKNGKPILHFAIEKKVSKEMIENLIQKGANPNSKNKENRNSLYFAIMNNSETKIIETLISKGAKFDSKNNNNKKKNILHFTLIHSQREDILQVIKLLIRKGADVNSKTNKDESALHFACQNHPIKIIQFFTKKKLSLNSRTKKNQTTLHFACQKNSLEVIQYLISKGLDIHAKTKKNSTAIHAACWKNSVDVIKFLISKGLDINAKTKQNASSLHFASAKNSLQVVQYLISKGLDIHAKTNFNESILHSACRNNSLEMIQYLISKGVDIHTKTSYNATILHFASQKNSLEVIEYLISKGVDIDTKTTFNESILHLACWKNSLEVIDYLISKGFDIHAKTNLNKTMLHFACWKNSLDVIDYLISKGVDINAKTNYNASILHFACQNNSLDVIDYLISKGLDINAKTNYNASILHFACQNNSLEVIEYLISKGLDIHAKTNYNASTLHFACRKNSLELIKYLIKKGVDIQAKTKKNSSSLHIACQKNTLEVVKYLIKKGVDINAKTRMNETVLHFACWKNSLEVIKYLISKGLDIHAKTIHNETTLHLACQKNSLEVIQFLVEKGVDINEKTINTKTILHYACQKNSLEVIEYLISKGIDIHAKTKTNETALHIACQKNSVEVIEYLISKGLDIHAKTIDNKTTLHYACQKNSLQVIKYLISKGMKINEKTERNLTVLHIACFKNSIEVIKYLISQGADIHAKTNQSQTVLHFASWKNSLDVIKFLVLKGVDLNEKTNQNLTVLHFACLNNSLEVIEYLISEGLDIHAKTIYNQNTLHYACQKNSLQIIKFLISKGVDIHGKTNQKETVLHLACWKNCSIEIIKFLVDQGVDINAKTNKNSTSLHFACSKNSLDVVEYLVSKGVNIHEKTNQNATALHFAFQPFCTLHVEKNSIDVIEYLISKGADINARTNQNATVLHFACLKNSLDVLKYLISKGIDISSKTNENATVLHYACSKNSVEVINFLIEKGVDIKAKTIRNETVLHLACRKNSLQVMKFLIEKGLDINAKTKYNQTVLHYACWKNSSLEVIKFLIEKGVDTNVKTKYSKSILHLACRSNSSIEIIKYLIEKGIDVNERTKENQNALHFACSKNSIEVINFLIEKGLDIYEKTNRGETVLHYACSNNNIEVISFLLDKGFDIHEKTNENATVLHYACRKNSLGVIKFLIEKGVDINAKTKKNQTVLHLACQNNSIDIINLLIEKGVDINARTSHNQTVLHYACRKNLSLEIIKFLISKGVDINARTNQNATVLHFACEKNTSLDVIKLLIEKGVDINAKTTRNATVLHFASQKNSIRVIKFLIENGVDIHSKTIYNQSVLHYACQFNSIEVINFLISKGVDVQLKTSEKATILHYACLKNSIDVIKYLISKGLNIKERTSRNETVLHFACRQNSLEVVKFLISQGFDIHEKNNHNQSVLHYACQQNRSIDVVNFLISSGLDINQKTNRGETPLSIAIQSRNQNAIKCLLMNDANVYQLNQTHLTKEFVDCFSQVYSLNDDFNNLLKSEENFGDLKIESNENFVFNTHRLVLLTRFDQDQVMLQKFINLCSHSFKEDIEVALNFLYTGFYDFKEFQEETTSETKPTKQQHHHHHHHHYQTENEVWKQKEEKIELFFQKMQIDSKTWIESKKGRKGVLKDLQKLYKEESTKDFTIICEEKEIKAHKLVLILRSELFKGMFLNVQDSSNKVHDYSGKSLATLEQLIYFFYHDEFDSNALNKEIIEELEDAKDYYQLNQKSIIDSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAP7</accession>
    <name>A0A9Q0RAP7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinitis pigmentosa 1-like 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
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            <taxon>Anaeramoeba</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
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        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="282"/>
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            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1356" mass="161530" checksum="FC13B9A97C88E945" modified="2023-09-13" version="1">MFKHRGKKPQKFKFNFILLSVYGFDPFSSIFIKFKRKNHNEQTKDIKIDSNGEANVNQQFSILVTLFKNLKTNDFDKKSLEIEIFLNEPKKSKKSQKIAKTIIYISEFNSKGENQQKDITIKNQQKNYKILLLGKLEKEKDDNKENNKEKENNKEKENNNKEKENDNKEKNDNKEKEKENNNKEKEKNDNLIHNQLVHSLSFDSAFDEDDSLFEDENLDGITEEDEQNSFQEDFADNTQPTDSNLILDYFKNDNQVISKKQEPSNSLNPKLQEPLNSSNQPKEIIRKNPEQEIKEIKAKLKLTQKKLSKTRKELEKKKKRIQDLSIKMEDSNHEKDMKIEFLLQTIESEKEKVEESENSLDIANKIIESAKNEVTKKEEQIQELKKQIQELKEEAEDLKQQIIENKKYKNLNQQIQNLNQQIENLEKKNLEQENQDKKQKQQIQELNQQIQDLNQQIEGLNKQIEDLNQQIQNLQKSNLDQKNYRDNQKEIQKLKKQIQDLKSKNIEKEKQKDPQEDKQLQEKKIQLSIELKKNEYLMKKIQRHTSKYNDKKQEMKENKENFEKELNEKNQAIKELKQEKLEEDQKFQEIKENYKNLQTQLALLNSQQESENTQEKIENLLKKKSQETNEIIQEKDQKIQALEKEKQNQINESNQTKEELNNIQQKLNKKKDKYKKSKQKIQELKTEINQLKQKSTELENSSQQQQQEQKINESNQTKEELNNIQQKLNKKKDKYKKSKQNIQELKTEIDQLKQKSAELENSSQEQELEMEEKRQEILLKEKVIEQKEKQMSANLEYMETTQKEVELQKKLVEIEVQESKNENLELKQKIEEKDEEIKLAKQSVNESKSKIKLLQSKLDMAEKALKEKSKNVKKNKAEKEQFEEDQDQKEDQEEDQKENQKENQKENQKENQNQIQNQIELIETLEKEMKNFKNIRKEYWIIQRLFFLSKPIYSNGIPVSASLMVQFLGNNNFFDENQSWEGIKIFIESIQTLIRKLKYKNTEKLCWLLSNAIYMRHILNDLIDEEFDSKSFSSEKSSDNSEKEKSNQSIEEEIQFISDQDDDMNENVINFKEESKTKLTKLITKLDQIFSSVYLILIQKITERLRPLIQKSYLKKRYMLQNSTRDLLVDNYYKPQVVVDYLNQVVVLFKKHCYPKELISSIISQVVYFIHSVIANTLFKDSSLCTYGFGIDLKYALTPLSDWFDSSEFPDLKVYFNSIKEIAHCLLMNKILMVDSTKSFSSCVTLCKSLNLFQIHKILTNFQPDEFDKEPILKGTMERFFQEAKNYYSKNKELSTKVDGFHIEKDEFFVFPVKNDFPNLKFEFWRNIEIPDLIPDKSQVELYVKGEELQESLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAR5</accession>
    <name>A0A9Q0RAR5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAR5"/>
    <dbReference type="OrthoDB" id="408439at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040275888" description="Fibronectin type-III domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="262"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="430"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="527"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="745" mass="82578" checksum="46319331D9F406DA" modified="2023-09-13" version="1">METKQIIKIIIITIILFIEIKSELTEETGGGFQGAGFVWQQTGVLNTTLNVSGFGRSLAMEEDVVIIGAPMTYVGVLPSAGMAFIFRSDGYNWTNEANLTASDPSLISFFGQSVAIYGNMSVVGAYLADNGSTISQGKAYVYKRNDSGWFEFKKLLAEDGEENDFFGGSVAINNEYIIVSAFGAAVNGSENQGKVYVYTYDETNVTHLVNFSSSDGKANDTFGYSLSLSNNILVVGSMADVNNNTNQGKVYVFEENSSVWNETCIINSIDGEAYDNFGSSVAILDEVIAIGAPNKTIGNQTQQGRVYVYRKNGSNWNSSEIFTAADGNEGDCFGFSVGVSVDSVIVGANRAEADGSSSKGKGYIYQNKTTYWIEEAILISTDGSGGEHFGSSVAIHENSSIIGADMSSYNNSYPMNGQAFVFKGSAKPPEPQSLNCTSMPYAWFTCNWTSVLNLTTYQIKYSNVWVDIPPNLYVNDSGIMEANFTHNNFTDILGNVNYTIYVRVCNDTNHFCSDPSLPSNITTMIGIVENFTLSSSNDSISVSWDFPNVSLFNNTPVISHYVLSYNNTSSSVNISLNSSTTSYDIYNLSCFTMYNISIWACRTLACEGEDQGEIQLGNISTSFNRVYSFWCNVYNYLTIECYWYAPLPQTVLPTFYNFTYNSTPHNDSANFHINNTETNYTQYNFTSQYQDEDYQFYISACDQFGYCGDEDYDYAYTGIIPQNSAFKFLIFNNIFFFLNFFLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB07</accession>
    <name>A0A9Q0RB07_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB07"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="194"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="470"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="575" mass="66891" checksum="55B030BB2DF33FF7" modified="2023-09-13" version="1">MNDCLFFGSNHQPFFFQDQPQTITQPIQFKFPYSLNGKQIKQVQSGYLTTFLFENGEAFEYGIYADYPEKIQIENIQKVVVGAQNAGILTKEGNLFGKGYQIFPQDPEELINISSLIEDTNDRVIQDVVSGYNSIYLLTSNHNVYGVGDNYYGQLSADSGILKKTEKPILMMKNVSKIFSGITSAHVFLLDSNQELFGCGYSEYGQLGLGESRKEKSIQKLTKIQNIPKGKIIDIQCAYRYSIMLIEDENRKRKLYSCGLHLFNGLGKEEDTYEFTEIKSSLFENDNILKFSVGNDQNLILTYKGKLIGFGRNGDGELGNGDTNNQLIPIQIELPKLKFNEEIYNYHLHCGSQKSFLYYYPPSFSNLEEDLIKLFRRKEFCNVSFKTENGEIIEAHKLILEYRLKKNQIKKLQKIISNKSIKESNQIFEMIYSNNSKVNPKLYSEIKEIINSNEKIEETMKRIYLNEKEKDFIIERKEKQYKFPKLILIMRSDLYRGMFLSVTNDTSNKVTDYSELSNESFEIFEYWIYSNQIKEGIQITQEMIDELERAIDYFQLNQTNPNLFDLLFKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBJ9</accession>
    <name>A0A9Q0RBJ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBJ9"/>
    <dbReference type="OrthoDB" id="449062at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="225"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="412"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="571" mass="66698" checksum="AD3F085C6E9B4FEA" modified="2023-09-13" version="1">MDKELKGIKQNFEELSIKFHQIMEEMIQKSQEIKQEIKKEKNENENESHQEIKQENENQNENEIQNENINQNQNQNQNQNEIQKENQNQNLNQNLNQNLNQNQNENQNQIQNQNENQNENENQNENENQNENENQNEIQNIKDHVDEFEILVHSLILLMKHFKNNEKIQELSSIALANLITEKPETKSKIIDFSGIPLVLLTMKVFSQNANIQKWISFILGNFAESRESKLIISQNEGFSLLFVALKNFMDNEEVIENCCFAIGNIVDIPENKKIFKDSGGVELILSIMQKFQKSEKIQQWCCLTLANLLAYIWDPEMKRKILLSCVVILNAMIEFEDNELIQRWGCLAFGNLADTRESQQKIGKMKVIRIILSSMQKFYGNEEIQINSCFAIGNLVAFIPQNKILVNKLEGIERIIEAMNKFPKNEILQRWGIFALGNLADNELNQKKIIELNGRELIVSIMKEFENNDSIQRRGFLALGNLLEYNLDISFIQEHNVINLLVSVLIKFPNNHEIFKWACFLINILSKSEEMKKLMNQMKIDKILSSGKNQFLQNKNLQKILIKTEEKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBX8</accession>
    <name>A0A9Q0RBX8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_08851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBX8"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5073169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="504" mass="59556" checksum="08538D625537F634" modified="2023-09-13" version="1">MIWKSLNAIIVAILIRIFIATYPYFDESNKSSFEFFDANKQWMKITTSKNISINEWYSKFQLPQNSKENIVKYCPPLKAYFSWINGKMAQNINPKIFEGKRNSNVKIFMRWTILIADFVFYFPTFALAVEEELNDQKKVIQWLSMCIQPVFLLIEHAHFKDDSVSLSLSLLSFIMLMENHHKLSSFIFALALGFDSRIWVFALPYFSIVIGNAFFVKTTNLNQKGKEIAKKEAIKYVFFVISIFILTLIILWIPFIRSFKDFLQIILNLFSFQKEPQVCIKGTPNLWFILNDHFKSSLIPLKKISFAITLLITIPINYNVIKKPSRRSFILSLFNTSFAFFLFAFPNHCQIDIVIPLLISTFLIQDQAIGFFMFWFIIVSAYSIFPLVLIENLVIPYYFSLIVFALLSAKIVVFNFHFPLSKFLFASSILFLFFNQVIYFLVFSHQLKTFLISLIQFVSFIHFVLFWIFFVFHQFKKEDFWFLMIKREEKNGKEKKDLIKKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC79</accession>
    <name>A0A9Q0RC79_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC79"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="266" mass="30666" checksum="9E68A8445D41C751" modified="2023-09-13" version="1">MIEEDIGYQAIVIDNAFYLGNSGILTLYSTGRTTGFVFGIGHEITFTEPIYEGYEIYNIIDQYQFGGNDLTNYLIKLLKEQDYSFDKSNDTEIARDIKEKLCYCSLNFQQELNQNETENQNQNETELEEAYELKNGDIISISNERIKCCECLFEPKIIGIDLEGIHKLIYNSIMKCDISSRKDFFNNIILTGGTTLFPNFKERLEKEIKQIIPDKMEIKIIADPDRKYSSWIGGSILASLSTFENVWITKEEYDESGPSITRGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD30</accession>
    <name>A0A9Q0RD30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cleavage and polyadenylation specificity factor (Cpsf) a subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD30"/>
    <dbReference type="OrthoDB" id="20774at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="1">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="157" mass="18613" checksum="F4DE61ECBB6889E3" modified="2023-09-13" version="1">MEKIHSKVLLSKTLIQNFSIQKTFLFNSNNEENSFDLIISKNNSIELINIDLNGKMKIICQQNIFGMINNIELISIKNESTNEKESFLVILSEEFDVSLIGFSYKYQKFFTLNSINLKSIFPKRRKHHFYSCLSFNRFKTKIYCCWKSRKPNFYCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDD7</accession>
    <name>A0A9Q0RDD7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol dehydrogenase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07063</name>
        <name evidence="5" type="ORF">M0811_13709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDD7"/>
    <dbReference type="OMA" id="NLMGAGC"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF102">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="3">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="204"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="409" mass="44765" checksum="87162040CD9DAFA6" modified="2023-09-13" version="1">MQVVNCLKGIENSITSFYYGKTQLEIGLGAINKYPEIVKKEKPKVMGLVTGKSSYKLNGAWDVVKKALDDEGIKLVHYDKITTNPLSSTIDECTKLFLDNKVDYVTAIGGGSPIDAAKLVTILMKYPGKIAYDVLHLTFETKEAVPLITINTTAGTGTEVNRFFVVTIDNKGPVLKPVVGSIAAYPTYSIDDPNLLMSSPPKMTIYTAVDSLNHVFEAATTKIRNPFSLILGKEVVEMVAHFLPIANKDPKNGEARYYLHYASALAGCAFDSALLHLTHSLEHPMAAKIWNLPHGQGLGILQPSVIKVVYPVLPKICALILGPIIPDLKGDPSEATMVAEKYEEWLAENGLPEKMGDVGFKEEDIDELVKNARETPVISNVLLPVSPVEATDELLKGIYLESMKPLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDQ9</accession>
    <name>A0A9Q0RDQ9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDQ9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="474"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="572"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="812" mass="90672" checksum="C5DD457649BFEB9E" modified="2023-09-13" version="1">MENLKITLVGVAQVEDNPYEGKVYIFQKNGIIWNQSQIIIANDNINISYFGASVSIQENIFVAGAPSTDILTNENQGKAYIFRNNGSFWNQESILIASDGNKNNYFGTSVGIDENFCIVGTRYAEVGNNSNQGKAYIFENFGSNWIQKQILIASDGKQDDLFGWSVSISQNFCLIGAFQANIGNNSKQGKTYIFENNGTFWIEKQILIASDGKANDQFGSSVSISISNSDKFLVVGASNADVGDNTTQGKAYVFENNGTFWIEKQILIASDGKSTDEFSSSISIDEYAIVSGASTANVGENQNEGKAYIFRNNGTFWNQEAILIASDGQAYDHFGKSVSISGNISLIGAYYSKVGQNIKQGKSYIFDGPPLPPQVNLLNCTPLFSSFECYWDEIHSLFEDIEYKINYNVPQPNWHIIYIPILYENVFYEIFNYSVYPNITGNVEYSIEIKGCNISTAACGNASNQINLTTRIDCVKNLTFETTTDSITLYWDYPNVPIINSTPKLDHYFLSYQNTTQTTNISISNSSTSFQITNLEIFANYSVSISPCRTQQCSGEDEGQILSSSIMTIFGNVLDLSCSLSNLSVVSCLWNPPNDSINPSYYSLTFQSTSANDTANYSTDSTSHTFTAKYLDHEYKINVSACNPNRQCGSISTFLIKTGVFGNVLNLSCSLSDFYFISCTWEKPNDPINPLFYNFTYQSQNDFGIRPVDTTQYSFKSRFSNEEYQIFVFACDEYFDCGNCSIFTIETGKESNSANSSTSKKITIICSIVIPLLIIFGVFSVFLYKKIKKMKRIERIEKEQTEVNKSLMFDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDT6</accession>
    <name>A0A9Q0RDT6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDT6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="396" mass="45619" checksum="6CBF0C8FB302E00B" modified="2023-09-13" version="1">MVDTILCRVCCGVGFCCFFLPAFIWLMVEVVTRSKFEKVDCEITDKYYVEYLVEGISDTYVPPSTTPQYRLPNPLDLSPKNVTPFHSFSPHSVSLENLFGANCIPRPTINYISFFEVDYTTKDGTKYNEYACNFGRRCFTRRGTGCKSSNCDVKITSQECKNFANLETDDMYEKYDPGDATCWYSKKYNEYATVHFPLPNFLWSLFFWIPLFFTCIPVFLWFRSKTKGSCDCFKSCDDVCCNCRCNCNSRRSVRNPPIPNNRPMEISGPTQITHNVSIPEPVGERDDMSDSSDTVEPPPPKLTGNEDFETMVQIYGNRNQTGNQTGNQTGNDYNYNYEPTGNDEIPMEVIQMQMNEYNSPYNQYYNQQEPQTNDQMNAGPLYNPYNQDSNQGNKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF60</accession>
    <name>A0A9Q0RF60_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF60"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="237" mass="27061" checksum="E40DBEF7E6E3F7F5" modified="2023-09-13" version="1">MNDCLFFGSNQFPKLFKNKPEKITKPIQFKFENENENENEKQIKQISSGLFSTIFLFENGKAIEYLNENDSNQNPQKIPIENIQKVSVGYDNEAILTKEGNVFAKGKNINSKNPKEFINISSLIEDTNDRIIQDVVSGNRSIYLLTSNHNAYGIGSNDYCQLGFDSETLKETEKPILMMKNVSIIFSGNNSYHVFILNLNQELFGCGDNQFVQLGLGKSRKEAKIYKLTQNPKYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF66</accession>
    <name>A0A9Q0RF66_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF66"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="335" mass="41237" checksum="90F1F84C8A77A011" modified="2023-09-13" version="1">MKPNYNSFQQKNDNKSFQKEKKITNFNENQIENQIENQLENQLENHLENQIENQIENQLENQLENGGINSNQVNQVNQMNSFFENSNDQIFPFLEDKTINLYSHSNQNQYPQNQYQNQYQYQFQNQDDNENKNENENQNQNQNQNENHQYFQNQYQNISNQYFPNQYQNISNQYFPNQYQNIQNENENENENENENENENENENEIENENFQNQYQNIPNQYFFPNQNQKIFQIKFKIKIKIKIKIKMKIKMKIKIKMKIKIKMKIKMKMKIKIKIKINIKINIKIFQINIFQINIFQINIKIFKMKMKMKMKMKIKMKMKMKMKINIKIFQMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFP7</accession>
    <name>A0A9Q0RFP7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFP7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="21774" checksum="B85C5EE3330A2CF7" modified="2023-09-13" version="1">MGFRSFIIFSGLIFVTLSGFIVGLLSLFTPEPWLVDRKLVASILKTTTDNEKINQILNDSGLADLLMVQYRFGSIFLISTSAFVLLITFTSYENQNVIRITQALLLILLASIYLILIDERKFSNNAKLCTFDFIYIFVGFIISLCCGIGKKPEDLNLKEDLNLKGNLKEKGNEKEKEDLNENLNENESKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFQ7</accession>
    <name>A0A9Q0RFQ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bonus isoform c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_00299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFQ7"/>
    <dbReference type="OrthoDB" id="295536at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF306">
        <property type="entry name" value="TRIPARTITE MOTIF CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5076979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="652" mass="70738" checksum="2DD19736388AF9A5" modified="2023-09-13" version="1">MKSNQLIELLYCSNCQKKFENDCYSLPTCSHSLCHKCLAKSLESKPEFQKTNETDEFITLLTCPVCSYKYQLEDEISEEIPMNKQINFLAKVEASPKKNEVMNCQECEKEKAVFFCENCHVFFCQNCCKTIHSFKAFENHQISPYKGDEHIVVHHALECSEHPNKVKEYYCKECQESVCIDCVIIGKHKNHMITKLESLSIGSDLRVSLALKRNQSLIQILDKKTNEIAALLDVVNGVIPVAKNKIDENFKKAFDLFQKRKESLLIQVDQISHYVTNQIRKIKTKYDKRIAELKLCEYYSNNLLENPTDSTILYEMEGMLNKLQDVEELTDESYVADDFAMAVDFDNLPTFFDSLGYVDAPLMNLKGGPGNIQITSNQEMSGEIKCSTFVVKSGAVLTVKPWDGKSGGVLKILARSKIIIEKGGKIDLSGKGYRGGPAVFQATNGKAKQGESYEGQGSDLQEANKGGGGAGLGTGQFGGYGGGGGGYGTPGDDAEPNRYSGQFHPGAKGGESYGDERITELYMGSGGGSGHPYSNGQTKGKGGNGGGALLLQSRRIVNDGEIISNGEDGEDGVPSTYGSGGGGGSGGSILFICNLLINNGTVSALGGKKGIAHPSYSQGINSSGGKGGDGRIAVKGRAKGNTTSPTWFIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFR0</accession>
    <name>A0A9Q0RFR0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_04232</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFR0"/>
    <dbReference type="OMA" id="VYVPMKE"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000107">
        <property type="entry name" value="inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="15">
        <location>
            <begin position="307"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5079211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="514" mass="57633" checksum="54AB92B60ECACAA4" modified="2023-09-13" version="1">MITDFVVESPNVKYGEDEILSKYKYHTTKVEKKDGKYIVHPVEEEYEFKTLTKVPKLGLMVVGWAGSNGTTLTAGIIANREGITWKSKNGTEHPNYYGSMTQCSVVRLGTNQEDGSDVNVPIKDILPMVDPNNIVLGGWDINGANLAEAMERAKVLPYELQKQLYPFMKDLVPMPSIYIPDFIAANQSTRADHVLKGTKKEMVEQLRKDIREFKEKTKCDKVIVLWTANTERYCDIIEGFNDTSENLMKSIDKNGEEISPSTLFSVASILEGCTYINGSPQNTFVPGVMELALEHQVMIAGDDFKTGQTKFKSVMADFLVSAGIKPVSIVSYNHLGNNDGKNLSAPKQFRSKEISKSNVIDDIVDSNRILYQEGEHPDHVVVIKYVPYVGDSKRALDEYTSQIFLGGHNTIVVHNTCEDSLLAAPIMVDLIVLAELVERIKFKKANMKEFENFHPVMSILSYLLKAPQVPQKTPVVNALFKQRACIENILKACVGIQPENNMLLEHKTHHIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFZ4</accession>
    <name>A0A9Q0RFZ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras and ef-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFZ4"/>
    <dbReference type="OMA" id="RIYMKIK"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001072">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="211" mass="23859" checksum="A312D6998D64E018" modified="2023-09-13" version="1">MEIKQDHEEQYDTIIKLVFVGDSAVGKTSIIQTFSDDLFDINSTPTIGVDFVQKIHELSNGQKIKYTIWDTAGQEKFRTITTSYYRGVQGIILVYDVERRHSFENLESWLKEIKNSTSGDVEIMLIGNKTDGKRQITEEEGLNFAKKNNLLFIETSAKLGEGISQAFEELALKIIQNPDIQKTETKNLVLTNEKDQETKENGGACGGWCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHV6</accession>
    <name>A0A9Q0RHV6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHV6"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="197"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68591" checksum="CC6E84BEF79078E5" modified="2023-09-13" version="1">MNDCLFFGLNEKPKLFKNEPNEITKPIQFKFENENEKQIKQISTSYSGAIFLFENGKAIEYLNENNSKQNPKEIQIENIQKVTVSYQNKAILTIEGNVFAKGRNINPNNSKEFINISSLIEDTNDRIIQDIGCSAQSIYLLTSNQNVYGIGSNRNCQLGFDSETLQKTEKPILMMKNVSKIFSGIISYHIFLLNSNQELFGCGWNNHGQLGLGKSTKEFQINKLTQIQNIPKGKIIDIQCGLFHSIMLIENENENPKRKLYSCGAYQSNGLDKNGNAYEFIEIKSSLFENDDIILDFSVGSYHTLILTSKPKLIGFGNNRYGQLGTENTDDKLIPIQIELPKLRFNENISNYHISCGYQKSFIYYSPFLSSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKETIDELETGIDYFQLNQTYPNLFDLLINKFNNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6A6</accession>
    <name>A0A9Q0L6A6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6A6"/>
    <dbReference type="OMA" id="DECQFEK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="499" mass="58862" checksum="8817ED32C903CC7E" modified="2023-09-13" version="1">MNQINETFISIKNLQQNYSDIHKKHQKAIQKKNETENLLKNLSKQGKQFQSEIIQTKIYKLDCLQTERKLNATKENSEILIKELEKKFSEIQQKQNQFENLRKKNQQDLISSLDSFSYKMNSNFKEKYLQKQNFEQEKIQNNINEHLLNIERINNEIVNLDENFKINKNQLKILQEKNQKYEESLENIENQIDKNSKILKKLEEDYIFNLNNLQQIESGKEEESQKLIGMIKKIEEENQILTEKILSKNSNRKRGLVELSFSNVDQNLDNNIINNNQGLKVNMFENQKNFISNNFKNLSNLQINLAEQAIISKGNLFLSRNPNNLNQNNLNQNNLNQNNLNIQNNLNQNNLNQNSPNQNSPNIKYNSIQNNSIQNNLNQNNLNQNNLNPSNLNQKNLNIKYNSNKNNQFIKYNLNQNNLNQNNLNQNNLNIQYNLNQNNLNQNSPNQNSPNIKYNSNQNNLNQNNLNQNNSIQNNLIQNNQFIKYNPNDFKSSKFFLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6B6</accession>
    <name>A0A9Q0L6B6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6B6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="546" mass="64226" checksum="E41D2CCB1B3FA912" modified="2023-09-13" version="1">MSNQLPNERHKKKHNHQHKHKHNHKHKNKEKNIMQKSSQDEWKDIDFESIESPKKKLEKNHWKKSKENKESKNNRKKDEQKDKKTNIINEPKKKESQKTEDYEEFKESDFQTQDNFLVEKNPVKKLISLENDEMKNSKKPEQKENIPSPPKKSSNLRIEVDNFNSDFSEHEQVSGEEDELLSHEERKSDDDSSSWGFGSTKSDEKNEDDEMLSDDSGGSIVVMTESDSEQDKAGDHIVSLFKNARNSSMFEAPINIDGEQPEFQPRLRRSNILGEDPSERPLIKKILEYRQSISEKQLPLSNLEEIDEKILIHRENDEIRLQIQKQRSRIDHLSIDCVETEDKINNLIKDVQEKFPFITKHQKEINISRLETLNEINAKLEKEKENSFKILKDLKNDLNSLIIGYHKLQKKITSTTKRNFKSVRIVSQETPYRNQEFQNPTIQKKQIIENQNKTNENIEKISSNLKSTIELTQEIEDLDCRLKDLQTTVLCCNQQQFFENSSLQSEGSILDTKLITQKMLISHLRGRLKQLGFDKKETEEKQNKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6E3</accession>
    <name>A0A9Q0L6E3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6E3"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="444"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="612"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="644" mass="75420" checksum="735D90EDCFA911E9" modified="2023-09-13" version="1">MLDLESEKKWKSIQLTNIKTPTPRFRPAHVLYENKVWIHGGNSVKDELCDELYVYDIELGTWQEVDQCGQVIGRRAAHTAVVYDEFMWVFGGETERYYSNNVFKFRFKTGEWEEIKTTGDSPRPQTYHTACVHKDQMYIFGPTYSEALLFALNFLTLSWNKIQIDLNFRGIGSSTAVVYGNSMFVYGGLDGGTVNTFNRFDFETNKFEKVVGNENGIIPGKRESHSANNKYDQMVVFGGTERGVRTYGNIYIYNYIDNYWEEIFPREGVTPSPRDDHSAVIADSKLFVFFGVTSNTTGKSEFSLNSQAFEDAFIYQFEYNLYSDMENFFKRQEFCDMQIDTMDSKFIEFHRDIVSARFLPNKFNEKNFILILKLEDYDTIISLMEYLYFNKFECIYQDKNEKLQKLAEKLELNELVNLCNGSLNFGKTKLGTVFEKLYQQNETKDFTILCQEHEIKAHKTILIARSELFRGMLFSSNDQSNQVQDMSGSEPFALEQFIHFLYTDEIKDDLQLDVYFSLFGISDYFGLSNNLLESKIEKILLKKIDKQNIQALLNHSVKENLLELKESCFFFIFNNNLKNNSVIKNFFSNEPLIQKEFTNYVKEYKLWFNQKKKKKEERETTPPLNLLNPTDPPKKKKPKNCQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L723</accession>
    <name>A0A9Q0L723_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L723"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="712"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="544"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1029" mass="126091" checksum="561478A90DB242E1" modified="2023-09-13" version="1">MKKFQYIKNIIEENDIFNNPKQIIIIILVHIFSNETNFRICFEEKWENYYLEDLNPIFSFPSKFKFSLSSIFDQIIKLKINQDENVETVETDETDENDENDETDEIDENDETDENDETDENDETDETDENDEIDENDENNENNENNEKEKQKKKEKKEIFETLFEISFNRSNKIKIDEYDEKIKKLIYKKFQESFDSNKIVNQEWKRIIELILNNRIRSYFESLNSVIYRNWIDFSIKIIIQIIEEIDKFGNLNLYKKEKYSKEIWEKCFDKFQIFEVDYKQIEKNQKIEKIEFPFSYYFFYFPEKINSIFEEIGKKKIFYSPEYLNDFLIYYLPPEDIKIYQEIKEIKEIKEIQKGLTHKILSTFNLEKESFIEIEKNKKSKFKIFFESNSKRYSIYQKQIKQNFNRKKKEKEKKEIIEIWEKLEQIEIERILLLFNIDFINNNIFKEFKFETPKFLIQIIEKCYDTNNTLLIENYKFLIRIIIEANNFRLKKQKKEYYSKQKNNQNYISFWKNFIKELIKEILKSKLEKLVKDIIRVFVFELEKIEISINLLLSKNIKLNNELSHSNILAEKYLEYKINQIQNEIQNQKRKGYIIKTEINQEIKKEINKNNQEIEKKIQREIQREIQREIQREIQKEKQKEDISTKLPKNWIWNSIPKIGINSLILLFERLKNENQIQNENQIQIQNQNQIQIQNQIQIQNQNEIENEKIKKEFPITCESESESESENESENENENENQIQNQNQIQIQNEDEKKKERYLSETKLDEFCKQLELEEYYCDDFCYVWNQYYLHKSNEKIILISPQTKLKEINENKFEQYKLSYKLRKDIIQELEHFRILPNSIYYIVNLIEFLLKKEFKKEEEINKWKNLKIKTIITTKKIGKQIENQIPKFIHSILFGIIKHYINECPKFANIEMNKLIDLYESLLEYYFDPCEKVHSKFKKHLSHQQKKEVIKFFEEEESNIQKNILENILKRIENLKIENNAETKKIFSSKDYALFQRLPESFKELKLKYIIHFYQICHKFYQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L746</accession>
    <name>A0A9Q0L746_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4704" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1687" mass="197669" checksum="B21CFF159F11500C" modified="2023-09-13" version="1">MSHASKKKQFEHNYFLQFGSKGNKLNQLWNQISNQNQKSTDLFFEFSILFIDTFSDWYVGVVTEENEIIRPTDIDKAILNTKAHPRNVIYTTLEYLSYEQNRIQILYKNSMKNIQRETFHSRTKKSKTVQNAEKSNFGNQEEIGKLLHSVIEIIQVISILCRSKYNRVVMLENKFIDLLLEFCKLICSLISERKNIFRENDIYAHLLVSNTLSIFESFHNLNDFTHSQTQNFFNLSFDLMLNILNDQNFEKNYQLKNQIFKIMINLLGKEKALKQDPNSSFKAKIILDFLFSITKPLQDEEFQLEMTESRIKEQTELIISSFRMIEKMLITYKSLGFEIIKQNMLANMSDFLCNLGAYSNDVFRVLFSEIDKFFHDLAANYSSVKSLNFFQYYFIETITQTFEKMVQMGNQFEENEVIIINFLSDVINAKHLDLFNLKWDMLFSHEKLYPVSMKFYEQVLRKFQRSEDYQFILNLLEQRKNDYDFTVICMETLITLVTIEPNSSIQNIVENNGISRIFSLIKFINTTEAEINQEQEKMKTKTNSNENQNENTNENTNENQNENLNENNENFEMGKKIEKDELDEEDWIALSFGNKNNINNINNSKNINNENIKEINNEQKYIRMQVQAATLKSLTSNILTMLLESPFAKRRLVTNPQIITIIISLMDGKSENENSFKVAHSHLLKLSEWVDPEKMKGQLKRFFKQLNKEIIQVAKHFKEQEKLRISILSKLLEIYQNCLQNNLKIQNVFVSVNGFNMLFDLFTLEEKVGEQIMQCFVYLFRNSKIFTHFKKDIGFKQFVELFSQENEKKEILWQNLLDILVLTGHFSIGKNSLIVCKKKMIIYLFKISRKMGLTINYVQIFLTLCSQSLHNLSICSEANLAHFLLKYLNTNGESMVKEPRLLEEFFQLVASLVFHSISVQTLRMFLHVLKSKLENEEISNKLFSILIKMVYQERNSPRFFFDFVGIAEKSVRLPFAGKHIPENGYSFACWIRVEIPHQNEFPMKKYKPRIFSVWNRGFDTGMQLYLEVNDQESSHHSSRKQSVDLISLDGTEEKETEIEHNMFNQISLRTVSKKTNENIASVKTELWVGVWYFVAVTHSRRKHRVSFYIDGTLVKKCDLKYPNFDRRTVFEKSAFGYDMQQKLLLGKIQEKNILSFYGQTSTACFYNKELSKEEIRKLFLDGYDNQEFTTRSPQQNKENTSFEEQILLYINVSSVRHKCECNNPFVFKKYGFAKHVSHPYFGNSFLLSESTAMLGGVKIYLPLLMWVRMNAERDGVDEQNSAKFNQTLHMILHLLKKSELLQLQFVRVHGMSILSHIIMNSELPLLSISSVQQIHQLLLEKQISHFRLHLVRDLVLNFDIWMKRGYTISNEIFSILSSAILSRGIEFDSHRMKSHMLDKNPESSHTEETESNDLTEPDGAVVPPESGGISSGEHEWRCIHKHHFRISVVNLAVILLLYLRDSMGNFLLKTRRDQTLFLPKEINNLREHAIKLLRSSLSQSKGDIETHENLLFLLHTCIVASDIPVVEQILSVILMFFQSKYRVVDPVEISNAAVFLLQKYSHAPSVLELVIKILNQMKSRLAKEDNEERTINNFFPFIHRILINTTPTQDTQYELLELMKDTSEGWNTVLFHTVLAIGNRTMDLNFVSILRTIKQDLIKSKKKRKILLNLFRMAAPAFPVLYSQQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8C6</accession>
    <name>A0A9Q0L8C6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000123">
        <property type="protein sequence ID" value="KAJ5067968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8C6"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="170"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="631"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5067968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="668" mass="77970" checksum="C177EE7B031DD963" modified="2023-09-13" version="1">MQNHTFSTSIPPKQTIQLTTSSLKRQPSRNKFTNELFSQLFPQLQAKFNLREQDQHFLPSNIKIDLIRRFLFQSKSNLQTKDSFTTSQSLPNLFLNAELACIEAPMKKTKSLKPLETEIEKQFKDIPFFQNSSFQSAIEPKMQQSTTNLMQSNYENPLHYLKLNWYSSNFREICKIGEGPNGAIYSSKNVIDGKEYAIKKIPLVSQNLKEALEKVKKIATLSHPSIVRYYSTWLDFWEETVSFSRSSSINDLTQSESDSEILSNESDLFSSKSFNKSHQNSFNFPNDDHSTPKIRKNSRFSQENTDENDGNTQNSINNGLFTDDSNDVFYRQKIPKFSQNLLENLEDVEFIEDENKEVIFNQTENDKNKFKKKKIQKSKSRTKSNSRTKSKENHNFQETIFCNEDVEQNQKDQELTENVGIMIERFSEAFISRQHKVISEKKCDFVLFIQMEFCDFNNLASWNRINQVNGINFIAVKNVFQQILQGIEYCHQRKIAHFRLKPENIFVNPSRSNKVKISDFGISTGISYGEENWGMKNKYISPEQLENSQNCSQKSDVYSLGIILFELLYPFTSQEENKKLILKLRKTHKLPSNFIQKYPDISNLILEMTSSNPNSRPEISDILSKNLFGNIDKIHQMKKKLSRKEKKLQNLQKQILMLQNRLQQDTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9H7</accession>
    <name>A0A9Q0L9H7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9H7"/>
    <dbReference type="OrthoDB" id="10616420at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4185" evidence="2">
        <location>
            <begin position="383"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="616" mass="71056" checksum="63CBBF2E5B7D8B79" modified="2023-09-13" version="1">MRKGFFIQTIIAILIHLAPIIYGISNKYTQSITIKLVFESFSGWGYLMNIFCLLMIFLNEAIFTTKKKYKEKIDLSLFLDHLILTARNIEVSICIGYWAVIIPLTVKFVDSPFSIINKYIDKTWFMILNDFILHALPLTIIFLPFKKSYLNMKKWITLIPFLFSFFLSYIIFSIAYFLISRNLPYLIEYSLGVGWALLVLLLYFLGSILAHSIGYLIFKKRKKSKKIDDLENHLEQSLLITEQEKPQAKIINWKVFMIILLIVIVIIIGCGIGIGLNLKDRETLSKYKISYEEVTTESNQFWNELVKQRESVSISGQDGANDIVISLTNESMWFYGDTSLTNGGFLSNSGMMIKYNGTDYEINYYINPDNGNPGPIFEFTKSEDPSKLGIWPHSGTVINDTTYVYVEFVSRKDYDLWPKQKNFYGMYSAPVGTLNFTRFLQSSDSYPLIPDALILDSQKEYYYAYFIQRPTLPMGGAYLARIHAEKITDPSQPYEFYYGGSKFSRDPKMSIQNSPPISTGVFGQTSACWNKYLNRYVLFQVGVPGKMNSIYVRTAKNLWGPFSSPYLVYHKKSSDIYYCPFIHPELFEGNGRIMYLTYSGNSDGNNRMVKITLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAH6</accession>
    <name>A0A9Q0LAH6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAH6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="303" mass="34638" checksum="72DDC5A1EE7B15BC" modified="2023-09-13" version="1">MDPYNQQGNIEPQTVDSNTFGENPYYQPNENPYYQNNPTQEYEMQDINRNPEPTFGYDYNIDVPKPPQYETELYQEQQNPNAYSTEKFTDLKKEKKEKKKKKAKKAKKDEEIFDPSIFQDEVENHHQYEDPPYKRQNLFLDNNFQQNYEHNRQNKTPKDPCVTKYAVGCFCGLRIFGIPLFSAGLFSFGIFSVGLLSMGVFSFGMLSLGIVSLGQVTAGVCVLGQLAFGTLFGTGQLTTGYYVFAAMLSISSKYGKDNKTGFANKIVEFPGDIAVWIILSLIFIIAFTSCVRKVLRKSPYKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAP5</accession>
    <name>A0A9Q0LAP5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAP5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="612" mass="72768" checksum="CC4C752FB00E0DDE" modified="2023-09-13" version="1">MNKKISIHLFAKSTNSNSLKNNSRKKKDSSLNIQIEDNTIHKQKNQNQNQKWVVLYLNDLLRLSRLESHVVSKQIMTYLFARYGIKLFEKCNFDYDEQLWNKKKPKSKDKRQMIKNCKNFFENLFELNVEEFKFMIAIDEYNILYREKFPDPKHILNIFKDLRNIRNGLMITAVSSSFDQDKIPYIDFQEFGVKTKRFTESEFESIFEWKRKEGTIPQYLTRDYWQQFTNAVPRVLYMVSRRYRTSKNESFDESTFLLNCGIDCIDHYKKRVRYVLQKIKEIKNPETIKQDIQLPTLICLNENITSLPEFWELSGLFETQFSSRNSNFQQKENENDRKLNQKQPSQPIEKQVVPICSWVTSAILEIFRNDGVNSVNFLCSYDIKWKALELFVLNGFQNFSSTSKQKLTLSNRNLKGKKQENPETFQISIKRIVYQDQQKSLEDISIGDLIVCYKGHSVVDFVCLSKNENQEKELFYFQVSILDYAHHDKKVDSLFKRDFKPTKQKKTSILEYYSKLSGIKLDENTSQFIERLSKQNQKKKKEEISPKEEKQEIRKNSYILPPNQYYVYITSTSNFLKSSQYSQDPVILVNGQHLNQINPFDYAFCEKVLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAQ2</accession>
    <name>A0A9Q0LAQ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="DITIMQD"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="5">
        <location>
            <begin position="1850"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1421"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1583"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1591"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1602"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1612"/>
            <end position="1621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1990" mass="235078" checksum="A384D05465CD81EA" modified="2023-09-13" version="1">MELFEDEIAKSQVKLVIDLVTPAEPHFRYFYGKESGHGPTVVFDQNSLPVFMECWYKDWRVAKIPCFSGHPMPKDNSPNFIRLNGFLRKEGNRHKAKRQRWFELTDFMITYHKQMGGKAMGTIPFSTISEIKQDQAKKIIHVITPNRTYILESDSDSSHTLWFSALSKVLDLRRKFSKQLPILKTLLQETKPQNLISIIRKEPENIKAINEFRNSGGKGVFLYFLSKTGMEGFLNELLAHKYDFNISAELLKINSQHFTDHFKKWKDPTLILNFLKVTSLSNYFVSFDVLKEWLNYFNDLKKFDIIEDLIAQDERLLQFVNAMKSKEQLEIFRKEKEESDKFRDLYEQSLSEKKGLEKQIQIITKKKEKEIQKKNKEIEDLEIKSQEETLKLEKEIKKLHESIEEKENQIKSLTESNEQNVTKFKKKKDKLTQQINELNSNYSNLQEEKETLNEKLNESISNYSNLKEEKETLNEKLNELNSNHTNLKKEKETLNEKLNKLNLNFSNLNDEKKEIETKISTKKQKISNLKKEKEDLHKTKQEEILRADSLKNSLTQLQTTHENTNKVIEEQKKEIENLKKKQKELNKDIKDLKEKHKKEIEESKKKHLETVNQHKEENEKLNQQFNESNSNYLNLQKEKETLNEKINELNSNYSNLQKEKQTLNELNSNLKEEKEKLKELNSNLQEEKDKLTQKINELNSNYSNLQEEKETLNEKLNESISNYSNLKEEKETLNEKLNELNSNHSNLKKEKETLNEKLNELNLNFSNLNDEKKEIETKISTKKQKISNLKKEKEDLHKTKQEEILRADSLKNSLTQLQTTHENTNKVIEEQKKEIENLKKKKKELNKDIKDLKEKHKKEIEESKKKHLETLKEEKDKLTQQINELNSNYSNLKEEKETLNEKLNELNSNHSNLKKEKEILNEKINELNSNYSNLKEEKETLNEKLNELNSNHTNLKKEKETLNEKLNELNSNYLSLQDEKKEIETKISKKKQKISNLKKEKEELHRIKQEEILRADSLKTSLNETQNTHENINKIIEEQKKEIENLKKKKKELNKDIKDLKEKHKKEIEESKKKHLETVNQHKEENEKLNQQFNELNVNYTNLNQQFNQSNSTYSNLQKEKEKLNEKLNELNSNYSNLQKENEKLNEKLNESNLNYTNLQEQNEKLNSNHTNLKEEKEALNQKLNELNSNHTNLKEENETLNQKINELNSNLQKEKETLNEKINELNSNYSNLQEEKETLNEKLNQLNSQIKDEKETSNQQVNELNSNYSDLQKENEALNQKINELNSNYSILQKENEKLNELNSNHSSLKNEKETLNEKLNELNSNYLSLQDEKKEIETKISTKKQKISNLKKEKEELHRIKQEEILRADSLKNSLTQLQNTHENTNKIIEEQKKEIENLKKKKKELNKDIKDLKEKHKKEIEESKKKNLETVNQHKEENEKLNEKLNESNSHLQKENEKLNEKLNELNSNLQKEKEKLNELNSHLQKENEKLNEKINELNSNLQKEKEKLNEINELNSNLQKENETLNEKITQLNSNYSNLQKQNEKLNELNSNLQKEKEILNEKSKIEISKQEKKIEENKENLNSNLKEQEKTKESEQIENTPITNQELKAKEDNENKENKTMISMDEKEIMRLLRQNIKALLNNYLEEPKVVISSNVFFKIDSDSNEALNLIKILSSIFFNNLERNSENKTETICDALKSTNTKLISNIITLVERQYIKPQETEKEVKTITISILTALNQSKLPELFTEIAGSIPILSKVYNSNAIILNQDFLKRLIHKLSKLKACFFSQKIHLETIVQSFIETIPEPPALKPSSLVLLQLTVKQITKHFSTYSENAFGDESKDPVLADLIQQNLFTNIMDILKIGFKTKAKFSQKHIWNIFETLSKSKSKDPVFQKIDGLVKSLNKQSKISKEHDLKTKGFIRACLKHKILHLVFHFLSENLGSCSKLIESYEFQFYQTRISQMIEELKPLSNYTFKTRWDFGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB78</accession>
    <name>A0A9Q0LB78_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB78"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="275" mass="32041" checksum="DFE05D160CB3C943" modified="2023-09-13" version="1">MAKTLVIIFFFIGASLGILGSLSFIITYLILPEIRTRFRLYILTLSIYNLIVDISILLPGYKGDTICSIQTFLVDFAFGFVCDWIFLISLVYYLQICRNVDIENSSKFYWISIIIIQIITTAGALVLTFTGEPETSFSYWCSDVKNSFVIFEFSIIWFCLIAALVFYSIIVHKIRKDQKINYPKSFQIKMLTLAILYIITLLWTTMERIRQVIQKVDTPNEFLVTTQAFFTPLLGFWDFIFFGLGDKFVRALLIRKFKKKKSQEIIELNQELIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBF1</accession>
    <name>A0A9Q0LBF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein rab-5c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBF1"/>
    <dbReference type="OMA" id="TWITELH"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="199" mass="22651" checksum="E9287E73079E8F4A" modified="2023-09-13" version="1">MAIASTSAYKVVLLGHTGVGKTSMALRFTQNEFLECQLSTIGAQCITKTVKLPDRNVNFAIWDTAGQERFHSLAPIYYRNAKAAIIVYDITQQETINIAKDWILEMKSQPNDIIIILVGNKSDLSEQREIKRKEAQKLADQYQILFLETSARTGEYIQELFFRIAELMPKNSNQETNEKKEIIPLSNKNTKIDKKSNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCB2</accession>
    <name>A0A9Q0LCB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Germ cell-less protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCB2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="17423" checksum="FED966D52B35A799" modified="2023-09-13" version="1">MLLKKLFNFSNPEIKIIPTKFDQFYQLADLLKIDLLKIKIEKEMEKYINQENAINYYFIGLKLGSKFICDICFKLLLQNIHEIIENNIEKLVDPNFIQNFKTLKSIQISNPEQNDYDYYYDYDDYDSLENIKNKIQKLNSKTKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCF0</accession>
    <name>A0A9Q0LCF0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5069008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCF0"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="482"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="647" mass="74608" checksum="EEE59A2E3F473665" modified="2023-09-13" version="1">MNDCLFFGSNEKPKLIKNKPNKITKPIQFKFENENENENENENQIKQISSGKFSIVFLLKNGKAIEYLRNSNQNPSKIQIENIQKINMGTQNEAVLTIEGNVFAKGLNINPKNPKEFINISSLIQDPNDRIIQDIVSGANSIYLLTSNQNVYGIGSNDFGQLGFDPEIFETTEKPVLMMKNVSKIFSGNSSRSVFLLNSNQELFGCGKNNHGQLGLGESIQETEIDKLIKIQNIPKGKIIDIQCGFNYSIMLIEDEDENPKRKLYSCGKYDYIGLGKNENTYEFTEIKSSLFENDNIVDFSVGYDHNLILTSNGKVISFGRNLYGQLGNGNTNHQSIPIQIELPKLRFNDDISNYHVSCGAWSSFLYYSPFLSFSNIEEDLINLFRRKEFCDISFKTQNGEIIGVHKLILQTIIGQDENQIEQLKEIISKKSIKEANQIFEIIYSNKSKINPKLYSEIEIDFNLFGSIEEKMKELIEYEKEKDFIIERKEKQYKFPKLILIMRSGLYRGMFLSVTDDKSNKVTDYSELSNKSFEIFEYWIYSNQLKEGIEITQEIIDEIKIGIDYFQLNQTHPNLFDLLINKFNNQNFNLNSKFLPNPNPKPKVKEKPKTKVKPKPKVKPKPKLKGREIRKPKAKTKIKTRKTQKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCL7</accession>
    <name>A0A9Q0LCL7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCL7"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="441"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="575"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="609"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="643"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="677"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="711"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="745"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="779"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="813"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="847"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="881" mass="101584" checksum="2F67EDD1ED71B384" modified="2023-09-13" version="1">MNKIYEIIKENEIEKLKEILKENSKEIKEKEKKKIIKYSIKQKVNKEIIEYLITKEIKDINFKDRKGRNLLHISIKKQNKIEIIKLLISKRININSKDKKGKTILYYSIKYLQNQNLIEIIEYLISKGININSKTNENETILHYASKYNSLQNSIQVIEYLISKGININSKTRANETVLHYASKKNSLEVIKYLISKGININSKTKWNETILHFACKKNSLEVIKYLISKGININSKTRANETILHYACKKNSLEVIEYLISKGININSKTNRNETVLHFACKKNSLQIIEYLISKGININSKTRANETILHFACKYNSIEIIEYLISKGININSKTNENETILHYACGYNSLQIIEYLISQGIDIHSITKWNETILHYASCRYNSSLEVIEYLISKGIDIHSKSRENETCLHSVCKYNPKLEIIEYLILQGIDLYEKTNYNETILHLACRNEPSIQIIEYLISKGLDINSKTKWDETILHLACQFNLSIEIIEYLISKGLDTNAKTKEDETCLHLASWNTSIEIIEYLISKGIDINAKTNQNETALHFVCQYNSLEIIEYLISKGIDINAKTNEDETVLHYACQFNPSIEILEYLISKGIDIHAKTRENQTALHFACENNPSIEVIEYLISKGIDINAKTIYNETTLHLACRYNPKLEIIEYLISKGIDINEKTNRNETALHIACKNTTLLEVIEFLVSKGIDINEKTNRNETALHLACEYNSSFEVIEYLISKGIDINAKTNQNQTALHFACEYNPSLEVIEYLISKGIDINAKTNYNETALHLACRYTPSIEIIEYLISKGIDINEKTNINKTALHLACEYNPSLEVIEYLISKGIDINAKTTRNETVLHYACRYNFFQIIEYLISKGIDINAKTNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCN8</accession>
    <name>A0A9Q0LCN8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCN8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="251"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="50615" checksum="34D4191CF3604B19" modified="2023-09-13" version="1">MDNNNNNNQIENANQNQNENEMKNLEKKFINQFYLQDLLFNESLRQESLSISLNQFNKKRNGINFENQRLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIENKEKEIEDKNKEIENKEKEIEDKNKEIEDKNKENQEQKQEIEERWKKEVDDKNKENQQMKIEIEEKWKKEVENKEKENQQMKIEIEEKWKKEIEKMKQEMELQKNFPQFSDSEIIQDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLIIIKTKDNFIFGGFTQVGFKHSNAEWINDSNAFIFSLRNDKGDRIPAKFTIKQPQYAILSALSNGPWFGNGSDFLLNSDLKTGQSNFGKSYNLPNGITFDTDSGKSYLAGSLSSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCV8</accession>
    <name>A0A9Q0LCV8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCV8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="214" mass="25910" checksum="DF7A6A5CCBBC0843" modified="2023-09-13" version="1">MIRKLKMIMKIKIKIKKIENQNQNQNQNQNQNQNLNQNQNQNQNQNQNQNLNLNQNQNQNQNQNQNQNQNQNINKTLDYSKNKLNLYRTQICKEIIQNPGILFKKLLDIFIVVHPADLYRLLISLELDCIIKAYFIKHSFNPFSINEDDYIFENLELFNDRFDFSEDVYNFCYFPCQNALSKLYEIEEDLKKEKQKEIIKIEKKKYHLRSKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCZ5</accession>
    <name>A0A9Q0LCZ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCZ5"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="147" mass="17829" checksum="3B16FFA4CC38EEB4" modified="2023-09-13" version="1">MIYSNKIINPKLYSEIKEIINSNEKIEETMKRIYLIENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKEIIDEIQIGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD22</accession>
    <name>A0A9Q0LD22_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD22"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="266" mass="31340" checksum="6FE06625E1B866ED" modified="2023-09-13" version="1">MPTTLVIICCCIGASLGILGALSFIITYSILQEIRTRFRFFILSLSTYNLLVGISVLLPGFKQKTLCSIQVFLTNYSFGAAYFWVFEIALIYYLQIRKGYDFENSKKFYWISIIIIQIVCLVFGILTVALGNPTKETSYWCTISKRWLMEIEYSLVTIFLIGSLFIYFLIIHKIRKYKDGNYPKTFQTKMLALAIVYLLTELWNIIKRVWQIFQNTKNSNDFFDATQAFFTPLIGFWDFVFFVWGDKFVWALLLRKWKKQNYDELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD56</accession>
    <name>A0A9Q0LD56_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD56"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="325"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="494"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="596" mass="69899" checksum="4875EE05DB8D010D" modified="2023-09-13" version="1">MNDCLFFGYNKEPILIKNEPNKIIKPIQFKFENENENENENENENENENENENENEKQIKQISSEYLNENDSKQNPEKIQIEENIQKVTVDYRNEAILTIEGNVFAKGKDINPKNPNEFINISSLIEDTNDRIIEDIVSGGFSFYLLTSNQNVYGIGSNYFGQLGFDSETLKKAEKPILMMKNISKIFSGISCYHVFLLNSNQELFGCGNNENGRLGLGESRKEETKIQKLTKIQNIPKGKIIDIQCGVFHSIMLIENENENENENENPKRKLYSCGYCRYNGLSKENEDTYEFTEIKSSLFENDDNILDISVGDSHNLVFTTQGKLLGFGRNLFNQLGIVNTQDKFIPIQIELPKLRFNENISNYHISCGYRNSFLYYSPLSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIEELERGIDYFQLNQTNPNLFDLLIKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDX1</accession>
    <name>A0A9Q0LDX1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Otu domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDX1"/>
    <dbReference type="OMA" id="NEYQINT"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="309"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="448" mass="53628" checksum="2609C7CE6FE5A46D" modified="2023-09-13" version="1">MLSLSKIKQKHKIEQRNLTKQINQMKKKVSGKQKKTIQNQIEEMKLNLEQKQKKELEEFYSTNPEENENENENEIENENENQNENENQNQNQNENQNQNQIENENQIENQNQNQNQNENQNQNQIENENQIENENENQNQNQNRNQNRNKNKNQNQNENQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNRNRNRNRNKNKNRNQNQNQNKNKNQNQIQNQNENENENQHSLYNEYQINTRKNRKQKKQQQKKEKEKKELEERLKNAKETRGEQETKALLNILKKEGMKIKQITPDGDCLFSSISDQLKYYNISQKTAEKLRQETSVFMGKNPDLFMPFMLNSKNEPMNKEDFEKYLLKLKKTKMWGGQMEVKALALLLQCEIIVFQADSPQQVYSVENSKATLRTAYHKYLLSAGGHYNSIIPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFD1</accession>
    <name>A0A9Q0LFD1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFD1"/>
    <dbReference type="OMA" id="AFCIIKL"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040337259" evidence="5">
        <location>
            <begin position="17"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="7">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="129"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="65851" checksum="45621895B05AD700" modified="2023-09-13" version="1">MNYFLIFLICFVFVVSTNHYTENEVELLFSKFKSDYQKSYLNPNEEAYRKAIFEEKLNLVQEHNSDPTKTYKIGINQFSDLTYEEFSSMYLSSLKYPNKKSEHEFKQESNLEDKSNNNNNKMKGGLKSNPANVDWRMDYVTDIKNQKSCGDCWAFSATEVIESALAKDTGVLIELAPQEALSCTYKDSSSSNPDVTDGYIEVPSSWISDGWQTGCDGGNACDVFQLYALYKTITSSQLYPYADADGICQTYTNYVELSSNEVYEWGGGCNKESEATLETLVANNGPVSVAIYASSTLELYTSGAFASTDCYVNGETNHAVNVVGYLNNYDGYPVWIVRNSWGSGWGQNGYIYIRKGLTSYDGTSYPYGMCNIGMYLIQPQKPITSTLNSFGPVSNFDCSSTSTSWSCSWDSLSGATSYRFYHSSDGTKWKAIMNETTSTSFGNTEDPTNVYVAVRPMKSTSNYNQYGVLTDWSSVITPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTTSSSPSPSPSPTPSTIPIKVETSSTNTTIAAVVVGVPVVVIAFVMIILIKRHKKKTSYRYPTSEKELQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFV9</accession>
    <name>A0A9Q0LFV9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFV9"/>
    <dbReference type="OMA" id="AAYCVNP"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000044">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="331" mass="36586" checksum="31BA294DB69057B4" modified="2023-09-13" version="1">MNFSLTYDKETKELIQNRINFTSKRINILPEQLRAVFPHLLETEMKFKMNEDISSYIDHTLLKPDATKEQIKQLCQEAIDNKFYAVCVNSNRVKEAFEFLGKNSVQLAAVVGFPLGVTDTNCKIFETETAIDNGATEIDMVINVGRLKDEEYFEVLSDIREVVKSVDESVKVKVILETCLLTKELIVDACILSVIGGASFVKTSTGFSQGGAKVEDVRLMKLVVGDLAEVKASGGVRSYEDAMKMIANGATRIGTSSGVKISKEKNDVKQNQIDSISDQNLNRNSSSSSFVNPKIALCGAFLTAAISGFFAGYVYQQNSQNSNKKNPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG29</accession>
    <name>A0A9Q0LG29_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U2 small nuclear ribonucleoprotein a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG29"/>
    <dbReference type="OMA" id="PNYREYM"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="234" mass="27541" checksum="5F8F3C1281C8078C" modified="2023-09-13" version="1">MPRLTVELILSSPSFTNPLNQRELTLRGNRISTIENLGSTLDQYEAIDFINNEIVKLDNFPLLKRLETLLLTNNRISKIGRNIWENLPNLQSIVLSSNLIADFEEIDNLSGFKNLSRLSLQNNPICLKDHYRLYVIYKIPSLKTLDYRRIRLEERKNAQKMFANENEKKFLIKKEKETEKEIEKEKDENIPKQISKAQFQEIQKRILNAQSTQEIEELEKLLKEGIIEEDIQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGA7</accession>
    <name>A0A9Q0LGA7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pogo transposable element with krab domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGA7"/>
    <dbReference type="OrthoDB" id="6609393at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="103" mass="11382" checksum="9ED7C62113B21374" modified="2023-09-13" version="1">MTKDLEARYSHSQVFNMDETHIVFEPEIKKTVSEKGKKQAQIKSKGNPKEGCTVVGCIGADGKHLPLTFILKGGSRVIKWIKQDISNTNLKGNCTFLPIVSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGS8</accession>
    <name>A0A9Q0LGS8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Biogenesis of lysosome-related organelles complex 1 subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGS8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5072602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="108" mass="12741" checksum="C74C9B5B323B4C19" modified="2023-09-13" version="1">MTEEQTNLKEQTKILTDSFMELFYSPVQQISLKLEEIRQKQFISTLSTFETNSEDEKKIKRINSKISQIPDYISKINKIHKEMISITKTTNKLNKTIDKKLKKSKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH27</accession>
    <name>A0A9Q0LH27_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Density-regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH27"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="95"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="211" mass="24367" checksum="77956C2442F1CE26" modified="2023-09-13" version="1">MTEALKVEYCPHCRLPPEYCQYGPCFSKCKVWLAEIHPEILESIKNIPKQTKKTEEKTEKKTKNTSNQETKQVENKKLIPNEEKEKEKGNTDGKIIISRSRRGGKKFITIIEGLSQFEVDLKKATKLFANKFSCGCNIEKDSDDTVCIQGDVHFSLPDVLLKEFKIPKTQIHLNEQITKAKKKSKKNKNNVPKHKQNRKKPTRKERLASNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI45</accession>
    <name>A0A9Q0LI45_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_09275</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI45"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="63"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5072829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="558" mass="62850" checksum="F85AA131B0807E20" modified="2023-09-13" version="1">MSHIGRFNIPTPHNEPPLSYLPNSKEAKKLKEECEKMRKEIPFEVPCIINGKEYKTGNIKEQLIPSDHKNVICKFHQVSEELVQEAVKGALEAKKKWEEMSFESRAAIFLKAADLVVGKYRYVMMAATMLGQGKNIWQAEIDCTAEVSDLLRFNLKYIEEIYSNQPKINPTAVWNRLEYRPLEGFVLAITPFNFTAIGANLPTAPAMLGNVVLWKPSSTAIYSNYIFYKILQEAGLPAGVIQFVPGTGSMIGKILLKNKDLAGVHFTGSTAVFKHIWLESAKNTMSLYKSYPRIVGETGGKNFHFVHESALIDNLVNHTIRGAFEYQGQKCSATSRMYIPKTIWPEVKEKLIKEVSKIKMGQSDGKIKFKIKIQKDPTSFMSAVIDKNSFENIKKYINEAEKDESVELICGGKYDDSVGWFIEPTIYLTTNPKHKLMQEEIFGPILTIYVYEADKYEETLELCDQTSPYALTGAIFANDREAIDIAIKKLRQSAGNFYINEKSTGAVVGQQPFGGARGSGNNQKAGAIINLMNWCSPRSIKEGFVELKDWKNGHEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LID4</accession>
    <name>A0A9Q0LID4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5073015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LID4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="136" mass="16608" checksum="D7DA170A4BBD1F5D" modified="2023-09-13" version="1">MEYFTEEKEKELKMDILKQFYISKSKKEFNIKQTIISLLDNPQIETFTIKRKEKKIFLISKIFQQLFDLLILNIQQFSFISLSKTNFLTVYIITEIFSSTLINISQISQFSRLFYFIYIMKRKKNLNYYQQQKYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LID6</accession>
    <name>A0A9Q0LID6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LID6"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="590" mass="68564" checksum="E4D39BD8FB47C04A" modified="2023-09-13" version="1">MNDCLFFGFNKYPILIKNKPEEITEPIQFKFENENENENEKQIKQISSSGFSTIFLFKNGKAIEYLSENDSNQNPKEIQIENIQKVTVGDENEAILTKEGNVFAKGDDINPKNPNKFINISSLIEDKNDRIIQNIVSGSRSIYLLTSNQNAYGIGSNYNDQLGFDSKTLKTKKPILMMKNVSKIFSGIASQSVFLLNSNQELFGCGDNEFGQLGLGESRKEETKIQKLTKIQNIPKGKIIDIQCGYSHSIMLIENENPKRKLYSCGNYQYNGLGIFDEHTYEFTEIESSLFENDDNILEISVGYAHTLILISNLKLIGFGNNYYGELGNEDIGEEDIPIQIELPKLRFNEDISNYHISCGINKTFLYYSPPPFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIKITKEIIDEIQIGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ15</accession>
    <name>A0A9Q0LJ15_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NNGCGAL"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="66"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="149"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="192"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="235"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="280"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="364"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="407"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="536"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="579"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="582"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="622"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="665"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="708"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="751"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="794"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="797"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="880"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="966"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1297" mass="146777" checksum="56886341CB9F52BF" modified="2023-09-13" version="1">MEQIQKQIQQLLTKINEKDEKIEELEKRLNEVTRKFENQKTKTEEEKKAENFLESFLKGKEKSTSIQEIIKSMNQFSLNEKIQENGCFALNKMITENKEEEYQNLQGIHTIIKAINNFPNNQIIHEKAISILDVIAINSENKIEIREMKGIEAIINSMNSFPNNQNIQYQSIRVLNKLSLNQENGNEIRKSKGVNPIIRAINNFQNNQQIQYEGCGILWNISINEKNQIKIRELKGIESIIKSMNNFPNNKDIQNSGCGALLNLAINKDNKIKIRELNGIESIIKAMNNFPNDQNIQNNGCGALLNLAVNEENQIKIRELKGIESIIKAMNNFLNDQNIQKQGCWGLLNLAVNEENQIKIRELKGIESIIKAMNNFPNDQFIQNNGCWALRNISVNDNNKIIIMEINGIESIIKAMNNFPNDQIIQKQGCGALSNISTIKENQIKIRELKGIESIIKAMNKFPNNQIIQKQGCGALLNISAIKENKIKIRELKGIESIIKAMNNFLNDQIIQKRGCGALLNLAVNERNKMKISELNGIESIIKAMNNFLNDQDIQKRGCGTLSNIAFNKENQIKIRELKGIESIIKAINNFPKNQNIQNNGCGALLNLAVNEENQIKIRELKGIESIIKSINNFPNNKDIQKQGCGALSNIAFNKENQIKIRELKGIESIIKAMNNFPNNQNIQNNGCGALLNLAVNEENQMKISDLKGIESIIKAMNNFPNNQDIQKQGCGALSNIAVNKENQIKISELKGIEPIIKAMNNFPNNQDIQRQGCGTLIYLAVNEENQIKISELNGIEPIIKSMNNFPNNQDIQYNGCWALSNIAVNEENQIKISELKGIEPIIKAMNNFPNNQVIQKQGCEALIYLAVNEENQTKISELNGIEPIIKSMNNFPNNQDIQKQGCWTLSNIAVNKENQLKVAEFNGVEPIIKAMNHFPFNQDIQYWGIAALSNISSINQNQIKIGELNGIKPIIKAMNNFPNIQDIQNNGCSVLRNISVNDKNQIRIRELNGIEPIIKSMNDFPNDQVIQKQGCWALLNLSINKENKTKIRELKGLRAVIKAMINFSDDQAIQKLGVETLFKTSAINNENKIKIREANGFESVIKAMNNFPNDQVIQKWGASILSNIDISNEIIIKISDLNGIEPAIKAMNNFPNNQDIQKQGCGTLLNISINEIIIIKIRELNGIEPIIKAMNNFPTDEDIQYWGIGALSNISLDDENKIKIREFDGIDRIIKTMSKFSNRENLQQFGCWALNNLAFNPENKNIIKKLKGVELIKQTIKNFPNNQSIKEWGKATLKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJG2</accession>
    <name>A0A9Q0LJG2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitogen-activated protein kinase kinase kinase 20-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJG2"/>
    <dbReference type="OrthoDB" id="2350515at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="323" mass="37724" checksum="CA1F2C0D1A80549B" modified="2023-09-13" version="1">MHQFLEEVLLELFIKLHLENQENLMHSKYSKNDSFNLQEIQTLKKFSFHPNIIKILVDLSTKTKQAYLMEYFPLGSLRSFLKKTKDISFQTRFNIMSDICTAVATIHKSGRVIHDLNCDNVLVTIDQHAKLCDLGLVEKIPKNNYEEYALDIRYLGIIFWEIGFNELYEKCTCEDPLKRPTISQVQDLLIQLKEKMECEKKPKKKLERTRSKKKLKSKNNSRSSSAKIPRGILRGRPAPSPIRLRSNDLVIEVENSNLDSNVNFNKLNDYAKPKTRRALTPRFQKKTKTWRNVEETIVQIQKTKPSLLSQSNLSIEKLKEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJG6</accession>
    <name>A0A9Q0LJG6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJG6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="84" mass="10444" checksum="B3C84BF61CA5FC91" modified="2023-09-13" version="1">MNELIDLYKTLLEYFIDPCEKFIQNLKTSFTSTKKRKTENIFSFPDYALSQRLTKFFKELKLKYIIHLYRICYKIYQKKRRENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJH2</accession>
    <name>A0A9Q0LJH2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HSWINIS"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1545"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1627"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1685"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1732"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1758"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1788"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1820"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1976" mass="223022" checksum="0D18BCEBD94DC017" modified="2023-09-13" version="1">MVNLSDFYDGDTYPLNCEIIYNFTGTLSNVSNVTFYCTSDECTPLTLEGQINIFNSQNVIFDGSNCSKLEIKAPISISSNSNVTFKNTSFYYPNKLISEDSIVYLDQFYLENATMDSNPINGTNSVFVISNLGINGNWSTLSFVSDQEVTNSSTTINNCNGNFKITSEGVPLQISSCSDIDILIKNSQLTINSTEITLYQVKLDNSNFQMQNASIFNLTVFGNSNISGTFLEISELLYFGADEEAQSFVFVPTSISSNFTIEENSSVFFDYLTLETGSEFVNISGKIGINYQFTTNFGNYVIPNLFLYKSSLLKCIYSTLEINNTLSFYGNLEDEKIINCSLNFTGKELTSESTQVQIQKKFSISPTGSCQISTNDLYLIVNNSVLEANYQMNLSRLDFLYNTILNSTLYPQLNVNITLFIGNSTIQNVDIYSNSVILLEYGLVEFQDDTNLYSLKATSPEHSNYTLYGNGSFHTNKLEVEGDLDIDEIFFGKEIEIAENGKLFLSDLTSNSFSQINITLNGSLTISNSSIEDPFDIFIFYSQNLYQLNFIDSQFNFNNKQFDLPNLKLENSNISYLQSNLSSLLLEGLNLFQNSTLQIQDGLIQAEESQTSTLYLNSSNFTFGNNSGFNLNSSSSISIYSFPNSQNFNFSSLEEKNQTFIISFDSCLLLDNVEIEVVGDDRVDFSGELYISNSIFTINSSNIYFGKLEIVGINSEVDLQNDINIQNLTFSSGKLNFTKIISNNSNSLFIFGDGTDQTFFNEGKTSQANITSSGSILIKNNISFPNIAFQLENTSNLNIQSLNFTTSSNSSIINNYGKISINGLDQINSQSSPINFGFFTKNYQVSEINCSGNTKFSQIVVNYGKIQTSTDLSFEMNLFVEEGGMINGSGNEKPNIVVNEDLYITGETQINFVDISANQTKFISFSNHSWINISNSNFTTQYFIFDTTQILSEQTIFTVFQETQFFKDCLILPSDLEQPTTSEFWNNGDFVVDSRNVTFLLTLKNYGSFSANSSFITFSSLENYNKLNISYSNIALLNDSLVSNSSMNNSIEDTQANYFINSTINIKNESSNLYFQGQVKFENGIEIYGNFTIKEDADVILELEKESTQMIIHNTSTLQSPLWLVLLRSSPDEARNYSYNAIYLVNNQTFNMDMLNSTDEQHINFSRNNEWITAIVAGCPQGEYSSGFDKTCHGCGEGNYNDIIGASKCQPCPEGNFSNQTGQSQCQPCSPGSYQQSTEQTSCSLCEIGTYTSKNGSAHCIQCQQGYYNTENGSTNCSVCKKGYYSQLPSQCIPCPTGEYSSIEGSFTCYYCPAGSYSSKEGASSCSTCPSDTYQKEIGQESCIDCPTNSGTSGVGSSSEKDCLCSIGYYGEYGSSCKLCPSGGICDDIGVVVPDAEPGYWHSSSDPTSFFQCAVSAACPGGGTDTCNENIGYSGNLCAVCLSGFYKFGGECMKCPQNQNNRLILMSFFVILLCLFLFIIARKVKNYFASFSIMFSFFQVLAVIAGLKANWPDSINSTWRSLSVFNFNIDYLAVECTVPLTYTQKWWICMSFPFILFFVLLFVYLVVFLHSKTIEKCGSKFMNKFPSFCERPTRQTTNKYLYIFSWARFKFSQLFTHGFGREQRKTLYNNLINSYSTILSFLYLFLSYKVLQVFDCRKQSSGVYLFEPDTSLFCYHEWWMRLLPWAILFFVIYVVGIPLTLAILFFVSSKKMDEKTFDLHFGLLCARYTKRWFFWEIVIMIRKLFMTISQLFFSFDAILQLVVSVVILLASLVLQVQTKPFVSNRHNTLEFVLISFSEIILFSGMVFVSNDLQSSRANNILAIVIISLIWISLTVLVFMILFEIRHRLRVKKGRDVDEIQKSVELSSGKTVINFLASKPSFFLIWNWVLQNTDHKAKLLREFYKQIKDFYSKNESQKEMLNIEEFWKSFLEKWNPFLLQIIQNWFNQASLLERIQFANILSKIRFEIFLNNSNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJI2</accession>
    <name>A0A9Q0LJI2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aurora kinase</fullName>
            <ecNumber evidence="13">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_01334</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="13"/>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJI2"/>
    <dbReference type="OMA" id="HQTINDM"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="233"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="156"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="10">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5072320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="491" mass="57050" checksum="2775F3ADF476345B" modified="2023-09-13" version="1">MTNKSGLILPFKQKILIPKSLVNPNNENEKINFPNRSLSNLNQKQKQKQSSIIKKETQQIKSKKFLTNFPNIKTNEEKGNQNTQTKSKEQKQIIKSKPPIRIKPIYSISNSIPNSNYNTGKNIIKKNKTSSFIEKSKQKPKLNINLNINKDMNKDINKDINKDMNSNSPNQVTQIKKEKEKEKENNQEKEKEKEKDKDKEKEKDKDKDKDKDKDKDKDNQKNNQKKRWQISDFEIGNPLGKGKFGYVYLAREKQSKYIVALKVLMKSALHRDGILHQSKREIEIQSHLRHPNILRLYGYFYDKKCVYLILEYAGNGDLYKELGKRGKFDEKTTARYIRSVASALLYCHSKKVIHRDLKPENILIGNDGELKIADFGWSAVSPDSTRLTMCGTLDYLPPEMIAGKEYNEMVDVWSLGVLMYELLIGNPPFEAKCQNETYRKIVDAKLHLPKTLSSDARDLIKKLLVRDPSKRIPLENVLKHEWIEKNSSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJK7</accession>
    <name>A0A9Q0LJK7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_01608</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJK7"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="441"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="498"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5072593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="700" mass="80733" checksum="F26B118CAF4892DA" modified="2023-09-13" version="1">MDHKRISYFYDEDVGCFYYSSGHPMKPHRIQMAHELIVNYGMHDKMQIFRPPKATRQDMTLFHSEEYVRFLETVTPDTTQEFVDQIRRFNVAEDTPIFDGLFDFCRISAGGSVEGATRLCQGFADIAINWAGGLHHAKKNEASGFCYINDIVLAIIELLRYFPRVLYVDIDIHHGDGVEEAFYTTNRVMTVSFHKYGNFFPGTGALNDIGVGQGKHYAVNVPLDDGMNDESFTSIFNPVMTEVMERYRPAAIVMQCGADSLSGDRLGRFNLSLYGHGDCVSFLKQYNVPMLVLGGGGYTIKNVARCWTYETSLLVGMQISNDLPENEHHDYYEGNKLHLITTNMANSNTKQSLENIRISISESLRMLEGAPSVQMTFLPPETRISIDRGLYDDIDEDTYPDIRITQKMIDDFIARPEELELDLELTTAKLLQKNRNVQAFSLSDSDSERDFDEDLDDDDDSDDDDSVGVEDERSSDVVVTSENDSESQNLSDSDAIQIENQNQNQNQIQNQNQNQNENQNQIQNENQNQNKIENENENENENEIENQIENQIEIENQIENQNQIQNENQNQNENQNQNQNQNQNQNLNQIENQNLNQNQNQNLNQFQFQNLNQIENQIENENENQNQIQNQNQNQNQNQNQNQNQNQNQNLNQIENQNQMEIQNEIENNIPFVNDSIDKNNQIGNQNGNENIEEFKRRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJU4</accession>
    <name>A0A9Q0LJU4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJU4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="160" mass="18968" checksum="9B62D82B683AF397" modified="2023-09-13" version="1">MDNNNNNNQIQNANQNQNENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILNSISKQDFDKLKQFDSFPKSFLVDIQNKVIQDNQKEIEEKWKKEVENKNKENQQMKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL29</accession>
    <name>A0A9Q0LL29_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication factor c subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL29"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="335" mass="37912" checksum="89F697F5CA4EF3FF" modified="2023-09-13" version="1">MQIENENEKQKKEHQNIPWVEKYRPKNLNEIVGNEEIISRLKIIANEGNLPNLILTGSPGTGKTTSILCLARQLLGNSYRKYVLELNASDDRGIDVVRSKIKMFAKSKATLSEGRHKIVILDEADSMTEPAQQALRRTMELYSETTRFALACNFSNKIIEPIQSRCAIMRFGKLNDSEIITRLNYLIEQEKISVTEEGLKALIFTADGDMRQAINNLQSTFVGFRFVDQNNVFKVCDIPHPGVVESITKECSNGNIKEAQKLLVSLWNEGYSATDIINTMFRVSRKLEIDEQILLEFLRIISNTHLRIVNGNGTLIQLSGMIANMCKVGLTKKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLD6</accession>
    <name>A0A9Q0LLD6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription initiation factor iia subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_07990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLD6"/>
    <dbReference type="OMA" id="CICTALS"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5074635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="179" mass="20664" checksum="B68D68699A4D5366" modified="2023-09-13" version="1">MTNPNQSNYELYRRCTLGECLNETLEEFLNDKKITSSLSAKIQNNFDVSILNALTKMTTTTLSLKGKVDQYKNCLNVWFFHVSNMKFNLDKIGEIDSKKIKIVSMESEDTKSTTQKNKKRTKDNKKKPKKKKTKKKTKKKTTKINSDSFDSQIDSDNDNKSESANEKENDSNDFSDDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLF3</accession>
    <name>A0A9Q0LLF3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol-4-phosphate 5-kinase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLF3"/>
    <dbReference type="OrthoDB" id="423343at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="39"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="175"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="787"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="941" mass="108700" checksum="C6FD2CB49DF6DD8C" modified="2023-09-13" version="1">MTNPLAKIEDSLQTTKIQTSQEPKIQEKEITPTETVNLTLGFVLEDKLCRAYFQQYLREQFSYENMGFYYAVQKYRHLETDEMRNSFGKKMFDTYISTESMQEININSEMKKKINQTIENEGYTKTLFDESMDHIMGILETHSFPRFKQSQHYELLLKDLELIQTGKTPHGPETQRDQAFNSIYTMKQQLSSKLNDYAQEFETLDPNENSQQENTVMKEIRRIYVQIRDVEMAIAKDLQKKQTQWNYEQILSDVFKNASQQYYKIYSQYFKIFTQIEPNIESLVDQKHPNNAFKRITKKYLCDIKCVLSLPIDELMKFENLLFKLVESTSEDHPDIHELKQFTQEFHEFVLFSAQERVLQSKIVESNLYLFKNRKLLKEGIGKIIKYAQDPSLNGVSFQLLLFEDCLCWAVSETRDQSTPTEDQETAKKIKFIVDEILPINLVWIKQGIESLKFLGESVFQITSPGIELAVSIPGTSEWITEIAAVVAKSCGLDSRDVFSSPERKGTFYQPDRSRYIGTLKDGKFHGDAKIIYPNGSVFEGNFVENIKSGPAKLTFPTGDILTANWENDFPSGLAKITYKSGTVISGNYSDGFISGPGKILFCDGSVYEGDFDKNKMNGKGTLIYSNGDKYQGEFKNNFRHGQGEFHERDNQIYNGDWAYDKREGNGKQIYSNGNVYDGGWRKDLPHGKGIYISKTGSKYAGHWNLGQKSGFGRLDYSETKYYEGEWVENLKSGKGILYNGTIHFNGEWDDDLPNGFGTLTIFPDSKQEKSKENEKENENENENENQNENNQNENQNENQNQNQNENQNENNQNQKENQNKNKKPPIDISKDFYIQKVLGNFKNGFPDGDNITIEIRNKLKIRAQMKMGKLNQNCTITFWNGTQIEAYFKLDTLDITKPISFLIPRELDKIFAIDQQNETKAPPGISFWLLPPKDPLLNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLQ3</accession>
    <name>A0A9Q0LLQ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tobamovirus multiplication protein 1-like isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLQ3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="320" mass="37272" checksum="86D57BE8298B4049" modified="2023-09-13" version="1">MVSALEMAKRRARGASGTGSPQLYVIGIISAIVALLVFYEIIRTIRITGSTWKNLTSRFRILILSSCFLELALISVLFLVSFNWKSVFPLLFLYDALPSWFQFCTFAFYTLYLAKTLYMIEGKQTKTKKYLDFIFAMLIIFSFAFVFLVSYFDSKYLEDEDKYKGSDILAALYLAILILPLLILFGIMGVKYYKKSHDYLLLLIQKERIKYVMLLIIIDGLIFLGFFIWSLFSAFGGNKIQKNVDDYLENKEYSKYDTFALIFGLIFFIIPAFVLFIILHRVLSNEKGMFQREENILLTDLDDDNDDNFNSEYKLFDVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM21</accession>
    <name>A0A9Q0LM21_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cop1-interactive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM21"/>
    <dbReference type="OMA" id="NDYEANQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="524" mass="61710" checksum="BE207F499C455B64" modified="2023-09-13" version="1">MVNTINKYEKQIQEKEESINQLNTKSKKEKDNNKLIKSNIEKLNLQNSSLQEDNQKLKNQIQKIKEANKKSKNNSVQKYKQLAQEHEKLESSFEKIKAQNQEILTQSEILKKTINNKDIQNSQISQELTQSKSEIEQLSKYKQNLEKIRNRNSKLKKQKQDIKNVLLQVNEKNQKIQESFEQLKIRNEQLLNEKEEQQIAYQKELENTKSSWDQELQNLQQQYENLNSKSIESQKRIEELEKEKDQISEENKSELENKSQIIESLKEEIDKSVFAKKQEIQESTQNLQKITNDYKELENQLLEMKSKLIFFEKEKEQNFQTIFQLNQEIQELKKNEEKLKNILEKNHLKSKEKNSFQIVENKNNNNQNINTINTEVANTSQNNMQNNNQENEISNKEKNIDLMNANSDLEEKEIDQKIEMKQLKKRIQQLEIQNQELKQKVLSYRTKSKTISKAKTNSKAKTNTNSKAKTNPKTNTNSNSKTNPKTNTNTNTNTNSKINPKTNTNINPKINPKTNTNINPKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM43</accession>
    <name>A0A9Q0LM43_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM43"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="268"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="435"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="550" mass="64769" checksum="8697DE5FCFB1D23C" modified="2023-09-13" version="1">MNLFDNQKNEIIFFGRNEYPTFYKNKSNEIKKPIQFKFENENENENENENENENENENEKQIKQILSGKLSIVFLFKNGKAIEYLRNSNSNQKPQKIEMKKIQKVSVGWQNEAILTSEGNVLVKGESISFDYPNQFINISSLIEDPNDRTIQDIVSGYSSIYLLTSNHNVYGIGSNEYGQLGFDSDSLKFFKNAFFFLNSNQELFGCGYNQYDQIGLGKSFIEYRFNGLGKNLYTDEFTEIKSPLFENDNILDFSVTYNHTLILTEKGKLIGFGSNCFGELGIGNTEDQKNPIQIELPKLRFNEDISNYHIYCGYHRSFLYYSPSFSNLEEDLIKLFGRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENNFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKKGIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLIRKFKKQQRKALFSILFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMU0</accession>
    <name>A0A9Q0LMU0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMU0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="334" mass="40001" checksum="C8502B02354C6B92" modified="2023-09-13" version="1">MQTPVTLITVKKGKPKLQYKDSNQETKEIQQIFESNDVHIYTFILLEQELNYTFDTETNEKEKEKEFKQINIKESNIIFDFDEKDSKKYGTRVIDAVIDYSSPSEKKIIKEKHWEFFFEFLNQFSKKGFQTKQSSKVTFKSKPENIAKILFVLGLRYSKSTLKKIFKENLEILFSFYVKYHFKLSELSKEVLIKIFGKSLNFENTIWFNFINTILKKELMINLFLIPSFQDNLKNTIFPNLLDCFQFWMNFYNFVTSAEMRKIRSLRSAIMQIASIFPDIVDYSLFNQPCLKNEKRSYIEKLSDLVTIFKNKSYYEYSNKQIKNNDERLNFLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN11</accession>
    <name>A0A9Q0LN11_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein restricted tev movement 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN11"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="359"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="582" mass="68884" checksum="E07F294D735BA5C6" modified="2023-09-13" version="1">MNFNQSNSNIPILSPIFKDKQKFLLLFQKTKVEIHHVLSSIGYIDNDKISEYYKWLQPLKNREELFALLLNYSNPKNLNLQEIPNHLDTLKKSGILDYNILLQSSYNYVKIKLQWNSLTIPFSQINFEIKPLNHLKLAQQKIEKTENAVQIVIYDLISLSKCALHIWITQKELNFQKIEQIEFPLKLIDATIFTTINKMNTFLNKMIQELRNNDSNMAEETTESQDYKQMLDEMLIQEDAFFNYKNTISEIKQEAQKQMRQVEFCEMKIRENANWILSVFDACLQTSNSISKISSGIEPKNIPILEKAAQDFKKSQKDFGKLSRSYSKWKTIARNFQKAVVMYCKYYVQQTQILQPEMYDQLQEMITKTSQKLNEDRAKIQTQEELEQFQKEIAKLQAVCLQRNCIVKKLVNVDIDWEAFLNDDKFFTIGNDMDLFQIIDNLSTMSFADFSQHYLQVFQDLENKQNNQQSNLSNSEQKSKFDNVYDKLKQMESLKLNLVNFTNQIRDFKSKLDANKKLMKENKANLVKKKELKNEKKQIQKEKREKKKERNSILQSLKELVPFFPEFSLDEMEDILLFLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNQ0</accession>
    <name>A0A9Q0LNQ0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNQ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="494"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="608" mass="70914" checksum="B53D955B06A0D5BA" modified="2023-09-13" version="1">MNEIIFFGYNQYPKIIKNKPYSITKPIQFKFENENENENEKQIKQISTGSYATIFLFENGKAIEYLNKNDSKQNPSKIQIEENIQKVTVGNRSEAILTIEGNVFAKGENINPNNSNEFINISSLIEDTNDRVIKDIVSGYNSIYLLTSNQNVYGIGLNEFGQLGFDSETLNKTEKPILMMKNVSKIFSGNSSEHAFLLNSNQELFGCGYNYSGQIGLGESRKETKIQKLTKIQNIPKGKIIDIQCGVSFSIMLIENENENENENENPKRKLYSCGYYQFNGLGKEYQNTYEFTEIKSSLFENDDNILDFSVGYNHNLILTSNSKLIGFGSNKYGQLGNRNTKDQLISIQIEIPKLRFNGNISNYHIHCGYNNSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNEIEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPILYSEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVRDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIKKGIDYFQLNQTNPNLFDLLINKFNNQNQKKNNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPF1</accession>
    <name>A0A9Q0LPF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small gtpase rac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPF1"/>
    <dbReference type="OMA" id="RIRYLCI"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="22555" checksum="90919C0D2157F704" modified="2023-09-13" version="1">MNKYNITFIGNDGIGKTSLLMTYNDKKIPEKYIPNLSESFTKNFKIENKEFEIEFWDSGHTSDVDRIRYLCINQSQLTAICFAIDNLYESFESVENRYKYEVKENAPKNSKIILIGTKIDLRNKLKEENKKLITKEEGIEMAKKINAIKYFECSSFNQKGIETIFNEIALICFENFEKYKEEKENKKGCILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPS7</accession>
    <name>A0A9Q0LPS7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaerobic glycerol-3-phosphate dehydrogenase subunit b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPS7"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19946">
        <property type="entry name" value="GlpA-like_Fer2_BFD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="entry name" value="2Fe-2S iron-sulphur cluster binding domain, sarcosine oxidase, alpha subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051691">
        <property type="entry name" value="Metab_Enz_Cyan_OpOx_G3PDH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42949">
        <property type="entry name" value="ANAEROBIC GLYCEROL-3-PHOSPHATE DEHYDROGENASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42949:SF3">
        <property type="entry name" value="ANAEROBIC GLYCEROL-3-PHOSPHATE DEHYDROGENASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="511"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="713" mass="78449" checksum="1997464BC7B0FF0E" modified="2023-09-13" version="1">MLSPIKPTFFLNKKNNSLLQSNFNRFIKTGAKRILEHPVLEIPQRKEVSFQWNGKILYGYEGEMLSSALIANGEDIFGFHYKDKSPQGIFCANGQCSQCMVTCNGVPVKSCMTPLKEGMVVNYAAQVLPEFREKLNLKDAPKSEIDVLIIGGGPSGLSAACELGKKGVKTLLIDDKDRLGGKLVLQTHKFFGSSEECYAGTRGYKIGGILTKEVEKYSSVQVALNSTAVAVFSDKYVGIVSNGEYKLVKPKKLLVAAGAREKFLSFPGNTLPGVYGAGAFQTLVNRDLVRSSNKVLIVGGGNVGLIGGYHAIQAGIEVVCLIEAMDHCGGYKVHEDKLRRLGVPILTRHTIVGVTGKDHVEKCTIAQLDNNWKIIPGTYKTYDVDTVLLAVGLEECKEFYKKAQNYGIDVFSAGDAQEIAEASAAMFTGKIEGRKILKSLGIDIEIPEDWDEKVKVLKSKPKDTDEKHITELTEGVFPVFHCHQEIPCNACVAGCSLGNISMGEENDIKDPPIFRGDCDDCNGCLRCVTVCPGLAVTLVDFREDAEFPTVTFPYEVWRKDVEIGKMVPIMDEAGLMLGKFKVENVQQRERTLLVSVKLPKDIAKKAASVFTREIKQIPDLYEKSKFPDESIVCRCERVSAKEIRDSIRLGVTDMNQLKAATRACMGACGSKTCFSTIKRIFREEGIPNDRITDRVERPLFVEVPLGAFAGMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ76</accession>
    <name>A0A9Q0LQ76_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-related protein rab-19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ76"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="217" mass="25005" checksum="3C05B47E52FF713C" modified="2023-09-13" version="1">MSFDFNFKVVLIGSPRVGKTSLIIKYIDAIFKPFRTTTVGVDFKFKDLEIDNKGVRLEIWDTAGEEQYRNPLTSSIYKNADTAIIVFDLTVEGTLKEVDYYIKEIDDNCRIDPLIVIVGNKCDLIEKEIENIEEKIKEISQGKEFKLFKVSAKDGINVNELFEFIAKELKEKKELNKHLHHKKINTGLDQNENNLNQSKVIKNSDLIQIKQKKQGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQS7</accession>
    <name>A0A9Q0LQS7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQS7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="878" mass="101077" checksum="7398D324CFFD49D1" modified="2023-09-13" version="1">MQKENFPNSKPIQLYSMKPQSLDQEKRQEEKYSRKKREQTIGQKLKMVKNAFRKIEENNIIWEVKQAQKQQRTLFWSETNIIGFSTKSGLSAKTTPFLEYPVYIFEANHPWKHQPFVTPHKGPIEFVVFQENSVPRFLTCDASFGLCLWQTPSSLIDRFKITHKFKVHNIVSVAWFYLPKGENANARENTKENTKTGPQTHFFYPAFLTLSKMGRITIYFEMKGVATYCPFFADIHNDFSYITNAVMISDVIVALGTQVVIIATVEEVSPTNLNIYSCHPEFEIFKQTGRKYFPSEFAIKLVRISPENYEKTIKIVVVLTLANSQSMDKDDDLQHSNDDSDPQGYRSILLVFVMHLNRYKQNMREMRLQDKQEQNSNPNEDPTKKNPHTQAQQTQPQIPSGTTSGQGQEMRANQRLFKQGFACEKKFQMHFKEEISTLHFSKKGRMIALTAKSGKLFLLDAIKFTQIASFETTPADELEKGETPAAPISACFSPNSHAIAVLLENHKLRVFLVPNRPVFSIQEHQQTQTKENETEMLMKQLKIDIVKALINRYSVFDIVARLQLEDKVQVDSIILNLEQEIIRKKGIPSQLYLLFLQPFFSVFDNPRIYISFIIFFAIQFSLEILVSKKNTRLFGPIMRATSDIILFIMRAILVPYDPFGLNDLKQPLDVSHFQSDSSKKFSLISVSDFLCDNLGFRWDFFPYLNQLFDILFNQDFYTILLQSHQSIKGFEDKFSSRFKSLYADFFHFISSKETQTVGDTAQMLISSDLPLSSVLSNITSTMLASLSSLLGFNHSVLNNFGYLKRKQNQIQQDRHESDSEEDSIVSSLSSFLSFSSSYFSSSPLKQCVHCGRLSDLNSEDIKFCDCGGLWNTYVSSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQZ0</accession>
    <name>A0A9Q0LQZ0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch motif family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQZ0"/>
    <dbReference type="OMA" id="GWFNDLF"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="39146" checksum="2ABCE2D26E91701B" modified="2023-09-13" version="1">METVNSITEEKPMEVAKSGIFFDSDQHKIYIFGGNKLNPTQESNQLFSFDLQNNKWEQIKPDQNKQPSIRSAHSMTGFKNKIWIFGGNMENEYYDDLWEFDTNLNQWTKIEFAGHEKKPSGRYSHSAIYHNGFIYLFGGFSNEGSRKNDLWRFNTLQKKWEEIPSIGEIPKARSSHTCHIYEDNLMIVGGLDESKIENCEIYLFNLNTFEWSKIHPIFDLPAFGGHVSVIYENQYVVCFGGFSWRDRYSNKLRYFDLKKKEWFLYDFPQNPSLFPSARFGSVGCAYSRSHFFLFGGQYENTLTYDEIWDFGFEQEIICDLRDFLDQKLLTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR04</accession>
    <name>A0A9Q0LR04_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">mRNA decay activator protein zfp36l1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR04"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="178" mass="20788" checksum="7D7D14C1D4D5AC3C" modified="2023-09-13" version="1">MGSLAANSNQTINFLLNHSIKSNNFKNPKRFVNKIKTIESKKNGNEVLSKKSLKKKITKKKEYQEQNLSYSKNQLSPSLYKTELCRSWEETGFCKYGGKCQFAHGEHELRNIARHPKYKTQVCKSFHKDGFCCYGKRCRFIHDKIESTTNPTQFELFSLEPKAEEEPPKRLNIFRLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR23</accession>
    <name>A0A9Q0LR23_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR23"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="364" mass="44150" checksum="62A99F4803724DA1" modified="2023-09-13" version="1">MKDLPKISQIFQEIFKFIGKEKETEEERNFIKQLDDLFSEFINNNNNIQFTFSIFSKEQIFSIIKESQFKNKNNNSLSLLKSFKPNLKNEEFENFKTQISQIKIDSNFFKTFINELEKLIPIKNSIKQRIIKIDENILKKSNSQFNQIFDNQNQNQNQKFFFYKLEKEKEIYEIVTSLYLGYSNHFPLKENILFCDSNSTKNDINNFFNIYQIYNEKYENIPKNKYLFSILHSHKLSQECLKKIGNFRIVNQFPKCLITNKIKIISKKKITQIYQKYHKLYPKIQLFTSKISGMGKTYQIHKKFNEEYQKENYLYFNIILSKEISNDFIKDKEKEKKFFILNYLFHLVLETFRFYLGIYNVEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR78</accession>
    <name>A0A9Q0LR78_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha-centractin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_06632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR78"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="377"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="11">
        <location>
            <begin position="488"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="681"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="751"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5075770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="846" mass="97952" checksum="2065A9417613F907" modified="2023-09-13" version="1">MVDTVIATQTVVIDNGSGMIKAGLAGDETPKCLFPSFIGKIKNRKVMAGGLDGELFVGSKAEELRGLLKLKYPIEHGIVQDWSEMERIWNFIYSELRVQSEEHPILLTEAPLNPRKNREKSCRNIFETFGVPAFYVAQQAVLSLYASGRTTGVVLDSGDGVTQTVPIYEGFAIPHAISRIDIAGRDVTKYLQLLLRKSGNIFTTTAEFEIVKNIKEQTCQVMETIPTGEFDTIVKSSQILYRLPDGNDIQIGNERIQAPEILFNPEIIGSEFDSLPQILFNSIHQVDIDLRSRLYENIVLSGGSTLFPGFGNRLLNEIKTKAPKDIKIRISAPPERKFSTWIGGSILASLATFKKMWISMHEYDDGGAAITYNPIGLPLKYGFLAKQSGNHKRWKKRFFILKDEYLYYFKSRVDEIPCFEISLKNAEIKNDPNPKNTTIFMIFPESKEQETKEKSFLSLSAKTQEEKENWINSIEKEIRKASRKVIGSLINDVIKLRNDGKLIPEIIEKIIEFLKTNENENKILETEGLFTKSFPEEIKELITDLNRLKSIQLESIKNPHLIIELLITYFKELPVPLLTNEFYDEFKEELSNDKKELIQRFIDFFDKLSFPVYETLKYLIEFLEYITLKTNRFTVEFISKIFSKILFSQENKTEKEQEFQDRLIEFFIQEFGEIFVCHNNSELKFVRAIHNYVPQGWKQLSLEEGEIIQLIRTHSSGWWVGKLKGNVGLFPFNYTQFLTEDEKKEENQNFNQKSDYELNKLTEQNESTELELCIEQAQESNEKLEEIADYYHKHKQDISKENLIQILSFLTNEVKTLEKQLEKETMERTKLQEKLLRLTNEQLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT19</accession>
    <name>A0A9Q0LT19_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT19"/>
    <dbReference type="OMA" id="NEMQVAN"/>
    <dbReference type="OrthoDB" id="10249208at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="360" mass="40388" checksum="C0900FEC17A0A8AE" modified="2023-09-13" version="1">MCKAGFAGDDAPRAVFPSIVGRPRHLGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGMVVDTGDGVSHTVPIYEGYALPHAIMRIDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFDQEMDVAAESSSIEKNYELPDGQVITIGNERFRCPEVLFQPSFIGMEQPGVHETTYNSIMKCDVDIRKDLYGNVVLSGGTSMFPGISDRLQKEITQLAPPAMKVKIIAPPERKYSVWIGGSILASLSTFQNMWISKEEYEESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT73</accession>
    <name>A0A9Q0LT73_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000032">
        <property type="protein sequence ID" value="KAJ5079476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT73"/>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057852">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057854">
        <property type="entry name" value="TPR_WDR11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23751">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23752">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23753">
        <property type="entry name" value="TPR_WDR11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR11 first beta-propeller" evidence="3">
        <location>
            <begin position="15"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="4">
        <location>
            <begin position="402"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 TPR" evidence="5">
        <location>
            <begin position="855"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="807"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1221" mass="142940" checksum="6E96621A01F93244" modified="2023-09-13" version="1">MNQILYSIIPGTITKINENAINWGLQGLIAFGSHSAIVIFDPVSFSILQVLDGHDSEVVCVQWSPLLNENDLENPYHSILASGDVLGQLIIWDPINAKIITKLPDIKKRKQRRKILEIKWIEQNKNYLLTLQTPSIITLWNINLNSTNSEIIEIWQLDLEKTNDIHESCLFFELNTSQNYSMIIGSDTGNLFFTNEFKIHKKRPPKILRKIKTESHETTKFFSEEIYTPSPQDLTIKQIQFDPFQKDILYIVYARDITILDLRINMAISRIILNEARSSFIQLVLTKAQNHLFCFHEDGSLSIWVQRVTNKVIKYEPITFCEQLRIIKKKNDGFIISKLVASPFKPNNFIFVSENEIWKLTYKTKRKRMQKKEYEPKILLTGLFELINSPITCMSVSEYNRNLIGIGTEKGNIQIFSLEKFLIKSSFFILNSPIRGLKWISEDKIICFGYKMEENSYKNQIFILDIQSGFLKEIQIKLAENDFIRKIKLSPKQRYLAILYNNLKPEIWDLLFSEKFEPIYKKKISDFLWKANERSDKETFVFATRKEATGFLCSIEDQTLSPISNISFPKSMTKTSCIDWNRLVLIFGNYSGNLYCAFIKPEFKTTIIQVGVTRIDQIKLSPNPNSFLLLVLFIDGEMSIINLKNYQKITSNTSKLQFKYRITNADWISETKIVAMCSDGFLRIFDDKLICQNTIININNFTKKPQAPYLFPYKTTLSLKTAFQYGLKIIENSNEIEDEEIFYIIKDDENEVNKQLIEINSSISNKTKKGISKCDNIPELCIFTSLFFGDQKEERFWKLVLHYLQFFSNNQELLKEIENQIENQNKNENQKENQNQNQNINQNQNQNQNQKENENEKENEKENIIEHYDDDDETEIQKQILEDEYFSKPKKERLFSLSRNFGLFQETEKLKQDRLQTADFHQTFRGNLYPLGKIIIDDYNLLNQHSKSLPILMETQMKNPSFFRDMMFAIAISSQISKDQTIQTIKQIGSNLILNGNHHDGAELLCCSGLHEEACNLLQNIGKWTYSCRIAKFHLPFEKSKLIFQKYANHLLVQKNQEKAIEIFLMIGDFHSVLQFLVELKKFDLAYLFYLSCKKFGFLTKIEEENLKENLKENLKENENENLKENENENENENENLKENENQNQNENQNQNDSISLKDFIQKPFSLIPLNDLILKSKIEYGNFVFQLGLINFAKNIWINCGERGKELIGKNFPKKEEKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTD9</accession>
    <name>A0A9Q0LTD9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTD9"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="464"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="562" mass="65831" checksum="415DF46CA5CD47DE" modified="2023-09-13" version="1">MNEILFFGQNEYPKLFKNKPKRIIKPIQFKFENENENENEKQIKQISTSFDSTIFLFKNGKAIEYSNQNDLKQNPEKIRIEENIQKVSVGEQNEAILTYERNVFAKGYDINSNNSNEFINISSLIEDKNDRIIQDIASGWDSIYLLTSNQNAYGIGSNDYSQLGLDSKTLQKTEKPILMMKNVSKIFSGNSSYHVFLLNSNQELFGCGYNQYGQLGLGESRKKETRIQKLTKIQNIPKGKIIDIKSGEAYSLMLIENEDENENPKRKLYSCGNSGLNGLGKNKHTYEFTEIKSSLFENDNILDFSCGRYHTLIFTFKGKLICFGYNDYGELGTGDTENQSVPIQIELPKLRFNEDISNYHVSYLIKLFRRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIDELETGIDYFQLNQTNPNLFDLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTH1</accession>
    <name>A0A9Q0LTH1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTH1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="274" mass="32780" checksum="F0E1BD6CEAAECF76" modified="2023-09-13" version="1">MEMEMEMLNLLDQITSSKPLHSKIAFQKLLSFLSQNDFDSKIHLITQKISCLIQEPIFSTKYLTKLFEKILEKDIKNKKYIQWLINDVSKSRNENAKNCLISLLKNDKKSIFVDNLDFSSLETVNIEEIIGKFIRNFLKSMQKDSSHKNLIEIIDKIESEKPNIFDHLQNPNSFLVFQFLFIKQKQDENNYIFLQNLILELFKRKYIDFWALNFLDSTLFLQIKNFQIKTQFDHQKSNEKIENQKIFSKIYDMQNLEKKKIDKTKKRKQSNDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU95</accession>
    <name>A0A9Q0LU95_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Abc-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU95"/>
    <dbReference type="OMA" id="DQPMKPA"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="9"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="680" mass="76475" checksum="89A6CD07D9AF6FD8" modified="2023-09-13" version="1">MSEITKIPIFVRDFSFNVKTKKGYKTILDHINLSIPSGSLVAIIGASGAGKTTLLNSIAGRVSGKSEGSILFGNEPHSNRINKILSYVTQQDTMHTNLTPRQILRFVSDLRLPKTIKKQEKNQIVENILKSLQIEHCANTIVGSPESGIKRGISGGEMKRVNIGMGLVTNPSVILVDEPTSGLDAQTAYLCTSILKDLTKDGRTIISTIHQPRQSIFELFDYLVLLSHGKLVYFGPINEIENYFAKMNFFPPRNTNLADWLIDLVSLSEGELKKEETINKLSKELSVYQKDEIQLDIIHDKNEIDLNEIDLNEIDKDKEDDLEIQDIPDDFEEIDLDKITNPNFIQNNSNGIIKGEVGTLEFIKSLVKYYNNSNLMKKTLSMKIPKQRMDLHLERPVNLFRKTLILTKRGFYGLRNQKRYVLQRLLEPAISACIVAWVFSAISNNQSGISDKIGLLFFIGLSQMMIPIISVLFVLPKEKAVFLRESMDSAYPTVCFFISKVLTDLPFEILVPTIFAVIITPITGLQTNPKHWLILILFCILSANAGSAFGLMISTGTRTPEAALLIAPSMLIPMVIFCGFVINLDNITKALSWIKYIDPLKYSFASIVKNEFTGLKFTCTQSELVQGVCPITTGEQFLKLKGFYNVNYWENALFIIAFILLSWGLSVYFLSKARKREAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUL8</accession>
    <name>A0A9Q0LUL8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUL8"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040459652" description="protein disulfide-isomerase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="469" mass="56125" checksum="1C1DEB4F00FD706A" modified="2023-09-13" version="1">MKYFFLILILIFLIFFLQFSFCQEYANKETNQNENENQNENQNQNQNQNEQTKPQPIIALTGEDLEKFIQSYEVASIIFFSPYQKDIEKFQETIFRAAYLLQNISKVKFGVINCYEFDYYCDDYTESFPTIKTYKNGKFYQDFEQQINISELVFYFTKVDFPLIYRIESFQEMVEFQQNLTFSGIFLFDNEPDEEKPSLYIFSQKEISSMKDSGFPFGIFVFDQDENDEFFRSLKKLAKSFQSKMKFFYLQNDHLEFNYFTEFFQISKLPSFTIFSSNLLEFYRMDSEFSINSLTSFINDFFQGNLETTTKSEPILESNEEPIKKVVYSNWNEMINLNEKDIILFVYTSLNNFSESKEFDHIYQILQEFAQKIQENENLIVAKIDGLRNTILDSKINHQIPAIWLLKKNDKSNPILYQKIDLTVKSLTEFYLENVEGKSNQKKKKINRNKNQKRLKKKPKKNDQEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW25</accession>
    <name>A0A9Q0LW25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000021">
        <property type="protein sequence ID" value="KAJ5079927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW25"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF366">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="272"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="425"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="658" mass="76526" checksum="757E7E3D123C3599" modified="2023-09-13" version="1">MNPNQDRSKSQIIFGKTTVEDDLFEENVDDSGYDENIESSTDSEQEKMPEFSPKTSTLLLSGYSPKSSGRNIHEAIANKTYGKLKKTVTHEVIENIFKKTDIQEVTDLPKTEWINHAMRRNPAVLEMKERSRFFSKLESFSILSQTAKTENPTLLSKSQTLQMILEYLSLLGFKKTVLSICQESGINYQLPYLKNNYLEKMLILGAPSIEDFFQIVSGINIPQNEPQTKGEDIEVEINEFMIGNDQKTDDKSIWEEGEDSDENILFLDPNDKQSQIRAATLNKLVEKLTDPEQYNEKFLNYFLLTYQSFTTTHFFLKKLIERYHVPSHFDPNFRRLVQMRVIIVLKNWIENYFADFDQKSLHEISLFIDNSLARDKHIDLAKGLRNLVFKKLSGNQSSKLIRVELEPPLIPRNLFSPKLSLDDIKKQEIAKQLTLIEFEIFSKIESKELLNQAWNKPKLKYRSPNVLKLIDRFNELSIWIAQTVITTESTKERVRTITKFIKIADHLLRMKNYNTMMAVIAGLNNSAIYRLTETWKLVPEKRTASFKEFLDLMASTGSYKKYRTTLQSSTPPCLPYLGIVLTDLTFTEDGNPDFIQNLINFQKRRLVCEKILEIQNFQLIPYGFQPVHQIMSLLRGFPKLWTEDAMYSKSLEIQPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWU6</accession>
    <name>A0A9Q0LWU6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWU6"/>
    <dbReference type="OrthoDB" id="2441258at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="167" mass="19683" checksum="B46584FB3C96C32B" modified="2023-09-13" version="1">MKKGFSAKRDGFSSQNWHLKVDNKGKTLVIIKTKDNFIFGGFSQVGWTTDKSKWNEENRKYYFGSIIDPNAFIFSLRNDKSHRKPEKIIIKHPKNAIYYDYLYNGPFFGIRVYPDLALDHHLKSGYSNLGYSYYLPNRIEWNTNEAKSYLAGSYDSWEVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXE9</accession>
    <name>A0A9Q0LXE9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXE9"/>
    <dbReference type="OMA" id="FEQTYKR"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="515"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="590" mass="70377" checksum="ABBC5DEA4FC4290D" modified="2023-09-13" version="1">MASPKYQLKSKYPGLQNRTSRIIRNPKRRSISFFGGIPQKNEEDSKENLDKIRNTLDQLKSTNKMKEENQNEIENQDENVENEKIRIDELEQLLKQKENDLILAAEIGQSLIEKNLALQTTLEEISNIYDIEMEKAENQEKILDELTQSLKELEEEKKKVEHEFAKLKKEKTALEEHYSKVMDDCRKAEQDIEILQKEQVNSLKKLDDKKNEEKREMQLHFTEKIANLEQENEKIKKQISEISDLKQNLSKFRQQIEEFEEDNTILSRKNEESNIELSRLQKEYQKLKSNSVPLDEFNNTNNQLKEALSKIQIFEFNEMSHQTRAKSDADLISSQRAEIESLHQIINEKKTQEIQSRSLFDEMNEFPNEKRNQNQFKQVEQNQFKKVEQNQNQFKKVEQNQNQNKNLNQNQNQFKQMKQNQNQNQNQFQNQFKQMEQNQNQNQNQNQFKQMEQNQNQNQNQNQFKQMKQNQNKNQNQNLNQNQNQNQNQNQNQIQNQIQNQFQNKNQNQNQFKQMEQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSNSKSIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXM7</accession>
    <name>A0A9Q0LXM7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXM7"/>
    <dbReference type="OMA" id="NQIKWCR"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="445" mass="51281" checksum="F18146641AA2A22D" modified="2023-09-13" version="1">MSFGWKVTQVFGDNSSPGPVNDCDIISALEFDTTGEYIAVGDRGGRVVLFQRESPPKYTDEIETNNSRLRGFKFYNEFQSHESEFDYLKSNEIEEKINSIKWLKPRNNANFLLSTNDKTIKLWKIYEKDTFIDNESALNFQEISSPSFLRIPKISKQKPTPSIHLRRVYSHAHVYDINSISVNPDQETFLSSDGLRINLWNLELTKNAFNIVDMKPEDLEDLTEVITDAKFHPNNCGLFCYSTSKGVIRLGDLRVSKTSTDSSKIFHYEDNESNSFFSEVINSISDIQFSFDGRYVVSRDFMSLKVWDLNMESKPVAIFHVHEFLTPKFGYLYENDYIIDKFECSFSHDGEHLITGSYGNHFYIIDWKREKAILVNASQNPHLNQQYFDAITPTNKNSPTTSALEYNIQKVDYSRKVLAVGWNPKEPIITFGATNILYLYAGKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXM9</accession>
    <name>A0A9Q0LXM9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXM9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="379" mass="43383" checksum="8D5D0D7A814383AF" modified="2023-09-13" version="1">MFDPDEIQAIVLDNGSFEIRTGFAGDDEPRIVTSSVIGEKLNQYDSYNSSSTSSKTEYIGNEAQTNREILNLNYPIQRGIIEDWDNMEKIWNDIFANQIKINPNQHPILMINPPFNPKSHREKTIQIMFETFDIPAFYIANSGKLSLYSSGRGSGIIVDIGHGVTHTQPIYEGYEIPNAIDRYDISGFDLTNFLIKLLEERGYSFTTSNEIEMAREIKEKLCYCSINYEEEIKQNQNQFNLEKEYELKNGDIISISEERIKCCEGLFQPRLMGIDLEGIHKIIYNSIMECDVDARRDFIGNIILSGGSTFFPNFTDRLLNELKALFPQQARVKLVVPPERKYSPWIGGSILASLSTFHGMWISKEEYDEVGPNIIDQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXT0</accession>
    <name>A0A9Q0LXT0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein rab-5c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000008">
        <property type="protein sequence ID" value="KAJ5080554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXT0"/>
    <dbReference type="OMA" id="RKWITEL"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="230" mass="27085" checksum="87528EB972352131" modified="2023-09-13" version="1">MNTQIFKVVFLGDTTVGKSSICLAIFSNVISLDTQSTIGASFLTKTYEIDQIQVKLELWDTAGVERYRVLAPMYYRGSKAIVLVYDITKKQTFENLRKWITELKSTFSEDFSPEFLLIGNKLDFEENREVTKKEGFAFAKEYSMMFEETSIKEMDNLKTMMQNFARKLIYNNWNTMCLYVKEKSVEKISEYIKNGYDVNKTNLFVIHLEYFLFQKNSQEEQQKKLIHQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYC1</accession>
    <name>A0A9Q0LYC1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00722</name>
        <name evidence="2" type="ORF">M0811_14451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000028">
        <property type="protein sequence ID" value="KAJ5079535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYC1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="182" mass="21439" checksum="4B28AD060482BCFE" modified="2023-09-13" version="1">MNSKLIFNSRIFRLKSFVEETGKKYYRCMTPNCGATLIRFNNQYRLNRPHSEECEKQIQGNESLSKRFWEFINQMASELGKTSMEIYQLAVERINSEIGEDDHFEIPPAHHVLQTISTIRKARFPFELIRILSESPYSQTKNEKKFWRFSSEVLIQDKKEMAVCWFSDSVASSLFPGQSDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZH4</accession>
    <name>A0A9Q0LZH4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZH4"/>
    <dbReference type="OrthoDB" id="297375at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="236"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="345" mass="40927" checksum="658873AF6BB4F767" modified="2023-09-13" version="1">MLIENENENENPKRKLYLCGYSKYNGLGKNEDTYEFTEIKSSLFENDDNILDFSCGNGHTLILTSNSKLLGFGYNYFGQLGTGDTKDQSIPIQIELPKLRFNENIYNYHISCGYHKSFIYYSPLSFSNLEEDLIKLFKRKEFCDISFKTKNGEIIKAHKLILKYRLNQNEIEKLKEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNQIKEEIEITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQNQNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4G0</accession>
    <name>A0A9Q0R4G0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4G0"/>
    <dbReference type="OrthoDB" id="270855at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10032">
        <property type="entry name" value="UDG-F6_HDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026353">
        <property type="entry name" value="Hypoxan-DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04274">
        <property type="entry name" value="hypoxanDNAglyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="36506" checksum="B9EB9387E0D14124" modified="2023-09-13" version="1">MTEKKIVDDETHPFQPLVDDNSKVLILGTFPSIKSFKNNLYYGHPQNVFWPILQKIFEPKRKTKMSNSERKKLALENGIAIWDVIKSCERENKSSLDSSLTTKEPNDIRNLLKNHPKIKAIFFTSKNAQNLFKKHVGNINGYTYKVLPSPSPAYAAMTFEQKLEGFRRAFKSIGLIGENKNDKKKKTTLESFGISKKESNQKSNELKEESKELKEESNQKSNQKSNELKEELKEELKEESKEESNQKSNQKSNQKKKKKRKEKEKKKKPRKNRKKRIVNDSENSSENEKIKKRKKERKKKTKKTKTKTTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4I3</accession>
    <name>A0A9Q0R4I3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4I3"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10254" checksum="C8F8CB9D6FE907C0" modified="2023-09-13" version="1">MRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKKGIKITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4S8</accession>
    <name>A0A9Q0R4S8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_03599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4S8"/>
    <dbReference type="OMA" id="AMEFSAE"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 7" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="29"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="218"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="9">
        <location>
            <begin position="505"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5066266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="741" mass="84778" checksum="22C49CECFCF2908E" modified="2023-09-13" version="1">MFSCENIKEFLGESLEQNQIQEKPSCMIIIFGASGDLTNRKVIPGIHSLNCESRIGTNTQIIGVARTKMTNEEFRDSLEESVKNYSRLKPGKTTYCEPWDSFAKKITYLYGDYDDPKTYQNLVQHLLDLNQKFKTPLNYLFYCATPPQLYPIILRHLAQFKLNQNRDSFWSRIIIEKPFGSNLETAIELHKVVNSIFTHSQVFYIDHYLGKETVQSILTFRFANTIFEPIWNRNYIESVHVNVMESVDVGGRGNYYDKSGVIRDMLVNHLLQLLCLIAMEPPPRYTSDYLRREKIKLLQSIKPISCSNFAIGQYHGYRSEQKISKDSNTPTYADVDLEIDNWRWQGVRFRLSSGKKLAKKETEIVLTFKQPPFSMFSTSLESVCKNQLRIVIQPDERIELKMLSKIPGAGMKTQPMKLTYLYSQGEPLPDAYERLLLDVMLGDSSLFTSAEEQRLSWKLFDSITDHGIPIQYVSTLGTNSLSSLVSQVNYLLPRKTDDIRVLVPEDVAKMYATMVATTARQFIQKKGIFTMALSGGASPVKPYELVAQEPDLDWSKIHVFLVDERCVPPDDKDSNYHMINETLLSKVKIPPENIHRIHTEFEPEKAAQLYEEEIEKFFGNQKSIKNSTFFDLLLLGMGDDGHTASLFPGANTISETKRKVVATFVEQLGVWRVTITPIVIQNSLNASFFVTGTKKSKRLYTVLHGPQNPFLIPAQLVRPKGSLSWFVDTDAYSSNDICFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4U3</accession>
    <name>A0A9Q0R4U3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_03644</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4U3"/>
    <dbReference type="OMA" id="REHRIIF"/>
    <dbReference type="OrthoDB" id="17726at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="13">
        <location>
            <begin position="253"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5066311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="460" mass="52259" checksum="061901A577C27156" modified="2023-09-13" version="1">MSESSEIELSEKKEIKEEDKSEDKSEDKKQEHKHKYKHKHKHKHKKDKKEKQDKQDIEMGSDSENKNTGQMTRKRSGFGTWKQTFRGTLGFLPKEEQKEHDKQWQNFSTFRRKARPLLEHQETLQLHFDPNQTGPENAQNIDGEWQPTFVSSDDEPVDGGTKTNPDDPNKFTPKEKAKARAKAQAQAKLYEEPQKEHKPYFIWIVSLVDVVMMIVALVKNHGFESFQLNPWGGPSQQTLVDLGAKDGPKIKDGQWWRFITPIFLHVGIIHLLLNLSFQWRGGKQIEQSVGTIRVAIIYMLAGIGGNLLSVVFLPNLVQVGASGALFGLLAVLLCDLLQNWKQIYEPKSSLIKMIVVIILSFGLGLLPAVDNFAHIGGFVVGLLSGIILMPYINFGKTRKILVLIAIPLLIAYYVILFAVFYRDIEGDAWCSFCKYANCIPVKGWCDNLDGTEVKKTDIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4V4</accession>
    <name>A0A9Q0R4V4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sh3 multiple domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4V4"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016176">
        <property type="term" value="F:superoxide-generating NADPH oxidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF20">
        <property type="entry name" value="NEUTROPHIL CYTOSOL FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="261"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="386"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="443"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="561"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="642" mass="75094" checksum="458371CC4AEFF2FA" modified="2023-09-13" version="1">MEEKIENFEKNRSKNMEIIKLIRETKSALEKKERNHRETEKLQALYSSNKVTISQKREFENLLKEQKKEIDQLERSIEELKDLGKKLVCEVKAREPYSARNMGEIDVKENDRLILRKVEKSNAYVHNTSSLQKGFIPFSHLLVVKFPQISIENAQKDLLRIRSLLGNLIPSVSSQKKRGMVLFDFEAVSSEQINLKIDEIVEVENYDQDNYLVHKSGGKNGIAPKGYIDIMDSQDSLLTDEISSEESDEDIECVDFLEQKNPTSSLISLYDFEAVQEDELSIKPGQPLLLISRDDDWTLVKNNIGRQGFVPSTHVQEIEEELFFQLQAICQHNLDQKAQVVADYRALESNELSLNEGIIVKVNEQNPDGWWLVEYDGKKKENNKEIENEYGIVAFDYEAKDKDEISMEKGKKIKILERNNSGWFLISDGKKSGFFPGTFIDMINNSNEIQNQIQNENQNQKENQNKINYSNQNQINSNQNKKENQNQNQNQNKINYSNQNENQNEKKKFFERNSNQRISHKLIPKENSPYRQFEKRTKLNEIKPQISNSPKENLTKTNKIQEIKNQNNSQQENEILKKENENLKKKLFQSEKKIEDLNKENLSLRKLITDLETKVENEEKLLQTIRQLQAEKAYYEKIVFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5N4</accession>
    <name>A0A9Q0R5N4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5N4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="112" mass="13393" checksum="0D47A71D29A327EB" modified="2023-09-13" version="1">MGLKIELRNWKEFLEKFNFPSLEKWPQRAITHLDYFFTNYIVITIFFVIIVSLQDPICLLTPIPVIFIISTLYFLEKENVFKFENSKIRILIYCLAIILISGFFLLIVAEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R679</accession>
    <name>A0A9Q0R679_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein mlh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R679"/>
    <dbReference type="OMA" id="ANYHVKK"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="227"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="822" mass="94489" checksum="7BC4FF5FE4AF0C4B" modified="2023-09-13" version="1">MTTSQIQTTPKIQKLTQEVINRIAAGEVIQRPSSAIKELLENSLDAKSTSITIQIKEGGLKQIRIIDNGHGIKVEDLPLLCERFTTSKLRSFEDLQQISTFGFRGEALASISHVAHISIITKTPDSSCAYKACYADGALSPCGRDGNKDPQPCAGTNGTQINVEDLFYNVLTRKRAFGNANKEFRRIVDVVSKYSILNNHVSFTCKRHDQKSPTLHTSQTTNRTNTIQNIYGANLASQLITFSFENTDYPHSVEAIISNTIYSMKKFLFILFINNRLVDNVSLKKAVESAYSAYLQRGVHPFVFLSIKIPPNNLDVNIHPTKKEVRFLHEEKIIESIQEQIMKKLQESSSSKTFITTSQLSSTKLSSQILIISDKSQTKKTPVKSIIEKNSSLPFEKVKKNLNENENENENQIKNTNNENNENNENTKKGAYQYQRVRVDDTDQTLDKFILSERIHNKENNNKENKNNENKNNENNNENNNMEIESIDLLVESQNSESITKNSTNSTISDLSISVDEKDKDKKKKDKKKKDKKKDKKKDKKKKEENSQISSNKTFLKKRRKWRDVQLTSIKTLRQEIEDNKHEIISDIFNHHVFVGLIDTRHALIQYQTKLYLVDVFLTTRELFYQNILKKFSNFSIIKFEKALSLKELIFIALNSNFSGWSSEDGDKNEFADSVVDIFLSRRLMLLDYFSIEVSQEGNLCSLPLLINDYIPNFSFLPVLILRLGTEVDWSEEFNCLKMISHELAEFYAFKNIPNFENQNQIQNQIQNQNQSDKILSQKEIIQSLVFPTFKKGFVAPQWFMTESVIVEIASLEKLYKIFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6N9</accession>
    <name>A0A9Q0R6N9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ada2a-containing complex component 3 isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6N9"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="97"/>
            <end position="129"/>
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    </feature>
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    </feature>
    <feature type="repeat" description="ANK" evidence="1">
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        </location>
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        </location>
    </feature>
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        </location>
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    </feature>
    <feature type="repeat" description="ANK" evidence="1">
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        <location>
            <begin position="804"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="837"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="871"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1223" mass="139626" checksum="763BB21C686E176C" modified="2023-09-13" version="1">MNIWQIIEQNNIELLKKIDFISEKELEKNEKPILNFAIEKKVSKEMIELLISKGTNENQVDKKGMNALHIAVMNKLGIETLNFLISQNINIYAKDKKGKGILNLAFQYSSLEVIEFLIEKGLDLNEKTFGSSLLRKNQLTNLHLACQNNSLEVIEFLIQKGLDLKAKTIKNQTALHFACQNNSIEVIEFLIEKGLDLNEVMERNQTNLHLACGNNSIEVIEFLIEKGLDLKAKTFRNQTALHFACQNNSIEVIEFLIQKGLDLKAKTHQNQTALHFACKNNSIEVIEFLIKKGLDVNEKTNQNQTALHFACKNNSIEVIEFLIKKGLDVNEKTNQNRTALHLACGNNSNEVMRYLIEMGADVNAKTIWNESILHFGSQNTSLDMIKFLISKGCDFNEKTSYNETILHFACESKSTPEIVEFLIENQLDINTKSTYGETALHIACETNPSFEIIRLLVENGIDVHATTRANETALHFVCQYHSLEVVKFLIEKGLDIHAKTANDETILHRACRNNSLEVVKYLVESGVDIQAKTSENETALFSACQNISSLEIMRYLIGKGLDINAKNHGNETVLHYAFHNNSLEFVKYLVESGVDIQAKTSQNQTALHLASWENVSLEIIKYFVEKGLDIHEKTIRNETVLHLTCDNYPSLDAVKYLIESGVDVNAQTNINYTALHFVCQNSSPFEIVEYLVENGADVNAKTIHDQTILHYACQSASFRITKYLIEKGADINAKTNRNYTTLHFACQNKSLKTIQYLIENGIDINSRTNSNQTPLHSAFENSRKPKIVEYLIAKGADINAKTNNNSTILHFACQRRSTEFIRYLIEKGADVNAKTNQDETVLHLACLRGLPFDVIKYFVEKGVDINAKTTRDETALHFACRKSQSQTIQYLIEKGADIHAKTNQNQSALFFACYMNSSLEIIKYFIDNGADVDGLTHENSSPLSSSIRNGNGILIRLLLMSGATTSNLKEDQISKQFIQLFSQVYSFNQDLSNLLKSNGVFSDYQIQSIDSSRFKVHKLILLTRFDNNESILQKFVDICHEKSKTEVENAINFLYTGFVNFEEMYEQIVSKQNKTEENQKEEINPIPEFFKEIGFDSNWINQKKGIKGIIKDFGKLYERNETKDFTIIVEEKEIKVHKIILILRSELFKGMFQLNVQDSSNQVHDYSRKSFETIQELIYFLYHDKFSKEIKKEIIEEFLDLKDFYQLNPNSIIDLILRESNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6Q2</accession>
    <name>A0A9Q0R6Q2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5069234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6Q2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="92" mass="11250" checksum="0C0FACF3D84B83DE" modified="2023-09-13" version="1">MYSILFNFILFVHNKEDISINQELEKEVKQLTDSLINERNHKKNNNSISQYLLKITKKNYHTFQNLFFIEDDNFYEFLENNNNNNNEKKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6Y8</accession>
    <name>A0A9Q0R6Y8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Duf914-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
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            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="417"/>
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            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
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            <begin position="78"/>
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            <begin position="239"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="263"/>
            <end position="281"/>
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    </feature>
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        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="417" mass="48074" checksum="1D8A1F6FB9CF3161" modified="2023-09-13" version="1">MFLFHLILTFFLHVMNGVYATILAWVQSPNHGKMGTFTLLASSNFIGLIFYVSLQLFHVRKEPNKISKLFIFYHLKGYPRSAWILTFFTAIVWVLANFSTVYSFRYASHPSVIQGLSLLMPFMVFFISKVFKISKKLPRFIIPAFFISVGGCLMMILGVNKSQDNNQVPNTNNTAAITLAILFDIFAAFFFSFQQKICRTYKIRAEVLLILIKQMYIPSTLALSFILKEDWGVFKNLGVEGWMFMLYITIGIMCLSRLGQTKMVIEIGAALYSSVQAVRLPSTMISDYFVLKANPHWPLQYIGAIISFITISLFLGYQAYLERKTKKNNKNKRAVFDPSTSSFIEETEEEIAMTNLLENEDPNFPNEDLDDEIDNNEMKKIEIKIEDVKEIEDEMEEIEENKTKTEEVKENQTQNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R767</accession>
    <name>A0A9Q0R767_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress response protein nst1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R767"/>
    <dbReference type="OrthoDB" id="10660560at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="439" mass="52534" checksum="0C1304D090F16E74" modified="2023-09-13" version="1">MEQTEHGKETFEKLKQIHIPDIRFKKEKMEEFKEWILLIQKKWKKNKLKQKMLYKMSSLYEEIMKIEIQVEKSKKKITGLEKNQSKKMNEEKANRLKELLSKSRIEYENNQKKLEEIHEKSKEKTEFDLISQNKIDFEEKIGLTQLANEISDIKSSLGVSRSNRGDEFEKEVKNLIEEKILSQYISKLDQDDINNGSSLKLLSNVSLGAARGEIDYLVAQIKKNPQFKPPKKPNQTISKQKLVKTAEFIVEKVHAIIEVKNNFDDFGYGFEKKQEMLHFLTDDFENPEDYKMFINKIYPKGRFTEDINVVHREKKKEKYLFTRKSFENMFPKEKEGYFIQNCFYITHIPKYSFGTKGQFSIMIASKIYSDFQFNLEDENYLNELFDFVTSFEMDPLIDKLQIYLKNPSWCQFIYLLKKKRKQESKENEQENEQEKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8Q7</accession>
    <name>A0A9Q0R8Q7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agenet domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8Q7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="891" mass="103354" checksum="45590E96D670B537" modified="2023-09-13" version="1">MQKEIPQLINKIKKNFSSNSFKIKVDFHFETNKKGFIEFLPHNLRIKSDLTQKHEALLINYNDIQIRKERFILLKLFSLKKIYHSLDEIVSSNFQIFGTILSENEELSAITTRFLSLGKCKFEALVYCEKIFRKCLVVFSRGNFSVITDDFPTLFCPYSGLTSVSEILSERNFIEITTKIGNIYIYSFSSSETSLLLHAFKEFQAHAPFQQIQNISQILPISYLSTELPKNINEILPETLINTPTQIINETYTQIREKVSDKLIMLYQQLSRKPNLDDPFKNRVSFSVQMLSSSFEPIFERTLLALSKDFLLITNVRFVFVVPLSHVKEFQLLERNSVARLVLKNKSMIFEFKNLEDFTTFELLFDYCCKNTNQSLKKGNEGKYMLTNFDTLVFGKSYLKIISFIQEKICYSDLQISSLDDIDICLVKLEAPTSIFFELFQTKEEKQFFLEKIEKKKSEVENCLDTKKKEEEKEKHLVNENEFEVLCLKSDFAIRSIFRFEPEKSDIVFQQKNEEYFHKFHSVIGLSRLSDSNNFNENFNENQNENENENLNENELQCKWILKLDLISKQYIFSMISEHDYHSFIGKIQYILSNLETNPEKIQKKSKSQQVMKKTKKKSSNYPQKAISFFNMKKPESNSKSLSKSESNLKSESNLKQNSNLKQNSNLKQNSNSKENSITSSTSKTSIVSGNEIKLESSDDSNSQEKSNSKSNPLSKSDSKLNSKSNSKSNSNSNSKSKSKSNSNSKSLSKSESNLKQNLKEKPIKGIDPPNPIKPIKIPNKNILNFQYQNGNLQLKQQSDNFSVKILSNNFKPITNAELVIEDNLVKLISKDQKTKYLFQTINLKVSKHPKKETVIRFSDSKNKSIIQFRNEEEKATFSQQLRQVKAQNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R924</accession>
    <name>A0A9Q0R924_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R924"/>
    <dbReference type="OrthoDB" id="3646030at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="416"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="515" mass="61520" checksum="88F6811867BB541D" modified="2023-09-13" version="1">MVLIFILKLLKGKIHYILLVKIKNQNSFEIIKYLISKKADVNAQTNKGEETPLHFAIQFQKNKENSFEIIKYLIENGADVNVKNKRKEIPLHFAIQYQSQNKENSFEIIKYLLDKGSDVNAKNITNKTPLYLLFQYKNENAFEIIKYCVEKYPNLNFENETRKLLVPVCKFQTQFNSIKIAKYLIEKGFDINAKIGFYETPLYLALQNRNLKLIQLLMMNDVNIYDLSPFKITQGIIKKFPKIYSINEDLNNLLKSNDNFSDFQIQSNDSFKFQVHKQFLLLRFDNNETILQKFIDICSQKSKEYVQIALNFLYTGFTDFDYFMKKFHNFANYRKQLITNQKNLDLNKILWPEYHQKSEEIKKLFTKNDEKFKEENEMILTFFKEIGIDSNWIEIKKGRKGIIKDLSKLYEENETKDFTIICSRKRIKVHKLILIIRSELFKGMFLLNVEDKSNQVHDYSGKSFETIYQLIHFIYHDKFDKSKKIRQETKKEYLDLKDYYQLNQNSIINLILNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R935</accession>
    <name>A0A9Q0R935_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cathepsin l1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R935"/>
    <dbReference type="OMA" id="HGCHFFN"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000039">
        <property type="entry name" value="Cysteine proteinase 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040214002" evidence="3">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="5">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="109"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="331" mass="36954" checksum="E309F737174E07DA" modified="2023-09-13" version="1">MKIAIILSLLFIFATIYAETDYKELFQQYKQKYNKKYDLEEESFRFRIFQERVKKIAKHNSENKSYRLGINEFSDQSYEELSRYLINEKTVTEKPTQQKGEKKENSIKSPDLFDWRTKGVVTPVKDQGSCGSCWSFGTTGCLEGCAAIDAGELISLSEQQLVDCDSTCSGCGGGLASNAFAWIKGNGGICSEKDYPYVAVDQTCKTTCKPVATLTSDTQSTYGDENALKDNCYNYGPISVSIYVMGDFYDYSSGVYYNAKCPNTTHNHAVLVVGYGHDSNSDMDYWIVKNSWGASWGLAGYILMARNKNGMCAIASNAYYLEGCSIINPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA17</accession>
    <name>A0A9Q0RA17_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA export factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA17"/>
    <dbReference type="OMA" id="YSHNTRD"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="323" mass="37154" checksum="1A9770A9045F9E32" modified="2023-09-13" version="1">MEFTKIEDNPPLDSVSSLHFTQKPENLLTATSWDNFVRIWSIDKDKAKFIGKQEFSSAPLCSSWSYDSKALFIGGTDNQAYLWNLEKESIESFGEHSQPIKEIFSFPENQNLILTGSWDKTIKFWDLRQGQNPINTTFLEGKVFSMDMRFPYLVVVDSTKGIYAFDLGSGYNCVQRTRSSFKQARVISLFPDLKGYAFGSIDGRVSITYLKEEEKDNNFSFRCHWKENEIFAVNDIAFHPKYGTFATVGSDGLFYFWCKETKSKLKKSIPFENSITRCSFNHDGSIFSFAVGYDWHKGFIGSTAKKERSLCLYLPKEKEIQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAB6</accession>
    <name>A0A9Q0RAB6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein constans-like 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAB6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="182" mass="22073" checksum="196C406CCC671179" modified="2023-09-13" version="1">MKQFNKFSGWINYIYKSNKWKRERCYVVVEDNTIKLFDNDNFNQEKKIILLDQNILIRFPEKEDKFLKLKDKSLVFQIFKSENSCELFAFSFDSCEETKKWIKDLIFSQNFSSNPELIQNKIENENQNENQNQIENKNQNENQNQNQNENQNQNQNQIENKNQNENQNQNQNQNQNQNQKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAV7</accession>
    <name>A0A9Q0RAV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mediator of RNA polymerase ii transcription subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAV7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417:SF7">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN EAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24417">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE LMTK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="928"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1078" mass="126933" checksum="779DB0DC92765845" modified="2023-09-13" version="1">MTFYSQIDPRNLYLIDQSKKQNLRPKSTFAYSQNQLEQLKENQLKEKQIETSKNESNLIEFDSTTFDSKNSLNETELTNQLQKKRKEPFENFQQHSYNMLTRNQDKSFLKNQIKQKEKHFEREFEKELKKENNKQNEVQKESSVKKSKKSNKKSKKQKNQQSFLKKQQNQKKTTGLRYSSDEEIVSNSDPSKIIENIHLAIPSKTEPQKASTLPLQSSPKTISKPIKKTTNDTPNFSPIQSINSKKVHNSNEFIHQIPVSKTQTQSPKDQKQNLDRNSDSLNSPHQLPIPPFPLNFPIFPPNGFYPSQIQSNSFFDNSNSQSPFANYIPSNNQIYQQFLAMNTPYYLSRFFPPFDPNNQNLNGISQSNFSDKNFAQVSQKSNNSNQNQIKNQKENQKENQKENQKEIENEIENQKENQKENQNQKEIENQKENQKENQKEIENQIENQNQNQKENQNQNQNESPKFIPNYIPNQLNNFLQNPMATYNEEAFTSYYNNQMKGESPLNGTKHAQQMTTPTEKNGNTEFLSSNNGISSNQREMNLEMQKMDEKNPQEMQEAIPKIPFGMMNQDENMTERMRFANEFFIPQQNYAANILNNQQFETFQKLSPLEMSIVAGMQKLSNTPDVTNKPQEKEHRNIPFLNGNIHQILYDNKTSPKNEQNFENQKQDKKISKNKKKVYNTRNRSRRNVEENDYSDNEMNDNDGDYFDNVETYDPNDDVYNENFTKISDSIDLTQKGSKKEKVDHHHHRKSESGLKINSYKSSKKEKNSTEKSTKEGDSEITKEKGILDTFPHQKELIKFFGKKPKPRIGERLDKIAEFFEELFDGWDSQTFMKFRETGQVPSAISIDNRVFWIMARVTFPQKVDLGFFQRKSYNARRGVSKFLKMNFKMENVTQYKHGRLVFHKRKPQSQYLNPNTILGEDGEESQDNQNQNQIQIQENQNENQNQNQDNQNQIQENQNQDNQNQNQNQNQNQNENQNQNNQENQIQNQIQNQQNENQDNQNQNQIQIQDNQNQDNQNQDNEETQDNQIQDNEEKNQDNEESQDNQNQNQIQENQDNQIQDEEIQDNENQNNQNIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBD7</accession>
    <name>A0A9Q0RBD7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beach domain-containing protein lvsc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="FDDAVIH"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="2660"/>
            <end position="2775"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="2788"/>
            <end position="3079"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3350"/>
            <end position="3382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3396"/>
            <end position="3437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3155"/>
            <end position="3251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1331"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3160"/>
            <end position="3177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3179"/>
            <end position="3200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="3202"/>
            <end position="3212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="3220"/>
            <end position="3248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3567" mass="417170" checksum="E4FC26BD17F1EB76" modified="2023-09-13" version="1">MKIGTTFIELYNNWEPNYQEDEFIKQITQEKKEEIQKQSQIKKENEMKKSKKNRQRKKDQNKQNEDEIDPEVLEKIVIQEAINKDYAQPIEFIIRFLRVLITYKTGLMEEIEKRISNQQEELNILAPIALEVISILSRSKFNRNRLINYGLFQEVVEIATLTNDLFSFFLNKDLQSKQKEKEKEKEDKIITLNLFQTQNLLLIEFLITKILDIISHFSMIKPTYLNESFFSNFSQSDKSDLEWIIKSGLIDSLVSFLEKMRKLNEFVLFNQIQYNIQINLINTMLVISSSGLLSNETFYRITDILIGMLSRPNLSLPGLKIHSFEESQKNNQNNSQEKSDKPIITSEVLYYFFIQNYHQEHNPDLSGNDLLSTEQTQNIEFQIRMVILQLFRELIADNANAEVQVGKNVKFSHLCDFILWVAQNFPSDIVASFIQENNNLIETKLSEISKKKKEQLLDQIKRQSKETTPIQFNFSSNIDFRLNEKNIYDPEEFKNNLPREVLITKNFDISQCNRITKPVRKVQNVDNPYIHRLFQILGDICLESTNNSQAIRQLKSNQENITNTNTNTNTNKNTNTNTNTNQETKIFTETSWKNIQTWTSTSEIDMRIKDRILFVCLDLFHYNFHKSFTNTNARNFVLSISPQLQYEVLMLFANSLDQESLDLLGSRNLWQIFFSNFFYYELNNDFIGPPKSEELLFQISDYLFKFITYVGSNEKITNIEECKALVNLIKENWFNLNVITQALDSLIVILKNVPKMTISSLYQIKAIKIFTDLSKDLFEFQTFQNCLNEEQKKKYINKCVSTKEWKFESETKKYSLDLVYETRLKLFEVIDVFFIDFEMRSKFIEENDNDLLLNKLLLCLLLEPQIQKYSLYQLARFMLAAPEETPSLIWFELFTSFIEFLMSIHQKQERIMSQKSQSHKFILLIKSILFATSSCIFQHQNPLQQLFVSAGSFQMLVTFLGSSLFGNNLIVDVLKVFIELFRGNRENMLEFKYDVGYKSLGNLIYNAEFKNPSISTYNLLLNMVVNNNYSPPIFENENQNENDLDNANQNEYYHDDYFNGMFPYIDYNYFDKEKNFLIQNPEVIMIMFEMFSKGKRKEDLQIFYNLLETFSEICEMSIHNASCCCEVGLVSFLANLIPNLQSYEEYFEKEKEDEDEEKKKLLQIVLEQTIRLLGVIGSHSMTVKELKTLFILLKSLKGDFRPPYSHLLLEAMQKMLGSKSIDKKIQPKVFFDFNGRSSCLEIPQLDKWPSSKGYSFSTWLRVENFEDPLSKPNYEPRILSFLNESGHGIEIYFKYRKQANNSDPKSKSSTNTNIENEIIPNVNQTKIKLKKKHQTISLDNLKMDLQEMNENSEDQNLDLSRYSEPIADLVLKVVLPNKVDYCTFPFYISLRKWCFFAITHSSPRWTSSGEVKFYIDGFCVGKYPLKYPNINFPLTKNRIGSNFIVKQKDNSNSQGNHFFGQMGTIYFFTDALHQTQITGIYQLGPDYMSSFEDASFNLVSTTSNSPKTIRKTMSYSGSPLTSPYTINALDGSLAEKIFFNFNSKACDLHYCIDQSPVSVIQKAKIVGMFKYVSRDLEDIIHCLGGIKILFPLLAQLDQPAASPQNLKFLNMDNFSKEKENENENEQNQTNLMDFNSLKQMIDYSIDPNMSGQILQLIFQMLVQSTSNQEDMKRSYGFQIISHLLQTFSPKHITINVVKSLKTFIMSIQNQDLLTDLINNFVLDFDNWIYSSFEVQIKLIKQVFLKVLVPNSLNNFHGKISTQDIMNILRLYYWITAETYSKGIENRFHSVTKELIGKRPSLEESKQIRKLLVQCITNLILHSQNSQEISSVIMYSFAMIDINHTDEIKDILLVIHDLIHTDAKCKEWSNNYNKDSENQNQNQKKQIEKETEAQKLKLLDSLNSFKFMDTFIIFLNSDDDDLRALSLHILYDLGNYSDLYPKKKWKSRLISKKGYETIHNILISHSFTKKICNVLFSILVSSQAEITDESQDELFNSLTIKRSCVLETIFSFIQNNDPKELTVHATNTIINILKGNDKNKEIMIKQFGWQQWLIDIYLSKMNKKQNSEDEQKFQLFKKQIIEGIFTIFRIIHIYSIFSDKNGTQYFEQTTHFVQNTSWETENMEINFLRRLYSDIISEIKQLISEKKGIKNVVTNSAIFADNFISLSDLFSKFVSFTYKQVSTKKSKKDGEKKLLRKESMALNQKLKNKKLLRRTIGPEYFRILNESLNSQDQENTDSKPKEIKEMNELLTIHKNYGDFILTSQFRMKGMDWEDLDIIKDFINLFSEIGLVYLTKSKSVISEKEKLKFIIQNIISIILNGIKNFEIEQNDLFFEKLYDIFRNIQKISSLKPIRNEITSIILSCLFSALEDSNKLTFIWNEKEKEKEKEKHLDSILPENVVDDNQEKIDNEMTKPQENLQQQKIEKKYFEKMLLEYIQKIFKKSYSFLASTVRDKSGILLLPNNKSNSSIFHQTKEQLITTFSNPDWKSAIKEFFHKEVDKFRIEKEIECKIYSQEIITSKKAISARKWTWALRSVSNERGPWGSRDSSNAIHWKLDRTEDDHHRRKKLKQNYHFDNHFEASIRRDEGSREAADKIIIETYDKMQLEKMTNQAKKSLSGIKMIANIDGEDNAEDEFDDSTVNYNKGDETSTMESNENTPTNINVKKVIYRTECSLLSPLTIIPGILEISTKSLDFYPNKEAAIEANKDSTLDKYNILNRSADTIFKDRSWQLKEIRKVYKRSYRLRQSGLEIFLTNKKNFFLHFPKQNRNVVFRKIINLKLPNIFKIDSGRPSEWLRKTHLTKKWQKRQISNFDYLMELNVIAGRTYNDVSQYPVFPWVISDYDSEDLDLNDDKTFRDLSKPIGALNEKRLQEFIDRYESFEDPDNVIPPFYYGSHYSSTAIVLYYLIRMEPFTTLSIKLQGGKFDHADRLFSSIGQTWKNCLTNSSDVKELIPEFYYFPEFLQNFNQFDLGKTQNESIIGDIILPKWAKNSEDFIRINRRALESEYVSQHLHEWIDLIFGYKQKGEEAKKAYNIFYYLTYENSVNIDLITDERERKSIEEQIEFFGQTPSQIFTKPHPKRYSLAKSNAIPLYWDFSKYAKIYTNSLDLTDSGILFVHFDNRLTIFDKKRYLSTFKLIATSTSNKPNSLSRILSLKKSTSLNQNENNENQNNENQNNENEIQDKNDKSLDEQETDPSKKIDVLNETDTETEIDTENISQNENENENENENENENENENENENENENENENQNENKNQIQNEIENEIENKIQPQETITEMTKQIENGEGIVFEVESLMKGIKKTVGVSFAFGISKMSNCFAILGNGKIFFSCGFWDNSFKLTNLDNSKLIQSITQHKDIVTCLAIDHEILVTGSRDTTVMIWKIDLREGKVKEKPKNILYGHDDEVTSVDLNQELDIVVSGAKDGTCIIHSLRNAQYVRSIFINENNENNKNDSNTQSIISMLKISNEGNILVYSDNDLSIRLFSINGKLLKIIDTSQHINSWDLTRNDQYLITGSEQGVIQVRQLWDLKNIYNFEFNHPILFVCFTSDEKHILAGFDNGTLMIGSLSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBP4</accession>
    <name>A0A9Q0RBP4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBP4"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="65"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="2">
        <location>
            <begin position="209"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="417" mass="48212" checksum="C7880F8092EDA544" modified="2023-09-13" version="1">MQKKEEKIDQKLIQSLTNFFQQTSTKEKEKEKENSISIQDLTNTLQQSLLQIKQKETESKLQSISIQSENFENIPKILQIMNNFPSNDEIQLNGIVQILEYFIRKRNQTFGENIIETVIKVMNNFPNHEKIQENGSLLLYGIGGNNQENQYQITKLSGIETLIKAMNNFPNHEKIQENGCLLLYSIFDNNQENKNQITKLSGIETLIKAMNNFPNNDSIQESGCLLLYVISEDNQENQYQITKLNGIEIVIKAMNNFPNNDSIQENGFLFLYTISENNQEIQNQITKLNGIEITIKTMNNFPNHGLVQLFGCGFLYFFSHNNKENQNQIRKLNGIETIIKTMNNFPNIELIQVNGCAGLSSISQNNKENQNKIRELNGIEIVIKAMNNFPKSLNLFKKMDVYFYQVFPQIIKKIEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC09</accession>
    <name>A0A9Q0RC09_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC09"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025271">
        <property type="entry name" value="CCDC28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13270">
        <property type="entry name" value="CCDC28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="135" mass="16362" checksum="EFF86EFCD7667684" modified="2023-09-13" version="1">MDDFENLQQENHLENETGKIQQMEQELDKILSKFENGELNCFGKEQSKIFSEMDKFQQEHIQFATDHLTLIKKIEFDEDFEPEKEDLKSTTFQFEKISKSFTQKEKVIDKFTIRMEKLFRDFERIHHMIESSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC12</accession>
    <name>A0A9Q0RC12_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">dihydropyrimidinase</fullName>
            <ecNumber evidence="8">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_07889</name>
        <name evidence="12" type="ORF">M0811_14813</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000051">
        <property type="protein sequence ID" value="KAJ5078668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC12"/>
    <dbReference type="OMA" id="SAETHHM"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006208">
        <property type="term" value="P:pyrimidine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000001">
        <property type="entry name" value="Dihydropyrimidinase like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="52"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="9">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5074846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5078668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="55389" checksum="85A34FB89620C7C5" modified="2023-09-13" version="1">MSKILLKKGTIINADEEIPDVDVLIDNGIIVKVDKEIKVEENVKVIDCTGKYLLPGGIDPHTHMQMPFGGTYAKDDYPNGTKMAIIGGSTLLIDFICPSKSNPSLVDAYKTWMEWATDRIHCDVSHHMCVVAYNEQIGKELEICVKDYGINSFKHFLAYKGILQLEDSYLFQSFKRCAELGALCQVHAENGDLVVEGCNNMVERGIMGPEAHALSRPSYLEGEATNRALMIARLANAPLYVVHVSCKEASDAIMRAKQDGQVCFGESLATHLSKDDSAYWDKDFDVAAAHVMSPPFRPKLHQKALWQHIQNGVISTTGTDHCVFDYKQKRMGFNDFRKIPNGCGGIEDRPSVLWQLGVNSGKISRRDFVAITSTNAAKIFNVFPQKGVIREGADADIAIWDPKATRVISGKTHHSYIEYNMFEGMEITGVPIMTISRGVIACEHQFVDGKIDWKNPKINVDTKHGRIVKRKPFSPYVYSRSIYIPDPEIKQTKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCW7</accession>
    <name>A0A9Q0RCW7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCW7"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="546" mass="63195" checksum="6DDE5B4C5E942672" modified="2023-09-13" version="1">MEEKSIEQKAAEQRQQNFMQFVINHGYSIMKHEIDTKDDYELCLFSIVNEDVPPPFKQFKTKPPVFFQHGLFDSCFSSVLDGPKKAISFLLADEGYHVFIGNSRVNGFSVGHKKYTERKDAYWSFGWQHMAEFDVPANLNYVLEFTEFSKICYIGHSQGTSQMFGALCLDKKRKLTNYWENQNKGKESDSTEINLEKSDSNEINLENDSNEINLEKSDSTEINLEKSDSNEINLEKNDSNEINLDENDSNELLNQDPNSHGEIELLPDEITENIEEEKIDGKKIGRIIEVDQEFVKKIKDKIQAKSDKEYFDISDKLEMFIALAPVCYVGNVGNALLINLASFNTDFLLMKMGIRKVDTHAPLLRKFAELKSSKTNVSKAVSGLLKFLDGSQIDPKNLPLYSKYLGGDTSIMNLRQWAFEIRKKRFHRFDYGSSKTNKLHYSESEYCEMDLDRKKKVNFKNPPSFDLSLLEEGNPKIVLFYGDQDRLADLKDVELLLKTLKFKPFYTQRDKDFGHMDYVLGMNAPEKVYKKIIELIKNIYQEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCY1</accession>
    <name>A0A9Q0RCY1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCY1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="490"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="593" mass="69022" checksum="A043B5045B83747B" modified="2023-09-13" version="1">MNEILFFGQNYDPKLIKNKPKKIKKPIQFKFENENENENENKNENQIKQISTGNFSTIFLFENGKAIEYLSENDSNQNPEKIQIENIQKVTVGYSNEAILTIEGNLFAKGEDINLDNPNEFINISSLIEDTNDRVIQDIVSGDSSVYLLTSNQNAYGIGSNYYAENSFDSEKLKKTEKPILMMKNVSKIFSGNNSEYVFLLNSNQELFTCGYNYYGQLGLGESRRRETIYKLTKIQNIPKGKIIDIQCGSIYSIMLIEDENENPKRKLYSCGNYQYNGVDKNEHSYEFTEIKSSLFENENDNILDFSCGGYHTLILTSNSKLIGFGGNDCGQLGTGDINNQSIPIQIELPKLRFNENISNYHISCGFDKSFLYYSPSFSNLEEDLIKLFRRKEFCNISFKTENGEIISAHKLILKYRLNQNQNQIEKLQEIISTKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD34</accession>
    <name>A0A9Q0RD34_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD34"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15949:SF3">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="167" mass="19631" checksum="474F06D0CC1D72D7" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDTSNKIFQKVEIKEKKMEKQVLIFEPQVGHYKNTPKLINKIKEKLLKEFAIKPTKGFGIFYDNPKTVSWEDCRSLVGILLEEADFGKIENLREKKFKVEILDQMDKNNKVGSIMEIYDGVPGKIFYIRPKEHVSIFDDVDDFVSREEDKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD52</accession>
    <name>A0A9Q0RD52_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_06621</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1760"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1772"/>
            <end position="1788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1788" mass="211876" checksum="893946335E9AF3D5" modified="2023-09-13" version="1">MNSVVNLFKYYILNSPNHFISFLFSKTLGNFIESTNSENFEYNFTNSHFNLLIKKLNFLQKIINEKLNYLQIPLKFCTGFLSGVEISIPTSLNGCFIRIEKIDLKFEMNNNKMQSFKSPQKSNNIDKKEIQDENFSENFSNEKNSFNHILMNIILNTELFIHKINFVVDVFDEEKNSIILDIDFLSLKQFIFIQNDEIIKSFTQNLKDFSFLHSALSRRIKFKKISISIQNLENLKTLFMIQGDSNLIEILEHFNKNVDNKQKISSQNNSNFPIIIKAVIDNIFIQFDESTLEKLSKIITNTLKKFEIILQEEINNEENSKINEINKSFSEFQNNNNNNNQSEVYQFLINQKKMQKEQLDELTQSIHDIIYIQSRNQTDTNESEFSEENSLNLRLDFHLDNLSIFYVYDQSWIDLFQPKNREVANFEFAHFHFKKITFNLEKAIQQYIKFSFEDILVQENLKKNGTLYKIEVIKFLQERKIEEENLQRFNLKMKINKFLKENTIEITLDSLKMIFDFKMLIRWIPLLRFINNKFNQNQDENENQNQNQNQNQNERAKMKFTISPFNIQCEIPIFTEREPHFEDYYNYEQILLLNIKDLQIFNEENGENLNFSFKYMKGYFTDKLFKEIQNEDFFNLIINGIFKEDQEFIDPYFTFKMKSLKDLQEIDSEKLDKIKFQNDNRKDYFGNYDYLPIFGDDSDFISQSEEVLKYTKITMELNFPFVKFALLQSDVSLLLDFFLFLDLFSTKLDQELFPNENELSKRKIPPTKFLLKMNMDKVVVVFEEHQENYYKKALLPGRHSYEFEFSQVFGINITNFLSDKLIYFFIKSQDVFLSDIYRDYQHNNNNNNNNNNNNQDQNVKDIILSRIPLKKKFEKQEMITFSVILNSSQNHLNKSDFSKELILNLNIQHFKYSYYVGTSFLSRFVDFMNTIIDENDAKDYLLNINNRNQPIQKAIHFNITLKDFAFEYFPINISPAIALVFGYFNFYQRIMQGSSAIKLNLLSENINGVLIDDHFELLFSNEGNNSLEYYILLGFLPILHCDDLKIDIIITKTDSNSNSNLNLNSNFKSGLLTEIDASENGLESEMCSDSLAFVLNLFDHLNYGYDLEKQFQPVFPEIEVKSSDKGLDELEQEDLYENWNEIENENENENENENEIGKGIEMKNHLDQPFQIKLYENPLQNIEKNDEIYQVDEYTDYTVLWKDDDSIGDIKPSFRDYLSISYLWEDQIEEDFPVEKANGIIKLKNISGFIRLYGGYDWETKKNQEEDDKEIEKIEHYKELEEKIEDIFEFDDAFMRYSLELEKSLEKNQDDEKNDEDIEEFEDVFTIQQIEQENYYSYLKPSKKESKSRKYLLEKLIEENLIQNKYLHKTKLQKSQRTQDYLDFIFEEGSLELFTFPNKEIHKLCLDLKIKNLLIEDHIQSSQYLSLLTYQTRFRDNKDEFIPMIHFRFMIVRPNPLIKTQIIEATEEWRIQIQVLPVRMNIDIRSLDFLTQYLSNLNQEREKNQKIYKTKEPFIQSFSISKLYGDFSISYPLNDTVSFAVNHIIIRLPSVHLFGAEWDKAIEELKNQYISSFKQKKQLVTVVGSLPGIKTIVNISKGFKDFITQPIKSYQNGGGFITGVWRGTESLTKSVFLEILKAAKTVTKISELSLFFVDDKNMELSIKHGAQQPKNISQGLKFAWEDISNGFYYVLKNLNLKSNQNQNQNQNQNQNQNQNQNLGLSHSIYIKTTSPLMIPKSIFSALHSALKGFINKIDPEQYVQDVGKYKPRKKKDNQDNNDNKDDDKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REB3</accession>
    <name>A0A9Q0REB3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rcc1-like g exchanging factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REB3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="288"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="395" mass="46620" checksum="1060938C9E2E2DEE" modified="2023-09-13" version="1">MMKNVLKYFQELIQDIFFFLNPNQELFGCGYNKGKIIDIQCGINHSIMLIENEDENQNQNPKRKLYSCGYSQDNGLGKKNGNTYEFTEIKSSLFENDDNILEICVGADHNLILTSNSKLIVFGGNWYGQLGTGDTNTQSIPIQIELPKLRFNENIYDYHLSCGENNSFLYYSPFLSSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISSKSVKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKYFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIKITQEIIDEIKIGIDYFQLNQTYPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REK5</accession>
    <name>A0A9Q0REK5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ngep-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REK5"/>
    <dbReference type="OMA" id="YNGPLKT"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="227"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="681" mass="78915" checksum="C36AA5834C603BEE" modified="2023-09-13" version="1">MADQDNLNLDDQDNQVQFNTEHSEIAIDDTTKVDDGKDIENDDDKIFYEWVVVFAEQDLTDNGCCKKVTEDKLEHAERKKEKIKTWLTGAGLKLRETSSVGNEFTFIEIGASNHFLERWAEKSKLRVKIAGMEGPTYLGYAEFRMSQKNMFLAHSEECVFNSSERQKIIRTVIEAKKDQGGCGINVTKLIRKKYATDMFSVHNYDELDPLLKRWSKSCKCTQPIDQVRDYFGENVAFYFTYLGFYTEWLIFLSIVSIPFGIVQIAKAKVDTPAILFYSLFIVLWTTVFVETWKRKSNTKALHWDTLFYEREEQIRPEFKGKIRMSPITNEEEPFYPGWKRKLKYIGSYFVIFCFITAAICASVFINKKKLIDNDKHIDFGYKVWTAVATGASIFVLNFIFQRVAPRLNDWENHETDTKYENALIVKFFLFQSINSWTSTFCIAFIAQDITYLTTHLGSLLIFRQALGNVQEVFLPYIRGKLKIRKEKKRVKALRDQGIDVPDVSMIEKQAKYPRYSYTIDDYSEMMIQFGYISLFSISFPAASILALLNNIIEIRTDSFKLKNMKRPEPRPANGIGSWIIILEILSFLIILSNIALVAVSSTEQLDYYFSDGISDTERLWFLIAVEHILIVLKLLLRVVIPDTSQAVDDAIAKDKYEAEKNQTLMLHKSFYAKDVLDDDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFE7</accession>
    <name>A0A9Q0RFE7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFE7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="58169" checksum="0963E656DCBD238C" modified="2023-09-13" version="1">MQKLTEEQETKFLHFLKVNCEFEEPKTKFYSSKDIETIFSLSETSSLIIFDYIDKQKERTITFNQIAEFLAIFTNGEPSLKGKELFHLWDQNKDGFIDRKEAYQFIDCVLQISVSQLKQVIEGITSSQSAMTSFLEGFEMGMQMTSEYQNQNKNQINSKQNQPKLNEEDAKQILEQSMTTLNLQNPETINGVVDEMFKQTDIDKDGLISEKEFVHHFLNEYHSPLHQFLEHITFIFKDENEMLNFHQQMTELMKIPTKNVEQKQNPKTVEAFNPFDFIEMENFKKKQNENQEIQNENQEIQNENQENQNQNQNQNQENQNQNQAFDPFQQDFLDSKFYFQAFQEYSNEIQFPIGNFPEFDGNAKENEEMLADLKEKIKEFDPIIGPVFYQYQTVIYFLIFLLEMGMLSINGWEKVFEEGDQSIRGFRYKKGDKRIMVYLKDIENGSQSILAAFVPDPKKLPSLDKEVPIQQNIQNQDNSEKSQQNSNTGECLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFJ7</accession>
    <name>A0A9Q0RFJ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adp-ribose glycohydrolase macrod2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFJ7"/>
    <dbReference type="OMA" id="CTFMPID"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="63"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="245" mass="27721" checksum="9B8BBF70B820D719" modified="2023-09-13" version="1">MSEQEKEQEKEQESEKELEKELEEKFEEKKPLEYIPLSEIVRWNAHAGLYLAKTHPDWIKESKKLYGKNEEINRKIGLFAANICHIECDAIQNSANGNLIPGGGGMNGEVHKNAGPELSEACLKIGRCDPGKTKITPAYHLPSKYILHSVGPDDQNLDLLKSAYQTALNYVSDKTFQIKSLALAALSTGTHSIPYEKATRVALSVVRDWLDVKDNLDNIDLVIFVMNSPQLFEVYERLMLEYFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG93</accession>
    <name>A0A9Q0RG93_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG93"/>
    <dbReference type="OrthoDB" id="2439862at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="165" mass="19016" checksum="BA73B63B973DAB3B" modified="2023-09-13" version="1">MKKGYSAKKDGFGCDKWHSICDNKGKTLVIIKTKQNFIFGGFTQVGWTNDKSKWREKYRYNDYGNIPDSNSFIFSLRNDKGDRNSEKFTIQKGKEQKAIYYDLDIGPSFGGCDIWIDSNLQPGYSNFGENYNLPNGIKYETNEAESYLAGSPNKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHB4</accession>
    <name>A0A9Q0RHB4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000015">
        <property type="protein sequence ID" value="KAJ5080067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHB4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="147" mass="17864" checksum="A3B3CB1102D39C0D" modified="2023-09-13" version="1">MKDIFEQIGIESNWIETKKGRKGIIKDLSKLYQQNETKDFKIIIEEKKEIKVHKLILILRSELFKGMFQLNVQDQSNQVHDYSRKSFEAINQFIYFLYHDEFEEETKITKENLEEYVDIKDYYQLNPKSLIGELLLDFDYFKNIFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHZ1</accession>
    <name>A0A9Q0RHZ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHZ1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="488"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="623" mass="72548" checksum="BE4FEF579230B5E7" modified="2023-09-13" version="1">MNDCLFFGRNEYPIIIKNKPNIITKPIQLKFENENENENEKQIKQISTSDFGTIFLFENGKAIEYLKENNSKQNPEKIQIEENIQKVTIGDYNEAILTKEGNVFAKGKDINPDNPNKFINISSLIEDTNDRIIQDIVSGSISIYLLTSNQNAYGIGSNRFGQLGFDSETLPKTEKPILMMKNVSKIFSGNSSNHVFLLNSIQELFGCGSNYYGQVGLGESRKQERKIQKLTKIQNIPKGKIIDIQSGWPHSIMLIENEDQNQNPKRKLYSCGSKYNNGLGKNENAYEFTEIKSSLFENDDILDFSVGYEHTLVLTSNSKLIGFGDNDFGKLGTGNTKQQLIPIQIKLPKLRFNENISNYHLSCGDYSSFLYYSPSSFSSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNENEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIKTGIDYFQLNQTNPNLFDLLINKFNNQNQNNKKEKIQKERKKRKPFLEKEIIKIKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5H3</accession>
    <name>A0A9Q0L5H3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000141">
        <property type="protein sequence ID" value="KAJ5066501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5H3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="75" mass="8266" checksum="2A49657E43699D35" modified="2023-09-13" version="1">MIQRGIFWILKLIPGDSEFPCIVKVLPALLIPKAKTIAYRESGLVIIDRINGSVDVSNTVSCGVSGSKYVIEREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5J1</accession>
    <name>A0A9Q0L5J1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molting protein mlt-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="588"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="654"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="777"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="835"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1264"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1356"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1282"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1356"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1369"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1464" mass="164366" checksum="E109F046C840489A" modified="2023-09-13" version="1">MQNDRLLQQSTTRFHNLCQTGDLKGIITFLNSTNSATYFLESKNEENQNPLHISIRAGHFKVAEFLIANGININSSEGKTGMTPLHIAASLGQSKTIKLLLEKWAIQTEVDSNGWTPLHWAMTIDSNSDSDSGTCIESFLEPGNKPPLEKPDNKGFLPIHIGIMKGSIKSVEVLLKIGNMKTILTKDKAGLSPVHVAAKYGQLGILKVLKTERINFNITSKEHRNALHYASENGHADVVRFLVDEGVSVELLDTNKLTPLALAQLKQHTNVCAILMKKGAKSMLHEHIKAGNIKKVKKLLTKRVDLEAFDDEGNPPIHLAIQMGNQEIIEILLTKGAKINSRNMGYQTPLQTSIEKGNGEIMRVLLRKKADLRLSDPNGNTSIHYMIIHKQTEILKECLTTQKPPISVLNIANKEKNTALHLCAIQGETEMAKMLIDAGADMSILNNEKQNILHVAAINEKPKFLEAIIKRPGFDPRLLDIQDKEGSTVLIYIVNSPINRDYEETINMILDKKTNINIRDNTGNAAVHYAIENSQMDILEKLLKKKPELTPNGQGIPVLHLSISKNSVLEGFKLLLNAGAGIDEKDREGNMPIHIAALLKKFKFIVWIEKKGGNVNARNKGLDTALHLCSALGCDVEVDFLAKHGAQITLANSIGRTALHLAAIKGHDKCVRVLLDHNADINARDSDGKTPLDLAVRGFHQTVVEMLIGSGAIFPLQQALENADAKLFKEGLEKGYSPDLRDNNGNNMVHLAIMKKNNEILQLSVGSKTALKATTKDGKNAIQLAAEWGDLDACRILLQAGVELVDYEDERMRPHIISEQSANAECTRMLTKEFKRCSAAFEILETEKNYVEDVDLLVTNLLPKMRASGLAKKDDIDAIFSNIEDILAVNKELLQALIARRNEWNATSGIGDILLVKSSLLRIYVHYNQNYENSRITLNRCLKNNAFAAFLRNAETEFRRLDLSSVLIKPVQRVTQYPLLVEELLSRTPTDHPDHPLVSSALVALKKVAEEINESKRQQEELQRISSISKTLRGLAFDLLSDPLRQLKHEGPIQLFRSTFLTSGKAPQKAKQKSQKTKSRQKGMSTTVNVNTALPSQESPTQTSVVENTESQIENDSTNISESEIDDLRSDITDRSEILREEKSLSVLGLASCDFILDHSEQKYLFLFSDILLICRPRKDSSYDVEHEIPTISLFLENQFELQKAGSLWNGLRVLSSKGSFVISSEKKSEIEKWKSLFLESIEESISIYIKSLKRMIVTDFHSSPENSEVPLPNEQNENENENPNQNQNPNQNSNSSIPPISPSFLDNDSIQVIKEIKSIQYNYIEDPLKNKNELKNENELKNENQLNNENQLNNENQLNNENQSKNENQSKNENQSKNENQSKNENQFEIPKIFMWDCLCFSLKSEQSIEQKRFFSVDTDAQSLIQNICKVIYPSLKFQNIPNYTRIIASLLYTQMQPFLYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L725</accession>
    <name>A0A9Q0L725_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron carrier/ protein disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L725"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="66"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="515" mass="61103" checksum="4870FF1B14DD274E" modified="2023-09-13" version="1">MSNTNQNNENINENINENINQNINQNINENINQNINENENNQKIKTDKSQQHQLIYQIIKETTNEKLYEVITDKYCISCFIKFCESIYSVESPLFIRDVIQYKKLSGHFQQFPSETEKKAIHTTSTKIINHYIRNNSAFEINIDEIIRQEILTQFEIESTFEIFDKALIHLLGIANDSLFPRFKDSLKYNEMQEMKKREKCIDEKEKSNQELHLIIKLPNNKNKNILNKRRWIGPSREPLVVSINLLHFILGMIRKHTSKKQTLNFQDSSLTVSFRRFLIGTSELKKVDLSEMKEIERKAFFLNIFHLLLLHISFTINIPVLNKNFFKTYQYKIGGYKFSLDDIRFGIFTNNSIRSKSNHNSPYFTSSDLRKELVVSYDPRINFVVSYLTLESPPITIFYPETLENQLETMCKLFFIGKKFKKIEKKKKIFYQFNLPKELSYLAKDFISNQKNIIHFIAKYLEEDSQKKFYQAMQNQIAVEIFFEKKTLQNFSIKFADKAEPIPKSYQKLNFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L771</accession>
    <name>A0A9Q0L771_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btb (Poz) domain-containing 2a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L771"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="56570" checksum="A7148F0D9F91C38E" modified="2023-09-13" version="1">MNFIDYLNNKELSDVHLLIGSKRQLIYAHKFLLASKSKVFKEQIEKQNKIITEITLDVDPKFLHFVLVYIYSGNLNLNLIQEENDFQSNIHNIYLLANKFLIESLQKECEKIMKETISIQNCIDLIMLSKKEGNESLFNFAINFLVSKKCIDLWKMENSLNKLNRDLIQEILKIEFIEIPEILVIQRAVDWASQSLSSNQSISINQFIQPFLNFFKFDILNLSEISTIARLNILDDKIIVQLISSLPKTRDPQKSLSRDSTWKKPSELIKILILTTASEKRTQNLLDSIISTKEIQNVDIINVEKSTPSLEDLLQYDGIFLLFLEKLHNSRLLGDILSKYVEPNEKNNNKGKPIVTSSIYTLVSSNYASLTGRIIDENFFPLKKGENQWGGIWKFDQGNVLDPSHPILQNVSSFNGGTSPEYIKPCILTHDAKIVAFSNDSTPLILEKKIGESYGKVILLNFSLISNQLDKDGWDSTTDGAKIIANSISYAIQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7G6</accession>
    <name>A0A9Q0L7G6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7G6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="264"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="392"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="482"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="612" mass="71602" checksum="230E111964680D8E" modified="2023-09-13" version="1">MNEILFFGLNKYPILLKNELYKIIKPIQFKFENENENENENEKQIKQISSGFFSTIFLFENGKAIEYLRDSNKNPEKIQIENIQKVSVGYQDEAILTIEGNVFAKGKDINSKDPNEFINISSLIEDTNDRVIEDVVSGANTIYLLTSNQNIYGIGSNFDCELGFDSEIFEEAEKPILMMKNVSKIFSGNSSNFVFLLNSNQELFGCGYNYQGQLGLGESRKETQIQKLTKIQNIPKGKIIDIKCGYEHSIMLIENENENENLKRKLYSCGDLQCNGLGKYENIYEFTEIKSPLFENDDNILDFSVGNQHTLILTSKGKFIGFGNNEVGQLGTGDTEIQLIPIQIELPKLRFNENIFNYHISCGNHNSFFYYSPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDELETGIDYFQLNQTNPNLFDLLINKFTKEGRKYKEEEKEKEIKEKEKEKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L803</accession>
    <name>A0A9Q0L803_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Factor cwc22-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L803"/>
    <dbReference type="OrthoDB" id="5393235at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="98" mass="11525" checksum="D3B902BEE2245ABE" modified="2023-09-13" version="1">MEINKELDEIANDWIEKMQKEIENKQESKKINENFQQNFSSSKFSQTKPRPPRLGLGASFLPHSQAIKLIGTRDKLRKQIQSKNENENKNENKNKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8R3</accession>
    <name>A0A9Q0L8R3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/thr protein phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8R3"/>
    <dbReference type="OMA" id="IFTHHAP"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="311" mass="36564" checksum="4032F1B8EDCFAF9C" modified="2023-09-13" version="1">MKKTQQNFLEAENPTELTVEIENEGEELSFQTCSDIHLEFFSEEKPYPKDMITAIAPILLLCGDIGNPDQEYLLQFLEEQSKQFKYIFYVAGNHEFYNVRNEEEKSTYQERISKLKQINSKISNVFFLERTSVKIIVHRKDNSKDYVIRLLGTTLWSSVPKKHSLNIQMMLNDYRAIYKTKTDNIKVTDTDELFNKNLLWIQEECKKSKKSKESQVIIISHHTPSMKSTSPDDETGVIQHAFCSKLDHLLNFKKTHISCWCCGHTHRSFNYFTKNTKLIGNQRGYFWEVEKTGYKPDFVFNLNLNPNQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L952</accession>
    <name>A0A9Q0L952_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L952"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="140"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="308"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="413" mass="48675" checksum="31AC5587D87F72BE" modified="2023-09-13" version="1">MMKNVSKIFPGNDSNHFFLLNSNQELFGCGNNEYSQVGLGESIKEERIEKLTKIQNIPKGKIIDIQCGYAHSIMLIEDENENENPKRKVYSCGRYFFNGLGKNKDTYEFTEIKSSLFKNDDNILEIFAGCFHNLILTSKGKMIVFGDNDYAQLGIGNTKEQSIPIQIELPKLRFNQDISNYHISCGDYKSFLYYSPSSFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLKDENQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYFEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIIDELETGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L981</accession>
    <name>A0A9Q0L981_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_02615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L981"/>
    <dbReference type="OMA" id="SGIFDHG"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08996">
        <property type="entry name" value="GH32_FFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="73"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="408"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="551" mass="63355" checksum="93508B8D2A116773" modified="2023-09-13" version="1">MENENLFDEQELDSTFPNNQKKPKKIFKPSILVIIIAFAISLSCILVGILYHPPIKYQTKSIKDYTEMRPLYHFTPEKNWMNDPNGPIYLASTKKYHLFYQYNPNKPIWGDIHWGHAISDDCMSWERLPIALSPTKDGPDREGCWSGSAFQDENGNVLFYYTGVTNQYSLPFNESQCIAIPINDSFLELEQYAGNPVISNPPFTDFTAFRDPFVFSYNSTNFSLILGSGRSSNSKANVLLYSSQDLFNWTFENILVQSPDNCSDTIWECPGLFPLEQTGKFILTISSLPRRQNTYYIGTYNQSLNSFIIESDQFLLDYGTYYAAKQFFDPTKNLYVLWGWVTEARSEEGQIEQGWAGVMGFPREIYAITNANYSEISVGFRPISQLQNFLYSEIDLGNISFNSTEENNLEFFTIKNFTSRQFEIKAIIEPKNTTEIGFRILWDLDSNEEFTDIVYYSQNSTLYIKRTNSTKLEDPEKFSQGGFVPLNENGIINILILVDHTIVEVYANEKYCITSRVYPISPKSEYISVFADNLAYVNNTIISKIKSTMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9M0</accession>
    <name>A0A9Q0L9M0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9M0"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="108"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="531" mass="61753" checksum="3A0AF243A9FF124F" modified="2023-09-13" version="1">MSTIPVFVKWKKEKFEINLALDQPPLLLKTQLFSLTQVEPDKQKIMFRGKTVKDTDDWNKLKIKAKANLMMLGTPANERLEEPKEKTIFLEDLPEDMVKEIEKKDLPSGLANIGNTCYMASTLQCLYYIPDLRDKILSINSSTVGLREDQIAPHKLAVELKTLFNQIQQGNPSIYKFITLFRQIYPSFAQRDQLGMFLQQDAEESWTSLMNTLSQALIEKKDINKEINGTLPNQKTKFVSEWHKPVFNNAIEELFGIGMQVTRTCTETDKEFPSVSYEKTHKLLCNITSDVNFLFQGVQLGLSQQVEKESEFLQRNAVYNEESRLSRLPPFLVVQFVRFYWKADKGIRNKIIRVVKFPFTLDVFDFCSEQLSKKIQKKRIQLRELNEQNENEEKKKLEDAKQESMSNEKDPKQESMSIEKDPKQESMSIEKDPKQEIEKEKEKENNIKEISLDNDTGYYQLISVLTHIGLSADSGHYIAWAQTEPNKWYEFDDDDVSLIEEKDIEQLYGGGRGHIAYFCIYQKLDGLPIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBH0</accession>
    <name>A0A9Q0LBH0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBH0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="385"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="570" mass="68422" checksum="BF24AB572D38BCCA" modified="2023-09-13" version="1">MNNNNDNNQNQNQNQNQNENQNQNENLEKKVTKNLIKDYSNLLNGNSFKDFSIFVEKEPNTFEIKVHKSILSSRSPFFNEFLRDRDQINKIFLNQFNKKEMESILSYIYYGNISFENQENLLQLLEISIYFKLNLLKEFIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRINSLKLRKYEHKMNAKKRLFHSFFSLFDKDSISKQDFDKLKQFDIFLPNYFLINFERTIFEIQDQENQTKIKEKEKKIKRRDKRIKSFESETQNLKQENQKKEKDIQNLKSENEKKDKILKQKDEEIQNIKLSFEKENQKEESKQNENKLLKIFSNSEIIKDKEYVKKLQEWINDNDFFSKMKKGFSAKKDGFNSQNWHKAVDNKGKALVIIKTKQNFIFGGFTQVGWTNDKSKWSEEHGNWGYIKDENAFIFSLRNDKGDRKPEKFTIKQGKEGNAIEYDLNDGPTFGFYDFKLSSNLQSGQSDFGHSYNLPNGITYQSNEAQSYLAGSYDKWVVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBL5</accession>
    <name>A0A9Q0LBL5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBL5"/>
    <dbReference type="OrthoDB" id="47475at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="70"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="370" mass="44358" checksum="5EE26EFDC883FBA5" modified="2023-09-13" version="1">MSVDRSIKYSYTQGIPYLKNSFIFMIKVILKPGLIPKRRGRKRRIPIIKKIQIYDKDLANHNFQIQDVIQTIPNSGNSCYIASIVQILIRTLARNLLLLRDISEKLWDIFNSNERYIEVQDLRKEVGKHFVNFDNLNQQDLHEFFINLFELLNKETILDIPNQDDLLYHILDLWNKIILIDFFLFFFQKVKCLECKHFSFSFPQETGILLSLESEKDCNLIELLNSFFSKNYFDENNLLFCEHCQKVQSSFQFLIHIPKFFMIFVKRSFYDPILKEERKIWQEYKFQERFNLIIFILLLVLCQTHCHFGDQFITKEKNKKQKGGHFWTEVKDERNAGDFQVFDDSTTLTIPNPCRKSNSYVLMTYQRDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBP9</accession>
    <name>A0A9Q0LBP9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calponin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBP9"/>
    <dbReference type="OMA" id="WIKTITG"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001997">
        <property type="entry name" value="Calponin/LIMCH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00889">
        <property type="entry name" value="CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="29"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="217" mass="24074" checksum="BAB6313172AED7E2" modified="2023-09-13" version="1">MARYVEQNDDCVYGLSAEIKKKQESKFDPQKEGEVLDWIEAVTGQSAPRSVSGLKDGVLLCNLANRISPGIVKKINKMKTPFMQMENIGNFLSACRSLGVPPPSLFMTVDLYEEKNIPQVIDTIYSLGSVSQKKFAYQFDEETKKKGRAAIPKLTADVNKTANQSGMFDNSRNIVKLHAKSDNSTVPILTANVNKKANQSGMSFGARRQITNQTNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC42</accession>
    <name>A0A9Q0LC42_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC42"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="522" mass="63536" checksum="86633081F2442792" modified="2023-09-13" version="1">MDNQKKRIQTENDTQKSISKKEEKLKENENENENENENENENENENENENENENEESWDDSDSNSNYDSDSDSDSDSNLPRSRSKSPDFNQNQNQNQFPNQFPNQFPSNYSNEKRNQFNQEKPRYRKQYSKDQNYSEKPRFRNHNFSNFKNYPKDSNFRNYPKDSNFRNYPKDSNFKNYPKDSNFRNYPKDSNFKNYPKDSNFKNYPKDSNFKNYPKDSNFKNYPKDSNFRNFSKDPNFRNFSKDSNFRNYSKDSNFKNYPKYPKNKNYPNDSSPPKRVWKRPEKKDQNQDQNQNQNQNQNKNEFRNQNDENIKTRFDKSNPPRFQNQYRKTYCLEFKSDQIFDVRDVRTELGWDNTRVSPKYGVVDSCRVFFIDKIIFENSKQKNKIKDKVFQIKEIDLQNDYYTKKPFYKSNSQKFYSNYESKPNFQNKSKFSKSQDFKTNSNNKIIEFQKPNEQELTNQKKNEHETNIQKTEEIQNEKTRKTQRKKKKKKKKKSKNDDNQSNLRDQNRFGKLRDLINKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCQ4</accession>
    <name>A0A9Q0LCQ4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCQ4"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="562" mass="67763" checksum="87BA92067435F929" modified="2023-09-13" version="1">MNLNKNKKTPYYEIIQIYSNITYTNFIKEIYPTSKANKILNYIEKDTYNYTYNQQNNNYEDFSDKNIDLYSDINLNFIQKEKEKEKEIDLEIERKEENESYFDWLPEELILMIFEYLDKPIHLCICEATCSQFQRISNEPILWKNALRKTAPYLDFLMAAGYAYRYQTRSFYFSFKGVIGICKYFEEEHERLLKQKEEEKINYDGKEKEKENPLNNKINELVDNHIDLLFDDSYYDTNYYPNQNSKNKLYQHLPYDQFNSIYAYRVIKRDYKFFDSHPYPPNPQKIDKALKIFEGGVVPILFSLSFLIAIILSMLKLDLIIETNCVYIFLPVEISFCCLLYIGFCFYMTRDSRDFYHFTISMIISVISTIIFLILLSIKLEYSNSFPWFILLIPHLISFGAWIYFPVTTYRKIREEDDYLKNIMLSYILIFNIPITTFMILFILYKQNISGITQNSIFIPLFIIDILPTVLFIFWPIYLRYCRKHTDSWKSVRNLPSTYNSYLKINFISLFIYQIPMLILFIQELLIYLKLNQKIFIEWITVSTPSIISFGFIFDFWFDFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD25</accession>
    <name>A0A9Q0LD25_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_10772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD25"/>
    <dbReference type="OMA" id="NARCIST"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="8">
        <location>
            <begin position="686"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5070503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1086" mass="123496" checksum="E22CB9CAE8548173" modified="2023-09-13" version="1">MSQNIEDIKKTEKIDISNQNLKEIPKEIKKTKALKTFLIQQNEIQKIPQFMSKLRTLTTLNFSENKIETIPNGLFGLTSLETLDLSNNNIKDVPEKMKNLRNLKQLDLSINRISEIPKDILSDFMSLKVLGLYRNRIGALPFQIGSLRNLKELHLDVNKLEKWSPGISLLRKLRVLKISQNMITKLPEKLEIAGMSKLLNLDISDNFLTELPDSVSSFKKIKILIANRNKISKVSPLIHELGDLEVLKLDRNELKNFPENPQVVANSLITLSLNENQFEQIPAIFKEMRSLIDLSLNRNNIKEFTIELENLKGLDLSKNSISNISSSALSSLTKLEYLFMDHNNISHVPSSIGALACLRILYMSSNKIQKLPDTFCVLEKLEEISLSSNLINVLPKDIGRLQNLSKLSLDNNNLRKLPESFSNLRNLSVLILSGNKFKNFPLVITKLKRLEILHISLCFLTTLPNDIQNLSHLIELDASCNKLGSIPETLGKIQSLSVINLSGNLIQNLPADFFALDFPARKATLSIDLSYNLLTEFHAEWYKMDHLKELDLSRNKIGKISGGKFSKEMQLESLKLAHNKTQRVDLSSIKRLPHLQTLCLEGNTLSTKFTKTIENYLGDNIDSQERMQQTIVDNLSNISLQTNNIDTIYLTMHSLSYFPCLKRLLVSFYQKTPNARCISTKSLRRKVGYADMRGKREFMEDAFDIKAGMGTFSNIDIYSLFDGHGNDIVSSLAAKIIPPSILHHLTNHLVHFIQPENQSDFFINSRLSKLQNQPKMPSASQFILKIPKNSRIKMHKTRFISPAKKINHPNILKYQFENHDEKNGKKQEIKSMFNKIFQEFNNHIDERKEQGGSTAVVAVFIKDECYVANTGDSRAILVRNSKAIRVSQDHHPNLAKEYRRIRGLGGCISSDGRVNGGLAISRALGDLEFSPLVTCKPHVSSFSVSENDQFLIIFCDGISDVLSDQQIADIAVYSRSPSKAALLLRNTAYALGSTDNISVIVISLNPWKNKNSQVLIKKKKRNRNRKKNKIENLDLNNHFDFDLNLNENENLNENQNENLNENQNENLNENQNEIKIQNLNENENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDQ7</accession>
    <name>A0A9Q0LDQ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDQ7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="332" mass="39335" checksum="93FDDC4AD00FB838" modified="2023-09-13" version="1">MENIGVLHINYESKIKKNLKKEVNGTVKQFIHKNSFLTLNETNFSVYCSICDKELQGISKWKIQRHCRSQHHRLLIPLNLQQQKNEGRCNFDSKESALLRILEHLQTFSNTDFYSRKEIPTYRTGLSKKRIFKQISDSLPNVDYRKFCFYSSHYFCLKHNTPIFFQCEKCANPNPQKVANHRNKVQMMRNFFKDEVQDPTKLVIILDFGENIQEYRDGWNTQEFYIKNSWVIFNICLIQGTEFEYYDYISEEKSKIKNNEKLNSYESISIFSDGGSSLKNNLVIPTIIQLFSSNFKKITIGYFLTNHGKNYSDAHFGNISRNRSSFWEYKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE00</accession>
    <name>A0A9Q0LE00_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE00"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000093">
        <property type="entry name" value="UDP-GlcNAc:PI a1-6 GlcNAc-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="8">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="201"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5070951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="465" mass="53173" checksum="7CBA30A2FEED10F2" modified="2023-09-13" version="1">MIEEKDLFKPEEKRYRILMASDFFYPNVGGVENHIFQLSQCLIKRGHKVVVCTHQYKKRKGIRYMTNGLKVYYIPKQPTFRQTTLPTLLNSLPMFRNIMIRERIDIVHGHQATSCICHETITCAREMGIKTVFTDHSLFSFNEIGSFNLHKVSNYSLAEINHVICVSHTGKENTSLRAKIHPIKVSVIPNAIDASQFTPDPSKKTPGEITIVVMSRHTYRKGVDLLIQLIPIVCKKVPNAKFVIGGDGPNRVNIEEMREKYNLHDRIEMLGFVPHELVRNVLTRGDIFLNTSLTEAFCIAIVEAASCGLFVVSTAVGGVPEVLPSHMIKFAKPDAEQLAQAVIDSIGPSQEVDPWLFHSQVKNMYNWDDVAERTEAVYDKIQFDVQQPLVNRIHRYFNCGTWASKAFCFALALQFLFMLILEWLMPANEVDIAPDFPLKQFLKNKDKLNQSWTKSYKVIERANEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE92</accession>
    <name>A0A9Q0LE92_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein sip5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE92"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="231" mass="27195" checksum="9E083330B503A36C" modified="2023-09-13" version="1">MGNNNSKQAHKIYTKSTGIYEKIKWNENTVKKRIFKKELAPLYPPESNKTETTREECPICFYFYPTINLTNCCQHSICSECFLQITPNEPTKDNLCPFCQKPNFTVKYTGNRPKEEVLREEENQKQIEQANKKAQIRESRIRKQNKEVFKKIVNEQLPRQKQQAKIMQIMEENNANSFKTNSSPLPIISDNFHHIQVFDDVFDQTISRSIDESDLNYNQLQKTLELSLHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEP2</accession>
    <name>A0A9Q0LEP2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dentin sialophosphoprotein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEP2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="119" mass="13575" checksum="05118AF732EDF532" modified="2023-09-13" version="1">MKLKIQIQNQNQNQNQIQNQNQNQIQIQIQIQIQIQNQFQIQIQIQIQNQFQISKSKSNSKSNPKSKSNSNSKSKSTSKSNSNSNSNSKSKSKSKSKSNSNSNSNSNSKSKKFKIKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFS1</accession>
    <name>A0A9Q0LFS1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFS1"/>
    <dbReference type="OMA" id="HREDEWP"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="344" mass="39859" checksum="E23F690221B76A6B" modified="2023-09-13" version="1">MFQITSCETLPQKGKEPGNTCKSGMLSFPEKGEIMIIGGYCQNRVSNHVKIYKTENNEWDDFPIQTDKENIPISRYGHTVTFYPKKNSVFLFGGYDLHTYLSDFWELNLTTKEWIEYNKNHREDEWPKGRHSHSCVLYEDFLIFFGGRITLEGNRSNEVWSWSIKDQTWNLIKTTGDIPSTRSSHSAAIYKDNMFVFGGVDEDGFTTEFFYQLNLTDFFWTKIHLGTDIYSRASSAFTQIGSRLILIGGRKTLPDFKEDSNNIIVIDLQNFETKLLENSPYFQGRSCHSCIAMDHDIYMFGGEQINLNSCPVIHVNYLEKFSFLHDLVSDLKNFLSNESILMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH05</accession>
    <name>A0A9Q0LH05_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH05"/>
    <dbReference type="OrthoDB" id="19132at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="304"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="56560" checksum="35B309E1C821665A" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFKNQNQNEKEEESYFDFEIICEQDKTSFKTHKSILSSRSHYFKSLFKSKMKEYQENKLILQDVSSSILSPILNYFYSGKIEINLENVVEILFFSSKYLIDELIEISSNFIKNNLQFETIVDILKLSETMNFNQLIDSSYKFILDNFDEFIKTLFFLELEENHLNLILSNDEILTNEFELFQTIIKWGKHKSNINQEKKTQKLDKNEKEKLQIQILNIIDKIRFIDFSKKELKDTLKKDLIPNQISQKLIEFQKLEKNQKNQKKLKQFIEEENSLIFKSRDKIKFQSSILNETEHFKKLKEWINDDEFFSKMKKGYSAKKDGFNSQNWHKAVDDKGKTLVIIKTKDNFIFGGFTQVGWTTDKSKWSSNANDYGWIIDSNAFIFSLRNDKGDRNPEKFGIKKEKRNMLFADIAINSQLEHGWTDFGHCYNLPKGITFGTDESKSYLAGSPNQWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH30</accession>
    <name>A0A9Q0LH30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH30"/>
    <dbReference type="OMA" id="IVELECR"/>
    <dbReference type="OrthoDB" id="9997817at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="242"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="677" mass="81058" checksum="D3C436843D2B587D" modified="2023-09-13" version="1">MGNDEIILNQQRSFRKIEKETRPKQKLRKIQIEKFYSKKLIIKKENQNGNKKTILNEKDFKEILDFNEFLMFTNEIQNKNQNENQNENQNKIENKNQNQNQNENKNQIEIENKNQIENQNKIENENENENKNQNQNEIENKNENQNENENQNENQNQNKIENKNQNENQNENQIENKNQIENKIENEDENEDENEDENEDEVEIEVEIPVEVDLTQIEEFIPIFQHHIRYTLIKSNYKKEIKRKSVAEEFLETEKSYVKFLKFLVYQFMNPMVEKGIITPDQRKQIFDGIDIIYSYNKRLKQNIKSVVQNWNTNSCFGKIINGMVKFFAIYSSYVNNFDVSTKTTRTLRKKNKKFSEYLARNTENEKCQNLEFESILIMPVQRLPLYVLLLEQLLKYTPLEHPDFEQTQIALKEMKKVTEKVNETKRIFESQGMLKKINKILTKHSKKAIDLQLVEPARRFMLVQNFELVNQKEKRKFYQIYVFNDSILFCTSNSTKSGRESVQKNGEQIPKNLNARYFVPFSDLVRVDVEYEMDIIDKTAKRNEFINRNNIINQEINTNKNPSLEIEKITTNSKSKIKKKNPNTQKDSNLIIKRALNQIHQLSLHTFRTQAQRFMESNDLFTIEFKLKDKRKEKLTFKAISKEERDLFVNDIHSFIEIWKNWISNDLGNKSKRNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIC2</accession>
    <name>A0A9Q0LIC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIC2"/>
    <dbReference type="OMA" id="CICENFA"/>
    <dbReference type="OrthoDB" id="15111at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="39"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="171"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="253"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="328" mass="37059" checksum="15A4AB1275F943AF" modified="2023-09-13" version="1">MKQCPNNQKIQENGCFILQKFANKNEDNRNKLKNLKGIKCVIKSMNNFPNNQDIQYKGCGALQNIGVNNENQIEIRNLKGIEPIIKSMNNFPNNQDIQENGCGALMNIAANNNESRIEIKNLKGIELIIKAMNNFPNNQDIQYCGCGALQNIAANDENKIEIRNLKGIEPIIKSMNNFPNNQDIQENGCGALKNISFNNENKIEIRNLKGIEPIIKSMNNFPNNQDIQKYGCGALQNIAANNNENEIEIRNLKGIEPIIKAMNNFPNNQDIQYKGCGALQNISFNDENQIEIRNLNGIESIKKAMNNFPNNQKIQENGKWALGRLQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIF5</accession>
    <name>A0A9Q0LIF5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIF5"/>
    <dbReference type="OMA" id="DWRVRRN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
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    </feature>
    <feature type="repeat" description="ANK" evidence="1">
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            <begin position="440"/>
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            <begin position="474"/>
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        <location>
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        </location>
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        <location>
            <begin position="917"/>
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        <location>
            <begin position="1167"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1274" mass="148183" checksum="749E3B83ACA603B6" modified="2023-09-13" version="1">MNQSTEQLLKHYLNQFINQNINQNTNQNINQNTKQLKQVYEAIKTNNIQFFNSILTLKTTQQFEKENKPFLNYAFKNKSKQEIIQKLIEKETNLNWIDKNKNNSLHSALSNKYPNEIIELLISKGSNLNSKNNENEIPLHIALKNKYPNEIIELLISKESDINSKNKLNEIPLHIALENKNPNEIIKLLISKNSNINSKNKWNEIPLHIALKNKYPNEIIKLLISKGSNINSKNKWNEIPLHIALKNKNSNEIIELLISKESDINSKNNKNEIPLHIALKNKNSNEIIELLISNGSDINSKNNKNEIPLHIALKKKYTNEIIELLISKGSNINSKNNQNEISLHIALKNKYSNEIIELLISKGSDINSKNNGNEIPLHIALKNKYSNEIIELLISKESDINSKNKLNEIPLHIALKNKYSNEIIELLISKGSDINSKNNENEIPLHFALENKYPNQIIELLISKDSNINSKNNWNEIPLHIALKNKYSNEIIELLISKGSDINSKNNKNEIPLHIALKNKNSNEIIELLISKGSGINSKNNWNEIPLHIALKNKYSNEIIKLLISKCSNLNLKMDRNEIPLHFALKNKYPKEIIELLISKGSNLNSKNKWNKDTPLHIALKNKYSNEIIELLISKGSDINSKNNWKEIPLHFALKNKNSNEIIELLISKGSDINSKNNQNEIPLHIALKNQYSNEIIELLISKGSNLNLKMDRNEIPLHFALKNQYPNEIIELLISKGSDINSKNYENEIPLHIALKNKNSNEIIELLISKGSDINSKNNQNEIPLHIALKNKYLNEIIELLIFKGSNLNLKMDRNEIPLHFALKNKYPNEIIELLISKGSNLNLKMDRNEIPLHFALKNQYTNEIIELLISKESDINSKNYENEIPLHIALKNKYPNEIIKLLISKESDINSKNYQNEIPLHIALKNKYSNEIIELLISKGSNINSKNNENETPLHIALKNNLNEIIILLIRDLNIFELKENEINQEIIDLFPKIYSFNDDLNNFLKSNEFKDIEIKSNDGEIIKAHNQILLIRFNNNQKILTRFINICRRKSKEIIQFSLNFLYTGFIDFDKFIQKFNNQFNQNQTKIDSNFQFLFSNQIEFENQKKEEELILNEIEKQNEEFQKGIIYDLFEETGFDLKWIKEKEGIKGILKDFEEFYQENETKDFTIIIEEKEIKVHKLILEIRSELFKGMFLNVNDLSNQVHEYSRKSFETIQQLIYFFYNDKIDETKLTKENISEFIDLKEFYQLNQKSILGSYLLDFYSKSLSNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIR4</accession>
    <name>A0A9Q0LIR4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fluoride export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10526049at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
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            <begin position="93"/>
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            <begin position="122"/>
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            <begin position="250"/>
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            <begin position="284"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="563" mass="65542" checksum="543974151C347755" modified="2023-09-13" version="1">MTSLGILNANEKDLTQIEEAHEDQPLLSKHSKKINEFEYEDPYELTFCGFYVSKKTYLKIWQYVWLFIVGCFACAFEFWLPDLYFSDVNLTNSFKNAFGSFIISLTGQIAQIKFQYPQTYLMYNAIQGAFCSVFTTFGNIIEDTEETLYFTERWFSPTLLFGNIIVSVAFNFLGRFVANKIKKGVKYSSALMKMDNEDKRMLYEIGVRLWKQDEITAKKNPNRIKEKNKKKIKKRKNINKKDPPQLVIFSELSSTSTTTTTTTEEEKDISTEKSTEKSTEKSNQKSNQNSNQNSNQKSNQNSNQNSTESEVFQLQGSDDDIFDINEPKIPYDPRINAPRQMQKLQKEKNKKKTNGFSFYLHNVAGNTDIHELADHIENQIEKRSRHKTLELKRRHKVILFVLAFFAAINFVLARFPLYYPAKSITTPSLSVFYYGITLMWSVSGAFSGNFLKRDLNKNASVQWGTFKTNIISSILIATAHNILMFRLYFSNSFKFYLLVSTFISGFCGSESSWAGLIDETVILFVSDIPKKYAFRNIFYNLFLCFFFYLVLSYFVRFFLFFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ07</accession>
    <name>A0A9Q0LJ07_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040487762" evidence="2">
        <location>
            <begin position="21"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="697" mass="78914" checksum="7502038725907E9E" modified="2023-09-13" version="1">MNFGLLFFLSFACFFLLIQTQFNETNSLNLPLGIDWVTSSFLDEDAGFLYFLDQRNTDETYLWKYDMNTLDILNYTEIGVDCYGEYGAIDTVNKLLYVAKYYSGSQFFKIDLNTMQVVDNITLTVPSGNHAVRVEIDVVNQKAYVGYQNPIYVVKVDLASFTEGSNLTLSNDKMTGSVIDVDNGILYVSTDSNSGNNATIYKIDLSTFTQVDSLLVSLSGVAYLKCGVIDSTNQMMYFGTNQWPTKIVKINSADFTSVGSVTTTLGGDCYGAGIDETNGFAYFLNSYYIYKLTLASFTVTGSVDFDSFWLDSMVLDSSAGNAYITSGLAQVIQVNLPSLTEGNKSNSIVYTDPEFIFIDEPNQIAYIYFENLGGIISKIDLQSFSLVDYLIIELNESMDYGEIDTTNGFIYLFPYHEDLDIIKIRLSNFTFDGIVTVATDTSIYGTSFDSQNQVLYVEIYNDTESEYYLAKITCPDLQIIDSLLLDNLNVYKMHLDSSHGYLYILLKNNSASSSKYFIFQYQTSPLNQIGSVDLTQYYVSKSVLDKTHQFIYFGDYDYDVYYYFIYRVDLVTMQVMSGSLYTESEDLYGSFMSPNDDWVYFVVDYYNSDTDEYEGAILQIEASSNQLISNTTFDSEFLYGYLYASDQSKNYGYLLDYYSTPVTLYQLPFGDLPPSSSQQILFSFLIFGIMILILGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJH1</accession>
    <name>A0A9Q0LJH1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJH1"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039190">
        <property type="entry name" value="TTC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="465" mass="54733" checksum="4672001B90CB802E" modified="2023-09-13" version="1">MNQNSNSNHFNFSLFTLPERKKGNQNPKQEMKTKRRIKKETPQPFKGIDIRNFIPNFETKKKQLESLDDVIFEFKNLLNEKTEEEKEEDKPIQEIDDSMFFLRPFEDYYALNFGITLNPQIRIFSILKKGMIVGAKIIEIARDYFIAILNCFFGRKSDEIILCDLEELGIKTVCKAWEINDILFEQYQKFGQFNHTFEKHSKKYLQEFLINDFIKAIVIEVSVEEKKVLLSLRNRNLLVSFQKNHYLGRISSRHVKLLKNSSNDFLNQNFLVHLNNEPGFKNPSLKSCDSSFIPKIKNLLFIENFEAGRYENLRLQQNRIWATETVSQGVVLAKKGDIQSALNMYQKALDVDPENSDALVAQGAAFANQNKMQIAINSFKKALEIDPEHQNAKRYLEITRKRLALQLNSLIPQNYFEKNHKKIKKEKSKKKSKKRRTNKEKKKKKKKKKKSHKKNKSKKKLEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKJ1</accession>
    <name>A0A9Q0LKJ1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKJ1"/>
    <dbReference type="OMA" id="IQKQRIM"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="7">
        <location>
            <begin position="227"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="4">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="355"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="380"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="442"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="667" mass="78455" checksum="4D27A3986F725BE5" modified="2023-09-13" version="1">MNPLNNSPNQNNQQNNSLNSNQISQIEEFKLLKKTYFPKKKSTKKKTKSKKRYEPTIYSRPDSIFETKLQGLLAEKDQVEQTKILNEENSLENEIDIGVEKNIVLLLIQANQQKYISGELHLTNYRLYFKPINSNIKDKSILKRIPNVPLGFLSKVQKMGGQKKSKGKFSYGIEIFCKDLRSYKFAFERRNHSRREMFQKIIGISFIPNLNFCFAFTHKGDKVVDFGWAIYDPFKEFKRQGIYENVSSLWTVSEFNKKYQICDSYPEILVLPTSVSFSQIKEVAKFRTKKRIPVLTWKCPQNSSVLCRSSQPRIGLSKKTNRQDESLLQTISEINTLGQKLKIFDCRPKANAVANRAKGGGFENSEGYSEFKIQFLGIDNIHVMRDSLNKLFHSSFYSFVDDKKWMTSIEDSNWLHHIQKILYWSIRVSKTILDNHSVLVHCSDGWDRTSQICACCQLMVDPYYRTLEGFIVLIEKDWLSFGHKFSQRMGHVGKKATDNQRSPIFVQWIDAVYQIWKQFPNFFEFNEALLIVILEHCFSLRFGTFLGNNDKERNQQFCVKESTYSLWTFVYHNHQMFYNPFYTPSKEPLYPNYSLRSLCFWERYYLKNFVKDDENSSNETILDITQTCRNLQKEVDELTNKIKKMKKQNSKTKKSIQNLQNQIKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKK6</accession>
    <name>A0A9Q0LKK6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKK6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13397">
        <property type="entry name" value="ASKHA_NBD_actin_Arp-T1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="393" mass="45212" checksum="3B7A6EA51B3D02DA" modified="2023-09-13" version="1">MYLNFESIDQYDYSNQYDSVIKIVIDNGSGMIKAGIAGEETPKYDFPSIIGKEKNLKKETKSTDKFYIGNEAFLKREILSIQYPIQRGIIQDWENIEKIWNHVLFNELKIFPEQTPVLLTEPPFNPNRNREKMIEIMFETFNIPYSYIAIQGILSLYAAGRTTGIVLDIGDGVAHSVPIYEGYTFPHAISRMNLAGRDLTDYLMKILNEKEYQFTTTSERETVKDIKEKLCYVAEDFDKEIKNSTQSNSIQENFQLPDGKFIKIGNERFICPEVLFNPSLIGMEHQGIHQMIHNSISKCDQDVTKDLYSNIVLSGGSSLFPGIETRTQSEIEKLIEPSMRVNVFRDFSEVSGRKNMVWIGGSILASLIPFKDMWISRKNYLEFGSLIVHKKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKU1</accession>
    <name>A0A9Q0LKU1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von willebrand factor a domain-containing protein 5a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKU1"/>
    <dbReference type="OMA" id="YSSMPCP"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="266"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="847" mass="95799" checksum="80E730D9CC73B983" modified="2023-09-13" version="1">MVRIGLVNNKTSNTVPLKGISVNCEIFGFTASVTLNQRYENEENNPIETVFVFPLDSESAVCGFEVFLEGKHIIGKVKEKQKAREIYDDAIAQGKTAAKMEEEKPDVFVTNVGNLGAKKQCVVTIRYVTILSEEPDGRYRFFLPTTIAPRYVPVEHIEESQQTDLANVEYSQKVPYGYTINISMEMQSKITNVTSPTHEINPILNSKYCTVSLQPSEKEVGKDIVVLVQEEYPHEPRVVTREDKEGEVVAMATLFPDLSELDVNSEMIFLLDRSGSMSGSPINSVKKTLEIFLHSLPESCFFNIYGFGSTFEKLFPESVMYDDNSLSQAKAHALDLKADLGGTELIGVLREIFRSSARKGFSRQVFLLTDGEVWDTQNCLDIVKRNRGSTRVFTFGIGHGASKELVEGIARAGGGQAEFIVENEEIKSKVLRQLRLALQPCLSNTKIEWKDIKAPELVTPWRLPPIFSLSRFLIFMFFDKKEVEEQRNQNQAKSPTLILSALSGNKEFSWELPLSFDESIRQPNALHPLAAKWMIREMTEKTSKFHNDQGSLLQGITQEFIDKEIIRLGTTYQIVSSKTSFVATVENEDESENIEEIVVRKIPVQKPVEKPVQSARQYSPKSFSLSYSLRKPSPSHMIQDTMDDAIFDEDDEDIEDEVNQVLEEIYSEVGLSLNALTPINSLSKAEEKEDEMDNLEYRLSLLKSDGSPPIREKSVSPEPVIKHINQNKSTNQSPIIIVTDSEKSILPPKNLSVVESIIYLQKANGSWDLTEELSSQISLSTEKIRKEIPENISENVWITAIVVFYLETKHSSVQDEWFLVVEKARKWLKKNSSINLENLIQKAKNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKX3</accession>
    <name>A0A9Q0LKX3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-related rab5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKX3"/>
    <dbReference type="OMA" id="MVCEYIL"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="209" mass="24059" checksum="23C523600B2C95AB" modified="2023-09-13" version="1">MSLIKTYQFKVVLIGESGVGKSCLVIRLTKDIFQPFHISTIGSSFYTKIFSFKEDEEIKLEIWDTAGQERYNSLTRMYFRDAVGAICVYDITNKDTFFEVKKRIQELKSESLDITILLIGNKIDLESQRKVKYEEAAEYAEENGFLFYETSAKSGEIIGESFKALASLLNKNNQDIHQKINYKNNQKSKKEDNIDINLNQKPQKSGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL25</accession>
    <name>A0A9Q0LL25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microtubule-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL25"/>
    <dbReference type="OrthoDB" id="10691666at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="669" mass="78938" checksum="07118CB26C4DE4C2" modified="2023-09-13" version="1">MNLNPEIDLENFNEQEKNEDQEDPLQNEEFYEQNSDFFDDPKLNQLIFGSLENPLFDSSTSRNLKRKSNENLSPDEKTPGKRLKKLINTRIGSNKLTGYQYTQIVLENINRPSTRAEITEKAKELFPDLWKCYEEIFGTKQGHIIFGSFLLRHNHSSITFHPKQRVYSLTKWYSKIEDLDFYSDFNENENLNIQNENENLNIQNENQNENENQNENEIQNEIQNLNQIQLQNIQNENQNQIQNENENENEVNEEYRIQAEKEAKKERLKKEKMKKAAEKWIESQDLSEVKGGPSKITQILTKKLPNRKKGWEYASEALKELGKPSTRSEILQKAKEKNNKLWECYVEAYGEKKAHHPFGSFLLHSKRSSVVRYDKHYHLYYLQEWEINNLEEYFQQQNNNKTYKQKLQELLVKNCPNRQPGWFYVVETLKYIGRPATRKEVIGFARKIHPEIYSCYANVYHPNGRHSAFAQFGRFLISKNSIGKKFLFDPNSKLLYLKNTENQSVDSSNENSADLYYDQQRGFIDSIVDDQPTMNYQENYQLHGESPFDSNLIETNDPILPDSLLNPNQHDLIEDSENENFGNEIYSDGQSDFHLFQTPVISHIPLRSDLIDQNSLPKQKLESDFQFEKNDLKNDLKNDSKDEKKINEDDSILENEMNLNQTPFDFFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL64</accession>
    <name>A0A9Q0LL64_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL64"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="895" mass="102897" checksum="26E025712E92BF6C" modified="2023-09-13" version="1">MEEKFSFDKAISNLFESNSFYDVTFIVGSNQDKETFYCHKLILSLRSEYWQKLFFGANWKEVQDKDCKIEIPDIRPSIFQEMMRYIYCNQVKINSDNLLDIFICADKYLINGLRETCEDDLINSLDSQNCLDLFHFSESYNLEALSGKIIQFIIKTIDEVLKIHNLSQKLSFNFVLQIISSVPIKNQFDILCSFFQTQNDGLKSNQDSSEALPKLTQEQIFQIDEIIDFRFMAHEQLKELKQLGFLTKKFERILEEKNQEENIPIYENLICRLEVNDLTFSNDGIWKDKSGFGNNVQKHPKYELPTVFNVENYNGKSFKVMRFKPSCGMIFPDKMIIQQPFTIMIVDRYCGSNKGRTLQSRYLNWLLGKWSGHNGCFMEGWIGKQAAHNDVFSINTCVSESNQAKWYLDGILQAVMLSPKDPYRLGICGGGKYSSEVSDADIAEILIWNRKLSGKELKKMHSWLGNKFGVNQPNMTNQSLVVSVSGESGIENGEWKDESGFGFHAQKHPNCELPKVYNVENYNGKSFKVMRFKPSCGMIFPDNLVIQQPFTVMIVDRYYGAKRERTLQSRDLNWLLGKWGGVNGCFMEGWIGQFSAFENEFTINTATLSNNQPKWYFNGKLSGDNGGISSPYRLGICGGGKYNNEVSDADIAEILIWNYVLSDEEREKQEKLLSQKYGIQLQNEKERDMETQSLIVSVSGESGIENGEWKDESGFGFHAQKHPSYELPKVYNVENYNGKSFKVMRFKSSCGMIFPDKLVIEKPFTIMIVDRYYGAKRGRTLQSRDLNWLLGKWSGKNGCFMEGWIGNEPVSRNDFTINTATLSKNEPKWYLNGELLGITGGSTSPYRLGICRGGKFNNEVSDADIAEILIWNYVLSDEEREKQEKLLSQKYGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLE1</accession>
    <name>A0A9Q0LLE1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_08964</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLE1"/>
    <dbReference type="OMA" id="AHNWLFT"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040125465" description="alpha-amylase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="16">
        <location>
            <begin position="31"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5073280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="457" mass="51938" checksum="02B022D7D526F43D" modified="2023-09-13" version="1">MLQKVFLVLFFFSIVFSHSASEWKQSRVIYQLLTDRFAKTTGNTGSCADLSNYCGGTFQGIINHLDYIKGMGFNAIWISPIPKNTEGGYHGYWQQDIYEVNPHFGSADDLTNLIKAAHDKGIWVMGDVVANHVGNVDMDFAAITPFNTSDSYHSKCQIVDWNNQWQVENCRLCNLPDLAQENAFVKTTLLNWVHDIVQNYGFDGLRIDTTQEVPKDFWTLYSQSAGVYTVGEIYNGDVGYVAGYQGCIDATLSYPLYFTLISVFANKQSMYQIQSEYEAYASNFPDMSILGTFIDNHDQPRFLDLNGDYTSYKNAIAFVLMAEGIPIIYYGTEQGFAGASDPNNREDLWRSGYNENSELYQYIKQINEFRTSSKFDNTQKQIQRYADDNFYAFTRGTVFAAFTNKGTNGQVSRLITYHPYSDGTKLCNLFDLSDCFVVNNGQFTINLNGLPKIYYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLH9</accession>
    <name>A0A9Q0LLH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLH9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="104" mass="12438" checksum="8C75E5B661FAEEC9" modified="2023-09-13" version="1">MSLCDAFADPWHVSKSIRKRIAKIITRFLAQQRKKKKQKRGKTNKKRRAQKEKDKYLESVLLFHHFDTKVVKSGDIPFSLKLKNQYKSGFLLKPFYLMCPFYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM58</accession>
    <name>A0A9Q0LM58_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM58"/>
    <dbReference type="OMA" id="LDSSMCL"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="258" mass="28822" checksum="5A5875AA3D7DFF0B" modified="2023-09-13" version="1">MMEFGHPLNTLTGHELGVISLAVSKQAEYIFSSSFDGTLRKWDLKNNTTPTIIELENSYQPWMLDINGGDEVLLCGRDNGKLDLFGTQTNKLMRTLDSDAKFLLSAKFSPNGKLIGCGAENGIVTIFDVETGEYFAKFEAHAMGIRSLCFSQDSLLLLTTSEDGQVRLFDYHHSDTPINTISAHKSWVLTSAFHPSAPIFATGSSDKSVKVWDIRNFENLHFFDSHKDQVCDICFDPLGQQLVSVSDDQSICFYRLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN44</accession>
    <name>A0A9Q0LN44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN44"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="50590" checksum="750E2E86106EEE16" modified="2023-09-13" version="1">MKSNSKSNSKSSEEEKNQSKKRSEKIEEEIKNKKRQNGEEEKELEIENENENKNENENINLIENENEIENENINEDESIYKEIKPKPAKVQIFSNFEISQLNQDLFITAISFDQWKYLESEFSHSSTFYKKEEPKKPEIQKSTFPEEFCLSIFTFLNENNREYQNKEIVENNYKKGKVNFNCVDAKNKNNLEIKINWEKLEIFDLDSQSKRSSLNFHEYQFLVNKHSPNQALALFLRYNKLQNLLLEFSNEKSSQLFIEVVHCYFKHYLERARKKNQNVQLFYKSFFYDPNINKDSIQKFKKFVQFNKKLVSICFAVKKDSQEVPSYFQIHKNIFKLFLDGILLAKENIKNVDLAITENSPKDILFSTRKGNFVLRFGSILLKDFVSEMFIQFQNELSQNPEIPQSLKAPIPKYDLNFSNITDIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN50</accession>
    <name>A0A9Q0LN50_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Proline-serine-threonine phosphatase interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_06724</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN50"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="295"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5075862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="353" mass="40004" checksum="E529972CBF12A0F0" modified="2023-09-13" version="1">MSFRNELIDYYEPTKEMVSTNLKELKELTELLQKIAKLQEFYGHSLSKLLKGAKVGNKSTGTIKNAIEVLKTEYQQIGDAHENIAKTTLNEISKSLIEVTKSIKQSKKSIASTSDKQGKVVQNLKKKYESSQSKLTKVDSELNSIQGDNPKAEKLKTTKSKLEEEVSQNKRNYDSNQTEFTDKVVPGVMDKFEECEKNRIQGIQKGLELLSSMNSTKLLEPFQESMRKVNQAISSINLQTDIQAFIQNAQSGKSSEFKSEKKSKTTTTNTTNTTTTKRIEGFNVSKTNQKPQAKSNTFKVRAIYDYQAEDETQIDLKVNQIIVVSNTEDENWWIGKIGSKEGYFPSNYVERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNI1</accession>
    <name>A0A9Q0LNI1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNI1"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="153"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="492"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="627" mass="73526" checksum="4CC8E92CEC8F5EA8" modified="2023-09-13" version="1">MNDCLFFGINEFPKLIKNEPDKIKKPIQFKFENENENENENEKQIKQISLSYYSTIFLFKNGKAIEFFTDQEYSNQNPKEIQIKENIQKVTVSVQNEAILTKEGNVFAKGRDINSNNSNQFINISSLIEDINDRVIEDIVSGDNSIYLLTSNQNVYEIGSNQYGQLGFDSETLEKTEKPILMMKNVSKIFSGNFSNHVFLLNSNQELFGCGDNRNGQLGLGESIKETKIYKLTKIQNIPKGKIIDIQCASWHSIMLIEDENENENLKRKLYSCGFYRFNGLGIFHNAYEFTEIKSSLFEDDDNILDFSVGRNHNLILTSNSKLIGFGDNAYGELGIEDGYFELSPIQIELPKLRFNENISNYHISCGFRKSFLYYSPSSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNNSKINLKLYSEIKEIINSNEKIEETIKRIYLNENENENEKDFIIEREEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKDIINEIQIGIDYFQLNQTNPNLFDLLINKFNNQNSKLKLKLKLKLFNFLKEIIMKLKEELIIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNR2</accession>
    <name>A0A9Q0LNR2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inactive non-canonical poly(A) RNA polymerase protein trf4-2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_06601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNR2"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="77"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="267"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="523"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="573" mass="67301" checksum="09CDDB9ED38AE442" modified="2023-09-13" version="1">MQNKQNNKQVNPTKQELPTKEEKKKNEREEEKKEKNGRKGNQKKNERDRRWKKREIRNKRYGAYKPDPRNIGGKVHGEIMEFVKKYEPNKRDDSRRNYIVTRIKEVIYEVLDRAEVVVYGSFASGTYLPDSDIDITVLVENVSTPQQIIYVLEKHFLDTVADHGFQVIQTLPFARVPLVKIKDKNSGIQVDISCNVLTCFQSVQFTKQAIELYPPLLPLLLVLKQFLRVNQYNEPFYGGISSFTLLLLIVSFLQFHPVFNQQRQKTDLGSLLLDFFYFYSTFDFYHLGISVLHGGLYFYKPSSTYYIPNQPEIPVIVDPLNEAHNTSNSSFAISKICLAFRFATTLLLKRSPLFSLLFRKLTPQNFPNLFSFQNQIENPNPNQLENNLENQNQLKNNLENQLENQNQNQNQNQNQNQNQNQIENQIQIKIQNHLENNLENQLENQIQNQNTQSINYFSDLQNKNFRSEPYIISTPKLRYYYYSLLSPIPQKQIPFQNTQNRINPSRLNLSSSQDDKLLKSFPYKIKPQKSSKNHKQQNFINQNKKKNSKKKNKNKNKNKNKNSAKKSKEINSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP08</accession>
    <name>A0A9Q0LP08_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP08"/>
    <dbReference type="OMA" id="IENCNIA"/>
    <dbReference type="OrthoDB" id="18598at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="872"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="898" mass="103698" checksum="C0E45D827F1965F1" modified="2023-09-13" version="1">MAAPSMKVITVEDRIKVVNLMKSKNEKLRFLTWIREKNEKNKIQDRLVVITKYRVFTLVKKQESKLKIDRNENFFNLKELLSLNNLHCCIVFRDFFIDCYSDQSDQLCISLLKSYLTISQGLSKDLMLEFKSEPENRLGPFDLKPKIAEGFIQMYKCWCNFYQTNVSYEFISYLSNDIVQNEDPETSINFDLSSYPLFNSLISSQKDLVPIVETLKYNQYFKTLTCLNIPNRDLIPQLSESLYENCSLTKIILTGTNSPNGLDSIGKALEKNQEIKISFLDLSNNKIVDSTIKNGFGMGIEKNSGKLQYLDLSSCGMTPKITEKILGHLSKSTNQNMQYLNLSENQFKKQGSQGFSSWLKSATNKKNLQEVYLSNCGIDFEIISSALLQSSAECTLRIVNLSDNKMIQNHGSALCNFVRENRTLQELNLTGVMIPPQIASQLVFEVLVNENYSGFILHLGNNSLGPKGARLISDSFGQLPDSKSLEELILDDNKFSVEGMSNLFKDYEKGIFVNKSLKRLSISRNVEKTKSQKLNTDAIVNLFRHPTLEYLRIRGNIRYALSTKLKEVFPKIKQLNLIALDIKGNEMGPESIKNLADLISKRSTKLLSLQMDSNQFNLSAIQSIAWSFKTNILLFDFRWPKHDISKMFYGLSSKEKKKLKKNIKDLKEKITTGCNNNNAGADMPQISPDVYDMRIFKSGNVQDSDLQEVFMSDFERLSRNANTSETTSSELEDHKLRKQQSDAFIPKFQKNPIFKSRKYREKRNAQKMKPQEIKNLFNQKLNLNQNQNQNQNQNENQNQNQNQNQNQNENQNENQNQIKNENLNQNETQNQNENQNQIKNENLNQNQNQNQNQNQNQNQNQNEIQNQNENQNQNQNENQNENLNQNQNENLNQNQNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPC5</accession>
    <name>A0A9Q0LPC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPC5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="303" mass="36615" checksum="E4E8C4EBC534DDAE" modified="2023-09-13" version="1">MIFRDLRNFQYIKSSTQINSSTENIRKELDKFTNKTKIKVNNFKERLILIYLDLFNDPEQSNSLHLLSNQKIIKFQQYFKNVYPELQMYVLFELKKIIIDNDEKTLKFFQENNGWKVLFSDYFIRTKINHLNKNEMNTNLQTLLLNFTFSTISKYQNYFDYQILSNQFIQNNTIISNLTLLNKFLEMNLEIIKFNRQISANKFISYFPFETVKNIIFKIDNKNKKGKEIDQTIKLYLNFLDQLFQNGSIETIYEIPQIINFLFEPTLFSFIQEIALTHIPIFFEKTKNFLNKVNFLFLIYFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPK0</accession>
    <name>A0A9Q0LPK0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G protein alpha i subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_06222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPK0"/>
    <dbReference type="OMA" id="DVKHYIM"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003800">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="171"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="265"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5076642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="349" mass="40625" checksum="B212F464407AD9DA" modified="2023-09-13" version="1">MGSKSSKRRKNKRTQIIEEQLRTDSLKKSQQIKVIVLGAGDSGKTTLLKQMKIVFQGGIPEHDKKFFRDTIRANIINNMLTLLRAAEDLDVHLSEENEKIAQFFFSSFIGDSDSLTETARDQVYQLWSDSQLKQVFEERSKFQIADQAGYFFDEVKRIADPDYIPTNQDILNCRIPTTGVNVVEFHLNNYHWQVVDVGGQRSERRKWIHHFDDVSVIIFVVALSEYNQRLFEDVSVNRMHESLSLFNKTTNSEYFRSKNCIILFNKLDLFARKIKEVPLNQYFPEYHGDNNVESGKEFFKQKFLTIGSNHQRHIFAHFTCAIDTEGMKLVLESVNLCIIENFLKDQGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ92</accession>
    <name>A0A9Q0LQ92_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ92"/>
    <dbReference type="OMA" id="NMSWLRE"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="127" mass="13865" checksum="8C5E79D918EB2058" modified="2023-09-13" version="1">MTSDDLYAGMTALHHAAKRGNEEDDFGLTPLHWAAYGGHTGCVWLLLDKGADIYARAKNGDTALHKAAWRGNKATVQHLLEWGADVTVKNDESKIPMDLARETEIAAMLQPEMPDDGDSDDDAELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQA1</accession>
    <name>A0A9Q0LQA1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA replication atp-dependent helicase/nuclease DNA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_00088</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQA1"/>
    <dbReference type="OMA" id="NYCEAAI"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5076771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="989" mass="115015" checksum="415CFAC902B196B3" modified="2023-09-13" version="1">MLKQIEEEFLIVKKISLYKQLKILQTITPNSKTKFNIILKGKWTELNISEEDHIKITIDEKSKMKENEDSITISNETNSISVNPEIFINMTDICSGSWCLRKSVLSSVFIPFHSVQAVQLMQTGEIAHEIFEHCLLKTSQNSQKNANQTNQILFDVFDEEIQKKSVNILLSEETISQMKTKLNKFIFNYLQWKKKYMDNYGKIKVARMKYRRQQQEFFWKVDSLVSVEEKINSLSYGFVGKIDSVVKSTFSEVDPKIIMQNPELDQQKKKKLLEPKITPLEYKNSEKPVQNSQIEQVQLYLKMLSEKYNSEVDHGILHYFKKSIYDNTVAVLFDQSIFSDLLFRRNLIALHRIRNTLPKIDTSIARSCAKCQFARFCAIYDLLQSGTEKNHDKFYPTNFLTNQDLQFLKIWNLFLDKESTQSYLLNQEIWTQPLEERIRLGLTIGDLELIESDQIQNNNENENENENENFIETKEFWNYKFRRLSQNWIPQKFIKGAYIALVSLVSNPQINAKKSIHPKIICEARIISITNTLVEIETENQIPLLLSVENDTQNKPTFRIDVSFSISNHKIQRTNIFQFVVKNNKIRQILFQDAPHLLGNLDNQTDISGIPLSLPQTANSVEKAKLILDELQSTNYIIISGLPGTGKTHLAANIAQEILKRNSTVLVVSSSKFGLKRILGKFVEDQVSHNDILSFVKMSSSTEEMEKYYLNYKFEETEINSQEDLKKFQLKIQNFPIVALTVKEIYHSLLVTEEIRFDYCIIDDANELNVPSSLGPLVMAHKFILLGHSSKNPPSILSSYSNSEIEMYSPSLLEILEKNVKRNSIQLKSQFVVNQEIMDLANSLNDDENQMVCFDQEISQSVLKPNTQDEPKKHDNPKLEISHFLEQKVLSKIINPENPVIFISMNRDFLQNAKKSNDFPEIEDSFPSYNQPKESIKPDDPMHDFNRTFNSFNFNRNLQQTNWIHFFNNRTTKHFLPSKKLLLFEFNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQB0</accession>
    <name>A0A9Q0LQB0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQB0"/>
    <dbReference type="OMA" id="ECEWPAS"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="3">
        <location>
            <begin position="248"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="488" mass="58310" checksum="426611A216BE3F79" modified="2023-09-13" version="1">MRNNSRKISQNNTFVLTIILLLVSIFVTFFLFNFLINDTKYLDQFPKLEQNNHKEIIIKELIHVQNSIFKIEKEIEELKNENESLNNFTSNASFYFEFDFDLLNYTDPYLFFDNESNRFNHYTNYNKSLEYQKQIISQNQINYQFFYGSFALNLPHFLNKKAYQIFIKHRHQKKFEQIFDEKNQKMIFNSSVNSFGNITYFKDYSFQIFPNCTPYGIKNNVDFEIPNSNNIKHMEKVVVAIAQFSYAFQHFIDRVLGSLIRIRPFIKDKGWTLLIDSNTHEIPYQLLNLIKEDFNVKLEVYDPSITYKIDKLMIICNIPFIHPRKFQEIRAFLVKNILKINSNEEAPIYKQENIIYLPRVNTINERNVINNEEVENYLRKRFGNELKIFSHKEHQNLKELVEYFSKAKIIIGAHGGAFYNLLFSLSHPIIIEFQGENTKGELSLFYWISHTTGNEYWIDYIEESGNDLIINLDHLKEILNNVLKENYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQS2</accession>
    <name>A0A9Q0LQS2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQS2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="26"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="23681" checksum="517D13AC0F25527F" modified="2023-09-13" version="1">MKPVFDQYQMEIELRKNFPQFSDSEIIKDIEYVKKLQEWINDNDFFSKMKKGFSAKKDGFNSQNWHKAVDGKGKTLIIIKTKQNFIFGGFTQVGFKHSQYGESINDSNAFIFSLRNDKGDRIPAKFTIKQGQEGNAIYSNLNYGPFFGYSYPDFHLNSNLQPGWSNFGKSYNPPNGITYNTDSGKSYLAGSYNSWVVDEFETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR95</accession>
    <name>A0A9Q0LR95_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR95"/>
    <dbReference type="OMA" id="NYSVYFT"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056326">
        <property type="entry name" value="ISD11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23511">
        <property type="entry name" value="Microp_apicomplexa_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="112" mass="13677" checksum="308359E88D509838" modified="2023-09-13" version="1">MSIVLQKNLKKHITSNLKTIIFGFATKYEIESLLKETLEEAKKFNNYNFKEYFTRRTNEVFDEFWKTNEKDESKIQQFYDERKQELEVLKRQTKIDNLYSTKKFVIDSDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSC5</accession>
    <name>A0A9Q0LSC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSC5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="346" mass="42734" checksum="523FE1C9CBBCCFB3" modified="2023-09-13" version="1">MEKEKLNKNQFENQNQFENQNQFENQNQFENQFENQFENQNQNKFQNKNKFQNQNQFQNQNKFQNQNQFQNQNQFQNKNQFQNQNQFENQNQFENQFENQNQFENQFENQNQFENQNQFENQNQFENQNKNQFENQFENQNQFQNQFQNQNQFENQNQNQNQFENQNQFQNQFQNQNKNKNKNQFENQFENQFQNKFKKKKKIFNCKIEANDGTNTIQLTFSTPRELESLTGLNKKDLEEIEQFMKRIGTVHLFYKCKSSKNSIINEETKIILNWKKKKVERFIVFCQVDYLENQKKKQNETSNEFLFKTKKNLNTLILVQKYPVIALEIIPVEDYLIEIERYIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTI4</accession>
    <name>A0A9Q0LTI4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sap30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_03980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTI4"/>
    <dbReference type="OrthoDB" id="10573170at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="8">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5079671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="85" mass="9977" checksum="B2A247084D10083A" modified="2023-09-13" version="1">MGRISKNGNPKEKKSKYSKSHVTKVNFSKLDSHTLQNLKKYYRIKTDKNISYQELAVKIAEKFSQQKVNEDEVIRNFLMVVKTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU52</accession>
    <name>A0A9Q0LU52_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000041">
        <property type="protein sequence ID" value="KAJ5079082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU52"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="114" mass="12860" checksum="F51FA15A8F97FCAC" modified="2023-09-13" version="1">MCLNPPHKCLPFEPSRGSHLPAFSGWFPLLEEGICCLAVSWAGYCLFSLVLNVKMQRSILSSTRSSIAFFVPPFSSSGRSRMMKLVYAKSLSKAYNFAFFFLQMKSLSLKTKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUK0</accession>
    <name>A0A9Q0LUK0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lim zinc finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUK0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="299"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5078784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="496" mass="57712" checksum="838328C62B85F85D" modified="2023-09-13" version="1">MLKFLKRKKVLCPVCNSPIKSTEKIEVDGIKAHKKCFVCKVCNVKLESSNYKFVNHSFYCNSHAPDTSTLNKQGNEKTKQTKMDSKTTQSPSEKEIKLKKPKNPSPNTTKIKYPLEQLQKKHNTPNNNTTQEAKPMNTKAEKYKSFLVKPTLKAQDIQTLQSIAKKHTQKPRTVPKSPKLALKNPNYTTNKSPNNPDIQNDTKITDDFSNSKPKTQVKKIKKITKIKKNKNQEVEKVKNNLDNIFNEPEEEKGKSIQKSKENQNQNLKENENIDLDLNLDSSSLSDLDNQDSFVDSFANETLSSVNKTLTDEIERLSTENKKFEQAKKEKQKELEELIQKEVLLDREMEKIEDQKQNLILQIEEKKKQFEKKKEEKEKENQKFTEELAIIRIQNKKLLQEIEALKNQNQNNQEIDSANQILKQEIENLIKQNNLISEENLLFKEKNTQITQINSIIQTLGNENKRLIQEKEKTVKNEMQWICFLQMKNQNLILMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV19</accession>
    <name>A0A9Q0LV19_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000034">
        <property type="protein sequence ID" value="KAJ5079186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV19"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="126" mass="14843" checksum="C3BE730F62CC4688" modified="2023-09-13" version="1">MSTKTNLKSIHLQIRNYIENDKESTCLYLIKIIGIICKKKHSSCIHTMKNGWSFSYLWECFMNSCKNNLFSFSPFFLVSFGHNNSNTFNDLSYFSDFPSLKIDKDEEQKKTKEKKKKKKQFTSQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV38</accession>
    <name>A0A9Q0LV38_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV38"/>
    <dbReference type="OMA" id="RYKFEAW"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="84" mass="9758" checksum="EADF30320172C841" modified="2023-09-13" version="1">MEEQFKTAAEEVKKLPKKPTDKELLKLYGLYKQVVVGDVNTSKPGVFSPKERAKWDSWNSFKGTSKDDAMKQYIDLVEELKKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVF7</accession>
    <name>A0A9Q0LVF7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000024">
        <property type="protein sequence ID" value="KAJ5079627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVF7"/>
    <dbReference type="OrthoDB" id="409642at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="92"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="584" mass="70001" checksum="928F09BF517340B6" modified="2023-09-13" version="1">MEYFTEEKEKELKIDILKQFYISKSKKEFNIKQTIISLLKHKEIKEKQKTSQNKRKNESKPKTKNELQKLKEFLIKKHQKQILSIFNKKKTSDIQIYCGIDKRILYCHKSILTARSLTFLTKIFEKQQTKLIFNNFHSNIVTPIMEYIYSGELSFNKEEFDKYWEFANQNKLNDVKKQIELEMKEYLQLDNIANIYFKSQNISSRFLIEKCEEFIIPNIQQIIQRFDFKNSQLEQNISFVGLISLHQSIQNKFQLLQLFQQKWKENTQENIYKLLQKQKKEGLNRNSLIKLNQNETINSQEKEEYFDNDKFFSILFTQIQQTQTFTFQQFQKIKKRYTHNFDAKIGSLNKRISKKFEEYQGKKQILIGKELQKSKIELDIKKELKEKEKLEIYQSSDKAKIYFEKLKNSIQENDKDETKELLQIDIALFFICMKNFPNNEYIQENCCLALRKFTDKRKRISFNLPNLKGFNLIIKAMNNFPFNRFLQLQSILIIINIGKENENKTQIETNSGIDTIITTMVNFTKDKEIYNKGIEALGVLGLDKKEIVEKIIQEKLKRLNEEYRKSKPGEKVHFFINSFQNIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVP5</accession>
    <name>A0A9Q0LVP5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVP5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="68" mass="8432" checksum="0F84A49CEE816EFD" modified="2023-09-13" version="1">MKQNFAQESLHDNRSWFALFIISTKSKICDNILDEHKTKKEQTNYDEEQYIERQQRRRKITKTKKEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVT1</accession>
    <name>A0A9Q0LVT1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rh50 isoform b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVT1"/>
    <dbReference type="OMA" id="IHVFATY"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF60">
        <property type="entry name" value="RH50, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="14"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="453" mass="51157" checksum="0880055BE4192242" modified="2023-09-13" version="1">MIKKNRYSSSFITFLLIFEIGIFFAFGFWFDYDSSYYPETTENDPRVEKYFTFFSDTTVLALMGFGFLLVYLRNYCYSASGFSFLLVAFAFQWNLLVYAFFYQMHIDIFGKFKLDIETLGRGIYGSLCALISFGAFLGTTQPTQILMIIFIEIFFYQLNYYINIFKLQAFDMGGSIYLHEFAGIFGYAVTLGLGSRKDIKKHPDIKSRYNSDIFSIFGTMWLWIAWPSFNAMFSPTGFQFRSLLNTIMAISSSVIAAFAVSIGVRGKFHMREIRNATLTGGIAIAAASHLKMSLVGSMICGIIAGALTSFLSAILTKSFRVFYGGEQIRRILFFHAIPGIIGGFASAFGAGLADEDKEPYKDHYHEFFPRGDVQYGAQLAAMGITLLIALISGYLTGLIINEITFRNTQPLNDSEYWHVPDDFEETTIDSLGIPRDHKGNVVGDEWVLEAEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW22</accession>
    <name>A0A9Q0LW22_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterile20-like kinase isoform b-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW22"/>
    <dbReference type="OMA" id="AHHENIV"/>
    <dbReference type="OrthoDB" id="98077at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="288" mass="33829" checksum="444B67E515EC225F" modified="2023-09-13" version="1">MEKNYYIQPKDIQIDEIYKRGATGKIYAGTFKNQKVVIKIFERSCKEFRNEILILTHLQNKAHHENIVEMIGYHETSNGKQFLELSHSLESTNFIVLEFVSGGSLFDKYHQLRTKKQKISEEKITQYAKDIASGMKFIHELNIIHCDLKSWNLLITEDDRIQICDFGFAISNQKIEQNFDEQNTSLFGCWNPPESLNNFQQNQFTQKTDVFHYGLLLFEMVSLQQPNSFYSKLKKFYQSEKNQNNVLFDLVSNDAGSCNKEILQIMVQCFQKDPEKRPTFEDIVNKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWE7</accession>
    <name>A0A9Q0LWE7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWE7"/>
    <dbReference type="OrthoDB" id="10251692at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="719"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="831"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="940" mass="109193" checksum="DB9B0E905320CC9E" modified="2023-09-13" version="1">MEIFDRNFLKNQFPQIKSLDKQILLSKNFESKNLLHIACTITNPEPELIKFLIEIGVPINNLDNYSNPPIYYLLSNKKRFNEKIADLMISSGADLSLVPDCLLFALNAKCSLNLLKRIVSSKVNVSLPILQKAIGMRCRFDILIFMIQKTQKLDIFLLLQLLNIPPTSEAIKIVELIQKNSSESNFLSSDSGNQNNQKDNTNKTIEENQIIANLDLNSFKKIIEEKQNKKSEFGINLEDNVKKDFIIAIYIFKLIYERKLKKQWRTYSRYFVTPLYVVSKNPNTPPEVIQFCIKYGADVLEETSRQKNCVHGFCGSGNSNLETLLVMIPSENSLKNKLINKRSISQSLPIHILCKHPKKELYEIFKFLLENGTELNVFNQGGFTPLFTTFSYDPDIEIIELLFKHGSQLHLQRVRLECGLYYAFSSHNIRFEILDYLVDKCPDINHSKQQNDPILCKVLESSCSQKEYFLKKMVEKGVDVNLKNIEEEIALQKACKKPYSVDILRILSNENTDFAQITRYGHNNLLHLLVEHPCELDAIKFLLEKGLDINSKNNLGKTPLHIACENSLFEEMKNLISLGADIRIKSNYQRTPLDSIPNSSNFPKMVELLISDCYDISDFPGNSETFLQSLLYIKKIHQSILQKLFQIGVPFDISKFRDFAERLLKSKQHQLLKFLLGYFPMRNIDSFANITHPKNKIILKSYCTIQEDMEYLLVRQEFTDISIDFLDGKISVHSIILRNRLINNISNAEYFEQVTNRLRTFAIKHSKDEGLVLLKFIYSGRIPLENFSLVWKFLKKFVKHMQFSQKWISEKFGKSQLVSDLEVLYQDDSTKDFTILVEEKPLLVHKVILLARSELFREMFLNVNDSSGSVSDYSGKTFDALEELIRFFYLDDFSSKHISKEITNQLFDAHDFYQLNKNSYLNILLMETNQKYQQFLKRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZ50</accession>
    <name>A0A9Q0LZ50_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZ50"/>
    <dbReference type="OMA" id="GIVHQKC"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="378" mass="43364" checksum="4DDC6719FC5D2D82" modified="2023-09-13" version="1">MFDEDEIQAIVLDNGSFEIRTGFAGDDAPRTVTSSVIGEKLNQYDNYSTSSKTEYIGNEAQKNREILNLNYPIQRGIVEDWDNMEKIWNDIFANQIKINPNQHPILMINPPFNPKSHREKTTQIMFETFDIPAFYIANSGVLSLYSSGRTTGIVVDIGHGVTLTQTIYEGYEIPKGIDRYDISGFDLTNFLIKLLEERGYSFTTSNEIEMAREIKEKLCYCSINYEEEIKQNQNQFNLEKEYELKNGDIISVSEERIKCCEGLFQPRLMGIDLEGIHKIIYNSIMESDIDARRDFIGNIVLSGGSTFFPKFSDRLENELKALFPQQARVKLVAPPERKYSPWIGGSILASLSTFHGMWISKEEYDEVGPNIIDQKCYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4T7</accession>
    <name>A0A9Q0R4T7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000141">
        <property type="protein sequence ID" value="KAJ5066538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4T7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="257" mass="30540" checksum="6861161774CA125D" modified="2023-09-13" version="1">MNQNDKNYHHKLNQNPFHNPFHNPFHNSNQNQNQNQNQNQNQNSNQNQNQNQNQVMNQFQNWIQKSFQDLLQNSFQNLNQNQNLNQNPFQSSFQSPFQSSFQSPSPIQIQTPSTIQIQTSSPRLSRIPSQNQNLVRSNFPLKNSFPDFFENENENENEIEIENKSRSVDLFRDESENESENDNQNQLESFKFQNEPPLLFPNSFESEKENHNELEFPFKFQNQNQKSNSNSKIKNLKIKNQNQNQKSKIKIKIKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5Z1</accession>
    <name>A0A9Q0R5Z1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bud site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5Z1"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="921" mass="108983" checksum="8FF7E3B2A71317EB" modified="2023-09-13" version="1">MSQSLSFTHECEEQNLGEGLLSRQIQLKITKFGFGPPDFCHVMKTRLNFKNQSKKKSKPNVVFGFYHTVIGVDTSNIASIASYFGRLLSSQENPSKNKEKWVIISGTFCSYNPFSKLDLHVQFSLPGNLIYYFVDENGYKLDLKENFSPKFGLISSPLIKINKKKKKNSLFKEKNQNQKKNNENQEKNQNQNQNQNENQNKNQNQNQNENQNQNENQNQNQNQNQNENQNQNQNQNQNQNQIENQNQNQNQNQNQNQNQNQNQNQNENQNQEKNQNQNQIENQNKNQIEEKNIENQDNTKDTDKNLWNETYISSLFRSIHAHQINIYDQIPIINVVDDIFHTENETYLFKLFKIFFWKGKKLGCSKPRNLVSNTNNYFVECLVNYFSWNFKFTKGINLFQEFLEEDPEIAVPLSKLYRKIKEYNKALKVLIESYNIIPNSIPLLSILIKTLIKLNKNNKAFKLASHLVSVAPYFPKAYILLAKAQLREKDYSGVFMSLNNIPFHTNNNNSTPYSKMDLLTMFPKPERVIFPNTPKHKVNKDFLQAKFSQNNKNNKIKNDNQKDDNKEISELPSRKLENSLEKNIYRILIAFSINYGWEKMMQCRINVFERNNYNLYSIKKHHKKSHFGEKIIYKPDEIPKYELFENNNENNNNENNNNENNENNNNENNNENNENNNNNNFAEKYWQIHELDFDCDISSQTENESGNEKQNKNSKLKYLRMNIQDKFPAPLTQIISDNSKINYQQWLDNLIQFLYYDLKYFNNFLLEEEKAKQKPDFLKEKYSYQELELIGDLAYRLKNFRASKNCYLLNIQITGNKVKKKNLQVFTKLMKLNLKRGLMADVIIIANRILFFLSSKILSFEEEFQAKNAIRFCVFKLIFQYGFSPIDFFIQQRFNKDQPIHPNFNLLLQEAKKKNIDGSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6N0</accession>
    <name>A0A9Q0R6N0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6N0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3638" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="927" mass="110124" checksum="23123F8F96001192" modified="2023-09-13" version="1">MGEGKTKVIGPILAFLQSKIFQDKKPLLIFLTPESLIETNSQDMKITSKYSFNQKLNLLQFSRNEENIEKENLKNILEMFKKCKENYEFIISTAESIQCLELEYISLIDEFEKWEEYKKNQNQNQNQISKTKKQKEEEEKKQEIPEKIQILNQILEIIKKESILTIDEVDNVLSVFRNVNFTTGEKDLKFKDYQIEIIKTIYKKYGNELKEEKNTILTSKEMKQKQKIIVENILEILIPEQVDNQTYEKYFDYLMNEISLSKKDFEKQKDPNLSEKLSWSRYILNDLLPQVIDKQPNEHFGISKEKWKFEEKNSKQIHVAIPYKAANKPIEGSIFANIFETLCKTIHYYYYIGLPSNKIQHFLSFLQREYKQLASENSNKHSKLKKQIQKEFKIDISEVRIDQLSKPKLEEIQKIVNKNLFNPKVYAYSHFHQYIKEEILEQFGCESRQLNSTSSDLCSFFQLIVGYSGTSQTKERDQSLGRVVNSLLQIEDKNIFIIQPKKTPLQLFEEIFKKNENNFPFQTFIDVGAYFKGFTNTEIAKEMMIFFSKHKKEKEKEEKETETKTEIKIKGILFFDEKDFLSIIKENEEENDFNLKFQVIKIGRSDPKTIQTITQLNQEEIFTFYDQSHTIGADIQQPLFCEALLSISEKTQTVQLLQGAMRMRKLNYGTQKISFIIPQPTSIFIKSTLSLSEEENNKNNNNNNNNNKNNKNNNNNKNNKNNKNNENDPKVIKFKMKKLTEKFEKIQTKISKIEKEIKSFENSNQKEKEIKSFENSNKKKKKLIKKKNKTEKKIDKLKPKSIDIISFTFINDLKQFSLISIHEIIQEINTIIKSEIFEWILEIKELEKKRKLFKLFGKEGEIFIKQNIQDYWKQYSKKTEMEDSKEIIKNLFNSKNNKLKIYLNKLQMKFQNLNQKEIKSKKEFWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6R4</accession>
    <name>A0A9Q0R6R4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-k</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6R4"/>
    <dbReference type="OMA" id="NPQAQHV"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="38"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="150"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="403" mass="47774" checksum="EC7C22C8F3E9ECB9" modified="2023-09-13" version="1">MSKYGRWFFTREEVQEHSPSANFMSWEQEMATRQKTTAFIQSLGLSLEIQQFTIATAIVYFHRFFTLRSFEQFSRIDVAIACVFLAAKVEETPKKLEDVISNSYLLLFNRKIQISEANKEYTNFRDKILFSERVILQTFGFDLSIDHAYDPLLSFLRRIEADNDTAQVAWNFVNDSLHTILCLLYPPKIIAAAALILATHYLERSYPDPYELFDVSKEEIDPIRKEIIQSLQTKDSQSNSHTDSDPIQMDILNKIRSELKEEDQSKFMKQENLNKNEKQNENEKQNENEKQNENEIQNQNQNQNENEKQNEIEKQNQNQNEIQNQNNNENENQNQNENQNQNQNNNENQNQNQNQNQNENENEKQNENEKQNEIENQNQIQNENQNGNNQNQIQNFEEKRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6W5</accession>
    <name>A0A9Q0R6W5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6W5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="395" mass="47506" checksum="01BAD7A5BEE2B27B" modified="2023-09-13" version="1">MFQKDIKNTETKEQETKREKKKEKKTIYLFINPSFINQQEKTIKIIFKNQNQNFEMNQFKELNSSIWYFDIFDKINQDSIFQFQIIPKNQNQNQNQNIDEIERNISKNENKNIFFEFGSEKISSKAKVNFLDILISFNNKSSKTPKILSQFKNNINLLQIDESIIKDFFDSYSNYETENDKSKILKMLFLMKKEYIPDIITKILSTKLEIIYDKLIKSQLKDIFQSLFEKISTDSNISEDIIIQYLPIFIYYNLKVIEETNEDIEKSNESFKKLLTFFFFENKNEDERKSKFNLLIPSIDTYLSITKQSYQILLKILNKLFNNLNEIPHQFFIKIIDKMQSQINQIDNIEQFIDIWKPLSSLFIQNDSEEQKEQEQQKNNNKKKLFLFLKNILIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6Y9</accession>
    <name>A0A9Q0R6Y9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sca1 complex scaffold protein scaa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6Y9"/>
    <dbReference type="OrthoDB" id="17150at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037474">
        <property type="entry name" value="ScaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516:SF1">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1195" mass="142538" checksum="8CA5FD0B80985C52" modified="2023-09-13" version="1">MSYQKRSYSLVEKMLDIKSIRNKEEIEKNKRILRTEFNYPYELPQIIQEEQKELKFSQNPKSFLPIYLDSKGNVYNLYFEKLDLKEIFASFENEKSKFNHKIIKNFPKLNRPSPKFPDDLNFKDFSDFETALINWKKDMLTYIGFAKIPKIIGRAYERPQVDLKKVLDQTSEQQRKIEKKMKTQSVSIKHFPSLLSPKPKVQFRETISEIIDFHLPTNFTKISWDQELIPEEPDPENYKTFEEFEIAFQKWSQIIMNTTSLIPPHAINFVDMFGLITNKEKQRREFQTKEKEKKRRLKEKLSENNETITHPNLYLNWILKVNQFVVLNSLNIQDFEKKIFSKSNFVELKENDDQNKFEINNFHRQESEKIVLLKKTQSMMRIIPTKEEFEENQKTEKEEKEIEDFEPKQNLLNGNTIDQINQFIDSVISLQNRNLTKYQQFHSAILGICHGFFSKSSKDQQNKFDNFNQYLRRKDISMKLINESVDSPDNIVGKEVTFAIPKYELSTPFTIKELQTNQKSLRNEVINLDKEHNENNLMAWNHPVSLPTELAKFQELILKLESFDLDIFLKFFTQFIYLDRFEQLLWEKKMYLNNKSVMEYIAQCFTSENFKELLKLLNYSPSILFQSKVSLFIKIFFLFPKSIEIFKTYLDSYQMEEIYHITFAFNFLAKNSFQLFPCVHVFQNFDLVKSNIKYSILERDIFFHYYLKILYQLIQSQRRYSFDSISRILKEKVNYLDASIQTGIDMNKDYFDHVFKFICSNSIHNSAYYLFILMQLLEIESQTFLGQLQSESIGLFQKLTNPQNSKFTTVKLAYHQIWKKLLTLPNWKFFLLSQYSKRTQLLISELKSIIENNNKNNSSLIVELIKCYLKNILESSDQKNETEINISIPLKIFELLKESISVKRKKNGITEIAEILSLFIKLFMKQKLIHFESIVNKKSKKENKWIVTTQFLQEMINLTTEKYEKDEIKTFLFASIRFILRTNQSSNPNLIFPNQENFYSSIISSIQENKKVTIAQQMWGVFTDCVIYQPGSISFFIQNDLFKSLFETLSPLNYINSIYAMKTMVKIMNLVSKESERISQNKFPRRSQKNSLQSFQKDQKIFYRFMEKNLLILKIHLIYTECFLKNKEGQLFTNLGHVYEGFFKSKKMVKLMKNGPNKHMFEEEILLMSRVLGYDNLGKNNQKQKRKKHQKSKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R746</accession>
    <name>A0A9Q0R746_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R746"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="18597" checksum="5AE5F661C52D5656" modified="2023-09-13" version="1">MTSLWGKRPEHSTGNSSPSQNKPQNGTTGLTLFSNKNPNTPTQNTKPGLFSSNFKNLPQQSPIRQNYIIFCKTRRSCFWAITPANRTNSQHVNEQTMSQPSQMEVSKTQDLFAKKQTHNLFANFSLSQNNPPNSSFFAKRDQNQNQNQPKTSIFSNQNQNQKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8N4</accession>
    <name>A0A9Q0R8N4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8N4"/>
    <dbReference type="OrthoDB" id="2311693at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030140">
        <property type="term" value="C:trans-Golgi network transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23211:SF0">
        <property type="entry name" value="TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23211">
        <property type="entry name" value="TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN TGN38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="63"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="368"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="783" mass="92375" checksum="9C8C018B4C9DCB65" modified="2023-09-13" version="1">MENKNNNINNNDNKENNQINNNDNDNNNNNNNLITINQQFQTEFNQNLIQNYQNLLKSNQNYSDITIKIGYNLKEFYCHKSILSCQSPFFSLYLKENQINEITFTEISEEDMNQIIQYIYTGNIQLNQSNLFSIWLISIKFQLQSLQNFIENEIIIKNFNQQYFFQFFENQNLSINLNQQCNQFIQNNFHIILNNPKFKELKKESIFKIIEITQKTKIQIDFIPLFDNLEKWILNQFKKKKKFRTKKKQNYKQKQKQQMNLSKEKKRIMQSFLDKINILSFKLGPDQIKQFQSKIEFIPKEIFSHLISGQKDKEIQESLKKKDKEIHQKDVEIKEILKQKDEEMKEMKPIYEISRKEIEKSNLMKESKIIQNFKDAIYIKEFISNNEFFNSMKLGFSGTRNGFSNQLFHQKCDGKNHTLVIIKSKNGFIFGGFTQIGFFSSGGWNISDPNAFIYTLKNPKNYLPSKFQYQNGKCIYHNPNYSIYFGSGGCISIKDLSTKKGRSYGYANKNFEFPEGVEPKEAPIFFTGKPKWEIEEIEVFFKPQSNLNQNQNYNQKSIQNQFSNQFQNQYQIQNQIQNQYQIQNQIQNQNQNQNQYGNQQSQNYNQKSKSISSYSFSNSDSNDSDSDSDSDSSTKSGNEIQKINEKTTTRKTKSISPRRIPNERNYPNKISKQKSNQNQNQIQNESKSDSETKSKSKSESKSDSETKSKKKHESKHESKHESKSKSKSKSKNQFQNINQNQNQNQNQNQNQNQNQNQNKSKSKSKSKSKPKPKPKPKPKPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8S4</accession>
    <name>A0A9Q0R8S4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">purine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_10396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8S4"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="910"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="9">
        <location>
            <begin position="332"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="9">
        <location>
            <begin position="691"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="933" mass="104560" checksum="B8FAD3CBB6793C74" modified="2023-09-13" version="1">MIERIKISEYNQKLLSAVNIIKERIGEGDIGMVLGSGLGSLADTIENVKEIPYSEIPGMPQTSVSSHKGCLIGGKLKGKNVLCLSGRVHEYEGYSDHELTYGIRLLGLCGCKILIITNAAGGCGEGMEPGSIMAITDHIFPSKTNLLTDSFIDPILGEELPNLSDVYSSRLLNIARGTYLLSPGPAFETAEEVQSGIRGGATAFGMSTIVEVLAAKKLGMEVFGFSHISNIAAGISKKKLKHEDITEQIETSGPRMCKFVKEFVSRITFLEQEKEKFEEKKLDMKYENIYIPPYYKPPPPKYEHIREAGDYIRKKILALPKVCLFVSCYHEMENIESHFSIQQTISLKKIPFMPIISPSAHFAHLFFGHTRKNRVPGCLVFSKDFRGFYEGELSFLVLLFRELGVNFMIQTFIASGINQNENQEQKDVMIIDDIVNYHLTGIQCNDNEINQKVKKTAFVLNNDLKSQFEKIANNDKLNIFRGVFSTGMTPMYLTNNGFKFQSVSGVDAFGMESLDGFLTARNFDVKFLGIANVVYYQKDIKIVTEKLISQNAHKSASKFMKCLIDMIDSQVETNLPEKQSFVEQKTQIPLDNQEKTPKKEAKKSLLATEFPPEPIYDQGVYGHVEKIKSTLSKLLNGLKIELAILIENGVEEFKNVLTLKNFKRTKTIPLSEIANLVSPDYKLEDDFHDDNNGFVVFGEFLNVGVMLIYPGSNEPHSKTSIHDVVIVLRLAHLFSVKSLFLLCELCSVNPELQIGDFVLVKDHTNFSGISPIRGLHDEKWGPMFCDMTTTYSNKSMIEIMNKLKIPVKEVNAMISVDPIYSSVALATPAKNLCGADVISAGQLYQTITITQMEMKAIALGIIHTKIDTEKRVIENLESFEQKNKIEANLREIIEGYIRNRSFQESNFEKIINYTIGATILVSAGIAIRNNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R923</accession>
    <name>A0A9Q0R923_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_10428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R923"/>
    <dbReference type="OMA" id="HNYNESH"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="6">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5071366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="22333" checksum="BC5D1BCD65323CCA" modified="2023-09-13" version="1">MAFREKYIEIGRVALITYGPFTNRTCVIIDVIDQNKVLVDGPSKVNHVPRHAISIKRITLTNLKVKIPHGAKLKTLMKAYEKADIANKWKNSAWGKKLLIRQKRASLSDFGRFKINIKKQEKNKIIKQALEELVQKDKDSAILQKHLPKLEKLKKTKFVPKKRLTRKGKKAQQTKNIEQAKETMDVQIDNQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9G9</accession>
    <name>A0A9Q0R9G9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sca1 complex scaffold protein scaa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17150at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037474">
        <property type="entry name" value="ScaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516:SF1">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1118"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1424" mass="166777" checksum="1B08ECFB44A3DA49" modified="2023-09-13" version="1">MQNIFNENDNEQKKNTNEPDEVKKYFAIMGEYTGPPIKTKEIPTSIREKKAKIQHPFYVGIDGNLFDVNYLPISTRKIHSNEQDFDFSGLDQEQKAKDKEKEISVNNLIDFLCHWEDQPEFLEKFSPKSLEKTPKFPDPDSFHSFKEFELAILSWYQEMEKYIGYIQLPKVISRAYFRPKDKKTLSKKFSETTVTETDFGTETDLNTLSDQISETEYDDSEINTDFVSDDETERTEKSQNSGSDIEFEAEKESRFLVETKISETENKTENKTENKTENKTEDKTENKTENKTENKTENTKNLPQRTETLKISAETLTTEKESLETNHIEFDDENLTDSKEKKKSDSNRDSEKSDSKKQKKEIQLDPDKEYQIYKWIMEGYDLSEIDESQHGIPHAEYFFEKKDPWNSSLIPQEPRPEFYQTLAEYDRAFRRWSQLTVSKLDIIPLHSKQLEAQISLRSFTTETSKKKEEIKKQDFYRNYITWRNGYLKSLNQLAIDYQIRANKFNGKDVFGKNLQESILSVQTKSPQRINEMVQAAFDTILKKSTKLRITKQQNYDFQEKKKTIIRIKKMKISEDEDNNNNNSNSNIDNEKEGFLDIPFELDEAIDLKKIKRNDKYLQQLSTKISTIKFSNKIYRLFSINYPQRIREQVRSKVKRFISDIKYFTIGKIIMFFEIEQFLDDFMEMLKNFEGKIKLRKGLHPFSEIFETIITPSNITEVLDLYDRYQSVFIHAKISIFLIEMIQKIMAKKILENLLRNGDILNLYRIAYGLNYFCEIPSDIFPPMEEIYHSIDMMFGLETKLKEFVQLVQTHYYLKTIYETFEKQHFLIGNLVVINSVIKFIDRETQKIFVSIINLIADQPQIIEKEVFKGLGSSSSRVSVFFLFILTQLLGIKSSELFRILSSTKVNLVFRLGILGASRFVHVQNAAGRIFEIMKTERYINFFATNYAVAPQNLYDDLFSHPKLRHVHRRVSRAGRSHSMLLVEAMKINIPISPDPKAKLARSGTITKKMSAEQGNKETEIITKNRIIEVPSKISELVSGFCRYIYDTLPKKPDLVDIKKTVLANELFVSEFIFKLYLGLQNYHSPSMLELSRLLISMVHFLYKMRLVEGSDIITRSGSRKMSKITANPNAMSPSRDGPKRSQRSISVAFESMSGKLVNKNIDESKEISKVCISYKDIKQLLTIIDNAPQNEYEFKTNILDCVRMLIKEDSVFDLVLKDANFHKTTKDLCALDENLSFSRCSWKMFYQMIYYHEGFCAKLVEQGQLKPLLLSGISKGKKREAHQLKFPSYLPHCLHYVNKLFGMHEIQLRRIKSHGRENAPRAHLKDSVKSLRKDVELVIDLIQKRRLFIHFHFIYTHLAASFPGMPFIELTKIFRLIITSPLYSRLAKEIKKDQNYIKSVEDIQNILSGKERNWNEKQKEKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9J1</accession>
    <name>A0A9Q0R9J1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scratch family transcriptional repressor 1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9J1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="481" mass="57049" checksum="0603D38A9928361F" modified="2023-09-13" version="1">MATDLIGFVVDGIKWFKEQFDNKAKAGKIVIQVLGRIDRLTKTIQFLFPQMKIIPQAKSIDKDDFKTNCDNLQKEMNKTSLNNKKRELVQEKFKDIEISSKKAYLDILIQNQKQEQQINLNQNLSKKQEKEQEKQKNYYQIIISVFYEFLIEDQIKKLENENEKLENNENQNKKFINLTTFLEILKGLFLTVSKYAKKGVFARLTSSSGFLEDIEEQNNLLDQSEHDLNLEVTIKQRVELQEFKKILESTQYSNQNIQPISQNIIINIQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIKNQNQIKNQIKNQNQIKNKNKNKNKIKNENQNKNQNKNENENKIKNENENQNENENENKNENQNENKNENKIKNENQNENENQKNNQPNILDSEKTYSKPKYQSSIINTIQKMFCLNDKRLTTVSDIFGLNDKQYENKSITLIEALNNFKKTSIREKAVKFLRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAM6</accession>
    <name>A0A9Q0RAM6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAM6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="568" mass="67160" checksum="6A6A029EBCF0A8BE" modified="2023-09-13" version="1">MNKESFKNEMIQDKNFIRTEQLIRLLRLSIFMPGLGQDVIIETNNKKKKLYGYSSILSARSPTFAAYKQNKLELEYNYEVVKTALEFIYTSNCEIPIYDPNEKEKTSFDLTCDLLSLAKYWALYEVKFQCEQYIFSELEKKEEVVKSGKDESNQIKNQALKKLNYIDNLNLQIFSDKILCIIDKQMEDIIKNKDYLYISDSNLRMILCRDTLNISREFQILQLINNYITHKFPVQNQNQIQIQNQNQIQIQNQNQIEKEKEKEKENQNKASILLKNDLIKFVRFGTMDFDEFLQIEKLDLLTEEEINDISDFIENKLDGNDSKNQKIIEKYTQKKEIHWFKNERVYFDSNTIISFENEEISKNINPKNADKNEGIADFYSSVIERKKNNKEGWIDEDIFKEMKLQFVSKKEDKLTCKDFHQICDNKAPILVIIESEENIFGGYSSVGWKKPEKQKPSDFYNDNYFDDINYIEDEKAFLFVLRSYKGIQSKIELFPDQKSTSIVYYSQRGPIFGDGWDLAISGNLKTGYSNPGHTYQLPDNIEFNSKEAKMFFTRGFGEWEVNKLEVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAP8</accession>
    <name>A0A9Q0RAP8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein nirf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAP8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040239414" evidence="2">
        <location>
            <begin position="21"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="699" mass="78946" checksum="BC853B9BB4DCC0FA" modified="2023-09-13" version="1">MNFVLLFFISITCFFFLVQSQFNETNSLNFTKGMKTIASSFLDEDEGFLYFLDERDKNGLMYLWKYDMYTLDILNYTDIGITYARYGAIDTVNKLLYVATHYGYQFVKIDLNTMQIIDQIALNDAINNYGVKVEIDLVNQKAYVGYQTPMIVKVDLASFAQESSLTLSNFMLIGSVIDVDNGILYASTDTISGNNATIYKIDLSTFTEVDSLLVNLSGVGKLKCGVIDNTNQMMYFGTYQWPMNIVKINLTDFTSVGSVGTSDGGDCYGAGIDVTNGLGYFLNIYGYLYKLDLATFTIADVLDLNVSMSYTMVIDSSVENSYIGLEYAGVYQVSLPSLTVANRSNSIVYTKPEFILIDEPNQIGYAFFSNSGGILAKVDFESFTLVGYLMMGVYGSDIYQGAIDTTNGFIYLFFDTGNLSIIKIRLSNFSLDGNVAADPDLSGDYITFEQSKQIFYFEYSNKTDHYQYLAKISSPDFQIIASLLLTDMNVYTMDFDFLHGFLYLFYYNYSASGSKKFISKIQASTLSIVGQADLTQYKFEYPVLDQTHQLIYFGHGDEYSYLLICRVNLVNMQVMNDCMNMSLSHFYASFITSSDSWLFLVVDYLNSTSSQYEGVLLQIEASSNQLISNKTINCDLFRSYVYSHDSQTNYGYLLDYYTSETTFYQFSFPPAIPTPPSSSQQILFSFLIFGIMILILGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAR7</accession>
    <name>A0A9Q0RAR7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitinyl hydrolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAR7"/>
    <dbReference type="OrthoDB" id="21192at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF905">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="355" mass="42270" checksum="6069CE0885D8659D" modified="2023-09-13" version="1">MKKKLKEVSFRIHLVELLLTKFNVINAKKFHQLLKTFLYYQNNNFVPKIEIFFKKLLYKFYHHIKLIHFKIREIFGAPDSYTLTQCFSTLFEIEKLKGSNKYFCSFCKRKNDALKMISIKKFPEFLIIHLKRFAFSGNPTEKINNRVIFPLKNLDLSQFAFEKTNVENSYQYNLYSVIVHLGQDRKSGHFITYSKRGEVWFELNDSNVSHVSQETVSESQAYILFYQKIPSEIEERKKYYVFDLIQKNLLIPPLVSISGVWMLKLSDFSNPGRIHNSDLLCKHGNFKYISTQHFPFETEKRITSINENVFEQITSIYGKTFKIESSQDSSQECLECFKEELHKQKNKFKKYFLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAS6</accession>
    <name>A0A9Q0RAS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAS6"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="178" mass="20928" checksum="FF9120D4475BF67D" modified="2023-09-13" version="1">MLIENEDENENQNPKRKLYSCGFYQDNGLDKDEETYKFTEIKSSLFENDDNILDFSVGFTHSLILTKKGKLIGFGYNEFGQLGIGNTQEIQLIPIQIELPKLRFNEEISNYHISCGYHRSFLYYSPLSFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB44</accession>
    <name>A0A9Q0RB44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB44"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="530"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="705" mass="83711" checksum="339E2A1810D5DB02" modified="2023-09-13" version="1">MDKQIFQLIQKAANLQSESKDKEAAENYLLGINYISQYLRVLPLSNKEEARKSLKQQCYLARLCIDNIEKLISNQIENFQPKQNTSNVSNSPNFGRREQLVTTLSQSVGNSNQLQGMQSFGFSQDPEAQKIFQDAQQKNLMLYNFYQSRINSDPSPYMKSSYNLDYLRKVNENFAIARKKFNELMELRKKQNEEKIEKQLINVEIKDTSKNPKKNETLKDLKKKDLLWERSLKQSSKPELQITEHFISISKNPNHPFGRVVIKFIKRHLLDETKISERDLENEKKDIQSFIARAKQYISNNFLILKQTQKFFLKASRDIENYIIEQLFDHIFILYIYKFKEENDNIHNKYETNNDCTLADCGIRKRFWLARNEYFYDQQEKQKQKEKEQQEIENQIEDENQNQNENQDENQNENQDENQNENQYENQNENQYENQNENQNENEIENQNQNQDENQDENQDENQDENQNQNQDENENENENENQNENENENQNENENENQNENENQNENENENENENENENENQSNLQDEQEKEDLIQEQIDRLDDFDFDESQLEQELEDFLAEDEVLDEDEKEPEIDLSLVKSYSNSMEILRTISQKKNASLKVQSLVKAYEAIVEEIRDYYSQFSDVPKSYYEIGADDIVPILIYVVVKANIPNLYSEKQFLEDFISQKDMLGVHGYVISSLEVVIQFLLSQQSKLSLSSLDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC92</accession>
    <name>A0A9Q0RC92_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp20-like chaperones superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC92"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="325"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="530" mass="62842" checksum="90776033C25F663A" modified="2023-09-13" version="1">MILPREYMKTSISHSTSIPNFNEMNEVSFQIDDQTLAPTNYNIPEDYFDFGLDFLHQFNFSSIAIANSISNPFIQTQNVLRFDKNQNFPFFFQNRSQKPFVVQNLNQENQSREEKEMNELQEEIKSYFSSQNEKEIEEIEMKNIFEDPATNLFENETNSEIPKEEETQKITKNQEMKKNESNVYQDATCSFCETAQTSQWRRPPKWFDGEISGKWICNRCYSRLLHEHRSETSRKKRIKKRKTKAKQEKQEKRTKKTQKNNREKQVKRIKKENQNQNQNEKEKENENENQIENEKENQNQIKKTQLKKNANFSSQKRITRSQKKIKTKLFEKPQIIFIQKDSELDPLSLKLKQSVVEIITENGGTVFDQQEIPNVDSTRSTIYLTINEPTLFLNKAPNYQLLLLLILQVPVISYKWIIDSVKSKTLLPQEMYHIFDSKKFTSFKISSVFQKKFRIFGNDIFLRFWNFVIPKLGGFISNNLDNSDVVLYDSPNFPIENQSNFLTKENYLSDFQLVLELQDLFVSKKTQIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCA6</accession>
    <name>A0A9Q0RCA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gata zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCA6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="237" mass="27689" checksum="1312BFC1B789843F" modified="2023-09-13" version="1">MTNINLNENINPNINSNENINLNQNQNENINQNINQNINPNENENQNQNQNQNQNQNINLNQNLNLNQNQNQNQNQNQNQNQNINSDEILFRQSEYLMRKFQPTLFIELISKKLKWVLIPVSITMILVAFFIESIYISGENSNGSPKNKFNSIPVFKSNLNNSTNNFNLNDWGTCFIYCWVEQLTIFLILLNLNVIKILFILVNIVNIWNAFVFLLLLFCIALNYLPTKKNLGKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCC1</accession>
    <name>A0A9Q0RCC1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCC1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="5">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="307" mass="36030" checksum="6DA25E09555AA990" modified="2023-09-13" version="1">MPQFTISSVIGNNIPIEKLFSLLFSDSSQFLLQFHQKAEHSSIKIQKWKNNQREISFSSNTVSSSFLKKFIPTSGITLKETQEYKFKKDEFILYSQITLNLKVFSNIISTKWIFKLNTQNSIQLIIKVSYEVSSWFKNSIEKTIEENTRKELGLWIELAQKELAKESELQSQLLLNIEKNQNKNQNQTQIQQKNELIQILDQLNSKIDKFNQILYSKQENNQLISFNENSNTNDLISFETFQNFEKAVNFNFEKISKIQQSQKNKINSFSLKNNPKEKEVETRTRNLEIIGIIVVGVLGVYYWKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCI9</accession>
    <name>A0A9Q0RCI9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCI9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="382" mass="43447" checksum="0D6B5F623983B2F1" modified="2023-09-13" version="1">MVSILNHINLKELNKAIEEVKQNENDSIKQVNLSFDWLTKGKRQFNAKLFFEKGSQDLFVDNSKMTGGKGNAPNPLDICNFSFAAMFTSTFATLCSLKGILIKKLKIRSTLEFEFLKVTGVDMSKKPINSFSIILSVFSDHNSKEELEEIFELTKKRCPITFMAENSISVTTKTTVQTRTPKKETNTKKINNINMDQVLESRDYLKRNPNESIVPCIIEGEWICDKNEGPQFSALITYGNGKTHKFFTDSRILLGGESSYPFPVQYFLAGISCCLLTHYAYASSLRGFQLEHLSIESQLDENINAEFGLNQNEVIPHLSFHFDVGTDQTVDVAREITEDCILRCPIMCLMLNKINVDTELLVNQSFTHTYEFGNSEKKCFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCJ7</accession>
    <name>A0A9Q0RCJ7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCJ7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="161"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="225"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="278"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="448"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="565" mass="66214" checksum="292A9EF4C60E6808" modified="2023-09-13" version="1">MNEIIFFGQNEYPKLFKNKSYEITKPIQFKFENENENENENENEKQIKQISSSELSTIFLFKNGKAIEYLENSKTKILKKSKLKKIFKKIIEDIVSGAYSIYLLTSNQNVYGIGANYYGQLGFDSETLFNTEKPILMMKNVSKIFSGNNSSHHFFLLNSNQELFGCGYNESGQLGLGESTKEEKKIQKLIKIQNIPKGKIIDIKCADSHSIMLIENENEDENPNRKLYSCGNYQYNGLGKNKNTYEFTEIKSSLFENDDNILDISVGVNHTLILTYKGKLIGFGNNYSGQLGTGDTEDQLIPIQIKLPKLRFNENISNYHVFCGDDSSFLYYSPFSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKKEIEITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFDNQNQKQKSKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDT7</accession>
    <name>A0A9Q0RDT7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btb/poz domain-containing adapter for cul3-mediated rhoa degradation protein family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDT7"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF19">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="339" mass="39795" checksum="4F148BB37A08F0F5" modified="2023-09-13" version="1">MEDEKPKNIEQENTNLNTKPIKINVGGKIFETLTTTLSKWKNSKFEEIITNQKQFPIINDGIIFFDRNPKYFEIILDYLRTSEVTIPKKLNNKEGLSRLIKESKYYSIHSLTQLLNEKIQVLQRQSFTMKEFQSQAYLFQANTPREPSHISQPYIPIMDAGRIERQDLTGLSLTFIRIQNFEFIDCLFGPSTYFNTNFENCKFDGSRFEGVNFHNSKFIDCSFQNVEFVNVELWESLFKTKQNFKGSVFKLCTLNKTNFSKSILDNSSFIDCKIIKCKFSGCEINNICIPEKQFKSNFKGAKVTNLIDISKYKTKIKEVQEWNEVLLDIDKWKQHKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REV4</accession>
    <name>A0A9Q0REV4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REV4"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1155" mass="131705" checksum="74583949B2B10583" modified="2023-09-13" version="1">MSLLYPLHNAISKGTRTEILTFLNSGQNPNELNEQDETPLHIAIKSGNYQAVLLLLHFGADLEIPYRNSETTESLCDFYHQTQIKKLLMTWRNVSRKLLLLDKDQNQNRGFTELHRSIIYGDEPKAKTLVNSFTVHQMTTNGQTALHIAAQSGFLDLCKSLIDHGANPNHQTDNGRTPVHFAASRGEDKCLEYLLSVGADVNTRSTLGETALHISCANGETDCTQMLLQHNADLFVQNYLNEYPLDLAILNGHQACSKLLRFSGAPTNKNGQKQKEQQQQSIVQQSNAELIESVLKNDAENLYKLIEQGYDIRAVTSNGYTPLHIAAQSGSLSSLSLLLSYGADVNAVEKQRRTALHLAAAKGHSDCLGLLLKFKPDLEMKSVDGWTALIFALSNGHTEAAKLLLENGAHKNVVTKDGYSCLGIACKNGHLKCLKLLVKFGADVNERRSNGNSPIQIAAENGHKFICLYLLERKVRVVFAENARHPHVLALFSQDRNLVNILFKEYQRQKTLVEWEEKENIFYSHVHFLVNSVGKTLLERLIRNKKSPDENKLEYENKSGHENKSELENKSELENKSEIENKSEIENKLEIENKFELENKLEIENKSEIENKLEIENKLEIENKLEYENKSEHERRSRNENKSEIENKSEIERRSRNENKSEIGNISQTKPMKISKMRLSEIPHNKIAPLFDSLAKIEQISLQHLKLLVQTRSNPNIQEKVFNRILSQMPKVLSAYKNYFEKFTEYVPNVQLYTNQCAPFGRYLKAKAREISKKDLTIHDLFALPLVRIQIYEQHLQQIYEAAEPFFHPHTTKRLRGMSAFAKNITKDSQYIRNLVTVEDQSLQCSPPRISKHTMDDPTRFFVRQGEAVISVSLVNEQSTNQKHATASKIVLFSNRIYLVQTSPTAHINGTQSVVVVSASTASMWIIPLKDPAMFKILTPKWKAKITVQHPQLAQEWIKSLTLTVTTINNDLLQKMQKVTDLFPKSTKIFRCSVFVLVNRSRVLKMKMFVTSDSLHDAAQLCSHEINQTLKDQRKNKNKNKNKNKNKNKNKNKNKNKNNIKSQAIQDTEQNQNKNKNNKILNINPNLNLDLDLINIPNLSMETQVVRLISSANSNISPSEKNFSKKIFQSEWNTKRIFVSICVSHTIENCSSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REW8</accession>
    <name>A0A9Q0REW8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REW8"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="259"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="478"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="583" mass="68434" checksum="0BFD7A329E703720" modified="2023-09-13" version="1">MNEIIFFGKNKPKLLKNEQEEIKKPIQFKFENENENENEKQIKQISSGYFSTIFLFKNGKAIEYLRNDSNQNPEKIENIQKVTVGFDNEAILTKEGNVFAKGEYINSKKPKEFINISLLIEDKNDRIIEDVVCGAYSIYLLTSNQNVYGIGSNSYGQLGFETERLEKTEKPILMMKNVSKIFSGNFSHHVFLLNPNQELFGCGFNEWGQLGLGESRKERKLYVNKLTKIQNIPKGKIIDIQCGYYHSIMIIDLEEKKKRKLYSCGEYQYNGLGKNDHRNEFTEIKSSLFENDNIIEISVGNDHTLILTSNSKLIGFGRNNDDQLGIEHKNMIISPIQIELPKLRFNENISNYHLSCGFNQTYLYPIILSNLEEDLIKLFGRKEFCDISFKTENGEIIEAHKLILKYRLNQNENQIEIEKLQEIISNKSIKESNQIFEMIYGNPQKRNPKLYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIKITKKIIKEIEIGIDYFQLNQTYPNLFDLLINKFKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2024-05-29" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF13</accession>
    <name>A0A9Q0RF13_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1567" mass="184356" checksum="F2726FDF815BA4BA" modified="2023-09-13" version="1">MESNKKEIFIWLSKISNFEIFPNLPLNNLSILLSYLIQKINSNYSFEINFFDSLSNFSHFIESCKKYGIDQQYLFDPHQENIKEKLLILLNELKNLYEKKKEEIPNKINNFSVLELEKFLSNQLFKLPIRFEFILKSISIENSISSAILIVANLELPKAVIKCYYSSSNYLEILQDPKILFDIKSSLVENISQELNKKFGNEEIFKTTQLFFYLNHQEKSQYIFATSRFKKLSSSESFIQILNSIQPNKSDINQEKELVSVLMEKPFESSKESLIQTLSSSISYEEKIEFNVNIIHVSDGIVPVYGKGNLVFSNMLLQLINEKITKTQVITVGTQVINNNNNNNNNNNNNFQEQNEENSSFLQINFNEFTKWKLQFKSNTLSFIVAKTLEKFIEIQQIAADQLQMKLKLQKKPNIVISRSELAQNDMQTVFLLPEFVDSLTENNKITESWNISIIHDFSLGLSDCDILISLENRNIHGWIQLFSTHFEIFVGEKVIFAQKYSKETKLKINKNNFSQLQLSLRDPDTSLRIETNTKKAGYLLWKIFQMFAFYQGTFVESYQINGRILSEKEEIFAIAFRCWTKNEATFHAYIISNLNIPIPAVIRLTQDNFMIFSQSESPIYFSWSSGHMNFIKSLANPKLLKIKIEETDSGKAIFILCLSKSHCDMLCSTFTSFYQMSLSRIPKLSTKFELVDKFDDPNIFRELVAEFDLYNENFIQSKSLGVSVIQKRTKIDEIVNTPLINYAINVSSYNYSEDLYLTDSIFGYENLNENLNENIDLNENENINYQQINKFCFYVLNINHQIVDIGKISLFRDHFEVTFSNTKISRYYNNFARVTQEQTTPKKCKFVFDELELIYIQFITSKMSKKHSKRFNLLNEQYIQTEKMEKKPENNFLCKFETSIGTQQGEIQLFSRNFYVRSQLDSFSCDYDIHNLISININEPKIREFKYGINSVISVNFETEEIATDFETKFKENRIRLITNSIGKELFSYPVYIEDLSVAGNSRKATIYLTKFQVTIINDNSQIEIYKPNECLIFNEENNKCKIKFGKLLIVIATFSGEQIKRHFINNFRFFGLKDYFSKNTSHFRIKLHSKLDPNAKKALISLTKAYIILISENTEFQYLIKNTELFLHSKIKDLLQIHFIGQNSFIVSFEKPNSKDLFIQMFFQKASNQNSNLRIKEGYESDVEFDEPEQNEQQQQQQNALNIEKNEEDWINKFEVIEIDEKFNQKDNILLSFKDYFLVIQKKEKQEQFLLMLLQFALHPNEKLITRITLPNENNMIFKFLNEEDLHIFRIHFETIYKINQQQKANYHVEVVDENLNHISKGNFILQDKNVIVSYNQENIESIYSEIQVKIHDNYKDVIVFEKKEGEVIFIQFKNWQQAKVVHDLKKDLKDLNKDLKEDLNKDLNKDLNKDLKDDLKDDLKKDLKDDLKDDLKKDLEQEKNINQENQFPVFIFTKNSKIFENAKIVVLNHALLISSQKSENYQFPFSHDTKVNIKSKKDNTLILTFYKINESQCCSPKCCSRSKSILKMLFQDSISKKQFIQIFQLKLNDYYNLDRNQKINEIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF16</accession>
    <name>A0A9Q0RF16_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF16"/>
    <dbReference type="OMA" id="WLEYTHY"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF25">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="798"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="880"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="692"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="753"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="652"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="696"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="993" mass="118781" checksum="B9B88388E284B063" modified="2023-09-13" version="1">MEMDELIQYTINNPFDYNGFIRAIKELTKKSDIQNLNQIRENMNLTFPLTEELWLNWITDEENKQLNEQKYDFNKLVDLYLKALKDCPVNISIWCKYLDFITVSKHLTTENTRKEFEKSLQKVGLHTSEATLVWNKYRKFEEEILDSLIPDNSENVDLKNPVIKKQLEHIGSIYLRQISIPLAGIEDTKNDYVDFADIYSRPDSEIQSIQDSYSKSIEILHSVQEFEMKIYRIITTQDSEIIITFDGENIQENVQKNQELINIWKEYIDFEKNRKSDYDPSRIICLYERALGSSSFSVDLWIEYSQFVNEKLNDFVFLNEILNRALRNCPWTGYLWLQKIRAIEKVLISKLEKNFNSQILDENEFDILFEIVKKKSPKNPEKISNINFLDSIEVEIRQIIEKAFLFGFQTEDEYIQLLYSFIDFCKRIFQAFSQRISKDSTKKKKMSQFIHPQFIRNSYKYILEQLENTQNQILTNRKYYQIEMVKHFAFIERIVLNCYDESKNFWENAIFLSKDQQSQSNQVSILYDWIQFEISHGSYSDSRKLFKRLVPQCTLEFFNSVMSLFLRFERQFGSLNDFEVAEKICNQRLLELNNKQQKIEEKKENQKKKNQNQKKKNQNRKQNQNQNKQQKKNQNQNQNQKKKNQNQKKKNQNQNRKQNQNQNQNENENQNQNQNQNQNQIENENENEIQNENENENQNQNQNQNENQNQNENENENENQNQNQIENQNQNQNQNQIKMNLEENKMDIIQNQDFVPFNSKDQKQTKNEDKKRNQENLENEEFQKIRKVHQENGEKDNKTLFVNNIPFETTEEKLEKLFSQYGKVKEVRFAKKRKENKSSVVFAYIEFENEEMAQKALELDGFKLDGKNIRVAISCPPLKYKVFIDNLPFSATVSSIEKLILQNGCTEVKNIRLGLSQNGKPRGFAFAEFKENQNYNLALSFQNLFLEGRKIIFKKATDQRKNFKKNPKFNMRKKSFQNFSKPKPRKQRINLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF68</accession>
    <name>A0A9Q0RF68_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="7">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="7">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF68"/>
    <dbReference type="OMA" id="KQMIGNR"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="9">
        <location>
            <begin position="29"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="8">
        <location>
            <begin position="297"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="357"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="423" mass="46992" checksum="724907A1F82D150C" modified="2023-09-13" version="1">MLSSLKTKRKVLNQNGNQITFPLFKRLFNLHEYQSKMLMQKYGVNTEKFLVANNPLEAEDAFNKLKVPQVTIKAQVHTGGRGKGTFIENNFKGGIRFCKTANETKDCVKNMIGYRLRTKQSGPEGKLCQKVMVSQTKDIKRELYFAILLDRKTQGPMIVVSPKGGVDIEEVAESSPQYIAKFPIDIKTGPTKDQKQEIARFLEFPPHLWNSAMHEIDRLYDLFIKTDSTQVEINPFVEAVDGEIVSLDAKFNFDDSAEFRQKEIFAWKDDSETDPRELAAKKFDLSYVAMDGNIGCMVNGAGLAMATMDIIKLNGQNPANFLDVGGGAEEEQITEAFKIISSDPKVVKAILVNIFGGIMKCDVVAKGIVSAVKILGLKVPLVVRLEGTNVELGKEIFEKSGLPIISANDLGEAAKKACEVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFC2</accession>
    <name>A0A9Q0RFC2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFC2"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF187">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="81138" checksum="85526B8C3CEEE766" modified="2023-09-13" version="1">MWTRAKDSGKKVIAKYKVNENKEIIEADLSRIGTTKIPTKICEEIIGHQSSIQILDIGYNQISSLEVFNDLIFHLKDLRVLRLNNNFFTNLPKNFVKNLSKLEILDVSNNSLSQINEQSNFPNLTHFYGRNNYWGIFPNCISNSPNVRYIDMRIGQLTNLPKNIENLENLEYLDLSNNALRSVNINLEKLKKLKYLNLSSNKLTQFEISSNDESQLSELDLLYNKFSIFPATILSLKKIKKLDLSFNRLEIPNEIEKLTSLEILRWNSNQIQKIPKNISKLKNNLKEFWLRYNSFYQFPKELLELENITLLDLTGNGLKKLPDEISSKLPNLERIYLAYNNFQKIPNVLKKLQKPLKRIWLDNNPMKKEDKKIVESGMKKLLNYLFPSKKDEKIINNSNIAENQNKEIVKDDSNDSQIKQQKVTRNLDHLKKKEDKKKDEKIIDNSSIAENQNKEIVKDDSNDSQIKQQKVAGNLDHSKKKNMDIDLDEKKKDEKIIDNSNIAENQNKEIVKVDSNDSQIKQQKVAGNLDHSKKKSMDIDLDEKNQKNQSLIVMPQNATKLSIEELKDKIRGTIIGNCIGDAVGLATEFLDKKNSSYFYDFEFFDYEKLVNDGHRSRWIKGDWTDDSDQMLLILDGILENNGKVDEKDFARRLLNWIYNGFRELGDSGGMGLGSTVGAVVSSNEFLDNPHYCAEVVWEKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFM0</accession>
    <name>A0A9Q0RFM0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epithelial membrane protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFM0"/>
    <dbReference type="OrthoDB" id="10631006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="206" mass="23886" checksum="608A966116A2834C" modified="2023-09-13" version="1">MGPRKKIFILFLIPILVGIISIPLPYWCYGKVTVTGQNDSDITTYLGLYSIKFKGEYVNLSNRTDVDETYKLQDMEDKDFVSSNFKSDWKDLNKYYRFALGAVVIAIGLSIIIPFSRRLFLILGWLVFGFFLISILVVVIKTPDIDQMVFESENAIFPIWEDGKIFSSQIISYSYSFFLSCLAALLSLGFYFFGIAIWKKYRKEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFP5</accession>
    <name>A0A9Q0RFP5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFP5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="17999" checksum="BCDA6031A3DCBF28" modified="2023-09-13" version="1">MIYSNNSKINPKLYSEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIQELERGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG79</accession>
    <name>A0A9Q0RG79_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG79"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="349" mass="41565" checksum="4021DC43E4180DC8" modified="2023-09-13" version="1">MDTKKPFNFTIEEQNKHTTSFLFDPPIIFKDFGKNQVDYNVLDDEDPFNIFDSVNPFDFDQYPFDSENPFNFDQYPFDSPNEIGIDGLDFNSHEQPFLPNKKESIQDILFAKDEQKEEENQEKEEIPKFNQINSFEKISYSQALKEITQDQDEQDEQNKIEQIEENQIEQNEQNKENQIEENKIEQIEQIEENKIEQIEKPKRKRRAKRKKQQYEDLNPKRAKKFQLAMKQASKKTNIEGETVVLRRLKEIAKIFGTKFSYIERANKEISINGKLTTWNNLGLEKGDKIVITDSLIYNEGKIRFEKAKNPKPIEKYIENVRHSYLKAFKNHGFQKDNKYEQGKMIFMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG95</accession>
    <name>A0A9Q0RG95_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG95"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="596" mass="69533" checksum="17D048E296D3DFCE" modified="2023-09-13" version="1">MNDCLFFGWNKLPKLIKNEPEKITKPIQFKFENENENEKQIKQISTGELSTIFLFKNGKAIEYLSKNDSKQNPSKIQIEENIQKVSVGSRNEAILTIEGNVFAKGEDINPENPNKFINISSLIEDTTDRIIEDIVSGFNSIYLLTSNQNAYGIGSNQFAQLGFYSRTLKKTQKPILMMKNVSKIFSGNSSECVFLLNSNQELFGSGNNDYGKFGLGESMEEEEIQKLIKIQNIPKGKIIDIQSGDYHSIMLIENENENENPKRKLYSCGFWECNGLGKNETTYEFTEIKSSLFDNDDNILDFSVGYNHTLILTSNSKLIGFGFNNLGQLGTGDTDEIKLNSFQIELPKLRFNEYISNYHISCGYQKSFLYYSPFLSNLEEDLIKLFKRKEFCDISFKTENGEIIEAHKLILKYRLNQNENQIEKLQEIISRKSIKESNQIFEMIYSNNSKINPKLYYEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKIILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQLFEYWIYSNQIKDEIQITQQIIDEIETGIDYFQLNQTYPNLFDLLINKFNNQNQNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGC8</accession>
    <name>A0A9Q0RGC8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000020">
        <property type="protein sequence ID" value="KAJ5079946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGC8"/>
    <dbReference type="OMA" id="DNKHERT"/>
    <dbReference type="OrthoDB" id="16380at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="259" mass="30798" checksum="CDD77FF534804437" modified="2023-09-13" version="1">MEVKYQEYLEKDETLKYEGRLFQPTKEDKPVILVLTNKRLGKIDPKTAKVKFNDLWSIHSIENDAESSYIFQLFVYKKSKSRFLKSATDINSYLKVQSYLCESTEKRTEWVDSFYEALRDFWQQFFEKQYVPEPEIYQVHALLTKFNRKKKKQIRCLVLSTERVFNIGVKLSDMKPSKVRWAIPLSRLEKVLLYRNNLRAFGIQINNTALKKNSQSKMSTIYSFLAKDIEEREMIVQELHILYLNKMGKQVSIEEMGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGZ3</accession>
    <name>A0A9Q0RGZ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear intron maturase 1 -related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000023">
        <property type="protein sequence ID" value="KAJ5079629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="QRNNFQR"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="745"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1323" mass="158367" checksum="D9F4C52F57078585" modified="2023-09-13" version="1">MVKWGNLYVYADSPLISKHVFFDILKPYKIVRGYLRRNKDSTDGHFKVIHDKKARKEQRRTWREGYSITVSKARESYTSKENQLEKLKEKITDRNQRSHKENIEKIIYQTLNSNNFIKNPLIIKKKEIENIQSNQEKHENILNEIKETIQKAIPQMKSKRIIQKDLQEFINKSVNYSYLKTYKQHNPYSYQRTHNLQQEISDSLIQHNWEIDTNLRKTINYRNSKYYMETNFNKILQILDSYKLIIRKSFLNIFEILNIINNFHPLRIIQKGNHQAEIWDRKNNILNLFRDCKNERNRIPRNFKIQLKTTEGNKIETIKGTKLTKINQFSFRIASININGLNKIGKIQKLEKIFLQQRITIAIIQETHLRKRLYFENYHSFEKQGYGTIAQGGIAIIIKKCISKYAQEIKHPDKDIIQIKIGELNIIGVYMRHGTQSQMMSQLNDIIEKLGEERYIIAGDFNQTDKEMEKHFRFNTQIIHNTENSAIRNIDHFCVKNQNREILSQTVNINQEENLSDHKMIVTIEKINILSEERKEYYQPTKQQFQDMIIEKLIKQNLSEKSMLNISIIKNVKEKFKKRSIIHINTKNKIGINLTEFNSKNKYNWKQALRKRWRETMRGIEIDNQSKTNYWTEVKRITKARKDIIFNNNEKEKEFKQLIDKIKIPVQESILQEIENKIINIEPDIRSIKQIFPHDKLIKTIQNSRNSSTCDYDKIEMYQNPYIEREHPKYYEFIKSVNRMMREWIRDPNQEVIKYMLSRRMVFIFKQGDPNQISNYRPISINNALVRIFLKRILEEIEPIWEYISYQQMGFRKMMDTRIAVLELQKKLKEIKEPYIISIDIQKCFDTIDHGLIRKVINKFISNNNIKKLLNEYYKGNGCGIYQGDPLSPLIFGMVSHFIIEEIKIRVDHIQMYADDMILLVKNSYNKVITKVQSILQILENYGLRPNKNKTIITKQKRNVKYLGIILDAKKHIENNIEKCEKTFQKLRFIIQSNQISNHLKIIIYKMTILPQLYYGTEALILRKKQYQKMDLMVNKHMKLILKINFHSPTLTFRNETNTPSSRTQINVRRWKIREKLDKIEKSELKELCPIFTNERERNDKIWENQNLKIIQKYLCLARHQEMSINSGWKTIAYSEITKLEPKKPKIKTYLKYQKSTILMKLRIFTNGLKSYSHHMRNSDVKCPCCGEEEETLDHFFWKCPMYQEIRNKWLKSIHPIKQTIKLMKEISRKGIYDKTIEYIQKAFEIRSEMIMDENIIEIDEENIGNEERNQNENQQQSDMNNENNENNRGWDGIPLGSRISIFGRGCSFVSTNKKLSSKFFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHJ0</accession>
    <name>A0A9Q0RHJ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHJ0"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="426"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="70453" checksum="137736C722B74851" modified="2023-09-13" version="1">MLQKARWIKIGTESKMSPYPRSAHTAIIHNNKLIIFAGRTDDGDMLNDLHSFDFELGQWSRVSINGKLKPTCRAFHSTVIYKSRMYTYGGNYGNSMFAFSFNDSCWEEIPMKGDFPSKVSNLIHNNSHHACVVHQDKMYLFGWKQAWEFDFLTLSWTKLKSAEYGYYSNDIRDYAFSYRGFAYIIHYVEKDLEMTKFDFNTCKFEPIQFKKQGIKFDSNYVVELINNKLFCLSSGQLYSHTFGTDNWNKIEIDPKFEVPLIYNSSLSVHNNRLVLFGGELSTRQYIKDLYELHFGSNLKEDLSQILKSGELFDIEFMDAAGIPHKAHKALVQLRLGSEQEITKFSNLCLHENSIVVTNCLHYIYGCPYEFDMDSFSTNEQTKQMDKIDAAKSTQQLFMQLSRGKHIFEKNEIEKDFLEFQKDNESKDFVIIVKDEDENDVNIRAHKFVLALRSGLYRNMLVSVQDESNTVPDFTGKRPKSIQALVDYFYTDKISHIQNFAKKGDLTVAMELLNAPDFYELTTNDLTFDCLSILKRNLNSDNWFPLLEYIFGERLFEDLEQFIVNFVFYSKFKEKIKRSKMYQKLIKTDWFPMLAKMYRLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHN9</accession>
    <name>A0A9Q0RHN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase trim33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHN9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="52"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="364"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="550" mass="65955" checksum="24038D4DDC3E1478" modified="2023-09-13" version="1">MDNNNNNQIEIQNANQNQNANQNENEMKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNEFLRQESLSISLKQFNKKEMESILSYIYYGNISFENQENLLQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLLKNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNERLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSIPRKVVTRLKQFDFFPKSFLVDIQNKVIQEKDKEIEEKLKKEVKEKLKKEIEEKWKKEIEEKNKEIKQFFEKNQEKYQKDLELENKMEHLRKKFPQFSDSEIIQDIEYVKKLQEWINDNDFFSKMKKGYSAKRDGFSCQNWHKAVDDKGKTLVIIKTTDNFIFGGFTQVGWTTDKSKWRNDYNDYGYLKDPNAFIFSLRNDKGDRKPNKFRIKKKRNRNAIFYNYSSKGPCFGASEISLNSNLQNGYSNFGNNYNLPTGMKSNSNESKSYLAGSKKKWIVDELESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHW7</accession>
    <name>A0A9Q0RHW7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHW7"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="304" mass="35478" checksum="C48C29B7B613D2C2" modified="2023-09-13" version="1">MLLSLASKNAKFEAKFFFGAVKICAPDYSFTSYLMLLYSFEIYYIYGIGFILLFVRKAITNFYFMILALSISLWNDVILKNIIRQERPEGACSNSFGMPSGHSVSSLCFFTWFTLEILFGSRKNYSKKMKLFIISLIGILLLPVPYSRVYLGYHSKEQVIVGSITGIFYAICFFFLFQKFHKKIYMYFTKWFDIIDDYNPDATRKEVEQKDIENQSLLENDEIKNNDNDNDIDIDIENNPVNNNNNNNNKNKNNNQKNSDDEGETKIIYQVSTSSSETRPREKPKNEQNFDVFFTNSENESDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RIM9</accession>
    <name>A0A9Q0RIM9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000020">
        <property type="protein sequence ID" value="KAJ5079949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RIM9"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="195"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="198"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="283"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="326"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="369"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="372"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="412"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="455"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="536"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="681"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="724"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="767"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="770"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="810"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="896"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1169" mass="133096" checksum="2ED1A19B88B749E1" modified="2023-09-13" version="1">MEKKIQNTLQKLIKKPKKQKEVINWMNQFPENEKLQENCCIALKKLGEGVKVERKKLEEIKMTKFNAIESIIQAINNFPNNEKIQEAAISILKDVVIDSKNRIKIVELNGIELIIKAMNNFPKNENIQLSGCLALLDIGVTSENQIKIRELNGIESIIKAMNNFPNNENIQWRGCWALLNISIDSENQIKIRELNGIESIIKAMNNFPNNENIQWRGCWALKNISTNSENENRIKIRELNGIEPIIKAMNNFPKNENIQLRGSFALMSIGVDSENRIKIRELNGIEPIIKAMNNFPKNGNIQWAGCWALMNISANTENKIEIRELNGIEPIIKAMNNFPKNENIQWRGCWALLNISVDSENQIKIRELNGIKSIIKSMNNFPNNEDIQLRGCLALMNISVNSENQIKIRELNGIESIIKAMNNFPNNEDIQWRGCWALMNISSNKENEIKIRELSGIESIIKSLNNFPNNEDIQLRGSLALMNISVNSGNRIKIRELNGIESIIKAMNNFQNNEDIQLAGFDALNNIKNGIKTNELNGIESIIKAMNNFSNNENIQLAGLNALDNIIIYAENRISELNGIEPIIKAMNNFPNNEDIQLKGLNILDNIIIYAANRNKISELNGFKPIIKAMNNFPNNENIQLKGLNILDRMSNNQDIQQVGCWILTNISYNSENEIKISELNGIESIIKAMNNFPKNEDIQLRGCWTLLNIGVNKENRIKIRELNGIEPIINAMNNFPNNRDIQLKGCWALMNISVNKENQIKIRELNGIEPIIKAMNNFPKNEDIQWKGCWALSNVSVDSENQIKIRELNGIESIIKAMNNFQKNENIQLKGCWALANISVNKANKIIISELNGIEPIIKAMNNFPTNEYIQWKGCLALSNVSVDSENQIKIRELNGIESIIKAMNNFSNNENIQLEGLYALSNISLDNKVYLLSSNQNCYGFGSNFHCQLGLDFETLKISEKPVLMMKNVSKVFSGISSNSVFILNSNQKLFGCGKNNNSQLGLGPNKRKDIHELTQVQSIPKGKIIDIQMSKGHSIMLIEDENEKRKIYSCGNYELNGFGRSINKFTELKSSFFEHGDVIDFSVGENHTLILISNRTIIGFGNNEWRQLGTKKKYFYQTKPIRIKLHKLTFNISDYHLSCGFQNSFIYYISSPFSNLETFLISSFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L678</accession>
    <name>A0A9Q0L678_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding motif protein 14b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000142">
        <property type="protein sequence ID" value="KAJ5066484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L678"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="189"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="528" mass="64472" checksum="C4A76D2AE248196A" modified="2023-09-13" version="1">MNHSITKQKRFFTNTPFENQPTIETQNEKPEINTKENSEQNLYGIEENIKNQIPRSKIPIYYENERNNQENFNQRNFNQENFNQENFNERNFHEENFNQEKFNHKYQYHKHESDSDESMESRNGNKYSSDKESSDENSYEIKYSKRSIHDKDRSDEERNYRFDRDYYRLSRDEKDRKNREIFNNEKIPTEFFVTNFPRDTRRSDILNLFAPFGYVRDINMKNSYAFVSINITKGCDPIRDRNDYLWRNKYLRVEYSKNQDRFFSSEKYRHFKHDLSNESSDNSLSDKENSQSRKHHHHSHHHHNHHNHHHHSHHRDHHHNHKGSSRDHDSRRHDSRKHDLRKNDSSSFSDDQMENEVKRRKDKSTQSTESNESRELKEQQLKEQQLKEQQLKEQQLKEKELKEQQLKEQKLKELNELNEKEQKLKELKEQKLKELKEQEEKEKNQLNLIHTITQFSKEIDQLKNQNIILKKQVEDFKTEIKSVKETDKRKSTENDNVHTHDLKRLEKSRHDHSIKDSNSNSNSLHSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6J0</accession>
    <name>A0A9Q0L6J0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6J0"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="309"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="57227" checksum="C4F74FB29B5937C5" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFQNQNQNENENENYFDFEIICQKNTKKKPISFKTHKSILSTRSAYFKSMFNSKMKEYQENKLILKDFSSSILSSILNYFYSGKIEINLENAVEILIFSSKYLIDELIQFASQFIKENCQVENVVDLLKICESLNLQNIASFCYQFILDHFGEIVKSFAFQDLEENHLNLILSNDQIMVDEIDIFYGLINWGKHKSMIEKETKDLDSNEKLELKNNLKNILHKIRFIDIQEKELSYIFDMDIVPKSISEKMQQFRSNKIGKKTKNLVYLQKFQEEAEKDGSLIFNSRIRLNSRILKDWEYIQIVRQWVPDPDILHVNSLGFSAQRDGFSSRAFHNACDDKGSTLVFIKTKDGFIFGGFTSVGFKSGSPGLLKDEFAFLFTLKNPSNFPPSKFPIYPDRIKSAVESISSSGPIFGSFAPSISSIQYSDIGIHPNLKRGGSDFGFVYQLPSEMRYRSSESRSFFGGSFSWEIEEIEIYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6U9</accession>
    <name>A0A9Q0L6U9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6U9"/>
    <dbReference type="OMA" id="SQETYVF"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37930" checksum="5B1C763F9CAE9277" modified="2023-09-13" version="1">MLEWEQIEPTGDIPPNTCKCGFLTLNEEQIIVFGGSSGFGYNNDIWILDVKKKEWSLIETTGEKPSPRSGVTAVIYKDSLFVFGGFDRRKYYGDFYKLDLNTWTWKELPQGPSGRHSHVGNLYGDDKYIFGGRLNTEGKRANDLWKYSIKSEKWEEMKPFGHIPSARSSLVSAVFEDLMFIFGGIDDQEEGLNDLYSYSFSNNTWSLIHTQGEVEPPLCVSPSAVLSGSYLLVIGGQNRINHERFDFDHVYAFDILRSEWEKWDPAITKNQMSKRSCHVSAMVGSKVVVFGGEVLVPVSYYKHMNEVWILHLLSDLVNDLSHFQKELIFCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7F9</accession>
    <name>A0A9Q0L7F9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molting protein mlt-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7F9"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="619"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="849" mass="97237" checksum="33056DE28752DB26" modified="2023-09-13" version="1">MNKDIYQEFFVACKNGDIEFINKNIDKIEDINHPDLNGSTALMISQFFHHNNISNVLIEHGAKLVLHEAVKDGNIKIIELVLKIPFLNINAVDLTGKTALHYAVMNNNQAIVTLLIKTGSNVNLLDQDHLTPLLIAARNGYLKMAKILIKSGADITIQNLNGMNCLHYSILYSHVDIFKFILKHISSNPETMKILNQQNEFDETPLHCSVENKNQQFITQLIAIGSDVNIQNKQGKTPFHLSIAEEKIGFVGLFFRKEAKVQVQINTQDKDGKTPLIDSIDLGNSFLISILLSYFADANIFDNKGFNAFHHAIIKNQPNTLTHLLRDSRSSPLSTTDGIPCLHLCAICNENMECFDILMKFLKSPSYKEETDREGNTILHHAAKNSRKQFITKHKEITDINKQNEEGNTVLHIIATTGNTELMLQIIRETNINIENKKKQTPLHLSCFNGNYECSKILISYGAKLDQQDDQQHTPLFLALSKGFIDIVELLLDNGAMEQVFDAVKNSNMEIANIYVELGFPSWVNNKESKNLLHYAVEANNIEIAKKIIPTCKNINIRNGNGMNAIQIASKNGFFEICEILIEYGANLIHYTDIMQRPHILAENHKHKKCAQFIKKHFMRDFSIFELIDTEKNYLRILSGLISKIIDPLSNRTSSIEKNNPMISKDQLELIFSNIQNIYQDGSLFLSNLLERFKNWNPKKGVGDIAKNHIPQFVSNYIIYNNNFDRSIQTLKQARKQNHSFANFLKIQEQDPFFQRLELDAILIQPVQRIGQYKLLFEQIQKYTDESHPDYQDLTDALEIVNKFGNQRINLLDQSHRRLIQEGFITFQFLERKSNRFLSPVSRDMKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7X8</accession>
    <name>A0A9Q0L7X8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-10-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7X8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="371" mass="42736" checksum="5137D1C4809BD25B" modified="2023-09-13" version="1">MENEIPSIVIDNGTFSIKSGISGDDHPKKIFHSIVGRPKTNNEMIKFRNKEYIGDEAQSQREVLSLSYPIKRRIIRNWDDMEKIWNYTFFNQLRIPPEEHAILLTEHPLNPKENREKTTQIMFEIFNTPAFYIINQGTLSQYASGRNTGFIVDFGHEEIFFAPNYSGTILPHLVTTLELGGKDLTDYLMKILNEKEIQFQISETEIVRDIKEKLSYVADDFNQEMNKEEKLIQKNYELPDGKIMTFGNELFKCLEPLFHPSLIGLEKPGISEIIFNTIKRSDNDIQKDFSANIILSGASSNFPGIANRLQKEVSQLSSSVMRFKVIPPPEREYSVWIGGSILSSLSTFENMWISKEEYQENGASIVHKKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L800</accession>
    <name>A0A9Q0L800_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L800"/>
    <dbReference type="OMA" id="NFYSTTE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="255"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="473"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="399"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="605" mass="71270" checksum="36A27846124B7C10" modified="2023-09-13" version="1">MNEIIFFGQNQFTKLIKNQTEKITKPIQFKFENENENENEKQIKQISSNYLRTIFLFENKEAIEYLRYPNQNIEKIQIENIQKVTVGFRNVAILTIEGNVFAKGNINLDDSNKFINISSLIEDKNDRIVQDVICSIDSIYLLTSNQNAYGIGSNKYGQLGFDEFEKTEKPILMMKNVSKIFSSNSCLFVFLLNSNQELFGCGYNQVSQLGLGESRKGKKIQKLTKIQNIPKGKIIDIQCGYYHSIMLIENENLKRKVYSCGNSYNNGLGKDQDTNEFTEIKSPLFENDDIREFSVGFSHTLILTSKRKIIGFGNNPFGQLGSRNLEGFQVFPIQIEFPKLLFNKDISNYHIYCGENTSFLYYSPPFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKHRLKDYENEIEKLKEIISKKSIKESNQIFEMIYLNRNTNQKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQLFEYWIYSNQIKDEIQITQEIIDEIKTGIDYFQLNQTNPNLFDLLTNKFNYQNQNQNPIQKKKRKKKKRNRNDQKECLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8C7</accession>
    <name>A0A9Q0L8C7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_13083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="1196"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1629"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="985"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="571"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5067305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1840" mass="216056" checksum="E477CA7AEA6BBBA8" modified="2023-09-13" version="1">MPISFTTKIRNMVYQIIKSLHLECFNRTDSCSLTPTILRTLAFLLTESLDPSQKPNEIIRKIFYDIIFGVWSLAEKYPKNLQNPQAKQNAQEYTDKFLSNLSQFIHIIFTLIWVPRKKMDAFFSQNSRPLSSSPLHSFFQKTLSRGFSTSKMMILEKLFDILEKIGVFSSQGISFTDQDTETSTRETYQEICILLLHSTLCKEKSVCDRSLRLLRALFKGPYLNLVHLVLDREKMIKISSFYIGKSVSDPLEINVTQKKKEDKPKKMSFQRKSVTPDTSLSLDAHDHKNPHLDSVHNKNSELLVFPITMKKENYLPSQERYTNPFLETLSSDINSRLQEFMQQIDQVNEQIQENWISSQNLLHKKAFDIQNELSGIFEKMETRMFRTVQIMEHNLEKLHKKNQVISEKFLHKISHELGSWKEESQNKIIHWKLDSFQDAFGSRRKLKPNFNFDIHYEASLKRDEGTRESTAQKLKEHLRKISLTHKFSMIDLLSSPSKRRLIEKEEDRKNGHNLSKSKQIIDPNLSKSKYITEPNLSKYTNSSDSNLSKSKQLTDHNLSKSKSVQNETIYHQKQNQNQNQNQKQKQNQNQKHNINQKQNQKHNINQKHNIHNLSKSKSVQNEKIYNLLNQKHNKIENQNQNQIEIENQIQIENQIQIENQIENQNQNQNQIEIENQNQNQNQNENQIENQNQIENQIEIENQNQNQNQNKIENQIENENENKNQNQNQNQIENQNENQIENENQNENQLENENENKNQIENQNENQIENENQNENQLENENENKNQIENQNQIENQIEIENQNQNQNKIENQIENENENKNQNQNQNQIENQNENQIENENQIENQIENQNKIENQIENQNKIENQIENQIEIENQNQIENQIEIENQNQNQNQFKIEIENQIEIENQIENENQIENQIENENQNKIENQIENKIENQNKIENQNKIENQNKIENQNKIENQNKIENQIENQNKIENQNENQIEIENQNQNQNQFKIEIENENQIENEMENQIKNEMENQNQNQFKIEIENEMENKMENEMENQFKIKMEKGLELDLSDPLQILLAISHPFMRCYASRVVYRTQCILITPMRKTPGYFCITNNKIKFIASIAAITERTFAKHEIEMKDRSRKIEKMTKIIARRFIHRWTALEFFFMNKKSLLFSFQTEDVVSDVLERLRNLDHSRALFKSTEFCISNPVDFLRKSGITRRWKKHKITNFQYLMGLNSIASRSYNDLSQYPVFPWILRDYTSNTIDLSDPKIYRDLSKPIGALDTERLQTFLERFKSFPKEMVPFMYGSHYSSFAIVLFYLIRTEPFTTYSIQFQDGKFDKSDRIFSSVSLSWQNCLSNSADVRELIPEFFYFPHFLENPDAFDLGTKQTSDAKISNVELPPWAESSQHYVHILQTALESPAVSEHIHEWIDLIFGYKQQGEEAVRAFNVFHNLTYEESVNYLMTLEDEEQQSVEAQIEMFGQTPPQLFSSPHPKRLPAPTHSHLLPTWNTHSPEQINQLYSVVVSEYPLVLIDLIESQRNLPIMNLHGKLVCLDFATQFRAFHWVPLKSKFTQFELELDTYRPRNLCGMISSMKISPQVWNISLVFALSQDKKYLVIGGFWDASFHIASMKNFNTTQKISHHIDLVTCIELQERYLITGSKDTTSTIWNFDPKSGVVDELPIAVLSGHTGPITSVALNIPNNIAVSVSIDGLCLVYRLSDGLFVRSISINPHPVPFNLVRISHSGDIFLASLSDFIIRRYDINGCLLATSSTCGSEIVAWQFIQNDSLLFVGLKNNLIQVWFLDGLKMSMIWQFQSSSPISCITIPRREKCIIVGTRVGEMLIYSFELPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8H8</accession>
    <name>A0A9Q0L8H8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8H8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="486"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="591" mass="68664" checksum="0E4F51E152984E8D" modified="2023-09-13" version="1">MNEIIFFGKNEYPELFKNEPYSIIKPIQFKFENENENENEKQIKQISTGDYSTIFLFKNGKAIEYSRNSKQNPKKIQIEENIQKVSVGDENEAILTIKGNVFAKGYNINPDNPNEFINISTLIEDTNDRVIEDIISGDSSIYLLTSNQNAYGIGSNNYGQLGFDSKTLPKTEKPILMMKNVSKIFSGNNSRSTFLLNPNQELFGCGLNEYGKLGLGESRKRETKIQKLTKIQNIPKGKIIDIQCAYSHSIMLIEDENQNQNPKRKLYSTGRSFFNGLGQDEDTYEFTEIKSSLFENDDNIIDFSVGCFHNLILTSKPKLIGFGDNSHGELGTGDTNTQSIPIQIELPKLRFNENISNYHISCGYDNSFLYYSPFISPFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDDIQITQEIIEEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8T0</accession>
    <name>A0A9Q0L8T0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8T0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="261"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="68898" checksum="DF4F0FC4D8B139EF" modified="2023-09-13" version="1">MNEIIFFGSNESPKLFKNKQNSIINPIQFKFENENENENEKQIKQISIGFFSIIFLFKDGKTTKYDLIENPSKIQIENIQKVTVGFANEAILTKEGNVFVKGKDINPKNPNQFINISSLIEDTNDRVTQDIVSGFNSIYLLTSNNNVYGIGSNYYGQLGFDSKTIKKTEKPILMMKNVSKIFSGNFSNSVFLLNSNQELFGCGDNQFGELGLGESRKKERAINKLTQIQNIPKGKIIDIQCGIYHSIMLIEDENQTPNPKRKLYSCGYWKDNGLGKNEDTYEFTEIKSSLFENENDNILEFSVGNFHTLILTSKGKMIGFGSNEYGQLGTGDTNNQLIPIQIELPKLRFNEDISNYHFSCGNFNSFLYYSPPSFSNLEEDLINLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVINDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLIIKFKNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Z5</accession>
    <name>A0A9Q0L8Z5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Manganese-transporting atpase 13a1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_02494</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="LNIFCTE"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="938"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1474"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1512"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1557"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1592"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1632"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="11">
        <location>
            <begin position="81"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="11">
        <location>
            <begin position="135"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="11">
        <location>
            <begin position="185"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="347"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="447"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1663"/>
            <end position="1693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5068552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1742" mass="200018" checksum="9188C213FB9172BC" modified="2023-09-13" version="1">MQFIYTLEKLNQFNLDLNGEIIEISAGNCDTLITTTTGDCYELCFEPRFSSENPKAKKLNVGNVIKAKVAFEHRLVLTNEGKVYSYGYNNYGHMGIENLSSSQEPVLIEYFTQNNIKIIDIEVGCYQSYCISSNHDLYAFGYNSSGEIGLPDGGNIRTPTKIASNVKRVLSGDYAFFFFYEDFEGNFFGSGSNSTGQLGISKKISTVILEKIPELKGKKVIEISCGYQHSAAVIENEQGFHDVLIAGGPFNKQNLKFRKVKGFENRKVVGICSYCWDGSLLTNQAEIYNYNKNEDFVVEKKLTELLSENIFSFRYEMSGSRKIIYSVAAKNMIVEDFENFLKSQEFSDISIRGNDGSNIKAHKFILNGRICYPNEIEFEKLIGILNEKDKNQIEEFLSFVYTGKCHNSGIINEIGEELGIESFYQKNSGIKKILEFTQGMYYEEESKDFKIIVQNEEIKVHKMILIIRSDLYRGMFLSVVEDLSNKVSDYTGRSIKEVKSIIKFLYFDEIDEDLDEEMIEDFQDKAFLLKKRPIYLRFDITPFGFIYLYLLKEFFQVARNWEWETKTFTVLSLPFTILFQIVLLLSSHWSLSISSRIKYSIQKSIETSDYIAIFPQKNFGSPEIVKIQKDPKKQENFVWNFRTEQNKNENEKENQEIFYNISFLFQKTKYVYQQKGYFKKIDFPTKWNIGDYLEYFHRDIKSISSLQSKYGNNQIDFPNQTFKELFIEHALAPFFVFQVFCILLWTFDEYWYFSLFTLLMLIVFESNVVRQRLRNFDHIRKMQTKPTNCNVFREGKWKKILTTELIPGDIISVVKNTTPTCDLLLLSGKCVVNESMLTGESVPLLKESIMSEDKETKFNTKDYKIHVIFAGTTVVQSINEQAQEKDNQNMIQSAKYRAPEKGCPAFVLKTGFATDQGKLLKKIFFGSSRVTANNKESLLFILLLLVFALFAAAYLLYEGLKKPDRNIYKLVLEATLIVTSVVPPELPMELSLAVNTSLQELSKLNIFCTEPFRIPFAGKVDVCCFDKTGTLTSDKIKFEGIKGLEINNKTSRDLIPPHDIPLKISTILAGCHSLMTIDRSLVGDPTEVVTIKGIKWILQDENTTISPQPRSGKRKRISIIQRFPFLSKLKRMTTVVKVTSETKKRTLIITKGAPEMIKNFLVNAPENYDEIYRESTLNGSRVLAIAYKEIEENSDEVIKEIPREQLESGLIFSGFLVFAMTIKPGTQETIDHLLNSSHSVVMITGDNILTAVHVARKINILEKQELIVYKKHGEQNAQFGLEGRSIDDRIVVDLSKIKENELKKYELCVTGEVYQYILESGELSRYLEHINVYARVLPDQKESVILEMKKKGKSTLMCGDGTNDVRALKESDVGIALLNSGEIKKTAQPKRAPQSLSDFLDAEDTATIQLGDASMASPFTSKLNIIDGVVDVIKQGRCTLVTTLQMYKILALNCLVAAYSLSVLYLQGLKFGDRQMTLTGIVISICFFFLTRAKPLRLLSPERPFSRVFSPYILITIFVQFALHLLSIILLSKLIPILSPYRFETDIDLAKEFEPSIFNSSMYILSVSFQATTFLVNYMGYPFMQGLLENKFLSYLLFFILGLMVMLSLEILPPLNSLFQLAPFRSWKLKLFILVLIFFDLLLSFAFDRLFYYIFKFRPHLSQKRLEIVHQNFEEEKKRIRLEKEKQKEKEKENSESGFDLTKFAEKLTGKKLHHQKKKKGISKATLVRKYGGNKLKSKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L939</accession>
    <name>A0A9Q0L939_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">V-type proton atpase subunit h</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L939"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="5">
        <location>
            <begin position="319"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="418" mass="48738" checksum="7AE1F204D885C1F1" modified="2023-09-13" version="1">MIFLPEIQFKPLSPPKLETKSFTRDILPLFSNNVEHIKKIRSKAVDWDSIKGLLDNYEHVLLFRDIEKKSLDELKIMVQEEGKNLIHGFCIFLTKITSTDILKIFATLFDDLLIEFPSFAEEFNRLEDRQELMDSLIKKILSISMPLSDEPKNYYLLSLYLRITATLLTLLNLLYIDSQGEIQFIYEICLCIWTLSLNQNIVGKLNEVDLAENENFKQKSQKNLVSNSFQTYQSKKKCLINIFADILKTNAKEKDKIVRMILATLVNMSNKSNHNEEMVEAGFLRILNSLYARNWEQQIKENLDSLSTIVQDNLKIFCSWDKYVAEAENEKMEWSPTHKSKLFWEQNIIKFEENDYQLLRVLVHLLKNENPQNVAIACHDIGEFSKYHPRGKQCSTSFKALICVNAKKFFLCGIGSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9P4</accession>
    <name>A0A9Q0L9P4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9P4"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="321"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="396"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="484"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="605" mass="70654" checksum="611472791AC4DF51" modified="2023-09-13" version="1">MNDCLFFGRNLLPKLIKNEPNIITKPIQFKFENENENENENEKQIKQIKQISSSLFSTIFLFKNGKAIEYSRNSNQNPQKIQIEENIQKVSVGYENETILTKEGSVFAKGKDINPNNSKEFINISSLIEDTNDRIIEDIVSGYSSIYLLTSNHNVYGIGSNDMVNLVYDSKTLKKTEKPILMMKNVSKIFSGNSSDHVFLLNSNQKLFVCGNNIYGQLGLGESRIERKIQKLTKIQNIPKGKIIDIKCGYLHSIMMIENENENPKRKLYSCGDYRYNGLGKNLFQNTYEFTEIKSSLFENDDNILEISVGHSHTLILTSNSKLIGFGYNDYGQLGTGNTNEKLTPIQIELPELRFNEDISSYHLSCGSDKSFLYYSLSFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNQNEIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENEKYFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIIEEIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQNQIGKKKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9V0</accession>
    <name>A0A9Q0L9V0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sad1/unc-84-like protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9V0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="513" mass="60892" checksum="3897113098F5916F" modified="2023-09-13" version="1">MNFPTKSLQNKNNNYKENSTQKPNLIPSIFVFFLFIIFFTIFIVSFSNSSKQNNQEEKQIFKTQKIKIKEAKKSIQQEIEDFLDSFLFHFIEKTQFTNDFQQNQISFFYLKNKLLPRFQQILLESKNQNNLEEIHKEFEQFLDSHKTIIFHDLNIIYQKLNQTNFINLKNQFEKKEKQLQEILQLIGNSNQKIQEWNNQFEINISSIKKKSENQMVDFFEKIDNIEKKINQISLNIQALKEDSSDIKKLESELIVYFEEKLDEYKNYISDNLIENVKDLSQKQIREQKQKLNDFLEKEDEVNQMVAKEIQNQFLFESEEKKEMIQKIIENQKNQMKYGTKINFALYQIGARILTEKSTQIFSHLQSNQILGDKSSISQNSNDFCIPNEESILTIKTSDTIKLESIAFKYSLKPQNNPFNSDGLEMGNSKNFSVVLFTQEPDVNLILNFEYEENGFFHQKFQFLQSNLNFQESVLEISGTSFPVNFVSFIFHQDFNSFLICLDQIFLFGEKIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9Z2</accession>
    <name>A0A9Q0L9Z2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-gated cation channel subunit a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9Z2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="422" mass="49184" checksum="B4B6B0CDDCF290D8" modified="2023-09-13" version="1">MDQHCCCCGINLLGFSRPKPLKILISLSPEFNKSTRICNRCRMANYRKIKRLDNNFLIDENERVSSSPKSNHSIQSIQNPIKRTKTTKKQKEEKQLKKLIDENTELKEENMVLSSKLKEVIQENEKLKQEIKRKNSQIKSLNAKQNNPIISCASFNLKDFFVGEWIVQGFISKFDSSTPEKDAFSSGELTLKFDKELIGSLNLTNEDEEEFYYVKVDLDSGLSGNILLSTESTEGPWESLMNIDFDISRKLYFSFQKWKPENQEKGSKYSQIVLLNQKSFVIEIIDETKKEVKSFEIQKKQSQKSSFIKLLLFGIGGGLLLFQLFGKKSNPQQQQQQQQQRRRPRQQIPIKKEDNKEDKKEDNIKKEDNKEDKKEDKKENNKEDNKEDNKEDNTESSEQTESSDSENDNDNDNDNDENKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAH3</accession>
    <name>A0A9Q0LAH3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAH3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="324"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="495"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="600" mass="70135" checksum="E9138118D0240101" modified="2023-09-13" version="1">MNDCLFFGLNKNPKLLKNEPNQITKPIQFKFENENENENENEKQIKQISSGYFGTIFLFKNGKAIEYLNQKNPKQNHQKIQIENIQKVYVCYLNEAILTKEGNAFAKGKDINPKNTKEFINISSLIEDTNDRIIEDIVSGNSSIYLLTSNQNVYGIGSNLFGQLGFDSEKLYKTEKPILMMKNVSKIFSGNFSTHVFLLNSNQELFGCGYNLYGQLGLGESRKEEIKIQKLTKIQNIPKGKIIDIQCGDAHSIMLIENENENEDENPKRKLYSCGRYYFNGLGKKYQNTYEFTEIKSSLFENDDNNILDFSVGFSHTLILTSNSKLIGFGSNEYGQLGTGDTYFHQSIPIQIEFPKLRFNENISNYHISCGYDNSFLYYSPSSFSNLEEDLIKLFERKEFCDILFKTKNGEIIEAHKLILKYRLNQNEDENEIEKLQEIISKKSIQESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB15</accession>
    <name>A0A9Q0LB15_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5068000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB15"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="319" mass="38456" checksum="4E74B19A03A1DECD" modified="2023-09-13" version="1">MNQNLNKIPEIHRSKMEKLIELFPNKQDLAFQILSENRFDLDLTIQKLCQDKETTRWKKIGNKKKKKNKSNILDQSLEFNEKKEIENQPRFQRKNKEPQKNEEIKKSLNSNSKSNSKSNSKSKPKSKSTQKNGKKKKKKNQNQNQEIQKNQNQNQNQEIQKNQNQNQNQNQIQENQKNQNQEIQKNQNNFNLNQNQNQFQSKPKLRWIRKQNQNQNQNNFNQNFSQKNNPQRTRIWKKKEKTTKIIPETKKQKEPINEDETISVEMIEKMNLNELDNEPKHKESKHKESKHKESKHKESKHKEPKHKESKQKNQNKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBR5</accession>
    <name>A0A9Q0LBR5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dedicator of cytokinesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_12343</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="KPFHHSG"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="533"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="11">
        <location>
            <begin position="549"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="12">
        <location>
            <begin position="1406"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="411"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1081"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1081"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5068360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1822" mass="215947" checksum="3DA116F85E3F853B" modified="2023-09-13" version="1">MSCWEKTNKFGVALYSFKNKDAKTELPLKIGDPLHIKEESKDWFRVKNILTQRIGIVPKNYVDIINDPPPNKEEYLKLKILPSIKTNPIIIESQNVLIEWKKLLDHICYQEKNFKKFSELKYSILTLMGYRENMLKNKEPNEETIKIQENQIIDSIDRCKRLLNIPVFPRRENGEIADENNIGLINLYQLHSDQIAQNKGITQKIEAQSTGQTDNNQLLLDFQMAILQLPSEMELQFFLFDNDKSEQVSESYSFRIERSGMHADINLHGKLKTIFKDIPNSDLTPNLYLVCRMMRLGVLLIDEKLQKKYSKKKCREYRRPFGCGILQLSETILKYSKGNMKEETINMFLHSSDFNFFKLHKMLISGEQGLKPLPGLGVKISWVLYAGEYEDLLSIKELELNNKLNEMENAEMIPTDIESNIETENEQKIESEKSFDQKTENENQNENQSENQNQIENQNQNQNQNQNQNQIENQNQSENQNVNEQEKENKESETSIQTNSIKIETQNKKELESKNKEEQEYIESLKHFKHIKSSQQMKFPEVILPSYIRNDLYITVHSGEFLQDRKRSAKNVEMRIYVRKNNAEKFDDFVENCISFGNANETINFYKTYVYYHKNNPFWEETIRITMPTHLFEETHLYIEAYHCTTNENHDNKLFGFAFLPFFQNEAMIKQGKVTLPTYKYVLKTLKEEPTFYLQQPDPKLKQKSKLTQRKEQIELSINLCSTKLTQVSNIIGLLKWKGHSDDLSKILKDLTFSAPSEIVKFIREILDTLFQLLEEKGKDEQSRKMIYESIDFVIGIVADKRFKTFMPVVNDYIQTRFSRASDSKDENTSKENEILTKSLCKVYVFYMDKLKSMLSDFQESNRKTLLNTLRVIEYVFKFIIYSWLLNIHENPNEANNQQKFISDIKGIILKLQDLMSRTQPVWINAAQDMALRNLKSIFFDLSKVLRQDDLTNSFKSMILSIRMESLKGLNHSKLDWIISLLKQGLFDDPDSRSVIFPLLFEQISFHYKQSEEELKLCIDIVKIIINKAFEDLRLPDSKNSRNFIKDIYSLPRKIFELLAHIKYLEEQEIEEVKSKYEKKFQKSQKEDKQQDPKKPTQPKNTQITSIEDTKEYKDKIARVKSKREELTRSLVTCILMLFSTVNEKEINLFFENYDSRLRVRPRFLDSTFSLFMDLIKNPIYLDDFERFEMIQYKIIMKGFKMFHTLMKNFTGRSFIFKLWNLYLETLICFINLPKLQLEKLSNFEKHKILELCGGDLRLICVDLLDNSWKLIGKREYDFISNKTEDFLSFMLLDNEKIKELGLNIYYSMLKCEIEKTQNFKQIEQSTVDTIYHFIREEKDKKFTDYFFKNIEPKFKQDSKLKEKSSNFVEQVHQLMNQITKLKDYPEQEKYEDERTFVLLNLMDYLYRTKRYSMYSRYTHLLSQLHFKNGNFTEAALALTKVIEILEWNEETIEEKMDEGMFNYPRESSSSRKERIILNAIDYFDKGKSWENTISLIDSLQEQYQKNYEYEKLSDLMKRKGEMYSKIVSTERFFANYFRIGYYGNGFNQEIYREFKNKEFIYRGAELEQLSVFMEKIKAKFPEAKIGSDDPNIADKNKNIQYIQISSLTTSSFEEKEGKKKEYDPKMPEKIKRFYQNNGLQVFMYSKPFRKTKEKSDNEFKDLWLRTTYLISEDPFPLFIRRSPVKEKIIVELSPIHNAINSVNEKNDDLEKMITKYEDYDGKNVSPFSMAFNGVIDAAVNGGVFRYQDAFFNPDFLKEDKQHENLVKELKLSLKKQQEILEAGVSLHSRICPDEMRPFHENMEKQFAKMKGLILPSLQDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBW8</accession>
    <name>A0A9Q0LBW8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBW8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="348" mass="41130" checksum="83941C41F4A73628" modified="2023-09-13" version="1">MKFERENKYSIKTELKSFKKNFRLHEIFGYLIEIYNDLSTKTIELFGMEPSNLITQKIDLESNETKFPQIIQISEKEVRDFLAKNVIEESKSLFFLEEFLTKKIRENTFFNLEIKIPDIKASEIQINKKDLQVVTKQLDNKKISIEKKEKIIQELIESRILLNCAYFLRVLIEHIAANPTENSNDPKKTIVSFLSKDNKSEAKLNEIPFFEGLYSQIQKCPSFSSFLMEDLIDLHQSLLSYIEDPIQSIDSHFKERIIGELRIDIETLFENLDSYSQKFLLNSLHQLISQLQNCDPNDLIFDYLSNKIEFDNLSRFESFQNLKLKLKFVIELYQICKSKSERIEENKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCJ5</accession>
    <name>A0A9Q0LCJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCJ5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="71" mass="8086" checksum="DAC6021F8BA96510" modified="2023-09-13" version="1">MSLRVIFDFDLESDSDDSIFVNNDINFPINSLNIVILGLSVSTILALFSLINIILYFLKLFIIVIKVSEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCP3</accession>
    <name>A0A9Q0LCP3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCP3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="117" mass="13846" checksum="DCE35CB97C2BD49A" modified="2023-09-13" version="1">MIPALKQRISSVSQNHYKIQVTKLKIMMQDEVLFKTRFYLSFETFQFYSSDLLFGDPGHYYLLSSLRIHLVEAIKLPQRKKTIRSFSACNLNEVTQLMSSMDLKFTLKIIVPLFWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCS9</accession>
    <name>A0A9Q0LCS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCS9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040364101" evidence="2">
        <location>
            <begin position="21"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="691" mass="77304" checksum="BCB4AE9142923A56" modified="2023-09-13" version="1">MNKLVFFFLLSILLFLFVDSVTLKNYIELPLGMQSTRLSLIDSQSHYVYFVSSNDEVRSFLFKFDTLILEFVEKLDLGQNEVYCGVVDTNTNFGYFGTDNSEGYIIKVDLTGMSVIGSIQVSGGGNFKTAQIDPTNHYAYFISYDPPIPDVFKIDLNSFTQVGSLTVSSDYRYGSAIDLGSQKLYIIGYSSNTTIYTVDLANFVSGDSLALEQDDGRASCAVIDTTTGQMYLGTATQPPKVIKVDLTSFSRVGSYLMGDYYSISHAAIDIPNSFAYFLVEDEPYLLKFNLASSSLVGDLKLNSSSARSMSFNQTNQTLFIGMSGSQVIKVNVQSMNKEDYVVLPDYENPKTILIDEAAQIAYVGFYTNFALNAKINLTSLEILDYLITEDPEQYILYGEIDLDNEVVYYFTYEGLTIIKINISDFSISEIKEISAPGGSNGTLGTAFDNQTHFLYVGFQANDNNTIFKFNSPDLTLVDELNLGEKEIRALSIHSSQGFLYVAYRNYSTGYFTLLEILLSSFTENRNLNLSDYVVDTLLLDTKHDYLYLGTNTDDSVARNSVSAEPTFAEICRIDLSSLMILDCNQLQNVDTVEMAVLSSNQDYAYFFTHSSTSKVFEVTTYNNVITSSQTFDSLSFIEAAATDSTHQMFYVSTDDAPVIFAQFSEYSPGDSSQQILFSFWIFGLMILFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD68</accession>
    <name>A0A9Q0LD68_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD68"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="423"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="888" mass="104831" checksum="E9DF5FC529D924DE" modified="2023-09-13" version="1">MNSKNFNISYFLYFFEQKLEKKDYEIIKKVDETVLDYLWEYMIEQSKNSTLNEFSDEFILMLPEYIPGFDIINKEIMKDLYYYIDILINEGDAVKEMFKKKENQNENENQNQNENENQIQNSNENSNENQNSNEIQNEKQNQNSNENQIQNQIQNQIQNQNQIQNENSNEIQNSNQNENENEIQNQNQNQNQNQNQNQNQNQNQNQIQNQIQNQIQNSKENQIQNENQNQNQNQIQNQNQIQNQIQNQIQNQIQNQIQNQIQNQIQNENEIQNQIQNQNQNQNEIENENQIQNQNQNQNEIEFFEKGIDKISLSDIFFEQISQNRETPRNKKRKGKQRKKPIKNSFNQINLNQNINSQIENDEKPKITKLTIENSTEITEIEIQRIQEEKEKRMKKKRDFQLEFNYMKQFDRKLRNLKEGEKIDFITELPEELALYILKYLNRKEKLLCATVNSDWNYIVFDPYLWSGISLLKIPNVNDSHVKRILNLSGPHLSFLSIPKNNNISPLAFSYLMKDCVNLRHLEFSNNKRITKKEFLELPKLCTKLEELIISNCPGMSTSCCREIANLKHLKKLELSNNNLTHFTQYLGKLTTLESLNYAGNGADKISYSIQFLTNLQELNFAGNSLQELPIQITLLTNLNKLEISQNNFSLFPDSIMFLTTLKKLFIAGNSLKILPQSIWHLSENLISLNCGGNLIEKIPEKFFLLTNLQKLELFYNRLSRIPEGIGKLTKLEYLSLEFNVLDDLPENLSKLRNLKVLRLSNNLLEDIPNFWGSFRNLKILDLDRNFLESLPNTFGELFKLKSLSLESNHFENFPTIISKLVNLKTLNLGSNNFYPKKLDFENLCQLNKLEFIELPSSYLLYVAKGGNDPPNRIRNGKEQFSRNFYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDV5</accession>
    <name>A0A9Q0LDV5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDV5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="281"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="450"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="553" mass="64659" checksum="5660931039F35641" modified="2023-09-13" version="1">MKNEILFFGNYSTIFLFKNGKAIEYLNKQYLNQNPEKIQIEENIQKVTIGERNEAILTKEGNVFAKGNNINPKNLKEFINISSLIEDKNDRIIQDIVSGEYSIYLLTSNQNAYGIGCNQYGQLGFDSETLKKTKKPILMMKNVSKIFSGNYSNHVFLLNSNQELFGCGDNYRSQLGLGNSIIKEAKIQKLTKIQNIPKGKIIDIKCGFGHSIMLIENENENENENPKRKLYSCGNYLYNGFGKDEEDTHEFTEIKSSLFENDNILDFSVGFDHTLILTSKSKLIVFGDNFYGQLGTGDAEYQSIPIQIELPKLRFNENISNYHISCGRDRSFIYYSPSFSNLEEDLIKLFERKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNEIEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIKIKIKIKIKIKIKIKIKIKIKIKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEE2</accession>
    <name>A0A9Q0LEE2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEE2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="18008" checksum="3E2BF95BB7C143FD" modified="2023-09-13" version="1">MIYSNNSKINPKLYYEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQLFEYWIYSNQIKDEIQITQEIINEIEIGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF01</accession>
    <name>A0A9Q0LF01_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF01"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="216"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="286"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="338"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="504"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="611" mass="70784" checksum="E646E5FAE4E03A55" modified="2023-09-13" version="1">MNSKLNSKSNSKSNQKTNDCLFFGKNQSPKLIKNELDKITKPIQFKFENENENGNEKQIKQILTADFSTIFLFENGKAIEYLKNSNQNPQKIQIEENIQKAIACIGNEAILTSEGNVFAKGENINPDNPNQFINISSLIEDTNDRIIQDIVTGDRSIYLLTSNHNVYGIGSNYYGQLGVDSKTMKTTKKPILMMKNVSKIFSGNTSNHVFLLNSNQELFGCGSNYHGKIGLGESRKERKIQKLTQIQNIPKGKIIDIQCGYWHSIMLIEDEESQNQNQNQNQNPKRKLYSCGNYQSNGLGKDEHTDEFTEIKSSLFENDNILDFSVGYSHTLILTSNEKVIAFGWNYFGQLGTGNTQNQSIPIQIELPKLRFNEDISNYHISCGFDNSFLYYSPPPFSNLEEDLIKLFERKEFCDISFKTKNGEVIEAHKLILKYRLNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNRIINPELYSEIKEIINLNEKIEETMKIIYENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIQITKEIIDEIETGVDYFQLNQTNPNLIDLLINKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFK3</accession>
    <name>A0A9Q0LFK3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFK3"/>
    <dbReference type="OMA" id="VQIYICL"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="649"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="83348" checksum="A5F498B1EF16A3CB" modified="2023-09-13" version="1">MKRNQNRKKNRQFIQKKKKKRNQKNRRKNFQKQKKKFITNKNGNQNQLELENQNQNQLENQNENQLELENQNQLENQNQNQNQIQLENQNQNQNQNKNQNQNQNENQNELENQNQNQNQNQNQNQNQNQNQNQNQNQLENQNQNQNQNQNQNQNQNQNQIQNQLENENQNQLENQNQNQIELENQNKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQNQLENQNQNQNQNQNQNQNQNQNELENQNQNQNQNQNQNQNQLENENENQNQIQIKNQLENQNQIQLENENQFQDQKININSNPIPYSFIEFINVELLYQPRSQNKHNQTNEEADSQTKILNLIKIPFYLEQFILLGYFAILDNFLNFFTYFPIQIILSLFQFIFEFPKWIFMKIFQKSTFFIESIKPKFIIILHGTIFVFTTLILLNFEYSFFYHSIRGQSQVKLYVLFNLLDLLEKLFSSFGMEIFDAFIWNFYRKDIGIFHKIGYGFLNYFVVICYCVLHGSLFFIQIVTLNVCVNSESGVLFTFLLSSEVVEIKSTVFKRSFSQNLFQISISDINSRFSISIFLVAIVIINVLGGDPNLPITIQNLFPFYILLIDIFVDWFKHYFVSLHNSSSSNNYKKYTVVLAQDILKIRQTDEKRFEKENQNQNQNQNQNQNQNQNQNQNKNQNQNQNQKSKSKSKSKSKSKSKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG50</accession>
    <name>A0A9Q0LG50_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Importin alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG50"/>
    <dbReference type="OMA" id="MVRNATW"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="527" mass="59297" checksum="F741483AFA31B337" modified="2023-09-13" version="1">MTSSNDSQRVSISVQKNKIGKLFPINSVTVQLLKSVFKLKEVKSLTDPDNKIIEPVNSRFLNLDPTKQYIINSNLSPVEFTFSLDQIPTAIKQIYTDDPQIQLEGATFLRKILSIEGSPPIEHVIKTGVVFRLVELLRKTQDTKLQFEIAWALTNIASGSSEQTKEVLKYDSLPIFVKLLDSHDLNVKEQAVWALGNIAGDSPILRDRVLESGILKPLVEVLKTTPKISVQRNAMWALSNCCRGKPQPQVSQFFPVFQILLEFLHSLDKEILVDCAWALSYLSDGPNDSIQNLIEAGIVKKVVELLDCPFFEVKVPVLRTVGNIVTGNDEQTQVVISFGALPKFHDLLKQPKINIRKEVCWAISNITAGTPDQIDCILNLNLFQVVIELLKQDTIAIKREATWAICNAISGGKKSQIEKLLSFGCIPPLCEMLKLDDPRIIHLVLEGLERCIRIMQSSNFIPETYFDIIENLQSHSNQEVASLALRILELISEDHSDEIELHSHNLPSYQDQDDEYSDDDESETDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGJ8</accession>
    <name>A0A9Q0LGJ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ada2a-containing complex component 3 isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGJ8"/>
    <dbReference type="OrthoDB" id="2306477at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="346"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="419"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="526"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="562"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="598"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="865"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="964" mass="113519" checksum="58A6204E62441615" modified="2023-09-13" version="1">MDVWKLIEENNIEELRQIETIPDDELEKEKKLILHFALEKKVKKEMIELLIEKGAQLKNLETNSLQIAIMNNSEIEIIEYLISKSALVSLNFQDKCLILSSVMKYLNKEDGLEVIQILIEKGFDFKIKNYQNETFLHSILPFQYENSFEIINFLVEKGFDLNSKNKANETPLHFACKNNNKNSFEIIKLFVEKGADINAQNEQKETPLSYACQYLNSVEIIKYLVENGADINITNRRNQTLFHFICQNENQNGNLIEMIKFLIEKGLDINSKNKFNRIPLHYNLQYQNSIEITKFLVEKGADVNSKTKTKETPLHFAFQYQQKENSFEIIKFLIEKGCDINAKNNKDETILHLACQYQRNENSFEIIKFLVEKGLDINAISKLNERPLHLICQNQNENLIDIIKFFVEKGAEINILNIRKQTPLHLICENQNQHLIEIIKFFVEKGAEINATNDLIETPLHVICQNEKKTIEIVKFLVEKGADISIKSIRKQTPLHLICQNQNENSIEIIKFLVEKGSEIDCKNQDDETPLHLCCRFQNRTSIEIIKFLVEKGADINTKNNRKQTPLHLICQNQNENSIEIIKFLVEKGSKIDCKNQDDETPLYLCCRIKSKNSFEMAKYLIQKGADVNYKTNIQSYYYRESNETPLDIAIKNDDLNLIKLLIMNDANVFILLGNELNKHIIEYFPKIYSIIDELNTLLKSNENFTDYQIQSNDSSKFFVHKLILLLRFDNDENLLEKFVEKCSEKPKEIVQPLINFLYTGFFNFDNFLQRFQKYIDFGSEFEQTEKDYKAQKISWNEMYSKKGLITNSKKEEKEKTQKQEDKEYKLIEDFLKEIGIVDSKWIKQKKGRKGILNDFHKLYQESKKDFKIICEEEKEIEVHKLILFLRSELFKGMFLSVQDSSDQVHDYTKKSFEAINQIIYFFYHDEFDESKLTKGIIEELEDIKDYYQLHQNSIFDLIFKNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHG9</accession>
    <name>A0A9Q0LHG9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHG9"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="103" mass="12291" checksum="74E635DA9A0D2198" modified="2023-09-13" version="1">MFNDESTKNFTIIVQDQEIHVHKFILFARSELFQGMFLNVVNDLSNKVSDYTGRTYSQINSIIRILYFDKFDSETDSEVIDDFQDIIDYYQLNSRFIELLNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI32</accession>
    <name>A0A9Q0LI32_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LVIVD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI32"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040330606" description="LVIVD repeat protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="78429" checksum="2B71B5108BAF7E16" modified="2023-09-13" version="1">MQNKLILFVCFTSFLLLVKSNVQIEEVFTFPISLSSPVNTLVDNDEGFVYVVDQMDIESIPDSFLFKFDMNTLEFIDALDLGIKGAQGAVIDTVNKFVYVGTYNSPPVQISKVDLKKFEVDDILTLLIGAQNGAWIGQIDIVNQKAYFGCDSPPVVVKIDLTTFTQETNLSLSQYWFDTLMIDIPNGFLYASTQPNSQVNQTLYKISLSSFSVIDTLFFNSSNDVNLYYGAIDYSTQKMYLGTEQSPPDVVIIDLVNFTKQDVVNIPTLEYSSGIGIDETNEFGYLVDENGVMAKMDLTNNSIINTLNTISDGSGVDSVVFDFEIEKAYIATNNPELIEVDLSLFQVEKTIIPQDYSNPDLLLIDESNQNAYFEFLISNNPSIIKFDLQSLSIIDYLDISQECDYGEIDTLNGFIYLFPTSSNGLNIGKLRLSNFSFEEFNQIHDNGTIESITFDEQKGILYFGYLNNDISNYEMIQVNVTDLTIINNSNFGSQNAILDINIDTSNEYLYSLYSNTSDSNYYLSKINSSNLNIIDNLNFEDSFTEYFFEKSCQYFYFQNSTNNLISRVDLTNMIIMNDSLNVTSFYLTSNYFELNDGSIYLIGSNSSSSDNLVNVLEVELSSNQLISNATLEYSWQSLIIEYDSSKSIVYLLNSDQEPYYLYEIPQSTPNPKPSSSQQILFSILILGITIILGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIA1</accession>
    <name>A0A9Q0LIA1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIA1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="120" mass="14539" checksum="027654F80F8EB55F" modified="2023-09-13" version="1">MKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIQITKEIIDELETGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIE0</accession>
    <name>A0A9Q0LIE0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIE0"/>
    <dbReference type="OrthoDB" id="548769at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="298"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="539" mass="62103" checksum="CB685AC6B978B92F" modified="2023-09-13" version="1">MENQVKIFSNLTNKNEKFAKKYLHKITNNYEEIVNYKEEDGSNLLHQATQKFKIGYDSITYRKSGIKINSQNKKGKSPLHIAVAGNMYDIIELFIENKADIDIQDKSGCTPLFIAVEFGFYKIAELLLKNNANFHLFSKKLLPIHLAARNNNSSLVELLLNHGADPNTISQEGKTAYHYTHSIFVQKILRSKMNPLNFPNYHLLKDIEIINEDISFLSSIISSKFSGLDLDKIGKFFRLALSNRYLGQIKSILQKFHFQNYRDQYENSLLYYAILENNNLLVKLILENGGNPNIIGAENKSPLHIAAELGNVPAILLLLNTTQIYQQKDSEKPIDCARNQVSNFILSHFQQKIILKTRKKSNKDIFNDLVSEFSIFINCWIDMNKIQVLHQIGKGINGKSYLGKWESKDVVIKIVEDLSQPNLALEQKYYNEQMEKNVKIRQKSNVEENINSFFDSKRNFSGKHFFGTFYGYFIDHEENGKAHLSQLENIILKEVFAIGWTECKLKTPSSTGQPCSTSSKKPPQQFPYCIQKRIYYFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIL8</accession>
    <name>A0A9Q0LIL8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-actinin sarcomeric-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIL8"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="738"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="274"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="834" mass="98772" checksum="76FB25C0F51D9DFE" modified="2023-09-13" version="1">MKEELRQKKDYEEQAKKWMDEVNGMIEKLKEREFDNTLEGAIAKNSELTEFMSTQHSEKSAQKSSLFNRSDNINGYMKSLPYHRPEFAHPEGLSPKDLDEKWKELLEVEEARKKDINTELVRQEKCDDIQKKFHERAAKMEKWNEKQEKYLKTEEDIQTLRAAQIQLRKLDNFKKDLDYSEKQVDQLKEMAKDLKELNYHKIDEVEDRMNKLEEHWKSLFELHDTKKNSLEESLKLEENKDALRKEFAEKAGAYRLWCSKSIAECRDAHFGSSLEEVQNFKEVLESKNKEMTTKSEESKTELENLSNQLTELKVADNRYTRLTIEDVKSSHNDLMEAIQNRTNAYETELARQQAMEDKRIEFAKHADEFVKFLDQKKQQLDQVQGEPEEKIEEVKKIYNEGTDANEMFEKLVQIDDEAKSMEIVQNKHTEFDIQILTTKKKWYDNYVKNLLASIEEEKKMKERAAQLQKEWEEQRRKEEMIQEYASKSQSLNTWLDIAHEKTTDPITSTTPKDNEELTKDFHDFFKNKDDKEKDYEELQELAKKMTEANITNFSGLPIETVTERWNEIDQLIDERKKDLEKDKKKQEKHEDKRKKFAEKANHFNEFLEKTKKSITEVTGSPSEQLDKIKKYHSELLKKEDNLEELISLGANLEKHHILNNPYTTFTAQSSKQAYEELVNYSNKLQETITNTILESQGKKVTDQQMKEFREVFDHFAKTNGALDKLSFSGCLKGLGEHMTDGEIAKVFDSFETDKSGKMEFDEFVRFMASRTVDMDTKEQILESFRDLSKNPPVITESEMRDYFPQEQVDYFKQHMTPQGEGYNYESWTDEAFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIN6</accession>
    <name>A0A9Q0LIN6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor tfiid subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIN6"/>
    <dbReference type="OMA" id="DTSIVCH"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="7">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="463" mass="53813" checksum="77836C26811D13C0" modified="2023-09-13" version="1">MSDIFKNTIQNIANSQQIIIKDSSTQILASDLLFRITSIIEDAKKSMKHSKRRKLELQDIKTSFRIKKIESNLNSNFDFVPLLTSTNNRPLLVKDIINEPLQEYPIDSTLYIHWLSIEGVEPQIPENPIVENTKLQKFDYLNRVRKSSNIILGSKITGDGTHEIQVDVRQISSHSKITQELQILFDKIIQTYFSNSKEEKESILFLLANDSSIQPILIYLIDFIEENVKQNVKNIENLYILMKMLRSFIRNKAIKLDKISLRILPLIITCLINANIKSTKSLLYSDFCLLCSRTLSQLFLSILDQNNKIKARISNVFLSVLLNSHSSFRSLYGSLLGIASLDLESIRLVILPHIQILTLKFINHYIQFNHFNFSWKYQAFYCFHLLVSSIGSYYLVFTLDLDWQKNSKKNSNLKFQKQNLLLNEKKEIEKDSYKNESLIFTFLGESFIPFFYSPNLHLCDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIQ6</accession>
    <name>A0A9Q0LIQ6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIQ6"/>
    <dbReference type="OMA" id="CSQPEVI"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="314" mass="35317" checksum="016AB8E7379BDF8A" modified="2023-09-13" version="1">MDFSKCKMIDGALGTEISRRGFSVDGEVLWSAKAILEKPELLKQIHYDYYLAGADIVVSATYQFTFETMKKIGFEKDKSIELFHKGIDLVAEAREDYLKSLNYEIENIPLVGASIGSYAAFLADGSEYTGFFNKTKQELIDFHLERLELCCENPNTDIIALETMPSFLEAEALIEIFNSGKISKKAYISFACKNKEQINDGTLFADCVKICLECDNFLAIGINCTKPEFVPNLVDIANEVMKKQKKQKIIMCYPNLGNIWDSEKQTFLPDSGFSENDFVSLLHNLFINKKCSIVGGCCSTTPEIIKKLAELVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ06</accession>
    <name>A0A9Q0LJ06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob-like protein phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ06"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="723" mass="84291" checksum="D9C9A1854EC5BB5B" modified="2023-09-13" version="1">MSYQSQKLSQKQTRIKTSTSSSSKSQKERMLIIWIEHLIKEQFKEKKLLEILKDGVVLCHLVCRIRKKKTPKRIVPTDSIVKIRSNISYFLDQCKQLGILQKDLFTTIDFVEKKDIQKILLTLDTLSAVAEGLGFESPQDLTLKKKMNETQSKQKSRMQKSNQKKKIKKNDLNENEDKKEKKINGNEKKNSQKMDIDNDENDDDNNDDNDDNDDNDDDDNTEQIDINENILISEDPNDQGILSTQPLDEGIKRKNSKKIIKIKPDAHKKKQNEDKTKLLTTAEKIKLRRVESTNNEKRLKDKKKPIRTSLSYYGKPNIHSNKKNQGKSKNEKVKTSLSPTRTPISPSLSSPLVSTKVPSRLSSKSPTRTPTKTPTKTPTKTPTKTPTKTHTKTSLTHSHPLKTDEKSHPKETRNRGSTFDFRSNKSNLADDKSFEKEYSLKIAKAKHQILESFLTIENTSKTIKEMNEFKKKIVENTVKVNEDDEFEKLTNLSNENIQNESSQKAKKLSIKSVSSFSDFQERNRSGTRNEERFVDFKRESVDSHGKYYPRETLQKLLRDNSENFIEICKCPEDIKQEIWIYENLRQFIIELTIFMGFVLEEEEENKPETEIETKTEKTETKETIYSEAWKTPDDILSILENTNEILGDYEKFPIHLNYIPKQSQRSFKTLSRRLYRSFIYGYFHKQEKFNSFESETNLLKRFSTFATYYNLIPESIQNIIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJJ2</accession>
    <name>A0A9Q0LJJ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="1318"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="966"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="966"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1223"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1548" mass="181044" checksum="AC7C21DD64C733E3" modified="2023-09-13" version="1">MSKQIKIQRRKPKRSFSISYDKLHHSSFISPQKLKQQDLNNVMLEIRKNFEVKSNRKHYQQRRKNFLKIQSPQETEIKNPKLEDFTRKISYDEYQKPKTPQKIKQKNKDKPKLSNILDPKHKRSSLSLKTSNRINQQSINELSQQQIESELSKILDEQKIDPKKRDKINEMSLEKKWKMIQLYKDESKDEDNEDYDDYDSANYYTDHGFSTLSLNQKTQTNYLLSPRYQTRTIFSRFPNQINPNDRTMSSFGDNLSQNRFNSPNYFLSGNGNENENENQFLQTDVEIYSRKQNPFDSPILSEKSEISSDKVMIWMRMNQKMESFFSQETLKDIKTLIGIKGIALLFSVLSTLPRSPFIIQESSNDEIEDTEKDLKIYHHSVLKTLINLTKNSIFFSELASQSDPALLTLNIENIIIPIIIPILLFDILVSYYNDDDPPQLQITELSDTFDLKLILFLLKNKEIPEDTLLNSIVLFGQIINCIQTHPQIPKVDHSLIEDFHEYFLSLNEEIKNDLEDYDFNFSLFEKSYQNSIIEEPKKINNETNQEIQNQNTPIHDKPPTNLIWIKLPHGIYESFELKEDLIVQDIIISCAEKYQGKPNEYGIFASFEDGEWPRSQINQNQNQNQNQNENQIQIQNQNQNQNQNELDFSVEDKQENYLDFDGDFISQNSLISNYKNKKLQILKKPPNEIDVILPPNPKDLTPRWRTIPTDALISTVLKHLCAELNVPKEEYGLLLKLPRDNSHFLESTVTSGVESSVEAHQVSFVPTNDNFHFGKLYPTKNSENAFGIWVIPGNNRKLSAYISRNFTSGYMFIKFQQRPATINLIYPRYDEITNKKISDEEVEIIIDFTVNVKVFIYEFSRIYQLKKGLNYVLYHVIYQESDLEIDLNQKENINEKKHKDAQITDLIKLDEDLAFSFQGIKKGSVLKIIPTVEVHFDKGNQAQDESELEINENDKIENIQSNINENTNENTNLENQTQDQNTQQTNIEKPNEIRRHSRRESSKDNKDMQNILDPVFRQENIDKVSDTMDLWEEIAYGISNIVWENNDNVAENALLYERIRGASLNKSIEILTSQEGYSLAFIDLFLELLPNITDEVLFMQKILVRFNVPAHHPFTKTEIDLEQRKTIQTTVVDLIFRILEFNPQHLPQEIKSMIKNFAQNSLVIHSDPQIKKKGEEIIDMLSDKKQIRRRSVWMTFESIQKELKAMRGELTEPQQNNPQNKDITTKKDDNENKPKETPTQIKTPKPNIEPELEIYIDTDTETQGCCAPKKSKKAKENNKNGAENGGKTRVTFNPNYIIPSPKMPKSKDLQNLDIFQISDIELARQICLTTHDLFQRIHTKELLNNSWTKRNKREISPNVMNMISRFNDLADWVSVQILKETSQKMRVKKIIRLVSITESLYQMNNFNDVMAFVSGMQNSAVDRLEETWKAVPKKVVEQFKILDDLTNAINGYKKLREAFANANLPAIPYLGVYLTDLTNIEELPSRIENNLINWAKRRRIFNVIKKIKEFQGIRYKFVKVDIIQNFLVRDPIPTEDEMWELSFKILPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKP4</accession>
    <name>A0A9Q0LKP4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase II subunit beta</fullName>
            <shortName evidence="2">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKP4"/>
    <dbReference type="OMA" id="QPHARCA"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000006">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="231" mass="26925" checksum="EB0937DF5798B41E" modified="2023-09-13" version="1">MSNNQETKETWIEQFCKQKGNEFFCEVEESFINDSFNLTGISSMVGNNFRDALRKIKGQQTKKELDQEQKIAFDKDTIILYGLIHARYIITSRGLDAMAEKFRNGEFGKCPNFFCKNQPCLPVGLSEKPGQDQLKLFCPKCQDIYYPKLRRHTKIDGAYFGPTFAHLLLFSNSDLNPNQIEQKYIPKIFGFAIHPSAKNSIRKRHKRSQNRNNQNKKNNEEKEVKNNEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKU6</accession>
    <name>A0A9Q0LKU6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKU6"/>
    <dbReference type="OMA" id="VTIQCFD"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF56">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="44"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="246" mass="27923" checksum="5F6C82B9292E3519" modified="2023-09-13" version="1">MEAKIEIDAPLDTGDVKEKYPDAKILDGEKDKELIEECTTTVKKAMVELLEELKEESLKNYKKVEEKNGITKYVRMNEGIKVVRGHGKIRAKPEEVITTLADIKLKKTWDKSDEYDDGTVLAKVTDWCSISHAKYKGTFFTSARDFVIVGGYTKLPDGSYILACRSLEYKDFPPVKKSVRAKLLNADWHLKARDDDPNSCDAIYISQSDLMGNIPKTFANKVALGQADLIRFLDDYLSKEKEKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL21</accession>
    <name>A0A9Q0LL21_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL21"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="117" mass="13202" checksum="B0ADCB142393E1F2" modified="2023-09-13" version="1">MNENQLKIPVQDPYEQLHKQFDKKNPNQKSKTKQEQNPTTNQGNSQQSIPSMIGLKMSQPSGSIVPANQSGFINQVVQVVNEFYGQNPSVIRVRFEYIINGSQKIQQADITQLPFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL97</accession>
    <name>A0A9Q0LL97_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Poly(U)-binding-splicing factor puf60-b-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_08148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL97"/>
    <dbReference type="OMA" id="NGFEIAH"/>
    <dbReference type="OrthoDB" id="20943at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="314"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="423"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="657"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="756" mass="88785" checksum="9FBC00D76CFE1CCC" modified="2023-09-13" version="1">MDKTKKQRKSDEIDNLKTLNNDDFRSKTNNSNQKIKIKTINPKLKKTNLKEKEKEKEETKIEKNELKHEKRKSKETSIKKDNSKNLNQSTHTHHSRNSRNSNQSAHLNHSRNSRSKSHHSHHSNHSNHSHHSRNSRSKSHHSHHSHHSHHSNHSRNSRSKSHHSHHSHHSRNSRSKSHQSNHSRNSRSKSNHSRNSHQSHLNQSAHSHHSRNSRNKSHHSRNSRSKSNHSRNSKKFKRNSNKKSLNSTISNENDNSSYSSSSSMPELERTAMKYITNAKSNQTNGNISLKISQQVSKTALDLKTQEELQLKSQSRLFIQNIDNNTSIKEIKDLFEAFGPIKNMDMPFNPTTKQHKGFCLIEYSFHKSAKRAIEELDQFVIHEKPIKVQWYLTHNALSESQSESQSESQSESQNLMDYQISKKDTIYVGSINWNITNENLEQIFGVFGKIKSCKLSIDKQKGTHRGYAFIQFENEESAQKALDQMDGFELAGKQLKVKPSNIQKTQFKSQFNQNPFFQNQFNPNPFPNPFPNPFQKPNPFFRNQNQFNQNQFNQNQFNQNQFNQNQFNQNQFNQNQLNPNQFNPNQLNPNQFNQNQFNPNQLNQNQFNQNQFNQNQFNQNQFNQNQEIEMEKLDDSHIDTNTRHQLIKRLSREKPTSRCIVLQNMVDSNEVDEDLEREVYEECSKFGTIQDIYVYQSSNKSNSKKEKKENIKIFILYQNLENADKAQFSLDNRYFGGNVITCEFYDETKFLNNIYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLV6</accession>
    <name>A0A9Q0LLV6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLV6"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="534"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="770"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="868" mass="100697" checksum="4AACE934D41D005D" modified="2023-09-13" version="1">MDIRKAIEENNIEFLKQIQMFSKMIYSKEIKSILYFAIQKKVSLQMIEILIEKKANLNFVDETQKNLLHLAIINKTSLEIISILFENQISIHGKTDQNETVLHFACQNNSIEVINFLIEKGAEINAKTRLGETALHFACKFGSLEIIKLLIQKKAYFEAKTYGKKTLLHFACENNSYEIVKFLIDQGMDINAKTNQNETPLYFACQNPHYVEVMKLLIRKKADLNIKINKKEQNLLHFACKKKSLDLVQFLVSEKMDINSRTNLNKTIFHFACKNSSLEIIKFLIEKGVNIKAKNNKKQNALHFACQKNSLEVIKFLMEKGFSIDSRTHHYETALHNAAQNPSLEVVKFFIEKKLYVNEKTYGAISPLHLACQKNSSLEVIEYLIENGADLDSTAILGESVFDFAFKNKSPVEIVKKLIQKVEVSKMNKNRAESILNFILKHNSFDLLKTWVEKGGEIISSLSKKKKIPILHYSMKKRNSFQLVQYLIEKGADINAKNDKNQTTLHFACEYNPSLEIIQYLFEKGADINAKTATNETALHFACKSQSPVETLEFLFEKGLDVDAKAYYSKETPLHISIKSKNPQTIQFLLTNNANISILKKTDITYQFVTLFLQTYSFIVDLDNFLNSEDNFSDCQIESSDGFKFHVHNLILLTRFDHDNSILQNFLNLCQSKSKEVVQYILGFVYTGFPDFKLLKSKITQSGIKNSDSEKSYLSFELAKKEREREKNQKQLIHEFFEEMELDSKWIEAKKGRKGIIQDFHQLFQKESTKDFTIICSEEKEIKVHKLILILRSDLFKGMFLNVQDSSNQVHDYSGKSFETIQQLVYFFYHDKFDKTKITQQIIEEFEDVKDYYQLNENSIIDLFSKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLW8</accession>
    <name>A0A9Q0LLW8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Villin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28894at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF51">
        <property type="entry name" value="PROTEIN FLIGHTLESS-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="4">
        <location>
            <begin position="1408"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="954"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="513"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1471" mass="174226" checksum="F549AD8D27734DF6" modified="2023-09-13" version="1">MKMKMKNEKTPKKDLNPLTRAKSKTKPHPLSRSKSKRSQKLKRTKSKRRSKRQHKSKRGNKRKNEIKDEIKDETKDETKDEIKDETKDEIKDETKDETKDEIKDEIKDEIKDEIKDEIKDEIKDETKDETKNETKDEIKNEIKDETKDEDSEMETDTEVEDETKDEVKEEIEEIEIEMKPLTRVISKTKPKPLLRKMSKNRFNKLSRSKSKRSQKLKRTKSKRRSKRQHKSKRGNKRKNKQPSNPFQEIEEKDKKEIIEEDKKEIKEKDKKEIKEEDKKEIIEEDKKETIEKDKKEEDKKEIIEKDKKEIKEEEEDKIIEEEDKKEIKEEDKKEEEKKELKDHHSRDRKHSTHNHEHSKESPHSTHRHHHSKESPHSKDRHHHSTENTHSKDRNHHSKDSTHSKSRYHHSKDIKEDKADQTKETKQETQETQETKQETQETQETTKKPRGTLKERALLFQKQFEKEVLEHRKEREKQKEKPVEKRKLTHIKKSVARRKGVRRQSKIPTNQIEIVDLKEEAKKEKKQEAVTQQDKITQELTQKLKLKEKNRQSEIQKQEQFEDEYLTSQKLGSGKSKANLFYVKGLRNPRVKLVPCDISSVEHGASFVLDNNYNKIYLWHGKKSNRVSKGKALYYAQNLKTKQHSGRPTIITVATDDTTSEFWKLISGSLDQVKEPLAQSPQNFEKEYIKSIEVYRYENSKLEPVLKGKLPSVNLLNTKYSFIILSPSGVFVWTGKHCSIEDRKGSMKTAKQLNSEKYPEWMIATRNIEAGENSLFKEQFSNWPDQLPISVTKPELIRNIAVVEKQDADYEPDLEPVFKALDSKNKMGIYEEEVVHDDGSGTKIIWRIDENHKTEISKDHYGEFYSGESYIIYYKYVSELKKEYKMLFFWQGRDSTILEKGTSALLTADIDNKELKGEAKHIRVVQGKESQHFYLMFGNNLIIHKDNKDNEVKDNEVKDEVKDEVKDNEVKDNELKDNEVKDNEAKDNEVKDNEVKDEIKDNEVKDNEVKDNEVKDNEIKDNEVKDEIKDNEVKDKVKDETKDNEVKDEIKDNEIKDNEIKDNEVKDNEIKDNEVKDNEIKDNEVKDEIKDNEIKDNEIKDNEVKDNEVKDNEIKNEIKDEVKDEVKDEVKEKEKILYEINTRRNINCRLRKELDISYLEDPKFKTEIKQTVGIEVEFSTERFHPFSCFLFSTKSKNYLWKGKLVLIKDFEIAKKDIVPRMIKNPESLIIIKQGEETEEFLQDIYERTDKNHAALKKEFKLQPSLRLIEKKVPKNFEPKLFFCGIRKGVFSIEQVKVLEDNLDYMSGMILDAYWCVFAWIGLVTSQDIRLQTLKTAVKYWKEIKDERTQKKPDEKSPVFQILAGKEPPQFTAYFVGWDDAIKFYHPRVKIRRRIPSSSNKFSFAETILQKQKRTYTIQELTAPQKPPGLDPKSLENYLSDDDFQLVFKVSRQEFKRVPSWKQQIAKKKVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLX4</accession>
    <name>A0A9Q0LLX4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dedicator of cytokinesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="327"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1142"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="827"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1429"/>
            <end position="1456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1557" mass="183304" checksum="F29A3DEA89DE776D" modified="2023-09-13" version="1">MLDNDAIHPFSQADQIIIELDNSIPIWQNFIQKMNKLKKTQLITQFFKIVKQILILRKQFLNLNLIEEKLLVRKNLVELLTKINQIMGNSEQFRTDNQNLATEENQNIFQLCQIYQRSQTEKLQSKPKEELNHILLKFESAQIPVKENFELYFSLFNLSTNKMISEDFGVFLSDEGTLISHRLQTIFLDLDSNDTQDLYLVCQFIRKGPLVFKEKKVKVKSMKEIPFYRRPFGFSFLQITSNILNQCLKNLTSFTLDVYTFAIDALFPDALKLILNNDPRIEKKPQNIKISLRVLTQQMMLENPENESIVKTNNMRLPRIIFPTSNFNNIFITTINGDFPSCKSKNILIKTTVRQEKGQVIQNCIFAGNGLSSMNEFSSLVYYHKANPQFNETFRVNMSFEQFSKAHIFFELFNCVGNPKTPDKKFAYGFLYFNEKEKILQQGNHKITLYKFHQKTDPKVYLKPQLLLKEKVLQKDELTINFNICSTIIPQNTILMNFFNWRLLYADNPRKLNDLIHLIKNMERDDYFPFIGRILDNLFQVLHQHGKDCASEIFKAFIFLVSPPMDIQQEEFYPIIEDYLNSRMKTISKEQEYFNSLHGYFVECLRQNFQLLQNSEDPSFNRSAMKGLGFAVQFIVFSMTHELKTKNEQNEIQETLKNDRNSLSQLMDDLFASFLIMEPQWVIGAQTFALKNCYSVFVELDKLFDIYQICKFINQLFQNIGSGRGTLDAAKISLLNDISKGILMETAKKRKATIPLLFQHIQKIMYLGQSELEKSTEIIYNILNSIEAYKYKTDTFSTYSGALELTKLPQLLIKAIRHNLAEIQAHENEGQDEKTNENKSPNQDKNEDNLEEEDHFIYSRKDLQIRLVSIFLSFFQRLKPTEVQQFLAIYSKNEMRQANLLIDVFQILKHIITESTVLPSWEIMELQYYSITLKIARQFTSVLQRCFQDIRIYRDLWSEYFNLLSLLIQTPKLQIEALSQDNLIDLFQRFGDMRFEIAHIIQKNWDLLNPEKIQLISSISTNILSLILLEKSFFQSVSLDIYFSMIEIEFDKTGEFKTIEFHTLSVLDDVIENGAYPKFEARFFTEMSKKFAQNIKLKEKGFQFLETMKRIISKISLIKKFQANPEFEDERLELIAELVEYLRNQKQYLMILRYLHMAYNLNISKNNYLEAGFSLNDYSELLDWDSQKQLPEEFEFPAESFEKRKERVLKLSIDSFEKAQNWEKAVELTRKLKDFYEKINYDFNSYCLTLSKEIEYISQIPTPGRTFPKYFRIGFYGKGFEDEKYFNCKNKEYIYRADHFDLLSGFVEKLQEKYPSTQITSKDPTQEIIDSDGKYIQVAAINPVFLEEIEGNENIFDEEIPDFISNYRKNSNIQVFLHSTPFRKNDTKSENEFKDLWLKKVYLYPKEKLPTFRRRVEVIKKLVVETTPIETAIISIEKKNQEINEANKLYSKMSQQQTSPFSMLLQGVINAAVNGGVMNYKEAFLYDNYIHENPSHASFLIKLKNALRKQLNILEKGLKIHEKLVTVQTKPLHLKLSKSLMKLKRLLLPYLSSKDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM96</accession>
    <name>A0A9Q0LM96_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras and ef-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM96"/>
    <dbReference type="OMA" id="ACRMWIQ"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001430">
        <property type="entry name" value="Small GTPase EhRabM3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="201" mass="22715" checksum="E5989C9D7ED0A9F1" modified="2023-09-13" version="1">MNIQNVKLVLLGPTQVGKTCILQRVCDGQYVPDTVTTSGVDFRYSTITIKEQTVKLQLWDTAGQERFRAITGPYYRGANGVVLIYDITSKKSLQDLNYWIESVQKNAPPNVEKMIIANKADLQHKRQVDIEEGQNFADSVNAIFYEVSAKTGENLMEAFTNFTQKILFNGIRNDTKKTVPLNVKDKKKKKKEKKEKSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LME2</accession>
    <name>A0A9Q0LME2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LME2"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040264132" evidence="4">
        <location>
            <begin position="24"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="328"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="628"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="929" mass="103769" checksum="72404F2A7460212A" modified="2023-09-13" version="1">MKQIKIFFLIIAVFIGTTHELNSINFYWDTSFKRPGIIQTELVSPLPPDSTYSSIWCNITGLTTGSETAYSDAQGGCGSPYYPEVSDFICTRYLKFSQFGFDVPTSGESFPNFTTAISMTGLNISFYFSTTAMYQDQFINWNLLYPTSSGLQNVDVTGSIMNGTSFSSSSFTKSFNLASISAQNYYAQSINHDYFGWRGAFKYYDTHGGNYFLKIESILTSIRFTYQTTVLDVTPTTGTAYTKVNISFTPGSVLLNGNYGGSTSNYAILWKCRFQGVYGFDIVEARVLSSSTIQCWPTLPSPNTTANIYIQFHKNLDIMYNTGATFQFLEYCPGYPGNTCSGNGNCSSENVTCYCYEGWAPPNCSELSCVEGGYPVNCSFHGECNNQTNVCDCYIGYDGWDCGIDICQDSLLNCSGNGTCAFDPNHCVCNPENNGTYCEDDKCKYLDCGEHGTCVAGYCDCVVPWDGYYCEIDVCNGTFPGCHDHGTAFMDCSCLCEQGYDPPYCEPDLCKDVDCNNGTVEVTTIEDSNSGVPTGAVIGGAGGGAVVIGLVIFFIVWRYKHSDHSEKNQLLPVFNIDTMFGRDIFLSNSDRKHLKSHGMRHAYLSLEEILLENLELVQAILTDTKNNAVSPIHRAILYLFEQNGQAINLLKYFIQLEVASSTDPNLLFRGINTPSQLWSGYCHLPLGIKYLHDTINDPIYQLAKNQGVDDSNSPQTNISVNKYHLLNGSQMIFDAICRGGDNIPIQFRSILSYTRSLVEQKFPDYVHQSLGSFMILRYFTPALTAYDQFGIMDQEPLSDEIVRMLVLISQVLQKLTTGDLFGEKEEHMISLNSFIETNIESMSKYLDKISLSAEFEDEHKTKSSQLPKDVYTISLAIIHEYIASNHRKIVQSLDTIVQDKNRRLELTNNFKEVRQSLGKSTNLTSHNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNK0</accession>
    <name>A0A9Q0LNK0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Creb/atf bzip transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNK0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="527" mass="60743" checksum="1AE69986D951DB7B" modified="2023-09-13" version="1">MTKKAFKIGGKQTYFALSKFVPYLCLEIQDLDVVLQAAKDMLLFPGMISENSDRILQAFEVNNIKRFGSIDHVKTTHDLAVGSSTLIRTLAVLKPPVFGKCVSLLVRGAKLSQKLPSLDGKPDPLIIENINKVGEEGNEKAILSFIVSETGLKILPDLKKLSPIWSKIIDDYVSNEIIKKSMIGSGFSLGKEGKNASKIISKATSEYEQMQKAFSSGDYLATLRICHKLFTSSPDFFRDNKLDNFLKQNLLPKIGSSMFPEPISLDPIKFSSEDILESNYQKKIAVMKEVYETFPEESEIVLQIRQRIADYNRAVVHQRFLDKNLTKEAREWLENNKIHNANILMEIEMQEMGEKNKYYYSTNMNQPQVNIFPGPLMNSNQNLQQQNLQQQNLQQQNLQQQNLQQQNLQQQNYIQNFQQQNNQQNYIQNFQQQNNQQNYIQNFQQQNYNQKNIQKNPFPVQNFVNMPPQNLTIPKPVEIQLPQVPVYTNESTQLITLEEDDLDEKENSNQEKSKKKNKQKEYSLIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNS0</accession>
    <name>A0A9Q0LNS0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_00064</name>
        <name evidence="9" type="ORF">M0811_01817</name>
        <name evidence="11" type="ORF">M0811_07501</name>
        <name evidence="10" type="ORF">M0811_08070</name>
        <name evidence="7" type="ORF">M0811_11185</name>
        <name evidence="8" type="ORF">M0811_11230</name>
        <name evidence="6" type="ORF">M0811_13292</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNS0"/>
    <dbReference type="OMA" id="RRMAPIT"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5070836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5074715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5075150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5076747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="21392" checksum="F8C8F50D9F880653" modified="2023-09-13" version="1">MQSIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLISPSSFENVRAKWVPEIHHHCSNVPMILVGTKLDLRDDQDTIMKLEEKGLSPISYQAGMDMAKEIKAVKYLECSALTQKNLKTVFDESIRAVLSPVKPDKPKKKCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPH8</accession>
    <name>A0A9Q0LPH8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPH8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="187" mass="21327" checksum="E2CC16BF3BC3C1E3" modified="2023-09-13" version="1">MAIRYLWGYISLICSILLTIISMSTPYLWTEVFSSIDTQVYCGNFGCICKGCTGDYSWKLSDWKDADKTVYRALTVNITFELTGAIILIVALIFLLLPFKKISYWLTLIGGFVITFSLICFLAIFESSMYFINLQKTEQVSFAAWNYSVSVGLELAAIVCALFCFYVVRLENLYSRKDIKFVKSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPT4</accession>
    <name>A0A9Q0LPT4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_07247</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Thiol protease which is required for parasite excystation and invasion of the proximal small intestine of the human host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPT4"/>
    <dbReference type="OMA" id="DEKIPYW"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000096">
        <property type="entry name" value="Cathepsin B-like cysteine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040481432" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="12">
        <location>
            <begin position="67"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="288" mass="32054" checksum="84C71FDE0A2EC039" modified="2023-09-13" version="1">MKLFVLILLLATAFTGLVEQINNANVGWTAKEYPQFVGKSVEELRSLFGKIHGSHNYPIKRHEPQDLPTNFDPRTQWPGCIHAIRDQGKCGSCWAFGSTEALSDRFCIQKKVNVILSPQELVSCDTNENGCDGGFLEMVWKFLEENGVVTDSCFPYSSSGGIAPNCTSKCKDGSSWTTYHAENTQGFKTIEDIMTELYTNGPCEAAFEVYQDFLNYESGVYKYVNGTLLGGHAIKMLGWGVENGEDYWLCANSWGTSWGMKGFFKILKGVDECRIEDYVIAGMAGKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPV9</accession>
    <name>A0A9Q0LPV9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPV9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="43008" checksum="F3066D0F965331F0" modified="2023-09-13" version="1">MVGKICCRIFFWISFWAFFVPPMIWLIIDVVTRSKFESATCEIVDKHYTQYKYDFYDDIPDINPQTTPQYRSPNPFALNSDSNSDFNSDLSYFLSLKNLFGASCYPTPTYNYISFFLLNYTTKDGKEYSEYACNFGRRCWTATGALNCRGQHCSDKISSKDCKIFVNLKTDKVYEKYDIGTADCWYSKAKNEYATIHFPIPSYLWSLFFWVPCFFFCLPVLSYYFKKKTKDENQVRNVHQANHQQNRFENHFHEPKETNETIVIDEPPPKATRNDDFGGMNQLYQNFMQNQNQNQNQFGNNDIYNEPKGNDEIPMEVIQMQMDEYQLAFDNQQEQQNQPPINQFNAGPLYNPYNQDANQPNRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQI4</accession>
    <name>A0A9Q0LQI4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQI4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="160" mass="19471" checksum="4ECAC32BE49FB2AD" modified="2023-09-13" version="1">MLPRIELGTFSKKTIDSQNQNQNQNQNQNQNQNINQNMNQNMNKNMNQIEYQRYQQYAEYQRYQYAEYQRYLYFLQLQQMQRQQLAYQLQQFQQKFPYSSSSSHFFANCYETLPKNFNKTNVMSRYIDATKNLPQSILNLRTNSQIDQQKQIEVPTKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQJ3</accession>
    <name>A0A9Q0LQJ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoinositide phosphatase sac9-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057555">
        <property type="entry name" value="SAC9_GBDL_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057553">
        <property type="entry name" value="SAC9_GBDL_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46817">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHATASE SAC9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46817:SF1">
        <property type="entry name" value="SAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24790">
        <property type="entry name" value="SAC9_GBDL_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24789">
        <property type="entry name" value="SAC9_GBDL_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="3">
        <location>
            <begin position="143"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="949"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="958"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1565" mass="183138" checksum="C5E444A607970D8C" modified="2023-09-13" version="1">MSLRFTFKRGTTHLIIRTLPNSYFIISSLSTRKDTQLFTIDINTGNICYNAQQGIDLFENEKSALFHLTNERKLKIKTTIRAKGLIGIRIVNNSLYLLIATVTKPTAQLFNQHQINTVATTQWVQIQLSYPFSTGKESDNKLLTEFPIDGFHYFCETLDITRPFPSKHSVSDYNPNFCCNNAFLEPFKKLGLLDWCIILVQGIVIGQQIKLENRKTLKEQLENPLKSDENIENMNIIYLSRKLITYFINEDHSDEIDKHSEVENETEYEIICFADHDQEIEWFSYDWISGNANISLEQKEEKLQDVLKQRKSSAFMEKYYQIIGKRFNIKSISCCNLLNQEISQIESESNFQLKKSLQNVHKNVGINLEFLDIYLKWNKKLEEKDRLRDLYETLKKELLKYDCNHGIISSFVFQEEDFSKQENNNENNENNENNENNNNENNENNNENNNENNENNNNNENNDKFIEIDFLRNFPLSIFRCPDGNWVHIQLLQKQKGLVKFNSFNSLDRIISTNFFQIHPIVAEIVHRVNQKNVSQEKEEKEEKEEKNNQWSFFDKKLFQIQKSLSIKINDFIQKGILRECHANSILCSGFLRDLVPISFQSIWNLLDNCTDNITSLIIRRYQKNSKDLINKKKYDFFVGIKEGNLKRSKNNKILNIRNVSSPPSWCLNEFHNEIEDQNNNDFIPERIFSDPNIYWKFPLGRSAKIYLCLNKPTKITEICLTMRGNTIEENRLRMDVFIGQYLDNLFVVLSQVQLPVCSEGTQLYFPFSNTTNYVKTIGTQFRSFDTSPFISSMYSRVVLLQFHSLSPIKRSVVIGKIDIYGVEYSENHQEFSTNFSIRKPSFDSFANFQFPLNNDIPQNLTFLNENNSKPEKSIKKFYNGKQYSHKEISSAHLMKTGIDKVIGQEEKDDKSEDIFNQVEKLLNEEFQEYEIVSDSVQVIHEYLNSENCEKNRKSENNNKNIENNQNNKNNENNNKNNENNENNENIQNGTNWYLKVSTDSNESIFLKNSEESIDILTFKNLINKLVQEKVAHQKKISLLDSLRIEEKRLFLGLKQHERDIIFQKFSISAQEFDPRRFFYPRSKKIINELKRSPRFKAKRCSNPGCNNSLRFHYKQCNYCLRRFCPSCMHPRKIQITEFMWTGLSKVCKSCGEIIFKQTSTMQIIQDLDNSQEEEILEESQENILDLLYSKSSHKLFGMKWQRDIDHSLKLIENSNENLNENSNENSNENLNENKKNINIQEIRKKYPKAIQNVSTFPSASILKYVKTDPLSLPIETLICDEGFQDEDYWKASEDVSSVEIMISLNSYSEVFSIKIIADKNGFTSLDCPLITVLGGMNYPKRILPLAFCDLKEFQNQQQEPIIKPFSEIEIVLKEPTECKIVSLILNLPESKQNQTENLELNSPREKRVIHLAKIIVNGIPKSDPILYASSNYSSLKDKEIKLGMFLENLEKIQKENFTSAFDETTYSLTYEFETPKVVHGFYWISEGMRFEMNRLIFSAVTTTKKGDLNEHIFLGFFFIPKCEDGNILKYYFYLNQSSLIETITVKFLFPIQSKVFSGETILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQM5</accession>
    <name>A0A9Q0LQM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQM5"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="468"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="508"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="612"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="680"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="717"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="751"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="787"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1013"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5077178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1244" mass="143795" checksum="4B69DADC65A5D61D" modified="2023-09-13" version="1">MDQIELMKKFYFAFQKNSFEEIKYIINLGMNPDTKIEMMNFRKRFPYNLNERNYYHSIDFLISTRRINAAAPKLEYRAPLHLVCQYPSSISLDVVKLLVEKGADLNIITNDSETPLHFLCKYQNENSFEVIKLLVEKGADLNNIANGNETPLHSASRNGKSIEVIQFLIEKGADVNSQNNSEETPLHFACQNPKSIEIAKFLIEKGADINSPNRYRETPLHFLCRYQNENSFELVKFLIEKGAEINCKNSSQETPLHLACQNGRSIEIAKLLIEKGAEINVKSNSEETPLHFASKNPNSIELVKLLIENGADINAKNRYGQTYLYIDYDYSNQENSFEMTKFAIEKGFDFNSTTQDNGNLLHLICKKNPNPKPKSNPLEIVKLLIEKGIDVNSQTKEKETALHFACEKEDSFDIIQFLVEKGADVNIQVRYFQQSPLHLICEKQPENSFEIVKFLVEKGANVNSKRNHDLTPLHLICQKRDQNQNLNIFKIVEFLIEKGADLNAKTIYDETPLHFVCKTKPENSFEIVKLLVEKGADATIKTKDQETALHIACLHNSPIEVIKFLIEKGIDVNEKNKSQQTALHFAFYSRNPFETINLLVEKGADVNSKATNEQSILGVACQQNSPFEAIKLLVEKGAEINYKDKENNIPLHKACRDSNSFEVIQLLVEKGADVNAKNNYQQTPLDLACEYQKQKISFQVIKLLVENGADANNINKSNRGPLDLACAYQDSLDIIKILVENGADVNSQKYYNKTPLHFVCDYQRENSFEIVKYLVEKGADIFLKNSYQETPLHFACKNLKSSEIIQFLVEKGSDLSLKSNYGQNPISIILENNNEKAIQALLMNDLLGFDLMKDTRITKEFINIFPKVYSFNQDMKNLLESSESFSDLIIQSINSFKFQVHKLVLLTRFDNDDLILQKFINKCKQNSKKEEIEMALNFIYTGFLDFEEFKELFLNKSPDFPKQEQIEKWNKKQKQLEEFFKEIGIDSKWIEEKKGRKGLLKDFDKLYHQESTKDFKIIIEEKEVQVHKLILILRSELFKGMFELNVKDTSNQVHDYSRKSFETIEQFIYFLYHDEFEQTKEINHKILLELRDVKDYYQLNQNSIIDLFLRDLRKQEIESNQRIVNFNGNLVKLNNFVPDQFINPFQFQDQFQFQNQFQFQDQFQFQDQFQFQESISISESKSISEPKSNSNSKSNSKSNSKSNSKSNSKSNPKSKSNPNHKSNSKSISKLISKSISKSISKINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRA5</accession>
    <name>A0A9Q0LRA5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tobamovirus multiplication protein 1-like isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRA5"/>
    <dbReference type="OMA" id="GHNITEN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="385" mass="45901" checksum="9364B5ADF199D3E4" modified="2023-09-13" version="1">MTVDWNQIEKYAPSAQQSKSWHLYVLGSFYFIELLFSILVMIKALILRKKLKLKSSFYFPFISLILIFIFLLFRGIFMITKIHWPSYFLLFLFYLSLPLYFEFSAFSLFILFLIHLTFRKSANNNKYKQMRTKFYIVIIVVFIAIIIVSIFCTDEDIVVLLFSSTSLVYGILIIFFAIFGFYMIRILKQLRKLDLQNKPIKKMVGVTLFLVVILIYFLLFIIRLFWDFSIILNKNKIADTQKTWQKNHDKRYYSFILSWFSIFEILPSGMLLISLLLYVIRIQEIMQRNIDSEQTFLVDSDDEKNLYIDNKELKSNKKTDNSLTDDLSDLNPNLMGHNITENFEQNEQNEQNEQNEQKSQMGNLHKNFRLTFGKTNMIENDRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRF1</accession>
    <name>A0A9Q0LRF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRF1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="303" mass="35878" checksum="B5CF41E16267D143" modified="2023-09-13" version="1">MEPTKPFIKNFVIQFLQNKNNEFNENFCCYIQTTSKQNKKMIIYDGKYSIPALISTQKSTEVLELDGIFLIEISKCFLILRKNKNLLLKISQLDLLDPLPKSIGDHKSILENKKIQNLLENFHLKKNHFKKKIKSKLNWDVIENENENENENENENENENENENENEKENEKEGEKEKENDLNQINSNQLENLNSQKEMNSSQSNEETNEKSNENLIENSNENLNENLNENSMEDSIENSNENLNENLNENLIHEQIDEQKLFNHLLQNWKPPKKIQTKKELPIYFEKRSRTINKILNKINQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRN8</accession>
    <name>A0A9Q0LRN8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_06887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRN8"/>
    <dbReference type="OMA" id="VFNELEY"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="709"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5076025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="874" mass="100779" checksum="D5038FF957FFFC0B" modified="2023-09-13" version="1">MSNPLAKRAKSVKSKLQSILTPDQEQAQILKEITTKVQRIAFFMRKDLDEQKTWIALDKASSMIEELSTTALSPKNYYNLYMLIFDELRYLELYLHDEIKKGTKAIEIYKRVQFTGKVLPRLYLLVTCGSVLIKSKEVPVKDVLQDLVDMCRGIQHPTKGLFLRYYLIQMTKDKLPDLNSEYSNSRDGSVKDSIDFILFNFVESNKLWVRIQYQTPPANLSEEKKKQAKMMYQKERAEIRTLIGINLVRLSQLEGVDISLYHGVVLPKIIEQIIECHDTLAQQYLLEVISQVFSDEFHLKTLTLLLEPIAKLQSEVNIKNIYNDLIDRLIRYSQENPKMIPNDVDIFNVFFNSFQSVADTCSTITRYELLTILHYILKLSLSLYLAKLDNTEKILNSAKELIEASDKNDPKEIQEFYDILKTALEKYNNANVILELGSFTSSINLLPYEQRRKIAHDFVDNVVKNATIISELDKVKKFLETIQVLLQDSEDAPPYRKDDDYEQAIFESEQESVCRAAHLLTSPNNINETFQILQLLASSFGTGGERRVQFTVYPLIFVALKLSFLIHSHQKKKIEVPFTAKKVFQFVHKILSSLKAILPEITLRLFLQAAQASSKCGFEAITYEFMTQAILAYEEFIVVTNQQYYIISLIISTLQTIRSFGEDNFSSLSNQCGGYSSKLMLNTHQSRAVYKCGYLFWADDVIIEEKVKETKKPKEKKPKKEKKEKKESDSSDSSESESESESESDEEVEKTVTIKPYFHDSKRLFGCVSRAIRVAGSSMEPAAMFELLFEILNVCLYFFDKGAPEINADYINRLLQLILQNKKENDFKFSQLVSHDVLLFFKSTIQHIDYCKKSGPNQKQYSEIDYSQLAANLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS13</accession>
    <name>A0A9Q0LS13_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Argonaut-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS13"/>
    <dbReference type="OMA" id="WTIDAIC"/>
    <dbReference type="OrthoDB" id="17763at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="302" mass="34782" checksum="A3DE72BDA8B211A3" modified="2023-09-13" version="1">MKNQKTTHGGYGKKQPTPKQNKKKQPKKIPEKPQEEKQPIDNQPKNNKKTEQKPNQGKNQGKNQQKNQGKKQGKKQQQQKQGQKKEQEQKQKQKSVSGWEHEGLVTFLGFLLLAYFVIAILIARYYLRGVYGLSDALWACNFLLPHAMWYIDLIAYFITGEFPIGSASYIVWPETPKLELFTTTHHLWFIPLCLTVISFKDKIRFKSWIFASLAMISITSISRFFLPKSVILDDGSTYVLNINMGHNFWDDTPIDFLHTFDNSPPLIYLTFLNFVGSFGFNLIGYLVTAPISHLLAPKLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSR9</accession>
    <name>A0A9Q0LSR9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSR9"/>
    <dbReference type="OrthoDB" id="449062at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="223"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="671"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="757"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="901"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1058" mass="123101" checksum="2B1221CCCCE8604F" modified="2023-09-13" version="1">MNQNQISNQIQNQIEEILINFFEKTFVEIENKLEQKFEQKFEQMERRIRNLEELMIQNKQNFNENSNQEIPIQIPIQIPIPNEFTNELTYQLTNQISNQFTNQIENENPEETQAREFLQKIKDGQFENQDLQIEIHQVSKWMIQFPLNIKIQENGCFFFHQFPYPFDESEYELEKNITESIIKAMNTFQNNHQIQFHGGNFLLTLTFLNETKREQFRILNGIEAIIKTMKNFPQDQNVQINGSKLLIDLTTDNENNQIQVGISEGIQTVLNSMNNFQNDRNIQIIGCQSLMKICQGNLNNQSLFGESQGIETLLKISTNFSNDEEVLFQFFHILLIVCENHSNNLFKVMESSAIQNLLFLMNKFLSNESIQQFGCAIFNHLTFEIKCSLEIQRIKGIETIIKSMNNFPENEELQMHCCQFLANISFQNKNIQDEIQNLNGIQLIITAMNNFPNSQAIQSIGCFSLSKISFDNPENQKKIKELGGIEAIMKAINLFFQQEDFRKSYNEILRSVFNVYGNPKKKRLLKFSINEFQPTIQIMNTFIHNEVIQEYGLTYCLNLMNFNFDPEKKKAFEFSETGQIINIMNHFFKNEKIQKKGTRILRIFVEKSQQQSFQKIEWMHVLNNTMKNFLTNEEISLDALFISRCIFSGIHNDPRTKIESEPILQKMKLIDTIINLINHYRKNQDIQIEAFFVLESLCTSYEAIQKHLIKECQGIEIVLNVMNIFSTIQEIQQRGITILSILTLNSEETKNAIRECQGIEIIITALNNFANSFEIQYSSFRALRNLSFNNEKNQILIKNLKGIDLIIKAIFQFPNKGNLIFVACDVIFNLIFRTQENQNQNLISNEDSYKGLKLLLKQMSDFPNSEEYQKFGSFILASVSFRTRWSFNKNIEKILRLKGIETIIKAMNNFPNQFEIQFQGCKTLANLCIEENGKLIIKKSKGIETIIKAMNNFPTNNGIQLHGCWVFAETGTDPSIVVKIKKGKGIESIIKAMENFPLNEEIQEEGSTSLLRLLASKKVNPNEIKKLNGVEVISKTQMNFPTRSKVTKIVNELLGYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTD3</accession>
    <name>A0A9Q0LTD3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTD3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="489"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="69380" checksum="1AA4E399BD1613E8" modified="2023-09-13" version="1">MNEILFFGLNKYPTLFKNKSITIAKPIQFKFENENENENENEKQIKQISSSVYSTIFLFENGKAIEYLNENDSNQNIEKIQIEENVQKVTVGSENETILTIEGNVFAKGNNINSNDPNEFINISSLIEDTNDRIIQDIVSGAQSIYLLTSNQNAYGFGSNEYGQLGFDSKTLKETKKPILMMKNVSKIFSGNSSYYVFLLNSNQELFGCGYNEYYQLGLGESRKETKIHKLTKIQNIPKGEIIDIQTGNSHSIMLIENENENPKRKLYSCGFYQYNGLGKKGNTYEFTEIKSSLFENDDIILQFFVGGYHTLILTSNSKLIGFGDNFYGELGTGDTKYQLIPIQIKLPKLRFNENISNYRFSCGYFNSFLYYSLSPFSNLEEDLIKLFRRKEFCNISFKTKNEEIIKAHKLILKYRLNQNENQIEKLKEIISKKSIKESNQIFEMIYSNNSKINPKLYFEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILVMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLIDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTL5</accession>
    <name>A0A9Q0LTL5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Titin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040452026" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1510"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="344"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="435"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="532"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="630"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="726"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="832"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="934"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1225"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1407"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1591" mass="175387" checksum="F41D278FE4C88266" modified="2023-09-13" version="1">MKNPKLIIFFGITLIFTIFSISTSKTNPNNNEEVIKLERILANYKFDDTSYTCTKYIAQSFGSDGNNCESYQTACATIEQGLSVSGNSDTVCVYPGHYYLSQTINRQDAWWYIVSTGGPDVTILDGGNARQCMYVHDSSSPLFDGFTFQNCNSGDKGGAIQFYCLIVNWYPVLKNSIFVNNSASKGGAIYNGLCSTELTNILIKDNYASSSGGGLYCNRDLGLIDNDFSWTNVVIVDNTGSGQENIYASSCKYNGNGMSSCNDCYNGGNCQPNGQCVCLAGSSLPTPNCPFCVAGTYSTSTNVASCTQCNQNTYNTGTGNTGCSSCPNGTTNSGNGKTECTPTQMSQPTFDSQTPTSFRLLWGNPPNFSVLGYKVKYTPYGESNWTEVTLVGDVHQYTISNLYSGNYLTQVVGYNNEGTGVWTLETAASTLSAIPPSPPSISEDLSWKSSTSFGITWGNASNGGSPLIGYDLWFHKAGNQTWNTYSFGVDIHSFHITSILSGEYIVKVRAKSELFIGDFSSDFSIWTDPATCPSVITSLNEINHTGDSISINWSAPQSNGGSEIINYQIAFLKIPETNWNYQLVSPDVLEATIPNLIYANYTIAIRALNSITPESDLSYNLTIETDPSTIPSPVNSISQTGKTSSSISISWIKPSNGGSTIIGYKIWYKYENATPSEDFKSIDLFSTNLYYTLTSLLSGTYTIKMQSNNSVGFSNNGTEFIMNTNPPSPPGIMNKPYKISGSPTSITLGWFIPNDQGGDEVKAYKIQYKLSNDSIFTDVINIMNTSLSCIIGDLESETSYDFEIKAYNDAGWSYYWSDIATISTDNSTIPDKILIPSLINSTSTSLGIEWEKPGNGGSDITSYNLYYKLTSDTFWNEILIDLEGNPSPSINDYILNNIYSGNYSIKISATNQNGEGATSDVIVFSTLQPTSPSPISNLLFINSTSTSIYMSWNQPISNGGKPILYFIIEYKGLSSNGSNGNISTNEVVSEYNLTNLLSDSYNITVYSINSIGESEGILVSMNTLSPNIPDIITGLTQISATSTSITIKWDKPNDNGRTIINYIFSFTPYSTNITQYIQIEPPISGYQYQFNSLLSGTFDISISSINEIGQSNYSETLIASTSQPTTPKQMEQVNATTLSSTSIKVNWKKPNNGGLNITSYILSYRFSNLSIQNSTQIEINSTENEYNISNLISGEYSISMKAINPIGECNEWSEDKNISTYSAEVPFKVEELIPIEIRRTYLILSWNEPNNGGRYIEGYNVTCIEDNNLTNSIQIQVNTNQGSFYNLTTQTNYTIIIIPFNSIGFGNSSNFSISTQTFTPSQVEGIFLKNLESYSAVIGWENLNDPDITTYTVLLNTGFNRTNFISDLFSFDNLIPFTNYSVKVRAEINEYFGEWSKSFQFETNKTIPEQIKELYNTKKSYNSLSIEWNKPRINGESIIQYEIKSIKNENENETSETFTTINSGVVANLSSSTNYSIEVRSTNEIGYSIWSNKFYFKTDSEPSTTSKTGLYAGLGTSFGALAVVGGVAFYWYKKRKVVKVTPSVTVYSVNDIDENENEMNDQGNIDDIVMETVNTEKDLYLQSIEETTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTV1</accession>
    <name>A0A9Q0LTV1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTV1"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="494"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68928" checksum="0B801E31C9391A2F" modified="2023-09-13" version="1">MGQSHIPINLHLACYKNSYESVQNAISNGDDVNFQNIQKQTPLHFACLNPNQNSTNIDKNFKIIKLLVEKGADINAQNERKETPLHLLIGKSNPFEIQIQDSNQKRFENLIEIIKFFVEKGADINLKNNNRETPLHLICQFPNQNQKSFEMIKYFVEKGADINSTLRYQQTPLHFICQNHNKNQKSFEIIKYLVEKGADINSKNSQNFIPLHFICQNHKDKSLQIINYLIEKGIDINAKTTEQETFLHLVCNRSNEFSYEIIKLFIEKGIDINAKTTSQQTSLHILFLSMNPNSFEIIKFLIKKGADVNAKTTNQETALHFACQNRNSNPFKIIKFLIKKGADVNAKTNYNKTPLSLLIQSSKNLIIQSNDSFKFNVHKLILLTRFDNNELILSKFIEICSQKSKEEVKNALNFIYTGFFDFDLFFNQISLLSNQEQNQNQEFEEKEKEELFKEKEIEELFKEIGIDLKWINEKKGRKGIIKDLSKLYQQNETKDFTIISEEKEIKVHKLILIIRSELYKGMFELNVKDSSNQVHDYSNKSNETIQQLIYFLYNDEFENEIPKEIKEEYSDLKDYYQLNQNSIIDLFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTW0</accession>
    <name>A0A9Q0LTW0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTW0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="127" mass="15480" checksum="6E85FA95CEFB7C15" modified="2023-09-13" version="1">MEISRKIKQDPHLKELMRKISQETPRLGRKNFIKIQSSNSLLRVFSKDPNRLIWKAELLRRKMFILPFHLLGYHDLCDDVCSINEPNRKRDPISREEFKALFFWLQKNITHIWAEKAKNERRIEYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU40</accession>
    <name>A0A9Q0LU40_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU40"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10809" checksum="11307D39BBF794CE" modified="2023-09-13" version="1">MIKNDKKNFFLLALLAYFSFFIFHFPSWKYKIFELIHFRFSFLIRLHANLFASHFAKRFPKNIQLFPLFNIISTKKSIILHFNYNKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV16</accession>
    <name>A0A9Q0LV16_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV16"/>
    <dbReference type="OMA" id="PMNNNIQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="170" mass="20877" checksum="FBD07151B32EF6B7" modified="2023-09-13" version="1">MQQQQQRFYQQQQMLFQQNPQLYLQQNQQFFGNQNFSHFPFNPQFNQNYQQNYFNSFQNQNQNQNQNQNQNQNINQNQNQNQNQNINQNQNINQNQNQNQNQNQNQNQNQNQNQNLNQNQNQNQNLNQNQNQNQNQNQNQNLNQNQNQNQNQNQNQNLKSKFKSKFKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV81</accession>
    <name>A0A9Q0LV81_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV81"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="70"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="344"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="610" mass="68785" checksum="E9181E090DF83495" modified="2023-09-13" version="1">MSDKLTRIAIINEDRCRPKKCKLECKKSCPVVRMGKRCIEVKNDSKICIISEELCIGCGICTKKCPFHAIRIINLPSSLEQETTHRYGPNSFKLHRLPMPRQGQVLGLVGTNGIGKTTALNILAGKLKPNLGRYSEIMDWPEIIKNFRGSELQGYFNKILEDKIIAKIKPQYVDNIPKTIRGQVSRVLQKKDGRKVSKELIKDLELTPLLDRKIADLSGGELQRFAICVVSIAKADIYMFDEPSSYLDVRQRLKAARVIRSLLPENPYVIVVEHDLAVIDYLSDFVCCLYGVPGAYGVVTMPFSVREGINIFLAGFVPTENLRFREISLSFKIAESVDETQEEIERKSICDYPEMTKTLGNFELSIESGDFCDSEIIVMVGENGTGKTTFIRMLAGLLIPNEGKAKIPKLNVSYKPQKISPKFQGTVQQLLDKKIQPALTNPQFITDVYKPLSLDYIKDQEVLTLSGGELQRVALCLALGTQADVYLIDEPSAYLDSEQRIIAAKVIKRHIIHSRKTGFIVEHDFIMATYLADRVIVFEGEPAIKCVARKPQGLLTGMNLFLKNLEITFRRDPTNYRPRINKFGSIKDKEQKANGTYFFIGDDDDAKNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVG3</accession>
    <name>A0A9Q0LVG3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVG3"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="131"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="280"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="386"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="619"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="739"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1034" mass="121365" checksum="E58D18C0D3DEEEF3" modified="2023-09-13" version="1">MLINKITKKIKQKKEKEKEKLKEIKIIKSGYLTKQGDKHKNWKKRWFVLKDNATITYSKSESTQQNPLGIISLENTLFIQSKIKNTFQILHETRRAFLIQAPDKEVYEEWKQAINKSIELLDPDSKTRNIKVNYEGSMAKQETNRKWKTYYFRVFDNYIGYYQDPKEQNIPIGIIFLNRTTITVEYNTSQEKNVIKISHPIEEPVYIFPVDSEIQNDIKNSNKSFEEQKQNYNILLNEWANIISNLSKKCTLETETNYQTQNFDLINQKEKEKEKLKEIKIIKSGYLTKQGGSYKNWKKRWFVLKDNATITYSKSESTQQNPLGIISLENTLFIQSKIKNTFQILHETRRAFLIQAPDKEVYEEWKQAINKSIELLDPDSKTRNIKVNYEGFMAKQETNRKWKTYYFRVFDNYIGYYQDPKEQNIPIGIIFLNRTTITVEYNTSQEKKVIKISHPIVKAVVVFPVDSNNNSTLDRKKSTGTLIKSFEQQKQNYNILLNEWANVISNLSKKCTLETETKHKIKIYGSIQGNTKKEKENEQEKEKENENEEKNKKEKKSTTSSDISGISEDAQSQSETQSNITLSDPNISDSELQNKPIEKKGQVHKKAVYRLCKKSDSLLLANSGFLCMYKNSNINDPKNRKFKQFARKKKYWFYLEGAYLIYANSQKEIGSESSHSIPLQKAQIVSDLENDNPPFFLTVQLPTKKFLFECESKNELIIWTTSLISSIDRFYCLLKSFQNVQNKGFLSFQKAFGVKRSWNRKYFLIESENLYYFSLDKKNTSNPPDLTTRSPSGVICLKDADFFPIVPYLKKHFTFSIVAANKKKYYFFAENEVNHLEWIKAMNLAICKTDKSFNEDSSKTLPEKELEDLSVITNLSSLEISVMYKRFCVEYPKRFVTKTQFISLMKSLGVSQEKRSNTIFSACDNLSNGYLSFQQFIQVIFLFVNPSFEKRLEFCFRVFDQENQNKITFQNVWSVLCTLNDWNDFGSKNIYSFLEDLFSKIDVKQHGFLTLDDLKENQEKAKYLVKSLNFFNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVN5</accession>
    <name>A0A9Q0LVN5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_05413</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVN5"/>
    <dbReference type="OMA" id="LNVMKFG"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5078155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="198" mass="23566" checksum="0EEC8368FCD2E5C8" modified="2023-09-13" version="1">MDWTEHYPNFNQKKEKVEFLDVGCGYGGLLMELSSLFPEKLSLGLEIREKVFQYVQTKIRVLRKDNPGKYTNISVIRTNAMRTLPNFFEKAQLSKMFFLFPDPHFKRKKYKWRIISPQLLAEYAYLLKKGGIIYTITDVKKLYDWMHLHLSEHPLFEEIPEKDLIDDPVVNAVRFKTEEGKRVERLQGDKFLAVFRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX47</accession>
    <name>A0A9Q0LX47_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000012">
        <property type="protein sequence ID" value="KAJ5080149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX47"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="431" mass="49854" checksum="9A63F755DE09F820" modified="2023-09-13" version="1">MTTEYFEFDPPLEEQQIIVDFGTRSTRIGFSLQETPKFNIPTRKNKPIFHNLFKDIMSKEEQFSSDFVFSSIGNYRFEDLIQNGSIQDWDLMNSFIYFILSKKLEIEAENYSFFFTFSPIFQKSSYLTLVENLFEQFSIPIVGGFLSSQMEMVYAGKTTGIVLEIGYKKTHCIPIYNGKVVEKSVTNLPFGGFDLTNYFNRLLTENGYCFSTSAEMEIVSDLKEKTGLVVFDLEKELELAKNSSLYDINYELPDGQIITIGNQRFRCVEPLFDPNIIGFDTFGIHQLIWESLKKTPIYMRKDLLKEILICGSTAQFPGLKRRFVKEFSVFFDSIPSYFKSIPNENENSNENSNENSNENENQNQNQNENVQKNYLELNLNSTHISIQDSPSISPWKGTALFCGSPIFEKLSFSIKEYEEFGKSILKKKNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYB0</accession>
    <name>A0A9Q0LYB0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000029">
        <property type="protein sequence ID" value="KAJ5079520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYB0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10257" checksum="9250EED536DA4984" modified="2023-09-13" version="1">MSCMLFWNYKLRFVKQVFHMDLFICLFERNPFSLNKSYSDLFDKSQFVKTHTRFRSVAPLTPLSLVLPPFPSLICVLLSIMEKKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYZ6</accession>
    <name>A0A9Q0LYZ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYZ6"/>
    <dbReference type="OMA" id="KHEFETE"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040422954" evidence="7">
        <location>
            <begin position="24"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="776"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="807" mass="94044" checksum="609249F493A458CA" modified="2023-09-13" version="1">MKIILYFLFMFLLLLRLLTTAEQENDEPIEAKADPIIENDIVEDIGHKTAPGKTEIDEEIRKQTQHWSHDEQELIKETMESFKYQADTAKLMELIINSIYSNKEIFLRELISNASDALQKIRFLSLLDASKLGSDTLDDLKIKIAFDSENRLITITDNGIGMTKNDLVNNIGRIAQSGSKQFLDKLHETGDLSGIIGQFGVGFYSVFLVSDSVTVISKHNDDPTQWIWRSDLKGVNETSYTISPDPRGNTLGRGTSIVLHISEDSELDPFLDQEELTDLVIKYSQFIDFPIYMYKYVWENVPIEKKPENDEKQPEKEPENEPVTDFEIEEDEPENLDQDEKIDEPETERIQMWKWVMMNPQKPIWIRNSKDISPDEYNSFFKMLSKKTEDPMTYIHFSAEGEAEFRSILYVPGSLPFGSVEQAMPHNNKIKLYVKRVFITDNFLDELLPTYLSFIMGVVDSDNLPLNLSREMLQKHRLLKLMKNKLTRKCLEMIRKIFQEDDDVKKSRFWSEFGTYIKGGIIEEKRPPFQNKLIDLVRFYSSKSEDKMVTLKEYAENMKEDQKAIYYIGGSRKEVVAQSPHIERLKEMDYEVLYLIDPIDEYCVLAIDKYNGTRFVDASKESLFASDEENKIIEELEEEYEDLISWFKMIILDKVDRVTISRRLKSSPCVISSKDYGVSANLERILKAQPLNQQQMDMLINLYKKTFEINPNHPIIKNLHSRIKENQLDAKTLEMGKLLYETALVSSGYQSTDTPEYTNRVFKILGFSLGVEENEVEFEVEEEQEEQEDEVEFEEQEEIEKPDKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R498</accession>
    <name>A0A9Q0R498_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R498"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="265"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="321"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="493"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="598" mass="70114" checksum="A44DAC69785E248E" modified="2023-09-13" version="1">MNDCLFFGKNTRPILIKNEPDKITRPIQFKFENENENENEKQIKQILIGIFSTIFLFKNGKAIEYLNKNDSNQNPEKIQIEENIEKVTAGYWNEAILTKERNVFAKGKYINTDNPNQFINISSLIEDTNDRIIQDIVSAWSSIYLLTSNQNAYGIGSNEKCQLGFDSETLNETQKPILMMKNVSKIFSGNSSNHAFLLNSNQELFGCGWNHYSQLGLGESRKEEEIQKLTQIQNIPKGKIIDIKCGYAHSIMLIEQEDENENPKRKLYSCGFYRYNEIGQEYEEDSYKFTEIKSSLFENENINILEISVGRDHNLILTSNSKLISFGNNWYGQLGTGDTKSQLSPIQIELPKLRFNENISNYHISCGVDSSFLYYSPFLSSFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQDQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYFEIKEIINSNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4K9</accession>
    <name>A0A9Q0R4K9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase 1 regulatory subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4K9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="621" mass="73390" checksum="E2E4E74EBC4F9ECF" modified="2023-09-13" version="1">MKTNQNKYKALVKQKNQWKEEEIKFWNYQIMITENKQQTMQKQYKITFLTCFEEIKESKPFCLKIQNWNENNEIIISFENQKSFEEFSKNIQKIQQQLIQRKIFDFKSTNVANQKISQKAQYIILFSEKKSKNQPDLKFIFLNESQIQIFSTQNFDKPELIFDKSETITIEEFPSHFLGFIIEKNKNQYLIIFSTLKMKNECFNNINLLFSKKSEEKKESVNQSTIKKIEEKKQKSKSKSKSKSKSKSKSKSKSKSKTDSKSKSKSKSKSDDEKSNSSFGWFGSSDENTDTGIPSDGSVVLNTDSNDEQDEAQSNILKLFEKGDQNTIQIDYDVDESNFEEVQIRKAEKILKIRKEAENESRSSLNLENADLILSRDESVIYQKNLLQEENNSLRAELEEQKHLIDHLSVLHVQLNNTVQEIQKKISENSNPSKQTNITNPEYFEKFSDININLYRAISRLKQSIDELNEEYLPFQDQFNEIQKKILVKNPNTKRVIQKIQKQMEDQNQRFKEFQEKQEKKIEMIQKNMNEESENSTKSKMFNSLQQEILQLRLQFLQLKAQSLKLSQESCIGNSKLRNDLKATDMKFLFQKTRKSYLWGELRQFAMSLDDEKEDIEKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4S5</accession>
    <name>A0A9Q0R4S5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4S5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10296" checksum="AA491BB088FDB227" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4W9</accession>
    <name>A0A9Q0R4W9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4W9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="503"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="610" mass="71384" checksum="FC079E350EA36F66" modified="2023-09-13" version="1">MNDCLFFGENQFPILIKNKSYLITKPIQFKFENENENENENENENENENENEKQIKQISSNSFATIFLFKNGKAIEYLRDSKQNPSKIQIENIQKVSVGYRNEAILTIEGNIFAKGYLIDSKNPKEFINISSLIEDTNDRIIQDIVSGIGSIYLLTSNQNAYGIGLNRSGQIGFDSEKFPKTEKPILMMENVSKIFSGNLSYHVFLLNSNQELFGCGLNRYTQLGLGESRKEETIDKLTKIQNIPKGKIIDIQCGYGHSVMLIENENEYEYEYEYEDVENPKRKLYSCGYSENNGLEKFEDTDEFTEIKSFLFENDDNILEISVSDYYTLILTSKSKLIGFGINSYGQLGTGDTNNQRIPIQIELPKLRFDEDISNYHLSCGLRKSFLYYSLFSFSNLEEDLIKLFGRKEFCDISFKTENGEIIEAHKLILKYRLNQNQDEIEKLKEIILNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVINDTSNKVRDYSELSNKSFQIFEYWIYSNQIKEGIKITQEIIQELETGIDYFQLNQTNPNLFDLLIKKFNNHNHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5V6</accession>
    <name>A0A9Q0R5V6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tpr repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02390</name>
        <name evidence="5" type="ORF">M0811_03050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5V6"/>
    <dbReference type="OMA" id="KYINIWY"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="348" mass="40408" checksum="E62C08E45E8D4795" modified="2023-09-13" version="1">MSIENITSSTQFDNILNTPDQLIVIKWTADWCGPCKMIEPYYQKLSQQYPNVIFLHVDVDEQNFLAATYKIQAMPTFSFYLNKKLLFQFPGADINKLTQAVQKYAVDPIPNPMQCKTKGNEFFQKGDYQQAIKLFTRGIELDPNNHILYSNRSATFLKLNKLIESEQDAKKVISIKKEWDKGYHRLGTSLYLQGLYKEAEETFTKGLKESPNSKMLQENLKELEEFQKKHFDKEKSEEAKKKGNEFFNDGNFEKALEFYTEAIKMDPENPILFSNRAAAYTKLSLFDYGLRDCNKSIQIDPKFVKSYTRKGTILNLKGEKEEAKGMFEFVLKLDPENGFAKNQLEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R635</accession>
    <name>A0A9Q0R635_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R635"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993:SF2">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="125" mass="14353" checksum="1CD9DC5929280875" modified="2023-09-13" version="1">MNPVVHFDIHAEDPLKIKGFYEKVFGWKIQKTENVNFDYWLISTKEGETAGINGGLAKVRDKKGVINSIQVDDIDEAVKAIKESGGKIISEKMLIPKVGYSLHFLDPEENLFYLWQNLKKEEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6G1</accession>
    <name>A0A9Q0R6G1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6G1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="129" mass="15471" checksum="70F773B3738DF16C" modified="2023-09-13" version="1">MESFEEETQKIKRNYKKRKQTEKKEKEKEKKKTKKKTEIEPEIEIETEIQSQTTSSNKFRKKQKQRIEDLEKSAKEVQSKNIKLRTKLYVAEAERDMLATQLSTFQKFVSISLNSRDQEQQKIPNQSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6P4</accession>
    <name>A0A9Q0R6P4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6P4"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="369"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="727"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1014" mass="120091" checksum="1AA138DF2EE7A90D" modified="2023-09-13" version="1">METNDLDFEIQILEEILAESEEKKKNAKKTFKKKKKEAKKSIKKTISNEKNQIDLIDFCSLSEDMLDNFRNLKCDLYSILEFMDQNFLFQNPKQKKLMKIICNSSSLSENDFFVEKKHLFILKKIQSILITKYPKVKKPKIIFQMVEFIKQYFGMKKWIESNILVQKLVEFLEENKISISKKSDEFYSLSSLIFFLEYQKMFEEKLVNQIIIKFEEDKLFNGIEDKEHQNLKKKIIATFSKIEKEDYELDDLQDILIKYFKMIYKKDSKEIVESIVSKSKKISVEEILKKILISTFEMEKIDKIEKFIKDSENFKEIIQKDDLSREERDFINYQKTLRRTNKMLSKCLDSMDIIKLCVAISNPNALEYSPDYLINLLFDILYKTHLLLPFLKGMIFGECITNVLSGTLFRANNLASKLLSKFSRFFGSEFLINNLKPILEEILKSGKNLEVDTLDLSDQEKEENMKNVLEYFEKIMDSIVSNLDNFPPHLKVICYYLQKAAHENHPQKTKSILNGFIFLRFLCPAIASPQIYGIIDFEYSESQRQGLLLLSSALQHWGYGIEFGPEKEFMQPVDKLIQEKYPKFTSFNLAVKIPIQELKEFEKQMNLKNSQKMEILNFKKIAKELKWKTDSFLKPKTTFFPKSSTFCMEDMTQKLQKNAKEFQQITENVAQNLEKLPEIYQEIIGKVEMQFKLRKERNISQNIETISHFATKMSVENTENLIENQVEKSKQNQNQKPKQNQKPKENQKPKENQNQKPKENQKPKENQNQKPKENQIQIQNQNQNQNQIENQNQNQNQNQNQNQNQKSKKENPKLKKENRKSKKNLIKNQNQIENQNQNQNQIENQNQIENQNQIENQNQNQNQNQNQNQNQNQNQIENQNQNQNQIENQNQNQIENNELIFLSQVWKQLGAVPHTLKTNCFFKNHLSKEFKPAIIMLKLNFIAILDNESQIEIFELISLHSGIKLSESKHPKNSNLMVINFQKVHNNSITIISFQNNSEHQLWFNQIKEIQKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7C7</accession>
    <name>A0A9Q0R7C7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7C7"/>
    <dbReference type="OrthoDB" id="5591912at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="833" mass="100793" checksum="D45563DFB94BA043" modified="2023-09-13" version="1">MEKIPKKTIIDWISSKTQTKFTFQLKNKPFWQIIANLICEIDEESKKNRKKDTNKNNKKLVFQLCERINAPKELLKYKQKTDLLPLFRLLYDKFSGVPRARKPFKVPVQILNEHLRKIDIGNIVLKDHNLALTTLESSSKDHATKIEVSRNPLDKKVLKLIIKEDNFFVSFNDDSSRDNFLSELKETKALFENKNKEENDNKEKNDNENDLKFDNENENDNDNENDNENDNENDLKFENEEDENLKRQKEAEKELQRRQEEELRRNQEEEEEFLKNLKKQKGMKLQEEKQKGIKLQEEKEKGMKLQEEKEREIKLQKQKQREIELQKEKEIELELQKQKQKQKEFELQKQKQREIELQKEKQKEREKELQKQTNFEDDFIDDDDDDDDFEVTKIENLQNKKQFKNDKTIFPVKFKVDLLDNHLNNIGAAILIFEIEEFKVQTLRDTTRSHYTNRLQIFFDPKKITIFKINLRDHKYFVKFPNSKQAKLFFLIYNKARSEYQNILRKKEDDFFLKSNQEETYHFGRIDKINETEDEFKRKLFGNQKPKMENEFKTENEFRTENEFKTENEFKTENEFRTENEFKTENEFKTENEFKTENEFQSEKEFRTENEFRTENEFESEKEFQSEKDFQSEKEFQSEKDSSSTKFKIQIVDRHLKPIFQGKIEFENELIIFERENSNKEIFPIENIMIGVHPKQKTIFSIKFPGSKSLFFSTKTEEEAKLLMNEYNERKESKRMKQKSFQSKKFSVDLIDKSFTTIDHATIFFLENQFQFKSNNQSLISGYDPKNLQIFVHPQYSNIARLICNNQKFMLSFQNPDERSDFTQYFESKIEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R883</accession>
    <name>A0A9Q0R883_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Paired immunoglobulin-like type 2 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R883"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040106347" evidence="3">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="136" mass="14933" checksum="700223B3FC29823D" modified="2023-09-13" version="1">MKIKILNLIFLILIIITINCKEIKETPTPTPSISPSPSISPSPSSSTSKTTALSGKALLGTILGVVILLILFWIAYVVVKKKKEKYFVPVGSINEPIFESFSDDGFEQDGDSKKKSQGSDDDEKTYSESESNEFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8J6</accession>
    <name>A0A9Q0R8J6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8J6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="64049" checksum="082CA3518CD0D6F6" modified="2023-09-13" version="1">MTNCCPNSKKRISKLIGNSTVLDFVGDDVVWRVITVFFLSTFFIFTFGVGIRYLFEGTKINEDQIGINLDFFKFPNQTQLYYGESFTAELRVSRKFKSKAIKNCQVTVSASSLDSIQNQDQNQDLSLIQMRDNLINQIQMAGDLTQFSDENGFVKFSNLSIFTGSSQTINLTFFAQCGSHSDWKGLGPSSNFSFQPNNQSDQISFPLYLKSKIHSFYLLNYFSINETINYEEEIDFQFYVSINPNVPEYLKNLSISLVPENSSWNYPEYESYLDYDVISQYQDENEIYHLKLIFFGSTSTKMNITFFCEGFQISGLVYNNNEYLITSYPLNFNSKVSKIEIQENRSLSVKEGEIFAKPWIISVKDNNSNPIGNKTVFAKISKQCNNSISENQSPIDYSKVLLNSIVKTNGNGIANFSNLKFSVSGFTNQYCSFQIKFISDGIFNETENIQVNSSVSQIIWIEHMNHVYTGTTLLNLLIIGFVGSDEWPVIKVQDEKGKGIPNKLVTFTCSNFSARPYQFVTDQNGFASLYMNIPWSAPKKIQLNNILLLLMIFNQNLKKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9A2</accession>
    <name>A0A9Q0R9A2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clip-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9A2"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="35"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="676"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="906" mass="102842" checksum="8B439539B799EC18" modified="2023-09-13" version="1">MSRYIKTTIKEKKKEKPKVKKLVDVDWDKVGEKYDALDFNSIQELEEKIEEMKQNLEKEDWELRKHAILQFHKILNGNAVKNYEEFPRLLNKLEGIFGGLLADEHKAVVKHTTFVVAHLSRKLGKNFGGIFAKNILPGLVRILTNSDGKIKECGDWAIKTTIKNTASGEIAREIKEMMTNGENDEFEKQLAGYGRLILHTWGSNEVEDCVNEMSEVVECALKSKDAETRRLGSRAFWELTNHSVSDSRKIFEKMDSRLQKLILGQKHPDNNPRNKIYEVIKAETSTTGTKTKTSQRSRSLVNKQSVLRARTLKPKVVPKTETKKQTSDSMPRVMSESSVNQDQPTKNRKNRSSTTVSSTKEKNKTLQHKSSSPTLVVKRAHPLARKKSEEKKTKDKQLKKLITEVNSSDFSSKINGLQSLLEISKQQNNAELANGKMFKTALSAVARAMAHNQTKSRVLCLEILREMLDNYTKNFQTNILVALNAIVLLDDKQDQIKETVEDISDLMRTTLGISVLAPALVKTLEKSSPTSKPLVLDYMIKIFSAEKSDYFREASATKNIISALRPLVKIPTLEIKKKNKKILQILKEKNEDELMKQIQSQSKDDRKNFLALLTKAQKTKPVKNRTKRVVLSQKTKIVTKQILSTETSQILNSIKSNISDADDSTTHTNENEGDAGIESSDKDQNHAQKILLQLNDPLNRASALASLLSYSTSKNISFWESAFSPVLFELFKIYFVSEPQLQKEILSLVVSLSTHQENYFKIYTKEILHEYFRICALSQESTVSATFDLMLPVLPVLEPSKALSSISSFLTSDSNSVLLASITLFGKLSHHLQKDLLQKNLDTIYPLLKSNLDKSNSEIRKAVIFTFIDVYKVIGDDFIRNRLAKTLKMSQLKLIVEYIQKEKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9I5</accession>
    <name>A0A9Q0R9I5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9I5"/>
    <dbReference type="OrthoDB" id="10678155at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="304" mass="35710" checksum="4C8411B340F02684" modified="2023-09-13" version="1">MGNSKNTLSISKNLQKKYPKSIQESRLPIILVDCTTHIYATNNSFCKLLGYEEPESLNQIPISSISAKYQPLSKNKSESAIVFVNDQSLINDQAIFHFPWVLKNSKNQKVYVLAYLSLIEFDGNFLGQIIIRTPILKKKQTGNKKQINLSNKIEPNQKFQIYSQKIITEEIDKIQKKIENLKKPELPEQYLLQKIENIQSSFQQFFIQQEEIEKVFQEQKKIQNQNENQLQNFLQNELEKRKNFISQEQKKLEEEMEKNRKVKILYKKIMTEIGQNDELSKKLSIYSQNIGNEFEKTESSSKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9T3</accession>
    <name>A0A9Q0R9T3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9T3"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5071024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="246" mass="29479" checksum="25BF6C9A932AC47E" modified="2023-09-13" version="1">MASLKLQKRLASSVLGVGKRRVWLDPNEISTLSLANTRQSIRKMYRDGLIVKKPVKIHSRARVRARLIAKRKGRHTGLGKRKGTREARMPTKILWMRRIRALRRLLKKYREKGKIDKHLHHELYMKVKGNVFKNKKSLMEHIVKTKIEKKKEDLLLKQAEARRNRTKRLKEKRRGLLQEVDKQEKPKDKPKDNLIEKPKEQPKKQETKNKAELKKKFQEKKKEIQQKKKERQQKRVQKQKPKPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAW9</accession>
    <name>A0A9Q0RAW9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAW9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040221786" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="472"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="911" mass="103529" checksum="BBAC297A5F9A7D13" modified="2023-09-13" version="1">MKLILFFSFFFFLIINIFLIQSNQNQNQDQQNSISTIIQELETTRLLTETTRYYSTPDEAWIWNLLNQFSGSGNFGDSVSIYKDVLVIGADNARKAYIYRYNGTIWNQEQVLDKPSASHFGHSVSIYEDVIVIGAYDANQAFIYRYNESIWNQEKNFYEPLIPYFGWSVSIYENVLVIGAHAANQVFIYRYNGTIWNQEENLSKPSISSFGISVSIYEDVIVIGAPMANQAFIYRYNGTIWNEEQNFYEPSITSFGYSVSIYEDVIVIGTYANQAFIYRYNESIWNEEQNLSKPSISSFGISVSIYEDVIVIGAPYANQAFIYRYNESIWNQEKNLSEPLITNFGWSVSIYGNFTVIGAYNGNKAFVYEGSFIPQVNIVNCSSLFSLFDCYWDKIEFPSTLKYQINYGYDWIDIDYPILEDGNVYYQQFNSSIYDNITGNEYYSIQIKACDNVTMKCGESSSFINLTTKIDSVKDFQLSNPSNNSINVTWDYPNVQINEGIAHLNHYNLSYFIQSQPDLISFISVDNSSLDYFLNNLECENDYNISICGCRTQECEGDDKGEIVDSSISLLFGEITNLTCSISNSIDINCNWNQPINCSIPFYYNLTYQSIYQNDSGNYQSTSSNQQFTVQFPNQEYQINISACNSNGKCGYISSISIKTDNLTSPIIYETISKIEEIEFNFTKLTNANNYSISLNNETNWEKFTSLNLSGNEIIGIISGISGNIEYNISIRGCSDLNCETPYLGLPSSIISTRTKLGNITSLNCNSLINGFECTWDSLILSSGLKAYSFTYNSTSICLTNLTTNYSVSSGLNEGEYYEISIYSSADLNCSFNEYSGINSTTSITISSTNEPNNNSKTTAITLGIIIPIIVIISIIIIGIIFYKKKKRKKSKPKKQEENKEEQELQDNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCH9</accession>
    <name>A0A9Q0RCH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lysophosphatidylcholine acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_01209</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCH9"/>
    <dbReference type="OMA" id="HACHITY"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF52">
        <property type="entry name" value="LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="115"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5074578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="36483" checksum="519348A6FD592F2B" modified="2023-09-13" version="1">MTEKESKSKKVEKEEFKEEYKPFTDKKYTTQEKILMIIGFILYGFIRLVICLLLAIIYTLVLKIASLFTEIEKKRKFMKIWTSIVVRMILLSLGFWRIDLIGKDKLRKSIEENIRIYIGNHTSSMDIALSMVLFLPSFAAKKSVQNMFLIGFLSKVFQSVYIDRTKSNFVVIEEIKKRAKETEKPPMAIFPEATTTNGEYLIGFKRGAFNPGTKIQPMIFRYKKGWPFNFIQYEWSLRNGVFHFLDMFCNLFTTVTVEFLDPYEPNQEEKEDSKLFAENVLKYMSQKSGIPISPANFSHKIEYAKKIGTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD00</accession>
    <name>A0A9Q0RD00_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD00"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="150"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="555" mass="65699" checksum="21FD90FD00888D05" modified="2023-09-13" version="1">MNIPIQISIICHEIDIQKYKKEDLLAILLYFNANQDKWEEKKNFKLILKDETLQFEFPFDFNYQFGTKQFFNLLLLQDNKDKEKQELIGSVQFDLFEIMIKDEKVINKPIMNMENKVGTIDIQITELLPKGLTEKVKIVIPPYPPEDQQILNKHYFLKDAQKKVKTLVGLRIKIKAENLDKKDKLGKSDPYLKFFFKKDDWKLMYTTEIIKKDLNPTWKEFVIEGSTDDFKVDIKIMVYDWDKIGSHDLIGEFETRFRDILKKDQKFELIHPKLKQKKKNYQNSGVIIFEYVKKKYEEQIQTVKVRELLPPLVPFTEHASIFDYFHAGFDLKPLICIDFSKVKSDASFHSKIYRDNKTGFDYALNEIIPFLQHFIQDKNFFAYRLPLRDRLITLGEERELPGEKIIEYYHKMISKKEVEPGKILVSPVIKEAISYLDGLKDKNRYCILFILLEKDVEDVDETIQALSQASNYPLSVVFIGIGEHFAHKFDNSESKRECSSFFQLVWDKSYFNDEIHHFIKETTGKEISQEGIPYVSLLSSFGSQILEYMRLFRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD76</accession>
    <name>A0A9Q0RD76_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="PQNIHLY"/>
    <dbReference type="OrthoDB" id="19599at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3298" mass="396520" checksum="877EFD7735C34D47" modified="2023-09-13" version="1">MLFKFNYLPKNELIFSCQNKENTYKTFNFDNFLQIKIISQNIKQNELFSENDPIQKYLNSFQKIFPIIKKMFKTCVELKKLYIIESNNKYEKVIEYSSINESDKFKNELIKNEKELSQKLLNWKKEKDLIKQNHFVYSLFFQEQLFEIMNLCFSTSLQNNHNLFLLLRLFNPNLTQEDLIEFRINIIPEFDPSINLKNFIEELSNLISFKNSIQQRLIQFKKKEIPKKITKKFNHLFKNEKSVQNSKIFFYKIDKKIQVYEILTSLYFGYCNHLPLKENVMICNSKNTNQSDIENFFNIYKFYNQDKSKINHEKHLFSILHVQKLSQLCSNFLIQKIQQISFETHFPLIIFFYQKDNYQIPNIVSHFPNFLISEKIESIPEEDLKSIFKNHFKNYKRIKLFTSKIPGMGKTYQIRKYFYEKYNQDQENKSIYLYIKISKGTKSEIIQEINQILNKNSINFQNKIKFLHIDLTFSPILETLDFLWELSMWNSFEDERKLENNLIWIFDDSFKIVFEIPSYIKSSSENGLNNFPPLKYFKEKECKMNSDNFSFSSYPILNFQIEKEENPELKKIANLIQSNQNHLREYKNTNELTEIVNNLNQEPNSKEYFNLLLNQFENNLQTKFISFRTFSNFQYLMKNLLQYFMWLLFNKDEIIQKNFENDSEKYYYFLNQIIANCLNFNIELASPFFHFNSNLENSNNLEESSKLLKNKIEWKKRNLSFPILFRNKKNKNQEGEYKLFLISNYEIKQLFQNGLNFDNQNMIIFHEKLKNETKIEIEMKDILQIFNSLIPKSFEITNEIIQNYEENQKKRGNFLTSENLFKMIYIQLKLWAKIPVIINGGNEYEKLLLITYLIEDILKQPLIIFNVNFQTKKEEIIQEIQQIQNQNTNPIDRINIYFHEFNKGSKESISLIKEILLNRSINGKNLQGNIHLLASLKSFSSNQFERNEKTQFISQYQLISDSFYEDIYDFGKLTKISKKKYILSILHQLFQQKKENLQNFFNSKISIESESQIILKLIRFSRKLTQKLQIETKSKSIIFSNEYFESFQDVLIFSRIFNWLISSKIAQKLIKENEISTQITSSILLSLFIVYVSSLNEGKRKEFLLKFEQKQQKLKKNEKIKMNIETNFYKISENLIQNMENYLSENNIAKTKSFKENVLLIFISFFTRIPLFIIGNSGTSKSTSLKFILKLFNENENELNLPNLQINKIECSQILSPIQLHNQFNNSEKLSQNYKKEIIPIIILKEFTNLKDKTLMTLNLEIEKIQKDIQLTKLESFLTKPSLILFSNQFSKMNYISTGIILNNELPNETELESITKEILNSFPRESPKNYFKYFVKIFNGICQNQKILISKQTNLIKIQEKSLTTNFYGIYDYYFFLKNIGFYFSKNNYSIFSDVLFNSLYRNFGIRGKILKEVLKLNQIDGFETIPKFDLEKLITENLYKTKKLQEESDQSYFEFMKTSRYLMLIISHISIFSIIYQKYFPDSIVIFDKDLLLLLFDKSLNISTIPKEEKIKEKLFNIEYCISEGKILVIFDYQKIYPFLNNLLNQNFDEENGKFYTKIQFYNEERKVFINPKFRLVLVTIKENDYEFKEQNLLNHFEKHFIDGSTTSSLNSFFNYSFSLSKKEQNFLKKINKFFDPIETITRNKIQTKDLIFGFNENLFISLILKLNSNLNEKIMKKTIFQLCKFYKMNEVKQFISKSKPKSKNLEEKTNNILNDYFSSSFKNFDELFNQEIIGNKIQNSIIFTTSFETKMKINQEKIQNYSIQDINIQSEKKVIEIIKSSIKNRESILSIHFQQNEIELFFKIKFFIEQNLNQKNYIIIFIHLSPQFEMKDVPFYFEKNWEYYYIEKLYPKIFLPLINDLKFNHKIDTINDSEKENKMKEIYRKLLKISISRNIDFTSEKFIQTTKFIENELFSSKNEINFSQKIREMIELGIKTNHFLFDSEIKNIIQQNENQNQNQNENEIYISPSLYDKFIQMIIVIIGIFFKNINQNENLKLLDSDQKTINNMWKTFFNKFEIPCFEIEIENQNNKIIELDIPFISIIYSIIQQYQTISEQKISFSEFIQIPFNDKRNKKIFKKEKINEEIIGKILLDFIKLSFNQQQQNFLNSFKIEFLIKWVQNYKSENSNLEDISFMEIYKIYFEKIHQNLINLIEIDSYFKIISEIRHFSILSFMKKLIPKLQKEQFLIKEKSKKIEELFYFLIENEGKTEKKQKSIESLYDKWNLELFKNEFGIELTNFNEETYQIIEDKMMINKITSELIKELFSQNVNCNNILICKKSQKEKSQIYLTIKLKRKSKEEDENQKKCPICEETFHKNNKHFSILNENYIDHYRKKIRSIILNFIKYLAFYGEIIFKKLLFNKKMKGKFDFTNIQQFFNYLISKTNYLLSLNSTEILYSVYIPLLTNLISLNEEDDIINFIEEMLQKTNLKLLENQQENIIFICCMKILNENEKLIKYFIQRKEDQEKKKSKNIIAIFSKDGFSLRKIAKFLKSRKNFIQKPQKFINKMKNSLIKKQDTWLKFIYNEIQKTQGINNLKKFIKNSVDEKIKECKFSQEIFNKIQDDFLDINIKGKKKEKTLIHYYEQNKIGNNLLNQFTESHIGFVSEHGTSYLDSKLFQNLSKIEEKIEDEEIIKMAIHSIEFISGLKIEPFQFLFSSDLIFEVGESQLKQELLEKLYWPSMGSYSFYPDFINEKEEEDKLNLWSLCKKNHLNFVKFSHIKLQNWCEFCLSKLKVNQNQKKIDSKFFENCTSYSVSKFLNTNPAFTFRKMHPITFRIIRLFIHLSVISISIISEKFSRHFISLINNFVFKPETQEELINQLRSHIGNDLSILSGLLNLSNYQTILYYHETLNLISQYKIPENLFRKDNFLDLDYRNKFEEVFSNIYNKNHSTIIEKVIKNTKKIQKIFKQPKEKLNNVSIFVKFVIENIQELKILNLFEGFIKFGSYVMQKFNQKITRKESRTIQFKNIIENENQDLYFQFQEYWNLCSKETKYLQIMNEIPINEFIIEINEESFIDNYENQEINYPISLNDFNSIQFFNFDMKEFEKINNYNNSFNELKIFENYIKKEIENLKKPFILSSKIKNFIYYDEKPELDIEFLNNENWKQEEVDIKIWRKIKNELENYGLYGKCKELIEVVISSCKMIEMKDLNKMKDLNKMKDLNKMKDLNEMKDLNKMKDLNKMKNLNEMKNLNKMKNLNEMKDLNEMNDSNEMNELNEMNELNEMKELNEMNDSNEMNDLNKMNELNEMKDLNEMKDLNKMKDLNEMKDLNEMKDLNKMKDSNEMKDLNEMKIQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE76</accession>
    <name>A0A9Q0RE76_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyanophycinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE76"/>
    <dbReference type="OrthoDB" id="4666063at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03145">
        <property type="entry name" value="GAT1_cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36175">
        <property type="entry name" value="CYANOPHYCINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36175:SF1">
        <property type="entry name" value="CYANOPHYCINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040287526" evidence="5">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="407" mass="45914" checksum="20709A2B40605942" modified="2023-09-13" version="1">MNIWKIISLLIVIQFIMATATEPLVLIGGALADENEAIYQQIINFGGGNQKARIGVITAGSDPQDAKANAEYYCNLFRGYGVYDCSWIPIDLDHKENNQDPQVLSLIAQMTAFFFGGGDQERISECFFNSHEDSPALSLIRKLHTEQNVVISGSSAGTTIMQGNYMVTGGESYNAVTQDKPHSYIDDNYPDDLSYDPYPGFNIFTLGLLDTHFSQRGREGRMIRLLDFSRISYGFGIDENTALVINGTKGKVIGEGGVWVFNMKKINEKKDELRASDWEIDNVLGSYLTLDDEYDFTTNSITFASWKSSLYGREIHNHPMTPTDDIFSSPNNSELKDRRNPNEMEIVSCDLFDSKGSDTYGLTYEDDPTYEVDLTKDRDQGADGYQGYFNDINYYAFENLKIDIFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF12</accession>
    <name>A0A9Q0RF12_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myosin-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF12"/>
    <dbReference type="OMA" id="TIHEMRI"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="310"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="658" mass="78778" checksum="8F6F23D044955897" modified="2023-09-13" version="1">MKSTQNERKIYFQFAIVSINNFEPKTEKVFVRWKCGKNQGNTKKININSNGEGILNEEFEVFLEVLFNEKEEQKENRNETLAQIKLNISKIIDINEAIIRHYQLKPKHQDSQIQKPIIVIVMKIWKNFKEKKFENLLSLKNIQEQLYSKNENNQKNENNQKIEKNNLTLNLDQKEDEQIQEFILSPFQNENPFDFNLQNINTKFGHLSPRLTSFILNQKQQKPQRKKTQKKYTGNTQIEYLKKLIKKEEKKTKNYEVIELGRNIMDRFFFFIKPKFNKQAPISACFIFKFLVYHHIFNPNYSQFFLEFYESIIKFVEFNVESNEKIIWILSNLMFLLKLTNEYSSKITDHLINLQKKKNKEKISNQVEIFKELVVNLLNRICFRIFEILKKDNESKFEVIFSKNPEEELKQKNDLSLRNLATNQIVDSESSITQNLNQILDISNHYFLDHELIESIFAYYFEFMNNSISNQILQTPSLCSSSLGFYVKLIFAQFDQWLKNNQFFFCCEKFLMIKQIADCLVMKKKIISDFPNDYSVCSEICPNLSKNIIYQILSNFKPDELDLEPVGKFELEQFSLYYKEKSKKDIFEHPKKFANQNFLTFNNQKLNFLKDLENIGFLDNVDYQNWDKFEIPEEIRQEESIQFLNFSIKEIFEKSNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF37</accession>
    <name>A0A9Q0RF37_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adiponectin receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF37"/>
    <dbReference type="OMA" id="EVPSWYA"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5078461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="369" mass="43092" checksum="0503581E8693229D" modified="2023-09-13" version="1">MNLEITQEEKGEIIDNNKELKNIETKSYDQQKDPLIFNNDKKKNKKKKNKNKKKKNKNKNKIKLKKQGKLDIEIGIGIDNRKSNLEAFANVRIGRNNSFILFDADNVPHRHVGFTKFVKTGYRMNFNIALCFKSVFKLHNQTLNIWSHFLGFLVFIGITIYIYSSKTPVTTSKTNEIIMGVYIAGTLLCFSTSTIYHIFECYSVKAYKALFIVDLTGVIVMIETSYLPIIFYNFPKHNFFRNFYLIIMGLLGIFLIYLIWFQRSFMDSHPYFRTFAFFGVCGFTVVPLIHMLIIIPENHAINILWRVLVVLLIYGLGCVLIAFQIPERYSPKSRFDNFGSSHNIWHFCVVCAALFHFFNCLYFMEDPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG48</accession>
    <name>A0A9Q0RG48_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA cross-link repair 1a protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG48"/>
    <dbReference type="OMA" id="EYRSIMM"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="210"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="508" mass="59833" checksum="C23E518AB6E8D7F1" modified="2023-09-13" version="1">MIQIPKENQIQGTSFIVDGFRYKDESLNHYFLSHFHTDHTIGITKNFKKNIYCHWKTKNLLVSLKGIQPNIIFGFEYNQSIFIDNIEIQFLDANHCPGSCMFLFKFQDGKRIFAFLKNESRIDVLYLDTTFCDDSKSIFLTEIEAANYILNQILEIQKNCEKKDLKFLCLFGTYTLGKEMVVLTVAKNLGYKIYANPRKYKILMLCLDEEDKKLITQDPKQTPIHFFDMNKIRFDLMRKYLQEINQQTQTKIIGFKMTGWSLDSKKSRNSIQNIRIQQNAENMIFNIPVSSHCSLSELTQFVGVLKGIKQIIPTVNTESPKVQSQIKKMLEHKIQYDIISIIHSKIQEKQKQFKIEDSIIKKEKSKKKRSKKTQTEKRKTLETKPKKFQAKSQQNFNEKKGLLNFFPISPKKIDIVCLTQPTAPLKKPNIKGTQTTLFQFYPSIKPYFSPKRPKRKKKPKKNFIQKTIFDYFVREKNQKEIVSNQNNVKKELKQLKLTDFFEIPKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG55</accession>
    <name>A0A9Q0RG55_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sca1 complex scaffold protein scaa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG55"/>
    <dbReference type="OrthoDB" id="17150at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037474">
        <property type="entry name" value="ScaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516:SF1">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1210" mass="143878" checksum="FE251D28AC6C8C46" modified="2023-09-13" version="1">MKENDKDENQESTLFRLSRSKSEAIESFYEIPEIDSKPIPLSKSEMNFKKIKTTYYLGSDGTVFDLHYNIVKNQALNEIFNKSLEFPNVEDFNDYNSFENACIEWMKSTQKIVSRFHLPQIVGRSYFKPQENIPKNKFMIPNHKDKDETESEMPLESENTHETDTKFENENGNETGNETEKEIDLEIKIEVEIEKAFSNQNPDFSFEDEENSKEQKLKLLSIFEGRNKELMEKFEKDGKFLSQEPWHSQLFPQEPHLQRYIKFDHFSRAYRRWAQIVISSLNPVPLHAMDFESQIKLQTNKEKANSKKEESQSQLNENQSTVQQQTWRSKIYQSFIPYSLDSSPNLSLKVNRGRNNSNVCTFTTSWKEQSRWIRSTIQDSMVQIMKKTKKEQTLTRPIIGKLHGVLRGHGTSSRSFNKISSSVLMLNENLGPWELLRMDCVPIIDGESIEFFVPSYNLKEKFDLYQVKDDKEYLTKLKQQIEEIDFGNQIDSYCAWNFPSKFRKNFNLEQEKIIENVLKQDEFNYDSFWKILNTPQLFDKFVEMLDSNKFMHKKIPLKELLIEFLRKNYRKKLKECLLENQSRLTKMKIAKLIEMIFENYDFINELLSENDIQVIYLVAYSLSLMIPYCKKVFPFFPEIYHQIQIKFKDEKFLNFIHKIWIFDYLKIIYEATQSKNIRSIIKIKGLDQRSPTISSIFLYLLIQILELQDERIVKIFEKNGKQIVFHFRKAAKSKFTHTQLAAKYLWNRMKEDRFINFFTNKYVNDMDQVINDLFENQKTQKSGKPEKKESKQLNAKLRSSTILHNPLQMMDKKSQSFANLTSLIKSNEYFQPDINPTTTSSSSTLTKNQEKSANYWNQLINKRYYHRFPFLTHLFTDFFGYIYQQISKGVSIVLNDSNLLSPKIYESITHQIFMKFENYDEDLIFISKFLSEMIRCLQSLDLICAEKRTLNQKITQRKHSKNRNQNKNSSQKIQISTSQLAVFVQLIHKAPKNEYNFKINILNSLRYLLKEESIFNNFQNNISDLIPIIKIWCLDEGNAEFNKTAFKTFYQIVSYHSNSIQYLIQNNLLDFLIEILTPHYKIYVTHCLYYFSKLFSMDLIEKNRIMNHKKPIRVHEKSPIKTAKRDVKILVQYFVKKHYFVRFHIMLQKFKGKNHENSGAPFILLGKIYQIIMFSPSCSKFFRSVKKEKTYEEGFAFFKQKLIPKSKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGN7</accession>
    <name>A0A9Q0RGN7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotrophin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGN7"/>
    <dbReference type="OMA" id="AHANMIG"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="558"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="609"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="662" mass="75900" checksum="6A801B178C15EFCB" modified="2023-09-13" version="1">MGNQNIFELIETGNLKKIQAISKRGRIDFEKKNKGLPLLHFAILKQKIQIIQELITLGANVNSIGTCGDTPLHFSSKLANVNITKLLISSGANVVQNKGLTPLHYSCDNPNCCTELIKILVKNGADVNGETKTGWRPLHTASLNCSNKIISYLIGLGADVNERDYLGLTPLHYCAQSGNITAASELLKKGANINAIDINMNTPLLIACGSNIQKPFIDLLIRFKANVNAQDKDGWTSIHKAVVRRRQDIILVLLKKHADGNLANNDQKTPLQLALEYRDKNSVKLLTSWSKHQLKKKQKLDAIALKKNVLKKQVIQPTSQKKPIKTYRKASNIQRSISENDLIEIIDEKQEEDLTEKDLLEKDDLSEKENLTENETETESENENEISNEIEIENSNEIENSNENSNENETESEIENSNENDFSSEADDIFNENTDKPKHKSKHKLSLVSSQSFEIKREDSDLTDYLIDHINSENDESYFNSLSEKEDNETDENNDIETDENIQNNQNNQNNQNNQNNQNNQNNQNIQNNEIQKIKQNIQINLIRIHTRSKSQTENRNQFENQNQNENENENQNQNQNQNQNQNQNQNQNQNLNQNQNQNQIQNQFENENENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQFEKDQKILISNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGX7</accession>
    <name>A0A9Q0RGX7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGX7"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="290"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="473" mass="55512" checksum="67F10D5528D3F591" modified="2023-09-13" version="1">MNKQNWSKILNQEYVRDFERLMEKESTNSNFKIIVGNEKMEFGCSKLILFYRSSFFTNYLTHNETDQVFFPDISPVVMPGIIRYIYTSRITVPTKWIIDFYYAICKFQFNELRNLLFNWIMDHLNSETVLQWFDQIATLKSQPLLQKCFSIISENLPGVFFQEAFLTLKEDSLISILDQFKNSIEFSKEILNCLANWVDRKFHFSNDSQDSKYQMEITHFLSAFLKKIGVKNIDNLESIFFDKNQTLKISHNPDIMECAEFFQEMVTEYDNDGNQKLIFRSQESGIQTSKIINGSMELLNCLKNWLNKDFFLASTLCYSYSPIAEEKLLTKPDFHKWCDNKGPTLVIILTTKGMIFGGYTSVGWKNQFGNCKYFKDSQSFLFSLINPSKKMRKFPIKPGQEDYAVYFDKNLGPVFGFGHDLYVEQSIISGFSNCGFSYYDNVDSSNQQEISVQFFSSEQSYWEIQYLEVYTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGY9</accession>
    <name>A0A9Q0RGY9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MateRNAl protein pumilio</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000006">
        <property type="protein sequence ID" value="KAJ5080621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGY9"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="377"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="402"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="474"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="546"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="583"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="619"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="655"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="721" mass="83760" checksum="1EBCD828D3F4CDAB" modified="2023-09-13" version="1">MKSQKNQENGHKKSTSINFKEEKIEIGNQSINNKEKSNGYQPPQIKINGDSISRPISAPPNTFANISRISSLFPIKKDDSINKSTTLRPKEFDFRPLPKFFLEEDEVNRFMKQLKMNSEAKEESNDNLENKENYLREITKNNNKTTNTSFDSKLNFGMKDRNSNLTPSPFKPKENTSTKQNILMDNSTEQRNEQTFKTQNPLSLFSKQDVERFPKIPQTKKSNSTLSPLKPSFSMPTWAQPPQPVMSQTKTNLPPPKFTKLRKSHSTNEPQNITFFKPTNQFPPFESNVNLNQEYPPFQLSYQKSYEQSYHPNYTNTNSFSSDQGNQSPYFYNPYQNNTQDFNQFNNLTWTPQYPPQMNDPIQNNYFNGLYPQLPYTRNTGLEQSQPQQNIFSHNINQLSLSFFFGHIAELSFDQHGSKLIQQKLESATEFEREQVFKEIKSSFMELIKNTFGNYVIQKFLLIALPTHITSFLSIMKGKFYEISTHIYGCRVIQKLIEISNQEQQILIASELKESVIQCVHDQNGNHVIQKCVEFIPQQIIQFIVDVFADDVLELSKHQYGCRVVQRILTYCSGSKVDFMISQLIQVVPTFVFEQFGNYVIQNLLENGTTEQRVEIVSRVFGKVLEMSQHKYASNVMEKCIEYGSQEQRKKLLEEILDNEGAALKIMMKDQYANYVVQRFLNKLKGKEQQKIIQFLTPYIETLEKASYGKHIAAKLKTFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI44</accession>
    <name>A0A9Q0RI44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Placental protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI44"/>
    <dbReference type="OMA" id="NDRINRP"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="249" mass="28478" checksum="AA64D76706F79AE8" modified="2023-09-13" version="1">MQNNIFSNIPVFTKIISILIGVLALLNVFSQETENYFALKVGLTVSPNYFIWNFLTAGYFEISVIGAFFSIFLLIVTGKILEPLWGQKEFFKFIFIINAVTGLGTFFLIFFLNIFIRSKTILYLPFCGFSGITAGFTVAFKQLMPENEVSFVFTTVRVKYLTGIYLLVSTIFLFFGAYQQYPFILLGIYFKTAHPITEKIINKISFWKNDQNQSGNVTGYLSHDSENTLNTEEITKHDSDSNEDMENKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI45</accession>
    <name>A0A9Q0RI45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nischarin related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000010">
        <property type="protein sequence ID" value="KAJ5080473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI45"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="740"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="383"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="566"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1152" mass="135109" checksum="24EEA1C0AB89BD1F" modified="2023-09-13" version="1">MSQIDLLNDSIETSSQNQIEISQETQETSQIEENKLNLHFKIYQTLKNNWNEYQKGEAILPLTLNEIKYFEKKLFECEKLNPEQFENQNEINTNENIIGKTLWYLSQIPSLKIHSKNRKQKDQITNITLSEIFPTVKTLQINNCILNNFLDFHSRFILQLESLTLDDCALNSFKEIFYVESQEGLKLKSLICINNQISHFEESLSILKNLEYLDLRGNKISNITGIENLDVTYLYYVNWSFNQLYSTEELNFYLGNIQELYLTGNKLETTEGIRKLFSLEILDISRNKIKSISEIEALQSLPSLEYLNVELNPCTNSELFRVKIFYHLDRLVLLDENPMSKEEEELVKFLVKEKPRKGGSFSSLHLSPPKKSTHHQIESYSEVKDLETVCTQIEEKHREERQAMRRKRKTLESIVDLLEKWQRHKRSAEIHDSMCNRFDVRTETQANYFQELSIRNQQIDLSSFMEDKEERILHEKMRQYLDKRQKVEEEFSAKKDHGEDSSLDIGTEYFENLEKLRGDMEREILKRKTHIGSFKSNLTTSDPKREADRFESEISLYKKEGGEQWLRILNEKKKALAEQMQKLRKKQEKNLELLRRSIELGLFRSRILVEVVDPSQRGTVYRVLKFSKKTPQLFLELDTATMKMERKLDATALTHIAVAQHLQRLVVTLTFEEATKIGHKLVVIYALYDSDDADYLVSFLGLLSCTKTVENCIQCENIPQNLEQFGINGFERFFDIPDKTAQDSQSGNKTTGHRSGQIGDGNRPETTTKWANDTQLDSTDPNLQKNQMQKTRSTMESLTENDIAIENMGEKLRIVKKYDRNFERGDRETIFLFGSRFIDSYMDEELVSKRANPQRRVQNIDGVSSSKLSHDSAHKILKYNDVVEHLSTGTEPSGFEIRKDELEYISSTFFLSPVGKETVIKTLVATYVRSNEKRPSYLIITSENIYLLRFDKRRSNKKFQVVFAEPISKCVGFRIGFQSQYFLIVFDSKHPMSFLLMTLSRSITESFFRDLDKLLLSHSKQTIPVNRDSKTLLDLFHEKLSRKKRKSNLFSISKDNTNVLYLYSNQTPQKKEDKTLSRFDWPLSLFSKFFQFNQETHIILFAKAVEKIRILWKKNKKTTLRFVSPSERLVFVDFIRHQFIRKFQTPISVLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI73</accession>
    <name>A0A9Q0RI73_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_14008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000008">
        <property type="protein sequence ID" value="KAJ5080563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI73"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="188"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="7">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5080563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="431" mass="50482" checksum="8062F8F48DD1975A" modified="2023-09-13" version="1">MIDINLFRKENRRNLSIIKNSIKKRFENETIIDLIIEADENWRKSQFEMEQLISTQKYLSLLISSKKKNKEDFQDQIQEINLLIPKKIEAEKKAKELKEKLDNLLRKVGNIVDEDVPFGKYSDSNKIIKIWGEIPKIQENQKNFSQLLLQIDNGFNQEKANIISGKSGYFLKGFPFLLSQALINFSLQFLMKKGYSLIQTPCFIKKKLIEKISGNEDYENSLYHISGNFQDDLQEKFLINSPEQPLIVYHQKEKLIPENLPLKYAGFSTCFPKKEKEILQVEQFEQIEQFLIVSPYSNLSEKFQQEIISNLEEFYQLLKIPYQVVLVCSGQLDQASSKRYDLECWFPSFGQYKKLGYCSNYKDFYSRKLSIKFGKSKRKKKQYVHMLNGTLVAIQNCVCCIIENYATEKGIVVPEVLRSFIGEVSFIPFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6T7</accession>
    <name>A0A9Q0L6T7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-glutamate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000142">
        <property type="protein sequence ID" value="KAJ5066465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6T7"/>
    <dbReference type="OMA" id="NVPMYKT"/>
    <dbReference type="OrthoDB" id="10262538at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2040.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2040.10">
        <property type="entry name" value="PSTPO5379-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003969">
        <property type="entry name" value="PRK05463.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="D-Glu_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="254" mass="28916" checksum="03A500F3334577AF" modified="2023-09-13" version="1">MFQTPKELRQEIRKGNFKKPTSGLCPGYLQANLVMIEEKYAEKFEEFCKSNKEACPLIDITETNKYESKLAKNSDLRTDLPKYRIYQKGILIDEVENVTQIVENYKMRCFLLGCSFSFEDLLVQEKIPVRNIEEKKNVSMFITNLDCVSVENFNTKLVVSMRPIPENLIEKTIELTEKCGIAHGKPVHIGNPDKIGIKDIFKPDFGDSVSIFENEKPCFWACGVTCSLAALSIKSDLVITHSPGHMFVTDSKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6U3</accession>
    <name>A0A9Q0L6U3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein 8a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_03491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6U3"/>
    <dbReference type="OMA" id="INIMNGS"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="54"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5066158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="162" mass="18708" checksum="6F5258A5607A620B" modified="2023-09-13" version="1">MNSDSDEKMKSEELEQPKDETRQKRKQTSSFRHNFSVKNPEIKQVTPTKSIEGWIIFVTNIHEEAQDEDLREAFSEFGPIKNMHLNIDRKTGFLKGYALIEYSEYSEAENAINIMNGSEILGRALNVGWGFINEPLRELSSKRKQGGIMDIDIKRPKSDKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L701</accession>
    <name>A0A9Q0L701_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L701"/>
    <dbReference type="OrthoDB" id="75419at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="536" mass="62237" checksum="5CE7153748997E57" modified="2023-09-13" version="1">MNFFSFDQQNNPVTKIFPEFEGFLTPEKDQFHTLLYNFYSTSAAKVVIDRKIKEIKETSERQESTLWRMESRSQTQSKYCHGNHLTASVTYTVAIYDSDVAMKLNQTYSQLIRSCHTELCEITTKVETTEAKVALYLQRVFQGIPFKSLRNDENMNLQFIQQLRSLLINLFFFERLAIETGEVYYDKFNNSLHKWINTVALRLYEIGSNNQMLFVFFHLLTTPHSGKWSKNLIYLQDNFDYDQMSYLKTLLKFVVNPLIKSKTLSDKPFYLLEPDFVHHLSNLPFSNFFGYLFANPGELGFSVASEIVQEFVMILIEALVRFEKYLDFRKTIADLMFHFFWLYDEFSHHINTPDAARDYPKIIDELTTISIGRVSACQDKSILFYFTDLPFYSLSVFAGFRIMSLFFTGSDQNPPQNPEQWYQLMNSDPSLVSRFGSLLQSSNGGESMLIILANLAVLLNSPDFALCVVDLIFRVSCVVDTTKDRIFPHGKKPLQQSPQNIPFWFQIFSLSLPNILVLSVLAVWIYLVLFLSPNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7E3</accession>
    <name>A0A9Q0L7E3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase faf-x-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1281"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="838"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1535"/>
            <end position="1548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1548" mass="184578" checksum="D7F29C7255CBD16A" modified="2023-09-13" version="1">MENQIKSSFRETKYQFFDENLEFFDSINGFQGLISRLLDKTQAVSAIRIKMLLKPIYFNYKYFDESLQIQYLLPLIELTDMIINEKYEQLRNQSKQSLDEIIKIVFEMQSPFNSDSKKQFENAKITFSFRYLNSPFLEMKVIGINEISEISRDISRTKKKIIHLSKIEFFKKMKENNIMDILFGKTLHAELVKRSHYTLQFLAENGYIGKKELNQIWNATHGDKSTNEAVFDSLLWITPKISLELKEDLFQKINQITEWNEQNVSFVFQFATQMCKRKKQCSFKPIQKVWNLLNDKFLDQNLRILLFGNFSSFIDDNCSQKVCQNIFIYCLQNIQSEKAATFSFVFIINIMKKFPFHEKEMKFLSTILSHFEKSIEINEKNNMENLNKKNIQNIDFLEDCSRSLKLDFLFTILKQFLSLRNIQESKNLVQKLYEIFFENTKNQEEKDNFLKWILSIQQFILNSEITYLLFDKSLKLEEKTMTINQYEFFKFFSFSVNFNNKIIQGDLEQFIVVGIPDKTFLQSVEKIWEICLHCDDQQVLTKAASFLIQFQKYPNFCLNQKRKEFLDRCMRYFLQVSDQEIKYRSLFIILKFIEKTEKFIDPDFLEFQRHLFLLKESPFDITIYIADQNFTMKFYLNDTIHHFKQSILHQIQQKFICKNQLDFGDIPETAKILSETNFFFSRRINLKILENAQLSNIHHEKNPIIPKSQDLPSFILSEYSGALLDNLDETRIGQNIWKLLLLIPTNEQVLRQFHSINDIKNFPIQQLITDEMISSESFFKILYFLRVIDYYILNQGMKTNYKLNLNSISNSISVGKIEQNQNENIQIEIINENEKENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNIQIENENQLSFSWNTSFIQTNGLHQVLKLFFYFTEKEKLKQTQQQEILKNSTEKVIVMTLKIIYDIMSDDSITSTVINTIKNFQPYTPKQFVHRMYDTIMEFSDNTQNSNDIIQLTDLITLCSQIMHILISSQNLIWIHYLQEFPSFSDWITKTLIIQNSALIHAQIYNNISNILKQYLDCISKDQEISQKENTQKQEPFGIFCLRVFFSKLEEIDSVTQVEITAQYHHFFAIFDYLIFYCIELIPKMPNFRTVIVEMINKIYNSIHQLILNRKRIETNFQIDFVLLNYLEICNKIVIKFSQSKIKSKINSNLLQAVLKICLFTIPSQKNQKYSKCLTQKTRHTAYKLLQKFCFKNFSSIIDVVKFLDPLQEKIEIFSGNWYYNCRAPYFSRPKYIGLRNLGATCYLNSIMQQLYMVEEFRRGILQIECTTKSDPLFYHFQRILTYLDQSIRSDISPRKFSKNFKDWDGEPLDTNIQMDAEEFLNRLFDKLEEYVKKTNQENYFREIFGGKVENKISVKQYNYCSKREEPFYTISLDIAKNKTIEESLKQYTEDELLVRDNQYYCEELKKKVDAVKSISFTELPKILIFHLKRFKYNLETQRRYKINSKCVFPMTLDMESFTKEGKMKASPNTNENAIENENQNQNQNENKNKKIKNENQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8V1</accession>
    <name>A0A9Q0L8V1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8V1"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="341"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="703"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="921"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1030" mass="120508" checksum="20EED725FE745E84" modified="2023-09-13" version="1">MSQFKQNRNAFQNSQKSSFIKKSPIQNQNIKNSFSVKNTNENQQKSSFPRRKFSVSKGRIVLDKSKNEKSTKDNLKNKINEKFNRPTFSIAQNQNSNQVFKSVSPKKFAVEKGNQNQKQDAFSNQQNQAMKFQKIKNISPNKNEDSLNNPKQTNQIRFPKPKKKMFDDFPENNIPNDALNKQQTKTQMSRIKFPQPNKNIQYSNQYYQENSENQVSKETRISNANSPSPNSNFGNETTSKQNISNKPFSGDQMKSERQSINRFTRQINFPKTNQENSPAKPTSPRAHQNTNIFKKPKSNLQRNVSVAQPNLRASLYPLQKSFSLKPEGDKSPKNVIQDDSQMQPILKIILEEEQKFEKEFDEIINIWKNPLLSLSQHKEEFESTFSIATRFIIQSKQLSEKINLYLNIQKQSKSTETIIDTLKGINFELYSQWDQQNTVVHQIIQDLEKHNEPYRSVVAKCSHERIGQDFFHVLLFPLFYIRKFEENLKRLSSLIPPNTSVGSKISKILETSGNIIRDTNSNFWIFQKRSQLLNIQKQMGNSPTHIMESSRILNMHGGFKRVSRTKNYQGQYFMFNDMILLAKQKRKSQQLSYDICIFYSKSKIRDLSDDKKGQIQHAVEFLVEDNPERFICCFESEELKNQFWEIITSKLGISIEETSKTAQSTEEIIKKRKELSVMNNPIQQSKTSFQIEDFQGKTTDMNMRANVIQELVQTEEKYVKDLHVIIEYYLKPLREKSIVHKKDISAMFSSIETIFGVNSNILQELQMLYQKDPEKVAEMNVGTVFQKYVDFLKIYTQYCSNHPQSISTVVKYSKKDAFENFIHHQKENVAECGGLGILDLLIKPIQRICKYPLIFKELLKGTDPTYPDFQDLFKAYQALYHVAEYVNERQRSAEQSMIVVEILTRLAGIPKSFELVQPTRQFIQEATLKKKSVRRIQERQFWLFTDVIVYGKLSWTSKKKKYQYKGHLYLAESYVREITSEEFAFQIFPFGSKKGYTIYCNNEEQKQDWENKIKEQIKRLAELGIRPKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9R5</accession>
    <name>A0A9Q0L9R5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Intein-containing DNA polymerase theta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9R5"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000002">
        <property type="entry name" value="DNA polymerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.10">
        <property type="entry name" value="Taq DNA Polymerase, Chain T, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="DNA POLYMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133:SF62">
        <property type="entry name" value="DNA POLYMERASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="1">
        <location>
            <begin position="545"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1165" mass="135974" checksum="F7E088484586644F" modified="2023-09-13" version="1">MKNLPFSNFKNKTQQIDQTKSIYFQQELKPLVAKVETELILEQKTTQQSFQTIPLEDSAWEFLLEQVSKAKTICWAVIISQEETTFRKRKIKKPRGRKRKEESVEIKDKPGLINPKIVLLIDSELKCLLSFDKFRKLVENVPNSTLVALFDIEAISRALFLQKIPKTDQVPFDLKIACWLCDPSLEQYDFDNLAKIFSFPDIETSTKNEERNEEKNDPKLTQEDLLYRLNAAGKHETEKLKISEKLRSLFLSQIGFDWEDLPKIKEQEQFDQLRDQSFDSIREEVFGDLLRTEKAKNKICEKLLALGLLDTFNQFEMPFAFLLREIESKGMLFDFGNCVEHTKKLDNELEEVAKQIYKEAGHKFIILSPVQLGKVLYDELGVLEEQNPKESNKSTRNKTKTLRTTSEEILSCYADAHPIIPLVLKYRGIQKQSATLKSLLKSAQEQTRLRIEKQALQTQNQSLSPSKVKIDLVTPIATPNSSSNAFQKLIQERWKKENPEKQEPNPSEKLQRLSTIRIVTNLSQVGTSTGRLTSVSPNLQNITPALRKFFVSKPGYTLMSVDYAALELRILAHLSNEPKMISILRQDDVDILILISSEILKKSAESVTKDERAMIKRVLYGYMYGMGPTKLSHTLKVSLDESKELIKNLNDSFPHLSNFRESIKQSARSLGYTRTIIGRSRPLPNINSTNHNKRSQDERISLNTTIQGCLYPKAKIWTSQGIFSIKKLFQKFKNYQNIKVWDGYKFQFFQALQKPKQITIKVEFNDGTSIWCTKDHPFLSFDFETKEYFWIKAKNITKKSVLLFSKQGLQNGYLQNEDNNFNFNFNMNSKILFWYLFGFLYNCEMDADENDLFFKFKSKKSFQHCLSIFNKLFPKSNLKNVQNDNNLLQIHLKRKFWEKFFFNSNCILFPERIWKISWKERISFFVGFAVSYFETINNSINYCEAKMTFKFAKKKNFELNQLLKSIGIYSFFEKNQIGKFRELKVILEKNKIKFKELKEMVYSSLFEKNYEIFIENIYGNFVTFKELSEKQAKKYEKSSEISNLFSHFYIVKGIISSKEKIQETYDLIVESKFHGYCANGIIVHNTSADIMKLAMQLVNTEVVKKGYEEEVSMLLQIHDELVFEIKNERLEEIREVIVNVMEHVVPFQVPLPVRTKIGKDWGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9R6</accession>
    <name>A0A9Q0L9R6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9R6"/>
    <dbReference type="OMA" id="IMIMIND"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="133" mass="15378" checksum="4205230A822D6422" modified="2023-09-13" version="1">MTNPIKENVLIPLKNSNDNLNTNLNDKETLKNEKLIENNIKNFSNIIDNDNDIDNENDNDNDNDNDNDNDNDNDIDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNENDNDNDKMIMIIMIMINDNDNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9S0</accession>
    <name>A0A9Q0L9S0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9S0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="144" mass="17307" checksum="0F9B72AF0B7CFE50" modified="2023-09-13" version="1">MKQKMDLNICIYFEKGLPKFGEIAKIKHLLFLHEKLPENFDFYLENCPQKFKKELTTFQIEVLKASFININTYEFLKVLKRLIRNIHEGLISQNLMKNFLLLVIKDQELEIYNQIDDYFDKKNIIYLGNCIPLYNFCSELILMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9Y4</accession>
    <name>A0A9Q0L9Y4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9Y4"/>
    <dbReference type="OMA" id="HYNEFTR"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="329" mass="38312" checksum="6351527F642C713A" modified="2023-09-13" version="1">MFTKKNPINIVKNCQKLLLNLETNETKKTNIKQIEKIINDLNSISQIIFGSEKKVPNPQNISVLADEVFSSNFMIQLIQNLSKFPFEVRKTIVKIFEFLLFQKTQNNKLPTEYISEKFLTILFEGYTNEITSINCGMMIRTCAQDESLAKNIFLSKNLETLFESVESPSFDIASDAFRTLKDLFTSNKNSLSNFFVDNYERCSKIFKQALQSKNYAAKRQYLELISFLIIKSPIKIMLKYFLDSEHFLLIISLMLSESQSIQIEAFHIAKFFIMNPKRNDNITQILVNQSKQIIDFLQNFSVQEKIKDETFEVDSKKVLQEILKMNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAC2</accession>
    <name>A0A9Q0LAC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAC2"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF28">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="662"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="883"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="930" mass="107576" checksum="7D88A233F0870136" modified="2023-09-13" version="1">MGSSPSKSNPNSKSNSNSNSNSNSNSNSNSNSNSEIDLKIKKDIEKKKLIITKQQITNIPSIYFNDFDKKQVQILDLSFTQLKDDSLISILALTELKELYLKSNNLTNLPKNFTKKLSLLEKLDLSYNNFANIHDQLSPTLKNLKKLNLKKNGLQRLHPGICHLTSLIHLNISQNMELSGVPNSIGNLKNLKKLKVSYCFLTKISPKIELLNNLEILLLNQNRMNSFTADFSQNKNLRKVDLSFNSIQSALNVCKIPQIEWLDMSGNKNCQIPKEIANCKNLKTLRWNNADLKEIPEEIAQIKDNLQELRLRINLFQEIPKIIFQLSNLHILDFTRNEIKEIPDEFSSSFPNLKELSFAANKLSIIPLSVFRLLSKPLERLWFDENPLKKEYEDLLSKGMYPLLKFIFETNDEPTIINDETQNQIENEIQIENENQNQNQNQNENQNENENQNQNQNQNQNQNENENQNQNQNQNQNQNEIEIQIQIENQNQNQNQNQNQNQNQNQNENQNQNQIQNQNEIQIENEIQIENENQNQNQNQNQNQNENEIQIENENQNQNQNQNQNQFENEIQIENQIENQNENEKKKDFRLYPFTKSKLTNEQLRDKIKGLIIGNCIGDAIGLATEFLYKLESMIYYDYNLIEYKSFVQDRHRSKWIYGDWTDDSDQLILILQSYLANNGVIVPTDFAKRLLFWADHGFPELGDQYGSGIGATVGDVLEHKDFLTDPHKSAHEVWIKRNKNAAANGAVMRTSILGVFNFEEIEKVVENTIKICKVTHVDPRCIASSVCVTTAIAFMLQGEEDLQKIIFNSSKIARHFLDLKTHLQEFDFYMNAPSWKSLALDERKSIGYTYKALGSGFFGLRNINSPQEFKQILTELTFESGDSDTNGAVLGALLGCWIGFSNLPKDWVQMPHLDWLEEQIDSLFKFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAF8</accession>
    <name>A0A9Q0LAF8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 10">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_11762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 10"/>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAF8"/>
    <dbReference type="OMA" id="INMMYAH"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01570">
        <property type="entry name" value="NAPRTase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="304"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="409"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5069277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="534" mass="60066" checksum="2BE0EA1CC37AD509" modified="2023-09-13" version="1">MSIKVTNSLVTPLLTDKYQLTMAYAYWKSKKQDQKSVFDLFFRVNPFGGEFTIFAGLSEVMKLLPNFKFTEDEIDYLKKDMVGCEDGFFDYLRSVDASQIKLYALNEGTLSFPKIPLIRVEGPLAISQLLETPLLNLINYPSLLATNSARMKMVSGHKKTLLEFGCRRAQGPDGAISASRYSYIGGFDATSNMAAGKIFGIPTKGTHAHSFVSSYLTFSDIKNPILKDSKGIHEVNFVDFVLQTRKETGFTHTNDSELASFIGYALSFPNGFLALVDTYDTLLSGVPNFLTVAYALHKLGYKPTGIRLDSGDLAYLSKETRRMFTEFGKKFNADYFSKLTIVASNDLNEESIIDLNKNHHEIDVFGIGTHLVTCQAQPALGCVYKLVEIDGIPRIKLSNQLIKVTIPGKKEAYRLYGNSSRSPILDVLVKTDSTQKPKVGERFLCRDPSLESNRMILSPSKVVPLHHCYWDGKQAKEVPQIGSVRKYVIDQIHEMNPSHFALKKPLPYKVTLSDELYHFLHDLWIKEQPPLEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAP1</accession>
    <name>A0A9Q0LAP1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAP1"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="491"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="610" mass="71086" checksum="30534269B4470C82" modified="2023-09-13" version="1">MNEIIFFGSNNYPKLIKNKSYLIKKPIQFKFENENENENENENENEKQIKQISSGDFGTIFLFKNGKAIEYLNENNPNQNPQKIQIENIQKVSVGYENEAILTKEGNVFAKGKDINPNNSKEFINISSLIEDTNDRIIQDIISGYSSIYLLTSNQNAYGIGSNYYCKLGLDYETLKKTEKPILMMKNVSKIFSGITSSYVFILNSNQELFGCGLNIYGQLGLGESRKEETTINKLTKIPNIPKGKIIDIKCGYSHSIMLIKDENENPKRKLYSCGYYIPNGLGKNQDTYEFTEIKSSLFENDDNILEISVGYSHTLILTSKSKLIGFGNNDYGQLGTGNTIDQITPIQIELPKLRFNEDISSYHISCGSDKSFLYYSLSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNEIEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYFEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLIKKFNNQNQIGKEKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBB6</accession>
    <name>A0A9Q0LBB6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBB6"/>
    <dbReference type="OMA" id="HGCWALK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="399"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="440"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="483"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="525"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="613"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="687" mass="81341" checksum="CC230468E8AACA7F" modified="2023-09-13" version="1">MKNNKLNFNQSFQEESELNSNLKSNSIKKTIYEILIKIQEKKQITKEEIQKIEKTQLFQLFPSNFFVDLLDEKMGKLKSISENLTQKETKLNQKQQKLNQKQQTLEEKENDLNKNKTQLQKKENEINQKQQKLKVKENENLQKENEINQKQQKLEEKENQINQNKTKLQKKENEINQKQQKLNQKKNENLQKENHLNQNKIELEKREQKIQEKENENLQKENEINQNKIELEKREQKIQEKENHLNQKQQKLNQKKNENLQKENELNQKQQKLEEKENDLNQNKTKLQKKENEINQKQQKLKEKENDLNQNKIELTKRENKPEIEERKIQINLQNFREQKEGKISGIKFEEEINIEKTIQWMKEFQLNEKIQQNGCFILHNFSVGDHENQIEIRIRDGISTIIKSMNNFPNNEDIQNYSCRAFINISVNDKNQIEIGKKDGISIIIKLMNNFPNNQDIQKHGCWALNNLSFNNENQIEIGKKDGISTIIKSMNNFPNNQDIQKHGCWALKNIAANDENKIEIRKKDGISTIIKSMNNFPNNQDIQKQGCWALSNIAIGNNENKIEIRKKKGISTIIKSMNNFPNNQDIQNYSCRAFINISVNDKNKIEIRKKDGISTIIKSMNNFPNNQDIQKNGCWALSNIAANNENQIEIKRLNGNELIKKAMNNFPNNKDIQEKGNWTLERLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBJ5</accession>
    <name>A0A9Q0LBJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetraspanin-8-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBJ5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="141" mass="15339" checksum="0452388872792958" modified="2023-09-13" version="1">MLSYWAGIHLVVGAILATIIAAPCIGVAATDRNKDCPKSLWTWVLICNIGIYVSLIPTLFGMFTESAWAYLVVCTIPILFLFIWAIIGLAWAKSDGVKDACGRLYDVTFGESIFLVIAYPCLIFLSYCGVLLVLNMPGPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCB3</accession>
    <name>A0A9Q0LCB3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCB3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="345"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="523" mass="61996" checksum="5C3FDF059A315B98" modified="2023-09-13" version="1">MDNNNNNQIENENQNENENEMKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSIFLNQFNKKEMESILSYIYYGNISFDNQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRDLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNERLKGKKEKEKEKEKGIENKRLFHSFSSLFDKDSISKQDFDKLKQFDFFPKSFLVDIQNKIIQDNQKEIENKEKQNQQMKIEIEEKWKKENQNLKAENEKMKPIFDEIEEIKKQFQKIFSDSEIMKDIEYVKKLQEWINDNDFFSKMKKGFSAKINGFNSQNWHKAVDGKGKTLIIIKTKDNFIFGGFTQVGWNSEKSGCLTDPNAFIFSLRNDKGDRIPAKFTIKQGEEQYAIEYLSDWGARFGGGADFAVKSNLQSGYSNFGRSYNLPNLITYGTDEAKSYLAGSYNSWVVDELETYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCI0</accession>
    <name>A0A9Q0LCI0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 11 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_10681</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCI0"/>
    <dbReference type="OMA" id="ENENECP"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="387"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="637"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="886"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="840"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5070611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="988" mass="114140" checksum="29A8DD89C19F3E35" modified="2023-09-13" version="1">MLHWRRFQFFNKEIVQDPTTSKPTNLLKELSYTCCSSGKGRLVFGDSSGLIHFVNRQFQIYESFQAFKNNISNIYQLKQSNILISIGQDSETEHSPYLIKIFNLEQKNKKGVYPILKELKIYSGKYPNVKVSVLAVEENLTKIALGLENGAIVLIHGDILRDRFSKQKLIRNPNLDLVTNLIFLTNSTEIANQNEILYCATNQSIIAYTLIKGVAQENILDINGSKKDCTALSQNGNLIVGRDEAVFFFTPDGLGPCYGFSGEKTFIYQFKSYLLTITKGEKVNSIYFYDLKNKHIAFTTNMLTDCKYILSEWGDLYLITSDNSIVKLQEKTLPTKLEILFQKHLYNIAIDLANSQNYDPNAIADMFKKYGDHLYSKGDFEGAIDQYLHTIGKLEPSYVIMRFLEAQRIQNLTKYLQVLHQRGHAQSEHTTLLLNCYTKLKDLENLEKFIKGKSDHETDKKEGEKKAELQEEEPTFEIEPAIRALRNAGYYQLALYLAKKNSEHEICIQILVDDLKDAKKALEYIKTLDSKNSEKLIKDYGLPLVKNLPKETTELIIGLCSESIQAENDSHFFENDNSSHRESLTAVDPLSSGLSQQRTSDVMETILDNENDQENFWDLDAQKEKLFAKPKKIQENKPRQYDHQHSSKPEEFIHLFVEQPIYLVDFLETMISKRPDSSPLVYNTLLELYLSDDIIEDSQTISKEEQKKQNYDKALAILKSNQSNYDVEQALVLVQMHNFQEGIILLLEKKQLYNEIIQKYIANNEDEKLMRTCKQVSENDPNLWLKVLEYFCSKSEVEESKILDVLEEIEKQSLIPPLLVLQELTKNPKITVKIVKKYLIKQIESEIDVIEKDQNLIEKTEKKIKETKESYQILKTQPKIFQQTKCSICSNMLDLPLVHFLCGHSFHLRCLTENENYCPLCQDSMSQIDDMKNALIRSNVEHDEFDKLLKNSSDGFEVISGYVGRGLLTKYRNKKLIPTRNDYLNLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCR7</accession>
    <name>A0A9Q0LCR7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCR7"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="232" mass="26415" checksum="1AD7D543D2DC2BB6" modified="2023-09-13" version="1">MNDCLFFGYNQSPKLIENEPEKITKPIPFKFENENENENENENEKQIKQISSGFFATIFLFKNGKAIEYLNKNDLKQNPSKIQIEENIQKVTVGSRNEAILTKEGNVFAKGEDINPKNLKEFINISSLIEDKNDRIIQDIVSGENSIYLLTSNQNAYGFGSNEYVQLGFDSETLKKTEKPILMMKSVSKMFSGIASHHVFLLNSNQELFGCGYNQYSQLGLGKSKKKKESIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCV3</accession>
    <name>A0A9Q0LCV3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="SPCVADQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="529"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1471"/>
            <end position="1882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1967" mass="236176" checksum="23D5BE8DF5F42C88" modified="2023-09-13" version="1">MSKEKYLISEFEKEINRLDEIDNNELIKIINQSPNLTNTFFNLIITKIQKSSQKQKLQLLFLFNNLIQQNKEEYSTLFQRSITKIFNSICEQSLTQQNLQQIQDLIEYWKNTKIIDLTHIKLIEKKLKQNLNKINENSNVFHSEKYLLEKGDLQNISEEKPNDSSSYFLQFQNQINQNQLNQNQINQNQLNQNQINQNQLNQNQLNQNQNQLNQNQLNQNQLNQNQLNQNHLNQNQNHLNQNQLNQNQLNQNQLNQNQLNQNQLNQNQNHLNQNQLNQNQLNQNQLNQNQNQLNQNQLNQNHLNQNQNHLNQNQLNQNSKISINENRNFSQNLSNKSIQFTEYQQSLYPQKQFLPIQNTKNSSNLNFQQNKINQIDFFSIQSKIRSNLGIKLLKIAINLPNISNQELQFVYDCFENMEKEYALDLNQEREQIYHLLSYILDFIQKRNSQSNHLRNYQFSSDLKSVLEKLYLPVQFQCQKCGLRLENEEQAQNHKIKHKNLEQISIDQFNGKVSRKWFQHFQDWKIDLPQNLNQDQNQNQENQLNQLNQLNQLNQENQLNQLNQLNQLNQLNQLNQENQENQLNQLNQNQNQLNQENQLNQENQLNQLNQNQNQLNQNQLNQLNQLNQLNQLNQLNQENQIQIQNQIQIQNKNQNQNQLNQLNQLNQLNQNQLNQLNQENQLNQLNQENQENQLNQLNQLNQLNQLNQLNQLNQNQNQENQNQLNQLNQNQLNQNINQLNQNKNQNQNQNQNQLNQLNQENQLNQNQLNQNQLNQNINQLNQENQLNQNQNQNQNQNQNQNQENQLNQNQLNQLNQLNQLNQLNQLNQENQENQENQLNQNQNQLNQNQNQLNQNQENQNQLNQLNQENQLNQLNQYQNQNQLNQLNQNQLNQYQNQENQENQLNQLNQLNQLNQLNQLNQLNQENQENQLNQENQENQLNQNQNQNQLNQENQLNQNQNQNQNQNQENQLNQLNQLNQNQNQLNQNQNQNLNQNQNHLNQNQNQLNQNQLNQENQNLNQNQLNQENHLNQNQNQNQLNQNQNQLNQNQNQLNQNQNQLNQNQNLNQNQNHLNQNQNHLNQNQLNQIQNQNQNQLNQLNHLNQLNQENHLNQNQNQNQNQNQNENQNLNQNLNQNQNQLNQENQNLNQIQNQLNQNQNQLNQNHLNQNQLNQNHLNQNQLNQNQLNQNQLNQNQLNQNQLNQNQLNQNQLNQNQLNQLNQNQLNQNQLNQNQLNQNQLNQNQLNQNQNQLNQNHLNQLNQNSKISINENRNFSQNLSNESIQFTEYQQSLYPQKQFLPIQNTKNSSNLNFQQNKINQIDFFSIQSKIRSNLGIKLLKIAINLPNISNQELQFVYDCFENMEKEYALDLNQEREQIYHLLSYILDFIQKRNSQSNHLRNYQFSSDLKSVLEKLYLPVQFQCQKCGLRLENEEQAQNHKIKHKNLEQISIDQFNGKVSRKWFQHFQDWKIDLPQNLNQDQNQNQENQLNQLNQLNQLNQNQLNQLNQNQLNQLNQENQENQLNQENQEKQLNQENQENQENQLNQENQENQENQLNQNQNQNQENQLNQNQNQLNQNQNQLNQNQENQENQLNQNHLNQNQNLNQYQNQENQENQLNQIQNQLNQNQNLNQIQNQLNQENQLNQNQLNQNQLNQNQLNQENQNLNQNQLNQNLNQNQENQENQLNQNQNQLNQNQNLNQIQNQIQNQNQNQLNQNQLNQNQLNQNQLNQNQLNQENQLNQNQLNQNQKNQENQLNQENQLNQENQENQLNQLNQNQNQLNQNQLNQLNQIQNQNQNQNQLNQENQNLNQNQLNQENQNLNQNQNQLNQNQNQNQNQNQNQNQNQNQIQNQNQLNQYQNHLNQNQNQNHLNQNQNQNQNINQNQIQNQNILQKINSNSIQKVFKFTFSNSSNWLHSPSKIFDIISSNSNSNLNLNEKNSFKENFSKSKKIYENIDWKFEIPSFETKRGRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCZ4</accession>
    <name>A0A9Q0LCZ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sorting nexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCZ4"/>
    <dbReference type="OMA" id="VWEENAK"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="198"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="590" mass="69789" checksum="E27321221385BE0B" modified="2023-09-13" version="1">MFGLIEENNQFDSYSDSSTSSNETSQETSKESLEEDLNKNKNKNKNKNKNNLNKNNQKISEINYKNGYIDNYIDSKTEKIDQNNQNSNQNPKSSKININSKQKQISKSPQITKESKPPNIQRQNSEIENESTNKKKSKKKPIRKEEEKKKKKILKKSSSENEETKTNQLRNKTKKANKKESESKKKKKETETIEKEGIYAGISIEKAQWIKKEKKERIVFDIKYRNQETMEDKLIAREYQDFVWLMHILRSETPEFIIPTIPEKINRKQLKDEAPDSLRVFLERFLIRVATHPVLAFTSSLQTFFGVSDSSALQKQKIGKGKLQKSQQEQAFLDSKIKEYEAKNPQMDASFISTKQKEFMNISKSTEKLIKMLEELTGIKNGFSSIYQQIPEYLNELLPPIAPERKPNVFWDRLTETLNWISSLLSERSEQERQFIDEQFKDFRRQTEGCFFALNYYEKQLSQYVKLAKDFEAKRIKYQKLFGQGVKEEKAQDDLLKTEKTLEIERDKYHRICRILTAELKRFDVQHRQDFRNLFLDYSMSQFAFQRGILILWKKFVETYHQSFENDENDENENENEIENENSNENSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD06</accession>
    <name>A0A9Q0LD06_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD06"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="89964" checksum="AF7784B68AD8207C" modified="2023-09-13" version="1">MNKIKFEGKLLDEKLKPKENVKIIIEHKTLTLLTKREELNCEIDKEFHIAENQNKKGMFRFKFPEGDIRSIKFIKFGDREKFLEIYQKFKENEKKIENAKKNKSKQKEKQKESETESETESEKENQNQNQSQNQNQSQNNNNNNQTNIQYDNDSDISILNSRYLTLYPALLVFKPNEFNVVTPKEITRSRYDNKLNILYDAKSKLRLTIDFKKHHYLVQFIDRNSLKEFLVAYNSSIIDHVKESREKEKKEIENFAANAIFVSGNKDKDENEIKIEDEDEDEDEDENKIENKIENQNQNKIENQIENQNKIEDENQKNNQIKIRIPIPIKNQNQNQNENEYKIHYQNQNQYKYQNKYQKPTIIDDESPVFEPEIEYHSEQNPNPSYSKKTSEAKEISSDSDFESKFQKPKVIDSSSESEDTESDQEKLPKKPINSHEEWSFGIVNKKLEILDSGIIKIENDILFFNPKKSKEIKKPIIEIKFFTHPKQDQLARIQFDSSNSVFIILESKQERLTLMKSIEASKRRQRKLLKNSKLFPKNKSNEKIMRNLNSNLNPKKFKIEILNSKFEKTSNGTIELRDMKYILQYSSRTITGFCDETLKFKKSTSNPLILLLEQTGNPSTKFQFLSSSDRNEFFEMKRAQKKLISSIKRQNIQKSKKSLKLNSPKLNSPVVYNIQILDNQFNFLKDGKVVIRSSSFVFYYGTEKQIYSAENDSIKTFLHPNRSKIMRLDLNSKRFFISFQSEKERHDFLTNWEKVYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDP2</accession>
    <name>A0A9Q0LDP2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDP2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="397"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="491"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="69291" checksum="C4DBDEDA7321A720" modified="2023-09-13" version="1">MNEILFFGQNYNPKLFKNKSNKITKPIQFKFENENENENENEKQIKQISSGGFSTIFLFKNGKAIEYLNENDSNQNPSKIQIEENIQKVTVGYQNEAILTIKGNGFAKGKDINTNNPKEFINISSLIEDTNDRIIQDIVSGRFSIYLLTSNQNVYGIGSNEYGQLGFDSETLPKTEKPILMMKNVSKIFSGNSSFHVFLLNSNQELFVCGWNNYGQVGLGESRKEESKIQKLTKIQNIPKGKIIDIKSGYFHSIMLIENENENENPKRKLYSCGYSRYNGLGKNEGNTYEFTEIKSSLFENDIILDFSVGNAHTLILTSKSKLIVFGYNEYGQLGNGNTNKNQFIPIQIELPKLRFNEDIFNYHIYCGINKSFLYFSPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNQNEIEKLQEIISNKSIKESNQIFEIIYSNKIINPKLYSEIKEIINSNEKSEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRNELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIEEIQIGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDS8</accession>
    <name>A0A9Q0LDS8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDS8"/>
    <dbReference type="OMA" id="DRTCEYE"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040487361" evidence="7">
        <location>
            <begin position="22"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="229"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="341"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="527" mass="58752" checksum="518BA2BA52AE9BE7" modified="2023-09-13" version="1">MNLKIIGFYFLFSIIFNCFYCETQKNSKNDSFKERFEKKQKIKEIKIEDENEYRSSNITNEETITSKENISYQNFGSSLFISGNYSIIGSPNATVGIRESQGEAYIFENNGTNWNQKQILIANDGVENNIFAFEVALSGNYCIIGSPYSKVGINSRQGEAYIFENNGTNWNQKEILIASDGKSGDLLGFVVAISGNITVIGAPVAPVGINSNQGKVYIFEFDGSYWNQKQILIASDGQQNDYFGTSIVIVDQSILISSPGATIGTNSNQGKVYIFENNGTNWNQKQILIASDGQQNDEFGYSISNSGKILIISSPMAKIGTNSNQGKVYIFENNGTNWNQKEILIASDGQDGDYFGFSVSVYGNFLLIGSPYSKVGINDSIQGKAYVFENNGTNWNQKEILIASDGQDGDLFGYQVSLYQDFIFVGSPDSKVGDNPFQGKVYSFQIIFEPDNPNSQAKKTSEKYWIIGVSVGGVVLIGGIIFVIIWIRRRKRRGLNKFTQILNPNENENENENENENENENQNQNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE05</accession>
    <name>A0A9Q0LE05_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE05"/>
    <dbReference type="OrthoDB" id="297375at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="478"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="585" mass="67294" checksum="9C8919715308DB16" modified="2023-09-13" version="1">MKKFNQMIFFGENKYQKLLKNESETIKPIQFKFENEIEKELDFENENQLCQISSGNHSTIFLFENGKAAEYLNQNLKKMENEDIQKVTVGFENEAILTIKEDVLAKGFDIDSNNRNKFINISSLIEDKNDRIIQDFICGARSIYLLTSNQNAYGIGSNEYNQLGFDSKSLYKTEKPILMKEKISQIFSGNSSYHVFLLNSNQELFGCGNNIGAQLGLGNDFMEEKVLLSKIQNIPKGKIIDIKCGNFHSIMLIEFKTKRKLYSCGLCQYTGLGKENEIIGEFTEIDSSSFENDDDDILDFSCGSEHTLILTKKGKLIGFGSNSYGQLGTGDAKDQLIPTQIEIPKLAFDDISNYQISCSKNGSFLSSISTFSSIENDLVTIFQRKEFCDVFFDTKNPNEKIGAHKLILDRRLGSQFDDFKELISRKSIQEANQIFEVVYGRNQIKTKEMYEIVTKFNLFEPIRETMKEIFESKNDSAKNVTIHRNGQSFKFPKILLIARSGLFKKIFLEMEGEELMEFDNYSELSDDAFEIIEYWIYSNQIKEGIEITEDIIDEFKTGTDYFQLNQAHPNLLDLLLFEFENQKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEG2</accession>
    <name>A0A9Q0LEG2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanine nucleotide-binding protein g(O) subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_02317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEG2"/>
    <dbReference type="OMA" id="RFACMRC"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="168"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5069740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="346" mass="40866" checksum="E441803E5EF887B6" modified="2023-09-13" version="1">MGSKTSKRRQKEKEKSREIDARLKEEEQRFKKEVKLLLLGTGESGKTTFIKQIQILYNEGFSDSEKELYLTVIRQNLIVYTKALINATQELRISLKSENTSIANRFLEYTQFSPQVSQDCKTLWEDEGMKTAFDRRSEFYVPDSTSYFLDNINRISSTEYHPSERDILSCRIPTTGVKSISFMVNQIPWKVVDVGGQRSERRKWIHQFDDVSFIIYVVALSEYDEMLFEDRRINRMHESLELFEKTANNEYFHKTDCIILFNKIDLFEEKIKKRDLSNCFPDYKDGPNLELATQFIKEKFLEKTKNPNRKIHDHYTCGTNTKHIQQVFNSLQTIVFEKRMTETGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LET3</accession>
    <name>A0A9Q0LET3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LET3"/>
    <dbReference type="OrthoDB" id="10691862at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="831" mass="98823" checksum="294975379ED70545" modified="2023-09-13" version="1">MISNEFKKHEIFKTICSPQEQSQPPSITIEKNTTKISETKEIQNQSILFKKRTLTKQAKLKTLFKKRLGCRKSGEEYGTQILKQLEKPARKKELIDYGIKFFPSLWDCYNEVYNFDSTKARTNFGNFLLQKNSKNHDRFIFDRKSRTYSLPEWFKEISDENSSLSENEDLMDLENEQGNVTYKFKEKKNVLKTHVHFVENSKDHFKRNSNQNQNQNQNQNQNQNQNQNQNQNQKQNKNQNKNQNQNQNINQNQNQNINQNQNQNINQIQNQNINQNQNQNINQNQNINQNQNINQNQNINQNQNINQDQNINQNQNINQNLNINQNQNQNQNQNQNQNINQNKNQNQNQNQNQNQNQNQNINQNKNQNQNQDQNINQNQNINQIQNQNINQNENTNQNQNINQNQNQNPKKKTKYKISRTRKKFISDSPECTKKLKTTIHKETSTHQLFHNEILETFLNPKITKKRISVKHTQHNKTNTTTISETNSKMNIKTKIQSNEKMKLQTNPNGDINISSNKISQIEIENENQNQNKNQKQNQKQNQKQNQNENENQNENENENENENQIENNSENENENQNENQNENPNVRITIKKQTNSSFISDRNGNETFHSLSQYQKTQSFSNYNSLLNQQQKQQNPKFPSEFQMPNSRLPQFPYMFQSQFPINMQFPRFLPMIPTFFQNNFCQFLNPFCRPSFPFESQFNSQNENENENENENENENKNENENENENENEDENQNQNENEDENENEDEDENEDENQNQNQNQNQNLNQNQNLNQNEFSPFEILKNLNLGQELFSKISEEILQGNKEIISLLKRFPTAESHQLLLLKLISYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LET4</accession>
    <name>A0A9Q0LET4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LET4"/>
    <dbReference type="OrthoDB" id="306099at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="334"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="3">
        <location>
            <begin position="516"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="634" mass="75329" checksum="571A372DE9D65A0F" modified="2023-09-13" version="1">MIKFPKLFTTFSFNNPINSNKIENYLNISTNQFDYQKKTNINESSLISKQNKGKFRSNYNQKKNLKGIELIKEKRMKKKTSLEKGNSKRINLRDDYLAIDKEMDIDNQLIQNDLNENDLIQSDLIQNDLIQNQLIQNDLIQNDLIQSDLIQNDLIQSDLIQNDLIQNDLIQNDLIQNDLIQNDLIQNDLNENDLIQNDLIQNDLIQNDLIQNDLIQNDLIQNDFNIQKKPFKSNIDKHVSLPTFDHIPNNFGSYPFNINQKIHQKIKKKLEILFEKFLNQTKEESKKSFTNFCTFQINSNQIDPNKREHLKSRFNSLSQINFANRCLTDNHLEMMLEKEKSFQKEKIQNSKIHNQNYRNKMIDSISFSCHELDLTKETFYLSIEYFERLINLIPNKISHQEKLYQNACILLAAKMNEEEVPSISLFAPFFEFDQNYDQKLIEAEKEILKIFNYKLTDPTINSFLIYFLDRARWCFPIESFPSLAKGSIDYDLVHEYSSIISHIPKKHDQLQNPKDIQFVERFFKIPKFPKDLYWIICEIINLALRDVKSLQFQPSLIAAAAFSCYFRDPKLVELITTFSQENLFQCKNWISKYDRSQRRAFKINDEFLDLIKEDEVFFHFHNVSANEFIRRFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEW2</accession>
    <name>A0A9Q0LEW2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEW2"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="795"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1135" mass="128752" checksum="AE3563D5FF179869" modified="2023-09-13" version="1">MIKFNLFSFSFSFSICFIFFLLSNSFCSRVIPSNVSFTFQNQYSGNLIPCFLADGSEVNVSISTQNTNWWYIENNVAHTGIESSNNPSTYTAINLNLSSSSFSIEIWFSNINQSNNVLINGKPSSFSTQSYYPVISIGSNTSSLLIQIYQGYSPVENFTVLTPDLSNGDYYHLIVNWEIGNQSVYLNNIKIGFGNLSQNISNVFPMDTLQFEHLVYYVGSYERILTSEEIKGNYEAGIPAWFNQSRNTLTLNDSQYSLFDFSDFYLLSNSSIYEISITSNNSNSSYYYCNLYSADSGDQIKLNYTLPINSSKINILAPIQPNQSVQCLFGYTITFVDLNYKSSWKHQSKLIIDVRNVTGGPGFYPFYFELNLSSLENQSFAIDYKDGKGNNVINFTISSPITNGIIYYNGKLVSNGITSNISSASNSGNLTFDYIMTSQNNDNSPDISFNLTLGSDSGYSRTNQITLKLNSSNLEMNKGEGNITEDDYSPINLTFTDLFSGNLSSIWEIVWIGENISNSRDGTSINEANPLLVYIRAPLYYFYPLELSFMMKNGEAVKNFTIVFDITKTYHQSTIQAICYDDCENNNNNKEFIYQGNQFMISFDIFDPDETELIIRLSLTVFEMKSSSFNETQNKMLNGSKKEIDEQLANFTIITNEGNEGAQTDYLVVNLTNTEKPEDFYLVKYEISVPQQTTSNNVNNTIPIAVGASVGGFGLVLIVVLVVLVVRRKKNEVKAPPPPDDFGPYVYGEKLYNLQFKGENAKKMESIRDLEELIFTTADSLRFISGMLKVVKVYDMDSVCRAVTYLAVHNNLFKKLIEELIKDEVEKTEQESTLFRLNSPSSKILSFYAKIIGLPYLYTILAGKIFEVYTSEKYDNIILDKKLILESRNPNKLKDNLDDNLDDNLDDNLDDNLDDNLEDNFDLQVDLVAQSTLSENISKIESLAQEFLTKIFEIGEMPNQFKYICYLLNKSCNSKFNGNSGYFAMGGFLFLRFFCPAILAHSSFGILLETEHDSQIQDTKRKILTLVSKFIQNSLNGSSFKEESLINSTAFIKKNNDNFHTFFECILSKVEKSNLLENIEMRHEIPQNVRDVSLAILHRFISQNKVALALNKNKSNSFFFLIFLIFVFKKNGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF72</accession>
    <name>A0A9Q0LF72_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF72"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="228" mass="27067" checksum="669DA8D65E3750A9" modified="2023-09-13" version="1">MSFDRDPPVSVSDSDSTVQSYNISLNVDQHSKFSAFDSFNSFDSFDSEDYMFNEINFDNLQDPEYEDFIREQKLIEELISLREGNQELKNQEKDLINSVKELKIQINKERKIREKQTKELENQREMLEYLINKITNENTNTNETQTPESSLEEIEADIATYSALLKTEYLDQQKKIIEYQHDIKQLKKNKSKISNSNQKNQRSQKERNLNNQNFDFFANRLDNFNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF89</accession>
    <name>A0A9Q0LF89_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF89"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="637" mass="72542" checksum="37385D69326DC263" modified="2023-09-13" version="1">MSLSNDIEKVEISHFPNPNQNFIPGQPFGNESIKLNITENNISENNLTVHILSLNSNNYYGKLFGRNSSETVKNETNNLFQSNYTLNGTELILDNFIINQQSIYDSFNLMIFVNGVPSNSEVPVKLCFPHQDLNLNLTWNTSIPFVSGYNKIPSQPILQITNSTGEPIQGYYAYFSILNDSVEVIDFNTGITGDILSTAPSNSSGYVTWNISFLKILYNDRINSYFWIPDCQNPTLDYYNTNKIEKDLNVSIEEFNWKFFDIPSQIFYNQPFPISPKVLVSNQNTNEPISNKYIIFQMQNSSDNTQYIDIKTEITNENGIATFSNLFLDLEEEIEEINIQFICDYKSYSQDIKIIYEPTHIQILSSARNHSQIGIPFIFPNQSITFNNKNYLGSFIVQLFSFSIPISGKPITAKLISQNSENGKLDPSTSLEITDENGIAVFNLRMESGNFGYYQIEFSYLNSISITSDPIYVQIPIQKVNLIPTSDFPNELEIGNTFSATINITFFEYFENFENISFPINIITKCSDASFSNDNIVKKPNNEMVLNNLKFDSVSGNSECLNKEGKVKAEIAFSVLGIQSNFQTILITSPDKIVVTKAIDSLKQSFLFWVLVYVLFSHLFLIQQRIIILLHFLLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFG9</accession>
    <name>A0A9Q0LFG9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFG9"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="487"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="631" mass="75310" checksum="D62BCC79237559EF" modified="2023-09-13" version="1">MNLIVFEKQHLRNENQESQKASRKLLHNFLSSTPKTTYSVTKVNLWGKFQHRILRLTGVGIFNIRPKQQNSEKQKQNLSKFCDESDFAQGQISSIHRYSEIEKVTLLEAKLVLIEFKTKHPYRYFCDLGFFLSKEIASRCSIEFYLFDRRNPFVFKTMTNFKAMNYVTQKNQYKKRIEKDFIDLTPDTNLPKKMINNENSNENREIIDLEENENLNQNENLNQNENLNQNENLNLNQNENQNQNQNQNENQNQNENQNQNQNQNQNQNQNQNENENQNQNQNQNFNRIQNFNRIQNEKNQKIQKIEQKKNLQIHQYPHSEDPEDNRESLDISSQSIQSDDEILYAQKLVINYEFYTFKTEKESYGIISKFDILIPCTLKLLSLKGIELSEIILENKLLGIMSQNFKWKILNFRRYLRINEENISNLSFKIRKFIQQIRIETIKIFKETETELENIERSYKIIERLLEEMIISPVYNKINEFIKKKNESEDQNIHDRIQKLKEKNFDYFGLPNQLSRIDWSLCSRILRTFNICKLPYEYLNVLLTTADSVFHTINTYILNHDIQRESNKLVTGDDFLPVFVYVLVNSQIENLVSISQYLIDYSDPKEMNHESGYYLTTFCSSIQFIKSSENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFP2</accession>
    <name>A0A9Q0LFP2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Receptor mediated endocytosis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFP2"/>
    <dbReference type="OMA" id="HEDINIE"/>
    <dbReference type="OrthoDB" id="206724at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF14">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="25"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1139" mass="133392" checksum="A833B872548ACAC8" modified="2023-09-13" version="1">MQKSQEKETQTQTKFFIKMNQIPRKNLIGVFLVINILETGPYIEYQYSNLENQEIDSRIAEICFPSFSSQIFQKQNDFEVLKQPQYLKTRKLYHFIILDKKKKKIHGFFRRKIFSDNLRALCILTHFRWFEIFDGIFDILESRIVLKSLKSTNKIIKAINSLTFPSPGKPFVVRTKSVDGVGFSEYRLKRPIEDSLPINHKNLNLLFKTFTPDKILQIFANILFERKILIVGKKICSIPKFMSQILRCIYPFSWQHLLIPCLPPSLAQFCSINDEPFIFGILEDNLSLIPNETLTHCSVINLSTKELTISQDLANDIKRLPQPLLNSLSSSLNSIYNEFLKKGVGNTKKISKAFLEFFKSIFLTYYRFIVKKTFSKTMFDFPSFIKSLDPQIKEFVDQFKNTKAYNEFIVSRIIAFGNKSIYQWNFEKNVIRLKSSQSPFKKKNVSNDEKNDGKKGFKKKLAKFKVALFRSKKDKNANEKQNEKQNEKQNEKQNEKQNEKQNEKQNEKQNEKQNEKQNEKQNEKQKKESNSKTKNNKNKSKSTNKNEENKKKKRSKSKKEENQNQNQNQNQNQNLNQNQNQNQNEIKNEENQNEIKNENINQIKNENINQNENKNEENENKNEENQIKNENINQNINQNQNQKRTEIDLLADFEDSNSTNESPKEKHTENEQIVRIQTMPRVETLIDYSITVEQKNGFNNYRNNNNNKDHNIEILLLDLGEEKPTQNIEIINENEMEENIQSNGLKKQNGISLINFDDNDNDNDNEDDNDNDNENYFSNDNDNDNDNDNDNDNDNDNDNENYFDNDNDNDNDNDNDNDNDDEDEDYFDNGSNSDSDYFESNESDNESNNEIENQNQNQNQLQFQNQNLNQNDNNIISNNEIKKENSKRIIKIKKTGDKKDNGTIIQPTPNIQLDLKDTKTRSQNKINEIDFLSLDTQEITQPKKSKSPNLNLNFETDFPNQKENNQKINKPTFTEKVDDFSIFETNQDFQNKQKSSIQKDLELIGIENKPKNTEKVRNVNFLEDEIINVEKNKDQDSTVIQSKPQIKQQQTTTLIDVSFNNQLISFNEKEKRKSSDLDDLKEVFESNIISPNTNTNTNTNRNSNSNLNSNSNSNSNSNSNQQKPDSFSSFDSTELNEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFT1</accession>
    <name>A0A9Q0LFT1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear protein localization 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFT1"/>
    <dbReference type="OMA" id="MQDKTEY"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore localisation protein Npl4 ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore localisation protein NPL4 C-terminal" evidence="2">
        <location>
            <begin position="239"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="486" mass="56723" checksum="15ED8A9F195E6DCE" modified="2023-09-13" version="1">MIVRVRTNRGMFRLELTEKDTLETLKKKLNLIINIGVENIQLSFDNDKKVFPISFNKKTMKDLKIEHGSLLFLNQKLEIATQTNSNENSNENPNENSNENSNENSNENTNENTKEKEKEKEKEKEKEKEKEEEEILKVFYEDFNEEFEEFNEEKAKEIEEQSLRDQMNQGKIKMPETMTYVKRVYGNNSFDVSMLEYINRQKPKIKQQEKPLCEGVEVDRTSADWFQGAIHRIQFKEPRIGILFGTFNEDDSVTVDFIYEPPQHPVNEIEVKIEENKSEMDLIIEIAHHLGLKPVGWVAAHPRKSKKYLMTSWHVTQAAKIQRRFGKLAITIIVTMNKKKKSQFEAFQVSKQTVKLLRRKRFAKSKNYKLVNFNEPVVVATKEQYSCNVHYFLSSVPIVLHDSFLKCGFPIENRGPILLNDVLSYATTNMNSFQDYIRDPHFLLAVGKFEIFSIKSDFPIICSAIEAKEPVPEGYAQILKAFSEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFW6</accession>
    <name>A0A9Q0LFW6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_01546</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFW6"/>
    <dbReference type="OMA" id="ADYMRGS"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="361"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5072531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="681" mass="74959" checksum="F9C2D56D48BB4A2E" modified="2023-09-13" version="1">MEKTELIINSIRGLCADMIQKANSGHPGAPLGCAPITHLLYSQHMTIPSFNPCSFPNRDRFILSNGHASTLLYSMLFLTTEHMKMEDLMQFRQIGSITPGHPEAHLTKGVEVTTGPLGQGFANAVGIAMAQKHLAARFNKDNFDIFNNHIYCLAGDGCLMEGISNEAASLAGHLKLGNLIVLYDSNDITIDGSTSITFTENVNLRFEALGWHVQTVEKGDADYDGINKAILEAKKVTDKPSLISVRTTIGFRSVWQGTSKVHGTPLGAENKNLFEVDKSVIDFYQEVQKKNNLKVEEWYKLFGEYRKTHPELAGELESMFSEENNNKFYTFDKEKHGDIFEYKKLLEILPKFGEKDIGVSVATRSLSGKCLNALNSKIPGLFGGSADLSPSNNTYLLSSGDFTPKNYEAKNIRFGVREHSMMAICNGIASCRIRGLVPYCATFLNFIQYGLPSVRLSAMSKAKVIYVMTHDSIGLGEDGPTHAPIETLGMLRLIPDLLLFRPCDGNEVSGAYAYALSTENTPSVLALTRQGVPHLKGTSVEAVAKGAYVLNPEVEKFSAIIVATGSEVSLAFSAAQILLKKGVSVRVVSMPAEKLFAQQPLDYKRLVFPKGIPILSVEAGATQTWFKYAHFSLGIDTFGVSAPANKIFAHFELVPEKVAEKLEKMVEYFKENPVYDTLKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH26</accession>
    <name>A0A9Q0LH26_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH26"/>
    <dbReference type="OMA" id="TRESICY"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038896">
        <property type="entry name" value="RNF170"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22894:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="196" mass="22875" checksum="E4D9E77D35ADCEEE" modified="2023-09-13" version="1">MQNSDEDLTCPICFGYFEHATQTNCGHSFCAKCILDACEHNPNCPICRSNVFALYRSYLLQKLADKAREQRPPNEQNQERTNEDLDQKIKTFNDTHSRPQGIQAMRYDYNIMTRVMTNRCNKISILAWTIVILVILYMIGPYSIIPLTKGIIGIFDDLFFLIIGVLFLHRLIKKFELSQRNQRNINVEARNRPRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LII6</accession>
    <name>A0A9Q0LII6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LII6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8526" checksum="658087103FB077D7" modified="2023-09-13" version="1">MDINQMVQILKYQKLTKQNETTTLENNKRIKEYGITDGSILNVVLAQNNKNRNFGDETFPLIEKDSGCCGCCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIL0</accession>
    <name>A0A9Q0LIL0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btb and math domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIL0"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="153" mass="18495" checksum="8465A009E0680B2E" modified="2023-09-13" version="1">MIYSSKKTYSKLYKEIRRLLKEEEDLNENMQRIYFSEKEKDFIIQREEKEIKFPKLILIMRSELYRGMFLSVTEDSSNQVNDYSELSDEAFEILEYWIYTNQIKEGIEITQEIIDELEQASDYFELNESNPNLIDLLIEEFDNQNPNENSNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIZ9</accession>
    <name>A0A9Q0LIZ9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIZ9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="526" mass="61721" checksum="237F9B443B2BC9A1" modified="2023-09-13" version="1">MKTFSNKKQQNNYIKQLHLSEKSLILLNQNRQIIEINENAIKLFGFEDINNLQNSRLSNFCPRFQNHMEMLSEVALIMITTKSFEPPNECDFQFQFIRSGNSKFWAQVHLCPLKILEENFVELQIQEIQPLEKFAQETNSDWSEAVDILSTSSTLLGQIEKFISSDDDMRNFPQEKFTQSIKSSSPFEKENQINSKKENQEQFPLEFFEEKQENILQNDSENLLKQEALFNLDNSEEFNENQENFEKNNSKNNVINNINNNNKSNENVNNTNTENIQISPNQPNQNELFKPTTFTNENFDNFENFGNFPNYLLNLQNSVNLHSFPSTLTSSALKYLVHSISDKNILFENMQNYPSFLQHSFQKSYSENSVLNKNENPSFIFQKMDQHPLLNTKLIDSKHQQIIDLIQDLEKQSKFFPQEQQEMIHNYLQAIADSSLFSFQEIKNQIILLIDQINSNRKYNQQEYSTLKGIVSQNSQSVKNNQDLLKKLEEENLFLKNQLKQILLIGKKATDINKKIIEEMNHLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ12</accession>
    <name>A0A9Q0LJ12_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Breast cancer metastasis-suppressor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ12"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="975" mass="115952" checksum="D925101C809D724A" modified="2023-09-13" version="1">MSEVDKHNKHNKHNKHKQNNKQNNKQNNKQNNKQNNKQNNKQNNKQNNKKNNKKNNKKNNKDNNKDNNKDNNKDNNKDNNKDNNNNKNKKDKQNDNNNKQKDKKKDNTHKSKSKSKSKSNSKSKSKSKSKSKSKSKSKSKSKINDNKNNNNNNNNQTNQDDNSIIKSVRIDDLTFQKATLIINVAPSTRITLDIDPKCSSSHKSEDQKTRKKYNFTLTELFPSQTYSILVKDPKTETVHKRLQFRTPDNNWVQQFNDLILKISYLKNRPKIEQWGKNYQENIQKRQEEIKKKKEQKKRQKKEKKKQQQQEKSKNEQESGNDSDDDSEDEDEDDDDDDKISKENTASPFLLFISKIQKSYDNLKQNPSKSTSILQESFTKFNFFHKTQQADNLPDTGIFDDFFDKFVTSLSSDKKVKNPINKELKELIKSINKYQIPKTKTKRYFDSQKIYPIILEESIEKTLTNQQVFRNTEAPPTQSQNHKKNVIKRLPPKINIQSIWDQFEKETQNFINKEHINWNPTLFFRYLSLKNEVIPFLEEELNENGNQNEKDKNAKKKLIQEMKDQDFDIDISEIDFKNIYESRKRKITKKNYNINKKNNLLEDKTDKNKLIKYRFSRQEADNFWLHFILRHYTFARLLIFSKQEYAFMSCFDYPKELQEKYDFNYSSWFILSYIEFLYSKKFSHNIEEQYFIQNVLSNKNLDFVAGLSSINIENFIKSKSVDEREIRDNLNVARKFLKTRHKEEVSDNEFFKEIKESEEIPSSKITKFLNTIDFNFSLKDINIGKFELVESAIKFIFANSFPIEPEIKEIIELPKNSKEYQDFFFRKKISSEIEIPHKIQPLTFNQNPINSNKEPLKLNQTDQHQEQFWFFYGKKTELLSETVDLDNPFLPLLGLKNKGYPFFESPLDAHIFADSENDFYSLYLACVFLGKVAPESSKDLYLFNSIIEKSDSQQNQIFVFERAQFYLKYKITYKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ64</accession>
    <name>A0A9Q0LJ64_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ64"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="144"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="226"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="316" mass="35986" checksum="1D6F6045234537C8" modified="2023-09-13" version="1">MNDCLFFAIEYLNENPSEIQIEENIQKVTVGVQNEAILTKEGNVFAKIRTSIFESSPNQFINISSLIEDTNDRIIQDIVSGSYSIYLLTSSQNAYGIGSNVFGQLGFDSKTLKKTRKPILMMKNVSKIFSGISSDYVFLLNSNQELFGCGFNQYGQLGLGESRKQEKKIQKLTKIQNIPKGKIIDIQYNGLGKKYGLGKSSLFEDDDNILDFSVGRYHTLILTSNSKLIVFGNNEFGQLGTGDTINQRIPIQIELPKLRFNEDISNYHISCGYNESFLYYSPFPSSFSNLEEDLIKLFERKEFCDISFKTRKWRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJF9</accession>
    <name>A0A9Q0LJF9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proteasome subunit alpha type-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJF9"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000055">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5072930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="245" mass="27494" checksum="5D7EE104E88DFE43" modified="2023-09-13" version="1">MTSSAFGFDRHISVFSPEGRLYQIEYVYTAIRAAGNTTIGVRGEETVCVVTQKKVPDKLTDPTTVTSMFTITNNIGCAMTGIRADMKTAVQRLRYFAHRFEYENGFEIPVSHLARKMADFFQLFTQHAFMRPLGLAITLIGIDEEVGPQLYKIEPSGYFLGYKATCVGQKEQEGTNFLEKKIKKETKLNKDETIQLAISSLQSVLGVDFRPSDIEVGIVEKDSPKFTLLSEELIDSHLTAISERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJN1</accession>
    <name>A0A9Q0LJN1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJN1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="176" mass="20365" checksum="637A0E7A669DDED8" modified="2023-09-13" version="1">MILLNSDILTTIMVLSFCKSKICFVFTCALISTLFGNNQFIERCGNTTLTIVCSFFGLLRYNIQPYIAPFTNRNTNDFKLIPQLDLIKSNSLHIFYSKYCKAGNNPEWRINSSTAKCKIKCAALNLTYLHLYQLDFYSIHWNDFKDRIPNNMYQLPVYLNVFVCGDIIPFCNFLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLK8</accession>
    <name>A0A9Q0LLK8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLK8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="158" mass="19003" checksum="01450A00CCFFE61F" modified="2023-09-13" version="1">MESSRIIHHNHPELRCDFCEKQYNFYVKCVNPQCNKKYCPSCVIDFVSNLRKCTCRKRPFAFLEAGVQGAEEKDLEKLSHKKTTLDELTQFEFSLRKQITDQQQKLKPRVLLSPKTIQSKEGFDQYHQQNPYTNNYQYQNHNQNLYDNQQIWNQQDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLL8</accession>
    <name>A0A9Q0LLL8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLL8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="348"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="391"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="426"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="642"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="685"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="720"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="893"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1124" mass="129921" checksum="755BCFBC1232A1DC" modified="2023-09-13" version="1">MNIFEIIEQNNIESLKQIESISEKEKEKEKENKPILHFAIEKQVSLEMIKLLISKGIKINSIDKMGRNSLHISIINNSRIEIIQYLIENGISINSTDNKQKSILYYSMIHLNKENSIEIIKYLIEKGIDINSKTTSNKTALHFACLNKNISFETIKYLIEKGIDINSKTISNKTALHFACQNPNPNSSLEIIKYLISKGININSKTNQNETALHFACLNKNISFEIIKYLIEKGIDINSKTTSNETALHFACLNKNISLEIIKYLIEKGIDINSKTTSNKTALHFACLNKNISFETIQYLIEKGIDINSKTISNETALHFACLNKNISFEIIKYLISKGININSKTNQNKTALHFACLNKNISFEIIKYLIEKGIDINVKTDTYACIRPNFQMTALHFACSNPNSSFEIIKYLIEKGIDINSKTTSNETALHFACQYNSSLEIIQYLISKGIDINSKTISNETALHFACQYNSSLEIIQYLIEKGIDINSKTISNETALHFACLNKNISFEIIKYLIEKGIDINSKTDPYACIRPNFQMTALHFACSNPNSSFEIIKYLIEKGIDINSKTTSNETALHFACLNKNISFEIIQYLIEKGIDINSKTISNETALHFACSNPNSSFEIIKYLIEKGIDINSKTTSNETALHFACLNKNISFEIIKYLIEKGIDINVKTDTYACIRPNFQMTALHFACSNPNSSFEIIQYLIEKGIDINEKTISNETALHFACQYNSSLEIIQYLIEKGIDINAKTTGWDGNRTALSISIKNQNQKLIQLLLMNDANVFKLEKRQITKEFIDLFSKIYSINQDMNKLLISNDKDNFSDYQIQSNNGFKFYVHKLILLTRFNNDNSILQRLINICQQKSKEDVRIALNFLYTGFPNFNHFFNFFSDENEDEDEDEDENENEDENENENEDENEDENEDEDEDEDENENENENEDENEDEDENEDEDENEDEDEDEDEDEDEDEDEDENENEDENEDEKIEEIFQEIGFDSKWIENKKGRKGILKDFQQLYQQESTKDFTIIYQEEKENQKEEKSIKVHKLILIIRSELFKGMFLSVQDSSNQVHDYSGKSFSTLNQFIYFLYHDEFESNKIKKENYEEFSDLKDYYQLNQNSIIDLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLV2</accession>
    <name>A0A9Q0LLV2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosamine 6-phosphate n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLV2"/>
    <dbReference type="OMA" id="GIPHEAM"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="150" mass="17870" checksum="3BF9046E4B6CC5CF" modified="2023-09-13" version="1">MEKDYDLKWICEDEEYFKQILELRYQILRKPINMKRGTENNLLDGKKETKHLAAIFEGNVIGCVSIYESNQTLKIFQMLVDIDFQKKGIGRNLIKKIQDEFKDKKSIKTIYCHARAPVVPFYEKLGFKKEGDMFFEVGIEHYKMIYQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMF1</accession>
    <name>A0A9Q0LMF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMF1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="775"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="984"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1095" mass="127009" checksum="BA0C7EFFF708E24E" modified="2023-09-13" version="1">MQFQSLSILQNLIKKNQIELIKNFLKENELTNKDLSKCLTFSLMNSSTTLQIVELLIQSGADINHRNPKSRRTALLTAIRHSSSSEIVGFLIKSGTNLNLNLKDRRKRTVLFYLMKYLRSDTLELLNLILEKGVDINYKDNLLQTPLSYAIINQQPIEVVKYLIEKGAETNILNIHQENLLHICAKYNPNVDLLQLLIDKGIQINNTTKYLKTPLSYLVVNYPKTIPEIKFLVSKRANIAKSLFSYVMDPKFFEAINFVFSLSSVSINQKNQSNQTLLHCACLRKNNIKIIEVIIQNGVDVNVKDSMGNTALHLACQNDLENEVIKLLISSGIDPSITNTSSSYALEYFHKWNSNESEEISEIMVLLFKGIDLAGMKLPRLSENSWRNLFNNNKYNSEIIKIVDQISDAYDSSRYFYRRVSIENFLIYSYKNLEVFKFLFEKSLKSKKTNYSNIVSKISNYVDSSAAIIYILESLENHPEIDIDVNTALFNFSSTSHGVEQLKLFIKKGANVNTQNDQKVTVLMRECHHYPSFSNISFLIESGANAFSRDNKGNTIIHHFCKSSTSYFQPVDIHELIQLFKSTGLDINDTNDEKEDALICSCSNFSFPDELIRYLIENGANLNSTNKSGMSAFSLYLQNKKHRLETVKLFIEKGINQKTIETSFVNWIQNKIAINQSHPLETFKFFFENNILENKQKILFENSVVLHYLLDYYNMKGEEFNDLLLLFINNGANYEVEMYQKKTLLHSICTKNSSFIPSIKFLLNLNLDVNALTSSRQTPLSLACRYATSEEIIPILLSQGANPNYPEKCIDLITKNITLIQYNSKCIEYLLWYGAEWKNQKSFNSYERKINQLFLKTYKSYQEDFLNLFKRQELTDYKIQCKDGFILVHKLIITLRLYLENESEKQILGKFLNFAFETSKKEMEIIIEFLYSGIIEMSNYEEHFQFLEKFAQNLSFPKNWITQKSAKIGLIHDLERLYQDQESKDFTIIFSDETTIKVHKLILIARSNLFRGMFLSVVDNSNQVHDYSEIPSKTMKSLIDFLYLDSCSSFENFEIEHFQKAKDYFQLNENSSLNLFFSQSSLANRYFNDKYLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMM3</accession>
    <name>A0A9Q0LMM3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Muscle-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMM3"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="12"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="605"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="754"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1269" mass="151369" checksum="EB4FF0B7C5C48C0C" modified="2023-09-13" version="1">MNSTKKIKSILDNKKIVIIHWINEILNENITEKEFANQLRNGVILCELLKKVNSKICLNFHLSPRTEFFYLENITFFIKGYFNLVSKKSDAFEPTDLYEQKNLNRVIETLYDLFLYWIKNGGVLLKNPFLKSHKNSLQEKINWKKIKGIIWIKQGNNWEQSKINILRGKLKVVILNKNEDYKLDPKTSLKEISTEYRFCCLCETNDQKKKLIFSVPSRKLLHKWIYYIRSSQHSEILYKLKDSLLNFPKIEKKYDICEYILLETQENQITEFVPRLILLQNDVIFFYSEKDELKDQIKIQKSTQIDILENNFLAFKITIETGTSFCIVTTSLSSKIQWICKILKLIDGEKYLEKMAKKYPNFYQIMKRVIALNQEKNKDSVYFKHLQHYRKDLIISSDELIWGFNFSTTLQQDLQGINQNITEIIDDEQQYYQDHSNTEDQSSFTDERKQGNSNIYDSELFGFEEVSNKGIDLFSETFSDNIEDLEKNQIENQIENQTENKTENKTENKTENKTENKTENQKINGFLSDEFSQEENENKIGNEIVFEKHKFFPSDGIDENQSENEIDEKSGFLSDEFSQEDENNKNKNQIQDKIEIHNNDLFSSNELKDELKDELKDELKNELKDELKDELKDELKDESEDEYVYEYEYVNENELKNELENKTKDEYINEDELKNELKNELKDESEDEYVYEYEYINENELKNESIDETKNKSEDEYVYEYEYINENELKNELENKTEDKYINENESKNKSEDEYVYEDENENENENDNDNDNDNDNDNDNDNDEYVYEDELKNKSEDEYVYEYEYENENENENENENENDNDNDNDNDYESQILEIVNLTKTDSQINYDSKSGIEIKIDSNNKKINSKEENQYTDESVIEEESDDESSFDIFSSPEEQESEKIYHSDNSVVILSEEVDEQKETDLQMNNFFEQTKDCNIFGGKMTEQQEQEESLDNFGKLFQKMEKQKEEEEFLRKNVFNRISKRDSEEDLLLMKSRSQENTRNELDEEIVEKLSQMSTLSQSQSVTFKTLHSTISSLDFSEEKVLKEENQTLSDELQEQKILIDSLQRTSENLQLRLNEKLPEPDLQIENEEEINLRKFFFLRNTNIRMMNELFIKDRVFEEISFEYKRLKKKIQEVKIPNWENIIENFDKKVDKIISEKEEKISNSKLQELSNKNNILHNKLSRTVDDQMKRFEAAEFLFSSKLSILKEQHKFSEQIAQHQLEIQNSKINQDELIINQLNQKINELELEFKEKVKNSDLLDSVSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN53</accession>
    <name>A0A9Q0LN53_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Suppression of tumorigenicity 5 st5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN53"/>
    <dbReference type="OrthoDB" id="206724at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF14">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="4"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1034" mass="121863" checksum="680498CA683BF119" modified="2023-09-13" version="1">MDNSNRVIDSLIITQINDSFPEVIYSYTIQESKFTRIKDPNSPFLISKIINEIVKLSFPDVFDTSSNKENAENQEKSFGSKFLLNQQFLSFLLDQEQHQIFAFFRRLNIKDKPSTICILSRKSWFQVFSEVTNILIEYIENENVVIEIINCINKQNLPKPGNTFSIKIINENLSIPEYKILRPEDDDALHFLTNFQALINSLEIKKILLVFFALLFEKKVVLVSSNIIKLSSSCHTLISILNPFFWQSLFIPFLPSCLFHKFQECDSAIVGIHSKFTLDIKKKFNFPFLLVDLDKNNLEHLNRFFNDKECFPLEDLKILSKNLEKILANQHKKEFFPEFACGNAFSDFFVQIFGNYLHFINKDEANSSIIDIHKFFDSLSESRKKFVSKLFQLRMIHKFFENHISKVLEYSDKVGTFERKFREKQFAEKFESENQEKSQNKKKWKRKLKIGRNRSQKKIEKIKSQEYQTNNDNQNKRFSVPIDDQQIKNSNQKSKSKSKSKSKSKQNKKLNQNSSGFSGALKKFRFKTWKNKKPSKDLPDILTSKQILEKSITKNNVNEKQEKKPKIIKRTRRPIPVPNQTLTRNSPIKKEFLNKRNLENLNDSIIDEMKLIVDLQNSSNPLFPKEYFIKINQNQENIKIQDDLINQEEKSLNDSITFSEDLENDSTNQSNQDLISSEIENENEIKNENQNENQNENENQIENENQIENQNENQIENENQNQNENEIKNKNENENENENQIENQNENENQNENENQIENENQIENENQNQNENEIKNKNENENENENENENQIENENQIENEIQNQNQNQIQNQNQNQNQNQNQNQNINQNEIENKNKDENHSHSHSYKHKHRHKHKHKHKHKNKNKNLNTYSPKIKKPDSNDGIHYSKNHHKKKKKTKEIDSNSKNQSKKLDLDLDLNLDLKSIPFSFDSNKTNESQKTSTQNSNNLNQNNKKSQLSDIDELLLLDLNTTSFNTIIEPSKELFINQNSNQNLQVIPESEDLLLDFNEQTIQTNFPFSKTENNSQSKLKNSFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN95</accession>
    <name>A0A9Q0LN95_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dual specificity protein phosphatase dsp8-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN95"/>
    <dbReference type="OMA" id="PRWHIIG"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14494">
        <property type="entry name" value="PTP_DSP_cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="118"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="24008" checksum="5BF5B99EF3BD6E64" modified="2023-09-13" version="1">MFKKPELISLSDLTNKKLKEEMIKTFRGPTKWSNWVIPDKLLASAYPGYLTEEKHNEILSSLYSKEISVYVNLMESFELKRFRSYRDGLEKIHKEKSADFKLEFLHFPIEDGSITDDDNIDKFTDNLIEKLNSDVKMLVHCWGGHGRTGTIVSLILGKMYSLSPEEVFSRIQIYHDFRLDPRGFLSPETQIQRDQVERILSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNY4</accession>
    <name>A0A9Q0LNY4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNY4"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="343" mass="40509" checksum="EEE8B6AF47D64BF6" modified="2023-09-13" version="1">MDSEKHHKHHKHHKHQKHHSHKKNSSSKKEKEEKQQSIEQNKTEEQNKIPNSPNPKKSTPPNSNISPPPKGKNSNPPNENKSKHSKRHESKETRKKPEEKTKKKSSSKKIEGKIMNLRFNEGTMKEIKTEGNKPWNAFVITDMHLNNIEESWFPISKIPATFKFLGEMIQKEKPDQIIILGDLFHSTCSDLNYCLDIMNEFLKFQLPTYIIGGNHDRRKVLRIKKRLTKEQKKFIKITKHYFMKITPHNNISVGNTNQNENQNENENENENENQNQNQNQNQNQNQNQNQNQNQNENQNINQNQNQNQNINQNQNQNQNQNSFKNQIKNQRVFQSTKFYSNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP09</accession>
    <name>A0A9Q0LP09_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP09"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="504" mass="60568" checksum="3175657847439B3A" modified="2023-09-13" version="1">MHLLDPWHVTRSIRRRYNKLVNKFCGSNKKKRSKEESEKMRKKKEHLMSWKESIIFHFLRCAKSCQGDMTTLLSEWFRYFLHAKGDHSLCPKNSPCTKNENSNENKHPEDKKITNKEEEAFFKMILSDFTIIKKLIFCRYFLSTSYNESFFSTLNGYREKIKNEKEINLGNQENEIEFNEKNVLQENQKKEKDMEWQKELLHLSLPGIFQKSTSYLKNLTLSRIKKKKRNSSEEIVPPQKEKKRSRKSPKRSKFKNKNLISTFLLSKIQPNLFDFENYSLLPTFQIHFKDALEMLNPKETHKQTQKETENSCPNIHDLHIFSNQNPSLLSRKSKIDNKNDVPIQTKTNNHNAIQNIQLPKPREIQLLEEDYIHNKREEIKRFLNDLIDNPINLYLPSGIQGSWWKRWDLEQMLESQDLSIGLVNFLYPQYQNDVEFTRLDFEPTIQKLHQEYKDFQAFKNRRNQIYEDFDKFLEASKKSYPKLIDHFNNFVENRPRMNKIDVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPA6</accession>
    <name>A0A9Q0LPA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPA6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF17">
        <property type="entry name" value="RETINITIS PIGMENTOSA 1-LIKE 1 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="230" mass="27548" checksum="73B1D49418256B69" modified="2023-09-13" version="1">MYSKPNLEIDVLLMLLFFFLFSFFLEQVVRLIEIEVEIEIEIEVEVEIEIEVEIEIEIEIEIEVEIELKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKLKTEIEIEIEVEIEIEVEVEIEVEIEIEVEVEVEVEIEIEIEIEIEVEVEIEVEIEIEIEIEIEIEIEVEIEIEIEIEVEIEIEIEIEVEIEVEVEVEIEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPT5</accession>
    <name>A0A9Q0LPT5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPT5"/>
    <dbReference type="OMA" id="QINEGWE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38019">
        <property type="entry name" value="KDA ANTIGEN P200, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38019:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="349" mass="42710" checksum="4617DC41062ABFEE" modified="2023-09-13" version="1">MQQKYLEQLQKEKERKLKEEEKQKKAKNLELQKKEEKAKKQKELIEKIREKEEQKKLETEKYLEDLEKKEEERRQKMEEMKRKKIEEEKKVSEQKLQAMIAARDRAKKQLLQKTRKFIERDQKVEERLKRLEEERRKEIEEKITSQKQKEEMRQNKLERASQIQEMKIRQLEEIQKQTEQIISEKKNEQQQELILKREKIKLKRKAKEENIERMKRKQQYRTSKQMEKIEKDTQKTQKLKMKREKIAQIRRDMNIQTMIEKKKVLENIEKIKQQGLSSLFKNETTLEDAIRSITSMSNSRIGTSFSQLNERNSVFSSISKRNQIENENENENENENQKENENEESNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ47</accession>
    <name>A0A9Q0LQ47_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endophilin-a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ47"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="106"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="370" mass="42670" checksum="F50172D1F2FE141C" modified="2023-09-13" version="1">MGLFKLFKKKKKTTKRRSNSNSISNSNSISNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSPIINQNNRRSFLHHQIYTFDSNRVSNHSINFYKAELSPLQANKKPFCEALFGFDAQNEDELSFQEGDKIELLSEDGDWCLGRLNGRSGIFPKNYVKILNEEKQELKMEAIKDYRGFNETEITFQKGDLIKIIEKSNQQWWKGEINGKKGLFPAHYVKEYVGERVKLPKVFVDKFENMGFEESIIQKAYENLGYPKIQDEDQIFNELLDKIVEMIDEKEKSIKEENDEQEKSNREESDEQEKYIEDEDEDEDEQKKSNPNPNPKSKSKSKSKSKFKSKSKSKSNSKSKFKSKSKSKSKFKSKSKKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR30</accession>
    <name>A0A9Q0LR30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR30"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="167" mass="19124" checksum="D16FC0EEF15976D6" modified="2023-09-13" version="1">MEKFSQNVWNLKIDFIFHCFNLFGWFFEIGGLASFEETIQKTLVLYFLTTMFSLCVSIAMIVLSGFEKLGTKARNFFIFCIIPIIIFNLYGAQYIYDIFCLAYKENSLSCLTESRIFVVGATFSTFGLAGLLVINTIKSQDLQNKGYELISGENDPKKSKLENKMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRJ5</accession>
    <name>A0A9Q0LRJ5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRJ5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="41034" checksum="EAB94CE21EF0B9B3" modified="2023-09-13" version="1">MSETISALEDKKWELFLISFLFLILFGWFIFEVIQNIQFLKLRIQKTRKMAQLRSAIFIVGSVFSILRFILFFFKLNLKDKFGLFTLLLSNITFNYENKKNRFRKIIQISIITVLSITFISQIILCSVVKTYSDQKFSWIGIVYGIFALFIPLICLKFLFVINQFKKKQTNLTLKIWSIFILIGTYSSIFFIRAIWDIFVLAKKNKLNQKFTDWQENDKNSYYLAFFFWYFLFEVIPCLIIGITLHLNPKKEIQIINQKLFNAEMLVLLSPQPNNLFSNGLDEDEFENLDNNNNNYSHNRNFSSNVEKNSLLTRLTSETQMDIVKDNFDLQWKKTQEMEFSEKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRK7</accession>
    <name>A0A9Q0LRK7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_05806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRK7"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="542"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="961"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="820"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="725"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1074" mass="125715" checksum="B7E66E1D3CBA0D79" modified="2023-09-13" version="1">MCKICLEREKDSLLLPCRHYALCYQYSQKICQLIQKNDLEELKKIDQEIFQKMKMKRNQTILQFVIWRKKKELIPFFLSVGIDINNKDTGQNTALHIAIKMTPDIEIIEKIVSLGADVNSVDSTKRTPLHIAVANGADIKIIEFLIKNGANLEIKDQKYNTPFLLALNNPSTNLELLKILLSDLNQFQKTHIFNDYPIHIACTSAKKLDVLDWVFENSISLINTNGRFGKTPLQLLCSRNDSDELIKFVMTKYKPDPLFPSSNSSIALHYYCESSPKCEILELLIPNQSCVNHQNKNLETPLHNLCSRPAEINIPVLKFLHQKGANPNIQNKFGLTPLFFAAQRNSIPFLKVLLEIGADLNILENHNKTALHYILSTSYWFPSEIVRFLIESGTRIDTVAGNGDTLLTSFSKNANKDNLDLFKLIASKFPEQLNSDQKNNTVFENLCMSKATVEFFQIVKKPKYLDLNKANTRIGLSPFQTILRFNQNYDVIKYFMDEFRIDINHIEGSSTTPLHTAAEFCNEEIVSILIQYGANLDSFDYYKMTPLHVSCGRNMWSKPEKVIEVLIKSGADINMKNSYNKTPLEYFIQKNSSGFWDSNQYNIIQLFIDYGTDIRDFFDKNPLPTSTNIIEILIKNGANINYINNGKSLLDNIYYSKKKAVFECLVSFNAQFANPNFYSNNNLRKILAHQYLQKDFENLLIRQEYTNYRFSTTGDPIYVDKMFLLFRLKENEKEKQIENENQNQNQNQNQNQNQNQIQIENQNQIENQIEIKIKIKLKIKSKIKIKIKIKIKIKIKIKIKIKIKIKLKIKIKIENENENQNQNENQNQNQNQNQNQNQNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQIENQIQNQLLLNKIYNYLSKETHQNAMKILKFIYTGIIEFEKYQENWDLISKFTNEIGFDKKWISRKIGRENFIGDLKRLKEDEESKDFTIVVENEELKIHKVILFARSELFRGMFLSVNDDSKKVSDYSGKTPNAFKQIIHFFYLDDFDLENFNEEIFTELYDVENFYQMNLSGLFNLKLNQLKNKFKRERKQKKQENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSX1</accession>
    <name>A0A9Q0LSX1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="863"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="972"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="5">
        <location>
            <begin position="1423"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="678"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1269"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1269"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1283"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1339"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1551" mass="177346" checksum="6A9A1C3E3310A762" modified="2023-09-13" version="1">MQTKFLSQIKKHLSTNGEQTFFSDVVTKTFEKGNQEASCLLLLTLYKVYLIPRIPKNRWLNIYIAPEKRRKRFEPLIKEAEDTEFDNINSEQGFLESYYAHCNRMEIKSNTQIVEYSRYIFRKAQKTNKLNLTKMLWNNSSEDERNQLDAGPLFGIVERNITFQEINVSKFPGKGTLGYLADVLKKNKEIRKIIAQSVKDDEGMQRLWKAISHHNCANLQSLDLSKVNLNDKNTTQLIVEALSQKNIGICKLKLNKCGFNTKSLTWIFTEMKKAEKFNKIIKRIEINGNKLARTGSKAFIEWLECVTSKTFSRLSISETEAEINGILSVLLSKFTESLTHLDISKNNIPQNSAQIKDNEEKEDLLVLLVRRAKLLRNLDISKTNLQLDVFEEVATALGNESESSQLYLACNANSLGEKGADTITRLLVQKKRLSGLEFMENEIGDEGISTIVSTQKRYHDSMKTLKIGRNILPRAQVVPSSGIIKSLLLQSSCGLKFLDLSGNSKFFHRNYLNEIFPALAKNETVISLNIQGNQMGDIGASLMCQCLRENETLKNLKWDDNRITLSAVRQFAETLDANQTLVIAPFPERDIEHVTTKKMLVEVSLLRNNIRAKLQLNRQRKWDEQEKSKMRGKGPKRLDFSNLQILSPRQSPSPHFERTPRIDDQYFSIGNTFENKMEKKDEFFLPEDEKKSSPFDQLDQTSNSGNKEQEEVTIMQKYSLGRHRSLSSPSLPKRVQRRSRSYVENTQLNRNVDKTPKTLSKADTPMEKFEAQVSLQQGAKGYRCMEEATELVDMTEDFRTALLSGNMHEIKNCMKQGKGNINMVWRSEESTAIHYACDVGDADILAMLLLEGGYKYTEMEDVSGLTPLQRLVVKALSVDCLILLLDFGADIDAQDNREWTPLQNCVHNYSPEDEDDTHKRVQFLELLLKKQANAEVRDSKGWTAFHRAASMGFIDAVMLLGETADINSVDNYGSTALHKSARNGHTLCARYLIEKNARTDLLDKNKQTPLDLALIYGQDDCVSLLELYDTQHFPSLFSRIAQTQPVNDPQSPRLVVEMPQFAEEDLIKSVPLSRIFRVCVFGNAKCGKTALVERLVSDQFRDTAPTVLESHHRKLLVVNQQEMLLHILDVSGDDAYLPMYQKWISSADGFMLCFSSREDPSVLYDIENKFLLRITKFATHLKQIPIVIVSLQNDPSSDTLSQKSTNSLAVSLAEKLAIPFIQTSAKQNSNIREAFITLLQSMYNILGREEMIKKENEKLRLERELKQQEMANRREQREKQKQARQVADPLPLTSQTPLLSTTNTNTNTNTNTNTNINESQNTNINESQNTNINESQNKNTKDTLNKNTKDTPKIAIPDMSNFKEIDLVNLSPVSPRTDEMLAKRRMEFFSFKVKNKPKKGKNKTKTKNKSKLIDSIDDLPKLPFSEILINPKFCFWFQNYLKQEFADENLSFFFAVHQWKAINPNNDALISLSAKKIYDEFISPKAEFQVNIDGITRTKIKKKIQDCDFSPVLFDDALEAVLHLMRTAIYPGFVRSPLYIHLWEDDSTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTV2</accession>
    <name>A0A9Q0LTV2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_04911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTV2"/>
    <dbReference type="OMA" id="WPGKLFG"/>
    <dbReference type="OrthoDB" id="773693at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5078586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="569" mass="66519" checksum="DF01006EF5B9A2A7" modified="2023-09-13" version="1">MISKIKQQSLYLILLQGASRAISFLFNLWIYDILYAQKQDVASFALINFRFPLIRDALLDFSRSGYRRAFARTDTQNKATLPTIFTIVPLSAIPFGIIFSILTYLLELSGSGTDLENYSLLLGLLCFTTWLELVSEPFYIVMQSLVHFDVRMKVEGLAAITRSISLYLIIRFFNMPLFAFSISQFLCSFITFLGYGFYYISDKRVTSKEKPNDLKGFRIFFKIIPNFRKLFHLDQNAKEMLKLVGSFTLQNVFVFVLTTIGDIILLTFRNFEIEAIYGLANNIGSLGLRIVYFPIEETIYTLISLKVASLEKEKEKQNLKENQKEKEKENQKRKSKRKSKIKKKIKKKIKIKIKTKLLMLKFKKFIKIFLVFRLVFLIAFFYSVFGSNYTFLFTKFMIDNKPKSEISLIIGFYFIYTFFVIMNGINEIFVRSVSSKSQLFKNNILLVVFSGLYIAFIYTFAPRYGSMGFILANILNKSVSGIYFAYFTYKYFTSFKVSFNQFFLDSRVTLACFFIAIILFSSSYFFWIGVYGLFIHFIIGIFCFLLLCGFVYKFEKRTWKELLSKKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUF6</accession>
    <name>A0A9Q0LUF6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inactive tRNA-specific adenosine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUF6"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058535">
        <property type="entry name" value="MafB19-deam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="134"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="264" mass="30716" checksum="EB57A2013CD34553" modified="2023-09-13" version="1">MSNPSFILIRHENYERSIGKIFLFATEIEQKKTSQILNQLSNFPLSKNFDHLKRVKRQTSIGKNHVILGDKEMIKEMENIIKENNLRVFEVAVPQYKPHTKDQLKEALELWPTTWKRSPKSVSETPYLTQKEEKMAKYFMQIAIKNASIANQYSELPIGGLIVDPKNGEILAKFSKSSRYLCTDLDLYITREPCVMCSMALLHSRIHRVFFAKKNKDFGGLCSIFKIHTNKQLNHHFPVYQLIDSDLLNELNEIEKNSTLKNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVF9</accession>
    <name>A0A9Q0LVF9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVF9"/>
    <dbReference type="OMA" id="MQAVSVK"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="59"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="441" mass="50074" checksum="7E42D27AC997A6A6" modified="2023-09-13" version="1">MIVLTQKIKESLLKSPALIQPIKQLGFRLFSSPFKDVEKAPEDPTFSVKDLFHKSGHPRKINLSIGAVVDEHEKPIVLQVVREVERDISGRKDISKSYLSIDGSLAFYKEAEQLILKTDNEAIKEGKVCTVQTLSGTSALRVTAEFIHSEFPDKSIYMSEQIWTNCVHIFEHSGVPIKYFRYLKDPITLDFPAMCEDLEKVEEGSFVLLQTPSHNPTGLNLSNEQWVHLADLFIKKKLIPVFDCKLLGVVSGDLDLDAFAPRHFVEKGINSFIIQSFSENMTLYAERIGALSVIASTKTEAQNIRTHLKAIIRAMYSNPPSHEMAERTQKMRELLYKDLIKSKTPGDWEPLKVQKGLFSYLSLKKEQIKELREKYGLFLSDDGRICMSAINNSNVNYIVYALGCVITGEKNHNGMNEEELMKKPDVNKEDEDEDDENSNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVP6</accession>
    <name>A0A9Q0LVP6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Importin subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVP6"/>
    <dbReference type="OMA" id="QQYQERW"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="845" mass="96736" checksum="C341B821020E03B3" modified="2023-09-13" version="1">MQEEFTQILLNAQNINLQIRQEAEQKIQNARDSNPVLLTEMLVKELNDEEKPIKSRHLAGIVLKNMLISKNKRQREILANEWISYDENHRTNIKTLLYKSFNSESHIIRNTAAMVLSEIALIEIPKNCWGTSGISDMLNNIEKTTNPDLKETLLTFLSYIFEDIPFENIESQISDSLRIICQELENQNESIKKSAIKAFIHLISLSEKKLTNIDDINFIINLILQGIQDQNIEIASLFYESLIKFATVFYQYLSDSIQKIFNILISSITNPDSQLCIKAIEFWTSICEKELEIQTKLSTNSESKLVYHNFISQVASHLIPYLFENLQNEYELDENEWDPSKASVVCISSITSVIGDSVISIVSSLIETNLTSSSQKQQESAIICFGSILENTSTTKMKPVIEQGIPIFLELFNKSNQQISKWTSWTISRICQFHPESIINQINAMIETFFNGLTMGAEIAINICWCFHYLALGLGDPEKETGILSNYFQNIIENLFLASDRDDSDETNLRVVSYESIIMNVLKAPQDCLIVISKLVPLMIEKLDIINKLEVLSDSERMKQSQIQSNICGILQSSTLRLGVEISNISKQLLESLFNVLEIEESFAHQEAIMAIHSIMNQIGEFFSPNIPRFVEFLIRGLKSIYQQNLSQISVEVIGELFRDFPDYISSRSDEIINLILEILNFPEFEISTKICYFTCLADISISIQVKFEPYLDLVMEFAKRICELDFNQKNVEEIVNFYLLSKAAFEVFTGIIYGFSRVNQQSRIEKYIKQMASLIEKISTIPFEFQDVEILQSSCGLIGDIIQCFGNDMKTVFNPLLIKELIKMSLNTNDQNLIETAKWVSSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWE2</accession>
    <name>A0A9Q0LWE2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWE2"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="136" mass="16467" checksum="BBE6E2F84077949F" modified="2023-09-13" version="1">MKKLKKQLKRIYLNEKENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDNSKLSNKSFQILEYWIYSNQIKDGIKITQQMIDEIKIGIDYFQLNQTNPNLFDLLIKKFKNQNQNSKKKDCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWW2</accession>
    <name>A0A9Q0LWW2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000006">
        <property type="protein sequence ID" value="KAJ5080598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWW2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="182" mass="21709" checksum="88CED9FAC9303A8A" modified="2023-09-13" version="1">MALDLCFDFIFILDLDLLFILRPSQLLSSILIFFSHLTFLPFPFFHVCLLSSSSFLLARLLIWCLISAIFSKIEYENLPCNIQTAENGMQDDPQRHDHKGFHILYQANSFTPVDHTLLQYIFYRIRTSFIQVNRINKRQIISRFEKDINELKFMIVISSCKVEITIWRRNCRLEDWNSFEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX98</accession>
    <name>A0A9Q0LX98_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dactylin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX98"/>
    <dbReference type="OrthoDB" id="6487394at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="445" mass="53063" checksum="BE14A4DAF9B160DE" modified="2023-09-13" version="1">MFYTRHTTRNQFTFSQIEQLITKKSKMDYSNKKIIPNQGSESGDPFQDLPDELMLEIFSYLEKPFELGICCPVNNQFARISNDYMLWKEIFRKYSGLFDYNTIRLVDSTYFEIMEPLGIEEYFNQNSEQNQSLQLQIEQQPKKLFNEQIKKFLNLKKQQKKRQKAKERQKKLHKTKLFLTSPGYVTTIFCLILISVMFACSKFESYFNKSYIFIVLPALISLAFLLILTGWFVVFPSTSIVEKIYSITCFALFFDFFASLLLLGLTADHYSDLQNHSWIFFVCFALLFSHFVLWIFLVIYNKHEIKIVAYNQNLFHQIHEFWGFFSFPFFLSIVFLLVAFQKAKVAMIFLICSNIIPWILFCIFRSQDTFLFRDLRKLEIPHLVISLLAFATELMMYFRLFRNVSINWILISLPITIPLFFFCILLCFCIYKECLNHMRSAFYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXJ3</accession>
    <name>A0A9Q0LXJ3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000007">
        <property type="protein sequence ID" value="KAJ5080590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXJ3"/>
    <dbReference type="OrthoDB" id="6418750at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="129" mass="15301" checksum="9364B7335D2B44D1" modified="2023-09-13" version="1">MASEIGFDQDWVAYKSKVESLIDDLKKLYEDKNSKDFAIVFQDEKIQVHKFVLAFRSNLFRGMFLSVTEDKSNQVSDYFSSGLLALQSLIQFLYLEKIDQELDQSQFTEIVQYYQMNLKYLDEINSFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYB4</accession>
    <name>A0A9Q0LYB4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000014">
        <property type="protein sequence ID" value="KAJ5080085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYB4"/>
    <dbReference type="OrthoDB" id="6418787at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="149" mass="17842" checksum="A3599D495ECE908D" modified="2023-09-13" version="1">METYLNLEKLSNDLKNLFQNQNENQNQNENQNESYFDFEIICEQKEISFKTHKSILSSRSEYFKSLFKSKMKEYQENKLILKDVSSSILFSILNYFYSGKIEINSENAIQILIFSSKYLIDELIEIVQNLSKRIYNLKLLLMFLNYLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZJ5</accession>
    <name>A0A9Q0LZJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein mis12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_13838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000003">
        <property type="protein sequence ID" value="KAJ5080730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZJ5"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="101"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5080730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="272" mass="32220" checksum="AF8AF8B4365D182B" modified="2023-09-13" version="1">MENQILNLQTQFFGFFPVDFFDDVDNAINDYFADGIDAIEKCLLAEMKVKYHQEIKDGCSRTFEIFRPIIQKYFDKFEIYVQRNIFHFPPQILEKMLINEKQIQDQQLKQESHKIKSLEESNSKLRDKIQNLKKEIEKMKNQKIELQSKKKLIENQFKTKIVSKNNIQNNQEKLSQFIQKVTSLNNDSESSSLHEMINFSVQFQNYIQNTNQEINQLISSEDLLLLNKQKENDPQFSKSLNELQTQFKKDFGSTQIKSLKEVSNLNQKISNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4Q7</accession>
    <name>A0A9Q0R4Q7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="147" mass="17727" checksum="6D3D35BDDFBB3919" modified="2023-09-13" version="1">MIYSNKIINPKLYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIKITQEIINELETGIDYFQLNQTNPNLFDLLIKKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5I0</accession>
    <name>A0A9Q0R5I0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Activating molecule in becn1-regulated autophagy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5068019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PAH"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="70"/>
            <end position="192"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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            <begin position="17"/>
            <end position="29"/>
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    </feature>
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            <end position="312"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="679" mass="81194" checksum="E06B80FB9428D67A" modified="2023-09-13" version="1">MKRSIKNDSKNQKKENNNTNNNEKNFNNKNNKKKEEKEEKENSNQSNKEEEQKKINSDFNLFSQQNSKLFSQNENENENENENQNQNQNQNLNQNQNQNPNLNPNLNPNLNPNLNPNLNQNLNPNQNLNPNLNQNLNPNQNLNPNLNPNLNPNLNPNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNINQNLNQNLNQNQNQNQNQNENENENQNQNPNQNQNQNQNQNQNQNQNQNQNQNQNINQNQNQNLNQNQNQNQNENENQNQNQNQNQNQNQNQNQNQNQNQNQNQNLNQNQNQNQNNFGQNSHLYPRFVQINQINQFPNLQQNPQLFPQFFPNFIPLSEYYNFQNGNFQQPQIHPFPHNLYQFQTNDSKNTQKNQTQKIQEHAFKTLNSHQKLNHTNHVSNPSILGNKDPNESIFGVKQFLLNVQKRFQKMPNRYKTFLKIFNEYAQSNKEEIRISVENFLSDQSDLLDQFRKLFNQDPNGILANISLWKACQFLGNVKKRFSSNPKVYFDFVKILKDQQEKKLSHELVRTQINELFKNSPDLLDSFADFTQDTGILQEKQINFTNQFPNQFPNQISNQNQNQIPNQFLNQFLNQNQIRNQYLNQNQIRNQYLNQNQIRNQYLNQNQIRNQYLNQNQYLNQNQIRNQIRNQIRNRFKNRIRNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R693</accession>
    <name>A0A9Q0R693_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S100-fused_Epidermal_Struct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22571:SF51">
        <property type="entry name" value="FILAGGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22571">
        <property type="entry name" value="FILAGGRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
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            <begin position="575"/>
            <end position="617"/>
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    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
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            <begin position="622"/>
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    </feature>
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    </feature>
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        </location>
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    </feature>
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            <begin position="1071"/>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1783"/>
            <end position="1797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5068036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1823" mass="215427" checksum="D904C7FE2F06C443" modified="2023-09-13" version="1">MDLSSLQTKKTFKAKSDIETNESNSKLSLLQSKPKEKENKENKENKENKENKEKQEKNKNIQNIKQFSTHPQIEEILNEKKNLINNLNQLTNNFGQNNLTWPIKHQSNDELNQDPDLFNSTKFSENNFSFSNNQIVNYPKNSLQKSKSLSNYSIVRRELFDDDFQFKNNAFAKNNELNKNLENKGKNSNFFGGSNQFIYGFKRFPSENNLSTSIDKTINDSRTGFENLQSHSDLNYKKTENQQKNLSSQTLNLNKKENLSSQTLNLNKKENLSSQTLNLNKKENLSSQTLNLNKKENLSSQTLNLNKKENLLSNGNSNQFDNLDIFTQQNFQKNGKTTLKQMSNIVSQISTQMKNRFDEIEKSYRKETETQESTSKNLQLKEFQIKNDEEKIIRDNQTLRKLKKRTKIDNVFVENLGSFLWNCGNTFPDLIKILQTQEKDYEEHQKLVKIVNSRIKNQNTRRKDSVSNNSKNQKKNQFGKKPKSKQIHREKKKNNNKGKSEVKYPNDRNLDFLRSHKRVPILDSNSKKDGYDEYEYEYEYEDDDEDDEDEDEDEYEYGNENEDEYEEKITPNLIRCRCGKNDYRKGMIKCTICNFYQHQECIDVITSNDLYCCEKCEPRIINCPCGNNTRDPKAKLIKCTRCLGFQHLSCIKSYDPNLILCTYCQLLLKQKKMKMENRIVNLNQNQNQNQNEIEENQKIITQEPQQQIPIKKSYNFKLICKIDKPKKIRSFENRKRKKKSKNPSNLKHIRKSHQKNKEKFQFMKPKELDNLLSINDFLFCPKENKKKPLIGAVSNDLIIDSILNPKENQNQKEIKKENQKEIKKENQKEIENKNQNKNQKEKENNEILDKLQKKTIETIKKEDQNNQRIKTDLIPKEKEKEINNKEKEKEIKKEINKEKEKEINKENYKKNEKAKENQNQKRNQKRNQKRNQNQKNKNQKNLSRSKNEEQNNLKKDNKNEDKKEVNKNINNKVDKEEKKKANKNINNKKDQELKNQKNQLKKTDEKDNSTKKEIEKKAVIIIKENRKSTLRKPKNSKIQENKQIKDIKKDKQIKDIKKDKQIQKKKDIKDKKSKYKNKKNKNKKKQSSESESEDEMETDSDSENESEDESDNEIETDSENESEDESDNEMETDSESENESEDESENEMETEDESDDESDDETENESDDDSEIETDSEIENDSDEMETESENDSDDDDDSNNNQNETDSGNDSDESDDDNQSESVSESDSDDDDESEYQSENEYQNEIKKDEIKKDEIKKDEIKKDEIKKDEIKKDEIKKDEIKNDEIKNENENNNHKKEKSKSKSKSNKTEKSNEYQKTNKKSKLSLSDYKKFRNTKKNEESKQEKQEKQEEQKNENKTNDKKSPINIDPQSSQTEKISPLKIQQQYSPQDSTYTDILQLGRSSSDTKLVKYPPLNYHIINEKQQISKFFPSNLSSRIPIIPKNDDQNIIQKNTKIYDPTMNLDTDSNTKIINANSNLETNSYSSQYPLNLENEKKYTNEKDDNLVESTEKNRISTKKYDNSRMPKAQIQPQIEHYHHENETDPKNTELDFTQLSSFPITRSQSYETNIHREIHSNTPSQTMTNTSQFFPVQNPQYFFNKNQSTPFFSNLSTLKNQNFQEKKPIQDYETYHLNNLKEEELAKKSPEVIQFENQTAKNDEKSNAVKNSQLNGPMKITQKNINSEERGGYFLKPYSIEQESKEDDNFGRKNHEKKQNIKINLNLNSNSHSQRYKFRRNKNYHYSRKPSHNQPFNFRQKNRYVPRFFPNQESQDAQDMEIEEKQLRSFSPSLVYKNNSPNDLEYSNIEDINLKRGKKPKEVDKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6Z3</accession>
    <name>A0A9Q0R6Z3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_12093</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007869">
        <property type="entry name" value="Homing_endonuc_PI-Sce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05204">
        <property type="entry name" value="Hom_end"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="12">
        <location>
            <begin position="966"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5068921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1337" mass="152822" checksum="78F26565FAE8DC13" modified="2023-09-13" version="1">MTNVLENAKLSIPRISDGEKESEFGVIFSVSGPVVVAEKMTGAAMYELVRVGNSELIGEIIRLEEDTATIQVYEETSGLTVGDPVLRTGKPLSVELGPGLLSNIYDGIQRPLKNISEITDSIFIPRGINAPALDKEKKYYFTPSGYKVGDHITGGDVFGIVQENSLITHKIMLPPKAMGVITWITEAGDYTIEERKKGYPMVHFRCIICSKTVISQSLSKWSNSDVIVYVGCFRKGTEVRMFDGKSKKVENIQIGDLVLSHDGKSREVINLVQGKETMYKINTQENYSNKKPFNLEFTCNASHVLHLITPQEIQKTTFSFNNNNYTSVSFFQLKFDNSPYKKVIHRTKTWNHSDYGENKCEELAQKLVDKLEQGPKEFIWQIEIKYWETLSQKVQQSSSQLLSPILIQNKEFRKLCKKHNINNVSDAAYLVGLIFENSIQNGLKSFKTKNPQIKHKFQQIAKSLNLEHQITHSKKSGYSITFENEGNYVHPFLKMIEKLALLNKKKSLSDLFSCEEYNIRKEMISGLIDSIQTKQKENEPFIELKTSNHFTKSIINELSRSLGIRVSTNAKNSLIYLETNSMLRSILSKSVSLNQTHSSPKKVSLEYQRYNFTVEKLSRENYYGVTVQGADHLFLLQNCFIVHNCGERGNEMAEVLMEFPQLTIEIDGKLESIMKRTTLVANTSNMPVAAREASIYTGITLSEYFRDQGYNVSMMADSTSRWAEALREISGRLAEMPADMGYPAYLSARLASFYERAGKVKALGNPSRDGSISIVGAVSPPGGDFCFSKGTELIMHDGKLKKVEDILEGDLLMGDDFSPRLVKDLIKGKSSHFKIKSIYNDSVFDDLVVTGNHVLVIHFSPVLHLIKSQNSFEVNFHLLNQYNIMVPKSISFENEKEAINFINSFPKALECEVTVNQFLQWDKKAQKQSKLFRSEKPCHFKSNNSLQMKMEEFGIENINIKDISWLFGLFVSIGKNEVNGLKFRINKEDEEMKTKLISICNKLDLNVEEEKQDEYDVLSLENSNLTSFIKSIQISNDVLTSDYENIRLPFLSGIIDSIAEINQQNNYTLDLPKQSMDSIKFIQYLIRSCGLLIKSKDSKHFEIYGENINKLPLINERKKVFRNGNLNGKKQENYQFDFEIEKLEIGDFYGFRVDKNKRFLHKDFIVTHNSDPVTSATLGIVQVFWGLDKKLAQRKHFPAINWLISYSKYMKALDNFYDKTDPEFTNLRTKAKEILSSEEELNEIVQLVGKDSLDESEKVILETAKILKDDFLQQNSYTEYDRYCPFWKTIWMLRNIITWHNLAMKAVKRSTREKRITLAKIQAAMGPVIERISSQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R751</accession>
    <name>A0A9Q0R751_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ring finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R751"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="822" mass="98256" checksum="779ED30839FF706E" modified="2023-09-13" version="1">MECINTIKKSYKEHYLKFISENLFEKYDIFARKYIEDQNSKKNIKTKFKKIFLQQPQLNSEKESISNEIFSIYQNLIDDTLKTDKLAIQKMKDKYQNNLNDEMKIIIYSTVFKLVEEHYSENKINLANESLDYSAFMIFETAHKYLKNKNIVSPMFNQKQIGKICNIFGLGNYNEPNILFRLFDIDTIIITRISRIIHYSLLYLVGFYSHKNKDKLIIRNDNDKKIQEKIKNQITDSDENFRKLIYNEMESLSNILNISMIDTKLYYSLFLSYISKPENINSNLNEIEKWKELLKTTFKEKHEDILLQIKQNKQNNNSIEDSILLLNKDPISNLTSKFLKPKEIDEYKKKYQIISFFLENYSKLKILNLFPSFLKFSSIIHSKYSGKHKFETIKFKTIKDVLKEINQNYENIEKWKNEFIECWIYSLSEINQETAINFNRKIKYIDEKNEKNKEIEYLTELIKIEEINETTSISKFLPYPENQINIETIIRFVCKLQHDLKQQIKTILFKEKEKEKEKEKEKEKENIKKKKINILFPFKVDLPNKETNVVDSDFNFGFKEINEHLKFHNINNFDDFENLIKQKLIPSVLTYDIFINVENFQFKDKVIVDTSFFGKIEWEQVEVPTNIFNELLDNLKANSQLSFFSFICEDLINLCSDLDSEQKQPDIEQSLSQFIDSNNYIPQQEISNIFKNNQELKSIMEDLKIKHLHSIYENIQKNLTNIIEQIDPKYKKEPQANHLDNFREFIKEIGLTKLLMIFQTFFQKLVSSPQIFKEDDLLKDCLEKEAKSKGFNELAKSIKENIQEDIEIKFSVKIYEFCLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R756</accession>
    <name>A0A9Q0R756_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R756"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="388"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="480" mass="55294" checksum="F5B5F3BE0DF06B42" modified="2023-09-13" version="1">MNEIIFFGYNEYPILFENELDEIKKPIQFKFKFENENENENENEKQIKQISSGDFSTIFLFKNGKAIEYLKENDSNQNPQKIQIEENIQKVSVGFKNEAILTSEGNVFAKGKDINPNKFINISSLIEDTNDRIIEDIVSGFSSIYLLTSNQNVYGIGSNVSNQLGLDSQTLKKTQKPILIMKNVSKIFSGFSTSVFLLNLNQELFGCGLNRYGRLGLGESRKEEIKIQKLAKIQNIPKGKIIDIQSGYSHSIMLIENENQNQNPKRKLYSCGYSEYNGLGKYENAYEFTEIESSLFENDNILDFSVGRQHTLILTSNSKLIGFGSNYFGQLGIGDTKSQSTPIQIELPKLRFNEDISNYHVSCGFNNSFLYYSPFLSSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQKNQNQNEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R781</accession>
    <name>A0A9Q0R781_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate 5-kinase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R781"/>
    <dbReference type="OrthoDB" id="423343at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SARAH" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="130"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="266"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1001" mass="117226" checksum="CC54A6041E3200AA" modified="2023-09-13" version="1">MTNLSLEEELKRIEEEFRREMEKINQEYEQDRSLEQNELEEKYKDGVKPIQFTSKIDSKKEIDSKKEIEIKKEIELKKEIEFKKEIELKKEIELKKEIDSKKEIELKKEIELKKQPRKEILLDIPNEINDLNTLLKFDIAIIHFEQFLIEKFTPNDLHFVIAVQKYKAISKIQERENYAKLMLEKYFNKQTKFPIHCKEETIEKMFNKLDKEELDENIFNEVDEEVRKYLKDEPFDQFCESKQMKLLIKDWPKIQKKEAVSGPETQRKAIFTSFYSEENEYISKLNKFTKDTVVIISNLIGDDLKKETFVRIFSNFENICIEAIKWKVNLDDIKASWSLKTKLGDFLASKLNEMNSLYIEYISNFQGCIGFINFVVSSLKPECVYLKKKIGKKKLTNLGTTLKLPVIQFKEYQKFIRDIAQSTWEFYDDYVQIQNLLEISDSLQEQINTIQKIPVKLDSASFQVFQQLKFSRMEQGEVSESSQDMIKGEVVYIFSFEDCIVLAFENKDVFDINTIDRSLVMQQGYKPEVCFNYLVPKEAVWIHDSSEDDETTSHMLEMITPEKSLVVFLNQKSQLKQDLHNFLMKLFGETRTSYLGFDKRFLKFHHSNQATYIGNFVNGKLEGKGKIIYPNQSVFEGQFEAGKKQGSGKLTFPSGDILSTTYSYDKANGPFTYAYQNGDFYYGLFRLDSSDGYGEIFYASGGYYKGDFVKNQFNGKGEQVDANGNRYIGFFKDGLRYGIGTFELFDGSIYIGSWKNGEKEGFGEQFFCNGDYFCGDWANNLPNGNGQFQTKNSNYIGGWKFGLRNGKGKMLYSDHQTYEGEWENDLRSGSGTFINKNIKYYGEWKNNLPNGKGNLTISNKDITNNEIQDRKNLHTKYIGNFKDGKPHDENMHEDIVNRYSFDGSIKFGEKNGKGKMNLKNEVHFSGNWKNGKFEINEENFRTHFLKKPTQDITSIYEDENTKSDEEMMIHLSNEVNPISLINENPDFWLIPPDENFIYEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7U2</accession>
    <name>A0A9Q0R7U2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7U2"/>
    <dbReference type="OMA" id="TEMGQQE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="151" mass="18378" checksum="A67E9F519A874A91" modified="2023-09-13" version="1">MKKLIRKFKKKSNPKKVEKKEEIVIEKESNQTEPEAQEILEIFFNHFQKQIELEKKEKEQENQNETNDENVVTLEDDENDKEDDKQNDKENDKENDKENDKENDKENDKENDKENDKENDKENDKENDKENDKENDKENDKEKMIKKMMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R820</accession>
    <name>A0A9Q0R820_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nnp-1 protein putative nuclear protein 1 nop52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2184" mass="255743" checksum="2C3AC6C51C3AAEA7" modified="2023-09-13" version="1">MNTNFEKETEIVFNWVSRILARNVFPQMSLRALAKYWCQVINKIVPGSITKIYLKEAENIQNLQNINKACLEFGIEKKYLLTPNQIQKENRLEYFVPLMKQIGIKANLMNFQPKFDFVFNQEAQKVEETDKNINDEKNNPRQLKKMNTKLKSELMEDSVKIEFEFKIVSIEEENDAFLILLNPPKRATIYLTERLKPLISWKKNLIHLIQPVVKKAFFQDPTIQIGLFHLNRKCLQFFEATTALEDLLEIQELTEYLYSLVSQEKNKQPKPQKIHNDNDKKLRNIAFIMKKIINKENILLKFSDCIKNRQGTIFTAKYFQNDSIVHDCVLDTRAQKVELFSQGKTLLSEKMGDINISKINKDSLMIRSIPKKQKFTIIPYSKIMKQIMYKSISLMAKAKHPKIISPFLNRKKRTISKNQITMNSNLNQFIEMKENQSKQKIIKDPNILNQIESKPIEIEITIFFESEYFSGLLTFSLMDFSLKIAGIGKQNEPYENITYQIHKSNPLLFRLEILNKGSYICCTESPSKREFLMNIFYQISKQTTENQENIENQENIENHENNENIENIENNENTENTEGIDFESLSKSSSQKISNLQQGNFQFDDFLVSKEEIKSNDWVNFSSPNSPNLEIIQKKQDKKSQPPKELILYPEWNEDIVGNFIQGLASFDILLKNLKTNADVQGIIIFSRSKITIQISGSGKYEIDYTIPGEKQILPLEIEQESIGLLRIVMKPNFWITFKPKNEKDLYLIPKTYEMFQWYRSASLEATPINGFILGFESEFEAILTSLLHRSHTVFQIQFFHNKNTYNGILRLDSFHTTIMTHQNRAIFQLKYDPNRLHIFDRPDSDRLLELTTKTETIPVIFQTEIQKLLVFRYLTHMLLDTHIERDSKKPKEISKSRTNQIAKTDLINPIFQNKTFNDLLLFSQFNDLGSPQIIQSIETLTALDVPRLLMHPIFQIKIDDSVAKIRQQVEKFLQIGKWKFKVKILGKNKNKYKSKITVKFGTLKIVIDSGNSNDKDKFAFPFDSTQKIWIDPKEQNRFLLKLSVQETLLVESKTAQSRDLFVNLFFAAWNRNMSQKNKQSTLENTTDSDNEDKQRNKFNLTQIMITSCKSATSHYKNDPNKATIFGYPQVTSKIPCILPLNTDINNVVSHLQTTYRVSVFDSFWRFISSGEIQLNAQHFVIKFGSNSISRYYSPFSRLLRPNMSEDPLLIRFMIDEESFIVIGFSSLEIVSGFCLDFDIRKKRSSPFNKWSQEQTTSQTVFNCSFRIGESAQHSGQLCLENGQFSFKLNPFSEMLKLTKSEQEADFHDQNKLLRNILRAASFQYSRITKAKISKTDPLMLQVFLGFNLFVTVFFPSVEQRFKFYLDFNNKRRRFLSLEKLHLVYHSIAKDCVKKFENVSVFMEKKDFPIGKCTVIISEENIQIAKGSKQYFNHPINLCRQVESQTNRFRTKIKAQLFQKENQEKQKIKKIPKNQKKQKTILLDFESEEAKKLFSRSMEISNLTTFLPSIIKKFEILKKGKQFNIVHFSEEGIPICEGAILVDEFTIEISYKMVNQEQEPIVISTSSVKFMIQKESPVTGRLEIKNTVFLMQFETAKKRNHFILEFRRFKERMQLKEKMLLEGKYDPQLDPNSRSPLEIELDYEIQFEKQWKKDPISLPSAFTVSVMDPETHELEYLNAELRILGDLVEIYQKREEKPTIRFRVARGFTFEELETARGLWKLSSQENTVLIRFFDLQTKSKTIQNFLTLKKILKRKIYNVMFKQLSVMYGSIIVDGSIEFEPTHIVLHIHPSANEEIIKIEAHSMKINFKPKFMNFEIITATSKNASIKVMPQNLEQRNEILRRLLDLRLGWLEKNSGLVKRKMSSVFQLEDDPKSAAFSVMIFPDRAKDKPQTATLSLFKKNFMLMIFEGEEQEIGYSSDTRIDFYREDPAVIRLQMAIWFIYFVKFKNIQDKTHFVSLLTRLLESYKNEQNFSYLPEPPPRSQLKLEPIFEHSQDMQTLPVIVNLSSHVDKGFKIKSQIRFSSKGISCENGIYDTYFLLVDPSFQVSRSSKSNSFKISNSSLDLIVLFPSLDSTFLFRSFIKESFKNRFKAVIVKTNSINFRSLEPVKIKFNRENFSLLFSSKKIQIEYPIKEEFVKIRISDLDDSFAKLNFLENSKFFILKFINKFSSEKFYNLFPEKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8C3</accession>
    <name>A0A9Q0R8C3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8C3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="369" mass="43684" checksum="F20C1585773926D3" modified="2023-09-13" version="1">MNFSFKNDLDLICERIDAKIIECFQIYGEMNSFIGENMKVLKDGFLVLSQAQLSMRTSDRHRLTVIKNSKLEALARIYVENHEEEDLFFLQAKNEKENDKENEKENENDKENDKENDKENEKENEKENEKENDKENDKENEIDNKENEKENDKENNKENEIDNKQNEIDNKENDKQNDKQNEIDNKQNDISENIPNQTIIQSEIRYRKRGGKIDSKIDSKIDSKIDSKIDSKIDSKIDSKIDSKKDSKINEKNDEKNDEKNKLNSHLFGGKNDPIRFFGLFAPQNLKVAQFKFWDSLELITKIAQKKKKILKLIPEIEKLIQKKEEILKQQLNQNENQNENQNQNQNLNQNENENENENQNENQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8V3</accession>
    <name>A0A9Q0R8V3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mtl1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8V3"/>
    <dbReference type="OMA" id="MQNILAY"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47819">
        <property type="entry name" value="DENTIN SIALOPHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47819:SF1">
        <property type="entry name" value="DENTIN SIALOPHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="431" mass="49973" checksum="86899D3036034A6A" modified="2023-09-13" version="1">MDQSKCNKKLKEILKKENIRKISLDFIIQKLIQSGIEPNIANSSETMNFFLKILTEKTKSNEKNKKEEKQKKKQLENNESKKSKNEKEKEKEKESENENENENEKESESEKESEKESENESENENEKESENESENENESESESENESESENENENQNQNQNQNQNQNQNENQNQNENENEKENENVKRRRIKRNSKATETKVERLRNFLKTAGFSSKLRGIGKMTSLKKQFNFLMDIIEDLKIDTSQINQRYAKIIKKQKEKEDEMKQLGDTKVLTRRLRSKKRIQKRSKDSKDSKDSKDSNDSNDSKDKKDSNNSNNSNNSNDSKDSNDSNDKKDLKDSNDSKDKKDLNNSNNSNNSKDSNDSNDSKDKNDSNNSNNSNNSNDSKDSNDSNDKKDLKDSNDSKDKKDLNNSNNSNNSKDSNDSNDSNDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8Z2</accession>
    <name>A0A9Q0R8Z2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8Z2"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="151"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="68636" checksum="C0ADAAA432F8CD49" modified="2023-09-13" version="1">MNDCLFFGDNQLPKLIKNEPNSIIKPIQFKFKNENENENEIENEIKQIAICYFSTIFLFKNGKAIEYLNGNDPNQNPYKIQIENIQKVTVDSINEAILTKERNVFAKGKDINPNNIKEFINISSLIEDKNDRVIEDIVSGEHSFYLLTSNQNVYGIGSNQYGQLGFDSETLEKTEKPILMMKNVSKIFSGDSSTHVFLLNSNQGLFGCGENEYGQLGLGKSKEDKKIQKLTKIQNIPKGKIIDIQCGNYHSIMLIENEDENQNPKRKLYSIGNWFYNGLGKDGYTYEFTEIKSSLFENDYIREFSVGNGDTLILTSNSKLIVFGSNSHGQLGTGDTKHQLIPIQIELPKLRFNEDISNYHVLCRNNKSFLYWSSPFLSSFSNLEEDLINLFRRKEFCDISFKTEDGEIISAHKLILQAIIGQDDQIEKLQELISNKSSKESNQIFEMIYSNNSKINPKLYEEIKIDFNLFVSIEESMKELIEFENEKDFIIERKEKQYKFPKLILVMRSKLFREKFLSVTESDSNKVTDYSELSDESFQILEYWIYSNQIKEEIQITKEIINEIQIGIGYFQLNQTNPNLLDLLIKKFKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R960</accession>
    <name>A0A9Q0R960_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R960"/>
    <dbReference type="OMA" id="AANEHRI"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="134"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="564" mass="64893" checksum="22BF8E26D75657FE" modified="2023-09-13" version="1">MQNHQEKELEKEKEKELELKPIPNKETEKEKKKEKKQKNKSKEAEESVLYLILPPVLLFATLLISSYVGNEYEEEFGLYPYFDVRDLSINIRKELYFSEDRKTTFLDEWGSAYGYNNTIDDFASSEKEHLKGDVYLDYTGSAIYTKTLVDEITSDWKINFYSNVHSRSTSSVRTEEQIQTIRRLVLEWFNTSDEEYSVIFTSGATASLKLVGESFPWKKESQFVYCRSNHNSVIGIREFATQFGAGFTVVTEPDLVEKDPEIIAQYPSFCEKSQMQYLTEPPDDLYHLFAYPAESNFDGSKFNLSMIDRFHHDHLFCNDTGKWLVLLDAAAFVPTNRLDLSRYKPDFVALSFYKMFGLPTGIGALLVHNSVAPLMQKLFFGGGTVMISSCESHLCVLHPNPSTRFEDGTVNFLSIIALKYGINMLNSLGIQSISDHVWTLTRYLYTNLISLSHSNGQPFVEIYGKHHLNNPLYQGSIIAFNLKNPDGTYVGYFTIQKDSADAGFHLRTEDIHQLVSEKRSCGDKRDFIHSKPFGVVRVSLGYLTTFEEVDYFLTFLKMKYLDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9C5</accession>
    <name>A0A9Q0R9C5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fch and double sh3 domains protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9C5"/>
    <dbReference type="OMA" id="NSHAAKY"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="354"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="415"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5071967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="470" mass="54092" checksum="37F62777D8F43035" modified="2023-09-13" version="1">MSNETNTTDPLGKPIKNLLASSVMNKTVLQFVTERTKIENSHAAKYKKVPTSGNSEKAKLTKQIQNVLDTFLNQEDVAAGHIANFAAILDEQTKETSKFSKDFEQQIGKIIMRYNKIKSELEKQQADLTKACDKYLQKSEEAEKIQYDLEQKTAGKGTKKEINKLQNKHRGLQSQVNSADKDYQVIFENFSVTQKSFKEHVDKLSDQITKLMRERISRFQETINKICDLRDEYCTLITKKTIIINETINAINHEEEIKSVILEKGEQKNYPTCPELELYDFKKLNEEKERFEKQVEKVVDVKEEKSPQIEKVIQEKKEEKIEPQQITQPQQTQQITQPKQVEQETQQNYQQQQANTVMARALYDFHDTDPNCLAFYAGEEIEILDQSDPGWWTGRLNGKTGLAPASYLQIIVTQPNEEWGYIAISFAARDTDELTVEAGEKIRILQKLDGWNQVMNSRGQTGLIPSTILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9J2</accession>
    <name>A0A9Q0R9J2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gtp-binding protein yptm2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9J2"/>
    <dbReference type="OMA" id="HDQVTIR"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="370" mass="42909" checksum="B6BF8CA3C5D17816" modified="2023-09-13" version="1">MEIQKDYDYKINILLVGDYRVGKSSLSLRYFEDKFQDSYISTIGVDFKLKTIEMNEKIFKFLVWDYQPAERFWEMPSNYYRGAHGIMILYDTTNQQSFDNIKKWIKQIQNYAKNDVNIILIGTKIDLVSQKVIDTETGKKLAEQLGYSFFETSSKENINVNEAFETFFKQTGTRVVQTNSNQNSNTISNSISISNQKDKKEFGNYGVGKTSLLTRYTDGNFTNSYNSTIGFDFWDPTGAERFLTITRSYYRGTSGVILFYDVTDQQSFNDLKDWIKEIQDKADDNVNIMLIGTKSDLVSQKVIDTETGKNFAEQLGYSFFETSSKENINVDEAFESLTNQIYQRVKQIPQEKSNQIKKEKDDEKKGCLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9L9</accession>
    <name>A0A9Q0R9L9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9L9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="118" mass="14027" checksum="DA062F948D212A37" modified="2023-09-13" version="1">MSKRGVQVDWDSPNEDDRYDYRTPPKIETYDKDQWTEIFDKTPFQILHEYCVGNNFAPPQAKNPRKVNFGFAVEIYMPHLKRSFIAKERPNKVSAKHETALMILNEMNIDLEYWGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9W1</accession>
    <name>A0A9Q0R9W1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9W1"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="87" mass="10517" checksum="749A7E36573BC997" modified="2023-09-13" version="1">MRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEDEIQITQEIINEIQIGIDYFQLNQTYPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA14</accession>
    <name>A0A9Q0RA14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fucosyltransferase cazy family gt37-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA14"/>
    <dbReference type="OMA" id="WSCANSI"/>
    <dbReference type="OrthoDB" id="428346at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009969">
        <property type="term" value="P:xyloglucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004938">
        <property type="entry name" value="XG_FTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31889">
        <property type="entry name" value="FUCOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31889:SF2">
        <property type="entry name" value="FUCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03254">
        <property type="entry name" value="XG_FTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="461" mass="54309" checksum="0C118EB3CC67EB90" modified="2023-09-13" version="1">MISQNSLSFNQKLFTFNTMMLISIFFMCIISQFTYSVSQNKKEKSTLEDIEKNAKNQNRNIKENQNINIKENQNTNIKENQNINIKENQNINIKENQNINIKELNENWFENYLDFYNKTLDEITTFSKKNAKFVVFRAVDGLGNRLMGLVASFLFSILTDRIFIIDWPYQDGHITQVYDLMKQPLFNWDFDSVANFYDEKEIYQTAAYFDFADHEDMSLFLCEDFQTKLDKYQFIFMRTNNYFSPAMMNNKFFIKKLESKFTQKQIHSMFSTLGNKIIIPIDSIQAKVDDFVEKNHFHSPGKYPIGIHLRNLYIHSSLNNSWIWSCANSILENKIQENPEMQNLEPIWFISTDNIKDKKEAKANYPDRFLSRDIILDRNSIEGNQESFVDMLLLSHCNDILTLYARSSFTYVSHGLADINPYVKKCNHLPSSEPCFHGFRQLSKTQCFESTIINNLRTECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAG7</accession>
    <name>A0A9Q0RAG7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Repetitive proline-rich cell wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAG7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.900">
        <property type="entry name" value="transmembrane domain of human cd4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021963">
        <property type="entry name" value="Tcell_CD4_Cterm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34008">
        <property type="entry name" value="REPETITIVE PROLINE-RICH CELL WALL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34008:SF2">
        <property type="entry name" value="REPETITIVE PROLINE-RICH CELL WALL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12104">
        <property type="entry name" value="Tcell_CD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040212713" evidence="3">
        <location>
            <begin position="17"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="T cell CD4 receptor C-terminal region" evidence="4">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="222" mass="25722" checksum="82CCD997A8FB46C6" modified="2023-09-13" version="1">MFSLFCFFLIIHFVLSQNCYGVSGCETCVQNGCAWCDSNKGCWPSEADFNACSKWMTSKDECGPKLSTILGAVFGTFGGLILIGLIMFCCVRCSQKNKKRESQRIAKSNQKVSDEKSVEIKPFIDTPLLNDQQPTFEPIYQQPNYQQPNYQQPNYQQPNYQQPNYQQPTFEPIYQQPNYQQPNYQQPNYQQPNYQQPIYQQPNYQQPNYQGPIGMNFEQGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAL2</accession>
    <name>A0A9Q0RAL2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U6 snRNA-associated sm-like protein lsm5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAL2"/>
    <dbReference type="OMA" id="YETTPQG"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="111" mass="12574" checksum="39DE1B1526A40610" modified="2023-09-13" version="1">MDFVLPFEIVDKCLGSRIWIKAQKQREVVGTLCGFDADLNMVLSDVIEYQYKIDGSIEKTHLDEILLNGGQITFLVPFKNGPDEVLNKQINQSNISNDVNLEIEKEKSNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAM2</accession>
    <name>A0A9Q0RAM2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAM2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="271"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="324"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="496"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="603" mass="70425" checksum="1F136582490D76D7" modified="2023-09-13" version="1">MNDCLFFGRNKYSKLIKNKPEIITKPIQFKFENENENENENENEKQIKQISSRELSTIFLFENGKAIEYLNKNDSNQKPEKIQIENIQKVTVGKFVVAILTIEGNVFAKGEYINTNNPEEFINISSLIEDTNDRIIEDIVSGNRSIYLLTSNQNAYGIGSNDYGQLGLDSETLKQTEKPILMMKNVSKIFSGINSLAVFLLNSNQELFGCGDNEHGKLGLRESIRKEKKITKLTKIQNIPKGKIIDIKCGIDHSIMLIENENQNQNQNPKRKLYSCGYYQYNGLGKYEDTYEFTEIKSSLFENDDNILEISCGFEHTLILTSNSKLIVFGNNNYSQLGTGNTENDQSIPIQIELPKLRFNENISNYHLSCGSYKSFLYYSSFSFSNLEEDLINLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQDENQIEKLQEIISKKSIQESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVKDYSELSNKSFQIFEYWIYSNQIKNDIQITQEIIEELETGIDYFQLNQTNPNLFDLLINKFQKQKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAN6</accession>
    <name>A0A9Q0RAN6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinase kinase 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_08953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAN6"/>
    <dbReference type="OMA" id="LEHAYDI"/>
    <dbReference type="OrthoDB" id="2672723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="86"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="559" mass="64361" checksum="944F48972060C05F" modified="2023-09-13" version="1">MLPNNLQSRICQICFEKFSTERKPMIICSYGHNVCSYCASFLEECPFCRSPKSKKPTINLLVLEMIEEIEKREKIKIPEINSKELFIENSPFSFGAVADLYKANWGNQFVAVKKLRMNPSKTDKKILKNEVEIASNLPHPNIIRVFGITKINKQLGIVMEYLEPGSLEKIIPTLSFIECVNICLGIIDGLKYLHSKNVIHRDLKPANLLLDGKVPKISDFGQSIIHQKIFQNANIKGSIEYTAPEILKNETVSDRTVDIYSFSMIIFHLFSKKKPFDDLNLFQIITYLQKGIRPEISQNLIPESLSRLIIRGWSGNPTERPSLDEFRKVFQELKLFFENENSNSNENLNQNENLNQNENLNQNEKFDELSIQLQQFLQISPLKSNQNQKNKNQINFSKLEVEQCIELLSKSENEQKIQEKGIERLSNLSIIRENRTKISNLNGFQVTFSIMKKFPDNLNIQLNGSTILANLMTKNKENQSIFANLSGVQIIIGLMNKYPDNESVQQKACLILKKAAENAENRFEMINWGFSFFIAELIHKFPNNKEIKMIGQSLINQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB84</accession>
    <name>A0A9Q0RB84_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB84"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF3">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="473" mass="54844" checksum="59D028B5E008BDC6" modified="2023-09-13" version="1">MIQKYQIETKKTKMKIKKAEITNQKKYQQKRDLEEEFSRIKNLNIDPDNIQFMKKQMENLMGVLTQYQKTHNTLLSLSRLTKENDSTENQIRELNTKKLLFEENINYFTSGAKKIQRELQTVLEETNRYQVEISKFQQNIAEIEKNEKELNQRFAQLSNEIENMKDLKKTTPKIDSLSVSWNQTKKIKDVHKHFISSLCLNHSGNIIATGDHDGRINLWDSQLAKLHKSIKFGKSYGIRSFDFTKNDNYLLSTTDQGSVSIVEMNQLKHIFYKSITNKSISDAKFIDDGTIFISGGMENNLILYNIENQKTTTLETSSPCISIAVRNQREFLSSHVDGKIKVWNLNTRKVIDEFPEQDSQILSISLSPDNLQLLITTQSSFKIFDVYNTTQPLAEFKPPSAEISPTRKNAVFSPCQNYVISSCQNTLFIWDILAKKNKTNLKTDKPAKFVAWDRENKNIVASIENSIKIWKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB90</accession>
    <name>A0A9Q0RB90_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB90"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040133919" description="Fibronectin type-III domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="417"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="855" mass="96458" checksum="B123A122C5E40449" modified="2023-09-13" version="1">MKSILFFSFFFFLIINIFLIQSNQNQNQKSIPSSLLTETTRYYSTPDEAWIWNLLSNYTGPGDYFGRSVSIYKDVLVIGAYDVNQAFIYRYNGTNFELEQTLDGPSVSAFGRSVSVYENVTVIGALAENQAFIYRYNGTYWNEEQILNESASYFGSPVSIHKDVIAIGASSVNQTFIYRYNGTFWNQEQILSESALYFGSSISIYENVTVIGVYDENQTFIYRYNGSFWNQEQILSEPSALYFGYSVSIYENVTAIGAPNAFEAFIYRYNGTFWNEEQILNESSVSSFGDSVSIYGDNFTAIGAHGADQVFVYEVSLIPQVNIVNCSSSFLSFDCYWDKIEFPSNLEYQINYGYDWIDIDSPILEDENVYYQQFNSSIYDNITGNEYYSIQIKACDNESMICGESSSLINLTTKIDSVKDFQLSNPSNNSINVTWNYPNVQINEGIAHLDHYNLSYLIQSQPDLISFISVDNSSLDYLLNNLECENDYNISICGCRTQECEGDDKGEIVESLFPLIFGEVTNFSCSIQYSLDINCNWNQPINCSIPFYYNLTYQSISQNDSGNYQPTSTNQQFTVQLPNQEYQINVSACNSNGKCGYISSISITTDNLTISPTIYETISKTEEIEFNFTKLTNANNYSISLNNGTNWEKFTSLNLSGNEVIGIISGISGNIEYNISIRGCVDLNCETPYLGEPSSIISTRAKLGDITSLICYAIINGFICSWDPLILSSGLKAYSFRYNLISICLPDLRTYYSVPGLQGGEYYEISVYSSANETCYYDPNSGIESIISVTTLSQTKETNDNSKGTIIILAVLLPVVVIAALIFFIILIKKQKNSIKRIIKKREKELEKSGGIEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBE6</accession>
    <name>A0A9Q0RBE6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase ubr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UBR4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="MWHRAKK"/>
    <dbReference type="OrthoDB" id="30336at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025704">
        <property type="entry name" value="E3_Ub_ligase_UBR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045189">
        <property type="entry name" value="UBR4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13764">
        <property type="entry name" value="E3_UbLigase_R4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52043">
        <property type="entry name" value="UBR4_E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin ligase UBR4 C-terminal" evidence="4">
        <location>
            <begin position="1401"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin ligase UBR4 C-terminal" evidence="4">
        <location>
            <begin position="1579"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="region of interest" description="UBR4 E3 catalytic module" evidence="1">
        <location>
            <begin position="1915"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2293"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1684"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2311"/>
            <end position="2323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2429" mass="281537" checksum="A57210DF9F4F1FEE" modified="2023-09-13" version="1">MTYQIRKLINFLFNESEKIRYSTTKALINELISQKKAKTKTLDLFEIIKVIIENLQEHFKKGERENNHTEFLPALRVLFYLIITAPISLWKKQVSEKNENLNENINENINENINENINENSNENINENSNENINENINENINENINENINENINENTNENINENINENSNENSNENSNEKQIPLPQFIIQNLFQIIQSQQIILDNSKPNNNIELHLLIFRFIYKILQIKELGKIFGTYLYSENWIEKIHNILSLIDSLLESENFDFQSYEKKETNSGLLSIKRTRKVNLIPFFDKEFATKYNINHIIDNYHFPMIETCLRIISCIQHIYTEKEKEKKEFNFGMEKWQKTLCGLLENEQTKQIHNLIHNILFRMVKGDRSKMHFILDEFGIKKELMQINEQEQKSNKFEKEISYEKYENIVSNLVNLRNIAKNRPYNWIRYCVANKGTFEKIYWLMFALPVNKHETVCLDLLTLSIGEYGEEKKQIGKVVDSSFFFRNEKQVLRQLVIEGLIEKEDSKVRKQIAEMIPHLFGLLDKSQVVEVRRFVWNQLPNAAKYGKQSEQYMELVENLEKELNDNEEATERSYFMQILANTLGKQNRKLNKHTNSHIYQFLQKNIKFEGFYFEEEPCLICNTIDTQSTNLDLKKLAKEIKYTDSAIYIKLKNTMLIESVFFDCSEISKTKQVKKIDFYYNNKNVTRIIDLKNKWRLWKKVQPLKLEAYQQHAVVEFAVPIIATNFLIEFSDFYQQSFGLFEKQTCPRCGAQVRDRAGICSQCGENAFQCRQCRNINYENLNAFLCNECGFCRHCKFVFVIKAKPTISSEPLEKDEDVHAALQTLDSLSETSLQLFRENEKHKATILELMSKMQFGMAPRNEDRESIVNPDMHLIGKTYGLHSKQISAKIVENAQKMLATGREITSYIEKAEQGEFQNGLEKEEEKNENFDNLDFNSKKAKKNVCYGCAENFAAMLVHLLSNAIQRVKTGDLGDREEKNLLDELVSTSMRRGTAEQRTMARQAIVEMARRSPRAQETLAAGLRKRFELALSHAKSSESQTLLGEDVGLLEEISTSKNGKKPAKIWIRFALHLLEKIAGESQYNTPVLSEMLVLPCLRILEKNKSVKMTWKEFNARRYMNKWIALTNKKQQEKSQGLIVKKIGDPVSAFLQIKLVKKMIFNRWSHLVRLETAKILRQISTISTQLLDRTTTVLVCVLSSAHKAGDCSREFFSLFRRIAARKEAKYRLVSQGFLSLVTKLIMEEISRISMLEKSRIMSKVSEGLVLTALIDLLEDFLDDPQIIDQFKQEKHMESVLQGFLTLRGLVLQKSKLTNLSARKLSLIFEKLRTKDEKNQALFIEACVRVLDKHRTGRVPLFIMEQIAEIACPVPQKPVYKLKLVKTPTQEEFVRGSMTHNPYSTDEIGILMRDVKNKICTELELFGLIDDDNGMELLVNGKIIRLHLPITSVFEQVWLPSIQKDDADIDISRSESINSVNSIDEPSIINSLSGEMTRFENLLQTQVQDIRAINTQFEMKSKKSQQKDIPPMAVVYRLQGLDGEATEPVVDSLQDSTDDFQEDFSNLDFLYDNTSENLDLSKNVIYEYQKRHKILTVFGNSGGISALLKIIQNISLSRIDKELVSSALRLLVHASRVKSNRQIMIQSRAQDVVLGGMVKAFRQNVEAEMLQMFLIVVEKIVTEINAQVKNSDQLKENLNENENQLKENQLKENLNENLNENQNQNENQLKENLNENQNQNQNQNQIEENQIKENQIQIQNQLKENQIQIQNQIEENQIKENQIQDQIQMFLDMLILPAVSRNKHLAHDIARILPFLTLNKSKAMEFLIKKFLPCMDFQTIDAAQHPDFQCTIMIECLKDLSHAIRNDESGKKLKNTAVEVGIIQFGTDYILRIFPPNLASDSKEWKAGTTSRCAPYILGILAGLARNHELTQQKIFESGIIESLIALEKLSTQTNLGTLSENVLDICSQNNKKIADHVNTLRKSIKEKQRKKAMEKRAEMLRQMGFQELNSQRKVAMPQVISKLDATEFGEIVEEKGLKCSICQEGKTLEPEKPLGFYIYSKRMPLEPRNIIGFDALGISSVTQFNLIHFSCHHKAAQVDSRGEHPKREWDGAYLRNSQVLCNNLFPILLDNLPEQQYLTAVETYWSRLEAVFGSSIPFSARSNFLLHDLKFLLLRFARQESFSIDAHGGSPETNILVLPFMLQMANFLLHLNDDQNQKDLEPKISRFLEIQKDEWIMKSIRTIDNVLFYSTASLLMWPLDQWNSHRLKILEQMILYSYVCFAESKHTHSHKPKRSNLKKQSTDTEPDEKQKSADSSIDTKENDEKLDLDFSSLFQTFKPILNFFALLNKIHFQFKSPSGSLVQTLNTTMSDPLAVLDTSKVILKYFQEEILVIEDILEFLDVLGLLQDVLKQYESVEKWIEWILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCV1</accession>
    <name>A0A9Q0RCV1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCV1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="321" mass="37390" checksum="0E23D1E58BB92C1B" modified="2023-09-13" version="1">MVSSLEIVKRTARAASGTGSPQLYIIGIISAIVALLVLYEIIRTIRLTRSIWKNITSRFRILILSSCFLELFLTSIFFLISFNWKSIFSIIFFYITFPVWLQFCTFTFYILYLAKTLYMIEGKETKLKKYLDLIFGILIGFNFIFVILLDYFNSKILEKGKSNLGADILATLYIVFLMVPLVVLFTIMGVKYFKKSKEYVLVKIQKERIKYTIILIIIDDLIFTVFLVSTLFGAFGANKITSTVNGYLEDEEYSKYDTSILLITLIFVMIPAFVLFLILHRVLSIEKRMFQREENILLTDSFDYYSNVDPINSFNFDLKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDP8</accession>
    <name>A0A9Q0RDP8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A-type inclusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDP8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="943" mass="109611" checksum="28DA90C0A66A9F92" modified="2023-09-13" version="1">MNNFLFCLDNSFNKSQENQDSIQKQKLFLAQFFAFMNKKNIPIQVALFNLESENPVLLQEFTKEEKEIENSFEKLSLIEKKIDIGNYLNEVIDYLESSNSDSPTEIMVLVFHRCFFASKLNVKEDLLSKISICVIDFTVELDNFMIFNELKKILPHFKSFRISFNENNLIDDSKLEEVFILSEKKHEKKQEPQKKTNIDHDSYIRTYTQSSLFSPFKKLKSKENPLIKSSQIQKRVQQEIAKQQEYDFDELISDPKKTQIKINLQNLTSLLKEVDSHIQEIKTQSDEIVNRYTELSLSFIESNITKALEDTNQATQTDANSKESIEIQLSIVLSFLDESEMNEFMSNQEKNAETPNPEIDPTQNKEKAQEQPKEVRKGMNDLVQDNPKNQEGNQSKYVFNQDSDSDPDNGFQHPVMRIPSNHFMDSDSDSDSDSDSDPDNGFQHPVMRIPSSHFMDSDSDSDLDSDSDSNPDYTNFMKKYSDKKDHSNPHFDDPRMGMGMGMRMGMDRDMIMGMRMGMGMGMDRDMGMGMGMGMDRHLPRMGMGMGMGMGMGMGMGMGMGMGNFEKDPLSDIKDFEKQVEGEFKRQEDFWKEVQKKVPSDPIFCSDEKNTITIQNNIQLLYHYLDEISSKLQENIKKKEIQANKLKEQEDHLKKRQEEIQPKKKEDKDENENKKEDKDENGKEDENKDENEDKDKDEDKDENGKEDENKDKDKDKDKDKNKDKDEDEDKDEDENKDKDKNEDENKDEDKDKDKDKDEDKDKDKDKDKDKDKDENENKAKIYLNFDINETRKKLEKGKKKEKILIQIHDIYDSLKTKVETRISEWIDWNSKLDSGKPLTEEQLIKRQKEKKEEEEKKMFSMKDTSLITMNDLAMSEDYEDEDDDDDIIYDSDDDDDEDYNDDDSGDDNSGDDNSGDDNDGDDNSGDDNDGDDNDGDDNSDDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF26</accession>
    <name>A0A9Q0RF26_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF26"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="294" mass="36101" checksum="A259E675F7B7D75F" modified="2023-09-13" version="1">MENEMNLEIKEFKKYSKNIDKFLQNILKKFNWNEKELKNDLEKQNEQENKENLQKEMNPIFFYERENHFPIFPQNKLKEILKELILQSTNLQELSLENILNSNTNNQESNSRFMRIQQNFQIHQKIINEMKLNNFPDNFFTDFEINRLFQFLSEIKNGFEIESIFSSILGKENSQKFALNIWKILLIERIENEPKYFNYIFNSFQNKTIFYQKLTEESKELFIKNLSKKSIQKNTFEINNPKEFRNFKKRNLPNQNRKIRSKRKYKGKNRSKTMTEKFREIIEFEMEKLEEKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGS5</accession>
    <name>A0A9Q0RGS5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neurobeachin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000041">
        <property type="protein sequence ID" value="KAJ5079063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGS5"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="82" mass="9572" checksum="469168995A234499" modified="2023-09-13" version="1">MGFGNYQKSSSTQKWVNGKISNFEYLMILNSMAGRTYNDLTQYPVFPWVIADYENETINLKDSKIYRDLSKPMGSTWRESSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH51</accession>
    <name>A0A9Q0RH51_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04459</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH51"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="390"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="602"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="701" mass="81038" checksum="A13507029BAAD75F" modified="2023-09-13" version="1">MSSCENENPSLQIIKLLISKKININFKTKKNETALHISCENTNTSLSFEIIKYLIKKGIDINSKTNYNETALHYACKNKNASFEIIKLLISKKIDINTSTYQNQTALHYACQNENPSIEIIKYLIEKGIDVNLTSYYNETALHIACLNKNISIEIIKLLISKKIDINIKTTQNETPLHIACKNVHSSIEIIKFLISKRIDINSKTKAGNQTALHYACENEDPKIEIIKYLIEKGIDINSKTNQNKTALHIACLNRNTSSKIIKYLIEKGIDINSKTKQNENALHFSCENKNPSIKIIKYLIEKGIDINSKTKDKETALHFVSKHQNPNISIKIIKYLIENEIDINSKTKYNQTALHFASLHFACENQNISIEIIKYLIENGIDINSKTKYNQTALHFACKNRNPNISFEIIKYLIENGIDINSKTKYKNETALHFACENENISIEIIKYLIENGIDINSKTNENKTALHIACENQNPSSKIIKYLIENGIDINSKTKYNATALSILISRRKEKLIELLLMNDANIFDLKKRQITNQFIESFLKIYSINEDMNNLLNSNDNFSDLIIQSKDEIGFDSKWINSKKGRKGIIKDLSKLYQQNETKDFTIIISKEKEIKVHKLILIIRSELFKGMFQLNVQDKSNQVHDYSQKSFETINQLIYFLYHDEFEKEINFKIIEEFSDLKDYYQLNQNSIIDLILKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHA2</accession>
    <name>A0A9Q0RHA2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_14381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000025">
        <property type="protein sequence ID" value="KAJ5079603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHA2"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="462" mass="56228" checksum="870CBF2B6DE229AE" modified="2023-09-13" version="1">MGLRSQSNADPDQEKQLFEFYKLIWNLLRNGKLEEANELCENNGLFIFQASFLKKYNEFRSFKNQNQNQKNQKNQKNSLLDLTRKLWLKSCYYYSRFPQNKYQSALYSLFTQNFQSAFQVCNDWQDCIWVHFVTKLFSIINQQLNHFFELIQKNKKENHQESLFERFEISGLKILDSKLNQKQEQIFSAKFQNFEPKNTYQKIQHMIIKGDLDQLYHKISKWIADPDYYFEPNFWFSIPKEIEDQNLIPFQQRKPEYQPLFRISGFQKSAHQYEDFLITCFDPKNKLQKEKIPFFEKPFEELKIAILQNNFQKAYQIYHFMQQNKQHLNDSNEEIGIWQMLIEAMLEFGQLVSFLQEIIKKDPNQKEMEKLEEKSNYTLSFFYKIFQFEDFWISPEMNEERFDLKQKIFPLSIILIQILYLFLNKSEDSFQLVNLVCDEKYELYVYFDSISLDYFLKNLAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHT1</accession>
    <name>A0A9Q0RHT1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_14007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000008">
        <property type="protein sequence ID" value="KAJ5080562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHT1"/>
    <dbReference type="OMA" id="ELMEWLN"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5080562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="659" mass="77691" checksum="8F4274A21EEF2DF6" modified="2023-09-13" version="1">MQIENNQEKKQKQFATEIIPKIHSQNLNFCWGIGNELFLFGGSTSAFYCPKKQRKEINSQENNIYILSWDTTNNESISKFLSQTHSIFVKLQMKQNQLSNTDTLEASQGYRIALQNLKQNLIKQLDESNEDFQLNLDLANSVNPKAFKDEIESEAKLVDIMERVFHLCENFFLLHSKYPSFSFVRWFQLNFTDQLEIESIDTESIKWNKICRSIIHGKFENAINLLAKFPPNQTIQNTQKILQEFPELKYQTHLTIYRKQFQNWRKKCDKIYNSNEEIKQNPNLSAIYKILLGDENEINQRTDSWIERFASKLLFIYPNLEIQSFGSKAKECFTEKEKKERINDLDQIYLDILSLNTSRALLRIYSQIGNTWLSAHLSDLLFHIDSIQKDVLPTLGTDIREFFVLEFCQTLLSNPSRMPILVDYLISCQKMGKMLLSEIVQRQNIDDEFIYKKLLNICQNNQLDLEYKTICQIYGMKSFSSHKFPSGINALLEAEKIEIVNSGINRFFKKIVSEEIPLYQIQLVIESLESDKQNQTSKKVLFLKHYKELCEYFQENQMDKAGRLILEIMKKEIAPKMFWLTLIWDAIVIMEEEEKKIEQEQFQKNSIFNHDSIMFFLTKVKEITSSHQANEYTQYISKDQLQVIRFNLIRALPIRIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHZ0</accession>
    <name>A0A9Q0RHZ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="425"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="495"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="567"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="673"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="710"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="744"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="812"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="849"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="885"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="921"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1205"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1094"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1316" mass="152407" checksum="3F583E90A38A3989" modified="2023-09-13" version="1">MNKNNTELIKENELILHFAIEKQVSKEIIEELISKGANPKLTDKLGRNLLHISIINNSSLEIIKYLVENGIDINSKTIYNETVLHYVCRYNPSLEIIKYLISKGIDINSKTNNNQTVLHYAFMYNSSLEIIEYLISKGIDINSKTKDNETALHYVCLNKNPNSLEIIKYLVENGIDINSKTNNNQTVLHYVCRYNPSLEIIKYLISKGIDINSKTIYNQTVLHYACRYNSSLEIIEYLISKGIDINSKTKDNETALHYVCLNKNPNSLEIIKYLISKGININSKTKDNETSLHLICKYNSSLEIIQYLISKGIDINSKTNNNETVLHYAFMYNSSLEIIQYLISKGIDINSKTIYNQTALHYAFMYNPSLEIIEYLISKGININSKTNSNETSLHYACLNKNPNSLEIIEYLISKGIDINSKTIYNETSLHYACLNKNPNSFEIIKYLISKGIDINSKTDDNETVLHYFCKYNPSLEIIQYLIEKGIDINSKTDDNETALHYACQNENPNLSFEIIKYLISKGIDINSKTNENRIALHLACQNPNSSLEIIQYLILKGIDINSKTIYNVNALHYACLNKNPNLSFEIIKYLISKGIDINSKTNDNITVLHYACKYSSLEIIEYLISKGIDINSKTNDNENSLHLICKNKNPNLLEIIKYLISKGIDINSKTKDNKTALHYACENKNPNSSFEIIEYLISKGIDINSKTNDNETLLHYACRYNSSLEIIKYLVEKGIDINSKTIYNETALHYVCRYNSSIKIIKYLISKGIDINSKTIYNETALHYAFTFNSPFEIIKYLVEKGIDINSKTNDNQTALHYACQNENPNLSLEIIQYLISKGIDINSKTNNNKTALHYACQNENPNSLEIIKYLISKGIDINSKTNDNQTALHYACQNENPNPIEIIKYLVEKGIDINSKTNDNKTALHFACQNENPNLSLEIIQYLISKGIYINSKTNNNQTALSILIDEKRKDLIEFMIMNDANIFDLKQNQITNEIIELFLKIYSINQDMNQLLNSNDNFSDFTIQSKDGFKFNLHKLILLKRFDNNIKNLNKFIINCSKKSKEYVENIVNFLYTGFPNFHQIYQNLNQNQNQNQNQNQNQNENQNQNQNQNQNQNQNQNLNQNQNENQNQNQNQIQIKIKIKIKFKIKIKKIQNLNLNLNENENEVEEFFKEIGFDSNWINSKKGRKGIIKDLSKLYQENETKDFKIIIEEKKIKVHKLILILRSELFKGMFLNVQDSSNQVHDYSQKSFSTIHQLIYFLYHDKFEEEEEETKEITNQIIEEFDDLKDYYQLNENSIIDLLLKKISKLKLKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L567</accession>
    <name>A0A9Q0L567_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_03439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L567"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="8">
        <location>
            <begin position="642"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="947"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1078"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5066106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1221" mass="143676" checksum="C70A5BD6B6A50295" modified="2023-09-13" version="1">MNWFEIKHQKIEIIVDFDSNSLFGKTTFILFPQKTNSFQNHLSFYFPQGKISNISINNNQVPFQFYSYLKTPILEHKLPQKPLIFLENFLSKKNQKSNLILDLKNFPFLQIQQEFSVTIEYSIENPETGINFLHYNNRKFVFTHNDGNKNNFWFPIFEAEMSFTCFDILISVLEPDLFVISNGEFISKNQEGNQFTSHFQLKIDSKPESLGFVIGEFETLILPIQSNSAQIFPNNNINNQKNIEIEKNNQESKEELEINEKMEEEIKTQSICIYYIPNLLSEQEIKQYTSSFTQIFIFVQSTTTQYMFSNFSIIFLPKLLQSPLCFPSFAILDHLSLISYPLNPLKLKIEFAKVCSFQYFRNFLFVQNEFDSWFLIGISGYFANIYVDRHLNSQEYIFRIIQENEFLCNEMLRIPKIEKSLIAIDPLTGRIYQNEFLTSKAELIFYLLEKEIGRENLLNIISKLFEVEKLSDRIINIDEFFDECQKFTKSSMLMFKKQWITWDSLPKFQCSLEVKKNDLELLIKQHVVNENQHIFQGILKLRIYYQNGSNDFTANISQPIHAFKLNLDRLAHLTDSYTESKLPQISSSPLFLVVDPDHDWIGKFITKQNIDPLEYPFDSKMDIRVLYKIIHFLSRSYGRQIQTINFLISLFQDNSLFFKIRAEVASCLGKYSSAKTDWKGLDFVINYYKNNFPVLNLKENPDYQYYYLRDTIMEVLSIIKDSERNTPSDIYHLFLEILDSPIDYGNDFVNDSFKTNIVTALGNTNPIQLEFISLIFNKIRSLMENDLRKPSYEYMISQTCFRTLSRFSARVTLDPTIFHQFSQNTSKPEIRISAITSYLVATPHEEVSDLLKKILENVIENPEKEEPFFYEKLFSILLNETLPNIGRQFFQANNPSNINSVSLIWNLLNQKCNINIYLYSIVYRLYSWIWNENFVFRRQGLKSNTALKRKKNKHKNESNEIENGNEIFDQFEKEKSQENISKSRKTKPFSTSKKPKTSSAKSKTKTKSVIKPSRNSYQETRSQKRTRKKIFTNSPIIQNLSTSKKSPIKQEENPNLEVKVFSEDETYSSEERKEKNNKNKNKNKNKNKSKSKSKSKSKSKNKSKNKSKSKNKNKKDIEVEIEVENDTNESDSDNDSDSDFDDDYNDDDYDDNGSDIDIFSNKRNEMKSNLKFVLDPRPLIKFKLDTTPLLANKDREHFIRLESHSTTDRVCVKRFLYLKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L593</accession>
    <name>A0A9Q0L593_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000141">
        <property type="protein sequence ID" value="KAJ5066532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L593"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="102" mass="12460" checksum="0E7DA2EBB4261153" modified="2023-09-13" version="1">MNIKIENQNEYKIEDYDNKEYQYERKKIKAKKKFKRDYEVNLKMNLRKKIKLNSQLYSYYNLDSESDCRDDNDYTSDSEYNPESVSEKEESYSESEEDMNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5X4</accession>
    <name>A0A9Q0L5X4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5X4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="498"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="643" mass="75010" checksum="9448C9A10862D6D0" modified="2023-09-13" version="1">MTAKLISINHENIADFSQRHVFVSIISLLVWFMHLFESKFFGVVAKEIDQELLEAISLSQFIATRIIQKDLRGLSSLFKERFFPQLDLSLETTNRFLYQVCHELYRVFFAKHASYLIEILSLMIANAPAKFMKYLFEVCLIFLQESRKSPSLIPLFSKIVDTAKSHLETEFQPFASKILSVATLDTDFQNFVEHSSLNAKNPFDDSITLFNLSKIHRLKAKIKVKNQSEKQSENQNQSEKQNENQNQNQNENQNENQNENENQNENQNENQNENINKNENEFENEFENEFKIDNDIDSIDIDLDNIANIPQKHLDKNRRGSSRLTNIISKDPKKEKEKEKETTSLQIDVNQINKGDMLGANILSPIAKSIRTSNLKPISRFESYEKVANEITIPESNQALKLRKSFAPLTKYDSTLKMLQDFEQEMAEIEKMQLDEEKLMSSTESLSQTDVEDDEKTEIVLDSQNANLETEKPDQIDEEVLKMFEKEAVVDDQNDMQKLQRLFVDFNLRADFVDWLTNTESEYIQIAFDFYELVVQYILLDKRSKEKKELAQIIFNRFIAQDSIEALPLSDITRNEIEINFADEIPDSDLFQKAVFEIIPTVSNAYSSFLKSDIFLKASKDKKYKQKLESFDFHQIRRINSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5Y3</accession>
    <name>A0A9Q0L5Y3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_13471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5Y3"/>
    <dbReference type="OMA" id="VIVVHCI"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000029">
        <property type="entry name" value="Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="8">
        <location>
            <begin position="188"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5066616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="482" mass="56822" checksum="E13A41501B578CF3" modified="2023-09-13" version="1">MSKLKKLVSKQKRRINFEGFNLDLSYITNQIIAMGFPSARIEGIYRNKMSDVYNFFEMKHKDKYKVYNLCSERSYDASKFHNRVECFPFDDHNPPPFDMIMSFCNSVQAWTGQDQDYVAAIHCKAGKGRTGVMICCFLLFSETWETAEQALSFYGAMRTKDGKGVTIPSQRRYVKYFEQFLKTGIRKKQICYLQKISLGPLKKISPTKNIEKRPHFHIYNMDHKLLYDSNSKESNSFVSESKSKILTVILSQPFPLFEDMKITFYNQNRTLFVAWINTSFIHQEQLTLKKFELDKAQKKKSLPDANFYVELTFNKIEEVTEEDLIDGKFSDLITVSQCFKCEFNSLNSHLQNQSIGSDFDENENEKEEILEQDFKLLNLEEIDINSEETDIEDFLNEYKEKNQNQNQNQNQNQNQNQNQNQNINQNENQNENINQNQNQNQNQNQNQNQNQNQIENINQNQNQNQNQNQNQNQNQNENINQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L688</accession>
    <name>A0A9Q0L688_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Calcium-activated potassium channel alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_03097</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L688"/>
    <dbReference type="OMA" id="ILHENEP"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="13">
        <location>
            <begin position="336"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="13">
        <location>
            <begin position="817"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="641"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="705"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5066753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1166" mass="133975" checksum="0011745D94C066D0" modified="2023-09-13" version="1">MDDDSEISQQILQRKTKTTRNGYQVYDPNLSHGRMDTTFISDTDTSAARISEKEIRKYHVDLANQGKQKTGETEEKEPVFVSGTDIPLITPSNLKRSEKFALFLANSGWGIAIDIIQVVLSLAACVVYVVETYLYNPDSSPPNVIIVIEVVLASFFIIDWILHFYTANSKIRWVLSWFSLIDFVTIFPVFAFLLNSKSNSVVTLSFLRIFRVARVFRILRIYRIVVIQKIPLIRILIKHSFILITYIFLSTGIFQFLESVQGNDDLQFHNSFYFIILTLFTVGLANVEPTTILSKMFVVLDIIVFLILFAIGIYQVNKFFRLRSIMSKTFNHKKFKDKFVLLVYDCEETVLSSFCKQFFSDIRTQDYTILVLSQNQPPRKLDQFLKLYNKINPIKQRNIKWITGSALDENDLNRCNINFCSACFVLSNQMANNYDQEDQKTILKALSIKKHHSFLKIYVKLLMAKNKIHLFGSGIEAIISIDDLQNAMFGLSCLFPGFSTLLANLSISPFSVTQQSLVFGESSKNSKSKDENPMASTLDPWLNEFLFGFRNEMYSLTAPNSFIGMPFSQASALVYFKYHSILFAIEIELDDQMRIVLNPGSSYTISGGELIFIISRSIKSALKISRHGEALEELKKAYKKSHKKKNKMKIDPSSTSDLQIPLKNLQKSNDPKSFNQETDSEFPDEADLALRRRESVYSRQLQKVLATTQKEEENESQNNDNNNDNNNDNNNNNNNNNNNNNNDELSLESDHEDRSQIEARNIKRNLKKKMSIGNILKVDAEPQDVDQISEVYHLLDEPLSLQNQTIQNVVDDLENLNQHLIVCVNWDTIFSLSYFVKPLRQKSFPTLIPIVILSVDPPSQEAWDSIAKFPEIYFVQGDYTKLPDLRRAGIELAGQVAILCRKKTDPNDFENEMIDNENILTHLLIENNFKQDIFTITELQKPENIKFFENQKYCDYDLIYSPSFSSGKIFSPIIFDGLLIKSFLNISSNDLIREFVFPTPLPKNSTIKSSVFSEYLIPAAFVGKKFQTLFKTFISHNAIPIGIYRGKQSKKGDFSYVVLCPKPDTILFRGDRVYLLSTEYFSDNQTLAQHLLGSLQHKKSVFMKSSFVKRKKDEESQMKLDDLLEIDQKSHKNKNQNQNQKQNKVQFQDNFDELGIDLVSDPTLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6B4</accession>
    <name>A0A9Q0L6B4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ring finger domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_03142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6B4"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="105" mass="12514" checksum="CE33C0576427548E" modified="2023-09-13" version="1">MSQVIQRDFEIIEEIEQIRKEVKKIIEEDETKYKEAKKMKIKEKEEDEQKNKCDICGNPKTEICTLKVCPHTFCRKCIESYVQRKQKCPTCKKPAKISDIKQVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6X1</accession>
    <name>A0A9Q0L6X1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="419"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="459"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="495"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="532"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="569"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="607"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="644"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="680"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="808"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="844"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="941"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1253"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1350" mass="156982" checksum="6182B984260A9F52" modified="2023-09-13" version="1">MKKTKIKETPLHFVCQNINGNSLEVIKYLIEKGININEKNKNKETPLHFVCQNINGNSLEVIKYLIEKGININEKNQDKETPLHFVCQNINENSLEVIKYLIEKGININEKNKDENTPLHITCQNDSKEIVELLLGKEGINVNEKNKDENTYLHIACQNTSLEIVQLLLGKEGINVNEKNKDEKIPLECISPKDNSAKIYRLLVEKGADINEKNNDLFQSPLNSISHFNEPNILELIEFFIQKGDFPFSILNEEKPFHIICKNQTEASLKMIKYLLKIGEDINSKTNYNETSLHLACQYQTRFTIEIVKLLIEKGADINSKTLNEETPLHLVCEYQTEFSQEIVEILVTKGADIHAKTKNYGETALHLAFAKGADIHDKTKEIEETSLHLACKNDNSRSLEIIKFLIKKGAKVHETTANGETPLHLVCKYQKNENSKALEIVKFLFQKKAQINAKTKEKKKTPLHFACKFQESFLLEITYFLFKNGAKVNHKTTDDKTPLHYACQNTNRKAIRMIEILIEKGVNVNSQTQKNKQTPLHNVCFCQDLDNVSDMSKLLIEKGADINAKTEKGDTALHLVCYTNEQKKNSPHIVNYFIRKNADINAQNNEGKTPLHIACGNRRNIGLKLIETIVSAGANLEIKTLNFGDTPLLFACKWQGFNIFKIIELLTDYGANIRTQNFKNQTLLHVACENAKRKNPVELVKFLMKEGLDIHAKTIYGETPLHFACQSRNKNHLKLIPKNCLQFSCVDDEKTIEQFNEFLHEKNVKIVDGRKSNKTFFFHCEMEKGDEKEIIKYLQKEKAKILFLLKNGETPLHFACQSRNQKAYEIVQYLVKNGADVKIKTLDKETPLHFACQSRNKKSLEIIQFLHENKAKLRTETSDGNTPLHFVCMSNNPYSIRIIQFLMTRENLEESIDLDQDQPQIKPQKARVGIAAEINSCNKNKETPLHLACIFQRKSLSDVVNTLIQNGADVNLETNDCQTALHLICFHQLRYLQKLYEELKSYEKKGSDRNIDISHSSLVKSKFEKYQNRLQNIKQTIGILIEKGIELNKQDRENETALSLALNFVNIPEITHLLIMNGASIFDLPFIKISEKMINSFSKIHSINQDMYNFLKSKQFTDYGIQSNNGFKFKVHKDILLLRLDNNERLFTQFVNRCKMKSQKEVEMILNFIYTGFPNFEFYEEIEKLKDWNNQKNRKEIERKFMRISENQNKLKIQLKEFFKEIRLYLDWIQIKWGRKGIIRDLQNLYQDDLTKDFTIISEESGIEAHKLILMIRSKFFQKKCSKNPEKFFDYSRKSYRSLYQLIYFFYHDDFHHIQMNQQTIFELRDAKHKFQLNQNSNIDLLLKSFFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7A6</accession>
    <name>A0A9Q0L7A6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1427"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="468"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1446"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1793" mass="217138" checksum="0350EF97FDD06D7D" modified="2023-09-13" version="1">MIEIKELLSKKQIQKVNQIKEEYFSSIYNNFEELLNEEILKNKVKKSIIFTRGYKREIGKIEEKYSEYSFKILDLQNKDKIIKEENEELISNIPKEKNILIIHFKQNQIELFYQIKILIEQIISQNNNQNKIENSYIILFIHLSFTSNSKSFPFYFEKNWEHYYIEEIEPLFNLKNLPQNLLESFDYLQENKQIEKIIIENLGIILSKEKDLTNENFKKEKELIEKNLFKNEEMKEQIFQKIREMIELSIKSKHENFKWEIFDILHNFKQKKKKFISILFDKVKEDLIEIFDIFFQNINQNENLSILLNSKDEKMKEIWDVIFQQFEIPCYPIYKTKTIKQEFPFSSIIYSIIQQNETISQQNKIITFIDSSFNNEIIQKYLKDFIKLVLNPEQENIFQKLKINLRRIIKNYYSQQSNEKIETISFQKIQQIYFEKIHQKLINLLFISKLINFKTKRKNEKRKRFSFLLFMKELIEKIKEDKEEIIQNDNIEELFEFWIEINQKQEEKEEIEKLYNEWIIQTFQKQFSIQLKQLNPKKTRENYNYQKIENELMINKITNELIEELFSENINYKNIKICKKSQKEKKPIYLCLESNEGKCSICEEEIEENDTKHFRTIRKSKIEEYRKEIINIFHKFSEYLTFYGRIIFQQFLFKKKLTKKFNFGFIQKFLNYSIEKIEIFLKVKQIENIYSIFYPILKNLFSFIQNENSNEDNEEIINFIDEFLKNTNQEILENKPENIILISCIKIINENEEIRNKIKSIQQNLFKNQDLPNLKKESKPKSKLETKSQSKPKSKSQLKSISISNSNLNSKSKKESKPNLKEKNIMVAISKNQFSIQNIIKFIEKRKMLLRNPKKIIQKFKNSFSRKSGEIWIKFIFNEIENDKGRNYLQKFIEKEIPDKIKELEISQNILNSKSDDSIIIEYPKKNKDQSLLYYYEQKEIENDLSLQFQKTHISFVSEHKISYIISQFYRNFWEIEKEIENKEIFKMIIQSVEFIDNTKLEPFQLLFSSDLLFEVGESQLKQEILEKLYFLSMGSHPFQQEFEKEKSYWKFCEKGHLNFVKSSHIKLQNWCEFCKSNLKENEINSEFFENVLSYSVSKIPNSNPLLTYRKLNPITFRIIRLLIHSSILPFSIISEKFSNHFISMINNCVFKPKNQKELIKQLISHIENDLLIISKLTNLTNYQSILYYNETLKLFSKKKIPNFLLRKDNFKEVETRNKLEEIFSDVFKKNHEKIISNIKKKYKINKKLQQSKTKINLFDLSKPNLYPIINLYIQKKEEDFEKYPLIKFIIENYPKLEILNLFEGFIKFTSLIMKKMNGKISKEEAKVIQIQKFIETENNPIINKLYLQFEKFWKLSSKEIKYLQITKEINDDNFKYEIKKEDIIDFCLTGKENYNLMIPILIEHSINLHNELIKSPFLKSIFQDSQHNQNNEKNENNENHENNENNENNENNENNENNENNENNENNENNENQNNENQNNENNENIQGFKESILHFPKILNSDFIKIIKFNIQEFQEFINYNNLIQELDYIEEFIRKKLNYLKETNIFKIEIENFNYYGKQIEIKTEFLETEKKWEQKELNHDKWKQIKEELEKNNLFGTFGKLIEYIILGCQNIKNENKFSKLKDLSIIEFIKTKLEFQFEFEFKNLEDIENDLSKFKQFAKMKHLLFIHKQFKDNFENILENLDKRFKWEMTSFQISLLKNSLETITKNIPIFDFICVLKDFIRKLKGNLNHNYPFRKLFLFSIKDKTTNIYKEIEENFDNDEVILLGNSSHVYQFCSDIFNENQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7P0</accession>
    <name>A0A9Q0L7P0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinetochore scaffold 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7P0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="2">
        <location>
            <begin position="3"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="435" mass="51196" checksum="9708DA81D4285371" modified="2023-09-13" version="1">MINFLDSLDIHFMDQMANMKRSNSIGVGDLYNKSIQTFSDKIKEQFITRMEVETMESECETLKKITTKAQKFSSELESQIVANQPLLVNQILNCKSKKEFNQFKTQIQKLKQNCESKYKKDFLNRQNQNLQKLSNKFNKLISQISNDYFQLQKWDQFLQNNFQKLQIELSSNQILLQQKEHLQTKIEKLTQKKTQIDENFQKILEYRQEMIAKRDEKFNDRQAKTSVIDSHKKQIEKIESEAIQNQMIHQKISSLSNLSINRFTNNLISLTFFNIFNLKMAIKQEEKSRLIVQEFSMDYKSKHEEFLVHLVMSSVSKILESIQDLESLPYQIQQLTTILGRLTDLLHEIEDLEKRFPVFSTDSKGCVEFAFSSFLTQKRITVSFVISNGYPFSSIRSLQISQFNCRDLFKIINDIPIGYGLLTRICKIIENEVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7S1</accession>
    <name>A0A9Q0L7S1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7S1"/>
    <dbReference type="OMA" id="HLRINIT"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="397" mass="46579" checksum="1FFCB3BDD5B9E960" modified="2023-09-13" version="1">MNSKIEIESDPLIEKFTNEIVDLEKFISSILEKNNIEITIDKLNQQIEILENHLRINITENRKELLNKLRKINGYQNQTRSINEDASNLEKLLLKLYEQFMENYEEIEKQYIFVNNVQKASEYLRHTLRFSYLISRLQKQEKSQIKDWSYMANILNEIDALLSENDLNNIDFVEEKKSFITQVKQNILKKAEELLLNGMETHNQSNIGIAIQIYFNMQNLVPKITSTFSNAMKLTTSCIQSCLNPRSINIERDGISTSKAIIRSNMENLLSTVGKYFTQIFYLQHVLSKQKDIQSNSTIISLIEDKNIQFLSQNFWQKTCEIIDQSIRNAMNSSFFRSVLIDDYYLIIQLVNSTLEKIDRLSSLNIDANFLNDSQEKKVQVVDHNVFMICFEQIYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7S5</accession>
    <name>A0A9Q0L7S5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">T9ss type a sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7S5"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1147" mass="130011" checksum="FCB3CA9556762D81" modified="2023-09-13" version="1">MVETVLSYTYQTIMFVKGLFDTYKSNVRERKRVSDRLNKLTPSIEYFQQHIDQAQAKYATLTRFKSAMNAYYAFLQSQVKRNKIISFLSSKSTRSEFETLEKALDQCRDDFGLELNIHTNVTVTQTSLTVNKIDNTVTDTQKEIKELNEKIDKFMQFMIQSQQDWSNPSEEFYIPKDTVLERKQPLIDIKDNESYTSQFFIDKFGLDKKSTKILLDIFDIERKGSITPQEFQQRREIIEKGSVQDKASFVFKSWDLDKNGFLDIDEVKYALENAYTLIASFSFSEIYGSLVEYMKSLDPIKKNRFKKEFKSKVKDIMKKNEVGKFIQIMFEQTIKNDNDEISLEEFVKYCEKPNNVTFTFLNALSETMNSFLEDSPDETQDNIQEKSEKPENQTKESLTKHSQSLVQKIMEQQKNQKIEKPKKKKRFHFLKFKRKSNPPKDSTQNTSIQQPIQQPIQQPIQTPDKLVKEYVYPNILLLASDDREEYLSDVENSIKSNGKCVVTKINGRTSTPKYDELLNFNIIFLYADYDWIDNKQLSENLKLYVESGGKLIICSAFALATDFPNKDLVGSILDYIPLSKGVVSRNEKAKIDSNFGHKILEGVNSFDGGNASFRIKTNEVNGGQILVKWDDGTPLVTQKTVLGKGGKGGNVIVLNMFPCSTNAIPTGWDRKTNGQRLIANTIYHSFYSPKIDYILPPPPIKMPNVLIVASDDRDAYVNDVKSSIQTNGNCNISTFNGRTSTPTIKELFEYDVVFLYSDFDWIDNTTLSNNLKTFVESGGRLVICSAFALSNQYPNKDLVGNFVSLVPFSKGAVLRDGPVYLDKRYPNEILEGVDIFDGGNASFRIKTNEVNGGEILAKWSDGYPLIVQKQIRGYQGKDGLIVVLNLFPVSTNALSTGWSNKTDGAKLISNTIQHTFEYQPIILSKETGFSRANILVVASDDRDAYVNDVKSSIQTNGNCNVKTFNGRISTPIVQELNSYDVVFLYADYNWIDNTTLSDNLQKFVESGGKLVMCSAFALSNQHPNKDLVGNFVSMIPFSKGVVSRDGPVYLDKRNSHEILEGVNSFDGGKASFRIKTNEVNGGEILAKWTDGYPLITKKVIKGYQGKDGMIIVLNIFPCSTNALSTGWNNQTNGGKLISNVVKHAFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L831</accession>
    <name>A0A9Q0L831_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger matrin-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L831"/>
    <dbReference type="OMA" id="NIPIYRR"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="198" mass="23897" checksum="9CE8AC1FFD84311A" modified="2023-09-13" version="1">MTGIDETYRRKWNKEEYLKKIEERDQNKKQQLIDKIMGKKNKKRKSTGSNKEVVDINEETTRKEREKEFQNLDERIGQKITTGINDLTQGAFCCTICNRRFTDSQSYYDHMNSREHLRKAGIKVNKKKTTKNEIQELFKKKKEEIIENKTKKEKKNEEKEIEIEEKLTGKKQLEKQKQLEKQLEKENKNKNKKKKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8P2</accession>
    <name>A0A9Q0L8P2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_12920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8P2"/>
    <dbReference type="OMA" id="TIMYMEV"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="74"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="469"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="542"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="592"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="635"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="863"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="870"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="910"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5067470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="926" mass="104202" checksum="3DE6F57F5AC5762F" modified="2023-09-13" version="1">MAFRVSKFRHVYGTACKPEERYSDLSVSSKETTSNTITVSTKFFAIPAYSVSGGNVIVHSLEKVGRGTKAHPVIQGHTSYVTDMTFSPFDDNLLFTSSDDATIKIWRIPDEGLTSNISDCEMKLVGHKKRILTIKHNPTSKDILASGSLDQTMKIWDIEEGKEVSTIENIFGGEVEEIDWNWDGSQVVSVCKDTKVRIFDPRTQSEMIEGKTHVGTKSRRVCWLGNSTKFITTGFGRGVREYSIFDSRSMEKPLTNTILDSSTSILMPFFDNDSSLLFLAGKSEGTIRAMEILDSDPYCLSATAFQEGNLPQKGLAMLPKRAVDVTKTEIVKFFKVTPRFIESISFQIPRKTTSYFAKELYPDTKGPEPSQSGKEWQEGQNKEPILISLEPTNLTTDGAFIQEEPKEENQNQNDDDIKIDYSIKSKEEKKPAKKWVSPYELKKEEEAKKRGDTNEDKEIKIQRRDSPVQVVRQSLVRHTFITPGKTSEQFFGLKLQNIRPVQTNSIDVNEKFFATPLAGIGGNVGVFDVNKFGRIKPNHPIIRGHSGAITDLCFSPHKKNLLATASEDGHVKLWTIPENGLTTDLNDSTVDLSGHKQKITLIKFHPLAENVLVSNSADCTIKLWDIEKNDPVVSLSHHNDVLTSLEFNYEGLLVATLSLDNQLRIFDPRTENIENQTNAHESVKGSRLCWLGDTGFILTAGYSKTSSREVMLHDLRNFSSPLKKITIDQSAGILMPFFDPGSNVIFLAGKGDGNIKLYELQQDEKTIHYLSDYRSSSPQVGVAAFPLSARDFAQVEIARFVKLMENSIVILHAKIPRTRAEFFQDDLFPPVYYTDKSLLSAQEYFEGSDAQISKVDFCPNGMTKLSDAPQQEKKKGKYSFEVESKQEKELTRDLVLQKMYEKIDMYADSSSDEDEKKDDSDDSDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8V7</accession>
    <name>A0A9Q0L8V7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000119">
        <property type="protein sequence ID" value="KAJ5068206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8V7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="265"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="435"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="566" mass="66098" checksum="A5F2D0BEB5B96739" modified="2023-09-13" version="1">MNDCLFLAIEYLKENDSKQNPQKIEENIQKVSVGNQNEAILTIEGNVFAKGRNINPNNSKEFINISSLIEDPNDRIIEDVVSGKDSIYLLTSNQNAYAIGDNKYCQLGFDSYALNKTEKPILMMKNVSKIFSGICSAHVFLLNSNQELFGCGWNNYGQLGLGESRITKTIINKLTKIQNIPKGKIIDIQCGGFHSIMLVENENENQNPKRKLYSCGDYRLNALQKEYKDTYEFTEIKLSLFENENDYILEFSVGDQHTLILTSNSKLIGFGSNSYGELGTGNTEKDQSIPIQIELPKLRFNEDISNYHISCGFYKSFLYYYSSSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPELYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIEDEIQITKEIIDEIQIGIDYFQLNQTNPNLFDLLIKKFNIQNQKKTQNQIKIKTNKHFLEKEHFKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Z4</accession>
    <name>A0A9Q0L8Z4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adp-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8Z4"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="518" mass="60362" checksum="6FE5479E19E1995B" modified="2023-09-13" version="1">MQKNNKSFWVEKVRRCLISGLVGDAVGALFENKSIDNISSKISQEKVYVYTDDTQMTLSICEHYLLNQKLDSRNLFDKWTEASENLFWIVNGYSPKRFQFGLFRGTGNMFRTAIRNKTPSKSAGNGASKIIAPVAIAAWRNTKNIDKAIQSLQNDLFQITNLTHTNFFAFTTAYAYAVLLLYFIGSPFKKKVTDSQVNINETLKFVYQKVFEYEEYLMKSSNQPELEDPSYFSVVSSFFKLIIVDNFFEKNKKENSFDLNVGNFIKNNAELYTNQKVDKPSDGFSLCSVLLSIMLALKYHDKKYEDALKKVLSFGGDTDTLATMTLTLITSINSNCYPDEKSSLLRKSIGYSNANDMFTVFGKFVANEPSDLVLKPWIDMEEELSKELMKFEGSLGFTIIFDNQFNFLQFLDNELTQFFQQNSGLSIDKLYIQFYSQYQYLDFFKILKTEERINFFMNTYFQIQNTNLQSNQNYQQQPNYPQNNQNNQQQQQNYQQQQNYQFDNKNNPYKYNKKNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9J8</accession>
    <name>A0A9Q0L9J8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9J8"/>
    <dbReference type="OrthoDB" id="49336at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="137"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="318"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="444"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="447"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="68891" checksum="ADCAB9CF2F8882F4" modified="2023-09-13" version="1">MKNILIEKPKEDEKLKEDEKNILTEKPKEEEKPILIEKPKEEEKTILIEKPKEDEKNILIEKPKEDEKNILIENQFEIQLDPESETDTDEDYEAEIEDYEPERKAEFLLQTNRVRNEKKIKIHKSQKETKQIIALQDVINWMEEYQENVSIQANGSFFLRIYAGSNEKEQIELRKRKGSEIADEQGIDVLINAMNNFPDNDFIQLNAIWTFINVALEDVNKMQIVILGGIEAIINAMNKFKENSAIQEKGCRSLINLASGYEENREKISSLHGIETIIQAMSRFEDNQNIQLFGCWSLGSLAENVENKFEIQRLKGIDLIINAMNKFVIDQEIQEKGCAALSNIAIIEDNKIKIQLLGGINTIINSMTNFPDAQILQLYGCWALNNLSVIDSNQTKIGETNGIEVILKAMNNFPAVQLIQKHGCWALSNLTIKQKNGFKLRELHGIEAIAAAMDNFLDNEDIQKHGCWTLTNLSMESENLSEIRTQQGIYPIIRAMNFFLGNEEIQIKGCWALNSLASLTENGAEIGKLHGIESIIQAMSFFPTSKDVQQEGCCALNALTKSKMNCDGIQELNGMGVIWKAIESFPDHQEIQWNAKMIIQRLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9P3</accession>
    <name>A0A9Q0L9P3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Low-affinity phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_02646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9P3"/>
    <dbReference type="OMA" id="ILLWMTT"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="123"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="550" mass="60795" checksum="71E88A7C8FC86923" modified="2023-09-13" version="1">MNKNSDENSNENSNENSEISGEDPFSVADTENPDQELTEKISESEQSQEDSPLLPEKEEKKEKPIKCCLCYDKMNTGFKKIQIKPIPFFISITIFVVILLIPVLKEHPEAHRCLAILLFVASLWATETLPLFVTALLVPIPVVWLRVLLDDNKKPLDGEQASPQITYRFFDPVVMLFLGGFCIAQALHKYHLSEKLASIILRKAGTNPKKILFLTMMLGLFLSMWISNVASTVVCISVLLPLIRNNIPDGDPFQRALLIGIAYSNNLGGMTTPIASPQNAIAVKVANQISSRTQQIGFLRWTGIALPTAFLVTLACYFLILKFYRTKLKAIQQVKYVSEPLTYQHWVIIITTAITVILWCVNGFIDKTIGDLGITAIIPVIVFFGTGILSKEDFGKLSWPILLLMGGGLALGYAVQQSDLLHLIANGISDIVGDSWLIFIISAFSVLMVFASTFINSTVAAAIVLPIVGQIGYSNNHMKAMLVLVDLMTSGGHCLPFSSFPNAATFAVANDKGKQYLRTKDYLIVGVSVTILSYISMTFISYNIAMSFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAD9</accession>
    <name>A0A9Q0LAD9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M0811_12765</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="JAPDFW010000123">
        <property type="protein sequence ID" value="KAJ5067958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAD9"/>
    <dbReference type="OMA" id="MDFTSER"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF218">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="969"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1062"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1087"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1120"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="135"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="906"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="755"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="786"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="697"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="854"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="860"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="880"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="883"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="884"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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            <position position="884"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00008109"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5067958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1194" mass="138721" checksum="4262270EBA185B4D" modified="2023-09-13" version="1">MSDLNKNLIQKDKVEENLNEEIEKSITIQICDRNFSKLLKYPHNYISTTRYNWLNFIPKNLFEQFRRFANFYFLLAAILSFLPISPLTPFTSVSPLVFVLAVSAIKAGVEDYQRRKADKKANSALYSIYHPELKQFKKIRSDQIQMGDLIFLEKKQEIPADVIVISTSEDDNLCYIETSNLDGESNYKERYAIQETSDFTSLESFQNLSGKIKCEEPNEHIYLFEGSIQLDSWENPIALDQNQVLLRGSSLQNTKWVYGVVIYAGIWTKISNNLRSASHKFSKFETILNSLVLKIFFIQLSIVILSAFLAVVWQDKKGRKMTYLDQETTRVMLWKTIFLDSFGAYFIIYSYMIPISLYVTVECVRIVQSWFMQWDLEMYNEENGGRMVVKNSDLNEELGQIEIILSDKTGTLTENEMEIYKCSIGEKVYHFTNKDDINQLRELMKNEEQNLLVSQFFHAISLCHTVIPEYNELTKKNDFQGQSQDEVALVKAAKLVGIEMVSRKKTKGITLKKIFLKEKENIGEELSLESENEISIQSDFENQNSNQFQTFQIDSVLEFDSDRKRMSVVVLNPITRQYILYCKGADSSVIPKLSKIGNENIEKGKNSIYQFSKDGLRTLVIAYKNLEESQYLAWKNKFEKAKASLNQRVKKVHKVCDLIENDLIFLGVTGIMDRLQDGVPDTIASLIQAGIAFWVLTGDKRETAVSVAVSCNLIDKKSKIIYIEGQKKPEILSSLKNAYQTLGWKYQELELKPNDIEENEKEKEDENENENEIDEKDFEENDSSESDLNQKNSNYKNFSEIPNQEPDLQSDFSQKNEQSFSIVVTGQTLRTILSSLKQHFLNLAVKSQTVICCRVTPKQKAKVVELVRKKTNRLCLAIGDGANDVSMIQAANVGIGIFGKEGTQAARSSDYSLTRFRHLKRLLLVHGRYSFLRLFELILYSFYKNFQFILSQFWFSFFTGFSGVSLYDGWIMTLFNITFTFLPPFVFGFTEKDVKEQILMDFPQLYNLLIHPKKRRKLNFKIFSWRILNACYQSLVIFFVVYGVFYDNILYSSGKIVGFTNFGLYCAVFSIIIVNIDYALNHKYWNWLTHVSMWGTLAFLIVFLAVYSNMLTTFPEIFGVFYMAIVSPMFYLSFLFIFIACLLPTYFYLFYQRNFHPKDWQIIQEVQRFSPQRYKILKNQIDDEFQEDLDISTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAV4</accession>
    <name>A0A9Q0LAV4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-succinyl-6-hydroxy-24-cyclohexadiene-1-carboxylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000119">
        <property type="protein sequence ID" value="KAJ5068183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAV4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="293" mass="34030" checksum="AE088ABEAED55020" modified="2023-09-13" version="1">MQKTFQFNFSNKKYIFNYQIIQNENSNNFILFLHGLGCSSKYYLQEEIVLNSFPNSNLIFYDFIGHGINCKNEEIINEKESKLFEMENQAYIVENLLSIYSSKLEKLTIIAHSMGGAIAILAINQMIQKQSKKFPIFSKGVFFNIEGNLIAEDCGIITEQTIDLFSQNPEKFSEENINNLIKNACDSEISKKWIEMAKLVQKDFWVNSVKSLEYWSKNGDLFSKFIEINESSLWKVYYVYGEKSSGNLTKLKELLLNSEISLIVIPESGHFPMFENGKYFYEKIRGKIKENLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBI4</accession>
    <name>A0A9Q0LBI4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBI4"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="428"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="465"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="502"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="541"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="651"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="693"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="920"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1013" mass="118342" checksum="764B59327EEE5B54" modified="2023-09-13" version="1">MNKENYFLLFDSCKNENEKSIEIIKLLIEKGIFVNSRNIKHETALHFACQNQKNKKIFQIIKFLVEKNADINAKSKPDNETPLHLACQYQNEENSFGIIKLLIEKKAEINAKTNEYQETPLHFVCFHQKHNKSFEIIKLLIENGADINAKNKYYQETPLILVCQYQRHNKTFDIIKFLVENDTKITKILLQIIKYLVENGIDIDSKTKNNETALNYACQNENNPNLFEIINYFIENGAGINAKNKHDQESCLHLICKYQKNHKDSFRIIKLLVENGMETTSKNIFHQNALHIACQYQEDQGIAFEIIKYLIENGIKINQVANQNETALHIVCKNKNISFEIIKYLIENGIDINAKTQREETALHISCQNSNISIQIIQYLIKNGIDINSKTIDNETALHFACQNKKIPMEIIKILIENHADINTKNTENETPLHLVCQYQDNENSFEIVKYLIGNGAVVNAKADIDETSLHYASKYQSSQYSFEIIKLLIENGADFNGKTDYKQTPLHYICQNEKIQIQHSLQIITYLIEKGANINARTKESQTALHFACQNKNLSIEIIKLLIEKGIDIKIKTKYKQESILHYLCKSQVNHKNTLKAIELLIENGLSLNSTNRQNETPFHLICQNRNENSLQITRYFIEKGADINLLTKNKDTALHLVLEDQEKDDLTQKYIFQFAKILIQNGVDINLKNNQGLTPLNFAIEEKNHEIIKLMIMNDANIFDLKQNQISQEIIEFGMKIYSINQDLNNLLLKSNEDNNFSDLQIQSNDGFKFNVHKLILLTRFDNNQTNLNKFINICQLKKTKEEVELSLNFLYSGFYDFDNFYSIFQYIFNYHFQISKLQTDYDQDKILWNEFQSKSEEIKVLTEIKQESGKAIEGIKMHKIIKLFKEIGFDSKWIENKKGRKGIIKDLSKLYQQNETKDFTIIISKEKEIKVHKLILILRSELYKGMFLNVQDSSNQVHDYSQKSFKTIHQLIYFLYHDKFEFENEINEEFSDLKDYFQLNQNSIIDLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBT8</accession>
    <name>A0A9Q0LBT8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein zgrf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBT8"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF531">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="23573" checksum="A54A9793578188A1" modified="2023-09-13" version="1">MISAITNIAVDRVLEGLLELGFEEFIRIGSLKKISKKILPYTISGEKKKDIEETIKELKEMISEEDYQDENELESIKKTLDEYEFIKNNSHILYNQKMKKIRVVGTTCAATNFPILSGWKFPIIVLDEVSQMIEPISMLPILKFSCERLCLFGDPLQLPPNLAGNENYHKNKLLFKKKTQLIKIQLIKIQIKLIIYIKHYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBU2</accession>
    <name>A0A9Q0LBU2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L5-RELATED</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBU2"/>
    <dbReference type="OMA" id="CQIASAH"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="233"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="36533" checksum="696D42D21F6A7461" modified="2023-09-13" version="1">MKFIKITKTKAYFSRFQTKFRRRREGKTDYYARKRLILQDKNKYDTPKYRFVVRFSNRKITCQIISSRINGDLVFCAAYSTELPKYGIKLGLTNYAAAYATGLLCARRVLVKLGMDKMFEGVKEPNGEEYHPEELENRRPFKCILDVGLARTTTGAKIFGAMKGACDGGLNIPHSTKRFPGYKEDNYDPQVHRSYIFGQNVADYMTYLQENDEAKYQRQFSRYIKEGIKAEDLEEIYTKAHAAIRADPVHKPKEKDPNLKPKSYKKQRLTLEQRKQRVLDKIEEARKKYQENQDNDDDDNDDDDDNDDDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC07</accession>
    <name>A0A9Q0LC07_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC07"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="98" mass="12011" checksum="8A7FA8B1144CC0AE" modified="2023-09-13" version="1">MEEIKNILKNEEFEIWEDYFKQKELFEQNKKSFLENKTQETLKATNEQAIELMEKAKKVLEIIQVYSTTNMQIWVKLWGIWTEEMKWHMTIHDGLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCA2</accession>
    <name>A0A9Q0LCA2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCA2"/>
    <dbReference type="OMA" id="MRCENNS"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="342"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="478" mass="57497" checksum="8E7DCDB5DFE10CF7" modified="2023-09-13" version="1">MDNNNDNNQIQNAKPKIKNENEMKNLEKKEPNTFEIKVHKSILSSRSPFFNEFLRDRDQINKIFLNQFNKKEMESILSYIYYGNISFDNQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLDNWIEKRIRKKKIQAKIKENDKKIKLFESENQNLKQENQKKEIEIEKKDKILKQKDEEIQNLKLSFEKEIEKEKQKIKENQKEESNQNENQNQIQIQNENENQNQNQNQNQNENENENENQNQNQNQNENENENENQNQNKLLKIFSDSEIITENEYAKKLQEWINNNDFFSKMKKGFSAKRDGFNSKNWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGFNGNKGRINDSNAFIFSLRNDKGDRKPEKFTIKQGKEGNAIYYNLSYGPIFGCKYKSYFYLINIYYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCH2</accession>
    <name>A0A9Q0LCH2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_11491</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCH2"/>
    <dbReference type="OMA" id="VGSHSQF"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="119"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5069829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="449" mass="52560" checksum="A1C6EEB1ED2DC004" modified="2023-09-13" version="1">MEILDKSQFEKNLNLIAISIPAKETKFYIKEFKEYFLDIPKVKFLYKNPENPNVRILVFCENITDPIKLNGLKEEKKKILEEKSIKPFEYSVKIGYDSLTSKQVLEKILPKELELPTSFETIGHIAHLNLKENLLKYKKIIGEVILDKNPKIKTVVNKTNMISNQYRVFPMEILAGEENFETEVKCDSIRFRLNYSKVYWNSRLQTEHERLTTSLFADFSTKTPKNSPLIICDMFCGIGPFAVRAAKRGALVYANDLNPDSFFYLKLNAKINQVESNIIPFNLDAREFVKKYVSDWQTNHNCDPTQFCSHFIMNLPKLSIFFLDVFRGILSFLPSTPVYHQVQMPMIHCYCFSKEVDKEKDAIQRINQILDFQIRNFSCRNIRSVSTKKDMLCISFRLPEEVAIADNRKRKVDVDQNDGNVVEQEKIIENLIEKENEENENLEEIKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCY6</accession>
    <name>A0A9Q0LCY6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5068990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCY6"/>
    <dbReference type="OMA" id="WMAKGIS"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5068990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37962" checksum="3B6F288B6E394115" modified="2023-09-13" version="1">MLTNSFNNLTLNQRNGSTSQFYFNLFGNPIKNIHNKALQKENKNKNKNKNKKIKIQKKLPHKLIHPVHKVPVLSLIFGWFGCQPYILQKYVDLHKDLDFNSIPVTDSRLSLLFPLHYGRNFGKRVVQEILDQNLEDSYILFHCFSGHGFYNCCHFLQELRIQKNSNPKAEKLDSNITGIIFDSSPPIPSKQLIIKGVTNSFPKAPNIVKKMVKFGSNVFTKIQPTVLSHSKKIMGLTKTGEFSLEFPQLYLYSKSDNVCPYQEVEEFLANQKKIGNCVESFFWENVPHVQLFRFHPIQYKKLIKDFTDKAIIRQKNKIKNEKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD88</accession>
    <name>A0A9Q0LD88_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD88"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="442"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="68914" checksum="278589CC05889F67" modified="2023-09-13" version="1">MNEILFFGENYNPKLFKNEPDSITKPKPIQFKFKFENENENENEKQIKQISSARFYSTIFLFKNGKAIEYLKDSNPQKIQIEENIQKVTVGDRIIEDIVSGYDSIYLLTSNQNVYGIGSNQFGQLGVDTRTLDKTEKPILMMKNVSKIFSGDSAEGVFLLNSNQELFGCGGNFNGRLGLGESTDEQKIESLAKIQNIPKGKIIDIQIGNYHSIMLIENENQERKLYSCGDYKCNGLGKNDHAYEFTEIKSSLFENDDNILEIAVTYRHTLILTRKGKLIGFGNNSYGQLGTGNTKEQLIPIQIELPKLRFNENISNYHLSCGTYHSFLYYSYPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNEIEKLQGIISNKSIKESNQIFEMIYSNKIINPKLYYEIKEIINSNEKIEETMKRIYLNENENDFIIERKEKQYKFLKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNQIKEGIEITQKIINEIKTGIDYFQLNQTYPNLFDLLINKFNNQNQKHETSKLNLKSKLKSKLNSKSKSKLKSNSKLKSKSKFPSQRKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDB1</accession>
    <name>A0A9Q0LDB1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 15">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_02043</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 15"/>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="IYGSHWE"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1594"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5071061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1650" mass="195537" checksum="5DD2457B641776F9" modified="2023-09-13" version="1">MPRKNKYSKKTNTKSKKPQKKQQTQKSPTKSKQKTHTNTGFIGFSAFNSNEPSKNTTINPQFGMNFSLNDLDFLKPEMRIIFKKFAKQDPTTILKGMQDFLSFVNQESNTQNIVQLLPYWTKVFTFLAISVERKEISPFLHDIIPIWFCAQNDPANEVRKLSKQAFEMAFPKFQNRINVLNFCFKDFLLYFQNTLKLTVSTISNPRITEKEKRQEMYERIISAAIKTLSLLIQTLQENHELVDDISFEKEKTFNSRIESNSKILPDFKDILMDCFSNFIVSEFASIRTAAFHLLMVVTDNLDNVIQSNSQIFQYFLIAAFTAFKMEKDAKVHQEMWEFILIFLKKFSEKAWDLIQNENNENNENNENNEKEKEKENNKKSRKPKYQNRKKIQYTFDTIPTPKSIFQSLFHFIQNDCYNSSQYSYSCLLPFINYIPKNLIYQSFLENFFNSLWYPIEKPNAKIITKQTKPLISAWQECTSYFLSQNQNDQFSLFIHKTQILAIFPKIFQYKNEYLANQFIHILSKRQIPEEIWKPLEISIFEQIQSKQILLFEYSPKFLREIKKIPDCKINFSRIEEEFIASLMQNIKENAVLLSFFDEENITKSKWEKILNQTISISENENNDYILQIDNVIQLIKFSSHFLQNIISKEGKISILENYIFEAISKQVKGNLETLFELCLNSSLLSEDMLLKIEEYFINNLEKLDPLSLIVPILTYIFPEGSELKNWQFKLLLKFFSKCDFHEKDNDQNQGQDEDQEIDNKLINEIINENINENINENINENTNENINENINENEVHFLREEDRIKLFQMDKFQQLPFEEVKEEDDYYDSYIEDIWDIIIETFPKKFNTDYFGTEFRKQILEYIISIHNHQGSGINQVYHLITDLCFNIEQQLEVLINLCQIQPNYSTLVLLFHLIEIIGADEYLKSVEFLQGIIDIQAFLFDEHQRILLLLEPQTQKNQIHEILTDIVFPFLEKEENEKVLDELIQKGLKNAEEKGGSHILSVSIILHNLPNIWKIKSLPKFLEEKTNYFMQLMVSEEKQTQSNIPFLLCASITTSMIGNEDFLEIIYAMNYTQFLSLSFDNANISKALQHLEMMSICLCKDAHIDTELISHIVKWHNLSSENLGFISSFWKLYNHKMNQKQEIQELQEIQELSTSKDIAQHFTFYNPKIIPVFFSKLCFISIRKLFLFIVVSVFCVLNNLDPDQFDSQTENFVLKFFLNLNNLNEANIKKMEAILWILVDIIPIMPMDNFRKLFVSEIQDNLSIQNQNQNQNQNQNENENEKFYLNEKNILVDYFFNMLFSPNKSIQFATATFVRNICYKSEILDILQLTIDKMQRNKYIKNLNNFHKKLQDNFKADIYRRENEYNSFLVVWEIALDFLDSNFSEQEKGTGFIDKIRSHYAPHFFNLLLLITQVEIGLEQAETYAQSKQYLETKESNSLRKYSSQLLFLTFVKFPSTIRFWFSSITSSRLSRKVQRFVMNNISPILIQKELDEVSKMPQKSNQVIHVDKKRREITIIYKHEEFTLEIAVELPKDYPLRLIRINPSRLLGVEKVWRKWIYSMIQIFSTQDQKIVNVIRYWFKNVHKRFEGREPCPICYSIVHLTDKSLPRLTCQTCHHKFHAICLYKWFETSVKDAPDCPLCRSVWVTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDB4</accession>
    <name>A0A9Q0LDB4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDB4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="248" mass="28869" checksum="3F09A1C0B3FFB233" modified="2023-09-13" version="1">MAYYYRNLDSSEREAVDLLMNLKKAFERSFPISGVSPLRTAIKQNKEEQKAKFTRNENQHLEPQMGCPNLTVTKIPQTSARESNFFTRSKIDKNEIHKVTRHKQHKRSTSMESKGNKESYAEKMTNQIIGETKETAKQKVKRSWEDDFEHNLKNFIKRKPIPGIGLRLDMIAKYRPQYISGWRSDSSTTIHGNAPKKIRISNKLFRFLEKATGQSSKNARRSVSAYFAKLGYTNSSKYHRGRLTFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDK4</accession>
    <name>A0A9Q0LDK4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDK4"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="130" mass="15890" checksum="C438BEC1F129AE88" modified="2023-09-13" version="1">MKRIYLNENENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKEIIDEIQIGIDYFQLNQTNPNLFDLLIKKFNNQNQNQNQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDP4</accession>
    <name>A0A9Q0LDP4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="YNQHDIA"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="577"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="645"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="679"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="713"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="747"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="781"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="815"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="849"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="882"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="915"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="948"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1078"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1197"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1292" mass="149637" checksum="DF038FB74C1F0AC6" modified="2023-09-13" version="1">MNKIIEIIKENKIEKLKEICEEIIKEIKEKEKKKIIKYSIKQKVCKEIIEYLLSKLFNNDKTDINFKDKKGRNLLHISIINQSKIEIIKLLISKGIDINSKDFKEKTIIHYSIKYLQNENSTKVIDYLLSKGANINTKTRYNKTILHFVCKKDSIQIIEYLISKGVNINQKTENKKTILHFACKKNSIQVIEYLISKGIDINQKTESKKTALHFACQSNSIQIIEYLISKGININQKTRDKKTALHFACQSNSIQVIEYLISKGIDINQKTRDNKTVLHFACKKNSIQVIEYLISKGIDINQKTRDNKTVLHFACQSNSIQVIEYLISKGIDINQKTRDNKTILHFACQSNTIQVIEYLVSKGIDINSTTKWNESILHLASRHNENPLKIIKYLISKGIDINEKTKWNKTVLHYACQNKPSIEVIEYLVSKGIDLYEKTDNNDTLFHYIYQNNPSLEVIEYLVSKGFDINAKTNYDETPLHYASQYNLSIEITEYLIEKGIDINAKTDFNETPLHLACQNNSSIKIIEYLIEKGVDINAKSSEDETPLHYAFQYNSSIEIINYLIEKGADINAKTNENQALLHLVCEYNPSIEIIEYLISKGADINAKTDYNETPLHFACQNNTSIEIIKYLVEKGADINAKSDYNETPLHLACRDISSFEVIEYLISKGADISVKTTHNETVLHFACQKKSFQAIKYFVEKGIDINAPTLYKKETPFHLACQNNRSFEVINYLIEKGADINIKTNYQETPLHLVCKYNPLLEFIEYFISKGIDINAKTNKQETALHLICKFNPPLKAVEYLINKGCDINAKTKQNRTALHFASEFNSSFEVIQYLIQKGIDINSKTENNETALHFASKNNSFEVIQYLIQKGIDINAKTNKNETALHFACKNNSFEVIQYLIQKGIDINAKTQNDETALHFACQLNFFHLIEYLISKGIDINTKTNKNETALHFACKSNPSLKVIKLLLSKGIDINTKTTYNETVLHFVSKFNSIQIIKYLVEKGIDINAKTYSNETALSISIENQNQNTIKFLLMNDTNINNLKQEKITKEFISLFSQIYSFNEDLNNLLKSNQFSDLIIQSNDSFKFKVHKLILLTRFDNNETILQKFINNCYQKPKNEIEIILNFIYTGFSNFDKMIENLNSQKIQIENQEENEIISNFFKEIEINSKWIETKKGRKGIIKDFSKLYENETSKDFTIIVEEKEIKVHKLILIIRSELFKGMFLLNVSDTSNQVHDYSRKSFQTIQEFIYFFYHDNFEEDLKELILEECSDFKDYYQLNQNSIIDLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEL2</accession>
    <name>A0A9Q0LEL2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Krueppel target at 95d isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEL2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057541">
        <property type="entry name" value="PACS1/2_N"/>
    </dbReference>
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        <property type="entry name" value="C2_PACS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2" evidence="2">
        <location>
            <begin position="103"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="358" mass="41019" checksum="555A2DB66474135A" modified="2023-09-13" version="1">MNSEEQKVGIETKLFSGIKKGDIKDIPAHCVPRTCIAKITLLEIFLNEEFDFPSPLELSLSIDSGKSKLSTGAIHIPIKQEEENESKNQKQNKNTKTTIQTMKQQRKSTPITITPSKNDKKNISNKLESSNLILPFTENDSQLIYQLAYVFSFRYLHNLKYSDNILNIHLQRTKKRGKKKSTIGIGKINLADVLQMTFDSSLKLIEPNTNNLRAKINIRVVTIPLKIGALLNIQNEEVNDIDGEDFEEKDKHSSDSDDLQYLIEGPELTQIEPKQKKKRFGKLRNKLKFGARFRKGIKKKGGKQENEIISIQNQNQNQNQSNNDLNQMIKEEDSSDKEIINLTKILNKKNKEMNQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEY2</accession>
    <name>A0A9Q0LEY2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEY2"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="518" mass="60436" checksum="93B70C9CB7206784" modified="2023-09-13" version="1">MNEILFFGQNQKPKLIKNKSFMITKPIQFKFENQNQNQNQNENENENEIKQISSGILSTIFLFKNGKAIEYLSLEYFTDSNQNPSKIQIEENIQKVTIGVQNEAILTKEGNVFVKGDINSKNLNEFINISSLIENTNDRIIEDIVCCAQSVYLLTSNQNAYGIGSNNYGQLGFESIQRWKKEEKPILMMKNVSKIFSGNSSQHVFLLNSNQELFGCGYNEFGQLGLGESRKEESKIQKLTKIQNIPKGKIIDIQCGFYNSIILIEDENENPKRKLYSCGHHQYNGLGKNQNTYKFTEIKSYLFENDDNILDFSVGYSHTLMLTYNSKLIGFGWNDYGQLGTGDTNNHFIPIQIELPKLRFNEDISNYHIFCDSFYRSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTENGEIISAHKLILKYRLNQNQNENEKLKEIISKKSIKESNQIFEMIYSNSSKINPILYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKKYKFPKININNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFL8</accession>
    <name>A0A9Q0LFL8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-cytochrome b5 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFL8"/>
    <dbReference type="OMA" id="VQIFMCG"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="288" mass="33422" checksum="4B63AE7CED253DDC" modified="2023-09-13" version="1">MNPYISLFFPSPIFSIPILLLIIILITILLYKTKNQNKKEIKEIKALIPNKFQKYIITEIKQLTSSVKFVKFQYVIPTENPKKTKKIGLDIPLGHHITLRASVDGKKIYRTYTPVSYNKESLTIGLCIKIQEKGQISKFIDSAEIINSQVELSGPKGMFFCDNKPYQDIYIIAGGIGITVFARLIDYFLLSHPSKPKIHLLYTSKIKDDFIFIKKFEKISSQFPQRFQYTLQIKNQYVGFLTEEDLSSFFFPLPNDYSVLISAPIGLRKLLREIFPKLKIDDQSYYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFM3</accession>
    <name>A0A9Q0LFM3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btb/poz domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFM3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="559" mass="66794" checksum="4C0165E9BFE185A1" modified="2023-09-13" version="1">MDYGIDWIQKTFHIEKGIKFEGKTIKFKLKENKVIECPIFLVSHNCPEINVEEVDLEEIESAEEIVNYAMKGEIELKMDNILDILEGAKKINNIQILDWINEFIFDNLSRENVLDFINNSWIDSQKGLYAKMMTLISQNISFLLRNYENQLYQLGKQHFEGIVFSDLVYIENEMDFFKFIYNWLAFNHKYTTQMMVRERFYFVPKKIREQFAKYKNLIRYGLLSEQDFRIVASFGFLEDSEVNLFTKWFQSQIIYGNEDEEKAKRKTKKMQTIQDDLNKKFFLPFSPRNLNNQTFWIIPTRMRNEENFIKEEKKKMETLESVIEMMIQIQCFFHKKFPKKTAKEILNYILISHYKTSDISYSPLGMRQRMMSKKEWWGFIFTDLGDVLFVYSPESYLKNPIISEKSLIYIAQINHILLSDPQLISCCKLFPDRKLLNNFPNSISSRSFLQHSNLPIFGNFDLFFDEDLSCCFTNWGTSFLPLNLSTEKPLLVKEFDRIRFWDFLPSTIIEDSLKQNENINNANSNEEKLSDYDDSISFLDIKRFFKRKRLNVLDFFVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFR8</accession>
    <name>A0A9Q0LFR8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_10029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM214 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFR8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5071620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="450" mass="53383" checksum="20D271ADE1A92159" modified="2023-09-13" version="1">MSQKNTKLVRTKLKKKSKSNLSLFINNSKNKFKGNEQKQLQSLLQALNLHFKRHPFLIKKELTLYESIELPLKILNKNSREIITKFLMEFSDNSIIDFVPTLIKSIFSGEKEEIFSVTTRISVRLLFQLIFRLRYMIFQPQVVHELFNSLMHLERYDLLKMGVVDNLIWSFGQLVSVEPANCLKIWLIEFLPIISFEKTDKIILLKLYSFLELILQKLILNNMSEYHYKSLISPTLFEQLLRIYINEIYIKNNHEKIAKKLKKIFPLLVNISLFGDPESPRRYFIQLLSLLATSLIPLRTLVLDYISQCLERDFFCFQVWCKAYPLYIPQSNNLILHIMTESPKYKIDLKKCTELCKTFTKINKAILSGKFKQFLNKNQNQNQKSKQNFEKIFDNKFSKKDIKMATITFKAFRKKASKKRKKALLLLLLLSLALILLFLRNLFFDFIYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFZ5</accession>
    <name>A0A9Q0LFZ5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">FXNA-related family protease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFZ5"/>
    <dbReference type="OMA" id="SGPWNIT"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="59"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="755" mass="86749" checksum="7E8930D916403DC0" modified="2023-09-13" version="1">MHNSLTTKNNKETKEYILKKLNEIKEKNKDVHIEIEEQKGEGEIQRNERATDIYKNLENVVVRLFTSGSKKNNAVLVLAHFDSAIAGPGVADDGHAIATMIEMLSYFSANSKNLTKDLIFLFDNGEELGLLGADLFAAKHRWAKDVQFFINLEATGKIKGRPVLFRLNGNAYQKFHMMQVYSQHFAHPFTSSLIDDIQSFGLIRSDTDFTVLKNIALGFDFAFLDDTYIYHTWLDSLDNIQKGVLENFARDIISLIYGLEMMEDDPKMFLQKENINEQKDKKFQPIFFDFIGFFTVNIPFSYFVSIASFVLTIASLLLYKYSRAKRLMYNFMKLLLADLITIGGVLIITFLVEFLINRPFASYFSWQYALVYYGLLFMVLFVFVPQINQRSEVYALLTFIWAIALFFASLYRLGSSYLFLIWTITSLIGFAVSSVRVSYTTFDSRFPLLAFIIIVSSHLFSALITIIPFLKFFAYLVSRLPMQMGSHSDIIIAAFVCIIIILTFQALLFGFRRSYFAPLAIILLGLFLVLFFFSFFTLPYSSKAPKHVNIQHVIDIKDNTLSPEIEPNYSEMLVMTPNDGESRSLSTIALKHGFRWKKKFPNIHTSSLFGYNFFGAFFKEIPQEKSIFPTKFASDLNFKISCQKIDDSNEISIDLHSPNAFQVSIMSDSLIKSTDSDFVSYSYNFYSGLSSDFEISKKFLFVDQKENLDPLFLSIHYLDSSDDLNLIEDDLKEKIYFTRNTKTVIILKEIQCPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG94</accession>
    <name>A0A9Q0LG94_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_10755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG94"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5070685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="92" mass="10819" checksum="A2C53AE382C8B868" modified="2023-09-13" version="1">MTKGTTSQGKRHKKSHILCRRCGRRSFHVQKARCSSCGFPSAKLRKYNWAEKALRRRTRGTGRMRYMKSLPQRAKHHFRHGGIPMKKRIAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGB9</accession>
    <name>A0A9Q0LGB9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras and ef-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGB9"/>
    <dbReference type="OMA" id="FDMEDER"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="195" mass="22303" checksum="F4E7ED00D6161B48" modified="2023-09-13" version="1">MSQSKTLKILIIGNSLVGKSSLLLRFCDNQFNEDLGTTIGVDFRFATVKINDEVVKLQIWDTAGQERFRTITGTYYRNADGIMVVYDITNKDTFDQIKLWFQEIKKNAPENVVNILVGNKTDLAQQRVVSYEDGQKLAKQFKCDFLEVSAKSNSNVQESFHLLAEQTLQNFNKKKTKNRKGLKFNKDTPDKKSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGD9</accession>
    <name>A0A9Q0LGD9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGD9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="105" mass="12691" checksum="B8067D87443BB4D6" modified="2023-09-13" version="1">MELKNDLEQIILESKELKNQLPNKINLQKSIEYQEKLLKFLEDKNNNKKELNFEKVLKVYFNLVEYISECKIYISENWRLIKVMNNETMKANKIAQLFPKKIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH28</accession>
    <name>A0A9Q0LH28_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH28"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="366" mass="41235" checksum="B03BF296DA3F6548" modified="2023-09-13" version="1">MSNQQKRKETQTENQTEEKSNPKTKSNSKTKSNPQNYEPKIILKPKPKPKSKTKTNPSQKQVKSAKFRRTPLAITHIHLACRKSSDYNSLLSLLSQEDYDINAKTWNETALHIACRTGTIPDIIRALVIYGANVHEKADETPLHLACKHQADEDVIRILLASGANPNERNVFIKKFDIRNIRLILILPKKKSKWTSLHIACINKAESNIIRLLIAAGADVNIPAGFTPLHYACKENLNLDIITLLLISGADVNAQSGFTPLYLACKNNCNPMVVKILLSSRADPNPYSALHVACENSANLEIIELLLCAGANYNSKNEETPEEVCIRKQNFETSKIIKDFIENPKPFWKKHCKMPENQNNLKPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH81</accession>
    <name>A0A9Q0LH81_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ovarian-specific serine/threonine-protein kinase lok</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH81"/>
    <dbReference type="OrthoDB" id="5966500at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="309" mass="36640" checksum="3C9CD14BACEE8838" modified="2023-09-13" version="1">MNFLSLNEFYEFLSSQKKLEKTKPKLNKNHFQKEIYQTKISKQKFSNIEIINQKGYYSTILSAQNSKGEYFAIKLYKSPSLKNYSNFEKEKEENQKKPNLKAQIINRFIQEINIINHLEKNPNIIKMIDWGLTQPNLYPFIVLPLYQNSLSKKYQENQLDFSSFILKGVETLKFIHFNNVIHQDLKIDNILFDSSSNLILCDWNSALFFSDENFEKISFQKDLIGFGKILARIILGKIKGKLSIQQIKNSLKKVDEKNINNNLNQSKNLLIWKDLIFKLLNITKFYNLNDLEKFYKEIFETINEKKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHQ5</accession>
    <name>A0A9Q0LHQ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHQ5"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="312"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="461" mass="53728" checksum="E65475618571472F" modified="2023-09-13" version="1">MINRNKIRILQIANLLFPQTSDKIRNECLKEFWLVSQERNIVPIRKMVDIFGMQLFMRYSNEFITEEHFWDPLFDQLLTLKSEFGLSSLFIMYQLYQKIEGDPKRIFIEKFYRFLLACLTTTNTGVKKVAQFIMKELLDKAEIQVSGMETLNKYFEKSRDACLNIEQVKSHLSQFNLDSSLSELFEEALKDTDLSFDPSYAIVPLDILQQISQILLGKEDEITSRIQDELELKLNQKSKINLKENSKEKIKKDAKEELNENSKEKTKKDAKQKISPWEQISSEFINLEIEERRKNYETRKKQNIIVCGSLLARTPNLGGLTRTCEIFNAEMLTINDMQVTKDPEFQKISVGAERWISIKEVKMESLPQFFQQKRQEGFVIIGLEQTNDSKLLSDFEFPQKVVIVVGHEKEGIPSSLMDLMDLCLEIPQFGVIRSLNAHVSTSIAIWEFTNQSLKRTQNNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI48</accession>
    <name>A0A9Q0LI48_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI48"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="408"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="523"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="765"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="868" mass="103015" checksum="90D28760F7C7D69C" modified="2023-09-13" version="1">MKQTELNKELISKCENGTFKEIENLILKGANINSINSINETPLHLICRYQQNHQNSIEIIKYLISKEADINSLNSINETPLHYACQKNSIRIIKCLIKNGADINSKNIYNEKPLHYSCKYQQENTLEIIKYLISKGADINSKNNKDETSLHYCCRNRNKHSIEIIKYLIKNRADINSKNNQNKTPLFYSCRFHQENTLEIIKYLISKGADINSKNKENETLLHYISRLQFRKNRKKQIFFRIIQLFIENKADINSKNYRNETPLHLICKFQGKNENILRIIKYFIENKADINSLTKLNETPLHYICQYQKNEKLLEIIKYLISKGADINSKTKSNQSHLHLIFRYQKNNQNMFNIIKYSIEKGTYVDIENTENETLLHSFCKYKSQRSFEIIKYLIEKDAYVNSKNKKNETPLHLICQYQQNEHSFQIVKYLIEKGADINSKNSLNETPLHSSFQYYLTNQYQQIYEFEIIKYLIEKGASVNSRNTESQSPLHLACKFQQNYSFEIIKYLIEKGADINSKNNQNETPLYLICKYQDQKNSFEIAKYLIKKGANVNISTKYNKTPLYFAIERGNLKLIKYLLMNDANILDLELDSPITSEIIEIFNQIYSINDDLNNLLKSNENLSNFQIQSNDSFKFQVHKQFLLLRFDNNETILQKFIDICSQKSKEDVQIALNFLYTGFTNFDNYVKLFHNLFDYSNQYKQNKNKNYFNQKIQKFNNLFQKENEIILTLFKEIGIDSNWIEIKKGRKGIIKDLSKLYKENETKDFKIIFDKEKEIKVHKLILIIRSELFKGMFQLNVQDSSNQVHDYSGKSFQTIQELIYFIYHDKFSKNIKKEKEIILEEYFDLKDYYQLNQNSIIDLFLKELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIN7</accession>
    <name>A0A9Q0LIN7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_00704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIN7"/>
    <dbReference type="OMA" id="EYRGWTA"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="409"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="496"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="538"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="637"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5074076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="712" mass="81189" checksum="6CACDC48B121FFDA" modified="2023-09-13" version="1">MDLKENENQNINQNINQNQNINQNQNINQNENQNQNQNENINQNQNENNNQNNNQNNENNNQNENQNENQNQNQNQNQNQNENNNQNENQNENQNQNQNQNQNQNENNNQNNNQNENINQNENENENENENENENENENENINENENQNNNKNNNQNENQNINQNNNQNNNQNNNENQAIDLNQVFEPNDPRIKEDLLRVIHQYLQNEGFTSTALTLQDEALAQTADQIKTRNHFKKIRKAILDGNWSETETLCAKLTTATTRKSLFYEVYKQQFLELIDAQEFQKAYSLLNKSIKPLEGITQKKGEFSELCYLLTCSSVQESEMFRNWDRHLSRKTILKNFRSIFETQERSTQPPTEVTPNRLIVLLQQAITYQIEHSTYKPLALPKITTLLEDFNSFVLPNTLNTIFRGHRDAVKCIEFIENGHHNAQIVTGGGDNTIRLWTLDSPESQKILLGHSSRIWDLSLYNHLIASASGDETVKIWNPALDSRPCVSTLQVHKNSVYAVEFTSDGNRLASGGYDKKINLFDVLTGSVLNTLHEHTGLVSTLAFSSAGNLVISGSKDKSIKFWDVRSGICVATYSTHLGEVTSVSLSSDETKILTGSKDNANRIWDIRLAKPIMRLKGHQNTSKNFVKCNFGPNQRVVIGGSEDGFVHIWDVESGNILQRLGSRGAGVIYDAKYSSSFGILVSCGDDSNAKSWSFSPSQDILDNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ80</accession>
    <name>A0A9Q0LJ80_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ80"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="9310" checksum="D17A723275D548B0" modified="2023-09-13" version="1">MFLTVTEDSTNEVKDYTGKSTKALEMIIKFLYYDEIEKGLEMNIYEELEEAEEFFQFSEYSLFKQKLNLAKKELKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK41</accession>
    <name>A0A9Q0LK41_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK41"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="377"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="482" mass="56487" checksum="CADD17C599D73084" modified="2023-09-13" version="1">MNINPKNPKEFINISSLIEDKNDRIIQDIVSGIGSIYLLTSNQNAYGIGLNNFGQLGFDSETLYKTEKPILMMKNVSKIFSGNYSNHVIFLNSNQELFVCGYNKYGQLGLGESRKEEEKIHKLTQIQNIPKGKIIDIQYGWAHSIMLIEDENQNPKRKLYSCGDYEYNGLGKNRDTYEFTEIKSSLFENDDDIILDFSVGNFHTLILTSKSKLIGFGDNLFAQLGTGDTNNQLIPIQIELPKLRFNENISNYHVSCGYYNSFLYYSSLSFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNKIINPKLYFEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVRDYSELSNKSFQILEYWIYSNQIKDEIQITKEIIEELEIGIDYFQLNQTNPNLIDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK84</accession>
    <name>A0A9Q0LK84_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear receptor co-repressor related ncor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK84"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="103" mass="12382" checksum="3B77351666048880" modified="2023-09-13" version="1">MNWTKEEEDIFMEKILIYYKNFSKIASFLPEKTSKDVVAYYYLNKKKLNLKEKVKSKAPYLLKAKTKITQEGPPHPQQRKKIPEDEKEIKPKKSRKRNLHDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKG7</accession>
    <name>A0A9Q0LKG7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKG7"/>
    <dbReference type="OMA" id="MNGVKVT"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5073058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="229" mass="26737" checksum="A02414C39AF26EB8" modified="2023-09-13" version="1">MSFLFILILLIIIIIIVGIIWWKFIHKGKKLKTIMILGLCEAGKTVLYYQLKDGIFVETQSSMKENETRTIKLKKKNKDEKESEKNKEVHLLDWPGHARLRGKLDQFYPILDAIIFVLDSSDTQLETITSTAEFIYQIFTDPKMNMSPIPFLFACNKSDLYTSYSPSKLKQIIQVEFNRIKDSKTDKIIQNQKSFNFDKAKFFNQWVSISAKDGKIDSVYDFLEKQLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLI0</accession>
    <name>A0A9Q0LLI0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLI0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="101" mass="12080" checksum="D5C5806225C67DA0" modified="2023-09-13" version="1">MDKMIECRTEVFDRNIRNSGNIKSQKKKEIEKEIKKKKNAIKKKKQMKKNNQENHQENNNNQENNKENNNNQENHINININNQENHCGFTTDISNSSKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM29</accession>
    <name>A0A9Q0LM29_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM29"/>
    <dbReference type="OrthoDB" id="49304at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040271446" evidence="6">
        <location>
            <begin position="23"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="472" mass="51432" checksum="221FB73B057008DF" modified="2023-09-13" version="1">MKIKNILIIQITIILLLKQTESYSWLQKQRITSNPIQNGNRFGFVVSTYNNEAIISAPRNNDSRGAVFLYTKDAGNNWNQTGIITNDIYPEEIGRSLCMSEDWIFLGAPYSDDYVGVVYVYQNVSGIWTPFQNLSEQDGEYGDQFGYSVAVGGNYLAVGAKEDDQAAGLAYIFTFTGTKWNMSKKLIPPDYAPGNYFGVAVAASQNGWVFIASNCTDSCKGAVYAYKEVDGDWNYTQKITASDAQSNDLFGSSLAVDGDNLLIGAYGRSSKTGIVFHYVLQDDLWIQSQKIVADDAAVGDRFGKAVSIQGALAFIGAYGYNNSAGAAYYFVLENGTWNQQQILTASNPTPNVYFGYSSSIFAPWVFVGAFAGDQVYSFYYNGPIPPSPSPYPSPSPSPSPSPSSSPSPSPSPTTNSVKSSNLTVILVSVFIPLGVIGLVLFAILAKRRQKKKLAKIRQEIFQENSANPLGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM47</accession>
    <name>A0A9Q0LM47_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM47"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="309" mass="37336" checksum="B8E534974BD0AD90" modified="2023-09-13" version="1">MKQRKFKNNLKDFDSITENFNFSQINEESIDEIDEIDENDLNSNNTINLNFFSKKNKFQTPKLLNQNNPKKKKKINELSKAQLNLEMYNQKIIKMNSEIEILKNEKNQFEKQISTSLKDNQNIINQFLEIINNFGNQKEIQTFSNVSFYDIDEKTWKKLIQKFKKKIQQKQNFKKTNQLNLKKFSNELKELKEISKKSNQNQNQENEMRKINEIEQKIQILKMEKEKSKIKYSQLQKEKQKIIEKKEENIEKQKNLKKLARKNKVSIQKMNEMNENKEFKELSKSFERIELYVKRFENIQESGKIIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMI9</accession>
    <name>A0A9Q0LMI9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMI9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="49"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="72030" checksum="8DBA8C5F5DB2F094" modified="2023-09-13" version="1">MDNNNNNNQIENENEIQNENQNEMKNLQKKVTKNLIEDYSNLLNGNSFKDFSIFVENESNPFEIKVHKSILSSRSPFFNKSLRQESLSISLNQFNKKEMESILKYIYYGNISFENQENLFQLLEISIYFKLNLLKEFIQKKISNSINYSNFFQILFQNRNLNLNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNERLKGKKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLNQFHIFLPNSFLINLERNIFQIQDLSNQTKIKEKDKQIKEKENKIKRRDKRIKLFESENQNLKLENEKQKLDNEKKEKKINSKRKEISKLRSENQKKDKENQKKHKILKEKDKQIQNLKLSFEKEIYQENQNEKEKSNRKENKILDIFSNSKIIKDIEYVKKLKEWINDDESFSKMRKGFSAKRNEFKGKKWHKAVDDKGKTLVVIKTKDNFIFGGFTQVGWTNDKSKWSFDYGNWGYIPDSNAFIFSLRNDKGDRKPEKFTIKKRSKEFAIFYNSISGPILGADFGLFDNLHHGYTKFGSSYNLPNGIQEGTDEAKSYLAGSFDKWKVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMM9</accession>
    <name>A0A9Q0LMM9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMM9"/>
    <dbReference type="OMA" id="CEINYRE"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="463"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="630" mass="74164" checksum="AE35C7BC20772D04" modified="2023-09-13" version="1">MDHTFQKYQKEAQKLLNAKTRPHFPKHPQLLRKVTKEIGSLSTQANVQVSKLESLVNGYCQLAMDCLNNYEGLILKKEDKREADLILITNPKQIKIKTESLNENSNENSKKNLNENSKKNLNENLKENLNENLNENSNQNSNQNLNDNSNESQKESTITNENYLDSISESTREIDNKNMDENEVDDDDFIELDFSKDTFSFDKSRGRSERSSKKLKAKNKYEKLFQSQISKIRETPDLDLSLQRYLYEAEGVNQELNQFLNMYSLYQSNITKKKLKAEGPKIDTIQKFHQDISLTEIQHINLIFGLKMRKVAERKKKISTKNLNKREEKLNEKKQILNNETLKMKDEDVSWDGEMLSENVPREEQIQSIKTHINKIIGSEAHPISRALKRFKMRIQKNYNMDLKQAKKEIRIFCENSAQFLKENFAFFDESTKDVNRSRALIQNHLVKSIYEFLFPLYVQEFKKQNKIIENQLKKLENHTLADFKVRERFWLIPEKSDSVNENTENQELQIYQDPYIKAIVSFQTIPKLYSPIKKIKIILKIKDEIEEAITEFYKDKEIKPGYCDITADDNLQLFLYTFLKANIPSPYSEMQFLNDFIPEEYLLGELGFCLANYQSAVQFFVNKDQNERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMW7</accession>
    <name>A0A9Q0LMW7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMW7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="275"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="444"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="549" mass="64112" checksum="828DD30C899B0EC4" modified="2023-09-13" version="1">MNDCLFFGRNKYPILFKNEPERITKPIQFKFENENENENEKQIKQISTGDFGTIFLFKNGKAIEYLTEKDSNQNPSKIQIEENIQKVTVGVQNEAILTKKEIIIQDIVSGHYSIYLLTSNQNVYGIGSNEYGQLGFDSKTLPTTEKPILMMKNVSKIFSGNTSQHVFLLNSNQELFGCGLNVYRQLGLGESRTGAYIQKLIQIQNIPKGKIIDIQCGSIYSIIKLYSTGYHQYNGLGKNENTFEFTEIKSSLFENNNILDFSVGNTHTLILTSNSKLIGFGNNEYGQLGTGNTNYQLIPIQIELPKLRFNENISNYHISCGYYKSFLYYSHFFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEDIQITQEIIDELETGIDYFQLNQTNPNLIDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPS4</accession>
    <name>A0A9Q0LPS4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase trim56-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPS4"/>
    <dbReference type="OrthoDB" id="2435505at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="218"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="406" mass="48071" checksum="9DCC6B530C41130C" modified="2023-09-13" version="1">MKEYQENKLILKDVSSSILFSILDYFYSGKIEINLENAVEILVFSSKYLIDELIEICLNFIKNNLQIETVVDILKLSESMNFNILIDSSYQFIFDNFDKFIKTSFFLELEENHLNLILSNNCIEIDEFELFQTIIKWGKYKPDINQISNIIDKIRFIDFSKQELEDTLKEDLIPKQISQKLIQFQKIQMNEKELKQFIQKENRNLLIFKSRFRLDSEIIQEKKHFKKLKEWINDNEFFSKMKKGYSAKRDGFDCKKWHETCDDKGKTLVIIKTKDNFIFGGFTSVGFTDDKSKWNEVWRKYKTGYIVDPNPFIFSLRNDKNNREPEKFSVKQGDEVFAIYYGLDYGPIFGGGWDWHLNSNLQSGNSHFGNSYVLPDGIEYDSDEAKGYLAGSYDKWEVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ80</accession>
    <name>A0A9Q0LQ80_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ80"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="303"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="467"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="530" mass="61711" checksum="3AA53A65B67C2D1A" modified="2023-09-13" version="1">MNEIIFFGWNQYSYLLQNKNSIIIKPIPFKFENEIRQIKQISTSNFSIIFLFENGKAIEYFSSSIIKRKIKIKNIQKIFSSELNDSILTLEGNAFIKINDIDFSNPKEFINISSLIEDTNDRTIQDIVSGEGSVYLLTSNQNAYGIGSNHNGQLGFDFQKFPKTEKPILMMKNVCKIFSGNTSLHVFLLNSNQELFGCGNNFYGQLGLGNDGYFISDFIKIKNIPKGKIIDIKCAKYISLMLIENENQKRKLYSCGFYGSNGFSKSRNVKKFTEIKSSLFENNDNILDFSVGIHHTLILTTKGKLIGFGKNAYGELGTGDTEYQKIPIQIKLPKLLLNEDISNYHLSCGYFTSFLYYSPSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEAHKLILKYRLKDEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQA8</accession>
    <name>A0A9Q0LQA8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQA8"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="95"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="448" mass="52635" checksum="E52816F14F969AD8" modified="2023-09-13" version="1">MENYSDLEKLSNDLKNLFQNQNEKEEESYFDFEIICEQNKTSFKTHKSILSSRRKIEINLENAIQILIFSSKYLIDELIEICLNFIKKNLQFETIVDVLKLSETMSLNQLLESCYQFIFGNFDKFIKTSFFLELEENHLNSILSNDELTINEFELFQSIIKWGKHKSNINQEKELEKEEKEEKEKLQNQISNIIEKIRFIDFTKQELKDTLKEDLIPNEMFIKLTHFLLSQKNEKVFKELIEKENSFIFKSRFKLDSTIIQDFKYVKKVQGWINDNDFFSKMKKGFSAKRDGFDSKTWHKAVDDKEKTLVIIKTKDNFIFGGFTQVGFTNDKSKWIKVHSPKEGGDINDPNAFIFSLRNSQGDRKPHKFPIQQGKEHLAIHSYINYGPLFGSGHPDFYLKYDLRGGHSNIGWVYNPPDGITFGTDSGKSYLAGSHNSWVVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQN8</accession>
    <name>A0A9Q0LQN8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrosomal protein of 44 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQN8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029157">
        <property type="entry name" value="CEP44_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15007">
        <property type="entry name" value="CEP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal CEP44" evidence="2">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="36852" checksum="AA06D8DCD94F0855" modified="2023-09-13" version="1">MNLLEKEINIIKYPKQITFQQIQSGNPEVFVEILRYLVTKVSRTLQELLKKKNYNFSRNINSQQFITEIFHDLKNDLKNDLKNDLENDELYETFEKTKEKNNLNNLQNINDISNVKWTEPVVTQIYGDTTSSSNSSLSRSSSFEKQNDNSNFITELSYQESLNKLSEMFQKQFDLLNQKFDSSEHQIESCFNKLNSRVSEIHSELQHVKIDLLSTLKSNRFGKTEEQPNKKLNQNPIQNPIQNLNQNSIQNLNQNPIQNLNQNPIQNSIQNPIQNPIQNLNQKIPTLSNRLENRFKFQRKDFNFNRFQNEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRP9</accession>
    <name>A0A9Q0LRP9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRP9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="23480" checksum="525D0DE488A237D8" modified="2023-09-13" version="1">MILDNRTLRVFIHLIFYQFHDLETRDEFPILRIEDFLKRERPNLISDSIKKHLSKRINHKFSFQVDKTFKFPKKKEAKEATDNQNVTQNENLNQIDLEKEDQQDYKSEDQQIYQEKQSLIQIFKIFNLKTILETVPDKQLTFRGTYLSSYEKMNFPKKVFNFWKEVEHLVQDPLFQPRQIYQKIVEKNTLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRZ1</accession>
    <name>A0A9Q0LRZ1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_00148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRZ1"/>
    <dbReference type="OMA" id="VCLLNEY"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5076830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="194" mass="22400" checksum="4629728C484FD9D1" modified="2023-09-13" version="1">MDLKQTKHNIVDRPFSKESHQINLSTFTFLFSQFVQYSHERVDNPEAFAERLSRSGQAIGVRLYEYTCFRAEKTPKRECKVQDILLFIKKEIWKMIFGRPAEGLVKLPDDQPQHYYFLEANQFENQFTTALYANGLKCAPFVSGIIKGVLDSANFPAVVMAATITHNDQDSSMDKKVGYFIKFDPSVLQRDEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRZ4</accession>
    <name>A0A9Q0LRZ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor e2fc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRZ4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="220" mass="25809" checksum="BAB4431BE6CA9FE6" modified="2023-09-13" version="1">MSTPLHKRKVKEHQEQQFLSQKKSNVEKISEIISFLNRWDQGFIDLEKVPRLFENPSLFFQVLDVLEGFGIFSKTESGYTKNTQRDIDQLVVPSNFDYEILQMKQEINKLYNQELFIDRCIEMMQNEPKQMIEKINEKNGIALEDIYKTPELEQQKVFVVKANKIDLNVPPPQNTPTGKIYSLKLTSDQPLEIMEQKKTDSEIGNNSEKENIEVSIRTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSX5</accession>
    <name>A0A9Q0LSX5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSX5"/>
    <dbReference type="OrthoDB" id="5803672at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="309" mass="34816" checksum="99EAEEA61397F2B9" modified="2023-09-13" version="1">MLSEEDCSSIDIQSLSQQSDYQLVYFYDHDSFHHYCILYEVSQSTGLGTFVVNLAGTIPVSIGIPHPIYDSNTELQGAGVFKKSGAQTLLISGIIRNACNQTSECQSGYYVTDPAHNINNGFFEVVMMLKEYYEQNNLPLLHLQLHGMSEASCSDIDVLLSSGLKIKPDNNSFLSKFTSQLRTQVDSLDDPWFIFLYQDDTLHDSCDLYGTSNTEGRGLNGVDSSLVCSTSSSFISHSFIHAEQKYFIRQNRSYDLFWANALKYSYSSVYCLPIRDNVGGSCLVVDSSSLINFSQFLFLFIFFIFFIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTN1</accession>
    <name>A0A9Q0LTN1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTN1"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5078490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="162" mass="19341" checksum="B11190CE8C6380AB" modified="2023-09-13" version="1">MRENPLANTPNDRSNINFFEKGHGNILQAAPTQTELGHQEIQKRKELLKQQKRQKMIEKYGGKEHLLDGTKSSLIFGQTEGFVEYTRDGRIIKGRDMPKVILRDKQEKEKDEQKEKDEQKEEKEKEKEKDEQKEKDEQKEKDEQKEKDEQKEKDEQEKDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUI6</accession>
    <name>A0A9Q0LUI6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUI6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="186" mass="22779" checksum="2834DDF040E9EE20" modified="2023-09-13" version="1">MNISQQNFDRLKPNQKFIRKFQNQFLEDEEKGKEMNQKEKYILQPKEENSIQLLKKFLNRRKQEIQQYSENLKQEINNILNKKGKGNENMKIRELKVIGNQIEEYEIEDILNLFAHFEKEPFQFLNPNLKEEDIKKLFGIMIIFLQTEILNQKIIRTLNLCENFKKYSQNWKRKKNEEIKQIEKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUJ6</accession>
    <name>A0A9Q0LUJ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUJ6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="75" mass="8849" checksum="39F04D8A90D1CF9E" modified="2023-09-13" version="1">MIESKVMFFVWRYKITECSVFKKRKNSLSIPKLYFVVDNDFSHDSSLMKKRAIQTSFGLFYTLDCFPDGIDPKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV04</accession>
    <name>A0A9Q0LV04_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gtpase-activating rap/ran-gap domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV04"/>
    <dbReference type="OMA" id="ARTWIRY"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="165"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="389" mass="44788" checksum="8E6C968DECE2D3F0" modified="2023-09-13" version="1">MTNSNTKEDPTNNIKIGISNKINQQESTHLLEIELEKTEIWKLETFIEKQEKKTFEFDLSLPFQDNFLKNDHDNYVLNHPEKGYLVVSVMEIVKDKEKYYKILEHSQTGIRIKEISKSDIGNSFMRGLFCMGPSISNIFKKVEPSYKDTSITFCDPGIYEVDNDLIEMENAMHVKTYKFGVLYAKEGQITETDILSNETGSPAFDDFLNLIGEKIELKGFKGYRGGLDIKSGGSGKHSFFSKWKNFEIMFHVATLLPTNDPKKDPQQIDKKRHIGNDVVVIIFLDGDVKYNPETMASKQNHIFIAVRPIKSNNSGKTNYLFDVCRKNEIEQFEPMLPTPPIVTNENLKDTLLSKACSGERSTIMSGSFGERFKRYRKNILEKIYEEYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV72</accession>
    <name>A0A9Q0LV72_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fam11a b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV72"/>
    <dbReference type="OMA" id="GHESISW"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="456" mass="54312" checksum="150CCF2037D86D35" modified="2023-09-13" version="1">MKKIIYFFFDNNFQNLNNLPDEDPFINLPNESKQSKKNNKKFFSYFCFSLVLLEIFSYLDSPFYLGICSQVNSQFNLISDDVFLWRNCVRKFSPLIDFEKIAYISQDFHTLTYMNSLGLSYYFKSPEDQRKNLPISKQIMENPKKLFLDQITKIKKQKKRTKFRKMNQRKEKKVHHILYGKINHPLFVFLSFFCLTFIPLILINLRIDNEIRSSWVASFAPLFFVLAHFAIFSFFSFLENYYRRENPFWIDLSNIFASFLLIVFLVIFGLKLDQKSFKDVSLLVVCIPLYLITFLSILFVILEIREEKRMSERESRFILPKVIFYLHFQIYLFSLCISSFILSAKFDFGHESISWKSAFIPLFISSFSPLIIMLVFLIISFVKEEMNDIYKTIQIINFVNFVIALFFFGVEWMFSRKMDGVSYQNFAVVFLPLYILYACFTLFLCLLICVRNCGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVC8</accession>
    <name>A0A9Q0LVC8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVC8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="278" mass="32805" checksum="BA2EA1477823B627" modified="2023-09-13" version="1">MGKSFYVLQFNDLFQSNSFVQTFNQIQSYSLTQKISENIENYFYFLLLDSVTEKPIFGSTVYIQDEGIQIVYPNENIFIAYNNFSKVLKNSEKSSQIKLFLEENKWMLFVCQNKQGLTNFFNHFHTKRDAKLKELGISVYLGSEEQKKLEQIFQNQNQDEIEIPGEKENIPKNTKSYPVIFIENIGKLTLAKMWIESNLEIPSFDLMFFSETKKTNFPIRFNSLLKKHPEDELKCKFQTDSASLIFKFLNSKERDDFIQEFLTFKSSIPQISPFQLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVX0</accession>
    <name>A0A9Q0LVX0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVX0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="69" mass="8056" checksum="75A84E64D00B2637" modified="2023-09-13" version="1">MNTKKGEEEEKDESSFFGDTYYKFIHLVAEPFVYGVAIGFGRSFAKAVFQKWVSPILQPNKNEYEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW26</accession>
    <name>A0A9Q0LW26_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cramped protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW26"/>
    <dbReference type="OrthoDB" id="515799at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="326" mass="37885" checksum="EDC56DED71EC0F70" modified="2023-09-13" version="1">MPKSKLKSKSKSNKSNKSKSSESTEKQFVIRLVPKEQEQANILIESGHIPYLQLSMKSTKPLRSVLEHLNRKWKEAFVKSPKYDSYVILFPVSAPKDRAGWCLQNSDGVLVRDLAEDNPIQGYLSLEYFWKIEQKEEKNTNENLKENTIENPKGKPIENINQNSISNFFANSFNNIDIPENEKKYNKNIKRGKKAKAKKGEKNIKQARRKRKKKSKIRNEKPSQNKIQEKKFMEQFSRAEEQEKSSKKARMLKGKNKISNKMKNKLSAKKNRQKSKQENLFPNNDSNLGNFANNFSNTKMDSILQLDSTPIFKPRIAAEYKLIRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWF6</accession>
    <name>A0A9Q0LWF6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-like protein rasd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWF6"/>
    <dbReference type="OMA" id="CEFTEAS"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5079804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="191" mass="21939" checksum="9308D7BB0073E4A9" modified="2023-09-13" version="1">MNEYKLVVVGGGGVGKSALTIQLVQSHFVDEYDPTIEDSYRRQVEIDEEICHLDILDTAGQEEYSAMRDSYMRSGEGFLIVFAINSRSSFDEVPMFKEHIYRVKDTEKTPIVIVGNKSDLENERQVSSGEARDLAKTFGCPYFETSAKSRINIEESFFGLVREIRKVRNPEIEKKVQKKKPKKRKLRCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXC9</accession>
    <name>A0A9Q0LXC9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000024">
        <property type="protein sequence ID" value="KAJ5079620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXC9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="123" mass="14222" checksum="137FFC8ADF31E96B" modified="2023-09-13" version="1">MIKGKKICKMRMKINYYMQGIKFRIENRSLPVSLKEGVRTQIKMTLIKKDHIAYFVVFRVNAPMSFNFTSPNAPAFGLSATLRRGGSVDDLGLYTKTTNVAFLIYFFSLLFLYCSILIRIINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXS8</accession>
    <name>A0A9Q0LXS8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXS8"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="466"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="770"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="1078"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="384"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1261" mass="149977" checksum="84EC8D545AFB4FEF" modified="2023-09-13" version="1">MSKRFNYKQNKMNKKWKTKKNSKRNPFNSNYSNHIQQNQKQYPNRSRFQYPNRNSQNEKIQEEVKKEELKEELKEELKEESKSISKEKSKSKSKSNSLTDSNKTSSNEEISEDSETDEYENETEDLIEIKNENQTIFKEKLINDFQNLFENENNNYSDFIIKSGKKSFQFNSHKSILSFRSPYFALLLKEQLNQIEFLEIRKPIMKKILKYIYTSQIQISKSELIEMWIVSNQFQLNSLSKFIENEIIKNINEKNVCDYLSANQKMKSNQLENKCLKFIINNFDKFIQQNNFYSFNQEQMIALLDKLNKKKTQIGIELFEMIKKWIERNEQKNNNEITENDQKKNQKKIIEELILKIDIKSIKSQHLEKIQQMNFLPKSFVIKIQKIQEEFSQKQIEKIQKEKEEIIQKEKKQNEIIQKIENEKKEKDKIIQKIEKENQEMKPIYEEMKPIYEEEMKLNKIFGKSKIIKEIKFMRKLKEWIQNEEFFNKMKIGFSCQKDGFSSQTFHSKCDNKGKTLIIIQTTNKYIFGGFTEIGFISGSNRYIKDSNAFIFSLKNPKNNIPQKFEIQKGKEGYAILYTKNDGPRFGQYQKNENSNYYPHNYFHNYSHSEQEKKYDIRIKSDLKSGNTDFGATYSLPNGLKHGTNEAKKDSNEEISEDSETEKDEIKKKSKSKSKSKSKSKSKSISKSISKSISKSKSISKSKSKSKSNSLTDSNKTSSNEEISEDSETDEYENEKEDLIEIKNENQTIFKEKFINDFQNLFENENNNYSDFIIKSGKESFQFNSHKSILSFRSPYFALLFKEKLINQIEFLEIRKPIMKKILKYIYTSQIQISKSELIEMLIVSNQFQLNSLSKFIENEIIKNINEKNVCDYLLTNQKMKSNQLENECLKFIIDNFDKFIQQNNFYSFNQEQMIALLDKLNKKTQIGIELFEMIKKWIERNEQKNNNEITENDQKKNQKKIIEELILKIDIKSIKSQHLEKIQQMNFLPKSFVIKTQKIQEEFSQKQIEKIQKEKEEIIQKEKKQNEIIQKIENEKKEKDKIIQKIEKENQEMKPIYQKMKPIYEEMKLNKIFGKSKIIKEIKFMRKLKEWIQNEEFFNKMKIGFSCQKDGFSSQTFHSKCDNKGKTLIIIQTTNKYIFGGFTEIGFISGSNRYIKDSNAFIFSLKNPKNDIPQKFEIQKGKEDYAIRYTKDDGPIFGQYQENYYDNDIWINSDLKSGNTDFGATYSLPNGLKHGTNEAKSYLAGSYKNWKIEEMEIYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY31</accession>
    <name>A0A9Q0LY31_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Orm1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000003">
        <property type="protein sequence ID" value="KAJ5080731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY31"/>
    <dbReference type="OMA" id="WTAYILI"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5080731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="159" mass="18642" checksum="23656C33D1D2FDAB" modified="2023-09-13" version="1">MIKVGPEDSIPQRIEPLTNKSINWAGDKFFWIFYVWIIFGFRIFLWMIGIEDSAAAWTATNIVHSVVTFFAFHWIKGTPFSYDQGIYDKLTFWEQIDCEIQNTWTRKFLLIIPIVLLLITCNHTKQNTSLMMVNVFFASFVIIGKFPAMHRVRILGINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4Y0</accession>
    <name>A0A9Q0R4Y0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S27-RELATED</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_13629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000143">
        <property type="protein sequence ID" value="KAJ5066431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4Y0"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="83" mass="9347" checksum="72F7C65A15F167D3" modified="2023-09-13" version="1">MVLEKDLLNPKRKDEKQKHKKKRLIPTPNSYFLDVKCHCGEVSTLFSHSNTVVKCPSCNRVLCTPSAGKAKITPGLQARKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R707</accession>
    <name>A0A9Q0R707_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein iws1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R707"/>
    <dbReference type="OMA" id="REMKEMW"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="4">
        <location>
            <begin position="286"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="489" mass="57192" checksum="9E940695B9500BD9" modified="2023-09-13" version="1">MENNSNQTEKINLNENPNENENKIEEINDLDELSDQIEIIQHENSLSDDENDLSTLRTKNKEELEKEIEKEIEKEIEKENSVENSVENSIENSDDSSDDYNPDIEKDTEIKSQDEKDKENSIEEENLDGDNDNFDINLKKLQRKDKKKRSTKKKRRKSTKKSEDSNTKRKKGKRKKGKKGKSGKKRTNSKKRRNSENNDRIQLGSEEEEKTPKQKKNRSRTKRTEEEIESHMREILIQMEEANEKDIELNRISKPAITKLQLIPQVSPHLNNHENHNALISCGIFEVIKKWLLPLPDLSKPNKLIQKFCLEIISKFSISTEILKETGIGKIIREISLSSDPSSPVGRISRELLDKWIRQALDLQSDYKKMWENQAKENYLNAPTLLESNVDSDNENENENDNVNDNDNSVFRSNKNVRSNRKNKIKTQNLDQILNRKNKNQSISQNVELPQVPLHDFIRLPKSLISDEEILRRPITNTFEKKIRPPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7J4</accession>
    <name>A0A9Q0R7J4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7J4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="819" mass="97648" checksum="E061313B6A7D45A2" modified="2023-09-13" version="1">MERINTIKKSNGKHYLKFISENLFEKYDIFARKYIEDRNSKKNIETKVEKIFLQKPQLNSEKESISNEIFSIYRNLIDDTLKTDKLAIPKMEDKYQNNLNDEMQIIIYSTVFDLVEKHYSENKINLANESLDYSAFMIFETAHKYLKNKNIVSPMFNQKQIGKICNIFGLGNYNEPNILFRLFDIDTIIITRISRIIHYSLLYLVGFYSHKNQNKLIIRNDNDKKIQEKIKNQITDSDENFRKLIYNEMESLSNILNISMIDTKLYYSLFLSYISKPENIKSNLNEIEKWKELLKTTFKEKHEDILLQIKQNKQNNNIIEDSILLLNKDPISNLTSKFLKPKEIDEYKKKYQIISFFLENYSKLKILNLFPSFLKFSSIIHSKYSGKHKFETIKFITIKDVLKEINQNYENIEKWKNEFIECWIYSLSEINQETAINFNRKIKYIDEKDKEIEYLTELMKIEEINETTSISKFLPYPENKINIETIIKFVCKLQHDLKQQIKTILFKENIEKEKEKENIKKKKINVLFPFKVDLPNKETNVVDSDFNFGFKEINEHLKFHNINNFDDFENLIKQKLIPSVLTHDIFINVENFQFKDKVIVDTSFFGKIEWGQVEVPTNILNEILDNLKANSQLSFFLFICEDLINLCSDLDSEQKQPDIEQSLSQFIDLNNYNLPQQEISNIFKNNPKLKSIMENLKIKHLRSIYENIQNNLTNIIEQIDPKYNKKPQINHLENFREFIKEIGLTKLLMIFQTFFQKLVSSPQNFEEDDLLRDCLEREAKSKGFNELAKSIKENIQEDIGIKFSVKIYEFCLNYKLNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9C0</accession>
    <name>A0A9Q0R9C0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nck-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEM-1/HEM-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9C0"/>
    <dbReference type="OMA" id="INVWEYT"/>
    <dbReference type="OrthoDB" id="548214at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019137">
        <property type="entry name" value="Nck-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093:SF10">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN HEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09735">
        <property type="entry name" value="Nckap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1185" mass="138488" checksum="CA881D20FB3BA25B" modified="2023-09-13" version="1">MATIPQSLIILLAQKDGLLSQLYNLKMIFDNTESPPFYLESSEVVSVLTKIEKKIEEPITEDTLQIQKLKPIHANLDEILDELEPGIWTLKNIKPFLEESTKVLRHIANEISTLSLESNPNLTKGFMDLFVGYAQLILLLSNFQGRRLFLVLYRLVVYLKTRTDFEDFGPLLILFHKYDNPMKQLYEDLHDFAPAVSPALGSLIPLFTLVSTPDELRKKGVFSITLQENLLQYPIEDNIHFQLPYFSTYTQWIIYGLLFCPQLFESEQFHTLLYLVLANSYIIPIYRDVTFFPHQEFENLFGLNLLKTMKTSKRKQNISTALNNAITKSHQYHRELRAFLRQEINALANFMISRPTLLPLKIHIVLSAIGFCIYEVNWLFRHKRDTPKSKFKVSPDDLKPTDILPLMNIIEKLYNVVSTNTEIIQRYYYKFLIRNDLKALERYYIQFFQERKDKLKDIFEQNLKFIEELSEEKIKNNTSNLDILRLNWFRSECALSFKSFSITEPGLNKLGEFPSRLQKHIERSKMIDIMISQLNLVGGIHTFYPYIQDIYSIVYDTIPSPNLEQENCIIFLKLLNNSHMIISPFYTEELQIIGKKSKHYAKRLFHVISVRITGLVRSIASIKFGFTFLDQQITPVNAALHLINEQMSEQKGANKQELLFPGVESLFNQRKRVEQLQKWQNQFYRLAQVLSFYPTFEIYNKRFSPSKFLIEELENGVKGHLLKLIYEDDERSIIQKPSVFLSIVLNLIYSLKLVEDILNINTLEIVRKVMLKQIYQNNGGARGQIISLREPAILDSSIISEYMTWISSFIQNYITDGVIYSPLRKAFISLPGMLFLSEVYFNIQEMEALCNFFGPYGIRSIDNQILRFIVKDILELKDFVFQNSENIQKFAACYNELDKSWEFIKKITNIEKILDLLIHIGATLQLRELIYEALHKSLKNNASLIYENVELAFTQYPENLLAKEEFIDIDCYAQSCGLLSNSLVDHPFREAIMIANQTGTGIDWGLLPYLFGILFASPTWIFANYLPNIDSHLNNSHCIVKSIKKLLVIPFTVQRKHITKLEEEGEIYLKNQFRKFIEVSSFVILQVDRNKDPKKPVLIRDMFVILDKFIDNSNIFSRDLLDEFIPYTFLRTIYSRFFRETKADQKDEDFAKVSNEPKEEIIENSQPQISQTKSINENEKEIENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAC3</accession>
    <name>A0A9Q0RAC3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgi apparatus membrane protein tvp15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAC3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="162" mass="17993" checksum="BC37528C3CC59C97" modified="2023-09-13" version="1">MPTDKNFLIRIILNISLIAILVTLVVSSIAIMFNESNGQITLDQFFLAFFATVFGLTAIAASLLTKFPYFFLQYGFLKSFVGRGLLVVYASSFAVASGQNYQFLMIIGIIGVYDGIGGIIARSHQPSQYKNDDDDSKYSKISYDVKENDNENDNGIDNENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBR8</accession>
    <name>A0A9Q0RBR8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBR8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="44017" checksum="416F31BE711D5681" modified="2023-09-13" version="1">MNFKETYYYFNTYFNEYEENEPIVIENGSFSIKAGFGGDDAPRAVFPTIVGKPRHYGIMAGMDSKDYYVGDEAISKRGILKLKYPIENGIITNWEDIEHVWHHTFYNELRVSPEEHPLLMTEPPLNPKANREKTTQIIFETFNIPNFYLSNSSVLALLASGRTTGIIIEMGYQVCNSVPIYEGNALNDSVLRMNIGGKDLTDYLQENIKSERGYSFTTTYEREIVKDIKEKLCYEIKDLELLNLYFKPSFIGMSQQGIHEMIYNSIMKCDEEIRKEMFGNIVLSGGTSMFQGIKERIEKEINELSPKDMKIKVISPPERKYSVWIGGSILSSLSIFKNLSISKEEYEEFGNSIIHQKMFLEKEKRKRKNWMFYLNLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC80</accession>
    <name>A0A9Q0RC80_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC80"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029274">
        <property type="entry name" value="DUF4615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15393">
        <property type="entry name" value="DUF4615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="154" mass="18340" checksum="AACD30DD1862933A" modified="2023-09-13" version="1">MKIKIKIKIVENQNENQNENQNQKSISKSKFKIKSSQNEIHKNQNQNQNQNENKNQNQNQNQNQNQNQNQNKNQNQNKNKFKIKIKIKMKTKIKNLKTGKDKPNIEQIEEANKVLRKLKSSKIPIPKKRCIMKDRFGNYEKFMKQTGAYSKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCE4</accession>
    <name>A0A9Q0RCE4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanine nucleotide-binding protein subunit gamma 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCE4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G protein gamma" evidence="1">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="73" mass="8187" checksum="8A4EACF5D23788A2" modified="2023-09-13" version="1">MSEAHLNRKLNEIDRLEKELKQLGSAQKVSAICSSLILYTENIKDPLSPGYDSSKNPWVKEVVKPKSGMCILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCL7</accession>
    <name>A0A9Q0RCL7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo phosphoesterase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCL7"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="357" mass="42342" checksum="E65BE2E4EE1AA323" modified="2023-09-13" version="1">MIIILFGLHNHAFLCQRNLLKNNQQNRLVLISNLEIEPIEKDRETLIQKIKTKFENLFYKQIANNIQKYIKPNNVVFMGNMIKNEEKINIKDAEINAFQRFQDLFFEDLNKKKAIFIPGKNELFPDQLKQNLEENLEEHLEENYEKEMQEYLTEIFKSNFNDFNIRMTKDDHELIFLNSLFLDEEETNRNLESLNFLKSFESQAKARILFSHLPLSKTIGACLDGNNSTLEEKKTVSKVSSFVVLSSILPRFIFSGNSEKYCEFRFGKETLEFVVPSLRKTGQYLIFEYLGSENSLGYDYNILSCGSISFKFFISFWISSIIWFVYVIYSFFTGIHFSEVWKEFQKKKRDSQKRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD07</accession>
    <name>A0A9Q0RD07_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vitelline membrane protein vm26ab-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD07"/>
    <dbReference type="OrthoDB" id="10680467at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="379" mass="44355" checksum="8104C83027148243" modified="2023-09-13" version="1">MNTNFSIETRTLLVRLTFHPQTKFLKQSQTEQITRVEPVEILKRWINFHLGNSQKINNLTSDLQNFKALSVFLKKLTQVDFTLVIFISDVTKKQEKFEECMSKTGYNDFVCSIQDIIDANEEEVVKFLAKLYLWNPNLEDNQSKEDENNDQKQDNQTKIETKSNIESKLPKVSDSVSEILARFQRKSKSPILSKMMKKDEKESNQETQKVEEPKIPDKIQNLISKYPKVEEPKIEEPKIPDKIQNLISKYPKVEEPKIEEPKIPDKIQNLISKYPKKNLKIEEPKIPDKIQNLISKSQKVEEPKIPDKIQNLISKYPKVEEPKIEEPKIPDKIQSLISKYPKVEEPKIEVSKIGDKIQQLISKKEIEKEIKFKIQKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD61</accession>
    <name>A0A9Q0RD61_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 13c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1146"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1146"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1156"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1851" mass="215576" checksum="EBDE475A45D3A3DA" modified="2023-09-13" version="1">MIIYFRQIAEVELTKEKINSNIIIKGARNIKQMLKKKNKKNGDEDKDKIKELGDVKLTDEEMKDLYQAIEYTKLQGIVQDHVPDKYIYFRINLQIQGGDLTLTKTGVKDLLKVSFSLFSALTTIRKKSFDLDLSLSSFEIIDLSPRNKEYPKIISRKRMSSYYFMDENKNNGNRYQSQNNENQSQKYGYQSQNHKNLLEMKLRLNPDHKKSDLDLFFQMQPLQIVFNSSIVKSLVNFFASSQQNYIVDEMQQKTLSQLQSLKDSTNTKIQDVLKNRKTINLQLDIAAPIILIPESVSKENAPLLVVDLGHLTMKSSKSNVNKKINQNSNEVFLLYSQNGRKNLMRESDHYDNYDLELRSANCILLENRSHWDRINSKDEKVIFEGFQVIKNFDILLTTKICVLQSNPNMPALKIIGKLPSLEFHLSKKQYSQIASVLSKTFSDPSEYQTVRRFNEAFDLYMKQLSKEKGHKELIAQTNLETSFKIEKISIFLVKDDNEGFANLSINQIDASYKSRTYDSTLNFKIGGILMENLFDKSCPNFIYSISETRNLIEVTLKNIDKLSPNFKGIDTLIKMNFYKMEVVFQEEFFIELLNFFHLEEEEEKEEKEILSEQVSMQEIAKEKKEESNILTFKSVTTQFMEMEKKPTLLEFIETTADSVEKPKFDFNLFLTLDEKATEIYGAFKNFQIKDLSPYGEKYTSIIALYGSSEPVTFNMKLFNKKESDDSPDIEISTKITGIRIVYLQRFLFEILGFIEDITNKMSPEKPKQIEEQEQEQEQKQEQKQKEQPIFKKKPTIGKDMIWGKLTENRKTLLKKTSHIIDIEFSIIKFDFLLNNFVVILPETSFDDHLFHFEIKEAKITNIYNRELISVSNIYQVKLSQIQLLTGKRKQKTSTYSTVIPWFNINVNVSLPIQNPNSTTIMPIDINGNISTITMIFNRNEYDHLLDTFRGNFKEQPIFFTEPTERGQREQKKNIEQNIRKVTTQVKVHFDEVGVEFIQGIQVLNSDKKTFDAEQLKSFAKFFISDMLSDVKLFTNGDLTVEVFFGSLQGLDTQRNNSSPFVYLIESHTIPEFQSNDHQEDESLQHFSSQERITQVEQNQNHLGVWVDMDWKGNMKIEVNYLDPNFYGLWFPLFQLLNFFTAEPLKEKDSDSKNDENQNNENNENNENNENNENNENNENDDQLIQVESDVFFEKEFNFEKNKSEIQFAQKKQEEPPPPSDFIVIVFIRDLTFLLLENRNNPNTKTVALQQKVAVQYFDNGKGNSKIDLKMKKMEAFIFNYQNPQNRIPIILPFGIDTEMIMDQHKENPKLTDTIINARIDLFNLFSSYQDIITFLTIASDATSFLPEAPKQETDNAIEIAKKKTNTTQTQTSITDYDLHKKIEQQVVEEAFSNLAKKTGYGIKPPKTPQIKEALNLQVSGIRILLINDSLSKQQPLIKLIIPNVNCQAENWSNNLKSQIETSVSVDFFNPQVLSWESVIEPWNFALKFESIPQKNLQKLIFRTFSPLSINISPSLFPVVNEILESMKKETIQDSESNLQKRLSIKIEKSDQKYSEKKTEKQIERYHPLWVENKTGEPMSIKFTRKAQEENAPEIMLNPNQRIPMLQEENELTRREFNQEFPRYVAFSFPNSPSFKSNKVNIEKIGQTLFILDETSNNQNVIFSTIKLEKGCKIVRFHTPISIENHTQFNFDISMLQESQKSFDTKYTIIPDETYTISLNSSSSNGIIFDPSKKSTKTKKHETKFLETSINQKNTIRFTRLKNEINTLFSSVDDSLFFVKSDLKIYRNPSLSRKQKCWNFGIYPYAILENRCPIPIQIVRLIGEQNEAKDQKPQKKRLILLIINNNFNSLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD77</accession>
    <name>A0A9Q0RD77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD77"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="471" mass="54534" checksum="8FFA895A8A5DEE60" modified="2023-09-13" version="1">MNKKRSKPNLENKTKRNRKNISTKKLIFSEEIIEKPNFFYICDLVLPQEIFQSRKAKEEDREQDSQQFLSLWQHAAAVEPDLFFQIVKTITIYRGFNCTECRMIDLVISKFIVKNQVQGIELIKNIGKQMRNGKLEYSQRNAFFAQILSSISTLSNKTEKFLTDLILAISAETVEGDDPLADFLKDCLLQVQENYRCLIINNLLSNQMNSNINENNSNQEFHNEKQFKSMEIEKNSQNSQKNNGNSGKFSDPVLFLFQQIINSEYENNSSQKIMENALPAFLTKFSHLKFTKQQREYLSLGNFLSTQFSNLIHNNFIRFYAKLQIIRGLFTSKFQKETHINNEALVYNEYDCLGILESSFSENRGNLTEIIIPSIFFKVNEESKAFRTKLLSLILANGSNLATVFSTEGSCISFLNTISGRKKFQNHESDEIKSIRKFISKESIQSAWMQNTQPEYDPSRRPQAKISTPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE83</accession>
    <name>A0A9Q0RE83_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE83"/>
    <dbReference type="OrthoDB" id="20080at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF114">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="166"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="645" mass="76520" checksum="D7F7A34BC42B9804" modified="2023-09-13" version="1">MKIKNQNQKPKQIEKKIEKKNENINKNQNQKKIENQNQKKIENQNQIEKKIEKKNENINKNQNQKKIENINKNQNQKKIENQNQNINKNQNQNQKQIEKKIEKKNQNINKNQNQKKIENQNQNINKNQNQIQNQKQNEKKIENKNEKENENENEKEKQKQEKRENTRRKVVQEIYESEKVYVASIHTLIETFLQPLRKLPKLITVDQIKMLFSQIEVIYSYNNLLLTQVEERWKNWDSNQKIGDVFLQIAAFLKTYTEYVRNYNSSINTLILLQKKKDFNRFLKKQESKDGKINTISAFLILPVQRIPRYVLLVKELIKNTSKEHPDYQNLIQAQDKIEEVASYLNEKKREAENINQVLEIQKRVHGLEVILSPSRKFIEEKKMQLVVKNHLVDVVMFIFNDLILIAKQKGSKFELVDSLVLNGEFHFQAKDKTLAVINDVDPKLIIKLTHESNQKPYFFKAKDNEEVGHIVSVLDSLIETFFDQFLSLTPYITQDATKFGTIRLKKVDHSEILKQTFIDNLESSKELRILKLTPKQIYLFDHENINRPSMIYELTECRVRIDVESNGFELKTPTKVHLFSTGSLIDSIKWVNKIRECWMKLFSTFDKSRQKNSSKKYKLKRGTKCADFSYGNTSIFKNNSFIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REQ4</accession>
    <name>A0A9Q0REQ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA mismatch repair protein msh2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_05935</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="13">
        <location>
            <begin position="985"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="818"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1442"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="818"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="858"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1444"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1461"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1483"/>
            <end position="1492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5077412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1492" mass="172987" checksum="4B09ED89227209D3" modified="2023-09-13" version="1">MTNTQNTIPGVETSFIQFFQKLPTTKKDEIRFFERKSDGKFYTCHGNDAKFIAEEYYRTLATLKYLGPQNNQLPSLSLSQQMFDSVIRDLLLIKRYRVEVWGTAKNEDDLETQKTKKAKNIKKKTQPIKTQRGKNWVVIKKGSPGNVRDFKDVLFGADGEIEYIDASPIVMGIKIGKEEGERVLGIAFCDTTLHSLAVCELKDDEQFSTFESLCVQIGAKECLLLSMDSANKEQKSDLKKIHEILRKNQIVLTEQQKQLFSVKNIQQDLSRLVGNLANHLQEMMKKNAIAATACLIKYLDLLANDANFAMYSFRSFDPKNFMRLDSAAVEALNLFPSKKDHIDTRVSFNYSSYLNQSNSTQSKLNTQNNSTDNENENQTESNSIPKSLLSISNLNRYSNLAGLLNDCKTKMGSRKLFLWIKQPLINKEEIERRHNFVEIFFEDTHTRFKLQTFLKKIPDINRITKKFQRGSAKLQDIVQLYDATQTLKQIYNTLQEYDADENALDDSDDFNMDSFKFDKGEEKTIKKSNVHILEDEQLDAHIPSKISSKQKQLVREVYTQPISQIISDLSNFEEMVESIIDLSQAEKHKFLIKSHFDPELDKMNKKKEKIKEKIERIEKKVNSHFSKSNIKVKFESNDQIGFYFRISRKDEKEIRNSKKWKPLETRRDGIRFSTQKLIDLNRKNQEIEEKYNQLQTELVSHVIEVALSYVSIFEVVAETISELDVIISFASVACNAPTPFIRPVMYDSTHGVLRLKDSRHPCLEMQDEVNFIPNDIDMEKNKSSFIIITGPNMFGKCIVGDSLVFTEKGIFEIQDLNPNLNQNSNPNLNQKNSKNLNQKNSKNLNQKNQNYGFHSFPNQKNSKNSKNSKNQKNQNCSKFSIKTRFGLKKPSHFFFGKFKKCLTIITKRGFQISGTKNHKLLVSNQNNFFYKKFSHLSQNENVIINYGMNLWSSKKLIKLENPHSQKINENNIIYPTSLTQELSFLLGIIIGNDSIIKSDSITFNSKNPNKSKKLLRFLFKKIFNFQNINFFNQFNSKFSIKLHKDLIQFFKTNFEFNLNQKSKEIPKKILRSSFVLIVSFLSGFFFLFNNQKNLSTKKQDSKMIINSSKLSQQIQLLLLNFGIISSRKEISSKENDSIYYELEIEKERKYQDIFENLFDFDFNFNFNFNFDFDFDFEFDFEGISKKKQKYMEKLIEKGKQSGGFYLEEEIKKIEKETNEKKQVYDLAMEKEHSYIANGFVSHNSTFIKQVGVIVLMAQIGSFVPCSLAEISIRDCILARVGAGDRQLQGVSTFFAEMLESSSILKTATRDSLIIIDELGRGTSTVDGFALAWSISEYICKEIGAFTLFATHFHELTVLDKHLSMVANFHVSSFTSQNNITPLYKIKNGPSDQSLGIRVAEITRFPQSVIDEAKRKHKELESKKKPFEYKFLLDKEEIEKKDLEMEIENENENENENQIENENQKENENQKENENQNENQNQNSIKSSKPNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF53</accession>
    <name>A0A9Q0RF53_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF53"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="218" mass="25038" checksum="02FC4AFB2234C86A" modified="2023-09-13" version="1">MCWSLESSLIMGLWSVIVSLYAIFRNASYRDRWQGPFILTSCLMQFVDTILWYDHSVNGLETCSNLNYYTSKYLLLWILSAELLVAVFAPGIVANFMKKYYYIPNILGAIRVSFTSEGCSSLSPQGHLLWFGVNIKTFYSSLFLIGVVWPCLFMKPFIAGLSYIAFISGVWLYSTLYTDAFGSNWCFLSAFTAILLLFDPFLFGRFFPEKKVEQKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFT0</accession>
    <name>A0A9Q0RFT0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tbc1 domain family member 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFT0"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="36"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="292" mass="34236" checksum="E8A05F47885B9866" modified="2023-09-13" version="1">MQKSRLARRNEQFSSAIKQIPIDMSLIKALAFTGIPDSSNLRPIFWKILLNYLPLNPKEWEDTLKENRENFHILKKEVMIFPFDLSFNIVNLISEIEDAMEEVKDSKLNQEENEKKKKMIAEKQLQLEILKDVSRTRTSMSFFHLHEEPEVDEKVLQKLKTNSEEEKKINENENENQNQNQNQNENQNENQNENENENQNQNQNQNENQNENQNLNQNENQNLNENNINLQSNTESQIKPKKPNWVLSLCNILFVFAKLSPGIGYVQGMNEILAPILYIFATDSDPESQSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFW6</accession>
    <name>A0A9Q0RFW6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFW6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="333" mass="37900" checksum="91EA6418E8397563" modified="2023-09-13" version="1">MAEQIIIIDNGSQTLKVGYAGDDAPYKILPTIIGKPKNKELIQMFGGKEYYIGDSAKAKSGILNLNYPIKHGIITNWDDMERIWYDAFYNELRIIPEEDSFLFTESPLNPKENREKTTEIMFESFDVHSFYLANSAMLAMYQSGKKTGIIVEIGDDFSSVVPIYDGFCLPDSIMKSNLAGREITNYLIQNLNQKGIEFKTTYEKDMIEDLKKKTCYKLLFKPSLIGIETQGIHQMICNSLNKISVGIRKELYQNIILSGGSSLFPGLTERIQKEVSQLLPLKIKIQIISPPERWLSTWIGASILASTSNFAKMWITKEDYQENGPKIVHQKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGB8</accession>
    <name>A0A9Q0RGB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000021">
        <property type="protein sequence ID" value="KAJ5079916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGB8"/>
    <dbReference type="OrthoDB" id="10249208at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="253" mass="28366" checksum="51FECC134FB3B441" modified="2023-09-13" version="1">MFETFNTPAMYVAIQAVLSLYASGRTTGMVVDTGDGVSHTVPIYEGYALPHAIMRIDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFDQEMDVAAESSSIEKNYELPDGQVITIGNERFRCPEVLFQPSFIGMEQPGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTSMFPGISDRLQKEITQLAPPAMKVKIIAPPERKYSVWIGGSILASLSTFQNMWISKEEYEESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGG9</accession>
    <name>A0A9Q0RGG9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein rab-11c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGG9"/>
    <dbReference type="OMA" id="LEIINMM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5079212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="225" mass="25606" checksum="7620A6A85A520A07" modified="2023-09-13" version="1">MQETKQNEDTYDFLYKIVLVGDSGVGKSNLLTRFCRNEFTLAGKTTVGVEFATKSVQIDGKTIKSQIWDTAGQERFLAITTAYYHGAVGALLIYDLANESTFESLDKWLEEIHEQAEKGIVIMLVGNKLDLEEKRVIPTEKGKKLAQEHNLAFIETSALDSTNVELAFQTLVSQIYEMKKKSNNSHPDQEKYSNQNQETIDLQNNSIFIQDSKDQRNHNRKKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGI8</accession>
    <name>A0A9Q0RGI8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGI8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="288"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="396" mass="45575" checksum="98EA101678DF50F1" modified="2023-09-13" version="1">MWKKSNIFYHKQLSTLQLPLLCANNVQRVFSGLSSEFFYFQDLNGQLFSCGLNLQGQLSLNHQKNISIPNKIITENNPKFPIGAILKIATGQNHSFLLAQRKTTSSNPENFVYFVGSNQKLIFSVVDFLVNKNITDISSSSTHSLAITSQNDVYIWKAGEPIDKFHEMVIDPNISFENHSIKVVCGEDTSFVFSLVSKSLISDFQNLLERKEFTDIEIPTNSQKIPAHRLIIELRIGKENVSKLIQISYSKSTFEPRTLGFDENWVANKSGKKGLIRDLERLYSDEDSKDFIIIAQEKIKVHRLILIARSDLYRGMFLNVNDSSNCVNDYSGRSAHSIKQVIQFLYLNKIDEDLSVEIVDELFDASEYYQLNDLLYFNLIIDKIRQKQIREKKREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGJ2</accession>
    <name>A0A9Q0RGJ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGJ2"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="71072" checksum="2232D1EB85FF4630" modified="2023-09-13" version="1">MSTKQETLIENDSENVNNSNNEMEVDKKKEKDLYKQYSLYPKKRVTKTQKIIKKAPKLRKSITPGTVLILLTGKNKGKRVVFLKQLPSGLLLVTGPYSINGILLSRANQRYVIATKTKINIENVKIPEEVNDDLFKQKKEKVEKEKSEKDLLDGEVGKKKKKEKKVIPQEKLDRQKIIDEPILEEIKKEPLLERYLKSLFSLTNGQFPHKMVSKFQIQILSKQKQNKKKMMNSQMQIMVEDESKMDTQEEIDSVMNLLQEVVIKFYENETLENKNYIWLKKYKVQLLKSQKKQRKQKLIKMDSVLNDIQKQILQIKLEKEKVIEEAKDILKEYSLNLRNTNENSIQKSKLQHQLELNQNQNQFKNENENQNENENQNQNQNENLKENQNENENINQNQNENQNQNQNENENENQNQNQIENENQNQNQNQNENINQNENENQFKNQNENQNQNENQNQNKNRNQNQNKNKNQFKNQNENENQFKNENENENKNKIKNSNNDVSVESLLTKVSDLVQENFSLREEIRQKDEWITQTKKFNEENNDSKNPINLKEIIKHKKEKIHQLKEKISIYQQYLSDFQLDFDENQKLLLFQGIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGU4</accession>
    <name>A0A9Q0RGU4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_05362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGU4"/>
    <dbReference type="OMA" id="SHAFFGQ"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="129"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="232" mass="27549" checksum="51E70D65CB9BC340" modified="2023-09-13" version="1">MSSKSKRDSKKNTKKTRKTKPKKKDELERPRKPRNPYLIFAAEQRETLLKDNKGLKVGELSQKISQMWKEVSEKKKKDYQKKAEEEKENYKKELEEFEKKRIDMDESVKGKDEKKKRLKFRQLLDLEPPKRPKNAYLLYAQEARSKLMKDNKGIKVGEMSKQIAEQWKALTESEKKKYQEEALKKKEEYKEAMNEFNKKRLAMLTDSSDSEDIDKFFKSSEESESESESGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHF9</accession>
    <name>A0A9Q0RHF9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHF9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="68644" checksum="908F7589AE768906" modified="2023-09-13" version="1">MNDCLFFGQNEYPILIKNEPNKITKPIQFKFENENENENENENQIKQISSSSFSTIFLFKNGKAIEYLHDSNQNPSKIQIEENIQKVTVGSGNEAILTKEGNVFAKGYDINSNNPKEFINISSLIEDTNDRIIQDIVSGRNSIYLLTSNQNAYGIGSNRYDQLGFDSETLKKTEKPILMMKNVSKIFSGNYSNHVFLLNSNQELFGCGDNQFGQLGLGESRKEAYIRNLTKIQNIPKGKIIGIQCGYSHSIMLIEDEDENQNPKRKLYSCGDHKFNGLGKDENIYEFTEIKSSLFENDDNILDFSVGYAHTLILTSNSKLIVFGSNYSGQLGTGDYSYTSIPFQTELPELRFNEDVSNYHVSCGGFSSFIYYSPPSFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLNQNQENQIDKLQEIISKKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQTGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHN7</accession>
    <name>A0A9Q0RHN7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000017">
        <property type="protein sequence ID" value="KAJ5080008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHN7"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="334"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="794" mass="95434" checksum="A9F48BE6A30CE875" modified="2023-09-13" version="1">MVKWGNLYVYADSPLISKHVFFDILKPYKIVRGYLRRNKDSTDGHFKVIYDKKARKEQRRTWREGYSITVSKARESYTSKENQLEKLKEKITDRNQRSHKENIEKIIYQTLNSNNFIKNPLIIKKKEIENIQSNQEKHENILNEIKETIQKAIPQMKSKRIIQKDLQEFINKSVNYSYLKTYKQHNPYSYQRTHNLQQEISDSLIKHNWEIDTNLRKTINYRNSKYYMETNFNKILQILDSYKLIIRKSFLNIFEILNIINNFHPLRIIQKGNHQAEIWDRKNNILNLFRDCKNERNRIPRNFKIQLKTTEGNKIETIKGTKLTKINQFSFRIASININGLNKIGKIQKLEKIFLQQRITIAIIQETHLRKRLYFENYHSFEKQGYGTTAQGGIAIIIKKCISKYAQEIKHPDKDIIQIKIGELNIIGVYMRHGTQSQMMSQLNDIIEKLGEERYIIAGDFNQTDKEMEKHFRFNTQIIHNTENSAIRNIDHFCVKNQNREILSQTVNINQEENLSDHKMIVTIEKINILSEERKEYYQPTKQQFQDMIIEKLRKQNLSEKSMLNISIIKNVKEKFKKRSIIHINTKNKIGINLTEFNSKNKYNWKQALRKRWRETMRGIEIDNQSKTNYWKEVKRITKARKDTIFNNNEKEKEFKQLIDKIKIPVQESILQEIENKIINTEPDIRSIKQIFPHDKLIKTIQNSRNSSTCDYDKIEMYQNPYIEREHPKYYEFIKSVNRMMREWIRDPNQEVIKYMLSRRMVFIFKQGDPNQISNYRPISINNAFSKNIFEKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RIJ9</accession>
    <name>A0A9Q0RIJ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bridging integrator 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RIJ9"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="456" mass="52008" checksum="DB3283234A9D0E57" modified="2023-09-13" version="1">MDGLFAKFKRGQQKLREKFGSAERSADARFDEIYQKYKKLGDECKNAYKFMISTRDTLKAYITESTKVSNSILGIYDASNSKMRFPAMKFANSQNKCEGDMMKIFEERINTLAIERVGLIIGVFVKWDQKIKIRERRLTDVDVLKNDVHKLTENPPKDPIKLPRAQQQLKEAQEAYELINDECIMAMNAILNQRDKGLDVPIAVFLSTLGGFFIEYSRQNTELLGSIPSMDVNDWTNLSEMTDEQMKQIYHKLYPQETKKRTAMGKGKVGLAAKKVREPKRKPKGKTKGKAKGKTTGKTKGKPKGKVKGKTKGKPKGKVKNSRSFTSSSSRSRSRSRSISRSISRSISRSRSRSRSISRSRSISKSRSYSKSRSYSFSPSRSYSHSGDERKSPNHRSKNIQTNSKPRSKPNSRPNSKPRSNSKTKDLIQIQIQIQIQIQIQIVLLFVLLENLILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4S6</accession>
    <name>A0A9Q0L4S6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Enolase-phosphatase e1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_03470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4S6"/>
    <dbReference type="OMA" id="EAPRHRH"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000002">
        <property type="entry name" value="LIM domain and actin-binding 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="17400" checksum="FC0BD272268B1A16" modified="2023-09-13" version="1">MSEKCAVCGKTVYLMERLNVDGTTFHKKCFKCKHCGKRLTASDYRAINQQYYCGAHFKQIFLSTGHYDAFKNETANLSTPRSNKPLTRPEVKEEVKEEVKEEILEEPQDEIQDEIQDEMQDEVQDEVQDEVQDEIQDEDQNEDQDYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5Z9</accession>
    <name>A0A9Q0L5Z9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000143">
        <property type="protein sequence ID" value="KAJ5066430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5Z9"/>
    <dbReference type="OMA" id="MITVFRE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="563" mass="65127" checksum="73D347155BDB9E72" modified="2023-09-13" version="1">MDYTPTDKELKAIFRRTVQFAKERGELVYPQINFAMKDPIPTSVPNGTKKKEKEVETEMSFSKEDSRPMITVFREESRPQRQRRFTTAAKAAPQPPPKPNPQTPLRQQSPKQNLSQSSPVMVSQNRSARSHTQYTKPPQTQPNQQPRFNSQFTPNKTQNSLAKNQSNLDKSQESKSPFNSRQSQNQSQTRTTYTSRQNQNQNKSPNQSQTQSQTQTRTTYTSRQNQNQNQNKSPNQSQSQTRTTYTSRQNQNQNQNKSPNQSQTQSQTRTTYTSRQNQNQNQNKSPNQSQNQTQTRTTYTSRQNQNQNQNKSPNQSQTQTQTQTQTKSPYISRQNQSQAQRKSPIQKQETKPNETKSPINSRQNQSQTQSQKQETKPNETKPNETKSNETKSPINSRQSQTQSQSQRKSPIQKQETKSNETKSPINSRQSQTQTQRKSPIQKQETKPNETKSPINSRQNQTQSQRKSPIQKQETKPINSGHSYHHYSSRTSHTHSPSKSQTHSTSSRYHHSSNSNQSTNLDDKQLISQLRKRISELEYENEVLKKENDKLRNENDKLKSSNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L623</accession>
    <name>A0A9Q0L623_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L623"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="309"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="475"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="602" mass="70305" checksum="746B97F5A71678C3" modified="2023-09-13" version="1">MNEIIFFGENEFLKLIKNKPNKITKPIQFKFENENENENENEKQIKQISSGYFSTIFLFKNGKAIEYLTENDLNQNPEKIQIEENIQKVTVGWQNEAILTKEGNVFAKGSYIDPKNPNEFINISSLIEDKNDRIIEDIVCGWCSIYLLTSNQNAYGIGSNESSQIGIKIPKYVKKPILMMKNVSKIFSGNASIFVFLLNSNQQLFGCGQFDLGKDEIKFNKLTKIQNIPKGKIIDIQSGYFHSIMLIEDENQKRKLYSCGDYEYNGLDKKFGQSTKEFTEIKSSLFENDDNILEISVGHNHTLILTSKGKIISFGNNDFGQLGTGDTEYQSIPIQIELPKLRFNEDISNYHISCGAYKSFLYYSPLSFSNLEEDLIKLFERKEFCNISFKTKNGEVIEAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETIKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITQEIIDEIQTGIDYFQLNQTNPNLFDLLINKFNNQNQNQINNQNQNENKKEKENCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L633</accession>
    <name>A0A9Q0L633_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L633"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="170" mass="20272" checksum="80686E01C2A309EF" modified="2023-09-13" version="1">MKQIETSIIWKYKNPNYGLHLFFIKNYILKQLEDSRTLNDYSIQKESTIHLVFKIKRKGRISSEQQRLIFAGKQLEDSRTLNDYSIQKDSNNNHLVLRLRGGNFQIFVKTLTGRTITLMLIQMILLRILNQKFKKKKEFHLNNKINFCRKQLEDSRTLNDYSVQKDSTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L685</accession>
    <name>A0A9Q0L685_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_13252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L685"/>
    <dbReference type="OMA" id="YNTRIPK"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11367">
        <property type="entry name" value="RNase_PH_RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="191"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="289" mass="32327" checksum="264CC60CD9EEDDB8" modified="2023-09-13" version="1">MDRLSFSEQCFIIQGIKDNIRNDARTRLDYRYFSIETGILPQTNGSSRLRLAGTEIVVGIKTEIGEPLKESPNDGRIEVSVECTFSTSERRSKEVLNQEITAMMQKIYSGGKAIDLTNLSILKEKKCWILYIDVLVLRSDGNLFDGVSLAIKAALFNTRIPKVQVVPGERSGEIEIEVFDEQQSEKINIKNVPICVTISQVSGFVVIDTTVYEELCIDSSLVVAIDSSSNLFGIRKYGNDGIESSSLIEIINLASKAGQNLHARLDSLLQFEEKNRIQNSLDLDFIHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6T3</accession>
    <name>A0A9Q0L6T3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ciliary rootlet coiled-coil rootletin family member 2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6T3"/>
    <dbReference type="OMA" id="KSFSACH"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="384"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="567" mass="66725" checksum="B07D141A8AEE95C8" modified="2023-09-13" version="1">MTETKLIDAQVKSENYRNQNEQLREQLSQLSNSNTSNENQKDNGQTVILRSKVTELENSIKSLQNQNSLLETNIKEMDQQINKKDLDLKEQKKVENKLNEQLKIFSDLNNQVKVQVQEIEDTMTQKTQEMSSRINEKEDEMQSLESKVQKLQSMISQKDSEIEKYISQIKNSNEEIQEKSKQIDDLNESRLQTEKEQHNSWKSFVEKIQQIFSKSTIPCEIDFSYLSVGNEDESNEKQKTSKLSQLLKDIYAFLETKIFPKLEELNEILLELEDSKETKLEESQQATKIDQEVQVAPFEIDIDLIKKFSLSKDEDEQQEILCDHIKELEQSLQFKSEEFESLKKEHHELCNTLVDQMDDETHQLIKDVLYHFKDQEICELNDTLHEKDEEINDLTEQYSKVLSRNRELAVRVKKLEQRLENQKVTKNQPNNSQREMSSIIPFKNIKNVQNIQNIQNVQNEIPKKKNPQNQIFKPKTLRFTKFGSIGLGLKRTTNLGQPMRIKRTISESENERDNKKEQKPQKEDDDENISFSENIPKRSHSDNNDKLFKEESNDLSLFDSKRTKIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L799</accession>
    <name>A0A9Q0L799_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-10-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L799"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000002">
        <property type="entry name" value="Muscle actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="378" mass="43264" checksum="01020333E703BF0F" modified="2023-09-13" version="1">MSDDDDEILAIVIDNGSDTIKAGFSGDDKPRSIISTIIGKTRNSGEKLEKLEKEYYIGEEAKTKREILQLKYPIEHGIITNWDEMEKIWNYIFYKELRIAPEEHAVFLTEKIMNPKANREKITEIMFETFAVPAMYLSNTSVLSIYSSGRTTGISVDLGDSEFNIVTVYDGYAMSHSSIQSSVSGRNLTDYMMKILNERGYSFKTSEEREIARDIKEKLCYVALDFEKESDSSNRSSSIKKEYYFPDNTNSITLEDERFKCPEPIFNPSLLGFEHPGIPQTIHDSVLKFDHSFSQCYSENIVLSGGSSFFPGIEKRIEKELIHLYPSVRFKVIADPERKYYAWIGGSILSTLSTFQSMLISKEEYDETGPSIVHEKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7X0</accession>
    <name>A0A9Q0L7X0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pote ankyrin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5067987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7X0"/>
    <dbReference type="OMA" id="HLVCQKD"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44207:SF2">
        <property type="entry name" value="REPEAT PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44207">
        <property type="entry name" value="SURFACE ANTIGEN BSPA-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="549"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="616"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="650"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="779"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="901"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1027" mass="118641" checksum="C6A3EA22E588A1FC" modified="2023-09-13" version="1">MNEIYQSIKKNDIEYVNKINFSNTKLENNEENKDFLHFAIKKNSTFEMIKLLIEKGINPNSNDKFRNNSLHLAFLNNSSFEIIKLLIDKGVDVNAKNKDNETPLHLACKKIQNLSFEIINYLIEKGADIHAKTDKNETVLHLVCGVNPKEVEEYLIENEESSVIQLDKKIAQVIKLLVEKGIDINSKTKGSKTALQLIFKKENLSTNKNETFLHLVCQKDNISLEIMEYLVEKGVDINAKTKGSKTALQIIFKKENLSFEIIKFMIENGADIEQRTNKNETFLHLVCQKDNISLEIMEYLVEKGVDINAKTNDRETALYFVLAKQNLSPEIIKFFIEYGVDINENIKYDQTALHFICKEFHSTEIIELLIENGADINKVDSRFQTPFYIASKYNSSLEVIKYLVGKEADLHSKGKYNEKMPIHLACKNNTLEIVKYLVENGADINKKAIRNQTPLFFACHRTSFDVAKLINKDTNNLDKITKKNGEVINEKTDNESLEVIKYLIGKGADINAKTTINETLLHFACIHSSFGVIKYLVEKGIDVNSKTDQNESVLHYACYRNTFEVIKYLISQGADISTKTNRNETPLHFACHKNSLEIVKYLVEKGIDINAKTNDENESALHIACRKNSLVVIQYLVEQGMDIDAKTKPKDETALLIACRKNSLEVIQYLVSKGANIHAKTKTNETVLHIVSYVNSSESLRFLIEQGLDIDEKDSKEETPLSIAIRNQNHYSTKLLLMNDANFFDLKENEMLNENYELITKIYSINEDMNNLLQSNQLSDLTIKSNDSFQFQVHKLILLTRFDNNESILQKFINNCYQKPKKEVEIALNFLYTGFVDFDDFNISLAQKIAKINKEKLLLLSFLGELLESQIGIDSNWIELKKGRRNLIKDLSKLYEENETKDFTIICENEKEIKVHKLILILRSELFKGMFLNVQDSSNQVHDYSEKSFETIQQLIYFFYHDEFEESKINHKIIEELKDAKDYYQLNDKSLLDSFLSDILLKSSKKKKKWNERMRFMNKKNSDCKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Y2</accession>
    <name>A0A9Q0L8Y2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sesquipedalian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8Y2"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="727"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="882" mass="103629" checksum="CF27235BA8B2EC94" modified="2023-09-13" version="1">MNQNVLKDQKIQNLFQSLFQKFDSKKIEYEDKKAKISNLKIIPEIAIKLTKKLNIPLNFIIEKIKIIDMSSTEQRPNQVQTKEMKITIKIDDQQKIQNLYQQAQKSKHFKKDFSISILETINFKFEKLTILFRRNENTIFSLIFTQPSIMYSTSRISEIQQFQFPEISEKNQNQNQNQNQNQKFDGNSLIISCSKIIAKGFLSDLVSKTKKVGQSIEIISDSTQIGVSFSYRDGIEIMTSHDKIELSQIGFAMLFAIFSKQFEQNPNKKEKKKQRIRLDSIIQIFGINLKKENQNQIENQNQNQNQNQNQNQNQNQNQNQNQNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNILVENDTEFEQNNSLSNLNTLEMKQMLIKFDSNSEETMKIGAQLLNFAFPEKEMKEGVLQSKNENNDQFCEVTISKKENDEIYIKSRFDGLLFSGDFPGLNFITHSILRMSKYFKIFYRFFLNSDLIPKVERETKFSKLELFFASEDFDEEKEFDVSRLTEDAEDFDETQSDDDFSKSKETNKYFSVDLLRIKENEKNSTHPMIEAENIRFSMQENNLMLHQKEYFVSSIEKDTVLQLNKEYNEKKDKFTINGFTLKSPNFSLQLPIDLVMCYQKLHTFFVEFPSKSKEKDKKSHPKKTETVENRDSFDISTVIRQAPNSELANLLKITSEMEQAYHQVSNLGFVVERIGSIFEKNTRRMFDYTIPTTKNVYKAGFLEKRGHKVKSWRKRWFILSNDTLRYYKAKQPIDETKHTELPLGIVPLDKSIVSFPEKEVIFNRKWCFIISSPNKIFFIECPNRNVRDDWFSSLSSVIQMLQIEKKHGLERDLTESSETEESKRNNLFDSSLEICSQLQKQIENIENLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L964</accession>
    <name>A0A9Q0L964_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol n-acetylglucosaminyltransferase subunit c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L964"/>
    <dbReference type="OMA" id="STSYHAF"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="338" mass="39198" checksum="6E1376B441723DEC" modified="2023-09-13" version="1">MDSLNHSQNNNSNDEKEDQNNLITEKPKEKTNKENTIEKSNNNKEKKEKQAREPFRKILYLKQDYPDNYIDDSFLEKLILNANVHPLKFWEVSKSSLAITQQVTIVIIFCLVFFHALTNTITITHFFILDIFLVLIGYFIFLLILPIKTISINKFLHHLKVLLVLLVLLYCVSPVLRTLTQTFSPDTIWALTIILFVIHLLSQDYDYINGLSDKLNAPLSLNAAIFASVILASRLDSDMLVFAFVSFAIEIFGFFPVIRHMAYKLSFKIHFLLTFLMCFGTFVSIYVFNRFFSFLFVGVLLMMSVFIPGIFTYLHRYKITVNGPWDEAKPAPLYSLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9D8</accession>
    <name>A0A9Q0L9D8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein sey1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9D8"/>
    <dbReference type="OrthoDB" id="2343366at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="239"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="420" mass="48626" checksum="F631350DBFA17919" modified="2023-09-13" version="1">MSEVTKKEQNQEKENDYCGYKCKSCGYFCSLPKGHPGLHFCRHGNMKDGIIVTEKEQDAIQFNKINLRTGESAKSFICTHQCILFGRGHIHLIPVNDINFNDIPEEDRNYIRLAQNQYSDNVQYYEATCYFYWQHYLKFESGFSNEEKFEFSRCGAKCRSKFMKQKKIMQKITTNKPKNIDKNLSKRGARHPPYCVLPMWHKPWDPNEIPDGQAQGYTSTDGHFFPCNHPNTGIFANYHHYLIIDRSGSMGSKDVKPSVYDWIYECKTTKKIDALLLLLMSKVDTIFQSQIVDSNLIERYCRNIKPRGGTSFKVAFERGFNLLNNLDDRERQIRPVFVLLTDGEDWEPQQTMNLLQQNIPNFPDLIIHTIGFGSDVGNSPQFLKQIANLGNGDFHLAKDNIELAEVFKIIAKEPAKDRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9J2</accession>
    <name>A0A9Q0L9J2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 6 regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9J2"/>
    <dbReference type="OMA" id="DNQMHQE"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="748" mass="87990" checksum="93CE6B672769B514" modified="2023-09-13" version="1">MFLRFGFTPSKIDKILNKENFTLEDLFAEETFLQECRNKNRKLVKFLSQKPIVEKILIYLLQPPNEEESKNPLRKINYPYYAHQIMGYEIREIFQTIADNPDLLENIFKFVNTETGQNPVYSSHFATTFIALLSNIPERTIEFMEANMKIVENLTALIGNSSICDCLIALISLNFEEKSTFVEELKKIGFVESLIERIGPKFSPVIQDNTLNFLLELFELYPQSTFIPLSEQLKTEEMINKIVDQIFSENRTTSSLEKGLTLIIEFLLHLHPVIEPPVPPIVSIILDRLEDFHKLLIHDSITPNFSITISGNEQKPLGHTRLKITEFFNILTRIHYPKLENKMCDLNILSILLDLVFEYKWNNFLHNQIKSIVMTIIDNGNEIYINNLFKEAKLLDRILREFSFAIENNSKENTILNLKNKSNQAGYLGHFVDISNLITHKKISNDKLMGFLEENEKWTEFEKGYLNEINQLQNKELGNEFSSFTSNISDFRAEQQFLDNFDVDDDDDDDGIGSDDDDDDDFGFGDGFDDFDDANDSFDLEFTGKDDFDLEENDEKKYPNFENEQENKKDEQIKEIKDNQMHQEIKDNQEIKDNQEIKDNKEIQEIKENQDNQDNKDNQDIKDNQMHQEIKDNQMHQEIKDNQEIKDNQDIKDNQMHQENQDNQEIKDNQDNQDNKDNQDNQMHQEIQDNQEIKEIKDNQENQDNQDNKDNQDNQDNQDNQDNQDNKDNKDNQDNQENQEIKDNQDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA10</accession>
    <name>A0A9Q0LA10_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA10"/>
    <dbReference type="OMA" id="HFHLLNY"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="237"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="449" mass="53441" checksum="2EE0CCE20381A705" modified="2023-09-13" version="1">MNKENQENQENQENQTNENNFLAENSQFLDIHLIFPLLEFILKEKLRPENEIFQTMLELAQQTNLFDIEFRAFRKLNNTNDIPKEMLDRKDQVEQKEKLLFQKIKVFIDLINGSLEDKIPDLLSQNSLTMEFLKEKYKIENQTLNLLFEYSRLIYDKGEYEKAIKTLELYIILENKSDKQLEGLWGKLVCEISTQKMEEGEKTIQSIREIIEKTLPKSNQRYQLKCAGFLMHWSLFVFFNSPNGLNQLIDLFFNDLYNSVIQTFAPHLLRYLCVAVFLDQQRRSSMRNLLRLIDQEKYRYSDPITELIYSTFSKKNLNNIESQIEKCEKFCTQDFFLFGIKDQFISSIRVSIFEIFCKIYHELSFDVFVKQLRINPDDVENWIVNVIRNSNINAKVDSENRKIIIQQHFMNVLQNINYKIKNVPQKLSNINLAIQEIEAKQNPVIPQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA78</accession>
    <name>A0A9Q0LA78_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19599at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="1921"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="2274"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1433"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2481"/>
            <end position="2509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1124"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1445"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2589" mass="305465" checksum="0528B0A0CD1A7332" modified="2023-09-13" version="1">MSIQIILLILTSKKSKELKIGIAKENSIQQQKSFIPINKSQENENLWIYETNTLQKTQEFLLIELPESYFNFFTNPKKEKITEEIKPKMTTEINENNFTDIFLTKDSVFAIPFNQIKKFASSIFVNPFRPAAISEFFPYLFVNVFDSQGKILQNISDKNNQVQILLYLFHQTSVFIKQFNNQDIDLQSIMFFCQIIISLALLSYFDFDFFLIEKLLSSENRIKLFTFVNQLQVISIPEIIQRIRISFELYFQKIHNQDPKERKSRFKFLYQCLPFLTICLNGDNILTYILTEYKCISEMEKEKEFLDVLKIVTEKNYREILTTDFMMYIFYQSNINRKNFLFLLFKHKIFGYFNDEIVKLLMKDIDNFPHKTLSDRFLYWDRILDETSKQKMETKKLIKNYIQKQILDQNQLSKIDHTQFIDEVASKKTLEGLHTSYFYDYFLELVKKSYRYSNQTKRRERKIIQNILFDDIQCSYWESLIKLPKFKSTERSEIQKFFHFISNLEKKKRSDLRNEIRWIRAARRYFDIHKAQSGSFPKNAYFLYKIIYNLEKDIKSERCCPPEYKVYHDNSKFLTQIFKIIDPKFTDSNLKPAFRELQKKILILHNFCKSDIIKASIDTSIYETISYKINTGKLNVYDSLKLISFISEEEFKFFNVITKIQPSIIFRTLVWDKLITTESLFTKSKKRQKKPRLFHDFIKILLQKVASFWTKTFQLFYEGNIEFFNLDRFFKKDCNNSYVKQEVSYLNSQYPIQEKEIDPQKIFQFIDIRRFRDQIPNFIGFCSNFHFQNRDSFNRLRNLSELEDSDFAQKKLKDSDLIYKDISNTLAKLKPDTFNFLSELVPGLNGNYDKKLFKFLKKYPDLIQLKRDTDPTKFDDNVMAEVSNSLIRVHTRVSSYFFKDNLSDLSQLCDFIAKAEEDVTEEQKKVQLNFIHSRIEDIESLISSQKESPQEKAMNTIKAIFDPDTRFYFTINDKGAVDCYLHAFIGENRKIAKFGLGNLVEFNSTVLSIKQQQNQTNKVFSKFTRTLPKISAAISAFSRLASSGHFEFSMGYQKELKLGSHSTQWKKEFEEAKKEFIEALNQWEKDKNEIFFKQKEFKFLSFFSIEQLKLISDFVNLKKEEHINQNQNENQNNENQNQNNNEKEKEKKIQSETESESDDEVDSETDTYSEIDDEEENNLKKKQEIINILHIFSPKSENIIQNFEDFLQKYEKDSNKFNQNEKNKQEVLKYFLKQLNLGVLEKLFSFEDLKQEGEFNIEEEPFLTFTSKMRKYFNQRDGTIGDPKIFIVEIPNSYRIYDMTTSFFLIHTKSFPKRENVLCCNQKTTEDDISIFFSRYQMFHNYVKDSEKNFCFAILFANELSKKKQSHLIFKIQSIDFKTKYPMILLCTGLINSFQLLASCVYNGIIRDLEPLPPESIRNIYLQEEYQDDLNNEIDENNENNENNENNENDVNSGDDDGDGDDDGEGDDDGDGEDNGDGDGDDDGEDEELNFQVYVSEIAGNGKTYQIQKTAFEKYPKHLYFRLLIRSNKIEDLISQLKTIPRNTKNFIHLDFAHCINLEMSKALWSLIMFDHIEDPRCYGGNSAFILQKTDLIYFEIPSIRLKNSNFGLDIFPVLKYLPVVKCETNQNTISSLHLEKIPENGEQIPKFIENKYIKLIANFFLLKKQKFQNIHYQNRDELFSQSYKIKEFYKKCEKIIQNKVPNGKEERLTFSLLNNFWVFLGKMIEEVKEWEKFYPEGFMPLFRDEDKCRRFSYQLSKIIVITSLRMVFRSVNWTTELIESENQRIESHSKIFSKIVPWEKRDLMFCVFRRKDPSVSDINSKIGIRKIEFLGRDEIELQNTFDKDIQKILEALNISFVPKLNSVEDITQIGLDEALSLLVSLERSRSTFEIARAGYISFWNYKLTCDNLLKCVAIHHRLNYGLPVILFGETGCGKTKLIEFILRNILFQETKIYGIHGRTSEDDIRKMMIQATEFVQDKKQVCNIVFDEFNTSPNETIAFLKNLIFERTIDGKPILPQIRFIAIANPFRLRSKDDPNLTQAGLTFEYSEKIQEVEDLRKIVYRVHEIPDSFFDHIFDFGHLPHQSEQLYISEMVKAVINKLGGVKFPDNFHSFFSSLVSKSHDFVRSKSHDKDSSVSLRDGSRVSKVFQWLLLKDSPGQLFFSEGISTNEKILTAICLTLFVCYACRFSQNERLEYYNSIFSQSKKLEKSKKFKTSNDLENFFNSQNDFEEKIKIARERLLATINESFEFKSEFIAENDALAENLLLEYICAFNKIPLFIVGRPGSSKSLSIEILFKWLDTENKENKYIKKSENDIEPLKAIKPFYIQCSPIITAEAIEGVFRNARTTAAENRHLLIVVILDEVALAEHSPDLPLKVLHRELELCDHSYALGATQTTRSSNDSIEVDNPEPVSVFAISNWKLDPSQINRGILLSRNDPDFDCLKQTTKSILASITDRETKIDEELPYLYQFIVENQSRFINPEIEEINQKQEEEKEKEKEKEIEEEQSISVRNFFGLRDFYSLLKMIAFSWKDSKKVKLSDFWNSVYRNFGGSPEFMIEIEKKITEIFGFQELKNKPSRLELACQKFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAL8</accession>
    <name>A0A9Q0LAL8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAL8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="371" mass="43415" checksum="91C34D0C1DE7499D" modified="2023-09-13" version="1">MEIFVSEEIPKLKTKERKLKIKEKKSRKTKSKPKISKQRISIPNKIQGIFNKGRRSEKITQSKINQIQNQQVFLESEFFGTNSNENSTENSNPNENSNSNSNPNKNSNQNSNPNSNSNSNQNSNPNPNSNLNSNSNENSIQNSNQNEEIFQNRKRELFQKSNSNSNSKSNSNSNSNSNFEIKRLKNQNLIQNSNFNIESGTKKNSQKINQNKKNIYQSFLSNSQKKEIEEKLEEREKRIEMLSEGKKIKENEFFQEFLNEASDNFEKSFEEKLSKKNSKKDQIRKKLFDLESENSKGEEIDFTKDSFQGIIFYQPKLKEEDYGVKIIGKFKEILTKKIEKIILENQKEEKEKEKEEKEEKEFDFSPINDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAZ3</accession>
    <name>A0A9Q0LAZ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger ccch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAZ3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="306" mass="35543" checksum="69F429BFDDA1A4C9" modified="2023-09-13" version="1">MIKQKEKNKLQKPITIPFAFQLQNETLLEIDRLLKNTPNDQELLQMKEKILQAIQLIHQANETEELYKEKIVINEHPTLSIIEMIKTEKSKEKSKENLNENSNENSNENSNENLDEVLEIKEIVPGFVCEVLYKDGNWYKCNVIKTDIIDEKKGVIQSKNLEQEKIMITVELYGYGIETIVAFNKLRKLVLPNPKDFYEGLHCQAIYSGDAKKLTELRFGSRRNSPLFIKTTSNPKETEEKKKKNPDKKRNKNEKSQAAWENFAHAQSKKKRSGFLTQVGKESMFSLKSQKKSITPINPKSRLKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB40</accession>
    <name>A0A9Q0LB40_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB40"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="100" mass="12015" checksum="9D415EFEC683A9AF" modified="2023-09-13" version="1">MRSELYRGMFLSVTEDTSNKVTDYSELSNKSFEIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNNQNQNQKLKNIFLVFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBC2</accession>
    <name>A0A9Q0LBC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysozyme protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBC2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051595">
        <property type="entry name" value="GH25_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208">
        <property type="entry name" value="LYSOZYME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23208:SF36">
        <property type="entry name" value="LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040191430" evidence="1">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="243" mass="27983" checksum="4E497F1FEF67B6B8" modified="2023-09-13" version="1">MFSYIFILLIQIQIAFLYHLTIDTSNKIDETQFNCLTNYTNSTIIIGGGNGKVDPNLAYNLDQINSSEMMFIGIYITPSINLPVLDQIKPILDVLMPYSSLLPFVFYNVTFDSQNNWSQNFSENIQFITTLLDDTWAYANTFVGIYTDKISWTKITNNSALPDFDSYVFLWERIYSGSQNCSNTSTPFGPWNDPDFLRYSISPSQECNVVFNQDLWCSLGLDSSDFHPFFENIKLAKLKKKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBU0</accession>
    <name>A0A9Q0LBU0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HEEDNSH"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="291"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="578"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="951"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1082"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1376"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="585"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="698"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="957"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="984"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="998"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1380"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1392"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1414"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1428"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1447"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1466"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1481"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1493"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1508"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1525"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1542"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1600"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1614"/>
            <end position="1633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5069565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1633" mass="192308" checksum="8B63CE3B2F79D93C" modified="2023-09-13" version="1">MEFYLSNYANQKLKTGGAKKMEELESINLEEDTNETQNSESEIDLDDENQILTKAEEYEYLVNKVRLLPETKAGDSGYLINTSWYSDWKSYIKSEEDDPDYESLKPIDNSILLQNGQVSKSIKESMNYKVLAAPIWKYLQKKYGGGPELRFYYIKLKKDFSPRLEIHKLKIKVKFENKKYQKTKFYLSRTEKVKVLRKKIKEHYDLKENFDLYINYFRIEKIEDENELLGNLNSLEPFNIIIKFESESETKEKSSISYSTSSLNTTQSTGYGMSNSYNYNYHKSDAIRGLTGLSNIGNTCFMNSILQCLHNTAPLAQYFLSGLYTSEINTTNKIGMKGEIAIEFGKLMKDVWSGSYSSIYPYGLKSSIGKYAKQFLGTSQQDSQEFCAFLLDGLHEDLNRIKDKTTTDPVQGYNRNEEDIAEESWKKHKIRNDSIIVDLFQGLFKSTLTCPECKIVSKTFDPSMYPSLPIPLRRHWKFNTFVVFKDPKKFPKKFELHFDDDLSLEIFCERVSQVSGIPADSILLTDIYYHRVYEKITSTEMLLKKTPRDQLYAYELPSKEILESKQNQNQDELKENELNQNQNENQDDNENDNDNENENDNENENDNENENENENDNENENENDNDNDNDNENENENENENENDNENENENDNDNDNENENENENENQNQNQNQNQNENENENENENENQNENQNENELNENENENDNQNQNEDENENENENENENENDNDNENENENENQNELNENENENENEDENENENENENENQNENENEDENENENQDENENENENQNENEDQNENDNENQDENELNENENENENENENENQDENEDQNELNQNENEDNKDSDSDEKDSDEKDSDEKDSDEKDSDEKDSDEKDSKEEQENNEIFNIIIYQKKLIYKFFGSGYTDEDKVSYPLILPLKHGNISYDELYQKILPLVEKFIPFDKIPSEETEEEIQNKQKEKLKKNEEWKQEIQKIRDEGKKARKKLQKERKKLKKERESLKEKEKEEEKKEKKRLKKLRREKKEKKRNEKNKQSEDNNEDQDNKEKDTNLNSDSDQKETQSENQNFTSNIIYSYSRHTDFSTSTSNSDSNSDDISDNEVSEDLSPYITQTSSTTYSSDDEFQDYNFETESLKTGEEKIDKLCEKWEFLPGVHRPFFKIYNTRMYSYGYQNKTIDKFFVNQDTEFEIQWNPNLTENYIPLETFEKQDEEEKKQEYMEGKIGITLDSCFRHFMKEEKLSTQNEWYCPICKKFVQATKKMDFWNLPKILIIHLKRFSYGSFSRSKIDDYVDFPFELNLENMVEREQEYKPIYHLYAVSNHLGFSGGGHYITYAKNRLNNNWYCFDDSHVYKINESQVKTAEAYLLFYEREEPKQFTFRNKAQEDEKNKNSESDENNGDDDNNGDVENNGDAESDEKSSQSDFKLDSSSDNDNDNDNDNDNDNDNDNNNDNNNDNNNDNNNNNDNNDNNDNDNNNDNDNDNNNDNNNDNNNDNDNNDNDNNNDNDNQNEDLITLQSSTNLTKDVDSDNDSDIDENSDDDLDYDSDKKSNENQNKDSNEDSDKNSDENQNEKSNKKSDKKSNEDSNNNSDDDLDKDSDKNSNENQDNNQSDNDSNNSDRETKKDNDEVESEKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC45</accession>
    <name>A0A9Q0LC45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC45"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="578" mass="66878" checksum="154A588A94F2F225" modified="2023-09-13" version="1">MKKKIFLLMKIKFFILLFCFSFFILIVQNQTLKNSFIFPTSISNPTLSLIDENNGFLYYFNYDDSVPSVYFNTIFQIDFNSFKFLNSSYLSDLDQKFQQDFSIIDSIELPESYFEIEFVSSHIDLNNSKAYFILNCNGIFSSDNDQIFKIDLTNFSIELNTSIDADSIYGSQIDLFNQYLYIFSSNPYPQIQKIDLGNLSEIGTLTLIEIFSEWSNMYGIIDNSTNLMYVGFSYYPSLIIVKVNLTDFTKMDNITVEDKDYNDIISVGIDTVNHLGYFVVGVLSYSYTWISKINLTSFESIQSYSFSNYGAVISFDSSTTYAYIGFTNSSFIKFDLLEFQEKNSGLGNFQDPFVILIDELNQMAYVGFDYLFGLVAKIDLSSFQLIDYITNDNSSDKINYGEIDSSNGFAYFFINSQTKISKIMKVELSNFSISEMKILDSNGSIQSTCFDNQNHFLYVGFSNLTDENGKIFKISFWLDLIKIDLDSFNQTSYLDLTNYYPIQTMLFNSIHQYIYFLWESENDGIQICGIELSEMRVLDDYVKIESDQFFSFLSSVHLLIQNPDMDISYFNKVNKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCG2</accession>
    <name>A0A9Q0LCG2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoribonuclease-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCG2"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760:SF1">
        <property type="entry name" value="ENDORIBONUCLEASE L-PSP_CHORISMATE MUTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760">
        <property type="entry name" value="ENDORIBONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="3">
        <location>
            <begin position="79"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="335" mass="37088" checksum="B5159C11FA95D668" modified="2023-09-13" version="1">MLQLNSNQLIKQFSFSPSKFLPKTISSLISKSKSNSNSNSNSKSNSKLKSEKNLEEKSLLKKMYSSSIEKGNLNQENSKTKSQMFIIFTCKKCSKRSGHTISELAYNKGVVIIRCPRCQNLHLIADNLGWFANLDEKERNIEEILKKKGEKVKKITNDLIEIDPESIITEKTDKKILIENHSQNSIVENNLKNLGFELPQPAKAAGIYTPALKIGSFIFTSGQLPTQNGKLFGEGIVPEKVNLEQAQKCAQIATVNALAAIKNEIGSLDRIKRVVRCNVFVSSSQNFNDQHKVANGASELIQKIFGDKGVHTRCAIGVSSLPLNAPVELDLIVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDF3</accession>
    <name>A0A9Q0LDF3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDF3"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="247"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="297"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="462"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="565" mass="64508" checksum="59972F150BFFE686" modified="2023-09-13" version="1">MNNEIFFWGRGSFLLESQKPSEKYKKSPTKLKIIPEEYEIEEIKMGNYGTLILTKEGEIIQFINNSKNEYLPVKKAIQISVGYGNYSYLTENGEVYAKGESIDENKINEIINISSLLVKPDEKVVNICCGVSSVYFLTDKQIAYGIGSNKYGQLGSAPSQDRVEMKKIKSKISRIFSGNYSFGFFCIDLEDNIFACGKNGTGELGIERKNDSIKSLTKVDLKDKGKVEKIVGAYQHSLILLKIGDQGCLYSSGYSSCHGHLNTGDISTFTKIAFFENQDVVQVDAGCYHTIAMTREGKIYGWGLNPSGQLGIGSFTSQNVPTQLILPELTFPIENYYISTGAFNGIFYYVSQSSLRNEFFRFFETKEGFDVELATNTYKKPVSAHNVYLQFIFGKNFPKFKQYLSTQSFENAYSFVKFLYGNSDLKIDMNHKLIFEELMQEKPPNLIVESTVEKMFRDEESKDFTIISQSKFFKVHKIILWARSQLFRGMFLNVVDDSGQVHDYSEISHNSLQIMIDYLYTNQINSDLNEEIIEELTKAMDFFQLDEREPNIVTKAKSKFQKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDU6</accession>
    <name>A0A9Q0LDU6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDU6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="163"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="275" mass="32543" checksum="F903F3403FAD3C24" modified="2023-09-13" version="1">MIFLNEEITPHFKELDEFFMKLSDIKTIQEIDLQKQPNIDFIEFKPIKIYQQRRLNDTLIDTKKESFEFFSIIEFFISNQDDKNKISESKLHQFDKSFKELKTLVEDFGNSNKILRELNHKLVEIKQLVEKTTNLTNKNEKNDEKEEEKEEENLIWKNVSVKNTKFEGFVHISKNDSKSKKKGKKRYLILKENVLAIFESKPEEKNIFPLNVIEIDDSLKVSRAKSTNLNNAISLFSSSSKLGNKKDFFIICETKQDFSKWISLIRKAKETKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEJ6</accession>
    <name>A0A9Q0LEJ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dolichyl-phosphate beta-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Dolichyl-phosphate beta-glucosyltransferase involved in the glycosylation of glycoproteins through the synthesis of dolichyl beta-D-glucosyl phosphate which serves as a sugar donor for transfer of three glucose residues to the Man-9-GlcNAc-2-PP-dolichol precursor to N-glycans.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEJ6"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="98"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="344" mass="40907" checksum="35F4484CEE8FE028" modified="2023-09-13" version="1">MISFIFQIILFFLIFLIFLAIFIILKEIFIQTKTQKLDSDEKQFNDPKNGKVYQFSSEMQIISANISLSILFPLEKKNENYGKTINIKNQEKGNEFTDNLVKKHSLEKIRVLNLNKKQRKEEMVHKGVLISRGDYILVVDPNQEYNHDLIQKFQSKMKEIEKGGFGVIFESIKISKQKLIEKIFYNIFSFFAIRSDKLKLDSQFYSRKAANQIFPNLHYEGYEMNFELLYIIKHANIHSELYEKIITSHLIENENENELKREIGEHSRFTIDNQKAKEMDQIKKFIPFDSIDLDNFYQSKKLGDLLKVLYTIFKVTILYSTGLWKINELPQYYIHKEEVNNFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEW6</accession>
    <name>A0A9Q0LEW6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="10">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_10021</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="10"/>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEW6"/>
    <dbReference type="OMA" id="ICGVFEE"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000468">
        <property type="entry name" value="Short-chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5071612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="362" mass="39971" checksum="9C657BD167297F23" modified="2023-09-13" version="1">MGCLTCSFAKFVDKYLLWLGNMSFKKLTIFLIIVTIIIWIISKKIIDKMMNRINFQGKHVIITGGSSGLGLSLGVLSAQRGAHVSIIARNPEKLKKAIETISSHKISDSQTISAFSADVSSFDSISHAVNKAVKYSGPPFIVIPCAGESLPAYFSQQPLDEFHSQMNLNFFGTVNTIKAVLPEMTKLAADKKKKKEKPKIILVGSAASLLGFIGFSAYCSSKFAIKGLADCLRNEFKALNIEVHIFYPSTMETPGLIEESKRKPSETTEIEGTAKAFSAEDSAKSLFSGVEKGNFHITQEFLIYFARTSMNGLSPVNNIFFDTLLAPFSLIASYIMSVYFDYIVRKGKLAKITKESFEKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF50</accession>
    <name>A0A9Q0LF50_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF50"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="344"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="518" mass="61251" checksum="243B4067450E5376" modified="2023-09-13" version="1">MDNNNNNNNNQNQNPNENENENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSSFFNKFLRGKNDIDKISLNQFNKKEMESILSYIYYGNISFENEENLLQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNQRLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFLPNSFLVDIQNKVIQDNQKEIEEKWKKEVENKNKEIEEKWKKEVEDLKSKFELMELKNNFPQFSDSEIIKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGFNGNSGWINDSNAFIFSLRNDKGDRIPAKFTYNDKGDAICSNLDYGPLFGNGGDFQLSSNLQPGFSNFGHTYNPPNGIIYGTNEAKSYLAGSKNKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF63</accession>
    <name>A0A9Q0LF63_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase epsilon subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF63"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="181" mass="21462" checksum="21AFEFED1C3A3528" modified="2023-09-13" version="1">MEIENKNKNKNKNKNKNKNKNKLRLPLQTVKRIMNLDSKIESISSDAIIGLTKATEMFLELITEKVFLFSQQQNRKTIQVEDLNNSILISNELDFLRLFIEKEKEDSNENNENNENKENNENNENNENKENNENNENIENIENNENIENNENNENNENNENNENNENMIIEIEESQEEKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF90</accession>
    <name>A0A9Q0LF90_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M7gpppn-mRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1434" mass="168022" checksum="E90FAA6289FDDE02" modified="2023-09-13" version="1">MEKDNNNKYKKYYIDTRMITYGRLIKICVQKSYTKLTQILIVNKSHNDPQFKRLELAKYFSITRTLFSKLLIIENAIMRNAIPSAENVNLVQKIHEHFQKFHNPPSALFVVLHRIRNLEIPFFENNFTVNLLFSTRFFSFPKISEKVIYSGETWRGIERERNSRLYTLCCFRLIPKNIRFFRSWEIKNKGIVVANVRGEFDITMSLRIVSLETGIDVGIGVDSDSDIGLCIKKKQNYAIFWHLDSLQLSFKYLKLEHKKIPQLQNVRKILCHKIYAIQKDFYARRGYTEELEIITAQKITENVLKFLHDILHQIYGELYYQLFEKQSVYHESKRRRALNKARLQGANMSAQENKAVETAVASPPPRRRWIQASHPVLAGSKNYPVEQLTTSFFTGFSFKTTLSSLKSLKQRLEMNRKSMWINNLRLQTDRFIPPFCPILRIQLVLNLADIFVRIYDGKFHSQIKTNAYGFQSSFKHFDNFLEIENTKSFWKMPTEFVCSLVKHYIKTKMQKLGMQVFENLPVMIYNPKDPQKNYLLNTELLDIRMMPQRRKDAMRIHTQTPPNEVVAKQMQAMMQTESNPHKHTPQSPINGAQTQIFSRSQAAYRSPEKLIISFFVGTSLRAPYILLFALTSHLRLFLFLIKIKTDKSHLFMTQFQEKIDEIVLTNFATIKQAIDYIGDVASAAKSTIITSSFLFPLRDISIRHCIQNHASLEPRLLISQHDLLKIVHTFGVPLTISRIAVHLLHKPIWEVSVLIPSSSLWIPQLLKYLRIYSKQKDSYLFGMYFTKCSASPFSDGISPSDYHAIIFRYSQIHKNPLSYFLDNFCNLIQNNSIHMLLSHSPQSVPFDFLLRANNLFFIPHIPKPNFLNPNYLLSFGSKVSLYTNSTHTENGSVNLISKLFEVELNRWLNLYDRDCFYILFDFFEKSKSLYAFFNLSSPICDYFYFIPHSLFFGDLYTVYTNSPCLIYLLPQNKLLFCRLRRKKCFATKKLWSKFRDIIFSRLLVSKTHSNQETNSNTDKIKIQENVSNQENMKNQENMKIQENMIHDKIKIQENMSNQENTPNSNNPETQKDSNLAANLILTTDATEITNTLEGKNNKLQTYQKSFSQSTPSFRNQNSIETTKNNSTISNHSSSTQKALQITTQNPQISQNQHKLQMFSSPKFFGKIPKQPQDSLIVPLSILEKFLTQIIPIIKVANDRSKILLQNVYNYLAKSFRNIVKINSKIEIEVQPEIKFQMYLSSNYLNLRGSSKNTGIQRYDIDFLTTYFNSKEYSDETDEKEVCNFYKLLSLPLQILSFFTTFLKITKRMLQKKLEQSQSQSQSQSQSQSFHVSMDLNLKEFHFSSDRNSIRFLISCLWLEHNHPKEEIILQVLYNHSTNNLELPQLDDHAKIILNQIPKNLPFKIDFQKTFFRLVNFYFIDWEFFSYISSKIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF97</accession>
    <name>A0A9Q0LF97_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF97"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="492"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="564" mass="66036" checksum="962EB0EE1801943A" modified="2023-09-13" version="1">MNDCLFFGSNQFPKFIKNKPTEITKPIQFKFENENENENENENENEKQIKQISSGNYSTIFLFKNGKAIEYPREKDSNQNPSKIQIENIEKVTVGWGNEAILTKEGNVFAKERNINPKNPKEFINISSLIEDTNDRIIQDIVSVTRSIYLLTSNQNVYGIGSNESNQLVSNYITLKQKEEPILMMKNVSKIFSGNCSTSVFLLNSNQELFGCGDNRYGQLGLGEPRKDETKIDKLTKIQNIPKGKIIDIQCGYYHSIMLIEIENQNQNPKRKLYSCGSYQYNGLDQDENTYEFTEIKSSLFENNDNILDFSVGFIDTLILTSNSKLIVFGYNYYGQLGTGDTYFYQLIPIQIELPKLRFNEDISNYHISCGFNKTFIYYSPSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNKDTNPKLYSEIKEIINSNEKIEETMKRIYLNENENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKERIAITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFX5</accession>
    <name>A0A9Q0LFX5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFX5"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001179">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="190" mass="22038" checksum="3FB4942CB3F38480" modified="2023-09-13" version="1">MKSIKCVIIGDYLVGKAQTLFSYVREMFPGEYMPTIFENYVENMKIDETEVRLSLWDTTGQEDYDKLRTLSYLKTDVFIICFSFFLPSSFENVKQKWVPEINHFCPHAPIILLGSSFSFSDDKNDLPDFSENSHIISHKQAVELANDINAVKYLECFSLSQNSLKIVFDEAIRAVLDEKSERKRKSCFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG74</accession>
    <name>A0A9Q0LG74_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fas-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG74"/>
    <dbReference type="OMA" id="CFNDPHA"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="5">
        <location>
            <begin position="384"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="466" mass="55371" checksum="08FFF8C41C5B040F" modified="2023-09-13" version="1">MSNLQNFGNERIIQEFQRITKINDEIIAKKILEKNNWNLQMSINQYLFNPNEFDNENEKNNKNEKELEQDNFEWNKNENENENDENKSENEDEKKLQLNSENIFTPIHNLNDEKPKTPIESITNKNRNGNFFSQVVNNVIGFAKNTIEILTKDPNADNQFFLNQIRSIGREYPQFFQGSYQEAFELAKQNEKLLVVYLHSDLHSRTNYFIENILDDPRTISFLNQNFILWGDSIRRTSGYKLSLILEARCYPFLAIISTDSSEETLYQRIFEGEFTVNELLLGLCNSLEESELRKSSTLTKNQNIDSNTSIIQEQDQEFLNSLLIDRERDILEEEREKKEKEEEKKRKEEKERKERQKRERELAWQKELEEKKQNLPSEPENANDSNVLTIAIKLPNSQRIQRRFYKQDKIQVIFDWIYLSSQDALSDSPFTLVKNFPKKIFDDPNKTLEEEGIQNNELLYVLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGJ6</accession>
    <name>A0A9Q0LGJ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhea isoform b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGJ6"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032425">
        <property type="entry name" value="FERM_f0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981:SF1">
        <property type="entry name" value="RHEA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19981">
        <property type="entry name" value="TALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16511">
        <property type="entry name" value="FERM_f0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="88"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="796" mass="91587" checksum="AFF2A3D5F8DDF74D" modified="2023-09-13" version="1">MSLSLRVIFNEKKFNKKMKFKSESKGSEVKEMIGKKITKNFDTKNYHLFIPHEKEGEFIPGEWIKETETLSSYGLINGSIIELKTFLIKIRVKTLSNTENILDINLQENVSNVISQIHKELSLPNPIEYYSLAKCGEFEYETKVLEKSKTLFEQDVCDGSAIIKCVESFYFEKFDQSFNEGDALTTRFECFRKNILSGNHLVGLDDALNFAALEMQIQIGNHDEKKHKPSFIKPKLYLSPLWVLVEGIEKDLIHAHSLIVGMSEKVAKERFVFHVYATKPFSTNFYNTKELVSKKKYKPFVVGITPEALIKYTEDRKTILSIIKIIDIKRFATTINSITFHYLNRAEKFQSFQFFCDQIMEIEELVKNYLSAAVKKKKANLLIQKQIDSQGKTESEYKPSQNKSHKLITESSKYQLEKLKESQNEVIQQSDIGFTNTQINQEILHSTQQLQDISFVSKSNITTRRDRDEFMTSNINEENQNSQPTDYSTISNDLDMSQLLSQKIDSNDLNAFISSKPNTSGNQFQSDYGISKPEQAFMSGNFQSEFETSNIENLMSTNYSEFTSQFGVADPQQISSPNLTTQQETKPNPQFIPQLPHDFSPHNKFDPSPLDFSTQSIEDLLKSDLTTMNQNQNQNQNQSNQTLQFMKTKIQSDLEKANSQTDIQQDPRLTTTALNSFLNTNYLNTTRINPIELNSTIMRSANFVKSFSIFVQIPESNEQSVHIGNVSTFIVNNSVNNLPQEINIREFLSKDSKFQIPNEYIVLNELANNTFIAFTKSQSKLQPNFENYKTRLSFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGQ1</accession>
    <name>A0A9Q0LGQ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA mismatch repair protein msh6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGQ1"/>
    <dbReference type="OMA" id="SHACHIA"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="184" mass="20394" checksum="89FC710A5D45F4EE" modified="2023-09-13" version="1">MGQIGCFVPASYVRFSVFNFIGTRMGAGDDLLHQKSTFMCELEETSTLLDMANPRSLLIIDELGRGTSTFDGTAIASAVVDYLLTTKCLAVFSTHLHLLIDAFRNRQEIQTLYMSFTQTSDHQLVLLYSLVQGVCPSSFGIQVAKMANLPDLVINHANKAVDLFGEYFQQISDNSGKNQIKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHI5</accession>
    <name>A0A9Q0LHI5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein 4a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHI5"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="132" mass="15214" checksum="F8677A5C70AC50B8" modified="2023-09-13" version="1">MSIKITINTLTGEEIEVEINENQKIKKIKQLISKQKKNFGVNEQKLLLDTTELENNKTIKEYGITNGSILNVFIVDNKQDNEQDNEQDNEQDNKQDNKQDNQIDDKIDDPLIPDPVVKSKSDKKCCSCCRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHR8</accession>
    <name>A0A9Q0LHR8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rap gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHR8"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="209"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="49700" checksum="64B2B2A868ADFD5A" modified="2023-09-13" version="1">MASTEENSNQNSNENLNEIQINSNENSNENSNENSNENLNENSNENSNENLNEIQINLNENLNENSNQNSNEDLNENPKEMFKENENWIIEENSNEKSNENEEIKNDTKFRELFYQKEYYSFVFTYPKRGNSLLLITEDSKNSQFIIYLCLKDETRIKMLKKSDIGKSLLRNLFCMGPAISKVIGKIEPDLVNVEVSDVAWEEEDEEDLLKMEEYQNIKQYKFGVIYIKQGQESEDDYLQNEKGSEEFNQFIQLLGNYVDLKDFSQYSGGLDIIDCTSGQRSIYNNWRGFEIMFHVSTLLPTTKDKQQVEKKRFIGNDVILIAFLEGNAKFDRSLFTSKQNHIVIAVRPIKIEKETKYQIGVMRKEGISEFKPKVPIEPLSKDEVTDFILTKACLGERISSKSGDFKKRWISYRENVIETIYEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHU4</accession>
    <name>A0A9Q0LHU4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHU4"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="35837" checksum="E4250BAF2356E0BB" modified="2023-09-13" version="1">MYQPISTFGLKNATITKIIIISLLITFLSFQIFQIDPLKFELTQSKINNFSSFFSSLFLSQFIFVKIPELVLALILIYYFRDVERMFGTRKYISMIYLLFIEIIFSEMMIIFWKIFFGSSKTRIIGSFPMIYSLLILYFFQVPSSTEFFRINKISITDKWIPFLVSIELAIFSLKYNYFSIIIGLICGFSYQFNLFSMQNFQFSSSISFSLIQLLFPFISSSENQNQNQNQNQNQNQNSKINLNPNQNSNQNQNQNQNWNQNQIWNQNENTLNNPRNPNFPHFRQRIQNQTLSQKKKIIGKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI11</accession>
    <name>A0A9Q0LI11_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI11"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="284" mass="33635" checksum="4260D6FCEF2DF8CB" modified="2023-09-13" version="1">MGNSFVEKEKNKIEYFKSIKNYELNPKAVINSKYKFIALNSNFRRILDPKEKETFEGLSILEVSTETQPHLYVETDQVLEQVNRLFKLQAKSEAVVSWTFKNDPKKILEFHLKLVQVEGEIFTEIDAKQDFLEEQRMKERSLSDLKQIYNEVENTVEEIDSEIKDLIEKINTKFQNYQNLPIIQNIQEIHDSIKSSIDSKKDNLKQLENKIENEKELHQKKYLDLEKHLQKRIKRSENSSIQKGNLKKENSLLKKLSQELFSTLNQQNQNMNEILTVLSDDFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI41</accession>
    <name>A0A9Q0LI41_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall integrity/stress response component-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI41"/>
    <dbReference type="OrthoDB" id="2123049at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029429">
        <property type="entry name" value="BBS2_Mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14783">
        <property type="entry name" value="BBS2_Mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 middle region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="441" mass="50987" checksum="235C325A625F7C37" modified="2023-09-13" version="1">MNNFHFQKIFQIVSKISFNCLSIGDIFGFSCCIVVGCDDGSIRFFILENTKNEELILETMGESIQQILISDIMRFGSNDLIIGDNSGNVLIFHNKRIIGRNNFQTPITSLKESNGDLIIGTQNGIISKFDHHETIWKINTNETNIKKNSKQKQEKKQKSIKFLSPVIFKDGNGIETKYLMICRNEKAILFYAEDSFAFSINISSQIETACEGMFLSNLNNSQQIQNQNKNQDENQNQNQNQNQNQNQNQIQNQNLNQNKNQNQIQNQIQNQIQIQNENQIQNQNQNQIQNENQIENENQIQIQNQIQIQNQIQIQNQIQIQNENQNENQNQILLVNQFSELFVFSNFQMTFYSNLKYQISCVATYNIKGISNNIVICGCYSGFLFAYLDGKLIAEEKFNSWIIDIVVGNFKKSKQENIEDSLSIIIGTEDNSIYVYRLIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJH5</accession>
    <name>A0A9Q0LJH5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJH5"/>
    <dbReference type="OMA" id="VFRRCVA"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="134"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="309" mass="35804" checksum="D7F0098A64FD4BB7" modified="2023-09-13" version="1">MSDTDENQNGLKNTHVESESENENKGGGLFDADLLLTSDAELSSNKDLEEEKQEKQEKQEETVKPKEENNDLEFQSFGNKNDQSLEFKPEQLNSKQRKVPELHPPLWSIDYYKEFFNIETKEVFKKMGLSIIPFSTKFYSRKADLYGPFWITTTLVFLMSVSGNLASYMDSRKSGSENWQYDFTKVTFACTLLYGYVFLLPFIIYMISKCFISEKFEMTKLMGSIGYSLSFYIPVSILCVIPNESLRWSLVLIVGIATLVNIIINLYQELKNDGKMNRVLVILLLILLTHLTVVFLLKFIFFQYKEVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJT4</accession>
    <name>A0A9Q0LJT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nedd8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJT4"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="75" mass="8283" checksum="B71A9F7D6FD02498" modified="2023-09-13" version="1">MQIKVKLLTGREVAITVEPTDTVLKVKERVEEVQGIPVPQQRVVFSGNVLKDDKTLEEIGLKHGSVVHLVLALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKA6</accession>
    <name>A0A9Q0LKA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mki67 fha domain-interacting nucleolar phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKA6"/>
    <dbReference type="OMA" id="SDHTHDL"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="80"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="263" mass="31950" checksum="31562DC0BF494EEF" modified="2023-09-13" version="1">MKFSVEENQKENQKENQKENQKENQKENQNQNQNQNQKEQLNFQDSFEKNKNFISIEKKVYDQLQNQIKNEVDSKETEKGVIYFGHIPDYFAEPQLYKFFSQFGKVTNLKLSRNKKTGKSKHYAFIEFEFQKVAKIVAKTMDNYLIRNRIFECKFIPPEDVRQDLFKNVQMKQIYKGIPTQEMFVEKFNKEKDKEEVESHFQKLISKEKQKRDQLKKRGFEYNFPGFESFSKKQEKKEEEEEEIKKRKKNQSNQKKKSNQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKH9</accession>
    <name>A0A9Q0LKH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKH9"/>
    <dbReference type="OrthoDB" id="78358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039599">
        <property type="entry name" value="RBM48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="245" mass="29490" checksum="D5A36AA7F8064FEA" modified="2023-09-13" version="1">MNQKKQLKVYTICQESNYLIIENIPKTGVIKELIQLFALYGPILEYKEIEEKEKKKEEKFSISILIKFLNIDEARIAKKKLNERYFFGNHLNIKYAPNEESLIETKAKLEKRIEEVRTRLPSNKLIKDNSLINKNEIDNQLNKSKNKLNLNPIQNPINFEIDNQNINVKLNKNQNDVENFKQKENLLKIKFQDQIEKLNQQKTQMDQINTKHEIKIIEDEDSEYKREDFIEKKRRNRRKKRINFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKK8</accession>
    <name>A0A9Q0LKK8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKK8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040492612" evidence="2">
        <location>
            <begin position="28"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="180" mass="20011" checksum="202B25DADBB4EC0B" modified="2023-09-13" version="1">MSKKLISKILALIILVLSVILSAISIAEDNIFKAEETVFGLKTKIFYGNFFGFTKSNFYQSQDFITICGYNENDTILLKGVLINAFFCFISALFFLNAIGQIFHKLRAAWILSLIGSVCVFVAFVVAAASWIHSKTYQDFKNLENLGVYVELGYGDGFGLEISAFFLGLLATGILFFNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLH2</accession>
    <name>A0A9Q0LLH2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretion-regulating guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLH2"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF4">
        <property type="entry name" value="PHR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="305" mass="34495" checksum="2465AA540400424D" modified="2023-09-13" version="1">MKNKLNKFHQNFSTIFLFKNGKAIEYSNEDDLNQNPQKIQIENIQKVTVGFRNEAILTIEGNVFAKGKYINPNNPKEFINISSLIEDKNDRIIQDVVSGDSSIYLLTSNQNVYGIGSNEYGQLGFDSKTLKETQKPILMMKNVSKIFSGNSSYHVFLLNSNQELFGCGNNRWGQLGLTKIQNIPKGKIIDIQCGYGHSIMMIENENQNPKRKLYSCGYWEFTEIKSSLFENDDIILEISVGGNTHALILTSKSKLIGFEDNAFSQLGTGDINDPSIPIQIELPKLRFNEDISNYHISCGAFFFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLK1</accession>
    <name>A0A9Q0LLK1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLK1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="77" mass="9249" checksum="6B741A9C826EA93F" modified="2023-09-13" version="1">MEKDEKDEKDEKKDESNQKSNQKPNQKPKDEKPKDEKKDESNQKSKDEKNESKHQSKHKSKHHSKHKSKHHSKHGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLW3</accession>
    <name>A0A9Q0LLW3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLW3"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="333"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="506"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="607" mass="71085" checksum="48D7DD2C62C464BC" modified="2023-09-13" version="1">MNEILFFGLNKNPKLIENETEKITKQIQFKFENENENENENENENENENENENENENEKQIKQISTGNYSIIFLFENGKAIEYLRNSYQNPKKIQIEENIQKVTVGYLNEAILTIEGNVFAKGIYINPENPKEFINISSLIEDINDRIIQDIVSGAFSIYLLTSNQNVYGIGSNYYGQLGFDSETLEETEKPILMMKNVSKIFSGSSSKHVFLLNSNQELFGCGDNYYGQLGFSQKILKHPKITKLTQIQNIPKGKIIDIQCGYYYSIMLIENQNRKRKLYSCGFYQFNGLGKKYGENTYKFTEIKSSLFENDDIILEFSVGNAHTLILTTKGKLIGFGSNEYGELGTEDINDQLIPIQIELPKLRFNENISNYHLSCGEFKSFLYYSPFLSPFSNLEEDLIKLFERKEFCNISFKTENGEIIKAHKLILKYRLNQDENENEKLQEIISKKSTKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSDKSFQIFEYWIYSNQIKDEIEITKEIINEIKRGIDYFQLNQTNPNLFDLLINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLX1</accession>
    <name>A0A9Q0LLX1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exportin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLX1"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="1">
        <location>
            <begin position="86"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-5 C-terminal" evidence="2">
        <location>
            <begin position="320"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="695" mass="81290" checksum="F30D9EE60A847A9D" modified="2023-09-13" version="1">MNYSQEVQELIHCIELIYNPQTDPQQRQLAQNFCDNFKNNIDNLETAFEISQNGEFSATVRYFGYHYLEHIMRNVEESNNGLKDGQNLLEELISLADKGFSERELCLIFIRSFSDELYIYIENPKIIQFMVKILEEHYQKFAQIRDLAQSQENQPQIQDKIEMENEYQSHLKILVATLKAFTSLIDWIPSSEIYRNSLLLAFCNLLTEPELRMFAIDCLIVFGSKTQKISMIRDKKEQLYQLISTICRFSDSLLEENSLEQDYAFQKKFCQFLTIFTQNNSVLFSKPKDEQKEDNLFLDLMLKFSNHSSLMVSSFFNFEENETNPANKYIMIDFLIESEFIEFYKMYRKKLVKLLQILGQKYPLFSLNRWLNILVKLFEGSAQDSSFVSYNQMKALSLGIQAILSRISNKKRQMYKVQQSIENVKKAVNYLLTFQTTDPKFLAQIFSILTSLCLFLNEKTEEIQKILSHLFSYITYKTESDDQQSTKLTEGTQKIRIKAKILPDLTQNFQTLTSNQEIGDEERNNLLKSLVSVSNESKTFNLQEQLLETILNQYVSDLTQLNFIGGDDEEIQQFVSIIGLSLNNIKNIQELANYANNRRKITSLLTLFYEVLKSSEVPKNPKEKSKGDFGPFKIENNVYGTKETNHQNCGIHPSHYRKKLIKSIHSIYDPKIYGNLFTQRTITIHFVIQTSRRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM22</accession>
    <name>A0A9Q0LM22_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin type-iii domain-containing protein 3a-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM22"/>
    <dbReference type="OrthoDB" id="443915at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="407" mass="47094" checksum="D37E61EDD08E5716" modified="2023-09-13" version="1">MSLPTYQNETGKIFCYECPPSTLHNGHKNQRVLAIWDYILISWESPFNGGSEITDYRIQVYEQTNSSNCVLNTTYSNTSYLFYNLSSGLQPGVIYAVKIAAENAPVWVLVSSINYNLQSGYITINWNKPNDNGDPITGYYIIITSQNSSNISFEFSSVFENVSFYWVIYSVSRHTISLLLLRTGSETEVNQMSLFISRLNNLKFPKKSIQSISHIHIPNYKFLISWKSRTGTDRLLSSTQLSLIQQSPDLVLLSQQTLSIYLYSNFSEKSYTIQVFLKILLVQVKSVKSINSLLTKFLKKSLAFIVRRFTNMIIFKWDPSDDLNLDYYEFYSQPEIYNFPKNFTSYSFVMDYSYLTSGVVYVCKIRGHNYVGNGEWSIVQSFESPNNKNKDNKESLYHYQNFNTIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMH1</accession>
    <name>A0A9Q0LMH1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinetochore-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343783at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055404">
        <property type="entry name" value="ARM_KNTC1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055405">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24516">
        <property type="entry name" value="ARM_KNTC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24515">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 second ARM-repeats" evidence="3">
        <location>
            <begin position="802"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 third ARM-repeats" evidence="2">
        <location>
            <begin position="1309"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1821"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1821"/>
            <end position="1840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2071" mass="244884" checksum="6C458B5638F339BF" modified="2023-09-13" version="1">MNFLISKILKSQNIQIQNLKQFKTTYSKQEICISFQNILHFISRNDPEKILNVEFESKIIDYLWNEKTNYMIIIDNKGILYFFNVDLHKIIFSKQIISTPNIILGIKFIPSFQETNSNENENQNQNENQNQNQNQNQNQGKILIISNQGNILIANGVDFSKINQSFQQFISNISFEEDQIANFPIENVIVYQDQRDISQIFFMNNHKSLLCYHINSRITIETGLNFDCKKIHIIGSYGNKLNHLKISCLDFQLVSLKSQNKSFIIFVQKIDTFNLISFPDFKILYTQNINSKLSHNFIFAENLNSKNIKENLKENFFLFTHIIENDQSFELNLSSFEMDDFEKIIDTINQSSFSIDIQQEMFQEKNFGLNESLLFSNLQNQISYQIISSLFINIISRIDIRNEQEKFMNVFQEIKKKAYQLKFQNFLVEIILNSSPFPNFKFFSFMIETLTYCNENEDRSTDKNTTFSLKILLNQTYAKFTTFLMIFDDQLSIKRNHKSSIDNQKDQQFTDISIKWQQFRLTEGFASILYELVHQSELEKALIVWDRHCSIFARINNFEFDMKILLSQISSNLHLNSISRFIWNVFKSTEHKEQEIIVDWLISKAEKIDREELDIVETIKLLQKISSYREYDLFVDSRSINSPGVLVDFLRNEFVPNNSNSDGNEELGNSEYQNLMERKVEQMIWKMKDFLQFMKKRKLFLAKKQDSNETNRAYRSFIQSLNFDFFSHFHNFFEGKPDQLIFAFLTYFNLFDFKDSAFLKYYSTKYEIPLSTSLAKFINLIIDNVEKDEGYNERNSKITQLVNLIPNQEEKIQMILNILRIEPEVLNPYLDELIDKELKLESKLNQELSTQWNLTKLHQILKRNGIQEANIITNLRKMKLVHRFILSKIHDPNALQDALKLSAIFHNLSKFETYRIYLQNLIDSNETKKALLNYCLQFLKENSNQTQSKKIELLFGGNSDEIYAKYLQDCLMVIERMVHLKQNQFIEPKKLEMIKSMKILFDEFKMKFSLEQFSKEETRINILRNIHFEQQNNSNLNYPKMNISGKYSNISQLCEVLHLDQDIGLREIIEWDLKHKNYLSLVNNVSEFLKISRKEKFDQVVQFLEKVNFTIFKTIHIKEKEEEIYNKLEIITSIIYQTLLNSPSRKYFVSLISQFKNINICRYVVFNSLVQNQEKEKEEEKEKEKERMYLMISKRKLNTFSMENTNTKILLQTLLKGSELSMKFAMDPIEYDMVLEDSNNYQKRNDTNDMTMLSFNAIQMNTFIQTQKEALEQSMKILKEMNNHELMLNILYLAEEQEAFPLELVNTIYQQLFIESVSCEFIDHGLSVAYLTSLPCQDGFETFRKCLMETRFDYKRLYQVAKIGMMTGILWKQPSFYQDCKELQDNAYWWNFFQLLQIDFSEVEFLESGDRSYHHSLVPVLLQKTNLDLFLTIEFCECYGIGPDLPKLLFIQLLLLSNDSEDEDVSDYQDKILAVMDEIDTQDVLHLFKDICYKNVNQKDYRKLEYVCNQIIRLESGKIPDEISRDLIILSILENYDKQFCNSETIEYSKIPFHDLMEDPWTVLRPLISEITLNYLLPLVSPLDLSVDQFYRCVFDNLINNQQNISHDSVQKLRYYVDLIRNEYLRIQLYLKICEHMESGTESHSLAQTALQMIAQALLSLQDISEDDEEYHAKINMQIKFQKLRLTCEKLDSKILTSWQLKLNGITGISEQLFNDIPELICRLYQSQSISYLSLLKKKKKRKLDIVNFSDNQPEIYLDNLHLLINDIAARHQLNADKIRSSLIQFWLLSNPEDEAKSKMDGFKAHFVRSKKKKIKELQNNLDSKSNLTTNNNQKQNINPQEKEEISSIDNYILDQLHREEEKNIELRLEYLLTYGKIEKNLVFLLNYAYQKTTAKTTPMSKARSIKLAFTIGTHQQITSLFKNDISKLYSRMQLLFFCSEFSKISMEINVKQLSSVNKEDLVIHLLTNYSQNIQACIIASQIMFDFKINNQDIWQKLFTKLVDFKTHFNYISSFSKSLKISPNTVIAKYQRIISTIHYVSYRGTNDFLKAKKGTNKIHFGKFEIFMAKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMU7</accession>
    <name>A0A9Q0LMU7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMU7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="100" mass="12058" checksum="873BEC8597ED5F8A" modified="2023-09-13" version="1">MYFIITREILKTINLFLSKMNSLKSHWRICVSNAVGLSDFRNRIWNWIDHHCGVHEFCTEFSQNPKCTEPEFRDTQSKIEDTQTRERLEIFLDKEFSQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNT4</accession>
    <name>A0A9Q0LNT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNT4"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="239" mass="27332" checksum="E38A083E3E857692" modified="2023-09-13" version="1">MNEILFFGSNSYPKLIKNKPDKITKPIQFKFENENENEKQIKQISSGRFSTIFLFKNGKAIEYISKDDSKQNPQKIQIEENIQKVTVGFQNEAILTIEGNVFAKGEDINPDNQKEFINISSLIEDKNDRIIEDIVCGAESIYLLTSNQNAYGIGFNGYGQLGFDSETLEKTEKPILMMKNVSKIFSENSSNYVFLLNSNQELFGCGYNEYGRLGLGESRKELMIQKPTQNPKYSKRQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPK9</accession>
    <name>A0A9Q0LPK9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPK9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="228" mass="26525" checksum="67145120BA5DB308" modified="2023-09-13" version="1">MVYCFQLDSTKNTNGDSAIQSKTYLTIPTNNKQKFTHKIGVSQIETDIYLFCLNYLLILKLTIPSNHFDLKVYELLYFLGSLSVTIQTIIRDSVFQMISEIFSIFPNKNQNILGYSNITLDENPFLIKAKYHDNQNISLPFHITDSCPKTRFKRSFVFATTFIMDHNKQPKSKIFPKSTKLGFFIYTQAKLTLNGFDISLLRRNVINIQENDFLSMNQIQLDQKFNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPW9</accession>
    <name>A0A9Q0LPW9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPW9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="228"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="343"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="513"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="618" mass="71871" checksum="D4CCF1A24C6BABD8" modified="2023-09-13" version="1">MNEIIFFGFNHFPKFTGISNEKITNPIQIKLENEKQIKQIVVGDFSILILFANGKAIEYLNGKSQVQIDQETEIENIQKVTAGQRNLAILTKEGNVFAKRSANLFSEQTKYFEDISSLIEDTNDRIIQDVVCGREAIYLLTSNQNAYGFGPNQFGQLGCELPKSTIKMKSNDDFLQIFFPVLNSDPNQQKVGIEDQNEKEKPILMMKNVSKIFSGISSDCVFLLNSNQELFGCGRNHTGQLGLGESRIQEEINKLTKIQNIPKGKIIDIQCGFKHSVMLVEDENEDENPKRKLYSCGDWLFLGLDREKKKEFTEIKSSLFENDDNILDFSVGNEHTLVLTSKGKLIGFGHNYFGQLGTINKAYELIPFQIELPKLRFNENISNYHVSCGFDNSFLYYSPLSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNEIEKLKEIISNKSIKESNQIFEMIYSNRIINPILYYEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERNEKQYKFPKLILIMRSELYRGMFLSVTDDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQTGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQG8</accession>
    <name>A0A9Q0LQG8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQG8"/>
    <dbReference type="OMA" id="ITTIHKY"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="408" mass="48756" checksum="B25CFBFA18A82E5F" modified="2023-09-13" version="1">MKLIINNPMTYYIGDLLLWVAYNFKSKTAGIWKKLIKNNRTNPDNLEIILNEEQNQITLNKLNNPFSESNQKKNKYYKTRLGNYRNVSEILLYNPYLDSLVDCIREFSKIDSEPDPNSSLSKLLKKKRNYPQKLIEKKQIIDVDNFKERLILVYLDLFINPENSLSLHEFSKEKITTIHKYLKYIYPELQMYILIDLKKILDNKKILGFFRKNNGCEILFSDFFIRENSLKIAEKIDEKLGQMNIDLQTLLIDLIYNIIIRDQNSLDYQFLFQKFFNNIFSINLLIRIFEIFIQIIGHDPQISANQLISDSNFRQFLSTYSELNTIYNENQIQNQNQIQNQIQNQIQIQNQNQNQNQNINENENQNQNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS51</accession>
    <name>A0A9Q0LS51_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS51"/>
    <dbReference type="OMA" id="YSELAIC"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="326" mass="38470" checksum="911BF532C54F2B9F" modified="2023-09-13" version="1">MIEQEKEQNLNEINQENPKSINGFTSMRHQVANEIFTTEDVYIKKLTILANEFSNELINFAKNDRSFISEKDIKAIFDSIKSILEVNFQLYSELAICMNPWNDEAKIGKAFLQFIPFLKIYRNYIENYDNTTKTLEKFAKTPKFSSWAQEKKMEHNLLDLPSFLIMPVQRLPRYQLLLKELVSNTDQSHCDYTDLVKAQEEITKVNNFVNESIHKRENDAKILAIQKKFSNKALKDLVAPHRKYIYDSPLHKLYGTKKIKLHFFLFNDIIIYGTESSGSYTLYRIMKINFCSIEEGDPQQLQFFIQNMDKKYTIFAESKEEKRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTD2</accession>
    <name>A0A9Q0LTD2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cxxc-type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_00245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTD2"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5076925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="375" mass="44714" checksum="752D7860ED5879FC" modified="2023-09-13" version="1">MQFPLRQQMYYFLPYSNNTNAQKQQAEQTITPFFHQNQFMSPFSPTKTQNHNQNSNKTEDLKQSYPLLYVLALVSEKFNSDLNFTQKFDFPVFRQLDLSQKKTKNNKEKKQTQSQTQKHKEKQKQLKTPHKNLNQSQNSTENQNQSQNHLKSKPQNFQKIQTKTEQHTKETQFKTETKTETMTETETKTKTKTLTAFNPKTESSIETITRVKRNAENDLDFLNEIKQRKTNLNLKEKRKRKRKRKRKRKRKRKRKRKKKKQKQKQIKQDQTQTKEEKEEEKEKEKMTDKSKSITEIETINQRDIDADIETGFDIEENDNNDDSEDLTRCICNSTLTRGVMVQCDKCGFWLHIDCLGFTSVDQIPDVFICPFCQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTE1</accession>
    <name>A0A9Q0LTE1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sorting nexin protein WASP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTE1"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin protein WASP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="189" mass="22323" checksum="95306723AC48D017" modified="2023-09-13" version="1">MRLSILWQDLSRTSFDWRSKIPENAQECSKQMQAVFEALGSTWQTIAKTYVNQGRFELNRISIPFHEYEQMVDNLNLPFKTREKAQLDYHQIENSLIKMQKGDGYSGKDNQKFQNFTQKAKFAKKASDTMTNIGLAEANFFRVNRYNDFKSMMLEYVDSQISFYENIANSFRKIRPLIEQINVQQDLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTH8</accession>
    <name>A0A9Q0LTH8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTH8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="174"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="237"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="292"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="458"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="563" mass="65592" checksum="45C88A2071096FE0" modified="2023-09-13" version="1">MNDCLFFGENETPILIKNESNKITKPIQFKFENENENENEKQIKQISSNLFSTIFLFENGKVIEYLNENNSNQKIQIEENIQKVTVSWRNETILTKEGNVIAKGKDINPNNSNEFINISSLIEDKNDRIIQDIVTGDSSIYLLTSNQNAYGIGSNDYSQLGNSSQFVFLLNSNQELFGSGYNYSSQLGLGESRKEEKIQKLTKIQNIPKGKIIDIQCGYTHSVMLIEEENENQKSKRKLYSCGDFSYNGLGKEDENTYEFTEIKSSLFEENDDNILDFSVGDAHTLILTSNSKLIGFGDNDYGQLGTGDTNDQSIPIQIELPKLRFNEEISNYHIYCGYFNSFLYYSSPSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNEIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNKIKDDIQITQEIINELETGIDYFQLNQTNPNLIDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTR3</accession>
    <name>A0A9Q0LTR3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTR3"/>
    <dbReference type="OMA" id="KIYATHG"/>
    <dbReference type="OrthoDB" id="18598at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="848" mass="96052" checksum="9872B70BE695AF37" modified="2023-09-13" version="1">MTAPSLKTVTIEDRALIDSLMKNKKEKVLFYTWIRKQKTEKKIEDRILIITKYRVLTIGKRKGGIKKKICRNGHLFELKELTSFNDQHVLMVFEKFRIDAYSTESDEMVETILTNYLTISQGFPPDLFVKFVCEPEGRLGPFDLKKKPGFGIAQMYKAWCNFHETIPNKEFISFMIKDTISNEEMETTALDFTKFPGTVTLLSNSKDIDPIIDTLKYNKYFRTLIIKGIKKDLITSISRSIRENTTLSRITLSGFNSSSGIDLLGQALESNKNLPLKYLDISFNKITSSTVNNGLGIGLKEMKSGLETLNVSYCDMPSKPTARFFQFLSGNKNHTIFSLNVSGNAFRKKGSLAFAEWIKSIKETDFLESLDISKCQINFPFVFNALNEHYRTKKLRILDLSENKIQKNSIKSIREFIKNTTSLSEINLTETNLLQEEVAQVLEDILSNSKLKNFVLIIGGNTIGPKGASLITEIFKKYPDSQTLSELVIDDCGFGAEGITNLFGDTSSGIFLNKSLRKLSLSRNVEKVKLTKLNVSHLANILSHSSLEYLRIRGNNKYSLGSGMKEALASMKTLDVLVLDIIGNDIGGLGVNELARILSEKSTKTLSIHFDYNKNTLSSIQSLAYCFKSNTTLMSVQWPKFDVNKMVVSANKKEKKNLRKNLKSLKEEIMKASSDNNTGIEIPTMSSDHYELRFAKIRQIGLGEDETQYWSEYENFKSITSDFETETEESESNIAHNLEDNIKSPPLAKQQNKILENIIPPPLNDKDIQNLENIIPPPLNDKDIQNLENIIPPPLNDKDIQNLENIIPPPLNDKDIQNLENIIPPPLNDKDLQNLENIIPPPLNDKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVI1</accession>
    <name>A0A9Q0LVI1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVI1"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="264"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="47212" checksum="22DE347066D07483" modified="2023-09-13" version="1">MNEILYFGINIKPKLFKNEPNQITKPIQFKFENENEYQYQYRKENFNEIQIKQISPSNCSTIFLFENGKAIEYSEYLNKSPQKMQIENIQKVTVGSLNDAILTKEGNLFAKGEDINPENRNQLYNISSLIEHPNDRIIEDIICGARSIYLLTSNQNVYGIGDNRNAQLGLKKPKKTEKPILMMKNVYKIFSGNTSRSAFLLNSNQELFGCGDNRYGQLGLGESIKEKKIQKLTKIQNIPKGKIIDIQSGLFHSIMLIENENEKRKLYSCGNYEYNGLGKNEDEDAYEFTQVKLPLFENDDNILEISVGDMHTLILTSHYKMIGFGYNYYGQLGTGDTNNQLIPIKIMFPKLRFNEDISNYHISCAHEKSFLYYSPFLSPFSNLEEDLIKLFQRREFCDISFKTKMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWU4</accession>
    <name>A0A9Q0LWU4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWU4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="403" mass="47287" checksum="0033DB5FBB5057F1" modified="2023-09-13" version="1">MSDKETFENIEESELPNIFDLVKAPEPDINLILKVAGSGVDLNISEEDTGMTPLHFACANNNEDLVKILILHNAKVHITNKQGFFPIDIAYQNKNLAIAKQLLQEKNQEEIERLGLKVNDMRGVDFSARNFEPELLHYISYFIAINIKQIIENNSVNFGEIWNENQIDVLTECIYRSLDENNSVIVLNKFKSLPKFKRLMFAALYFIIKKFHTLPDFEKYNILHEKQDPRTWEDILINVNEMMQLVNVDNCIQILGTFCQARLKMIAKYKKFVTESFNPFFLRFMEKINKLCRNNFDFLPKGKDVVIARSLTHKNVISVWSFARKYKQHFIEEQCFRFLKDSDFSEIEKKIFSEKFIIISESDIVISIQMRDLTVLKFEEQKNKENLDEELAQINTQLQISQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWV0</accession>
    <name>A0A9Q0LWV0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermatogenesis-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWV0"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="711" mass="82721" checksum="0E12AE51584AEF10" modified="2023-09-13" version="1">MISSYLIKKPHSFQNYFLKSFSNRLSKESSLYLQKHANDPVDWFPFGKEAIEKSKKLNLPIFISIGFNSCHFCHKMHNESFQNKAIASILNKHFINIKVDREERPDLDSIYIHFVSMFTGNAGWPLSVFTLPNLTPFFGASYFPPLQFQNLLSQISEKWKDLSTQKMLEKNSQQLQTELKRVFINNSDKQKSNDQTSKIQIDKKRAYQILNKTIEQFLSIFDEDNGGFSTPKFLLPSVLDFLIGSQIMNPLSHLDSKAIEMAITTLDKACERGIYDHVGDGFFRYSTDEFWILPHFEKMLCDQGLLVKTYLDAYKITQKIKFKEVARKTISFVFNYLYNKEKKMFYSSIDADSFPSEKGSNSTGKEKDMQELCEFFTIKENGNIPRDLNSNSNFVSKNIFYINKEKEHPINSGFHPEMISKSLKKLENFRIKNRKIPEINSNIICSWNCSMISALAQASSLLHSFDDSKNISEKESTNELAIYAQKTLESVIDNFVDLSTFEVSHFLGKKKGFLTDYAELVRALLDVYEYCNQDFKYVELANNIFAKYNELFWDSEQNNYWNFAKGEEVIMQTSNIFDGGEANPLTISIDNMIRLSYLLNNNDYLKKAKLFFEFSKRFQENPSIASSLLKPFRELYFSSPTQITILSNPKSEKAKKYHSYLTKETIPFSNFDESNKKVYYMVCQNETCYGFKEFDESTKMIDIFPTNKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX77</accession>
    <name>A0A9Q0LX77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX77"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="463"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="568" mass="66005" checksum="26D8F78A7D6F31C0" modified="2023-09-13" version="1">MNEILFFGLNEFPKLFKNEPNSIKKPIQFKFENENENENEKQIKQISSGYFSTIFLFKNGKAIEYLNENDSNQNPPKIQIEENIQKVSVGYQNEAILTIEGNVFAKGEDINPKNTNKFINISSLIEDTNDRIFQDIVSGDSSIYLLTSNQNVYGIGSNEKGQLGFDYKTLSKTEKPILIMKNVSKIFSGISSAHIFLLNSNQELFGCGYTEYGQLGLGKSSRATKIQKLTKIQNIPKENFIHVEIIDIMDLAKMKMKILMNLLKSNHLFENDDNILDFSVGNLHTLILTSKSKLIGFGGNFSSQLGTGDTTNYQSIPIQIKLPKLRFNEEISNYHIYCGFNKSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTKNGEIISAHKLILKYRLKQNENQIEKLQEIISTKSIKESNQIFEMIYSNNSIINPILYSEIKEIINSNEKIEETMKRIYYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIKITQEIIEEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX93</accession>
    <name>A0A9Q0LX93_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000004">
        <property type="protein sequence ID" value="KAJ5080672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX93"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="96"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="270" mass="30987" checksum="5022825B9DB26882" modified="2023-09-13" version="1">MDKNNNNQNANQIENENQNQNENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKEKGKENEIPKSKLDRKKYKLKVAKIFSDSRIVQDIEYAKKLQEWINDNDFFSKMKKGFSAKRDGFNSKNWHKAVDGKGKTLVIIKTKQNFIFGGFTKVGFNGDKGNINDSNAFIFSLRNDKGDRIPAKFTIKEPQYAINSYLNHGPFFGNGDFLLGSDLKHGLSQFGSRYNLPNGITYRSNEAMSYLAGSESSWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYI2</accession>
    <name>A0A9Q0LYI2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000024">
        <property type="protein sequence ID" value="KAJ5079625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYI2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="678" mass="80101" checksum="5CB595CACD7AC1F7" modified="2023-09-13" version="1">MEICKIIFENQSNLLNLSSYPNLENLKSKISSYFDQSIQISKIFYFENNQKILILNEDGFQIFKGLVSLENSQIEKENERPVLHLEGISSFTKKKQPQESLKEFIETCPCLDRKDESNEVLCKICDLQFHPSSKKKVERHLNSKFHHLNSSKKIKTHRDLVMEQIGEDFLIKIEIINNLLEDTCCLDFFSSQTHMNFRTPLTKANENENENENENENEKEEPTRISYEQFCFISNKFFLLKCGKSRFFECGICAQNPIPINHLQYIKNIRNYFQSCKNDPDTLIIVLDFAMNIQQKQDYWTTEQWYKRKSWRLFNSTLSGDSLSYIDFISEDSHKDQYYVISALRYLKNFLEYQFETKEFTQRRRVVFFSDGGRHLKNNQVPIIIYDLFHSLFQEIELVYFESYHGRNLADSHFGNISRQKVSVSQICSILDLFFFLQKLQRTYPIIIEVDKSQVIQNVPKIPLLHNQHHFIFTDNSIILHDFLDDTNKRIKFPKLLRTKKVIPNNENIPNEKNSTRSQTNSQKKRKNIDISQSKQQGEMNKKNKIKNNSNQKLLNLKSISQPLNFLNQNQLSKLKQKQKLNLIEVEKKEKKIEIGKSIKFPKEILSYDRTFFDKNFRVIPNIGNSCYLASILQCLIRTNFSQLNGIGFITIILETMLKTSNNHFDLRFLHDALAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R412</accession>
    <name>A0A9Q0R412_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R412"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040181247" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="470"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="900" mass="101932" checksum="E406B929C4439965" modified="2023-09-13" version="1">MKLILFFSFFLIINIFLIQSNQNQDQNQNQQKSISTIIQELETTRLLTETTRYYSTPDEAWIWNLLDQFSLPALNFGISVSVYKDVIVIGASDAKQAFIYRYNGTNFELEQILNESTSNFGYSVSVYEDVIVIGAHGANEVFIYRYNGTFWNQEQNLTGPFSWFGHSVSIYEDVTFIGAPLESKAYIYRYNGTIWNLEQTLNESVSNFGWSVSIYGNVTVIGTIGGNEAFIYRYNGTFWNQEQDLSGPSYSNFGSSVSIYKDVIVIGAYDTNEAFIYRYNESIWNQEQNLSEPSASWFGYFVSIYGDIIVIGAIGTNEAFIYRYNESIWNQEKNLSESTTGFGESVSIYENFTVIGAPGANQAFVYEVNLIPQVNIVNCSTLFSSFDCYWDEIQSSLTLIYQINYGYDWIDIDYPILEDENVYYQQFNSSIYDNITGNEYYSIQIKVCDNETMKCGESSSFINLTTKIDSVKDFQLSNPSNNSINVTWNYPNVQINEGIAHLDHYNLSYFNQSQPDLISFISVDNSSLDYFLNNLECENDYNISICGCRTQECEGDDKGEIVESSISLIFGEITNLTCSISNSIDINCNWNQPINCSIPFYYNLTYQSISQNDSGNYQPTSSNQQFTVQFPNQEYQINISSCNSNGKCGYISSISITTDNLTSPTIYETISKIEEIEFNFTKLTNSNNYSISLDNETNWEKFTSLDLSGNEIIGRISEISGNIEYNISIRGCVDLNCETPYLGLPSSIISTRAKLGNITSLNCNSLINGFECTWDSLILSSGLKAYSFTYNSTSICLSNLTTIYSISSGLHGGEYYEISIYSSADLNCSFNQYSGINSTTSITIPTTNEPNNNSNRILITLGIIIPIIVISIIIIGIILYKKKKRKKLIKEIIKRKRTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4A4</accession>
    <name>A0A9Q0R4A4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-coa hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4A4"/>
    <dbReference type="OMA" id="WRSVAFS"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="246" mass="27235" checksum="DEF365ADAAAA1CC6" modified="2023-09-13" version="1">MSGSIGVIEEGLLSWMILQNSAHRNALTTKMWAQIPEVLDNLSRKKNRVVILTGEGKEAFGSAQSEKYQKLIHNAIESIKNFKAPIISLIRGYCLGGGCGLALSTDLRYATPNAVFGITPSKIGLGYSQEATEELISAVGFPNAKEILFTGNRYDSQKALKMGIINDIFDENSIENKVRKIADIISHNAPLSVQHAKITINELMKKDEKPNTEKIQKSFITCIKSEDYKEGILAFLEKRKADFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R523</accession>
    <name>A0A9Q0R523_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R523"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="476"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="70384" checksum="1C0931B93BC80EDB" modified="2023-09-13" version="1">MNEILFFGQNHSSKLIKNKPIKITKPIQFKFENENENENEKQIKQISSNSFATIFLFENGKAIEYSNENPSKIQIENIQKVTVGFQNEAILTIEGNVFAKGNIINPKNPNEFINISSLIEDKNDRIIEDIICGGTSIYLLTSNQNAYGIGFNHSCQLGFDCKTLKETQKPILMMKNVSKIFSGNSSNHIFILNLNQELFGCGRNEHRQLGLGKSRKESQIPKLTKVQNIPKGKIIDIQLANSFSIMMIENEDEEQKRKLYSCGAYVYNGLNQYVYEFTEIKSYLFENDNILDFSVGFTHTLLLTSNSKLIVFGDNAFGQLGTGDTETKSIPIQIELPKLRFNENISNYHVLCGYEKSFLYYSPSFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLRDENEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENEKENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIINEIKTGIDYFQLNQTNPNLFDLLINKFQIKIKMGSKSKSKLKFKLKSKRIFNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5L6</accession>
    <name>A0A9Q0R5L6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase iii DNA directed 39kd subunit-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5L6"/>
    <dbReference type="OMA" id="VGTTKKC"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="274" mass="31615" checksum="71BFA4E4860D3625" modified="2023-09-13" version="1">MSDLVEKLLKLFEDKEILEPKEIEQELKTRQGLGAAINQLLKEGRLRLMKKVENNALLLRRIPDSEAEKFQGLTQQDMFVYQIVERSANQGVLAKSVRTFSGMQQPIVLRSLRKLISKKLIKTVRSIKYKNQMLYMLQDLTPSKDLTGGVWYDNNEWDSQFVEEVSRHVVGIIRENGNVSINQLMAIIKEKKYIKENLALEDIQQVIGSLVDSKIIRKVFDIVDEDVYSIDDSRNYEPEITKIPCGLCPESSRCYHQGVISPENCPYISKMLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5Y1</accession>
    <name>A0A9Q0R5Y1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein kinase fray2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5Y1"/>
    <dbReference type="OMA" id="HRAKARY"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="504" mass="58396" checksum="D47BDFEA18147BBA" modified="2023-09-13" version="1">MSENTQKKYPTNSQDYELYYEIGFGATSTVWKALCIPFKEIVAIKIIDLESISISVEKLFKEIKYWKLCQHKNLVTFYCSFVQNTNIWLVMEYFSEGSCHGIISYKYPRGINNESIIATILKETLQAIVYLHENNQIHRDIKASNILIKSNGEIKLADFGVIGSLSDHPKNQCKTFVGTPCWMSPEIIEGLQNKKGYNEKTDIWSLGITAIELAEGKPPFFHHPSMKIFLLIVDNPPPSLSQEFSKPFQDFVNLCLRKEPNKRPSAQKLLSHKFLKLAKKPEYIVENVLNNLPSLKQRTDEMKKKKLESVNVKNEPNWNELVTSPNSGDQLNQNQNQNQNQNQNQNQNQNQNQNQNQNQSQNQNQNQNQNQNQNQNQNQNQNQNQNLNQSQNLNQNQIPRTKFKAIKAKSGQIKPTQKNSNKMKPTKANSNKIKSSKTKQVKKSKTNQTKSENPQKIEKKTTKRIYKITKLDKPPTKTNKKEDKKTNYDSPNWQELEKLYNNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R634</accession>
    <name>A0A9Q0R634_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R634"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="477"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="558" mass="65067" checksum="64D6FBFD97A28EA4" modified="2023-09-13" version="1">MNDCLFFGFNKNPKLIKNEPETIITKPIQFKFENENEKQIKQISTSLFSTIFLFKNGKAIEYLTQEDSKQNPSKIQIEENIQKVTVGYENEAVLTSEGNVFAKGKDINLKEFINISSLIEDPNDRIIQDVVSGYNSIYLLTSNQNAYGIGSNYFGQLGSQSIQKTEKPILMMKNVSKIFSGNDSGHVFLLNSNQELFVCGYNQFGQVGLGESRKEETKIPKLAKIQNIPKGKIIDIQSGFYHSVMLIEQEDENQNPKRKLYSCGYNLYNGLGKYEDTYEFTEIKSSLFENDDNIIDFSVRSAHTLILTSNSKMIGFGHNQQGQLGTGDTENQLIPIQIELPKLRFDENIFNYHISCGYDRSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYFEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNQIKEEIQITQEIIDEIQNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6D8</accession>
    <name>A0A9Q0R6D8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dmt family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6D8"/>
    <dbReference type="OMA" id="TITGYLW"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="416" mass="47410" checksum="90A7FA7748D0E481" modified="2023-09-13" version="1">MFVVNLILTVVVHVCYGFYATLLDWIQSPDHGKMGVFILLVASNLAGLIFFLTLQLIKNRGLKNPFYRTTIFYYLRGKTKSVWFLFFFTSTIWIFASFASVYSFKLAAHPSTIQAITLLMPFVVFFLAKITKIAKTLPRFILPSFVLSVGGCIMMILGSVNKTKEKGDNDAHIKNIISICLAIFFDLSAACFFVLQQKVCKVHKVPAEVLLLTEKEIYVPLALIFSFIFPDQDWNVYKTLGTKGWIYLIYITVGAMSIARFGQAKMVVLIGAALYSSVQGIRLPSTMVSDYVVLKEDPHWPLQYIGAVIVFITISLFLGYQAFADKKTKGKHFVFDPYTFIYIEEDDDEFTMVNPLDEGLLKDYELNELHAKQSMKKIEKISSSDSDEKFDQKDNFRDDNFDGFDKDAVHVNEFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6E7</accession>
    <name>A0A9Q0R6E7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inhibitory regulator protein ira1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="TKEPYMF"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1194"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="5">
        <location>
            <begin position="1530"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1406"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1930"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2199"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1408"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1936"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2199"/>
            <end position="2228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2657" mass="306127" checksum="871FA39E012FF311" modified="2023-09-13" version="1">MNEEEKTLTTITTRIFNQLPIKRFEQTQSQLIFLAEEYIEIYFSMEIEILVSLSITRLESVLRVLLGLLRDISQKVVDKNDERFSSVERSILIVFECMIRCYSHSYKMTEEDLENYEIDNKRKLIPDTLAEQLITLFIQICQEKDHDDYSGMFEEYFGKLISRISHLNYEVAFQHVVKVLESIKKSKENTEVKELDILKYLDYNSKRLSQMFQELAKYLHFFQKSQMEPISISLREAIWNWINTNPSEFTKLSQSEKTMDGNPDILFDHFKRWGGLMKKKSYIFWPIQTMLLILCPDILLGIAKAKKEYLSSPRGEFLETLKKTYRNKGEAPDMAALCFVDLCRASTYVSKEDIAALRYIVPTVLPDLKKKLYSKSKPFRDNNVLVQLLVSSFRINPRDLFDVCLEKDAPPLFRSILLKALLVIAKEEPLPWNPHLSAAYSISTKVKDIFAEYLSNLKSLQINQSGEARTTMISTLVDSSNIKKKEREKFEAAKTHIEVVNETLKLFSQDPEFALCPNNTTPDEITNEISELFMDITSCLESSFSNEITHSATLALKELFKPKIMEKWCPKDVMNSFYDISSTVLFGISHLIIESKEISQEKIQTLLDLIQDLLKKRNEFLISHKREREGYQKEVKKDIVQHHNRTNTKIEQALLILLCNSDPVVCAQAAQCFDSLCEETKMIGDLNNPENTVAVSYNYYKRLVQVGQLTTGKIAQQKGIRSLFRRIDVATNGNKLVWSRIYERWNDQTKIIKYSSKIPDAIETDPQTKKTKQKSKSGDKSFSREFSDSELNRIKIEWSNYTGFLCSLSGVGKSIPETSGPTTVQKSDEKTILGPFIQKLLALIVSPIDFIKETIVPIISTLSPSVYSQFFDQVRDKIAENFSQDGHVSSTNERSTLFYDQLISIIRNILEQPLTLDDLSEIDFEKLILQIVTYLSHIFVDIDSLRIKCKLCQLIEIMMNKRDYLLFRHEIQFRNELVEAIMEWFSVYQKDSTSPNSQQNTNENLTPLTQSQSTNTNQAKDSLDSYTNLNRMKRELDITTMKAIEKLLDGLILQKPWKGEHTKQPTAEQVVEQRSEIFLQYFTFFSSMLQRLQKDKESSEDAKKLSQHTIMSLSNMLHANVNVGLKHALPMGYINDIESRSAFLDVLTNILKQGTEFASLKETAQNKYNELINLLVSDDLFVTKAVCAITQVTDTDLIAKLLVHIHEGESKVMNLLRWAIQDEVKNTPQDQPQMLFRRNSPASKMLGVYSQMIGGAYLQKVLEHLTKSLSNEITINKKTFEINPSMVKEGESKEVNLENLVNFTTQFLDKIIDSISYVPRKLLLISPLFANISIISPENHNIISERILPEVRRALILIAKTIQNLANGVMFGKKEEFMSPLNTFIEQNQNRFDKFIEDLLKKGKETENQINQEKTPKTKTQTGDLSENLETEQVQITDEQLTEDLESLHHFLNTNMEKLSVHFKRQQDQKNVKIGEKFLSLLNELGKPPEKKNKKEALGVVRETKTITEDSHSENTKKYKKFKDFMKRMESSDTSRLENIFFQKGKTKTGELVFYFITRRTENSEDKGAIIYYILKTFEEFFSKRIQPFVVVIDCSQFSSSHEIPKTWVSQFFSIFPNSWTDNFKEAYMIYPSSGLKKYTKKIGKIISHGFGSKVKIMDSISKLFSIIPESEKELPQETVELETTIKFRFPQIIQVSQFKQREATFNISNQYLQIVQSKESILNTQTNLFDLIHVMDIQEMQLSDEIPDQFMLKMVVNSDQKNLSYRSNSRQEIIQAIQTTKNRIEHQQKLGTNKSGMISAEVRPADVPGSLLNIALLNLGNEFETLRKSAYNLVTSLCRSFNYSLQSQLLETEGLCVPQSHTSFVIDLSKKLAQSEKHLTLEFLRECLKYFRQASLHAKHLCLEYMAPWIPNLKDYVCKYSSINNSDDSNNNKKIQKDNNNIDKKVNTEESNESKRAFAKAVIVDFLEMTIREKTLYPAVLIHVWRTFAGVHDLLDIVIDVFIEQSSKYGVDTPSSDMIAQITVTLASMDSKYVSIKLCDTVLQRISSVSKSLQNQEKTKIEDYEKWDEVLIMTRFLLYLSFENLISLRNTLPELFHIILMIYSSDSLFMRTALLSLVINIIHSLATKLPPQNEQKQLDLRAILNEVTQPRFRVLFMGSGGKKSDIISEGFSAISSGLTGINTTGISGKNLSNIVKKSNKENSNENEQNKSEDSKNNQDEQQEDKTKISGIEPVKKNITRKPLPKLPKKYYKMEKITISSTDQVSHLFREVIECYQNEKQGKDWHKKWLELTTFSAFQTSLIQARAMVVLGNLSEPPIANSFFARIFSYMQPLICKEELLEREIDILTSIIICLTHLYPLLEGSNMKFNMFWVTTCLVQYGETELFPYLIKMLHVILENLDKSGVFDNNDIDEVFMDSRNKNPQLDRLLSDFEEHMGMIFRMGFPVALTSVFLPARKMPTLKNALIGLFQTMVDISCKTGITANKAAYIVSLGSCLTTKEILDLRARLGNYIDWEGELEQLFFNPVMQQEKNTANLQVYLLTSLLIQSDYDQEQLFILDILNYCVDVFPQVFPTVYHLLSLKLFHILSHTQNPHVQKSVLKLTNFMLSDKSRRIPGQLEILGFKNLNKFINSPIDKADKADRGQIISEVLEVVTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6H6</accession>
    <name>A0A9Q0R6H6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="2556"/>
            <end position="2650"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2667"/>
            <end position="2942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2444"/>
            <end position="2560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5068263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3309" mass="396387" checksum="84B3AA14D49CD96A" modified="2023-09-13" version="1">MNKNKLKLKKFNKFLIKQANKQIGLIFENEESSDFKIYCGKDKISIPCHKFILESRSKYFMIKTKENQTNSIHFKNFSSEIVKPIIKFFYNGKFKFDKQKFEEYFNFANQIKSKEIKTKIELEIELILNVENILEMYFKTQKIKSKNLLQICQEFIFQNVQIIISNPNFEKNLNQNQINNFFGLISLNQKIENKEEIIEKFQQKSNREKDLSKIEKLEQIEEQKEKEFFTSFPNGNQLFKIWKEIISKYYTEINEKIIEFCLLFRNSFQKWDPIQTKSKQNEIENENENEKYFENEEINEAISQKEAHPIKFIHFMISLLTYSKDLIKEIIQKEKEKESIQAHKDLISLSIISIISKSKFNRQILFENGIFQIIQDLLKITNHLLKLMENLRKSNSSLSIYYLIESQFILSETMEILNQFFRPRQVFPNEKILESFKKTKIISLLIECFEINLNIRKSFIFTQKQFEIQLQILENLEICYELNLLTEKEKIELISFLLPFFKPPNLSSFLPNIGFSNEENQNEIKDFFQTNFFIFDPKIKKEENRFISQNLKISKGNLIYLEFDFESNIFKFLTKIIEKENIIEQIINNNNILYLGDFILWVSYYLKPRISKNWNEIENENQNENQNENQDINPKKISEINLYNHYLDTLFDHFRNFQNIGKSNRNINNLSKENIRKELDKFTNENKRKVNNFKERLILTHLDLFKNPENQNENSSLIHILSNQKILKIQKFIKNIYPQLQMYILIEFKRMIVNDNDKETLIFFQKNKGWEICFSDYFIRKNFNNLNIEENEKIKLNQMNSDLQTLLIDFMFNVLLKYQEDFDYKFLFNQISKNQNIKSNLFLLNRFLKMITELIKKNHQISSNKIIQVEGFREIQKILFHSIQKNQNQNQTINLCLEILDLLLQNSNIKIIFQNEEIANILIKLFENKITQQISLIHIPKIIEKTKNSKGKNENQFISYLFQKILFLIQKIISNQNQEKSNEIEFNDVKKLFSKCSKSISKNREVIQKIILNSKLLFIFRTLLNEKEQKSTHLILTFLKELIRNNEVMVYEFHQLIPQSEFIKLLYETEKGKPTKKLFEILLDLMINNGKFSIENNYIIRNKNMINIILGTYSQNQNENQNENNNNNNQIIEFIEYEFNEVLEIFNQICEKSIHNIYCCCEKGIISFLFELILKIQNLNLFKKIIQFIGKLGTHQFLVSEMKQYFSILKHKLRKRKRNQFAKLMLIELRKMINQNQNQNQNQNSINFYDFYQENSNIKLPSFKNDLISKKFSFVTWIRIEDFQINNISLSNENDYKNKIFSFLTKNSKGIELFLEFNKENKKPKSFIYKFNSNQENQIIQTKFPFEIEIKKWYFFVFTQKYNKSNSELEITIYLDGNQQKTKKILIKKIGIEKQPFIKNEIGSNFIFSNQNQKTKTRIKSFYGQMGTIYIFKEFLNENQIKAIQFLGANYNSFFYQNETFKYSNSNPKIEKELKEILNGKLTQKIIIYHNPKETKENLCLNQNQTNINKEYSKIGNIYSFTRTKIQDIIHCLGRIETFFYLILEIDELFQEEEFNKNKSKIFHIVNENSSERSFSVEKEISTSDDTEKEIEIEIEIEKDKDIEIENISQISLDIENVNDNDIENENNTKLLFEEILKIIQDILLNDLFFQEEMIQKQKFPIFGLILKSIHSKYFSNQIYHLIKKLKEKIQNEKFQIQLKNHLIFDYQIWRNFNFEIQKKIISKNENENEIENEIENEIENQNQNITIFDLLIILNYYDESLNKIQKSNSSIHYSNFRNQIDELSQNLFSIIEILFDQIGNDISKLEYIKSLISSCLISKTQYFIGKTLEIIYQIIKKNPKLNLKKPFSVELFKSLIQLMKENKKNTKIIELCLEVIHFIDIYLNENQEEDQETNQNLKKKKRFEMNKLKDFYPLIHNILIDNINQITKGIIDILFKMMIYGNINDKSKITFIQNPFILETICEIFNHLPKLFDIINFNKIFVLIAENNLNKEKILSETEWQKWLNYLINFNYLQQKEDQNENENENENENENQKYVNEIIFNIFKLMFIYCFHHPSYNFPEIFEKFLSSVYLVHFSSTNKETIPKIIKRIINDIFEDLNRNSNQEIDNNDNTRYFITSISTITNIPKEDFFKNLFYLIKVLNGTVFILSKNEFQFSIIEIQNQNQFIQTTISKHFTKILKTKKLNQNINLNNEINLNSILKVKHDLSAKTEILKNLILILEKFEFFKEKQIENKNKEETRTIYKMIIFLIFATIPTSDIKLTNFLISKLNEIINKLSNFKSTQIQNTQELIIICFSFLFSYIQNENNQNENENQRKAKRKLFLSNLKMIILENYDFLFNLFSNQNKKQNLLNRNPKNSFVLTCKNIEEFEEEVMKEKWKKAVKIFFSPINGKILRDIEENEKEFIKIQSNNIAFLKKIFLQEFKIKQKEVVLISNKIEKQKQNIVLKENKRRLKTEINQEENKMNSLKEFKKMIENSLNILDKESKKNQQQNYHLKLSEIEDELRRQKKIKFYSQKNDKQENKNKKNLIKLNQKIKNKMNEVSDQLSKIQNEKLKIKNNKLFITKCEIISKKEVTKGTIEITENSINFFDSQKDKEKNYLWEIEMIKSIHKRRYNFKHSALEIFLENRKCKFFNFSTIEKRNEVYEKIQNHKLTNIDLFKYNYSGNESTKWIEKTQITKKWQERKISNFSYLMYLNTISGRTYQDLSQYPIFPWIISDYECEKIDLSNPKIFRDLSRPIGILNSNIATYFEKHQLNRKEYEFDFQKFYSTAEIVSSYLIRLEPFTSICLKEKYSIFKSIPKTWKMIKETNNFIGELIPEFFHLPDFLRKPKILNKYENENENENEISNVELPKWAKTAEEFIQIHKEALESEYVSENINEWIDLIFGYKQGKQTKKSFNLFHTNSYEENTNFSNFKEEIKKEVQRKGQIPTQLFTKKHPKRFTKKEIEKQFSSSPFLFFEWKNILLVNKPLNFLRKRFTISSNPIIFTYYSEMIEVMMILGDFDKIITFDKERNIGKHKFSLIYSNQNFNQNSNSNQSYFNFQMEEKNEEKIPVSFSNDFNNFQECLSMDKNSKYIVCCGFYDNSFKIIDIENFKMTQSILKHIDIVTCSKIDWKYIVTGSRDTRVIVWEIDLKEGKVKENPKHIFFEHEKEVKSVAISIEYDIVLSGSIDGKLIFHSLNKGKLTQSIILSDKQPISNIKISKEGNIITFSENSNKLRLFTINGYLLKEVKCLQNIYSISITQDSNFIFLGGEKGTLEIRKLIDLKAIQKVDLKEKIYSISIIEKGFLIIGLGNGELNIGNFIENQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6N3</accession>
    <name>A0A9Q0R6N3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="812"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="945"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1409"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1455"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="846"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5068516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1617" mass="187328" checksum="BE8C3F0C6366AC3E" modified="2023-09-13" version="1">MRTEKPGLSQITLQNENQDSGDEIQENDLRSKILDMFNECGYADPFMLIMDTKDAVVREQCLEIICDLEWQHDQHPRKKLNSRICSENGYDMFHGQAIKYSLSVRSANLLFCMLLGRHPGSVLIDISPPQLVISENEDNSTFALTHLAEAFMIKKICVLETIGEALAKEGKTELARAIIQRFENIVTNSFVNQCAFSKFSNWERWFIPLLDPITSADQMRQKPKLTNIEPISRLPVLLLKDLNTSVFGIFSEIWGYLFQNEKGGWRLFDQSVKLALSMQYRKLSHEHALLSRMFSVAIDSFLKIMYTKYVNQSFLFVRAHFKESTTFFDNLLHFVILCNDFLVFVPTAINIPRIPSPIIRSRNLFGMGNEDDEKSPVVENEQNAREIVSEHKKEPTQTGPHVLSRPYGDVTFSYSLRIQDNKWKDTTLVLKLISFLDQFDFFNIQTASSVFVDKHLASTTLCNLALLLVSGITRLKGIETKWFVEKLVKFVSNVESQTANIKTRDRNIILIILSHLFEASENEQKSRQNSNTSDSNTDQDRPLQVAQSIMKKTYSILVPLMKDNSGRTLLPKKRAGSIIFHKSQDELREMFFGNTEWKDAIQNSFHSEAEKHRKQLDLQSTNTASEMRERLRDVEISQKKYLIQKVSSFENLLQKFRLDWFSSFKSFINEQIISSAAKRERKMILSMDQWRRTLRSLASERGPWGARKTLFESTFWKLDKTEDNERRRRKMKQNYHFSNHFDASVRRDQSSKEMADKIITQNYDKIQLQKLSSQPNNDTQHLHLLDIQRHTSDIPEEDPDALPDQNDDSEPTNSNKLVFQANSFLVKPQSSTSGMFEITRSEIHFYPGKSAPQENHKRPTTPTESSDISPPNNTSHGDIQKDRTWRLKDLKSIFKKRFKMKNSALEFYFTDRTSYFFDFTPKTRNIIFRKINALKPPNLIRVDTGAPTEWLRKTNLTKRWQRYQITNFDYLVELNFLAGRSYNDLSQYPVFPWILSDYDSDKLDLQNPNSFRDLSKPIGSINENNLQQCIARYQTFEKANTGVPPFYYGSHYSTPAVVLHYLVRLEPFTTLFIDFQSGRFDSSDRMFHSVSELWKSCTGTTSDVRELIPEFFYFPEFLENSNRFDLGKRQNETQVDHVVLPNWATSPEDFIHKHRSALECEYVSQHIHEWIDLIFGFKQRGEEAIKAYNVFYYLTYPDSVDIDLIQNQTEKESIEMQIQNFGQTPTQVFKKPHPHRLSFAEQQNIHPLYWKITRFSSVVSNIIKITDSPILFIANSSRLVIFDAQRNLTTYRWCSTNPVVNSSENSTTSFAINKDENNPPKNNEIIPQINEQIKPSIQQSQSQQNSLIELDSAMKNTRRKVGVSFSFMLPKNNRRFAISTNEKIIFSCGYWDNSFKLNQLDTTKLVQSIEYHKDVVTCLSFHKNTLVTGSRDTTVAVWRFSSKTNTVNEKPRHVLFGHDDNVTCVDVNEDLDIIISASQDGSCIMHTLRRGRYVRTIRVDPQTDVPISSVYITAVGDVIIYCEKSSTLWLFSINGKNLLSIRLNSSVRSFLFTQNGDFAFCGMENGAIHILRISDLKIIQSLFFHSPVLSLSFSQDEKQIVAGFADGMLLILFFMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R821</accession>
    <name>A0A9Q0R821_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptobrevin family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R821"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="562"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1176" mass="136732" checksum="C8CC40F02244C2FC" modified="2023-09-13" version="1">MIHLESIQNNLAVSTSLVIISTIFATGKKYIEEIYKLSNKSPKSLAVGFITLAYYFSGTTFKLAKDYSGNQTLDIFLRSCFLFGAITMGFGPFLVLTPTKQIILKKENIFKRFVEFSQKIHFLYNIHHYHNHANLCFVFSLWYTLDIILAVDLKITIGACVGYALVCLFYLTIFYSVMMKKEVRICGINLREQLRSRIYFRTKNGTKIMILDSKWYLIGYIVLFIAMLILSIVAISFLSKLQYQKMDQESSLNKSIFAIFLLMNISAIITFAGFILNVAFHPVTRTEMLTNDGKIVDLNTFKYFAIARSFDRTILAKFPAQNDPHQWAIDIVIQNEVKSSSNKPGFQKFMKCTEYSLFQQNDSYSMLFLATGPLFNPELSFHLLNNCFFQLNQQVYNHNTLLSFNLLHPNSLFKNVHNFLPILITKFFDKNNYQNLLLEARNSVNLLQKIFQKKKQIDSSLSNFKKNFNNVSDSPISFPEKLSSTSDISKILEAQNKLIRDQDAELDKINESILRMKSISLSITEESLQHSYLLSEQTEEIGRSVLNELAAQRDQILSIDNSTKKTQRRVNEAKSTIHRNIEKSLSREEKLEVLIDKSEDLAKSANFFRKSSRSLKTKRLGTKIGKSFFQSKKKPKTTKNQVSQKKYNLLDEDQDEDQAQVKKPEPSFDKGPKYYQMKDGDFFGKDEDENFKQIHFEFDYDHLREEKRKTHILKPEVIMKKKAKEGISSRIAFPNQKFVYSTQKSKIQFIQSKRTKIINQVVGSLYKSQMEMYADNKIPFDIWQRSNEGIQVFNPIFEFEMEDFMVQFTKKNTVIIPKSIGSNFLTIYSMFPFPDKGIHIWEMNITQNHQFTHNIAIGISRKNKTPNIVGEMKGSCGIRDDGHSIVYNKTIPFCPQFSKPRSSIFIIYNASRDSMEVIIDGKYYGVVCSHLSRSKPLFPCITFFHEFTKIEFPQHDPRLFHIRFSLFQSKLLSPFVSQPTLKYVEKYSNDLKNLNFKFSYDLKSFEFKSIRVLTFFNFQVDGFVEKLFLSIEPLNVFDLFYILDCYSIAKRKLLFLLSSVENKSLNEISNKNFQSKNQKFVSIISRLLDMQKDWITSQTIEIAMLIVKNGLNDILPDAKELGDSNLMDLISGFRKIYYVLSDNYLNLDLNLNLNLNFGFDPNGRKINEIWYLNKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8Q4</accession>
    <name>A0A9Q0R8Q4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alphabet isoform e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_10718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8Q4"/>
    <dbReference type="OMA" id="ATEIPAC"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="371" mass="41853" checksum="3BE4495B58532DE3" modified="2023-09-13" version="1">MIFEKRDNLTSVKMAAVSADPNYRFRRAMEDTYTIIDRFGGQEGWGFFAVYDGHGGSQVAQSAQKELHKVFFKCIQNSFQDDDDNTLLNQVQINKEFQNENQMNSNDNKNSVNDNKNLNENKEIPEKKPIEKDNKKQNEAESDIDDSDSDSGESETEVETEVETDPEIEVNSVFTESFAKTIEEIDVSTLQINRVFAKCYSEFDGLIPKNNGLNTGATAVTCFIMKHRGKRMLFTANIGDSRAILVRENKPVMLTFDHKPTVKEEEERVSKAGGFISSNRILGLLAVSRSFGDFSMKEFVSHEPFTTEFELTEQDKILIIACDGIWDVITNDQAVELIKDLKDASQMSKTLLNHAIKSGSTDNITCMVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9I8</accession>
    <name>A0A9Q0R9I8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9I8"/>
    <dbReference type="OrthoDB" id="17995at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="723" mass="82501" checksum="2360EABC25AD3E8C" modified="2023-09-13" version="1">MNKEVNEKIRLPEDITGQILKGDAQIKMPNKALFEIINEIEERKNGGITLKKANYEGISNKKAAKFSSQFEIEVLSQNQWSKLELLPTTVALTGHTITNSVGKTAWIASRGSRFIFLANQKGLYKVNMEFSVKYETSQEKSISFRIPQSQTSNVQFSVSGNVDIYAQSSINSDLVRQEKQTLLKTSLISSCSYLKINWSELKVENLRDRENKLDEDKEKEKEKAKFIVNSEQFLFFTIGEGVVITDATFRYQILNGNRGKFEIEIPNDVKIVSVTGANIIKWKKLGKKESRRKKKEELLDLEKDEKEEKNLKGEKFENSEKLTGNYLLRVTLQFPVEGSFYLSVVAESPISTSSGKVCLPAFVSREVNREKGWIGVDGLPNYEINEIEMNSITKIDVKELPTELKQKSPQQIMLFAYKFLVPEYGVEFDVHQHNETDVLVAVIDEMHIKVSYSGSIFIYQCSLNMRNTQKQFLRIKIIDPKFQLWSTCVSGSPVKPSFDNQDKCIMVPLEKQTENSDSFLLDFVYISLTPQMKSRGNFQINFPLMDLPINQLFITLYLPKNYKYSEFSGSIPEVTNFSSISSSILRPTPITTTTSTITARNAPQLFGKKMPQSNIKMNFFMNDEENEDFEIAQEQFFGTTKGASNLGVMPVQISEVVSGLSFFFEKFLIPVTENNEVLKVSYLATSKGFFEKRRVSKFPIVSAIFGIISLVVFYLWFLITGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9J8</accession>
    <name>A0A9Q0R9J8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9J8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="401"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="581" mass="69329" checksum="DE1AA9812F8C4282" modified="2023-09-13" version="1">MDNNNNNNQIENANQNQNEIEMKNLQKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNEKLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDIFPKSFLVDIQNKVIQDNQKENQQMKIEIEKKWKKEVENKEKENQQMKIEIEDKNKEIEKNQKEIEDKKKENQQMKAEIEEKWKKEVDDLKEENQDMKPIFDKYREQYQKDLELEKKLEEIRKNFPQFSGIVKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGFKHSTNGELSNDSNAFIFSLRNDKGDRIPAKFTCKEPQYAIYSHYTYNGPVFGYGNGTDFCLYSDFHQPGLSNFGSRYNLPNGITYDTNEAKSYLAGSYNSWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAK3</accession>
    <name>A0A9Q0RAK3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dual specificity protein phosphatase -related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAK3"/>
    <dbReference type="OMA" id="CAYLMWK"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="158" mass="17945" checksum="01E1796DAE1D4D7D" modified="2023-09-13" version="1">MINNYNSFLQTDDLPQKIFNGLFIGSIDASENFKALKENEITHILQLFYSNKPPYPNDFKYLILDMQDSSQEDLSKFLPKCFEFYDSAQNSQGNLLVHCVAGVSRSGAVSTAIVMRELGLGFDQAFDLVKSKRPVIHPNVGFSQQLNHWGFKEAMKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAZ0</accession>
    <name>A0A9Q0RAZ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cullin-4b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAZ0"/>
    <dbReference type="OMA" id="FGMGEDM"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="309"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="661" mass="79680" checksum="28DF12DEEC690CD1" modified="2023-09-13" version="1">MQIFSQIKKRIIQKITLYIQTEMNELMKNKEEPKIFIQKINTFHIDFNQKLINLENAFGKFYQTKTNSKQFISIEKFGDYFLSKLISESSTFSKRIISEFIEFFNQIRNREFLDENLIENIINLFNESSELQKEFQTKFIEKTRNFYSSRIQEKKLQLNMMEFTTFIDDKINEEMERMQKIKSNDEQFIRLFGQNLQEMFFLENKPQLLEQGFQKMLETRNIKLIAILYLLFKRANLAMELYRDLGKYIQKVGENIINSIENKKIIIARIIDLKDYCEQILNQCFESTQECKNVIHQSFQHFLNLKEDLTPELLAMEFHKILQIQRKDFFEIEFEHKIDKLIQIANWINAKDIFEIVYHKLLSKRLLEKKSSSLRMEKYVVKKFSSNFETKIVRQIDLMLNDLESSEENMKTFKQRIKNDDFKFKTNINILTHSNWPNFKPVKLKIPKEFGKIQDSFLDFYSQLHSGRKLFWHHGLSQCIFRINFESFQKEFIAQFPLAVILLLYENADCLTFQEIQDQTEIEEEELTQFLATLCFGNARILIKEPNSHKIQKSDKFIFNNNFQHDLYRIRISSIRIKKNLEENKELKEKVMKERNYVIDAAAVRIMKAEKTLTHEMLISKILNQIKFQIQVSFIEKRIKSLIDREFMIKDEKNPNLYHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB48</accession>
    <name>A0A9Q0RB48_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tpr domain protein in aerotolerance operon batb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB48"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="150" mass="17944" checksum="C2752848F1478779" modified="2023-09-13" version="1">MQKENQTKDQFNSKISLETWFSQFCFMILIKNSGKKQVKRFEQILNNIRVTLFPNSDFNSIPKHEETLDILLYLIKNKINFSLITDSKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQKNQNQNQNQNQNQNENQKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB53</accession>
    <name>A0A9Q0RB53_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB53"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="140"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="307"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="384" mass="45478" checksum="3B210B6382165242" modified="2023-09-13" version="1">MMKNVSKIFSGDTSSCVFLLNSIQELFGCGFNYHGQLGLGESRKETNIHKLTKIQNIPKGKIIDIQTSYYQSIMLIENENQDQNPKRKLYSCGYFPYNGLGKYRNTYEFTEIKSFLFENDDDILDFSVGYYHNLILTSNSKLIGFGSNYYGQLGTGDTKDHKVPIQIELPKLRFNENIYNYHISCGYHKSFLYYSPFSPFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEIIYSNRIINPILYFEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVADYSELSNKSFQIFEYWIYSNQIKDEIQIIFQNQINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC08</accession>
    <name>A0A9Q0RC08_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyadenylate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC08"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="130"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="222"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="533" mass="61854" checksum="1F757A931E268B37" modified="2023-09-13" version="1">MDTQNQPQPQPQNQPQAQNQPQQQLAQNQNQPQAQPQAQPQAQPQAQPQQQPQQQPQPQQQPQQQLAQTSTLHVGNLPENVTDQLLLQLFASFNPNAEDARENYDGGEYNGHILRVTPKIPINKLKSGKNNVIVKGLKKDWFEADLREILSKKISNCDIISIKVPRTQNKESKGYGMANFASEEQAREALKLTGEVIEGQPIEVEPYLDSEFRDEQSKKTYKRIYIKKFPENYSQEDLQNLFQQFGKIDKIELSRFGKAQIPYAFIDFSKHEEAELAIEKMNGKRIGVQEIYVGRAMKKAERNRFLAQQRMRRPGLIRTNNIKFVFIDNEKIMMFDSATIREECLKIEPKPQIFSSKVFYSKDTGKPSTGFVCFETTFDCERILRFFQQNPKPDYQVTKHEPNMHPNPQPRGGYYTRPPPHFNPYSQGYPPNQPYQNPPNPQYPPNQYPPNQYPPNPQNRGFAFNQQINQQPPIKNPHPNPRSFSPNQNPNPNYQPRPYQNYQPRSNYSNQNRGRQTPRNPPHNMPNINPNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCL0</accession>
    <name>A0A9Q0RCL0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipopolysaccharide assembly protein b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCL0"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="629" mass="75420" checksum="A456554FE2E7406C" modified="2023-09-13" version="1">MQNKEIIRNSVKLLFKYGNNKKRKNKTILSLEKIKNELFPFENWGTNFHVHFYLGKLYFEKFKTKEENCSKSKENFILELKHNPKSFESCFYLSKINFFQSNYEESRKYCEKAIEMKENNIPINLLLSSIYLKIGANENLYQALELAKKAFNLSKSQPKIEMRRKCVFLIAQIYYKQQDSVNFQNWCDENFDFSNPGDCFVYSLYNFQYGNYQQIEKYLKSFLNLSSFTNKYSKKREELSRKRRDLANFLLVIMEKRKQNFQKAIKRVNQIKQRETYKLRINIQLGDIYFLQNDFDNAKKYFLESLQNLSDNSLKYNVLFRLACIFKQMGNNQEVLNVLSEVKIENISDDELLFQFGLLYKEMNNIKDAIFCLEKVIQQNGKKLETYICLGNILEKKYLWKQYRYLVSYFLENVEVEDPDQHLSLKKIPYFGIHPSMFINQNTKLTEQYVNLVNKIKSLDRTKWNVHGLFLFNNYITIVTENFKNTQPLNEEIKISLNSVDLMEISVLIAGNLNRLLDMDWAHGNLDIHDILFFPQFFNRKLSHFELNFSKSLGLRNFQTENNLNNSKKADLKWFEQVFLILSQKTSRKPKFINDIIQEFRKPESSVENIIKILKEILWKEYKIRIRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDQ0</accession>
    <name>A0A9Q0RDQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDQ0"/>
    <dbReference type="OMA" id="NINYREG"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="324" mass="37266" checksum="F9B3AE12CC10F0AE" modified="2023-09-13" version="1">MNIWEAFQQLDFEILYKIEKIPKKQLEKEGETILNFAIEQQAPLEIIEILIKKKANPNSINHFGRNALHIAIINSAGIDIIDCLLNSGVSINQQDQKSKTAFHYSIIYLEKPSRIGVIKYLIEKNADIFAKTKFEETALHFACKKKSLKVIKLLIEEGLDVNSKTIYNESPLHFACQWSSLEIIEYLIQIGADVFEKTNFFETVLHFACRSNSLQIVKYLVEKGVDLNARTFKNETVLHFVCRSNSLQIVKYLVEKGVDLNTRTFNNETVLHFACRSNSLQIVKYLVEKGVDLNGRTFKNETVLHFACRSNSLDVIQFLIEKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDR7</accession>
    <name>A0A9Q0RDR7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26s proteasome non-atpase regulatory subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDR7"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="225"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="438" mass="50690" checksum="1F67226B70F4D9DA" modified="2023-09-13" version="1">MISLKEKYQKAKQNKNEKEILKEYQEIIQTKTENEEEIKIKEETIIEIGEIFAKLGFGENIKNLMDSLQDFFLQLPKARTAKIVRKLIELINQIPNSIDLQIHVCSHWIDWAKKEKRSYLRQRLESKLASLYLENTNFQMALTTITNLAKEVKKLDDKLLLIEVNLIETKIHIELKNIPKAKASLTSARTSANAVYCPPLLQSEMDKLSGILHIHEQDFKTAFSYFFESFEGYSTIVLDPKLKKKYSDNIVGQTKFKFIEKEAISTLKYMLLTKIMMEHPEEIHGIVNGKVASKFTGREIDCIVKISEAYSERSLHKFNEAIKEYDKELQEDPIIKNLLNSLYETMLEQNLLRLIEPFSRVEISHIADLIKLDTKTVETKLSQMILDKKFEGILDQGAGCLIIYDETIPDETYKLSIEIMENLNVVIGSLYQKAKGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REC5</accession>
    <name>A0A9Q0REC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inner membrane protein yaah</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REC5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047623">
        <property type="entry name" value="SatP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178:SF3">
        <property type="entry name" value="SUCCINATE-ACETATE_PROTON SYMPORTER SATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="299" mass="33784" checksum="3EA45CBC3050FB22" modified="2023-09-13" version="1">MTDSEQTQWEDIESEFENKKSKEEKESDIQTDDFQENNMITETEDTLEVEDKDTDKDDSIISSKNQILVKQIFSEVSENDSESEFSDRGISTKIDDVLPGQEFGPTQLGYMGLSLGAAVISFSNFGVSGSAVFEAQGLLFIPSILLLIAALLNLKNNDTLEASMFILYSLLWSGLASSWSSKLWDNSSRLVDGEMRIMGAFLVGFLFFSFFFMLFSLQVNKVVFFTIFSLDLAIFFLIFRLIYGSPAVLAGVPFFMVAILSFYISISYVLNGLIGKEVFEMGDPIYNWSNFHFNFKFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RED8</accession>
    <name>A0A9Q0RED8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor gte8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RED8"/>
    <dbReference type="OMA" id="NYCETIN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="302" mass="35185" checksum="DCD1C836C696B162" modified="2023-09-13" version="1">MQNNLSNNQIEKKNNTQNNRTIANQTLKINYKEKNEQKILKENQYCLKLINNLNSLPSFQIFFNQENQENQENSNQIQFNEISQKLKNNRYLNIQHFFHDFISLIENIIQKNSEIFQIKKNALQLKEIFKKNFQKMIEEIKSNEEDEKEELKKNEIHEILKESLNENENESESESSNSNSSNSNSYSETESDSNNSSNSNSYSETESESNSESNSESNSDSNSESNSDSNSESNSDSESDSESDIEEKSQFNKNRLSKNQNQLNQNQNQLNQNQNQNQYQNQIKSIKSIKSIKSIKPKQISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RES4</accession>
    <name>A0A9Q0RES4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RES4"/>
    <dbReference type="OMA" id="AMAYKME"/>
    <dbReference type="OrthoDB" id="2359033at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="471" mass="56375" checksum="A24CA933211DC234" modified="2023-09-13" version="1">MTNYLNLEKLSNDLKNLFQNQKEKESYFDFKIICEQNQISFKTHKSILSSRSDYFKSLFKSKMKEYQENKLILKDVSSSILSSILNYFYSGKIEINLENAVQILIFSSKYLIDDLIGICLNFIKNHLQFETVVDILKLSESMNFNQLLDSSYKFISKNFDKFIETPFFLELEENHLNYILSNYEILTDEFELFESIIKWGKHKSNINQEKELNKEEKEKIQDQISNVIEKIRFIDFTKKEFEKTLKEELIPKQISEKLIQFQKLQNQENEKELNQFIGKELKEFIEKENENENSFIFKPKIGLSCSTIIQEKEHFNKLKEWINDNEFFYRMRLGFSAKKDGFNCFKWHKKFGFINNEIYWSKNLEEAGYISDENAFLFSLRNDKNDRKPEKFPVKYMKNRTALYYQDDIGPTFGKFSSDLFLDEKLKTGWTSFGRSYKLPYGIKYGTKEAEDYLAGSYDQWEVEELETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF69</accession>
    <name>A0A9Q0RF69_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Esophageal cancer associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF69"/>
    <dbReference type="OMA" id="XGISECL"/>
    <dbReference type="OrthoDB" id="1734063at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="ESOPHAGEAL CANCER ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673:SF0">
        <property type="entry name" value="VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DED" evidence="7">
        <location>
            <begin position="890"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="993" mass="114938" checksum="426B7A849270747A" modified="2023-09-13" version="1">MNEENIQITPIQRNYETEKRNNLIPLQIAFNHPLETIKTVIIEPKKKSKRKSKRKSKSKKKSKEENPLEEDPLTKSEEYDPLTTNIYENKQKYNPYMTSGMLLSNTSLSITETSGQNFSLKDDFELQFVPWTVRKTSILAKYTTNSKISIQSKFKDDNDFGTDMQNKQTSLSQKVSRDNSDNLSQGKTKIERLKASEQEKEREKKLTLTQDEYLKYIQKITEELGQCWNNNDRVGALRYVIRAAKMLRNTSCLPFYPSQFFLLADLFDSFGDLVFDRLLDLTDAIDPLTGRKYPPLNRDFTIEQVPEPSKETARNWFYKIVSVREVLPRIYTEIAFLSCYKFFSNEELGDAIERLGKMIRGIGKPITALYCRAYLVKKAKELLPNKNDFIVDLFEDYLLSFKHQLLSERHTQYLQKKGLDFNKYIDLHKPAIEWIIQNIGLDGNNETFLKILSIFKENCQSSMIFEIILNSFRPSIISSNITQLIQIFQELDDSIPRYKLYVTLGRTLCITPPPKEKILKVLNEIWNVVSRFPEIHDYISVAEVFIEYPLKNCSTKHVDVMVKDILRHISKSGSKDIVLQIATITQKIIWFSPSLTAVLFSDNFTKLMNLITGDSKVELAKTIVNSLMKSSEFVSDPLILYSIFEQTKLLHDSITSLSTPEQIKEISQLISNFLEKTYFGNEVEKELNFLVECRETFLNLDSVIGCLVQRALLLTMKTFKIVKKKHTKKTTDFVKACLSYAYITIPSMNDYFLRLNLYLQAGEISLINSIVSQADTFFRAALTLFQELSTQKSSGDSNSVLIDEQKLIDFLRYFSSILLVVPGHPELGASYLIKAMIKVLKDFPWSQGSDAKIQIYFSLIMLFASLSQRNYIYHVPNIDSNDTLYAGDSEFLQELQGFSSILVQEVMNELYVLEKEMNPQSKKKNAILSLDFFNILIEHYVLDKQSAKLLLKLFENAKKSDYTDRIYLKNTLDSIQKKQDSIYQQLFSKLSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFC0</accession>
    <name>A0A9Q0RFC0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase-associated protein ctr9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFC0"/>
    <dbReference type="OMA" id="EHWLTIA"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="699"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="950"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="957"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1009"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1058" mass="124425" checksum="CC39CAD6676A2AA0" modified="2023-09-13" version="1">MDDLNNRVISIPLKENPSELVEISLDDLPEIDDLLDLLKNEAARLFLWLKLALEYYRQKQYQDFERILITAIHDRLFEGRGADDKDKHRILNALACFYVQLPSNRQNYHVYEDWNRRAIDYFGRADKIMSQEPETLIAKGFFQIRQNKIVEADNYFNSARKRNQNLIVAILGKGLTQFLMENYSESFSFFRQAIRRNPKCPPEVRLGLAYCYFKLEKFRMSLVAFQRVIELDPKNDAALCGLGVLAQRGYVDISEETPREPQEKVAMEYFAKAYKINPNNPMVLINLSDYYFYRGEQRKSQMLAQKAYHYTKNNKIKAESCYLVARSFHSERQFSLAKQYYQETLKIWVRHFPARFGLAQTLLHERDYSGAVQEFEKVRFHLPHNYETLKILGMLYIKQKKNEKAQECLEKVVQENHYDIEALHQLAILYEKTEREKSLKTYSKLKGLYEKWGIKIGVEIWNNIGTLRQIKGEIMKGANQRRGLEEESRTREAEKIYKEILEKHPSYVDCHLRLGVICEKVGDILEASRHYQKILSGDKENTSALIQLAYLHMKKGTQGDLKSAMGLLERARKDPRNKQRSGYVLVALGNLLRIQARSDPLRDITLANFDRQINKAMKLYKEALVLQPSNVYAAHGIALCLADKQRDDEARKIITEIHEASHNFPDARLTHAHFLLLDQKYTQAIKLYSACIRDSAPNAELLGCLGRAQLRAKTYTEASSTFQHLLRLDPRSRVGWWGLASVSRSHALSILPDKNPLEDRNLSPDDARLAEKLFQQSFRIFTYMRVHLDTQDAHDFLLSQEDQARAFITNAHKKFLDVQERFRLRQEEIISRRIRSENEKMEQLKIKQDLERKEIEKQKFYQQILIENQEKFQSLMNNPNNENKSGKDEGLYLENVDDESDNEFSKMFDEDNLDEDENLKENLKENLNENQNENQNENQNENQNENLNENQNENLKQKSKTKKSTKNKKMKKKKINKKNKTNKKNKKKTKKKPRTKKRKVISESEENQEEKQEENKQEENKQENKQEIEDIDDIDDIDDIDDIDDIEIEEIPNQENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFM4</accession>
    <name>A0A9Q0RFM4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFM4"/>
    <dbReference type="OrthoDB" id="203754at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037357">
        <property type="entry name" value="COMMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15666">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15666:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="181" mass="20845" checksum="F425AA8733014511" modified="2023-09-13" version="1">MTELSQTILDMISTSQTTDKQQFQNALKSVVSVLKNPTLSKPKHISLSLFAGLYDLFQMIEKQKISESGVRELLQKSNMQTKFINEIITVMNNIYQKQKEEPIHYPTLVDFSWRVDVIISTASLSRVLRPVIHLRMVLSDGSVKQFEMSMQNFQNLRFQTAKVISEMQTLEKSAIFKILDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFP6</accession>
    <name>A0A9Q0RFP6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Countin-like protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFP6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="430" mass="51146" checksum="375D9082146B0163" modified="2023-09-13" version="1">MIQVIDNYTNLIKKVSEFMLITKSTNLDESLAYLQQANWSLNDAVCVKALCSLRSKTTGIEINFSNKNLNFNKEEQTKEAEQETQIKFMEEQIKKNQTPLKGEDQRNYNLNQNYNLNQYYNPNQYYNLNQYYNPNQYYNPNQYYNPNQYYNLNQEYQENQGNQGNQEYKEYQEYQNQLNQINQLNQIQNEIQNQNQNGNQNQNQNQNQNQNQNQNQNQNQNQIQNQNQNQKITKSPTLTRKRKEGPNDDANSTVNRKDRQDGSKPISQNSTKTQVPKPKVKRPRATRKPAKSLKQILNGRKLDQETLQEFLTQKPAPRWKDRLNAFQKFNQNLISGFYLLRHKYRRSHQKKIKNRLRSLQESSGIPQLDSTDQEELWVDKKIFDFFPKANIEKKLKRNLQRGLVKYLISEGFDYRSGVQNGFLVFSKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFV7</accession>
    <name>A0A9Q0RFV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mtl1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFV7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="142" mass="17251" checksum="12068D9E19A61AEC" modified="2023-09-13" version="1">MSLQKKKKQSKFQEINLNENELENQNENQNQNENELENQNENELENENEIELENENENENENENENENENENENENENENENENENENEIENQNENENENQNEIENQNEIENQNEIENENENELENELENENENENENKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG68</accession>
    <name>A0A9Q0RG68_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_04542</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG68"/>
    <dbReference type="OMA" id="DYCNANC"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000905">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="12">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="114"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5078819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="391" mass="44075" checksum="DF1135C6C56C1AEC" modified="2023-09-13" version="1">MSNKEKKLFGKFRKKKKDIVISRPYNVTHDIHVDFNSETGFTGLPKQWESLLKTSGITKEEVHQNPDAVLDVLEFQNKPTMKGQKKQEAQPTNTTNVQRKLDTLISKEDPNQLFTGLKKIGEGSTGSVYVATHKATGKQVALKIMGEFIQQNMKVVENEIAMMRSSKHKNVVEYIGSYLTGDSLWVAMEYMDGGSLTEIVSICKMSEPQIAAVCKEILRALNYIHGLNRIHRDIKSDNVLLSTKGEVKLADFGYCAQLTDEVTKRNSVVGTPYWMAPELIRGQDYGVKVDIWSLGILMVEMAEGEPPYLDYPPLRALFLIATHGPPDLKEPDSWSSEFKDFMAKCLEKEVTSRATADQLLRHPFIRKACSLRGLIPLVHKAKENQTNLDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGV5</accession>
    <name>A0A9Q0RGV5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGV5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="141" mass="16945" checksum="F038C2AF597522EA" modified="2023-09-13" version="1">MIYSNNSKINPKLYSKIKEIINLNEKIEETIKRIYLNENENEKDFIIEKNEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSDKSFQIFEYWIYSNQIKKGIQITKEIIDEIQIGIDYFQLNQTNPNLIDLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHP3</accession>
    <name>A0A9Q0RHP3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myotubularin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHP3"/>
    <dbReference type="OrthoDB" id="2408718at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039802">
        <property type="entry name" value="MTMR14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524:SF2">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="247" mass="29122" checksum="13171BAF189D5F78" modified="2023-09-13" version="1">MKIKKIQIQNQNEKKEDKEDTSNFLLQKDGVMGEVRDADIALLKTFKVGYIMDLMVEKRKKKYGVYVCSSEKADSFERYKDFHINECPYPGVEIFSEFYNNKYCGKDLKFDWSSPSNTAKLSIDKTLLERLNSTELKNINYQDYQKWDIIDITLNYLKLLLLIVANPNNKDGILIHCVSGYDRTPFFVGLLRCSFWADGLIHQNLNVDEFLYLTISYDWLLEIKLEALFQRFKEIYNEIIIPLLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHW4</accession>
    <name>A0A9Q0RHW4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding region rnp-1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHW4"/>
    <dbReference type="OMA" id="KHEYKNE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="606" mass="71185" checksum="9BF719584D18872E" modified="2023-09-13" version="1">MKFKIKFKIINLISISICQKKEIEESDKTADNTPKLSKESKTTQKSKEIIEKETKHESKDKSKNETKHETKHETKHETKNEYKNESKNESKNESKNETKNETKNETKNESKNESKNESKNESKNETKNESKNEYKNESKNESKNESKNESKNESKNESKHKSKDKSKNESKNESKNESKNETKNKSKHETKDKSKNEYKNETKNETKNETKNETKNETKNETKNETKNEPKNESKNESKHESKNESKNESKHKSKDKSKNESKNESKNESKNETKNETKHESKNKSKNETKNETKNETKNESKNETKNETKNETKNEPKNEPKNESKHESKNKSKNESKNKSKNESKHKSKHESKHKSKDKSKNKSKNETKNKSKNETKNESKHKSKDKSKNETKNESKNESKNETKHESKDKSKNESKHKSKHKSKDKSKNESKNKSKHKSKDKSKNETKNETKNETKNETKNESKNKSKNESKNESKNESKNKSKNETKNKSKHKSKNEYKHKSKNETKNESKNEYKNETKNKSKNEYKNESKNESKNESKNESKNESKHEYKNETKNESKNESKNETKNETKNESKNETKNESKNESKNETKNETKNETKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHY6</accession>
    <name>A0A9Q0RHY6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000003">
        <property type="protein sequence ID" value="KAJ5080727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHY6"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="229" mass="26575" checksum="07070D3CBE3CF5A3" modified="2023-09-13" version="1">MNEELNSKLFKKSLEIIKYLIEKGADINLKEHNGELAFHYACKNPKSKIIEIAKLFLEKGIDINEKTTYEKIPLGLVCYFQTENIFEIIKFFIENGADVNLNRPYNDSPLQNVCQNNHVENLFDIFQYLLEKGADIDIKGVNKNTTLHYICDRSNCPNLFEIIKIVIEKGVDINARNTSQDTPLHYICKNEQTSNLFEIIKYFIEKGADINAQNNLKNTPFYYICGYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L533</accession>
    <name>A0A9Q0L533_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rhomboid-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_03549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L533"/>
    <dbReference type="OMA" id="ICSVIWF"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000008">
        <property type="entry name" value="RHOMBOID-like protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="48"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5066216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="226" mass="26993" checksum="4C0717BB69BE33F5" modified="2023-09-13" version="1">MSIIDEIKVFPFTSIIIVICCVVWFYLKEYNISFETVGLGYETIIYSGEFWRILTSHFSHSNIFHLIFNMTSFWELRFLENDKFNYFKNIFILIIGSSFLTLIIYHFLITKKGIDRYRNLYGIGYSCVVFGLQTQFFLNSPGDTFHFFNLLEIPSFFAPFFSLLFTQLIFPQASFIGHLSGILVGFLINFHCFFWMNYYLTFSAFFWFFLIVWISRDLSNRTRMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6K5</accession>
    <name>A0A9Q0L6K5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6K5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="135" mass="16346" checksum="29EA13D5569D3613" modified="2023-09-13" version="1">MTIKLHVNDFISARNSFLRFLLFKKKQYLCDMSSRYGKKKSFFFSYCEPAGSNKDLKKFFSSPKYSSQLIYSLEMIIKVQSADLVQLFRFTIRFEKEEEKKCKNLKKKERIQTIKKRKKVNPKPKRNKRKNPFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L707</accession>
    <name>A0A9Q0L707_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger ccch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_12884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L707"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="8">
        <location>
            <begin position="57"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1004" mass="120274" checksum="91A981FFF2B6BB1B" modified="2023-09-13" version="1">MIASISRKKLQDNKITNEIISIIFHTIEFIEAINFEPLKKLISNEMMQNYEESSTINTMKELKEIYWIGMPGHPLLKEYLKGGRAWWKCKNNHVFYIGECAEPDEIGVCPVCNEKIGGTHHSPSNGTTRANEKDFPSPLGYLHSFYEIEDEQCRSNLKYDCYLILKIITNCVILCFSTINDHFANNFLNNIINPNMKKPKNIQELKEILKVKVEEDFILLAKILNLSIEDAYHFYHHFLNELGSDNKWKLISSENINEFKDENKRIEIEAFFGYQLQKKKQKILEIVKEKQGIEFKNAIKELNNYKTVYQSITYKRQTYQQFLSFFKEDVNEEIPKSPIIFFVIKNWKKLYSLSLFPGFLNFTSYVMETLNGKISKKDSENLTIEKFIKNEESKNKDKSNKIEKWYEDFEKFWNLTWKDVKGVFGCREIPNYLQQIEMSKNLPISFCLSGEEDVFICVPSLIKYAISMHNQLMGNKDIKYLFLIKQKKKNIEKKENNNNYNQIGTYEEEYRKHPELFKCKKKDNDNNKNNNNGFDPIDFIKDNPLYFSSKNTDNQDKEKEKEKEKEKEKDKDKHKHKHKHKHKDKDNQEKDKDKDKDKDKDKDKDKQDKHQHQHKHKYNQDKDKDKDKDKDKDKDKDKDKDKDKDKDKHKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDNQDKDKDNQDKHKDNQDKEKKKVKRLIDPFEKFTINFPLNYEEFDKSKIIHLNTEEVIDFINDHNIYQISVILLKEYLIDFLNITTKPKWIESKIEYFIFNDNFNQRLLRLNDQRWQQEKIPQQIWKEIIQELEETNAINQCMSLIQIVVFSCSNIPLDSVHLHNIPNLNFLEFAEKNLHLSRNNNLISTKNGSKTIQNLKLKHLVNLHLNFEEYFYEPREKISEKFKKEISEKEKKELNEMIEYFNLPILLSLWKKSLMKIEDCLNEKTEFKNFIIYIDPNDENEKQILDLIPRYFPKSILLKHSLSGYEFLLSKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L762</accession>
    <name>A0A9Q0L762_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spectrin beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NEFQQNE"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="132"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="965"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="814"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="965"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1292"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1387" mass="165748" checksum="C308502F50638F96" modified="2023-09-13" version="1">MDNKETSQKSIMNQAREEMQQKTFVRWIQFQLKSEDLKFESLEDGFQDGICLIRLLENLSQKKISGFKTNAKMKVLKVENLNIAIKFMKSIGIKTTICVEDILEKNMKMILGMVWSLIQFFAIYKIIFTNDYKPKDLILLWCKNCATKLKVSIDNFTTSFYDGIALCALIAVHHPELIDFTKIPNIETEKRVLKAFKAAELLGIPQLLDLDDFLHNRFDEKSLFTYISMIFRSLAKSADILNLINEFQKFSKRKSIGTSHSSSNLKGILQRKNLFISSILSPRMENFQFSNTKTNLTPNEKNDENIEQNIYDGDVIEMFTELRDTKTQLEQFKAEVALLKKEKQNIQNIQNIQNIDPNNSLENNQYLNDFENNSIQNDEKYNDINHQNFSEILNKFSIEKQELLNRIHELQENNENLSEFIKKITKKKIDKKKKKEELNQTEEFKNENQFLDQNIEKEKENNFKEKENDLKEKENQLKEKENQLKEKENKLNKKDIHLEKKHNHLKKKHKKLKERENQIEERENKFKEKENQLLKENKIEEQENQLLKENQMKERENKIKEKENKIEERENQIKERENKIKEKENKIKERQNKIKERENKIEERQNEIEENQIEERENKMKENKIEENRIEERENKIKERENQIKEKENQIKENENQIKEKENKIKERENQIKEKENQIKEKENQIKEKENQIKEKENQIKERENQMKEKENQIKENENQMKEKENQIKERENKIKEKENQIKENEFQQNEFQQNEFQQDEFEKNEFEKDEFEKDEFEKNEFEKNELKKNELQEKENKLKKYKKHLKKKRKQLKERENQIQERENKIKEKEKENHIEEQINITQEINQEINIPLEKELNNIRKENESLKSLVEEIRKNSAQKEQNFQKERDSFEKTIEEYEEKIEKTLESLSKERSKITQIKNKNKILEEKLKESINEKAKINEQNNELKKEMEKMEKMEKMKNSDNIQNNNNNTQTSLREPKRETHARKKSVNINEETRAPQQINEIASLRRSFKKQLQIQSRKTEQALAALRQLRVILQEKNKRIELGEQEIADLNFRTQSYQKRHQMEIMILEEELEKYKSQAKNSQRINSSLVREAEENIANFHSQIEFLKERVDDLRSLQESSKKKTGKKNESTLTKILTSFSMHLDNEQSRYSFTQLQSDYNTLSRLLNSKIEEIVSLKKQLSQSTETIESLQLLVSRLEQQKEELKQQIELAPFSQNPKQKPVENPLLNSISHSHSINSNISSLAIQKNPKTSSLSVQKNPKISVQRFATLRPSMSMSFFSKVPNSNPNSNSNSNSNSNSNLNNSINPEILNFVENLQNHSEEQIESEESIDSNKKFEEFIANSQNSEIVKDLNTKINTLTQDESFLISELSRLDKLVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L764</accession>
    <name>A0A9Q0L764_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein required for hyphal anastomosis ham-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L764"/>
    <dbReference type="OMA" id="FGEMQAY"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="305"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="462"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="684" mass="81805" checksum="CD0105383E1D5021" modified="2023-09-13" version="1">MSKNDADLEYNFDWKVLSNTPKKIEKPKYIKFKYQDKDTKSQEIGDILSYLEKKEIQTFFYSIFSKFMNEYFFPKKFWTELSTKEQTNFIEICLEKLEMNSKEQRRESLICLNIISFGLFLSHDDPQVENSESKINHPVNLESIEWNNRLIRECDGLQILLNTFILISSQFSSTEKNLDKFLVSSPIDLRLVLNLILVLIEIYSNDKEFEDELIFFKFEGDGIIQRLFRLISDSNDKPERCYPIKKIILFLWKMLLIHNKTLCSRNTELNPSLEPKATQQEFDKYHQYIQDKFSTFLPRSKNGIPTSFIDGEEVFKKAIEIRNQKPKYEDLKMNKFAKLIKHEFKNFRRYLILLLKILLASMPFQGYEVQFKIDSEVHSNSEELDQIVREVDYKRNKEIIMKATSAILLLLLKLSKKFDLLQFEYFNEVFVDSNCVLMILKLLNIELQTFLESETISPNDELINIEETILKKEMEIENENENENEKEKENDLIKNKHLNFRNTFATINLIRILQKMIKKKEFRIKNIFVKKKGHIILRKTLNIRIKVLRFYALKAIKNSIRYLTQKWKSSNINIISDIYTNLRNELAENWIEVQDQESISSETLRLEEERLRNQISEFIEKFETKDSEMEKIARLEFQFTNEPQNIEEELDSVEVPNDFEDNFSEWLQDEVYPHSFFFQNSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7D4</accession>
    <name>A0A9Q0L7D4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7D4"/>
    <dbReference type="OrthoDB" id="239701at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="393"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="483"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69941" checksum="7FB0ED0DF4E2D5CB" modified="2023-09-13" version="1">MNEILFWGENEYPKILKHEPKIIKKPIQFKFENENENENEKQIKQISSSNSSTIFLFENGKAIEYLKYSKQNPEKIQIENIQKVTVCCEDETILTKEGNVFAKGYDINPKKSPKEFINISSLIEDTNDRIIEDIASGFKTIYLLTSNHNAYGIGSNHFGQLGFDSKTFKKTRKPILMMKNVSKIFSGNTSQFVFLLNSNQELFGCGYNAYGRLGLGESIREPKIQKLTKIQNIPKGKIIDIQCGNFHSIMLIENENENKNPKRKLYSCGYYECNGLGKNQEDTYEFTKIKSSLFENDNIIDFSVGYNHNLILTSNSKLIGFGNNKHGQLGTGNTKNKKIPIQIELPKLRFNEDISNYHVSCGSFHNSFLYYYPSSFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNENQIEKLQEIISKKSIKELNQIFEMIYSNRIINPKLYSEIKEIINLNERIEETMKRIYLNENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFEIFEYWIYSNQIKNGIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQNQKKENCFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9L2</accession>
    <name>A0A9Q0L9L2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="85"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="348"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1469" mass="172694" checksum="49BAA623D51AA34E" modified="2023-09-13" version="1">MQFINQNQNQNQNQNENQNENINQNENQNQIENINQNEIEIQIENENEIENENENQNQIQIENEIENEIENEIENEIENEIENEIENEIEKLIPEYLHEKYPKQPQKFNLQDKSKLIDLEDEGLKVIYTGLGRDDSEAASIRADNPILNTNGIFYYEMTIISAGEHGYIGIGLSAEKVPTNRMPGWDFYSFGYHGDDGKKFESHGRGTPYGPTYTTGDIIGCCLNCINKSVFYTKNGKDLPIAFRNVNLGVRLYPFVGFRSRGEILKANFGNAPFKFDIQHFISEQKKKIFLEIFSDSHFINLFGNELVLSHLINRGYSKTLQAFINQSKSFGHELPQISNIQNIKKSIENRKEIFQLILDGKIKQAISNLEQTYPSFLENQEDLLLALKAQEFIAEIQNDQLDVQSLILLGKDLNLLKQKIENEYICKEIKTKKENEPQTNQKRQRIKNEDEFENENENENENENENENENENENENENENENEFREQISSFLNIDMFNEMDARARRRSVNDNLRNRLEWRISNRFPHLPRNEHIIGRGGLDRISPRNERISHNRFSRGLAEREVEIERNRERELVLRRLRRTRERTTRRRDEFSRIFVPEREVLDVDSTSDSTSDTTSDTSSDSEDSFINTNSSSDSSSDSDNEFSNFTQSNYMMPNIRNRPQRRGFLIRRQVGITAINRRSRFPHLISRRVSRSPVRRVSRSPVRRVNRSPVRRVSRSPIRERSISPIRRVNRSPIRRVSRSPVRRVSRSPVRRVNRSPVRRVSRSPIRRVSISPVRRVSRSPIRRVSRSPVRRVSRSPVRRVSRSPVRRVSRSPIRRVSRSPIRRVSISPVRERSISPIRERSISSIFARRVSRSPIRRVSRSPIRRVSRSPIRRVSRSPIRERSISPVFVRRVSRSPIRRVSRSPIRRVSRSPVRRVSRSPVRRVSRSPVRRVSRSPIRRVSRSPVRRVSRSPIRRVSRSPIRRVSRSPIRRVSISPIRERSISPIRRVSISPPIRRVSISPIRERSISSIFSRRVSISPPIRRVSISPIRRVSRSPIRRVSRSPVRRVSRSPPIRRVSRSPIRRVSRSPVRRVSRSPIRRVSRSPPIRRVSRSPIRERSISPPIRERSISPPIRRVSRSPIRRVSRSPIRRVSRSPIRERSISPPIRERSISPPIRERSISPPIRERSISPPIRRVSRSPIRRVNRSPIRRVSRSPVRRVSRSPIRRVSRSPIRRVSISPPVRRVSRSPIRERSISPPIRERSISPPIRERSISPPIRERSISPPIRRVSRSPIRRVSRSPIRERSRSPIRERNRNRNRRNRNGHSYRNQNRNRTNINYNFLPDEEIIEPGFFNFAFQEPKNENKHLMNSEKEDKQKEDTHFKIANRELWKQYIQGTKIQRILSLLSYKDPLKSPLNYLFSQKEREIIANLTIELLLEFEKHPKSSLLEKMLKHFVFIKICSSLLNIDAGFVGLLNAREIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9Q2</accession>
    <name>A0A9Q0L9Q2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00609</name>
        <name evidence="1" type="ORF">M0811_02661</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9Q2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="350" mass="41009" checksum="EFF7BABCAD387197" modified="2023-09-13" version="1">MADSPNIIKTKTGVVISTPQRPPDTSPQAIKMRRERKNKILRTFQTTKQRLFSSITTQSKEQIARQEVEQIHKTQLKKLIAMLIEKTEEERAEYFDKQTAIINKTRNSDEKEEALYNILLLSSSKFTESWNLKLEKVLTSILPILKEKDFYLKLLVSDIIKNLTIYEKNILRNKFKFSTKDWINKIFRNCSNFDLEDDSYFIINQILASLATVFNQEQAVEAIIPFIKSDGNELNDFINFDEFQDIGEVNNKTKEEIQKDTFLLAVSLEFFSQLIPFLQNEFMISKVTLLFQQFNNLLHNTNVLIRKLTTTVIVNMHLQFGKEMVEHPIKSFPKHLISLINTYIKRAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9W4</accession>
    <name>A0A9Q0L9W4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid--coa ligase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9W4"/>
    <dbReference type="OMA" id="SHVYGLM"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="94"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="684" mass="78169" checksum="E9230A1D430D143A" modified="2023-09-13" version="1">MEKISQGKPSHTRGLFFPTEPRIIEQDGVLTTSFKYEENGEIVYSSPLAKYVSNTNWNPKITTLYENFEKSRFEFENRPIYGTRRFNQEKKEYEDYDWITYSEFANQRDIFGSGLLNIGVTKNTNLGIFAKNRLEWATAEQACYAFSIVSVPLYHTFGAENIQYILNNTNVKAIITETKHLPKISQICNNSKSLKIMIVLDDADKKFDKLEKNDDIQTIRDAGIQIYSFDDVMQAGKADMKKHDPQTKDDICSIIYTSGTTSLPKGVVYLHKHLISAITGFMYVGYEFCDEESYISYLPLSHIFERVLFGTMIAVGAKVGFFSGDLLKLFDEINLVKPTLFIGVPRVFMKLYDKIYPKTQEGSLIKKLLFNTALDQKVKALRKGESTFLWDKLVFSKTKQAFGGKINIIISGSAPLLPNHQEFFKAIFTRKFIQGWGMTETGAAGLVQVYEDDVTLGVVGSPVVCSEFKLMSLPDLNYTTEDKPNPRGELLVRGSNVFSEYYNNPQATKSSFTSDGWFMTGDIAEVLPNGAFKIIDRRKSIFKISQGEYVSPETLEGIYIRSQYVSQIMVYGNSSESYLVAVIVPDPENLKKFFSDNKLKESELDFNQLCQLEQTKKLILDDLEQLGRSEKRYGFELIRDLIIEPEPFTVENKFLTTTMKIRRQAILDSYKIRLNNLYSKSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9X9</accession>
    <name>A0A9Q0L9X9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug resistance protein mdtg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_12144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9X9"/>
    <dbReference type="OMA" id="ENWSIER"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="166"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="600" mass="66882" checksum="29C51320032A92AA" modified="2023-09-13" version="1">MNNRKIDTEDEIEIDSVVIPENYKSNNNTRTNLEKFTNYTSQSETVINLTTSFSTQKSMTGRNSINTSDGKTSNLNSNSNGNQEENGKEKEFDEKKISIQKGEENPKENQEENQEENSNENSNEKSNENQDPKKDPNLNQDPKKDPNLNQDPNKKVKKGDGVDKVAVFTVYFCLFLAVIAFSILIPIIPFYAYEHYHVNALKIGAIEATYSGTQFISSFILGILSDKKFGRKKLLVICLFGLMIGLFVTSFSRTIIELTLYRGLTGIFGGFISLTSAMIADLVPNEYRAKYMGYSGGMFGFALAIGPSIGSSLSQWGLKGVSYASAGLTFIGFLFALIFLKETYVVEKKLNFTQIVAIAEEVPVESLTFFKALWLLLKRPFLVRFQASLFFSNLGFTGIMIIYPLLCEKLQIGLDQSNIGYVYMMTGFTLLIVQGGAMSFLANKIHLQTMVYVMVPFGGAMIAVLPEAKTKSTDILVMFLISVSSAFRVPCLMALVSFTTKRTDKGIIMGIAQSSSALSRTIGPVVAGSIFDANYKLGFWISGALLILSGFMMLGPKIRFMKPKEEIELGEIKIEQGTLPEFEKRENYSQKEWFESSDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9Y6</accession>
    <name>A0A9Q0L9Y6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9Y6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="300" mass="34697" checksum="AF57C09C30993556" modified="2023-09-13" version="1">MTSTTKIYNTFSILNTKGLALGLMILLTLLYLAAGIITLIEMTKHLRFFLATTAHSQTTKKIRGFRVVILFISAWFMIHQGCISMFGFSSNHLYVLFIVAYAIPFYLQFCSYILLTWLLGIIRYATISNQKAIKKVLNPIFIVVLIISFGLLLFSGNYYSNEKMQFVVSGFIFLLLVLFLGTSAYLFYRFITRLSMSFQSRSRVKIFMNLIIFNSTLFLLRAIYDFINVGTTKIIDWSTKDDNTFFPFYFVWMIIFEILPVVVLVLAFHMNISNEMGRKGSLTSINTRYHDIEDDEDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA68</accession>
    <name>A0A9Q0LA68_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ap-3 complex subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA68"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="163" mass="18855" checksum="4746EE027F0D32DE" modified="2023-09-13" version="1">MNKNKQLVLQNLTYNNLKEHLIKESLSKTETESEIEPDSDSELSLTSESESESESESESESIKKKINKLQSEKTIDIQSIMQTEKFLIFGLEVGKNFYISFWRFIWFLVVGCFGASFEFWIPDWYVDIINMSNVLKNALGSFIISATASIAQIKFQYTQTYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAA6</accession>
    <name>A0A9Q0LAA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAA6"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="749"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="661"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="844" mass="97626" checksum="781826377D3779E2" modified="2023-09-13" version="1">MNLIKKAIKENNKEYLKQIENISKQEIKKENKPILHFAIQNKVSKEIIEILISKGLNPNSVDELGRNSFHIAIINNSTNDILELLLSKGININSKTIKTKFLSIFQSGLKKVIQYIINNKIDIDTKEFIKETKIQIPSKYQNSILELIKYSDSHHIYINPNIFINKNALHIACKNENISIEIIKYLIENGININSKTEYNETALHFACENENISIQIIKYLIENGIDINSKTNDNETALHFACENKNISIEIIKYLIENGININSKTDQKETALHIACQNKNISIEIIKYLISKGIDINSKTDFSHVTALHIACYNENISIEIIKYLIENGIDINSKTNDNNETALHFACQNKNISIQIIKYLIENGIDINSKTKDNDETALHIACKNKNISIEIIKYLIENGIDINLKTEYNETFLHYACRNNISIEIIKYLIENGIDINSKTDDNRTALHYACLNKSNSIEIIKYLIENGIDINSKTELQETALHIACQNENISIEIIKYLIENGIDINSKTYRNKTALSISVENKKRELIKLLLMNDANIFDLKQNQITKEIIEFGMKIYSINQDLNNLLKSNEDNNFSDLQIQSNDGFKFNVHKLILLTRFDNNETNLNKFINICQSKKTKEEVEIALNFLYSGFYDFQQIYQKLNSENFEDQSKHYSNSNSNSNSDSDSNSYSNSDSNSYSNSDSDSDSDSDSNLFEEKMKEKENKIIKLFKEIGFDSKWIENKKGRKGIIKDLSKLYQQNETKDFTIIISKEKEIKVHKLILILRSELFKGMFLNVQDSSNQVHDYSKKSFKTIQQLIYFLYHDKFEFENEINEEFSDLKDYFQLNQNSIIDLLLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAW9</accession>
    <name>A0A9Q0LAW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein fam91a1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5069019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAW9"/>
    <dbReference type="OMA" id="HYESFPF"/>
    <dbReference type="OrthoDB" id="275996at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="4">
        <location>
            <begin position="410"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="845" mass="98033" checksum="3C5D370E15CA1CEC" modified="2023-09-13" version="1">MNLEQISKKQVEPAEIKRDWEYYIEHKCSWEKLPNSVQLKLGSNKLVYENYIRQYSIEHQLRWSDNLISKIGPNEETYYNSLIEYSIAHYMLYPYHISDVLIGGFRITPFKYYHRMMWKVMASEKPYDSIPNFTASDCVRILGIGRNQFIEIMNQCRGRSIWPFKKKNSQIKGLLPSVPSRPSSEAEPWWIVHLSSITDENLKNSSPNEKKTLEILSTNGPQLAKNIDFELLHILYSKGLVYFQVPIIETDYITIPPLKNFVMNRISNDYFEKLLYKIFIAYDERLNVRQIADLLGIDENIVKNAISIYCRLHFAKKKNPFNEKNLTKFHKSWSLKMKKIMKKSKSSKITQDSENENENTNTNTNTNKENNENVNETNSNNENDVFIKQSESEQSIAEKSDVDSKQQITSKRIAIFFDSSLPAFLMGNLTQGLKSHAVTLFEVGKITNDQIDLFLNELDKVDSAMEGEAKQYFEHAITLRETLRFFRNMNISFQNEDKTTTINGLDLIRSESVACLESDVLYKFLNRNYGVVFSIIPLTFEIGTTISLSNPIHFGAPIPEINSPWFRLFLYSRACSGPPSLFLIKGTRLKKLPKILSGYTKISIMGFNREVLTFTSGNILPHINDNLVASPILVQALESETSQYKELAVPFPLKEPTEEEMKMEIKESEYNESNMHLHPVLRKVQEELSLEKSLGIIIMIYVPKLHVVENFDENQNLNQKQGQKNQQKEFHWVPLDIQFGIPIFNTKHNAIITQKMKDTNFLSQENLQLHLRNMRILCLRFLKFISSFCEPESPFNFSPKKQKEQENIPESVSILGKIIPLPSKHVLFSKNKITSFSQSETLRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB73</accession>
    <name>A0A9Q0LB73_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB73"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="83" mass="10275" checksum="D9E3BD07F69FB86A" modified="2023-09-13" version="1">MVKSESIILKNASSSLFVIFIFRMFIFRLNFHFLCMDYFWAKGNDRLLAWRKYLNHSDNKVVISPWQDFCTHLRKWKNYRFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBG8</accession>
    <name>A0A9Q0LBG8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_12546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000119">
        <property type="protein sequence ID" value="KAJ5068210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBG8"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9428" checksum="04E8BF9A32D7E38D" modified="2023-09-13" version="1">MSFLFLKLFTKPQEMEIDWDCPCVKYLTEGPCGKIFKQSFECYTKSHSKPKGKECIDLFINLQTCLTKNASYYEKKKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBH3</accession>
    <name>A0A9Q0LBH3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBH3"/>
    <dbReference type="OMA" id="QGTNQHR"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="255" mass="30676" checksum="25EF2999AC40BA9D" modified="2023-09-13" version="1">MKVQSSFKNLVSEYYKNDNNDLSKYFLKLFLEDFKNITFNENEKNIYDKYYENDYEKFIDYFNDEKIDLIELSLKEIIQKIPIKELKQISQINNIFQFIQKLIPKIKSKTNEILNIIEFSKITIQNIKEFIDNENNNNNNNNENNDENDDENDDENDNENDNNNNNNDDENDNNENDNENNDENNDENNDENNDENNDENDDENDDENDDENDDENNDENDDENDDDNDDDNEKDKDKDKDKDKDKDKDKDKDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBP3</accession>
    <name>A0A9Q0LBP3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBP3"/>
    <dbReference type="OMA" id="YAKTHAW"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="1 4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="102" mass="11786" checksum="F56004F0EC562612" modified="2023-09-13" version="1">MSTQKQRKKKVQDPNNVIVKFIPTAGVPLTKITKFQIKKEWTIGQLSTWWRSKLKLDENQSLLFYIQQSFSPSLDETVENLYNCFQAGNILSISYALSVTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCK1</accession>
    <name>A0A9Q0LCK1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cathepsin l1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCK1"/>
    <dbReference type="OrthoDB" id="3789175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040246642" evidence="4">
        <location>
            <begin position="18"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="6">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="125"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="455" mass="50449" checksum="A4A16FA836C52C2F" modified="2023-09-13" version="1">MKFYLLYFLLILAFVFSSKVKLIEEETVTKTRQGKIKEDEFDIYIKSHNKNYGPEEYKARKQIYRENLERIKKHNEDSSQTWGAGENQFTDWSDGEFKAYLTKFPLPEFKNDPIDRSKLQPLTSLPDTYDLRNNITAVKNQGSCGACWAFSATAVAEGVFNLNDGILMDLSQQQVISCTTTCAGCDGGVTSYALDYIQVNGSCGDYLWGYEGQNGVCSGTSFDNCQANSFVKVKNQSTVFLYTDSDPVGLLQQILVSYGPVGIAIDADSLSYYEDGVATSMSCSNNPSNANHAPSLVGYGTDGTTPFWRVKNSWGTGWGENGFFRFERGINLCGIENYAYFATGSTNDGLTKFNDTVTGLKVSPSSNQFTLNWDSYPGAQKYFVKAIIDGELYLWETSKTSPTVDTASSYTNATCWVAPILDSQYGALSENITFNSAHSLVLSFLAFLLILLNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCZ0</accession>
    <name>A0A9Q0LCZ0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCZ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040115524" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="454"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="894" mass="100645" checksum="D891CF1D4FDC1B1C" modified="2023-09-13" version="1">MKSILSIFLIFNIILFESIQNSEISNLLISKYSSSSSSPYSSSDGIYTWNLKQTLSKDSGSFGTLVAIYKNIMVISAPGNNRVYVYRYDGTNWNLDDILSDSAVNFGYSIAVYEDYIVVGAYGDQKVFAYKYNGQIWSLSYTLSESVSNYGKSVAIYGYWLLVGAPDQGQVFVYCISCGFSKVQTLSEDTTNYGDSVSTNGDWFIIGAYGYQAIYIYAFDGTNWYLYTSFQKTSYINFGICISSYENVIVVGSEDNTVFIYRYDGANWNLEKTLPGPSYFGSSVSVYENVIIVGAAAYDSNQAFIYRYDGTNWNLEKTLTGDSFSYFGDSVSIYDNFTVIGSFDSKAFVYEETLILQINILNCSSLFSSFECYWEGIQSSFTLKYQINYGIDWIDIQNPIIEDENIYYQQFNSSIYDNITGNEYYSIQIRVCDLESSICGESSSSINLITKIDSVKDFQLLNPLNYSINIIWIPPNVQIDEGIAHLNHYNISYFIQSEPDSIYSILVDNSSTSYLLDDLECENDYEISICGCRTFECEEDDKGEIIESSISKQFETISNLTCSISYSIDINCNWNQSINCSIPFYYNFTYQSISQNDSGNYQSYSLNQQFTAQFPNQEYQINVSACNSNGKCGYISSISITTDNLPISPIIYDSIPKIEEIELNFTKLNNANNYSISLDNETNWQKFTSLDLSGNEVIGTISEISGNIEYNISIRGCSDLNCETSYLGESSSIISTKAKLGNISSLSCKSFMLGFYCNWDSLELSSGLKAYSFNYNSTSICLTNLTRNYSISTGLKSGEYYEISIYSSSNSNCSINEYSGINSTTSIIPLSMQCDIYQTSENSTNTTAITIGIIIPILIILMIIIGIIFIKKRKKNKVIQEIIKEKELHTDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCZ1</accession>
    <name>A0A9Q0LCZ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Calponin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCZ1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="211" mass="25054" checksum="C308179E1D971184" modified="2023-09-13" version="1">MDKKQFGNQMKKWISSIIDKDVDFSIKNRYQLIEDLCYLMSKLEPHLINQNQNKKLTPKEKWNYFINSCLKYGVSQEYLISFHNFLKEGFESRVLLLIYQIGSISKQRQHSIERKKNKKQNLNETKIALKNSNSFENANFKNFQNKKILSNISLTHVKKNLNSNEWTTNSLQKQIFTKKAKEQKTNKKNDSKILQNKKQLENELEIGKRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD44</accession>
    <name>A0A9Q0LD44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beach domain-containing protein lvsc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD44"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Neurobeachin beta-propeller" evidence="5">
        <location>
            <begin position="66"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="346" mass="40404" checksum="A7D738DE3202B04C" modified="2023-09-13" version="1">MNHEPDQIITINKERIIGKHKFYLIESKNKKPKITLIIDDEKYKQNQKEKIREIPFSKDLNNFEECFKNYENSKYLIFCGFEDNSFKIIDIEKYEIIQNIYKHNDIISCLDIDLKYIVTGSKDTTVIIWEIESKEKEGKIKVKEKPKYIFSEHEEEVRSVSISVEYDIVLSGSIKGKLNIHSLKKGKHIQTIITEEKEPITNIKITKKGDIITFSENSNILRLFTINGYLIRRFQCSENIYSISISEDSNFIFTGGEKGIFEIRKIFNLKPIQSFDLKETIYSISIIKRGFLIIIGLKNGFIKIGYFSNTTQNQNQNHKEKEKINSNSNSNSNSNSNSKSINIFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD62</accession>
    <name>A0A9Q0LD62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">La-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD62"/>
    <dbReference type="OMA" id="WIELEIF"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF62">
        <property type="entry name" value="LA-RELATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="9">
        <location>
            <begin position="137"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="233"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5069705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="390" mass="46842" checksum="F9EB3773B9BB22ED" modified="2023-09-13" version="1">MIDNLNQNQNQNQNQNKNQNQNLNQNQNQNQNLNQNQNQNQNQNQNQNKNQNKNQNQNQNLNQNRNRNRNRNRNRNRNRNRNRNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNKNKNQNQNENINQNQNQNQNQNQNQNINHLIKIQKQMEFYLGDSNLSKDKYLKSFLKKNNQGWIELEIFIKFNKIKELTENITDLVKSLKESKALVVDEENLQVRRLNPLPPKLDFTNRTIYAEYIPKNSTRESLTEIFKKYGEISYISIPRFPNSKKNKGFAFIEFFDPKNVENVVSNFSIDFPNSKIQIMKKSEWIELKKELNRILKKRQMEKQNENQNENQNENQNENQNENQIQELKKRKENPKKSKNIQSNSQNDLNQSFKEDLGVPIIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDD1</accession>
    <name>A0A9Q0LDD1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDD1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="16440" checksum="0C80B880C1F634C9" modified="2023-09-13" version="1">MIKLKLSARSTPGTICLMLFMIIPLVAFVLPSILVSVPDRDKDCPKDLWIWILVCNSVFTAIILLAGFTQSFFYDTFALIMRILNLILTLFLFAWAILGIIWARSNGVKSECGKLYSVTFGDSVALVVLMSTSLVMVIIVVIMVLTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDH7</accession>
    <name>A0A9Q0LDH7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol-4-phosphate 5-kinase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDH7"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF266">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_53, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="99"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="229"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="998" mass="117622" checksum="253A4A64235D32A5" modified="2023-09-13" version="1">MQEKSNIQKNQLRNSRENDGKNKIFFNTQTTTEKENEKETEHMEAPDILKMLNLENLAEKINKKPRELPKILQEKSNEKKAIPSIRKNYNFQKKVQFPNEKLSLAYFKQFLQQQLSEENILFWEAVKQYNTILDPVERIAKAKEIIEKFIDFSSLQEINIPDLTKKQILKKVEEEKFVPDLFNDASDMIFTLMKTDSFPRFLHSNQYTELLKDRERIKNNQKPIGPKTKRDELFEIIYLHEQKYLESLNKFYETAIKPIQNELGKIIEHQIFEKIFEDILEIYSFTQTMFIDLTTRKEKWNYESCIGDFFLEKISEMSQLYQRYFSHFKIITETYKEMMKNKQFQKFVKALEFNTSAEIEKMLKIPLKKMDELRRFIKKLQEITSLDHPDKKHLVKLSTTISSLTQNIQQKKVLLMTLDPKTSEIFSQLDISRMDIGKVIEYPYNPEMNQKIIQVFLFRKTLAWCFCSRVTGKFEMDYMSSLDFVWISDFDEIKQAERKTMSFQSSSMIITKLSGLSIKTPDRYIEIEIPNKQEFITDFYNHLSLEFSYKEEDIQKNIERIFTFPYRNLTRHTGAFQNAIPVGQSQIKYPNGTIFEGMFVNGKKEGNAVVEFPTGDTLKTVWKNGVPNGESEMVDVDQNHFIGFLVDGKKDGDGKFSDVSGAFYQGEFKNNMFHGKGNVSYSDGSQFNGTFQDHSRNGFGKFIQNDTFIYEGDWENDLRKGKGKQVYQNGDIYEGEWLDDLRHGKGKFQSGIAFYEGDWQYDCKNGKGLMMWNKTKWYDGEWKNNLRHGYGVFVNGNYKYTGHWRNNLPNGKGELCYYQKNIEKRLSIIQKDRKELPILTDSNDSVDSNELNNPMIQNEQEPEILEKIVGNFLKGKPHHHVKYYISKRYRFEGEMDMGKKHGEGTLFFENGGKVTLHWNHDKPNHEQSTKMEFVSKTGIFRLNYDLSGAISENVTITSENNNTIFEKKRDENVQKINEHFGEWLLPNNLSLIIQGNWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDR4</accession>
    <name>A0A9Q0LDR4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDR4"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043988">
        <property type="entry name" value="CCZ1/INTU_longin_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19032">
        <property type="entry name" value="Intu_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU second Longin" evidence="4">
        <location>
            <begin position="208"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="65099" checksum="00574027FDE82B80" modified="2023-09-13" version="1">MNYIISPQLFSFAVFNPSLQESQKSEISKIIHFFPSEFHIQKKLSLIGFAEGLITFTQTFEQKRNRLSVHLQKQRFNLFQCEPNFWMILVTTNPSIQSKNQANINSNIDKKMQNNSVLQKILTQAYEMFCFFHGSFKRILERFSLRTLQNKLDLFMPNYLTSIDYSQSNINNSINVVFDGIPYLSLNPKIFLRVQCFLNQIELNLPSIKYSLFYYKDQLLWSSLNEKQTILLTEFLSKKLFSVKMGSNEEDKQDQEFENFLTKVQVKSTKHSNLNIQNNFKENKETSFISQHKTQSQKDITSSKNQGKLHKMKNSQSFNEQKMKSLIYNFDSFQTDSKLPENQTVSKANKGNVSWNKLPRFVMGPENIQDPNTAFNTIRVFTGKEEKENSLVIYQVYKIIIVFIVDPQVSIDVSFYQKLEMMIANEIFTIGINIGDLSLQKHEEFPLNPIIFFWSPLTNMKQFFSVKNRSHFSKKNIRYILSLFKDFNNRNPSPKEIILQSQEYWIFAGRSETCMIFVIFEQKNLPFTQAFELFGKLQERFYYSRSIENQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDY1</accession>
    <name>A0A9Q0LDY1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase complex subunit sap18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDY1"/>
    <dbReference type="OMA" id="HHSNEDF"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="156" mass="18417" checksum="79B2333DE45BF7F8" modified="2023-09-13" version="1">MNNFYNSKKSYQNQNRNQNRNQNQNSKKLRRKNRSGINRKKITPFLLSTFIRVGKKNTIQDYMNELPHNELQIYTWIDATLKELTSIIKRLCSPARQKNAKLSFAFVFKDKYSGYIMFKNVGYTFSSKSSDNDFKTLENLGFRIGDFLDVAIFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEA4</accession>
    <name>A0A9Q0LEA4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-17-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEA4"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="355" mass="40799" checksum="FE7F9A3E57B72314" modified="2023-09-13" version="1">MLNEENNIIVIDDGKYQIRAGFPGNLTPNFTIESESTIPQKFSNLIPKGIFQDWDYIEQTWTEIFKNKMQIDPQTHKILVSESPLEPIQNRFVKAEILFEKFQFQKAFFAIQNVLALYGSGKTTGVSVNLGFDTISIVPIFDEKIFPNSIKRLEIGGWDIDQYLFQLLMENSQNKNLAQQKSLSAFIRKAKEKFAFLESNNFDSSNFLLGNITKKQALFQEHPEIRIDWNDENSKCAEILFNPQLYGINNFGIQKLLHISIDKKSPLLSRKKLFENILLFGGSSQIHGLKERLSQELPLLTSKSLTFNIDAQKSNENLVWIGGSFVASKVLRSTDWIDKSEYSEYGESICYKKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEK2</accession>
    <name>A0A9Q0LEK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btb/poz domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEK2"/>
    <dbReference type="OrthoDB" id="408604at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="211" mass="24959" checksum="6333A2DD05F1AD9D" modified="2023-09-13" version="1">MNKNINKNNQKEATKILHKNFQKILKIQKYEDISIWVGKGETKTEIKAHKIILTSRSEFFKMFLNQEESSEIYFPNTEKTTMEWVINYIYTGKITLNENVDLVPLLLIANHFQLDFLSSFLEMKIIQKLSKSNVCHIFHQNDSIQSTEINKKCLDLIDTHFSYLKKKKSFLELEEEDLDKIIQFKITKNQNFTFPFLPNDSAMDPTQNRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEQ8</accession>
    <name>A0A9Q0LEQ8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_10579</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ATNTCRI"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1276"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1650"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5071095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1683" mass="192897" checksum="5A01F510FE227156" modified="2023-09-13" version="1">MGNQLDSLPKWNYLYELEGYTLTDQVKGGRFFKTMKMMKDDSGPVYVKVFPKHDPSTNFRKYKKLLNQIKSNISSLNSSNFITHTDLVETNRAGYLIRNYLFSNLKDRLSTRPFLTSLEKRWILYQILMALRDSDGVGVYHGDLKTENILITSFMWVFLTDFAIFKPVMLPQNNPSDFSYYFDISGRRKCYIAPERFFLEPDETISKEKINENQNENQNENQNQNQNQNQNLNLNLNQNQNQIENQNQNENSIEKEKENPTKSQPTLTSASDIFSLGCVISEMFLDGEPLFHLSELLSYKKKEYDPIQRIQAIQDPQIQDLIQSMISLDPSQRKKASEYLTECEGTVFPNYFKFYFPLFRNLLFLIPDEKIEYIVKNIDLILQPLTSPQTELIDDSQTKKKSRSVRNFQSSHDSSKNQLSAEQEMKQKWISLSHFHSEKSLLNVQNFANQFKNRFQEKQNQKQTPNSKKDLREKKLLKTKTRHLKIISDLLEKEKNSDPKKMPKESIIVKMRNEFQRRVENKRRRSFQGKLSEGLVLVLNILLSSIRNCFKTSTKINGMRVICMIAEYLPDPLKIERIVPYMMSMLSDSSAVVRAEAVITATCVLEMVEEISLSDQPLFVEYILPFLHTLANDSELVVQITLAKCIGRLALTAKRFAELGELLSRKERELEKLKTEKQNGFSVDENQNNGNDMNENITQQNSDSENLIRKESEDEIYDAIEAENHDFEIVKKTGRGTISSDVTISISSHLESLETQFVAIFTKMFGDLQVDVRRALLGRVTEMCIFVGRSTAVMNILILLISCINTTEWTLREEVLDRFVEIAVFMERDQTEDVLLPCILEKLNDIEEYVVEKALDTLSMLCDLECLRPQTIVRICQKTFPLFIHPNACVRFGVVGLFHSATMQLRESDTNFWIRSWITPYLTHSLLKIKAMDVLSHIYSPLYREKYDYIIRTMLLTGNPLHYLLESTNPSFSPEEKRKVNFLHDYLLDAANNPSRREMLSSEIKRENEKQPLDIFQGYQEDSGQETPVFSIIRAERKKKPRRSTQAPNDLVRSDSSFSSFRSFEAEWQDMFGSPNLSRKAFRTLRGSIKNPVKSSLSFVSPNNPLIDFPLVTSNPQNSDLLISNLSRSPSLSVTPSNSSLDSFLIGSFADRSFLSESLGNTHQSSKKKLKQIETENIIIQNTRDLIALIFGAIPLASSPQIPVEVTNKIDTHFDPNAQKLIRSKIIKASRRRVFRNIQRIIHTNADPQIQPIPTRAKTEDSVQSWKPLGVCLATMEEHTAAITRIAVSSDNLFFATSSDDGTARIWATSSIGVSNTLHSSGAFESKTGKITSLTICDSNKLLACSTSFGEIHFFRMDLHSSEKSKSLTKEIFESSKKFKPPIHQKIYKSINQFNPHEGCIVDLLSLSNSGNIPYSLMYATQKGSSHVFDLRTQKNALDISIPLNLGLINSLAVDPQSNWCAIATSQAYIQCFDLRYLIPFSTWQHPYLDSISRLYYFNNPHSNFSLMIPTINNEVGIWDIRNQKCTELFQVSESSDNEIPNLMKYSLTDETKDSKKDQNERKVNPNSILSVWTPQNSSFLLTGGTDSCLRYWDRSQISNSFIISGDRPSILYSSKKYENLKVNSEYVGDNETLSGMILKSPRTSLQKIYSRHKASITDISMIALDSPMIISGSRDGVVNVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF66</accession>
    <name>A0A9Q0LF66_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF66"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="480" mass="56419" checksum="971BA499A10D6E4E" modified="2023-09-13" version="1">MKKNYNNKNKQTSLHIVCKFPKKKSFQKIKILIDNGANINAKNKSKETPLHYACQFQNKPNSFEIIKYLIENGANINAKTKYHKETPLHYACQFQTQKINLIEIVKLMIEKGIEINTTSTFHGSFLHLICEYQKENAYEVLQILLENGADLNAKDILNNTALHLACQFQKTNNLFEIVKLLVANGADVNAQNESGKTPLHYVFQFQNKLKSSETIKYLIENGADVNIIDDNGKTLLQLICENEIIQTTKNPKISEVIKLLIQKIRNIDLNIEIENDLHQKIPLFYSIYKYDKDLITLLMINNADILILTDKQITKEMIDLFPKIYSINQDLNNLLNSNDNLSDFEIETNDSFKFKVHKQILLLRFDYNQLNLQKFINNCKRKSKEIVEIVINFIYTGFPNFDNLIQKFQVLKELKFKEKENKEDLKKYNEYQKYGYSDDDLLGINHSFYYEKIKENKKIFEELKEKFEKIEKEFENENEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG97</accession>
    <name>A0A9Q0LG97_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG97"/>
    <dbReference type="OMA" id="GININPY"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="266"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="381" mass="43568" checksum="45B780C9CA8BDF5B" modified="2023-09-13" version="1">MNEIIFFGYNKYPKLFKNKPNKITKPIQFKFENENENENEKQIKQISSSFFSTIFLFENGKAIEYLSENDSNENPVKIQIEENIQKVTVGNENEAILTIEGNVFAKGININPYNPNEFINISSLIEDTNDRIIEDIVSGSRAIYLLTSNQNVYGIGSNQFGQLGFDSKTLPKTENPILMMKNVSKIFSGNSSKYVFLLNLNQELFVCGNNEYGQLGLGESRKEETKIQKLTKIQNIPKGKIIDIQCGSIYSIMLIEIEDQNQNPKRKLYSCGDYQYNGLGKNDEDTYEFTEIKSSLFENDNILDFSVGNAHTLILTSNSKLIGFGYNEYGVLGTGDTKDQSIPIQIELPKLRFNEEIFNYHISCGFDKSFLYYSPFFFFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGG0</accession>
    <name>A0A9Q0LGG0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Wd repeat-containing protein pop1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGG0"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="186"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="412"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="518" mass="60346" checksum="39153C0CC404FC9E" modified="2023-09-13" version="1">MNFFRRKKKPKKPKLQQKPQLQQQENKEENKNENENENEKKELPLDEKFTHIFEGHSSEIRCLHIYKDFLFTGSYDSNIKKWNIENQECLGTVDAKSYVFSLSVYKGVLYSTGSYLIAWDPETFTKLKEYSSSFGGYIFCQAFYENMIYTGGAEFLLRSFEIKDQRLANGEIYIWDLNNLHHIGTLKDHTNGVWALVYANGFLYSGSSDHSIGKWDLEDQKRVGNWKENKDSIVFMAQKDKLLFSGDESGYSVALDMANDQVIKKFRAPVCVWAVGVTENYLFLGSRDSKIRSWDISALFISISLKEDLQILFDSQEFCDNQIETFDGSLKIHSLIVFFRLKKKPTEIISFFENQSIQVAKDFFKWVYTGYAKDSEQIKEILKNLEINPENRLESDSIIRMMNELYLDEETKDFTILVRGEEIKAHKIILFARSEVFRGMFLSVNDSSNSVSDYSDKSPQAIKTVVQFLYTETLSDDTPLEVLEEIKDADDFYQFNLKSPFQKELDRLSLPKIFLDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGX9</accession>
    <name>A0A9Q0LGX9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exportin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGX9"/>
    <dbReference type="OMA" id="IAKRSWG"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="2">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1189" mass="139606" checksum="D3BC3B020FCB4DA3" modified="2023-09-13" version="1">MNSQNQKEIEKLVEAIQIIHNPQTIQQTREKAEEFCFQFKNNIENLPLINELSIDTEAPIQVRHFAFHCMEHLIRNFWNQSEELQSDLKNRILNIFINLDNFEEKQIIKQKVIVLVIEIVKREWPQKWPDLIKELVDLGSRDFVKQELCLMFIRSLSDEVFVYVEIKDLSSTRRKKLKKSLVDEVDTLLKFTMNSLDLHYQNYLECVSGDINNKNDGNDSLANNLQISSKIIVESLITLASLFEWIPHNLIFENNLLLALQTLLVEKEFRRLAASVLLVFISKKPQNNKVDQNQIISLITHFINFATDIFQQNDIEDDYIFHKKITQFLSLFGQNYSFIFLEKSQNQFFENFIDLLLQISSHPSLMINSFIISFWLHLIKKWNPIISKIFDKNIPQILNEIFSKLMIMSSNNENESTIFSIMDFQIESQFKEFCHTFRFYILELCRSFGRILPISSTNFIFSEVEKFPSFLNEKEISDENLLKLQSISYVSRGILTGIKKRKEIDSKTYEIIGSILRILLELEIQNENVLVHVFNMMDYSLIYLQKNSQDSSLLLKRYLSYLTIESIQGTNKFPLRRAIYSSIYHISQINGKDLINSLPSLIENVSEIIQKGFMTEIEKSNLLQFLILISNNSSNFEEQESFITSIIESELQEFEDENLTFILNDTKSFLQFIGADCDKIPNEEERKQYFQNRNKIFSILRLFLSIFRSVHLSSDPKISQFVFNNTTFEKRKPTTRIAMRILPNISNLIKQFHLLSDPHVKQMHLLPQYHDIVDPINENENENEDEIEIENEIENFLFDNKSIPEKLEINQKFQFITKALQKWISLTRNMIYNFVHVCFEDNDEIFLLENLQDLFSNFLVNIENLNEENLNQVIKNILKPLAINCPECLIEKCVFPIIPEALNIISKKITLDWLTVSQIRDNQLTGEAKDEIGFESKVIILTRSFSHLLKSLIRTNLNLKNNQNQNSQDEKIDSNLDSVSQENLNILKLILVDSRIIDSFLSSLVIFYDIPEPNSLRRAISISSLVVKSISIYQINSLYNFVFETLISVIFNSFQLRFDGNLFRSLNSLLFEIIFNFTEQNSQFEIFQQIKKLSNLTTENINELENLLKQSSSEKIAKKVLFEFLETFVGLNLTANQQNPRILDLPEHSFLHEKTKELIAKRKKEEKRKEQEELFLHSLDYAKTLFQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH75</accession>
    <name>A0A9Q0LH75_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH75"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040230908" evidence="1">
        <location>
            <begin position="21"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="511" mass="58243" checksum="8B528B60BE1EF583" modified="2023-09-13" version="1">MKIILFFCFSFTILISFIQNQPILNNSFDFPIGMRNPVFSLIDETNGFVYFLDCDLDDYSLNSSFYKSDLNTLDFIDSIYFENIDISIGVIDTINQMIYFGAVTLDDFDEEFSQIIQFDLSSFSISNLLNFSSLDSNFLYSEIDLINSKAYFIDSSDDTSIFKIDLSTFSFESNSSITGDYSIISTLIDIENENLYLFTEYDDDSNIEIHKFDLQNFSEIDILTLDQIPNNPESISGIIDNSTNLMYFGAFYYSSQSLFIVKINLTDFKYVDHITTILEEDTQVMKGGIDELNHLAYFLTSPNCMIFKINLTSFGFIDLYEFSNLECVLSFDSSTTNTFIGFNDSTIINFDLISFNPIKSGFILDFQNASVILIDELNQIGYVGFDYVFGLVSQINLTSFEIIDNLINDNFSDKIKCGEIDLSNGFAYFFINCEISNSEIIPKIMKIDLANSTNSEMKIIDSNGEIQTSCFDKENQIIYIGYSNFTEGNGKILEINSPNLEIINSFTISDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHD9</accession>
    <name>A0A9Q0LHD9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHD9"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="686"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="968" mass="113532" checksum="01862A1CBD7E3419" modified="2023-09-13" version="1">MKPQFPKKHFERNFKPFPKPKFPKFQNPKNSVSKNFEPPKKTVETQPIRKQNPRRNNRKQKEKEKRKDITDYQFNNLLMNKEIEDEVYVYLCFDYFVYDEMLISIKSQENNLKANTTESNDSLPLPKIPPRPGSQIFSSFFLRKSQKKKRSSTSIQILNINSQSKHIQTAFPDEVVDARKKLNILRKGSSQLNEKQQLIAIKILEISSTFPEPVIPPKATKPLAILSEFISKKQSNTQNPRIQSKKEEIILKEQDQLSKKSSNQEQEDHEIKKPKVISSPKKIPAKNISSSVRLPKSDSIHQGSPEQKVEREIENQEEEKEIKKQNESKITNHFIKRKNFDRHAISIQNKHNFQRKTEDLLSPDYMRSLENIVSETYALKIKQNQSLDPNAMNRKFNYKPKKKKNKSVLKDQADIIMQEISIKKDLDTKKTPRLNTNEKFIPTFEEYKKLNKIIERPPLQELTEEEKDMIWKFRNTLRVNSRALPKFILSLNLDVEFERQEMIRLVNDWKIDIVAILELLSKNFIDEYIREFATNQMRKYDDDELLLYLLQIVQGMRYEKSEKSALVQFLIERALNNKIFGTFFYWYIFSERNDHDYSIFGKVLLEFARQCLETPKNKKHLLRLRRHEELVNSLKHISEAIRTNKDPRPKKITHLRENFPKDHLDLVTFEKMPLPLDPSVFITGIVPESIYIFKSALCPLKITFKTINEKDYSIIFKAGDDLRQDNLVMQLILLMDRLLKQENLDLKLTPYKVLPTSADVGMIQYIDSKSLSSILSDHHNKIADYLIKNNPDPETEYGFTPLVMDNYIKSCAGYGVITYLLGVGDRHLDNLLLTPDGKLFHIDFGYIFGSDPKPFPPPMKLCKEMIDAMMGRKSTHYNYFKLLSGEAFNVLRKSAYLILDLLSLMIDANITDFQKNPDAIPIIYEKFRLDLNDNDAAQYICSVIDESVNALFPQVVETLHKWAQYWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHE1</accession>
    <name>A0A9Q0LHE1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquitin conjugation factor e4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_10130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHE1"/>
    <dbReference type="OMA" id="SNAFMTN"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5071498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1114" mass="133156" checksum="2A0733F843115C4B" modified="2023-09-13" version="1">MKIKIKNENQNQNQNQNQNQNKNQNQNINQNQNQNIFRINSQNWKQIRLLEKIFRVGILAKNPKYPQFFLDSLHKEIKNQQINLKEKFEMLPDLIIAEILAQGKIYNPFQYLLKCFIDAQNFQETNQNNLTSEKIKDFIVGYFYILINSPQIFPNILLPENLINLIAKSFFKENTLKHKIYANQEFFQKLFNRFKEDENIENGIFFFRKLNTLFAEKIRNPLNFFDIINQLKVFEVMYKVDLIAKIIFEFQDDWEKNDGNELQNQNIPFLSAISQKLKPLLLEKKSNLGAFFSFSAMDNMPFAQLYFPNISRTFQFDFSKKKDFLEKEFHFVHNLVYTIIMILLKNPETKPRVSKWIQDVIKSNRERIQINFEIGLSHKTSSNGFLHNILLFLLKITKPLLNYGEIFFNSLQLPLKIRMNFNSLSFDISKEIKLSSFQETDERQNLANFRGQQNLIKEFIENYEEKLKELYPENDENNENNENNENNENIQNNENNENNENNENIQNNEIEKIEKIENYFFDTIRIIQIGLIPNLKQYHLYLQEWSKIDKKFRANPDENNRRILENLIHKRIIFDIHLFDIVFVKDMIDYMNLMSKWILSTLFLNSNQKMIDFNEIQLPLKLEIPEEFTMIPSFFLETICDTLFMFTQFNPKIMKQIDLKPLMDMFIILFASPKIISNAFIRSNILKVIFIFAEVSVKKNYLALTNQYDPKRKNEPIFLRDIFSHHLLTQKYLIGSLLLFYLEIESTATHSQNVEKFTSRDFMVKILVTLLSPKILKSNDQFTNENTNENINENTNENTNENTNENSKKIEIQEKKENLYLSLFNKLITSSKLSFQFVNTFMNELTVIWNYIFDALEKMMETEKLIRNPTEWRNLIQEEREERARMFQFQKSQIPGLMDEFYTFLDLLKTFVKKTKIVEFFLSDETIHSLVIFLTQDFGKILQPQFLSMNISQQHDYNLDPMKIVHQFAKINILFKKFPEFIQISSEYPQILEKEIFIKASKFLQQNEKIDEKIPKELESIHKLIQENIEKMKQVEIDDEDAPDEFLCELEYSLMEDPYLVPTGQIVDRKNIVRWLAIKPINPFNREPLTIEMCKPLPELKKKIEEWLQNAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHN6</accession>
    <name>A0A9Q0LHN6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHN6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="257"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="623" mass="72963" checksum="EDCDDF82F91DF4A5" modified="2023-09-13" version="1">MNEILFFGSNKYSKLLKNEPERITNPIQFKFENENENENEKQIKQISSSFFSTIFLFKNGKAIEYLNETYLNQNPQKIQIEENIQKVSVGFQNEAILTIEGNVFAKGKDTDSNQFINISSLIEDTNDRIIEDIVSGSESIYLLTSNQNAYSFFSGVETFNFRSLTYKKTKKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGCGYNFYGKLGLGESKKEKSKIQKLTKIQNIPKGKIIDIKCGGWHSIMLIEFKTKRKLYSCGNYQYNGLGKKYGEDTYEFTEIKSSLFENDDNILDFSVGENHTLILTSKPKLIGFGHNYFGELGTGDTKNQLIPIQIELPKLRFNEEVSNYHLSCGENNSFLYYSSPPFSNLEEDLIKLFRRKEFCNISFKTENGEIIKAHKLILKYRLNQNENEIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIKIGIDYFQLSQTNPNLFDLLINKFNNQNQIKKEQKKKTKEFINQLNQTNPNLFDLLITKFQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHY2</accession>
    <name>A0A9Q0LHY2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Wd-40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHY2"/>
    <dbReference type="OMA" id="FHTCEVY"/>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF33">
        <property type="entry name" value="HELP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="842"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="925"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1179" mass="134270" checksum="1E1252E4B1B4ADDB" modified="2023-09-13" version="1">MSSMQKKIAKRKEQAKKEKLKREKQLQKEKQSKRQAKKKAGKTTKKIYFNWFIINVHSAKNLPVKTSFCSVFLGSTMTEKTSVKNDSSDPIWDETFYFGLATQPRLCLLEVWHAGDTEIKIGGHEIPLLDFQPENFKRETFSLKTGKSEITVEYMIHIFETMQKKSDVIKQFEFPKTNELPVQSNSPKEETKSNSPKQEEIKSNSPKQEEIKSNSPKQEEIKSHSPKHEEIKSHSHSHSHSHSHSHSHSHSHSHSHSSKHEEIKSNSPKQEEIKSHSPKHEEIKSHSPNQEVTDYSLKTPTKHQKSVHPHSEMKSHKTSKTRPLPKTPEPKSIHTIQDHNWKTTAKSDETQRKPSITTSPISTSPKTKDKPFYEAYLDKIRAQNGDSQKIQKPIENENQYENENQYENENQYQNQYQNENENQYQNQYQNQYQNQYQNQYQNQNQNQNQNQNQTNSEYSNLSNSPINLSKLKDTQSKIDEIKRRYSLEKKDKPNNLRSDLGVPRHSSFDSETTSVNEPNRKSSLVERKDVPYQQTPVKSEESSPKLSTQEYLRNLMNKYKPQEEVQLSTPTKLDKRQRSQSDSQIAFEIQNSQTQKVQHKKHHKTSLNHNQHIPQNAMGLQIEFVYGYHGVESRNNIHYTVNKDIVYYTAQVGVVFNLRSRTQKIFLGHTALISSNAIHPNKKYVASGQEGNQPLICVWDTTNVELLTSFNSKESGDVVALSFSSDGKWLHAVFGNDSHTVEVWDWENKKLLASQSGHENKVLCVECNPNDPSKFVTCGISHVRFWQLSDSGNLSFHEGNFVNKQKTMLLSLLVSKFGKTLTGTKTGEVYVWSSKYAIEKTFRAHVGPCLTLHSSSSTYFVSGGKDGKVCLWDEKNLTQVSRVDSIVAGPIRAVDFDSNGRVVAGTNKNQIWEAELSTGFATPIIQPHGDEVWGVATHPTKPEFVTVSDDRTVLSWSSITKQMITKMSINGQPRSVAYSPDGSLIAIGLRDGEFLVFTSDLKQVANRKDMTTSTTIIKFSSNMSYLIIGFEDGTVANYRSETKFRKSFDVHINGSVTAIDWSNTSTEFRVSNGKQTYYFSADRGKPLDNINGIQWETNTCEISQKLPDSSDFDILGACLVSTKNSSSLIITYPYPSLDLSQVTKYSGHGASVPNVRCLGKSHIISVGSKDMSVFQWRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI28</accession>
    <name>A0A9Q0LI28_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI28"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040449962" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="474"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="919" mass="104761" checksum="3EC9E234B9538542" modified="2023-09-13" version="1">MKSNQFFFFSFFFFLIINIFLIQSNQNNQKSISSSTVSTIIQELETTRLLTETTRYYSSPNEAWVWNLLDQFSGPEASYFGYSVSIYKDVLVIGSPQVKQVFIYRYNGTNFDQEQILAESASNFANCVSIYEDVIVIGSFGPNQAFIYRYNGTYWNQEQILTESASQFGRSVSIYEDVIVVGASNANQAYIYRYNGTIWIQEQILSGPSYSIFGYSVSIYEDVILVGTNLANKAYIYRYNGTDWNQEQILSESALQFGQSVSIYEDVIVIGTYYANKAFIYRYNGTDWNQEQILSEPSASYFGFSVSIYEDVIVVGTNYANQVFIYRYNRSNWNKEQILSESVSYFGWSVSIYENFTVIGAPNANQAFVYEANLIPQVNILNCSSLFSSFDCYWNKIEFFRTLIYQINYGYDWIDIDSPILEDENVYYQIFNSSFYDNITGNEYYSIQIRTCDNATMKCGESSSFINLTTKIDSVKDFHLSNPSNYSINVTWNYPNVHINEGIAHLDHYNLSYLNQSEPDLISFISVDNSSLYYLWNNFECENDYNISICGCRTQECEVDDKGEIVESSISLIFGEITNISCSISNLVDINCTWNQPINCSIPFYYNFTYQSIYQNDSGNYQPTSSNQQFTVQFPNQEYQINISSCNSNEKCGYISSISIKTDNLTSPIIYETISKIEEIEFNFTKLTNAKNYSISLDNETNWQKFTSLDLSGNEVIGTISGIPGNIEYNISIRGCLYLNCETPYLGLPSSIISTKAKLGNITSLNCISLINGFVCNWDSLILSNGLKAYSFTYNSTSICLLNFKNYYSITSGLKGEEYYEVSVYSSSDLNCSNNQYSGINSTTSITTLSPCESCEPCQKTDNSLISNKTTTITIGVIIVIVAILLLIIGIILFKKKKRKNQIIKQIIKEKELHTDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJN0</accession>
    <name>A0A9Q0LJN0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAj domain (Prokaryotic heat shock protein)-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJN0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="499" mass="59830" checksum="6581873913EA44D3" modified="2023-09-13" version="1">MDSNTQDSQFPFLNFSQNSEWDQTNFSQQSLQLQFSQDFDLRSQPSIPTEYLLESSQNTVIDQLNICCLCHLQHSQLLNCFECQRNFCYSCAQITMDEVNQMDDDTLNFWKCPTCLSWKAQVENPLFSNYWKERIFQLKQNTSFIENILSEMEQMEMNKSLAKIVYENESQKNKSNPKLESKYNQKRFRLFQDSNTQILQFLSSKNNTQNNLAKTSKKNSNSNIQNKNGTNHEQMKLMPEQEFYEYVHKEDIDKRDSIYARKVFQTLVNQKNTEKIKMRKKKRVNLWKRMISRKELRKLSLNPSRILCSVYFNGAILNEFLNSSQVVSSQKNLDNSQNNQENEKENRNEKEKENQKENQKSKIKIKNQNQNQNQNQNQNQNQIQNQIQNQIQIQNQIQIQNQNQKKQPQLKKSNQIKKNNQKKKNDDNFPYEFDMQIDYYQYYLALQKENKDLKIAFEKLTKSKKNLEEKIGNLEKQKNNILNQNQNHQHKKRKTRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJW9</accession>
    <name>A0A9Q0LJW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High mobility group protein dsp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJW9"/>
    <dbReference type="OMA" id="QRIYEMS"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="170" mass="20047" checksum="500A8BF824D7C585" modified="2023-09-13" version="1">MEDKKRKIENPTKLEDNTENLEEEKRQKIEIPSPPKKPLNAYFLFAQDCRPRIKEQNPEIKGSEITKMIGQEWKNLPQEQKDVYKNKQQQLQEIYNKEIAEYLIKYPPTAQVSISDEEDESIETAEDESDQDYQDKVPEIDSDAEKDEYYEYLETDDTDSHDSDSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK36</accession>
    <name>A0A9Q0LK36_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ap-3 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK36"/>
    <dbReference type="OMA" id="INVHFTI"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="168"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="406" mass="46548" checksum="F932C9ECBC7AB025" modified="2023-09-13" version="1">MIKTLFLINNNGDVIIEKHWRGLTPRSVAQYFWNEISNYENKKDAKPIIQTQKETLIFIERVDMYYLAVIPIEGSPLMVVEFLDRLSQIFAKFFGKMPTEDVIKENFVIIYELLDEMMDNGFPLTTEPSVLEEMINISKQRSVKSSDLIPTGSLSNTPWRKPGIKHSPNEILIDFIERIDTIIEVNGTPVTTEIDAKALVDCRLSGMPELTMSFNQPRLVEDISFHPCVRYNHWEQYQKVNFVPPDGEFQLLTYSIKSPNIQVPIYSDPIFKWEKNKGVLDLKIGIKNNQEKPVENVSIIIPFPKNIEKPKLVCSDGSVLFDESSKKIKWKIGKLKERASHLSGTIPLTPDTAPPEERPTALAEFRVVSLSASGLKVDRIDLHNENYKVFKGVRFITEAGNFQIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL93</accession>
    <name>A0A9Q0LL93_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gtp-binding protein rhoa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL93"/>
    <dbReference type="OMA" id="WIKEIDH"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001179">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="21739" checksum="CF3414AFAA53D4EF" modified="2023-09-13" version="1">MTKRFKLVCVGDGATGKTCLLSVFSKGEFPELYVPTVFESQEKDINVDGQEYLLHIFDTAGQEDMDRIRPLSYPDTNIVLVCFSIDNHESFDNVKLKWIKEIDHYCPNINIVLAGLKTDLRTDQETLDSLKAINKEPIKSQEGQSLSIQIKAIKYVECSSKTNSNVTQVFEEVVKAALTKSIRGTKSKKCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLG8</accession>
    <name>A0A9Q0LLG8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_07238</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIB43A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLG8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008805">
        <property type="entry name" value="RIB43A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05914">
        <property type="entry name" value="RIB43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="40"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5075666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="235" mass="28604" checksum="39FDEDBDA5116F6C" modified="2023-09-13" version="1">MSNCQNEIIEKKIKDFSQNISDPFFFLIQKMINSRFLNDEEEKERRKIEFRRKADQERKKRFFNEKIRLFGIDKKGIEVQKKEKEKERKEEEKEKKKMEKEILKHQEVLKKKEEEMSNVKKIIALQIQNENKQKRLNVKNDKENQVEHIGLVSKGVLIGESQSKPTRLDFRGLNYEEKNQISSQNSQLIEKQKEKKQKLIQKRKIIPLLNQEKFLIEKKRKYSRFNNKNKRKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLK3</accession>
    <name>A0A9Q0LLK3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-10-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLK3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000002">
        <property type="entry name" value="Muscle actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="392" mass="45346" checksum="71297D996A4A906D" modified="2023-09-13" version="1">MEINFPLKLNDENFSNQEPFQTVIIDNGSYLTKVGFAGEDEPKIAFETIVGRIRSPHSILVGMNIRDSYIGEEAKKKRGILMMRYPVQNGIITDWDNIEKIWFHSFYNELRVAPEEHPVLLTEPPLNPKLNREKTIQIMFETFDVPALYLANQSVLSLYQSGRKSGIVVHIGDGFSSVVPVYEMFALNHAIIKQNLAGKDLTEYLVNMLNEKGNQFFTSREIEMVNDIKEKLGYVAYDFDEEMQFSKQSISSVQKDYELPEQDIIQIGNERFKCCEALFNPHLIEREEKGIHQMIYDSIMKCSDEMKTDLYQNIILSGGSSMIPGIEYRIQKEIYKLNHSDSDIKIISSPERKYSSWIGGSILVSILNFKDMWISKEEYEEFGPIFINRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLT1</accession>
    <name>A0A9Q0LLT1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLT1"/>
    <dbReference type="OMA" id="ERTNSFC"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="297"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="362" mass="42678" checksum="0B1D694B40D1AB18" modified="2023-09-13" version="1">MDQILRITNNIKISAEIEQKPKKTNKKTKKAKNTPKTNDFKFLNTLQKGQNSEIYLVENEKDKKQYVLKLIKKNSISNDKDLQRLFAEKTILCEIKNPFIVQLHHSFLTETDFCFLIDYINGGDLYQILNYVHSFTENEIKFFAAELILALKAIHKANYIYRDLKPENILIDRTGHIHLTDFGVSKKLEKNERTNSFCGSLEYLAPEVLKNQKYGFEIDFWSLGMVLYEMFYGIPPFYSQNLREMQKNILNQEVNFEGVCSSEFKDLITKLLSKDPKKRLGSSKKGIKEIMKHPFFKEINWTNFSNKKSQPQFIPSFFFNQENLIQNENLELKKNSFPSLEKTNPTCLDKILFKDFEYDFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLT8</accession>
    <name>A0A9Q0LLT8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_06723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLT8"/>
    <dbReference type="OMA" id="CESINCP"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="189" mass="21269" checksum="BD071FB072FD9791" modified="2023-09-13" version="1">MTTLRIVVVGSGGVGKSALTLQFVHSKFIEVYEPTIEDSYRKQVSIDNKDHVLEILDTAGQEEYSIIRDSHLRSGDGFLLVFAVDKSQTLEQIPKLKSQIARAKEFSNIPMLIVGNKIDLVKDRKVKKSTAKQLADSLDIPYLETSAKTKINVDEAFLQISRLILKFSDQNPSLSNLHKRKKKRACLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN19</accession>
    <name>A0A9Q0LN19_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_07201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN19"/>
    <dbReference type="OMA" id="MVYQVVA"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="21"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="67692" checksum="8FE98D1FD4B5FAFE" modified="2023-09-13" version="1">MSEEEEFGHWGLLLFFALCVLAMLSAYFLRSRKILFLHETGASIIIGGLAGVCIRYFGGKLELKEFSSFKRDVFMLLLLPQIIFESGYNMKRRNFFRNMVSVLLFALIGTLISTFVIGGGLILFSHYTSVFTLTSIECLLFGSMISATDPVSVLAIFKELGVDLDLYANVFGESVLNDAIAIVLVDTFLAFEDSAVTTAFVFKALGTFIGIFLGSFAIGMAIGLLSSLLFKHVKLRHHPMIESSLIFLFAWCTYFLCEDLDLSGIAGILACGIVEAHYAYNNLSPHSQKITRQAIHVIAFISETFVFIYLGLAIFCFEHYLKFSLIATTIFLCLISRFFNIIPLSFLNNLFKKKRKLTAKQQFLLWFSGLRGAVAFALSVDLGTENGDVILTTTLMIVLFTVFIFGGLTQPLVKKMNIYASKEQKTTKKNKGFLRFDRKYLKPFFTRAKYNPNLYTEKPQTVPRNPLEEVYNLDPENQPQENNERTGLLSRDNPENKNEIENKYKSENVDDNKKDDDNNNNQDNQDNQDNTRYPDLPDFQNQSLSSDLSSENENQNQNQNQNQNGNQNGNQNQNQNQNQNGNYPILINQNHDKNDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN85</accession>
    <name>A0A9Q0LN85_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN85"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="319"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="490"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="611" mass="70918" checksum="C35E78354563EEE7" modified="2023-09-13" version="1">MKFIFFGQNQFPILIKNEPDKITKPIQFKFEFENENENENENEKQIKQISSGRFSTIFLFENGKAIEYLTEKDSKQNPEKIQIEKNIQKVTVGGENEAILTKEGNVFAKGIDINPQNTKEFINISSLIEDKNDRIIKDIVSGASSIYLLTSNQNAYGIGSNGYGQLGFDSETLKKTEKPILIIKNVSKIFSGNSSKNIFLLNSNQELFGCGWNQFGQLGLGESKREKREIQKLTQIQNIPKSKIIDIQCGLFHSIMLIENENENPNPKRKLYSCGYSPYNGLGTNTYEFTEIKSSLFENDDILDFSVGFGHTLILTSNSKLIGFGDNSHGQLGTGNTSRTDLIPIQIELPKLRFNENISNYHISCGNYRSFLYYSPFSPFSNLEEDLIKLFKRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTKDKSNKVTDYSELSNKSFQIFEYWIYSNHIKEGIQITQEIIEEIERGIDYFQLNQTNPNLFDLLIKNLKIKIKIKIKIKIKIKIKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNE7</accession>
    <name>A0A9Q0LNE7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Es-2 protein - related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNE7"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="488" mass="55571" checksum="8FC6CD5490FC1755" modified="2023-09-13" version="1">MKSNQIVLSNQENKITTTSKENKIEPIKKKQIILEEEAYLLGMNKIIQRDFCPDLESIREQTKDYQDFIESTQTEPNLFDLCGIESDDIIDSNGKTINTNLNLNKYLAKYTSQDNQSFAEIFEKMNQDALKRRKILSSKKDSNGELLLKDSLDETHLLTDYPEAKQTIQEISNAKTKKICYKNTRLENEFIENQLRTPKTPISPLTPTEYQQQYKGKTEEQEGDKKKNLDYIATPSPYIGSGEELDTPFITWGTISSTPQRIESPQINHPQIFQHSNFHLAKPTQREKVAESLTSKITNNSNKKKLTQNHMPLFKSPQILSSLRKTPSTIDTKVPSSPIIHNLATMSPAGLKLMMKLGKNSTPIQNSIKNLTPNRNLNFNPNSIKDLTPKRNLNSNQNSNQNSIKNPNQNSIKNPNQISIAQLKLQKNSTPLLVKVKKRKSPLSSNQSTQNSIPKNFSNQNFQKEKIPSYSLNVPKRKESITDGLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNZ4</accession>
    <name>A0A9Q0LNZ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rcc1 and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNZ4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="164"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="282"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="411"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="504"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="611" mass="71672" checksum="0760A1C8D9509F18" modified="2023-09-13" version="1">MNDCLFFGYNYQPILFKNKSNKITKPIQFKFENENENENENENENENENENENEKQIKQISTGRFSTIFLFKNGKAIEYLKENDPKQNPEKIQIEENIQKVTVGSQNEAILTIEGNVFAKGKDINPNNSKEFINISSLIEDKNDRIIQDIVSGSGSIYLLTSNQNVYGIGSNEYGQLGFDSKTLPKTEKPILMMKNVSKIFLGNASKHVFLLNSNQELFTCGYNKYGQVGLGESRREEIEIQKLTQIQNIPKGKIIDIKCGLFHSIMLIENENQNQNQNQKRKLYSCGYYQYNGLGKEDEDTYEFTEIKSSLFENDNIIDFYVGSNHTLILTSKSKFIGFGDNYWGQLGTGNTEDQSFPIQIEFPKLRFNEDIFNYHISCGFQKSFIYYSPPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNNSNINPKLYFEIKEIINSNEKIEEKMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSEISNKSFQIFEYWIYSNQIKEGIKITKEIIDEIQIGIDYFQLNQTYPNLFDLLIKKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP38</accession>
    <name>A0A9Q0LP38_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP38"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="260" mass="31458" checksum="E0BBD4F7636EFEDF" modified="2023-09-13" version="1">MDMIDLEIKSWIKEREMQKRKNERKSKFRNINAHLKSLDRQWKRENKIKMDDDPMKNLKIINSASLLMDGLISLYSDLWEKAKNIIQSQKEIGWINNIYFDTNFYEELSYKPFFDNEMSETFLKIKSISNQQVDQKSKLEVFLQNKEKNVQKFSFNYDKLMKIQPKLEKQINIVSNLQITGEKREKYENHLNFLVYDFQASLFDLFKSFFLLKHDANQYLSLEDEINLNEFNEETERIALQLTILYYLNLKNKKLIETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP73</accession>
    <name>A0A9Q0LP73_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antibiotic resistance protein mcbg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP73"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="162" mass="19329" checksum="B109C8C701F09EAC" modified="2023-09-13" version="1">MKKKIKKIKNPLFIFKRKISTKFYSKSSRIQNFEFIDCLFGPSTYFNTNFENCKFDGSRFEQVIFIAPSMMRPKLENCSFENVEFVNVDFPNNVPFKNQNFKGRCEINNICIPEEQFKSNFKGAKVTNLIDISKDKTKIKEIKEWNEVQSDIDKWKQYKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ66</accession>
    <name>A0A9Q0LQ66_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ66"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="492"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69875" checksum="0D11738F0A9F3B7A" modified="2023-09-13" version="1">MNDCLFFGRNYKPNLIKNEPKEIITKPIQFKFENENENENENEKQIKQISTGYFSTIFLFENGKAIEYLNENENENENPEKIQIEENIQKVTVGFDNEAILTIEGNVFAKGKDINPKNPKEFINISSLIEDTNDRIIEDIVSGAYSIYLLTSNQNVYGIGLNEYGQLGFDSKTLKKTEKPILMMKNVSKIFSGNSSKHVFLLNSNQELFGYGDNSSKQLGLGESRKEEFKIQELTKIQNIPKGKIIDIQCGYSHSIMLIENENENQDPKRKLYSCGRYFFNGLGKDKDTYEFTEIKSSLFENDDILDFSVGCFHNLILTSNSKLIGFGYNSSSQLGFEDTETQLIPIQIELPKLKFNENISNYHLSCGDYRTFLYYSPFLSSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIDEIQKGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQQ1</accession>
    <name>A0A9Q0LQQ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5'-nucleotidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQQ1"/>
    <dbReference type="OMA" id="ICSNPYG"/>
    <dbReference type="OrthoDB" id="10252832at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF38">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="386" mass="45754" checksum="3E13DFD7B25BADDE" modified="2023-09-13" version="1">MDYSRDSFFNSFQKIDFVGFDLDHTLIHYKIQELGKLVFDCLKRYVVEIRSFNKDLLQVEYDPEICVKGNLCDISKGNLIKIDNDNKVRRAFHGVNKQLSLTEIEQQYNQDKIIEFSGHRTENFLPVFSYFELGMGSLFIVMVDFFDEKKDQTCKNYAEIAKLVLDAMDYIFNDWNRGYYYPTITNNLDKYIKKSPKIRKLLEKMKENGKGLFLITNSLPEYSNYLLSFSIGSDWEKLFQIVVFFARKPSFYDSKAQFEIISQNEKSMKLMFGNYNEFKKLLFNSTPNKKEFKTCYFGDHLIGDIKECKAKTDWNTVAIIEELKPNSNDLLESPKWGSFSFCDSSKETKEEKKKTFWQQFADTHSDYYVYSLEEFYDQYCEFLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQX5</accession>
    <name>A0A9Q0LQX5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_05909</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQX5"/>
    <dbReference type="OMA" id="HVIACKV"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5077387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="474" mass="53141" checksum="C643C45D41D243A1" modified="2023-09-13" version="1">MREIIHVQVGQCGNQIGWKFWETICQEHGINPDGQYEGDNELQLERIGVYFTEATGARYVPRAVLVDLEQGVMDSIRGSKMGKLFKPDTMVYGQSGAGNNWAKGHYTEGAELIENVMEVIRKESENCDCLQGFQISHSLGGGTGSGLGTLLLSRIREEHPDRMIATFSVVPSPKVSDTVVEPYNATLSVHQLVENADEVMCIDNEALYRISTNTLNIPNPSYPDLNHLVSSVMSGITSTLRFPGQLNSDLRKLAVNLIPFPRLHFFLIGFAPLTRRDAIGYTALSVPELTQQMFSPKNMMAAADPSLGKYLTASAMFRGRIPTKEIDDNMLSLQNKYQGQFIEWIPNNIKSTICDIPPKGHKISVTFIGNSTSIQELFKRIEGQFTKMFRRRAFVHWYLGEGMDESEFAESQNNMKDLVKEYQQYQDATLDDVFGEEDEQDEVDSQEEVQSGQEQVSGDEDDAQVDDDDGEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQY8</accession>
    <name>A0A9Q0LQY8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQY8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="222" mass="27299" checksum="924FC1DDE35F0FAF" modified="2023-09-13" version="1">MTWRKRASIQNVSNQSLLGLKAALFEEENKKKTNQSIKKKINIFERKNKGIQERNQKDQQKNEKEEKSIEISQQKLKEKTNLYNQFINSTLDISKSNLKEKENFLVDFELKQIQQWKSIGDFDSTKNLVSKDMKREQERRKWEEEQYQELENFERKLKKKEIHEQYKKFVEQIHQNTEMERQRMKEMKRIQKIKRLQKNFKKENQKRVFKIKLKRKSNTNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR65</accession>
    <name>A0A9Q0LR65_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR65"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="132" mass="15169" checksum="C6656FC5CE004DAF" modified="2023-09-13" version="1">MNQQTPKRSKLRKESNSNSNTNILDIHNDSSLKLIPSLKEKLISPKIESNSLPFQSKMNYFLQKDASKQLNINIPSTKKKKKIVEMKNSILYYKARKKWGKNSLMIPRNLTPKSKLFGMISQLGVPKILPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRX4</accession>
    <name>A0A9Q0LRX4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-related protein rab-5c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRX4"/>
    <dbReference type="OMA" id="KFDKGFK"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="200" mass="22568" checksum="D58EC0217AC50A66" modified="2023-09-13" version="1">MDPNSFHEFKLVLLGASAAGKSSIVLRFCKGEFFENQEATIGAAFLTQSVPFDDYVVKLQIWDTAGQERYHSLAPMYYRGSAAAIVVFDVTDRNSFETSKKWVKELITEVSKDILVIVVGNKVDLEHKRSVQIEEAEEYTKEKGLIYIETSAKTGLGISELFKLIAKRLTEFTVGPVEKPSNNTIKITQQTKPPKRKRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSB3</accession>
    <name>A0A9Q0LSB3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein rab-32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSB3"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="23138" checksum="7D44807B530E7E39" modified="2023-09-13" version="1">METEKTELLFKVIVVGDPGVGKTSYIKKLVEQKFNPNEKTTIGVDFQVKTLKEENKLLQLQMWDIAGNPNFISVTHNFYKGASGAFLVFDVSDIKTFNRISNWKDDIDEKIQINGEKIPVFLLGNKCDLESKVRVDLQQFARLNGFVGFDFVSAKKGNNVDETAEKMAKILCENANTPIHEIKIHDENFVDFENPKKKKEKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSQ7</accession>
    <name>A0A9Q0LSQ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSQ7"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="255" mass="30393" checksum="48D9ACE741502873" modified="2023-09-13" version="1">MLIEDENENENPKRKLYSCGDPEYNGLGKNENTYEFTEIKSSLFENDDYILDFSVGYYHNLILTSNSKLIGFGSNNFGQLGTGDREKRSIPIQIQIKLPKLRFNENIYNYHVSCGESKSFLYYSSFSFSNLEEDLIKLFRRKEFCNISFKTENGSIIKAHKLILKYRLNLNQYQNEIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENENENEKYFIIERKEKQYKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTH3</accession>
    <name>A0A9Q0LTH3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTH3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052326">
        <property type="entry name" value="Diff-Dev_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33459">
        <property type="entry name" value="DD-GDCA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33459:SF7">
        <property type="entry name" value="DD-GDCA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040433935" evidence="1">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="326" mass="35658" checksum="8CF2C4D6B7B87EA0" modified="2023-09-13" version="1">MNFFGFLLIFLFLTTFSYQCPNTFAHLGEYCNNSQDISCYDFWSVPTMFVLIKMMELLVKVMIIAHHKFVITVQIPGDSCQINQQCYTTNNCTNGVCQGISIGEPCTNGSTSTCQKGAFCGDFGSGFVCTESINPGASCLAASQVTSSGEEMMNLCKDFRLCMPDETQTGAICGDLFSRDVGGYCSQSFGCKLGLYCQNPSPIGTCQNFAENTVTCSKNDDCPFGTACDCNSATCTQTGNFNSMNEIQNGLSCFGQYHCVFNNPYHLGSCAMSNCLDELKALECAMSTDHKDTFYPPYYWDCKGNGAQSTMILSFGLLIGSLLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTI7</accession>
    <name>A0A9Q0LTI7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formimidoyltransferase-cyclodeaminase</fullName>
            <ecNumber evidence="6">2.1.2.5</ecNumber>
            <ecNumber evidence="7">4.3.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Formiminotransferase-cyclodeaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M0811_04761</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the formiminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.5" evidence="6"/>
    <dbReference type="EC" id="4.3.1.4" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTI7"/>
    <dbReference type="OMA" id="TYGKRQW"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030412">
        <property type="term" value="F:formimidoyltetrahydrofolate cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006547">
        <property type="term" value="P:L-histidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="entry name" value="Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="entry name" value="Formiminotransferase, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="entry name" value="Formiminotransferase, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013802">
        <property type="entry name" value="Formiminotransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004227">
        <property type="entry name" value="Formiminotransferase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051623">
        <property type="entry name" value="FTCD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02024">
        <property type="entry name" value="FtcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234:SF0">
        <property type="entry name" value="FORMIMIDOYLTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234">
        <property type="entry name" value="FORMIMINOTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01221">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="Formiminotransferase domain of formiminotransferase-cyclodeaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="Methenyltetrahydrofolate cyclohydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formiminotransferase N-terminal subdomain" evidence="21">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Formiminotransferase C-terminal subdomain" evidence="20">
        <location>
            <begin position="176"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5078436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="555" mass="61943" checksum="4B809FAB41BA2C2A" modified="2023-09-13" version="1">MQKIIECVPNFSEGKSKSIIDEILSEIKSESQVELLDSDMGADTNRTVVTFVGSPENVINAAFKAISKASQIIDMSKHHGTHSRIGATDVCPIIPVKNVTMEECVEFAKRLGERVGNELKIPVYLYEKAATSPDRVNLATIRAGEYEGLEQKLKDPKWKPDYGEPIFNPRAGATIIAYNVNLNTKDLAIGRDIIFDLREYGRAKRDDKGEIIRDDNGKALTIPGRLKAVKGGVWYVEKYQRCQITMNLVNFHITSMHQAVDEIEIEAHKRGCRVTGSEIIGVVPLEAILEAGLHYLKKQGKSQGVSEEDIVECAIQSLGLSDVVPFDPKEKIIEYKLAQSKSGNQWMNKPIRTFMNDLSSDSFLGGGSVSALLGALSSSLFTMVANLTVGKKGYEKNWEKMNEIAIQGQKFKDWFLEQIDEDISAFNQVISSRRLPQKTDSEKEKRKKEVEQATKNAVLVPFSVLKKASEIVDFIAVALENGNVNALSDCGVSAMCLYSASWGVYYNILINIQYIDDSVWVNDIKPQADDLLKSLEEKVFKIQKDCKTKLEKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUK1</accession>
    <name>A0A9Q0LUK1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molting protein mlt-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6924690at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="938"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1004"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1313" mass="158494" checksum="359A442036702DAB" modified="2023-09-13" version="1">MINLMKEINLMKEINLMIILMKDLMKEINLMKDKFNDRNKFNERDKFNDKFNERDKFNERDKFNDKFNERDKFNERDKFNERDKFNERDKFNDRNKFNDKFNERNKFNERNKFNDRNKFNERDKFNERDKFNERDKFNERDKFNDKFNERDKFNDKFNERDKFNERDKFNERFNERNKFNERDKFNERDKFNERNKFNERNKFNERNKFNERDKFDERFNDRNEFNERFNDRNKFNDKFNERDKFNERDEFDSRDKFNERDKFNERDKFNERDKFNDKFNERDKFNERDNFNERNKFNDKFNERDKFNDKFNDEFNERFNERDKFNERNKFNERDKFDSRDKLNERDKFNERDKFDENDKFNERSQFRNDFRNDFRNDIRNDFRNDFRNDFDPTDNFSKQIDSDLISKKFQNQINSGNPLQCENNLIIESDNSDDNDNDEYFGDLDEEYFNREELAEELFEYHEIIKYQGENYEYSFEETESSDEENTEDWWKTSENPSLIETQKAKNMKDLYYYLLNTTPQNAGKAFKIVINEKDDELFEKFIEMKGYKLFDENQNSFLHFSCNMDSESEKETEFKTKIIQKLISIESMVNIQNRNKKTPLHLFCEKELNIEILKILLSGVVNVNIEDSNGFTALELVLSNNYYSISAKYRYSQELKNQYTQKIQKQALKLLIFSGANLNRKNKLLNNFTPFHIACFSNPSLNVLKTLIKYRCSINSEDINKDSPFHFVCRYFASADVIKYCVESGANLNLANRKQLTPFQELISWNQDPDLISFCIDHGANLQLVTQEENNIFHLFAMSHSSLSIDVLQILIKNSIEIKDQFLMKTNLQEKTPLHLLCQKTSVSTEIFKLLLSIDGIEDVLNIKDKQRKSCLHYFCQNYTDHSILKLFIQKGCDVNALDYENNNCLHFAVQNPIQSIQFLQQLLQNNLDINSSTIYGETPLIIASKKNQNLDVVSFLLENGSDINFTDWKNMTALHYSIPTNFDVIKLLVCFGANVNSQNWKNETPLHYACKKCDLESIDLILFLLENHADASMQNYLCKTPLEIFFQKNLKQKSNPQFQILSSYFNKYNHDFIQEYPFSKEKSLDSIIHNENLERIGPFYFKFVSFLSQVFLDQQDCDVRVSREFCAHKCIIHARIPGFEQSFVENARSLNCNQTILEFLFWIYTGILNINHKQKLLKFSNSIGLTNSQIHEKSGILSVLIDLRHLTVDSKHNPFLHFKKESKPIKIRNNIIWLNHSFYKKIFDSKNQNQLLLDPKFEEMIHEMIGVRTKFLEEKLNSFGFLPMQKIIQDPAFVRFHPVKKEEEKEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVK7</accession>
    <name>A0A9Q0LVK7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVK7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="380" mass="43415" checksum="285D93185E5AB5B9" modified="2023-09-13" version="1">MQLKLNNVNKAALLRKIEEVKEKPQKSLMQTNLTFTFNPRAKLPISAKVYFENGSCHIPVDIPQILGGKERAPYPIDICNYALAAMHMKTFVNLCTFYNITLEKAKIRSYLHFDYGKLYGEKADKSTTTKFGFILSVFTKEPKEKIEKIHELTKQCSPAIYLAQNKIEIETETLITPNSKAEIKPKKHPLNGIDLEKVENFKEKSNESKDKIWPTILEGEWDCEGKTGHQFSARLFYGNGKYTDLFADERSFLGGESNAPSPVQYFLSSVSSCILVHFILLCTQKKIPIKTLLLETQIDKEFAAEFGLEAIPVIRNLSFHFEIDIDQDQSVCDELVRESLLRCPPVNMIVFSCSTENEIMVNQSFPQTFSFEKDKKCSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVM6</accession>
    <name>A0A9Q0LVM6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nulp1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000049">
        <property type="protein sequence ID" value="KAJ5078690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVM6"/>
    <dbReference type="OMA" id="HINHHEL"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="793"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="827" mass="97939" checksum="AA9ADB3B268E4FEC" modified="2023-09-13" version="1">MNEQKTIILQEKEEITNEEDLSNNQNEEITEQLQKSKNEENQCISSFISPEKRNIIINKIKTFQCLPEKKVITIRFLVSDGIINPKLSIDDLLQSIKFIKELFQEKIIDEDILEICLKLISNLIEKLTQNLVENMNLDSNFLKLVNNLCLTSSENSSMVHLNEMKSQSLSRLNSIKTDEFIQNKTQIKFQKQRIVMNSEDDMIKNSNKKNQLYFNSELKYLNNQMFQNFHIPERDITQNDLYIDKKIMINDRSMLIDNVSKNENENEIENENENEIEIENENENENENEIGIENENVNENENENENENENENENENENENENENENENENENENENEIENENENENENENENENENENEIGNENENVNDEDEIGNEIGNENENENDEDEIENENENENEIENENENENENENENENENENENENENEDEDENENEDETENEDEDEDEDEDEDEDEYKTEDEYKTEDENENQSQNQNNKKKKHKNKKEKNKKKNNKNKKKIPRRKTKRRSTKKKVKVKVKNEKEKEKEKEKEKDSDRESTNDTTDYSSDNSNSSDMEIDNDSESTAEEEKSDSENDSDVDLIYQVPKKELRKKGSRCRLCGYVKEEGHSKKCRCIKRMKRRKTYLIFIKHTRGLNCKVKKRHIYHLAVKHINHHELESEIELHENNWPFYLNKKRSKRIAEKKIKSMKKENKIINKSKSNKEARKNLVSSRFKLLSEDPSVKTSIFHNQKKLSSKKKSKAKAKAKSEQHKLDSKKKSTKKRKERQKRKKDSTDSETLKIANPKRSRSKRKSKHISTSSSESSESSYESKPKSKSNLNLNLNLNLNRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVR4</accession>
    <name>A0A9Q0LVR4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000045">
        <property type="protein sequence ID" value="KAJ5078750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVR4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="142" mass="17191" checksum="42C0382A5F544F40" modified="2023-09-13" version="1">MGRSVRSKRRRSNKRNLEKKLQPILDEQLNTLVDKFNKSIQKQEEEEKQMTEEPEEEKQVTKTHKMKEEKMTAKDSLVNLIEIKTNKRLVTNMKNQQKMSELILKQRLRAIQKKKKQQNREQKKKMQFKIENSNQDLIKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXQ0</accession>
    <name>A0A9Q0LXQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Repeat outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000002">
        <property type="protein sequence ID" value="KAJ5080752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="536686at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040132522" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="928"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="4">
        <location>
            <begin position="788"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1590"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1533"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1601"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1626"/>
            <end position="1645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1645" mass="185986" checksum="6CF5FDC65F61FCB7" modified="2023-09-13" version="1">MIKFYYKKIIFLIFLTIISQVFSNEINIMPGQSIQAAIDSAFTGDSIVLYPGFHLTTTLDFGSTNATQLTLKGRESVDLPTLTLDCGASLCPSDSTNQLFDLVQINFVVKNLKIVNVNRLANFEQANVSIQISFVNVFFQQIYSTANVSFLELSDFDTHSIVFENCTFQNIYTGPITPSLIVVKSNNFNMTDVLFQNNSFTSQAAYGIQVNINNTNANAQPTFNNTNITSLEIEKGNIYIMPGTMEIAKTFSWKQGKISGKQFEYTEIRVKQLIELTDGTDTFNYTQNARWLDSMKVFLEPNGRGSWTGTNGLTMGWESTVYLSSGTMFTIDTTEENEGTTPHPCGNICSGNTGNFTVGNGSHLVFFSQLPNISVDPNAKGFVVSGALYVEPEGAVVVDKGFLTIHGEFAISGISWNFSGSILNHGIFEFGDESTGIGFENTTEQNDEVAFFNFGTIEVVDRVNKLQINSSMVNADKRAEIIIGEDQELEVFSLETKYIYDHSDTILSSHDYDRSPYIFIENGGILRVLTGMLMDQGTVRGVGVLEADIVNDGGCLWGGVDWTSPLYLDFGTLTVQGNYSQTVEGMLRSRVYDSTHFEKINFTKPGSSVAIDGLLDFVILYPFVPEVGQNFSIIQNGSDSVTITANVSNVPSQDSNNSNYLDYSERFWRTVVDEGPTSADYNPYSNPRQNTSANSTYPYYYEKELDSTDTPYQDYFKEFEVTVNDSQIFISALGCAPGKIQNNQSRFCTDCGRGTFSDTFAAEVCTDCQPGSYSSAVASRACFICDPGSYSGLAASECSLCPVTQYNPISNQSSCIDCPDPTRTADKGAVNLTQCLCKPGYYGVVGDCKECPIGGDCSQLGMIIPLSAAGYWNRSADEVLFFPCVPRQACTGGGNCADNYEGRMCGECSDDAYRLGSFCYGCEPNAKWRIAIFVLFFVFICWVFYQLASLGSPPPLYLAPLTILFGFLQETALLSFFELNWSDSVVRFFEFLSISSLNIDLLASECYNHHMGFTEKFVVALFLPLFVAAAYYLYYFFASLWAYFIEPRAEKLRRKWPNVFDLTSTFSTFGKIRRAWLKLMRKLFHFRRMEELYILAKNSVNAFTFSLTFLYIPLSLWIMRSMDCTRYEGDFSVFDPEPFRACSGSQYRAVLAFGVIFFLIYVFGIPFGLIYIMRRFKSRISFREEFGLIAGRFADEVYLWESWIFLRRFLFIIFALFMSRYPMMQAAFVEMALFVVLLLQLYTRPYKIARHNRLEFVILIIRVLVLLGGTLFYGREFPNKPTERLLSSFVILAVLSAVILIIFAIFYDRKRMRALAKDRALELAELQNHLQSQGLVSPNSVPVAGKRVWNTAEVLHFLRDDSVPKSIFPWLLNAEKEDHEDKKDEDKKDEKDEKDEDDKKDEKDKNDEIELDILTGDEKDKDDEKDDEKDNDNENEKEKEKDKDKDKQQENLSHPQKCKILWQDDILPFASNALLYWLKDARVLDKRSLSVLFRSLEKYSKKHGKPPTKKKFKSKLKQIFRKNKKENSDYESSDTSSYTSSNHNSDNDNIDIDPSTLKNIPPLNDEIELDENIIPPPDLKDFDIDETIVLPPPIIDDNDDNQNTNENNNNNNNNNNNNNNNNTNTHQLVPTISQQPLISLSSDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R448</accession>
    <name>A0A9Q0R448_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ring zinc finger-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13703</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R448"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="224"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="285" mass="33136" checksum="2D73F011E7779FBE" modified="2023-09-13" version="1">MSSILSKCLLYDSKEALYSFRFFEMIMKEMSLEDYLLSEKNAIKHLAITFVVQEIENLIKINMNATPLLDYQKKGMEFFDKLYPQLLNQQPCQSIQSNFRNLSKKAQKKIPKEGIQCSLTRGNHTQEHCNTDYCVHQGGKFMRGLKAIFSKAKPISWKGDFQFPETETQSKKIFSETILNFREFIEKSNNLQNSLQQIYLQYAILNKEINDHHDLRSYLPNDTCSICFHPAQEKRLTCGHLVCEKCVKIFGNLPDLIESNLNNETIQNPIKFCSYCKDKVGVQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4S0</accession>
    <name>A0A9Q0R4S0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ybak/aminoacyl-tRNA synthetase-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4S0"/>
    <dbReference type="OMA" id="HIDWKLG"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04332">
        <property type="entry name" value="YbaK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30411">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30411:SF4">
        <property type="entry name" value="YBAK_AMINOACYL-TRNA SYNTHETASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="224" mass="26155" checksum="AF86B7EFD5553E08" modified="2023-09-13" version="1">MDSRIEFAEQRIKEIEEKLKIKHEIEVTKEDEKILEKIPEKVLKAIKEKKMKAKPKYVPSDYYEKTLEKRSKILNAPSINHLCKSIILENIHYEKNLEENNLLNQKKEDELLNAKYFLVLVQYSKRLNFAKIANFFRSLLKDEKRKFEFKLAPENISFDLSGFEHNAITPIGMNVDLPIIISDSICALSPQFFWMGGGQVDLKLCCSTLEFMNIFHPLIASITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R545</accession>
    <name>A0A9Q0R545_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R545"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040386652" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="137" mass="14885" checksum="F8582782B741116B" modified="2023-09-13" version="1">MKKTIKITIILFFSVMVCLNQAPNSISKPELLWSYVGCYSSWCETGWYSSPALLETQGKIVAASYSVWMIDGATGNIEWTAAAGHGSNEPSASSVGRTCVMDLNGIMKPGFPKQVASNEIRSLTVADFNGDGYYQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5Q4</accession>
    <name>A0A9Q0R5Q4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5Q4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="232" mass="27674" checksum="B02D7C88DBBFD056" modified="2023-09-13" version="1">MFQIKFLDFHFSGIILPIYLLLFIGWFFVLIKTIYQALIGLTAFQCFDSLKFFLIILRLLSIFLNILKLITQRFSSFSFFNIFLSNFPYFFMIFGVIFPLKENVPDLFFLLIITFILIQLIGCFVNILIPFRMTSSPLFRLLTSTQTFMSAIYNFICLGFYIMAFLKFQEKEYLKIYLTETFSLNYSYFSLIVGIGFFLRNILRIINISGRRFRNEGEVRNQREVKNEKKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R739</accession>
    <name>A0A9Q0R739_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btb-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R739"/>
    <dbReference type="OrthoDB" id="6678352at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="296"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="485" mass="57327" checksum="8C182F24C3CE1696" modified="2023-09-13" version="1">MENYLNLEKLSNDLKNLFQNQNENQNQNESYFDFEIICEQNEISFKTHKSILSSRSHYFKSLFNSKMKEYQENKLILKDVSSSILFPILNYFYSGKIEINLENAIQILIFSSKYLIDELIEASSKFIKNNFQFETIVDVLKLSEATNLNQLLDSSYQFILENFEEFIKTSFFLELEENHLNSILLNDDILINEIELFQSIIKWGKHKSNINQQKEIEKEEKEKLQNQISNVIEKIRFIDFTKQELKDTLKEDLIPNQISQKLIQFQKLQKEKELKELIQKENSLIFKSRFGLNTSKIIQNEEYVKKLQEWINDNDFFSKMKKGFSAKRDGFDCEEWHKTVDEKGKTLVIIKTKDNFIFGGFTSVGFTDDKSKWRKEDQEEQYGWIPDSNAFIFSLRNDKNDRTPEKFPIRKDGEEYAIKYAFSLGPIFGGSFDFYLNGTLQPGYSDFGFNYQLPQGMSYNTDEAQSYLAGSRNDWVVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7C0</accession>
    <name>A0A9Q0R7C0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_02521</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7C0"/>
    <dbReference type="OMA" id="HIASNFE"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF2">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="15">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="48"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5068579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="480" mass="55115" checksum="5DFF1C2D19A085D0" modified="2023-09-13" version="1">MKNRKGKGKTKVTKMLSSDLISKPYNFQHVQHVDFDYKWSGEDPESIFTLEDVLGEGSYGKVYKAKHIASNFELAIKVIPTQSFEDSETKNEIDLLKSFKNQSIVTYFGTLFKDNNLWILMEYCSGKSILDLMEKLEKPLSEEQAGFVLFSTLQGLVYLHKNDIIHRDLKAANILLTENGKVKIADFGVSKKLNSHSSQTLSVIGTPYWMAPEVMKGQKYDFKADIWSLGITAIELVEMEPPNTDIHPLRAMFMIPKMEPPNLKNSSNFSKPFCDFIQKCLVKEPSKRPTTEELLQHPFFKPYFQQTKESPLIKLLKMKPKKSKNEKIEKKTFLNKKTQQTIISIKQTTKNNQEDDEDDEDDGEFSGTVVRYPTKSTKNSPQVLPKIDFHKNSSKTIAVSKKTSSLKKKNEQNKSIKKSSFPKKPKEIGRYLKTIVVTPENKINWKSIFTTLFGSLILTRLDLYGWIAVLIFLIFLYLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7V9</accession>
    <name>A0A9Q0R7V9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7V9"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="715"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5069718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1230" mass="141717" checksum="40E1215EE630A2B9" modified="2023-09-13" version="1">MEDKFQSQLMVISFGELLKIAVQKSYSNLRNLQQKMQNMRVGERKKQLTQYLSKTRMIFLEILIIERWSKSSVGKIEEVIRILRDLESFAAVPNHLYGIPRGLVPRLKQPKYQVVDAINVLKGGNSETCPTSLRCFVPIKITKEEIEIGESFLENVLGSFQKDALGFNVLERRGNRLVAMMNDEFEVTLEIMVMQSAVKKTTTCDPCGKSGVLDCGENKHTEMQRMRFAWRLTKIEFFVEKNLTASEKLKNLIRILNKHILQAQTTNKYWDGKVHRGGKQTRKEQEGDESEQTVARYFWKEEILKQNGRQILVYLHDICRSCCLRIQLELLAEHAKALHTISGINYEVFRTSDSLAVRYWRGYYIRYQIVEHAMHISHFPVIKIDLKSGSSREIFAHNLVSCVQFFRKKKIHSLFRSITNAGIFSTGFSLTIVSKNENENVCEKSLSQICTLVADAPRLELRSTELQIGVDVSVDYKKGNFVVSSKHSSPTPVFTRSVDTEMPRALAIVVELLQEEILVRFDRGFRGLGLEPFRSIPITSKTKNIIPEKVACLFLRFPNTREHFLLLTIDAHLSPSIHLVAATENPSSVFELRQLKPILASPVVALNNQIFKKVGDMFPKLCASVQHLVIDRELTRNNISHLLLPDAKINLKPSDVVRHLGIAQLNVNLTNAVVQIIGAQSLEIVMCLRDEWARRLLALNLPNICYASDSPGEQSDTAYTQISTDSPQNQPLEVDLDPSQKDPPFFPETPSKTPSLKKDKKKKKKRKIPDNIIEQDPNSTIFTSSTAKIRNSKISITFRRMTHLCIFQNFKDLQEIFRITHLYSQILNHSLSRRLLVLLLKGTTISIRRQQNLDPRHPLHMTIKWSTTSNEYRIAMDPFFAMQYQIQDMLNAHSDNFPSVVQALLTSYDTCRYMCNFASFRKIGTVLVPRSISMAKLVFRNRLSLEIHFIRESLIGIEDCSEQLLRFPMLLKKISANLKSANKEIYNEFKSYTSFAVIPIELLETTMFLLYKYLGGMLIFQELKHHLVGHHENDVSIRADLQNHQVMITFTENFDVALQFTSGNQFLSKHDLTTLSTYFETHLAGEPYDAEKPKSFLEFLRKTPIDLLKEFVWLFSRVSKDNSTIIDLEFKPPVNRCAVYHENNLLSFSFSCLWTIDSKKYQLSIPVEYSYQQNKIKMLIEDPQVYHAVFNGINQNQPRKDWNQSVFYQVVNNLDKLSPENVLRLVPKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R866</accession>
    <name>A0A9Q0R866_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R866"/>
    <dbReference type="OMA" id="LYSEYHE"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040357650" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="259" mass="29820" checksum="D95DAEAE3038DE44" modified="2023-09-13" version="1">MINFLLYFCLFSIIFSLPVNFDWRNINGISYLTAIRQQHLPQCGSCWAFSTTSSLNDRIKIKRNNTEPDIYLSPQHLLNCAPSVGTCYGGYVWLLMPWIQKNGIVDETCSPYQAIDKECTPINTCKQCFGFNKNCTVIENPTKYYISDWGQLNGEEEMMNEIYKNGPIVCGIACPEALDNWDQGDEIFYDKTGANSLEHWISVVGWGHDDESNLDYWIIRNSWGSQWNKKYGGFFNLVRGINNIGIQKWCYYGNPIVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9A4</accession>
    <name>A0A9Q0R9A4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9A4"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="38"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="561" mass="65530" checksum="3AC36F7940F4705B" modified="2023-09-13" version="1">MNEKRNLSESRLIIKKFTATEAFVSDLVLSIEIPELGQDVVIEAKNHQKLYGYSSILSSRSPTFAAFQSNHLQLEYDYKVAKEALKYIYTSNCDIPVIDSNQKEKTPFDLTCDLFSLAKDWNLYEVKFWCEQYILSEIEKTKRDSNDKSSEIKNQALRKLDSIVKLNQENLLEKVLSVIDKQIGDIIRNEDYLHISDSNLKMILARDTLNISRELSLFWMIVSYAKENFQDPKPNQNGNSFNERIKEILKQDLAHFIRFGTMDSDDFLEVQNFELLTDDEIDDISDFIEYSSENLDEKTKEIIEKYKAKANENENNENQKEKEKNKEKEKEFVHWFKSKRVYIDPNLINSSGIESEKNAKEIKPKNLAKTEGIVDKYSAIVQGWIWKNTFQKMKLQFISTKEDQLTCQDFHQVCDNQNPILVLIQSGGNIFGGYSSVGWKKPEKKKETNEFDINNYFNQVNYIEDNQAFLFILKSSQKDQQIKIELKEKQKKTAIVYYSQRGPIFGDGWDLSISEDLKTGYSNPGCSYQLPNNIQFGSKEAKMFFTQQYGEWKVDQLEVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9H7</accession>
    <name>A0A9Q0R9H7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Seipin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_10256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9H7"/>
    <dbReference type="OMA" id="YSASIQM"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="406" mass="47621" checksum="15B21AC7C8E8089C" modified="2023-09-13" version="1">MSSLFFKFLFSPIQKIFNQITNILSSIIHKIFDTLQIKKNLQRLLNFILTIISFQVRTFIRITIIVIIAISFLVTSIIIYIIFYRAYVPYIKLSAPVYFQYYNDKPYAELDLFEKFYQKKDSTGSVLRRGQSYTIKNTIILPTSPHNLDHGIFMLNASLLSFGNSLISSSARPYLMIYSSPFIQKLKVFVLSFFYLIGLKKEQQTLVAILYENFIENKNQPLSKIIFELSNSTVNIYSSKIEFIANLKGFRYWCYHWFFSSMFIGVIVIFFAQWFFLILLLVFYKIKVYQTKLDSQVTEVDFHFNIPKNNSEKKKKKINNFSNLKNTNLDLNDNNNNNQLINTNINRNNLNNQLINRNRRNINDNNNQILNTNTNTNTNTNTNTNTNTNTNTNTNLDLNNNNNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9J7</accession>
    <name>A0A9Q0R9J7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9J7"/>
    <dbReference type="OMA" id="LHKFAQY"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="44"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="558"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5071966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="845" mass="98608" checksum="227740C493915E1F" modified="2023-09-13" version="1">MSQTRSAHLYEQQFQCSFISSSDVTQSVSIKIKKIQGTIPKKTYPELESNPFLPFSNIYSTKPSNYFVQAKLYSAGKPLCSSQHTRYKPIDDYSWYENLEFPLKYCDCPLDTVLVFTIYDLFAPRANFIIGGTSISLFKDNSRKLRRGEYHLLIYLNKKGDGSTKIETQGLIPKTEQIGRLERSLRRHKRDIFFQLKPEVNWLDTSIMEKIDEEFDKYSEEKKRIFLLVEFPTFRKKIILNETMKYYPQMVIFQEKFQKEPLPPLSLLSGSSRVENDCLWDPEMFKDNPVEMKNRKLSRSRRTGIDRNLKPNSEEIKTIEAIISQPPTKILTDNEKELIWTYRYSLTKNKKALTKFLRCVDWTDKSEEKQAQELITEWAKIDPANALELLSSFFQSPVVRKLGVDRLREAVDDELLEYLPQLVQAIRYEKNPITSDLTTFLIERATKNPILGSYFYWYLSVETQDKEYSNMFTNVLASFKAENAKLDPDGMKMLQRQKEYVDDLMKLQEYIKGLKVSRTKKITKLKQSLTLQQQFLKLNTFDPVRDPLNPNLKISGILPETCHIFKSALQPIAFNLKLNNTEEIQNYGAIIKLGDDMRQDQLIIQMINLMDKLLKKEDLDLELTPYKVLAVSNNFGFIEKVPNVKSVAEILKKYKTIRNYFKKKYSNVYSDYGNDEKKIIQNYVKSCAGYCVITYLLGIGDRHLDNILLTPDGHLFHIDFGFILGRDPKPFPPPFKLSKEMVVAMGDRDSEEFLSFKKYCCEAFNILRKSANLIINLFSLMLDANIPDISRDKENCLMKIQQKYQLDLSNEDAVKYFQELIHESYTSLFPVIVEQFHKIAQAFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA31</accession>
    <name>A0A9Q0RA31_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA31"/>
    <dbReference type="OMA" id="FQEAGPY"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="88"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="418" mass="48956" checksum="8180E6665C9FC62B" modified="2023-09-13" version="1">MNKTQEEENEIIQKIRSLNEKERKKIERESRNRAKRDLKIKIKKEKEANEKEKKMKNLKTKWIEVLTTVKSTENIRNYKSIQNLCFQGIPPSIRGTIWQNLIPNNLHITLQLFNSLKKEAKQTLEKLEILNQNEINKWKQSNKLQDSNQPIESPSNQNKPHKANGNHKKNNSLDQGIGDKTSIVFGKEDSITLISLDLPRTFPGLKLFKENGPIYGFLHDLLGAYTRYRPDLGYVQGMSYLAAMFLINMDPFPAFCALSNTLNSELMINFYNVNMRFINQRILVFDKFLQKFEKEIFNHLRSLEITSELFLIDWFMTIFSNVLPLDITSRVWDCYFFFGEPFLYRTGIAIIRLLKNNLLNHIFDDCVKCLLSGFQSISEDDLFQEISKIKISEKKLDKIIKLTIVPEEENSNQDDSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA68</accession>
    <name>A0A9Q0RA68_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fam11a b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA68"/>
    <dbReference type="OrthoDB" id="10258440at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="566" mass="65348" checksum="8EDD3A5B2E132845" modified="2023-09-13" version="1">MQNKLPYIIFENKGVVQITDNFYNSIFYSAKQETTEKTQNPPNEEENLISKLPEEIIYSIANYLSPVEVLLFGQVCSAFYDISNDDSLWRNISKQFNQLFVCDPIQVKMVLLDEVYQYEVIGFQTNLKEKIKKIQNKILKNSNEIELKSRKNANFADEINAFDQNLSQSLNADLYFNSNLNHKEEEKKDQQKKYEENEENPRQKNQRGGFFSVFLPKGTNNNDDGTTTLIDGKTVAVEINEEKTINEYLDHISNPKKKFLKKIKELKPQMEAKKAEENEQQNLERRRLKFTKIEDSLGFSALSFTSLWIVGLCISVIMIYLKIHYQFSISYGSIFMSSWIPLGIVGLLVLLFGVLDNPNRTSTRSDECGISITWAIFVWGFGLQFALIGLKMDAKISSNWFTVFSPFFVFWGLMVLGFLGVQCDGGFSGRFSCLNFFFEFIWVVLLNLFLYFLAAKLNHSSNWNYAKVFSPLYILYSIPILGLIRGFFRGISSDFFLLSFGFFCLFLPLIIFQILLNLYLDGSSISLSSVFIPLWILFSFLIFLGLIGFGLSLLKSIQSFKFWLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCA2</accession>
    <name>A0A9Q0RCA2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCA2"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="497"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="830" mass="96365" checksum="A59C4A3E5C797017" modified="2023-09-13" version="1">MIEFFISKGFDIYSQTKFRFSPLHYACKYNSLEVIKYLQYKKIDTNFEVIGNETILHLACQNRNEDALEIVKYLVSKGFDVNAKTNFGISVLHSACKKSNSVEVIKYLTEKGAYIHAKTLSYKTVLHHACQNKNEQSIDIVKYLISKGFDINAKTDTNETPLHYACNKNNSIQLIKYLISEGADINAKTHEHETILHFACQKNSIETIKYLVSKGFDLHDKTTENWTTLHYACCSNTFDVIKYLVRKGVRVNIKTNNNQSLLHLACQNRKSPFQIAKYLIEEGVDIHDKTNFDQTILHLACENRNSSLDFIQYLIKNRVDINEETILGENTLYTACKNNLSFEIIEYLIEKGADINSKSVYGETLLHIACKSKQSFRVIKYLVEKGVNMNAQTIRKETALQFACQYSSLEVIKYMIEKGADGQVQNKRGQTILHFVCRNVNNSIEIMEFFIKKGFGINQKDIDDRSILHSSCLNRNSIEVIKYLIEKGADINAKTQFDQTVLHLACQYRNSIEVIKYLVEKGVDINAKTQVNQTVLHLACKYKNSSEILQYLISKGVDINAKDAFENTPLSILVEKKNQKGIMLLLMNDADMYDLEKEEITQTFCDLFLKIYSLNEDVYQLFTSEDNFSDYQIKSSDYFQFNVHKFFLLTRFDNNEALLQKFISTYQEKSKEDVQLVLNFLYSGFHDFEQIKQALIKQSESSPQPPRSKKSIFIPHAKNETKNPILRENLANKEAIEEFFQGMGFDSNWECFFLSVQDSSNKVHDYSRKSLETINQLIYFLYHDEFDKEIHLTNQIIEELEDVKDYYQLNQNSIIDLILEDEFYIFNEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCT6</accession>
    <name>A0A9Q0RCT6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCT6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="403"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="481" mass="56431" checksum="B6C30BCAA2ADA149" modified="2023-09-13" version="1">MNEIIFFGSNLKPKLIKNEPNKITKPIQFKFENENENENEKQIKQISSGYNSIIFLFENGKAIEYLNEEDSNENPSKIQIKNIQKITIGWQNEAILTKEGNVFRHISYSNPKNPNEFINISSLIEDTNDRIIEDIVSGKYSIYLLTLNQNVYGIGSNYFGQLGFAYKNFQYTEKPILMMKNVSKIFSGNSSYHVFLLNSNQELFGCGDNHWGQLGLGYTRNNPKINQNPKYSKRKGKLIGFGNNNYGQLGTGNTNYQLIPIQIELPKLRFNEDISNYHISCGYNKSFLYYSPPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKKIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNEAFQIFEYWIYSNQIKDEIQITKEIIQNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDD8</accession>
    <name>A0A9Q0RDD8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDD8"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="255" mass="29468" checksum="5EC744079EC8E2B6" modified="2023-09-13" version="1">MFEIKKIPILMMKNVSKIFSGNNSNHVFLLNSNQELLCCGDNFCGQLGLEESRKEKEIKKLTKIQNIPKGEIIDIKCGSSHSIMLIENENENQNPKRKLYSCGNSQYNGLGKYKDTYEFTEIRSLFENNNNILDFSVGVNHTLVLTSKRKMIVFGDNDYGQLGTGNTRSKSIPIQIRLPKLRFNVDISNYHVSCGYNNSFIYYSPFSFSNLEEDLIKLFKRKEFCNISFKTENGEIIEAHKLILKYRLNQNRKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE41</accession>
    <name>A0A9Q0RE41_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE41"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="804" mass="95806" checksum="A79283B4E678D62B" modified="2023-09-13" version="1">MQTNFGSKVNNTISKDSRIIISFFKKNPEKDLSSFYIQQQLAIPISYFPLLYNDINSQLAKEEIQKEIQKEKEKEKDREVEQFMVTLLEDNNKFQAILSFNPEFIEIKYQDETKQNEKLYLQEEKIKMIIHPTKKNRIMFWKNTNKYKIIILEKEETRTAMVNSFIRLTAPKTAPFSNTKKVKNIYSNFKNAFLNFMASFPQKIALEPEINAKRKDPKAKSLFCRNEDEEHIIYSQKMDFENNEDYDQENEIINQELQPPKSTFYEFELMNIAHFEEEQKVKISLHQHFFSIEFKNTKIERVYSIYSHLWSAMTPNKSNTEFRFHIDEYDFILIRLPNYETRIGFFFDFYSKRDESIRYKQNQEKSARCKMAHLGETSDVKIILYRDYFLIKKKKEHYLSAEYTNETKIIKKKDANLILQFGKYKEILLSFQNSEDAHEIMKTFQTSKILFLMYCRSSNNENIFFEYLVYNHIPIGFSSIQIFPDQKFILQPDLHYIKICLESEENPKEERMVIEYPHFCRMKIEIDRIFDVYFAKKESRETFLNLIEKNSVKKTIHFFIGFPGNFIESPEKNVKITGEILGSKTKSLIIISQKEKEPKALNLSELQILSNSNNPFLIKIQLKQTQAQIFFLFDSLEIRTQFTEFYQQNFKSLEIGNEDNSRVNSQQDNQKIIYKISFVNAKAQVLCEGFLELGHEKILKIQKKNQTIQRKIDYNLRILCSKKDPVFARIILTFSNSHQKSMFIKFETSEEASLFYDRFATIRNLPDEQNLNQNLNENLNKNLNQNSNKNRKSKSKTKSKTKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE56</accession>
    <name>A0A9Q0RE56_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor 3a subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_05843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE56"/>
    <dbReference type="OMA" id="EFWIQIM"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5077321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="244" mass="28585" checksum="DB4D30005BE9769E" modified="2023-09-13" version="1">MSEREHGSKPGVGGLATTGAEYVDRRERLRRLALETVDLSKDPYFFRNHIGLYECKLCLTLHLNEGSYLAHTQGKKHQTNLKKRAYMQAKDSNQGIVPKNKPKQKQKNIPKMGTPGYQVIKQIEPVTNQYSLLFQIEYPQIEKATKPYYRFMSPFEQKVETPDKKFQYLLFGAIRYETIAFKIPNIPIDRREGRLASFWDSDKKMYTLQAFFLNSLPQNNDQHLEFKNEEISNSITNERKRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REJ5</accession>
    <name>A0A9Q0REJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molting protein mlt-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REJ5"/>
    <dbReference type="OrthoDB" id="1585644at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="539" mass="61023" checksum="BE5B6FA88A2D51EE" modified="2023-09-13" version="1">MKSLVDLERIPENFSSEQSLKLQQQAKKGKNGNVLHLYAYRQNKTKLKRMLSEQKYEINKKDKMGNTPLHIACFTGGPKIFKALLKHGADIQATNKNKETPLDLAMLSNYDKIKKKLVEINAPHNTDISKLQMHIIRGENSQALEMINDPKHRGLITRADKLGNLPIHEAACYGMKDCLLALLQHNSPVDPINIDKRTPFYLSCLNSQLECAKLLADHGADLQKRNIYGTQAIHTAVSKQCKDDNILAFLLQKNVDPDSRDGEGMTPLHLATNPERVKMLLHFHADFNTLDSFEFLPVQYMARKGAFFSLQVLVEHGAQIISGEMGFPPAHLAARKGHHKCLDYILQIAKKRDQMFDVCDGWFFENSLIAMTVINNHPKCLRVVLGHSDPGIVSAPEAKKTNFIYLAMKHNRAECANILIESGYPKPPLSKKEINKLSAEFRYLLLGDFSFSKDFEWLFTSGSFFSDLSVVVNDQTGILSPLLRSPRKTRKARNPHSSSTLQRRSSPRCVPSPILHIHRRSFAIQNFPQKNQKAQAYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REK0</accession>
    <name>A0A9Q0REK0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REK0"/>
    <dbReference type="OMA" id="MVNQIFL"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="36023" checksum="BA6A12EEA1456390" modified="2023-09-13" version="1">MEYVELNTKQKMPALGIGTYRSPKGELGKAIKIALETGIRHIDCAYFYENEDEIGEVLKETFDQGKIKREDVWITSKLYNIFHDPKDVQEGCEKTIKDLQCGYLDLFLIHWPVAFAKRDNLELFPKNDDDSMCTVDVTLIETWHAMEKLVELGLVKAIGISNCTKEKIDEIYEKAKIKPAVNQIENHPYLQQEELCQYCRKLGIQITAYSPLGTTDFKQENALLLKDPVILEIAKKHNASPAQVLIKWNIQRGNAVIPKAVKPEHIKDNFECFKVKLTEEDMKQIATLDRHLRFVNPMYFWNIDVFGEANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFA6</accession>
    <name>A0A9Q0RFA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hermansky-pudlak syndrome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000051">
        <property type="protein sequence ID" value="KAJ5078671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFA6"/>
    <dbReference type="OMA" id="DRICKQY"/>
    <dbReference type="OrthoDB" id="10255234at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026053">
        <property type="entry name" value="HPS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761:SF1">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="336" mass="39532" checksum="553401D5F9F027AC" modified="2023-09-13" version="1">MRVLIDALINLSNNHQHFLVHAVHKIEKQNLAETIKEKLLPIIQENESIIQILFFKIFSLLLIYIHAVLDYEQLTSSEKFDDVPLETSENESVDFSNEIPINDCDEELYFRLPNHQPLRVYSAKTTSNTKLVLILRQNSSLSTENLREIAHRFRYSVRHHVECLSIPSFTILPYVSKYPGIIHFIFVDRNRNRVIAPDFTSLHEVYKIETPNIENMSKNYIKSKVWDLSSHAQTFLEKGFHSMMMRVGPFFYCYRMWFENKEGEKLLINEKLPSLENLSQENSFHIQTIQKLFRSKKVYCYEIYTLYSAALSSETAANFNNCLISDLFSYFMDSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFZ7</accession>
    <name>A0A9Q0RFZ7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000049">
        <property type="protein sequence ID" value="KAJ5078687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFZ7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18370" checksum="D8DDDD13E7E50B04" modified="2023-09-13" version="1">MKKFKPQITIDGYPFSKNRHNSTNTTGWYRCRKRCGMTAKLFYNPNLQCTTNGQHKPTCQRISQSREVADLWNLVEELALDNIFTPDRVYREMCVRIDSDLEKAYITPSHQEVKNYVKNIRLPSGKKKKKKISRISNHQTLFQDRFSQEVEPNVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGK5</accession>
    <name>A0A9Q0RGK5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type E3 ubiquitin transferase BRCA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_05539</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGK5"/>
    <dbReference type="OMA" id="TEEPFEM"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031099">
        <property type="entry name" value="BRCA1-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="609"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="132"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="329"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="435"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5077849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="914" mass="104006" checksum="BBEDA7CDD3BCF8E7" modified="2023-09-13" version="1">MEKLGKAFHKIERDLVCQICRKPLKKPRSLPCHHIFCKICIDNATKSNYVCPLCFMPFLRSDKKRVHMLEGIMIQVERLKLAIQNHDNNETEIENEIETNKAEIETNKTEIKTETKIENEIKTETEIKNEIKNNPNEIKNNPNEITTEIKTNTNNSPKKNKKRKSDTSIALESQKSKSKSKSKSKSKSKSKSKSKSKSKSKPKSKPKSKPNKSTSESEVESESEIESTSISEVESQKSKSKSKSKPKPKSKSKSKSKSKSKSKPKSKPKSKPKSKPNKSTSESKSKSKSKSKPKSKPKSKPNKSTSESEVESESEIESTSISEVESQKSKSKSKPKPKSKSKLKSKSKSKSKPKSKYKSKPKSKPKSKPKSKPNKSTSESDVESTSESEVESTSESEIESEIESTSISEIESTSESEIESEIESTSESEVESQKPKSKSKSKSKSKSKSKSKSKSKPKSKSRSKSKSKSKSKSKSKSKSKLNKSTSESEVESTSEIESISESQSQSQESQSQSQESESQEFQPTQPYKKIKTLSNSPKIQNLIKSNSIALAQFLSTRSPLRKTPSRKLKILQTISKEILQNSENKTQNEQENINNNHNHKIHKIEVKSQDSKPNQEIITIATSCLTEKEMQTIQRVVKKFNWKFVNQITCFSREPNQPNQNQENTNIKQTKITHLIMPYKRTNLAERSIKYFLAILNGVWIVNFEWINMCLKNNAKADETQYQIQGDPYYYGGSIRSRLLISSRLLFKNLFVFVHDDYYSEAYPASHILEKFVIHGGGKVIHKNLHTQEFRLIYNQDLLDHFSDEGNDKSLMEIDSSKQEQAQKLLDDFGIVDNHQIYCEKLKKTLIVFTSCGCRKKKSLQAFNYYLSSLQNESQEQEDTKTIYRFANISPKWLLDSISNFGLISIDDYLIRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGN1</accession>
    <name>A0A9Q0RGN1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGN1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="109" mass="13002" checksum="1093703682800300" modified="2023-09-13" version="1">METQEIYQILQDLNKLAKWDEICSLFLIFSEIVSPNIQIEKIGEILETLQEITKKEYISSQVHYWAISSLEKFIHQNLLTQISQSFPDLDIENILYHTHKFCIFFSNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGS6</accession>
    <name>A0A9Q0RGS6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGS6"/>
    <dbReference type="OMA" id="NEMVRHC"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5079434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="90" mass="10668" checksum="FCC270B2E46D20DE" modified="2023-09-13" version="1">MGSSTSKAETQKIQELEIQDYIQQINSLIENCFQECVCSFRTRDLNSSEKTCLKNCVERMLSFQKRVEQRIAEQGIMAQRRFEEEQLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH56</accession>
    <name>A0A9Q0RH56_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorting nexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH56"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="587" mass="68126" checksum="72978EB929D4BEF4" modified="2023-09-13" version="1">MFESKISFEVVAIADYEPQDERELGFKKNDKITILDDNYNWWVGYIDKTQPGLIPKNYITIELSQDEKPKDSQDSQEIDEETQLKNLPNLQEKNEKKHLKLPPKPKTKPPPLQRPNQPLKPPIPTGPKPTLNDKAKPPIPPKSRKPKPPIPTGPKPRIPVQGENKEIQSQEVKITPPKPKFVGEDLTKVMEPQKNQQIQQIQTETEPPRYFLDDKFVWNLREKITPFTFTISLSPNNKNMKSGKSEKTKFLIVSNTQTLSVEKSFIQFREFRDQLADQYKSCAIPQILPAKKITSPETFLSQFLDRISRHPILGTSSLYKEFIGLENEIKETNLAEFGFENEYETNMKSTNTTQKISIEKFSIFLQTLENQFSQLRLGFNSQSVKYKELSTVFSDLGNKVTELSRFQFDWRQKETLDKNSIDTITAIASSLVGLSSTLYKNFRLYETNPKIPNDLLSDFLNEYSVLISSFEEIWKRKIKIKAQKDLVQQTYQKLQTSSSHNFQKITTESEKLEKITNLDSKFELAILAEMEHFRYSLCQDFKIAFQRYVNSQIQIQEKVTEFWKDMLSLVKSIEVKQGSSIESKHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH97</accession>
    <name>A0A9Q0RH97_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000016">
        <property type="protein sequence ID" value="KAJ5080022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="40"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="541"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="648"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="753"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="788"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="823"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="858"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="893"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="928"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="964"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1067"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1103"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1173"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1208"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1279"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1314"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1348"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1596"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1696" mass="196365" checksum="F4E7B2D20007781E" modified="2023-09-13" version="1">MNIWKIIEQNNFQLLKQIKTIQEKDLQKNKKFLLNFAIEKKVSKEIIEFLIEKGLKPNLVDGSLRNSLHIALLNNSKLEIIEYLISKGIDINFKAKNDQTALHFACENNSLEVIKLLIEKGIDIYAKTNQNETALHFACKNNSLEIIKLLIEKGIDIYAKTKKNQTALHFACENNSLEVIKLLIEKGIDIYSKTNENQTALHFACKNNSIEVIEYLISKGIDIYAKTNQNQTALHFACENNSLEVVKLLIEKGIDINSKTNENETALHFACKNQNNSFEIVKYLISKGIFINEKMKNKVILHYICKKNQNLTVDEIEYFISKGIDINSKTNENETILHFACKNQNISYEIIKYLIEKGVDLNAKTENNETALHFACKNQNISYEIIKLLIEKGIDINSKTNQNETALHFACKQDNPSLEIIQYLIEKGVDLNAKTENNETALHFACKNKNISYEIIKYLIEKGIDINTKTFQNETILHFACKNQNISYKIIQYLIEKGDLNAKTENNETALHFACKNKNISYEIIKYLIEKGIDINTKTFQNETVLHFACKQDNPSLEIIQYLVEKGADLHIKTKYHNETLLHLVCQQTNSSLEVIKYLVSKGIYINAKINFQNETALHFACKQKNPSFEVIQVLVEKGIDINAKTIYNETPFHFICGNKNSSIDIIYYLFEKGADIHAITKRKQTALHLACENQSFEVIQFLIEKGIDVNAKIVYQNKTALHLICKQDHPPLKIIQFMVEKGIDVNTKTPYQNETALHFVCGQENPSLEVIQYFLEKGVDINAKTQKNYTFLHLICNKDNPSFETIQYLIEKGIEINAQTNSNETILHLICKQDNPSFQIIQYLVEKGIDINTKTDQNETVLHLICKQDNPSFEIIKYLIEKGIDVNTKTNQSETALHFICKKDNPSFKIIKYLIEKGVDINSKAFQSETFLQLICRKDNPSFKIIQYLVEKGIDVNAKTNYRKETALHLICQKDNSSFEIIKYLIEKGIDLQAKTKRKETALHFICKEDNSSFNGIEYLISKGIDINSKTNENYTPLHYACIHQSFETIKYLIGKGADVNAKTNRNETALHFICGKRHVSFEITKFLVEKGVDLNVKSSYENETALHLVCQSIDPPFEIIRYLIEKGSDIHPITEENENILHLICQQSTISVQIIEYIISKGIDIHAKTSQNETALHFVFWKRNAQIDIVKYLISKGIDINSKSKDQETFLHIICKQDDPSFEMIKYLVENGIDINAKTNKNETALHFISAKRNSNSFEIIKYLVEKGIDVHARTKENETVLHFVCKQDNPPIRVIKYLVENGIDINARTNKNETVLHFACQQNLSFEIIEYLVEKGVDINSKTNRNQTALHFACIHESFKAIDFLISKGIDMNIKTNENQSALNLSCYYQNQSSIKALLFHNATIFDLNKRDFSSKIVECFSQVYSINEDLSNLLKLNENFFDYQIESNDHFRFNVHKLILLSRFDSSDSYFNKFVQICSQKPKDQVEIALNFLYTGFTNFEKLSRKLKEQEKLLENYISFLYNTTKKNLDWDEEDKEKEENIIEEIFTEVFRGISTETSTNFGFVSKWIENKRGRRGILKDFEQLYHQESTKDFTIIIEENGKEREIQVHKLVLITRSELFKGMFLNVRDSSNKVHDYSGKSFETLDYFIYFLYHDSFEEETKRVYPKIIEEFEYLKDFYQLNENSTIDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHB0</accession>
    <name>A0A9Q0RHB0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000019">
        <property type="protein sequence ID" value="KAJ5079974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHB0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="17511" checksum="487CA473C253B855" modified="2023-09-13" version="1">MNNHSINQIIPSFSSSQILMGHHLTLRLSKFFFLFLEKINNLFKNFSSIQMISKIKYIEYQRKRQEKIISVFKLSKLLFRDKNGKKEKDIRFFDRISRHSKTIGNMTDFRLLFVICSAQNLKIQLTPLRTTTPKNLNATNQLLSNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHJ5</accession>
    <name>A0A9Q0RHJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein dbf4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHJ5"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="188"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="241" mass="28742" checksum="AAAFCE1B1B397EB6" modified="2023-09-13" version="1">MNNNNNNNLSLSSKYFYLSLSSTTKSQQITKKIQNFNGNITDTLSENVNFYISDDPKFIKKFNSNENKNSNKNNEIKKIIENLKSWKTRVLNFDQVDSYLDKVHNLVISSQNTKVILPFISIVDITYFFKPSYKECVEDPLPDLNTFYKKRPKQRRSDWNYSMIPKRKTTPFKPKQKNQPIKKKTKKNDSDKKFCEICNEYYLDRKKHTNSQNHKSLIPDEKEYVKVDILFQYLEEEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHS8</accession>
    <name>A0A9Q0RHS8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine rich repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000010">
        <property type="protein sequence ID" value="KAJ5080469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHS8"/>
    <dbReference type="OMA" id="PGTWTDD"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF35">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="384" mass="42326" checksum="83A2A442BF9786D0" modified="2023-09-13" version="1">MFQNESKELLKALQTGEWESLSKLTKISWEKYNQSLGCFIGAAIGDSSGSYLEMIGRKPNEDEVLRALKMPGGGVWRVGSGQLTDDTEMALSLAKGLISPLDHSKTTFNINQIAYQYGQWLKSGPFDMGYTTQKALIPILKADPDDPKLASKMINQSKKLNSESKANGSLMRATPLAIWGHQLPVKTLAECARTDSRLTHPNPSCADAVAAYVIACAHLINHPGENKEAFSIAEQWIKENACEEVQEWIGLAKENKDIPYYPLAGFVKIAFVHAFRHLLLGTSFELALKETLLGGGDTDTNAAIVCGLIGAFHGITQIPKSFVNSLLNCKFSKEVPRPQNFHPSIIPYYVRSLLEIAPESLQKVKNETNTNTNTNTNTNEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RJ48</accession>
    <name>A0A9Q0RJ48_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RJ48"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="167" mass="19102" checksum="92D173116FEDE1AC" modified="2023-09-13" version="1">MVVVSLPQFQEFKRRIRENPALLQTVLAQLSQTNPDLVQYIAQHPQEFIQLLSDDGDDGPQFGGDDQDPNQGPQRQHTIQVTQEEKEQIERLVGLGFDRTTVLQAWLACDRNEALAANLLFSWGADEQEQPEPQHHQDPIHPPDDQNDQDHDDKGDQDDDQDMDQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4R8</accession>
    <name>A0A9Q0L4R8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4R8"/>
    <dbReference type="OMA" id="CHEVRHH"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="26783" checksum="A5FFE82162AA9DEA" modified="2023-09-13" version="1">MPGYKCVFVGDKESKKTEMIITYLKGEYPEKYVPSVFENQDVYVELERKTFQLRLWDTGGQNDYDRLRPLSYPNTNVVLICFSIVNQKSFENVKNKWIPEIQHFCPKVPFILVGTELDKRDDQETINELKEKGLSPITYQQGLEMAKEFKAFNYIECSARKQQNLKEVFQEAVRASRNPKYYIQFKKKKEKEEKAKLKQKQKEEQKKKKEEQKKKKEKEKKKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7H4</accession>
    <name>A0A9Q0L7H4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_03548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7H4"/>
    <dbReference type="OMA" id="HTAHHRF"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37458">
        <property type="entry name" value="THISBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37458:SF1">
        <property type="entry name" value="THISBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="9">
        <location>
            <begin position="211"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="362"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5066215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1247" mass="148611" checksum="915F34CCFED4B35F" modified="2023-09-13" version="1">MKIKIENENENQNQNLNQNQNQNQNQNQNQNENENQNENQNENQNQNQNQNLNQNQNENQNQNQNQNQNQNQNQNQNQNENQNENQNQNQNENENQNENQNQNQNQNQNQNQNQNQNENENQNENQNQNQNQNQNQNQNQNQNENQNQNENQNQNQNQNQNQNQNQNENQNENDNQNQNQNQNENQIQKSNQIQNQIEQTLTIIKTDQKFQTSFLLTIHNFKEESHKYQKIASPIFGTNDSYYSVLVFPNGLTGNGSLSLFLRIEKIDNTLKKWQKYCTFEFAIIDKSTSKIIANKSSHHIFTKDNVEWGFRNIINEEKFEKLLIKNGGELLIKIHLSTQKDIYYEQWMISNYDSKLETGFVGIKPKKRYLFCNSLIQTLFHIGLFRKLLFEEFKIDPIKPFNQQKENGDSTRFEKFFLELQTVFSQLQTSETRISTKDLTRSLRIEGLDVKLRYEPNEFQRYVFFVLENLSNKFDFENDFLSLFRGEFIEHQISLQEKDNNQLRKKKFYEIPLEIEGCQDDQTSNQNIKRQLELLPPILTLSLNRFDYDTENEAIYKIDDYFQYHFSINLSNYVDKNKKFEKEQTNYVLYSVFVHEGSARSRKFFIYLKPRKDKSWFKFEDHIITKAKEQDILEPNFGGTKHKKNPNSLFSQMIKKLSTCAYKLIYIQESELEKIQQDVTENDISKQFQKHIQTFLTKKKSILKAKQEKEVFIPLKILTDDLIHKTKHQHRDITNFKMIKPRKIRKTTTILELKQIISKEQKIPPEKQILWTLCRRENRSIRFRKSISQEKHNSTTLDSIKELADELPIIYVEESKSPLTKINQAERRQKSILLSFRYYSPEKKQMSYVGSYRVGLKELISSIIPKLKEFQNLPEKEEIILFEEIYSKRIELIDINKTFEESELISGDIIWFQQNPSKIKEVYEFPTITHYFQFINNHIIIKLRDLSEPQKTKFWIPMLLTMTYDEVSKKIGETVGIDPEYLRLATVNHRTKKPTKEIPRNKNLILKDMILLKDGTKKSKQIFYSSSNFSFQELATKNDIPLDYYTKSMKHYQTIHILVSKNGIFEDLMNEFISKNPCKIENIEKKEFRVLQVINSKIKTIFDSKDIVPNNLGVSLRIEEIPESQKGLSFQNIFKICHFYQESSGLFFFAKPFLFELKSNFEIVKEAKERIRQILEIPEHIFKTWKFYALKKNNIYFKLHDDEFIYPFLEVGQIGIMHDYQPTKRGPISDKANRAALDPLFRKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7H8</accession>
    <name>A0A9Q0L7H8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7H8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="477"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="584" mass="68237" checksum="B7BE956BDC7FCFB1" modified="2023-09-13" version="1">MNEIIFFGSNQFPKIIKNESNKITKPIQFKFENENEKQIKQISSGNYSTIFLFKNGKAIEYLEDSDQNPEKIQIENIQKVTVGYYNEAILTKEGNVFAKGENINSKDPKEFINISSLIEDKNDRIIQDIVSGYNTIYLLTSNQNTYGIGSNRSCQLGFDSKTLEEAEKPILIMKNVSKIFSGNSSQSFFLLNSNQELFGCGYNFYAQLGLGESRKEETIQKLTQIQNIPKGKIIDIKCGLAHSIMLIEDENENQNPKRKLYSCGYHVYNGLRYDKFIRDFTEIKSYLFENDDNILDFSVGCFHTLILTSKGKFIAFGSNSYGELGIKITEIERVPIQIELPKLRFNENISNYHVSCGYQKSFLYYSPSSFSNLEEDLIKLFKRKEFCDISFKTENGEIISAHKLILKYRLNQIENQIEKLQEIISTKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITEEIIDEIQIGIDYFQLNQTNPNLFDLLIKKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L877</accession>
    <name>A0A9Q0L877_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant sh3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L877"/>
    <dbReference type="OrthoDB" id="10688405at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17671">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="5">
        <location>
            <begin position="603"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="5">
        <location>
            <begin position="873"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="779"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1015" mass="119810" checksum="CA2237D8275A5AB0" modified="2023-09-13" version="1">MTEKIVLKENYIEKLSGKRNKFQKRFFLLQNMFLSYRREQKDQEVLGTIFLPHFHIKSSSPKQERNYVIELKPINSKYSERSYILATGTESEKNEWINALQKGKDLFKEKLTTLTKEVDFKDSLQKRQHKITTQWKDQYCVIERNIFHIFNDEKCNPLIDSISLRNADIFPAPHKEHSNKKYSGSCFVINVSRKFKKTTLTKTEDPFFFGFSNRNITEEDSHVSKNNSKSESPMKFHRSTQLLFSSKRKLDTNTLQVIQKESNQNSKEDTFEFAFSTKDVDDIFHNESLDDIDFGENENSPRMTSKSLSNKANKNKSLEEMGKSQTLDSTYNNLQKNDNQNAKSKNEQIERQVAWANKQKEKKYQEKKHQIREIIKDISQHSKNTYTKFDKFIKDFTFPFKEYSEDIIGSFNEEEYLKKETEILDELDLFVLQSQAQSHLQEKPQMTESKESKESKELKTKESKESKESKTKESKEIKTKELKTKESKELKTKESKESKTKESKESKESKELKESKESKESKTKESKTKESKTKESKTKESKTKESKTKESKTKESKTKESKTKESTNLSQLEKNILLEFEKANNNLQSKYPIQAKAKNRKVKTSDPDAFMIIRILSFLFSQGLSDQFNSFFQAIENLKHPIMSQAFFFIRQRNAEYIAPNNPNLFKSAVFFLYSLNKSKLSSYFEVLISEDFISQNYQKNAIIRNQEFMNQLKNIILKLETIYFALPIDVSELLLPYIQNPSNEVNKPKEKHEKHEKHEKHEKHENHEKHEKHENHENQQNQNQKNQNQKNQENLQNQQNQQKHENQQNQQNQQNLQNQENLPNSQKLIEPTQTLSPNLEVLSKTVQEILTQFGNTEKDKIQEFGDESKNPSISKLIRLELCDNITRIFLQGFKKSKFARRSKNHIWNYFENPGHFINQSLDPDISDIYNIIQEINSDPKFSKKKQYDLDQKVQRFLCKGLNLRKLDEWMKILTLETTASKQYEEKALIRDVQSRDYFISILEPLKKIPFSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8B5</accession>
    <name>A0A9Q0L8B5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8B5"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="70" mass="8463" checksum="60EE0A29F4A71688" modified="2023-09-13" version="1">MRSELYRGMFLSVTEDNSNKVTDYSELSNKSFQIFEYWIYLNQIKNEIQITQEIINEIKIGIDYFQLNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Q1</accession>
    <name>A0A9Q0L8Q1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8Q1"/>
    <dbReference type="OMA" id="EECIICY"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="405"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="565" mass="68492" checksum="0221ABCED7E4E0B1" modified="2023-09-13" version="1">MNFGLYKNQKEILFCSICKNPIKIFALGKCNHRQTCWRCLIRMDKKKEKRTCPVCKKETQDIIMTHSNLKQFEEFDLKTMYYEKKLNFFYQQTGVLFEILEAYRLICPICKMIHNTEEDLKLHLNVEHEMFLCDVCLEYGNFLQDELQIYSRKELLIHQGNHPFCKCCNISFFDTEKFAVHCVQNHYICEICKKNDIDDVYYCSYKELEAHFNHQHYLCNNVDCLNARFVVFETKNQLMKHIEKFHKENNNLANPKLDLQKNHKENHHNSNYKSNYYDRRNQNFIRYGNDFQNNFQIENLFLQKTYVDQFESEKAFLRQKQNEKLLFEIEHNYGNDKLKEFNENFYKFVFGKVNTAYFYNSLSTLFNSDFLEKIINDIIEIIPNQKLQQDLVNFIDRKEIKNQNKNKNQNNQNNQNQNQNQNQNQNQNQNQNNQNQNNRNQQNQNNQKNQNNQNQNQNQNQNQNQNQYQNQYQKKWKPKIIPSKNQNNQNQNNQNNQNNQNNQNNQNQNTKKYQKKIKEKNNLFTQEDFPDLLQSLEEPKQITKKGTQNSKRKNSRRKKKVQKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8T4</accession>
    <name>A0A9Q0L8T4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8T4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="316"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68583" checksum="68FBBD1F5D2F51DA" modified="2023-09-13" version="1">MNSNQFNQVFFFGSNVFFSFFKNKPTKITQLNEFQLKNQKNQIKKIYPSQPLIFLFENGKAIEYLTEENDLNQNIEKIQIEENIQKVAFGYRKQAILTIEGNVFVKGMNINPENPKEFINISSLIKNKKDRIIQDIASGYGTIYLLTSNQNAYGIGSNTSGQLGAKALNKTKKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGCGNNLYSQLGLGESRKERKIQKLTKIQNIPKGKIIDIQCGDYHSIMLIENENENQNPKRKLYSCGYYEFVGIENDQKSNEFTEIKSSLFENDDNILEISVGNSHTLILTGNGKLIGFGNNDDGQLGTGDTERQLIPIQIELPELLFDISYYHISCGNYNSFLYYSPPSFSNLEEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLNQNENEFEKLQEIISKKSIKESNQIFEMIYLNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNQIKDEIQITQKIINELKTGIDYFQLNQTNPNLFDLLFNKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8V9</accession>
    <name>A0A9Q0L8V9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beach domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8V9"/>
    <dbReference type="OMA" id="PEWCHEN"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="507" mass="59869" checksum="113AEC1DEDEADFAA" modified="2023-09-13" version="1">MINEIKNKNKNKNKNNKFIGELIPEFYHLPDFLRKPEIFKNENQKTILKKIKNVKLPNWANTAEKFIQIQKEALESEYVSKYLNKWIDLIFGYKQVKQKEQTPIQLFTKKHPKRFSKTEIEKKQKITNFFPIFFEWENISKYKYFQLTKYEISSNPIILINFQEIPKENKSKFSYKIITMDKEGIIGKYSGDILEKSNEKNRFFQLIRDKKSQKQKGIQNSKQEIIIPNLNINQNKKKNKKKMKNQIEIIFPQDFNNYQECLLIDKDSKYLFCCGFNDNSFKIINVQNYEIIKSISKHQDIVNCLSNDWKYIVTGSKDTTVIVWEIELKENKVKEIAKHIFFEHKKEVKSVAISIEYDIVLSGSIDGKLIFHSLNKGKHIQTITSEDEKPITKIKITKEGDIITFSENSNILRLFTINGFLLRRIQCSENIYSISISEDSKFIITGGEKGKLEIRKIFNLKTIQEFDLNETIYSISIIQKVFLIIGLKNGFIKIGYFTDQNLNQNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9I1</accession>
    <name>A0A9Q0L9I1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9I1"/>
    <dbReference type="OMA" id="FCEDIIT"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="3">
        <location>
            <begin position="206"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="332"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="471" mass="57679" checksum="46856FDA5479E6E9" modified="2023-09-13" version="1">MIKKSIMKKYPWNSNIIPILDYKLEKEQFYLKLSEKEDEIRRQKKLKFYSTNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQKEKNKLIKLKQKIQKEIIEISNKLSKNKNKNKNKNQNQNENENQNENENENENENQNQNQNQNQNKNKNENQNENQNQNENENQNQNQNKNKNQNQNKNKNENENENKNKNQNENKNENKNENEIITKKCEIISKNKIIKGKIEIIKNSINFFVKFDLKKEDDEDDEDDENEEKEIKNYLWKIEMIKTIQKRKYFYQNTSIEIFFENNRKYIFFNFKTEKERDEIYEKIQKYKLLNNNSNNNIIQYNYSTNEMNNITKQWQERKINNFEYLMYLNTISGRTYQDLSQYPIFPWIISDYESYLIDINNPKIFRDLSKPITKLNQNQNQNQNQNQNQNQNQKIHNHKFKFKIKIKIKIKIKFNLKMIMKISIIINIIQILKLFHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAC9</accession>
    <name>A0A9Q0LAC9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAC9"/>
    <dbReference type="OMA" id="LQLQFMR"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF96">
        <property type="entry name" value="BCDNA.GH08385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25880">
        <property type="entry name" value="WHD_CHMP7_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="57138" checksum="DE1109C1C48A8A03" modified="2023-09-13" version="1">MEEFLKNFPEWEDDSRINVLFSELPNAEIAPDAYQNRIKFWENIIESCSSHFNWSIITESIIRKKFTRKGMIPVCLPAIFQYLEKQNKICKIDSFLKNQKGFSLDLIKSVFPNNNPNKSNSNDSQGVFSWIYDNVLKKPVVYLGSFVYDFESNEKNEKSVKNDNSNQEYLVFQQIEKKSNELLKIIHAKFTGSLVSRVLTVDKILKLGKNIFQQNQDLNSKSNSNSKSNINLIDEETKKIIYLSLYYLVTQEKCFVIPNQKDQTKIEGVIFSSPNSLKEKIQSFSQVEQTIATIKNAICKLKTQLKSLEAEIEHKKQLALAQKKKNNIKLALYQMKLAKNLESTLSKRNQSIDTLKEILFKIEKTESDKEIVEAMKSGTQAFKALTTDAGFTAETVEDVIDDLQDAMDEQKQIEDALSTGISTTNLIDGDEDDDELSKELEQLTLQSSQNLENSNELEIPDEKPKEIINKLNFPSLDQIEEKTKEEQKEEQKQILTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAL0</accession>
    <name>A0A9Q0LAL0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Grip and coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAL0"/>
    <dbReference type="OMA" id="LKFKCSE"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101283">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="3">
        <location>
            <begin position="581"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="444"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="638" mass="76507" checksum="C94C096C1C219C0E" modified="2023-09-13" version="1">MSNENKNQNLNQNQNQNLNQNQNLNENKNQNENENQNQNQNENQNENQNENQNLNENQNENLNENENENENQNQNQNQNQNQNQNQNQNQNQIQNQNQNQNQNQNENENQNLNQNLNENHNENLNENQNQNQNQNQIQIQNQNQNQIQNQNNSLELQEKLKELQQNYLNIQKENQKLKENSPTHKLELKIKNLENYLQQIEQEKTRIETEKTSQQNKIMEFEEKIGQIGIQLAQKNQEVDDLEKKLNHFKILLKKANDHIQELKKKNESKNSESNSLNQNYQELKKKNEDLEAKLETFTKSKTEEKEEIIKYQDELNQQKELVNQLQFKTQNFEEEIKKKDLMIQNLESINKKQEEDFTAYKSRAQIALAQKMEENSQANKPNPEMEYFKQEIQELNQKIKKIQTLNEKLQKKLQKKQIQFESNIPQISSTENKEYEKKIKQIETQWSQKYDQLSQERENLTKLHLKKNQEMNFKHKKILDEMTKQIQELQQEKFSISQNHENQKSQNEMTIQNLNNEIQSLKKQNQELLSESQLKFSKQIFQNQNENQNEKNKTILIQKPKESPNQTLINSGNQSKTKEIKFDPTQFNYLKNIIMQYMMDNEQHEKLIPVIAALLKLTKKDLQKIEDARSKKGWGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBL9</accession>
    <name>A0A9Q0LBL9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coactosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBL9"/>
    <dbReference type="OMA" id="WIGPNCK"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="143" mass="16228" checksum="A8B0B0B7362780DE" modified="2023-09-13" version="1">MCDTSDPAIKQAYDDVRDDSNETTWAVFSYEADSNKLQVIGTGTQSVDEFLPLLADDIVAYVYFRVISGDEESKRPKFVFTTWIGDNVKIMRKAKVSVHKADVKKIVRQFAVEMQAFDHDDLAIEQVMKEVRKAGGADYHGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBT1</accession>
    <name>A0A9Q0LBT1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Receptor expression-enhancing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBT1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="50379" checksum="4EABD5B30EA8298D" modified="2023-09-13" version="1">MISHLFFFIFGFLIPFFYTINGKEKNPKKEFFERTLIFWIFFSLYLIFIRILDQTISSFIPFYEFILIIGNLFLLFLLTKFGAAKYLRNFLMNFLQTIDWIFFFFQMAKKSINFTKNLFSFFSSIFGSPKKMKKKSTSSQTSHKKKFIKTKIEENANQISSNTTVNNLKENDEENDETQNVNTSYQQNSNNGMDLYQENIHENNTNEIQDENVEIKNIISSLEEEKIEMKEKIPKIEAKSNIKKHEENLSESKEKILENQVKSVNPNNSTINIGEFYSPKTNSQRIIFPTDEKNGNNFPEYIVDKENIDSNLQEEKTPNKTNLIVSDEYHSPDDFESDEDSDPKSESLNQPYISPMDIEDSKSAEKIIEEEKKKKISNTTSKKRVHEKKKKKKKKRKSEKENQRKKKPKINEKKKKKKMKRNGKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBU3</accession>
    <name>A0A9Q0LBU3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBU3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="423" mass="50859" checksum="975979E28165B60F" modified="2023-09-13" version="1">MSHRRRNQISKRVHENARTTTQRPINLKINKNQKIKNNETKKESNKKKRKSNEKSNEKSNKKSNKKSNKKETINEEVNQNLMDLEKEKRKEKRKTTKRPINLTFHHKKKDLNTDPSELMLNQQLKIQDEKDFQIDIENQNENLNLNQNENLNLNLNQNENLNLNQNENLNDFNLYSDDNFIIENDNQSDSDYQIENDNIFKDSNQFINESKEIQIEKRRRTTKRKIQVFHREPIQENQYEDELLQTSSQDEPPDTINSEMKISREEEKKFPILTAIISQKFPKRKIKRQINEVDVIMKFIDDCKEEIMSQIEDKEDNEDLIDLYKIQVDLFLSHIFSEFAIYRKVRTNQWKYQQLTNKIQKESGLIRNSIVELREKIQKIDENLNNMKEKSNKIEETISTKQKTTNYLQQFEKLLQKAKEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDZ6</accession>
    <name>A0A9Q0LDZ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kismet isoform c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="TAYLHIE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1802"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1893"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2156"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1803"/>
            <end position="1836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2274" mass="268271" checksum="0379AF862F715C00" modified="2023-09-13" version="1">MNQSYSLKCSALQTKLIKFLETCSIKDFETTLSSIKKWPFSEITEYKNWEKILTRIHNILSSELLTDSFTKNLEKANSSKNKNLVLSIIKFLHIFLKSLKIRTPLEKWGEIISKIMFTQCEYILPSLLVLNKAHILQNSQNEPFFEKILFGLISLTQITPLFSKDTLSSNKIFESHQINQNIQKKEISITIAISVSKSLSQKDQHDLHVFIPSQEIPKQKKNQQIIDEISIDINNCAKNPNIFAYDILSKIKEKIDDKQQIQLFIQLLKIHSSISGEEWLRSLFKTQIHSFFLFLKTRFGAQFILSNQPSEHLQKLEILSDIIMHNKYVDQETKIFSIYLMIQLIKMLVKLLNSKPNNEGIKRAIYHSIFQLFSFYKSQIEAISSQNPKSKELIFLGYLFIALFQFDSLVSQFKLHSSIISIPECNKFFRYYIDEHSEEYLDLFLQFFHLFKMYVLKSKDRVRYFNLEKNIISSIFQRIEFEIDFLSSQNQTDISLSIKKSLSNIHEIEFTKDYFNSITIISQRKNVLSNLLFFGSFISLSRKNRNFFQFITETKIFVILSKIFQNQQLCRDSSLIFMHSSLILFVVIEFLPFTNADALLESKIPFYWISILKSSMPFNSRVIQNIPNTLFHLCKIQEGKKLVVETKIFETFLSLFFNPNYYFITSNFKEHFLIKFSQIIFKLEIPNLLQSISTSLVKYIKKLYDGYCEKHIHGIGNKDDNHPCFVSIFDNISHVLNKIFRFDSLVTVFFEKGVFAEILKVFSYDNLWKPTCIDNEDKKLVDSIIYTIIDIPEHHITPFYKLLFTQFLSILKSTKSPASLHIQAIYRCIFFIYKFQKKLLKEKKNHTFVVNSWGGSLTQEINDILGSILYVCTYKIIRKDLLSESDNFSDYVQLRLIVTKLLSQLCLFAFLSSRAHKNLSISIAKYSNVPMARIGSSISQIVENQFDKFFQKNQFSPAIQPYDFLIFSSLIKQLNSLMIVSSKEKEITFSPINVLLLAFFVESQTFNKIFDYFSFILSQIPVYFPKDRAEIKYSNEFHNVLQSTLQFFRIITNFHHFADSQIFPFIENRELNGIQGESFVFRFYSFFQKVTTKCYDKFLCVLIKQNDIYINFPKQLIATFIEIINNLLRATSKSFFEKINSQKQQQQQKQQEQSEKGVLHNSPNSSRFQPKKLFLNNLIEMGFERSISEIALIKFRNNITKATEWLLRSPSIANNIPQQTIFQENNDPPKNDQDSKKEDPSPSNQQQADFHLEEISIDINKSYPDILMEIAENTTENHELAVRSLSFYVAFVSEDHPAYSILIGSKITSKILFFINNTEEYFSPKFARILKFLSFLFHFDITPNIEFQKPLPLSMANLWHNFLNGIIIFFKRESMHIHLLNYLSKVSNHKKPESYHLFNKCVGYCFLILLRLENFNQQNPKEKNNLSIISTKKIVEILIQFLKNHHHHHSNRFFIQISLYCLSILTLHQEIAKYFFENDGLQLILVILSPQKENNKNNFETARSALILGNLLEDTKTVAQLMVNSLKTTFKSQNQISLEKFPGTFCSLSNRNFSLFISLITKFCRVSSSHQSLVILKSQSIPEICDLKNHSVLNLITQILLDLIQSHVQSQENSSEKISQIDNLLSILLYIFSAYEIPSCLDKYNLESIINSYLEMITKLLFQKEDKTDFQHANSFFTLITFVSYILTWNKNLQITSFILQLYNIVIYFFKHSLQSYHEINEILQFFYYLIPENSSNSKIQSFLNSNIGKFILFDPKHNLFDFIFQVFSLINFKQNNKSVRILLKLYTNLLKITFSTPFQKKNQNQNQNQNQNQNQNQNQNQNQNQNENQNENENQNQNQYQNQNQNQNQNQIENDYEIENEIEIEGNTIQESFNFDLDPNFGIDTNITEDEYENLQDQDQDEDEDEDDDDDENENENENENEIQIEYENENENENEYEDEYEDEDEEENEIENIIENEYHDEDESYYENENENGNEIEIEIEEDDEDEDEDEDLHNNLNMNFFNLNPRNHVPNLQNFRIQDPVSNQLNRGLFIFDALDNSYPNEFLSLGDLLSNERRSRRRRRDIFFRDENQHRRNDDRDNFRHNFIINNEESLSSDFIFPSIKDYLRLIIMSINEERGFGIIFKDDENINENINEKINENINQNINQNINQNINQNINQNINENINQMKNINENINQNINQNINQNINENINENINENINENINENINENINENINENINENINENINENINENINENINENINENINENINENINENINRKYKSKYKSKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEM5</accession>
    <name>A0A9Q0LEM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein fmp42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_10280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEM5"/>
    <dbReference type="OMA" id="CNILQQV"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040129789" evidence="8">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="438" mass="50089" checksum="3C080FA5B86C77A3" modified="2023-09-13" version="1">MNKIILFITIILLSSTVAGVYFGWPSFAIILKKENFATENCDFTNTNKCDSQNYKIHQIFIIPSILNIVFSTVIGILIDRFGNQRSILVLSILFSIGSLFIAFSQNFAGFIIGFTLIYSNGLGMLSVVSRFCQYFSPKTQRILLCLVNGLFDSSLIMMVFFLFLYEKHFSIRTIFSSYAVYSLFVGLVSFFSSKVEKKQSEKESTPTSDLDSDVELNTPYKQMSQSEILSQKFGNLDFKHQFRSSYFWVLFAFMGSLSFFANFYLATLEQRIEFYSKSSTTTNHYVKLFSFLQLTGFLYSPFIGILGNNHLISAILSTVSAVVLIGILNTTSEVSLQIIGFLIFPLSRALIYGVNALMLKAMFGYQNLGKHLGIQISLAGIAFLLQYLISYILNQKLHGDFQYIDWFLFLITFSSIFCGIYFYQEIFKFRQNWITIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFS9</accession>
    <name>A0A9Q0LFS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor protein isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFS9"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="587" mass="68763" checksum="72D9084FDA2E8F0A" modified="2023-09-13" version="1">MSQNNDQTNMIPKEFTYHSKLKVCLEWIQQEMEDAKITEEDIMDPNSILLCELINKLSPNEKPIPKINRTRSFVAQKSNIRAFRRALGEFEIDDFDWNQLDSFLSKKPKARDQVLNALLKLRDKFLFGFDKSTTDQAFNSDSSVQNENLPSPNNSNSNLIDEKAKPKLLRSSKTQAQIPTRQHTEIIPKTKSFFESKRSHSIKMKNESKNESKNQSKNQSKNQSKNQSKNQSKNESKNQSKTNRQRRPKRILSMPKIMHKKKQQFIRIVEESENPIEIEELFQLDLIYISISHNQWNQFSSKQIQEEQNIEQNPKSEEIPQEISIENKVTNHIRKGKVNFQVNLINESKNNKIQNEQAVISVNKTSISITNSEGSRLFRIKWNPKLKVLTKDQNSSLFSIEFTSESKTVFDFNANNPFQREEIAQTITRFNNARMKNFKTEKFEQTEFQRENLPKKLSRRIFSQKKLTEQNILQNPDVYCPHFEKNGGVTFIIAVWLGDNFITGYLKIEPKRFKLGIKQDNKYSRLINQNYSSNFEISRIRKSDKILLIIPDISKNEKAVIQCETSQIAEIIFESFHFFSSKVKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFW1</accession>
    <name>A0A9Q0LFW1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Osmc family peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFW1"/>
    <dbReference type="OMA" id="CKLEVEW"/>
    <dbReference type="OrthoDB" id="3906254at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="174" mass="19467" checksum="5FD0805DC037E178" modified="2023-09-13" version="1">MLSAISVKPKKSFSSLFLRSASKLFPIKVSGVSQQKEPLHIKIQAEKYQFDIDEPKKIGGTETGPSPLHVMLSSLAGCEVVLFRLVARQKKVQIGEVQIEVNGELDPTSFRNPDIFPGFQKIEVEMKLESEADDKTIHEVFELAEKKCPIASIVGTHPKITFTSKWERLSKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGZ8</accession>
    <name>A0A9Q0LGZ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cnh domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGZ8"/>
    <dbReference type="OMA" id="MFVTSEG"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="16"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="917" mass="106404" checksum="3D141F6F614BCD15" modified="2023-09-13" version="1">MLQAFDLIPTNIDQQSKTLNTFANWKNEKIIIGTTDGNLILYQNTQKDDEIKPSFRFITQVKIGKKPVEKLVILNQDHLFVLCDSKLKHYSTNSLDEIDVIQKNGVKNFCVDLKKRDRRFCICLSKRMKLFNFRNGEYKVFKELLMPEPPIAIEWYGNSIFVGYQRGYRLISVSAGDVKEMFALSRAKPHIIFLSDSKEFLLVDDKVGVVVTLRGEPSRGSVAWSDTPIRADYLTPFVIGILPKEITIHSWYDQRLLQSLSLLQVQSITISDPFAFIATRTEIFALLKIPIETQVDQLIEKHQYTKALELYEKSAPKDNQTSLQDHKKKLLLIHLKVGYMLVKDLLFDEAFEHFYKGNLDPRELISLFPQHLLKKSEYKPTNPFTGHDVPVFIESIILSNIPHEKDLKAVNRFEPTLKRYLEQFTTKTVIFIEKEREKYQKIYEENKVDENIIQINQDENNNNDFDDDNDNNNNNQNNKEKEERENQIKLKNQLKSEAKSILIEIDTALTKFYSTLDPMKFSQFVESENFCDLTDLKDFFLDRKMYSELANVYKGKKNYRTALEIWANLGSQKFKQEGQNGINETVSCLIELSDPNLIWAFSRWVLEKSPNIGIKIFTSEKRETPLKANDVLDYLAQFKDDEMKFRYLEFTIFTEKNTDKKLHNQLAMHFVEILLAIVPRDDGKQPKGKNRPVPGTEYGVLGSTRKKLILLLQTSNYYDPEILFEKIKGSSLFEEETILLEKMGRYRDGLNILIHKMGNRGDAEKYCEDPNPKNHQEKLLELVCLSLYPPDNSAPLIDDAIAIINKHSCELNPANVLKKLPDDLPLSEISSFLSISIRELAHQKRHSQIFKNLKKNESLLSDWKLKNLEKQKLKIIPKTKCDKCKEKLGASVVARFPTGHVVHYGCLKDFNPQKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH29</accession>
    <name>A0A9Q0LH29_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase fhke-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH29"/>
    <dbReference type="OMA" id="HNPENIM"/>
    <dbReference type="OrthoDB" id="336747at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="166" mass="19028" checksum="2C235B5F83722D33" modified="2023-09-13" version="1">MHNPENIMLVNSKDDTSIKICDFGLSRFTSEKEKMSTFVGTLQYLAPEIIVQLYPESIAKGYTKACDLWSCGIILYVLLSGYIPFTSLKQTMIMKQILEGDIDFPPDIFSNVSIAARNLIRRMLTVDPLHRITAEEALQHPWILGQSEKIKDEMQDVWTKKPKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH40</accession>
    <name>A0A9Q0LH40_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crossover suppressor on 3 of gowen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH40"/>
    <dbReference type="OMA" id="PYLVIFE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="520"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="808"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="965"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1167" mass="142634" checksum="A6686F44397CA167" modified="2023-09-13" version="1">MEENYLKFYSNFNKENQFKNQNQNENQFKNQFENQNQIQNENQFEYEFKNENQFENQFKNKNQFKNQFENEFKNQNQFENENQFKNQFKNQNENQFGNEFKNQIQNKNQFKNEFKNENQIQNQNQFENQFKNQNQFKNQFKNQFGNQFENEFKNQFKNQFENQNQIQNENQFENQFGNGIFSLENAHNILNQSISERENTILQKEKNIIEREQKIVQTERKLEQITKQLTKQSILLNKKEYEINNKLEQTKKDFFNYQNLQEDILKRERKIKEQENQISFQKQQIQKENKEINKKLIELEEINNEIQKKENQISERQSEMNQILQDNHSKEKLLSEKENQIFNDLNEIKTINLDVEEKRKEILESENKINQKKSKWKQKAWQIHQKEQNLEQKTKQFDLMYQKIQKQSLQIENKRQQIDSEMENFQQQKIQVEKDRQYFSSQSSILENQKQVLEEQKNEIQKKKEEIINYEKQKQQELMRKEQEISQKEQIICKKFEEMTQKQRELESKEKQSQIQVSKLQEFKTNLQKRNEFIQQLEKDSKEKLFISEQHLKTIEQIKQENEGILKQIQEEKQNLETIRNDIQKKRINMKEEQTQFLNSKDSFQENMEILEKRKQENKLWEEKLEQKQKDLENRENVMENHHKTNLQMEKQLKELQKELSNKENQIHRYADEFSKQIQYKTQTQTQTIEYEKLQVMNLKEENEKKQQILEQEKANIAKEKKEYKQKREELFAKELKLNQMISQYQSEQQNLMKSKIQNEQFLNKLKEKHLKLEKRIQSLTDFENHLSTMEKDLETYLIKVRKQSIENEAQKNQYSNLLGELNEKKEEMNQKEQSLQNQQKRFNEMKRNMIEEQAKIEFKIKNLQNDLKSRRKEMEDLNLLAANRAEQFSNMMKRLKEAQIASKKPLQNGLNLYPNSEAPNEISLNQQNSYQFNVSPNNCKEPFENQKHKIKNVLKKVESQKNYLNSISQEINQYDVDLDREKKQLDFLKQNIDNDHNLDSNLKLQNQERKIFSPNLIQKKNLRNSNNNFNLNHTHNLNMDFDLNSKWNNFLSQKQNFQKDKQLIQEEWNQFNQEFGAIEKMKKALENQNGKKIFNRKEENNEKNQIDQIFEDQFNFINSLRNSINPNQNPNQNELKNELKNELKNELKNENKNMNYSFDSQNFFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHW9</accession>
    <name>A0A9Q0LHW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tobamovirus multiplication protein 1-like isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHW9"/>
    <dbReference type="OMA" id="SCTSYQH"/>
    <dbReference type="OrthoDB" id="19353at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="7">
        <location>
            <begin position="8"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="280" mass="32605" checksum="7ADD6F09DF69253D" modified="2023-09-13" version="1">MSSSNLTIFLVPICLYSLLLIMVIIQMVRLFKNKAEQNLYLVQFRTHSLLIVFLLARLLTLTLEFQNSTSLVWLFVIKRIAYLVFFTSFTLLLYFWVKISHSFQRNRRNRQTAKIPFIIINVVLYGFSLICVMIFGLSLETVSYNNSFYKANVLIIAAAFFLQSIGFVAYGIILFRKFKKMSGLFPDRKTFLAKITFVSLLISLCFLVRFVVLLYYPITARFLNSWLFLISAYLIPEIIPTLVQLIVLRPRIITEMGESETHLISDEKEQSTLYVTENTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI39</accession>
    <name>A0A9Q0LI39_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI39"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="769"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="876"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1005" mass="116509" checksum="EF178CACB571C4AF" modified="2023-09-13" version="1">MDPRFDLFQIWQKNKDDFSNFFEELTDLNSLLEELSDAEFTKICKQGFWQKFVQTLKELTKIKGYASYYWINSLSGIFMTMFAHENESTVELANYFQESDGPKLFIQSINTKGNKEEFMDILNVFGYLSEIGTTQNSIVKLGILDKIVEIFSNEKNEDFRLNYTISLILCSLSVNYKVIPQIVANKKLIDILISKLQHLLFQEIQVFIIEFLSNLVSDPDSQDYIIDHLPIPLCLANYQFPSPTSQKHQFNLIHQFILHKPQEIINLDCVKRLSEMANDFDIPEETFFAVAIELFKNPHFGSIEKNKITQDFIKQTIRLIHLLSVDRHQFQRSISSWALTELSLVPNVVFSNSQIFDPKNLTVIKKINSCFPESNFLLQLSRLSSQKINPEKCTLYGEQALQFFSVNQVMDFIYSIDEKEKTEILEKDQILQILTEKNVKKEEQKNQSKEFLWKRIKKGSIFVGICKQENFQPYPMILALDNCEELNFDGVLFWPSLNYSRVLCYGSFNPDKNEVVIVEYQMIQGAYIVVPNIYQGEIGIGDGNTISIKGYYHSSQESDIFELVLQNDTTNNNSNISSLQSSQPDLIEKEIIEKPSPLKFQQDWAENLSSTTLKKLPFMKDPQHIIKPKLHQTYFESKSSSKFRKSSSFIFDCPFTQSLSSATIITNLLSSNPAFLTQEALLLFLKRIILRMKNNVSHLQIGLIKNIYHLSLIDPKTEYSRLCKEILFFISSSSLFPSHVRKYAEKRTRKLQSTPYFRLSLSLDSQKFSDFIISSVDGSLIYTHRFILASYSPFFKHYFQDNPNATKLEFPTTKDILNLLFHTLYSRVPKKFPLEAKETIQELISKFLLPLEIIPPNILRFSSEAEKMEINSALYPTYTLIVDGTTIPTHESILYFGSDYFQGMMTFHDLSGQSSPKLEIKAQSLEMIQFVLHFLYGHDPLTSLSLEKALELLAVSNEIMLDLLRIRLESYLCDFVDFENVNDIFSFSQYHQAHFLAAFCRNFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJD6</accession>
    <name>A0A9Q0LJD6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase herc6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJD6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="169"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="285"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="458"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68951" checksum="6E3E000431E5D86F" modified="2023-09-13" version="1">MKIKKNEKQIKQIATGYFGIIFLFENGKAIEYLNENYLKQNPEKIQIEENIQKVTVGWGNETILTKEGNVFAKGKDINPKNPKEFINISSLIEDKNDRIIKDIVSGVSSIYLLTSNQNAYGIGSNEYGQLGFDFKTLKKAEKPILMMKNVSKIFSGNTSYHVFLLNSNQELFGCGWNEQRQLGLGESRREQKIPKLTQIQNIPKGKIIDIQCGCEHSIMLIEEDDEKENPKRKFYSCGIYFFNGLEKNGDTYEFTEIKSSLFENDDNILDFSVGCFHNLILTSKGKLIGFGRNYYGELGNGDIKDHRIPIQIELPKLRFNEEISNYHISCGYNKSFLYYSPFLSSFSNLEEDLIKLFKRKEFCNISFKTENGEIISAHKLILKYRLNQKNQNQIEKLQEIISKKSIKESNQIFEMIYSNKIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVKDYSELSNKSFQIFEYWIYSNQIKDEIKITQEIIGEIKIGIDYFQLNQTNPNLLDLLINKFNIQNPKQNTNQIQIQIQNQNQKKKDKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK73</accession>
    <name>A0A9Q0LK73_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK73"/>
    <dbReference type="OMA" id="DIKPRDS"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="694" mass="77331" checksum="FCA08D3E6388E721" modified="2023-09-13" version="1">MIANKTDSKSITISISNTNSNSTSNNSNNSNNSNNLNNFNNLNNLNNFNNSNNLNNSNNLNNSNNLNNLNNLNNLNNLNNLNNLNNLNNSNNLNNLNNLNNSNNSNNSNNLNNLNNSNNFNNLNNNFNKLNNLNNLNNLNNSNNSNNSNNLNNLNNSNNLNNLNNSNNSNNLNNSNNLNNLNNLNNLNNLNNSNNLNNLNNLNNSNKLNNSNNLNNLNNSNNLNNSNNLNNSNNSNNSNNLNNLNNLNNLNNSRNLNSRHLIIPDIKNLSSPRSPNLKTINQNSNQNSNQNQILNSNSNKNPNSNPNSNLNPNSNSNSNSNSNSNSNSNPNSNSRQRSSSPNSRQRSSSPNSKQRIPNLNSNSNSSSNPNSNSNSNSNSNSNPNPNSNSNSNSNLNSNSNPNSNSNSNSNSNSNPNPNPNPNSNSNSNSNSNPNPNLNLNSNSRQRSSSPNSRQRSSNSNSRQRSSSPNSRHRSSNSNSRQRSSNSNPNFKFKSKFKSKFKFKFKSKFKSKFKSKFKSKSNPNLNLNQNQNQNNLQTLNESDMEDSNGIVYSPNSRTSSKMTPFFSQFSGNSSQINNSINVQNSKTNSFPNSRLKNSRDEKQSLLFRNLDQKNTQNEQISNISPNSNSRSNSRSNSRSNSRSNSRSNSNSNSKSNSNSNSNSRIKFKIKFKFKFKFKFKFKFKFKFKTSSFSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKQ8</accession>
    <name>A0A9Q0LKQ8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_07629</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKQ8"/>
    <dbReference type="OMA" id="NTRACMP"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030908">
        <property type="term" value="P:protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="288"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="645"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="855"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1005"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="879"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5075276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1136" mass="130063" checksum="2F7E1DE2AED767ED" modified="2023-09-13" version="1">MEIEERNQVYKRQFIEFLRIENNDKRIDQMIDQKMQRTIINANDLRNFDPKLCSEFINHPADYLQAFNDALTEIVNDKFPNYANTFDYENFFIGIEGNLGEIHHTSPRQLKSSLLGKLVCINGIVNKCSIVRPKVVQSVHYCKVTTKTMARVYRDETSIDGLPTGFMYPTTDDEGNALVTEYGLSKYKDYQRLTIQETPETLPTGQLPRSIEIILENDLVDSVKPGDRAKIYGIFRALAGKATGLVSDVFPTVVLANNVSKDDKGTLPKQLTDQDVSSIREFSKRKDLFEVLTNSIAPSIYGHEMLKKSLLLMLLGGVERVLANKAHLRGDINILMIGDPSTAKCFLKNTPIVRFDGTICSVQDVSAGDVLMGDDLQKRVVQVTTSGHSMMYRVVPKLGDSFIVNGDHLLSIKVEKSGTKNNGLNGDFYSKNSFFQTEISVDSFLRLPRYLQQKCRLFRKSVEYPEKIVDFDPFLIGFWIGNCSLDSFVSFKDFCSKFVGKSVGCLSEEKLLDLDLEMEEKRHIPEKYLINNSKIRERLLLGLFSSRIGSIQEEDSIGLFSFVIPNLERNQKLVSDILYLSRSLGFCCEKVDFKERIEVIVYGSKQEESKKMIEKGEFINLAKANEDFLMTSFEVEKYGYDDYYGFSVDGNHRFLLGDFTVAHNSQLCRFILNIAPLAISTTGRGSTGVGLTAAVTTDPETREKRLEAGAMVLADRGIVIIDEFDKMSFLDRIAIHEAMEQQTVTISKAGIHTSLNARCSVIAAANPIYGQYDRTKKPSENIALPDSLLSRFDLLFIVLDNIDPESDRLISNHVLKMHMWQNDVANDPNFSNTQDEKDDQDFDIFLNRNPFEEMTKKWQKKKSQKNKRYQTRKSSQRNSKSESKSQNDDDENFEQKKILNIDFLKKYIYFAKQKIVPKMTNEASEFIASFWVGLRSKEGIKTQPITARTLETLIRLSTAHAKARLSDIVTEEDAKGASDIINFALFHEAEPKKAEVKRKKRREPVQIENENENEIKIKIENENENENENENENQNQNEIQIENENNSNAIEMDQEIDSQTKPNLSKTKDRLVEFRKLIANVFKKKRTNEMQIEILIQEINETKPNPLYDFEEIEPYLHQLQEENRLMFSEGVVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKX5</accession>
    <name>A0A9Q0LKX5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKX5"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="3">
        <location>
            <begin position="206"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="380" mass="45364" checksum="472A115A70DF449D" modified="2023-09-13" version="1">MVEKEYFDRSDMGMKKAIIKKPIVNTTENIIYPSIITEEFCNQNGLCWHFFNKGFCFKTCKKRHPHQFLRCKYLDTQTGCTNPNCKYQHPNPLNSYHLSKIEHENLQITFDSVDDYDKNQIQNQKKNQKKNQKKNQKKNQKKNQNENQNENQDKNQNKISHSKFWFKSPFRTTERTNCEEFEKNGICNNLNCKYQHRCGQKNILFLDDKGKYDNYKSIPQNYTLRNPTESEKFMIENIIQAQLEKEESKIKSIKSIEIIENEFLETRFKYIHQINKESKQFLGILWGFHGTKQDAVDPICKSGFDANHQIVNVHGKGTYFARNPNVSVWYCDDSNQMFLTQVCFIEGKYIYQKKHQFYIVPDIELLRPFALIKFERKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLI3</accession>
    <name>A0A9Q0LLI3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_07722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLI3"/>
    <dbReference type="OMA" id="FFRCEDD"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5075018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="373" mass="43129" checksum="A00D538A6932A51C" modified="2023-09-13" version="1">MQKKQKIFPELKGKFNIIEKVGEGAFSKVYKAQNKQTGEIVALKRIFPTSSPERIFREAEILYKLRGFDGVCYLSEGFRQEDQITLVTPYFEFDEFRDFYHQLSIPEIKKYMISLLEALKYIHSKEIIHRDVKPGNFLYKVDKNHGMLIDFGLAQTKNDIIELSKKKLNEINEFRKQNNIGFNEQNQITFIKINENQINPIKQKLVANDQLTSIQKEIFSNPKPKKEDPRPILKAPRAGTRGFRAPEVLVKTYQQTSAIDIWSAGVILLSFLSGVYPFFQPLDDMIALAELVAIFGTEKINNMAAKFNRKVVCSNEQKGEDLKTVCKTINKYFDELNPPDSCFDLLNKMLDPDPMKRITAEECLIHPFLLDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM16</accession>
    <name>A0A9Q0LM16_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Centromere protein w</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM16"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="98" mass="11671" checksum="7ABBAB30E2DCE453" modified="2023-09-13" version="1">MIIENKNSEGLQWEEIKGIDLDLFEEVISESRNSLQKIDDVLCLVEYLYFLKLLAKECEHDAQKNEEKKITKESVDSVFPVTNFYFYFIKSHFKKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMB0</accession>
    <name>A0A9Q0LMB0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription and mRNA export factor eny2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMB0"/>
    <dbReference type="OrthoDB" id="6221744at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="131" mass="15893" checksum="3780B6FFBCD3472E" modified="2023-09-13" version="1">MNRRKKNPQKNKKKNPQNQNQKLIQNNQQIFDKQIQEKPEEFFDKLKFQFENSKEKKNIEETFRKKLIESNWKQKMETFCNELIESKGISNISKEKILKKMIFEGQLNVPLELRNELESSIRSFLETIQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMI1</accession>
    <name>A0A9Q0LMI1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fimbrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMI1"/>
    <dbReference type="OMA" id="WNSYIPI"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21218">
        <property type="entry name" value="CH_PLS_FIM_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21219">
        <property type="entry name" value="CH_PLS_FIM_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21220">
        <property type="entry name" value="CH_PLS_FIM_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="68"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="218"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="345"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="464"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="577" mass="65806" checksum="D2434CAE1C5FB100" modified="2023-09-13" version="1">MRRKIEDLNQKIQNLEEENKILKEKLEFSTEIIATDKEKGEEIEEENAKLKETIENLKGKIESKRSVDLLEKELVGYINLRLKYDRDLINILPIGTKSADLLEAAKNGVLLCKLINDSFPLTIDNRAINYEINEESSLENHNLCLNSAKWIGCNVSEIEPQSLLNGDESSILQLTWEIIKLGLFSNLKIIKHPEIVVLFDENNKKGLSQELIDEINKIPPENILLKWINYHIHRAGEKRIIQNFSEDLQQPIVFATLMNQLSPQLCPLAEFAKETDPDIQAKMIEKFASNLDCKQFISAQTIMSGKYDQLNAAFLALLFHTRSGISISKEQAQKIVFDDHDRAGTREERALRIWINSMGIQPKVYDLSKDLRDGLVILKVIDKIEPNLVNWKKVNLVPNDVFKKLENCNYVIELGKSLHLHLINISGENIQEGNKTLILGFVWQAMEYHIKTILTKLNVIQSGRITDKDIVTWANTKIESAGKQSSIPNFKDRSLQNGIFLIDLVYSISPKAINYNFIQSGNSDEECMNNALYAISLCRKIGASIFALPEDIVEVKSKMILIVVGELMRIDKLINQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN24</accession>
    <name>A0A9Q0LN24_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein rcc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN24"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="277"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="368" mass="42533" checksum="938D0409FA9FEF8C" modified="2023-09-13" version="1">MIYSNRIINPKLYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELIFKNETDNKITKPIQFKFENENENENENENEKQIKQIAICETSIIFLFENGKAIEYLKDSKQNPAKIQIKNIQKVFSSGSEVGAILTIEGNVFAKGDDINPNNPKEFINISSLIEDTNDRIIKDVVSGRSTIYLLTSNQNAYGIGSNYYDQLGFDSNVLKKTEKPILMMKNVSKIFSGNSSQFVFLLNSNQELFVSGDNEYGQLGLGKSERNEKKIKKLTKIQNIPKGKIIDIQCGWAFSIMLIENENQNPKRKLTHEFTEIKSSLFENDDNILDFSVEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN99</accession>
    <name>A0A9Q0LN99_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN99"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="9802" checksum="FB77C95C36A13AE8" modified="2023-09-13" version="1">MKKFQKEIQNNLLINSLRHNKTFSDLLELIVQQNGILAVPHSMALGTMSFTREFIETHILITNENHPNNFVTINGAIGLFIKAKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNC6</accession>
    <name>A0A9Q0LNC6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine-protein kinase brsk2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_06844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNC6"/>
    <dbReference type="OMA" id="HENTICH"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5075982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="609" mass="71081" checksum="A59B07F71BC468FD" modified="2023-09-13" version="1">MTTHVGPYLLGKTIGIGSTGKVKLGIHKETQETVAIKVLPKKSITQMPEVIKKIEREIAILKLLNHPHILKLYNVYETTKYLFLVMEHVEGGELFDYLVSKRTISHSEALFFFQQIIFGLHYCHKHHICHRDMKPENLLLDKNFHIKIADFGMANLMKHNSLLSSSCGSPHYASPEVIVGKEYDGFAADAWSCGVILFALLAGRLPFDDSNIRRLLARVRSGIFTFPKHFLEEEKDLINRMLTVDPEKRITLKEVQKHKWFTSNFASTYQVPVPPFDLYQNESIDPILEMNPEILLFLKSLGFQDQEKLEKALKSKEMNMEKVFYHLFQIKIERMKEEEKKSNEKSNENPNVNLNNNLNENQNVNLNEKSNENQNVNLNNNLNEKSNENPNVNFSTRWNPIPKPSNNYQQEKFDVNQTNSVKNLPTQQIEIDDPSFRYDEFFPYGTPTFHRFKITPMSSSPQITTDSPQTNWFGSWFTEISHQKKFMSQNSFDSLENLQTDQNDISLEKIFVVSKKDSYYRFLAKIQKALILINVNWIHPHEFSFRIQIPNKLHFVIKIQEDSTLKNRNSTLNHRAMFIWKNGDLKLFQEISQKLINILKKKKGKQNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNY6</accession>
    <name>A0A9Q0LNY6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNY6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040198160" evidence="2">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="84" mass="9792" checksum="A6D42C2CD795085A" modified="2023-09-13" version="1">MLIIKLLLIQILFSIIMTKTNKEQETKTTPIYLGVIFISILIFVFILSICKKKKRFIVPEPDDPGWEKVEVTEANVQDQRIDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP14</accession>
    <name>A0A9Q0LP14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic nitric oxide reductase flavorubredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP14"/>
    <dbReference type="OMA" id="PNTPIYC"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07709">
        <property type="entry name" value="flavodiiron_proteins_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045761">
        <property type="entry name" value="ODP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43717">
        <property type="entry name" value="ANAEROBIC NITRIC OXIDE REDUCTASE FLAVORUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43717:SF1">
        <property type="entry name" value="ANAEROBIC NITRIC OXIDE REDUCTASE FLAVORUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19583">
        <property type="entry name" value="ODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="4">
        <location>
            <begin position="30"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="432"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="581" mass="65786" checksum="7474243C608A1EE3" modified="2023-09-13" version="1">MDLLIKQQKTNKALETIIKKQIYSLGRYFGTLNILDREGKKHKIGYTNGDTLYEAAKKAGLNSVLGICGGNMSCARCQVYIDEKDLPRLPPMSQQEQDALTHAYKPNPRSRLACGLVLDTNTNGLSIDLAPLKPKKIRKKIQKPKETSITITDSSVVSYPFSEPFLSLNPDSLETVENYQTVKIKEGIHWCGVIDWDLRDFHGYRTTRGGTYNSYFIQDEESVLIDTVKQPFVERYLKKVKSLVNGDLKKIKYLVCQHVEMDHSSALPSVMQACPHLTVVCTELCKQVLEKHYDISQWKFKIVADGETLKLGKRSLTFVATPLVHWPESIVTYMPEEKILFSMDAFGQHYATTKRFDDEVDFSIVLDEMKIYYANILMRLSVPIKKALKNLGTLDISTICPSHGVVFRQKENISKIIEKYTDWANFKKKPHVILFYDTMYKSTQRMINEVAAGIKEVSGVTFDIMNVRTNHITDIATGALDCAALVVGSPVFQEHSMPEVICALSYLEALRPLDKLALIVSSYGWSQSGAANDISRYLDSIKAKQIRDPIFSFYRPTNSLLKECRDAGKQLALEVKKVCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP15</accession>
    <name>A0A9Q0LP15_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP15"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="334"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="502"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="613" mass="71454" checksum="80207F50D4C3F958" modified="2023-09-13" version="1">MNDCLFFGSNQNPKLIKNETEKIKKPIQFENENENENENENENENENENENENENENEKQIKQISSSFLSTIFLFKNGKAIEYLRDSKQNPSKIQIEENIQKVTAGAQNEAILTKKGNVFAKGEYINPDNPKEFINISSLIEDKNDRIIQDVVSGAHTVYLLTSNQNAYGIGDNYLGQLGFDSKTLEKTEKPILMMKNVSKIFSGNTSNHVFLLNSNQELFGCGWNKYGQLGLGKSKKEETKIQKLTKIQNIPKGKIIDIQCGFTHSIMLIETDEAKRKLYSCSYYEFNGLGQNDEDENTYEFTEIKSSLFENDYNIIDFSVGNRHTLILTEKEKLIVFGSNYFGQLGTGDTNNQSIPIQIELPKLRFNENISNYHISCGYNNSFLYYSSPSFSNLEEDLIKLFKRKEFCDISFKTENGEIIEAHKLILKYRLNQNENQNEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIEKKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYIELSNKSFQIFEYWIYSNQIKDEIQITQEIIEEIKSGIDYFQLNQTNPNLFDLLISKFNNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPJ2</accession>
    <name>A0A9Q0LPJ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Box c/d snoRNA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_07958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPJ2"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5074915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="172" mass="20557" checksum="C16C6A5BB3B930AF" modified="2023-09-13" version="1">MSENKFICEICQEKSKYTCPSCGMHTCSLKCYQEHKAKFNCSGKRSKTDYISLKNFDENNFFSDINFLEECEFVMKRQKTLKSKPNNQIRKLPFFLQKLIKKAQNQQIQPKKSIQYNLRFKTIIEYPIIKVCSLEEFSKLKISVENQANFDNINYIRFEQENEIINKDEQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPX0</accession>
    <name>A0A9Q0LPX0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small rab-related gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPX0"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="157" mass="18058" checksum="710FC27FEA69BAEA" modified="2023-09-13" version="1">MSKVLKYVLVGDSCVGKSTILIQFCDSFFAKNQEPTIGVDFRFSNITVENEEIELQIWDTAGQERFRSITNHYYRDANAIIVVYDILNKITFSNLEAWYSQIFSTAPETTKIILVGNKLDLQDHRTVSKDMGEKVSLYKQNSKKYSSLSLYILNFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ14</accession>
    <name>A0A9Q0LQ14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-binding protein ipp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ14"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="550" mass="64760" checksum="F1FBDB20343750B8" modified="2023-09-13" version="1">MSMKANLIDLVSDFRKIRKDKTNAKGVIAIIEGKEEEKLHKEFVIHQCPQLRESVLRSEKHKKDYKLDFTKVKVEEKTESIKPEVAEQILDFIYTGEIEIDENNVLEIYKASILLENEQLAFWCEDFIKESITNENVIGYIQVPWIRKNAVLFSTAMTRFEHNLSDIIHSKDRKWTLLPKEVIISILDSDNINIYSELDLFEMVINWIVHKLDGEKAREFRNLWRKRPRRMKENAKKMFKEDFLKRIRFPLMSKGELGSVDTFHIFTSGVIENLRKYATITTILPWLEDEAKKVKDEEKTKLENSLKNESPEEFRLPESAFKPRRFSSSKIDIPIQDKSDQSYNSTQIKDLIKDIEGVGKENFDNPIFSTKKDRFSVEQLHENCKDIKSSWFVFFTTDKNDIIMGFSTKGDYFSDDNSYYVHDDKSFIGVLQVDGTMLTKEQFKKYGLLELIKKDNNGNGHALIHAKDHGPIFGDYDIGISETLLSCYSHWGLEYLPYEFHDKNPYSSVLSNPRFWEMWFISDDKLEKKMGTFYSRKRHRIVDLKIFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQI3</accession>
    <name>A0A9Q0LQI3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQI3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="684" mass="82385" checksum="BAD46D4A48939930" modified="2023-09-13" version="1">MSFTFLLTLFQYTNDFDLTKKQNKFIINEKRFFPEIEHINDLFEEYQNFILNIHYIIQDSNKYSKIKNEEIQKYISEQIFQEYDFFIIKHLENIQEKEQIKKKFDKIFKMDIQENEEQNKILNPDGYYYGYFVSFLNNQVEDLTRSFNWITDKLTNNRQIVDQQENIKNSVYKICRDIETINEDFEKVLLIIIETAEKYLMNKNIALPIFNDEMNNFPNNRNMICENILGINNYPEPNPIFTLSDIDFIIPTRIARIIHYSLLFLLLKNETNETNLNEKLIYHEIKSLSIILNLSITNTKIYYILFLKEIIKVQDNQIQFGRLSKQIDNWKEALYKIYKEKHENILSKIEISTFKKPFKATNLLLTNPISISNLISNFLKKPENIENNIKKYPLISFFIQNYLKFKMIYLFPSFIKFSSFINIKYNGKINLKQSQKINIEDLFKDSKEKEIEKLNEEEIKILENWEDDFNECWIISLSQINNDKINEVFQIFIETENILIIINNFQFKDKIILNTSFLDESKWKQINLSQDTWNEILIKHLLNLQKKTRFQFELENIKSIKKLKIQHLRFIHNDISQHFESIIDKIDNQYKNQIPTTFLNQLDSFFEKISITNLILIFQNFFSKELIQKNYSPEQELLNNLVNIGDLLNLKTESEIIRKHFPRHLTLKYSVSVYLLCLDKLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR46</accession>
    <name>A0A9Q0LR46_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR46"/>
    <dbReference type="OMA" id="PGMDMFG"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000205">
        <property type="entry name" value="2'-5'-oligoadenylate synthase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000001">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="407"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="458" mass="51864" checksum="96922FB1A1959984" modified="2023-09-13" version="1">MTEITINVKLSTGSLISIEVNKAWTITELKEKLAGVTQIPAEQQNLVFAGQVLKDQREIESYGIKEKNTIYLVKRAANKISQGLGAKPKSTTTNTTNPTNTTQTQQPQQQPRQQPNNPFGGLGGLGGLGGMGGFGMPNMDMNQMMEMMNNPLIQQMMDSMMQNPQVLQMMIQSNPMIQQMINANPELQHVFNNPEVMRQVMDMIRNPELMQQMQRGLDLQMGQLSNLPNGFSQLRSLYDEFQQPMMDAMSQRNTDQESEDVQQTEQQQSTGIPNTQPMPNPWSSQQQSHQSTQTQSQNPQNQTRNQSQNQSQNSNPFNFQGMFDSFLNNPDLMQQMMQNNPFLSGFQQPQNQSQNQTQNQTQNQTQNRNPFSLDFLSMFNQPQNQTRNTTTQPTNTETDPNKQQTQPKDQERPEIRYASQLSQLNEMGFTDPKDNIEALISTGGNIQAAISLLLSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRD4</accession>
    <name>A0A9Q0LRD4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spectrin beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRD4"/>
    <dbReference type="OMA" id="QFRTEHA"/>
    <dbReference type="OrthoDB" id="10057795at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="138"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="851"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1011" mass="119643" checksum="D3F3678BE697F56D" modified="2023-09-13" version="1">MSVSKHSSLRYSTRPIANKTKDLQLHTQKKIFSLWVRKYLSKHTAFRSIRRNCEDGIALIELVQNLSGKNIPTYHQKTKTKMQKIDNLNYFIQFALDLTIPLEISPQDIIDQNLQKISQMIWTIAIFFRLKKIPANIFDPREILLLWCQISGEKYSIQINNFSSSFMDGIAFCAIIDFHKPGFIFPSVFTKQLRNKKRLKIAFDKATELGVPQILDPSDFTETRISERGVMLYIAEMYYLLATQKDIDEMTRRITKPEENSIENQPVEPLSPIEPPKIVKPTEMNFNQGKMKPKPPVRDGFQQRSRRSGKFSRKFQQIYQQIQKQYEDKIIQIFNVLKTTTNEMENVKEKIEEIKSGKILGNEMSLSTLDPEETKKKMVEYEAENRNFKKNIQESENKITSQQEQFRTEHAKVIEETNQISHQIEEEQNSRESRLEDIEKQSKENLKKTKEENKRLREKNEILHLQLENKRQEEQLRKQTDPEISQLQKQIEANEQNNAQIKMKLQKLETVTNEMEEEIKETKINIQKNQQVIRKAQQEIEQLNQNIRKEKETNTTNLRKKQEQIQDLRKRVEQMKSKSENAKLTLRKMLKTKQPKLGMELDKIEAQIEEGKKKEKQLAEVFRQEEYFSNVLEERNKRLHNLTQKKNEFQTHLQLGNKLQAEQIQLIQKETNELQQMIKDSAHSYAVKMRQLREELQNISKQNIEKDERILSIQETLQDMQSKYDAQEKLFGSLVEKKNQELLDLQEKFVGVQKTNRQLTSQLEEIVMEYNLELEGLKERVDDIKTVQEEKHKKKKSKTEQKFIDFVDLVLIKLDFEKQNSQQKQMNNDYQRLHEILMSKSEIIGSQRKILTNLQEKRDAKNSELKELENKYASLKAQFNNMVSEDSLFSEKNKEKLEKKIKIANNEKSIVRFERDLLDLQSRQTRYQEKLIQVESSLSSFKLLSTILSSISDTHGKINKILQQNQRLNDEQKSMGVTFSNVNEISDSIQFNEKKILRFIFTIQQIDSMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRQ6</accession>
    <name>A0A9Q0LRQ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRQ6"/>
    <dbReference type="OMA" id="AKAWCME"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="211" mass="24093" checksum="5FC4C700C34388F4" modified="2023-09-13" version="1">MSTRNYILKVILIGDSGVGKTSLMNTYVNQKFSDEYKATIGADFLTKELVINGSVVTMQIWDTAGQERFQSINVAFYRGADCCIMVYDITDHDSFVHLGDWKEEFMVQSAYENPETFPFVVIGNKIDCDNERLVSRNDVEQWCKQNGNLQFFETSAKESINVDKAFIAVAESALKREQESNIYSQLPENILLPDFEDETTIRQRKSRDGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRR8</accession>
    <name>A0A9Q0LRR8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tfg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRR8"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="400"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="452" mass="53090" checksum="5222BA9ABCBE10DE" modified="2023-09-13" version="1">MQSNNKITIKCCLGEDIRRFYLPKEAEYETLLLNLQQIYKIDFSKSSNFQIQYIDEEEDWITITSTHELYTAIQLISNNTPPVLKLQIFLKEDEDEINDNEDEYEMNDNDNEDEINDNDNKDETNSNQGFSFPFFPGYFFFQNLLGKDFQVIITNVLEIIKDKSIFDWFKKSKCEIASIFCQLVHSGAQGVETFKQGINELIKDFEFSLPETKKRITEIVNQIANHAGSLNMFLHQNLCAKMFQGCPNQDSELSNQSTDQQAQNGNFFGFGFGRNFGFNNKGFGKGRNQCFGARRGMFRGRRSHFRGRNRQHNFRNFFQPNSNQFRGNFYRNQSPFGFHFGQMNPYFPFPFQFQNVDQQNFQDDSQNDFDTQNFQQDELTNQMNEKLGLNDNQVDDFNSQKDDQIFPYMQQLEDLKEMGFPDSEEIRRLLIKHEGQISFVLNSLLSNSAKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS10</accession>
    <name>A0A9Q0LS10_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-16-mannosyltransferase mnn11-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_05755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS10"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5077656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="337" mass="40472" checksum="D3C95E324A14515A" modified="2023-09-13" version="1">MKVKEIQNNNEFQLKFNRKTTYTLIFIFFILSFTFFLLLKSTQNKNENENQNENQNEKEKEIKNKKQNWDLKKEKICILMVDDRTLGKNFDFSSNKQIPFFHTSIFANSFYSKYHGYDFYRIDSNNKINDSRKLLNLFQEHPTKQRTSYWNKLKIICLMMNYYDYEIILYLDSDAVFFDFEKTIEDFIVENVNYSENISLILTKDLEISLDYVNTGVLIFINNDFSKKMILDWYNLPITNPGFEFSLNVGSSEQPAMGEYMYKTEPWESHIHILPLNTTNGPDGEFIRHFWGAVPWEERNDQIFQIFINYSYHFHNFLEQIQSQNFSSQISKFIDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSG5</accession>
    <name>A0A9Q0LSG5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSG5"/>
    <dbReference type="OMA" id="NLLDFQW"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="506"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="770" mass="88926" checksum="A8DAC64C7B4DB149" modified="2023-09-13" version="1">MESLQKFKLEYEKYATIPTISSGKLFLNPKDQQLFSFLTFKQTHFPALTKTTFLNNYHIDLAQKTSIKIPFPIEIDNETLFAFSENGNFYATIKSTDENNTTLISVWDQHRKLFTQSIKDMHKKIYNESFFSCFSFSPDNSKLLYVAEFFDKENQKNPNFGNKSFWDNDCIRNQQDWGEAFSGLSTPMLFVFDIKQKTSQIVSGIPENISPGSGIWKDDNTIIFNGYEKPDVLMGIEYCYNRKSAIYQISLDKESPNLERLTTFFTVRSPRLNSTKTQLAFLAADEFKVHNNPVKLCVLDLQTNKIRVLVDVPKSKNVKDDYVLFEEKKIYFPGLFLHQLIENCWIENDTKIILNTQWKSTGKILSVDVTQENAQNQQFANVSFITDPSDDGVWSLLDSNHNSIIAKYSTPCLPYQVYYGNPIDFISSNMIQKNCVCLENSLDVINIDNDFEWSLHQIHVDDIESEYEMIVLQKKRSTKESEEKKYALVSPHGGPVSIYSTSFIFTNLFLCSLGYQILIVNYRGSLGFHPKILNSLTGKVGTQDINDVQNAVKFSRENQIISEKTQIGVIGGSHGGFITTHLIGQFPDFYKVAAVRNPVINIAIMSTTSDIPDWCTAETDIPKQPFTLNSDDLREMWNASPIRYVDNVKTPILMLIGNVDRRVPKSQGIEFYKSLKLRGKTTEIVIYEKDRHPLSRPETQADMFIRMALWLEKITKELQKNYKRITKELQKNHKIITKELQNNYKIIIKELQKNYKRIIKKNYKRITKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSS3</accession>
    <name>A0A9Q0LSS3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dctp deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSS3"/>
    <dbReference type="OMA" id="PVESMMW"/>
    <dbReference type="OrthoDB" id="2304873at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680:SF3">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22769">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="182" mass="20362" checksum="E17A70D3BAD5254D" modified="2023-09-13" version="1">MSNTVPEQISGSVLSAENILLAIENGDLSVSPFEKDNIHGASLDLRLGKEFRIYKEPENIVSVKEDADYKKITDKIVLDDKNKYYDLKPQTSCLGVTKESLKLSNKICAFLSGRSRFARIGLFIHFSSNFIQPGIEGPVVLEIFNSSNHTLRLFPDVCVCQVIFLETKGEAAYNGQFQKQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT00</accession>
    <name>A0A9Q0LT00_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT00"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="194" mass="22823" checksum="A72B884E66F161A7" modified="2023-09-13" version="1">MTNWDHYTPSAEYSGTWELYLGSSLYWGIFIFGLVVLIFAWRFKTKLKDNSIFFFPFASLLMLELFALFRALFVLVNIDWKLFGLAFFFYYTAPMACHFCAFSLFLLFLLGLIYYDPANQRIHRRVRILIHILMVASFITIIIMSAFSTEDNYTLLLYIISFILYAILSIIFLNCWTQVVYLAFAIAKEENNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTK3</accession>
    <name>A0A9Q0LTK3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTK3"/>
    <dbReference type="OMA" id="CEECCLQ"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="89"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="264" mass="31223" checksum="8684B9B96082FA1E" modified="2023-09-13" version="1">MKIEIEEKWKKEIEDKLKKQIEDKNKEIEEKLKKEVEEKLNQEKDNQDFQNENEKMKPIFDKLFTKYQKRIELKKKLEPIRKNFLQFSEIVKDIEYVKKLQKWINDNYFFSKMKKGFSAKRDGFSSQNWHSKVDNKGKTLVIIKTKDNFIFGGFTQVGFNGNTGEWINDSSAFIFSLRNDKGDRIPAKFTIKIPQYAIYSKSSYGPLFGDNDFELNSNLQPGYSNFGRSYNLPDGITYDTNEAKSYLAGSYNKWVVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTQ3</accession>
    <name>A0A9Q0LTQ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome production factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTQ3"/>
    <dbReference type="OMA" id="AWIISNK"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000002">
        <property type="entry name" value="Ribosome production factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="126"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="331" mass="39691" checksum="83FF6038E72B9479" modified="2023-09-13" version="1">MSEKSTKKTNHKLMKKPKQKKKITPQQRKERRKKFFNPNTIQNKMRNNQYIQKLKHEKKVQQTKERRKRRQLEKTLGDKAPPKQLPQTIDSTREFDETIVDPRDEEIILDNQSDEISSYFVEGKTPKVFITSSKKPTTNIYPFLFDIKKAIPNSKVYYRRRYHIKEIVKYATNADFTDIIIINEDRKKPNAMLLIHLPNGPTAHFKISNAVRRKEMKDKGRPVDSNPEVILNRFTTRLGHTIARMLASLFPHQPDFEKRQVVTFHNQRDFIFFRFHRYIFDSPTQVRLQELGPQFTLKLRSLQLGTFDYFHGEYIYYHKSLLDTSRRRFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2024-05-29" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTU7</accession>
    <name>A0A9Q0LTU7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="875"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1636"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2180" mass="263642" checksum="5488BD75B803E3CC" modified="2023-09-13" version="1">MSKLQKFVFEQIQKEKEVKLINELIYFFDKQKEEELNSFLSEIFCSFFLHNEKSPNLVSPVTFIDFFCLILNQIPQQFQILKEKKIYQKFNLLKKSKSIPSQILLAELKELDSIYIFDKRNHDISKPIIYEIGTNSQNQDFINIFNFYSYDKNHPFTYKIIERENVLERNKKKKIIIKKKIIPILHIEESKENLLKEECLRILEIAENQQKFERSDFYNTFLFRNKSHSIKKMFDSNKMMNVAKSENSLIWKTLLSIFRNIFDSKIIYQKFKEFIYFLIFSSILKLIQKEETKTISFKFYQILESSLQKYSNYICKIFQKQSTKIGSRWEIIKNLKNEMKKIQFFKPIPINIEELKQEYNVYFKNWKENINNQIEQIEKIQNYILRNQNSNLSLSKQEENKTKYIIDPLKFQKNNFTLKELLNELNQFQSFLDNLNSNQNSNQNSNYFIANLLMIIPTPKIEKPYSFYQIQNSIKNEETRNELFSLINHFQNFLKNIIEIEIGSSFFGLAVFNNLAILIRIIQIYDEIFETHIDQRIDKFKIHSEPFYQFYYQGNLFLNILEANKISELKQFYDKFGTKQNGFGFRVTNNLSSSDIQEEIQFLNSFVENEFSNDELISNFQIIVSPEIKKDDFIRKEKFYEKHFKNGIHSFLKTQIKEIKQKWEKEKKYLHLGLFYETQISEGEQGGNTFKTCEYYLKYFEQNNQSISDQSIFEKAKNNLEKRGNFDENKKLYTIQESLKNFQQILPKNEVEKIKNKINFLKISAFHLYNSSYSDRNSFRQWKENIGKHHSIFKYLLQNAFSNEELIKKYQDLFIYNRKICLIELGKFDEIIEEIKDSDSNPYYLFLKLWAYFQKNQFNEAIKIANILRNKFNEKTFNSNKLKELENKMKLFEAQKQFNSKNYSKSYELFSQVYSEYPDSSILKIFLFKLEQLQNFKKEKRRKLDFELKRNFQKLIFYELFCQQKEKYSIQIDSKDYYVQNLINFEEEIKKRNGLKIYKIICDSIFQTSKFVFKIVQRKYQQNQSRKIIESIESLYQPNLSPYISNLKPKENFIIDSQNHNPPIGRMKEKYISQSIKIINEKRREFEENENKKYIQENEIISTIQSKSSLELIEEFCLIRTKPLIQSSLLIEYLLSDISLLEKESFRIFVLLTFFEKDYLFKQIQIEPEIIKQIDKFLSILRNFIESSPHSIQPLLKFFYYFLKIYFNEYLFFSNNKNKNNSNSQNEIENEIENEIEEEIEKEIEKEMKKIEKEMKETKTENEKMELKMNLNFFYSLLVLLYQHYQNNPEKLKESQIEKCLLAKMRISFFGFKNENQQEIFLIQQKFDFFYFSILKIIFEKIEKKNIISILKNMEIISENEKFKRGSLSKNFPFINLKTKENNLYLINILTGELFKNGTSNIKKLDSYISDPIYKQIFGNNPLFQIQRKIIQQNSKSSNPIFLTTFEDSKNQKPFFQIIGNENNILLFKHQISIPNQNQNQNQNEKEKKILNFFPNNRKEIPLIFQNKNYLHWINNENSKIYIQKIPKEIQLSNDFVKISKWISETQPEYLIQKNSENNYELIEMKNSLKLINLLDQKNMNEKQKKSIQFLTKEIKSKQIKNFNNSSSQKILTIKDSNSKYFGFEKFDSILIWQGKSKINQNQNQNENQNQNQNQNENENENQKSFNYFPLKIEFPRYFHQSKIISFNFNEEKNEYLFSQDSRFHLISLKESTKEYEILNKNLLIQRKFDMFLLMKNEESNEMKIIIPVRSLSEDFKLFSWNTSNENPNTNYQCFIMKIDENGKILTNNEEENFFLSFLYLEHKCYEESIEYLLMIQPILPLSKLSFEIGFWILSQFTNQNLKFRDCHPYASSIRIICAEILYSNYFTKIQSKNIKEDFHNIFHNEMIYSWRKMEFKNFESFQTSLAINLNIYLNFGNLFIPPKIDYFYHFQRSKFFENIFQKFKFQENIYYLDSIFKNTFENYDQNLPFPQTFEFIYFESYLSYPQNISNQLLFSKTELKVKKSKLIPELKINIKEDFSKLISEFPKYFRSILQILCDPNSGIKENEELFLNTKVWMKFLNLKTNFNLKLKNIILDYWEKRKNSNSQKFKNPFLTQKEKWNDSSFQQKIDKLLKGFNQMNYFDKFNEEENLLNQIIKKTSENKNFQENNQLSNIQNFTYLEMKDIISQKEIQEKPKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUH2</accession>
    <name>A0A9Q0LUH2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Selenocysteine-specific elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUH2"/>
    <dbReference type="OMA" id="CFAIKGQ"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04094">
        <property type="entry name" value="eSelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03696">
        <property type="entry name" value="SelB_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000052">
        <property type="entry name" value="Selenocysteine-specific elongation factor EF-Sec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049394">
        <property type="entry name" value="eEFSec_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049393">
        <property type="entry name" value="eEFSec_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21131">
        <property type="entry name" value="eEFSec_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21208">
        <property type="entry name" value="euk_SelB_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="7"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="518" mass="58135" checksum="F81F047A73856144" modified="2023-09-13" version="1">MNLKSKPFNVSIAILGHVDSGKTTLAKMISTTKSTAAFDKSPQSQERKITLDLGFSSTKIPIPEHLQKRAEEMQIKEIQFTFVDCPGHASLIRTVVGGSQIIDMAIMVIDITKGIQTQTAEDFIIASIWTNKMVIVLNKTDLLPEEKLKKRIELLEKHIKKALSDSPFGNSPIVSVSALQSKGNELVMKELQNMIEIPERINTKNPFVMLVDHCFNLKGKGTIITGTIIQGSCSVSDTIEFPSLNEQRRIKSMQIFHEDVLQAEKGDRVGICISQFDSKLFERGIVCQPGAISSFTGAIALFNRIKFFKHPIKSRSKLHITIGHETVMTKFLFFKPPKEKKEVSFDNFTTDLEYLYVDEFKQEDSPIFALLKFEKKILALNNSLLIGGKLEIPLESNECRIAFSGQIINGFNWETESKSLKENLKIASFKFRTGLVDRVQDSSTLIGKDLFGKGAEIKRYSGTQVSIENKDGKKTDGTIISSFGKTGKFKIRIDSNDSSWIEVGNIIKMRKTKYVFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV00</accession>
    <name>A0A9Q0LV00_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV00"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="269"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="498"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="603" mass="69913" checksum="58D85E695DD5342C" modified="2023-09-13" version="1">MNEILFFGSNQEPILFKNESNTITKPIQFKFENENENENENEKQIKQISSSLFSTIFLFKNGKAIEYLNENDSNQNPEKIQIEENIQKVTVGGENEAILTKEGNVFAKGRNINPKNPNKFINISSLIEDTNDRIIEDIISGDSSIYLLTSNQNAYGIGSNQFGQLGLDSETLSKTEKPILMMKNVSKIFSGNISNHVFLLNSNQELFGCGWNFYGQLGLGESRKLGKATIQNLTKIQNIPKGKIIDIQCGLHHSIMLIENENENENPKRKLYSCGYSSFNGLNKITPYTNEFTEIKSSLFENDDDILEISCGSYHTLILTSNSKLIGFGDNRYGQLRTEDTNNKSIPIQIELPELRFNENISNYHISCGYNKSFLYYSPSPFSNLEEDLIKLFQRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNENQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVU0</accession>
    <name>A0A9Q0LVU0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rab gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAPVD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVU0"/>
    <dbReference type="OMA" id="KRITIWE"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF128">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="8">
        <location>
            <begin position="151"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="9">
        <location>
            <begin position="705"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="852"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="869"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5078795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="886" mass="102964" checksum="AF34216DCA25CB2D" modified="2023-09-13" version="1">MSRKRITIWEQIQEIQEILKKEKSSIDAEQKSLEAIKKKAEKLLQRLQTDLVEWTNMNRLSETLTETNVGFMLHSSKNELNSWKVEMYEFLQSPLSNIQRSKYQQMIQLLRDSPEILARAIILTPGLQRNYIETLSHSAIFSLFGNLCNDQEEFKMLILLKSCILEQLKLSPEPRTMLSSNKLLSRLLSAYVKNSQTQSFLISGLRDPMLALIQESSIDFSPQKEDEQKEGPDLVTTKLASFMKQFLDSMEKKIPLLPYGIRWLSKTFRNLCFLLHQERYGVITDIPITKTHKNNLTQIAKIFLSICSSKDDRRISMRNITQKIGEYDINISRFFAEIANVIDQVKPIEPQIENKKKKTKEDLFFVGRKPLLKSTLITPNDVYSLHQLIYQYATEVLPKTKDKLDLEAPLIKFILEFGKPPELIPAEHNKYLSLSLTLTLPAPPKLSLNTKNVVTKERGRSFFFSNKTNRSISVPKQDPVIAKKIKISQASFLQDAEKKFKQALWTIQFSNVESYKNKNIIDILRSEKEIAFASNSINQACILDATIRALEKITQNEKKLDQSSLMLKIKQSYFSRKNHLHNLVSQKYDYQGIVNRLEELVNQTESRMTSFDNFIRALVVRAFIEKYSDTLQDSIKIIKESSDLEILRKNTTDFFDSSQNILKMDPLCSVYSKTLRPLLISIQNHVFIQIHDFIFQPIFMKEQFEQEDNDFSIKMTEIRKKLTPQILQIPQEVWKKELWILAIEELMTLNQFKSPSLKIGVLAKCAKIINNILLFSGIREIGADLMLPIIIYVIVVTNPPNLPSNIRFVDIFGDRDVIDPEQDYWLTVFKSAYAYLKDLDLKTLDQPKNSENETRIRFEDDDYNDENINENNNKNNNNNNDENNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW30</accession>
    <name>A0A9Q0LW30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW30"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="179" mass="21286" checksum="40532F6412D26EF6" modified="2023-09-13" version="1">MAEDFHHTLQQFRDRRHFIKNLRTNTIKSWIEKGGNFDKALKNFSFKTAFASHLFNWISHSIFSSRNVTDFKERLMGCEQIWKSKEEKTHDFLNPTKYNHEIPKKNPYNLDLKDAASFLTQKLDDLTETYEHKLISTYSTTTLCEFANALIANVCPKARNMWRSYLLRVCISQIRWNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW59</accession>
    <name>A0A9Q0LW59_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Basic amino acids transporter-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW59"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="278" mass="30797" checksum="0E12FE4C10FA38EC" modified="2023-09-13" version="1">MFGKKQVKKEQPQVSFTKATNSVVKNTLEKMSPHWQTWLTGGTIGVLSELPGVFVDSLFNSKTTLSDAIKKFKDGLPMTFSTNAFLFFYYTAIKTYILKKTNLSKLPDNQKWKIGIFAGLGTCLAQAIIWVPVGNIRKQKEKARKEGKSSCTFTAIHDLGFEGLCSGFCETINATLPFYLSFFALSEGTAPYFSKYLAKNKFTPHQTKAVTFAYGAFNGFAAKMVSNPTEAARQSLFKGAKFDLSEVCKKSIVASISTGVRTGVKKFTFAPVFKMINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW64</accession>
    <name>A0A9Q0LW64_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000018">
        <property type="protein sequence ID" value="KAJ5079987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW64"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="147" mass="17428" checksum="5EF7C360C492AEF8" modified="2023-09-13" version="1">MESLLVRGYLYLVADALLYPRTKNYPRNFFFQFSDSEEEIRDFDSIKFEELQATNNEQRLEILTNFGFQDFLSLFQSVELDFQYQGRGARRMKQTNETNFLMTLFYDHACPILGVEKENIFYQKIFGVCVSLTNFEIRSGHSLSYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWS9</accession>
    <name>A0A9Q0LWS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mtl1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWS9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="122" mass="15007" checksum="6BC83D77F46A5CC6" modified="2023-09-13" version="1">MENKNQFENQNQNQNKNENQNQNQNQNQNKNQFENENKNQNQNQNQNQNQNQNQNQNQNENQNENQNQNEKKSKRKSILKINLKMKNKIKKKNPQETRFRRFRNLSKFFKRIISRRSSTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX08</accession>
    <name>A0A9Q0LX08_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000004">
        <property type="protein sequence ID" value="KAJ5080673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX08"/>
    <dbReference type="OMA" id="FSFVHPW"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="76" mass="9266" checksum="B80C92DDE2C8280E" modified="2023-09-13" version="1">MKMKIKIKIKIKIQNQNQNQNDNQNQNQNQNENENENQNQNQNENENQNQNQNQNQNQNENENENQNQNQNQNEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX59</accession>
    <name>A0A9Q0LX59_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX59"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="174" mass="20186" checksum="F644793D991DACD0" modified="2023-09-13" version="1">MIRIGGFLVSVTKNATAAHNSLKLIKKLYKSILKKNNIYIRFNDASPCPNTLNTFVQEGSVLYQYTTAYLVSQSENLQLCLDQVSKMGARNLGILVYIQQKVDDEKEDEKEKQNQNQIQIQIQIKIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXW5</accession>
    <name>A0A9Q0LXW5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thisbe</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000001">
        <property type="protein sequence ID" value="KAJ5080770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXW5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="446" mass="53300" checksum="7ADC2121A7F997B6" modified="2023-09-13" version="1">MFDNKNKNKHKKNQKQNKFREFVVFNENYSFSSNQESEILKNLPKNGCIVYSKELILFSQKIKDFHYIVLSNQDSEILIRHHVKKLSELVEFVLGNSPKEILEQTSQKLIHRLIQSYSILCSKFPLFLIDSKRVLHFHKKDKIIRNLELIYENNVKHVLLFFNDVLIYRFSRKTPIEHSNIINILIYINQILNLNENQNENQNNQNENQNENENEILNENQNQNNQNNQNNQRFSQINRQDLFLLKKSTLKNRSVVFHKKNQLLFVSIYKSNQVDILDFDQLNISVDLIKQKLQQPQITTEIAKNLQFAILNNRNKKSGNFYLGKNTKMEDCQELIKFSQNTLDSQENQTAILKRKNIYFYFQTWVQTQKRRRSSSQFIKPHLGFKSFRETQTLSKIFDEKIISKIQITSKSNYMEFYALFQDDNSQPNESEIQEYSKEIINLFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4B8</accession>
    <name>A0A9Q0R4B8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4B8"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10610" checksum="92DBCE0DC629BE33" modified="2023-09-13" version="1">MRSELYRGMFLSVNEYTSNKVTDYSELSDKSFQIFEYWIYSNQIKEEIEITQKIIEEIKTGIDYFQLNQTNPNLFDLIINKIKIKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R601</accession>
    <name>A0A9Q0R601_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectate lyase (Eurofung)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R601"/>
    <dbReference type="OrthoDB" id="5946820at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011459">
        <property type="entry name" value="DUF1565"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36453:SF1">
        <property type="entry name" value="RIGHT HANDED BETA HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36453">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07602">
        <property type="entry name" value="DUF1565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040478418" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1565" evidence="3">
        <location>
            <begin position="240"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112904" checksum="34F38FAB6D69F8F0" modified="2023-09-13" version="1">MKQQFFLLIFSLLFILIHIQTYSFKNVQTLDFLTTTPDLGNWFKGESGLTITYTQNGAQIPFSGTATGGFQSYGYGPIPSAFLKIQVDFSGASFVTPTNSDWWSLVKNSFRILQITNSDWNPLAVLSVFLNTEGVLCGEIDYTNSSDLFVWTYDIFEMSSSLQVLDITVGITLDKSIVVLVGNTVVKTLPVPNIADVGDFIVFSAGNLLSQLGTTTGHLLVKKVYFDVNYVSDLYVNSNSGNDQNSGNYYNPLKTIQRAFLLCSPGTTIHVADGVYRETITPPFNGLSSDRITLKADGQNAAIVGSKSGSSYSWVASGHVELDPAVKKAYIPDLDYTPYFVSVVDEYFNVLNRGFIARTPNYESHEEYNFTGYWLEADGGSAMAPLNCFPTIYNTCDSSYLSSYTLTHTGQRDSNPVNLKTIQDLTGGTIYVTDATTGHSIYKRTIASHSTSTGQITVASSGNFSGACNYIGLYSRYYVENKLHLLDSPGEFYWDNSTHELYYWPPSSVSPDFGNVEISGFRNYGMELSGFSYITIEGLKFLFFDESGIRERGGDTSKSWGVNILNNKISYCEWGIFINRGTGTGIKINSNWLIEGNEIDHINAAALYIAYYPFMGASWVQPGVTDMVVKKNNFHHLGLFHDWSMTRSGVAFTTPNKLTFTDNTIHITSHHGLLFTYNGYDGSNNVRTTDIFVARNTISSSCVGEADCGCIKFWTDETVGVPHYFNNALVVNNTCLNSIGFTTQSQHREYWNGKGGFGYYLDNAGGVAFYRNIAFNNGYNGFSFFKKWQETKSYIYNNVVAHSQVGIYLGGFASTSMNETMIQNNVFMDLENNGIFYDCQTYSVDSLKLFLDHNLYHRYCRNNDWGNGIMYATSGKYFYNLSQLYEDSEFEYWEDHGFDSLDPGFTYPFYDNQDYILSPQSVPPGMIFTTPYELVDKGSSSLPSYISSLLTHFGFCDVEVGCCYDLGSYEEDPANTCYPKNVSSSNHLSFSFLIFIFLSFSFLIFNFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6B1</accession>
    <name>A0A9Q0R6B1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock 70 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6B1"/>
    <dbReference type="OMA" id="EQHVTIR"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="844"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="659"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="869" mass="98021" checksum="B8922DBE9F0390D8" modified="2023-09-13" version="1">MIRISRQNFLKKISETNKRKTIQTILQKGIINKFFGTANNAGKIIGIDLGTTNSCVAVIEGKTPKVIENSEGFRTTPSIVAFTDKQEMLVGEHAKRQAVTNPFNTFFATKRLIGRTFDDPMTTKCMSMVPYKIVKGSNGDAWVEANGKTYSPSQIGSFILMKMKETAVNYLAQPISKAVITVPAYFNDSQRQATKDAGKIAGIDVQRIINEPTAAALAYGLDIKEGQTVAVYDLGGGTFDISILELRKGVFQVKSTNGNTFLGGEDFDKKLIDYLVEEFKKQNGIDLAQDKLALQRLREAAEKAKMELSTALQTTINLPYITADSHGPKHMNISLSRSKFESLVEDLVQETIEPCEKALKDAEMTPKNIDQVILVGGMTRMPKVIATVKSFFQKEPFRGVNPDEVVAMGAAIQGGVLKGDVKDVILLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQMFSTSVDNQVKVNIKVLQGEREMSADNKMLGDFELVGIRPAPRGTPQIEVVFDIDANGIVNVSAKDKETNKEQQITIKTSGGLSEAEVDRMIKEAEEKRDEDQKKRKLAEVSNDAESNAYDLEKKLSLFKDKIPQEDAKMFQKSLQDLKDVMKGNDIEKIQEKTKEVQDSNVKLQDLIPVKKITSQRNSNLFRNLSLNSNQNQNQNLFGNQNQNQKQNSFGNQNQNLFGNQNQNSFGNLNQNSFRNQNQNQNSFRNQNIFRTYNFPRNNKERRLTRKKRKITDSEIEQNPPEKRLVIKTTRKRFLKLIPNISQEELSVIPFFFKKPQVLDPSQAQIIPYVSPQKILLEIFKKYSTFLDKDISQISIEFEEDDLNSDSNNDMIFIEETNPQNSPNFSENEYENEYENEYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6X6</accession>
    <name>A0A9Q0R6X6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6X6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="223"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="397" mass="47670" checksum="17535BEB53B0C620" modified="2023-09-13" version="1">MDNNNNNNNQIENANQNENQNEMKNLEKKNNENLFNLTKEEIIKFIQFKQEKKKIFQFDFFQFLNNWIEKRNERLKGKKEKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIENKEKEIENKEKENQQMKIEIEEKWKKEVEDKEKEIEEKWKKEIENKEKEIEDKWKKEVEELKSKFELMELQKIFSDSEIVQDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGFKYSQSGEWSNDSNAFIFSLRNDKGDRIPAKFTYKQPQYAIFSRSDYGPRFGNDFQLSSNLQPGYSNFGYSYNLPNGITYQSNEAKSYLAGSYNSWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7H4</accession>
    <name>A0A9Q0R7H4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7H4"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="478"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="577" mass="65935" checksum="AD58E0DCB439E71E" modified="2023-09-13" version="1">MQESNLIFGAGMNDYGQLAITPKQNVHYFQKITKYDKEKVILIAAGYQNTLFVCESNKVYIHGLKETTFSSFFAEKPQIIQVKAGQDHFLILTEDGDVFGCFANSNGQIGQPSLNFINTPQKILIPHKVNSIYCSGQQSYFLLENGDLFGCGRNDSGLFPHSKPGNISTPEFITQSVERFFTGIYSSQYFFIRNGELFCSGNNSYGQLGLGHSNPISEITQISFFSGKDIIDISCGFCHTLVLVQEGESQKLYTTGYFDYNGLATPSNLTSFEILKEYSEPKIIQMGSGSQFSVILLESNKFLIFGYNDWGQLSTGDTSYVRQAREITFPEIKSDMQVEVICGSYLTFIKTRSEDFYQYRKILQGYNLKNALLQIFKNKTFCDIEIVSTDGYSINFHSLIAILRSQKPLPILIKNFEESSRDEINTFLTFLYSGIVGNTHSLKKMFQKLQIRRFNLKKNQEEIFYKDIAWLFSKQQSKDFTIICQNEKILVHKIILFSRSPFFLSLFENSLYSSFKSYEIQKGSPISLNHLISFLYSDTFDENIPENIINEIQYLATLFEIESDSLKKLTSKISDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7V3</accession>
    <name>A0A9Q0R7V3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7V3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="433" mass="51979" checksum="D077B2A6E3F93291" modified="2023-09-13" version="1">MCYSDISKEKFFAKWYKRITRIILDTLCFDNDNNNDNNNNDDNDNDNDNNNNDNDNDNGNNDNSDSDSDVKIDQIDNDRNPLKEYLKNFAKKIFDSKLHEKKKLFLDIIRFIFIYSASNDPHFFKDLVSSPKNNLELTYDNFLSEKYIEYITNFPQNIPDKENYKISVKQKIKFENEDDEIFPQDITALVHHRNNLINENQKMDLSDIETDLITLQSNLVYPKKKISQIFSFLDLLIRIIQTKGTPIQEHFIQKFEIICRDFKEHSLRGNQELRKILPYIFAKDEREFQNGEELYQKIIEKVNQKFIPTEIDSWCFYSFHTIEITLLDNLFSNILEKNRNRYPISFFYTENRKHFEFQIQNQIQNQNQNQNQIQNQNLNQIQNQNQNQNQNQNQNQNLNQIQNQNPIQIQNQNLNKIQNQIQNQIQNQIQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R833</accession>
    <name>A0A9Q0R833_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R833"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="99" mass="11852" checksum="71C6F573D08A884F" modified="2023-09-13" version="1">MSKHIRVVKKTKSVQKKKKLVDVDWNQVGEKYDPMNFENKENLQKKLDEFYQNLQSNDWETRKHNILQFHKILNGNTITDFSETLIETLGKFKSIFATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8M7</accession>
    <name>A0A9Q0R8M7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 3 subunit g</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8M7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="392"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="714"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="961"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="994" mass="118765" checksum="7FDAFB6220644EFE" modified="2023-09-13" version="1">MDQIEEQKEKEFFINFPNGNELFTIWKEIKSKHLTEINEKIIEFYILFQNSFQKWNPLRTKANRKIKEKQFEKSFEIEEINEAILQKEAHPIKFILFIISLLIYSKDFIKENIQNQNQNQNQNENIQAHKCLISLSIISILSKSKFNRQVLFENGILQIIQDLLEIIKNLFKLMENLRKSNSSLSIYYLIEIQFILSETMEILNQFLRERQVFPNQEILESTKKSKIIPSIIQCFQTNLNLRKSFIFSEKQIDIKLKFLQNFENFYELNLLTEKQKIELITSLLTFFQSPNLSPDLPNIGFANQTHENIEDFFQTNFFIFDPKISREENPFISQNFKNVKGNLTHLEFDFRSNVFQFIPKMIKEENIIEQISNNNNILYLGDFILWISYAFKPKFSKNLEELIMEIKEQEQEQQENKLENKLENKLKNKLENKLENKLENKLENKLENKLENKLENIQPKKVSEINLYNPYLDILFNNLRNLQMIENSNSNPNDSSKETIKNELDKFTNQTKTKVNSFKERLILTYLDLFKTEESSNSSLMHNLSNEKIIEIQQYIKYIYPELQMYILFEFKKIIIHQIQIGNENGNENENENENNQESLKFFQKNGGWEICFSDYFIRNNFNNLNIQENEKIKLNEANTNLQTLLIDLLLNILSIYQDDFDYKFLFNQVLKNQKIKSNSFLLNRFLEMIIEIIKIKPQISTNKIIKNEGFKQIQEILVQILEKNQKQNEMENEAINLCIKILESTFENANTELIFQNEEIINTLIDLFPHKITQKISLIYISKILEKTTNKNGEKEKQFISYLFQKILFLYQEINSKIQKEKSDEIEFKHLEKLFSKCSKSISKNRIVIQEIILSTNLLLVFKTLLNDKEQKSTYLVLSMLKEIIRNNEKMIYEFYNLISVSEFIELLYETEKEKPTKKLFEILLDLMIGNGKFSIENNFIIRDTNMITIILELYSQKLKQDFNQNLNQNENENQNENQNENQNLKIKMKNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8Q8</accession>
    <name>A0A9Q0R8Q8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8Q8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="131" mass="15282" checksum="ADBE6E56C166CFAF" modified="2023-09-13" version="1">MEYLCDKTNNFSTFPNPPYSIHCLMFQSIIQIHIVLSLSTYFNNQKVNLETGKIEEELNFECGKVVLHHIYIFQKSIFWKFNSCFYADGLEVNVTVKNSWFSKSFSISFQKCFSNDTFTIWKDLASAMVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8T6</accession>
    <name>A0A9Q0R8T6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_10565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8T6"/>
    <dbReference type="OMA" id="INTICDG"/>
    <dbReference type="OrthoDB" id="69496at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000002">
        <property type="entry name" value="prosaposin isoform X2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040437946" description="Saposin B-type domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="110"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="194"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="278"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="362"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="446"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="530"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="614"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="698"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="782"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="866"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="945" mass="106339" checksum="BCA0B0A7FDF3DC7E" modified="2023-09-13" version="1">MKFSIIFIFLILASLTFSIPQAKAPKGIECTVCEWIMEQVEAFISENTTEQEIEQFLENVCNMLPSPINTICDGLIEQYIPVIVQLLVNDFPPDQICTEIGLCTSMKAPKGIECTVCEWIMEQVEAFISENTTEQEIEQFLENVCNMLPSPINTICDGLIEQYIPVIVQLLVNDFPPDQICTEIGLCTSMKAPKGIECTVCEWIMEQVEAFISENTTEQEIEQFLENVCNMLPSPINTICDGLIEQYIPVIVQLLVNDFPPDQICTEIGLCTSMKAPKGIECTVCEWIMEQVEAFISENTTEQEIEQFLENVCNMLPSPINTICDGLIEQYIPVIVQLLVNDFPPDQICTEIGLCTSMKAPKGIECTVCEWIMEQVEAFISENTTEQEIEQFLENVCNMLPSPINTICDGLIEQYIPVIVQLLVNDFPPDQICTEIGLCTSMKAPKGIECTVCEWIMEQVEAFISENTTEQEIEQFLENVCNMLPSPINTICDGLIEQYIPVIVQLLVNDFPPDQICTEIGLCTSMKAPKGIECTVCEWIMEQVEAFISENTTEQEIEQFLENVCNMLPSPINTICDGLIEQYIPVIVQLLVNDFPPDQICTEIGLCTSMKAPKGIECTVCEWIMEQVEAFISENTTEQEIEQFLENVCNMLPSPINTICDGLIEQYIPVIVQLLVNDFPPDQICTEIGLCTSMKAPKGIECTVCEWIMEQVEAFISENTTEQEIEQFLENVCNMLPSPINTICDGLIEQYIPVIVQLLVNDFPPDQICTEIGLCTSMKAPKGIECTVCEWIMEQVEAFISENTTEQEIEQFLENVCNMLPSPINTICDGLIEQYIPVIVQLLVNDFPPDQICTEIGLCTSMKVGGDDKCIICDLVMKYLEEFIDDPTDEAEVEKFLNEVCSKFIPDPYKTDCDTLIDTFYETIVKLLVSDFPPDKVCEAVGLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R981</accession>
    <name>A0A9Q0R981_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R981"/>
    <dbReference type="OMA" id="DESIGYH"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="278" mass="31161" checksum="13A2677FBCE428A4" modified="2023-09-13" version="1">MKSCSIYRKIGIIGTEEFTTKSKEGIIQFIAKPNSQNIIYYEAKISENSPKDGIIGIGFAPKGYSDRDMVGWKSQSVGYHSDDGGLFNSSGNPTLNLETYKKGDSVGCLFDLNKNLIQFTKNGNLIKESIVYRDNHLLIPTVSGSDKAVFYVNFDGPFSYDFQVSENSNQSINSDMSKDENVRKLLDSKIFSLKSDQISQLSVTLLQELEAEFSRSLQLIQNEISRKNSDLCVVCFDKSKTVVFLPCRHCCCCDSCSMLVTNCPLCRAKINDRMKIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9D1</accession>
    <name>A0A9Q0R9D1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein folding regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9D1"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="372"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="619"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="856" mass="101257" checksum="45ACBC419A93DE2C" modified="2023-09-13" version="1">MSFPFDEQKELKNCIENLSKDEETEKTTQYLSTLQQIVEKIENANLLVKINGIDSVIKFLYSNVEQNRANSIWIIGTCAKNNPKFKKFFLNKEEAFRKILSFLSDPKETEKIKNKSLGTVSALVQHNIDWQNLFMELNGFDTFSRLIENGNQNNKNRAFFFLTQLANDENNGTIFQEIMGNLPGFLNNITQILRQFVDDLYKKEQELIQIGKVEDLESHIDINFLDSVLSFIDSITVNNKQNLTIFQQLCLPDLLTGIAFNENISEDTKKNSQIIMERIELMIFLSIIKQKKIKKEQRKLMLLQTLKSFSDEISEYCCQTTTNFQHNLFSIAFDSENLLNEWIFVIQHIQELIVQSNLKNASFLRNSPNESRNTPTGVALIQDKNENENFWQGWLKLIGPDLFIYQEENEQVASFKLIQEGIKIKKLPNHNLGFEIITKNQNYLIITPNHKEKTRWIETLLPIIQGFQQTIKRYDPTIKRAKNFRHISFQSPSTLFMNYAVNLENQDGDDDNEKENRKFKLNLKRNNKINQENIQNIRGNLFPNDSDEDDKFSENHIQEESKVDDSKNIPKLRRNTVSKNTIQQKQPQFPLKKQESERNLSILFESPFSSFHHLLNKFYHEENYEQNILQEENDQLRDQFNEQQDTIFNLSDNLIFLTQQIQEFEQQTKPKNNPEEKEIEFLSYHEFHRMNKSLFDEHEIYQEYYKNIINEYQITISEIKKLSKENEDPEIQKIINELMKDIQSKIESITEKLIPEEEIEKFKEEQEELTENLREYLESKKINLETYIFLLEKYIETIQEQRNEQSDFFSQQTHQKSRQIKSNQSDITTLSGKLEKKKTELSFSGYLPSNISNQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9Y6</accession>
    <name>A0A9Q0R9Y6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin heavy chain non-muscle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9Y6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="224" mass="26790" checksum="45DD859E32EE7C4A" modified="2023-09-13" version="1">MNKSQGELEKVRDSKLVLLNEIKEKLAKQEAEYLQFSESAEQTLSKKNQEFTTKVGEIEELKNQNKQISDELRKIETKLKEDQQKTEQINKDYSELLNSISEYDKDDDNLLITEKNQEITKLQEDLRKEQEELRKMITQKQTLRDELETHKFQSQKEIEKLTKELGKKKVELDSETRKKAKLEEDFMHLSQLFDLETKQELKKKQEEEQIIINQSINDYKQKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA39</accession>
    <name>A0A9Q0RA39_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Unc-13-4a isoform b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_09381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the unc-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099503">
        <property type="term" value="C:secretory vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052095">
        <property type="entry name" value="UNC-13_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45999:SF4">
        <property type="entry name" value="UNC-13-4A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="413"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="10">
        <location>
            <begin position="1324"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="940"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="941"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5072684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1500" mass="177460" checksum="F6C2D8BA3271B9A3" modified="2023-09-13" version="1">MQHTKSQRNWNILGSKKVATVRDEKDKKNQVGKDITNYFTGFLKATTQMVLPDQITEKIGIKDTINSGLGFIISLYDKQPQDENQIKNQEKHSKQLKQDENENESENENSEQEKKDEDEKYEKIDFDIQKKEEERLKNLQEEVKNIGIKEENLQIYSSLINCLLFPLRRLEKKDKNENIKNTENEEKHKIEVKFDPNYQYYYEALDGVIFPNGEQQITLKKITQIEHNLKSLIAEMKKTSLQQKNNLAFFHSLKTFKSKFINDVRKKIENHQKVTFIQLRDSFLQILKENLQKVQTVKWLNFEEFFMNQFDGVIQMASKEIIIEIQKLVKLFQSALGIIPKIHQRIIEEYMLNREPENSLFFLEQQKFYLKEHPFYSKNQFENESEYNNWIQKKTKIIDYSDLLVRNFLEIKNEGVKTLSHKSKKEKVPIGNLSIIIYEARNLICNDPKTSVNPFCQIEYETWEGKTTTSSGSLAPKWDPPEVFNFVLFDLDAVAKLTIRDEKSSNLLSKIGHLKSDKSPFLGEINLGIRSFMDKQSIPEWYPLQKRSSKPNDKVSGELRLRVQITFKQKISDIRMPRIVKKEKEYEIIFENVHFTFPNYHEYFKMFLKFFIYSSNHFFLHYKHEDDSIEPKGKNEDNQPKEEKGKENLDLNLNQNQNQNQIEIEYFSNQEHQISMDMKYKSDASCLYPNIPSNILLFISPELQKFIFDYCFQYQIEEPFFYLVYFHFLVENFNIHEQIKREVFHLLGFLIQIYKGKHMLKFRKNEKEYFISILKTFKKDLKLIVTHFSQFYPKNQPEHHLQLIMKVYEIIWELTKKDEKKNYISHLEKIISKGVLYNFQVIIASYSPKPQQESKEKLNEKPKEKLKEDIKEETKEILEKTKDNIKGILDSNLMDFEHISIKDDEIIQQSVDNIENIYNTSKENNQKQNIKQKQNEKQNIKQKQNIKQKQNQNQKQSIKMKRKRKVSQTATNRVAKMVHCVSLMIRDLAFLDTYFPKGEIFPAKFPLIRIFAENYLNLIIPKIKKALESKRTNLLVVFELYAKLRDLNEAISLLDIGEPKLKPIPVAELFFDSVKLWISESKEKLIEWIKRTVKMDPLEKITAENPHSVSIVDVFTAIYQSLEFLEGLKWKESNFFSILTIFTENISELIQFYAEENFKKVESQLSITEAQKENKFEKVVSKTRKTFSLTEKLCILVNNIEKARIYLNEFYQKIEEKIDELEQDPPRDSNQMNQFDISLSKHIQDMKKKLSDLVTKIKIAIEAEIQVGINLVFEKHYLKQHPNQNQNQSTSIFSILPKLKGKKGKEEKNKGKEENKETDEDYLNDILAELLLYLDKQLAVLMDNLYYSVFLVLIQMIHKCVINSIINAVLPFSCDLKESPDSKKIKFSHQPSDILIVQKMVAIIDDFFYADGDGLAKNKIDKNRAVFDLFVSLFQNKTQNLIEIFEISKSDSPQFLRIAQSQNVEEKVEEMSTANFSFRILRLRAYYKDKIASNYLAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAK7</accession>
    <name>A0A9Q0RAK7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sh3 and f-bar domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_08861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAK7"/>
    <dbReference type="OMA" id="GMQTNDE"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="294"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="368"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5073179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="425" mass="47255" checksum="D1805F38BDD373B0" modified="2023-09-13" version="1">MSFRTDLWDCYDAVRERVTNDFHDLREMSEFLQKIAKTQEFFGRSLTKLVHGTKVGERCVGTVKEAWDTLLRQFDTIGQLHLETATKIMEDFAKPIIDFKNETSPIRKEILSSCDKKAKEVKNLKGKFENLTKKSMKIKSDVDNLNSSVQGGDNRAQGKLEKLTKTKSKLDDDVSKAQSAFESSEQDFLRNVVPSILDEFQRLEEQRVNKLKTQFKALASYHVTGFVSTTQQAFQKLSDSFEQIDADSDIKAIINENRTGNSNPNTSSNTTSYGGGFSETKTTSYSAPKTSYSTTGDQVTALYDYDGEGENDLSFSAGEVITVTNKHDGGWWEGSIGNRTGLFPSNFVDSGGGDNADQQDYSQQSTQLSGEQVQALYDYEAQAEGELSLVAGEFLTVISEDAGWYIGKNSNGQEGAFPGNYVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAR4</accession>
    <name>A0A9Q0RAR4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAR4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="464"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="569" mass="66784" checksum="5E7721EC80FB7292" modified="2023-09-13" version="1">MNDCLFFGRNYYPKLIKNEPKEIKKPIQFKFENENENENENEKQIKQISSGDFSTIFLFKNGKAIEYLNENDSNQNPEKIQIENIQKVTVGAYNEAILTKEGSVFAKGKDINPKNLNQFINISLLIEDTNDRIIQDIVSGYNSIYLLTSNQNAYGIGSNYDGQLGFDYEILEKTEKPILMMKNVSKIFSGNDSNHVFLLNSNQELFGCGYNDYDQLGLGESIIEEKIQKLTKIQNIPKGKIIDIQCGYSHSIMLIENENENENPKRKLYSCGNYLFNGLDKDEHTYEFTEIKSSLFENDDNILDFSELEIQKDKSIPIQIKLPKLRFNENISDYHISCGDYKSFIYYSPPSFSNLEEDLIKLFKRKEFCNISFKTENGEIIEAHKLILKYRLNQNENQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBA5</accession>
    <name>A0A9Q0RBA5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U2 snrnp-associated surp motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBA5"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="269"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="5">
        <location>
            <begin position="384"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="528" mass="62988" checksum="2B0E7A85B18442ED" modified="2023-09-13" version="1">MSSDTKKRKKKAGVDPRKIERFGQGFYKKVTPQQIKENELEEKKKHEQKMEQQILNDYIKSFGNSEQNEKENEDYLLKKRKKKIISKPKKEIDKFIEELEREKKYEKVIENDYHDFDYSRREYGDNYRSDYRNDRNSRHNSHGHHHNYHNHHNRHNHRYHHSENSGHSHSYHKFDGYQKDERNFDNSYLQNNPQNSFRTDSNLNLQRNNFHETKENTWNQDQFQYQNLNFENKMKQNNDQRINQKDFNNNYNYNQNYNDNNLYSNNETTAIYVSNLPREVQKIELISLFSPYGKILEVDLNDGFAKMIFTDGKSAKIAAQNLDGKFSFGNFLKVDVINEPTNYMENSIQSIIPEFSNLHLQGKIIGQEDWRWSTQEIKIDSTKMDNEIKQELIEMLQTISAERQKIKEGMEFVLDHPENVEEMIEMIKKSLTIFETPLKLKIARLYLLSDILHNTCSTSILNAPTFRRCIMESLPDIIQNFSDVLQTISGRICAQNFQKKVENVIRSWDEHTLLPESTIEQLLSILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBH7</accession>
    <name>A0A9Q0RBH7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBH7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF4">
        <property type="entry name" value="PHR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="440"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="536" mass="63053" checksum="682F04736B3C2606" modified="2023-09-13" version="1">MQKKTKNEVWFFGENHDFILFPNEPELITKSIEFEIENEFKNEFKNEKQIKQIVSNVSIGSQNEAILTFEGNVFAKGYDINPNYPNEFINISSLIKDPNDRIIEDIICGENSIYLLTSNQNAYGIGSNESGQLGVDLPTESQRPILMMKNVSKIFSGNSSSSVFILNSNHELFGCGFNRSNKIGFPSERREIKELIKIQNIPKGEIIDIQTGNFHSIMLIEDEDENENENQNQNQKRKTKRKRKLYSCGYYQYNGLNRKDDIINQFTEIKSYLFENDNILQFSVGYDHTLILTSKQKFIGFGNNEFYQLGTRNNISNYLIPIQIELPKLRFNEDISNYHLICGYHNSFLYYSPPLFTNLEKDLIKLFRRKEFYEIENQIEKLKEIISKKSIKESNQIFEMIYSNNSKINPKSYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKSKHIKFPKLILIMRSELYRGMFLSVKNDKSNQIKDESGLSDEAFEILEYWIYSNQIKKGIQITQEIIKEIKTGIDYFQLNHFKKENLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBK5</accession>
    <name>A0A9Q0RBK5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="KCENIRE"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1420"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1652"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2810"/>
            <end position="2837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2839" mass="336819" checksum="582667ACCBA64C6C" modified="2023-09-13" version="1">MKNNLKEEENFYSQVFKSISENPNPTIKLGELEDKINQIIKETLPKEKEEYFINKAFYSIVNSLWERNDFEEKYCERINNFFKKCLNLIYHKIQEENPQILLVLNRIFARPFHGFFEDYKKSTWKCNLERNYYSFWNKETIENSQEINQKTKFHFVQDSIDKISGYFLENIEYFGQIGGFEKIISEILSEKKEPISIFRIFDLLKPIEKISNYYTKEFLSRLIPFLQKILDNLTQLISKPLKKTEKSNIFKTADLIFEIIRSYSLQLKIQFETSFKMNSTFNLINSKDLEYKLIALEEIEKLLSNLNQLKSKRFRNKYLSTIKETIIHWIKEKEIIQLIFNNVISHEIIRKTKILLEFIGQNGFLNEFFNLIWHYSNDNHKIIVEEIYILLSSLSQYLSLENYNTAFEPVLKSKEWNNLTLFLLQNFGDGALKKHSKEKSENKQIWIEELNKFWGLVVNSELANKKKIEILECFENVFSSEDCSVDIVVTFIIQCFENLKLQKGNAYRYHLIFYLFDKFPQIQSFDNTVSNSVYNLIFRLDEENDISNKVFEEFKKFKSKPIPKQKDSGNVNEDLNQKILVGDMEYIEEIIIRLEMLKFILDHYSNMVLLKEKIDNLWEMFFENALTIKEKEYFLDWTTNIFYNNDLCEFFFQKSELFSVEDISISEFNFFRHFSQQYNIQKHKIKGENSIRVKIQEQDEIYGINKLWSIVLNAKNEKVANSSINYLIEFQNLAKGIFTSYGEEYRRKFIAKCIKILNKCKNPFQEEKINRILILLSTFINSVESDIIPEYIPFTRHMFSTQAQAKPIVINIKNNETTKYKLRATGNDSVFSLRKSISKLIKQKFGDFTILSHPQISSGNNSLTLFEVDLFQNPNIILDIPIKQDSYKKFSSQLRMDTGFEDQESEKSSTDHISEFDIDEQFEIESEHSKIKKEYLPSYLLARYFDEIFQLLEYGDEIAQKVWFIILRMPTNEKIIQSLKQIFDSSQEKIEWKQIFNTSSIHTFIYQLQVVDRLRNPYTKRIEEEHEQQQNEQEISGIEFPELEFIEDQETRKTNYWSIQFIQNGGIKFLVETIPEIAKTKEADKMENLQAVSIMMRIIYELLIDKQNIVIENQEYIQNINIANFVNILMDLIEYYSHPSKENNLDANHIVFHSISIILAGCSRRNRNKWINAIKKTKNIKSWIKKIFIESKCENIRENVYFGLHQICKKDTKMIKQQMQRKTDKQPYPIREFFLDLLFSVFGDIYNDNSLQTKLTKHFFQFVIDLIQMSLNASFERNYDEFFNQIATFLQRIFASEKKEMINVSEETLLGYLDILKVMLMKKKYQVEIEEKYQMIDLIINNLLFNPPKPISKAQDKFLLEMCKSETIQRVGFDFLIKIVRNSPQNFKKLYSHLKNLHKNIRSNWNYDPVSNVKSSLGYLGLSNLGATCYLNSLLQQFYMMPEFRMNLLSIDLEEELNKKISENVLYQLQLIFAGLTERELRYVNTKKFVSLLKLPNGSALNPYIQMDALEFFNIFLDIVEQNLQGIGRDSLVHELFGGKIRKEISNIQTGEVIEKEENIYSISLKVLDQINLEESLDLFVKEDIIVDENELSEKETNAYQRIYFEKLPRNLVVHLKRFEVDNETKQKYKVNSNFEFPMNISLEKYTKEGIAKRELEELERNENIKENTDKESQKKKLEKMIAEAQNKEYGYHLCGIIVHFGSTVSGQYYSLIKEREALNSENSLRWLKFEDTLVTLFDENKIGEECFGGENIYNTDLDGIENIDFYEKENSAYMLFYERDDVSRGDLTKKQQQQLLFEKSKIYDIVWKENEAYFYQKKLINPNYYQFLSDFIHEQESLIFPKEFNNEITQFALAFIFQIGLNSQHFGQIKTWITFLKKSFNEDEENDKYLLKQLISNENNWFQMLIYSTTDNSFLQELIEIICSSLKKLLSHEKKEMEHAIKTNEENQMRFENTLNFDQVSQLWHKRKRESPDLIATKFIDKFTEFLPLFLQNAINIQEYLTILKKFLSLNNLIRKYVLSTNLLTKLIDFYLGADSPLKTETTEKRNFKPHSLPNQMGRLFDIIFLLMKNLGSYRNANMMDIYMIEKSNFIEISINSHSSPDVLGAILNIIYEKNEDGMKQILDKIIHSIDSSEYNVIGVYFKMFRKLFESKNENLAKMTDYAIPKLFEVIKSNFGYKKATLESIRNFRLMLFNNTKLQDWMLAHKEEWVYLWLIEHPKHLIREEAKKLIQTLLPIEESTNSEEVSPKILDLFGFLLGMLPSITKNTYTQIKPEEDQKQKTSKMLSYGFFHLTTYFELLNLQYEKTPKMDQHLKDNFENLWSLFLHIEKYKLQYDSNKDFLIKFMETFMMGNEANIVLIVSDQKKSYQFLRTSFVLKDDPICVKYNQSMLPSFFSILRYGCSVSEQFSNVVKLSSRFKWVMKNVVLETDVYWDASNIVVQMCDIFASDPNFRIEYLNLILENVIYFSKSPRNTVNLVKIIISQENDISGFIKSLKKESNIMNVLGKFIIETVSLISGNELFSEDLEYYAHLIRICSKIILRIINAANEDAKLMEHLNQVWKKKVNLIRSVFWLLFNVNIANWKVIRVGLRLMTKLYAMISKDFIWFISYVQKNFEDEGVPRFFDLEEFREFIEVVSKSAIEKKEDIRNVFDAIGMLIEILESTVYYRDEDLFLKFIAILKGVLINSNFLQSKEDHNKIEESLIRKSQDFLGLILNHLKIIQFDDVFIVSDFIFSILFVKMEQFRLQSFFNNAIKQLRVQIQLGVEAKDEATISSSLKVFEFSGMVSYLKIIGFKEVEDLFIFLNEEVSKEKNQELIEQVERIIKILSNQENQENQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC86</accession>
    <name>A0A9Q0RC86_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Box c/d snoRNA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_07935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC86"/>
    <dbReference type="OMA" id="NITRSRM"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5074892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="268" mass="32132" checksum="DC35859482C8D129" modified="2023-09-13" version="1">MSENKFICEICQEKSKYTCPSCGMHTCSLKCYQEHKAKFNCSGKRSKTDYISLKNFDENNFFSDINFLEECEFVMKRQKTLKSKPNNQIRKLPFFLQKLIKKAQNQQIRLLILPSSMKKRKENQTNLNKKLNKIFWTICFEIEESKFLLHKIDENLELEIVFKNALEKQQEIKSKNQIIENLDKFKFLIKQEERPANDPAFFELEPKKSIQYNLRFKTIIEYPIIKVCSLEEFSKLKISVENQANFDNINYIRFEQENEIINKDEQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCD9</accession>
    <name>A0A9Q0RCD9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCD9"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="482" mass="56721" checksum="5B388A25CD8F9AB4" modified="2023-09-13" version="1">MSSLVFSDDEKLKKNLQNVFLNKKYTDFEIKVINPNNEKDIKIFPTHRAILMERSEYFNGLFRSKMKEEQQGFVEFNDISVQTMETILEYIYTGSLHINHNNALEILVASKKFCFEPKLTTQLVDFIRQNINNSNVIDLLNFANNFGYSDISACCFNYITWNPQPILESHQIREVSEEDLNVLVVNENLKVNEELELFNYIVDWAQFNLKLKPGIENLQEKDTAIVADKIKKLVSNVRFCEIDKEDFSRIAKMKIIPDEIVKMMNEFFEKNLTIPELLIFQPRSKFPESKIIGKNYEYIQLLKEWINDNEFFNKMQLGYGTDYTEYTTEEFHAHCDEKGKTLVIYISSDGDICGGFTKVGWTEDRSKWRPEERGTFKGNIIDPDAFIFTLKNPRNHPPTKFKIRKGKEEFAIWYEMIYGPCFGGIRTRIGDIELYSNVRYYFYFGESYEMPDGVHFGRDDSYTFLMSGSLTRFECFYIPSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCX2</accession>
    <name>A0A9Q0RCX2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_07119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCX2"/>
    <dbReference type="OMA" id="NICGSAI"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="12">
        <location>
            <begin position="211"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="486" mass="56804" checksum="9E3A9A496F7294D4" modified="2023-09-13" version="1">MHQLQNLPLFVKTFFVIFLIGQIIIFLTLNSKWMITKENDQQTSKEIQIIKQIEIKNKSCETKIEFCECEEEKKNSSTDLVAKLQEIENKLEMTKQCSSEYGYLLIKNWQESRIDICSGSKLSQVSCYKRENPGKHILCTGKNVEIKGYEPFFKAGNTAVPTRNNVHFGGGFLTVDCSQALKNWVPSDQWEHHVSNVIGNMISVPEMNCDHWVDDTVMLIFRWDQWNSYHALEDYITAFISLLILNEDPQKIQLVFTDDMPPGAQVYDFWSYYFAKEPIFLRDGKFPQNTCFKKAIFGMWAQNSILSIDFSRNWSKNCRSSIILLFKKYILPRFNISIEDNVHKPPYTIAFVKREDYQNKNIARKITNHDEIFKYIERKLPKDWSIVNFQPEKLTIEEQIQMSSRFSIIIGPHGAAFTYVVFFPEKSHLIEIFMGDRGSINVHFKNLCVFMGHHYHNAGHFSNNVPPETLWNIVESSIKEIEKLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD32</accession>
    <name>A0A9Q0RD32_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-related protein rab-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD32"/>
    <dbReference type="OMA" id="FYCRGAH"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001204">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="23931" checksum="82EA8B7341679873" modified="2023-09-13" version="1">MNEEEEKYDLKIILLGSSKVGKTTLVNRLTQGTFENPEQTTGATFSKKKYQGELQEYTFSIWDTAGEERFDSLSSFYCRNSGCELILYDITDRNSFTNLDRFFDKLQYTNEDSFVILIGTKLDLIEETSKLRKVTLEEGKKKANDKNSYFFEISSKTGHNIQELWETVGDLFEKNSQKNEIKHRQDNNHFQINSFTNNQKKKNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDA9</accession>
    <name>A0A9Q0RDA9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_06390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDA9"/>
    <dbReference type="OMA" id="RVYMRAT"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5076391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="489" mass="57763" checksum="1AA7BC4A7004E0FD" modified="2023-09-13" version="1">MIFQFFLSITIAILIRVFIALHSPKISEMNFEKQQQIMEFTTKNSIKNWFENQKTSNKQRIDFSPLSGYHSWLNGQIARMIDPQIVSRTHSKKDEGINQIFMRWTVIIADLVLYFPALALMVEDSSSNTNQAVQWLAMALQPALLLIDHAYFQYNSISIAFCLIAIYFIKLNKKILAFFFYSLAFFYNSNTLVFALPFVLYSLGLWISDSFDEEIDQNPKNKKIHPFMSNLFFLSILIAFIFLSFWFPFNNPKKIILENFQKIFYPFETQTNSEKDIANIWSVMSKIIPFQKRFSVLKLKIGSSILTSIFSMIINTHLFFKPTTRNLNLALFNTSLAFFLFGFQFNEEFILFPLIIATFMLQDAKIGLYMLWFILIGTFSLFPFMLTEKIFTPCILLPVLFILISWKIVSFLGHFKKLKISLFISVLICLFSLIPFFFQSSTKFTFTFTFTFTFIFIFLSWIFFLYHQFFPFNLWFLFQKKNLKTKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDL8</accession>
    <name>A0A9Q0RDL8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Replication protein a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDL8"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="306" mass="35697" checksum="71753566C5272DC7" modified="2023-09-13" version="1">MSENFNEYQKNPKTVGVFTIKQIKTTPTFKIDGILRENVVIVGFIISVESNPSSTKLTISDGTEKITVNYLQSDEQISFSIGTYIRVVGKLQMSLGQITISAFRIEAIKDPNEITSHFLEVIACHLYATRGSPNQYQNQNQNQYQNQNQNQNQNQNQNQNQNQNPNQNQNQNQNQNQYQNQNQNQNQNQYQNQNQNQNQYQNQYQNQNQNQYQNQYQNQNQNQYENENNEVIQKFSQIQVENSQTNLVDMIVQLVGSSQSEDGISFEQIYSTFQNYVSKEELKQILKKFCDDGDMYQPHSNSYTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE69</accession>
    <name>A0A9Q0RE69_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein son</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE69"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="708" mass="83112" checksum="91C822FEB43DC5CD" modified="2023-09-13" version="1">MEQNQDLFSWKGSLDLYKRLENISPTAPLSSEIEKIAIFASRNQKSYKWVVKTIEFFVTSSIRKEHKERTIVALFAIDAIMKKKSNREVYIKRFESVLEHLIEMMMKSNEGNWEPICKVLTLWKTKKIFSSQIMDKIISNGIALGAKEHFLLFGLEDSYLNTLESKFPSNLKPDPTMQKFQEVQREEEFAQFSNKFKPLEQNTQQNFHQIGIDPNLVSIGFDYGEDEDDEKRREEQLRRRQTEELEVNKDPIIISHALQTELNSNPFFDANLVDEITKSDPLNQVNQEPIEQPTVHIENNTHLEPPIPQFESYKQPSQQTEKLAQNFNEFPTVKQEQLIHTNREANPHKSIGEDFPPREIENINTSRRDNFTSETEDQIIPIEISPMTISNSNNILKKISHNSLRLKPYEQNYVQPFPPANFSRFSDFHTPPIQPPLPYPYPQIQPSQFNGLPMNFRGARPQEPHRRENYPFEPSYNQNQNQHYSSDRKRHFENDDFKQSSDYHDSEHYDYKRPADSHSKRSEISNEKDSYHQYPSRNPWNRWDDTGNERKHLDPPKNEKESPKNSHSTNHSHNSKNHSTHSHHSHHSHHSHHSHHSKERSRENSKNHSKEHSKENSKENSKENSKYNSKYDSKYDSKDNSKDDSKDNSKDDSKDNSHRSHSHHSHSNSRPKSPKNQSPSNSHSYSKSHSHHSKSNTLDKKEISNIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REK2</accession>
    <name>A0A9Q0REK2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REK2"/>
    <dbReference type="OMA" id="LHNRFII"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="343" mass="40306" checksum="FEA9D8A608142E69" modified="2023-09-13" version="1">MGNSPKKLTEFLEEEDFPKDQKLYGFSNIGNNCYINSVLQSLYHCEKFKEKIIEFKKNQTENEKETFLLENLLSELFCKINDSEKQIGSISPSNFVKKFLKKTSNLRYRRQEDAHEFFETLMDSFEQSIQKSDQISQKGKQELSLIYQLFSGEENSFIKCLECGSIRGPNVNKFVDIPLDIFLNESLQSCLKRRNLPEKMDGDNKIFCEKCNKNTSSEKFSKIVKFPKILVFQFKRFQFTMNQGQKKLFEKILFPFELKVEEESKKGIKTKHYDLNAIVVHIGKTIKRGHYISYSKVQDKWFCFDDSKVSLADPNLIEFTFGVSSLEPKKRQTSYLLFYTKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REW1</accession>
    <name>A0A9Q0REW1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein dek</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REW1"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="206" mass="24323" checksum="24D998E7B55C86D6" modified="2023-09-13" version="1">MEKKKRLKNQLQSFPEVYQSIKHFHKNNKLIESFHQFLFDKKEANISKSKSNILKFSGFGKDPKIISSFQSKLNNWKIIDLRNLSQLIQLKKIGSKKDIISRIIQFLSNPQEKYLKSKSRKSIQQFWNKNENKENESTNHKKRKSKSINHNSRTKTIFNMISSCDLDKLTVRDILNRLSIEFPNISEKRGYVDQLIIKALKVIAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REY2</accession>
    <name>A0A9Q0REY2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Gpi transamidase component pig-u</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REY2"/>
    <dbReference type="OMA" id="ALWHLWI"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="420" mass="49174" checksum="D095CDE2EE81946D" modified="2023-09-13" version="1">MNFKRIFGFILTSFLGIFIRTILFHFHFDEKFIKRIEFSTPFTNIRRLKEGIFLSQNGLSPYEGNTFHQMPILFYFFSLLNSLKSQKFIENLIFATTDFLCLILIFLISENHLQKKEFETKNKNFFFANFSIFLSLFCLSKTTAIFPQFFLLLTLFTAQKGWIFLSTFFLSCSVYLDIYYILLIIPVILLLRQKKKISIFMIIFLELIWVLSLLSLSITFLMKDQEITSSSLIEFTRKLLQNKKGFIHNSLLFSITAKDRTPNVGLFWYLMIEIFSNFKNLFLFIFQFQVVPLIIPLTLQFSKNPEFLFSIIALIISTFHPYAELGRMALSVALLLTNITLLKHMRNLFLVSSIFLFSISLLPLFWFSWINQGTGNSNFFYGATLALGLANIWLIGDSVHSALKFQFEIKNNKKNNNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFF7</accession>
    <name>A0A9Q0RFF7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ob fold nucleic acid binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFF7"/>
    <dbReference type="OMA" id="GHETMEN"/>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000072">
        <property type="entry name" value="SOSS complex subunit B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="2">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="135" mass="15720" checksum="F107FA44A24D277F" modified="2023-09-13" version="1">MKSSKNENLTIKIKDLQPKLRNITSTFIVLEKRKTFQTQHSQTLSTFLVADETAAIQFTIWDYDCSYIKEGDILFLTGGYTFLYKDQLVLYTSKYGSVSRIGEFTMVYVENNMSEYRWNSDQNGKWVSTPPNQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFW5</accession>
    <name>A0A9Q0RFW5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFW5"/>
    <dbReference type="OMA" id="NCDFWEA"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061118">
        <property type="term" value="P:regulation of positive chemotaxis to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001763">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="195" mass="22044" checksum="F17DE34CF8296C9D" modified="2023-09-13" version="1">MTEDNPLKIVLIGGGSVGKSCLTAQFLQGKFIEDYDPTIEENYRKVVNIDGEDTHLEIIDTAGQEEYRSVRDKYIKLGEGFIIVFSIISRTSFLEARNLHEAIRRVNNFQAVPVITVANKADLADERLVSQEEGETLTKKYSSSYYETSAKTGMNVNACFEEIIKQTKLFRKEKSVKPQEPSIYDEKSKGCCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFX5</accession>
    <name>A0A9Q0RFX5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adp-ribosylation factor gtpase activating protein 3 isoform h</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFX5"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="204"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5078564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="317" mass="37112" checksum="3012C9BC59E55797" modified="2023-09-13" version="1">MTTEEIKKELEQLQKKPENRRCFDCNMPNPTWASLGFGTFVCLKCSGFHRGLTVDITFVRSTNLDSWKSNQIKRMKNGGNFRALQFFKKNQIYDLDLDQKYHSKAALLYKKHLDDLCLENEDNPNDLIDNDSNEDDLIQNDSNEDDLNDTNDSIQNNSNNLIQNDTNNLIQNNSNNLFQNDTFKPQYLRKKNFQNRKNLSLRSFQKLKEQKSKINTENLSKEEENQFENQNQIQNQIENQIDKKSKNFNSLENSKCTTWNSFDWNKISNIIGSTFSKITKSGKKVINSVQKIANNVISNIQETNQFENENEFENENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG15</accession>
    <name>A0A9Q0RG15_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B-zip transcription factor (Eurofung)-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG15"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="105" mass="12624" checksum="E99DEB012DEBA44C" modified="2023-09-13" version="1">MNQKENEEIKKQNLELKKENEQLKQKIKELTNIYLSTLTQARLIIHQTMELLPDSQSFNQNQEPKTYSKIGENLSQKSKSKKIKNQKRKIKRIEEDKHKKKNFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGK2</accession>
    <name>A0A9Q0RGK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGK2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="109" mass="13121" checksum="E64AF3D6E2D156BA" modified="2023-09-13" version="1">MDILKQFYISQSKKEFNIKQTITSLLDNPQIETFTIKRKENIFLISKIFQHLFDLLILNIQQFSFISLSKTNFLTVYIITEIFSSNLINISQISQFFKINLFYLYYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH25</accession>
    <name>A0A9Q0RH25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mob kinase activator-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH25"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="434" mass="50741" checksum="89DA86C266CE97F0" modified="2023-09-13" version="1">MRILTKGNLVDFFNQVTMLYGSISEYCTEETCKVMSAGPQYEYYWADGVTVKKPIQVSAPEYVNRLMTWIQSQLDNEEIFPSRMGYSFPKNFMSIVKTIFKRLFRVYGHIYHHHFKEISSLGEEAHLNTSFKHFIFFMNEFRILDKKEKAPLRELIQHFIDKDKKREKENLGWWDNSHMIIIEIASRNLTTSQKNTLLDILSTWEPDFPGDLYAAAIWPDQIKQPPIKIDSMAGWHFADLVYNPDNIKVNYTLPPENVIVECQQALDTLKDKSCTSVWAWAFQLRQLFHFVGDIHQPLHCIDRFTKQFPDGDRGGNEFKLKGNASYEKNLHYFWDSAAGEYVTNYPLTQNQIAQLVANATEIMKNIQFLISKEDSVQQILILIDGQMKHIQQLLNMHIQILNQILHHQVVTLQDVSKFHKNKLLLLDIDLGLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHP0</accession>
    <name>A0A9Q0RHP0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHP0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="103" mass="12292" checksum="6F898A77F0694ED2" modified="2023-09-13" version="1">MERKEYKCLNCSKKYPENKLMVICKNEHLLCDECISNLDECPKCHNPLKAYAHHKFKPAKEKKIIPIEKTQKLDWFEKITIVITLIVLIGSVLHFYWMKQIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI60</accession>
    <name>A0A9Q0RI60_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI60"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="69180" checksum="96DEA93BB5415F40" modified="2023-09-13" version="1">MNEIIFFGENNFPKLIENKPNKITKPIQFKFENENENENENEKQIKQISTSFFSTIFLFKNGKAIEYSSKNPKRIQIENIQKVTVGHENGAILTKEGNVFAKGEYINPNNPKEFINISSLIEDTNDRIIEDIVSGYNSIYLLTSNQNVYGIGSNEDGQLGFDSETLEETEKPILMMKNVSKIFSGNCSNHVFLLNSNQELFGCGNNEYGQIGLEESRKESKIQKLTKIQNIPKGKIIDIQCGFIHSIMMIENENENEDENPKRKLYSCGKYQYNGLGKNENTYEFTEIKSSLFGNDDDILDFSVGHNHTLILTSKQKLIGFGYNSYGQLGTGNTNNQLIPIQIELPKLRFNEEISNYHISCGYNKTFLYYFPPSFSNLEEDLIKLFQRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYFEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIKITQEIINEIQIGIDYFQLNQTYPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RID8</accession>
    <name>A0A9Q0RID8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine protease rdl2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RID8"/>
    <dbReference type="OMA" id="HNGEYSE"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000039">
        <property type="entry name" value="Cysteine proteinase 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040188611" evidence="3">
        <location>
            <begin position="16"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="5">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="100"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="301" mass="33092" checksum="14751DCC25325D9F" modified="2023-09-13" version="1">MKVLILILVIVFATCTPYQPMFELFKQKYNKQYTAEEEAYRYRVFSQNVKKMEEHNKKGTFQLGINQFADLTNSEYQSKYLHPIEITRTGSTMKMSNVELPTTVDWRKEGAVTPIKNQGQCGSCWAFSTVGAIEGCVEIASKKLTSLSEQELVDCDSTDDGCNGGLMGNAMDWVAQNGGLCSESAYPYVAYDQSCKKSKCNSVSTITGHVEVTEGSETALATATADKGPISVGIDASNFSFQMYSSGLSVIPVDGSTPYWIVKNSWGTGWGIQGYIWMSKDRNNQCGIATYANYGTGCKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5I7</accession>
    <name>A0A9Q0L5I7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tata element modulatory factor tmf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5I7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="358" mass="40596" checksum="F8A08BB4DE14EECA" modified="2023-09-13" version="1">MGAVESAKKKITKKQSKQYIKKVQAYYEPIVLGDEKADFIDANPAAISLFKAKSKKQICSKGPNGLSADFQPAFNLPTSRAAPLAIQSAFNSPEGFFDFDWLHRDLDGKDFWVHVWATPINMGGKLVIQGLTRPVSGRGMVTTLDLGVDAAYFVKPLSDKIKSTLDTETESQIEQTKSSPQTDSETNTKTDPNIKKESKSDPKTDPKTDPKKESSPNTSTKAEEKPTHEVRKSIIVFPNDDLEMEFDEKVDYIKSLIRSHENPKLEKKIVDALNQAKSLFTRSNLLLQEQIEQLTQRIQTQEKKNRQKYFDLEEHLQNSLKSNKELTKKCEVLTSNFQIIRKLFNDPELEKIVDSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L634</accession>
    <name>A0A9Q0L634_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000142">
        <property type="protein sequence ID" value="KAJ5066490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L634"/>
    <dbReference type="OMA" id="HATEWKL"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="575"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="759" mass="89906" checksum="38CBA2C3F29CB5D3" modified="2023-09-13" version="1">MIYYLYSNYLPQREQVLFCDSNTTVGDVKNFFSIYKYYNEQYSNFKKQKQKEEEKVIFSIINATLLSQTSQSEVISQIRSINFITHFPLTIFVLEGEQNAFLMSQLQEGKLIINLENDKILNEIIKKSTFFQHFKVFYSQNEGDGKSYQIRKFCNSQNDKIDYKYYLIQLTTGEIQELIVELNKIPIEKKNENEELFIHIEFPTECSLQMTDSLWQLSMWGSIEDRQAKDPYNICWTLPPNAKLFFEIPSQNNIWKYFYPLQKFQPKECSCSVNEIKFKMYEVDEDQKKIQEIDDNDLKKVANLLIETQNNTLFNNFQNLDNWKQKLSTQNPDPNSFFNKSQYIIQIISNQLNPDHNFHKSFRLFYQFWNSLKKFINLILDWEISDDEDDYNNDDSQKKSFIRRQEIIRCWMFSVARLNLISFFSKQEGVFDNFYSFILNLQFENGNPISIYNPNIFGSVGEVGLFIKDNIGDYNFLEFEANLYLYSNSNLRFGDPISDHVNDLKTEYKKMLDFFSFLTSNKPQEIENSDNESSDDENDNNNNKENNENDTRKGKYVLTFDNLSKMMFIQFRMFTGFSLIISGETGCGKTALIEYLFRDILNYQFSKFNSEGNERKEKEKETNHFITFNVNGGTTKEKIKKLLEKSKKIGKQNQVVLFFDELNTAPKYCIPIFKYLFIDRLFEGKKIPSNIKFIAAINPYRERKSKAISENQNNENQNNENQNNEDQNKEEEVCGLLFDYGDKKNKEQEEIRNAVYPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L697</accession>
    <name>A0A9Q0L697_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_03112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L697"/>
    <dbReference type="OMA" id="KDDVRMP"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5066768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="141" mass="15352" checksum="6BBEC3A0625C9624" modified="2023-09-13" version="1">MSLSIPKQASAFRKGGFIVLKGRPCKIVGMSTHKTGKHGHAKVTFTGIDIFTGNKIEEAISSTHNLEEPYVNRNEYALLSINDDGFISLISDAGETKEDLKLPANELGEKIKAAIDEGKELLAVVTSSMGEEQITDFKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6M6</accession>
    <name>A0A9Q0L6M6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6M6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="27176" checksum="4A71E80012CAA62A" modified="2023-09-13" version="1">MKIVVYFDPEITKLLITDLNLIQFYFKIQTKQRNRKHKVITKTVVEKQEMKHFPFTNILFSDFDVSKYFKEKEKEKEKEIIFSFIKEKEKEKEKEKEKEKEKEKEMEEKILSEKINLKSNFHFTIFENQNKQNNSKINTNQVISHFLNFLFISLFIKMIQIIITTILIAILILKMIYLFLEKVFKLFPMFANHKFMNGFYFLSSQIFQKQIPFQSKKNLLYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7G7</accession>
    <name>A0A9Q0L7G7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_13125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000131">
        <property type="protein sequence ID" value="KAJ5067255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7G7"/>
    <dbReference type="OMA" id="YCAVFKK"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="304"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5067255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="669" mass="77476" checksum="6D4737D1D46FE184" modified="2023-09-13" version="1">MIIVKVKMKMKVKMKMKVKVKVKMKVKAKQYLPINQTPNISSNISSQKISSSGSFSDSDSDSDSNSDSDSDSDFKEESREKNSFLESYKNEKKVPFYQLANKKENLKGNSRKTRQKTRKQNKIENSENHHRSHKYVNDATLIIEGLKPFHPEIIEEAKMISTELIRIAISWHEMWFDSLDEASQYYFSEKNFPGMMATLTPLHEIIEKGGETKSEIEFLNDYGDELVTARENCRQFSKTRNENFISEAWENYFRCFRRIKKDISMIKSLKLETASPHLFDLQNSHISIPGTYRPGLKEIYIEKFDPEIVILKTKQRPRKIKIYGSDKLKYQFLLKGKEDIRQDERVMQLFGLVNTLLANSSTKSSTKTKLHLNIQRYAVVPLSPNCGLIGWVPHSDSLHDLIKEYREANGIVLNREHLGISDFAPEFHKLQIPQKVEAFEYALSLGDGMEINKVLWLKSQNSEIWLDKRTNYTTSLAVMSMVGYILGLGDRHPSNILMNQYSGQISHIDFGDCFEAAMERSQFPEKIPFRLTRMLWNAMEISGVDGIFRSTCEKTMNILRSNRDSLMAMLEAFVYDPLFSWKLNSHEENNNNNKKLKKLQTRSSTMLPLYLRNTSNQDSALDFENEETNEKAVSIVLRIVNKLSGRDFDGSIKLEIDQQVQKLIEEATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7L7</accession>
    <name>A0A9Q0L7L7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nsfl1 cofactor p47-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7L7"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="372"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="719"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="798" mass="94924" checksum="8621133E6DEF985C" modified="2023-09-13" version="1">MDGTLIENQFMNLTKCSKELAKAILSMHNYKLEDALKTFITTPINELIEKIQNFVGEKETEKKTEKTQTYKPKKLVYGFEDLEPEKKGKMQGYFVGGGASGVEVYDKQNDIVEKVVNHKKEKDNKKEDDKNEIKIENDNENENENDNDNENENDNENDNKIEDKIEDDDKPFEIKIEDNKKDNKIEEDKPFGIKKEDDKKEDEIEDDKPFGIKKEDDKEDNKIEDKKEDNKIEEDKPFEMKIEDNKKDNKIEDDDKPFEIKIEDNKKDNKIEEDNKPFGIKKEDDKKDNKIEDDDKPFEIKIEDNKKEDEIEDDDKPFGIKIEDKIEDKIEDNKKEDDKKEDKNEEKKEDNEIKIEDEIKKEDDNEIEEENFQIHTIYLWNNGFLIDESELLDYEKPQNHLFFEKLLEDEIPEQFYINGNPPKKFDYKIEDNRERNYYAPPKKVRVFTGQGNVIGHQKTQDEIIKIEKPKEESKEESKEESKEESKEESKEEPKEESKEKLMEIENQNQNQNQNQTMDVESQLKEENNENDPDLKNQLLNQMIENSQEEKEIDTGNKLGNLKTEEDDDSFFFYCATKTRNKTRTTNRTKTEQKQNKKQNNKQNSKQNNKQNKNQNKKQNNNLLKKLLKNIQKPIQQNEDFSKKSNDEFFQQFFQQFNQINQQKKQQNQQLIQQFVQTFSQMNQIPNQTKNQIPNQIKNQIKNQIKNQIPNQTKNQITEDLNQETSIQLQFFDGKKIISKFKLNSTISDIKNFILQSRPEFEQINFSLMTLGPRKIYTNDSATIKEENLMNSRIIIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8H7</accession>
    <name>A0A9Q0L8H7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gsk3b-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5068026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8H7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="2">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="103" mass="12358" checksum="134369A951450D6F" modified="2023-09-13" version="1">MFVDFESFEKEVEESIKEIKNLVKKCEKKNLNEKEIEIKIIDFEDKNFLIKIKNGRVYKLIEPKKTNTKFESLHSLLSYVSNSYNNNFTKNLFEAIEEMKNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8L7</accession>
    <name>A0A9Q0L8L7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8L7"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="313"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="389"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="483"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="69273" checksum="FF6E0911D59BF2A1" modified="2023-09-13" version="1">MNEILFFGSNKYPIFFKNKPEEITKPIQFKFENENEKQIKQISSSNYSTIFLFENGKAIEYLSENDSNQNPSKIQIEENIQKVTIGYRNEAILTKEGNVFAKGIYINQDNPNQFINISSLIEDKNDRIIQDIVSGYNTIYLLTSNQNAYGIGDNYDSQLGFDYKTLQKTQKPILMMKNVSKIFSGNCSTYVFLLNSNQELFGCGGNFSGRLGLGESRKEQKIEKLTKIQNIPKGKIIDIQCGNFHSIMLIENENQDENPKRKVYSCGDYHWNGLGKDENTYEFTEIKSSLFENDDILEISVAYKHTLILTSNSKLIVFGLNDCGQLGNGDTKNQSIPIQIELPKLRFNENISNYHVLCGAFYRSFLYYSPSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLKDYENQIEKLQKIISKKSIKESNQIFEMIYSNRIINSKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIKITNKIIKELERGIDYFQLNQTNPNLFDLLIKNLIIKIKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8N3</accession>
    <name>A0A9Q0L8N3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peroxiredoxin prx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_12355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8N3"/>
    <dbReference type="OMA" id="HGPMNIP"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="25"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="9">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="237" mass="26996" checksum="95291440B8E8BE53" modified="2023-09-13" version="1">MADHDSLLKEICDLKKKLDEINAMPLIGDKSPEFEAETTMGPIKFPQHFSGKWVILFSHPGDFTPVCTTEFMTFATMHKDFQKLNCELIGLSIDSNFSHIAWVRTIEEKIKYKDMEKVQITFPVIADSDMNVAKKFGMLHQSTSKTQTVRAVFIIDPQAIIRAIIYYPLSNGRNMDEIMRLLVAMQTSDKNKVATPANWKPGEDVIVPPPNTVEMAEVRTHQKSVDAKDWFFATKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L955</accession>
    <name>A0A9Q0L955_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_13013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L955"/>
    <dbReference type="OMA" id="HREIVCH"/>
    <dbReference type="OrthoDB" id="27341at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="6">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="215"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="383" mass="45405" checksum="223E367665883FC0" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFQNQNQKENEEENVSSSILSSILNYFYSGKIKINLENAIEILIFSSKYLIDELIGISSNFIKNHLQIETIVDILKLSETMNLNQLLDSCYQFIFENLDKFIKTPFFLELEENHLNSILSQKEKLQDQISNIIDKIRFIDYSKQELKDILKQNLIPKQISQKLIQFQKLQENENELKEFIQNEFQNENSFIFQSRIRFKSKIIKELIHFKKIKEWINDNEFFFKMQKGYSTKKDGINYEKWHDICDNQGKTLVIIKSNKNFIFGGFTSIGWISDESKWTNYTGNDREPEKFTIKQGKEKFALYYHPDCGPCFGKDDISLDHFLNNFSNFGLCYNLPNGIQYRSNEAKSYLAGSFDYWEVEELETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9M2</accession>
    <name>A0A9Q0L9M2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9M2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="81" mass="8681" checksum="D7F53CC74BAF762B" modified="2023-09-13" version="1">MEGLCHLVIVIIITSAFVVPSLVVAGKDKDLDFWATRDGVKDQCGKLYNVTLGDAIAILVSGVLFTILIICTVLNMGTMVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA11</accession>
    <name>A0A9Q0LA11_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein lol2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA11"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="800" mass="94112" checksum="1CD7A7929EBFCB04" modified="2023-09-13" version="1">MANLVQSKYGLQPRKLLQRVPKSRRSISFFAGPQQAEENKKEENIDKVRVTLNQFWNTGQKTRAYIPTRNENLRSQLANMEKLLAKREKDLLLAAEIGQTLLEKNLVLESTIEELQHDVEKEVQKRHEEEEYIKELSSQYQELSDQKRKTEFLLNKSQKEAQKLEQSLQQTQDQLNQMQETYQQMEKEKEKNIKFLQEQQHGEIIEAQEILLQKIENLTKKNRLLEENNQRLSKQETTIKKLRNQVDLLEDEKIKSQNEKEDADRQLRELQRKFKQLQEQTVDIDEFNKLSYELTLVDDRNNFLRMSNESLEARTKHDSEIIESQRTQIRELQDSLKRYKMGQHMTPKSKSIMDELREIRSEQKTKEKISPIVIREKNPTGQKKIKEQQNFPAPRLSSQMDKMTRTKIIPKKQNQRKIKNQNLQSKMESENKESPILENEFVVMDDPFKNSPTKSSMQSNNKESQESKSNPEIINSENNQTKQKTLEKSELTQLENTQTSENTKEISKTSAEKPKQEKMEAEKPIQPELIRDGNRISTNDPQNTTKNSEKLQPNDPKLLEKPEKIEDKEITEMDENEKPKQYEINRLKFNIPEEADSESSETEQNGMDDLEKIFNTIQGDKTNLFYFYKLINRVRRANMKYVNPSMKNADVEDYSTYYTKLIGECNRQLNQIIKDTEDFVQAIGLAKITSATPVDDQLHDNNSDCILASLIIDNCNHMIAVNLMSYQIHLPVFEKMEKFRKMWSSQSQKKEENQSKESTTESTKESTKESTKESTKESIKKPIKKPIKKPIKKSKMKYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA86</accession>
    <name>A0A9Q0LA86_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA86"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="57"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="235" mass="27908" checksum="89F53D48293619E2" modified="2023-09-13" version="1">MKQIEKKINHLQKEFKKLKGKEIEEIRNELNKLKEIYYEKAKEKLKNKQKKEKEDENVSNLLLKEDKDIKKIIDLMKKYPKNEKIQENGCFGLFQISETNEKLLNEVLKDEGIIEVIINSMNNFPNNPKIEEKSISILTKISKDLKNQNKIRKLNGIETIINIMNKFWDNEEIQEKGCWTLWNIVTSNFENKVKIRELNGIELIIKAMNKFPDNEKIQHGACGAFKTYCFFQQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAT7</accession>
    <name>A0A9Q0LAT7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_02206</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003000">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="911"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1108"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="15">
        <location>
            <begin position="1508"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="483"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5069636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1588" mass="185167" checksum="6BC1AD13FF1F0CA2" modified="2023-09-13" version="1">MNPNKIPNPKLTPNKNLIRSKSNIQPSLSLNNLLQSPLNSNPKLNPNLNSNLNPNLNSNSNSNLNSNSNSNLNLNSNPNLNSHSQPSLNPNENFKEIDFINAQKELFARKNLSDQIIRNENLGFSNQLKHSHSDKNKFKNFHPNQDYQELYFNSPNSRNIPPNLPFARKQPRKLLFPQFENQEESQIRIDQKRHKKDFDLENFFGNQQREQNSYKNPLFLNKKKLKKLSPGQLVNLKKNLQQHSLRISNYQYLIEKIMRKKITENSFLQSQLPFFLSQDNSMSQEPFMNGTNEMDEDFFIQQKQRKYQNQPFKKELINPQILHQEFIHNSQDHIVNNRNTFSQPLISQEIPHNSHTIDLNQNQNQNQNQNQKTIFTKNQQINTKTKTQPKTKENLNLNLNQNQNQNQNQNQNQFLNSSPNLKRKLTQPKIHSNQNTNQTSNTSSNQNTNQNTNQFLNQNTNQFLNQNTNQSSNQFRNQISNQFRNQSSNQSSNQSSNQSSNQSSNQSSNQSSKEIENQTIPIQDIEQDEINRKKNEYNYIFKRNTIEKDEEEKEDQNQNEDENKDQDENQDENQDQIQNIQQLIPKQPPKGKTPNLEEYAKTDFYFSSAVETVKKSIFRIESFRTNQLEVVNASLLKKDLFVLMPTGGGKCHAKNTKIMMFSGDYKMVQNIKVGDLLMGEDSSPRKVFTLCSGEETMYLIKPENGETFKVTESHLLSLKNQKNKTVDISVRNYIKKSHLWKNKYHLYRVPVVFSRTNLPALGLYPDFYQLAFNMGNLNHKFKGKNNIGKFRIPKQICCSSRKSQMEIIAGFIDSIGSVSNKGVDIDICLYFQKKDKIGEDIKFIIRSLGFEIIREKYAKKKEYKIHEIIFGGSEMEQVPVKLERNKGIRNTEYKLTTKFEIEKLGVEEYFGFEIDGNGRYLLHDFIVTHNSLCYQLPAILNKGVTIVISPLVSLIHDQVLVLKSLNVKVRSFSSDMTEPEADAIYKEIDSEKPDIKLLYVTPEKINRSWKFFEELKKWHKAKKIIRFVIDEAHCVSQWGHDFRPDYRELSILKKNFKDVPIIALTATATPPVIQDVIESLLIPECEIFKQSFNRKNLIFEVKMKREQNFEEIIYFIKKRYPKKSGIIYCFSRAESEILSKKLEERGINCSFYHAELKNRSEIHEKWRSGKIDVIVATIAFGMGINKPDVRFVIHNTIPKSLESYYQESGRAGRDGEPAHCILYYSEADVSKLLFVMNNEEPNENNGRNDENQPNFQAYNNNQKSYVVPFVKSEETKRRQNELLYYIIRYCENDYKCRRRIILKYFGEDFNSEECNGKCDNCRNRVKLHFEKINSTEDAKKIIEILQESGNMSKSKLLKFIAGEDFIIRNESVSERLHFGFGFIYSSVMIKKIIHKMESLNILGTKFLIIPKSFSAIPIYHLEPNHIKVLNGEMQVKIWIPKQYIKNQMLARRSNSDSVSFQKEASTKPKNVKRTFSNETNDDKIVLLDIRPENEEDALINNWLSQELDPKKVTLFCKLEDIRGVLAKDNNCSPSEVVSRVTLKNLAEICPSELSILEDFPDFDGFKIKRYGIHFVNEIREFLGMDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAV9</accession>
    <name>A0A9Q0LAV9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAV9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="163" mass="19930" checksum="60646CC7B69C4845" modified="2023-09-13" version="1">MIYSNRIINPKLYFEIKEIINLNEKIEETMKRIYLNENEKEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLIKKFNNQNQNEKIQQEKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAZ5</accession>
    <name>A0A9Q0LAZ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAZ5"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="226"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="327" mass="38100" checksum="EF2D74C48A3AB4CB" modified="2023-09-13" version="1">MSEIQKAIETHDIEKVRKLVSSSGINKPNDGNTLLHFASKGKNHEIILLLLKNEANPNIQNGNTPFHFACFWKCSEHIIYDFLSFGADIEIKNNKTPLDFIFDLKLKEEFKNFSSFGDEMIQLLERQESGDLKIITKDKTIFGHKIIFETRIGKQLIDQSLKIFEQYNSQEVIYFLKIIYGGRNQDIFTKNKEIADKIGIKNFTNLFGKNSIIQDYSKLYLDENSKDFTIITKDYNIKAHKIILMARSDLFRGMFLYVKDDSNQVHDYSQKSGKSIETLIKFLYSDHLDSNLDKSVYQELQDAHDFYQLSQFSLLPKLLLEMKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB22</accession>
    <name>A0A9Q0LB22_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB22"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="108" mass="13172" checksum="8BB5A4E918236596" modified="2023-09-13" version="1">MKKIFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIEELERGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBN3</accession>
    <name>A0A9Q0LBN3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBN3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="547"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="652"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="723"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="758"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="793"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1163"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1198"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1232" mass="140925" checksum="F4C2A217D57E2398" modified="2023-09-13" version="1">MELIYKTILENNIEYLEKIEKIEENKLKKENKLILHFAIEKKVSKEIIEKLISKGIKPELFDDLGRNSFHIAILNNSEKDILELLLSKGIDINSKTIKTRFLKAFENLSPRNIIYLHNKQINIDPKDLIKETNLNIPSQYQNSKIIGYLLQKQMNINPNNFLNKTSIHFACENPNINISDIEYLISKRIDINAKTNDNKTVLHYASQFNSLEIIEYLISKGIDITAKTINNETALYFACLNPNNSLQIIEYFISKGIDITAKTKDNETALHYACQNKNISLEIIKLLIEKGIDINAKTINNEIALHYACLNPNISLEIIKLLIEKGIDINAKTKMNETALHIACKNENISLEIIEYFISKGIDINSKTINNETALYFACQNENISIQIIEYLISKGINIHSEIFNNETALHIACQNSNISLEVIEYLISKGIDINEKKINNETALHYVCKNPNPNISLEIIEYFISKGIDINTKTINNETALHYACQNKNISFEIIEYLISKGIDINTKTDQIQTALHFACENPNISIQIIEYLVSKGIDINAKTINNETALHFSCKNKNISLEIIEYFISKGIDINAKTKNNETSLHIACLNPNISIEIIKLLIEKGININEKTYMNETALHYACQNENISLEIINLLIEKGIDINSKTNGNETALHIACQNENISLEIINLLIEKGIDTNAKASGNETALHYACQNENISLEIIKLLIEKGIDINSKTKYANKTALHYVCQNENISLEIIKLLIEKGIDINSKTNGNETDLHIACQNENISIEIIKLLIEKGININAKTKDNETALHIACKNENISIEIIEYLISKGIDINAKTKYGNETALSLSFKKERKDIIKLLLMNDVNIFRLKEDQITKQFIEIFNKIYSINEDMNKLLLDSNDNNNNFSDYQIQSKDGFKFKVHKLILKTRFDNNESILQKFINICSQKPKKEVQLALNFIYTGFFDLHQIYKKINGIDDHFGRKGIIKDLSKLYEENSTKDFTIIISNEKQIKVHKLILIIRSELFKGMFLNVQDSSNQKENKLILHFAIEKKVSKEIIEKLISKGIKPELFDDLGRNSFHIAILNNSEKDILELLLSKGIDINSKTTKTYFLSAFENLSIEENIIYLYNKQINIDPKDLIKETNLNIPSQYQNSKIIKYLLQKQMIINPENFLNKTSIHFACENPNISLQIIEYLISKGIDINAKTKENKTALHYASQFNSLEIIEYLISKGIDINAKTKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBN4</accession>
    <name>A0A9Q0LBN4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBN4"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="250"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="358"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="552"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="647" mass="76189" checksum="38EB37DFEC57E266" modified="2023-09-13" version="1">MYFDILANPLIDACQRNSLKDIKKLVSKGEDVNTENNYGETPLHILCRYEFEKKIKAVKFLISKNADINAKNKNDETILHYACRSYNPKLFKNIQFLISKNADINTKNKNEETPLHLLCKIENSFEIIQFLISKNADINAKNKNDETILHYACQSQNKNPFEIIQFLISKGADINAKNQNQETPLNLICKNENSFEIIDFLVSNGADINIKNNDNETILHYVCKYQRNNLFEIIKFFVSKGADVNAKNKNDETILHYTYQSHNPNLFEIIKFLISKNADINAKNQNEETILHYACRSYNPKLFEIIQFLILNGAEINFKNKEKETYLHLVCQNENPNSIEIVKLFISKEIDINSKNNNDETPLHYACKSRNPKLFEIIKFLVTNEADINAKNNNYETPLHFICKNKNKNSFKVIKFLVSKEVEINPKNKNDETPLDLIYLIIQSNDSFKFKVHKLILLTRFDNNELILQKFINNCYQKPKEEIEIILNFLYTGFSNFDKIIQLKNENENEEYKKITKFFKEIEIETNWIENKKGRKGIIKDLSKLYEQNETKDFTIICEEKEIKIHKLILIIRSELFKGMFQLNIQDSSNQVHDYSQKSFKTIQELIYFLYHDNFSKENISKEYFDLKDYYQLNPNSIIDLILKELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD58</accession>
    <name>A0A9Q0LD58_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD58"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="75" mass="8739" checksum="D6B8A71E1C09466E" modified="2023-09-13" version="1">MNGSNWIQQEILTASDGNAGDFWTFWFKFLLISQLLLGMMKQFYFSSDGQIVTILVKSVNLYIFILYCLVLLMQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDF9</accession>
    <name>A0A9Q0LDF9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDF9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="398"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="555"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="648" mass="77614" checksum="872BFAE1312BE9E9" modified="2023-09-13" version="1">MDNNNNNNQIENANQNENENEMKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFDKFLRGQNDIDKIFLKQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNLNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRVNSLKLRKYKHKMNAKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFLPNSFLVDIQNKVIQDNQKEIENKEKENQQMKIEIEDKNKEIEKNQKEIEKNQKEIEDKNKEIEKNQKEIEDKEKENQQMKIEIEEKWKKEVEDMKPIFDKYRDQYQKDLEYEKKMKEFGKAFSDSEIIKDIEYVKKLQEWINDNDFFSKMKKGFSANRDGFNSKKWHKKVDGKGKTLVIIKTKDNFIFGGFTQVGFNGNKGNINDSNAFIFSLRNDKGDRIPAKFTIKQGQEQNAIHSHLDHGPVFGSDGTDFRLSSNLQPGLSQFGSRYNLPNGITYNTNEAQNYIIERKEKQYKFPKLILIIRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIINEIKIGIDYFQLNQKSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE59</accession>
    <name>A0A9Q0LE59_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE59"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="590" mass="68776" checksum="FA0051FA0A047975" modified="2023-09-13" version="1">MNEIIFFGSNEAPKLIKNKPNEITKSIQFKFENENENENENEKQIKQISSSYYSTIFLFKNGKAIEYLNENDSNPEEIQIEENIQKVTVGFENEAILTIKGNVFAKGEDINPKNPKEFINISSLIEDTNDRIIQDVVSGYTSIYLLTSNQNAYGIGSNEYGQLGFDSETLYKTEKPILIMKNVSKIFSGNTSNHVFLLNSNQELFGCGNNLFGQLGLGESRKEYITKLTKIQNIPKGEIIDIQSGYYYSIMLIEDGNENPKRKLYSCGYYEDNGLGKDENTYEFTEIKSSLFENDDNNIDFSVGYAHTLILTSNSKLIGFGYNYYGQLGTGDTKYQRIPIQIKLPKLRFNENISNYHIYCGSYKSFLYYSPSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNEIEKLKEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDELETGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE78</accession>
    <name>A0A9Q0LE78_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE78"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="146" mass="17430" checksum="64C7B51ED2371CC0" modified="2023-09-13" version="1">MSNLKNDYFSSFKKLILWSDGGPHFKNKKLFFFFSEFSEELDILIEHNFLLPNHGASECDEMFGRLKQLETREKVKGNRPNNKQDYTNLIIEVKTFKGCRKFFQFYYTQTGSVQARHLSNEGNYELFPLEEIETPTRENQFKKFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEJ1</accession>
    <name>A0A9Q0LEJ1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEJ1"/>
    <dbReference type="OMA" id="FFAPTFC"/>
    <dbReference type="OrthoDB" id="6777587at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="302" mass="34936" checksum="A4F915ABAE8479C1" modified="2023-09-13" version="1">MEKPHINSRGWVYNFANQNDIIIKLPQVLERARSQVSVDEFFAPTFCYSPKIENFHTTLVVCVNAAGKSLDPLVIIPMQSIVIEETPEKELVPPFSFVHAPSGWITQEIFTKWAIEIFIPYVQLNKKTKEEKTLLILDGHNSRVSSEVIKDFMKNQIELFVLPAHSSHFLQPLDLSVFGTFKKYLRRRGKLSSNILSFLDVYDAFQSSATIKKIYSGFNKAGIYPFDPTKVLGNENIVLKPAGQEKLKKQRKRLDINGKILTSQEMLEKVEEYEKKKPKTKRKKRKKKNYKSKKTLFNKNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEU1</accession>
    <name>A0A9Q0LEU1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G1/s-specific cyclin-e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEU1"/>
    <dbReference type="OMA" id="LRICNEW"/>
    <dbReference type="OrthoDB" id="306099at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="210"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="690"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="929" mass="106422" checksum="7766CC88100ECEF2" modified="2023-09-13" version="1">MLSNLNPSSRKTSFFKRKIPKTEQKKRKSKNQKQIKRVLSMRLIHFKTNKPRIQLPKIRRKKIKQPHKIYIIIEEIYIQNKLNQIEFIDPKKFLNNSFSRESVFSENPLDPLMIPMLKDSRNLLPNSVLIDSNLDPIEIIQKNFQSFEFQKYNNNLLSQSSNLEFFNYSNQVLTENHLEMMFQKELCYKPNEYYLLNPEFSQQFRINFVEKISKFCWILNLHKKTFYYALNYFERLLNSIPKIVVNNLNLVITTCIFIASKIQEIDVPSINFFNQILSGNTNQDRKSEIKKMELFILKNLDYLLIPQTPYCFLKYFLNRARFLFPLDRQSVYRKMNQNINLAPEVSFVSEHFTILIKNLFNLEKNKNDNYDLVDDTNLNTNTNTKSNTNTNLNTNTKLNTNTNRNTKLNSNLNTNSNSNINSNINTNINTNINTNSNSKSNSNTNTNTNLNTNSNTNLNTNLNSKLNTNTNLNTNLNTNINSNSNSNSNSNPNTNTNTNLNTNINTNINSKSNSNTNLNPKSNTNSNTNPNSNSNINTNLNTNLNSNSNINSNTNSNTNLNTNSNTNTNSNLNTNTNTNLNTNSNTNSNTNLNTNLNTNSNTNLNTNLNLNSNTNTNTNLNSNSNPNTNSNSNTNTNTNTNTNSNTNTNSNLNTNSNTNINTNSNLNTNKNTNLKSNSILDSIFNSSLKIHQKRNPNSKSKINSNSKSNPILDSIFNSNSNSNSNTDSNSNSNPNSNTNSNLNTNINTNTNTNTNSKSNSRSIYDSLFNSNLKLKSKQKNKSNFLQKIQKIILEENNGNNENDISEIKSTTCFSMTRLFRLPKFAEKIYASLCETINISLFDEKSLHFLPSTIAASVLSQYFVRDSELKLITRYSFDDLRICNEWMFKYIKIPVNFQQENSIKGIDPFSRHIYNKNNNFDLLFGKDIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF51</accession>
    <name>A0A9Q0LF51_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF51"/>
    <dbReference type="OMA" id="IHESQDV"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="396" mass="47167" checksum="08C44856019A7221" modified="2023-09-13" version="1">MIPTQFIEPVKKISTPDLLNEWFKTDAYFYLTGFIRELNKSVIKKKNSDECFVSENVLKISKILDLMSQWVDQIPPSNQPRRFGNKSFRVWFQKLAKNAQLLIGEIIEEKVKKFSIEIAKYLIESVGNERRIDYGSGHELAFIAFLFSLFRIGFFTKEDFQAIIVKIFNQYLQLMRKVQIIYNLEPAGSHGVWGLDDFQFLPYLFGSAQLIEHESIKPTSIHDIKIVKEFHQEYLYLDAIKFILDVKTGPFFEHSPTLDSISAVKKWSKVNSGMFKMFQQEVLGKFPVIQHFYFGSLIPWEQNVFKERYLQEEKKEEKQHHQKDKKKKKKEENQNQNQNQNQENENQNQNQNQNQNQNQNQNQENQNQENQNQKEEEKKEEEKKEEEKKEEEKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFL1</accession>
    <name>A0A9Q0LFL1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5071987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFL1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040171877" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14617" checksum="CBB3D5B013D4E0E0" modified="2023-09-13" version="1">MKKFFFFFLISILFLILFVTSNKIIQKTYQDQQCGKHVMVAYFEVDRCYTNIDGSFKINSTTSTEFLEFSCTDKECQDCIFSSFSLEKCYLLNNISRKYESSAIKFSIRPLIYFFLITLFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGG5</accession>
    <name>A0A9Q0LGG5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acyl-aliphatic-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acyl-L-amino-acid amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_01411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGG5"/>
    <dbReference type="OMA" id="GTDAKQF"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000001">
        <property type="entry name" value="Aminoacylase-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010159">
        <property type="entry name" value="N-acyl_aa_amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01880">
        <property type="entry name" value="Ac-peptdase-euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="11">
        <location>
            <begin position="184"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="396" mass="45199" checksum="32C7CE565BACBEE0" modified="2023-09-13" version="1">MNSKDERVLNKFKQYLQIQTVHPNPNYEEAIKFLENYSKEFLLNFESFELVKDNPIGHIFIEGTEPNIPSILLNSHIDVVPADTNNWKFDPFSAKEEDNKIYARGTQDMKCVGIQHLESIGRLVESGFKFKRSIHITFVPGEEVGGHVGMEMLVKSGIIKKWNIGVAFDEGLANPSEKFTVFYGEKAPWWILFTAEGNVGHGSQFIENTAIQKIYSVMTKLTEFRNKQLEILKKDPNKTISDVHTLNITQIKAATPSEKSINVIPSKATLACDIRITPKKSMEEIQKLIDEICESCNVQYQFLQHTPINNLTDLESQWFKTFESSCKELGIEIEPQIFPAATDSRYLRQLGIPAIGFSPMNNTPILLHGNNEFLDRDIFLKGVHYFMKIFSDISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGL6</accession>
    <name>A0A9Q0LGL6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch-like protein 24 isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGL6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="117" mass="14347" checksum="279FD9FBE81D102B" modified="2023-09-13" version="1">MEKFYKNQNLNNFYDFTIYLENKNENNLKSIKCHKGILMNRSFFFFSLFKQNSEKRKIFLKEYDFEVVNSIINYIYSSKIIFTSQNYPQMLKLAINFKLDLLKIRIEKEIEKEIQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH12</accession>
    <name>A0A9Q0LH12_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prespore-specific transcriptional regulator rsfa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH12"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="109" mass="13166" checksum="5330948C899DD7FF" modified="2023-09-13" version="1">MKIPENKNHKNRKTKPQKQKKQPRICSNCVPIIEKLQKMEIYKEENKGLRKENDDLKEAMRGLKDKNEKLEKRIEELEKQKETVSKKGAPKKIVIHWKQEGRFIWEMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHG7</accession>
    <name>A0A9Q0LHG7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase ii subunit 5-mediating protein nnx3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHG7"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="167" mass="20075" checksum="A8C3E5EB19E92DE3" modified="2023-09-13" version="1">MNQQQNSQPLNYERLKLHTEAQINLSNKKIEELENLINKYKYIQDQIEILPNKTTHKTHVKFGSLAFFEGKIIHTNEFLVLLGDNYFVERSHTQTIEILQRQIQKMMEKKNNFEALIQDLQKKLSFINEMIQLKNDYGNFEILEFEENENENENNQNENENENENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI25</accession>
    <name>A0A9Q0LI25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rcc1-like g exchanging factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI25"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="402"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="507" mass="59226" checksum="4F6BA72FC3A58CCC" modified="2023-09-13" version="1">MKTKNKFSNQNPFEKSIQIEENIQKITAGGDNIAILTIEGNVFAKGIDINLKNPNEFINISSLIEDTNDRIIQDIVCSRNSIYLLTSNQNVYGIGSNEYGQLGFDSKTLKKTEKPILMMKNVSKIFSGNTSKHVFLLNSNQELFGCGYNFHSKLGLGKSRKEETRIQKLTQIQNIPKGKIIDIQYYRYNGLGNNRHIREFTEIKSFLFENDDNILDFSVGNTHTLILTSNSKLIGFGSNYYGQLGTGNTNSKLIPIQIELPKLRFNENISNYHIFCGYHRSFLYYSPLPFSNLEEDLIKLFQRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI96</accession>
    <name>A0A9Q0LI96_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein furry</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="MRADTMK"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1455"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="3">
        <location>
            <begin position="168"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="5">
        <location>
            <begin position="628"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="5">
        <location>
            <begin position="1385"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="4">
        <location>
            <begin position="1624"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1924"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2143"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2252"/>
            <end position="2344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1924"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1948"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1984"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2002"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2021"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2037"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2105"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2149"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2167"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2188"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2213"/>
            <end position="2224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2268"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2281"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2313"/>
            <end position="2327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2576" mass="300146" checksum="4C6CBCF778700A0C" modified="2023-09-13" version="1">MENGFQDIIVHKLFTQLILISEALIKKFEKSKSFNILCFPILENQEEFNSALRSISAISDCCFSSLISGLVDWREQILSKDVKVVSFQISRKSRKSLSSLRLSAKKSTRADPFELKIEQIQLFKQALFAFSFKKILESQKTINPESQKILSKVLLIISSSLISLDLELDKLEPTSLVYITNKIYLRDLYGEILEIISSQKIELISELFFPHIQDKHSNQQMWIRIMRFSSFNLQTQKEIYLSYNFLTEAFKISSKLKSSNLHFFFESISKMLEKISSIEFDPNLDLSKWQKKVQESFEKIFKQSKKLREQLFNLRLLVTLLACSEKNFFLQNYKSVTNLIEKMFQYKHGKAIAIECYSIFLQVFLGKYADSDQNKIISQIDSFISQLFFHKKKSNILLDPVILNLLSGIVGVISNWNLKFAIEKIVLDLVNLDSLESVSLGIRSLLVITNHFEDPKTQKITYIGKQNQGDLEQNFSKLKPIVEKYFTLYDRQVGNLITSSQDQKRPTDKELLSREKRKGLEILKQCIDVTPHVLPFPKKILQMLSKYTTHLKEDISTSAITTLKKIIVNYPQLRMNLILEFGNNILTIPEDYPKLISDLITKFSELITIWIDCAKEEHNSTKIDDIFQIESITIIFLCNTNYDIRKQSLEILRKIRVLNEMVSLPSEKDAEKVDDIDLLFQNQRVIDIFEESWNEVSSQVILDATKISSLVQLITRQQQNEQQKPPTIDEVIAEEEGTKWMFYLCKMVKILSRLYPEVVEFCFPKVLSKVYSFNMEVLTKINSNKLSKVFFETVQKWYRFSMLATSIAQIQPDLQTSTKNLFQHLVPFLKSKLENHNNGAILALSQVNVKAFSYFSQEIEPIIKEIVSQKEKEKISKHNSRLLTSITGILRVFTQLLDPDDFKKDPEISTTIYRYITQIKTYILSPMQNDNPDLAFLIYNFALLIYHYANLSIINEMDFPSNQRKELFLILYDYCGIENTSLLQKMEDRFSQFIKEKVKDMNEQQKYVGVFKLDQKSIEYMCLKSMCMLLSGSFFDQNDTSVDGLVFKWIFRLLQSRQYYIRVIGQTSIKNFLRYNTEYLLPRYIEQAFCSNSEVSSDAFTIALTEIIIRDNISIDIPVILNLILFKITSRNREVRRQITEMIRFFIPKIFENEKLEGFPCFVPSLGGVPETLMQTQIQLSRMLASKKPELAFDMFKEINTRYWLIDNQMRHQLLNLESVKYVKKSMMRYLVPWLNQIKYDKSEPRILVNFILILNSLLEITTKDFGQYSDIMEEVWGAIASNAVNANAIVDFLVGSGLENIFIFIFIFIFYLYLYLYLYLYLYSPKDNSYQKHQEIESDSQLKSNLEDKNSDKENNNEENLLINEYRSTDNIQTKIVEKSISFTTPTVVANTTPSNTKNIQLIKLKRREVSIILLSEMVSEAKTKYSRHLPLLLHVIFTNLDHKYIAVYQNCKLFLVNLLLSLVINGPYSLKSNQINQGIELIDQITSDEKPLFSRENIYSNEPFAKDQMELTNLIIQVVDLFRSFKPKIQEKWCHEAFKWSTKMNYYGEELSHSNLHICVRSHQIYRSLITNVTRKQINEVIDLLLATLSSKSLEKLMIFTLEIISTLQHIANRAESLSNYPSLFWASVALLQADHERVFTFVLILVENLLDIGIQNEDIPQKLKQTIPEKWDPPFSGIQPLILKGFNFSGTEDITFRILSKLTLFENDEIIEKGPSRLLKSLLGLLPWICKLMKTEEANQTYPVAYNLANLAEKFELEKISSILKDYSEGKYEDQNNLLQDLEEPITKEFFPTHKSFIFNFLLQAIVSCSDNYRREFFNIFNILFQNHKLSHEEIPGKIAHELASRLIELSNTSKSGPALQIIDIIVRNNKMKKITFQVDTKTQTLPEINLPQEQSFKSVRMIQKIKQRTSGEVHDIFALDKRKSREMNKTNEDPKITKGPSLASGLTSLPELNTHMNNMIDLGDSNGIDGYESDSKSESNSEDYDDGDYDLNNDFSEHSLSLLSDNESQISEEHEPTQSQNHKTSPQTQRQLPNKKHTKEPQKLRNKRNHRSVGFDAQEDQGIKNDTSLQNKKKTSVHEFSGHTIKLTPQQLKEIQENTEDMFKLSSDDETNKTEELSKSDHEVIDEDPVLIQRLRLSLQQNPLNDDDEDEDEDDDDDESTKTQELNDFNSGSIFESSDEDSTERDKNNENDKNNENDKNNENDENDENKENNENDKTDENIDLNINTDENIDLNINSDDNIDININLDSDSDNDNIKNEIKNQNENNNENVNSEKNIQDENKIDNENDNINIKKVKSNSENFDDNEFSDSKEFTSDLVDKNDGSNSIPKHGDNDDDDIQEDSLEEKQILERDDSFIENEDQFENDLQKIETEPISEIFNFYSKKMDTFHEAIINFEAFYLDSQENMKGKINQKIIKNEIFNIDIFSISNLKINVDSKKQKEYIELFEKDSPQEFEKMTKFFNDIQLSYFNIEKLFVQTMNYVDNLQKKMKKQGKLDEVVENKICSGLIELLELLIGFIEHLIQLKRHIGLISKEMFDLKDLKSKIDQRLEQVQKIRELVENQRHLLTFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIK5</accession>
    <name>A0A9Q0LIK5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIK5"/>
    <dbReference type="OMA" id="EINIYLF"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="560" mass="66899" checksum="AF9104DAC9CB30FB" modified="2023-09-13" version="1">MFEVDFTKDVKKKHKSWNTGILKINNRRVTLFNDEDEELERSWLKKTDDLEIGKNIYLLHYSKKKDKKTKEKNLQFLLKRNQMKIKMKMKMKMKMKIKNQKINQNQNENENQNKNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNEIILKSPLKNNIEELYEGFRPLSKFLFPTSYQCFHLPVNSKIERKIKIPQEFENFEEYKNIFISSLIEEINIKVLEIGMSFYSLIRKLKWVSEDENIVCCKHGPCVIKIVKKEGENQGRFFYSCRLPHKDPDCCDAFAWADRDITSKNKGIKIKKRKEIPNLDKSNYSSIFNLHLPELEKLFFSNQILFHSNCEIFKKIENVQEKKSKLFTKMIKKRNLAFKKRQKQFRRNQKRRKNNESEESDESEDEESDESEDEKKDTSFIKQTTGNQFFLKVKKQINGAEYTKDDLWVISNVQNFEPKQKDDFIFFAKSIFFGVGTSGLVTLEPIGDFPNLFEIEPNKKYKDIFAIKCFNASTEFSAINNIEIIKEENIPLLEFILKKYQNQENENENENENENENENENENNENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJB2</accession>
    <name>A0A9Q0LJB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJB2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="313"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="391"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="486"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="591" mass="68762" checksum="D95B3CB9D13A9269" modified="2023-09-13" version="1">MNEIIFFGQNEKPIIIENKPYKITKPIQFKFKNENENENENENEIKQISSGFFSTIFLFKNGKAIEYLREKDSNQNSSKIQIENIQKVTVGYQNEAILTKEGNVFAKGYNINSNNPKEFINISSLIEDKNDRIIQDIISGHGSIYLLTSNQNVYGIGSNYSGELAFDSKTLKKTEKPILMMKNVSKIFSGNSSQSVFLLNSNQELFICGDIYHGQFGLGESRKKTKIQNIPKGKIIDIKSGNWHSIMLIEIEIENQNPKRKLYSCGYRQRNGLGKYENTNEFTEIKSSLFENDNNILDFSVGSSHTLILTSKGKLIGFGDNNYGQLGTGDTMSRSVPIQIELPKLRFNENISNYHISCGYQNSFLYYSPFLSPFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNENQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFELFEYWIYSNQIKEEIQITQEIIDELEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK89</accession>
    <name>A0A9Q0LK89_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_00957</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK89"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16773">
        <property type="entry name" value="RING-HC_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="260"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="264"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5074328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1259" mass="149412" checksum="788A81A333338039" modified="2023-09-13" version="1">MDLQKPSAIYLLKRMGISTHRSRRAIKKLELEEFDLPMIMLYIQEKQLERTKRKQEEKKQQDENQEKENELKIIQGNQNNQQNDLENQIENRLEKKIKKKKKKIEDFWGNTESDEEIHDKIDDENENENENINEIEIENENENENEIELEDSSEKEEMNESTETPGNLEDDDLSFLAQPKTRKSKKFLTEKDIFKKQKKMIFQVSEVVQRSQDDCLLLLRAFNWNQEKLLIEYFKEPYTTCKKAGIKYEVNKKVSNQRIPNVICPICQESYEDDQSNLLALTCGHYFCKNCWKEYLTQRIKEAQVNAIPCPGYKCDEKVHEEFIKSIVDNQLFQKFQSFQAKSFVDENPFVKWCPAPGCDRVIQPSQLYLSMAKCECGHRFCVLCNDEPHGPANCEQVKEWKIKINEGVSDQQTEIWITQNTKPCPECKTLIEKNGGCNHMTCPKCKHEFCWVCLGNWAGHTSYYNCLAYGTKLLVSKNNQLKIQEIQNIKVGDFLIGDSKNFKNNRRLVTDIFHSKGKLYEISQSNEESYVVNESHLISLKLTSNPYLDFKFDQNKNKIYWQIVYFDKKTHDKMRINFDVDNFENQDLDLDLDLDLEMEYLWNEEVLPILSRNLSFKKIYDSYISNEYKKTQVMNCFFQIVTYLPKLIQTDQTAIFGDKIDISVHDYLFHKSKNWKSSHSGYQVGTYFASQKTSSNPYIYASQINSNSQNQIPDEFLFNSRNIQEDFLLGLIDSIGSIQNEEEVVFHLNKQNPLIFDIQLLAKILGIFSQSKFIENKNSSIEIKLSGEKIRKLANKKRENSNLDSFEQQLLQKIKIKEVKFKVTQENGKSFFASEKHLLDLKFENQNEVNYLVQFKNRNNNHIELKAFVSYQDAHDFWQFERDFTKNKKDLKELRILSEENCYFKLSIKNYLLLPTQTKNYLKIYQFKNRLENPYIKIREEEIYHFQVEKHNGIGEFYGITVDGNKRFLLRDFTVTHNCNRFEDAKKNETRLKKELEKDQESIRRFQHHFQRYKNHNTSLGFEKNFYNRVSQDIKKMRKKDPLYFRVLSILEALDALVDNRYALKYSYVFGFYCPTGNVQDLFLYTQTDLEKVTEELSHSVENLPKIETEHLRSLTKLAKSRRFAMLETLDEVDKNGNLFEDNVKKNSQISFGKSRWDNDLEELFPKNIPLKPSNENLFEEPKSKLQNPKSNFKESLQYRLNRIRDNHERRNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNSKPKSKSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKH6</accession>
    <name>A0A9Q0LKH6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKH6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="141"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="287" mass="33367" checksum="F2D97D0737437CCC" modified="2023-09-13" version="1">MGTTESKQEFLSQTYKPSNLTTKQYLSSISQKLRALALVDSSGNYLGFNSPFYTLFEFNSEQIAKMTLRNLLSFTLAEGLHTYEWEYQTLSLAPLPVFVWLHPVRLLDNVLFQVNIQYKYSSLDFEKIDEELVTSEISAFDIGRFCLEKAVQVTSSDIGYLVFVDEEERTATQFAYSTKTMEQCKLLKKPLVFDIDKGGIWSESIKRKECIIVNDYQNSPFKRGYPEGHIPIIRTMNLPIFENKKKTKIVLLVGMGNKPEDYNEQDAYNLYDVMFNMWTIFKKKFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKI3</accession>
    <name>A0A9Q0LKI3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKI3"/>
    <dbReference type="OMA" id="HWGARYN"/>
    <dbReference type="OrthoDB" id="8193571at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="572" mass="65501" checksum="524D0029FF7D3EE6" modified="2023-09-13" version="1">MNIWEIILENNIEKLKQIKNISKNQLKERKKGKTILHFAIKKKVSFEIIEYLISKGVDINSKTNKNETVLHFACQSNSKEVIEYLISKGVDINVKTKQNETMLHFACQSNSLEVIEYLISKGVDINSKTNKNETVLHFACQSNSKEIIEYLISKGLDINSKTKQNETVLHFACQSNSKEVIEYLISKGVDINSKTKQNETVLHYACQSNSKEIIEYLISKGVDINVKTEKNKTVLHYACQSNSKEIIEYLISKGVDINVKTKQNETALHFACQSNSIEVIEYLISKGLDINAKTKQNETVLHFACQSNSKEIIEYLISKGVDINAKTKQNKTILHFACQSNSKEIIEYLISKGVDINVKTKQNKTVLHYACQYNSKQNIKRNTMLHYYFYAISKGVDINSKTNKNETVLHFACQSNSKEVIEYLISKGVDINSKTKQNKTILHFAIKKKVSFEVIEYLISKGVDINAKTKQNETVLHYACQSNSVEIIEYLISKGLDINAKTKQNETVLHFACQSVLILIQKQNKMKQFYILLTKQNRMKQFYILLVNLIQEVIEYLISKGLDINSKKLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKT1</accession>
    <name>A0A9Q0LKT1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043366">
        <property type="entry name" value="HECTD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46435">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46435:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="2018"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="3605"/>
            <end position="3823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="908"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2511"/>
            <end position="2541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3010"/>
            <end position="3036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3215"/>
            <end position="3252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1685"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="3219"/>
            <end position="3230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3234"/>
            <end position="3246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3823" mass="447371" checksum="64AD10A0C0447DC7" modified="2023-09-13" version="1">MNLNENQNEIETSFNFKVLSICWQNIDASHFPGTSFLQELYTLSSKRKKFKKIFKLNQVLFIEKFPQSLEINGLETQEKEEEQKDKQQDSELWKWRGGNFNEFTQICFESRIPETKNWSDNTDVSTLKHILKHLLKHREFYSLKHQDRTIFSSFIEMNVSFLNIFQRNFFRSYSSDSQNLVYTCQQKNCYWRQQADLQQYNFSQQHSSHPALQTMFFQIVSNQWSGLERNNCEKLIQILDHLEKNLRKSSIAGNTQMSEQIFDSLINIIAQNHDNKALVQQAVRTLFSLTSISNDEKLIQPVLTTPDEVSKSKTNFSIAFPSVFFKDKIFNLKFFFRTINESGIKKHLYTEARDPYKTFHIQFPHSLKQNKREQFFGSVTSSEAFIYVQDLHSLLKIGNGNSGTKYGALYLSAPFPRSQETGWIVFVSNRLFFRSPNTSPSTLTVIDPNTLKILGWINQNGKGTILTEDNTDHLFAPEDEEIRSPIITDGKFIYMISQFSNTKISQTKLIISVFDPQNGMKFVRKIGLCRESRFNGVEKYIFPIDPKCSNCSFFTNGHFLSAIIKDYRRQNNGQMGNINRDTNPSQSVCTQLIFSLESGLQVDKTSFLDHEIISSEPTNFATCYDPFLNLVWCYFPESMTLYAFGNEGGTSTLSGKEKLDDYIKNSNTNTNNKKNSNENNILDNTYLQKIMNQESSTVQQAIDGLVYVLANMASDYMPTHPFEFCPMGAFEPVVPFVVDGISNSHTNLRHLLQLLQLGVDSQRVGIVLSCLILLKANFFFLSRKKFTRSTFSDTFNFRQKINQNALIAHQIGNLLHNLVVGYQGSYETLIVSQATQTLLCGNRKVLKSDEDWLLLLIYELNSNKPRLDIFMETLFIEMIQDTESFIQSTIISVLDSIREVGLKEDPNLNQDPNLNLNQNQNQNQNQNQNQDPNLNQNQNQNQNQNQNQNQIQIKYEISLDIIVKYLIAFIKNKHLQTISLLEKILKFLLSVPFSSAEILLGKLIPEILTFLITNLSNTLNTIIREDQTMTKKYSPFLLNTTMSNMLYSLPMQNQGFNQAAELWRDMNLIKNVVLTNEHENSLKSWFLEDPVSRTLSFLVLSLYTSASVNQSISLKFADTLLSPLENFANILDRINIIANLDTSHSQFELYTALNQIYNLLLAPKIYCKISETSHPYNPGVSFRQTFKIDGAHSLTLIFDERSSLLQGDYLDLLDPQHPNAKISERFYGTHQKWTQRRIIVPGDSVVFSFYSSSRHISQKNYKNPKQSMNNSPSFWGYRCHIIGNIEPSSSWKSISLFLEAITLNNNSNLDLTQNNLFPKTSFDKTRRKQQIKMSIRLEYQHRLTRSFEIITRLLQFIKYPFMKDELLNSYKQTLIRLGILGNNVDQSLKLTSQFTLQTREAFHVLLDKLVQIMQDPKENPFLRRISSHFLSLKFSLEDHEFLTTHKIIEKLEYIIGVSFTQFIQPEEMNTRKNELKNYFDYNIHRFRVDLLTYFEFCGYGILMDKPTPEFIKNRLRNHNSSFLVKMNLFEGKQIFMTKLQYSYYLAIYSKIETFLYSQKAHLYSAFLRFLYFVAHLSFAREIFGNIDIISLLIKILNQGNGISQILVLDIFRVLLPGFNPRSLINDLSVNASILSYLLYFVGSNSSFGSLNNFSIPDLLIDLSEINLKMPLFLRGDEERKSQNINENQNINLNQNINENENLNENENLNENENENKIENENKIENENENINQNINENINQNINENINQNINQNENINLNINQNINENINQNEIKNLNEIINQNINQNINENINENQNENENEIQNEIQIINQNENEIINQNINENINENQNINQNQNENEIQNEIQNEIQIQNQNENINENQNINQNQNLNINKNQNQNENQNINKNQNENINQNININENQNINKNENNENNENINENEIQNENQIQNQNLNKNQNQNQIQNQNLNQNQNLSQNQNLNQNQNQNEIQNEIQNEIQNIFYSPEKEIENYINSNLKNDMFGEFIPFDVSIMIKWATKLFQNKCNHQSLLFEENQLLSPFNFEDQIFDKVPSKWFSKTLQIKNKTTIRKYGNQYSSKITKKDIAWGNLYIPKQLKIFYFEVKIVEEKSVIIEPNQRNIIQFNNQDKFQNNILIGFSQIQNIQDINEFTFFSKTGNKNRRIFHKQHPRRWNINIHNIDQEYFDSINKSSYLNIDSSDFGEEYGQPFGIGDIIGCGYNSENGTIFFTKNGQNLGVGFRNVYGNLYPIIILEMDEIFIETNFGRQKFVYDFQKSLQRNSKDEANNILERGFFRSRVLAGETVILLRKLSQVCLWREAMIELFDDIFENAQKLYSDIENKEPFKQNNYKIFELGGALAVLGGYIEFLRVGCLAKIDIYKLNETRCTISKSTLKLKGVVIDYSPSHSLANILIQNDDTKENDIVEIFVDDIIPVEEIKPEPFYFLNDKRFQWISNIIDFKPDKKEQDSLSLLFLHYRTQAMIVIEKNFKFFIKQYKLLEKEEEEKKISYNNKKENTKENIKENTKENTKENTKENIKENTKENTKENIKENTKENIRLSCVSQSFGSCKNARIPKVFLAKMISIAIGNHVKTFPAIIKNMRLKEVELMKEMYINNFQEYGNSKYIQEYENTKNIIEKKNRKEFKTTSGKDLDRKEWKHNAIEQITNTELKPSKKYNTAPRFDSSLMKIRRSSLPKSKAQTRQNIWESFKVGDLVVFSPEIPMKFHKTSQSYWSSAMSKFVNKIGVIVEKSHTGLYVFVKFFNDECGLSHKWWVGKQDIIKQQSQSDWDIHLSNIANGNADGQHLVRIIDKMQNELLVCYARKIVFKYLKIFTLHSIHKHKNAENINKKCSYKSNIHIVDSKMLIELLEISISNNKFEKLFQKFLTVFAISKSKSIAKTAHNFSVVSVLAQWLKERMDYLSQKNQEKNQSIIVETQHPLASEKYNFTKQILLPQASSLLVSFANKTALISLIQTLHIYKDAQFQNEIARFSGIFNETYLFKGNCIYFQLEYEGMRFPKDEQQENNGVQGEDVRREDAEKEDMEERDSIYGINARVSGVRSRLPDSDAHQPCMEHVLSLLPWILRISTKLVVGLDFPLLDIIISLLSLLEKPKLTKFEQVVLMECFIASAKLASMAQYRRQAPWFLQVTKRLSIYIRKLEKRARAILANDLRRSNSNWGAHSRYFKKICDFLLQMRLNKMIHLDLPRRNPTTFLRDTVSGARKETRHLQSKKKKTHKVSHSTQFSFQSTITNSNPKDSKTARTRSNIRDCFFFFYPQELGNTKTIFKYYFEFVNAMSDFKKSRFFSDSFVSTAFIQSQTRPILYKFTNHPEFTTQISHPKADRVYLLFDYINNTSQRVFFEIRNSKTRKVFTQRFPRTPIKLELDNNLIFFSQELIPSKSSNFKFFVIPLKFFEENNTNEQEGIRKFLQNCKQELSEIWSEKRDKELVYLINQTMTATGCSFLFEINSQNINLKFDQLTEEFTNIPLEKKGRRFLLLRYFNECALKFMSLMDFSKNYFSHSIGNAAFDLLVELKKFIFYNTKFIHLDEILSRTECATPDKTLISFPGCDDPKKRSTFKNFLYTLKSIPNHLLRRNNKDLFLIQTPQSPVPVELQDFVDYICKEIYSMRLSLFTNTPNSQYLKHIRCKDQVIPNPSKNNRKHLKLFKLFGKLIGILIRTRIKLKIKFPSLFWRLLVFGTPSRRDINNIDQQFFLFLGELSLQELSQKQFDDIIQKKDYADFKFFTITGFDGTITELIPNGSSIQISKENRFDFIRLAEKFKLNESQNQIQKIIDGIRCIIPEIEFFRLFSWREMEYTVCGNEFQKSSNRLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL54</accession>
    <name>A0A9Q0LL54_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Dihydrolipoyl dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_01034</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL54"/>
    <dbReference type="OMA" id="CAQLGMK"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="215"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="319"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="203"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="63"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5074404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="437" mass="47838" checksum="F501A394A59EC4A0" modified="2023-09-13" version="1">MISLSKSAYKFPSFDFLRSLTTKTKDLVVIGGGPGGYVAAIKAAQLGMNVLCAEKRGALGGTCLQEGCIPSKTLLHTSHLFEESKKEFPKLGILVDNPRINIQKIMQEKNKVVSGLSKGIEMLFKKNKVEYLKGKASITKPGQVLIEKNETNEKEIIDAKNILIATGSDFIDFPWLKIDEKVVLSSRGALSLNRIPKKMIIIGGGVIGLELRVENNTAKLKVLPIKEKDSKVIDIEADSVLVSVGRKPVTEGLGLEKLGIKMNKRQVEINEKFETNIPGIYAIGDIVRGPMLAHKAEEEGIAAVSIMNGGNSHINYDIIPEVIYTTPEVAKIGKTEEQLKSSGIKYRKSKFPYIANSRARAMSQTDGFVKFLTDQDHKLLGAHVIGPNASEAITECSVAMQYGLTVKQLSHVCHPHPTLSEAILETAFAAYFKPIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL66</accession>
    <name>A0A9Q0LL66_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sesquipedalian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL66"/>
    <dbReference type="OMA" id="CEIISHF"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="38"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="154" mass="17955" checksum="570601C7D8C71BA8" modified="2023-09-13" version="1">MENKSNQNQNQNQDTISKEIEKWKSIFQKKPKLSSIKKPQKAGFLTKKGVGMFSNWKRRYFVAKGPFMYYFLSEKDDEKALGVIYLRNCTLLKNPNPSKQFEFSIDTIVSRKPGKKADSTRIYQLCSTSSLEKDSWCEIISHFARPKEDNLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLB4</accession>
    <name>A0A9Q0LLB4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nucleoside-diphosphate kinase</fullName>
            <ecNumber evidence="6">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M0811_01236</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15 16">Belongs to the NDK family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="6"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="RVKFGHD"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
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        <property type="term" value="P:GPI anchor biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
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    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040249590" description="nucleoside-diphosphate kinase" evidence="20">
        <location>
            <begin position="21"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="893"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="934"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1025"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1064"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1275"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="21">
        <location>
            <begin position="46"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1159"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1191"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="190"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00008142"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00012966"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022502"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5074605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1297" mass="151940" checksum="FEB26EF5F7AFCCD4" modified="2023-09-13" version="1">MNSKKFVFLSTLIACVSVSAYVIHKEKEEQKEEKEEEKKEEKNSINERTFIAIKPEGIQIKKIGAIISRFEAKGFKLISIKLIKPTKQQAEKHYLEYQSKPEYKNLVDYLCSSFIVAMIWEGKNVVESALKLIGDPDPLKSKPGTIRGDFGINIARNLIHGSLTKESAEKEISIWFKNNEIKISFWIKIIKKINSENKLENKLENQLENQLENKLENKLENQLENKFENQLENQNQFQNKNQNQNQFENQFQNQNQNQLKNQNQIFDKLIIILIDAFRSNFILDPKRSLLMPFWSSLINSNSSITMKAKCESPTVTLPRIKSITAGIIPNFLDIVHNFQAVEFLEDNIIKNFYEKNKKIIFYGDDTWIKLFPNYFTRKDDVSSFFVQDTTEVDWNVTRHLDEELKNKNTWDIMILHYLGLDHAGHISGANSNLLKKKQQEMDQIIQKIYTSFLKNSSQNSQNIYDENTLILIVSDHGMNDMGNHGGNSAQETSTIASFLSPSIFANGNGVSSPAQSISQLDISPTLSLMFDLGIPEKNMGKLILPVFKIYPPKIRLDFLRKNTQQLLNLAEKMNINFQSIDSKKMNHINNIFKQAQNEHLFPKNISASYQNAENLYLEALDILQDTLTQNSTQSDSYSMLSSILLLFLIIFNIFFTMMNFLVDPKFEIIIQATKGFNLKFFLFTSSLVLAQKYLICRVFFDSFLCVDSGKYGILYWIFIAYLVKTMSNLISPLIHFIKNEKKQEIKKIANSLKMEVFIFFFELFHICSLSSSSFVEEEHQTFYYISTTLILIFFLKNLFQNNFNFNFISFLPIIPLIFVRVFRIWNKSGDKWLNDPDISKWLSEYSSSKLSSFALIVLNISTILFVMIINLKGLTQFFNLLKQQKSKFSQQKIYISFILLLVISSFFSIIQFFIANFHNQSSNQKIYQIQFFSIWFNYLTVILFMIIFVGIYIYLVYYSKFFDPNLTLKIKVNLIQNIQSILVILLILIHKPQNSFLFVLFYLQQEVLILFHKKTNQSKQNYKEIMIIFYYLSRLAFFAFGNTNSLSSLDINGAYTGLIKYNQIIVGFLTFLITFSGPIFFCFSISMMILISKLNQNYLKLENDLKNENQIHLKNENQNYLKNENQIHLKNENQNDLKNENQNHLKNENQIQIQNQNQNQNQNQNQNQNQNQNQNQNQNQIQNQNHLKNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNHLENHLENHLENQLGNYSIFPFFLSEISSLTLMLFFIFIFILQNHLFIWTVFSPKIIYEVSNLTFYSITSLFLFLIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLD1</accession>
    <name>A0A9Q0LLD1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Centromere protein w</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLD1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="82" mass="9696" checksum="2C8E788BBB1891EA" modified="2023-09-13" version="1">METFKGQIPSLKIRQILKSYDLKILNEETPSKIDVLCLVEYLYFLKLLAKECEHDAQKNEEKKITKESVDSVFPKVMNRFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLY5</accession>
    <name>A0A9Q0LLY5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLY5"/>
    <dbReference type="OMA" id="EFPVDRY"/>
    <dbReference type="OrthoDB" id="252020at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="257" mass="30057" checksum="D0EAE514116195B6" modified="2023-09-13" version="1">MSHSTHSHEKSNSRSSTHSSRSRSHSRSYSKTRSYSDSRTRSSRSSPRSHRKSNEQKKKDPEQKPRMLHVRNLTRNVTVTHLEEIFGKYGVIENVNFIQHPVTQVPLGVAYLTFKTYEEALEAKIHMDQAQLDGNFLIISFFDENDKDKITSKKKRSDSRSPSPSYRRYNSNYRYSGSRKRPAKSDTWSINDRERSPRRRTYHRRNHSRSNSRSYSRSPSYSRNSYSKSRSVSNSKSYSKSYSRSPSKSVSKSPIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLY6</accession>
    <name>A0A9Q0LLY6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone-like Alba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLY6"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051958">
        <property type="entry name" value="Alba-like_NAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516:SF4">
        <property type="entry name" value="FI09323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13516">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="5">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="293" mass="35175" checksum="38978433FF7D29BD" modified="2023-09-13" version="1">MEKFSLQRKTNRTRPQPGEIRISPRSRKNWIFRLILRNLENRDKVEVRARGSAIHHALIITERVKQVIKDLHQIVEIGVTELKSTWIPREEGLDIVETTKRIEYIVIQLSKTAPKDTNIVGYQAPPGKIYSSQDISFPRKDTIRSNFSNKPNDQQRSRFSNQRRNPRSQMPFGNRRRPFNPQRGFRQPMMRRTGQMPFQSRNSRFQRPRNPRNFRNQFSQRTQPSRSRFPQSNRRPFNPQRQFNRPRDNSGRSFNRNRLPQTFPMMVAYPPFYPQFSPRRNQYFSGRRPPQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM88</accession>
    <name>A0A9Q0LM88_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM88"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="268"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="437"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="540" mass="63372" checksum="64251FDD9ADE3504" modified="2023-09-13" version="1">MNEIIIFGRNELPKLFKNEQKKITKPIQFKFENENENENENEKQIKQIFSGYSGTFFFFENGKLIQYLKYLDSNQNIQIIEIEIENIQKVFPGDNNAAILTKEGNVFAKGENIDRKHPNEFINISSLIEDINDRVIEDALCTSYSIYLLTSNQNVYGIGAAQYGQLGFDSETLRKTEKPILMMKNVSKIFSGSSSYHVFLLNSNQELFACGDNYHSKLGLGESRKEEKIKKLTKIQNIPKGKIIDIQSGYTFSIMLIENENQNENPKRKLYSCGYYQYNGLGKNQDTYEFTEIKSSLFENDNILDFSVGNAHTLILTSKKKLITFGNNEFEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLNQNQNENQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKKIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITKEIIDELETGIDYFQLNQTNPNLFDLLIKKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNE1</accession>
    <name>A0A9Q0LNE1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNE1"/>
    <dbReference type="OrthoDB" id="19382at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="23061" checksum="F9AC0379DC4D1D2E" modified="2023-09-13" version="1">MGINKIETYNGRISTPNLSKLLDYDVLFLYSDYNWKDNQAISQVTQKFVEHGGALVFAGAFALSIEHPLKDLVGNIINGFLPLAKERVIRHHNSSLGEFELNHPLMKQIKVFDGGRASFYVDTEEVFGGKVIARWKNGRPLVIEKKISPEFGQIVALNIFPISESAFGNGWIPDTDGDKLISNSVIYAANHSPHTFREFRKKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNT9</accession>
    <name>A0A9Q0LNT9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein fan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNT9"/>
    <dbReference type="OMA" id="QVYKRRY"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="173"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="273"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="646"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="730"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="776"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="871"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="562"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="929" mass="107209" checksum="67B258299BC5C1EB" modified="2023-09-13" version="1">MIRIGLKNRFSLLLLSESEHYFSDYSANYFPPKLKGYFSDQKKVLGRLIICSKSIMFDPENFRYPIIKLPFSKTIGMQTSGQSLFESGDCFKIVTTLVIEMKENNTIKPYTFNRFRGQHTFSLNYTSMSTFTSLVKQLYEIDSLTGAESKIKLRNLIQVQQEQILFDKTLIEEFSERIILESMGELVSPLVKTPGRILVTTQRIYFQPFIKIAGEINYKYNLDSIIRIEKRRHILQQIGLEIFMKDNNSVFFSFKNTSERDNIYDMLLNKTILKDLPRNIQKTMTMKWKHRLITNFEYLMYLNSLADRTINDITQYPVFPWVISDYSSETLELDNEKTFRDLSKPIGALNPERLAYFKQRYQEMPEPKFLYGTHYSTPGYVLYFLVRKMPECMLRLQNGKFDAPERMFHSIEETWNSVTTMQTDLKELIPEFFEGDGDFLYNLLGLDLGTRETTGIKLHDIVLPKWASSPKDFVRKNREALESEYVSQHLHEWIDLIFGFKQQGEEALKADNLFYYLTYEGAVDIEATTDLVKRESLEAQIREFGQTPKQLFSTPHVKRLSKQEAEKLSLNFELLIEEEEKKGQEILHLVNESNNENSNIPNENQDLENQNQNQNQNQIISEIPQEIAIKPEESHNLTNISCVMTIKPHREIVTKVCLSSDSNTLYSVSQDSTLKIYSLANKKQLRSVVLGDLTLSTCDLANNEKTVVVGSWDNSIYFYSSDYGRVSHNFTIHDDAISCLKVCGNQLLTGSWDATVKLWNLQSDFQGVERTPDADFIENESEVKCIDMDPVKGICVSGSSDGNINIWDLKSKIHTQTIYCHNDEITGIKLIHNGEWIVSCSKDGWFKVHEMNSTELLAVDTGDPLSCLDFDGLILITGNEKGTLQLWDLARGKEIKSFKNHHKSAINSVCLSKDKRTLITAAENICVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP70</accession>
    <name>A0A9Q0LP70_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_06856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP70"/>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="759" mass="88276" checksum="D872CAE8BFF28D45" modified="2023-09-13" version="1">MTTLRIVVVGSGGVGKSALSIQFVHSKFIELYEPTIEDSHRKQVELDGEMVVLEILDTAGQEEYAIIRDTHLRSGDGFLLVFGLDKMISFQEVTKLHDQIIKTKEFPNVPMVIAGNKVDLVEERKVKSKEAQELAKSFNCPYFETSAKTRQNVDEIFFELSRQILRFLGKNPKSGNSLLVKRKKKACNTTWFHLPIETQIKTLTFILEKLQPLIIVKIPRFKVEKFLRKQWIKIKAIKNFGEITNKTTKQKLFLFEKYIAILKKLLSKELIEFSLETFPIKIFNFFINLLLQPLETITGLNHLEGKVKKRLTELISPIMMPVIVEFLCKRFGIYSEVIENYFVCVSILFNYTQPLNSTNEKRPHCDWFVSQSRKSVPCLSKNKILPIAGFIQLISEFISITLFHENINKRNEALKILEKFQVILFNLSLSKKIHDVIAKDEVSKNAILDVIQKTFLLDIETMLVKNLKLIYNFGSSLWKSYISQQTPIISSMIFQLKIRQIEYAELCGKVIFNLNHQYCSEKRELIYFSVIDSKLIDVLLSIILSPNSHLDLKEFAAGFLLSLLDLSFYEVKSSILHVYSYKTFVDPKSFETQELVLDVIKESLRDLGLSEKDLKKILKEKKRKEVKKWIENFCFLLKQFDKIDKIDKIDKIDKIDKIDKIDKIDKIDKIDKIDKIDNQEIIDKIDEIDKIDKIDKIDEIETEDDNIIIDDIEDLGNIDDIENVKENIDDNIEDDIDDIDDIEITLKNEEKDDIDEIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPZ8</accession>
    <name>A0A9Q0LPZ8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPZ8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="9059" checksum="C517CF73C5DA2671" modified="2023-09-13" version="1">MLSLTIQSPLHFLCQNTSITIDMIRILINKGVNFNFQEVKKKRKKEIFNEFVNYLFWNVELLIRFFGLSDAYILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR40</accession>
    <name>A0A9Q0LR40_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deoxyribonuclease tatdn2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR40"/>
    <dbReference type="OMA" id="THCHLEY"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:DNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000005">
        <property type="entry name" value="TatD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="TatD/YcfH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00010">
        <property type="entry name" value="YchF/TatD family DNA exonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46363:SF1">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="287" mass="33669" checksum="3A4E1FB38E42821D" modified="2023-09-13" version="1">MEKIEQKETNQETNEKIIEKTIFPYIDTHCHLDMIFERVKLNYSKKSWTEIQQELKFEEGIQNAVAIACDPINFDTVFDIVSKYEPVYGAFGLHPHDSKKFNQDIENKLVEFMKNPKIKAWGEMGLDYHYNFSPKEDQINAFTKQLKKAIELQKPLVIHTREAEEDTLKIFKEFIPKEWKFHVHCYTSSLEFAENIMKEWPNAYFGFTGVITFKTAKNLLKVVEKVPLDRILSETDGPYMAPVPYRGKIAHPGMIPKIIDKIVSVKKIQKEKVYSTLVENAKNFYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSA7</accession>
    <name>A0A9Q0LSA7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G protein-coupled receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSA7"/>
    <dbReference type="OrthoDB" id="200667at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="423" mass="50641" checksum="D0E3A14EE07DEF4D" modified="2023-09-13" version="1">MRKFPRFCSKPTRKTTNKYIYPFSWIKFKISQIFTHGFSKQKRKTLYNNLINSYTTILSFIYLFISFKALQIFDCKKQTSGVYTFEGDPSLFCYEKWWKDLLPWAIVCLIVYVIGIPVIFIILFFVSSKKLDEKTFDLRFGLLCSRYTKRWFFWEIFIMIRKLFLIISQLFISFDSIFQSVICVIVLLCALVFQVNSKPFVSDRHNKLEFVLICFSEIILFSGMIFASNDLERTSGRGILATAIIAIIWISFSILIIMILYEIRHRVRVKKGKEIDEIKKSDSISSGQSILKFLDSKPSFLLLWNWILESSEHKNKLQKEFFQQIKDFYNSNQTYQQKLNIDEFWESFLTKWKDSFYPIIQLWFLQASIQEKIQFMRILSKIHFESFLYLKSNSTKKERRKTRRLSIQYFKQNLLFIPQTNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT84</accession>
    <name>A0A9Q0LT84_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT84"/>
    <dbReference type="OMA" id="YLLYECC"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="859"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="995" mass="116272" checksum="25008AF0A474CCE7" modified="2023-09-13" version="1">MNTNSRFPNWKNSYPFIRIQPYNSLNEIPKERAGHTSVIYQNKMYIYGGARFFEDSFNDFYSFDLYLKKWEIVNQIGDIPIGRRGHSAIVHLNRMWIFGGAISDEIYTNDFLSFSFETNTWEQVPYKGSILPRMLHKCFLINEKQLVIYGGIDLTGNFLFDLNIFDFESGILTELPPSPSQTDSLNSFLFDQKLFTFDQFFKTTFYFDFQNNQWKGPFNNKGIIPKGYFGNSLSVVDNFVIASCGCLHDFSSTSDIYLFNPKTFCWILISTPQILSPRYQHTSISYKHKTSNQTKVLIFGGCFDQTRCLNDLFELSLPIGDIPQERNSSSLVILEKNAYIFGGKYNSILFNDLFEYNIHQNQWKKIESVGDIPTPRFGASSVLDRNRNDHNNMIIFGGKETKEYSNSLYTLDLKNYQWKCLIQKSQIISPRIFAYSFIYLNEIYVVGGYNLEKDSNELSLFKFSTEMNEFIPIAIQFPEKTHFPIPFNKTPKVFDQGALYVIADELYIGNIDPKKKSLKMKKKSLRNANPPMINKQIQAAQRSRIKPNIGSVIQDSSFAVFVKESIVVFGGFSPNNLELPDEPIIIDVEKKVWKFLFNCNNQPKRISNYSCSNFDNSILYFGGNHSDNDSNSTNTVQILHLESPIQPIIQDFLSLYHNPVFSDFKINLETIDKKPMQLFFHSFIFKERCNFPEDFSSEKIINIIEKFNFEIVDFAMIFVYSSHFDTHKFNSFSFQMLVSLFQLSKQLNLDYISYRCEEKLTNYHLNINNCIDLVQLFDNEKSANSLNIAINFIHQHQEQLFSQMEKFEQLSQLHPHLITKIETGNQPITNSKAVLLQEEKPKIELIQHFQNIFHSSKSTDFTIIASSPIINNNDEKNNLQNENIDPNQNKHLIPVHKSILYSRSKFFHDLFLLNSAENLTVFEENNQISFEAIYHFFRYFYTESLDMNLNLQLLFEIQFLIEIYCPNDYYFKEKCSDFINTLLSNQFQKDQIFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTA1</accession>
    <name>A0A9Q0LTA1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rcc1-like g exchanging factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTA1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="490"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69523" checksum="8FDC7E3F3C3D72F7" modified="2023-09-13" version="1">MNEILFFGRNQYPTLIKNETETTIIKPIQFKFENENENENENENEKQIKQISTGYFGTTFLFKNGKAIEYLNENDSNQNPQKIQIEENIQKVTVGYENEAILTKEGNIFSKGYNINPKNPNKFINISSLIEDTNDRIIEDIVSGESSIYLLTSNKNVYGIGSNEYGQLGFDSKTLPKTEKPILIMKNVSKIFSGNISVHVFLLNSNQELFGCGYNGYGQLGLGESRKEEKIQKLTKIQNIPKGEIIDIQCGVIYSIMLIENQNQNQNPKRKLYSCGFANFNGLGKNEDTYEFTEIKSSLFENDDNIIDFSCGNAHSLILTSKEKLFGFGLNNLCQLGTGNINNQSIPIQIEIPKLRFNEDISNYHISCGYDSSFLYYSPFSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLKEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKYFIIERKEKQYKFHKLILIMRSELYRGMFLYVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIDELKIGIDYFQLNQTNPNLIDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTE5</accession>
    <name>A0A9Q0LTE5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bridging integrator 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTE5"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003005">
        <property type="entry name" value="Amphiphysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514:SF3">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="15"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="275" mass="32504" checksum="B8605A128A47F7E4" modified="2023-09-13" version="1">MSKLRDSFLRQKENILQKIGKSKQTKDEEFEQISSEFNNHEIEMKRLFNSAQQFFQALKTLENTAKTLSNEIEGFYSNSKITNQTIPSKIAGNFSAIMDSIEELNNEHMEVIRPINSQIKYIEETKQKFQVRKKNQLQLDVLKKKMEKIEEKKEKKPEAISEIENKLQKAELDFVQINDDCKQNIRKIFQNKHEAMNIPLISLLRGQEAMLSSFKSTPFTPFYFAKSQQNQNQNQNQNQNQNQNQNQNQNQNYLLTEKPKNFDKEIEDEKKNNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTK8</accession>
    <name>A0A9Q0LTK8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_05769</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTK8"/>
    <dbReference type="OMA" id="YLFKHTH"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="173"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5077670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="338" mass="38532" checksum="C6C96102F781C7B9" modified="2023-09-13" version="1">MSHSSGIGASKELVQSFGQARNERIKRVIKIRIENMELAEVGNRDIENDEESDFALIHEEIKDNKACYILYRLDTVNKTFGDEWVFVVFVPSGSTVKDRMLYASTRDSCKKSLGGGYFMTEIYATEPNDISWDSILERRSNETYESLPYTDAELQQKEERLAEVVDSKTRSYVHSVAFPISSDSSENLKKLLNKSINFVQLQVDTSQETIELLDAGDVSLNDLPNKVNDAHPSYIFFRFKHQNKGKSEDPIIFFFWCPDTAKVKEKMLYSTVKSASLNQAGDVGVVTKKNIEIRDLEDFNESFFIAELYPPEKTVVKEKKFQKPARAGKGKARLVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU48</accession>
    <name>A0A9Q0LU48_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_04705</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU48"/>
    <dbReference type="OMA" id="GSCEERP"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="144"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="322"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="9">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="565"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="565"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="653"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5078982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="676" mass="79036" checksum="6F0A7539CAF1963E" modified="2023-09-13" version="1">MSTQNQSDRQFIRKNQNQNDRQFSRTNQNQGDRQFNRQNQSDRQFSRTNQNQNQNQNQNHGQFNRQNQNKNVMQFNRQNENDEYSIGKKDYKLNTGEIEVFELDKKQIYNYVKNFEEMGVPKNLTEILHQMGIEKPSKIQGVSIPYILDGRNVIGQSQSGTGKTISFCIGILDKCSPEKHFPQAICVAPTRELARQISEILTIFATEMNLKVFNGIKGIKYQEMGNINQQIIVGTPGTILFLIKNKINSQNIRICVLDEADIMFDKQGHLKEIQQIRKYLSRETQILLFSATYREDIKEFVQNSISNPVQIFLKIEDITLDSIKQYYIHCGNEEMKQKALLDMYDLLNLEQSVIFVNRRYTAKQLSQIMRDEGHSVSVIFGSEMTLFERDQVTDEFRKGERKILITTDVFSRGIDITTVSIVVNYDIPINANREANPETYIHRIGRSGRFGRTGIAINIIGDDTSLEHLQKICRYFNIEIEQLEKPEDLEKLKQIITAHDTKLLDTKSQRETEQKEVKNIDNLDNLINAMDSNQNQNQNQNQIEDQNQNQNEIQNQNQIQIQNQNQNSNQNERQFQKPNQNQNQNQKPNQNDRQFNRQNQNEKPNQNDRQFNRTNQNQNQIQIQNQIQIQNQIQIQIQNQIQNQLKSKPKLNLKLESKSESESESESKSESESESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUA0</accession>
    <name>A0A9Q0LUA0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nedd8-conjugating enzyme ubc12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUA0"/>
    <dbReference type="OMA" id="ANEFRND"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="172" mass="20540" checksum="4905B3F7D8A56021" modified="2023-09-13" version="1">MQQLFNAKQKINEETEEEKKFRLLFPRIIRDLAEIEFDDINKLEFPKDEKFAVGFKYIITPTKGIYRNGSFVFDIKIPKDYPHSPPKVICETKIFHTDIDERGEICYGILHDQWSVVYNLFQITMLLNLLFEEQHPDDPLNREAAELLKRDKDQFEQKVQEMINENSNQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUQ1</accession>
    <name>A0A9Q0LUQ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUQ1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="764" mass="93251" checksum="44D222D692284823" modified="2023-09-13" version="1">MNLNNLNTSLKEEEEDFLNNFFYRIVYQIWKNKTEKIEEIKEIQKFFKKCLDLIFFKIEEQNEEISKTLLLIFNFEKNCFYDYFPINYETGIKTYENGNFLSFWKQNPEELYNKPFENIFKIEKRRIIKENIEKFKFIENEELKDYPILLKENIEYFLRIRGFEKIICFLLSNLSTNLFEITEFIDRNYLDLITKISKIFSNEFLNLISSFIQFIIFKFIEFFGKLEKLDSNEGLILELLKIIERAEKENKKYLNFEIFIQKKIAINFSESKNTSLQFKSLEKLQQIISKIENEKFDKLSNNNLYGFEEIFINDFPSEKIMKIIFGEEIQKEINQISKKIILFLRSLENSNKKQIENEIEKKIKNQIDILFFEIAFKFQEKQKQKEIFLNWIKNFRINYEKNGIEIDYFFKALNSNPKNELIKLTFEYWKQILKRIIEIENENENENEIENEIENEMEIENEMEIENEKFFEECIDDCLNNFQKNYNYNKTNFTEIYYKEFIQKCISEMKKEKEKEKEKIIFRNVIELTKFIKFIEKDLKFKVKLIILEQNPKIYYLNENEIEIEIEISNQENVYSLIKKIEEKIQKKETEYQIKSHPQINKSNYQKLIEKEKTPSYILIEYFELLFNLLEKEENQEKYIQKSIIELISKIPLNPKYLENISNLLKGNFTKEEIRKEFGKINSFQYLYKLKILTKIIEEIKMKIMKLENINEEFIIFLIEEIINISTINQEEIKNKKILEYQLLLLNNLNELVIDKNKSKINSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUV0</accession>
    <name>A0A9Q0LUV0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000032">
        <property type="protein sequence ID" value="KAJ5079473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUV0"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927:SF1">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="330" mass="38029" checksum="7E07112FFC664A4F" modified="2023-09-13" version="1">MDYPNTAKSSQRLSNLFGMSDQAKKTGNENISFTYQKKIRKPKYDEYGETIASIISSLNYKNFFILIYSPNQPPVSRISIQPSISYTIQKEVFLALVDDNRQNISMKFQNQTDLIQFVSQLALIQILINSDIYKKDDVSIFDLSKGEGDPILTGTQIQVSYSGWLIDSSIQYKIGPKFDSSFDKKKPFRFELGSQKIIKGWNIGIPKMLKGGKRILLIPPSLAYGNNTVDKIPPNSTLLFYISIDKIKIADKQTNESTETKEKQEEKEETKDKQEEKEETKDKQEEKEKKESNENENKNENENKNENKNKNKNKNQNQNQNQESDDESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVR7</accession>
    <name>A0A9Q0LVR7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000023">
        <property type="protein sequence ID" value="KAJ5079630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVR7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="235" mass="28682" checksum="8E10D11F6222DCB3" modified="2023-09-13" version="1">MKQLFSWPWYGRFFQEYSLIVDKAYYDLQNEIQIVIPFKKPRGCELNQEEHFFNVRLSSLWIQIEHYYGRLKVLWSCMSNNWCGEREYFYQKVFGNNNEINNEINNENNNENDNENKNKPKKVRNKSKKKKSNQKEMKIKKKKKKERKKKEKKKEKKKKNKKRETNEKEKKTKIIKSNNRRRNLRKNPEKTWKYQLSKISESDSESETKSWEKESEYDTDYAPDSSSLESSIESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW67</accession>
    <name>A0A9Q0LW67_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ring/u-box superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW67"/>
    <dbReference type="OMA" id="QMFEIFA"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858">
        <property type="entry name" value="OS05G0521000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="215" mass="25366" checksum="6B5D2F78FF69BDF4" modified="2023-09-13" version="1">MNRKQNKTPTKSKTKEHFQLYVLGPHRNFHKKLNKLENSNENLRHFLINSSPKLDSQQFIDLNYGFYKINENSNQNSNQNSIQNLNQNLNENSNQNSIQKINENLNENSIQNLNQNLNENLNQKINENLNENSIQNLNQNLNQNLNEKSKSLENEDLLSKDDLCRICFVNKRSCAFIPCGHYYTCEQCALNEIQKEERKCPFCNTRIDKLLRIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWW6</accession>
    <name>A0A9Q0LWW6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWW6"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042496">
        <property type="entry name" value="CGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15379">
        <property type="entry name" value="CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15379:SF2">
        <property type="entry name" value="CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="351" mass="42116" checksum="0BB7F6526A3FCE96" modified="2023-09-13" version="1">MKKTKKQMENMKEKKQRKNQKVSKNTNNSSKKYSLLKEDQQDIIDNETKSGTEKQKEIELEIEMNSLSEVEEKPKENKKKKKKKKNKNILLNPEDVYICSDVKVFPQNSKEMQYSSEIFPFSLFEPNFQFKYQQQLSKYYPLVIIIKPKKSEKWTSKFPQFENTIHSKNRLQMYKENQFEEKEKLLENDERNSLTGYEIEEEIKTGRYLEKERSEILLENDDDYDDYNYNGMNYSKEKEKKGIEEIEFFIRNHIDQVKFINFKIIIIHFPKESLNPVVLHNLVVIDENIYSVDEVYGNNDFDSNECVVCMERKRNVILLPCRHMFICNLCLKNIDRCPVCRAQFSSHFVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX40</accession>
    <name>A0A9Q0LX40_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX40"/>
    <dbReference type="OMA" id="FMIIRIN"/>
    <dbReference type="OrthoDB" id="6142220at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="55"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="324"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="502" mass="58512" checksum="CD44C110B682585D" modified="2023-09-13" version="1">MNENTNENTNENTNENNNQTIQKSNQIFFIPTKKQMKSKLIEDFGEILKTSSNYSDFQIKVANDSITFNTHKSILSSRSPFFSKWFKENESSEIQFSDVNEQTMKNILEYIYTSKINSDEQNLVSTWILSNKFQLDLLTNFLENQILQSINNENVMNFIELNKIPKSNKLEKKCLNFISNHLDKFTSNENLTKLNQKQIERIISKRITNKEIVEVQIFEFIKNWSEKQIQSNENEIKKQNQIKQITKPIISKINTNLIRIEDIESLQQYNFLPNKLILNSKLSDIQEMKQQLEQEKLQQIEIDSSQNEKKKKKEEFYKKRFEESILATNEQYKNTIKTWINDDEFFNSMKLGFSAKKDGFSSWVFHSKCDDKGKTLVIIKTTSNYIFGGFTQVGWLSTANGNYINDPKAFIFTLKNPANQQPQKFTYKNNGQAIYSNNSYGPTFGGGHDIHVNQNFNQGSYTNLGHGYNPPSGYSYGSTQAQSYLAGNYNSWQIEEVECYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX76</accession>
    <name>A0A9Q0LX76_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sentrin/sumo-specific protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_04688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX76"/>
    <dbReference type="OrthoDB" id="7903616at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="10">
        <location>
            <begin position="573"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="408"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5078965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="826" mass="98084" checksum="C4A65EF4C1FECBD9" modified="2023-09-13" version="1">MNNNSKSKNTTIKVSKNTVDQLKQLKNTLTYDELIQEMIEVYRFFLYQKDTLNKSKIISSQNSNSPISSQSSSQNSQFQSQIVKNLLYRDVWEEIKNDPKSLLSFTGEKRQTIEFLINGIQTAFPNKQNSSPPNSPSRNEKLVDLPNRLLILLTWIKHYCSYSFLAVIWRIGTTTVKRYIEEVLTQLKTILENQIQFPPREELIRLEAEWNQVGLPSVIGVIDGTDFPRSRILKDEKAWYSMKRGTSCMKAIVVCDRKGVIIFFAVGFEGSMHDSPAVYACDLDKKLKPYKVLGDKAFHHSYSITPFKKRKKGFTKEQKDRNDLINKERSIIENVFSILKVKRILREKVRLNLHLHKAVILVCAALYNLSAKGRTLRKTTRNEKETKIYEKKQENKKVIKEIKRAQKEEKLKKEEEKNKSKMENKQQRKRRKTTKKGKLNEEKKINIIQNDEKKASCDRNNSNSEPISKKKDKQKHKSKDKSKDKSKHKSKHKSKHKSKDKSKHKSKHKSKHKSKHKSKHKSKHKSKHKSKQTEKEKKESEKNERNIQEEIGKQQNMQQNLDLIYNLENIDQIIETLRINESLDPGRFTTWRDRILSWIPTKNWFSTSDIDNFFQILYCYKRPQHLFIFDSGNLEMIRSQIIQNSELLAIKNEWIIPLFYQHHWILAVFHRNKNELEIFNSKPHQIYSRGINQLNSLLKAKLKVIKWKQKELQKNSNDCGPFICLFGFLRCFLRWECPQIVNFIQKKHGRKTRYMLAFLLEREEVQTIHFRIRRLYQQIQFLKNKLEEKGKEDPNLRAILNTISLKFREIFFWESFPFHNFVEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXV5</accession>
    <name>A0A9Q0LXV5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAPVD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXV5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="7">
        <location>
            <begin position="161"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="8">
        <location>
            <begin position="759"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5079295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="107554" checksum="3CD1E3048C801E97" modified="2023-09-13" version="1">MEKINQTLSSIQQQLKTQKICLEKEEKDMKEIRNKYNNLSENFMSTLVEGFNSISLMHKIKPETIVNQVEDIESWKVIKFGFLQSPLTFIQLHEYQKLYKLIRDSPKILAIAIMETPNLSEQDIQTLVYSAIPSIFSHFANEYEEKLFLIFVNECLKIRFVNYKEEKIHKILTTHQFLFQLLLMYCQNSHSYKYLISALKEPILDVIQTTNLKFTLVNLKDDNSQNDMITKKIVWFCKFFIVELKEKLKLLPQGIRWIASRILKISQKFKIRSHSIIRSFVFYIFLKPFILFPGKNLQELSKGFRKHNASKIFGENELNSFLDIFAQANPTFSSRMKEVKKGKQMIDPKYRITTALSTLSEIYKIHEILFNFAMKTKQKNFSQYPKIRENSIIKYVLRIGKPDFLIQEKDRKKYILLTRKEKKTQSINEVSSNEKQARNPRINLEKRSENIFQNANINIFDNPDIKPEISRKNYNLFEEDETQSKNIFNLEESSNDILFDDIEHKTPIKYPSFKQRVDSGIFSNLHDVFSINKYPLNESDSMNSNVPFVNLTETEKKLKLTLASMDDIRPEDGNNLIEILKAKRQLAQLSELLNLSCLIDTTLPLLKSLPKSVRKQNFVSLIKNIEMDATSEFDLKKILEKKYRYTELATKYEELIQEMSYKQNLYNQYVCCVISQHFFTKNWVKLKSFKDHLYNCSTFKQLNGGIVKFFQSIQDLILSDKMCTSFQGEDYKITSLVENYLLCHVYDEFFYPKFQSQLEKKDSDFSLKMTQIRRLVSPAFLQIPDDLWDESVWVLPILELSKVIRFKPPLSKAKVFCKSAQYIKSILFFRGREDAGADLVLPIIIYLIIISNPPNFPSNMKFIELFLDHKLLDHTQEYWFTISQSAFSYLNNLQLKTVQEFVSNFEEENQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R414</accession>
    <name>A0A9Q0R414_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_03585</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R414"/>
    <dbReference type="OMA" id="VKEYAGW"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="17">
        <location>
            <begin position="65"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="359"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5066252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="415" mass="49356" checksum="314C23760B5FB8D3" modified="2023-09-13" version="1">MKLDVRMFRYLSKESFRVLAAVELGMRNHELVPLPLIESLSKLKRGGSRKLIKNPCLKHKLVTHSSKDYDGYKLTYLGYDFLALNAFVNRRTVVSVGRKIGVGKESDIYLVRGRMDIQEDKTKDKKKQREEYEQNELLNEENKEEDVVPLILKLHRLGRISFQKVKLKRDYLKNRNSSSWIYLSRLSALKEYSYMKLLYERGFPVPRPVDVNRHSIVMELVNGYPLNQVKNIQHPHIVFHKMKELMIEIFNIGLIHCDFNEFNVMIDDKEDITLIDFPQMVSIHHPNAEVLFDRDVKNLLDFFNRRFKFIPDDEDVKGFCYKDLIKNYSENNVDLSNEIRQTGFTEEMEKELMENIDLDEKYDENEIENENENENQIENENEIENENENENENENENENENENENENENENENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4S9</accession>
    <name>A0A9Q0R4S9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitogen-activated protein kinase kinase kinase mom-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4S9"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="357" mass="41194" checksum="8F181D720AFED7E0" modified="2023-09-13" version="1">MVDAEQLAFNQQIEKVVKIKGKKTQTNKSNLNETQEKIFTGKRFFGSFYGFFIHFSENDKMQFATVRKLLSARKSSRFDRKIPTVSQATELFHSEIGTLVLSIKTQNIMLTTKPSKYKIVDIFSKPQEPYIKLFHGSLHSFLGNGSDLYSFGILTWELVTFQLPFSNVNDPNGSKYTIDQMSKIYQNYIYKYPYIFGSVITSIISQSVNAGAVSGMSVILQILAYGESQLMSSQNTNQNQNENENEKFENLKLPEIIQKNDSPLIFITKELIHKLERLKNIPDCLKQVEFVLKEFFFKSFFCFSTKIEREEDHIFLSVQTILETLGWSPLLSRFDESINEIEVENLIEVFQSLIEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R594</accession>
    <name>A0A9Q0R594_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5067018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R594"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="477"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="578" mass="67660" checksum="8BCBDF3678FFD1A2" modified="2023-09-13" version="1">MDQTNSKKLFIFCEQNSLENIQKLISQRIDINITNFEGETPLHIICQNINENSLQIIKLLIENGAGINVKNKHQETPLHLICQISNQSQYSVEIIQYLVSEKGADINVKTGYTQENPLHLICRNENPNENSVEIIKYLVSKRADINSKTGNKQQTPLHLVCQNQNRNEYSIEIIKYLVSNGTGVNIKDKNQETALHLICKNEYQNRNQNSFEIIKYLVSNGANINLKSKLYNETPLHLICKNHNQNQNENSFEIVKFLVLNGANLNTRTSYYQTPLSLAIQNQNQKVIRILLLNGANLFHSNINLFPKEFIDLLIQIYSINQDLINLLKSNDNFSDLEIQSIDSFKFQVHRLILLTRFDNNQTNLQKFINICKRKSKEDVEIALNFIYTGFPDFEIFNQQIEFLKKITDSFYSKTKKEQQLISTKKEDLKKKERSSENKLKEFFKEIGFDSNWIESKKGRKGILEDLHKLYEENQNKDFTIIISEEKEIKVHKLILILRSEVYKGMFLSVNDSSNQVHDYSKKSNETIQQLIYFLYHDEEKEINSKINSKMIEEFEDLKDYYQLNENSIIDLFLKDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R618</accession>
    <name>A0A9Q0R618_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008533">
        <property type="entry name" value="DUF815"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05673">
        <property type="entry name" value="DUF815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="1161"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="1516"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1988"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1997"/>
            <end position="2015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2236" mass="265819" checksum="4A7531869C1CB7A2" modified="2023-09-13" version="1">MLETQKLFDKFRKSKNLNLASKIQISFLVKYNTNSNNELVKPNEWKHIIKQKGKILGFEKWYKSLLLFMNFKKDHPNETNSQEQLSDFEKEFTGKLNQYYKGIKKFSRGIQSEKKASLEEVEFYLSNKDIFTDFIYLLPNSENIIQNITKFEDLKKQLPVNSQKFFHEFKYGQIENFTNLHKFNQKIIKIKEFGQFIKEIKNDDILYHIQKYDNHFYKVILRKTVNNIENCTMDLKNICKQTKENWFEWQAHISNDAIRINELDQELPLQYEKEFIDNLQDLDNINEKSMKKIKKFFEFRKQIMINNSFLLFCKFFLSEDQQKKEAEEFQKIGDEIEKLKKCKLHEIKKKFKTISKQIGLKKEEILNQNVSQYLIFLIKEIFEKGCKLTFDLKEPIFKCEIKDTQEIKTYYDFRNMWKVSLDQDKQNTSENTNENTNEKRDVLIHAHFKQFIHLYNLIDSIYQKIIRFIPIRYFKFIKQINKPIEIKPDNIDYDAELTQFEEDLSQILDDWIKNSQEISKHLLSGLFSETQYLFFFGSLIKDNDEKDLDKQKHIELALRLIFGYERKDQVQNVLKTLFEKSLSEWVTTSQVVFQEMQPIFNLESIQKEAFIDIGENLLLEDESDLRTTFINKLKKEGKYIYILKVPNESPVLSYATLAFYLFSSSFPLREQILFCTPNTTKKDIEAFFLVHYHYNSKHSDKKSTIQVNPFFAIINPNLLSQECQEIISTKKSPQKKKYKQIHVFYSSSPGNGKTYQIRKFCDKKQQESDEYHLIQLKIGDVTELVEELNNIDDKSANDQNKRFIHIEFPNECSVEITYALWQLSMWGSIENKKIERWNHFCWNLPENTTLLFEIPSTENLWQFFYPLKEFNFHECSFSEEKFSFDYYEFSEDLYKIYKKSDDDLRKVANFLIELDKKSLFESQDHLSHLKDKLNEIRQDLSIRDFVQISETKFKQILEKLDSSNNSQIPFTFELFSHFWKSLKAFINPIINWDIFTSDEQFRGRETYQEFETFLNCWVISVARSSIIPFLSKNLQNFDKFETTSLNIKFEENIPKMVSDESDSMKKPYGALFRKTTVENRSHLLEEEQNLFSTKDSSFGVSISQDIPNNLQFEHIFRLFSFLIPEKNMGELIENHDEQKVKYALTLDNISKMLFIQFRMFVGLPLILVGETGCGKTALVKYLFENILNHKFEMITVHGGIKIEEIEKLIQKAKADSTYRFILFFDELNTAPKPYIQLFKYLFKDRTFNNKMIPPNIQLIGSINPYRKRREIDSKISNMDDFDLVDDFQEKREEYEEIRNAVYRVHEISNSLKQVSIEFGSLKDNEEEKYINKMIKNAFLAIFNNDENKYNSFENQREKLEKYIRESQKFMRTNQNIKNLDENAQTNLASSVSLRDVSRTLRVFRWLYESKAGKFLLKYDSEKITKKELMERALHLSLFICYGSRITQIKDQTHLTREKYYKSIFGETAKDSQMVIEKVEDHFIEILENKTHFKKRMIASNTPLKENCLLLFVCIFAQIPLFIIGKPGTSKSLSAELIFEAFKPPLMKNKLAMDLHLQTIRPSFLQCSAITTTRGIEEVFQIAKDKTNDEDLGVVILDEVALAELSPDLPLKVLHSKLEHLEKQLSNIIEKNGEIQEKLKELKEVSVVAISNWTLDPSNTNRGILIRRDLITDLEMTASSILQSLNSKIPSSLGNKLTKIYQDIIDNQEKEQKNQQSNSQKKRSYFGLRDFYYFVKMIGYCIKYHGVNIYKEIIELIEKKNRTKEIISQNINRLLFNQLGFSDENDIPHFSRHMMILTKICNLRCLSDEIKKMKGDQTNFKMFIGSSLESDNSPNKIIKKLHKVERMISKGDIIMLCKSENLYEPLYDLLNQNYQEENKVLYAKISFEHVVSNLVVNPGFRLIAISEAQRAYEKESPAILNRFEKYYFNPKEFIKEDIIEEFLRKQNKKIKKFRKIFKMRKDQLFPGFHEDLISSLALKLQNEIKDLDINTNNKNNDDNDDNDDNDDNDDNDYNDDEEEYIKENGRKKWMRICSIDHEELRKKKEDIGYNEKMKDFYKEYKQAKFSNIEKLLPFLLNQKIRRSIILTFSETENLSSKGKEFFKLNIGEMNNISDFKKKIKEFLEISDLKSQSKIKSKIKSKIKSKTKIKSKNNNNNNNNNRKFLILNFSVSEKLPENIFYRFKYSLDNLLDKSLPQDLTSNDLDYYFIFIVHLQQQSNIPFHISFEQFWEYFFLKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R690</accession>
    <name>A0A9Q0R690_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol n-acetylglucosaminyltransferase subunit p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5068021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R690"/>
    <dbReference type="OMA" id="LYVLWAY"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016542">
        <property type="entry name" value="PIG-P_GPI19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008765">
        <property type="entry name" value="PIG-P_GPI19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="9">
        <location>
            <begin position="17"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="151" mass="17771" checksum="DEEF3BA971BF32B8" modified="2023-09-13" version="1">MDKKPSIPQENKSSAVAYGFSYWMLLWVSLGCYFLWSFIPSRIYESVGITYYPNKYWAVAVPVYLYVFFALVFLMDLMFILLLTEPLDSFNTISDFASIYRTEKDPDSNKIEFNHIHEKDNEYLHKVPLIEDIPITAVNELLFRNRDGNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6M8</accession>
    <name>A0A9Q0R6M8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_12286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6M8"/>
    <dbReference type="OMA" id="DNGNRMM"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15861">
        <property type="entry name" value="SNARE_SNAP25N_23N_29N_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044766">
        <property type="entry name" value="NPSN/SNAP25-like_N_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF79">
        <property type="entry name" value="T-SNARE COILED-COIL HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="124"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="231" mass="26570" checksum="AF2FD4C6B9087154" modified="2023-09-13" version="1">MLDEIEDYDERLTKICNEISSSINSLRSLKGRSRDQKSEEISDQLNKAKTLYRSFKAELRELPFNEKESWQKKSSQHNDTITGLINDFNYVRETAEKDELMDGRTDNTVDKEQMTPHQLLDRGLNIQDESLESTNRMKKTIAQTDQVGMNTLVTLNEQTEQIQRISEGVDKIDSNLKIADREIRLFVKRMATDKCIAVLFLLVVLGFIAVIIYAIVKKNKPQNVPNSAKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6R5</accession>
    <name>A0A9Q0R6R5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcineurin b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6R5"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="22654" checksum="B7F247D03BD5DD4F" modified="2023-09-13" version="1">MGNCFTKKEKNLEDHFINDDSRILSEDFDRQTNSTQSMDKKKFIQSYVGVTGKIENQFTDKIFKCFTHNTRLTKYELLIGLSKCTSSNFDEKIKFIFALYDSDQDGFISRTEFSQTIADFFEINSAQFNKKIDFSEDIQNYVEKTFNEISPLMKNIISYHEFKTYCKQNRIFACLGGVFWDIRKIVKDKKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R786</accession>
    <name>A0A9Q0R786_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molting protein mlt-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R786"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="761"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="794"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="889"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="555"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1089" mass="125638" checksum="1E0AA5B8F95284DE" modified="2023-09-13" version="1">MNFLKKSLENKNFEEFNSILNLNSSFFRYKSTNKSNLLHLTASFRVEPEFYSILLSSGLDINSKNQKGNTPLHIALDSKSSLNTIKYLIENGANPDEINKKNQTPLFHAIRSRIDLEVIKYLVDLGVNLEHEDHKKNTPIMFAIHEGKDMELIKYLLSKGVDISKKNSDNATLVHLSCRSFPQKELLEILLPLDIDYRNTDSWGMSPLLYLCENKRGDQAFDTLFAYDFDVNENRTYGDTSLHFLIKRKASLDILKTFVSAGVNVNKPGLNGLSPLHVACSLKDNFETVEFLVNSGADVNSKTWDYTTPLFLAVKNSLDYKTIHFLLKKGAKASITLRETNQSILHIACLKNAPLEILKLLVQFKADPSCKNTQYLQPIHYLIAQKRDHETIKFIFDSMPKVKKFDHYLFDFVEFAINSKASLETVEFLASLEIDLHHTRSFKPLTFLALENGYREDMLKLLFKLGVSINAKNSQDDTILHLACSQNNNYDLVSYLLSFPQVPKMINQKNNSGITPFHRCCFPGFHPKTIRLLLNLGANINLCDRVGYSPFIFIYENQNENQNQNQNQNENQIENQNQNQNQNQNQIQNQIPLRKPTHQEVVEIAKLFIEKGANISQINSSKENALNLHLLNPFINIELFKLLISHKIPILSGDLYSYPRSCLIQIIKNSHSVEAMKILLEHSFKKKQINDALFFTCSNCFDGADQIVQLLLDHGAEIKYETNRFPKNLLYTVLNQEKKSAELVFLILVEHEKNIYKDAPNEEKLIHVAARLGHVNAIKKLVELNMDVDAVEVHYQTPLFHAASHTQFDAINTLLELGAEPNHLDFHKRSSFFLLFEPAPRIARKFFEFGFEIQNAPDTVNKKIWKEIYLEVNSICNDFLKLFHSQYLVDITFYCQNGEIKAHKLIISHRIDKNQTTFQNLNQILRTKTKEEAKIFLEFLYSGKIEQTNEKKNIPLIKEISESIGLTNWKSKRGSQGLIPDLKKLYEDEETKDFSIIVENQPLKVHKIVLYARSGLFQGMFESVNDSSNKVQDYTNRSFESLNNFIKFLYINSLSRDLSDNILIELWDAHEYYQLNEYSPFQKLINLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7B9</accession>
    <name>A0A9Q0R7B9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras di-ras and rheb family members of small gtpase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7B9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="189" mass="22029" checksum="4AEBACBE16F97796" modified="2023-09-13" version="1">MTTNIRVAVVGDGGVGKSTLAIRFIQNEFIEEYDPTIEDIYSKEIDWNDSKIKFLVFDSAPQDEFYSYRYYSLRNQEVFLLVYSVTQKNTLNMIRDLYDRITDYVSDQNKDPFFILVGNKIDLFTKRQVPTHQAKAFADELDFGFIEISAKTGQNVNQLFFQIANAFCNRKSYIDSLQAKKKKKNCILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R837</accession>
    <name>A0A9Q0R837_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R837"/>
    <dbReference type="OMA" id="FSFWSEE"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="336" mass="39511" checksum="9CDB748958A865D0" modified="2023-09-13" version="1">MESKTNKVKNSAKFISENSKHVKINLEKIQNCSTFLLSFLKEKKLDISNWHNHPLHPSESNEKTLDWIFLVDTLNFAFWSNFIVKYKENQYSGYSALLAAINRAIDNTIPITQPEFLSKITLLDVEKIFHSESEQILLIDKRCEFMNQLGQVVLKKFNGKFINVVRNAQNDAEKLLDLIIENFPSFRDESVYKNQPVFFYKRAQILVADIWGCFEGKGIGKLDGIDNLTMFPDYRVPQCLNYLGIIEYSDELMDLLKKEDCFIEQNSEYEIEIRGNSVWGVELLKNETLKLIEKDPNLQNYHLNSVLIDFFLYDYAKKHHKEMQHIPIHKTKTWFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R869</accession>
    <name>A0A9Q0R869_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R869"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="375" mass="44350" checksum="0AF78AE669E238F7" modified="2023-09-13" version="1">MDSFLFSEQKQQVVELLLANISLKIENLNYFSILIQFLFRSEIPVECFLKQNDEWIPCFLFFTNEKLKLIRSKTKQKILSIYLLNNTRFQANHLQEVENIISITPYMQKTSLIKFPQEFQSKVILDVLRIILACNQIEMDLNNFSNINKSSELLDEKQFIAAMIIYHWARKTAKFKVNFNEKKVDLIIKQNKVIISSPPTIKTRIPIQLNFRIFKNLQDSKKFKIKTIGKTMDQKKEKSFEISCENEESRDYLISLISLKFRIPSLKFIHHLFSLNQGTNKIDNSNLFEWSSSIKFNTQKILQDMNILIGTQQLKLNIFLFYKKIPATILLEKDYFYIERLNGDNFKCKYEDATLLMNKKFTSVLLLEIQVNLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R874</accession>
    <name>A0A9Q0R874_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Syndetin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R874"/>
    <dbReference type="OMA" id="MAKVKWD"/>
    <dbReference type="OrthoDB" id="10263345at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="6">
        <location>
            <begin position="45"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="5">
        <location>
            <begin position="826"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1082" mass="127693" checksum="CB1D7027A54D7B9F" modified="2023-09-13" version="1">MSNKKQQKNQNQNQNQNQNQNQNKLQISPKTNRQYTIDNEAKILSEIPQKHYKQNFRIEKELFSILSRDFDENEILQKKNQFSFMFQAINNWLSEKVINSYDKFVEEISKINEIKQDLQISGIYCRNLRGKLEESRNNLVVSSFEVITKQRKRKFLLEVINQLQAIREVKRKGESLSEILDNEDFSIAIRECDELQRSIKSLMDFKCLQDIRDFHLEGYNLIQEKLDQSLAKQSETFDPQIYVKTIEGYQLLNRESQIKDKQHKYYLDLISQKTNQLIISFVREGKSKQEKASLKKMNYARLLSYLNESNFLNCLISIFEAFTNILDNFLQNYQWLKNNRNQNRTIKTLGRAFSQLRIVIWDNLQEKIVTAITSRLNQGKSYNLGLSSFRVDNFLKVLYVLDIFIDVGSNFCSFKPDKLQMIKNENKSKNKNKNKNKNNISDENNIDSENEYNENENNNNNSNNNNNSNNQIYPNLESDQTEKIKSPKNKKTPKSTEKKSRQLFEDHTLKLRQTMRNRSESYFQTFHSLRLDDIREMISAEMWQRCPTSPDFSLKDLAVSSYFHSIRKHSHHQNEDHIDNQNQNSNIFQKFNQESSNPFSQKNINELLGSSQQKQSLQKSQNLNSDEDENIDEQLKQDFIDEDEDSHLNTKSTIRAQLSPNKHQYQQNQDYEQSFNENQQTDSFEDDLKGPILTSVSINIVKFIGKYIKLMEVLQPISMQIFVGLTELYEAYLFSVYNFFATSEIQKQQQQLQSQLQPQTQPPLTQQHHHHNHNYQFDITTEYNLTDEEIHKIKAITQKTTIFQRIFSNLILSPDVISDLNSPEELYGLRYRIISIESVIFIQKSLLSLKDRIQELLGKQLDENPIFFQKFFTDLLNIPPRFQKYMYQYSVWASANFGGILHSISSIKWESGMMGAEHSPYVNEFKKEIVSFARRLDFIDTLSLPKEQRKTIWDFLVLLIMKLLIEGYSRAKKCSNEGRALMSLDLSTLQSTIKEISKLNSIPYVDLVDNYIKAFYLPSKEFIRWVRKNLDKYPEKQVANLLLCGIGQKMKRKERQEYIAKIQSIYQNQRRDIIADFSNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8S8</accession>
    <name>A0A9Q0R8S8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NONRIBOSOMAL PEPTIDE SYNTHETASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="967"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="2204"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1422"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2305"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1422"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2327" mass="270011" checksum="5CE0CFCE07B89525" modified="2023-09-13" version="1">MDTIFWNEEIKKIQELSFYGNEKNEKNAISFISSYCFLFQKYNLISKCFPKFSHFDFFISSFTFLLSHFVATDNISLAIMIDKIEGNEERKKITNKSKKIQEIKQYKDTLYSKLLENFNKKNPTRILFIFDSSNIIENFENSKYVLDQSFESVDQENAENSEQENTNENNKPEKNGVKKKYEYKALEVFDLIILIVDEEYSEKSDIETKIMFHNRIVFNTARFRDSFISLFTSHFTTILDKLVSSKEDISLHSFPLLTRFENQKIIQKWNKNFQFSNIPKQQKLGKKNIIQFFAKIVESKKTAIAIRTLTKKMTYESLDMKSNSFAKYMKEELNVKSGSLIGISMLCSIPSTITILAIIKLGCVYVPLDPRFSNKLNSKLIKQFGINLLFTDQKTQDIFAGIPQILGDDSLKIMCLSEDTIDNIHKDSNDKPQQLSTNINAIKAEDNACILVTFSDEGKPLGIQITHSNIINKSLACYEHFRMTSSIAHYSPLSSERAIIEMWGTLLNGGKLAITSKKFVLSNNFPIITKFLATKVIILTTFSFRRILSKELYNIPQIEALINEAENFNEIEKEKEKQKEKQKEKEKEKQKEIPKKKQQNQNQKIDKNDESSDSSVDFEFFEEDFNDQNQNQNENQNQIKNENENENENQIKNENENQNQIKNQNENQNQIKNQNQVKNENEKLENSEQELKWPFEEFEQVIVYGDPIDFELLEEFMRLEKKPKELIYCYGIPENSSIISVVKLYDSEIKKNGLLQSVRKSTTNAGPIGKSFADTEIFILDEYYRPVPPGVKGILFVCGESMCSGYYENEEMTDLLFVDSPSGGLMFRTGETGCILSSGELEHLGYQEKEINSLYNQDERVNVWGVENILQNHPKVSEVIAVIRDPQQQSLRRMIACISPNTEVPPSSTELSTFMKEHLPPSWIPDSFSIVDSFPTNNDGKIDRLKIHTTRDAQKGDRKNSERALVRPTNEVEEFLCQTYASVLKYERVSINDNFFVLGGNSIDAMRIVSKAIRAGVKFTYQALFQYPIISDLAAFVLKNKFNIADFAINSFQDLKRNESVDFFEENEGPLSPVQSWFFEQNFFQPNQYNIMTVIRLKKDVMIPIVEKSLNLIYDHHEAMKMCFLETKLKRKMKINAEIKLSFAYVEVTPNTPTMSQMCSQLQKSLDITNGPLIRFVAFKDLDDQRYLVISSHRLIADLESMRLFSNDLDDAYHQFMTNPTQAKLTSKLMPHFNWISEQFSEEPSKEGYSFWEKIAKKVSDQNTVKYLPREGQQWIANLQEYKSSLVLAVNSKITSDLFSRICRNQPDELIAIILTAISLALNKWTGSVHQFFHLFVSQRKTNSSIFNYNYSKILGWQELLVPVLLSFTAPGVNSDKKKALMVVKQQVYESRKFLNQLNSLLYTGFVENLIVEKEKANAIESTNQANEPIKGQTKQNKTQPTRTKSKQDDKDSFNSFFNISGTTTEKRDISDIDQLLAQIPNDFKTVLESLKKSEISFTFLGDIDMPDFSLGEVQHWPVVDNSVFGSFYPQQQTRSYLINIITYIHKGALHFKFLFNHKTNNPQDIRSLATNSLKILSKMYKEFLKQEELNSIINFPFSLTSKTSIIQAILSEDDKIEDVIFPVRGQHEIVQFFHRKNQIVKQHFCKQLILSFHSRKFHTEIFKKALEIMIARHPIMRSYFIRNPSDDDDDDEDNFTILQITRKSVELNWKEISWEKYDATQRFNLKASLLKDDRQKTFRFASPPLYRFIHVIVDGRGEHLLIFSFEPFMFDFWSLPVIIKETFTLYTALVVGGKSSVPMPTNIITSKDYVQSIFNNDSISDGDLSRNTEKDSEYKNESESDFIHSEKEDPILKQNRPSFPINLIKNPSLMYLKYLEWEHSTKIVEAKRFFKHIFGDVDFSIPITKKRTTPFGDKGEMIEDNTEIETESREITGQFHLNATPFHEISMRIDASKFEKLKEIGKSNQFTLSSIFHFSWAIALALHSKFSNVCFGTYITGRPPILGPGIEQMIGYYSRVLPFRVALVKEQSVLNHIEQIQLGLSKTAYFSNTTVSQIRKWCGLHETQDLFDGGVLLVEKYPNDLIIPIRDVGENNYIFQINTEKARLTFQKISIHESLRYPLLLVVYCDDTANEILIRLIFDKHRFEADMPPYLLKLFINTLISINENISLNLNDFLKDLIQAETVKQTQPAEKKFLPDTVFDPQKVLKSGFLRKHGGTGLKSGWRKRWFVLKNDQCLYYFKSKKSTHLCGVIPLKDGSIEFLPNHKKKNCFKITVEYRDYLVYSDSKEVTNDWVKLISDVLEQMKNEKSKEKEKDKDKDKERSKFFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8V7</accession>
    <name>A0A9Q0R8V7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8V7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="222" mass="25261" checksum="CC08EF418EDF3A71" modified="2023-09-13" version="1">MNPFPELMFQKENLNGNLNGNLNGNQNQNQNGNDNEFVSDLGIGNQLQNVNPDDFSFINQSQNVNPVDFSFLNQSQNGSPVDLSFLNQSQNEIDTENYFANFPSVGIGDNIQKSSSNSDCFIDNELFPLFGATCHFDEGFDVPEFDPKIELELDPELYNFPNQLKSINQNQLKSINQNQLKSMDQNQLKSINQNQFESINQLKSINQNQFESINQNQFESIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8X5</accession>
    <name>A0A9Q0R8X5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear pore complex protein nup133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8X5"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1148" mass="136086" checksum="DA8682E3A0363BA7" modified="2023-09-13" version="1">MFTLTPRKNLRNEQDSSFRKHKITQKQESNLIHNSMLLFSIPTSSRKTQKIQQHQFTNFTYQLSKIQNLTSQIINPPPQNITQNLIENLSQQYSFPCKLFSNGFAFYISNNFITIWNIFDKDSLKTFPICDEKNIQSFNQNLISIRHFVPKNQTFQNVFLTTFQGNIKYWYQPNNSNDVYYLTSSLELENDEEIRLTFPCSGYNNFFQKYNLYDLHLLITSHGNLIIILFKYKSSNSSNDYLEITTKKIHQSSQFLSGIGKILSPWNEKKNQTQINQLNIDEITRVISVSDESIIILFHSTFQIWKFHFEKELELKQEANFDLKAKIITKLKKLENIDYTIRFIDISCENIDKILLFCEIFPPDETFQESTQILVHFFINNKKLKIEQIQSIENKDETKFSSAKLFSLKNQETNFIVYPRELIVYQPNNFDQNLNQYSVLSLKEPFIGAIKSEKKIILLTLKNTIFVEMKTGEQRIEENIKSSNEIIFPKEKMESRDVSPYLRYIRDSFQAFMNGQKLQSQEILMQCVFFIVDEVPLSGPNWVETNDFGATPILLKNQLKSKNEQFDIFIQYILYNSIYSALSAKVRLEILLMREKLSIASDTYNYIQRLSSEQQQQQYQIILKAMNRHLEIQSQNKENYLFEGLTTTERCFGNVSQIQGFVHCVIEEIKDLESQGVRFSYDQKMLGIFGHLAEILVLALTSAKQYQEDNIMLYKQDGQFLNIKMNMNINMNMNIKMSKRKNKKQLTNRIKESDLIDGIEIEEAQNIVTEFESLQDIEGDIQTLWETMKNILIDLTKLKEMPQTNDHLFKQFRIISDHYLSQFPKLFNSPKMDLIRKNIIQNMINFKQYTTAFHLCEKYFEFDTLILLCHQLNKVDKIDKFAEKFEKYNFADHLFKYYIDTKQETKLLTLPSKYNLKLKNYLARNQSKNLKFKLCHLDSQETNQKENSLFNLNREIRIAELHKKLEYLIDETRRKKQDSILNLTEKKPVMDAEELIDSFLNVDHQETQLKFIFALEVFDSTILQRNESENFRLIFKIWQEIVKSGDGRDKKTIKWWSHLGRKVKSGIDDVQFNNIAFQSVFFQIASKILNYENLKKKGDLDFELENSHLILNENILNELVKKFFGKRKKMERVFRRVFELAEEKEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R957</accession>
    <name>A0A9Q0R957_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab3 interacting molecule isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R957"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="859"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1194" mass="142377" checksum="97E160B0FCB086DA" modified="2023-09-13" version="1">MATDLIGFVVDGIKWFKEQFDNKAKAGKIVIQVLGRIDRLTKTIQFLFPQMQIIPQAELSEIQKDRFKISCNNLQEEMNKTSLNNKKRELVQEKFKFFQISFKKAYLDILIQKQKQEQEMNLNQNLSKKQKKKQEKEQEKKKEKQKNYYQIIISVFYEFLIEDQIKKLENENEKLENNENQSKKFINLTTFLEILKGLFLTVSKYAKKGVFARLTSSSGFLEDIEEQNNLLDQSEQDLSLEFTIKHRAELQEFKKILESTQSPNQIIQPISSNIIINIQNQNQNQIQNQIQNQNQNQNQNLMQNQNKNQNKNQNKNQNENKNENQNQNQNQNENENKNENENENQNENEDQKNNQPNILDSEKTYSKPKYQSSIINTIQKMFCLNDKRLTTVSDIFGLNDKQYENKSITLIEALNNFKKTSIREKAVKFFEIFDTNHNELLEENELYEAFEQILNVAFFLQFWLSYKKQEKDISNLSSNEINNIEFQIKELINEQNIISKVHEIFQGLPIPKKEQEGVKLEDFKNHFIFYPKNEILKYFGDFENTFFECFKFQYSFLFEDTQEESKEESKEESKEELTITTESDSDIESKISKESKSKKKESEIKSNNPTIPRFFDVKKEPTKYHKRKNFNPFSISMDLTKLPKSSKPKQQNSNIPRFSDGKKEPRKPYQRKNLNLLSISMDLTKKDETEEVVQKLTFIKRKYQNTTNITHLIKQPIKIDGQFYEKSEIENTSDTKIDTKIDTDFYNKTLKWALKRIEKCFEFLKEKEEKIPSLKKIEILKFALGLTTDLYDPKPEDKSNDSQLILKRKQILKQLCENFKSQNDKIEESRHKLLLAKLYKDEKKIDKDEKKSFKVFNLFKYAFENVESLNEKIEALENMIEITNDKEQKATYLLSLIHLYFDTQPQKSKELLQHPIFKGDENNPKFEEDENIKKDLRYQYLILLRNYNKSYEDEKTSKESFIKLNEWCRINYPAKYQDLNPKPKPSQQKIKISKNLRFLETKIQKIEITPKIYSNSVNSSQLKLIEFFDKIPQILSPKNNLENLYNSSQIHFDEIIQFEKPKSSLSKSSLPKSLLSKREKETKIFKKEIQKFWKKMEDTAQYDELHKNFTTLRYATNLEEIHTKLNKLEKLYLYLKDPKKNLKIEQIRELVNFIYQEIGEISIKFKQFHQISKPTNLIEYNEQTNSKDNSYKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R965</accession>
    <name>A0A9Q0R965_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R965"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="49"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="348"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="525" mass="62617" checksum="9A0D9FC66D598AF8" modified="2023-09-13" version="1">MDNNNNNNQIENANQNQNENENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLLQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNKKLKGKKEKEKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDIFPKSFLIDIQNKVIQDNQKENQQMKIEIEEKWKKEVEDKNKEIEEKWKKEIEKMKPIFDKYRDQHFSDSEIVQDIEYVKKLQEWINDNDFFYKMKKGFSAKRDGFNCQNWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGFNGTTEWTNDSNAFIFSLRNDKGDRIPAKFTYKQNYAIFCGLSYGPLFGYNIGYYWDFGLNSDLQPGYSNIGYSYNPPNGITYNTNESKSYLAGSPNSWVVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9F7</accession>
    <name>A0A9Q0R9F7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9F7"/>
    <dbReference type="OMA" id="CLEFYEC"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="251" mass="27591" checksum="D6E7884803456D54" modified="2023-09-13" version="1">MSVPKFSDEEALFEAAEEGKVSQVAKLLKKGVRVDAENQRWNPLLVATQEGHEDVVRLLLENHANVNHQNKGATALYIASQEGHQEIVKELIKKKASIDLTNSGATPLLIACQEGHLEIVRELLNAGADVNHADSGDTALQYAVSNRHLDVVKELLARNVLVDVQDKYVKKNILIEFWNGDTALMLACEIGLVPFVRELIKANASVDKTNSGNTALDLAEEEEIKQLLQSKIKKKTRGAFAKCFACGQSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9K1</accession>
    <name>A0A9Q0R9K1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iq motif ef-hand binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HTHNWDF"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="809"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="877"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="538"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="694"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="760"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1316" mass="154312" checksum="878DB3810A7B1794" modified="2023-09-13" version="1">MNEPVVIKCSNPFCGVTKTPLWRKIGDEYFCNACAVYRKRHGKDRQVGWRLATDKEKDKDKEKEKENGNKKKKNKKKKTRKKRKGKTREKKSKAKQNEKKKRKENQKQKKKKKTKTKNGSEIFDEIDQLKTENDIEKNHHIFQEFKNPQISQSSHLLPFSLPSLLLDTPNISQIEIQKEIEEKIETLNNSEATVRFNLINQKAKSDFNLRVIQTDSSQNKKYAQLLSLINSFTQTMEHNKDDLNGNENENLNENQNQNQNQNQNQNENENENENENLNENENLNENENLNKNENQNQIENQNQNEIENQNQNEKNENQNQNQNQNQNQNQNQNQNQNQIENQNQNQNQNQNENENENLNLNENENENLNGNENENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNLNENQNENENENQNQNQNQNENQNQNENENENQNQNENENENLNENENQNLNENENENENQIENQNQKGNENENENKNENENQNQNQNQNQNQNQNQNQNQIENENQNQNQNENENENENENLNGNENENLNGNENENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENENENLNENENQNENENENENQNQIENQNENQNQNENENENENENENLNGNENKNQNQNQNKNQNQNQNENQNENQNQNENENQNENQIENQNEIENENENENLNENGNQNQNENQNENENQNQNENQNENQNQNQNENENQNQNQNENQNENQIENENEIENENENENLNENGNQNQNENQNENQNQNQNENQNENENQNQNQNKNEIENENENQNQNENLNQNQNQNENVNSNSNSNINSNINSNSNINSNSNINSNLNENQNQNNKNQNQNQNQNQIENQNQNQNQNQNQNQNQNENENEKNIPKSISLTNPTIDKSKKDTFNQLKEESSVKNEKNQKSSIPQYLTKLKTTEKNQIDLSLDKAQNQIILSVNTQEINDTSPQNINDHNQVHSEKISYLKKENKNIGNNHHKNSRNNLQKNNNRRNRRNKTKKETQQNHVKKARSKNKKSRSQKNKKAKTQNPKSQKNQSNSNSNSNINSNINSNINSNININSNSNINSNSNTNTNSNINSNSNQNSNTNTNSNTNSNQNSNTNTNQNSNINSNSNSNSNQNSNSNQNSNINSNINSNINSNINQNSNQDGKTPKKYFAKSKSSENVDFFFEQKKREDTMENAKKGSDKNIQDMILRIGDCVGMRMEGGIEIFASIKSFGSNNHISLNQCFVKWLIPKPSISFDFFEQEMNNFLTSDHFFEGRDEELPQPIESITRKLPFRIPFTSNKKGRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAB4</accession>
    <name>A0A9Q0RAB4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAB4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="459"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="564" mass="66262" checksum="E6DB2BBF47EF846B" modified="2023-09-13" version="1">MIVYFLVKINIPKLIKNEPDTIKKPIQFKFENENEKQIKQISLSYFSTIFLFENGKAIEYLSKNDSNKNPEKIQIEENIQKVTVGYHNEAILTIEGNVFAKGNYINPENPKQFINISSLIEDINDRIIEDIVSGDSSIYLLTSNQNVYGIGSNEYGQLGFDSETLEKTEKPILMMKNVSKIFSGISSLHVFLLNSNQELFGCGDNEYAQLGLGESRKYEIEIQKLTKIQNIPKGEIIDIQCGYFHSIMMIENENENPKRKLYSCGYYQYNGLGKNMKILMNLLKSNHLYLKIMIFLKFLNDYGQLGTGDTNNQLIPIQIELPKLRFNENISNYHILCGYWNNSFLYYSPPSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIKITQEIINEIQIGIDYFQLNETNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAP3</accession>
    <name>A0A9Q0RAP3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAP3"/>
    <dbReference type="OMA" id="YENILYE"/>
    <dbReference type="OrthoDB" id="5431422at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="339"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="574" mass="66241" checksum="66997E57B14234F6" modified="2023-09-13" version="1">MDIWEILEREDFKLLKQFKSIPQNDLIKNGKSILNFAIKNKFPLKIIQILIEKGADVNAKDSSNMNSLHTACIYTDNIEMIKYLIEKGADIDAKAVESQTPLHFALTYSEKENLFEIIQILIEKGADVNAKKRFEDTPLSLAIYKKLPLEIIKYLIEKGADINVKMNSDLTPLHKLFFEQREDIFEVIKYLIEKGADVNAKKKEGETPLYFAILHQLPLEIIQYLIEKGADINATILRNETLLHYACENNPSIEIIQYLIAKGIDVNAQTYQKVTPLHLACKHCASFEVIQYLVEKGADINFPNNENQTALHFACKNQSLKVVKYLVEKGADIHAKTDENETPLHYIGENEDRENEIVDILKYLVEKGADINAENAQKETILHYVCGNIEPQNLVSYLISQGLDINKRNREKETPFIISVANENYEVMKILMMNDVNLEYISEFVNQEGNIELFLQIYSLNDDLNKLLKSNDNFSNFEIRSNDSSKFKVDKLILLTRFDNNQNILNEFIKNCENKPKEEVEIALNFIYTGFPDFEKIKKRFGTNETDDSDYSDESDYSDEEPKPKKEQKVLEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCN6</accession>
    <name>A0A9Q0RCN6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCN6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="22620" checksum="A153B3D725E30133" modified="2023-09-13" version="1">MTDKKSKPKNLTDAFRIILEIIDKSGQYEDESKFRDEFQKEQSSKNEKEKAKNAKEQEANNLKIEIQNTNQGIINIQKEVDELIKKIDELKSTQQNKNNEKNKIKKDTQTLNETQNQIKILNQNKEDLETKIKGAEPIIEKQNKQIPTLESKSESLKKDLEEKKEQLKNAKQTKPDLKQKQEEEIKKLTGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCZ5</accession>
    <name>A0A9Q0RCZ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_07793</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCZ5"/>
    <dbReference type="OMA" id="AGNHHPW"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ArnT-like N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Protein O-mannosyl-transferase C-terminal four TM" evidence="11">
        <location>
            <begin position="231"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5075088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="462" mass="55104" checksum="FF25B3497AF19427" modified="2023-09-13" version="1">MSYISKLCGNTPTFWFDSIGSKFPSNFNYFCLRAQPAFIGSLIPSLIYLIIRIMHGSIISALVAAAMMLFETSIIVESRIIATDAFLFFFISLSIFFGKSQTLQKYPSFSFYLFMFLTAFSLGFSLATKLTSVATVFAIAILQLLDLYKRHFSKKTNYKLLIKDITIRILIFIITILVIYLTAFFFHFNLLPFESRDDEYIPFEYKPKDLIQKNTFENQLQSSKKFRPFYFLYKVWKVNKDMYKANMAINEKHSYSSPWYSWPLHFGKPVLYWIKYDSTNISKIESIYCIGNIIVWWLVFTGVVVYVFMLIIFHFILRRHKKKIEKKILDHSQKITKIKNEVFYHKFDYLQDNLLLHFDSLCFLLAGYLFNLFIFFPISRPTWLYHYIPSLIFGILLFSLLLDILIRVYFPDLIWKFLIVSILIFWTFLSFVFFIPFIYAFPLNPFQFNERIFFSFWKPKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD92</accession>
    <name>A0A9Q0RD92_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD92"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="214" mass="24861" checksum="BF415DA3BD667306" modified="2023-09-13" version="1">MENNQKKSKTKLTLQQKSIEKLKTQPKQLDFKFKNSPKSFFNGKKKKKVSNYILYYSKKFPKYKKNFPDYKVTDIARQISLVWKSLDLSKKKKYSLLARQKNQQPLISSIIKRKKEIENENENEQENIFEEKKEKKDETKSKSKSKSKSKSNSNSKSKSKSKSKSKSKSKSNSKSKSKSNSKSKSNSNSNSNSNSNFKSESESDGYIFEVDQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDH7</accession>
    <name>A0A9Q0RDH7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDH7"/>
    <dbReference type="OrthoDB" id="6381660at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040488674" description="Fibronectin type-III domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="892"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="510"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="939" mass="104205" checksum="29333C298A26897F" modified="2023-09-13" version="1">MIKLFTIILIIFLLTKQISNNYELKKVGNQWNQKQIIYPNPLATEIAFGSSISISNNVMAIGARVNDINIPGRAYVFEKQNYNWIQTAQLPNNNNENSDEFGWSISISQDSSVIVVGVPEATVSVNVGQGKAYVFTKSGNEWIQTKELTASDGKAEDNFGYSVSISERVILIGSPYASVNGNLKQGKVYVWEGNDDGTIWQEKPTLTATNGQANDHFGKSLSISKDSSLIVIKSEQSNSQQVTAHIFQSNGTYWNEEESFTVNGLQEYGDWGGTVSISEDATTFVMGVSGDGYNQGKAYVFHYNGSIWNNQTIIPNNASGKCCFGFSVSISQNNLIVGDSDGTAYLFQNNGSGWNQERQWFPQNPADKGEFGKAVSISGDISAVGSPLLTYDGFDSVGGVYIYEFVYDQVNILNCSSLFSSFDCYWNEILPITSDIEYQINYNYINNEQWETIQSPILIDNIFFQIFNSSIYPNITGNVYYNIQIRICNSSSQICGEGSGSCSLTTRIDSVKNFTVESITTTSVMVLWNPPNVPVINFIPKLDHYLLFYQKQDSNETKNASISNSSTSYELTELDSLSNYSISICGCETDECLGIYQGEIVSTTIFTKFGPVLNLQCLISNSFDISCYWDKPNDPINPSYYNFTYQAISENDNGNFDTNSTSQNFTAQYSNQIYQINVSACDSNEICGDISSIQITSGKFGPVLNLQCSISSIYSISCYWDKPNDPINPSYYNFTYQAISKNDNGNFDTNSTSQNFTAQYSNQIYQINVSACDSNEMCGNISSIQITSGKFGPVLNLQCSISNIYSISCYWDKPNNPINPSYYNFTYQAISENDNGSFDTNLTSQNFTAQYSNQIYQINVSACDSNQICGDISSIQIGNQLTSSQSSNSKTVIIVCSTVIPVVVIVGIILMIVLIRKKKKKKNKEGEISMDYSVLKDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDN8</accession>
    <name>A0A9Q0RDN8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysophosphatidic acid phosphatase type 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDN8"/>
    <dbReference type="OMA" id="MEIYSDN"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040359894" evidence="3">
        <location>
            <begin position="16"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="373" mass="44050" checksum="131DBAE5AF3AA94E" modified="2023-09-13" version="1">MKFLFFLFLISFIICNKKLILVQVITRHGDRTPLKTLPNQKNEWNCDLNFYHLSNPESKTIFQKVYIPNRQQFNGNCLTGQLTSKGFQQHFLLGQKLRKKYFNELNFIPEKYDPKLIYLRTTDKQRTRNSVYGNLLGLFPIDINEEKIEVLDVNTVDLDYEYMHVNKILCPKLKRLLLDLENSSFWKERKEYKFLHEEVVKIFNDSSLLDTSLRKVRDNIYCTLSHGKPIPEGISYSLAAELVEETRWQIETLFVNKLISKLSVGLLIKDILEAMQNKIVEKIEYKYMFYSGHDTTLAPLLSNFNVFDGSKVYYSSFIIFELYSDDSNHFFVRFIYNDEVYLIPGCKSTFCEFETFIEIAKKVIPINFTEECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDW2</accession>
    <name>A0A9Q0RDW2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDW2"/>
    <dbReference type="OMA" id="WIPEIEY"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002060">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="523" mass="62414" checksum="0B327F2C9003BE6E" modified="2023-09-13" version="1">MKIKIKIKTKIKFKIKIKIKFKIKNQNQNQNKNQNQNQNQNQNQNQNQNQIKNQNQNKNQNKNQNKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQKSKSKSKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQEIEINFWDTEKDDYYLRLFPLYYPETDLIAICFGIDSYSYFENIENYWIPEIEYHLKNPKRILIGTKIDLRNNEERINELKEENKKLITKEEGMEFAKKIKAIKYFECSSFTQKGIETIFNEIALICIGKYDKKEKKKGFIFIGTGGIGKSALLMTYNEKSFPEQFIPTIYGNIFSKFQIENQEIEIDFCDIARNESYEQNLQKIYEKTDLIAFCFSINDYHSFKSIESLWIPDVEEYAPKNSKRILIGTKIDLRNNEERINELKKRNEKLITKEEGIEFTKKINAIKYFECSSLNQKGIETIFNEIALICIGKYKEIKQEEQKNKKGCILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE96</accession>
    <name>A0A9Q0RE96_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE96"/>
    <dbReference type="OrthoDB" id="188207at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="400"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="557" mass="62495" checksum="3FE723F961B2478F" modified="2023-09-13" version="1">MMNLGSVIDIKENKFCVIGTPYANVGNNTNQGKAYIFEKNGTIWNQIQILIASDGEENDAFGWRVSISNDGKYILIGSPYAKVGNNTNQGKAYIFENNGTIWNQKQILIASDGISNDSSFLVIGASGANVGENNLNQGKAYIFQNNGTFWNQNQILIANDGEKNDEFGKSVSISNDSSLILIGSPFADVGNTYIFENNGTFWNQKQILIANDGEEDLVLQLLKIIQIKENSQGKAYIFQNNGTFWNQSQILIASDGQEYDYFGSTVSISNDFAFIGAPNAKVDNNNSNQGKAYIFEYSSIPPQVNILNCSSLFSSFECYWNQIISNLNDIEYQINYQNGIENWELIQSPILNQNILYQIFNSSIYSNISGNVDYSIQIKACNISSQICGNISNQINLTTRIDSVKNLNFESYSNSIQLNWNYPNVPIINSIPKLNHYIISYQNLNQYPNQTIIISISNSSTSFQINNLESLTNYLISIYSCRNEECFGNDKGEITTIQIQTKQQNSKSNSKSKTTIIVISILIPIIVIISIILIIFLIKKKRENEQISLEYSKLIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGA2</accession>
    <name>A0A9Q0RGA2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5079002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGA2"/>
    <dbReference type="OMA" id="GTAHNIN"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF17">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="5">
        <location>
            <begin position="124"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="80877" checksum="C97213497343AF74" modified="2023-09-13" version="1">MLKQTINNFPTNLETYQQTGIPWGSIFQPLSKIKKSNTIESIDEILRCEKCFSFISPFNHIDINSNWSCKLCEYSNHSKIPEKSRYTFIGENKPVPKELAEKMVEFEIPQPKKTFSKSKILICLLIDLTLQIEEIEATQKTLIDLVQYLNGKRKIYVGLFTIDSRLGVYQLDSDVPFVKYISIPQNSTDSIPLFLEEISSYSKIFVEISKNNSNIISAIQSLSQNTSKNEFGFGSSVKYIVDSLIQKNRFIFTQFICFMGSVPNYGCGQIEEEEQMNPSTNYYQNIADIAGQNAMAFHLFPFRYVGLSSLKFLSNSTGGEIYLSDPLNQETIFNNLKNIVVQEKAVSCLFRIRTSPYFKVSKIFGKYCKDEKTENLSTGFEQCIDKCAYIQISFAYTFIPGIDEDENEDENQNGMIISNSLFEKKKTFHRYIRLYNQQVFFTEIPSKIFQKSNGENIIFLLTQKMIQMSLHNRLETARETLTQWLCSLVENYLLSNAENKRKEIEIEEELKEASEFIENPELHNLFWWIHGILKSAFFCVGSDIAPDHRIAYYSSLLSLPPQFLSRSFYPKMMILKNGTKFLLKNVRLSKNHLKACVQKFPKFILVLDRFWSLVVFNNFEEEIDFQKEMRELFSKWKKERKKCFFAEIRFYQELNWKIIERYLIEDENENGNSFEFFKEEIKKKIRNKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGJ5</accession>
    <name>A0A9Q0RGJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper transcription factor f-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGJ5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="220" mass="26393" checksum="F76030364D69B401" modified="2023-09-13" version="1">MLFGFNSNLDEFFEDLFEDPNTPNEKNPQSILDLNITFNYAEILGLRPETKQTEPKKEANQKDQNPKEILFDPKVEIQKEIQKEIQKEKEQKEEKEENPKKTVNKTKKVKREKIPKMSKKLKKQLEENQIQTIGNKEVDLGAKMSRKELHKLSPKQRKLRTLIKNRRSAKKSREKVKRRLEDYEEKIQELEKGNEDLQQKVKRLEKKNKKLKEELKKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHG5</accession>
    <name>A0A9Q0RHG5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHG5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="390" mass="46551" checksum="3D7F85329B20FB10" modified="2023-09-13" version="1">MNSKNRNITSNKSNEQPHFLNLHFQTDIGDFNENLNYIIGDSNHVDKFEDIDAFIPFDNFSQTNIFGYQNTLSPLHNPNHFDDSNIFNYFDDSNIFNSFQIWDSSHSFNKLAPFDGLDSLDSFSNLSFLQQKEKEKEIEEKEKEIEKEFEKEIEKEKEKEKEKEIEKEIEKEIEKEIEKEIEKEIEKEIEKEIEKEIEEVEIQKPQRIRTRRRTRNKRKKIEEEIEEEIEEEIEEEIEEKTKEKRTRTKRNQYEDLSPEKTKQFESAIKQASKKTNIEGETVVLRRLKEVGKILGTEFVYIEKDNEEISVNGKLTTWNNLGLEKGDKVVITDSYIYNEAKYRSKKAKHKKILETSIENVRRGFLSGFGKHGFEKYNTHKRGDMIFKFIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHI0</accession>
    <name>A0A9Q0RHI0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHI0"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="227" mass="26599" checksum="95C86D2329533804" modified="2023-09-13" version="1">MFEKEQKIFQNLTIFSKSQNKEEKEEEIIDFSFRIKAIQKIDTICSKLNFQNETFFFAVYYLDKMISSLPLTLKNQSDFAIIACVSIAGKVYEEEVPSISCFQMFFPKYHKKSKSYNQISNLEVELIKIIDSFIPTTVNSFLEYFLSRVSNFSSNDDIYTKMIKLIKIVIKNPISVNFFPSEIAASILSIYFPDDDLIIFVTGYSIKQLEECRNLFNLYNNNLDFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHY1</accession>
    <name>A0A9Q0RHY1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nedd4-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000003">
        <property type="protein sequence ID" value="KAJ5080712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHY1"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="191"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="274" mass="32662" checksum="764876E506CDFD52" modified="2023-09-13" version="1">MNFFIFLFLVLILIILIIANFQKNDKRKRKRKRKKQNILIQHLLNLINFLLEQFIILIKKIILSSTQKKNKNNNNINNNNINNNININNNNNNINNNNNNININKESFQNQLSKIIQNDFTETQYYSQLYSIIFGTCQKYNQKKSYEFATSIRKLPVKKNYKEKQKIRRIESIFFLEAYNPWKQIHTIKKIDLHEQKAAMAMQILVFFIEKFAQYLSKYQIVVGQGNHSQDGVPILKKLVIDYLEENKISYVLLNPGLLEIQNKKIEKMEKVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RJ90</accession>
    <name>A0A9Q0RJ90_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tether containing ubx domain for glut4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000007">
        <property type="protein sequence ID" value="KAJ5080594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RJ90"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="360" mass="42492" checksum="F9A357EA5D67458C" modified="2023-09-13" version="1">MSKKIQIALQIDQQRYIDSFNSNETLWDIIEHFDKKTNLLNRVHEEQKPKKKSIFKKKSKTKDPNIGKWEKPSLLYINKKFSDPIQMMKATLRSIGISSGSASFKKEIETNQTNQKKEIETNQKKEIESNQTNQKKEIESNQKNQSNEKNQYHTSKISIFFPKTSKEKSKTDFSPDFFKPSAQEIKEFIVTSQKKREESEMLMTQEMREKRKKNTMIYYPKTLIRFVFPDRILVQSIFSSRQTINDLYLFLKENVLTEKYKNQPFTIYISPPVNKFQNQMNENLHNLKLTPATVFYVSFSSQKDFSSFDAILPDLIQNIDDFKETILPQSNQKSKAKQQSNQNTNQPKVSDETLKKFIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L512</accession>
    <name>A0A9Q0L512_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000145">
        <property type="protein sequence ID" value="KAJ5066367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L512"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="645" mass="76507" checksum="1467C6C49DCCBF1D" modified="2023-09-13" version="1">MEIELDENNENEEETFQELKKELQMIFSLGYQSETIVNCLLRFKIIGSVQTYSTAESIEIVTQLWRSYFIDATAFLKAIEILRNQNNEDMKPPIPPLFENSSHILGDEHFYETDMDNSLDNFPFLERSYEENESEIDQVFSNHTYVNENTRRNISPYSGEQRRMRREQELGDGRESQNSSQKKKCSLCFQYKSKPHICPCENEMRDLGTLEIFKRCANNIREGEKRRYIYSRCVNNASEQYLEENINKEILDWKQTRRNNNPPKRTNPTLVNMEENLHILHQENDPEVKKQKLIQNQRRNNHISNITNDNLNNDRNKSNTTTITNNNNNNNQHHYFTNNLSNNTHANNRSNYRSQRRVFLPKRNESNTSRRLARIQTRSQSRIPDINENGKEEYISKSKSKSKSKSKSKSKSQTQSISISNSKSKSNSNSKSQTQSISISNFKFKIKFKFKFKIRIAITIRTRNRTRSRSRTRTKTKIKIKIKIKIKIKIKIKIKIKIKTKTKTKIKTKIKIKIKTKIKIKIKIKIKIKIKIKIKIEIEIENQNQNQNQNQNQNRNRKSKSKSKSKSTTFLKHQKPKMKSKKKLQFSEFSEQFQQTETEEQNYRGNQNIDLVNKEDHSTYKVIQQQQQRRFFVPINAEKESSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L598</accession>
    <name>A0A9Q0L598_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nuclear pore complex protein nup98a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L598"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="133" mass="15456" checksum="52249FBE3EEE68B6" modified="2023-09-13" version="1">MNQPITVKEGNIYANYYSICAKQGYGDFKEGNIYTNYYSICAKQGYEDFSYEEIRLDNNRNTNEDENSNQNTNITSLFGNLNLNSNQNSILNQNPITVKEGNIYANYYSICAKQGYEDRSYEEIRLENNRNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5N2</accession>
    <name>A0A9Q0L5N2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5N2"/>
    <dbReference type="OMA" id="FHYIVHC"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="139" mass="15935" checksum="BB9328B2BF7BEACF" modified="2023-09-13" version="1">MKIICVGIIGPQNNPLLIHTDFSGEERKNIEYIVYTALDFCEEKIPAMSGNKKSSLFESYLGLLFPTEDLRVYGYVTNTHHKYVLVLDDSDVKDVDTKKFFVQLHDIFIQAISNPFYNYGEKIESLNFISNLKSLISKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5Q5</accession>
    <name>A0A9Q0L5Q5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000142">
        <property type="protein sequence ID" value="KAJ5066453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5Q5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="72" mass="8734" checksum="E133F16C309D5D22" modified="2023-09-13" version="1">MAVFHFSELISFSNSSISLLKTRDEFFGFFGNSLTRFFDFDFGYNQKKMKNKCRLILVRFEERMIWNLMDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L662</accession>
    <name>A0A9Q0L662_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L662"/>
    <dbReference type="OMA" id="KFFCEID"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="152"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="257" mass="29497" checksum="1AC723221959AC98" modified="2023-09-13" version="1">MEFPKWIFEKQTIIENTPSRKEGIDFETELNEREETSIFILTLGKLLDLNEIIICTSQYYFHRVFLKYSFNKEDSNQARMMAAGCVLLASKIHECAKKTRDIINCYHFIITGGQQILEIGDHFHKLRADLVLAESRVLRALCFDLDIVVPNVYLLHFSKSLSLSQSTFKIASKLLNDSMTSILCLLCTPVEIACGCIHLASKISDKEIPFPCWYEVFGVDTNKVVFVVSEIMSLISKSNEQNFHNLNENQNENLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6Q2</accession>
    <name>A0A9Q0L6Q2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_13037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6Q2"/>
    <dbReference type="OMA" id="HAVINQM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5067367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="303" mass="34567" checksum="13A91D9948F7FDB1" modified="2023-09-13" version="1">MTGDPYKKKTIRISTIIIEVYYMFFFKSKFFAKVKKGSWAVVTGASDGIGKEFAIQLSQKGYNIVLISRTTEKMEEVSKTIKEKEPSRETLIISADLSEKESIEKIASKINDLEIEIFVNNAGQSNEFPLLFHELDEKTRKNIMNINAVNFVELTKLMIEKMMEKKNGLILTMGSLSAIHGAPLLGLYAGTKSFVLNFTNSLAYEYKDSGIKFHCFKPSFIATNMTKMRASFTVPSAQKFVRTALNRIGSPQIDINPVPIHRVIEIFSNFFVHFFMNYVAQIGRKLRRRAIEKQQLLDKSKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6X7</accession>
    <name>A0A9Q0L6X7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6X7"/>
    <dbReference type="OMA" id="HTRVNAR"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF17">
        <property type="entry name" value="RETINITIS PIGMENTOSA 1-LIKE 1 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="283" mass="33120" checksum="6B45AFD339F244FE" modified="2023-09-13" version="1">MNSFFKIKVKIEVKIKVKIKIKVKVKVKVKIEVKIEVEIKVKIEIKIKVKVKLKVKIKVKIKVKIKIKVKVKIEVKIKIEVKIKIKVKVKVKIEVEIKVKVKVKVKIKVKIEVKIEVEIKVEIKVKVKVKVKIKVKVKVKIEIKVKIEIKIKLKLKLKLKVKVKIKVKIKIKVKIKVKVKIKVKVKVKVKVKVKIKVKVKVKIKVKIKVKVKVEVKIKVKFKVKIKVKIKVKVKVKVKVKVKIKVKVKVKIKVKVKIKVKIKIKVKVKVKIKIEVKIKVEIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7Y6</accession>
    <name>A0A9Q0L7Y6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF445 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7Y6"/>
    <dbReference type="OMA" id="ISKAAHY"/>
    <dbReference type="OrthoDB" id="446769at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38568:SF2">
        <property type="entry name" value="DUF445 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38568">
        <property type="entry name" value="DUF445 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14366" checksum="2320BDEC93CACAF3" modified="2023-09-13" version="1">MDLLIQSPSVDHLIDLKLEELKQRPEGKVLSMVGLEPAKLKPLILPFIGGFGNSLSQISADAFGVSEVFNAENLRKEIDNLMTEKLKELTPQAVKALLERVIRHHLGWLIVWGNVFGGIIGIISKAAHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8V3</accession>
    <name>A0A9Q0L8V3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-secretase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8V3"/>
    <dbReference type="OrthoDB" id="19866at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="2">
        <location>
            <begin position="868"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1053" mass="124033" checksum="F19E85283579BF92" modified="2023-09-13" version="1">MIRLNKILNISNSIEKVVNIPTNQENKNKNKNESENKNENENQNQNLNQNENQNENENENENEIFNLDENLNENQRHNSSDSESNLISGDLVQSESHQRKFPLLKTYNNFGNITRNVVLVGQEFYPQNKNNTFLLVARDTISIDGIEKSYIDILFRETQERRVLYEHSGKFNCVGASLNQDQTILTFTIICDEQNIYEKYLYQTFLVVLNKKSEPKIQPIWNPTTNFQSALFLPRNSKKFDSFIFILDCTFIEVWNVYLQKTKNDEILKTSVASTIANYFIWFEFDTKTKNLFYLQNTKKNQGQILFCTSFNKKEPENILEFPLNIIFQSSANSSEPVLLYDHEYFTTGHISPNWSLKFNMIRISQSGYCFCQQNLQFHDQNTFFINVVLWILHHREQVEIHIPLNNIPEQYISRMRAFFGSLYQLLLIYIPSYFVQFVDCSKIHKTCDSFKFFGSENATPLGDISSNEFIPFNISPISIPRFNSFLKNSFIDNKTGNAYDFRINTEYLYHLDSKNNSETNLIYGLHIAHTHLNDDNRAENMILHLCYQNPKALTSKVFQEYLIGASYRQFQKQRPEKKLQNFFKFLNKVLPVTTILPFQTIQEKMNLRSSKQWDLNIKRFQILKEYQTFQSKLPSNKQFTYMDILEKLRKQACVDEKYDEESQNSCVGPIKNKEASPKQQQFVPFEFGFKTSQTESTQRLVQEAFYSHINSVYLPKSNYHRAKFKALTGLYFQSQYQVVEHIFGVLQIALICSDKALKKSSKNSHEAIHPINDLKFIHDLFKSKEFFESNPFYDHDEIAKTDTFDLDIFDEQFSALADEMETQTLQNSTSKDLRLAMITRESKSKELHFESNSFSNQDFDLSLIIIQQKTAFEVLSQFYFALEELCLPFPMNFHYHFCRLGFLCLSKEQFIQHLDSHIFYLDEQFVDDVLELSKGLSRNFKLKLMNSLNEKSMWNLAEKYPEYHKYLLELYSSQISNSLEKDYLTILKIIEKNITENIYTLEDPPFLDYIPLKMWITGLSTNCKNNHSREIAFLNNFSNLSVKDDTMKDQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L997</accession>
    <name>A0A9Q0L997_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L997"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="120" mass="14612" checksum="D06C285FBF0F79B2" modified="2023-09-13" version="1">MKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFEIFEYWIYSNQIKDEIEITQEIIDELETGIDYFQLNQTNPNLFDLLINKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9F3</accession>
    <name>A0A9Q0L9F3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ICALHIM"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="9">
        <location>
            <begin position="1464"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1880"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1669"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1882"/>
            <end position="1892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2209" mass="261831" checksum="5DFAE2CA7C573CF6" modified="2023-09-13" version="1">MNQENLISQKNEPLVSVLAVSNWQLDPSQTNRGILLRRVDPNSSELFSTALQILRSFDKRFPKNFAEKISSVYELIFRTQMSEFQMSNMKQSQSQIQNNDPRNYFGLRDFYYFIKMIGFNFANNKIKYDDPYMIWNVIYRNFGSKPDFIGNLRPEIMKIFNFSSMPKPPSALSLMQQNLSLSIVDQKRFPDVKLPQSILNHPQKFSRHLMILPNRASILPLILSQIKRKYIVIFGSSFAEDKKALRIIQNLKKVERAVTEGKTIVLCYNEQLYEPLYDLLNQNYIQEDDRLFAPYETQFPPILNRFEKQLVLPEDFIVQKEFISFLTEQTTNLSNIKKYTKFRISNKNLIINYHEDLLSSLAVKLKDDNGVEEKIRKKYKKSKNIEKKVIEEKKKYGEKCWIRLCKTEKMIQLFDIISNEKLEESEKTFLQNIWNTFESQYCYNFSELFKKEISKYKIKNCAILTYSSYTNQKIDIPKEYKLEEIDLSNYTSDTELKRDLEDNWYNQINNSKFILGVHLNLAEKESLELFYQTKYLIESMIERNSSKIDNQHSIDESENRSYLLKTHNCYIVFFLHLPPKQTSNSFYYCFENDWEFYYLDELEQKYNFDLIKLKKENWDLKDILNNFQNNFKEFITQIFPVSISQFSDPLNPNYSQEFQELDKLLNTNDQLQKIIFNNILNMITEGNEKGLELYKWDITTIISSYNQNVSVSEYVFNIFIEKITRIFAILLNNLNRNENFRLIKENEIIRDIWFSIVSEYQIPFYDVFIPDQFKKAEFPFSFLIYSLIEDFGSVPKEKKYLRNIINIPFSKIKTFKSSNNDNENIDKKIIKDIVIRYFHDFLKISLGNQIEKIQEVQNHLINAIEGFNNQKIIDISLKRIHSTFSEKVKPHLQDILLLHKYYNLLITQDESSQRKNPKSKKKHFSIFSLLQNYFKALENTYKKGNLENKKYLCGIISESIPFVQNLMISLTNQSKKANEISSLSDHWSRVLILRNVFICFLVPFGKELSISSQTTSLLFLENNENNENNENNENTNIVDHFFNDIWGEIEKKFVSFKKDSVLKYIEMIGENPKKNKLKNICFCENNNHPILTNEIKQKKPYICSCCQKEYKSKSKHYEKATAEKISNYKQKLAKFANYSSFFLENFGKILFQQILIKFYLKEKLDQIKGNFVKYIDNLLKDTSRVTPSLFNSLIRDFVFPPIEDPELRDLFMDILNIFLNKVDLSEQNINNIFGASCLQILINQDSNEEIDQIEQIMDTSNINELLPKKKYTLRKIYRIANFRKLLIENTKNFVKKNQEFFQKKEGKKWIMFLFRFIYHEKGSAELSRFVAENLHFLRKNIKEVGDIISIDTNAFNCEVIIPNLKNEETLVKHFQNKIMGIPNKKEYKSKVSCLQFAFDFSDTIQNTIKDVGIIRLLFHTLEIVNSINFEPLVKLVSIEITRNSNDPTAKKMIDKLSSIYWPSMPEHPDLQSFKKKPKNWWICPNKHPFYIDGCGKPMYIYNCQTCGARIGGTHHQPIEGTVRATIENFPEYLGYSHSIFPIDESLNVRILSPISYLILKIMTISCVLSLATINDSFADNFSLIINPELEKPENKTQIIGNFLKIINKSISIMKNILKISIEDTFKYYHKVLNLLAKDEYSKHLRYEIDDLQTIENRNQIEEHFNQIIVKEHENIITQIKNEKSNEKEKKSALKHLEKEEVLWPYLYYKTQTYDEFLGLFHRDQANSRNFPIIHFVNENRENLEILRLFPQFIRFTSLIMQRFNGILSSNDIQDMKISHFIEKEKEKGNISNSIENLYQDFENFWNLTWKYVKQLLVCHETPEYLQKIVMNKDQSIGLCLTGDEDVYLCVPNLINHVIDLHNNLIRQESIQENIKQQILSNQKKKKKKKKKNNNNNNNNENDNNEIIEYEDEDEDEDEDKFDILHFPTQNYFDWSKLISIDINGIINFINDHQIDQISYEILEQYLIEKFNFSTKSKKIVSQIEFFSFKDKIDKKVYALQNLNWKQEKIPIEKWDRIVGELTVSKSIEQCKNLTKTVIFSCSNIPLDSVHLNNIPDLNLIEFAAEKLKLKKNDDLIATKEGSKIFTKEIQLKHLLDLYKKFEEHFTDLREKISDKFKEQINQNQKEDLDKIQDHFDIETLLIIWKRSLLKLNETASVSYLFKEYMSYIPYENDQEKQCISLLDKHFPKSISCSHSLSAFEYASNFKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9L7</accession>
    <name>A0A9Q0L9L7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adp-ribose glycohydrolase arh3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9L7"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF12">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="545" mass="63886" checksum="8478B81DC2E79BA0" modified="2023-09-13" version="1">MQKNNKSFWVEKVRRCLISGLVGDAVGALFENKSIDNISSKISQEKVYVYTDDTQMTLSICEHYLLNKNLDSPKLFDKWTEASENLFWIVNGYSPKKFQFGLFRGTGNMFRTAIRNKKPSKSAGNGASMRIAPVAIAAWRNTKNIDKAIQSLQNDLFQITNLTHTHFFAFTTAYAYAVLLLYFIGSPFKKKVTDSQININEALKFVYERVLEYEYLMKSPNQPELEDQSYFSAVSSFFKLIIVDNFFEKNKKESLFDLNVGNFIKNYAELYTTKKVDKPSDGFSLCSVLLSIMLALKYHNKKYEEALKKVLSFGGDTDTLATMTLTLITSINSNCYPDEKSYLLKKSIGYSNANEMFTVFGKFVANEPSDLVLKPWIDMEEELSKELINYKGSLGFTIIFDNQFNFLQFIDNELTQFFQKNSGLSIDQLYIQFYSQYQYLDFFKTLKSEERMNFFLNTYFQFQNTNLQSNQNYQQQQNYPQNNQNYQQQQNYQFDNKNNPYNQQQQNYQQQQNYQLDNKNNPYNQQQSNYPQNNQYKYNKKNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9N8</accession>
    <name>A0A9Q0L9N8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9N8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="491"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="69798" checksum="1991A280C115CCB8" modified="2023-09-13" version="1">MEKINHILFFGENTLSEKLLKRELYTRIIKPIQFKFENENENENENENENENEKQIKQISTGYFATIFLFENGKALEYLRFPHEKSNPQKIENIQKVTVGLENEAALTIEGNVFAKGKYINPKNPDEFINISSLIEDTNDRVIQDIVSGHNSIYLLTSNQNAYGIGSNEYCQLGFDSKTLEKTKKPILMMKNVFKIFSGNTSHHVFLLNSNQELFGCGWNFYGQLGLGESKPRKLTKIQNIPKGEIFDIQCGNNHSIMLIKDENYKRKLYSCGEYAYNGLGKKKHTYEFTEIKSSLFENDDNILEISCGNTHTLILTYNRKLIGFGWSNFGELGIKKKKSILKPIQIKLPKLRFNKDIFNYHISCGYNNSFLYYSSPSLSSFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLNENQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINYNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSDKSFQIFEYWIYSNQIKNEIKITQEIIDEIKIGIDYFQLNQTYPNLIDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAG0</accession>
    <name>A0A9Q0LAG0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAG0"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="226" mass="25882" checksum="3410DD5539244E38" modified="2023-09-13" version="1">MKTKSINTKLVEDSNPIINQFNQILQLLTGNSQLFYSNTNYLTAFQSSLNQIYQIIKQLKPISESFETNIQESISSIFKLINLIQLLIFKQSHIIIRTSIQKFSENFISLFKSSNQAITGFGEEQKQKFSIFAQEAHLSLKNIANLTQLKDSKSLNNIDELVLKPLTLLLSKIIPFYNYVKELSVSVSDLDSQLNLLSSLSNFNNQFQNFKSLIETLIKLFSNKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAG9</accession>
    <name>A0A9Q0LAG9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5068003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAG9"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="40601" checksum="D1D8F7749427B96F" modified="2023-09-13" version="1">MTNLIENIEEERFNNNDEEFNLKKFTKKLKELSENYEDYLSGKKTLKMNNNEVKYFGTQMYECAIIQPKKETQEIKPNKSSIIGSIVGYLNNILSLRIENSSDDSERNYNINLPDLFPKLKSLEIFQCDLNDFYDLHKFIPKLTHLTLDSCKMKNFKDVFLDGSLTNKIKSFTCTHNFINFFDESLKSLQEIENLDLHSNKITEITGMNYINIKNLNTLNLSFNQISSVSQIYMFLGYIKELNLSGNRLTSTKGLTKLYSLEKLDISENKITSIKEITALRKIPNLFDLKIALNPCTKREEHRAQTFLVLKSLIYLDNKTISKKEQEETENGRAKKNEAKTKGNGKNEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAQ9</accession>
    <name>A0A9Q0LAQ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5069010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAQ9"/>
    <dbReference type="OrthoDB" id="10689782at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="391"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="443"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="610"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="715" mass="82817" checksum="496C6E276C746AE4" modified="2023-09-13" version="1">MATDENNQILFFGLNKNAKLFSNEEDEITKPIEFKFENENENENENENENENKQEIKQISTGEFSTIFLFENGKAIEYLNFSNLNPQKIQIKENIQKVSVGSWNEAILTKEGEVFAKGRDIDPNNPNQLLRYSGFMNDDHSFLNISELPQDPNELIIIPGLNDENQIVDIPESKEDPNELIIIPGLNDENQIVDIPESKEDPNELINISELIEDQNKSADIRDLMENSNTDILISTVMEQTDEFMNISLLIEDANDKVIEDIVSGSNSIYLLTSNQNAYGVGSNFYGQLGFDSKTLETTEKPILMMKNVSKIFSGNSSIHVFLLNSNQELFGCGWNNSGQLGLGESRKEEETDKLIKIQNIPKGKIIDIQCGIDHSIMLIEDENENENPKRKLYSCGYYKINGLGKIEDTYEFTEIKSSLFENDNILDFSVGHDHTLILTSNQKLIGFGNNEYGQLGTGNREEQLTPIEIELPELRFNEDIPNYHISCGFNKSFLYYSPLYFSNLEEDLINLFRRKEFCNISFKTQNGEIIEAHKLILQTIIGQDENQIEKLQQIISKKSIQESNQIFEIIYSNNSKVNPKLYEEIEIEFNLFGSIEEKMKELIEFENEKDFIIQRKEKQYKFPKLILIMRSKLFRGMFLSNKDDKFNQFNYDSELSDEAFEILEYWIYSNQLKEEIEITQEIINEIKKGIDYFQLNQTHPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAT8</accession>
    <name>A0A9Q0LAT8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cerebellar degeneration-related antigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAT8"/>
    <dbReference type="OMA" id="HRHNRSH"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="165" mass="19024" checksum="93D731C00A6A6901" modified="2023-09-13" version="1">MKKKKKKKKKKKNPQEKQEAKQYQTKNKNKNKNKMKMKKKKKKKKRKRKQIKSKRIPKRNDDYNLNILNSNSHSEKGKKRKLKLKPKSKSKSKSKPKSKSKLKSNSKSKSKSRSESESDSDSDSNSDSNSNSDSNSNSNSDSDSDSDSDFKSRSNSNSETDSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAU0</accession>
    <name>A0A9Q0LAU0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_11771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAU0"/>
    <dbReference type="OMA" id="LTKYGCG"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="95"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="253"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5069286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="463" mass="51716" checksum="25ACAFECC08C14D4" modified="2023-09-13" version="1">MIYIVEFIVTAFRESPYHVITEIFFAVLLLVLLLQKAHNPTKEKPLTKKEEDELIAEWEPEPLSRPLNEEEKWELSTIPLIESKPGIMVTMNGKKTLNFGSYNFLGVVDLPEFTEAAKKEIYKYGVGTCGPRGFYGTLQIHLDLEQRLAKFMGTPEAILYAYGFATISSAIPTLAKRGDVIFCDEGVSFAVQTGVTLSRSKVYYFRHNDVDHLEEFLKLQDEIDQKYSCRLAIEESLSLGVLGKTERGICEYYNISRDAVECTTSSLGNAFSSVGGFCCGSAIVVKQQTLLGAGYCFSASLPALLCGSSLKVLDILEHNEKIEGPDNIFSKLKTLSLHFRAELAGIHGLEVAGDPSVPLVHLRLNSKTSQKNRHKNERILQEIVNKCFESEYPLGLTRAKYSEEEYLMPPPSIRICISASHSKEQLTKAAQVLKKVAESVFRDGISFDNELNSNEINSNNLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBN0</accession>
    <name>A0A9Q0LBN0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adp-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBN0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="515" mass="61229" checksum="627CB911AC052C9A" modified="2023-09-13" version="1">MTLSICEHYLLNKNLDLPKLFDKWTEASENLFWIVNGYSPKRFQFGLFRGTGNMFRTAIRNKTPSKSAGNGASMRIAPVAIAAWRNTKKINKAIQSLRNDLFQITNLTHTNFFAFTTAYAYAVLLLYFIGSPLDEKKTDSQININETLKFVYQRVLEYEECLMKSSNIPELEDQSYFSAVSSFFKAFIVDNFFEKNKKEKLFDFNVGNFIKNYAELYTTKKVDKPSDGFSLCSVLLSIMLALKYHNKKYEEALKKVLSFGGDTDTLATMTLTLITSINSNCYPDEKSSLLRKSIGYSNANDMFTVFGKFVANEPSDLVLKPWIDMEEELSKKLINYKGSLGFTIIFDRQFNFLQFLDNELTQFFQKNSGLSIDQLYIQFYSQYQYLDFFKTLKKEERMNFFLNTYFQFQNTNLQSNQNYQQQQNYQQQQNYQYNQQQQNYQYNQQQQNYQFDNKNNQYYQQQNYQYNQQQQNYPQNNQNFQQQNYQFDDKNNQYYQQQNYPQNNPYKYNKKNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBT4</accession>
    <name>A0A9Q0LBT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Macrolide-efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_11342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBT4"/>
    <dbReference type="OrthoDB" id="46230at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43266">
        <property type="entry name" value="MACROLIDE-EFFLUX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43266:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="441"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5069977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="639" mass="73690" checksum="9232A7C662282B1A" modified="2023-09-13" version="1">MQYIRLLKKNKPYFWLWLAFVISLFGDWFTNIAAIVIGTKIKNSQLVVSILFILEIAPSFLLIPITGPVIDYFNRNNVMIFCDFFRAGFVLFYILADKIGSLGFLFFVVAVQFSASAFFLPARIAVICDVVTKEEAVLADILDSLTYSSVYFIGAALGGISVEEGGIIISFIIDSITFILSAISIFVSLHHLKKIGKFHYNKVNEDEDEDEDEDDIVSKKISDNKNIEKDSEMNSKDDENEIELESQNEFENENELENENQNELENENENENENENENQNQNQNQNQNQNQNQNQNQNQNQNLNQNQNESENEFEIENQNENELENENQNQNQNQNQNQKNQNQNQNQNQNQNQNQNQNQNQNQNQNENQNQNQNQNQNENENESENEFEIEKETELKYPFQNSINEKLIQDPKKKKKKKKKKKEKVNFSDAIRYLRNHKSYIFMITLKLEQGVIWSSIFVMALLILKTKFPLEKNGAIIIGIYYATDALGVIFPPLIAKKFTGKGSQKSCWITLFVALCFLFLGSIIVFIANIYTSLPTFLISTFFIATGAGITWVYSNLLIQLNFPEKMVGRMVGIDIGLCSFAEAIGYLLAGLLVDTAKFGYSETFLIIIIFSFVMIIYRLIHLIWFLVKSKKQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBY6</accession>
    <name>A0A9Q0LBY6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBY6"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="703"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="820" mass="96425" checksum="726DC49400FD6D63" modified="2023-09-13" version="1">MNKHFEIKSLYDLSKQKLNDLLVKEFSIYQEFITQSQKTKPDFKILCGKNKTQIDCHEFVLRLRAPFLFWKKTNISEKKQIDFPEFEFELVNFIINFLYTGIIEFEKANIPFDILWKFVDKIGLKTLQIRIEKEIEEIIDEENVIKYYLLSKSLDSNFISFVCENIIIQNIEKLLQQNEFGKLNEEEIIQMVSMIESRNETDKIQIILKIIENWGKSNQNQNQNQNQNQNEQNSERNFAKQVLLDVLEQIQQSKQISKSQFENIQENPFLPLGILVQIFNFKVKELNKLINEKEKYFQKRENFIQSQIRQIHQENINIKPDKKQAKHFFLNFHQKMETDSQKNFQNNNEELEQVKKWMYQFPNEEDIQENGTFYLRIFAGSNKRSEFEYRKKKGIQIAKSNGIEIIINATKNFPKNEIIQLNAIWSFINIAIEGENKNQISEFKGIEMIINAMNNFQDNPNIQEKSFRALINLCSGSEKNQNEISKLNGIETIIKSLTKFSDNEVIQLFGLWILGVLSQNVESKLEISFLKGTEEIIKSMRKFSLNPELQEKGCALLSNLGLIETNQNDIGNFHGMEVIINAMNNFPDIKNIQVYGCSALNNLVVKWENKDNIRDLKGIKPIINAMKKFPSDEQIQMYGCWTLNNICESFENQAEIRNLGGIPLIIDRMNKFPNVYQIQKQGTWILNKFSMKKENLIEIKEYDGLKSIIQSMKTFENDESFQKISCWALDNLSLDHENQKTIRELKGIKLIKKAMINFPDKKEIQQECCFCFLNLISNQTNIPLLKELQLEDLIEKAMINFPNEGDIQENGKWFLEIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC27</accession>
    <name>A0A9Q0LC27_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC27"/>
    <dbReference type="OrthoDB" id="10252328at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="390"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="531" mass="60013" checksum="181B6E4B5AFD0CCE" modified="2023-09-13" version="1">MQTLREAIILGDLYRIQRILQQKLNLVDFGADKSALHFACGVQNISPIILRELIFAGSDVNVKNKEIPLHILCKNKPKAEAIHLLITLGSNPNAKNKKTCLHQACMSFASLEGIQALIEDGADCTMIDSNSPLHEACKNGCDLAIIQLLVDNGADVNLKNRYTPLHFAAQAGTSPGTVDYLISKGAKVTPKTFQRAIHLAINSNANSQLIHSLITAGCPLDSHKSIHALKLACQKNLPVDSLRILYLATQDKRLKSNSLKLIRDITKVNQIKEYSPLGEDILELFTDQEYTDMEIECSNGSIRCHALILNARIGENNMKKALEIFKKRPRSSVTLFMNYIYGGIITTSSFREVTDIAKSIGISTPSHDSKINQKSLLKTFRKLYSQNSSKDFEIIVDKKSIKVHKLILLARSDYFEQLIQDSEENVKSVKDGSNKSYSVVQKVIKSFYFDEFNDLPQKEFQDLRNVVDFYQPNQNSIPLQLAKNQREVILKAKNAEKFIWKEFISSVIFLWIVYLIIKWAFYKISSHFQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC55</accession>
    <name>A0A9Q0LC55_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_11201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC55"/>
    <dbReference type="OMA" id="RQIWDAI"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="374"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="718"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5070172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="748" mass="84980" checksum="91EE7CB76CB5B250" modified="2023-09-13" version="1">MTSKKNLVVYQPFSSIVEPIFWSTLTKTKLNEWKLDNSEKTIFGTYRAKYEPDFPTQFWLNMNSFEYADYSQKEYKHLAPFSFMAPGTILNTNTMKEYKNLDKIQLFKNTANLIWQDIVNGEALEDTSRLGRFLLLTYADLKKYIFYYWFAFPALILKSKNGDLISHKEPPVMIDKFFSEKQIEALYGSLLRLREPDLESDEDKISTGKTGNLNVFLIKKTKEKEEDAISVGKLSEWNTFWGKEKEENKKEESEDIEYIVGFIDPSGVSFVPGWPLRNILALISVRFAVSRLKVVCIREDPSNSDIKNSFVLDLQVPVVEDVSGKNLKEGQECVFESSGWEKNTKGKLAPRLVDLSGLMSPEKLAESAVNLNLQLMRWRLLPELDLEIISRTKCLLIGAGTLGCVVGRALLGWGFRHITFVDGGRVSYSNPVRQWLYTFEDSHVSNGRYKATVAGEQLSRIFPSVKSSGHVIMIPMPGHVVTSREIEATKKSVEEIENLIKDHDVVFLMTDTRESRWLPSMLCAYHGKPVIDIALGFANYFVMRHGVPEGESDGGVHPKSPMTHACYFCQDVVAPIDSISDRTLDMQCTVTRPALSPIAGSLGVELLVSILHHPQKWFALSDTKESPQEVKSPLGYVPHQIRGYLSSFDNFLVSSSPFSKCVACSSIVRNAYHEGGFDFLLKVFNEPSFLENLTGLDLLHKNVEKMLENYVNEMTIHEENLKEKDQSKNNENIDSKKDDDDDDDFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCV0</accession>
    <name>A0A9Q0LCV0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lissencephaly-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCV0"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="85" mass="9632" checksum="478F5B73F33E5E8C" modified="2023-09-13" version="1">MDKNKKQKQIFIPTSPAKIILKGHKSPIMAVKYHPVFSLVATVSEDATTKIWDIESGEMIESVKGHTNIVQDIDWNEDGKFFSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDL5</accession>
    <name>A0A9Q0LDL5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_01918</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDL5"/>
    <dbReference type="OMA" id="KFYVRFK"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="146"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="14">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5070937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="197" mass="22672" checksum="A3FA6EF87E323102" modified="2023-09-13" version="1">MTSESIKRKQKDVMKLISKGFQPELENENDISTFYVNLNGPKESPYEGGIWKIRVHLPEGYPYKSPSIGFMNKIYHPNIDFASGTVCLDVINQTWTPIFDLENIFDIFLPQLLLYPNPNDPLNHEAASLLKQNRIQFNKIAKEFTEKYANPKNDKESNSKKKKNDQKSDSISDISDISDLSNLDDNDNDNENDSFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDQ0</accession>
    <name>A0A9Q0LDQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDQ0"/>
    <dbReference type="OMA" id="MRAANKP"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="22587" checksum="3B4A5C1F0D35E9C4" modified="2023-09-13" version="1">MENNKSFDYELRIGIFGAGGVGKSTITIKFTHNIFIEEYDPTIEDEYIKEIELNDKKILLKVLDTAYPEEFCDPFPRWVEFSQVFVLVYSIIDKYSFGEILNYHYKRIKNILNVQDYPKILIGNKSDLFTKREVKTKKGKELAKQLNCKYIETSAKTGENLNQLFYEASLLAIQELKNKENQNKKKKGKCLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE06</accession>
    <name>A0A9Q0LE06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE06"/>
    <dbReference type="OMA" id="WISHHEI"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="352" mass="41341" checksum="7645938F1AEA82EF" modified="2023-09-13" version="1">MSLQNALKSVQLKKQTQQNSTENNLNGFFTEQELRDGQKQVLEVNIENWIELLESKNLTFPTKFVSISIQEAKSLKECCEQQKKYGKIEENKLSELNDLKKKLNQEIKDLLSNSKFNQDGIFMKMSSRSAKDAIEFHPNFPIFYKNQLLDLKKPFKDISENEKLFALIEASKNCLKVKNADDIIFLVTHSDRIWMDMSIALENIDIFNESFVLRTWFDIDADLEFRGYVFNNNLNALSQYFQYFSSPRLVEQKEEIQKIILNFFENEVKPCLSTKFTNYVIDFCIAKEPKNQPFVIELNAFHFSDTCLFNWAKDQELFKNGPFEFRITEKPRSGAKAELEKSWKELIETVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEF2</accession>
    <name>A0A9Q0LEF2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small rab-related gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEF2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="265" mass="30824" checksum="59BDC8C9BF93DA70" modified="2023-09-13" version="1">MNNFPTNEIIQENSCFALRKFTETNKKKSIQFENLNGIDLILKTMINFPNNQQIQFQSFSIFINIGKEKENQNKIKELFGIEIIILSIIKFEKDKNLKKQGFKALSNLGLKNKEIQNQIKTKKELKIEDFRKIEKKDVPKDSDYILLKIILLGGDNIGKTQIVNRFVNNSFRVDSAPTIGIDYEEIFLEVNGKIIILQIWDTPSQERKVSKEEAQKFADKIGIPFIETSAKENINIDEAFFLLIKMILQNPNFYEKLLNSKLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFJ5</accession>
    <name>A0A9Q0LFJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFJ5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="109" mass="12985" checksum="10A6AFD11EB72C4E" modified="2023-09-13" version="1">MSNFKIDKLISSILNQINQIQSQIENVSQENLSQKEKVQLTYLMNLLFEIYVLSHGVEEPSDLQIELKRIKENLLKFEEENIKENIKENIKENIKENIKENIKENIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG54</accession>
    <name>A0A9Q0LG54_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG54"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="271"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="494"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="615" mass="71649" checksum="3A4B6DD16C3FB7DA" modified="2023-09-13" version="1">MNEILFFGSNQKPKLFKNETNKITKPIQFKFENENENENVKQNQNENEKQIKQISSGLFSTIFLFKNGKAIEYLKDSNQNPQKIQIENIQKVTVSYQNEAILTIEGNVFAKGIDINPNNLKEFINISSLIKDKNDRIIQDIVSGYSSIYLLTSNQNVYGIGSNKLAQLGFDSETLPKTEKPILIMKNVSKIFSGNSSVNVFLLNSNQELFGCGLNEYGQLGLGESRRRETKIQKLTKIKNIPKGKIIYIQSGNFHSIMLIENENENENPKRKLYSCGRSQYNGLGKPKITYEFTEIKSSLFENDDILDISVGDKHTLILTSNSKLIGFGYNNFGELGTGDTYWNQSIPIQIELPKLRFNENISNYHISCGDFSSFLYYSTPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNENQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIEEIKIGIDYFQLNQTNPNLFDLLINKFNNQNLIQNSNQKKKENCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGV2</accession>
    <name>A0A9Q0LGV2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron carrier/ protein disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGV2"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="444"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="848" mass="99519" checksum="0EBA5F201480F2AE" modified="2023-09-13" version="1">MGNANQVKSVIEKKKISSYKQMISSSDKTLFVATSKGKLIEFSQPTIELFAASTRKEMSKTKFVHIVPKVQKIPEIQSKNKMKLIIENALKSEKGFTDDDFQWKDLRGKLFWTHIWITPLSLDGNFRIQCLIEKISKPLAMIEKEKEEEQARLSKEAKEEKQRLKKELESLKKSIKQLKFEKNKLTAQMDHRGSLEMRLQAMKERLENIQKESSSLIHEIDQANKSVKNHPINQEAKIQELRLLKKKLKFENQKLYSQQTTSDLLKNVRNVRDKIKLSEDETNNIQKEFIQKQEKLKDLQEALHTKAVEEKISLFQKKLLKKQTQIEKEKYEISNLTSFLRSQKIAAQQQLDSMKMQIKEKKNENKNLQKEVDALSKELTLAESDYELSQNISNNSDSIVQSDPISINELADKKLKRSNTVPAKFQNNTPTRDPFIKSNFNQTNIFEVLREPVGVMHFQDYLSHQFEVENLMICIAISEFKTITDEKMRRKKSEEIYKKFIKKDSIFEIFLENEERENLRQMILNGVASSDMFDEVQQIILKHLSDESLPNFMNTIYFQSFYRDMQTKTVVKMPHQALLVHQVNRSNSLNMSFNISQTIQYKYPFQVALELIKSLIDILASNFSIRTQQVDLNTLSQSIPFRRFANATSELQNIKLSDLEKNQIIPFFVNIYNLLYLHGAILNGVPLDKAMENKFFHETTYIIDHHVFSLNDILHGILRCNKPQPKSNEKVFSSHDKRLFIVPEQFDSRVHFALTDLDQESPPIRVFYPHNFSQFLEQHTKAYLTTYFRISNKTKRVLLPKMFGVFPSDFGENHSQIIQYISHFLDDKKLLKLFKINQQFIFKINIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGZ7</accession>
    <name>A0A9Q0LGZ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGZ7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="726"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="737"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="922" mass="107540" checksum="B340E4596B1947AE" modified="2023-09-13" version="1">MIVFDFGTSNFRAGIAGEKKPLIQIPPFLEKKTTQTNFANSKTRIIGENARNQTNQLNIATPLNKGVINNWESFQDLVEYMIVSKLNYNPKDVFGFFSEPPNNPNANREKTTQIAIETLGLSGVYLAPQPVLSLFPLEKITGLVVDIGENLSYTVPVIEGYVFESALQLIPVSGEQLTYYLIKSIEEKGTKFPTLNRFNIAEDIKKKLSYISLDYRQEITSSFYYSSNQKEYELNDDNVIYLQAERFLCPEPLFQPKLLGINHPGLVQSIEKSIETITNPQNAKDLCENLILVGGSTLFKNFSERIQKDIFESKPEKSVKIIADPDRSNLVWRGGSILASTPGFGEMFISPREYQEEGSRIVLRKCDFFYFGTELKKDSTVKESYEEPQQAYYEEPQEEYYYDEYYQQQQQGYYDQNQNYEQDQYYEQDQYYEQQQQQDQYYEQQQDQYYEQDQQQTIKQQDQQQTIKQQDQQQTIKQQDQQQTIKQNDNIQNQTKQDNIIQNQTIKQNDIIQNQTKQDNIIQNQTKQNDIIQNQTKQKDIIQNQTIQNDNIQNQDTNLQTQFEEDQKTQDVQEEPVIEEDQGPDFETRMEELDKQSDDKLKMIQIKNEENQKLESQLKELQKIQKRLKGEIKTLTDKLTRIQSSGDIQVKQSRILNECRKEMKQKYEMSMKEQGIYDKEQEIKAKYEKLEKETQDFLKEKQDFLFEQQRFFGSLGFEPDLKLLNIREGTKGKRRSPTTTTTTTTSKSKSKSPTTTSTTKSKSPTKPKSTSPTKQKEIYTWNKDSKSTQKTTSTQKDSSKQTQKKTTQEIKKTTTHSYWEPKKTPTPPQNTDVPKNPVAPKNQVAPKKPIALSGPHPPLESPPKTPKEEEKKSSFVNRWKAFEKANEQKKPTRTQRKRTTPIQKPQENTTNQEQQNQQGKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH99</accession>
    <name>A0A9Q0LH99_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase ii subunit rpb11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH99"/>
    <dbReference type="OMA" id="MNAPSRY"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="120" mass="13767" checksum="38C4BCE023A20F35" modified="2023-09-13" version="1">MIRLPEHTVNLPEPFESFLLPEGTKKITIEPDERTPNSVTCIIEKETHTIGNLLRMKLLEDPNVLFAGYKVPHPLEHKVVLRVQTQNSDPTTAIKQSLDSLIKDCDLLEKQFKEKTKHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI64</accession>
    <name>A0A9Q0LI64_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI64"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10354" checksum="B9F3A85A921326C1" modified="2023-09-13" version="1">MRSELYRGMFLSVTKDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITKEIIEEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIN4</accession>
    <name>A0A9Q0LIN4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIN4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="406" mass="48785" checksum="58752AFA92461EE4" modified="2023-09-13" version="1">MFNERKHSNKKPSFLHEFEFKRQAINKKMIKTRNESPKSDINFFTQMNIPEKPEKPEKPEKRKEKEKILINPIRNEFKNTFYKQNSHQFKNSFEKQNSKIKIYQEKLNSTEKNQNNQKSLQTSKLHSSADNFNRNITNPFNTDINSRNNPDSSNLNTNFRDQQIQSNNNDENHFIWRYDQSLNENTRNSFQNQEGLFSRNISYSNNIIHNQNSNQILKDDSQDLNINQQNYSKRYQRFSENIDLPQNSVRKENTYFSFGVINNIKVLKNDSPSLTSYANSVNFLNTNTQSNQVEVDSSDSPYWIPKQRNNRIVFENQFQNQTNQFQNQTNQFQNQTNQFQNQTNQFQNQTNQFQNQTNQFQNNTNQFQNQFQNQFQNHFQNQFQNNINQFQNDENDQIMKIEKDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJJ0</accession>
    <name>A0A9Q0LJJ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJJ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="372" mass="44913" checksum="4960C85BB72BA54C" modified="2023-09-13" version="1">MKQKEKLIISKKDYFFILIYSKIQMKIHLLIHILSNQQNYSNSKIYQNIYPQVQMYVLFELKRMIINDVEIKEILNFFKNGDLQTLLIDLMINVLTFQDYFGYKFLFNQIFKNQNIKSNLSLLKIKAFEGIEEILFHSIQKQNKSIELCLKILDLLFQKADIEIILQNQELTISLIKLFKNKITQKISLTHIPKILEKQKFKWRKGESIHLFLFQNFIFNSRNQFKNKIKTKNQMKFNDIEELFQNVQNQFQKPRKKEKPTEKLLQILFDLMISNGKFFIRGIILLSETKYDKYYFGTLLPKSKGKMKKNLIKKQKPKSYLSNLFKSRKSNYWNQDFHLSKMVFFFFTQKYKIKLELEITIYIDGNQQKTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKB3</accession>
    <name>A0A9Q0LKB3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKB3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="169" mass="18908" checksum="B5944EA12840E679" modified="2023-09-13" version="1">MDMTICPTIDGYAKKPSKFLHILWLILNICFLAISICFIITGAYWKGKDNEEKCTSTKLSQYLISGGSIFLAFSLTMFHNFFSSCFMTEIDAWGDGEQDSFFCIRTLICQLIFGIANFVLAILSILIIKSDLKGCSNSLYVFGIIYSVLGLTVLGGFCLYFPIASVFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKD8</accession>
    <name>A0A9Q0LKD8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Huntingtin interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKD8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="288" mass="33610" checksum="D4CB950F1E9B9B1F" modified="2023-09-13" version="1">MINSVNRFLSELLSQNSQLENELQQKKSQFLKLETKNKKQEEELSKLVSQDSSQTTKDLIAETKEIEENYQKSQKQISKLEEEIEKMNLQNKTLSEDLEKKSQLYSQLQKENSSIEDFFEMNEKLQSQISTEKQLSLLNAQKIKEKTEKKQKIENQVEEIQKKIQQVKEQLEQKNLQEKENLKNVLQLFDELVIQEDSLTSKLTNFHHHQLTLKQIEMLLVKKSQIDKLDKSESSSLGSLIAEINRLKGENVVSSLENGSFLENKNSIDQIKSSISKIQQEINQNLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKN9</accession>
    <name>A0A9Q0LKN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKN9"/>
    <dbReference type="OMA" id="NDLEQNF"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="348" mass="41598" checksum="7897EB94157D567C" modified="2023-09-13" version="1">MSDSNQIIEAQINNLSLQILKYHSLFQNFKKKHSEKFISYESLGGFFDTEIKLKDFGIEELQNEHTKNLQILEQKQKDLDLSTQKRSEFEETIKALQSINEPEKQKEYLQNIFQALEEEEQDLKEKVNQVRMQKEQMELENNQQKELNQQEIDLLVLSKKQNEEMIKETTEQIQQVIEERKQLKEKMNETSKKENQERTEEEKQMLENLEKEMEELKKKNHSLNFKLFDLKKQFNDLEQNFDDLTNENSDLQFKRQECEKDLQKAREMEKSFHIIKSELVEMKKEYQKKIKENEELNKKIIENSGLIEKTPIVTGNPNTTLYVGFPTLIIGTFLVVKTFKLITFNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKQ0</accession>
    <name>A0A9Q0LKQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKQ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="17958" checksum="1E42C76730BDE866" modified="2023-09-13" version="1">MIYSNRIINPILHSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKW7</accession>
    <name>A0A9Q0LKW7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKW7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="202"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="84"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="434"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1137" mass="134898" checksum="E874E6D7F8B0E232" modified="2023-09-13" version="1">MGANESKLNLNQNQNQNQNQNPNPNQIQIQIQIPEQFIQIPEQFIQMQKQIQQLLQIQNQNLNQNQNQNQNQNQIQIQNPFQNLNQNQNQNQNLNQIQNQNQNQNQNQYQNQNQNPFQNQNQYQNQNLNQIQNQIQNQIQNQNQNQIQNQIQNLNQNQNQYQNQNQIQNQNQIQSKIKKFNKFLIKQANKQIGLMFENEETSDFQIYCGKDKISIPCHKSILEARSKYFMINRRESKFNSIYFNNFSSEIVKPIIKFFYNGKFKFDKRKFDEYFKFANEIKLKEIQFKIELEIQSIFNIQNILEIYFKSQEINSKNLSQNCEKFIFQNIQFIISNPNFDKYLNQNQIYNFIGLISLNQNLPNQLQIIQQIKQKWNQNKQKKLINFINFETNQKENENENEINENENYFSTLLNQISQTKSINQFQIQQIKNKSISQLQNKMDLFNLNIEEFKEKEFQPLQKNKILLYFQIADKQKENRKLEKLKKQIQEIQEKFQRLIQNDEKIKKEYLQEFNKRIINLKDLFNQNRKDDLENFQKEIQEIKNQFQTGEIQDFQEINSKLQELITDFKSTTEQELKSFEEITQQFKNEFEKKREEKFEEFKQFIQKSKNEFEYPYFEQIEKKIQEMEIKNENLNEIEKLIQEFKIEIEKAKNEFYLQIDQKMKNIQNEIENQKLKIEILQSSKKTKKFLQELSNKIQQQNERKTKELIEIDISFIIECMKKFNSHQHIQKNGCFILQQFAKENEENQIEIKKLKGIEPIINAMINFPINEEIQQFGCRALGNIADNNNKKNQNEIRKLKGIESIINAMNKFPNNEEIQHFGCGALGNIADNNNKENQIEIKKLKGIEPIIKAMINFPDNQEIQQFGCGALGIIANSKENQNEFRNLKGIEPIINAMINFPNNQDIQFNGCRVLGFISIQNQENKIEIRNLKGIEPIIKAMNNFPNNQDIQKFGCGAFLNISDENKENRIEIKNLKGIEPIINAMNNFPNNQEIQHFGCGALGIIANNKENKIEIRKLKGIEPIIKAMNNFPNNEDIQQYGCLALSLISIQNQKNQNEIKNLKGIEPIIKAMNNFPNNQEIQQFGCGALGIIANNKENQIEIKNLKGIEPIIKAMINFSDNQIIQQYGKLTLEKLQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL46</accession>
    <name>A0A9Q0LL46_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL46"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="210" mass="25361" checksum="19506188381EAE4E" modified="2023-09-13" version="1">MNKLLNSNDNFSDYQIQTNDFSKISIHKLILLTRFNNDKTIFQKFINICKLKPKREIFKQKENKITEFLKEIGIESNWIKQKKGRKGIIKDLTKLYEEETTKDFTIIVSEKEIKVHKLILIIRSELFKGMFLSVQDSSNQVHDYSRKSFETIQQLIYFLYHDKFYKERKGNNHQNNNQNYNNNIEEFKDLKDFYQLNQNSIIDLFLKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLF7</accession>
    <name>A0A9Q0LLF7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLF7"/>
    <dbReference type="OMA" id="LWFTPCK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="151" mass="15368" checksum="28E73823E52C5BAF" modified="2023-09-13" version="1">MFTFFHSCSPSNSPSNSPSNSPSCSPSWSPSHSCSPSNSPSCSPSCSPSWSPSHSCSPSNSPSNSPSNSPSNSPSWSPSHSCSPSCSPSTLPSNSPSCSPSWSPSHSCSPSNSPSCSPSWSPSHSCSPSNSPSCSPSVIQFSASPFVTFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLY4</accession>
    <name>A0A9Q0LLY4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleolar-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLY4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="495"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="791" mass="91704" checksum="0950AEC2B1EE861E" modified="2023-09-13" version="1">MEKQTKTCKCEDCKCEDCDCTMKDGICTCKCKTGKKRVKHLFTFAIVSVQNLPFQNNLLSIKCSRGKRIKTTKRNQINQSGSVKFEEEFSMPLTLFYKKNSENPDDKLFGLSFYFSKSLKAEEVLIAKLALNLSKINQLPQPVTEKFSVELSENLHSPQKPTITLSIMITKSSKEKKIQKEISLLSLIPVQEKLDKLNQEEKNSQKTMPKDKYYVSPLNSTTSGDENNEFPIKVENTELKDFAQNKTISSPNLSPAPIRRTVTEFSIEDGINPVTGERSVSPVKHLKKSTTEYFDQFLHNTNLFDYSPNIPKHKTSLYEIKNTNWKPEEESFYSPRKDNSNKNNLVDLEYKIVSSENSENSNKNNNHNSSESEINSTDFTDKIESSMESANELEAPSESEIENQKKIISDLKNQLESIESKIKISTIIAQQRKLLLELIHFTEPLYQNKYPVSALLLVKAEIYWGVFKQDENGEIFTSFLDILNLFIQNNRQEKERLVWLLSNCCFMIYLSNNFVIENGNSKPNHNFSKELTIIILTIFDNLNSVFMSELIPRLRKVISRKQRQPQQQTQFHKKEIKTSGGMCHTNLTQFFTNLYELMKKNFLPEQILIDIFQQVCSSAFNFLSQELNNNKNRCTSTIGLQIKMDFSLVDQWFCSWGLSDKINQFSKIKQLADCLILNKIIASDFENGYSVCQQIVPQIGWKQIYKILTNFQPDNLDPETIPQIQLENFREFHTNNTKSNLQSNESEFVLNENLFQNLTYNINSFEINYPQICSKYEFLFLKKSFKELQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNQ4</accession>
    <name>A0A9Q0LNQ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNQ4"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="261"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="373"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="795"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="841"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1012" mass="118620" checksum="36AAA7A41D9E2C95" modified="2023-09-13" version="1">MYCIAFVLEILFSSKENAIEKRENHENTDIEIDLDQQEKQAKLVCLLEFIRTIFDTHYLTISSMFKQEENKKKFKIQKYKFQLLKIPINQILDVLQGDEWSGFVSEIFEAKKVLDTKIKVSVMQFEDAMLMEMRIQSPIISQEKDEIATHKTRFKEEIKKTIEFQMKKNLEQNILRKKKRIVSQLKSAIQWKKLSRKLNHQQAHWSKLKSVFRDSDFRSQTKKEEKNEEKDLFQLYLDFNDFTIIPSIDNLNRFSDFRDLVNPKNILFSEPCFIRDFMKNIPGVFQIKSEKICFFIETTKNWELDLKNPKKIKKQWGINSIAKIRQMKFNFQPTAIEILFLNRKSYFFNFPTKEIANSAFENLKNLNLINLTEEEWNLGNFQQLTTKWQNFEVSNFEYLMRLNYLAGRTFNDLSQYPVFPWILSNYESKSINLSDPKNYRDLSKPIGALNSDRLEKVVKRFNDMSTKDALFPPFHYGSLYSSSGIALYYLVRLEPFTKMSYELHNQTFDHPDRIFFSINSAWKSVLTNFSDIRELIPEFFYFPEFLENREKIDFGKQFTGDTISEVILPLWSRNSDTFIQKHMQAFESEHVSSNFHNWIDLIFGYKQRGKQAKNAHNVFFHLSYEKNNDLSSQEEKETINKHVENFGQIPRQLFTDPHPAKKIIKESPLISKISPKNILDNIVICQLQISEHPISHLLLLHTSKDSVPDTSFDKLISIDSRKHLRNHKWNIHKFDFETISLQKSPKKFGSEFFELGFFHSSLYSVNSNSLIFSCGYSDFSFRVHSSEFLGFLGAFIKHKDIVTCIACTDTIFVTGSRDTTVVVWDILSSKKPIQIQQRYQLTDHKYEVNCVAINQEYDMLVTGSEGGSVLIYSLNSGRFFCSLDLKNLNEKTSKILQVRINNNGGIIVFSSNIISSIFSTSYTFSFYSINARFLGSISFGYPITSWDVSFNNLYLVVGCENEKMEIFDLQNYKRVKSFKITSRCSSVCITNDGKYLLVGCENGMLLFIQSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPF5</accession>
    <name>A0A9Q0LPF5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuralized-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPF5"/>
    <dbReference type="OrthoDB" id="49113at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="683" mass="80402" checksum="4C32772C57E4D70E" modified="2023-09-13" version="1">MFQRFKPPQPNRNQNRDRRRSIQNNQNQNNQIRKQDFGFQEVQFFDSLYSSWETYYGFENAQITLYIQRSEMKIECKTETQQNPLNFTIKSGTTHELNGIRYSGQPSYVEWNDGNDKFRIKFHDYFYAKSLDDEIEHLGNQRRRQTIEMSQIDITRMILIDSMKGRYLLNGKEKIAQARILGENLIITILHVAQQTKFTFTGDQMIEIADNHISFEDGTHFNFSEKNEDFKISVRNSCSKQSEENETKNMTIEFLKVGCDYNDFELEEQFEMDSFHIYSEKDVGFTINETNYFPPIGWIRLKMRNQGNKDVSKWSYGYHGTKHQNTKSIVQNGLVIPGNKTQDGTIVEIVKGHIPNQKHIYASQSYLYASHPIYALPVLFEYNDKTYYVRVMFQIRVDKVNITQEQTIGWPDNVPLDTQVPNDSLEWIIFSSDQIVPYGLLIKFDEENPDEIFQKIKENRLEKHNWSHRTTVKETEENINLNKEAPKEQKKKILWVDDEPENNEGIIEVARKVGLEITTVIDTNTAILKYQRNPAKWFLIISDMRRFEVRSGHPNEKREYITAGLTLTELIRKINKDVPIWIYSQYTRAHPHYHSICFHKGVSEVVNVSRILTHFFPYDPIYQSNDYPSVQGLEDFQDSSNEFLDVEYGQIFKVIIPFENSCFVADNDNKTTGFVLNKLIQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPH5</accession>
    <name>A0A9Q0LPH5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPH5"/>
    <dbReference type="OrthoDB" id="10624519at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="180" mass="21594" checksum="798490B832577819" modified="2023-09-13" version="1">MIDPSIFLTLGSFFQCWGNIFHPFETSLFAEKNEMNIEKKNEETKISMRTFSNRMETEKQKETPKKFMLSYRSQQFRARQKQKINDLKSRIKELKTQKENQRIREFQLRTEILLIEQQINFFQQFVSQAISLASRTGANNFLRNDSAFIPHENENQNENENQNENQNENENENENENKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPU6</accession>
    <name>A0A9Q0LPU6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPU6"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="281" mass="32749" checksum="0E216AC30D4A5959" modified="2023-09-13" version="1">MTFDFLFKVVLVGAAGVGKTNLIDRYVDGMFEAFRPRNIGVDFISKDLEIDNKKVRLQIWDTSGSKAYRIPFTSSIYKNTGCFIIVFDLTVEGTLKEVDDFIEEIEYNFRTEPLIVIVGNKCDLIEDQIENIEEKIKEILKGKEFKFVKTSAKDGTNVNELFEFIAKKLKENQPKIEQDNSQIIILEDAEDSNDTNKSKPRRGFQFRNPFRSKKKEKEKEKEKEKEKEKEKEKEKLKEKLKEKETNITILENGDLKITTSSNSHNLTFKFKPPVFSLYKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQG4</accession>
    <name>A0A9Q0LQG4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beach domain-containing protein lvsb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQG4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="144" mass="17003" checksum="C074DCB371F0F18F" modified="2023-09-13" version="1">MSVLWKTWDQTLNFTSFWESKLFKNIPFDEVIKCCHCTKRWKIFNIGRKLKMKKTLYGHTDSILSIDSSCEHRINCNRKFYYLKMKLLLLQFFSSGISGIYHNVIFTGMKSGSIEIWDSLDLTHISSITTFDSKYPITAFINEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQI6</accession>
    <name>A0A9Q0LQI6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQI6"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="36"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="696"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1076"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1181" mass="137671" checksum="705EAA3F064CF5FF" modified="2023-09-13" version="1">MSKTIPIEIRTLLYRIAFHAQTSNLKTSPTEQITRVDPLEILKRWVNYHVSQKINNNITNFTTDFEDLNVISILLESLSGEDFSILINNDNLQTKEQIFNDLLKQINYTDFFCSIDDFLNGREELIIKFLAKLFIWNPGFDQKKTTTTTTTTTSIPKTITTSIPKTTTISTSPNLNQSTVTSKPKLSTDVNQFLARLKSKKSPNLSSILANKFTMPKVTQEEKEEIEKEEKEEIEKEEIREEIKETEDIESEKITNQEDEIEDEIEYKNQFKNQFRNQKQEERNLPNFRELLQKSKEQGFKLDIKSSIEGDDSVLKPAPFNLPQNIQDLINKEKKQIIKTRKIIKKAKMLNTEKNYDHIQTIIDKTNLQINELFVVKEPKIFKKKQTKVSANITDELDPKDQETFSKMSTSIKEIKQTMQSYFENISSIFLGIDDVFPKFNEAILKVSDHIQTIKEIGSNKDNQNQTKSHYYFITQFLSVLREQNVPNMTKQIKNQISELIYGMDILENNYFNKWKEIIDLLTQKNVIPSPSSDNLILNQLYSKFNRFIYFQLIKKHIVEFLLQKLDVENHLRLFKPEILRRFDNILFGSFDINLFVEPLLLLFSHFPEQKMDLYSINLFIQEVKKKSFGDTLKLILNNLVPKEIRDSIEKVIKDPNNTELKRVFEKGKEIIKDLLPDEEIYFLTALFDKANNQELVKNISGAIFYFFDDFNESLNLIKMMIPQEVARTVSAGTLLKTDFTGEFVNLYSRQNGKSYIKKTIAKLVDDFCKSDLSLDVDPSDSQFEGDAQQNISNFQSQLDLFANAILTSASSAPLSFKLFATLIKQNLIVRFPDHYISVICTFILLRYFCEALKNPKQFELINSKRGLENIAFAFEKLAIGSTFGANLNQYAPLNTSMIKLFSGRSKFINEISSLNINSFDENDIKKEMENAKLYSQKNSFQGKKEPKYEINLEELEYPFLMIGSLLFIKKNIPFSLMTRLGTYQIEKNHREIYELNQEMLQINEYLDDLEILLNNYKDESKSVEKQLILNESTNQNENQNQNENQEEQKQKEVIDYSEMSDSELKEVWGNLSDIEATKEGNVYFSKTGGTFSWKKRYLVLKKNILAIFSSQSSYKDSRPKETIVVKSSYLIGFSKKVTYRKKSTFQITIPNRSHPLSFAFDHLTECEDWIHKLRSIRKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQV7</accession>
    <name>A0A9Q0LQV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQV7"/>
    <dbReference type="OMA" id="DESSKHY"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="337"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="503"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="608" mass="71204" checksum="71DBFEDC1D1F8FEF" modified="2023-09-13" version="1">MNDCLFFGLNQSPKILPNKSDKIIKPIQFKFENENKNENENENENEKQIKQISTGYFSTIFLFENGKAIEYLNERDSNQKPQKIQIEENIQKVFVGYQNEAILTKEGNVFAKGKDINPKNPKEFINISSLIEDTNDIIIKDIVYGYQSIYLLTSNQNVYGIGSNKFGQLSLSSKIIIKKHKNLNRKIRKTQKPILIMKNVSKVFSGASSEHVFLLNSNQELFGCGRNNHGSLGLGFRKKKIRKLTKIQNIPKGEIIDIQCGDSYSIMLIENENENENQNENLKRKLYSCGNYIYNGLDKNQNTYEFTEIKSSLFENDDNIIDISCGYYHTLILTSKGKLFGFGLNNLYQLGTGYTNTQTIPIQIKLPKLRFNENISNYHISCGYDRSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNENENEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLYVTEDKSNKVTDYSELSNKSFQLFEYWIYSNQVKDGIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR56</accession>
    <name>A0A9Q0LR56_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR56"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="329" mass="40250" checksum="353F858889A3D9EB" modified="2023-09-13" version="1">MDNNNNNNNNQIQNANQNENENEMKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVEKEPNTFEIKVHKSILSSRSPFFNEFLRDRDQINKIFLKQFNKREMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLKSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRIKSLKLRKYKHKMNAKKRLFHSFFSLFDKDSISKQDFDKLKQFEIFLPNYFLVDIQNKVIQDNQKEIENKEKEIEEKLKKEIEEKWKQIEEKNKEIEEKLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRE6</accession>
    <name>A0A9Q0LRE6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related protein rab-30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRE6"/>
    <dbReference type="OMA" id="FARGCES"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001204">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="198" mass="22572" checksum="3E59ED08BA151D7C" modified="2023-09-13" version="1">MSFDFLFKVVLVGAAGVGKTSLINRYVDNVFVHDSTTTIGLDFKTKDIQMDDKKTRLQIWDTAGQEKYQISFSSSIYKNADVVIIVFDLTYEDSLSKVDDFIKGIENNSKKDPLFAIVGNKSDLENQIEDVEQKIEDLLKEREFKFVKTSAKEGTNVNELFFDIAKELKENQPQNQQSKTIVLKDSDNQNSKSKKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRQ0</accession>
    <name>A0A9Q0LRQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRQ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="292" mass="34115" checksum="1579C3E23B71D9F5" modified="2023-09-13" version="1">MEKEKQTKSSDKSSDKSSDIDNKSDNENDNKSDNENDNKSDNENDNENDNQSDNENDNENDNKIDNEIDNEIDNEIDNKINNEIDNESDNDKSSDIDNEIDNNKSSDKSSDNDNDKSSDIDNNEIDNQIDNNNEIDNNEIDNQIDNNNEIDNNNEIDNEIDNEIDNEIDNEIDNKSIKNSNQNSKNSKNSIKNSLENENKNLKQKIQKLQEEKSKLLIDNQKSSQIKKTLEKTFKENKNLKQQIQEKNEEIEKQQENFDSFVEQNYNMSQEIEHLKEKLLKKKNFKNISRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS22</accession>
    <name>A0A9Q0LS22_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator complex subunit Med12 LCEWAV-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_00193</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021990">
        <property type="entry name" value="Mediator_Med12_LCEWAV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14754">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14754:SF35">
        <property type="entry name" value="TYPE VII SECRETION SYSTEM ACCESSORY FACTOR ESAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12145">
        <property type="entry name" value="Med12-LCEWAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12 LCEWAV-domain" evidence="9">
        <location>
            <begin position="302"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5076875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1427" mass="166593" checksum="9889543F3EE69A1E" modified="2023-09-13" version="1">MAIYCFQNGMLDRFLFLKEIIQLFRYSSSDENNSALMLIFLNTLDFICENFILLDGFINVCLKKLSLIEQHNLHLFQNKLVKEVSNFSKMENQEITGKRTKNFGKNNLLNQQKQSNKINFAARNIITKGIPNAQKNNSNDQAEKNMDIEQEGFENSANESANENEQDTQSHFYITSQRLKFFEQIFSVLQYSIYHAFDALSVVGVENLMKIKTFSEILFTIFPKQIFQLDSSMLSILIQRADILYQNSHLNFFDECSLVESLDALIEKGEAKYYQLFQSKGFNNFQGCPQEFGILSNEEQDKSVNSINLVQKENSDDFRFVSIICEWVVTRFRYIPYRNSIAIKVLTEYAQYRQQKDPFFDYSKQDSFFILQKPLLNFLDSYSPSVKEEKRIEELFGEFIRTDLFSHNLYSRRLISLGLFRIQKQQQDKLAQKRILFFKMIPTVGGFESKDFIHKMVLLEREHLKEAIQNEREAIRKGEELALRFLNSGEDFHTLLNHFNQFNSPFYIDQINTRIVEFVHNNIEKSQFEKDGIVVRNEILLLEISNDYQRLIDELLWLFENTIGFEKQLVELMQKYRGVFVLRGKVVELLMALIKKSEIEKEPNINTNITPNNLPMNILDLKSMIIECFRFICTEYHSFPEITQYLNHLLENNSIDSMIKRKINKILDSKTTNLAKSKHFKSFDFGKNIRKSQNQQTKANQNISQLVSQLPNINSQNMIKEFSNFFLTHSNTFTLNDLFIFYSSFITKINSREVNLYIAIQIFRELNFLSSSRIHHDQILLYVFKNQVMVFEKFTGELVAQFTDFLLRIISLGMVNINQVIAGVFQECLETESKKLIESYSQVSKERVAFCLDFLVSLLSESTEKLENNQYTSITLITTRFQIMPGVLFSLLTSLWRILMKFEGIFKANLNEDENENLNQNQINLQNLINLLKSTLVKITNQDNFRHACIFNASELHSELNKLDESFLSKLKLFALVRKAIIPEKHEEDIKDIKDMKDEENLEKENLENENENENENGNENGNENENENENGNENENEKKSFVRNKLCSKINAVLNRTTIWTTSLCSLELQLLLEYQKDIIKNESNTTKGGDILQLQQDLYAEFANAILERILDRPSYTSLFIRFELGKNIRKELFDKIIKWLSDLENALKPPSFCAAQTIGDALSQILEVCLQEKDADYSYLFMSLLSQLEKLTELHSSGKLAAKNFLSSAHLRIRLLNWFCSFLSESRVLSGLQSQERTNLAISAFKLAHNLLHILSLVSQIHELECENLFNYFLDVFTSITSITSKTLLQDDKSSSRILKEKNGDLWNYFNSLQFGHIHRDRIRKVLPYVKQNMFTNSSFMKDTSSDLLFQIAYGIPNPDRKDNLITLPIKINKPTLHDPRQIDPWTILEAYPESYFTPLVLGGKRLRNPANNQKWDRNDDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSX0</accession>
    <name>A0A9Q0LSX0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSX0"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12317">
        <property type="entry name" value="RRM4_RBM19_RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000442">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000738">
        <property type="entry name" value="RNA-binding motif protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="317"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="511"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="619"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="724"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="821" mass="94579" checksum="2F0BCED7E8F85C07" modified="2023-09-13" version="1">MSSRLIVKNLPKYIDEKRLREHFSTQGEITDIKLKRTQKGATRRFAFIGYKTEEQAKQAYEYFRNTYFDTSKLEVSFAKPIGSNDIERPWSKYSKGSSLYYQAHPEIQKQKKLEVDLQRKKKYQEMQEKKQKMFNESVANDPKLVEFLQVMKPRSNTKKWTNDEILKLKPVIKKKRKVGNFVEEEEMSIVSGSLKKNKNQIYTRRHKRFIDDEDPEKGDNLIGKNEEKDANQKSIQNDSNIFIETNSNSNVPVDNDFNANQDDSVVSIAFDDGVSDFEYFSSKKKEKLSDEIELNKNGKNEKENEEQVEDSLVAKTGRLFVKNIPFTTTEEELSEFFGEYGTILETHIPLKKETKQPYGIAFVLFKEPIDAVSAFEELNGKFFQGRILQISAAKEEVEEEKDEDNDSGAKDGMRRESKFQRKKQKERKKNAENTINWNSIFLSSDTVAEAVSKNLNISKSQLLDPQSSNMAVRLSLAETSVISETKAYLEKEGVNLDSFNGLNALTKRSKTTILVKNLPFSTEKQEIEEIFSKFGSIKKIIIPPTKAVALVEFIHPTEAKKALRSLAYRKYRHVPLFLEWAPLASLKSNDEKKDENKSKIMKQNLDESLKLTDQDSVGSTLFVKNLSFETDEEKLREVFQNFRVKSVKISRKKDVKTGELTSMGFGFIDFENKNEALKAIKQKQSVVVDERELVLEFSKSRGKSGKLGKKKNRKLVDLKKLKGTKLLVRNIPFEATRKEIRELFGSFGEIKSVRIPKKFDGSHRGFGFVDFVTKQEAENARSALLNTHLYGRHLVVEEAKDDKSIDEIRNKVGKKFGKQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT82</accession>
    <name>A0A9Q0LT82_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-coa acetyltransferase cytosolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT82"/>
    <dbReference type="OMA" id="CPIETPA"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="270"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5078587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="393" mass="41930" checksum="D5C7A7BC7A8F9CC9" modified="2023-09-13" version="1">MQQVFIVAAKRTALGSFGGVLRYAPAIKLATHVVKSALKESQINGEQVEEVIMGNVLSAGLGQAPSRQVALKSDISPKSNCTTINKVCGSGLKAVIQGIQAIQLGVSNVVLAGGMESMSNCPYYLDKHRFGARVGNSKVIDGVIHDGLMDATNNVVTGQIAEYCATKFNITREEMDDYAVESYNRALQALKNKWFNEIVPIRVTQGIRKPSRIIDEDEQITKNGDPEKLRLLRSVFVKDGAITAGNSSALCDGAAALVLVSEKKLKDLKLTPIARVLAYAETALEPMLFVTSPIDSLKLACKRANLMVDQIECHEINESFALVPILFERSLGISHSIVNIFGGGVALGHPLGCSGARLVTTLLSVLKVKKTKIGAASIGNGGGGACTLIIERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTE4</accession>
    <name>A0A9Q0LTE4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAA35-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000051">
        <property type="protein sequence ID" value="KAJ5078663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTE4"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="1">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="124" mass="14604" checksum="E99FB04364B79ED9" modified="2023-09-13" version="1">MQAVFKNRFNLIHFVLNPSHSYQTFTEKTEFLRENDFPSFCESALNSLDECQATIQECFEKRRKESMVSLIDDELESIKKLAFANKIAVKLILQLREKQKIPFLSFRFDIHPWLPVVCVSTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTW9</accession>
    <name>A0A9Q0LTW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTW9"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="325" mass="38223" checksum="DEE5CFF085FDA495" modified="2023-09-13" version="1">MLSKEDISSIIGASLGMIGALLIIIIYYKFKEFKNFYRNLIFILSVYDFFQSISYLLPGHSNKIVCRIQCEMLGAFALTSQFWSASISILSYLKIYRGIDEQKLNKIQKWFHLIMWLIVIGFIIFSAVLPTPNNSKTYWCATVEEVFLITFYSFLWFFLITCLIFYILIVFRLRKTMKLILGQYHTTKIRQMNEVWIEFRMSFIPLIYILIFIPATIRRIRSFVHSSASEIESINILQGLLSSSQGFWDFWIFVVFDPKIRKKLKIFCCRYKSEDEFKMEISKLDQKDAGNISIHSFIKDGSKNKILQSLVEVEVDDESESDSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV42</accession>
    <name>A0A9Q0LV42_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000040">
        <property type="protein sequence ID" value="KAJ5079084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV42"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10743" checksum="9965B1CF83BFCB90" modified="2023-09-13" version="1">MLIYLLFIINKENISINQELEKEVKQLTDSLINERNHKKNNNSISQYLLKITKKNYHTFQNLFFIEDDNFYEFLENNNNNNNEKKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV60</accession>
    <name>A0A9Q0LV60_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BTB/POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV60"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="287"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="55839" checksum="AA3C6ED2D934C2AB" modified="2023-09-13" version="1">MSLRFENKNKLIQDYSNLFQNHQFADFQVEIQMQNNKNSIFDCHKCILSSRSDYFKALFNSQMKESKEGKVLFSNVSPLIMNQILKYIYIGEIEISHENAIELLIESKKLLLDQQIIQTVTSFIKTNLTAENVVDIFHLATQFDLDEITKFSFDFILQNFLQIQNQNQQFFRLTEEDLISILSRNNFQFSSESDIFSSILLWIDFHSQTQNINPKNIFKCIRFCDMNHSELQKIQESNVIKNSFLHEIIQNILSKSAMDHTFQEKLKQKSVKSFQTRIQTPQNSTILLENQDYTKTLFDWIHDSQFFNTMQLGYLAKRDGFSPSKFHELCDNKGKTLVLFHTQENNIFGGFTSKGWVSDPNFWATKSLGSGWVKDPHSFIFSLQNSKSNSPQKFNIKPERNSYSVFYSPFHGPTFGDRDFAILSKTFQKNDPFDAFLSNFGYAYQVPFDLKDPKKFFSDPEKFTIDQIEVYFENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV77</accession>
    <name>A0A9Q0LV77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000005">
        <property type="protein sequence ID" value="KAJ5080631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="FNHPIVL"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="40"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="44"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
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        <location>
            <begin position="256"/>
            <end position="289"/>
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            <begin position="494"/>
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    <feature type="domain" description="BTB" evidence="4">
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            <begin position="706"/>
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            <begin position="861"/>
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        <location>
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        </location>
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            <begin position="1653"/>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1891"/>
            <end position="1924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1931" mass="224112" checksum="1B9A3C082439AFAD" modified="2023-09-13" version="1">MSFNHPIVLNYKLKQVYESILKKDLEFFDSIPDLQTTEQFENENEPFLNYSFKNESTNEIIKKLIEKQTNLNWIDKNRNNSLHSALINKYPKEIIELLISKGSDINSKTKWNEIPLHIALRNEYPKEIIELLIEKGSDINSKTKWNEIPLHSALINKYPKEIIELLISKGSDINSKNNWNEIPLHIALKNKYPKEIIELLISKEIIELLIEKGSDINSKNNKNEISLHFALENKYPKEIIELLIDKGSDINLKNNIFETPLHFALRYKNSKEIIELLISKGSDINSKNNRNEIPLHIALRFKNPKEIIELLISESSDINSKNNQNEIPLHIALKNNNPKEIIELLIEKGSDINSKNNENEIPLHFALRNKYTKEIIELLIDKGSDINSKNYQNEISLHFALRNKNTKEIIELLISKDSDINLKNNENETPLHFALKYKNSKEIIELLISKGSNINSKNNRNEIPLHFALRYKNTKEIIELLISKGSNINSKNNLNEISLHIALKYQNTKEIIELLIEKGSDINSKNDWNEIPLHIALKNQYTNEIKIMLLRDLNIFELNQNEIYQEMIDLFPKIYSFNDDLNNFLKSNDFTDIEIKSNDGFKFQVNKQILLIRFDNNKTILTRFINICRRKSKEIIQFALNFLYTGFIDFDKFIEKFNNQFNEKEKEKVYNLFKEIGFDSNWIKEKEGIKGILKDFHKFYQQEETKDFTIIFDNEKEIKVHKLILIIRSYLFKGMFLNVNDSSNQVHDYSGKSFETIQQLIYFLYHDKIDETKLSKENIEEYNKMSFNHPIVLNYKLKQVYESILKNDLEFFDSIPDLQTTEQFEKENEPFLNYSFKNKSTNEIIKKLIEKQTNLNWIDKNRNNSLHSALINKYPNEIIELLISKGSNINSKNKWNEIPLHIALRYQYAKEIIELLISKGSDINSKNNENEISLHIALKYQNSKEIIELLISKESDLNSKNKWNEIPLHIALKNKYPNEIIELLISKEIIELLISKGSDINSKTQFNHIPLHIALKYQNPKEIIELLISKGSDINSKNNENEIPLHIALRNKYSKEIIELLISKGSDINPKNIENEISLHIALKYQYPKEIIELLISKGSDLNSKNNQNEIPLDIALKNKYPKEIIELLISKGSDINPKNIENEISLHIALKYQYPKEIIELLIFKGSDINSKNNQNVLSLHVALENKYPQEIIELLISKGSDINSKNNENEIPLHIALRYKNPNEIIELLIEKGSDINSKNNENEIPLHIALRYKYPNEIIELLISKGSDINSKNDENETPLHIALRYQYAKEIIELLISKGSDINSKNKWYKETPLHIALKYQYAKEIIELLISKGSDINSKNDENDTPLHIALKYQYSKEIIELLISKCSDINSKNNQNVLSLHIALRNKYPKEIIELLISKGSNINSKNIENEIPLHFALKNKYPKEIIELLTSKGSDINSKNDENETPLHIALRNKYPKEIIELLISKDSDINSKNNENEIPLHIALRNEYPNEIIELLISKGSDINSKNNENEIPLHIALKYKYPKEIIELLISKDSDINSKNNENEIPLHIALRNEYPKEIIELLISKCSDINSKNIENVLSLNIALKNKYPNEIIELLIEKGSDINSKNNENEIPLNFALKNKYPKEIIELLIEKGSDINSKNNQNEIPLHIALRNKYPKEIIESLISKGSDINSKNNQNEIPLHIALRNKYPKEIIELLISKGSDINSKNNENEIPLHIALKYQNSKEIIELLISKGSDINSKNDENEIPLHIALKNKNPNEIIELLISKGSNINSKNNENEIPLHIALRNKYPKEIIELLISKGSVINSKNDQNQIPLHIALRNEYPKEIIELLISKGSDINSKNDENEIPLHIALRNKYPKEIIELLISKGSDINSKNNENEIPLHIALENKYPKEIIELLISKGSDINSKNNQNKLLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVB1</accession>
    <name>A0A9Q0LVB1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell cycle checkpoint protein rad1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVB1"/>
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    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003011">
        <property type="entry name" value="Cell_cycle_checkpoint_Rad1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01246">
        <property type="entry name" value="RAD1REPAIR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="291" mass="32953" checksum="FB9E4230906A86E7" modified="2023-09-13" version="1">MQVLNCQLTNIKLLINNLSAINWTKDQFAKCSISEGGIMFSVEGSSKSFEAHAFIDSKFFTEYNFRGRQIELRINLSILLDCINIFGKSSYGISTGTKSEITYPDNQGRFSIKLEENDVVTQCSIAIIKIDEDEFYSQLSFDTSNNSVYLAMPSEVLKEIFNELDWSCSHVKITFSNRPGFISFQTEGTDGTCHIRCSKDPKIFSFFQISQTQSNKYLLNSLKACAKALNYSSKVSIRTNENGMLLFQHVLLSDSRQESFVEFLLCPSVDEDSDDESENNLQNLSTNGRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVH8</accession>
    <name>A0A9Q0LVH8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NREFEPI"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="1692"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="1835"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2320"/>
            <end position="2359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="923"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1619"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1661"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2216"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1340"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1578"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1628"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1670"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2216"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2238"/>
            <end position="2247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2522" mass="297002" checksum="E5CEFEE61AE16F0E" modified="2023-09-13" version="1">MIPEIFQNKFSNNYIINNSSTVATLLNLVNENQTKDFSFTLIHKLFSFVDKNNFKKFEVLSCAILTKILEIQQKIEVQVEKNEQVKENINSIREILQLLTDIISSYGLNLQKLFVEMEIYNFLKQVFGDPLLLSSLIKNILLLLLAIFKNCPVNIATFKKQFGFKKLRKYIMQINQDLIDSEVCEIILDIMVNNGKFDINKNFLIENEDSALFLLQLFSKSNRDIFCQILDIFFQICEQSILNRSACSSSGFISFLIKFITKISDSPKSMEIQEKIIRLIEIISSLRITTNELKLIFSHLKSLPGNFRPPRSSLILSIINKITQKTEQFPRSFFNFSGESSFLRLSSVPQSIFKRGYSFVTWFRLGDLFRTKHPQMDEIYKPRIFSFMSKEKEGFELFFNNIIYPTNDGSNEDEKSEVQFKLSFVIHLPSKNVIKAQKEIRLQIRKWYFIALTHKNKASSFGKFVIYINGKVAYSSHNIKYPSFSGLRYNHIGSDPFGKNCFCGQMSSIYLFNEELSKPQIEGIYSLSPNYFLSFSEAEWIINSSKIVSKEDFLDGSLQSKLFMSLRSQAVNKDQFIDKNERNNVKAQFINVSQGTTSIIHDVIYRSNGISVLFPLIIQSDQPLGSQQNIEIFKTQENYKNLIDYSIDPEISNQIFNIIKNVLIQSPANQQGMIRSHGFMILSHLYQHIHASHITENLIISIQEIITQINNPILIKDMIHNFLLDYDLWIYCDYEIQLKLIETLKFIISFKTKVDTNQKNSIIFLRIRDLLDIIFLYLWNNSEKEQNVHAKLETKIHKNTGKILGKKPNEEQTGKLRQSFLQLIELSLNMNYNKGDILVLLSKCQIIQNNKIVFALLQQILRIISKNISILIDDLVEINFLDPFIFLLNNSSEKVRILCFEIIYHLHKYLLLIKKKDEKEPKQLISTPKQKQKQKQKQNKNNKIEQKNQSQEIYQKIDLHKSRLNSPDGFEMFHNVVIRFQPTQKIVDQLFNLLLIKLPYSQNMENQKMIKIQTPWILRTLFYLIRKNPNQVGLNIANRVFSLFNGNEANVKIFASQNYWQEWILQGFYFSEFSLDNSNDNPKDNSNDNSNDNFEQKINNTLLSIIKFVFKFIFINQEMVALDILKILNTLGIMEKDEQEFAFEQKNVFIHIFYQELLVGIDESIEYEMSKINLKESKKEYSLIFKSKFLDKIKKIKGAFESNLGDLVILIGYFILFDNKKEAMTLNFSQKKPKQSFVDPTTQLNQKLVQNLVLFLDKFGFIDSGLFFRNEEQGKQVFRFVLLFLFFEIEVSEFQNCSKYLDMLQRLFYIHGTRSKIEKQILEERKELIFITTSYLFKVLRFLDENENENQNENENQLENQNQNANSKINKQRLIAVHLQTLIRNFYEMFASFLKLQNGGNLLPKNIDLTKFSTYNSTELIDIFRSKKWEFAIKNQLSSIGIQFSEDIQERRNRYEEEIQNQYKKFESKLTEKLMAKKNNISVIQNNLQETFFNFVRREKEIAEQREIKYQQRKKFIVSYWRKIFRNLTNERGPWGNGLKHKESNEIFWKLDKTEDSLRRRMKMKRNYKYSSYYHASVRRDERLISETNKRISEYEQQKQNDLEKLTTGIDMIPDENVLDTDQDENENNNNNNNNNSNNNDNNQGYLSDKSNTSQIMISVEQSQTESEFESDHFQKEDPEDKQEEQEERQFIQQLEFIYTTKCRFVSPMKSCPGRFVLTKQYLSFIVDPKIEEKTQIDNIKRLGNFQKKEKIGKQTGNKFQSAKHPKENKNKSWPLNQLKTIYKRRYLHQQTALEFFLINKKSFFINFSKGVRDEVYERIINIKPSNLVIEFETGDPQKWIEQSQYTQKWQKWEMSNFEYLMKLNTIANRSYNDVSQYPVFPWILSDYTSLEIDLHDPKIYRDLSKPIGAMNEERLEIFKNRFDFQLKQGDTPPFHYGSHYSSSGGLLYYLIRLEPFTGLHVYLQGGKFDQADRVFNSIAEAWNICQTSTSDVKELIPEFYYLPEFLSNKNKYNLGKRQRSQIQIGDCLLPPWAKTPEEFIRIQKEALESEFVSQNIDKWIDLIFGYKQRGKKAIKAFNMFYYLTYENSINFENINSSNEKKSIELQIEHFGQTPSQIFRQKHPQRLPIKQVIHNILDLTLYWRLKSDQRYRKFSSKVAKSPIIFVYFSKADELFSSWEYPIILTIDENRNVGMHSCSLSPYKTFTKEMEFNIEEENENGNENENQNENENENENSKSKSKSKKIAYSKKSDNPKYLFPFKPDAQYDNRSQIGYSYSPKMNNFANCFYFVSERPLLFSCGYWDDSFKVTDIEKMKLLQSITHHSDIVSCLSYDSGYLATGSYDTTIMIWRFNEEQEKIDTNPVHVFMDMIAVTCLDISVDLDVVISGSEDGTCIIHTLLEGKYVRTIVNENFSPLTLLKITKDGFIVTFSESDHVLSVYSLNATLIMKRKLLENIKCLDVSNDSKILVVGTEQKNIHLYNLHDFSLIQTFEVDDSVISLRFYEVWRFILVGTSQGKIILLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWD2</accession>
    <name>A0A9Q0LWD2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_03783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWD2"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022340">
        <property type="entry name" value="GPCR_GCR1_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02000">
        <property type="entry name" value="GCR1PLANT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="6"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5080298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="301" mass="35174" checksum="0AEFB76209AAD385" modified="2023-09-13" version="1">MAHGREVLPAIIGGTLGLFGSLVIMIVHIAYPSIRNFFRKLIFILSIYDLLLSIGFLINGPSNHILCRIQTVWGSVLMTATPSWTATISFITYLKIVKSVSDSKVDYIQRWLHFFTIFISLVICIIWIIFSRPEVKEAYWCFEKEANLLFGIYCIWWFFLLVILIFYILCLIKIRQAYKAIMKIASQMEKLRKKEKLKIQLRMTLIPIVYILTSIPSSIKRARDYFQPNASDLKILDVLQALFLPSQGIFDCFIFVFFVRIVRKKIIDSLFKCCRKNQDRSLVIPLVRESYFSDEFDTEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWG3</accession>
    <name>A0A9Q0LWG3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein rab-21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000036">
        <property type="protein sequence ID" value="KAJ5079140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWG3"/>
    <dbReference type="OMA" id="CYCENKF"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="212" mass="23919" checksum="77CD2457E9992500" modified="2023-09-13" version="1">MESFKHYKIVLLGEGRVGKTSILIKYIDDTFDPDMKSTKRAAYLDKSLDLPEGRVKLSIWDTAGQEVYHALSHIYYRDANGAILVYDITDLKSFERVQHWVKELLSILQKKPVIVIAGNKYDYANKQAVSSEQALQYAESVGANHYYTSAKTGKGITEIFTDLATQMFKNENPTNSRSAFVPVKKTSIIIDPDKSELSPTDQKKPKKKDGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWG4</accession>
    <name>A0A9Q0LWG4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000016">
        <property type="protein sequence ID" value="KAJ5080020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWG4"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="303"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5080020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="506" mass="59686" checksum="0D604AFCFE5053C4" modified="2023-09-13" version="1">MSKEFSNIQKLSQDLQKLYFSKEEEIYSDFEIYCKTNEKTHKFKCHKAILSSRSQYFKSLMRSRMKEYQESKITFEDISKENLNTIIQYFYTGKCLITSENAIEILLFSLKYLIEELIDFTVNFVKKNCQVENVVDILKIAQSLNVTQLLDFCYQFICSNFSQIVATPMLFKLNKDNLLRILSRDYVNISEFEIFQALISWGNHAYPYKNQNENFVADKNLEIRNKLSHLFCKLRFIDFTDEELDKAFKTDLIDKEIEKDFLQFKSLYSLKKESPNKLENFQEELEKKGFLIHKSRFFFKSSILSQSNQFHTLKQWMEDDIFFKSMKLGFLASKDGFSSETFHSKCDGKGKTLVLIETTNGYILGGYSSTGWNIQKSNPRKDPKSFLFSFKNSFDTQPLKFDVIDPDSAIYSFIDDGPNWGAPDLKLRHNMQKLWINLGIRFSCPSFVDQSKTLEFLVGNDNEKVKEIEIFFNDSDPVLNENENENENENENENEHEHENEKDDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY69</accession>
    <name>A0A9Q0LY69_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY69"/>
    <dbReference type="OrthoDB" id="47475at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="606"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="905" mass="107245" checksum="2412CBC0F5970C45" modified="2023-09-13" version="1">MKLFFIRFQGNFCVFDAEKILNFKTLIKDVKDNFNIRQKIQAFTYLFQDKTVRISNNSQLVIFLNCVKEQVLLITSEEIPILNVQISISKSGKKVPMNTQKMIDQDPFLSYDLDTQKVFCSSCDKELKNLNSWKLKRHLNCEHHRFKIPFYLKSQTKSKEWVFTNHEKNILRILDHLETFTTIDFYSRKDIPVFRTSLTKKRLFNQIQDKGNDLKYGTFCSLLQKYFSIHSATAFFFQCPKCSNPIMKKRQNHQRKVLEMRNLYKSEIQLLDQIILFLDFAVNFQEYRDNWETQEFYHKKSWVIFNITIQFEKQLFYFDYISEDQTKDSQFVLQSFQDFRYKFHEWQHKRNLLNISKLRIFSDNGGHIKNNFVLGMIFDAFSSQFLDIKVIFFLKNHAKHMSDRHFGNISRNKANFGDITTINSLFDYLSQLSNTTPIILNVNRALKFLYKNPIAKIKKSHIFIFLKGNLKTARMPNTNFRKRRIPIIEQIFQEKEFGIKQNSALIQENYSIPFFNTQMTNSKNEKVIPNETQKFHSQREKKMKEMNHMNGNLRSSSRKHQQIKRKIEFEEKEEIKNLRISKFQDNLPKQKNFTSSISICKTGNLRKIPNSHNSCYIASIIQVLLRTSVIELLGLGDISETLSDILQSSEESINITPLRKVIREHVTQFSNTNEQDIHEFFVSLMDLISNENISDFNVPYDLLYQEFDIHNRAIINDFRIRIVQKVTCKKCKRFTYSFPQETSLVISFPILNGEISISSMLDNYFAEKDLDFSQHYHCENCDQKVERSIKLSLLTIPKYLVIFFKRTYYDSLTQSTTRIGTKIQCEEKINVKSFMFQSCPNQETEMKLLGSIHHIGNANEGHYWTEILETETSSNFFGISDAHIFPVNPFRTEDTFTMMIFTRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY91</accession>
    <name>A0A9Q0LY91_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000032">
        <property type="protein sequence ID" value="KAJ5079490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY91"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="17835" checksum="0322164B147BD7EA" modified="2023-09-13" version="1">MIYSNNSNINPKLYSEIKEIINSNEKIEETMKRIYLNENENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIEITQEIIDELETGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYZ2</accession>
    <name>A0A9Q0LYZ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000018">
        <property type="protein sequence ID" value="KAJ5080003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYZ2"/>
    <dbReference type="OrthoDB" id="61627at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="523"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="737" mass="87992" checksum="BEBA5084B2C57482" modified="2023-09-13" version="1">MNKNLIKKGWNQNPKERCSLNEFIQCLEKIKIEKNENSFQFQQFPPFQNQFQIQNQNQNQNQFQNQNQFQNQNPLKNQNLIQNQNLNQNENQFQIENQYPQKQFQIQNENQNQNQFQNENGFENENQIENKNENQNQIENENGFENENQNENENENENEIENKNENQNENENENENENEIENGSENEIENEIENEIQQFQQYPQNQNQFTQNPYYEELKQISEDKQNEKENNQMISSINQTMSYFEKLRDSIQQNDKDPRKEVIQFDLSFIFEYMNNFPSDRFIQESCCSALRKYTEIEKKIPLNFQNLNPFDLIIKAMINFPFTAYLQFQCFLIFINIGKEKKKEKEKEKEKEKEKEINKEIAFEAILSSMFNFHEDKQIMDKGTEALEALGMEKKEMMKKFKAKKKIEDKKDEKLLELLKKQYQNSKHNTPIHYLCRNKTITLDIIKYFIVKGSDLNLKGITPLTYLCLNKSITRDIIQFMITKDKYLQKITPLDYLFSQKPFPIDTIEFLITKGVNLISQDNTPIHYLFRNKTITLDMIKYIIKKGYDLNLEARTPLNNLCLNKSITKDIIQFMISSRFNFNIQNDSLVHYLCRNESITFEIIQLLISNGADFNLNGWTPLHDLCRNESITEEIIELLFNMRCDFNIQYQSPLHLLCQNTSITIEMIRILIHNDANFNLQEWTPLHYLCQNPSITDEMLLLLKETNANFDLKAIYAWSKKTPRDLLPQNYQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZP5</accession>
    <name>A0A9Q0LZP5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 33a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZP5"/>
    <dbReference type="OMA" id="WYDEDEH"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="653" mass="76682" checksum="E018A6E4C3FCA92C" modified="2023-09-13" version="1">MTAPVNLENPKILKDIGKIREEMYDQFVRIISRDEGKKTMIFDEELLIPLSLIVKPEVLRANGVEKIASLKTPPQKNDMKIFIFLVRPKMDLMLQIERYVKFYDMDEDQNRKQFFVYFVPRKTEICENILAQRGVKGGLVIREFKMDIVPLDEDLLSMEFEESFKEIIEGDITSLYDIATAIHKIQRFFGLIPNVTSIGKNAKAVSEILERLRYESIIDESLEPKIQNLVIIDRTADMLTPMATQLTYEGLVDELFGINHSFIDLEPEYLGKKGKEKEKYPLNSNDLVFEEIRDLNMGEVMSFLQNKAKYISESYDSRHQAKTIHEMRDFIRKLPTLQQEHHSLELHFKIAEEIINRTLSKQTFVSRMETEINLLTESTSALEMIQEMIWREEPIVNVLRLLCMESIVNNGLKPKDFDLVRRDILQAYGYKYIFTLDKMEEQHMLNKEDPLIKKNKKKMFRFTFPFLRKELNLANDNFLETGDITSVFSGYAPLSIRLIQRHLERPPQFYNQNPFDFLKDAPFYFLRQIPEKKERFYYNLKDTKTNPERRESINTNINTNSISNANLSTNIRDNEDKNQDFDENLDQELNTEKEEQQKSICLVFFVGGVTFAEISSLRILSQMENSRFEYVVATTRLVNGNTMLNDFIESLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4J6</accession>
    <name>A0A9Q0R4J6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_03541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="131"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="484"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="8">
        <location>
            <begin position="1749"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="824"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1692"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1694"/>
            <end position="1713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5066208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2100" mass="245237" checksum="717C8AC528EEBAED" modified="2023-09-13" version="1">MQNPIFAKPLFNFETKIDTFLQLNTNEKVLILREDHPFCFCYSIEKEKEGLIPLNYLKIISKSKIQNKNEKKTMNEKLKTSIKTSSELRKELENKNEKKGSSLFEYSDTYHGQKIVPVYKFSLPDQLPAFPIELSSNFQIQGTVGDWKQRWVVLENNEIRYYKNKTSLNQPLYNLPIKEIFDVVIKTPDAFIDGITTKTPQKRKSLAKLKTDSDNSFKIILKNSSLTFKSKDFNSLSEWISNIHFLRVLNRISSSTANKTDYALIQNLLLIVQLTKGKIKADNQNNNTKEQEKENALNFWESFLLLQLFLSQKEDISEEFPQITFKRKNTIAEINESVISVTNELLNSINPKIPNTQNQNQEQNQTQLPVENEKERLEQQKLYAQIRNLCNAEYIGLTLSNYHAKTENEISYRQFELIKITKAYDNLDLFWHGHIFSDSQPLCGDFSPKNIVLIRPNQDNILNFAKIISQNSENQEQDIARNIQFQKIGIVFHQDGKKLQKWKKNLFVISSLHLQSFPLHNCNPNTQFHINKITSINRVDTSKNASKFTLEIITQNQVISIYTKSQDAFNEWLNSINLTLTLSNINKKIMDHPLTISRLIQDYRKLLCWISSKLSSANAFLMGLNKISQVLSFQFTEKFGQDESLQNDFLSNQESFQTFFSTSLQMTAHLNQKSLLLQIQKRLLPKIARLLFLDLSDDSFVGYFLQSTKASLYSSSKQQNQQQSNESQETVDIEKGALLAVSSQFKIEKIDDIPNQVDFQWKENSVVRSEKEHFIIIHPSKKEEIFLEQKTAPPPTLPHLKSAESLREKNTKINSLRHFKRTVSIDTQRSAKKSNSGLLPNSEDQNQPNSNSMDSKMKAKFLYLFNLNNLVHPKDISVALQCLDIWKKSENKDHMYFPTEISTVGFAMINKKWTRSWIHLVSYILLLYKSNYSERPFKVYDLRELASIKRGSDLQHSNLITLKLSENDIKLAIDSTPKSEEMADYFGALFNFVFFIKLSENIQKNTQISSFRLHNLLKWIEKQHAIYKTTFESSWNLIQFYKENEDTSGIASLNKFITNNREKIQHLKIWRKRIFKRLFENEFPDAGPSPTGIIYGYVFMNEETTQNDVGIWIEVQNNENENLNENGIENGNEIQNQNQNQNENQIQNENEIENEIQNQIQNQNQNQIQNQNQIQNQNQNQNQIQNQNNNNININITIVDDSKFIQENPNVIKATQIKPKTESQQTLKTFEIKDCLFISNANRENFEQFQNSEILKRLIHNSKKKISRFEIATTKSQFKQEKSAPETPQMFKNPNEPPLYKKGMVYCSTSKTRFSRWSKNIITLVGFKFYRIDMKQYKQVETVILSDIVGIRICSDHEENYPNLPPIYQQFILELTMGKHFWRISCSQKEDFERWILCFQVVNTLHFFQCIEFEPETKENLFIKDTENRDEKKEGLNQDVPKDSREKTTGQIVIEPKDYRLYFQEMKARLDDNRQNLLSSQSFQNKNKTVYKHQQIFQFLTKIENQKALEELRDWIEKEINICIAQQRSLSSMILLYNQSNVDEINSIENEINFNKSLSDLLRIWLRKILSVLLSFHQKNLDKDSVMAYVLSPFVKNDVEFLQKEWVNIVDIKHTETPQQLDNEKPQNNVQNAEQIYYIVEKNGKNFNVEMNKIEIIEPAKMKKVKPIHIRFYGHMIDPTVYLASIKQSSDSFAESDEEDDEDNDDEEDDEDSSAITAITEQQRDDLTNILIDDDLVFFTQISLLPIIDYDSFGKNIVYIFLYKNNIHTLLNHVINIEIANTHHETAIFRTNNLTCKVVSNFAKIIGKEYLRAIITPLITEMHNHLKSDPQASFTFIWQKPMTEDSNLRVTNLIKHFACKFLDRIFNSVVEYPLSLRRLCIQLNTKTLEKFPDSRHLVLKGFVFLRFICPAIVAPQLFGIIDDEKQDEFMTPELIQGLLSISKIIQIIANQKLFLEGTEMVVFNEFVQTYFSKIQVFMDSLLTPYFIVNSKSSDSSLDISIGDKILVLLQNDIHVWGQKINSQNPPFQIPKNILDFDSKKDVSFEQESTPISRSNFDLATENVFHFISSKKISKKILKNLEEEQEQSNISEKIKEILQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4N5</accession>
    <name>A0A9Q0R4N5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GICICKN"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="44"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="37"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="436"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="563"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="599"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="669"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="705"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="741"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="776"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="812"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="850"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="888"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="926"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="964"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1208"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1246"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1286"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1324"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1362"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1400"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1497"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1537"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1575"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1612"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1919"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1790"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1790"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1826"/>
            <end position="1865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2021" mass="230953" checksum="16E52658560FC4D4" modified="2023-09-13" version="1">MNQKVLFQDLLSACQYNSFESVKFHISKGINVNISNNFNETPLHLICQNINPESFEIIKFLVSNGADINAKTYHNETPLHFVCQNRKLSENSDEIIKFLVSKGADINVKMQNNETILHLICQSPNPKSFEIIKFLIENGADINAKTYEDETSLHFACQSPNPNSFEIIKFLVSNGENVKIKTNNNETPLHFACQSSNPNSFEIIKFLVSKGLDVNAKTNQNETPLHLICQNPNPKSFEIIKFLIENGADINAKTNNNETPLHFACQSSNPNSIETIKFLIEKGLDSSYKTNRNCTALHFACQSPNPNSIEIIKLLVSKGLDINAKTNTNETPLHFACQSSNPNSIEIIKFLVSKGLDVNAKTNNNETPLHFACQSPNPNSNEIIKFLVSKGANINAKTNNNETPLHFACQNSNPNSIEIIKFLVSQGLDVNEKTNQNQTPLHFVCESENPNSNEIIKLLVENGADVNIISHNNNQTPLHFVCQSSNTKSNEMIKFLIENGADVNAKTYVKQTPLHIVCQYQNQLEFPFQNENENENENENPKLFESIKLLVSKGANVNDKTNYNETALHFICQSKNSNLYEIIKFLVANGANINDKTSRDMTPLHFACKNRNKNSAEIIKFLVENGADVNERTENNETPLHFICKNLNSVEIIKFLVSNGADANEKTNNNETALHLICRNLNENSMEIIKFLVEKGLDINAKTIKNESLLHLICENPNENSKEIIKFLISQGLDINEETNYNQTPLHIAFTHGYSLQMIDFLIENGADINKKTTEKAQTELHLICQNINENSFETIKFLVEKGLNVNEKTDENNTPLHLICQNIFGNENLFQIIKFLVEKGANVNEKTNRNQSPLQLICQNPYINEKLFEIIKILVENGADANIKTYQNETPLHLICQNETENLSLIETIKFLIEKGLNVNDKTNRNEAPLHLVCRNPILKQNLFEIVKFLVSNGANVNDKTNQNETALHLICQNQNPNHDSVEIIKFLVSKGANVNDKTTHNQTPLQLICQSSILNSYSFKIANFLIENGANVNHKTNQNLSLLHLILQNQNLNENSFKIIQLLVSKGIDINDKTDQNETPLHLICQNKNQNPNLFHSQNFEQYLNLNEYSLEIIKFLVSQGLDVNDKTIYNQTSLHLICSNPNPNPNSIEIIKFLVSQGLDVNDKTIYNQTSLHFICGNPNQNENLIEIIKFLVSKGIDVNDKTNQNQSPLHLICQNPNINPYSIEIIKFLVSKGANINDKTNQNETPLHLICANQNLNLNPNSVEIIKFLVSKGANVNDKPIYNQTPLHLICRNPNINENSVEIIKFLVSNGANVNDKTNQNETSLHLICQNQNPNHDSVEIIKFLVSKGANMNIKRIDNQTALHLICSNTNINENMFDIIQILVSNGAKVNDKTDQNESSLHLICKNKINSILFKIIKFLVSKGANVNSRTNPNETPLHLIWQNLSHRNNYLQYTSPNIDLNTNQIKNQDGNGIEIINFLISNGANINAKNSKQKTLLHLICQNQNLNQNSVEITKLLVSKGANANVNDKTNKNETPLHLICQNQIPNPNSFEIIKFLVSNGANVKIKTNNNEAPLHLICIKDPNPKSVEIIKFLILNGANVNSKSNQNETPLHLICQNQIQNENSIEIIKFLVSNGADINIKTIYNETPFDIASKTKNQEIIQILFMNDLILFDFRKYLKIQKQFNIANFNQIYSFNEDLNNLLKSNDKFTDFEIECKDSFKFKVHKLILLTRFDNDETILEKFRNFCKEKTKEEVEIALNFIYTGLFDFELLYQLIDQIQNKNKNKNRNRNRNRNRNRKRKEMKSESESESESESESKSKSKSKSKSKSKSKSKSKSKSKSKSKIKSKIKSKGHKKSRKNQNEIKIKQWKKKEKQNKQFFQEFGFDLKWIEIKKGRKGILKDFHQLYQKEESKNFKIIYSEKENENQNENEIKIHKLILMLRSRLFKTMFLSIQDPINQVQDYSGKSFSTLNQLIYFFYHDEFNYNMRMNFNFIEEFQDLKDFYQLNPNSNPIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5B6</accession>
    <name>A0A9Q0R5B6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_03225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5B6"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5066881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="489" mass="54808" checksum="74700CF0DE810EB4" modified="2023-09-13" version="1">MNQKAQVLAKNYCYFIDKAVTPAHAVDEMQKLLKLYEFQPLSEKKSWKGKLKKGGRYFVIRNGTSIIAFVIGDDYDPSCNGFNILAGHTDSPCLRVKPISKIKKNGMLQVGVSTYGGGLWYSWLDRDLTLAGRVIVKERTLFRETLVNIQKPILNIPSLAVHLSRESGENLKLNKENHLVPILSSFISKEFEPKIPNSDHHPLILMGISEALKVDVGNIMDFDLSVVDTQKSVIGGALEDFVFAPRQDNLASCFISVKSLIDSLDDKSLKNESRIRMVACFDNEEIGSMTDQGANSTYLANIMKRITKSFENHDFDVALRDSFLISSDNAHGVHPNYSNAHESNHQCQINGGPVLKTHVGGKYTTNLISRFLIRQLAERNQIPLQDFVVRNDSPCGTTIGPITVSKVGLRALDIGIPQFAMHSIRETTGVLDLLYLYRLFLAFLQDFNSISSELDTLEEIPFLSQPVLNQNDDNDDNDIEDIQIEKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R651</accession>
    <name>A0A9Q0R651_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R651"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="407" mass="46208" checksum="917F9ED977D5900F" modified="2023-09-13" version="1">MGINHSKQKENQKQINLFNEESLEFIEKGNGMENQMEAIVIDNGSGMIKAAFSGSNAPRAYFPSIIGRPKFSKFMIGAGIREYYIGDEAQSKSGILNLEYPIEHGIIANWDDMEKIWHHIFYNELRVAPEEHPILISEAPLNPKSNREKITQIMFETFNIPAFYISVSPVLSLYSSGRTTGVVVDIGDGVTSVAPIYEGYALPHAIQRLDVGGRDLTKYLIHERILENLLIKGISQSAKMRIYTDIKEKLGYVALDFDEEMEKHQKLIETKYELPDGQIIPIGNERFRCTELLFQPSLFGLEYSGVHEMIYNSIMKCDEDIRKDLYGNIVLSGGSTFFPGIAERIEKEVTQLAPIHFKTKIISPPERKYAVWIGGSILASLPTFQKIWITKEEYKESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6P1</accession>
    <name>A0A9Q0R6P1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6P1"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1192" mass="134106" checksum="08E63B1EDA09173F" modified="2023-09-13" version="1">MTELLSYLKEGKLKEIQNYFKKNPKEINEAITLEENKQKEEDEIELESDNENNNNNNNNDNNDNQNDNQIPNVLESGLNPIQICSQLGHVHLLKPLVDLGADINSKSEYEQTALHLAARNGNTKCVTQLLDLNAEISPVNAFGETPLHISIANSHKAISQELILRKAVLDRMDSNGKTPLTLAASLGQVDVVSRILDSLEDPGSVINEADGNGWNSLHYAVFYKHMNCVEELVKRGADVGEETGNFCQAMHLAAQQGWKEGLGFLIKNKADVNAISVNSLLSLGKVGEDENFENQEVKKLAKKSLKNKQTLGREEEYDPEFISTPLHFACRYGQHEAAEFLISQGANVDQRNKFGAKSMHIAAKYGHVECISVLVRNNANVDDQDFQNYTAIFYAVREGHRNVVEKLISLGTDAKHVDDEQWNLIHLAAFFGHAQIITMLIDLGVDSQAQTARTQTPLHIAANEKNEECVQVLVEALKKQDDQEDPKKDQKNQKHGIDTTTKAGWTALHFAAKAGSLSVVKFLAENGADIHQTTSYQSNAAHLAAQEGHEEVLGYLIDKGCDPNVKNQGQAVALHLAVVGNMLSCVRMLLERGADVNAQDKNGDTPSSSCSYVRHGRLRFIASRSWSKHKAPKHERIVSPPTNENEKEKKKVVIVEEVESTQTGDTLVDEVWGKIHSFDETIQFVKKCAAIKKDSIELSQLLLSLADILDNKANQTADRAEDYHVVYLKVQELMNYSSQTQSVDNTIYPNENDADTNDENMETQKIEMNMDLDPKRSLLHVLLNFGFDMTLYHFISIFNQEWKGIDHNAKQPKVFWFDQNAENKGIIETVKKVCPNVSLLGNLPSDPQVVEDNYKSDLANQARSISTRVICNNTSAQTILPLLRRQWGSNIPVLIYCRRIEVAHELIRKNGFRNVWVTSLDRLCRLFAASTQKPPTPLSLTEFRARGKDKALEIVKILKKSKFLKKFSMEERLYTVLKMAYPVPSSGGLFACTYLFDILLELELNSTRLMSTYPIGKIGNISKIIKALGIAVLNYAIDFDFEMFRFLFQITAEREANRKILWIDVAQKENKMVVRSCKHVSVKVFFPPTKKIDIGVKKNVNVVDLDAAKVFVSKFLDENLGANVFNCRIITNYFNAKEILPYIRNVLKCDLPCLIFCSTKNIKEATTFAQSFRGTWASTHFRNTVKYAKFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6X2</accession>
    <name>A0A9Q0R6X2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(+) ADP-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_11601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6X2"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="410"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5069429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="570" mass="66220" checksum="F41F290AE8838C29" modified="2023-09-13" version="1">MEIFSKIENGEFEEIQKIIEQGGDVNQKDDVGKTPLHYAVLTPHIDIVDYLLFKGADPNIEDDDGNTPLHKVALKGNLEVVLALIGKGANQKPNFRGHLPQQIAAKLRHTECVDALSSPAKFQRKRPSKFASNEQKSTQNNESQENQLNTSTKPKLETKTKTKTKTKTKTKTKTKPKLQSKSKLQSKTNIKKKSRRNFLQKMSQDFQNKSEIPDQNNLQQSQEVNLQEDNKIEEDNKIEQDNKIEQDNKIEEDNKIEQDNKIEEENQENQENQENQENKIEQENQENKIEENVIKKKNPKKNPKKITKKKRNIQENKIEENNQNDENNENDENNQNDENNKIDENEQEIEQEIEEEIEQEIEQEIPKTKFKFDFKNFQQPKRFIKQPQESKLHFSPKNIEKLMEKPVNQWEISDVSNWIYSIGFPNYVSNFTQNHINGNFLLSLNLENLEKEIKIDSFGARKLIYEKISLLSSQISKSSLSFIDNPKGSVTIFIPESLSISNSLNQPVFQIILNLPSFEILKEKISSKLKIPKENIKRIISGKNPPINIIDDFDVSQLKNGDYLFLQIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R724</accession>
    <name>A0A9Q0R724_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ubiquitinyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_02234</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family. USP20/USP33 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R724"/>
    <dbReference type="OMA" id="NGVKYSR"/>
    <dbReference type="OrthoDB" id="73004at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF86">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="220"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="16">
        <location>
            <begin position="788"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5069657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="910" mass="108072" checksum="9D9CB57A6A2064D6" modified="2023-09-13" version="1">MICEHLKQIEKFTFLQKIKTNKNKNKNENETKNENEIQKKLKNKQIHCYLCQQTEPNLWICLHPNCTFIGCTESRVSHSISHYIKKKHPLCINLTTGVVFCRECQKEISTNFKYEDGNIQRRIEDLKEIKNIIQYYNFERKKDANLIENENLIENENLIENENLIENENLNENLIENENLIQNENENQNLIQNENENENQNFVENVQFVQENIVAFPGLCGLQNLGNTCFLNATTQALFACEPLHHYLASCKFDFADSGRFNIVCSLRSLMKGAWSGLHKYILPKRLHSAICKISPMFKGYSQHDAHEYLIALLSGMHELLKREISEEKNQNQNQNQNQNQNQIKKNKNEIKYRSIISDIFQGEYKSILQCNQCGEIRSSSEDFLCLSLPIPQKDKNSHNSNEEKQKTSPHQNKLKTNRSKIKREILLFSLSTIWRAFTFLIFKFPIKFIKAFFNFIINFKNNFLSDFLFSEDDFSYPNEMKSNPFSSQQKNSNEKEEEFSCNLDDCFKKFCKINKLEGSNKLYCSNCQKQTNSKKHIQISKFPEILLLHLKRFNYLDSKSRKISTKVEFPISGLDLSKFKVDYLKDLEENEEPILYDLYSVVQHIGSADSGHYVGFSRNLFNEQWFEFNDEKVSQISEQYLNTQQAYLLFYQKRPTHMEINRREYITQKLEKNIGFEFTSQIDNNFILQNNLFGISRIWYEKLLHMSNPGPILNSELLCPKHNQFRYICNRFKIPKEFKQQKIQEDKYPLFSRLIFVDQEFFEELENIFGKILRIQNINECGICKKEHLDLKKRRIFEIQTMNKINPNHFEKKDFYYIIPEKWISQWKNFVHSEDLIHLPPSKIDNSILLKSDKRTPKKNLNIIKDYYVINKESWDFLFGIYGGDPIIIRSQKTIDLKYEIIYQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R780</accession>
    <name>A0A9Q0R780_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beach domain-containing protein lvsc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="2621"/>
            <end position="2725"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="2742"/>
            <end position="3036"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3179"/>
            <end position="3209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1621"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2150"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2561"/>
            <end position="2582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1624"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2567"/>
            <end position="2578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3386" mass="398211" checksum="16612E05EC370EF4" modified="2023-09-13" version="1">MTQENNTETTDENFFLNFSGGEKLHEMWLTQLEKKGKSSDNYVEFCLLFQKVFASWDPPESKKTTTSKDYEFENKFEQKEVEIAIQNKEAHPLKFLLFTFNHLVYSKSLVQDIIKEEKEQIENENQNQIENENENQNPKISLESLISLSVVTTLTKSKFNRQSLFNYGLFDIIMDFLDLSIELLKLVLNLRNTQSSRAIYLLFESQFILFEIVEILRRFFRNRNILPNMEILQLIQDRRLSASLISCFHFNLQLKKSFLFTKKQYDLELRFIDILENLYKLSLFQKKEKTEIILLLTSFFAPPVSSLPNLGVSSESENENGKKNNQIQMIENEEYKNYKAIKQQKKLRLKKFFDSIRCNINQLEDLFFTNFFVFDPKISRKDNLMIIDNLQIDKFAVKHVECELRTNAFKFIILFIQQENIIEQIVNITHIFYLRDFILWASFAFQPDFAKRLRKFKFIKTTTTTTNENNENNEIQKKNIHNYQLIKPLKVLPISEIFGSQEKRRISKSLSDFKLYHHYFDSLFKNLRDFHKASNFSQKKPNDYIIKELDKFSDESRILTTFQERFILIYLDLFRNPSDLQSSNSILTINDQIQSYIKNIFPELQMYIILELQRIVDQSNLSFFRSNSGWEICFSDYFVRNCEDVITDSEETKTKVIEMNNNLQAYLLRFFFDIITTYQDDLDYIFLFKQVLSAQKVVSNIPFLIKILKMITKILKKEFQNTANKIIKNGGFEAIRNILKLLTGYDPVELHEKKRKTELNPISNHPLVSKAIYLCFKNFHFLLSSPDIDQIFKHPEIIRFLVSLIRYKNIQQLSFYHISKLLENVKKNGDSQKDFILGMTEEILVLSQNFNNTQVQNNLEYEFETIKRILEIFVKVLPKNRNILQNLFLDSNALIMLMTLLNYRTTNTNLTYTLLSMLLELLRNNDEMLSHFQEIVQVRSLVTLLYQAENENPSGKLYQILLNLMVNNGVFDINNNFIIRNADIVLVIFHLYTKNTNKLDYQEWKTNDNNNNNNNQNLKEPDQIISQISFLVVLETFKAISAKSIHNISCCCEKGLLFLLLGLIPNIKSLHLFQKIQEFIGQLGSHKILVSELKLYFSLLKHQLKNENKEFANSMIFALRNMINKVQEGPTNFFDMSGENSQIKLPSFDKSFMDKKFTFCTWLRIENFQGTPSLSSRKNYKPRIFSFLTDSYKGMELILDLDSQQQSFIFQLYPQHKEKLNVHFSVDIKPKKWYFVSFIQKYIRKSSQVIIALFINGKMQTSLSLKVPNPITETEFTKNCIGSNFPFINENENENENENENKSHEYFQNPFYGQMGTIYIFTQDLTLNQIEGMYHLGPDYKSFFYESESSEYFNSTNIPQIAEVLDGTLTDKILFCLNSKAIKENICFNQSPTNIAKEESAVSQIESCSISLINDIINCLGGTKAFFSLIFEIDELFEEQDSIEQLLIFQQNEEDLDETKPEKSTKQKYNLFDDPNVFLDEGQFIHNKKKKNNENIKDENQKKQKNFLASKFLFEQLLEIICDVLLINPDFREDMMSSHGFAIFSNILKRIHPKFFSNKIIQIIKTLMINIKDLEFQKELKSYLVFDYSIWIRCSFDIQNQILDLILSCLPTSSNTKIEHSNSTTNFQNYENNSNNSNNLEKTENTNTEQTEPTEISDQKIEDNFIPDITIFDLLIILRSYDESLFRIPTVNQIPKKQTCGTKKLFPMIETLINNSQSIEEATVNFESLLSTCFLFNKQLFTEETLKLIKKFVTKNTKTFFRPLLSVGLFHPFIQLIQQFRETSIIYSCLLLIHHLDSFISENEEFIQEVKKEGYKFDNLENIYHYIHKILIEKANFHSDHILEILFEIFIGKFTPTDNSPILIIKNPFVLKTICHLANQKPTATVTQILRNLLILVSESKLNKEKIISQFAWQKWMVELIDYDVQEKEDQVFTKKDENKNKKTSFAYEFIEDENEILDDKKKSVKHGKSSLNIENQTDYLSLDPFADLEEVSEDDEEIERKKQREENQEKINQIVYNILKSLFMYCFQSLDQKFPELFEQMLSFISLIHVTTKKLIAKIIRRIISDIVVEVIQSINQEKQSQTTSGKIKRTNFITNLFYLINVLNAFLFNISEKGFALSNPQRTISNQMITTKVSPQFSRIRRNATLSPYTRNQGSKRNSKKYHRNTTNSQTFPETALESWKPKFYILETNFVQNIMTLLDEAGFFRKKGIGSKDKIQTRTIYKIIMLLILFTIKKADCELTEFLLEYLKNMVNNPLNYKIPHVVNSQELVTISFAFLFYYLQEMEDEITHKTETDSEFEQKSKLQPKQSGIFEISIAKPLDEPKTPRMSQKNIESISIDPQFDQSNSDEYQTKRKIIAKYLQILMQENYNFLVGLFTNENRDRSLLPIDSRNSFLYLNQDIEKFIEVLSSSQWKTASRNVFSSVVNQIRFEIYQNGLEFSETQTNNVFHLRDKLNNDFKIQQAQIKSISLHVEEKIVKMIKREKKRIFNSEVEKGKKNRIYFQEFERMVENSISEKDLWSLNTTNLSEQNNQQESRTYLKLEQREDALRRRKKLKVCFRGSKKAQQQEEDNKKKENLSNLNRTFRMKSHRNFSFIDQPNLRSGFSRFLSYETHENEREQTSANIIMKTTCMIVTISTKTIGTFEITMSSIDFFVDYNKNEEENLIEEIHDKDYSWNIQEIESIHKRRYLFEHTALEIFLAKRKCVFMNFANLEERNQVFNMIQNHKLANLKDQKYDYSGDDPSKWIQKTQFTKMWQRRQISNFEYLMHLNTLAGRTYQDFSQYPIFPWVIADYESEVLDLSKQETFRDLSKPIGALNNRKKKCFVEHYGSGKRKIHEFNHESHYSTPDIVLGYLIRLEPFTSILLKNYDGYLDRQYQIFSSIPRTWKSLLENKSNKTNISNVSELIPEFFYLPEFLYNPNNFNFTRSGESWRKLSNVELPKWAKNAEEFIRFHREALESEYVSKHLHEWIDLIFGSKQRGSSAKNAFNLFFPGAYEENNEFDKMDEQQKQIARMQIDLRGQIPMQLFTSQHSKRLSQRKINRVFFDWKDISQTKSLRSYKLEVSTTPIIFSGFFHMSNNVAFTGSSDKIITMDKERIIGNHRWVLVESKTSTAPFSIELDTALKTKTSAGVSFAPDIRSFSGCAAIDCNARFIICCGFWDDTFKIFSIENSKMTQSISRHKNVVTCLALDGEYLVTGSRDTTVIVWKYDEKEGKVYEKPKHVFLVHDREVNSVDLKTRFDIVVSASKDGSFIIHTLHKGKHIRTVFPFEKHPVSIIKISNEGDILTFSDSDMKLRLFTINGYLLKEASCAQVIYSLEITPDSQCVVFGGREGIIQIRSLVDLKLIHSFELNQIIYSIVIASGRFMIVGFGEGNLLIGYFVPNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7R2</accession>
    <name>A0A9Q0R7R2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plastin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7R2"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="115"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="256"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="834"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="382"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="458"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="632"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="948" mass="109402" checksum="AAEECC93D318215B" modified="2023-09-13" version="1">MANFRSKIKPDIAGFYSDAQLNQMFQNFKQFDIDGDGSITVDEIATVLDKIGEHLTKGQIERILDAVDTDKSGTIEFPEFVQMIHEMKGKKIGFAKYAEKVETYGKIGRTQEYSQEEKEGIVDFINNSLSDVKAVSDIIPVNPKEDDIFTIIENGILLANLIGKFFPDKIDLNSLIIKRGMYSQGDLSKNLNLVFKSAKEIGCKVNLKQEDITGGKKHLILSFIWNIMKTILMSLVSKSPISKVLNPQGAQWGGDLPPEQILLRWINYHLRQSKVTKFVTNFTSDFQDSECLIYLLHSIEPKKCTLMPLNETDLHRRADLTLNQAKNLGARKFLRPHDITNGSQRLMTVFLADLFLKNPGIQEKSEKDTELSNKLKEFEVILKQKTDSKQKIQTKIEDVRKKLDFQLQKKQKLKEQLKKIQSQLASTLSEQERLSLEKLDPTGIGYITNLQDIVMTKITTLNQSLEKSKQEKERIQQEFMREIQTLKDSYQEAEKCLQETQSSMKQIIHEGKQEQEVLSQQLKELVTEVTKLKTQKDSLEKMKDLDETRLKTQQQSMEKQVMVLKSEKITLEKETARLNEDLVIVKDELDRRKEYVKLEKSKISEETKSLEQILELNQEKMSEAKQTSKANTEALTTVLQELSEELTQTQTESEQLVEVIQKTEVENTEERQKIKMNLENVQAEQEALIQTIKDLDKELADTTQESEEIIVKAKQENDSLETKIQEMEIFAEQNEKEKIELITETDAEKERLAQEAQELEERLDNLEKDIDLVLGGTGSLQERLKREIEARNIALSRAKLDKERALMAAERDKRQILSWVEGSLGKNDRATWCKLREESQFRKIKWSKKWVVFKASQLAILPDKTVNKPEFVFHMDEARALRIDKASAKKDNCLQIKAATASIIFSLSNDKEVEDWFRVLRAARKSSEMQKRVMEDKAKQFQQTFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7T6</accession>
    <name>A0A9Q0R7T6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radial spoke head 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7T6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052441">
        <property type="entry name" value="Armadillo-Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="585" mass="67645" checksum="FEAD648CA2BBE0C6" modified="2023-09-13" version="1">MNYLWKITSKVKSNKKVVVASGVAIGIVGYFSYKYFSQQNQIMEIERITKIFQNEKESFQQNSKEIKLLFESIKNLNDSIPNELIQEIISTFSPLITFENFKTDEEACYFLFEILQIFCSKIDSVKEIKWDDYILSISKNMDFFIQQKQTEPKIADYEDYIAKGIKILAEIVRITQKRENVELILKNTQKETFYKLFSGNQVQISIEISKLMTWMSEYNGEVIKELTDEKFLVKLIEFLSSENEELLANICSLLRDIVLNNPKTIPIIMKNNTVNILKKLLNSKSIEVKCDSSLALSTIMKKCDLETSEFDADPNLLSIILNNFFSEKESAKKSSLIYSGLELIYSLALQSNKNKESIRENQFFPYILRCLEIRNQRINKLTIRTIKMLTTNSKVTHNVDEFLNLNLLEIFTAIIPEIKDDEILSDIEAIIGDVAFLSEENRRKIQQIGLFDFLLQNLFSKNPSVQSKSVCAIANCLLSMDLQLELLKNNLLPQIIELLNSDEPNSRLGAMLSVRHLAVLGSDPPTQIWAENASILSDLHILTAFVRLQEKEPKFQQWILESIFHLSKHPKFQQEIQKYTSTFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R800</accession>
    <name>A0A9Q0R800_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R800"/>
    <dbReference type="OrthoDB" id="10480311at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040408456" evidence="1">
        <location>
            <begin position="19"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="445" mass="49515" checksum="A7FCDCA55252E4B7" modified="2023-09-13" version="1">MKLINLLLILFFASNILCFELTQQFANQKPKTKFTNDIDYIVQPDFELSDVLSWVHNEPYAIFKRVNFLDHDYVVGSTSINPPPTAMFFEIKGSGNPLWELGSKPEPMTTVLTDAIGSINSQALGVSVNVQSFKQGVVPNLTLSKYTANTTDQAPPPDWEYTVTDAVIWDYDSVRISIEGEYLIWFITKVDGTNLFHAEIYTFHADTGVLINKFAAPSGTSAIDCEISHDGTIALFNDREQIFVVHAHTGEILWTDQLNPADNYPAALSGDGGLIAYGFEELHIIANNGNNYTELWSINGNYQKYCAAVAISQDESKIFAAWTNSQLNQKWIEVYSKESSTPLFNYTFPQKPGKFQDLPYVCKITYDGHYAMVGSWGQDGGIVPTIALFDLETQSLLYNYTTPGSVFAADIIEDGDSLYFSVGTKSVHANTMGYGGSVFTFDYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R919</accession>
    <name>A0A9Q0R919_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R919"/>
    <dbReference type="OrthoDB" id="525027at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022709">
        <property type="entry name" value="SCAI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21243">
        <property type="entry name" value="PROTEIN SCAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12070">
        <property type="entry name" value="SCAI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="784" mass="91919" checksum="5380CF2D5F5863B9" modified="2023-09-13" version="1">MGNSKATLVSITTEKRHKEYLSMVSTSSEAILIIDSNKNLIEINNHGLSLFHSNSKTQIQQQIQTWATESQPHLNGQSENLIKTICEQIIQSKSVFYETDWKFVDTHQNPFWVHFWLTPFLLFDSFTLQFVIRKIEDPQENLDQLHQFTDGGPDSSLILFQNPKLFKKKSYPFSLTTQKVTQQQIAHPVASKFRELQAKAQQLFIGLRELPNYNHQSYFTYLMTAFQAMITLWDFAQQNRVVLEKPETYNLKRWEIGDIASKIGQLYYHYYLRTSILSYLHESYEFYKMIRFHGYYNNVFEPKDPTLVIRKMRYLARFILVCLLTENISSLIEVKSEMKKTVRAYEQTFQLPDSQEWWTVLSELDQILMVNTMKYSSKVEQMIQVSYRLHQNYFSVYHRINKSLYSIFDSEPRYHLKEAIITGNKTQIKFSEMLVDLLRFTELLEIIEDKDPTELIQSPKYKCPHKLLLYRPTISQFLTTLSSTTSILESYEENSALLLYISAEGFFSPLANIGGAQLNPTFRDLNSFKFDSIPPNVLSSHDLLPFTRSPCLLIVDSSSSFVFQEIPPIYGKSFICLSSPQNQFPGIDPIEGGIFTLFLTNPIYAICKITSIRIPQEQFETAILLFENTIQKLIFINLCDLLQNLYQEFNQDQLMFSRLGISENDSIEKQTEISTMKLENHANDNLVIQEENTVSNNQSDWEKIAQFENLIVLVRFLDDPFFRTIILRFIFFEYICKTHRELRSDPDYWPKSTFRLPNDFLNNPKLKESVEKLLSFLDCSHHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9N5</accession>
    <name>A0A9Q0R9N5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nf-kappa-b-repressing factor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9N5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="433" mass="49437" checksum="7DE9BCDD39975883" modified="2023-09-13" version="1">MNENTITNSNSTSTLNINSTSNLNSNLNSNLNSNLNSNLNSNLNTNSTLNINSNPNSNINSNLNSNSNINSNINSNLKSNSNSNLNTNSNLNSNLNTNSNPKRTDSQNTKNNLNSKELYQRRKTQYKKKAKQKKSKKKSNIIKANFINLSTVERFSFFRKTFTKIKIEAQQELHEGISQIASAFQNVSKSLSKKIRISNKQEQIMESTKYTVEKQAQIANKLTQKSRQNEEFLITNSKKTYQAAQKIGNAFMKGIYCDIGIDFLVILLNSLCWCLAESWIKNSSQNPHQTKNINLFKLRSLLLLFLSTFKIMVETIIFFVFDGVFSVFKRYFAGARFQTLPEFATIISVLSVVYHSLQEAKKRVSMKDKFRTFVKCGIELIIELSFLYLFSIWVPIPGFSVFIGVFAAHIVNQNKVKIFGFFYEMMKSEENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAU6</accession>
    <name>A0A9Q0RAU6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAU6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="174" mass="20884" checksum="AF82FB312ECA1A49" modified="2023-09-13" version="1">MNKNKPIKKIRYFAGRIPDFAQNSNQKESKNQGNKTEKINQERINEKKLIKEEEEKEKEKLKKIDSRLLRLQKFSSENKKIEENKKQNEINIQNEDDNIKRSEVENIKKTEVKHGRKIHKATIIKKPENKNENQNKNQNQFKNENQNENQNQNENQNQNENQNQFKNQTKSKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB38</accession>
    <name>A0A9Q0RB38_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-binding protein 9/10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1790"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2343"/>
            <end position="2383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3121"/>
            <end position="3214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2354"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3126"/>
            <end position="3159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3167"/>
            <end position="3180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3181"/>
            <end position="3205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3614" mass="419523" checksum="970B7C3C1F612A86" modified="2023-09-13" version="1">MNQFEDQIYNEKKKQKLPFGKCRKPEMFWGTLDLNLLFNSTLINEEIYFLAEKKKRKNTEEKQKIFNYQINKLDLYKQGFLHLIPEDSGETSNIQKYSFYANRALQKLVSKQEYQELFSIQKTLFEDVIAAQIAVLQRYNEGLGLFYRHLEKKRRKKYVQGLESEWNRNQDHKNTNDHPVDPIMQFLVTQIFGQKEDTLDKNLAGLLRAREFLKTQNALSLANVDPFVIEELREKAVKCIVAHFSSQENETVFSTCLDALCSLVYARGSLGLVLDLLMLVYFPVEFIRMNSSDFGFEMTNRRKKGFKKQSRKKKNKKKNFLKRIQVKSLDNLRLFQKHTKKTARKALDQQKEYNFIPRMEGSISPIKGIMGVDNTYARSGETSNQQAHLRYSDGITNGISGTRAAKTSRISFNFDSKLTTTNFIQKSKILEITDSQKDRLEYFYHGLQEYNQIHEISLSTMQRVDGFRLLAEPCIYPERNKTPRIETLACDRGFIYLHDNKGLLKVGKGAVGTTKGSVSARIPFYNSHEKGWVVCVSGAIYYRSPETSPCTLIEINPETLEIKGEIKQSGYGAIKSANNSTHFFGPENALMRSPMFTDGKLLYIIEQKYSLARKRMRYIVHSFSPRNLAFQKKLALFEVDENECREKYCIPFDTRYFSDIGFYSDGLHLVFIFHDIDKYLNSFDFDDNFDMKNTQKNSQKNTQKNTNFNSLVMVFCMKTGIKLLQQKFLIEDDVSGCLCYDSFANIVWGYSSSLMEMIAFGNIQTNLRGSPDRSHVETTTIFPHEPEKPTQKQNIGVFMVDLVERLIAQHKQTLLFGMNCNHEIHFVFDPKNVERNIERIVQMIELCVVSKDERLLTTFLHLLKINIDLGGQQTRNKNREYTKTKTSVDYQIRQKTERFLVHLAMTYKGPSTRKMLQEIFRILFVARRGFFKDEKSLWLVKMASNLGDKGEHANAFYAACMEQIIHDGAWFVDAHLVAPVRVHHEQVLKTREEQKNARLQMTEPSPIAIHVSGTIPDYQRHQYMLVQKQDENIMQGIILFFSCLVRYAESGDPCGRSALQIILGDILRRDAKQNSTLLLALIQAFLRHFTQTMIQFSRAAKSSGEKRVASLQSQMEKWINDSPGGQVVQHVLVAILEISRHHDIEFAQGIVADLVAFIKTLDHCNIWMQFGDDHNNIELIRIWKVYRGISTQKIFFTAGVEHYADFDDKQQFDENTEMNPKTKNNKNLKIITIPGARFISIKIYKNQYKGSVTIRAMHNGEIVRNVKIKKSQKVNGCKLIFPGDSVEIEFGKTEKKGGPITGKIIGHFTTASSRNYEELILFEAVACRGLGQILQNLILGDGDEEEQSRQQVTIEVMRRQNWERIYIQSERSRSRTRAFDTITNVLPIINCPFMKDELMTPIKSALVSLGMANRPSSEYEHCNYLSRLEVCDPNLKTHLRTAFYKMMRSMLNYASKTSESALLRRLCLSVLTLKFPRKDHFDLSEIDIVGFLRSQINSMVGMQERQAMTSGEPLIHPAIVNEFYEFQSSHEISFHMEIARTFLLIGMVLFSARKPETQSEKKSKSGKPKKSKKSVDTLSKIQESYYTLLLDRLKDSAKILCSFFGFHKIKHLYALSEIPLARQRLANKEIISLLVKMLKFGALRTQVLILRLMRRLLPVVDPLSVNLDIDCNAVLHFLIRALAALKLRGSTILFDPQSNPKHPFNLGIIPQIAKFPQREFHEFSSLTTPVFPLISINKQKYKNASARYAHFLSTFFITNTHPHLLCTELQIHPNLGFCDFVYSRLPSRWISSTLHIESSLSLILPQISNQNIFPNSVIPVPNSYFSVEKDPSFQNPEYSQAFLRDPKALKSNEHLAFANYHIPQAIHTFYYEIKIQNEDKRRELISERSGKFTQKTSQNALHLCFGIAAVRPTLSSSRLDTDADVDEADIYCEQSSWYLFDAETGSKICRTSSRHLSQYGPAFNVGDVVGCGIKQKEGVIFFTKNGKDLGIAFKNVSGRFVPIVLLGSFGLKITANFGSKQYFFDFENYIQTHIPKTYNKLVVEYTSRVLIGEFVMTLRSLSQHKRWSHYISEEMRNPVNEISSQIAKTEGNSQINPDKEVSFAKFLMNLTTTLLVLGAYTETLRLGVSVDIDLSGYQNELRLNSVLDKNITRNTFNIKNTFHNRNMHNHNHFNRKYPRDFSRKSHQQHTNLRGVVVDYVPGNLEAYVLIVDADPQDPIFDVGQVVTLSVNSLIPKEEFPRNFPEIFPFDSSTVEALEPFYAKTHTQFPTKYWPIFFQIQTMVLKTLYRNANNIDISKIDTRNLISFFESAFREPPSPNLDIRTAEFVLVHLYDKHIRHNLFTPSTPKSEKTVSRQQTNFTKSENNYSRSESFPKSESNFSRSESFSKSESNLISKESNTNQNWEKIQVGDFVYVNGVTQALESQTFIWNWNSEMITSLKRLGIVIRKHDPTRTILLCTFNHDDMRLEEWWYRAEWLLLANEDIVEKDNRLSDQYFILKILKLKSEASCHITDHVNSLLCILYSRKLVLRLLANNIASPAHFAFRVFGVSTNIVPLFKISLLADKNRSDNKHYNIFRTALYFILQNAETTKESHIFLEKLFHEFYIQLNPVVKRHEKIHLFEAKFPDPKPNSQVIIDDRLIHIPKSSQILVVFLSQTQLIPGKEALYLFHAGGTQQNALLSIMTGSGLGTFPRQIINNDRFWVRTVLNYPQLLHTTQTFTSVSPSNTFLSSPEIKFSTQIIKTMSQLKYQRERAHKPSRGYRFYVVTLQKRISDKENCLRFSEQYILGFVRLIHDFPFKMASTSYFFSDESLLQLLESRIFSVETRIFVLQALTSKIRAQISIYNHQVSHPPNSVFWNAFWKYLPELDSIFQEENRLATSDPNMIHSDYVKTLTDFLIHIHHLYHNIFHFSNLHQDIDIVWFRRLVSFIFSLENRIAFNFSFHNFNQPSPLSSDFSLNLQTCEKLFSISDFINIHFPDLPLSSSLKFTELIHTMNGNISWPFSCTLLVNSREVNAENDILFGFLIEFNRNILEFFPVIHFIDQSFEQPNLFEIWENYSSYLYSRSPTFSPKTSLSYSHLQTKPNSQFIPKSNFNPVYNSQKNNQQSIPSVFNYQAFQTQNNTNQPSIKNQSKSFSISSQKSSTDNNNNNNNNSNTNKKSWLNFYFPDNNQLQNSTRNPNMLNLKNTNIENTNIKNTNLENTNLENPKSPKKQSSNQIMSFLDDDGIEDINLYSSLPESDSDSGTNFSDFIYESETDIEKSIPNRNIQNEIQIQIQKSQGNSYEKQKNLLRTENVQTQISEMIHRPNFSLQNFSNKQNSNTSDIRGYENHQIINQVNSFQDLNYNLIDSQDEPLSEISLFPRNNSQFNISRQARLQTSFSEVFSPEYIRKLGFSQKRDSNQQIDKEEEQQQKYQIIQNIQNQIPQNIQNQNNNIQQNSQQKYQIIQNIQHQNSQHQKYQIPQNIQNQNNNIQQNSHQNQNNNIQQIIQQNSNPKYQIPQNNNIQQIIQQNSQQKYQIIQNIQNQNQNQNQNQNNNIQQIIQQNSQQQKYQIPQNINIQQIIQQNSHHQKIFNKIHIIKIFNKIHNNKNIKFFKIFNTKIHNIKNIKFLKIFKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB94</accession>
    <name>A0A9Q0RB94_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tho complex subunit 3 tho3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB94"/>
    <dbReference type="OMA" id="WNADGRH"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25174">
        <property type="entry name" value="Beta-prop_THOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="323" mass="36461" checksum="561382DA6952C583" modified="2023-09-13" version="1">MSFKRISKLLKHYSSTNQLKGHKKNVHYLAWNLSDKLASGSGDLTARIWAPDSSRYVCNLVLEGHENSVDQLCWSPIELDLLATASGDKTVRIWDTRTGKSNCVIPTTGENINITWSPDGKSIAVGNKSDVISFINVEMQKITKNTRFPFEVNEISWDKSGQYFFITTGRGTVEIFRWPSLEKVMVLQAHTSNCFCIDFDPTQQYFAVGSADSLVSLWDLNELICLRTIPRLKWPVRAVSFSYDGKLIASGSEDKFIDISWVENGEFVTSIPLEGGMNSIAWHPNKYILAYAGESYEQGGVIQLYGIFDQYKNKHSNSRSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBC7</accession>
    <name>A0A9Q0RBC7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBC7"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="141"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="246" mass="29083" checksum="53623E1AC701EE9B" modified="2023-09-13" version="1">MSSPTENIEEKNSNLKENIEKTNSNLKENIEETTNSNLKENIEEKTNNNLKENKEEKEDIKEWNSESFEDLDFEVESISENEKSKEKSKEKSNQKSNQKSNQKYSQIERIPVHYTESQVVKIIDENKKAKEVIVKRKNSLQPLKEGILNKKSGRLQRWRTRIFKLKNDGMYYFVNQKKKLKSKGCIFFEETFDVRKCTDEEEKKIGRNFIIKILTAKKSFLLQCADGNDRDSWFDAIQNAREAVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBR6</accession>
    <name>A0A9Q0RBR6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBR6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="226"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="330" mass="37750" checksum="83E6D5532457D4DC" modified="2023-09-13" version="1">MSIDKAFVTGLKKADEEIVKAFCESGAVNFVDNNTPLHYAVINKAGPDIVGLLISYGANVNAQNLDTPLHYACWIRAGSVVIKSLLFSGADITLKNNETPVEAAIDGETKDMMKLFSLLIQDMIILYESGEMIDLTIQCKGGTVEAHKLVIEMRGKNCFTLNEFLEFCMEYSQEEVKQLLRFLYTGIHSFSTKILTEFQQKLKFTKIGKKSLHQDFLRLYNDEETKDFSIIVGDYQIKTHKLILFARSEIYRAMFSFVNDPSPFVHDYSGKSKEAVSAFIRFLYTDSLEKDLSLQVVDELEDAADYYQLRSNVLFQHQLRKLREKFDQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC06</accession>
    <name>A0A9Q0RC06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA recognition motif rrm domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC06"/>
    <dbReference type="OMA" id="GTITSCM"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="102"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="194"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="521" mass="60671" checksum="B0212BA785922D23" modified="2023-09-13" version="1">MHKHKHKTQTQTQTQTQTLHVGNLPENVTDQLLLQLFASFNPISAKVARDQNGKSKRYGYVSFSNPKNAEDARENYDGGEYNGHILRVTPKIPINKLKSGKNNVIVKGLKKDWFEAELREILSKKISNCDIISIKVPRTQNKESKGYGMANFVSEEQAREALKLTGEVIEGQPIEVELYLDSEFRDEQSKKTYKRIYIKKFPENYTQDDLQNLFQQFGKIDKIELSKFGNAQIPYAFIDFSKHEEAELAIEKMNGKRIGIQEIFVGRAIKKAERNRFLAQQRMRRPGLIRTNTIKFVFINNEKIMMFDSATIREECLKIEPKPQIFSSKVFYNKDTGKPSTGFVCFETTFDCERILRFFQQNPHPDYQVTKHEPNMHPNPQPRGGYYPRQPPHFNPYSQGYPPNQYPPNQYPPNPQYQRFTFDQSTNQQPPIKNPHPNPRSFSPNQNPNPNYQPRPYQNYQPRSNYSNQKFSYKQPNKNQNQNENQNQNRKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD06</accession>
    <name>A0A9Q0RD06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD06"/>
    <dbReference type="OrthoDB" id="18783at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040112615" evidence="1">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="36068" checksum="4F6CF3BC9A310FB4" modified="2023-09-13" version="1">MNKIVLGVIILTLIIITATFASEISFKPTKVGRTEDKTIGYQIHSWDDLREWDSMFQKIQTRTETEIWLKVDFSYINENRSKLFPNCYSPSNNGCFPMIHDSPIEGNFYNTSYDLLQFISSPKNIDLFRNPNFNVFIAVCFKFDNPCLESTPDAQSWLFLVDEFFRNATQIIDSNSLNLQFILDGASTPGGAILDLFSHNLRICLAEKWRPLNATYISSNDPLEAIYSNEKNIFGFDRFQILNQEILSESPLFYVDFIMDLGYAKFNESIYPFLFWEPSDQVTINTVQDALLSGIPHSPGFQIRNQYRPYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDN3</accession>
    <name>A0A9Q0RDN3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDN3"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="101"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="272" mass="31874" checksum="F4BEAA912C39A380" modified="2023-09-13" version="1">MDNNNNNNQIQNANQNQNENEMKNLEKKGNKIKQILAKLQAKLQIKSISPISKFSILNIILLLPLIYIHIKLWEKDKEMIKIKPIFEKYFDFDHSFSNSEIIKDIEYVKKLQEWINDNDFFSKMKKGYSAKKDGFNSHDWHNKVDNKGKTLIIIQTKDNFIFGGFTSVGFNGNKGRINDSNAFIFSLRNDKNDRKLEKFPIKKDYAIFSRLDHGPHFSCDFWLNSDLKPGFSNIGCSYNTHNGIKYDTDEAKSYLAGSYNSWEVYEIETYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE05</accession>
    <name>A0A9Q0RE05_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE05"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="151" mass="18308" checksum="7F6D1BA921FDC00F" modified="2023-09-13" version="1">MIYSNRIINPKLYSEIKEIINSNEKIEEIMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKEIINEIQIGIDYFQLNQTNPNLFDLLIKNLIIKFNNQNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE39</accession>
    <name>A0A9Q0RE39_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_00581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE39"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="181"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="464" mass="54434" checksum="60A3795190DBEB4C" modified="2023-09-13" version="1">MQNQRKRTNNLDNIQYTALNQHSSQTQIKSQLAVQNENKTENQKQINPSKQSIQEKETKEVTKKEFCNLNSKKQNLTIEIKQQKPIIKKINSIKLQDALPKLNECEKSPNYTPSTTYNLKSTFSMPNLANTKNFDNSFPCLEKLVLSLTKEEPSELPTISPQTLLKVLNSPKSFNFDYIFVIDCRFSFEYEAGHIKGAKNWNDPFKIITNLFSEQIYENACLILHCEFSKNRAPSMFHFIRQIDHKCNPYPKLFYPQMYILGGGFRNFFKMSKENKEFCHPKEYLKMRDKDHSNELIASNNELKFRFQKITNFLQQPNFTIENLRLFCRKNKNLRVARSFSQPELNMEMKRHRSSNSHPQLMRSSSLSDTPKFLAEMKVTDLHEERLSKSARIEEKFENQIFSCRSLLHSPNSQVVPVSKRRLFELSSEGNSSFSSLYINYPKDHKVKTRDTNDLSSIYFSKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF84</accession>
    <name>A0A9Q0RF84_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btb (Poz) domain-containing 2a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF84"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="118" mass="14236" checksum="D7A802E298B84942" modified="2023-09-13" version="1">MNLNQLLDSSYQFIFQNFEEFIKTSFFLELEENHLNSILSNDIIPINEFEIFQSIIKWGKYKSNINQEKELDKKEKENLQNQISNVIDKIRFIDFSRQELEDILKEDIIPNQFSEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGK1</accession>
    <name>A0A9Q0RGK1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ring finger 10 family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGK1"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="315"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="695"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5079302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="724" mass="87027" checksum="0AEDD821ED0C33CD" modified="2023-09-13" version="1">MKNLKYVSGISAQETLDFIEEEMDFEDFSSFHNWKNYENRINRKERQRKSIRNFSRSSFLQSKFRFCVDEEFDFNQYFLDPDSEINWKHVKMTYLIDPEPICPICLQKPLAPRMTKCGHVLCFYCLERYFLTSSNNFQKCPVCFDLIDKKSVKICKILECKSFQIGDEISFQLIQTHNNSNLCFPFSITQINPSFNNSILLSDSYLDISKFNKITQFSVQNIINLFLENENDMNLLESEAQKENLPSLDLIQSFQLKLKHEKEKFISKYLNPIHLENQIQIQNQIENQNQIENQNQIENQIENQIQIQIENQIQIENQIENQNQIENQIEKKKRKEEKRKKKKEEKKLQKKISQLQKIQENQKIQNEKIHLNLSNIDINKTEDFSYFYQSEDGQKLILDYLCMKCLEEEYRNKALPESITTKITDIQTKVQLLDFEKRHFSTKHFGLGTEFHFIEIDVKKLVSQKTWNLYSEKFKEREIKKMRRKLIENQRQKLIEQKIRRKKEYDLSQSKAYPLFTSFIPIETKNIEKTIENFPEILDSSKNISNQSNNQKPNKLPEITFLDVALNSEKFQEFSKKNQNKQDQKKSKKQIQKMNTKQNQIENQIENQIKNQIENQIENQIENQIENQIENQIENQIENQKIENKIENQKIDDRNVRNTSNQIANKNKPQNKNKNNKNHQNSYYNKQRKQNQTQKIHKKKFRNKKNRKKNQKTKPKKKLNKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGM7</accession>
    <name>A0A9Q0RGM7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat and socs box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGM7"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="316"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="489"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="69825" checksum="92A72309811B50B5" modified="2023-09-13" version="1">MNIWKVIEENNIEYLKQIRNIPENELKNGNNLILNFAIEKKNQFGKNSLHLICQNQNISFEIIKLLIEKGIDINSKTNNNETALHYAFEYNSLEIIQLLIEKGIDINSKTKYDNETVLHYACKNQNISFEIIKLLIEKGIDINSKTNNNETVLHYACKNKNISFEIIKLLIEKGIDINSKTKYDNETVLHLICKNQNISFEIIKLLIEKGIDINSKTNNNETALHYAFEYNSLEIIQLLIEKGIDINDYNIYNQSVLSLAIRKQRKEIIQLLLMNDANVFDLTENQITNEFIHTFFEVYSINQDLNKLLNSNDNFSDYQIQSNDGFKFNLHKLILLTRFDNNETILKKFVNICSKKSKEYVEFILNFLYTGFLNFQQIVQKLDQNQNQNQNQNQNQNKNQNESISVISHSHYLNVWDSYYDFSTPLSPDLDEDETQIFLKMNKEPSKKEKEIKEFFKEIGFDSKWFETKKGRKGILKDFHKLYQQQTTKDFTIIISNENEEEKEIKVHKLILIIRSELFKGMFQLNVQDTSNKVHDYSRKSFETIQQFIYFLYHDKFEKEINSEIREEFEDLKDYYQLNQDSIIDLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGW2</accession>
    <name>A0A9Q0RGW2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Muscle-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000028">
        <property type="protein sequence ID" value="KAJ5079539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGW2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1275" mass="150392" checksum="DA7D40B5F4986836" modified="2023-09-13" version="1">MNKNLTFKIYSLSQWFQSITQNILNFSINDTKLSQNLCELINKIEPNSIKEIFESPKKNYQSFINSCIKYGVSKEFAFKPIQIINQTEKEPLIKLLFELKKLYQKKKNLKFQENLFLSLNENENENWKKDLDSNLNSNLNEINEFVPLKQKQYEICSSLIADYFVKGNVKFPVKVIYSSPTNLSENEEQEIDAILYFDRQTIQILIFDEPFFAQKYLVNQQFQILLNTEKENEFLFQIQDKTPILLKCESYIDRYIIYKTFMLFQTYQNPDSFVQIFTKFGGEILEKEKERKLLIKKLFSDGEVLFQNVKVIDKESNIKSVILQLEFDRLCILFETVNTSPFFIHFNQVFQVNPESTNEKNIKIEFGKTEIQNIVYLNCENSSARDLIIGCINEYYNEYQNKVKSGISLSLPTKTPTPTNTPNLTTPPPNQESIIHQPFKLDHFKCEIETQNSEFIPAIIHLKNDTLYIETDSDSYSDSYSNFDFSLINPQYPTMIKIPDASSQITLSLKFKNQNKRDQFKNIYNLLKSKYQSLESRFDSHSHFFKAQFYSLQMDKIAVGTIQFYGKTINFQFSNSSISRNIFNSNLFLTYHDLICRLIFNNKKHFVFGFETATMQRIFLLEYKKRKEYQFPQENESQESNEEMKTNEETENQFFVSQKFEVSIVNNERNLIEKATIGITDKNIEIESSTKRPNISFKDENLKIQTMDEYLLIKIKSEFNGDIIFKFENPNDFSKATNLIQKQKLRYALLSRDTFELETPKPPKLNRSLSPIQTEKPNFAKKEIQTETPSPDFISNENNLIEQTVQKPIYFEHEKYTSLTGYDQSKENIQLDFSILDSKKISNEINQIQKNFSQGSAKFNIIITNEKKNEEISAQFIMMETKFKVIKNDTSVSIIESAYSSQSKVNLHRGKGKFDFVLEFTETNEKITFKVPQLKDNIILWKTFMMLQYYSPSKIRNNRISSSILDEIEEINALIFKFWVNNNAIFNLDTLTKDEKYIPVLLKIDRNQLSIISTNFQPTYISWNDNVIDFYLDSSTHQIIKIQFSGENPESEIYFATKNEIVSELVYRSLFIFKFLCQDQFKKEKIFINKPYNFQIEKIESNPDYFLDFINSLPSFKQYAKFFDRNEPKKTLFDSNSQKSLQIYKSSLSESDEIDKIKQQKESQLMEKIQEKAKILWKKSPIVFQVQVIFNRKLFNGIVKLKKKNLEIRNLIFKTKMIEKWINLKIFADDFDEFTLIFGLKEGKNISVRFESTYDKKLCFSAISQKISQLFGRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHL4</accession>
    <name>A0A9Q0RHL4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHL4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="93" mass="10748" checksum="EF260F09F36BDC5E" modified="2023-09-13" version="1">MSYPFSPFGGNFNPPNRFGQQRIPEQQVFLEIQKLINLLKVSTNNEQSQLKTLIELAGKMIEYEVLLYMNQFNINEIQLNTSGAQNFIIIIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RII3</accession>
    <name>A0A9Q0RII3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RII3"/>
    <dbReference type="OMA" id="SNIMMEY"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="914" mass="105728" checksum="B1FE188EDB933E6C" modified="2023-09-13" version="1">MNKWKPNKEILNEVENLIEESKKPNTKIQKNILNKMKEMNLNIPDLNNYLAFIVCLYQETSITNRRNAGLILKNNILQTQMKDFQNVIEYVKEQMIIGISDPEPKIQQSCGIVISSIIQNFGIRIWPNLFDLLYQMIQENQNQSLIIGSLDCILKILEDQKNVIKTEFMEQNFELLIQKLLNYLHHENKTIQNLSLSSLIEFTLLNEYSLSKQIENFIHNLIVLAQGENDKIKRKVCHAFNLLLTHYSVVVEKYINEIIESIMKMMENDDPKVSLEACEFWFFFSQIEHLKHHLVPFLEQLIPRLLESMVFTSLDIQLTSNQLDGENFEKFNFYSEFIEERSKTKTSLNGKEKEGISTNNQNNKINDENTGFDGKQLEDEDDEDDLIEDDVNGEWNLRKSAANAIEKLSVVYQDELFGHLLPYLEHILEDEQVGWEHKEAAILSIGAISEGCLSAISQHLPKLMVFLAECLKHPHHLVRVISCWTISRYIDFLAVNLNYNSNSNDNQNQSFQNTSFTFENVLKDLLICAMDRIASVQNAACSALAIFIRSSQEKISSFLQDILEMINFSFQKYKKKNYKPLYLVITALCETLDTELSRTELMKLIMDPLVQIAQSVSDEDDDLIPLFQTLGYIASNIGAGFEPYLEYFWKRSLKIIDSYVIVNSTQNLENFGITKDDLPDKIFMFTSLEFLASIIEGASTNETVRNLMISDNLPSLLFSVLSDPEEDIIQSALALLGVVAINNSDLLQLHIKQEIPLLVFFLKSQNLSVRQNSCWAIGKVCFTFHNLLVPYVEHILEELQAIISASPCSYFVQNFFDQWSALLREIKNKQDKLTAHFGFCKLINNNISVVVSYYESIFATILFYQFPSLELLMEFKDILFQLQQLLIEVGEWDSFYNNINEEYRAILLNNYDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5J9</accession>
    <name>A0A9Q0L5J9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ist1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5J9"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="245" mass="28678" checksum="7496E9ECA964E1DD" modified="2023-09-13" version="1">MTKFQFKPQFCEIALKLAINKISILINQKIIEERIQRKIVERLFQENKENEKERELRNHVERLIQFDFNRDCLVKLKDNCEQILNNFESFTSSQDCPENLKFSVATIIYTSKKIKLQEFTELTKVHFKAKFGLPFVQQHLNSPHQVVKTCISKLKKKEVDPSTILEYLNEIAKSIQIQFNPQESVPYLIEEIEEKNKQETENDQMDGNSMIEQNDDENDDENGNKLLDPTSSDSSNNLSSDQDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6A8</accession>
    <name>A0A9Q0L6A8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000141">
        <property type="protein sequence ID" value="KAJ5066529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6A8"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="197" mass="23508" checksum="2727FE76F6F2F8C0" modified="2023-09-13" version="1">MMREWIRDPNQEVIKYMLSRRMVLIFKQGDPNQISNYRPISINNDLVRIFLKRIFEEIEPIWEYISYQQMGFRKMMDTRIAVLELQKKLKEIKEPYIISIDIQKCFDIIDHGLIRKVINKFISNNNIKKLLNEYYKGNGCGIYQGDPLSPLIFGMVSHFIIEKIKLRVDHIQMYADDMILLVKNSYNKVITKVQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6P2</accession>
    <name>A0A9Q0L6P2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6P2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="400"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="461"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="513"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="680"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="787" mass="89453" checksum="E7BBAF2463F2A6EE" modified="2023-09-13" version="1">MNSKTNSNSNSKSNSKSNSNSNSNSNLKSNSNLKANSNSNSNSKSNSNSNSNLNSNLNLNLKTNSKTKTNSNSNSNLNPNSNSNSKTKSNSKSKTNSKSNSKSKSKPKSKSNSNLKSNLNSNSNSKTKTKTNSNSNLNSKSKSKTNSKTNSNSNPNSNLNSKSNSNSNSNSNSESKSKSKSKSNSNSKTKTKTKENQNDILFFGLNSLPKLFKNKQDKITKPIQFEFENENENENENENEKQIKQIVSGDFSIIFLFENGKAIEYLNENDSKQNPQKIQIEENIQKVTVGSENEAILTIEGNVFAKGKVINPNNPKEFINISSLIEDKNDRIVQDIVSGGSSIYLLTSNENAYGIGSNYSGQLGFKKSRNTKKPILMMKNISKIFSGYDSKHAFLLNSNQELFVCGDNRFGQFGLGYKKKKILKLTKIQNIPKGKIIDIQCGYMHSIMLIEDENQNQNPKRKIYSCGDYRFNGLGKNENTYEFTEIKSSLFENDNIIDISVGRYHNLILTSKGKMIGFGLNDYGQLGTGDTNNQSIPIQIELPKLRFNGNIFNYHISYGVSKSFLYYSPSLSSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNEKLQEIISNKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIQITQEIIDEIQIGIDYFQLNQTYPNLFDLLINKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7I5</accession>
    <name>A0A9Q0L7I5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enhancer of mRNA-decapping protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7I5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="58019" checksum="5CC156A6D4DF0EA6" modified="2023-09-13" version="1">MQTKQDEKTILNIEEIENQQESKSKSKSESKSKSKSKSKSKSKSKSESKSKSKSKSESKSESESKDKDEKIILNVEEIENQQKLNTQSKREMQKQTTENQFESQNQNNQDLEELNRQAKKIMVETEEIQNQIKNIEEELESKNKELKLYIENPKNISKVLETSAQRVTSIYGSKIEKEGKEKKAILDSIVSNLPKITESQISTFQQKITSIPNSINTQFKEKIPLSVEKEKSKIAELKNQEKTKNSEFNTIQLKQITPFILKNIEEKLSKDIDAFFNQNIWRKSFSSRSQKFDIGEKIQNYKQKAHQSFHKIQKTLASKSRLITTEIQKTKREKKTKRKENTKIQQALDLLHQDKINEAFEFVLNEQDLFLLMNFCSQFHSKLFFLQNRITNQIVLLSLIHQLSFYFQANLNQNQNLNQNQNLNQIQKQNQKRALKWIRNCFIFLTPHDPQIFQLLKEALSPVKQNLPNKLSVSKKEAKLITEIENILDLIFQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8U4</accession>
    <name>A0A9Q0L8U4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8U4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="321"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="491"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="69445" checksum="38E54BCBEBB3322C" modified="2023-09-13" version="1">MNDCLFFGENEKPKLIKNKSYLIKKPIQFKFENENENENEKQIKQISSGRYSTIFLFENGKAIEYLNENDSKQNPEKIQIDENIQKVTVGYDNEAILTKEGNVFAKGRKILIQIIQNEFINISSLIEDKNDRIIQDIVSGYDSIYLLTSNQNVYGIGLNKFGQLGFDSKTLKETKKPILMMKNVSKIFSGNTSAHVFLLNSNQELFGCGFNYFGQIGLGESRKEETEIQKLTKIQNIPKGKIIDIQSGYIFSIMLIENENENENTKRKLYSCGNHRRNGLGKKEYYNTYEFTEIKSSLFENDIIIDFSVGNAHTLILTSNSKLIVFGSNSDGQLGTGNTKDQLIPIQIELPKLRFNENISNYHISCGYYKSFLYYSPSSFSNIEEDLIKLFERKEFCNISFKTKNGEIIEAHKLILKYRLKQNQNEIEKLQEIISKKSIKESNQIFEMIYSNKKINPKLYSEIKEIINLNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDDIQITQEIINEIKIGIDYFQLNQTYPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L941</accession>
    <name>A0A9Q0L941_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_12645</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="858"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="900"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1305"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1382"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1415"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1453"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1487"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="13">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="467"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5068059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1526" mass="174635" checksum="2462207D51AF6CDF" modified="2023-09-13" version="1">MNEILFFGQNNYPILLKNEPNKIIKPIQFKFENENENENENEKQIKQISSGQFSIIFLFKNGKAIEYLNENDSKQNPSKIQIEENIQKVTVGSSNEAILTIEGNVFAKGEYINSENTNEFINISSLIEDTNDRIIEDIASGHNSIYLLTSNQNVYGIGDNEYGQLGFDSKTLDKTEKPILIMKNVSKIFSGIYFDHVFLLNSNQELFGCGFNEHGQLGLGESRKEETKIQKITKIQNIPKGKIIDIKSGNFHSIMLIENENENENPKRKLYSCGRSSFNGLGKDEDTCEFTELNLPLFENDDDILDFSEMKTNHIKRIPIQIELPELRFNEDIFNYHISCGYNNSFIYYSPFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNENQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPILYSEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITKEIINEIKKGIDYFQLNQTYPNLFDLLIKKFNNQNQKRKKEKNKENLSLNFGIDKETLLGLTKFGGLSTQERLEEQGGVEGVITKLCVDPKIGLRLSETKSNFKKRREVFGTNQISNQSEKTFLSFFLDTLKDLSLLFLLFSSVVSLILGLKMKDSNKILIQEIIIFILVLVACLVITIKDYKKERKLSNLNQLNNFFEVSVLREVKKDQSAVINILSKDVNIGDIALLSPGVTIPGDGLVISANELEVDESQITGEPYSIEKDEKDNPVLYEGTQVTNGEGRMIVIGVGTNTQFGQIREYLQEKPEPTPLQLRISDIINLIEIIGLFSAGLALLVLLIPWIFKNISNPKGFISENYDEFFQIVLIVRNIFLISFPSGFSFITTISFGYSMKKLIKSNSLVRRLEACEKMGNVTTICCEKTGVLTEVKLDISSGYFFDQYFQEIPEVMDQKIINLLGEGMAMNSKVIWDGQTLVGNQIDGAIVSYLMAMKFPFFDFQKENKEKIVKEFPFSSSRKRMSTIFEKNGKHRIHMKGSPQVILERCSHYLDQNGNQHQLTEEKNQEIQNLIENMTNLGLRTLALAYKEWDKISNENLDEADDFEKDLVFFSVLGLSFPIRKGASNAIYECQRAGITVRMLTGTDIREASHFARKHGILSDGEVIEGKQLKEMSDEERKSIAPKLQVVARSSPSVKLILVKTLQELGEVVAVTGDGTGDAPALQQADVGFSMGIAGTDVAKESSDIVLLDDNFNSIVNAIISGRSVHDNINKFVQFQLTSNLVGILLSFVFVIFKKESPFNIFQIFWANSVIGNIAAFTIGQDPATNDILKQKPYPKTDSLFPKQMIHNILAQTVYQLFVLFFILYFGQSFLHYDISIPEQKLHLYTILFNSFVFCQLFNQINSRKIHDETKIFKGILQNTAFFISLILIVLIQLLVVNFGGKLFSTIPLSRSEWIISIAFSAFSIPFRYISLLIKIGNDSQLPKKSMKEKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAL3</accession>
    <name>A0A9Q0LAL3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trifunctional udp-glucose 46-dehydratase/udp-4-keto-6-deoxy-d-glucose 35-epimerase/udp-4-keto-l-rhamnose-reductase rhm3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAL3"/>
    <dbReference type="OMA" id="TIRMENR"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="296" mass="33984" checksum="27B0E24A1BE70606" modified="2023-09-13" version="1">MNQQNKIKILLFGSTGFIGKKVSSLIETDFPQIEIINSQSRLENTQDVAKELDLIQPDRVINAAGITGIPNVDWCESHKQETLRVNLVGSLALIDSCWKRNIHIIQFGTGCIYQYDENHKENSGNKFTEKDPPNFFGSYYSKTKGIFQDLLDIFDNVLLLRIRMPITSHLEDSKNLISKLIKYSKVVNIPNSMSVLEDLLPVMVDMCIKKVVGVFNFTNPGSISHNEILTLYQKFIDPNFKWENFSIEEQNKILKAERSNNELDSSKLLEIYPDIPHIKDSMIKVFERIKKSIKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAV1</accession>
    <name>A0A9Q0LAV1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAV1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="77" mass="9095" checksum="D579FD62115102E7" modified="2023-09-13" version="1">MDSEREIQLRRKKNLFKFALVNYLKELLNICLFPQKAYLVNFKTDEHMRSFEITDKITGQTKSEDDSNAGLEDIQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB03</accession>
    <name>A0A9Q0LB03_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB03"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="390"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="58370" checksum="C47462885FA6EBAF" modified="2023-09-13" version="1">MESESLLKQTLIGKHSREVRCLCADERYVYSGSFDNKICKWNPETNKLCWTIETDSYIFALRVYDHFLYAVGSFFRAYNKKNRKIRFEFEKNKSYIYDFDFYQNKVYRGGSDNCIREFDTESGKELRSKNTKFTIWSLRIFQDKLYTGCSNQRIEEYDIENLDLIRHFDCSTGIWGFNIYNNHLYFTESGKLIKYSLEANKRVKEFEFKNYLISNFQIDDIWFIGGESGVIAWDLSKDEQKYLFPGATAWGACGNKKRLFIGLTNTEIYTCDISQFFYYTSLLKDLKKLYKRKESCDITFKTFGGEISVHKLIISSRIGKDYEKVLEYFQSQKIEEANIFFRWIYTGISQDDQLINQILEDLKIGSFKELNGIEKVSKALEKLYKEEETKDFTILIGNKSIKAHKVILMARSDLYRGMFLNVDDKSNQVNDYSGKSFKTLQLLIEFIYTDKLNTSLLSDQVISELEDAVDYYQLNTSSILPTLIDEFKKNKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB25</accession>
    <name>A0A9Q0LB25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fmrfamide receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB25"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="309" mass="37066" checksum="A99D89E7F753E798" modified="2023-09-13" version="1">MSVNKSTTKITEEEFKKMIEEEKQKMKQDFFQKIKEIQENNLNEINIKKKEVKHLEEKLTRKLSDLEQAKEFRDQCLEQKRQLLQLNSHLKKQIQKLDDDINNLNRRNEILIQKLKEKNLIVNLKKPNQKPNQKPNQKPNQNRNRKSNQNSNQKQNSNQKQNSNQKQNSNQKQNQKQNQKQNPNQKQNLNQKQKQNPNQKQNPNPNQKQKQKQNLNQKQNLNQKQNQKQNQNSNQKQNLFENLFQAENENLFQNSNQDSNQNSNQNSNQDSNSHNLKKLTKHHSLQPVNRNVLNFFKDNDNQDNSLWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBV0</accession>
    <name>A0A9Q0LBV0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBV0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.410">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="17100" checksum="EE9AD646E44C73BA" modified="2023-09-13" version="1">MIISFLFKSLFQINLIQINQLQTIYKLITQGTAINTYSPGREDKCYPGIPSILKMKQKKKSSKKEKEKEETQSIQKKEETDKLIQNKNFKFKADSFINSNQTSDFFEQCEKSNLGFMKTKSFYSQETNFPYYSKSKIFAIDFEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCH1</accession>
    <name>A0A9Q0LCH1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bud site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1281"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="957"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1194"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="960"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1194"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1512" mass="174661" checksum="ABAEB6FC7228D254" modified="2023-09-13" version="1">MSRNNQFSTDTHSFTRSKTISFGNQPTDNFHRTQRLEKEDIQKVLTVIHKNIQKKTPKKKERKKGRESKPRIVKEKRQIMGKAAPDFTQAPIKPGKLTNSKSPKKARRKRPQTLNLSQGSRKRVLVVPESVSVPLDQQAISEEQIQIELKKLLDEWGIDPAKRQIIEGLSLEKKRRFLAMHQDEEDNEVEKSGMKTDHYLISPRHVQKKGFTRQNNLPQRPLSMKMKSKSFSNVLRHHDSQLVSSPQNLVINIDLLDNKKQLIGMNDNNQQQDIPDIPLDDDIDNLDPLDNMNSNENSQKSFMNYRTITSVSSDKMLTWMTMYSKMYKFFSQQCMKKMKLLIGIKGIALFYYVLSRLPETPFSFSKDSANGEDIPPLNNLGEQTKHKKRVEILKTLINLAKNSTFFSELATKADPALLNLEIETLITPVVIPLCLFDILRSYVSSKRKPQFPRIVDRQMDLNEIVELVRADSTPKDIQMYSLILLGRIATVIQSLHMNLDPDFCDSLKSFVSSLSDNSKRRLEFFDFDFDLFDKKESFDLENLAQINWSKRKTKETKKKQEKIIEETKRFTLQIKLPDGVVEAFLGQETTTAGEIIREFARRYRISQEIYGLFGSFEDGEWAKEEAPNPTIARNISIQILDASFLIDGDFIPNDSLISAYRDKQIQIRKLPPDNLDIILPPDPKDLQPRHVTFPVNTLVSTVLAKLCFELHASKQEYGLLLKIPKKVSRSELDGSFKSGIESTYEIQHVSFVPVEKNQQFGKAYPTLSADNAFGIWMEERKKRKLSSYVSQYHVGGYIFAKFQPRPGKINIIYPSIDKQTGEKTQKEEQLMVDFTTQIKILINEFCRIFLGLRSAKKFSVFQVIYGYDDLSEYDLTNEPNPYSQKRHNENTKEKGKQILELILLSDDLPLCLQEIKVGDTLKLITNIQESLETPIKPSVSFTSLNSIVEDANGLRRSQTNQIGNNNNNNDNNNNNLNPNENELQLEVVDIDKKNNSNNPQEENIDIDFEMNFSETNPDLIPFWDSYKGKGIVLVLEQDTETQNNDPLDETFSVERIKALSLNKLVEIVTSPSTIMGEFLDMFIELLPTITDDETFLQKMFERFEVPDTHPQNGNMFSAHEKRRIQSSVIRVIYRFCKSSLNKISHEVKSMIQNFATNILVTHNDRRFQQRGHQLLQLIRNGGKEETKQENFPEEIKDNGNFDKKEKCCQPKRSQKGAPQKTGPMKMVRIKEDEDFSSEDGIETNKNGGLFRQEIYIKDFPNWKPKVPKITSLEKLGFEDISPDEAARQLTSITFGYFSKIQTKELLNISWAKRSKKTLSPNIISMVEWFNHLATFVTCVILRYEKLKPRAKIMSRLIELTEQLILLRNYNDAMAVISGLQHVTVDRLTRSWELVPQKAMTKFYDLDNLTGAIGGFKTMRNELKKSPRPALPYLGLYLSDLTKIEELPSRIADSLIFWTKRRRMYRVIKELKSFQSVSYEFPQVPLIQSFFSSDSFIITESQMWELSLQFQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCI9</accession>
    <name>A0A9Q0LCI9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCI9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="483" mass="57675" checksum="302E857B570782AE" modified="2023-09-13" version="1">MTLIYYKKPHEKTENPKEEKVINQIVKDYLSKIEKVNFNLKKVNRYEFLISRPTESTTRNKKCTNICEEDDLKFGKISLAFEYKELKIIRLENATTFVLEYTNKEWYKYISVDCVHIAQEISSRCLIKFHLINKWNSFISKKFDYIYFFDQKQEEEERKKLNEKKEVLTKQTLKESMSSRKLLYLRQRNQSLRRKPFSRSFTIRNLSMKNFDPNNQVQNNQVENNQIENNQVENNQIQNNQVQNNQVENNQIQNNQIQNNQVENNQVENNQVENNQVENNQIQNNQIQNNQVQNNQVQNNQVENNQVENSQGPLLRRLRSEEVVELSADKWESELFEAFNTQKIPEKKSNKNDNKNVENSQLRNIILEYIPSNNNETKNNQNGFIHISIDDQENQNQNQKENSIFNLLPCSIKISQLERIDKMDLVLESETINAIFKVKNEELQKIKHLISTKPFQKEIETNEIRQTIDNLNKDIFKQKKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE97</accession>
    <name>A0A9Q0LE97_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE97"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040493213" evidence="1">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="132" mass="15233" checksum="39CF8DB6DEC67DD0" modified="2023-09-13" version="1">MKAELLVIFLLITIGFAKQDFNMYTYNGTDCAGQYQWRHQYQTQTQNQGEDGGQFKLEAGTNKQWAWQYCYSSDNCTTVLELDFNECHNITEIEAPTLDVLTAWDGESFELTDSAFQLTFAILSLFALLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEZ5</accession>
    <name>A0A9Q0LEZ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein yeez</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEZ5"/>
    <dbReference type="OMA" id="HTAFDHD"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="301" mass="33109" checksum="B23F96BBFA2B5BD7" modified="2023-09-13" version="1">MKVFLTGGTGYIGGAVLEKLIANKHEVTVLSRTEEKAQKAKELGAKIILGDITETEKLKELATGYDAIIHTAFAFLQEGADKVNLQVMQALIDAGKKNEKPCIAVFTSSLWALGNTEGEEIADEDTTSHDPVGLFLWRREHEKIALEQANDNFKVAILRPGWVYGKKGGFVSFYWNVCEKEKTVYYLGDGNGLFCTIHVDDIADLFVTIIEKKATGIFHGIDGKPNKVIDIANISADILGISKENIKSLPLQDAANKFGPLAFGMSVFQRAIAKRSLELGWKPTRPSFPESAKSAYDELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFI6</accession>
    <name>A0A9Q0LFI6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dedicator of cytokinesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_09801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="FCADTYG"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="9">
        <location>
            <begin position="485"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="10">
        <location>
            <begin position="1378"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5071902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1802" mass="213093" checksum="12208F935FEA1170" modified="2023-09-13" version="1">MTSWKQTRIFGVAKYKFSAKQESYLKTDFGDPLFIKEETEEWFRAKSILTGKHGIIPKTYVEIIDEPIPTKQNFLARETHPYIHANPFLILCKRFIVTYRKIMDFFCFEKRDFAKQDEIKFYVGMLIQLQKEVLNRSGNKDDVLQAQEQILNMIQNCQKKLRLPAVPRKENGQIINPKAFGMIESFEYFKSLEDPRQQLSLEKEKKGAKNIQLLFEFNAAILLLPSEAEVRFFLYSQSEKRPITEIYSLNIEKTGMNKDIDKHGKLKTVFKDLTASDFSGQLYIVCQILRVGPVSLDEKYQKKGEKKESEYKRPFAVGVLELLQNFLKTTKETKKEETITMYSLTNEANFPKMHEIILNSEQTLKKLDHGVTISWTVFQGDYDDIIKEKEEELQQKMEDIKKKQEKQEKTGETETETETDTEHTISIDRQETKKSTNLKSNLISMEAEEQKKRIEEQLENIREFKNTGFTLKTKFPDVILPSYIRNDLYITLLEGEFNEERKASSHNIEMRVYVKMNDCKDAKNFVTDCISYGENSNRLSVYKSSVYYHKNNPKWLETFRINMPVDQFEKSHLYMEFVHCPVKEGQEDKVISFAFLPFFKNGTMIQQGLASFHTYKYVPKVLKDEPVFYLTEPESQQKQKTKLVPRKEQIKINIDLCSTRLTQDTNVTGLLKWKESTQPLNQILKNFTYAPQNEIVKFIREILDILFVLLEQKGSGKDTKKSIYESIEYVIGIVSDKRFKNFTPVLNDYLQTRFSDKIINTQENDNQQNILNQNLKKSLCTVYIFFIEMLKSKLSDTENAERKSLLSSMKAIEYSFKFIISSWILNITENPNEASKKSKVKSDLKEILALINTFMKRTTPVWINAAQEMALRHFKSIFSELSRIFKLKELAEFTKELIESVRKEDLKGLNQSKLDLIVYLFQERVFENRRSRVMIIPIILKQISFHYKMSEEEFNLCIEILLVILKRTFEQQKLYESKDTSKQQEIQQESFIFYEENNQNKEKPVHKERQPIRELLDFPRHLFQMLNYNDECEEKEIQDALLKHDGDHTRTSKEPSLSRENKPSELKRATSTSLLRIENDIPSEIESSPEILSIKFKRGEIRRKIVTGILSLFQMVDSSHVKTLLRVYDSHQQLRAEFLELIFTTFIKLINSPIYHKKLESLSIFQYFIILKTLKLFMNELHEKYIGSSYIKMWDSYFKALVEFIKSPTLQLESLKDFQSYQIKAEFGDMRLKAAKILEKSWRILDQKYSFITTKVPDFLSLITLDHDKLKELGLNIYYSMLVEEIKRTESFTVVEQSTVDSIDMFIEKKVESKFNSYFFSHIQPKFKENPTYEAKCLNFVEQLQQLMDHLSILNDYPEEERYEDERTFVLLNLMDYLQKTKRYSMYAKYTHYLARLHLRNRNYTEAALCLSKVNDILEFNEKKVEEKMSELYFEYPRETTAERKERIIRNAATFFDKGKFWEKGVEFLNILKERFEKFTFEYDKLSEILKKQSEMYMKIFETERFFSSYFRVGYYGKGFDTEIYRKFKDKEFVYRGAELEQLSVFMEKMKAKFPEAKIGSTDPDDEIKEGNGQYIQISNLNPTSTEEMEGWKRSFSDRMSERIRKYYTHYNVNTFMYSKPFRKSKEKSSNEFKDLWLRNTFFITEDAFPGIKRRTTVIEKQIIEVSPIENAINSVNEKNDELISKIHKYESFNGKNISPFSMAFNGVIDAAVNGGVFKYQEAFFNDEFVKESFQNEQCVGDLKYALKKQQSVLEAGVLLHSTICPEEMKPFHENMEKQFAKMKQILAPSLKGVQLIEKFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFJ8</accession>
    <name>A0A9Q0LFJ8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFJ8"/>
    <dbReference type="OMA" id="DDAYNWI"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="5" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="183"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="474" mass="53702" checksum="915380D0F34EF1E5" modified="2023-09-13" version="1">MKSNKNIGILAIEVYVPQLYVSQEKLEEFDSAGKGKYTIGLMQSKMSFCSEIEDINSISLTAVNQLMKKNGINYKDIGRLEVGTETVIDKSKSVKTTLMQLFDESGNHDIEGIDCINACYGGTAAFFNSVAWCESSAWDGRLALVVAADIAVYEKGPARPTGGAGAVAILIGPNAPIVLENSSGLRGSYFQNAYDFFKPNLDSEYPVVDGLLSIKCYFNALDNCYSKFRKNVENFSLSKIKDDPKEKDNANNPLQNTRKFTSDSIDYCVFHSPYNKLVLKSWARIHYLDFCYFPENLISEKNLDLQFLKKFLDLKLEDTYFNREIEDNFKKISHESYNKKVDPSTLISNNCGNLYCGSLYGGLASLIFNTNSKDLIGKRIVMFSYGSGLASSMFSLLVREDPTEIKKNLDIQNLLDQRIEILPNQFTDILEQRKNNYNKKDIKPKPLEIETLKSNVFYLKEIDSMGRRFYFQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG35</accession>
    <name>A0A9Q0LG35_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_10462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG35"/>
    <dbReference type="OMA" id="MPEWIVH"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000020">
        <property type="entry name" value="Pre-mRNA cleavage factor Im subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="282" mass="33298" checksum="AF82E986B22F7EFC" modified="2023-09-13" version="1">MSIATFVNLYNLSCYTFGKKDSPPEKDNSLENRINRMKEDYEKNGMRRSVGGVLVVHEHNHPHALLLQDKEGLFTLPGGKLKPGEGEVEGLNRKLTQKLNPKNTQIFYHNWEIGELLCIWWRPGFNMNFYPYLPVHVTKPKECRKVYLVRMPKAAKFAIPENYTVRAVPFYDLFDKTNDFEQLVGSIPFILGRFHFKCHKKETEEENQNQNKNQNQNKNQNQNQNQNQNENENENENENENENEDENENENENEDENEDENENEEINQNNQNSKMEEETKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG45</accession>
    <name>A0A9Q0LG45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG45"/>
    <dbReference type="OMA" id="YHLHYYY"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="130" mass="17546" checksum="9A9C8E298E7B8E2F" modified="2023-09-13" version="1">MKSNLTFLNNVKFLFLYFLYSLYSLYYLYYLYYLYYLYYLYYLYSLYSLYYLYFLYSLYFLYSLYYLYYLYYLYSLYYLYYLYYLYSLYFLYYLYYLYSLYFLYYLYSLYYLYFLYSLYSLYYLYYLYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHM5</accession>
    <name>A0A9Q0LHM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab a59 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHM5"/>
    <dbReference type="OMA" id="MERYCEG"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="67" mass="7532" checksum="B3C9EFC79B9981EA" modified="2023-09-13" version="1">MTQDEKTLKILLIGNSLVGKSSLLLRFCDNRFNEDMGTTIGVDFRFANISVEGESIQLQIVNGKKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHP1</accession>
    <name>A0A9Q0LHP1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHP1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="150" mass="16892" checksum="349F541CDDD11F6F" modified="2023-09-13" version="1">MGLILTQKQISMKQPCILLVKNILSSYFWTALHLLCGNSYLSSKKNIAYLVEKGIDIHARTIDKGLDVNEATNQHQTHLYIFALLVSNALLDVVEYLIEKGADINVRAIQNETLLHVACQNNSFEIIKLLVQNGIDINARNTILMKQLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHQ9</accession>
    <name>A0A9Q0LHQ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spectrin beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHQ9"/>
    <dbReference type="OMA" id="QMMENIN"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000023">
        <property type="entry name" value="EH domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="131"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="634" mass="74896" checksum="6DE08CCEFE876242" modified="2023-09-13" version="1">MIKKTILDEISTDSFKTQKQVCLRWVNKYLKKTGESITDLEELEDGLKFIKLVEDITCEPIQKYNKNPQTRNQKIDNLKIAIEKIEKIKKIKFINVGAEDIVDKNIQITTEIILSIIFQFSIEEIIEEDFTPKQDILLLWCGKQTQGYANVDVHDFTTSWKDGLAFAAIIHRYSPSSIDFDSLDPKNIKENLEIAFQAAKKIGIEQLLESDDLMIKNPDPKSIMIYLTEIFHHFNVEAKQEKAKKKIPYFIQFIKTTSKLKIKYEQLAQNILNWIANKTQELKSKGFGNSKEEALKSFLEFVRYKKEEKQNILNEMKTLQILYRLIERRLKCNKQPKFIPKGKSVQKVKEKWNILLFEENHREGLFYSKMQLFPKEIHIDSKQQEYLETKRMDFMRKADAFNQYLQKTKKLLSEISGEFEEKLDEIKAINSSLNENKKQINDLIYLEVYLRNQNIVNNPYNSFIAQELNQVYEQLLNYSSKQKEILTNAILESKIRNFDERKIKGRRDLYDYYSGSKGVLDKFSFAKCLKSLDGGSMLNIMKSFIDRLDQSYSGVFEFENFAQLVDSFSFQTESKYQILRLFWFLSQNKLKGLITDNEINLFFSKKDADFLRNHLPKEENDYNYIKWIQSLFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI54</accession>
    <name>A0A9Q0LI54_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dd-gdca protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI54"/>
    <dbReference type="OMA" id="INKYSCT"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052326">
        <property type="entry name" value="Diff-Dev_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33459">
        <property type="entry name" value="DD-GDCA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33459:SF7">
        <property type="entry name" value="DD-GDCA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040270202" evidence="1">
        <location>
            <begin position="25"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="635" mass="70357" checksum="606F746BBA962B7A" modified="2023-09-13" version="1">MKNISTFVLFVFVVFFEIVFLINAKDTEPNCNPKVWRKLNEACDETQECYPFLGCYGGICQEPNYGEACYNDSDCSTGFCEQYSMTCLNQVEYVDDQCVTDEQCTSGSCSQITMTCTGIGALKPCNTSEPGSCTMGYYCSNTTGVCEVSANLGENCWNQTNNSKPEERDFICMDFGVCNLNSSSDPESMFCVEPMSKQIGEVCSDPEACVAGSTCNNNICTANENSVCGDDSDCGWGSYCDCGSSTENRDTITGKCQPLFNMNCTTEVAEVLACVEEVHCHHESIFDQGGCAYKACQHQIDILECCLAHGFPNEFYPENRDVCEWCEAIPPAEIYHACDESAGIYCATNLFCFNNMCIRSNYGAKCTDTTGCTSLNCADETGKCDSAFRYPNDPCTEDWQCYEASSCVNGRCRAPGYWESCDYWGFCDVGYYCDFTDEVCQNASFIGESCKDKYLQSIVHVDACSNFTICDLVRDECVLPNSLGFNETCGSTDSCEIGLACVNNTCQEQVGCFDNKDCANGYICSCSVDTSYPGACIPYQNMSCQQEFMDFVSCASSYNCFMGDFFTQGNCPFDMCREQATKYQCCSADGYELEYFLAAQVYCNAPSPSFSVRSSQFNVFVVLICLEFLLFHFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIC8</accession>
    <name>A0A9Q0LIC8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5071993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIC8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="73" mass="8720" checksum="253C0697A78C1793" modified="2023-09-13" version="1">MNSSLFSINQLRNTNTDNFLNFPIDFSFEKKSHFQNVFLHQKKKYQKLLCERTKGNETLKKNCLKKKNLILNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIW9</accession>
    <name>A0A9Q0LIW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIW9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="749" mass="87251" checksum="F55CEDE3851FED24" modified="2023-09-13" version="1">MVNEIIGNQNISTLVIRLIYQGFSSKLFIPSFTFVNKIVFLLEKINRYFFLNFIFTNKKIYFSFFSFSMNSYFTQLFFSENEILSKIHQNKIQNKETEAIQLENNFSKLENKFNFFSEGYKSLRQQILDYMEEFEKLNQNLHGIDGSIILKRLIKKLNFFIDSFITAIPKLFPLDEKNSIYANCQPKNSFVIKQSQLGDNLESLSNFSAQNHESKTDTINQKILELIQNLSNFLKEGRKNSTFFHIEQNDSFKKLQERQNPLKEKILNFRDRASHLILQFQEFTDDKPDEEVTLEINQLRQLATMRISTFRSESVLDNLQQKMEKFKTFPQVDTLIEKLDSLSTSLQKILQSIEFSSKNVFNTVSKGNSSISFEFALFTQCFDFLNSSITNFDSHSSIKNDFLIQLLLGFLKFLDLILDLLLEISSISFNTSFHQNQAQSKTNQIHSKDIEEKNSKKEKTSENDPNQTVDFFLNQISQLSLNFNETKQSEQKNCFVKIGVLNAGRLESNKINQILSHLVKNYEIDILMIQNLDSNSVVQIRNFDTFGNSELSHQQINIKEIDLNPQSRKKDLSFFISSSLMNHFKLIDLSEYIQRGYFPRQIKNDQFRYHFGVIEIGDLIVINFLSTCYSQTKLLINFCAVLEKLFPQKQIVIGGSFHSSIKNISSLFSTKSPKSHFRPIPNLIKKSHFIDSFPFFQYFLTNYSNHLSFSRSPFVFGDEADFSNLHVSSLKILNSSLLLNVFQFGIHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIZ2</accession>
    <name>A0A9Q0LIZ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIZ2"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="109" mass="12262" checksum="9300D6F860DCA697" modified="2023-09-13" version="1">MIQLLVNNGADFHIQSASPFHNLCGNTSITADMIKILIQKGIDFNLQLPSPLFVLCQNPSITEEIINLIKTTKADFNLKIGDDWYIEDKSYSRGTKPIDLLKDSLKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKL4</accession>
    <name>A0A9Q0LKL4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab-gap/tbc-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKL4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="228" mass="27282" checksum="1ADE898A87EE3917" modified="2023-09-13" version="1">MLQNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNNNNNNNNNNNNNNNNNNEQQKEKRTIFLFVNTTYVDEDETVQIIFKNENENENENENYIDIYQNFEMNQLKELNPSIWYFDNFDKINQDSIFQFEIIPKNQNQNEIENEIENENQNQNQNQNEIENEIENQNEIENQNQNENENQNENKNQNEIENEIENENENQNQKKNSKSKSKSKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKX0</accession>
    <name>A0A9Q0LKX0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Poly [adp-ribose] polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKX0"/>
    <dbReference type="OMA" id="SKHEPKH"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="678"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="530"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="958" mass="112016" checksum="699B1C812C307D27" modified="2023-09-13" version="1">MFFDNSKHSKHSNPKQESNSKHKSKHKSKHKSKHESKHESNSNSKHKSKSNLKHEPKLKHESNSNSKHEPNSNLKHESNSNLKHESKSKHKSKHESNLKHKSNSKHESKHESNSNLNSNSKQESKHKPKHESNSNSKQESKHESKHESKHKPKHESNSNSKHESNLKHESNSNSKQESKHKSKHKSNSNLKHESKHSNTYPNLNQISNQESKQESKSNLNSNSKQESKHEPKHESKHESKHKSKSNLKHEPKHEPKHEPKHESKLNHESKHSNTYPNLNQISKQESKHNSKHEPKHESNSKLKHESKHEPKSNQESKDNSKLKHKSKSKHKSKQESNSKLNQISNQESKHEPKHKPKSKHSNLKHKPKPKSKSKSKHEPKSKSKSKSKLKKEINTNQKPSDLGKNEESSESDPSLDFFGEKVVKPEKIKIKVAFPWFNKQSELRQKIKEFETQNSSKNNQEIYNNDLEIGMDSIFQDLELMRRRNRDKNKNKNKNKNKKKNSKKNKNKNKNKNKNKNKKKKKKKGKLKSYSDSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSDSNSNSDSNSDSYSYSYSNSDSNSYSYSYSDSDSDSNSYSYSDSNSYSYSDSDSDSYSDYLKKSQLYQKIQAIQSENRIIENEIIKTYKPINQQNQQKIPNVSEYPPIISENFCRKYNLCEKFFLQGYCDYPNCKFTHPKELIRCRYIDRPEGCTNKNCQYNHPNPFNTLHMKNFDYRIQVNREKTLFKIPFREMEKEECKYWKEKGICTNFNCKYQHKGAGFHQENKFENYQSIKREYQFRNPNETEEFMIKNIWKLQSEKKQNEPQAKISRIQIIENKFLHHRHSYMMIKAKESGIFEGTLWGFHGTSSRSIDPICRDGFSRDRQTNNAFGKGTYFARNPNVSVGYCDNTNQMFLCELCVVKDGIIYQAVNQYYIIPNVENLKPYAVITFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLY7</accession>
    <name>A0A9Q0LLY7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLY7"/>
    <dbReference type="OMA" id="MNACSER"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="150" mass="17466" checksum="278012AA15D2F69A" modified="2023-09-13" version="1">MTQQVLTEEQIKEFKETFRLFDKDGDGEITALELKSMLQSLGQNPTDQDIQNMIKEVDVDGDGKIQENEFLKIFERRLNAEEDENFVQMVFKLLDKDDDGYITSAELNHFLNSIGERMTSEELEILINFADTTKQGRVSFEDFKRVVLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM08</accession>
    <name>A0A9Q0LM08_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM08"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="26"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="475" mass="55652" checksum="88E85A1E3D7ADFC6" modified="2023-09-13" version="1">MKFFSAFNPIRNFKSIFSRPSRNHIQAFDGIRALASYWIFAYHTIVFLLWLSEHGILSRVLPNPILKIILMGDSSVDIFFILSGFLVYSRFLSELKGNTIQNLDLRIRLRYLTNFLIRRFLRLYPLIYFFILLKILELVALNDLKAGIPQILLTMFFLNDVIAGNEYTPVGHSWSVATEMKTYFILLYIKNQMMKTGKDSTKLLIKIFVIALIVYTTGVIFAPKFHKYPLYTEIWTEELCTLFHFQPETGNFILEHPETLAEDNFRRFLLYFGFHSRLPLIIIGCFAAFIQYRTSFPEKCQKSKPFRLMILLIGLILFSSLFILKTTHYMSNIQIENITIIQQIIIRLFSFNRIINSIGASLLILLIINKAGIFGNFFNYFLSLKIWIPFSNLSYSLYLTQVVPIFLLEMDLIKKFGFDWIDTRNSFLLILKATLVVYPISIITFLLIEKPMINLSPERFKLEQFISGKEKKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM40</accession>
    <name>A0A9Q0LM40_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM40"/>
    <dbReference type="OMA" id="DRQWGDG"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="82"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="275" mass="32407" checksum="09CF3A2522171A38" modified="2023-09-13" version="1">MKENQVEIQPFSKKTVQIFNNIEYQVTKVIPFYSHTKKEPYEEEDEKLGISNPGRRVFSNLFPSKLNIKSKFFPSIYEEEQKEQIVFHDFLLENEVPSVENFFQSTKSLLEADARFIALHLNPSKAAGYGQGRYSLSTKEKNQLIQLGVNPSDFVVSKKKRVIRSKTGYPPRIENWDHKKIYVMLAGLRLKFKEPNSEFRYIMDTLIQTKENFLFIEHTKNDKQWADGLYGNGTNFLGKLLTQIFLEIRNETEYKVDKEFLLKPNKEFVEYKTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMG1</accession>
    <name>A0A9Q0LMG1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bypass of stop codon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMG1"/>
    <dbReference type="OMA" id="CAMESYH"/>
    <dbReference type="OrthoDB" id="409243at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="471" mass="53497" checksum="B65A1D6E7918400F" modified="2023-09-13" version="1">MAEIDKANEIKEIKETKEIKEIEEKEENDDLEDNEKIPININIRDIKESIKIKENAEIEEIEENEKEINENSDEEKKSLLSIDSTDPNQLNPDVCSEKEKISDANRAFREIFITTFAQFMGYAALFALQAELKKKYDINEGTTKSHIFGFAVSFLYIGNLLFRLGHNVVFALFKPRDRVLISITSMSCSMIILFFTISANSIPSMAWVFIAYILGGIGIGTFEANMLRVATPFGPKTKAWCLYGIPPGIVMITIGSFLLMQVGVHVKWIYLSVLCFLVFGLILYLIRIYRRASRIETISAKEFIKFFRKFPRKIWEPKVRPYALTMMVNMFSVSLFSPGVILYIFGKNDIFFSGTSTKMAYHLFVTIYDAGFFIGDLGGRKLIYRSKKNYHPAFFLILNIIGIGFGVSHLSELAITAGIFIALGNGIIYSLSCRNIDEKIDRKYNLIGLSYWLFVGDIGSVIGSNLISFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN20</accession>
    <name>A0A9Q0LN20_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN20"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="554" mass="66158" checksum="29F628CB93866EB8" modified="2023-09-13" version="1">MNNNNNNNNNNNNNQNENQIENQIENANQIENQIENENENQIKNLQKKITKNLIEDYSNLLNGNSFKNFSIFVENKSNSFEFKVHKSILSTRSPFFNEFLKEENEINQISLEEFNKKEMESILKYIYHGNISFENQENLFQLFQISIYFKLDLLKKILQKKISNSINYSNFFQFFFQNRNLKLNEIEMKCFELINQNFSKIKNNENLFNLTEEEIIKFIQFKQEKKENFQFDFFQFLMEWTQKRNERLKRKKEKERENEKKRLFHSFFSLFDKDSISKEDFDKLKQFDSFPNSFVIDIQNQVIQNKDKEIENKDKEIENKEKEIENKDKEIEAKNKEIEEKWKKEVEELKYKFELIELEKIFSDSEIIKDNEYVKKLQEWINDDDFFSKMKKGFSAKRDGFDCKKWHNICGDKGKTLVIIKTKDNFIFGGFTEVGFSSNPSKWSENNVSWGKITDANAFIFSLRNDKGDRKPEKLKVKKGQEKEALRNSYENYGPIFGAGCDLQLSSNLQPGYTNFGDSYTLPNGVIYQTALSKSYLAGSYDKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNA0</accession>
    <name>A0A9Q0LNA0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="INCKTNR"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="661"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="694"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="727"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="760"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="794"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="827"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="860"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="893"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="926"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="959"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1125"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1158"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1224"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="1528"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1470"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1631" mass="186341" checksum="8BED7062632E2A0A" modified="2023-09-13" version="1">MNISNYLANTNLNENLNSNSNENTNLNLNENTNLNTNTNLNSNENSNSNTNTNTNLYLNSNENNLNLNENTNLNTNTNSNLNTNTNENINGNNTNENLNTNINTNENLNTNLNENLNSNSNTNINTNSNENTNTNLNKNLNLNTNLNTNSNLNTNLNTNTNENTNLNSNENTNLNTNTNTNLYLNSNENNLNSNLNSNLNTNLNSNENSNSNTNTNTNLNTNLNTNLNLNENNFLISKIIKQNNLNLLNQIKTISEKDFEKQNKPILNFAIEKKVSKEMIEKLIEKGAKINSVDKLRRNCLHIAIIKNFQIEFVKFLISKGVNFNSKAKQNKTALHFACQKNSSFEVIKYLISKGIDINAKTTQNQSILHFACQKKPIEMIQYLVSKGVDLNAKTNQNETVLHYACQSNSLQVIKYLISKGVDLNAKTNQNKTVLHYACQNNSLDVIEYLISKGIDLNANTDENKTVLHFACQDNSLDVIEYLVSQGIDIDSKTKNNRTPLHFACQKNNIKVIKYLVSKGADLNSKTSQNETILHFACQNNSLEIIEYLISKGIDINARTNENETALHFVSQKNSCKIIEYLLSKGIDINSKTKTSRTPFHFACQKNSIQVIKYLISKGIDINAKTIKNETGLHLACQKNSLKTIKFLISQGLDINAKTNQNETVLHFACQSNSIQVIKYLISQRIDINSKTKFNETILHFACQKNSIQVIKYLVSKGIDINSKTNQNKTPLHVACQKNSVDVIKYLISKEANINCKTNQNETSLHFACQNNSVEVIQYLISKGVDINAKTKFWNKTALHVACQKNSLEVIQYLISQKLDINAKTNRNETILHFACQNNSVEVIEYLISKGLYINEKTNFNQTVLHFASEKNSVDVIKYLFSKEIDINAKTYWNETTLHIACKHNTVEVIDYLISKGLDINQKTSQNETLLHYACQSNTVEVIDYLISKGLDINCKTNRNETVLHFASKNNSIQVIDYLISKGLDINCKTNRNQTILHLACQNNSIEFIKYLISKGVDINAKTIENQTALHFACRFNSLEIIKYLISQGIDINAKTNKNETALHFVCLFNNSVEVIKYLISQGIDMNAKTNKNETVLHIASQKNSLEVIQYLISQKIDINAKTNENETALHFACQNNSFEVIKYLISQGIDINAKTNQNETALHIACQKNSIKVIKYLIEKGIDLNAKTNENQTALHFACQKNSIKVIRYLIEKGIDINCKTDEDQTALHIACKNNSLQVIKYLISQGININAKTNENETALHIACQCNSFEVIKYLISKGIDINAKTYWNETALHFACENQNNSIKVIKYLISKGVDINAKTSKNETPLSISIQNQNQKATQLLLMNDVNIFDLEEEDEEMMKEFIEIFTQIYSINEDMNNFLKLNLNGVFSDFQIISKDSFVFNVNKLILLRRFDNDRIIFQKFINICKLKPKKEVEIILNFLYTGFPDFQELQNKLNLNLNEIQFPNEKKQEEQKQEQNELNEKENKITEFLKEIGIELNWIKQKKGRKGILKDLTKLYEEEITKDFTIIVSEKEIKVHKLILIIRSELFKGMFELNVQDSSNQVHDYSRKSFETIQQLIYFFYHDDLEEDKINEEIIIQELEDVKDYYQLNPNSIIDLILFHQTKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNF6</accession>
    <name>A0A9Q0LNF6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_06673</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNF6"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5075811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="319" mass="36148" checksum="AFB4FD7058156119" modified="2023-09-13" version="1">MNNKNQNRNRNRKLSQNPRGKFQGNQRNQGNQRFQRNQGNQRNQRNSRNQGNQGNQRFIKRKKENLGFQGKKRKSGGFKGGSTVIIEPHRHDGVYIARGKEDSLATRNMNVGESVYGEKRISVQQTEQEKIEYRLWNPFRSKLAAAILGGVDNIWIKPGCKLLYLGAASGTTVSHCSDIVGPDGIVYAVEFSKRSGRDLITVANKRKNIIPIIEDARHPLKYRMICSMVDVIFADIAQPDQARIVIHNAEQYLKNGGHFIISIKANCIDSTISPEAVFAGEIDKLKEANLKPKEQVTLEPYERDHAVVIGTYRPIRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPV3</accession>
    <name>A0A9Q0LPV3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_00109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPV3"/>
    <dbReference type="OMA" id="CFFHGIR"/>
    <dbReference type="OrthoDB" id="28186at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040416">
        <property type="entry name" value="TMEM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="7">
        <location>
            <begin position="147"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5076792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="463" mass="54694" checksum="45788FA8B6467355" modified="2023-09-13" version="1">MKESFITTLSLGIGAAGPVVMQTQIKNVQFHPDNDIQMYGEINDLDRMNLELMIGIRFQNSQPIDIVTQVIFDLELYGRQSSSDSWSLVSSKSEHKRDIVCDRGVDCKKVYFVHEPFIEYSEYEFFLNVSGTQSLFDLAIFDYEFYNKNFTTFRLVFGYVFIMFSLSALFLWAHQTNGIYWKELSQEQKWQTILLFGIFFFNNPFFPTTALVKSSIPNFFELFFRGSFIILLFLFWLSVFDSFRFSRKEISFRWFYLPKIILLSLIFIIFFIMEIISISHLKTDPQYDEGKDLPAFKTLTIISDILLIIYLLWIFYTVYRAFREIKMFPQKKNGFLTFFLLSTIVFIITVSYLIAEFFNANQVTSLWFLLLFGPFNTYVYFLVYSFIPVKIEGIEKLENIDNESLSTSDNNQNENENDNENDNENENDNEIKLENENDNEIELDNINENDNLNENDNENENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQK6</accession>
    <name>A0A9Q0LQK6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">magnesium chelatase</fullName>
            <ecNumber evidence="1">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQK6"/>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="3">
        <location>
            <begin position="426"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="485" mass="56789" checksum="733D3206A839024E" modified="2023-09-13" version="1">MNLQSFDSTFSSRKNTFQKRTTTNLFNEIPQIIQEQNVLTLRTLLQKIYEKMMINIPPNLLLSLLVCLLTQSHLLIINSTFNDSKLQKKSSRQKEMEKKIRNVEHQNQIFSHIIQQIVPLIFGQNCSVLTCSQKTSLSDLYGDYYKHNILQKNQKSKVGNQFFLENYEQTQREKQKQKEIELEEKLPNKNSELEKSLVQTEVIQENDIFVEEDLFSLENDPNFNLNLNENNLNKFGKANHNVNFNENEMTNFGFESHDKINESRQFFPLISNFDAIKSHISGFVGKNQPLFSNVLVVENIHLAKEEIQNELIKAMKSNLELAKDFKKFLPSPFVLISIINEKSDLPWIFRDYFHFCVELHSKLYVDIKKTFISPPLFSSDEYLSFRELTENVFCHSDILQYSRDISQEFRNFLFDSPSLFKIADCLIRFVKPFALLHGFNFVIPDHLKMIVPFVVSHRIQLKSNNLKGNINEIITKILEQVSVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQQ8</accession>
    <name>A0A9Q0LQQ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQQ8"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="215"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="391" mass="46041" checksum="F779861E3F1492A1" modified="2023-09-13" version="1">MKEYQENKMILKDVSSPILSLILNYFYSGKIEINLENAIQILIFSSKYLIDELIEICSNFIQKNFQIEFVVDVLKLSESMNFNQLLDFCYQFIFQNFEEFIKTSFFLELEENHLNSILSNDNISANEFDIFQSIIKWGKHKSNINQVPNVIDKIRFIDFTKEQIENVLKEDLIPNEISQKLIQFQNIQDEKELNQFIEQEKSFLFKSRMRFKSTTIQGIKDVNKLREWINDDEFFYKMKLGFSSKRDGFSSKIFHQKVDDKGKTLVIVKTKDNFIFGGFTQIGFTTGINNRIIPDEDCFIFSLRNDKNDRKSEKFPIQETKVQNALRYNFDYGPIFGGDIWLKENLQTGYTNFGHTYNLPNGIIYGSNEAKSYLAGSYSSWVVDELECFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQX8</accession>
    <name>A0A9Q0LQX8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Straightjacket isoform c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQX8"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="96"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="209" mass="23866" checksum="FD2BA39B5B21F7C2" modified="2023-09-13" version="1">MTESEIMMGAQDIGNFRAQIEQTKTIDTNSITYKGIFSEYFFYYGKQEEKELLTTDTSTAITINPLTKEKEYFLSFGLKSKYDGEGIKKYGRPPLNLMIILDISGSMSDSFRIDNDLNENEAIANKLEIAKRAIIGLLPHLNDSDNFGMVIFDSVAEIFENFGNWKEKNKEDILERMKSLKPRGGTNMEKGLSKGAKMIQKFYSTKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR25</accession>
    <name>A0A9Q0LR25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Organic cation/carnitine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_06800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR25"/>
    <dbReference type="OMA" id="TWRNYTL"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5075938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="598" mass="69118" checksum="B8F51B5DF45EA105" modified="2023-09-13" version="1">MKKSKIIQNQNQNQNQNQNQNQNQNQKEKLIEMTLQEAINLLGFGKFQIMMMFALGICWSSDAMLTILLSLLAPVIKKEWNLHSYDQTILVSIVFTGMAIGASIWGHLSDIYGRKIGYLITAIFCFIFEILSAFTQKFWQLVLCQLMVGLGVSAIPISFGMFSEILPTKRRGFHLVVFVFFWSFGCLLEAGLGWILITKFNWRVFLFCSAIPMSFLLVLWKWVPESPRYYYITNKTQKLNDTIKMIARVNKISFPDNFRIIKTNSIQNQETSSLLSYDSNQNNKNEEDTLIKKSGIIVYNDLESQEEFSFEQNDSENEIQIEIKKESKENSNIEKENNKEKEEEEEEKLNLKQNEKNQQKYKLIKKKQTLWKGLKEMFSKKYRRTTIILWIMWFVDTFVYYGLVFITPSFIHQYSFGNVYQSTFITTISELPGIFIASLIIEKIGRKITQTAFFISAGISIALLMIGSNPIFHIVFAMISRASMIAVFDTTYAYTPEIYPTEIRTTGLGFCSALSRFAGIISPIFSFILLDYNVYIPLATFSFLAIVAGVSSYFLPFETSGVSMTDSNFESFEKENIGNFKNDLKKKKERKDFVNKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR97</accession>
    <name>A0A9Q0LR97_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">M0811_00571</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR97"/>
    <dbReference type="OMA" id="WSYFIVL"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF216">
        <property type="entry name" value="P-TYPE PHOSPHOLIPID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="867"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="979"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1013"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1052"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="831"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="805"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="808"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAJ5077251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1180" mass="135024" checksum="1371E2A6057F6059" modified="2023-09-13" version="1">MKKQKKKEQKKQKQNEQKKQRKIIITDQERGKDFPFVGNSIKTTKYNILTFLPKNLFEQFRRLANFYFLIVIILEYFPFSPLNPTVSVLPLIFVLTITAIREAYEDIQRNKSDSKINNSPTICLRNGSFQTMKWKDLKVGDIVKITNGKFFPADIVILSTSEPMNMCYIETCNLDGETNLKIRQGLQVTSFLNNNENELSNFQATIDSELPNNRLYKFNGALNFNEETHSLSNTQMLLRGCALKNTKWIIGVVIFTGSDSKIMKNSTDPPSKRSTIEKQLNIRLISIFIFLGIIGLVGAFFSGYWQHKWGGSKSWYMGDEVNHDNLSPVLIGVYGFFSFIIVCNVMIPISLYVTMEMVKLIQTIFINHDIDMYHDETDTPAKARTSNLSEELGIIEYIFSDKTGTLTCNIMEFMKCTIGGIKYGNGVTEVAIAAAKREGRILENNRKKNEPAFNDDNLLNNLHQKTQSSQMIHEFLTMLSVCHTVIPEKNQENESEIIYQASSPDEGAFVQAARLLGYRFHKRTPNSITVEIEGKDETFEILNVLEFNSTRKRMSIIVRTEDGTIKLYTKGSDSMIMERLSQESQDVDVTNNHLEEFAKDGLRTLCFAMRVIPEDEYQKWNKNFHKANIAIENRQEKLDESAEEIENNLQLIGASAIEDKLQEGVPDAIEELSKAGIKIWVLTGDKRETAINIGFACSLLTQNMTIITISGNDLQSTKNALESAIKENSNLDDNDDIMKKNRNLGLVIDGATLEYALNGDAKFSLLQLAQMCSAVICCRVSPLQKALIVKLVKDNLDVISLAIGDGANDVSMIQSAHIGIGISGQEGMQAVLSSDYSIAQFRFLKKLILVHGRYSYRRITKLIVYSFYKNMAFSIMQVYFAIFAAWSAQTLFDSFLISIFNVVFSSLPIVVISVLDQDVSQDAELRYPQLYSDRSRNFLFSFTRFWVWLFQGIYQGAIMFFIPYFIWKFEPLSSNGQVLGMWGMSTTIYTSLIITINLKIALETTFWTWMHHLTIWGSIVVWFLFAVIYNANLKISSKMFHVVFQTLKLPNIWLQILFVVVLSLFPDFVYKYLSRYYRPHYWQIIQEQEKIKPKKSINTVNSFNMQEPFLVDSAEELDKLLITEKMNLNEMNYIVDGKSEKFTGFAFSTPHNSSFGIVDKNLTLTFYDEDGENQISEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR98</accession>
    <name>A0A9Q0LR98_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein rab-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR98"/>
    <dbReference type="OMA" id="RFRAGPY"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001204">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="200" mass="21962" checksum="087DB6F47F677C6F" modified="2023-09-13" version="1">MTTKADIKVVLLGAPYTGKSCLVEKFLNDKFTEGQKPTVAAAFGSKAVKVGSSVVTLGIWDTAGSERYESLSKMYYRGAGAAIVCYDITNHETFAKVRFWVSQLKENEKDCVIYLVGTKIDLILNDSDRDVPMEEVESFSDEIKAKIFETSAKTGKNVHELFETVAADYLERKKTIKNPSNNGGGGIVDPNKPKNKGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRD5</accession>
    <name>A0A9Q0LRD5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S-cell enriched with leucine-rich repeat-containing protein slra-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRD5"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="9">
        <location>
            <begin position="689"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="756"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="756"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1095"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1114"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1131"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5076530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1147" mass="131607" checksum="0D308D27E004990D" modified="2023-09-13" version="1">MGNTPKKFDVERLTFVNQNLKKIPEDLSKYPHLKILILQGNQITTLPIALTKKKTLTLINLSSNELTSLPQNLTKIQSLKFLILNFNNFEKFPPDLVKLTNLQTLEMFKNKIESLPDLDYKSLTALTSVTFFHNKISKISSSFGDLVSLESFDLESNNLHELPDSFANLKSLKRITLTDNKFVHFPLSICNLPNLETLIMNSNKIIEIPNGIHQLTKLQRLSLKWNGIQYIHDDFKGLSSLKTIHLQHNNIQNIPDSFQYLTSLSELGLSYNNLQEFPISIINLPELRTLYLTNCNINLTSEKNENENQIKKEIENENQIKTKKLVPLQLNLPKLVSLDLTENNITSFPENFFNNLPILSQIVLRFNKLEKLPSSFANLTTLASLSIEKNNLQEFPDCLVNLPNLFELDLTGNQISQLPSNFGEMKLFKLLLANNQLEILPKSFSNLSNLVVLNLSKNKFVNFPREILGCKSLEQLSISNCELNSLPFALICLRNLREFDASSNSIPQIPDSFGHFPKISFLNLSNNNIQKIPNNFAEMSYFPNLWNIKIDFSFNLIQEFPQNLSQIQKLKELDLSHNKISKISSEELKDLKDLRIFQCLKISHNNANNLDLSILSNHPTLEIVHLEGNTIEHEFQDKLTKFQIYSENGELLKARTFFPNLNELIFDYDTNLFPKCNGKAFNLKSKFHGVGYSEIWGRRPGMEDAIDIQCDIGKNLSIDFIGVYDGHGGRHCSNYASLLISKEISKIVDEIFPSQNENENQNQNENKNQNQNQNQNQNENENENQNENQNENQNENQNENQNENENENENQNENQNQNQNENENENQNHLENQNQLENQLENQLENQNQLENQLENQLENQIFNQDEKLKEKISQIFNKFNILFKNIREESGTTVVIALLTSKICHIINCGDSRAVLNKNGVGIRLTRDHKPTDVEERKRILEIGGSVTEDGRINGVLGVSRGLGDILFQPFFSSDPEITTFEITPETKHIILGCDGIWDVISDQEAVDIVNNNSHLDPNLIAVKLRNIALNRGSLDNISVVVVSLSSLISPQNSHSSLNNFVNLVSNEVFDDEFEKLATVTINELTEERNKQLTNQEDTNKNQNQNQNQNKNQNEKEKEKEKEKEKENENENENENENENQDQNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRL2</accession>
    <name>A0A9Q0LRL2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="LYHENIE"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="3">
        <location>
            <begin position="497"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2973"/>
            <end position="3033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1620"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2975"/>
            <end position="3017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3033" mass="361443" checksum="0C663244FA3C33C0" modified="2023-09-13" version="1">MRKILFAKINEINFATKFPLIIFCSGDANICENILLEMHSFENQSRNIIEINGKENIFETFDKNILQNFFAQNEYCNRIKVYVSEFSGSGKTFQIRKDIYEQNFNKNFKYHHKKEKEENIYIHIELPDFAYSQISDFLWTLLLWGSIETKRSIPENIFIWNFPSNVHFIFEIPSTRVEGTKSGLMFFSPLQFFRTIECEVNYEAISFYSYIPTNEGEIERKRNTDLFKVANLLNFFTLKFSELKGKKIEERKALFLKENENRKALFEISQELLGSHLKQKITFRILSNFWQLLKSQLDSLISHPLLNPEESINLFQNQQKAENFHYKFIKEYLLSFVRIIAPTFDSTQKIRMNEIEDLDNSSFQFQKILSWKKRVLYGLIAISKIKPNSHILDNSNNNLEGIHLLAENAKKLKLIFGKDICESLEKHGLIFSDLLPKNPSNEDYKELFKMLASFNTIDINIGNLSEMYAENEPKYRLTSENLLKMIFIQYKFYAHLPVILIGKVGSGKFSLITYLCKKIMRQKLQVMLFHERVKRKEIIHFVESAENKVNKKDKYCTIFFDRIHYASKKCLTVLKELFSDRMINGKLISNKINIIGAASISPQLVNLGNNISNINGNDEKTNEITKNESIAYQVHPFPYSFFDIIYDFSPKNNEEYHLYMQKMVKISLDKLSDSSSYIKNKKESILDLLTKFLFITGSFFSHNSKEFSLRDVAKIMRVFQWISKQKKQGLFVSTKNEDEKYLELFAISLFVCCGSKLERKLRSEYFAKIEKELVDSKRLNAENFKIDPIIERSEMKLIDLLEINYEEWSAVNSRSLRENMFLVFICCYTKIPLFLVNETNSSRKFAVEILLKNLKPHRKENFLEKYKLQPLEPIYMQCSSSTKASEITKIFEQARNNASYFNNNQVIYVVILDNVSFLQLSPDFPMQILEFELEKANKKLMNQAKSLIQNKEPFISILGLSDFQLDLSTLNGEIVFCYPKNTFDELKEIVFQILKSFYPQIPKKFAKKITQVYMLIRENIPNERKDANKYFGNADFYYLLKMIGFNTLNDPILYKNLQMIRNAIYRNCGLYPELVDRLHSQISSILELEYSKGIFSFTSLLRQNLSLSILDEEMFPSAKLDTKMLRYPNHFSRHLLILINHASNIPLVFSEINEKNFLFLNNSLFSEEKSAITVIQKLKKVQKAINEGKVIVLYRNEELYQPLDDVFSQNYIPESGNLFVRISFRNIAQTIRVNPKFRMIMLINDANFLETRTCEFLGKFEKYRLNPYYFVTSNEITKIVEKQFSTLQKIEEFTNYRIKREQLIVNYHPDLIKSYAKKYEKKPQKLQDAGKSWIVFCKFEKIVEMIDEIRNGNSEKLKKEFLANIVNEYQKLFYRNFYNFFEKLESKEKTKSKFRRFKKNWVILTYSAQNLAGLGLDKQYKVLDLDLSNFENAQKLKKYLASKWYNQIHDKKLLLCIHFTINKINASDIFQETKYLIEKMLIKHFLKYQKNYQIGQKEMNESFQRKYMIEKHGCYVFFFIHLASNEGSNDFWICYENNWNFYYLDELYPDYHFRFDKLKVKKPFLKEMNDFFDPKFLELKKNILPLALPSVDYGINPNFEQVLDQISELIEHENIESIIVTKIEWMVQQEEEKQEKQEEEEEEKFVKEIQNGKMSWEQIFRHFPGNISFLRFIYNLFLGKIGSVFVILSNSLHVNLNFMFNLPKEEDEHSMISQVLKKISSLFLEEFKFPYKNSLIQNVFQNLQFPFSFEIYSLIEARSSIYSRENKFLDTFTNKSFSQILEWINFKSEEREVNQNEIIHKIISRYFHDILVFSFGEKIGRMIFDIKTNFFDFLKRFTNKEIEDTTFKEMHIILSKKLKRDIFGIGKIEKNFRLLAQKNEKLMKLYVQTKSVNEFLFFSFIQNYIKAFYSILLNKNDMEMKKMASNLIVQSHENFQKLLLFFIKTMENRDQKENVIKILNSTYHWNQVLILRELFFCFVEVFEFELSKEKTNYFVSVLEDMTFKSEDVLKLFVPNVFQEYYIRLKYQVLPVIKFRPSFPLNLVNMGSMIFLSKFMKENLLENQQKISFDGEEENKEQKQQILQRNIKRKEDFCKKISIFSSWFFENVGAIMAEHIFIEYHLSKNNAVENIKHLVEMLIQNKEKQEMENLGIKNYEVAIFGFNFLVRKLIAILKRKPKIIGIIDIFNHFLGKSCFPKEKRIIQLIDEISPLELFQNDLNFEKIQKIVNFRSFCIEDPNQVIAQYADFLETEKGDHFLKFMCDSIYKTEGYSALIKFAKKNLMTFKQNQLLKEIVSQNHSLFFPSKMKMSEKEPEKQSLVEIFQQKVQGSQNQNTAKYESEISIFQKIYDSFEIFEKKIEKKEILCLLFHAIEVVWMINFEPLKTLLSEDILQDPKDPKAQEVIKQLGKIYWPGIPDLKFSFLFQEGLNKWMKCPTDHLCYLNNENEKKPDLVCFGCGKRMDKDLINELANNSKNENQKNIMYELAYEYSVWHEENGEYQEDQELLAKGLRNLSPISFVLIRIITNSVILCMSILSENFVNNFFVLLEIENQANQEHFIEFLQRKLVNDFNFLRQILDLSSYDDALRYLHSFLILMEKVQKRDGIEKVQERDEIEKEFEEMVNQKKFKIRQNIELQENNPSKKWETKTLFWPLIQYEKITYPKFIFSLEQYLMKKEGFPFINFVVEHWDMLSILHLFAGFWNFASYIFDQINTEISYKKAKETKISTLINQEKNQKKKDLLNQWYNDFELFWNIARRDVKKLLNYSGTKKKDPINIKKMDKNLEVAFCLFGMKNLFISIQDLITYSVSIHNNLIQKFTNEKGDSSVMIESKKLEGIRIEEDVLYFPFQDEDNNFVKVINIDSNEILFFIEDHEISEQFLPILENYLLGRLEKSLHFIKINWRINFRIFSRGFNDLSLSLEDHIWKQFILKQFSKDLKDAKGIENQFEFENEFEFENQFRNENEFEFENQFKNENQFKNENNNNDNNDNNENQNQNQNQNQFKNENDNNDNNDNNNNNDNNENENENENENQFGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRM5</accession>
    <name>A0A9Q0LRM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein archease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRM5"/>
    <dbReference type="OMA" id="HECYVIV"/>
    <dbReference type="OrthoDB" id="2190767at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="entry name" value="Archease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682:SF11">
        <property type="entry name" value="PROTEIN ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="MTH1598-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="114" mass="13627" checksum="34FD4F535B3CDE55" modified="2023-09-13" version="1">MGFALGMQNYIVEIDHVDIESEHEIEVTGHDKESLLYNFLDEWLFVFSTEFFILKKIEIIDFERNNNWKIKAKGFGEIFNMEKHRDYRGTEIKAITYSNMQIHEKEDSTNIFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRZ0</accession>
    <name>A0A9Q0LRZ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRZ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="134" mass="16411" checksum="59026A4D35BFEEC4" modified="2023-09-13" version="1">MKLMSMRKTKMKMIIKIQNQNQNQNQNEIEDDEEEDEEEDDDEDDEDEDDNQNQIQNQIQIQDQIEDEDEDEDEDEDEDEDEDDNQNQNDQFQDQIEDEDEDEDEDQNQNQNENKFQKKNQMKKRKNEDENDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSP6</accession>
    <name>A0A9Q0LSP6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSP6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1176" mass="139119" checksum="5CE48DDF9BC30347" modified="2023-09-13" version="1">MLKYHEEKDSKNSEHHFLIFDFEKDFCSSSAKITFSQPFNQTCISQTKENLVFVLNSDSLAVLILNSATTNFVDSLLLFGKFELAEFFYQTNNWDSNTLWSERAINLALDYQDYSLIERALSKFPFEKQLVIIQKMISYTNSNFSKFRPNFLQNLINLFQQKILLSISQYSEKILAFFPLPNENVNHLNLQQILILFASNLDNSLSFLNTNHSNQEKMQMELHKISQSNSNALILRKISNMIQIHPLSIVEKPKKDSMEELQQKMNEQIFHFVSQSILSSEEFHTYSIPQFISQFISSGKFSELISILQFYKNQENPLNLESFFRKEIDFISNLKRFSFEVFYHLVETNQVKEAFDLINNCQIKKESDIANELLLFTKNSVVRNNLLPFLYKDLPNIQSINPFNHDSIQNDLNFLLFLSHYYPNEDYLYYFELKTQKNYTEFPEIWDIIMQKAFIFSSNLEINFQPKLEIEEDFSENLNCGDLIEKSHLQFKDILNDKSEETLKEITQEGYFAFNLASLQNIHLNKRKRIVIEALNFQEETFTRRMSFFENIENQQEWLLICLDYIISHGNVFELKHFLSYIDDNYELNSKEIQAIQLYFSRFAPHFLRILFQKWFFKLSSVISYSQNYLDLQYLKLLCYHSLIFSNNQKKMEKLNHFRFKIHQLFVNLCIENQLINGVLLLMKHSPISQELKNHLISFLSKQTQSPHIQYLIQIIEEKFDLILLNDAKQEISDLLNQKSGDSKDQKAKLLFASFILSQNPKSQREKVSKMIEKSKQKKLISFFCTKSFLEKSKRNKMKNSRENHLFTSRNDTSLSQLIKKINSLEIDEILSKSNPFEELKSFSKQKFDIPFYLINTQTIKAIKTIVMNQEKSKMEIIMQKLLKENEQFWFQITSRISHLNLLDNKVFSCCLSFISFCGFSEAKFIVNHSSSKIIFIHIYAQEIDKESPTKKEYSFSPKCVSSSIQKIANLFKPLLFNDSKSFKKHKFTVYEKLLQAKTWIEKNKQNMEPFIENGLFLRSFCDKEILDKIVNNFSKIYSIDSRIFSKMGNKYTRSDLENVCQSLDFINRNSDSTVNLEENIQNVVLKDHIKRFLPELFPNSKTIEKTSVHKQDDISSFSVENIINWALREKDSTQMLIKKYCFTSTHFINICTCFFFKKSSKIINIFNFLFTIFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSS7</accession>
    <name>A0A9Q0LSS7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Morc family cw-type zinc finger 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSS7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="323" mass="39354" checksum="DECD7884D5AA60A3" modified="2023-09-13" version="1">MDLFKKENQNQNQDEDDEDLLQIFDKYTDANFVDSRIKIKKKKKKNKKNLEKKVKKQNLNFKNEQFKFEDFEDELNQNQNQIENQNQIENQIENEIENKIENQIENQIENQIENQIENQIENQIEIENKIENKIENQIENQIENESFDDDIEIEEIEDKKEKEEKEEKNQKKERKQKVEHFEDSEFLEYAINWPQRSSFEKEQSDFKFNLHLLPLDQLNEEMEKVNNELCLKMERMKNEYYSKNEPRNFLIRRDQKLTFDKNGNEKVLTILPPKEEIVKNNNENNNENNNENNNNENNNENNNNENNNENNNNENNENNNNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSY4</accession>
    <name>A0A9Q0LSY4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSY4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="103" mass="12162" checksum="722EACE3204B96E5" modified="2023-09-13" version="1">MDIRTDIQEVKKIVTEIFKDCIETCESNFENTNAKQSLVIKIEKFNWICDKLYSKIFHRLRMTLQCCKPGEFDETEYPNGNRKLDFEEPINENLVALKNALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTJ0</accession>
    <name>A0A9Q0LTJ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTJ0"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1105" mass="130821" checksum="A531A9A118CF2251" modified="2023-09-13" version="1">MGKHIKYSKIENLLNFLKIQFLKSTNLTDQENTYLHIELSLSSIQETSYLIWQLLIWGSIEITKNKSNINYNSWVFDESFHLYIEIPSVGISNNEFKLNNLAPFNYLEEKICQVDKKTFSFFSYKIDESSTIKREENVDLKILAKFFEIYQHPQDFESEDDVADFLFNIPNKENFFENSKKIISQVNQNQQITFRLLSNFWNISKYYMYPLIQYRFINPYKSKKAFADDKISSTFPKLFVENYQKNAAILVSKNIEWEKKDISLLIFSLEEKKKLIKNVNFISRNPNNRFFHREIQNHVSKYGFKFNEHLKNLRTNEMDNSKALKILSYLSPNLIEIHKKLIFENEYFKNFFTLDNFLRMILILYKLLTNIPIIIKTTNENLNSEFIQFLIENFLNQHLIIYHLNDKSNTKKEIIQTITEAEHFIYKNNIQTSFNILFEGIKFNSINCIALLKQIIFDRISNRSLISDKIRFIVSYSNFNEKQEFPYLDSFINEFEDFGTFNEKIENNFIYSMVSQAFTNLKFPKTNNNQITLIKIIFTTNIINSHKFIQKNLNQTCSLKDISRTLTIFNWLLNPKASQILFYEKEESVRIFYGMVVSLFINYILKLSQTERNKLESEIEKEIASNLNSKKKLTIKSIISDIQNKLINFLELDHYFPQIQITEELKQNLLIIFICYFSHSTLFLYGKSGLSQYIAIKILKEIDSKSGNQIFQKLELPSLKFFNIICSTKTTKKDIQNLFKSDFKSIQENQNNILPVVTLSNTQFLENNSNETYKILNFYLNLNQIYESDFEILSNEEKRKEKIPILIISDSQLKFISTFNGIELNISDNQESQLKENEISDILIPDTKKEEDNDNNDNNELDIPKISTIYLLKNLSFLPIFLKQFPTRMNILFSSQFPDEMKEYLNWKILKIELYASLEDLLFLCNGNEFLEGLCNLLTENYIQIGDNKFAQVTFGLYSKFIQIHSNFKLYSIQDVSIIENVDQSNCSKFIKFENFDLINFNQNEFITKFIDSHSTILDGIKSITKENIDNNNLIINYNDNLFLTLAIKFQDLNKNQPQIIENNNENNKKNDKDYIIFITQLKYWIRLLQIGKLIELNNYLISKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUD0</accession>
    <name>A0A9Q0LUD0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAj-related protein scj1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000050">
        <property type="protein sequence ID" value="KAJ5078679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUD0"/>
    <dbReference type="OMA" id="KWHEDGD"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040447084" evidence="1">
        <location>
            <begin position="24"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="320" mass="36399" checksum="745E355D1A880878" modified="2023-09-13" version="1">MKIQTILLSLILFILIFTEHTKLYDILEIKKDASEAEIKKAYHRLSKKYHPDLNPSEDAHDKFIELANAYEILSDPQKRKIYDIHGEEGLQNNRQGFNPFDIFQTFTQSFQQGFPFTFEFGGGSRTKKGVNLELELFVDLVDLYKGKIFWIPYTKNVICSCPKGGYNCKACNGKSTKRLDTELIVVVEAGMHSGDPIVFELAGDEEPNTIPGDITFILTQTPHQFFTRNGDDLYMKIKVSLLDALIGFKVSIAHLDGTTFEIEENTVTSPGMIRKYSGKGMPKRNFPSDKGDLLIEFQVDFPKSLTENQKKEISSIFNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVP4</accession>
    <name>A0A9Q0LVP4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVP4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="138" mass="17010" checksum="4C6BE671F8CDC8EF" modified="2023-09-13" version="1">MNDPKFSIKLIGKSGKIKLEGIVTLRKEYFRIKSKEYEIITKYNEIEKVFLKFEPQFQCFCQLNEKKLLKFDFEMKEDLLKFAKILKEKQKQFRDHKKEIIDQEEEKRIIEEFEVFFNEKNEKNEKNEKNEKNEKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVV8</accession>
    <name>A0A9Q0LVV8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acid alpha glucosidase relate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVV8"/>
    <dbReference type="OMA" id="YKGAVWP"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="82"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="464"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5079837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="690" mass="78933" checksum="DAF754DE5706B00D" modified="2023-09-13" version="1">MLNNGNDEDVNLYGVQPFYIELREETHLFHGVFILNSNAMDVTLNPDHLTYRTIGGILDIYIFTGVSIDDVISQYTDLVGKPPMIPYFALGFHQCRWGYKNLNECKTVVEQYKAHQLPLDTFWMDIDYMDAYKDFTFDPVNYPQEEVKEFSEQLHEDNQHYVIILDPGIKVEEGYAPYDDGISDGIFIINADTKLPYTAPVWPGECNFPDFTNPKTYSYWSKFIQQIFDEGIILDGLWVDMNEPDDFDFTGNQNDKLINSFIEKKEDEEELSESSESKKVERDSINLPYVPGGVNLNYRTVNLSSIQNTSTSFNLHSMYGFMEAKATASILIEIMKKRSFVLSRSTYAGHGHHAFHWLGDNYSTYKSMAGSIQGILNMNMFGIPLVGADICGFLGDTTAELCARWIELGSFYPFSRDHNADGMKSQELYALGDQVTNISRNVLLNRYSLIPYYYTLFYYSHEIGTPIWRALVYDFPEDPNTYSIDKQFLVGNALLVTPVLEEGATSVEGYFPNSDWYDYWSGEKILTKNSTLKFGKNLTLDAPLDKINVAIRGGYIIPKQEPALTTAESRNNSFEILAAIDSETLSASGKLFFDDGISLDTSQNSSRLTFELTYSSGLFYFETSIYESNYDLLNHVLLDKMTFYGVDSITTLWVNNIKYPFEYDSTLKVLRIKGLNLSLNERFQIIWKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVY5</accession>
    <name>A0A9Q0LVY5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polycystin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_03960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVY5"/>
    <dbReference type="OMA" id="AYERVHI"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin" evidence="11">
        <location>
            <begin position="181"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="10">
        <location>
            <begin position="375"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="696"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5079651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="735" mass="85177" checksum="8813A428A77FF1AD" modified="2023-09-13" version="1">MSLDSLNLRQLNTQIASKQHKSNMSYFKTLTKSTQKEEVKLPWLMGGGNQPKDNQDSRININDQQELELGELEVQSNSFTSDSDDETPKHHYAQNINFLATQASEKDSIDMKIVQGAYRLKVEKKKLRKELLIYLVFLALFLGYIFSQRPVETLWETTSGMTDYFFDEEFPNYFIQKTYWDIGSFDEIYQWAKGPLANGLQGDTDLTINGRPAFYESNIQIGAIRFRQARIKTGICNHPKDYDSFASDECFPHWKNSLKDTKPFGSPTSYSYTSQKDSNDPSEWGKLSHYEGGGYIVDIPFGDPNFTDYIDEMINSSYLNQQTRALFVDIHLYNPNANHFLSLVAIMEVGAGGCIIPWVQYRIFRLDLYSSASDYGRLVIELIICGFVIWYSYRLVKDFLAAYRYNSKPLRFFMSVWNCVDFVNIGLFWVIIIIQIVYVIAVKIKDLDLASINFVGIGVLGKQYMNFYSIISINIFLTLMKIFKFLKLTKRMNLLWDTLSEATADLIIFLGFFIIVFLSFAVTGFVLFGPSLTEFRDLSESLFKTFEMAQGDIEYSSFRNVNRFLGLLYYVFFVFLVIFVLLNMFLAIINQAYERVHIKTSKGLITQKFQQQLYAMKKFFRKLFGVCRKKKSGADKEDEISDLKILEKMTIISKRKSLGNLSTNDLQQLLGDSKEGRAIFKRIRSQANQSMKKLTVKKKEDKFKKLKELQEEIQDSQTRIQNLVQKIETFHPSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWC2</accession>
    <name>A0A9Q0LWC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynactin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWC2"/>
    <dbReference type="OMA" id="ACISKPR"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="97"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="382" mass="45356" checksum="407B4B3EA23D76E7" modified="2023-09-13" version="1">MELQKKLKDPEIFETKIETETIPKIRSLRPSEPFIREENPNEDRIESSIRVQDSLHFFQGKEIMTEEELKLQSLPEKIKFDVERARQRKKETQYEKYQRLKYEIESFTKELEEVKKEDEQILQKISIQNLQDLLKQMETKLEEVKNQVFTPNKNISSKLSEQIKKFPQNKEAAKPSKPETKQIKEDVVSYDLIYSDSLNNLTEETFLFEVEKQIIQLENIVGINQSKEQFVQKEDINTLVKKLKEKISLLDSIRLVKITKKIQLASRNLEVFDEQIEKDETLENSQKKVAELYEKMKEWDKVAQKIPSIISRLHYYKDLHDKQLALISRVIQLENEHKNLSESLSSNVQILEKLKKTFEENITTMKQNISLLEKRIQSISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWG5</accession>
    <name>A0A9Q0LWG5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWG5"/>
    <dbReference type="OMA" id="KEHEHIM"/>
    <dbReference type="OrthoDB" id="28186at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040416">
        <property type="entry name" value="TMEM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="7">
        <location>
            <begin position="172"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="521" mass="60973" checksum="775DFA4CD107425E" modified="2023-09-13" version="1">MIHSEMKMKVDGFRTKHIAALVVGYAIYLIVSVSIGAAGPEVIVERKTTENFAPTSNIELAEEIINLARMNLNLFISVELNNHKNYSIDLSARFNLNLGGKFTETGKVYSITKNSSHSRDIKCKPYSTCDQIYFVDETYLEYPIYTFSLIIEPKTTDTQLFDQATIIFEFYNTHFMVFKIIFAFAYVLLSLFLLIIWIYKTSNISWRVYTFEQKWLTILLFSLIFFNDPFYPSTVIVNNWLPEFLDVVFGTIFLAILLLFWLFMFDSFRYKPEQRTNFKFYYPKFTLVGLLFILVTALIFWQRLQMRSDANYQAMHDLPGFKGLAIGGIVLFCFYILWLIYACFRAFRARNQQNRKKTFYTFFFITLLLAILLIAYVGTGMIKDTNKSPMWVLSSYAMFNFYVLMLIFVFLPTQEVRDIVETGVQKLEDQEEDQQIQDDENLKNDIFKQDGLELSDINELKSNDEKNSHHESDNDNDNDNDNDNDNDNDNDNDNDIESLNANNIDQEKKKSNQNSLQSDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWH6</accession>
    <name>A0A9Q0LWH6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="1423"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="1544"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2040"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2086"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1372"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="14"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1375"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5080373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2252" mass="266348" checksum="B4CF12030D245AFB" modified="2023-09-13" version="1">MKIKIKLKIKIKIKLKIKNQIENQNQIENQIENQIENQIQNQNQNEIENENQIENQNQIENENQIENENQNQNQNQIQNQIENQIENQIENQIENENQNQNQNQNQIENQIENQNQNQIENQNENQIENQNQNENQIQIENENQIENENQIENQNQNQNQNEIENQNQNQNQIENENQIENQIENQIEIENENQNQIENQIENQIQNQNKNQIENQNQIQNQIQNQIQNQIQNQNQNQNENQTINENQIENENENQIEIENQNQNQNQIENQIENENENQNENQIQIENQNENQNQNQNQIENQNENQNQNQIENQIENQNQNQNIILDYSKNPKIFSNIFNLIIEMLHNSQPNQDDLVRLGGFSILRNLISKISPQYISKNTIKTIKKILIQIKNPVLIEDLVKNFILNFDIWINCDFEVQKSLIFKIIHHFFYHHSSKFQFIPEIKTQEVVDIILSYYLIETNILSRFKSISHKIESPNTKRKLTTSQILEIRKELLNGIQTIIQYSPHQENIIPLINFCLEMKHLNYEKEIEDVILFIYQFLKTLFIEERHLIQKKTSQDEYEELPQNLEENSSPIHTPTTRFEIKPEYDGFFEPKNENKKTTGNQYNLIFNILDSLNSFGFMDPFLVLMNTEEDVIRETSLKIICLLEWSISKFPKKKWENRFQLENGFFLIHNILTPFHFTRSICDSLFKAIISSNPLETEFRPQENASNIIKKIWVFDTIFQLMESENQSEITLLSLDNILFLLKQNVVNQLIFVRFFAWENKLFQLLDPNLFDDSQDININIDSENSSLTQKIHQRIFSIFYILQSYNFQTDKNGWKLFQQSLNYILLCNLKSTRNEANVIRKLLVVSIDIFRDIFKNKYHGQTFLFIRLHFKDSTTLFENFINFLEILYQFITIIPHPNPLSLDSKIPRSNSLQSVHSDENQLLNRYYGKIVLKKGLRIVDFFWEDLILVQKIMVFLDKADFFSIHTNPKIIKTDKAQVRNTTNQMISLLVKGIEHSQNNSLTQFFSDQLKKIMEAIITKKSHKMSARKSHQKKAISITIFSLFRIILKYEKEFFQESHIESDLSSLEQRKTLILQQRLNDKNNNNNNNNNNNDQEAFKVKAILDIFKQILIENYKFFYQTLKGSDKKKILPKFHSQNIFESISNADLFIMITSLDWKYSIEKYIYPKQQEMENQLKIQSKVVSNKFVQDEQNFKDTKSKSESEKIQFIESSGHQLQLFKMGLVSQENERFSQVLESQERKRRIVSSQWRRIMKSLTNERGTWSSYDLKQEFHWKIDRSEDHSHRRRKLKMNYHFDNHIEASIRRDQSSKEVADKMITEIYDKMQLEKLNQKSLRQSRFLDPNSLESDEEDDFYLEENTFEMTQETNQNQNQNQNQNQNQNQNQNQNQNQIENQNQNQIQNQNQNQIQNQNQIQNQIKKVIYKVNCELITPFIPISGIFEITNKSINFYAKNIDSQENTKYHEMIKFGDKSQDRSLELKDISEVHKRRYNFKQSAIEIFLLSRKSYFFNFTIKIRNRILRKLIHLRPPNLTQIDLGKPLEKFRKSSITKMWQKRQISNFDYLMHLNFISGRSYNDISQYPVFPWIISDYVSEELNLDDPKSFRDLSKPIGALDESRLQIFISRYKNMSEIDGPPPFFYGSHYSSAAIALFYLIRIEPFTTLSIKFQEGQFDSPDRLFFSIPILWNISLKGISEVKELIPEFFYFPEFLTNSNHINFGKRQNNEIVDDVVLPPWAKTPEDFIRIHQKALESEYVSQHLDEWIDLIFGYKQRGEEAVKAYNVFYYLTYENAVNIDAIEDEKERKSILAQIQHFGQTPSQLTLKKHPKRFPLEESNPIPLYRNLSLLTAITPKIIKINDYRIIFIHSADRLILFNRNQNLLIYRWNSANLDSFSKNITSKSKAKINKLNSDQKSSSLTKPRFKFDVKKFSEPLINSNNSENNSENNKIEIDNKIGDKLNSNLNTNQSSQTNQLIELESSLKATKRKIGVTFSFEITKLENCFAVSKNEKIFFSCGYWDNSFKLTNTENCKLVQSIIHHKDIVTCISFDENILVTGSRDTTVIIWKFNSKTGKINPIPKNILSGHDDEVTCVCVSEDLDIVVSGSKDGTCIFHTLRSGKYVRSLYPFAEDVRKEKNPSISLIKISKDGEILIYSENNLSIHLYSLNGKLLNSIHIFHHINCWEIIQNEKIIVTASEQGLLQFRQLWDLKLVHNFEFSLPISSLSISLDEKFIIAGFSDGSILIGSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXD6</accession>
    <name>A0A9Q0LXD6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_14562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXD6"/>
    <dbReference type="OrthoDB" id="188207at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040434221" description="Fibronectin type-III domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="898"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="512"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="613"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="952" mass="104271" checksum="E6503486F40E3E34" modified="2023-09-13" version="1">MIKNLILFQLLFFLIKTQLFVNETQLISNDGELNDNFGKSVSITQNYAVIGSPNSQVGNNPEQGKAYIFQKNGSNWVQYLTLTASDGNSGDNFGFSVQISQDENYIIVGAYSANLWNTSNQGKAYIFQNNGTNWIEKQILTASDGNSNDNFGYSVGISQDVNYIIISSPYANVSNNTYQGKAYIFQNNGTNWIQQEILTASDGNAGSNFGYSLSISGNYTIIGAPYANVGANLSQGKSYIFQNNGTNWIEKQILTASDGSYSDYFGYSVGISQDDSIIIGAPGVVYTNSSNKGKAYLFEMNGSNWIQNQILIPNDSNFASFGVSSAIFGNLSIVGSYGYQKLSEGSNGKGYVFEKMDSVWTQQLSLFPSDGTNGDYFGKSVNLYNSSFIVGASHANVNNNSLQGKSYVFTNSSSIPQVNIQSCVSLFSQFACYWNQIIGSNVDYQIYYDQQWISIQNPLLNNSIYSQLFNSSQYPNISGNVDYSIQIRACDSFMNVCGDASNPWNLTTRIDSVKNLSLSALLNSQISVSWDYPDVPLVNSTPKLDHYIISYQSNSSNQTQLSFPNSSKSAILTSNLLSNTNYSVSIWGCSNEECLNQNQGEIVSNSIFTLFGKVYNLSCSISNSINIECNWNQPSGSRIPTNYTFSYSSNDSNDSNSIQVTTTSYNFTALIPNEEYTINVSACDSNLNCGDISTINIKTKLTKPNILYWNGGIQEFQINFSKIERNYGYLISIDNGNTWNHFDQINESGENVYGVKDNIPGNVLYNVLISGCSESTCNISLLGPSSSSVSMIAKLGNIESLSCSAIDTSIKCNWNGLLLSEGLKGYCFSCNSTTEFLNSNQTEFTQNNLKEGEVYLISVFASALDNCSVSNYSGSPSTSLVQIFPPNPSTSTSSSSKAGVIAAAVIVPIVVIAIVIIAIVLIRKKKSHHKEIHQDMNLAQERLISSDQENLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4G5</accession>
    <name>A0A9Q0R4G5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4G5"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11618" checksum="B21E5FC649BF2F74" modified="2023-09-13" version="1">MRSELYRKMFLSVTDDTSNKVTDYSELSEESFQIFEYWIYSNQIKDEIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQNQKKKDKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4Q8</accession>
    <name>A0A9Q0R4Q8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein rabb1c-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_13184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4Q8"/>
    <dbReference type="OMA" id="TNATHAC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000263">
        <property type="entry name" value="Ras-related protein RABB1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="207" mass="23707" checksum="3AC22AD2882BE938" modified="2023-09-13" version="1">MAYRYLFKFVIIGDTGVGKSCILLQFTDSRFQPVHELTIGVEFGARTIDIKGDLVKLQIWDTAGQESFRSITRSYYRGAAGTLLVYDITRRETFNHLKSWLDDAREHSENLEIILIGNKKDLEHRREVKTEEGEQFAKKYGLQFLETSAKTNDHIEEAFQITAQKIHEKVKQGVINVDNDSTGVKESQTQKRKLTDEPNEKSKSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R587</accession>
    <name>A0A9Q0R587_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1426"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1434"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1450"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1476" mass="173536" checksum="67D228D4E32649FC" modified="2023-09-13" version="1">MIINSQPLNIFQKVSEITQEKVNEYLSILQLSIIWCKTINILKSPNIPTIQIDKNNWQTNIESINNISKFFQIKQELLQDPSKITTENKLNYFIPIMQQLLEILEPKNKEKTLESLISTTTKSNEKSLSKIMNHFAFGKGVYQVSVLDKEGKLEFPSKIKLTRSYYKIDIFHLGSHKFVYLPEPISRIIRKNTSENELSDSDSENENQECIIHLQTDDSLSFDIKSNNKNECFEIIKIFQMFQWYTGDKVENYPIHSQILGEETEFDALFSRICFQGHAYFQIEIVTKIHNSEKIEPGFLSVSRKYGLISSTSQKKVIHFGYKKDLVEIKLANSINESTLYLILRKKITKRIEILCKSKTQCDLILRCVTEFMNEDYQILYNKKPISSSLTHDPLATANDLTSFETRTSYVEESLKKLDQKFSMKSYFFSQFNKKGNPKVIQKQLHSPIINDFRLQYPYLQVVSSSIEEMQNRLKKFLVNQHEYFELVISTENGEEAVKMDISLNTIRIKNANENENENENENQNQNQNQYQNQYQNQYQNQNQNQNQNKNQNQNQYQNRLRNQIKIQPTNFSFSLNNNDQIIYIHEYKPNHLIFQATSFKKIVFLMKNSFERDLFVNIISLIRQMKTEKEHILTQRIEAEFHDYFLITPSQTQETKNISLNKKNEYVIEEILDGEKMTKLTSEDASVYHVSVLDSFRRYFSDARIALFQDHFEVIFGSKRISRNYTAFSKLFAESFGRCTEYQFLLDEFVFILVKFPSYEAYTGFLLEFHNLRKQVSPLIQSWWSSMKKYTFECIMQSSHENTPAQVTIESDTFTITTFQAFSQDDDSSEILDELDEFENYRVLQSDNQELSLSLDFSSIVQLNIVTDFIENDFKEKNFKEKSFKEKSFKEKSFKEKSFKEKSFKEKSFKEKSFKDKNSKNKNSKNKNPIQKIIQTKLQLLLGFQRFITLQFYNIIDLMTFKKIFIRTQNIYQIFLSNPQTLLQIEKNKENEATVNNMMKNDENLGECEISFYFGKMLVTESYTDQTTEYLIPNRTNFSFEKETYEKFTISFKTKEFGIENQIVQLEFQVDSQEKARDLIDKLVRFNSRQDFFKHESIEKKEMKIIFSNAIGAFRNGFLKIHPNGISIKQKERKIFKTYFAKFTEILYIPSNHSQTLKINFDFNTDFIIKFLSVEDLSAFIQSIRLSTYPIFEQHTLSKQITQPESIESKLLLINSLGNFNVILVNSEMNTVTPVVMRIINTSIEITNETTKKQNRINLQNGFQFTKSKNHLIIENNFQKTRFDFDERNLIQLYHVLLGLSVIQDILSVDFIQADCSIDGSPIQPVSILMDNNKLEISTQTSRNLVSYSSINLKLNSNKLIELYYFPDSDNESDEDSTDNSLSDASVFVFYFGDLQLFPEMFFQHILEMKNNLENLELIFEDLESGDSGQENDSDHLDVDSENDEKPKPGLRSRIGRKIIQKERFEMSGDHKNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R671</accession>
    <name>A0A9Q0R671_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Permease-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R671"/>
    <dbReference type="OMA" id="NHRREEY"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF304">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="269"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="460" mass="51408" checksum="FC3C9A3FA92FC7B3" modified="2023-09-13" version="1">MQTRNKFGWFQVLQIISAIIISLLCGAPNAFDKISSKIQNTEHYNDGFIQVLTSLEMLGLYFTIPAGFLHDKFGAKIASLIGGVCAVFSFLMATFIQTKASITFFFTLAGFGLGTGFICSLGTALKVSPLKYLGINMSLVGTAMSLSMGLVVSLYSLYDKVSGCSGDSCWKKEKQIQNLNLIKIRKIKIRKIKKKIKKMIKKMKKKMKKKMIKKMIMKMKMKMIKKMIKENDNEKEKLLSICVDEIEIIEEKKEDKASFKESLQILKNRLFWIYAISFFTGVGVGVFVIADVNLIWKSYNSSFDLTDLILTLFSVANATGSFLSGVFSDLLKKKNHRREEYLSLIMFISSVILLILGILTAVSKKGKTIDVFRCIFLIYVGFIFGTTLVLIPTMVGESFGQKNFGIHLGFLQIFSSTAAMAIPSISSGINNKTGHYFTLMFIFSGLTLISSLSLLIKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6B8</accession>
    <name>A0A9Q0R6B8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High mobility group protein dsp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6B8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="188" mass="22392" checksum="B862C6100F594757" modified="2023-09-13" version="1">MEQKQKRKKRKTPLKTPKKSAFLLFLQDQKAKILKKKPNLSGKEISKEGSKIWKKLSNQEKEKYKKKAREEQEKINEEINKSEKNGLESSSTSESEQEKKIPKTRSKFKIPKSVPLEKPLSPYRLFMIDTQKKNLEEFKGISVGEYSKKMSQKWIKLPEEEKKKFFDESKRQKENFQKLLKQNENQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6D6</accession>
    <name>A0A9Q0R6D6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6D6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="493"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="70761" checksum="53A5C535709C20A2" modified="2023-09-13" version="1">MNDCLFFGLNYSPKIIKNEPYKIKKPIQFKFENENENENENEKQIKQISSGYSGTIFLFKNGKAIEYLNDENDPNQNPSKIQIEENIQKVTVGYQNEAILTKEGNVFAKGKDINPNNPKEFINISSLIEDTNDRIIKDVVSGYNSIYLLTSNQNAYGIGFNEYGQLGLDFETLEKTQKPILMMKNVSKIFSGNSSDCVFLLNSNQELFGCGLNRYGQIGLGESRRNETRIQKLTKIQNIPKGKIIDIKCGSYHSIMLIENEIENEIENQNPKRKLYSCGYSSFNGLGKIYQDTYEFTEIKSYLFENDNIIDFSVGNRHTLILTSNSKLIGFGDNYYGQLGTGDTETKLIPIQIELPKLRFNEDISNYHVLCGYERTFLYYSLSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQNEIEKLQEIISKKSIKESNQIFEMIYLNRIINPKLYSEIKEIINSIEKIEETMKRIYLNENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVKDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIDELQIGIDYFQLNQTYPNLFDLLIRKFNNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6V1</accession>
    <name>A0A9Q0R6V1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="CIFKSGD"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="7">
        <location>
            <begin position="1728"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="2134"/>
            <end position="2401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1410"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2034"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1072"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1410"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2056"/>
            <end position="2075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2417" mass="274436" checksum="E4E2ADA44622F65E" modified="2023-09-13" version="1">MSSFHSKALNHLAKALAYSDPPSKQQVESLISLCSEYQSAHLDKRWTNSVMALANFLRLSKGMYLHEILPLILGKVKKVLDYQLQILSLEKMEMFIERIFAILIEISQFKNPKQDTEKNKENESNTKTAGSHIIDFIISSLSSSLKRIIQKTDTLKLLKGITEKHVKQDKKQQKQREKKEKKQGKHEKDEDEDQEKEEEKKDDQEEKEKNEDQEKKEDEKKEDQEKKEEDKEDSEEDEKQDEKEDKEDREEKEKDNINSDSKRHEALGFVSEFNAKEMSFAAFLGITNALATQSAMNMNHKQLGTLVHILLKTIKVLERLKKMVLSRITQTTASPRNARRKSQNLTHNVKWSEAAKTVAQFVSRGITTLRSTVVEICGKLVDLPQDICRPKERDRFGDIAEHILAAILGQARGQKARTKHGRARQLSAVLELIAKSTGNQPEQMMRSVTVLSEILAENRKLVTVLGTKKDDKNSVNAVLHTAIKCLSLVGQREARVSRVVVDALKTFLVSTPNPAFVELASDEICAVFRDERTGWNVQGISSFISSLSSELFGNWGQQLRTDTPKVPGNALVNIVIFLGKLSCEFGSIAELVAMVIKLLVSRLCNPKHPVDAVIVNQLTRIALIEDGQTAHLSKILSVFETIIKNSGDDRTKIARDEIPQALLQIAARVKAPRAKNRVLVRLVQLFIHKCEVISREATKQGISSSAMAADLGVLLPAIAAAVSGFREMKKALALEPTYSTSRPAIKYKKMFRSFWFYCVLHGFVVDGLWFPEWFAAITTVAQNIPALANRHKAHGQLEIGEELHSILDSHSSIGALKELRASLIGFLPKEAAIIAKLQFAQCTYLLAVYHLETLRAEHGAFHECFAYLEDEGIQNNQEHFACIKSIIDRAFSLFLGFVERLNRGEKRDNLLDYEAQFLLVNFCSRLKRVRLAAYKFIIQLVQRFPHILWSKCCLRTLLDLLEATAYSCEIEQIPVLRSLDSVDSYIKSVDYDPKIPNSGQTSTPQNQSSQLTSSPDSNSKTKSKSKSKTKKQKPKSKPKNKKQKSKLKSKNSAKSLAIPQQPQLQNQPQLKRGTSTSNLMQMPHSTLTSPLGISANGINSQGVARLLLGIGQNAYSAPQEEQKLSKFKLPHSQHTLDLLVGLSVRKEMYNSLKKLSAEWLRKAVQIAPTQIFSLTHEFINDFIGSNFVMLKHRGVGLLLDIIAETISPDAPQPTNRSKSQSKVGDSLTSEFVSAAELKSRFLGEIVGIQRTLDFLHATRNITNLSIPLSLSELLCKELSSLLSSNLTPNKLNSADLGPLFMKAAAFIVAEKRFDDDLLHYICWVPPHLFTSDAMSVGTFVWSWIAAERPDLEIQMMSELSAAWERIANQHAGIFYVESDFDPNSVQSPFSMNCFSDDENEVENLTENPVRNFPQNENIEQNSPLDQNTDLMGDKKDIKQGSTPNDLSSAFLKNAKPHTLWIQFLIERFEVVRRKNKLLMHVFQRILQRSFADPLGLSKRQECFPARMQLALLGLKYVQGDYMASRPAKMLLRKWIYRTILDWFSLRPIWHTLETKSSMQKTLGILTELAQTFQQESLVVNSFKKDYLAQSPIKERRDNDANINTPLIGGTSFDADNLLGFENMGVDPQTTQSNPQNYFTVTSSSLSVVMSVTKTMSMNKRFQDNAMLDETSLRNIQRQISEMRGVLKLIKLILFFLGDEIERISVWFNPRQDPELQFPDEKKYVPDYVALSTRGGSELKKMVTSAWQINPALAVSLSSRLNIPLIHDTLRRMVREHPLAVCHLHDAFQFLVDERSVTEDIPELHNLVFFPPVSPALALSLLVKPFSSHSLVAQYATHVLASFEPQMIIFFLPQIVQSLRYDRSGFVFKFLLEAASKSFLVAHQLIWNCQAESQSTTVRPNDVLKPLALRLISEITSSFTLQQAYLYQSEFSFINRFTHISGILKPFKTKQERKAKIREQLKLIQIVPNLYLPTNPESRVVRIHCDSGIPLPSHAKVPIMVTFRVQYISIAEQMREIASFEPPKDFRFSQNSLLVDIPDDPNQEKPNHIKNNSNISSEHDRSHEKSLDADKSHHSETQNLSNISDITDNSNLDNYAHHRSQSLVVDKNFIKDNPDLDFKNIDEDPLEMKRDSNLSIDQEKQVGNNFANMQSQTKRREFDQKCIFKSGDDIRQDMLALQIISFVQKILKSVNLKLFLYPYKVIATGDGCGIIECVKNSKSRDQLGKETEGSLFEHFKNKYGHEDSPSFRQARNNFIESMAAYSVASFLLQIKDRHNGNIMVDNQGHVIHIDFGFIFDISPGGDMKFERAPFKLSHEMIQIMGGSIDAEPFKQFMDYCCRAYLALRPHMKSFLAMVSLMFDTGLPCFKENTLKNFRERFTPDKTPREAAQFMIFKINESFNQYSTLIYDQFQAWQNGIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7H6</accession>
    <name>A0A9Q0R7H6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and socs box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7H6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="354"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="449" mass="53610" checksum="D7D980F080AE75DF" modified="2023-09-13" version="1">MKLLYIMLVKMKIFPLKLLNILLKKELILIQKQIIMKLLYILLVKMKIFPLKLLNILLKMELILIQKQNIIMKLLYILIICQNENISTQIIKYLIENEIDINSKTDNNETALHLIYNNETALHFACENENISIQIIKYLIENGIDINSKTEYHNKTALHIVSLSISIRRRNNRELIKLLLMNDANIFDLDQYQITKEFIEIFFQIYSINQDLNNLLLKSNEDNNFSDYQIQSNDGFKFNVHKLILLTRFDNNQIILNKFINICQLKKTKEEVELSLNFLYSGFYGFEQIYQKLNLEHFKDQSKQILLSEMKEKENKITKLFKEIGFDSNWIENKKGRKGIIKDLSKLYQQNETKDFTIIISKEKEIKVHKLILIIRSELYKGMFLNVQDSSNQVHDYSKKSFKTIYQLIYFLYHDKFEFENEINEEFSDLKDYFQLNQNSIIDLLLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7P6</accession>
    <name>A0A9Q0R7P6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7P6"/>
    <dbReference type="OMA" id="EFPGCIN"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040166358" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="371" mass="43583" checksum="A204399E62034AC8" modified="2023-09-13" version="1">MFEKFFGFILFSFLIFQYSFAKEPLRFRKDGTFQIMQLTDLHYGGYFPEDVQSDLAQQTYFETEGENTDFVVFTGDILAVFCQIPIVAWQRAVYFTNFYQKNYAVTFGNHDYTEFYLLDKLITMDMEYEYSYSQKGPENIHGVSNYYLEVLGSDSNETQLILYFFDTGDSDCEGVLGWGCVFHNQIEWYKNISNYLKEKNNRTIPALAFFHIPLPEYLDVWNNNICYGFKEETTCCWSQNTGLYQTFLEQGDVYGVFVGHDHKNDFIGNYNGIYLAYGRKSGFGCYEPELPTVQGTRIIKVQENSREIESWIRNKNGIKEIQKIHYPDEKDTQNYCLEHNPNPIPSSNGSKIHISSFFLFSFSFFFFSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7S1</accession>
    <name>A0A9Q0R7S1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7S1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="226"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="523"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="715" mass="85997" checksum="0BAA9761CC55241E" modified="2023-09-13" version="1">MNQKYFEFPCLVIGIPGSGRKSLILRFVNDYFVDDAWDWFIHEDSMRKIVSVDDDDDENMFLINYYQHAQIFMIVIAINQQNPNFDEIRNLILKIKRYKDIEDFNSITVILVANKIDRENQRTFSTQELQNFANENQMLFIEISVLTRDNVDECFFISARDSIIKRKLKEPQIEKKKKNFFGKFFTKKEKPKEPKLPDPFPKPTLELIPSTYQHDFFKMMNDKTFSDVEFIINFNLNQNQNENHSIYAHRIILYSRNEVFKQLIDKFEDDSNDLEEFCQKYFMKIRKKDSNQNQNQIENQNQNQIENQNQNQNQNQNQNQNQNQTKYNLSTNQVQIYVEYPYIPFYNMIKYIYCGMIDEKIMENQELVMQILSISDLFQVKRLNLIMKNILQKTQPNQNQNQNQNQNQNQNQNQNQNQNQIENQIENQIENQNQNQNQNQNQNQNQNQNQNQNQNENQIQNQNQNQNQNQNQNQIENQNQNQNQIENQNQKLTYDQRIEGLLTLEIDFMKNSFAKLIRSGSFSDFSIIGCEENKKEIVKAHLSILTQRCDYFKSLSQHQMKENIQKEVIFEDIGVESLFMILEYIYSDRFIPPNIDLAIRENNQNFISKSNKTILELMILSDYFQIERLKRLAQLNLSQTLNHEIIIQALHISKNTNSEFLKRFCYWEMGRNFLKFSKRNDFKKLTKEDKEEIIKLRFPPKEYDDYQKKYGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7Z3</accession>
    <name>A0A9Q0R7Z3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the methyltransferase superfamily. METTL16/RlmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7Z3"/>
    <dbReference type="OMA" id="GNENQLG"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017182">
        <property type="entry name" value="METTL16/PsiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037350">
        <property type="entry name" value="Mtase_ZK1128_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="297"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037350-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="538" mass="62366" checksum="8879828ACF966ED3" modified="2023-09-13" version="1">MNSKKNSKKKITNFNPRMHRNNYYKNNKPNFQELAEKFPSLKPHVFLTKFNFPTIDWKNEDSLRELTKALLFVDFGIKMEIPNDRIIPTITSRLNYIYWLHDLVGESEEKEISGIDIGTSASYIDEKSIRFARENIEKNGWSEFIKVRFMGNPDQIFTGIIEKDEYFDFSMCNPPFYENEKEKKDREIANRRATSGALFEITTKGGEKGFIFRMIDESILIQNQIKWFSSMVGRKSSLKPILKRLNQLNVTQIKRGRFFQGKIVRWAVAWSFFDEKDLSNNLSRSKKRKKDFDSHYLNENNLGNQLGNENQNQNQNQLENENQNENQLGNNLGNENQLGNENQLGNNLGNNLGNENQLGNQLGNNLGNENQNQNQNQLGNQNQNQNQLENENQNQNQNQLGNQNQNQNQNQNQLGNNLGNENNLGNQLGNENQNQNQNQLGNQNQLENENTNQNQNQNENQNQLENENTNQNQNQLGNQLGNQLGNQLGNQLGNQLGNQLRNQLGNENQLGNKLENENQNQNQNQNENQNQNQNQNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R853</accession>
    <name>A0A9Q0R853_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sesquipedalian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R853"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="131"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="463" mass="55306" checksum="5676DC40C4FFD92E" modified="2023-09-13" version="1">MSNKKTIVEGFLFLQNKKSSIFSTEPNEWTPHYFVLTQKELLYYSEKLSGLKGKIELWDCEILDPKVPEDTYALRLAPVENHEKSLFIQFESEEIQKTWTDLIQKTITEAKKEHYTSTIKKNQGNPQEDLKQLTTGWIQKKMKKSFFRKKEWKAFFMILVFDKTQAEYHLYIYNNEKIKKNPTEKIPLDIITNIEEKKFPNEPFGLFLKNNSKQEICFSFTSDLERKKWISAINEKIQEIKTGRVPKPEIKEEIKVETKEKSKEKPKEKPKEKPKVGFKDETDEIKDEIKDEIKNESNNEIKNESKNEIKDEIKDEIKDEIKNESNNEIKNESNNEIKNESNNEIKDEIKDEIKDEIKNESNNEIKDEIKNESNNEIKDEIKNEIKNEIKDEIKMNQIMKLKMKLKMNQIMKLKMNQIMKLKMKLKMNLIMKLKMNQIMNQIMKLKMKLKMKLKMNQIMKLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8D8</accession>
    <name>A0A9Q0R8D8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8D8"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="298" mass="35977" checksum="A8B4AC251AC8583C" modified="2023-09-13" version="1">MLCFNNNNNNNNQYKISAKQFENFSKIFLNSISQKNWLNWEWIIDKNVLQNENLYSNGFLCLSNYHRKIQNQNQNQNQNQNQNQIQNENQNQNQNQIQIQNQNQNQNQNQNLNQNQNQNQNQNQNQNQNLNQNENQNQNQNQNQIQIQNMEDENEIDEDLFENEIDEAICQNSISEFDFYNYQFHIIFDPTYECPILYFNVFTSKGRLLEIEEIWKQIPENYLKIFTKEELYHFISRKDHPIFQIPYYFIHPCQTTKFMMNMYQGIKNSQNYILSWLSVVGPVLGISPPIELFKIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8S1</accession>
    <name>A0A9Q0R8S1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8S1"/>
    <dbReference type="OMA" id="MEDHLTI"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="55"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="634"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="907" mass="107178" checksum="E9DD7D698AEEC991" modified="2023-09-13" version="1">MSVSVFEKYSKQKALIEISKEQIIHKAKYYNKFLKLILSEKSYLKILSKVADIREIDALTRSVVQIGVKTKTIFPIIRSLMKLEFQKVAESDSGSILRGNSFTTKMCSHYSQHVGSDFLLQVIGNVIVGTVTDQTLDLEIDHYTLEQDLKLDEDKLKQIISQRKRDLRLIAQLLFEKIVSEQNLTELPIGMKKISNMISEFAKKFAPNQVQQLVGGYILLRFFNSAIVSPEAFGLLPPEYSVSPRARRNLILITQLLQNLANLKKFYSDLSTINSEFNDFIEVNKDRMIEFLDRVSKIDENENQNENENENENENENENENENINEIDDLIQKYSLSFRDIQIIHKAFYDNMEIIKKIIDPNSKMKESIHLHIQDPKKCEKWNQRLTKLFKIISEIGIPPFSIPNIRFYPKYNFVTVNRHSLKNAYQQANFIYTDQLDSRHTIIYLIFHRVPDFFFNDLESIINFSIESVAHILNSKYSVIADLSFTFLSDNMQIQIEKIVHLLSTLINQKYTDHWFKLFSALSLPIKRKITEIYNVFDFEPFFPNFHLKLPNESKYFFPEVFPITKIDSKETKSIQLVKVTQNSLLDIDQKKWKIQKENLIEKINKIFVIEKEPEVLILFNKTNENQQEKTNENQQQNQQQNQQNQEKQQQNQEKVNENQQQNQQEKQCYIFRSIKERDYFIQSLFLRGFEFIPKLVTVFYSNGLKIQNQNQNQNQIQIQNQNQNQNENENENQNQNQNQNQNQNQNQNQNQNQNQNENQNENENQIENENENQNQNQNQIQNENQIENQNENQNENENENQIEIDDKTKRIIYITFDSIIFAKQKSLSIEVEIPYGVIKNIILDSTNNIENLVQIHFHNDSTIFYIQLKKNTLEFIESLTILLKNFQKHVSFISPNIFSQQEKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8W1</accession>
    <name>A0A9Q0R8W1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8W1"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="505" mass="58323" checksum="CF33116705F8DED6" modified="2023-09-13" version="1">MEKKQEIRKKQFKQKINFQNQQEKRTNSLESLRKAKRDLIISKRRKVSEIKNENFNWKNAQISKEFSKIEKGNINTQRRSLRKMRKMLSTSTPKTIQIFLSFGIIEILQKYINSADFDILLDVLWCITNIASGNTEQTKATLCFVPNLILYLESMNYKIQEQSCWALSNIAAEESLRSNLISNGILPSIIQILQNNQNNSLAFNAAFTLSNINRGDNPPVDLLFKYNISQVAKIHLNSTSSGIITEILWMLSYLTTKQLYFQQLFEYEISEDLVKIFGMGKREYVIPSLRSLSNICCSNNTRHLSLLLGYNSDNQMSLLDSCLKYLTSENLVVKKETTWLVSNILSGTDEQIQSVISFQNAFGETILSSVVNNFLNDGSIEIKRESAYVLMNVWSVPGFFQQHFNSLEEIDATFVIQSFLGLLVLEDAKIHQLVLYFLQNLIENFPQSVNILASFEIFNNIQRYLDENDETVCFLANQLFNEDKLNENERMKEIDIEIDLNLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R903</accession>
    <name>A0A9Q0R903_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Atp-dependent RNA helicase ddx24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_10353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R903"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="286"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="575"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="818" mass="96118" checksum="C9A62BC27AC808B6" modified="2023-09-13" version="1">MNKRNKRNKRKNNKNNQINLNKSLFLNEDSIWKKVECTDIFDGAEMEGFLSLEELSEDQYHSYFKENKNETKTEEEKEEKELKNKKKKRKKNRNRNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNRNQNQNQNQNQNQNQVNTKIGVFQVIETDEKSNQKSNQNSNEKSNQNSNQKSNQKLNQKSNQKSNQKSNQNSNQNSNQNSNQKSNQKLNQNSNQNSNQKLNQNSNQIIQENEEISSKLKENWSFANLHDDLLKGLNKLKFEEPMPIQKECIPVALFHNQDIAGAAETGSGKTLAYGLPILHKIISKVEFFKPFSREDLISWKNQRKLIGLILTPSRELTIQVSKHLKEVSAFNSWINITSIIGGMSSEKQERLISYRPEIIVTTPGRYFELVTQGNSYLRDLSDLSFFVIDEADRMFEKGQFKNLDYICQLLNPIEEINIPSDDPKNLEDSNLKDSNSNLKNLTNLTNWELFGKRQTFLFSATLTLKSSSFRFIDKNEIKKNQKNKKNEEIPNFISIIDVIHEHLRFENKLKTIDLTPDEKIVSRITEKIVFCLDNEKDIYLYTYLTEKKKGKTLIFTNTVSQIRRLVPILRLLKLNPFIIHAEMQQHQRIKNLENFEKSSNGVLITTDVSSRGMDLKNVETVINFQIPSNHQTYIHRCGRTARAFEKGIVINFIGPKDQKNYKKIIWNLNQNKNQEKLKVDQDYFHRSRKIVKLAQKIALSEKQKSAQKAKKEWFLKSAKELDMKLDDDIVESIKFEDEQTNIQNNPKRIVEMKEKLENLLRKIEYKKYRDQELNVFFGIQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9A6</accession>
    <name>A0A9Q0R9A6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9A6"/>
    <dbReference type="OrthoDB" id="10065050at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="422"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="615" mass="71936" checksum="4760A83909C88F4E" modified="2023-09-13" version="1">MTNNLNFFQQIPFSYQSMPNNLTQTTNQLQISMPNNLTQTTNQFPISMPTTPTQIIFIPVQSQTTSMPTTPTKFNTIRSPLMSNNPTPIQTINQVQSPFKSTSPNSIGTNTNQLSLEQIYQKLEEHKKLDSHLLEINQEIEKKNQKNFRKPKKIKKRKARGRNTHRRTDFVPNAPRNYSLGRHVWKYPPNKHQNFNKNFNKNFKNNNNNNYYNNFVDSQTRKPFNKRFSNRKAFSDHNPLSDELSPISNSYSYSSSSSDSNSNSDSNSKQNSKPKQNSKPKQNSKPKQNSKPKQNSNSKPKQNKKENYSLTKDYHSNKTINLENQVSPNKTFQELFINQNQNQNENQNENQNENQNENQNQNQIQKKKKKKKKKKNHTQNQNKSKMKQYIQNKDEEIQFFKSENQKMKHGMDFQKIFSDSEIIKKKGYVQKLKKWINDNEFFLKMKKGFSAKRDGFDCKNWHKAVDGKGKTLIIIKTTDNFIFGGFTQIGWTDDKSKWSRKRGKCTYIQDPDAFIFSLRNDKGDRKPDKFPIQQNLTKFAIFYRFSDNGPCFGKYKYKHGGRDIALSANLQSGWTDFGYSYNLPNGIEYGTNQAKKYLAGSLDKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9E6</accession>
    <name>A0A9Q0R9E6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Btn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5071994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9E6"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="331"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="502" mass="58312" checksum="B5843F8CF7FEB414" modified="2023-09-13" version="1">MESSENEKNIILQIKNNKNFPSASENENQNERENKSENENEAAQNLIETLSQKKSKSKSKSKLKLKSKLKLKSKSKLKSKSKSKLKSKSKSKSKSKSKFKTKSIQNSIQKNSNKKSKFAFFIFALFNNLYTNIFLSSAGDVLSNSNISKGMILLCDMLPMMIAKMFFPFFMYYFSYNTKVIFVVLLSSTGCYFAAFFKSTSLQLVGIVMSSIASGISHVIFLSLSSFYNEIISYWLYGTGAAALLGSLTYIALTEWIESTDEASLIIISFLPFGIILCYFLLLDRSVIKFQKYQKLEDDQEKIHQDEIEFENLNQSEFENDLDSSNLESDQNQNQNQNPNQNQNQNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQSENENQNQNQNQNQLENENQNQNQNQFESDLDSFENEIIKRKTPNQMNFCEKFRLLKIVLKYMIPLFIVYLSEYIIIVGITPVLYWSEPFSKSTFYKYFHLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9H8</accession>
    <name>A0A9Q0R9H8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9H8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="191" mass="21804" checksum="18C7F61F2A6C84E0" modified="2023-09-13" version="1">MPPKGSISRSRGRATPKSRVGRSATVKRKVYKAPKIKTSVKKPKTKTKSIKPLKTSAFRKSSAQTTYRNKSKSKQKEKKHVSHIYPLEMAKQDFQKAKGRKSIQKIREALNQPQNFQLVNSETNLKKHTRIDHNLMKKSGTNQKLTIEETKRAKQQLNVVTKIAPKLGTNVFNIATKRYENLKDPQGKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9Q5</accession>
    <name>A0A9Q0R9Q5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9Q5"/>
    <dbReference type="OMA" id="GRIMAIQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="113" mass="12478" checksum="B2EF6791A2DB0421" modified="2023-09-13" version="1">MTNLSQDTYSSFKDIWLGFVIWVVVIISLIYFIVGLVALNSVRKISGFWVPFALALIGAIFAFGYGSVCGVLIASIYESGPFLMTQKHLALYACGFSVLYLIVSLTRTATFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA95</accession>
    <name>A0A9Q0RA95_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA95"/>
    <dbReference type="OrthoDB" id="298084at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="172" mass="20028" checksum="57D839D6AF9795E7" modified="2023-09-13" version="1">MKKGFSAKRDGFDSQNWHSICDNKGKTLVIIKTKQNFIFGGFTSVGWTNDKSKWREDDRIIFRSVGFISDSNAFIFSLRNDKNDRKSEKFTIKKGKEEFAIYYGLEEGPTFGKYGDGDAEFCFYDSLQGYYSNFGYCYNLPKGIKWNTNESKDYLAGSYDDWIVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAP6</accession>
    <name>A0A9Q0RAP6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAP6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="185" mass="21102" checksum="D2B8B81CC3A4CECF" modified="2023-09-13" version="1">MNEIIFFGLNQYPILLKNEPNKITKPIQFKFENENEKQIKQISSDIQNQNPSKIQIKENIQKVTVGVGNEVILTIEGNVFAKGEDINPNNPNEFINISSLIEDKNDRVIQDIVSGYETIYLLTSNQNAYGIGDNEYGQLGFDSETLKKTEKPILMMKNVSKIFSGINSDHVFLLNSNQELFVMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAW7</accession>
    <name>A0A9Q0RAW7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="763"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="797"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1335"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1451" mass="167393" checksum="E0A52B5BC53A54E6" modified="2023-09-13" version="1">MDLLELIEDKNIEEIEKFEGDINFQDLEGKTALHLSCLSNNIEITKILLSKKAEVNLFDRNQETPLNNALKQPTSFELIELLIENGADVNLKDKFDQTALHNALINSSDTQIIKLLIAKGSDIKAKDSKRCKPLHYACMYIEDLEILDTLFYDQKQIHFKDQYQKTPLHYACLYSNIKCVKYLIGKGADINAIDKDRKNPLHFACESEKPSNEIISLLISSGTKPNLRDKRMQIPLHYLVMNESKVENIALLLKHGANIHAQNTSRQTPILKACEYNPNPEVIEFLLKNGANAQHNSYISTQSPIFLACTKHCNSKIIRLLFQYGAQLEFQSTIKKTTIQLACSKSTDLETIKFLVEKTGNNYFIRTSSHKSPFHFACENPNGKPILQYFVEMGVDPYSRDSQSLTALHFACISDAPMDILEYLVDDLGFDVNEISISNKTPLHYACEKGARKELIEFLLARGADTHLKDSQKYIPVFYEMLNNKRIEIIEMLIDEESMSHLPSILYQNMFLTRIFRYRMKFSNLKMIKYFINNFLDLNKTDTQGRDPLFYAIKTPVNFEVLKMLITDETNFDKHFSVFRAPYTYLSLALRSRNDPDIIKFLIKNTKDFSYTTSQNENYLHLACKNVVDEEILNLLIGKGIQINSRDSKNYTPLHAYLTTTFHQQNINILNILLESGADPNLKTDLNQNVLHLACYGFPNYEILKKLIDVIGKTALNELDSSNNTPLHKLCSNIRLKKNKKEASKMIDLLIENGSRLDSKNSQHSTPLHSLCQNSSSFSLIQSLIKHGADPNTQGQFSRNPLHVLLSKIQFNPKIIRLLVDSGVNINEVDSQKNTPLHYLIKRSFNLEDLELLCNSKIVNIQNNYGKTPLFSACEFYPNFEVIEFLIKKGSTVKLKTNNKKSIFSFVDWKTLDQEIVELLLSKKAKFSEKPARSPSSLSLAIVNSDEKLSHFLIQKYRKSYFSVITSAYLSSAKTSLLLQNHMIDFNTKIDNEPLFISLIKRYYESDFIKKIIEMKPNFQEKSLIGLYPIHYLCDKDPNPDILRLFIENYPDINLYSPRKQTPLHRISSVSNNIECYKILIEKGADVNCLDQRKYTPLMNACLNNASEKVLEFLISKGAELNEQNEMSKTALTYCIEKRNTRNAECLLKNGALVDFPVKKSPLYYACFLKDQKMVKLLLLYNAQVYDSENFVVTEEIQQILDSHFSICTDMNNLFQRQEFTDQNVQCIGGNFSIHSLIVKLRLNNGELNNQQIEQIFNKMLLILSKQEVEDAKIFMQFIYSGIFPKSKPIIESQKIVSEILSEIYEKPEEWIERKKGRNGIIRDLDILFQNQSTKNFTILFSNSNHSIHVDKLILVARSELYRGMFLSVEDDSNQVHDYSGKSFETVQKLVRFLYLDEINISSKNSIDNFDEFVDLIDYYQLNEKSRMRMVLEKTYDDLMKEERKNESNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAX7</accession>
    <name>A0A9Q0RAX7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAX7"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="711" mass="85179" checksum="0F1D5A017BA9F194" modified="2023-09-13" version="1">MSNLIKNKENDLKSDSKKKHKKHKKHKKENDLNILKLYVSENLSNLITIYLGQGSEKVICSKIILYQNSIFFYRLFKKQNWIQEYHFPELKLQLFQKILIFFETSKIKVDKNETIDLWITSYKLEIEKLIEKMNGKIIKLIESKTVIEIYLKAQEINSEKVIDHSLGFMYNSVEEIIDNPDIVNLSEKAIVNIIKKLRRSSDKKKEIILYKFIINWIKLSNSQKTIIKYWKRKQKYFELVNKILNFLFPDKIPDEIISEFHKDSFWKKDLNFQDRDIHFLFSKKRQINIQYQEELNINIIPENISNKTIPNQFEKPKNQNKFEKPKNENKFKKPKNENEFEKPKNQNEFEKPKNEKIQKLKNEKIQKPKNENIQNEFEKPKNEIEFEKPKNENKFEKPKNENKFEKPKNENQMIQSNFEKPKNENKFEKPKNENQMIQSNFEKPKNENKFEKPKNENEFEKPKNEIEIEKPKTKNQMIQSNFETPKNRNDEKSVVDHSKQTSDNKKYKFPECFIKSKILKENESEDWITRLKMWIDNQDLFDSFIPSLSYERKNKKDKIEGLNFHATCDDRGPCLIIIKTMNGYIFGGFTKLGWISDPERWDKTNKHSLANYGEIKDEDAFLFTFKNPKKYPIEQFPANPEQNQIIYDSRCGPNFGDLEIDDELMSGDSKNFGTAYSPPEIKNKKKLKGFLAKKQSWEISILEIYLTKKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBQ8</accession>
    <name>A0A9Q0RBQ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endophilin-a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBQ8"/>
    <dbReference type="OMA" id="NLPMDGP"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="42"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="357"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="656"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="810"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="962" mass="105183" checksum="8297FA47F408715E" modified="2023-09-13" version="1">MGLFGRKKKKQNQNQNEKQNKKNSQTDKKKQPTPPQAQEEKEEGNYVVAKYDYTANSQRELSFKKGERIRLLDKAGDWWRGAKGNLEGYFPGSYVEEVTSKSQGNSPQPPNSNLPTVIPPPIITDSMNTFTPPPPPTDISTEFLPPPPIFDDQSLPLPSPQSPTGQGFQLPPIPQQSGNRSPRSKSGILRSSIISNPIEPKSPTQRRNMGIRGQNPNRGPQPPPTGNKSPSPPPTKTQPKKLDQKKLSFLEETTESENSGKSNRNRSSTTVSVGISKQEHDSRKANIAALLGGKMPLGVRSPSAPKLRLSDIEIKPPDRIPDVSLQTVSTKLEQQKRDQSIERILEETLQLKDLDQDNFTKVVVVKEFVASGDGQLSLQVGQELLLFEDVGEGWLFGSPVGSEIKGYFPADVCQEAQSQEEIIAKQIEKQTETAHKLTTIKRPKRRATKQRKRQPTKKKPTKKKETKEEKSKIRINHSIPRSEKPPMEHMMKTLGIKEENEGEGLDFIHEVGVDGPKPPTDIPDDFILDGPKPPTNLPTNLPMDGPKPPTDIPNDFILDGPKPPTNLPTDGPKPPTNLPIDGPKPPTNLPIDGPKPPTNLPTNLPIDGPKPPTNLPMDGPKPPTNLPIDGPKPPTNLPMDGPKPPTNLPTNLPIDGPKPPTNLPIDGPKPPTNLPTDGPKPPTNLPMDGPKPPTNLPTDGPKPPTNLPTDGPKPPTNLPMDGPKPPTNLPTDGPKPPTNLPMDGPKPPTNLPMDDPKPPTNLQTNLPTDGPKTPTQFPRKFNQPPQNPKNPNQPTKQFPSRKPIPRKTPDNQTNPPKQKSPVNANQNIPSKQKSPVNANQNIPPKQKSPVNANQNIPPKQKSPVNANQNIPPKQKSPVNVQLPHVDLAKDSVRIEISGGQLTRIANVPQGTSDIVFAKDEKLGIEISQKEQNSLVIVIDSNSSVLGNVLFNKRRIPVQISLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBZ3</accession>
    <name>A0A9Q0RBZ3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBZ3"/>
    <dbReference type="OrthoDB" id="18687at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF104">
        <property type="entry name" value="PROTEIN SPRINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="180"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="328" mass="39059" checksum="D19B4DA04146C85C" modified="2023-09-13" version="1">MKKKSTKNQSTNQSKNEKKDQPNQKLDLLLENQPKINKNFQIGTYLTCTLKLSELKDYPKKLIYLDIKCIRIIFAEKTEFITKFQKTTLQFLENYISFLQKKPIRNFATKTHPIRMFIDKLRTKIIKKHPFLIKYFQFTEKIDHIDCQEVLNYLVERCLERVVITPIHNPLITSFHLESIKEDYILDEKMKKLYKKPPQFFGVANKFLKINWESPIEILSQFRICKFPFEFLDILINTADRIYFTSKRQLETLSQLNLEENISKDDFSITADGFLPIFLYTLVQTKLSNLQTIQNFLLDLSDPRELSSEIGYYLTTYCSSLKFIRSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC00</accession>
    <name>A0A9Q0RC00_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant sh3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="141"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="447"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="860"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1161"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1351"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1419"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="591"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1419"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1439"/>
            <end position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1661" mass="195184" checksum="8266EAA4871E8C13" modified="2023-09-13" version="1">MTSNKGIALFDYYSSFPSHLSFKRGEVIEITNKGEKFWQGTSLNSNKQGYFPRHYIRITADNKIIEEIQKQQKQQNDTTHKFQTIPTLQMNQAELQKSIEKNFSKKNTEIMEKDYTNLTPKQVVAFCPLTQIPQESLENIPIEKKSYVYKYRKSRTNWQKRIWQKRYLVLKNSSLNYYSNEATFNENANDYKGTINLKEIIFVKADTERLKKQNVLEVGTKSRIYFFQVNSEDEVNEWIVTIKLSQTFLGINLRINDQTDIVLFKLLLTYLDFLKEEVNKTKNQLTWLISKDNKAMQKQLTNAKTNEINQNLTTCRNILQSIYYWEIFLIGKLYKTHSQLYRSEHQFLVCYSKSRDEQSKDSLSYSKFDVIRVLKAYQDSEWFGEMNGVAGWFTPDNMLLLIPNLMDQSIPKAPTDKTNQVQETSNKDLKDDQNTAQYNTYIFEQLNIFYAKELIIQEKKGKNFKWITKWVVISNFYIFIFGAKEDFIPERTFHTAEIRSITSAEAKLNVPFAFQMEMNSTKVNFCTPDKQSMEEWITHFKRLVSLFLLSNINTKNPVPYNQRAFYEEEAERLIIWIEGMFSEEKQTLDKYHNLESKLAKYQIIKDNQNQNHNQNQNQNQNQNQNQIENQNQNQNQIENQNQIENNNQNKNAKKPIESIHLLQSAQTEKERDISNQMLFIRQKIMATENQISVIKSVHYYLLTISARINFPELMEKEIGYSFISNIPLKNQEELSFVSRQWFVNLKEENAKYLRGSSGGLSGLIPRSKILIVQPVNRMLISFKTNLQFEKYSYGVQVENVMSGTKAVNPIFEIAKKNENQQQEDAKRAQTDSTKQVNEASIAKGLLKNVIEDEQTREIFPVNHEGYLQTRNKKNQWEKLWFVVRGWFFGSFSSETSNDPIFAIDTRSIVSTQSVITSGKNQPKYIFLVRFNENEYKLFAVENEQDLKKWLFVLHGIQVVVEFDSQDNASLTKLYYEIACLKRRTKQLILIIEWISEMESKFGTEDTPKKQCLLNWKKRFLASEAKRVIEKPDDYRTRIFPVRSYKEAKDNEISFKKGQWMILIRKSVDSWMKAQLGKDIGDVKEDSVEIVEITKPTKGSLQAHSEIGWDMKQLDRTDNFLAFSTSRARKSYLFHPRPSGFQSVNSISDDVIKNIPIFQEGLAYLKGDLFKTYKRFHRKKWRKKWLIVNGWDICVFSHRKDILAAPKISTTFLAIEKIEKTTEIVESKYSFRVTTENDTEWIFGFDTTEELKSWLNVFYIGRNFVNILKKPLFPQKELLIQFKPRYLKLISWLEREFVQESDLLSKLMDPNSLDESIKEQVEKSQEWISALQNLRKTLLSRLCRLLIQEDSDLQRRVFCLEKYQAKTNDELSISENDFLMLVDSQSAMWIVKKDDGNQGKIPANHVEIVHPCSSLIFQQTHSSQKGSFSNPHGHQKQRSFHSQTNDPNKTMSEFQLNRSNSEKSALFTNSNQNTNNPDFQNTTSKDSRSETTGDFSQTEDFQEWEMVQNDNVLSNEEYQNMDNSNYYYDDSNIAQTEIQNELFLRSKKRKYAMNVSIFEDRMLLNNSNENYEEKKLSVKLFRNAYSIDLNTKNAKIAIDMASEFMRNWEASRNEDLLSIPVSYSGNLVMITNKKKESWHVVLQRMDSLFLPFQHVQEAVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC10</accession>
    <name>A0A9Q0RC10_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Defective chorion-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="YQHQYPN"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="1400"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="636"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1504" mass="183973" checksum="09756AE314B0CECE" modified="2023-09-13" version="1">MQNQNQKDINKDVVSNQRFSDLQPKQLYINKSVRNRNRNENERFQGNIRHQRYQENEGDSRIDRYRDQDGFNPNYNPNYNPRYNPNYKHRYNPNYNPRFQRNQMYQRGYGNYGYNPRYKREDNFTHNQRINRDEDFDNHNIRNEENKFNDFKKEKNEPNKWNKTKDDDWGKEQKIEDKNINDSQTEQKNIPDNNNDNDNDNGNDNDNDNDWKDTKKYKQEMQREFQDRNQRFQRRDRDQDEYNPNYNPNYRSNYNPNYRSNYRSNYNPNYKHRYNPNYNPRFQRNQMYQRGYGNYGYNPRYKREDNFTHNQGINRDEYFDNHNIRNEENKFNDFKKEKNEPNEWNKTKDDDWGKEQKIEDKNINDSQTEQKNIPDNNNDNDWKDTKKDKKEIQREFQDGNQNIQREKQNKPNIINQEPEIKHEYEPNPRFQSRTHKNQNQNLIESESESESESESENENENENNQISNTNEIQNENKIQNENNQIPNTNEIQNENENKNNKIQNEIQNRYQGEYQGEYQYSYQDSYQDPYQDSYQYPYQDQDQYQDQYQDPYPYSNQYQYQHQYSNQYHQYQHQYPNQYHQYPNQYQHQYPNQYQYQHPNQYQHQYPNQYQNPNQYQHHQYSNQYQYTNQYHQYSKQHPNQLQNQQQNQLPNQLPNQLPNQLPNQQQKQQQKQHQYPNQYQNQNQIQHSNQIPNQLPNQHPNQQQNQQQNQYPKQIQNQYPNQLPNQYPKQNPNQHPNQIPNQIQNQNPNQIPNQHPNQHPNQHPNQHPNQIPNQIPNQIPNQIPNQIPNQIPNQIPNQLPIQNQDPNQLPNQHQIPKQLPIQNQHPNQLPNQHQNQLPNQHPNQHPNQHQNQHQNQHPNQHQNQHQNQHQNQHQNQEQNQIPNQHQNQQQNQHSKQITKQIQNQQNQFPKQNQYNQNQNKQIPQQFPKKIQNQDQDPNQDQNSNQDQKQFSNYQNQNIRYRLKQHPNQKMEQVIDEKRNIEVQNQNQNQNPQKFNQNRQYNQSFRKDYQPKRIVYYQDSNEQTNEDVTNQEEYYQRKQYYNNNKQFHQRQRSPNSNEKWGHDLFHQQQQQEFDEQKYFQENSFRQNRPNYREPYRKNRDFSPKSFESQNQYQMRNERFRNKSPQNYYYNNYNRNSPRMRYNQQYNNQFQDRYYQNSPPQHFQNQRQIITQNSDQEELPELIIACRNREEEKIKQLIKNGMTINDRGKNTPLHEALDNKCSYEIISLLISSGADLNAKNGNFPIFYACNYNEDVTKLLLDSGADISSVETITTFCKDPSIIELIQTYNSILEDMENLSKKAVFSDMKVETKNGAIHLHKTIVDFRIGNTSDFEKTLLKFEKEKAKFIIEWIYGKRPFNFDIELEIRLFADELKIKDWKNLSGRCGLLKDLQRLYLDENSKDCEIVVDDDSIKAHRQILVARSAFFEEVFKGNSRKYIIKNSFAFETIKELIRFFYYDEISPNLPQNVLLELKKTIYDFSLNPNSYLIHLLNQQNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC40</accession>
    <name>A0A9Q0RC40_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formin-b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC40"/>
    <dbReference type="OMA" id="PISWITE"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF4">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="2">
        <location>
            <begin position="33"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="462" mass="53317" checksum="F05640AA5A787059" modified="2023-09-13" version="1">MGLFGKGKKKKEKDKQTETNEQSRPKIQMDSLPPMPPQDELNDMFSNLLTELGVPDSKRKQMEALANERKWLLLFQHKSKEEEKKFKKSTGKEEENAPKTFIDRVTQELSLETVSQLRTALSSNPISWITEFVNHNGLTVLFQKLEEVTKSSIKTDQDWNVQHELIKCLKALMNNQIGLEAVLSEQHNIFKIAMSLNSSKWGLLTTVVELLAAVCLVPPNGHKYVLESLSFVREYAKQKSRFSILMSHLQRSTKDKSSLDFKVSVMMFINTLVNSPDDIFFRIELRKEFAILGIRRMIEKLKSNKFPELQTQIEMFLEEWKSDEQETGEEIHDIPQRNENDPDEVFNYLKDNIIHTEYEKHFMSLLNSLCDASYDTSLDIWSTIDALTTRTIELAANREEDAQSLLFLIQGQGESDRIKELETYVLRQKEELEELDKNISAVVKAATLKMNELTTIIKSTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCF8</accession>
    <name>A0A9Q0RCF8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCF8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="420" mass="48281" checksum="A69549D4E488040A" modified="2023-09-13" version="1">MFDDFFDSFGFENSTSDSDGIFGDSTYKLTETNSQFISNQNNYKAIVIDNGSFEIRSGFAGDDLPKKNTRNIIGNLINESNLINLSKSQYIGNEAQENKEILNLSYPIQKGIIENWDNMEKMWHHIFYNELKIAPEEHPVLIADSPFNPKSSKEKIQEIMFETFNVSGFYLANSGILTLYSTGRTTGFVFGIGHEITFTEPIYEGYESSNIIDQYQFGGNDLTNYLIKLLKEQDYSFDKSNDTEIARDIKEKLCYCSLNFQQELNQNETENQNQNETELEDIYELKNGDIISISNERIKCCECLFEPKIIGIDLEGIHKLIYNSIMKCDISSRKDFFNNIILTGGTTLFPNFKERLEKEIKQIIPDKMKVKIIADPDRKYSSWIGGSILASLSTFQNMWISKELYSESEDEDMMSYGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCP0</accession>
    <name>A0A9Q0RCP0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCP0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="583"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="687" mass="78741" checksum="9AD3A46C785074DA" modified="2023-09-13" version="1">MSKQFIKYLNERKEKQILDLLRRKPSLAKIKIYEIPVLMYAVSSNQSLQVIKAILDSGVDVNEVDTSNSTALFYACRYDEKLEVVRLLLERGADPKISNNESPLFYAVQHCSESFQIPQLLIDKGADSLQISISNIPLHYAVKKANDPKIIQLLVDAKSPINQLNDVSLIYIKIQNSILFLSSKLIYFFKKQNETPLFLACAADSKVDIIKVLIENGAKSNSDKGTSLLSILIKKSAPSEVVELIIENFNLNEEFTNSLPYASKFNEGTEFAVACTYSKNPELIKLLLKHGGNPNIKIKIPCVHRACKNSVDIVEVLLEKNVDLELLDQGNTAFFYAATHSIEMIDLLVSKGANINAKNGNNVLHHILSRFPANGELVEKLCSIGVDINEHNNEELTPLILCCKNNQQLPIFEILIKYSARIIDYDIQNLLKYYLEDHSTLNFEIIKLLFSHGGNFKNLENTDQRIFINSKEFEQKQYQIKEIERFFEKYEQIQQDFLDLLDEKDLSDIQIKTLNNEISAHKFILEFRLGIEVEKISEALINYEEENVKAFLEFVYSGNVLDKNYNIILGIAEKMGISIEKINKMILPFWFKEEKFPVHKWVLIARCGLFRGMFLNVKNDSSGEVNDYSQKSFESLNQFIKYLYTDKLDNSISNIIIEELSDASDFYQLNEKSDFEDQLKTIKQGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD48</accession>
    <name>A0A9Q0RD48_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD48"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="57" mass="7136" checksum="02A930904478A2F6" modified="2023-09-13" version="1">MEKEYIEKYDQLIQFFFNITTNQFTQIKKELNQERLMTQIIGHWFENDFTFQVCFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD62</accession>
    <name>A0A9Q0RD62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD62"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="210" mass="24180" checksum="D9503064074F8EF0" modified="2023-09-13" version="1">MGRRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDTGKKKAKIDEFPFCIHLVSLEREQVSSEALEAARIAANKHMVTKAGKDAFHLRIRVHPFHVLRINKMLSCAGADRLQTGMRGAFGKPQGTCARVKVGQILMSIRTKDNFSKQAFDAFKRAKFKFPGKQKIVTSTQWGFTKLEREEYEDLRDKHQIIEKGSHCLLFKPKGPLPLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD91</accession>
    <name>A0A9Q0RD91_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD91"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="16695" checksum="9FF619E4294F50D7" modified="2023-09-13" version="1">MNEILFFGLNKYPKFLKNEQDKITKPIQFKFENENEKQIKQISTGNYSTIFLFENGKAIEYLKNSKLNPSKIQIENIQKVTVGYQNEAILTIEGNFINISSLIEDTNDRIIQDVISGYSSIYLLTSNQNVYGIGSNNYGQLGFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE18</accession>
    <name>A0A9Q0RE18_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE18"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="929" mass="113387" checksum="929B7F3CDC4E562A" modified="2023-09-13" version="1">MRNKKQKKQKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKRKRKIQFFFFIQNSKIKIGKEIQKATSNGIQKATGKGIKTILKSWDNPKIQYHPKIIFIYVEKILKYNKFKTHLKLKLSKISFQFSVQQLLRQNTLFLFPKVIEDYKKIASEMIDTCFEEFLSEEFTSKEKEKESIFNFAISIRNLMNHNIFKKQNIETKEISKVRYQEEKEKTKENESIEPKIQKGNENVQPNIQKEKISEMEKILEQELTNQILKIDKNYKEIIEKKKEIKINFTDVIDDFLQISFKTKFLNEMLGKKLLYYLLFDMSLFRKIFQIRIKFTNLFIIDEKIWNLQFFLFLPDYLRFIQREKKESLLSQFSPEEMSQEIYTFIKSNKLDKVHFELLFKNLHLFFDDKIYSKTQELKRLFSENFFNDAFKDYLDSRFDLFITQIFKNLQFTKMEEFYNFWRKFLLKIKCYPLHNYEEKKSIKEEFTNINTFGNLNWSEYYFNDKQEQQIEYWFDFGNTINNKLYQDYYEDEDFSESDYVNDKEFHDQFKDLDPNDFQEILDGLDPNEFQEITQETLNNLQKKQKNRLISFQKVIFENFYKQKFISEKDSIQKLEIIFDPNTFKYLKFFFHFIADDFFLFIQSIFQTISKQKIIQNDKIIQSIPSYMQFKLFENTIKEIKFTDDIKTILQPEKEDTNNNNLKLILEWRIKLDKSFNQIPNSDLKKEIQKIYENFQKYIKDTNNHSFIQLENLINQSFWKCLEKFSPEEYKNNQDLYEELKNQKQLFEILSGYYSQNEQKIQKIQKINEIFEMFNNSKISISEIQKQTKDKKIDKESNIGFILNYQKSKIFKMDILDTFFQITPEEDIFNQLNQISNYQKTMIQKFKEKFDYIFNQEITFEEIDQILLNFTDISLFKEELEILESFSNSNKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REC9</accession>
    <name>A0A9Q0REC9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Mevalonate kinase</fullName>
            <shortName evidence="13">MK</shortName>
            <ecNumber evidence="3 13">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_05690</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 13"/>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REC9"/>
    <dbReference type="OMA" id="KEWSTII"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059231">
        <property type="entry name" value="Leader_pinensin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038180">
        <property type="entry name" value="leader_pinensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="14">
        <location>
            <begin position="93"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="15">
        <location>
            <begin position="266"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5077591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="354" mass="39677" checksum="3AA87F4D80733CD9" modified="2023-09-13" version="1">MQIIESSAPGKIILFGEHSVVYGKTAIAVSINLRTHVKIIPYENETEKQKIKFKDLKSSQKVIFEIIQNNIQLKKWNCDSKTPQVFAVIFKEIMKEKILKPILIEIESELPIGSGLGSSASVCVSLSAALMKFSGKIEIDQNGKITKQSLQEINKFAHLGEKIYHANSSGIDNTVSTFGSILVFNKNQDPKFYNISKLRSMGILIIDTGIKRNTAKMVKIVSDLYSKFPKVVDKIFESMNQISLESIENLENFENLEEEQKEEKIIENLQQLTELSHCLLNSLGVGHPKITEITQICNEFGIKCKITGAGGGGCCFCLFSKNQREKIEKIMLKLNQIKIKSFITSLDKEGAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REE9</accession>
    <name>A0A9Q0REE9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-finger c-x8-c-x5-c-x3-h type-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REE9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="705" mass="84325" checksum="5C95FB6F692BD4A2" modified="2023-09-13" version="1">MNDKQSNNSIKNKNPNLIQIPQEFLLELNQQQIKNPKIISKFNGLMQKYQNNQLNIESFLFKGKELFQQDKNLIEKFEKIVEKEINKELNPSNQNEKELITNLKNSFQNDKKSLNSFELLLDQFQNNKIPEYSFRKEMFEIFQENRTLLDMIDSLITIQTDKWKEMQTEDSNNKKQLKKEEENKQERGGLSNTQKQNEESPTHPNPKRPRTKKATPKKVNSSNTTNTQTPRGRPPRGRGAGSLSRPSRTPKTQQPKRVVSKINEKQIKQKLNSQILEDPLITKEEFAYEVIKPNPNSIQIQPFGKDELKIDNKDWLIDKDFNESFNHNLKFKIERLKNLLQFHSRFVTNMLEVLKIIESIQNQNQENQNEENQILDIQKRISKIVLKKQNYQVIQSSFFEQTEHYIGLMKKDPLLYLPFIFHRVVDNFEQLTKIYENLRNEWNRNIEKNFREWNDFYSFSFYSFCEEYYNERNTLSKINLKNSSINHIYHDLSIFEQISLLLKNIEKNFTQIKDILSNKKNPQSIKEHLTPFYYYLYGKFFNDSRKNNQEENNNNNNKNENENKNENENENENENENKNENENKNDIENDIENENDIENVIEIENDIENENDIGLDNESFKPKFRELQNLFENFLFFFLFKYQKVNKENSSEKNDNESDQNTDSEMDTESDSNQNQNQNQNQNQNQNQNQIENQTKIKIKIKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REW4</accession>
    <name>A0A9Q0REW4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REW4"/>
    <dbReference type="OrthoDB" id="7628309at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="251"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="349" mass="40820" checksum="79D6B75620FA2DD7" modified="2023-09-13" version="1">MDPLDFIRAIDENDLQKIKEIYQQKPDFNDLFPTNHMTPLDKALRKGASEEIIRFLLTTEKIDINAPNGDTAVHHACWFHKRTNIIKLLIEAGGDINYKDGIQVKKFIFLLADYNGDFTIPDKKTPLDYVKDEKLKQKILNRIQTRKSINQDFLVLFERKEFTDSKLQLQDGEISFHKLIVKSRIGEKYDSLMDILQNKKKNEVEDFLKFIYSSIFENSEVINDILNQIGIQNQELNVVNYEKLYQEEESKDFKILFEDGVVLAHKIILIARSDLFRGLFLSVVDESNQVHDYSGISKDAFNVLIKFLYTEKLDSNIPQNILQDLQEKIDYFQLNENSSLDEKIKEILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG14</accession>
    <name>A0A9Q0RG14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mammalian ependymin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG14"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040254666" evidence="1">
        <location>
            <begin position="16"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="244" mass="27664" checksum="B637877037B344E2" modified="2023-09-13" version="1">MKFFAFLLLIALAFAPDPPKWPIHFATELDVIHYHNRSHTFAIWYYDYNENAERVEVMNYHEGMDVTMINDYNAEKQYVLIETEDDIICQTHDLTGHLFYPDLSSFVYSGQRTIRDKLCDRWFHNATRMIYYDTHDAPNEPMQIDFMDSNQTNFLNFKDHSVDPAYFDKPAQCTDTTGLSCDACESLGEAAIELGCDASAAAISALCGPFAELCEEAIDLACEGACSYEECAEKACCALGFCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGJ9</accession>
    <name>A0A9Q0RGJ9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGJ9"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="9">
        <location>
            <begin position="501"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="8">
        <location>
            <begin position="704"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1204"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="236"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1076"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1204"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1233"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5078823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1246" mass="146081" checksum="23A2DCBF7B01007E" modified="2023-09-13" version="1">MQKSISKDKIDSQIVDVPLTENVDSNPIQEDSQKVDDTMENLFEISVKNDSNDFNPFGNDFDNKQNEFGNEFDNNFDDKGNDFNNDFNNDFDNDFDDKQNEFGNEFGNDFDNKQNEQQNFNNDFDDKQNEFGNEFGNDFNNDFDDKQNEQQDFNNDFDNKQNEFGNEFGNDFNNDFDDKGNKQQNFNNDFNNDFDDKQNEQQTVINNFDTFENDDQDLFNYYDNNEYLQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENQNQNQNQNQNQNKNQNQNQNQNQNQNQNESENQLENQLENPPLDDLSSQFGNISQDYSNLLFPVHDMDNNFTTDFDNTDNAFPDFADEDNNEDNNEDNNEDNNEDNIEWEFNPYELKTEQQFTPTIFSTVPTTSTTLSPKVIDFTPNNVTHGQPINYHHNDNNFESNSFEDVSIFGESPDKMPFYGYSQFNQQYQGYQNVGNSNLYSQNSMTESPTHFTESYKQQPTETIDPKSLFYPKQHPIVNFGFPGKIITLIPKKKIHLNKYEKETNQKFEYTKTKSITITSLKDHLPKRIIQGFEKFPGPLIYSKPSKEDIREFFNLKIDDEDEDFDKAFTHNQIKQQEDISEKENTKLLWKMLKVLIKFKGIVKSGQRKKENENDQKIPEKAFAKYLIPNQEEEWNQEFTEDKSIYNENKHSELIKKSINQEQDKFDSKKLEEVTLQIQNHLMHGNQKQALELSVSYKLWEHAFIIAGRCDKETYDNVIKEYAQKNFVNGSPLQCLYLSYSGYLDDILNAPTQNYYIFQKQKNEQEKEKQFQDRKEFEQLIFDYNDEKYPNYYPNNDQNSEIASKILSKWRESVGILFSNVSYPYQNSVEKIGDLLLTKFRHVKPAHICYLLSDIPPKALSNPQSKYVLIGSDHRTNLRTFINPESIQMTEIYEYAKRLSNSQFLLPHFFPFQLVYCYDLIDMGMLSKALKYCESLIQYLRSVSRAQKQFLDTFFTSTLQDLDSRIRSVLGIQESSNSSTIFKTLAKVFDSTTVWLTNINSKTENKQKPKTQSNYEYQPQNLNYQKEEIENSKNNFQNETIPNNFYSNQPNLNSNLNPNLNPNLNPNLNPNLNPNLNPYGKHYWKKKADLGELNKYYYDKDLKQWVLPGEKKEEKPTEKSSEKPTEKSTETISTPTISKPPSISTPPISKPPSISAPFSGFGIGRDARSRYVDLVKENSITTQTQTQNSKSNSKSKFNSNSNSKSKSKSESESRFEQRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGM5</accession>
    <name>A0A9Q0RGM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGM5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="306" mass="36626" checksum="D09FCD011229813F" modified="2023-09-13" version="1">MFNFITNFYNQNNIQLLFNDEIFPKKFENQANEILKNEKKWEEFYNKNIKQKYEEENEETNFQRNLFSHFQREYTNHLVNKSMFGNDEDHGIFQTYEYEIEKIVKEKKEMNGTLNNNLLDLESDINTPKYTRYDEIVDKIYFKNTRDEREARKSYLTQQKQLQKAQALSNIPTITTLLNFDILGKVIDLPYVSDPQVLFIGYDFANDNNFILQKFEEFCEKLILEKPIKLNSTVIHYNSVEPLAVTFFANKGREFIEKFISTMKMFVDKSSSNPAYIDYWKLAKYCLTNIGSSISDLQRYFSENKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH69</accession>
    <name>A0A9Q0RH69_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000031">
        <property type="protein sequence ID" value="KAJ5079498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH69"/>
    <dbReference type="OrthoDB" id="61627at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="25"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
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            <begin position="231"/>
            <end position="265"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <end position="300"/>
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    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="301"/>
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        </location>
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    <feature type="repeat" description="ANK" evidence="3">
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        </location>
    </feature>
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            <begin position="372"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="513"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="548"/>
            <end position="582"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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        </location>
    </feature>
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        <location>
            <begin position="973"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1211" mass="138107" checksum="B07B99F89FC59059" modified="2023-09-13" version="1">MNKDIKDIQDIQDNKDNKDNKDNKDIKDNKDNKDIQDIQDNKDNKDNKDNKDNKDNKDNKDNKDNKDNKDNKDNKDNKDIKDNKDIKDIKDIKDNKDNKDIWQMIEENNFQKLKEIESIPKNQLIKEQKPILHFAIEKQVSKEIIQFLISKGANPNLIDNKGKNSLHIACENGNISLEIIKYLILSGIDINSKTNQNETALHYACSNPNISFEIIKYLISSGIDISSKRDWNSTALHYACSNPNISLKIIKYLISSGINVNSKTNQNEKALHIACSNPNISLKIIKYLISSGIDINSKTNQNQTVLHYACSNPNISLEIIKYLISSGIDINSKTKYNETVLHYACSNPNISLEIIKYLILSGIDINSKTNYGNETALHIACQNPNISLEIIKYLISSGIDINSKTNQNETALHIACSNPNISLEIIKYLISSGIDINSKTNQNETVLHIACSNPNISFEIIKYLISSGIDINSKTNQNQTVLHYVCSNPNISLEIIKYLISSGIDINSKTYYRNETALHIACSNPNISIEIIKYLILSGIDINSKTNQNETVLHIACSNPNISFEIIKYLILSGIDINSKTNQNKTLLHIACSNPNISFEIIKYLILSGIDINSKTNQNETVLHYVCSNPNISFEIIKYLISSGIDINSKTNENETALHIACKNLNPNISIEIIKYLISSGIDINSKTKDKNKTALHIACSNPNISIEIIKYLISSGIDINSKTYYGNETALHISCLNPNISFEIIKYLILSGIDINSKTNQNKTVLHIACSNPNISFEIIKYLISLGININSKTKYNETALHYVCSNPNISFENIKYLILSGIDINSKTNQNETALHIACLNPNISLEIIKYLISSGIDINSKTNQNETALHIACLNPNISLEIIKYLILLGIDINSKTNQNQTALHIACLNPNISLEIIKYLISSGIDINSKTNKNQTALHISCENKNISLKIIKYLISSGIDINSKTKYRNETALHYACENKNIQFIKLLMKNDANIFDLNYDQINEEIINLFPKIYSINEDLNNFLKSSQNENENEKFTDLEIKTSDYFKFKVHKIILLTRFENDKLILQKFINICNRKPKRDVQLALNFLYTGFTNFDYFIQRFQNFINYKNQMKKIDESNQYQYQEENENKFEYEYEYGYGYENKFENENEIEEQENELMKDFFEQIGIESNWIESKKGRKGIIKDLSKLYQQNETKDFKIICSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L513</accession>
    <name>A0A9Q0L513_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L513"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="143" mass="15915" checksum="9AB0FE712E1BA6FC" modified="2023-09-13" version="1">MRTSEVLPIWIVNSIIIIIIIAPSLGVASKDKDKDCSKPLWTWVLVFNICLGVTILFPIFLLNRNFYVIMNFLNGLISLFLIVWSIIGLVWATREGVKDECGKLYSVTLGESIVIISLAGCGCLLLCLFGICWECGLKDINFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5Z1</accession>
    <name>A0A9Q0L5Z1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fch and double sh3 domains protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
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                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9204160at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="180"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="378"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="468"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="695"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="785"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="901"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1282"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1468"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1601"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1677"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="2075"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="2181"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="2257"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="2486"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="2562"/>
            <end position="2621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2344"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2842"/>
            <end position="2920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2666"/>
            <end position="2795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2344"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2443"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2842"/>
            <end position="2858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2864"/>
            <end position="2888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2891"/>
            <end position="2912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2920" mass="345255" checksum="EDB0B02326C1D7D7" modified="2023-09-13" version="1">MSILETQINKISPTTKLLRNKINKLRSELKAVKKIEQMYQNNKEQLARVILEKKQAQLKLSTLKPIYFQANKLLLSLHDQGQIIQETVISPKVTLKPQEKVVIIEKKPNNYVVKLLDQSNHSKIPVPISFIAVQKAKPLDDQYFNSKFLEIMNLISDFDLTDFESKVKDDGKKKKLQLNNNLEKVLILFDFIAESSNEVTVNQGDVVYFKQRTGDWAIIQKDAQEGLVPFDYLQFEKSQNISDNNQQSVIQVELEQYKLLFSFIAETEEELNANEGEIVYKIKDMEEWTLVRNQEGKEGIVPTDYIQKIEIQENKEVKVKLEQYKLLFSFIAEAKEELNANEGEIVYKVEDMGEWTLVKNKEGKQGIVPTEYIQKIINEKDKYQLLYTFIAENPEELNVNEGEIVYKVEDMGEWTLVRNQEGKEGIVPTDYIQKIEIKEIQEIKEVEEKPKEIIKEKPKDIIQTKIEVKEEQYKLLYTFIAEAKEELNANEGEIVYKVEDMGEWALVRNEEGKQGIVPTDYIQKIEIQELPPKPKDIIKEKPKDIIKEKPKDIIKEKPKEIIKEKPKEIIKEKPKEIIKEKPKEIVKEKPKDIIEEKPKEIIEEKPEEIIEEKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIIEEKPKDIIETKIEVKEEQYKLLFSFIAESEEELNANEGEIVYKIEDQEEWTLVRNQEGKEGIVPTDYIQKIEIKEIQEIKEVEEKPKEIIKEKPKDIIQTKIEVKEEQYKLLYTFIAEAKEELNANEGEIVYKVKDMGEWALVRNQEGKEGIVPTDYIQKIEIQELPPKPKEIIKEKPKEIIKEKPKEIIKEKPKDIIEEKPKEIIEEKPKDIIETKIEVKEEQYKLLFSFIAESEEELNANEGEIVYKIEDQEEWTLVRNQEGKEGIVPTDYIQKIEIKEIQEVEEKPKEIIEEKPKEIIEEKPKEIIEEKPKDIIKEKPKDIIEEKPKDIIETKIEVKEEQYKLLFSFIAESEEELNANEGEIVYKIEDQEEWTLVRNKEGKQGIVPTDYIQKIEIKEIQEVEEKPKEIIEEKPKEIIKEKPKEIIEEKPKEIIEEKPKEIIKEKPKDIIEEKPKDIIETKIEVKEEQYKLLFSFIAESEEELNVNEGEIVYKIEDQEEWTLVRNQEGKEGIVPTDYIQKIEIQEIQEVEEKPKDIIEEKPKEIIEEKPKEIIKEKPKEIIEEKPKEVIKEKPKEIIEEKPKEIIEEKPKDIIETKIEVKEEQYKLLYSFIAENPEELNANEGEIVYKIKDMEEWTLVRNKEGKQGIVPTDYIQKIEIQEIQEVEEKPKEIIEEKPKDIIQEVEEKPKEIIKEKPKEIIEEKPKDIIEEKPKEIIEEKPKEIIQEKPKEIIKEKPKDIIEEKPKEIIEEKPKDIIKEKPKDIIEEKPKDIIKEKSKDIIETKIEVKEEQYKLLYSFIAESEEELNANEGEIVYKIKDMEEWTLVRNQEGKQGIVPTDYIQKIEIQEIEEKPKEIIETKIRLNANEGEIVYKIKDMEEWTLVRNQEGKQGIVPTDYIQKIEIQEIEEKPKEIIETKIEVKEEQYKLLFSFIAENPEELNANEGEIVYKIEDQEEWTLVRNQEGKQGIVPTDYIQKIEIQEIEEKPKDIIETKIEVKEEQYKLLFSFIAENPEELNANEGEIVYKIEDQEEWTLVRNKEGKEGIVPTDYIQKIEIKEIQEKPKDIIEPKNKEGKEGIVPTDYIQKIEIKEIQEVEEKPKDIIEEKPKEIIEEKPKEIIEEKPKEIIKEKPKEIIKEKPKEIIKEKPKEIIKEKPKEIIKEKPKEIVEEKPKEIIEEKPKDIIEEKSKEIVKEKPKDIIEEKPKDIIEEKPKEIIEEKPKDIIQEVEEKPKEIIKEKPKEIIKEKPKDIIEEKPKEIIKEKPKEIVKEKPKEIVKEKPKEIIEEKPKDIIEEKPKEIIEEKPKEIIKEKPKDIIQEVEEKPKEIIKEKPKEIIKEKPKDIIEEKPKEIIKEKPKEIIKEKPKEIIEEKPKEIIEEKPKEIIEEKPKDIIETKIEVKEEQYELLYSFIAENPEELNANEGEIVYKVKDMEEWTLVRNQEGKQGIVPTDYIQKIEIQEIQEVQEKPKDIIEEKSKDIIQEVEEKPKEIIEEKPKDIIETKIEVKEEQYELLYSFIAENPEELNANEGEIVYKIKDMEEWTLVRNKEGKEGIVPTNYIQKIEIQELQEKPKDIIETKIEVKEEQYKLLYSFIAENPEELNVNEGEIVYKIKDMEEWTLVRNQEGKQGIVPTDYIQKIEIKEIKEKPKDIIEEKSKEIIEEKSKEIIEEKPKDIIQEKPKDIIKEKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIQLPPKPKDIIEEKPKEIIEEKSKDIIQEKSKDIIKEKPKDIIETKIEVKEEQYKLLYSFIAENPEELNVNEGEIVYKVEDQGEWTHVKNKEGKEGIVPTNYIQKIEIKEIQEKPKDIIETKIEVKQEQYKLLYSFIAENPEELNVNEGEIVYKVKDMGEWTHVKNQEGKEGIVPTDYIQKIEIPQQTKQLEDNSQILELQEYLQNLINDNQLIQSKKQKVTQLLESKQARELTEKENLEKKIQSLESNIKNRKNQIKKIEELKEKINSKNFEIDTLKKNLENKNKSHLDSVSILKQKINEKKQILQEITQKAQLQKKQEEKKRVRTFFGRDKKVQELKEKIQKLELESSELKEQIQKSKPKTKSLKLEDISITSLTPKSRVQLHEAKNIQEKNRNLKKSIGDLKSNIDKMKKRIESEKSRKPSPRQPQRQPQRQPQRQPQRSPQRQPQRQPQKKQDDDDNERVTHKVPSFDKIRQMFQGGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L664</accession>
    <name>A0A9Q0L664_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L664"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="176" mass="20316" checksum="304C8F875E9A4886" modified="2023-09-13" version="1">MNDCLFFGRNDFVVLDENEPEKITKPIQFKFENENENENEKQIKQISSKNIQKVTVGEENENILTIEGNVFAKGRNINPKIQNEFINISSLIEDTNDRIIEDVVSGNNSIYLLSSNQNAYGIGSNHYDQLGFDYETLEETEKPILMMKNVSKIFSGNTSNHVFLLNSKSRIIWMWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6C0</accession>
    <name>A0A9Q0L6C0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_13206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6C0"/>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_GajA/Old/RecF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease GajA/Old nuclease/RecF-like AAA" evidence="6">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="201"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="614"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="745"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1104" mass="131917" checksum="CE4E697823A3DD7D" modified="2023-09-13" version="1">MSYSKKRKSFSFQFPRGRITQIYMKNFQIFDECTVFPGPKLNFILGPNGSGKSTIINAIALGLGGKPQFLERQDHVRDFIKTGSDLAELEIEVSCGKGRTKLFRRIISKTKPDKYYIDRKRIDATDFVDRVRAFNIHFDNLCQFLPQERVSQFASMTPQQRLKETERVVDKELLEKHSELIKKSGQYRDALFGSDQEQKNYEKIRVRFEYLKKAMERIERQKELMQKIQLLEGKLLWMKSEIAENKIVLVQSNIEKLIRKEKKIMTRYSHLNQNLEKYQKQSQEVEKEIRELEKLISKYNSRMKIIFEKLDSHDLEYQKNIEDIKNVDEDEERNKKQIQKLLKEIEELQKKNIQDTKEQENELSELTKKLKDFRNSSDQLDKEKKKVSKQKDDYFRRKQRNDETIREIENRKRKICDQIYQRFPAAQKAREWIDSHRNRFKHQVFGPIGAEVEFHSKEIATIFETQCFQAINTFVFLCEEDLDFFFQNAYQKEGIKIPLYEWSKKPLVYNNPFDINEIPKNLGEVFFLDQGFDAVDSIKECLIDKCKIEKTLCYRGSSERTEKFLIDNDKVMLFYTSTHKYMKNISRYSSEVSYRTQQIRSTRFYRDWTNYSDVQGLKQQSLELENQIKELDIQFQNIEKQQIDLHRDNEGFRKRKNILDNEIRRIKIENAEIQRSLKNKQKDLKDKQKKNFEILRVELIHNKTQNLQSIEKKNGQILDELRHYSTSLQNSNIKQIQKFLILEEKNKCSREIEEYKSKHEQIFREKTAFERQLKDLQEEFKNFREKAIAKTGEKTQILEEQFAKLPNDINEIERQFHKATSKLNSLESEDADAIIKEYEEKKIELERISENIKNSESIFKQIRQEMEIMEREWIVNMEEIIKKLNVKFEWLFEQFGGGGEIQLIKAQNYEYENYGIDVLVQFHSSKHLQKLTSARQSGGERTVSTALYLIALHRCTQSPFCIIDEINQGMDPDNDKKTFQLLANSVRKESVPQYFVISPKLLPSLLPDDDSVNNIRFHFVFNGVFLPDYNHWIKSKYVKKYSPHLIKQQEQQQEKEKEKEKEKEQESESESEKENENESESESESEKISQSAKRRKRRTRKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6Z5</accession>
    <name>A0A9Q0L6Z5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6Z5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="159" mass="17289" checksum="95348970631E3059" modified="2023-09-13" version="1">MQFIYRRRGSPELQEKAISLAISLCCSIIMVSGFVVPSVVVAAQDKNISCSKNLWSWILVCNIAFAVNSLIGVFAPFLKEGSMGIVQTVNLLLTLFLFAWSIVGIVWATSSGVKDTCGNLYKVALGDSIAIISLYGLICCLACCMIVFFMAAMSNTQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7J5</accession>
    <name>A0A9Q0L7J5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7J5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040370960" evidence="1">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="274" mass="32042" checksum="4B23C3D493C050A7" modified="2023-09-13" version="1">MKNYIIVFLICFFILFQISFTKKKDTISGYKTKDLNQLGKENSETIRYKAIRALIHFDFEEAYDILSNEKKYANIYGVFESAYHTSYFISTNCHKHEKLCKKLTEDGKITFGILEAKWYSSGLIYDQDKNVSEYLKNSSNFTSLNLRAEKEFGDNILFIIAENFFTCSKKSFDEELSKLDKIDQANLLALLAEGYQIFLSFCEKKPDGNVCFECNSLFTPKGALLLARFNLADKQFFYEKELRKRYKQFISLQNSTTNSTRNSTRNENFEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8P4</accession>
    <name>A0A9Q0L8P4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8P4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="590" mass="68973" checksum="3F7A4A2AF35CC1B4" modified="2023-09-13" version="1">MNEILFFGSNQKPILLKNKSNKIIKPIPIKFENENENENENEKQIKQISTGEFSTIFLFENGKAIEYLNENIQKIQIENIQKVTVGYLNEAILTKEGIVFAKGNNINSKNPNEFINISSLIEDTNDRIIQDIVSGRTSIYLLTSNQNVYGIGSNRYGQLGFDSKTLKKRKKKFLMMKNVSKIFSGNSSNYVFLLNSNQELFTCGYNHYGQLGLGESRKKEMYIKKLTKIQNIPKGKIIDIQCGNGYSIMLIENQNQNQNENPKRKFYSCGDYTYNGLGKDENTYEFTEIKSSLFENDDDNILDFSVGNFHNLILTSNNKLIGFGDNYSGELGTGNIENKSTPIQIELPKLRFKEDIFNYHISCGDSRSFLYYYYSSSSFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLKDQNELEKLQEIISKKSIKESNQIFEMIYSNRKINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVINDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIDELEIGIDYFQLNQTNPNLFDLLINKFNDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8S1</accession>
    <name>A0A9Q0L8S1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8S1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="89" mass="10664" checksum="36F7431D321EFE9A" modified="2023-09-13" version="1">MFLLNVNDTSNQVHDYSGKSFETIQELIYFLYHDKIDETKLTKEIFEEFTDVKDFYQLNPKSILGSYLLDFYSKNIFNSSKTKKEEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8V0</accession>
    <name>A0A9Q0L8V0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8V0"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="94" mass="11345" checksum="AA48508D1816D6E8" modified="2023-09-13" version="1">MRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQNYNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L929</accession>
    <name>A0A9Q0L929_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L929"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="612"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="680"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="714"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="748"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="782"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="825"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="859"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="894"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="928"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="962"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1278" mass="149777" checksum="DE915344ED69DD43" modified="2023-09-13" version="1">MFLNVNDSSNQVHDYSGKSFETIQQLIYFLYHDKIDETKLIYEAILKNDLEFFDSIKTLQTTEQLEKENEPFLNYSFKNKSTNEIIKKLIEKQTNLNWIDKNRNNSLHSALINKYPNETIELLIEKGSDINSKNKWNEIPLHIALRYNNPKEIIELLIEKGSDINLKNKWNEIPLHIALRYKNPKEIIKLLIEKGSDINSKNNENEIPLNFALRYKNPKEIIELLISKCSDINLKNNKNEIPLHIALRYKNPKEIIELLISKGSDINSKTQFNHIPLHIALENKYPNEIIELLIDKGSNINSKNNENEIPLHIALKNKNTKEIIELLISKGSDINLKNNENEISLNIALRNEYPKEIIELLISKCSDINSKNNENEIPLHIALKYKYPNEIIELLIEKGSNVNSKNNENEIPLDIALKNKYPKEIIELLISKGSDINSNNNENEISLHFALKNKYPNEIIELFISKDYDINSKNNENEIPLHFALRNKYPKEIIELLIEKGSDINSKNKWNEIPLHIALRNEYPKEIIKLLIEKGSDINSKNNENEIPLHFALRNKYPNEIIKSLIDKGSNINSKTKWNEISLYIALRNQYPKEIIELLINKGSDLNSKNDLNEIPLHIALERKYAKEIIELLIEKGSDLNSKNYQNGIPLYIALRYKNPKEIIELLISKGSDINSKNNLNEIPLHIALRNEYAKEIIELLIEKGSDINSKNNENETPLDIALKNKYSKEIIELLIPKGSDMKSKNDENETLLHFALKNKYSKEIIELLIEKGSDINSKNDENETLLHFALKNNNPKEIIELLIDKEIIELLIDKGSDINSKNKWNEIPLHIALRYKNPKEIIELLISKGSDINSKNKWNEIPLHIVLKYQYPKEIIELLIPKGSDLNLKNNWYKETPLHIALRNQYPKEIIELLISKGSDINSKNNQKEIPLYIALKYQNTKEIIELLIEKGSDINSKNKENEIPLHFALENKYPKEIIKLLIEKGSDINSKNKWNKTPLHITFQNKYPNEIKIMLLRDLNISELKQKQITQEMIDLFPKIYSFNDDLNKFLKSNEFTDIEIQSSDGFKFQVNKQILLIRFDNNKTIFEQFINISQQKSKEIIQFSLNFLYTGFIDFDKFIEKFNNQFIQKEKEKEKVYDLFKEIGFDSNWIKEKEGIKGILKDFHKFYQQEETKDFTIIFDNEKEIKVHKLILTIRSYLFKGMFLNVNDSSNQVHDYSGKSFETIQQLIYFLYYDEFDETKLSKENIQEYVDFKDYYQLNSNSIIDLILEDLQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9H0</accession>
    <name>A0A9Q0L9H0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9H0"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="348"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="520"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="623" mass="72676" checksum="BE2228641DFD9040" modified="2023-09-13" version="1">MNDCLFFGENNYPKFFKNKPNKIIKPIQFKFENENENENENENEDPILIKNEPDKIKKPIQFKFENENENENEKQIKQISIGCFSITFLFKNGKAIEYLPFSNQNPHKIQIEENIQKVTVGSGNEAILTIEGNVFAKGKYINPKNKKNFINISSLIEDTNDRIIQDIVSGANSIYLLTLNQNVYGIGLNDFGQVGSDSETLYKTEKPILMMKNVSKIFSGNSSIHVFLLNPNQELFGCGYNRFGQLGLGESKKETIKIQKLTKIQNIPKGKIIDIQCGYIHSVMLIENENENPKRKLYSCGYYEYNGLGKDEDIYEFTEIKSSLFENDDNILDFSCGNGYTLILTSKSKLIVFGSNELGQLGTGDTKNQLIPIQIELPKLRFNEDIYNYHISCGNYKSFLYYSPFLSPFLSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYYEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQILEYWIYSNQIKDEIQITQEVINEIQIGIDYFQLNETYPNLLDLLTNKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9J1</accession>
    <name>A0A9Q0L9J1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Regulatory protein SIR2 homolog 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">SIR2-like protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_12243</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9J1"/>
    <dbReference type="OMA" id="SNREYCK"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF1">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="13">
        <location>
            <begin position="17"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="275"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5068822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="343" mass="39325" checksum="85BF163A15463D8F" modified="2023-09-13" version="1">MIAGMNDEEIKEHHDTEKEIKQKVSELAKMIKESKHCVIHTGAGISTSAGIPDFRGPNGVWTCRDQKRALPRGKRFKEWRPTYCHMAIVELLNQGLIKHLVSQNVDGLHVRSGIPLEKISELHGNTHKEYCSKCGKEYFRLFETRNAYSVTDHRTGRKCDICGGMLFDSIINFGENLPKNALDKAFKESTKSDLCIVFGSSMRVSPANSLPVIPVKQKKGKLVLVNYQKTPIDKHCTMIIHSATDLVMELLMNELDIKVPDWEEKLTEIIEEQEQELKKKSEEKSKEKPKEKPKEKSKDKSKDKSKDKSKEKPKDKSKEKSKEKPKEKPKEKSKEKSKEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA76</accession>
    <name>A0A9Q0LA76_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_11791</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA76"/>
    <dbReference type="OMA" id="SENAYIC"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="13">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5069306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="201" mass="22970" checksum="F901E496434B1583" modified="2023-09-13" version="1">MEFGIYHEVQKDDALCAAHCLNSLLQGQYFSAGELTEIAETLDELERQTMAQNGIDSVDFLKFMAQDSKNVDLSGNFSVQVLIKALEAFNISLIPLFHPSEKNSRENPHLQNAFIANYMSHWFTIRKFGGSIWFNLNSLFKEPEYVSSTFLSLLLSQLQQEGYTIFVVKGILPESKADQFLEGLTELPNYKKYQKPKQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAZ8</accession>
    <name>A0A9Q0LAZ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAZ8"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="168" mass="20595" checksum="BA3B666B55A0BB0A" modified="2023-09-13" version="1">MNKNLKENENQNRNRYYWGVREFKEEKRILKEIEENENKIKEFFKEIGIEIENKKRRKGIINDLSKLYQQNETKDFIIISEEKEIKVHKLILFTRSELFKGMFLSVSDSSNQVHDYSRKSNESIQQLIYFLYHDKFEKEISEFNSKIIEEVEELKDFYQLNKNSKFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBH1</accession>
    <name>A0A9Q0LBH1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cerebellar degeneration-related antigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBH1"/>
    <dbReference type="OMA" id="TEINTHT"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="234" mass="26646" checksum="1892749816297B47" modified="2023-09-13" version="1">MSSKKNKEKTSEHPLKETEHKEHNGKKEKNKPRNLEQERRRKPTQNQEKEKNDEHNTTTETNQNPNPNTDLKSKSNSNSNSKPNPNTDQNQNQNPNPKSKSKLNSNSKSNSNSKSNSKSKPNSKSKSKSNSKSKSKSNSKSNSKSKSKSNSNSKSNSQEFQINDKGKGNQEKQIKKRIKGDIKKKDNETRKIKINNSTDKDNNQSQVKKDEDNTTTEINTHTNKDDNSQKDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBK3</accession>
    <name>A0A9Q0LBK3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BTB/POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBK3"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="285"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="56438" checksum="D94D82CC5E3CFA46" modified="2023-09-13" version="1">MENYLNLEKLSNDLKNLFQNQNQNENGNYFDFEINCEQNQISFKTHKSILSSRSQYFKSLFKSKMKEYQENKLILKDVSSSILFPILKYLYSGKIEINLENAIEILIFSSKYLIDELIEICLNFIKNNLQIETIVDVLKLSESMNLNELLDYSYKFISENFEKFIKTSFFLELEENHLNSILSKEDISTNEFELFQSIIKWRKHKSNDNQISNIIIEKIRFIDFSKEELENTLKEDLIPNKISEKLIQLQKLQKQNDEKELEQFIEKEKENSLIFQPRFKFDSSMVQEKEQIKKLKEWINDNGFFSKMKKGFSAKRDGFSSYKWHSKCDNKGKTLVIIKTIKNFIFGGFTSVGFTNNKLEWREEDRNTDQGFIYDENAFIFSLRNDTNDRKPEKFSIQKGEEKFAIKYHPIYNPAFGKYGPGKADFCLYSDLNGFYSNFGSVYNLPDGIEYESNEAKSYLAGSYGDWEVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2024-05-29" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBV2</accession>
    <name>A0A9Q0LBV2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1532" mass="182411" checksum="CACA69EEA170A78F" modified="2023-09-13" version="1">MLKGIHKYWLRMAKTRTMIILRNLVFQASNPDDTNVIFVRELCEYYFKEVFSPNFDSWLKSLPNNEDPKSVILLTYSPPFEKGFDKYFKKDTSDIVKLTSFGTSLDFEQKLLSISNTHLKKSKFTLVIQIEAAAQKFVMEQFRHTKHIIERNFRLENQKEYKALIVFMVHIPTNDKLNNFKICFENKWEIFHLDDLDPPHNFDISYYFHPKRTLIDIVNDLSKQLVPINENDDKKQKKRHRKSNTNQDNKMDFFSQILRASFMDISVAYSNFNQQIQHFNTISQNPKLRNLIYSKLKTLVETAPSQNTLYHWKLAIENLEKETKSIGETFESSSSLCFRQISSQLSQITNVLLRQLDQFNNTESYLNPIYESIWITICEKFNPSHTIPTILRTSIQSCKFPFSFYILSLFKSFSEDPLLDMKFKEFSKQKDPEVYSMWINDFLSDLVLLNFSDSQFKIFSETNLQNFEFISSKRNKEEDSEITFRNLYDYYSENSGNLSKMIVLFENWNLRKIDTISLTDKFITQLLSLIEKKLNKIINDPKSNKFQNWIINFRKTEETIKEVLKNYPESEQIYQFINLQLLSFTAEYFYLPYKNQIKSKKDFFQNIQRFKEEIMNKDQKFEFFMLNLKSYASYISKQPFYEILREFSTRKNIFLEMKIDFSSGKSTKKSTKKSNKQTQIVKCTKKSRYILFKDVEKARTCPICKSTIKKNKSHFISLKNEEIKDLKEKNNTFINQFNIFLHNYMKIIINYFTISRKDSIENQSNWSEFVDFLLLLLSKEEEGNVFEDLKFISIKEILLNSFLFNTFENPNLFKDVQNKFKPNFHQSLFPNILYFYHEVLSTNNKYQNKKELEVNSLITFSKEAISKFSDIKKMVEISHFISQFPENFLEKAYSVIEQSQIMKSWIIFSFLQIYKKIGINYLLQVLKKNKEQNKLLIDTFSDKNETLFNEKHFTLQQKIFLISFIDRPNEITKSTIEKKDQKDLETINKINSKIITNYLQVIVDNKTDFPNKEVSKLIKSNSSIENLFKILQKQLLLDNNFGSKTQKIMIIQILEYVYLKKWEPFYSILLLSDSIQKKGTKSKLGNILNKNEFWPGIESSIHQEMIGEITKFQISHAYTIRELNPISLCLCRIILFSCLLTRLITSNSSIVSLFIPENKLKNINLDDEKIHFKEIIQNRIDEEFEIISTQLNISKEYAIYYVRLFFYRLKMENEERKLDFDFMKKQKGKERQRQKEIQKENRDNFEKIISILQNEYHSKIMNTLKEIKEKENKILESLIPLEVLPNKLDLSFDNTSNQFNDFRNQTQFPLVKIYLNHQEEFSIFTSFPGFLFFSNQIISLNINKDKPIGFHYLYQSLKIQPNINSDILSKSFEDFQVIWNYISNKISKRFFTNSFTDVIFPEITEEKVDIGKQKDVINFIYGIIKYIVRFNNTIIDEIFQEKKEEIQFNDILLNFPLPEDLSKNIENISSVFHLDYSEIYFFISKNKINLSNVEIFEKFLESKISSFSSTLTKIDADSLDPSLDPFQKINKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC40</accession>
    <name>A0A9Q0LC40_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC40"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="488" mass="57993" checksum="93512646D1DB2CBF" modified="2023-09-13" version="1">MSNGYISPNEQSSQESLSSDDSNRKHPHNRNTNEDFHETKKNSPMTLQQAFEKIMEIKVQYNKNQISKQDYQKILSEIPPNLFEQIKQLAQKTKSKQLNQHQNQKQQDQQQNYRKQNQIVGNYKERPIFLDLQALSRVIKRFTDHHKLKISEDFDKILLLISKSTEKYMTKTLQELVQNSYFRMNVPRNYFNINESRSAKEILNEISNQNDKEQLEAEKIKEEKEQQETSLKNQYNNPNQTFKEANIIVSGLIGDRPLKKGKRSKKLDENQNKLSFFIEQNSKILEEGNNYSIVEMHDARSRLIEKMQGNNQLYIDLVNTRIHHLQNLLLAYKTVLSDPNSIPNFDIPDLNKKLVSLNKQLEWNKLNLDQIQREAPSESSQEMFRAAQNLKLFELRELIEVYEKPIRGNRSLLTPIDPRFSDDDIFPSRKLLDFERKKELDPKNQMNPFSYQIYPRVITFKDIFNFLENHPNRFKQLFWKKIVARQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCV9</accession>
    <name>A0A9Q0LCV9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCV9"/>
    <dbReference type="OrthoDB" id="7972088at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="301" mass="35674" checksum="ADA01DBBC8ADF287" modified="2023-09-13" version="1">MNETIYSLKSLYDLSKSQLEQLLVKEFFAYQELINQISKNQPDFKLFCGKNKIQIDCHEFVLRLRAPFLFLQDDINENKQFDFTEFEVETVDLIVKFIYTGTIEFEKESFEKIWKLANQIGLKTLKIKMEKEIQEIIDKSNAIKYYLLTKNIGSIFLYRFCESIIIENLEELFNQNAFSKLNQEEIIQIISMIESRIKGRNKIQIILKIIEDWGKTIDEKQENSELSQVNIDSDNSQQNNSENIFSRKILFDTIHQIQEMKQVSKTQFETIQDHSFLPLGIIRKFNGNENEENARRANNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD91</accession>
    <name>A0A9Q0LD91_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD91"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="190" mass="21333" checksum="AD085D06C3AB7350" modified="2023-09-13" version="1">MTLVLIIGDIFIPNRAKQIPEKFTKLFTPGKIQTTLCTGNLTDPKILEYFETITPKNVFCVAGDSDDEKLQFPEFYQTKIGGYKIGMIHGHQFITEDKTNLQELITENNLDILIKGNTHKLNTEIFEETLLIDPGSITGAQTLMNSNIKPSFSLLAFGFGGKYPVVYNYIISDDELTVSKFDSNLKAKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDA4</accession>
    <name>A0A9Q0LDA4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDA4"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="482"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="828"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="936" mass="108955" checksum="2AAFBACF07C8EDE5" modified="2023-09-13" version="1">MNFWKAIQENNLEFLKQIESIPKKILIKKTKPILHFAIENKASIQTIQFLIEKGADPNINDKFGRNSLHFAIINNSEFEIINFLIEKKASIDIRDYEQKTVIESALIHLKREDSLQTIKLLVEKGADIHSICKFSDKTLLHLACQNNKFKALEIIKFLVEKGVQINYQEEHFYQSPLHFVCRYQNTEYAFDIIKFLVEKGARINSTTKRNETPLLLVCQYNTQKNLIQIIKFLVENEADINARNDEKESVLHIICKYNPSIEIIQYLISNDVDINSKTKEKYSALHFICCEKNPSLEIIRYLVENGIYINAKTIWNQSVLDFAFPSKSNQVIKYLIEKGVDILSKTEKNETTLHLACQNNCSLEIIKLIVARGVDINESSKNETALHLACKNNSLEIVQFLIENGIEINAKANFDLETSLHIACSTKNSFQIVKYLVEKGADIDAKDFLDATPLHYACEANSFEVIKYLIEKGADLNAITKRRKTALHFACKNHSMETIKYLVENGIDMQSKSNEDQLLLHFCCIIHSPYEIIQYLIENGIDINGKSSEKETALHHACKNYNSMEVINLLVEKGIDINAKNEENETALHYACKINSLECIQYLIDKGIDLNAKNNNQENALSFAIQKEKVDLIKLLLMNNANIFDLGDAITNDFFQLFLKISSLNDDLNNLLNSNDNFPDYQIQSNDGFKFQAHKMILLSRFNNNTSILKKFIQKCQEKPKEDVEILLNFLYTGFCDLKKLKEYQQKIIERKQKRMRIFSFDDNESIQQNQQNEDEEKKLSELAQKQYQTIQDFFKEIGFDSKWVESKEGRKGIIKDFQKLYQQEETKDFTIICSNEKEVKIHKLILIIRSDLFKGMFQLNVQDSSNKVHDYSGKSFETIQQLIYFFYHDEFDKKNEILKQKIEEYEDLKDFYQLNENSIIDLFLFELQEKLKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDJ2</accession>
    <name>A0A9Q0LDJ2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2059 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDJ2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018637">
        <property type="entry name" value="DUF2059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09832">
        <property type="entry name" value="DUF2059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2059" evidence="1">
        <location>
            <begin position="55"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="139" mass="15913" checksum="D8ADE7E7A46A3325" modified="2023-09-13" version="1">MSEQKLADIRKLLELMNSAELGKSVFVSVIQNFRQMYDDVPSEFWDEVEKEVNYDRLIELIIPVYDKNLSHEVIKSAIEFYETKNGQELVKALPQISQESMAVGNTWGMELGQLVVEKLSLYQGDDDGDDDGDDDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDU0</accession>
    <name>A0A9Q0LDU0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear pore membrane glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_01874</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP210 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HNMYEGT"/>
    <dbReference type="OrthoDB" id="16413at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1080">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058779">
        <property type="entry name" value="Ig_NUP210_13th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057586">
        <property type="entry name" value="Ig_NUP210_16th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055099">
        <property type="entry name" value="Ig_NUP210_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056899">
        <property type="entry name" value="Ig_NUP210_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055094">
        <property type="entry name" value="NUP210_Ig15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26181">
        <property type="entry name" value="Ig_NUP210_13th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22959">
        <property type="entry name" value="Ig_NUP210_15th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25354">
        <property type="entry name" value="Ig_NUP210_16th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26182">
        <property type="entry name" value="Ig_NUP210_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22962">
        <property type="entry name" value="Ig_NUP210_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24902">
        <property type="entry name" value="Ig_NUP210_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040509645" evidence="11">
        <location>
            <begin position="25"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1881"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="12">
        <location>
            <begin position="251"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="12">
        <location>
            <begin position="459"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="12">
        <location>
            <begin position="1520"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1923"/>
            <end position="1945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5070893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1971" mass="221530" checksum="682348101B068813" modified="2023-09-13" version="1">MTEKKIILLIVVLFLIENLYETKTETETTQIGISEINLLLPFHPKIPISYKIHAQNGCFKWSSSRPSVVNVETLFENSLDCSQSAIITATSKSSDRTSAMIYAEEKVSGQVLRCEVFVDKITKIEILTRSRTIYVDSSIELLEVQGYDSEGNVFSSLSGISFDWEINSKGKNILSKISVEKAFLMKPFVKEYEETKEWLEDKGSENTNILLVQGISTGKADVTASIKDDIYRDIEKSTVTISVMEPIQIQPFQNVYLIPKQQFQYNLILSKREKQELIKMPNTNYKWRTTNPEIATIDQRGMLTAKSYGSTEILVTDQNIAENEARATVYVVKPEKIKLAIHDVPQEMSTNSLEEKMKYLSIPNFQSSYWENSYWALFINNEHILEIELIDKDLHKIWINKNTGSFSIKFSDPKILTIVEESKKHETVNFKTKNYGETTATAIFKSGDINLSTEEKITVTKQISVNPSPVLRLAFWENLAIPHTYKLDVSGGSGSFVFKTDMSQIASVNAIGMVSGIKPGESKLKVSDQKNPKNYEIITVVVEKPSSIQIVAPFNEIEVGKLLELEIQAYDSKHNKFHNSSLLPIQWKMSNMENFELKKHKQMEQILTKQGVLAHHEGFSTITASLLGNGFEEQINAHIQIAGFFPLEVKHFPNKYCESKNLALTTLGCSATVLITGGPLPWGDSPEFIQEILPQIPDSVMVSNSERVGVTQQKIPNQSSRKQLISISCIDYSKQQIAVKVRNTPSKTNPNPITAEIDFAYECNPPEKIFVFPMQIEDELKSQNYLIKDPENQAHKCPYDLQNFPKHNKINLQTNIPKQYQMRNEQKVKIVALFADSQGRIFEEFDSLMVSFVSENPLANFENLKEKKNKAELDMEEYETRYAKEDVITLGKEIGTAKINVKTTGFGGENKALIKNTKEWTSKLSLEDNMRIILVSKIQLFPKKIVLFNNETSTGILDVVPKTTTYDITSNDSSIAHLKQISNKGSVEVIPKSRGVARVFINDYCLQGSVPAYADVVVSEISKIALFSQSKLQLGDKMKVRVEIYDDLGNKFPVKQMKFINLIAIFDRDVLSSMNEISEQVSKAIEKDGDATSFDLEFKGISLGLGKIHLQAKLRNGDLTESNTRKVVIFPPLMLNPRFLLLLPDSEHQLTKTGGPQLYSEIRFRSEDPNIASVDKHGIVKGIKEGKTKITAEILENPNEISESEIVLSRDQIDVSVQILKGIRIQAESSLLLTGNERTYHVSGITNENVFSFSSLKHLGDYLRFDWEVSNKDVLEISALCGQDSGFSVLAKGKNTGTSILRVTAKSKTNKKSNELSDETTINVIDRLTLLSPQVVYLPPRSGAKIETNWDLREPLQYRVMKTSSGEKENQESKDDLISVDLSGKVYSKDRYGIGYVVVEPKQSDIPTRRAAPEKLDSLAVQIVVKPVSSLSLIPIDACYSVLPLGASLTYKAILKDSLGNSFTSSDGIKFNYEGTNPTSISVQHFPGNSTFLVKALNDGSSVLKVWLRGQPEISDFVKIQAGGTIFPHNPNVHIGAQIKFHSPDSFSSLEIKSGSENYDPKNFAKWISSDPKIVEIDEKTGIATAKNSGKASIFYTTQKIRASTEIVVAKADSITVNTDSLGVSSILGEPNTILIGSTQKEYKIPLIFTHENAPFSPSSSFLQHNFRHTCEIGNPQYGTAQAMNDPHNSQAYCLLTIFSSHKIAEKIKTNPNPELSRQTNLKLLITVSDSDQSYALKHFHTINLNLGIMLFYNPNDLHFSKNHRSATVIVYSDADHLDFSSEDPSQIRIYKVRFDEKEYEGVLLANEGGESIFPQVFHIQLTDEPKFFTQSKVIFKDTKTNQVEILTFSFLSDSNYIPNNYDQPRQLPPSQAERQQSKSLFVLVSSLLLAVIVVGVYLFRSYQQNLEIERIRRFRQFSPISPRRSPPNLLRNKHIPPIQTGQNYQSARNKIVPAQITSGIVRRHSKTGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDU4</accession>
    <name>A0A9Q0LDU4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Atp synthase coupling factor b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDU4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="827" mass="96825" checksum="1B80FF42926181E4" modified="2023-09-13" version="1">MSLNFKKQIQSNFPKSENYKILQETFEKKSKLIYQKFEYEKLLKPKYKELIIKIDSLFKPEEEEEENKNNNNNNNKINKKSKQKSKHLQVAIQRFLHRITNFVLIPFIQNYLMKEWFDIQFKEVSRYFSDYERNSHKIPKFIGSLNTSSCYPKLWNSNLIGAAVKFLEDISTEIINFGSFDFINKQKLKEFQFKLSNFLIGKEKEKEEKKEKKEKKEKKENQTKIKSLEEISRKVIENTSFVFENELVKNLPLNILEDIFDEMNLNGTITSSNISNFKQFEALDFKGNFWINDNTVSKLIHFDNLFELNFTGCLGLTNESLKIICENEMIQKNLEVLILGVWNGKPLLTHEIDCKLGLIDDRDFISYPEPSFFLKISEDALINLKYLKNLIYLDISGCLGKNNPNRDYIYNDNYGENYQEEIFQEFLPQLDKLQTLILGNGGVTTSIVEMIPSSIINLKIKISGASKIIDGEYHNNLIPIYNEVRKVKRSKMISAFEKLVNLKTLSISEMQLINYSTRIFDKPDENGYLLDNKFGSLLKNWNQLTYLKIEPFGYIDDFEIVRDWIPNFSSQLLSLDLSGNKWIADDILLELEKESKGISRLTLLRSLDLSNTFVSDESLCKILPNLIQLNYLNIYSTRVGNETIKCINQYLSNLTILKLRGWNYSNQITNITNEGIYELALNQNIQKLLLTSFTNDITILTECNCSKSYKENEKCIFSLPLWKNVQELYLNKMEIDGLFKHLESTNDPTFLQNLIHFEWQTIGRPHIGRGNYFFIDKIDYYYYRDNGYEPILKKLKNLKSFVGSEYIGNGDGSVLFCDCPNHIPQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEB8</accession>
    <name>A0A9Q0LEB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEB8"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="265"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="486"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="69898" checksum="1BBA4EC32EC03124" modified="2023-09-13" version="1">MNDCLFFGQNELPRIIAFEPEKITRPIKFKFTSENQNAEDLEKQINQIKQISSSSFSTVFLFKNGKAIDYRRRVNTQKIQIENIQKMTICNWNEAILTIEGNLFAKGYYVNPSNRKKMINISSLIEDTNDRIIQDIVSCVKSVYLLTSNQNAYGIGSNSFGQLGFDSKTLEKTQKPILMMKNVSKIFSGNTSFHVFLLNSNQELFGCGYNEFGQLGLGESRNETEINKLTKIQNIPKGKIIDIQCGYFYSIMLIENENENENPKRKLYSCGKCQYNGLGKYDDSYEFTEIKSSLFENDNILDFSVGGSHTLILTIKGKLIGFGRNEYGQLGTGDTNDKPIPIQIELPELRFNGDISNYHVSCGDQKSFLYYSPSSFSNLEEDLIKLFRRKQFCNISFKIENGEIIEAHKLILKYRLNQDQNQIEKLQEIISNKSIQESNQIFEMIYSNNSKINPILYSEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYREMFLSVKNDTSNKVTDYSELSNKSFQIIEYWIYSNQIKDEIQITQEIIDEIKIGIEYFKLNQTNPNLFDLLNGQFNNQNLQKKGNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEK3</accession>
    <name>A0A9Q0LEK3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEK3"/>
    <dbReference type="OMA" id="FASEYGC"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="185" mass="20740" checksum="0B42DEACD729FBA1" modified="2023-09-13" version="1">MNQQTFRVVVIGGGSVGKSCLTTQFIHGKFSTDYDPTIETHLEIIDTAGQEEYRSIRDRYLGLGDGFLVVYSIISRSSFDDAKNLHQAIKRTRTGNKAIALTVANKSDLDTERVVSRELGQELAKDFGSIYYETSAKTGSNVVECFHCLIRELRKSKKPEDSNNKKFDDDDLSEKEKTGKCCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGY6</accession>
    <name>A0A9Q0LGY6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGY6"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="181"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="294"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="575" mass="66793" checksum="D83EABA4630BF2F9" modified="2023-09-13" version="1">MKIENLIENKNLFQFENENENEKQIKQISTGSFGIIFLFENGKAIEYSGLLFQTWKNIQIENIQKVIICYQNVAILTKEGNVFAKGIDINLDNPNEFINISSLIKYTNDRIIEDIVSGRNSIYLLTSNQNLYGIADNHFAQLAFNSEALPTTEKPILMMKNVSKIFSGNSSNHVFLLNLNQELFGCGNNKEGQLGLGESRRDEAKIQKLIKIQNIPKGKIIDIQCGDSHSIMLIEDQNQKRKLYSCGFYGYNGLGKRLQNTYEFTEIKSSLFENDYILDFSVGDRHTLILTFKGKLIGFGSNSSGQLGIGNTEDKSIPNQISLPNNELIPIQIPGLRFKEDIFNYHLYCGNSRSFLYYIPSFSNLEEDLIKLFRRKEFCDISFKTKDGEIIEAHKLILETIIGQDENQFEKLQEIISNKSIKESNQIFEMIYSNNPKINPKLYSEIEIEFNLFNTIEESMKELFENENEKDFIIERKEKQYKFPKLMLMMRSELYLGMFLSVTDDKSNKFTDYSELSDKSFQIFEYWIYSNQIKEGIQITKEIIYEIETGMDYLQLNQTYPNLLDLLIFKFNIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHG1</accession>
    <name>A0A9Q0LHG1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Drebrin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHG1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1135" mass="132134" checksum="7B2D668983EE6B63" modified="2023-09-13" version="1">MTSPEQKEKIYEWLEEIIGEEVNKTTNEKDFAIILASLANQLITKQIPDNKIEKNSPTKNIQFFFTTCKKFGVQPKYLKDKKRGGLLNAVFQLSLIIKKWEKTSMKKSRKLPVSILDGHLKLLSSSELFIESEEIFLLTPSELMQFSCSDIAKIARHPKHKTTVRLTFTDKRAIVIKFVTQLHTNSFIKRINAYRHKDKESGNESENSEKTSKNNQKSQEKDPNSEKSDFVTDTENETQSENENENQNQNQNQNEKEKEKETENDKVEKSSKKKNSQQAKKPTKKNPKAKTNPKTTNKKKKKESSEDEDENNITECSLFSPQKKSKKPTKRLFNVTVTNRSRKNLYPAILHFQKEKFRIKTPTKRFFVKYNTDFRIAFEKTTQRYAKISTPQIKELIVRFVSKKEFRLFSEMYLYLKKNFENPSDDEEKEKEEEKEKENENEKENETETETETENENQNQSETENSQNEENKNSEQNQDQEVMKQSNVQNIQQTPEPNQETPKPNGETNPNSELDEENISREFESEAPSDLESLQESELSSDAQDSDEKNVFDSEAESQDEIEEPLRNSYSQNQIQVQKPRFTSQKSNDFSQLLRKNSNTNDIFIDPKELDQFYQVINTYNGKIVNKNLEVLSPVTLIVTQYHVILRTHEFHQQQLLSLDISSGTHSNHRNIVKIKTPDFSSSFIAFSSVDDALSFKNSFKQSKTNCQNLQINEPIQEDQEYYPKKEGYEMDERNTNKLTQKSRSMQAIPTRTNDDKEEKENQMMKKNQNTLTRSQTLIVNPQVNNMLNEDQQNQNTLTRSQTLIVNPQVNNMFNKDQQNPNPNIQNPNQNPNPNIQNPNQNPNPNIQNPNQNPNPNIQNPNQNIQNQNQNPNQNQNQIIQNQNQNQNQNQNQNIKNIERDNQINNQETPKPPISENPGERIPCEIVIRKPVKRRESGEVFIDDYTISLKSVSTSITANFENRIKMASHPKDKTLLRVNFPNHDAIILAFQSDQVRRKVLSLVSHGRKLFKKTGVKNPISTNNSQQSNPKTENQNSQVSKVDHFYVDIVSKQFVKQNAAELIFYKDFFNLVISSQAPITADYSRKQLSVFVHPKFKKIARLQCLGTSYLMEFTTEERKIQFLEKLKDKKKEKGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHN4</accession>
    <name>A0A9Q0LHN4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHN4"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="395"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="516" mass="61665" checksum="9B0E52C4507FD63D" modified="2023-09-13" version="1">MNKNEIQQLKLNRKLILACQENSIENVKLLIENGSNIHFKAAKGKNPLHFACQNQKQNSFEIIKYLISKKADVNAQTNKGEETPLHFAIQFQKNKENSFQIIKYLIENGADVNVKNKRKETPLHFAIQYQSQNKENSFEIIKYLIDKGSDVNAKNITNKTPLYLLFQYKNENAFEIIKYCVEKYPNLNFENETRKLLVPVCKFQNQNSIKIVKYLIEKGFDINAKIGFYETPLYLALQNRNLKLIQLLMMNDVNIYDLSQFEIIQGVHEIFKFNQMILSNFKFIKQFLLLRFDNDETILQKFIDICSQKSKEYVQIALNFLYTGFTNFDDLMNIFHIITDLQEKFKKNKPNKKNDKVFWHRYYKLELVQNWIEIKKGRKGIIKDLSKLYKENETKDFKIIFDNEKEIKVHKLILIIRSELFKGMFQLNVEDKSNQVHDYSGKSFQTIYQLIHFIYHDKFSKNIKKEKEIILEEYFDLKDYYQLNQNSIIDLFLKERKLKLNFQKIIFSFSKIIKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHW5</accession>
    <name>A0A9Q0LHW5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Aldehyde oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_09913</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="14">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="14">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="PHPTQER"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="15">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="16">
        <location>
            <begin position="244"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="1281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="272"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
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        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
    </feature>
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        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="777"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="808"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="812"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="890"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="922"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="924"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1021"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1090"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5071753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1332" mass="148366" checksum="A6043719FD2B56F1" modified="2023-09-13" version="1">MLKAIPFKVQKKHILTSTRLPIIRAFSQGLKLEKEYEKNQTFYLNGKKVIIDKESADPTKTLLDYLREKGLTGTKYGCGEGGCGACTVMISYYDSQENQIKNRAVNSCLVPLPFVNQMSVTTVEGLGTTKNLHPVQERIAKFHGSQCGFCTPGFVMSLQSTIQSHITEKNGQLPTKKLLENSFDGNLCRCTGYRPILDAAKSFGIDFDIKDSPVPFDKMKKFDPKKHLIEFPEELKQKPKPFVSKSEKHTWYQPTELKDLLNIKAEYPEAKIIVGNSEVGVETRMKNLEYKVSISTSKIPELRQFSELEKGIRIGASLPITDIMDKLEMIIKQKKGEKFKTQGLKEMIKIFDIFASRQIRNTACLGGNIATASPLSEGNPLLIALNAKFGLINTKGKKREVFAKDFFLKKYRQVDIKPNEILVYIDVPFTKKNEIFRAFKQSRRKEEDICIVNGMFRMEVDPNTNKIKDSCFAYGGVAPYTVHAEKTSEEINGMVFNRNAIDKIINKISNEITIRDNSPGGMVDYRRALIKTLFYKFALSVLYEMDPKSVSKGELSTIIEEEKPEMNAKQKFDIMEDMFPITEPQVHKSAELQTTGEAQYTADFAVPNCLHAAFVTSIKPHAKILSINSSQAEQIPGFVSFVSAKDIPKQGFNGIGTVFPDEEEVFATKEVNCVGAILGLVVAETPEIARKAARKISVEYQDLPTTLSIDEAIEKESFYPWCHKINRGNIEDGFLKSDFVDEGEITSGGQDHFYLETHAAIAIPKEEDEIEVISSTQNPAHTQHNISVVLGIPSHKIVSRVKRLGGGFGGKESRACLFATCIAVAAKKLNRPVRFSFERPEDMQISGGRHPFKAKFKVGYTKDGKIQAIDTQLFASMGHSLDLSSAIADRALFHSDSAYFIPNMRVVAKLCKTDLPSNTAFRGFGGPQGIFATETIMDLVARKLKKHPEEIREINLIKDGQKTIFGQDVNDCKAIECWKYITKSKDFLEQKRKEINLFNANNKYKKRGYAIMPLKFGISFTASFLNQAGALVHIYKDGSVLVSHCGIEMGQGVYTKITQVAAKELGVPVEKVFVNETCTSRVPNGSATAASTGADLNGFAVAKACQTLRKRLQPYFDKNPKLKFEEIAHKAYFDQVSLSTTGFYATPDIGYDFEKGKGRAFHYFTYGAAMTEVEIDTLTGGHEIIRTDIITDVGRSLNSAIDIGQVEGAFIQGAGWLTMEEVVIGDKNPNNKWIKDGFIFSIGPGNYKIPSPTDIPRTFNVTLLSNSSCPSNVHSSKAVGEPPFILGNSVFFAIKNAIYAARSENGFNEYFRLDAPSTCAKIKMACADKFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI44</accession>
    <name>A0A9Q0LI44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI44"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="467"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="583" mass="67063" checksum="27FD4753BBC5FFF1" modified="2023-09-13" version="1">METISFLYACGMNQNGQLTLEDKSNIKYPEKVTKFEGKKVIRIAAGYQNALFLLSDNEIEQFGLITTTHTQFFSDKSPIKDIKSGQDHFIALTENGEVYHWKAVNSQSYFSDSLITTNPTLIVFDKPAQEIIGGGHSTYFLTENGDLYGVGSNSQNQISKSSESVITKPELIDNNVERAFSGPYSHQIFFIKEGKLYCRGYNQYGQLGTGNSENKSTNYHLKFFDNQEIIDVSCGYCHTLVLIREGEGQKLYTTGYFDYNGLNKPSNSTEFSLLFNYANQEIIQMSSGSQFSIILVENNNFIVFGYNDWGQLGTKDTANYPQPKKLSFSEFPKEIEIEVICGSYCTFFLQATEKFQSIRQDMFEFLQKNELCDTTIKSIDGHNISFHSLIVTLRTKKLLYEIITILETKTKDEIMSILVFLYSLRIINYSAIQVFCQEIEYPDLIGKNSSNQYNEDFADLYEEMSTKDFTIISGEKEIRAHKMILAARSELFHGMFMSVNDDSGKVHDYRGSTPVLLEKLIKFFYTDKLEEPITQDMIQELTEMGDFYQLNTNSKFFNEVSRFSQKKIITKETKSKKKRFWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKK2</accession>
    <name>A0A9Q0LKK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKK2"/>
    <dbReference type="OrthoDB" id="6138721at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="304" mass="35589" checksum="50BC3C0D844E8DF8" modified="2023-09-13" version="1">MNAADICAIIGSIFGILGSILIIILFVYFGEGKLFYKKLILILSIYDLSQSISYILPGKTDSLVCSIQMYLIGITGLTSQYWSCSISIISYLKVVKDRNDKYLEKLYKSLHLLMWILVFFCIVIIAVFGSPTHSDTYWCWCKQKGITGMMYFFYWTFLVLCLIFYILTVARLKRNFQKIMKSDSKIPKETQMTQLRIQLRMTMIPLIYIILLIPSTIKRVHEFIIENPNDWISVDVLQSIFITTHGFWDFLIFIVFNEEMRKKISESCFGSSNNLEFYQISDFDTIKDFVYSDDEDSRLKEFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKW8</accession>
    <name>A0A9Q0LKW8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="QCEKMRE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="302"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="630"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="778"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1349"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1456" mass="172811" checksum="8DCA087DFA5AF9CA" modified="2023-09-13" version="1">MSSQKNNQKILRKPRKSIKDLSQTNKSNTPNNKQQQNIDKKQSKTTGQRSKKLVKKNPIQNQNKSKSQTKPKPKSTIQNKIPLLKNVLKISSFSKILKDILLLKDLPNLSTISLNDNPIFKLDHYKDFIIFHLPNLQELDGEKINEEARKKANERFKQEEISNLEEELKNAKSEILKLKKENASLEQNLLQTQNELNSTKQNYQEASQQRDRYKEQNETKSRLLAKKTQELTQTTELLFSVQQELAFYKIDQSFQGDWNEFGGQFTWKQLSDGPNTVFTHQPKQTENLNYKKPQEHKPLEIIENNQNQIQQLQSQQQILNSKKKELENGIKEFQNLIIEKQMDSNPQAQKNLELEKDLTKLKDQIEEKKNRLNYLDEQTNPELQKDDSKTKMAKLKLEKIKIKKELKSMESNFQKLEQEKASLIDSKDQVKEKKQHIKLNDMDLEKLKPVVSNIMESKQLEELGNQNPQLILEHLQNELDKVQQQEQNIQEAMILLQKEKQFSQLEKQQTEAETKKQRSLIDSNQSELQKENQDQTDKLQKESSEKSKQNQIQQQMMEMVRVIREKDTLIIEKNKQIQELIEKQGILENQNESLIQQSKLVDSKQQETKILIDKSTTTETKYLLLPENKQKQQEKATSELTQKIKDLESENKRIKQDLDNYTSNLQKTGKDQDPNQKQLMSFQSKNLQLETENKKFIQEKMELNQKVISIENQLNLDHSSPLSLLEVLKDEIISQQSEIDLLKSQESNKNFEKKNEINQTENYLEQQLLFKDNQIQKLNQKLVDYQQIEMEWQNLEKEKESYEKLKQNFLANQQELQSFQNKLANKEAQLKKIQKQIKKEQKEKYNYPKNQQGNQQQDNLEELNQIIIEKSRQFKKLKKALKIKQNELEEKQKQIEDTSSKLIFLENEAFKCGKGLENLLDQIKELERKIILKENELIQLEFVSQEARNIHNLLNQKELIEEELNEMKEEFKDISSKLKEAKNQLNFPSQNSPLQFNNQNKDNLDLLQKMDDLRKETENEGNVLFSHSKRKNPFSISSENRLMNNLQKDLNDKDDQELIDSIEEMKKDLENDIEKMIQLLQQNKELKLEIDKQLYFMEELRNQTQNKLNESIQKEKEILTKSTQLDSEIKQFRNEQILSSQNQNPRIKIHKKEAFPQVIGNRYLINQNFIENESDEYNRTFPFNQENENLLNQLKEKEEENEYLVNQLKEKEYLLNQLKEKEEENEYLVNQIEKLQQEIERLKNIIYNLELEKETLTKNTQKFIQENQQLKNNCATYREQLFQQQQKYRNLNLENEDLKTEIQLNEEKMKQKEDEANVLLKLGEQKLEIASQMMQKNDGNQYQFILNKLNEFIRINKQLQLKLQQISEERINQLNQLNQSNSNSNSNQLKPNAGNAIDLSKFRGKIKNNTISDYFNKIQQKEIGRLSKEISHKDRLMFSALNDLRKASQKFNPNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL09</accession>
    <name>A0A9Q0LL09_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA 5'-3' helicase FANCJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M0811_01197</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL09"/>
    <dbReference type="OMA" id="FSNDNAR"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000731">
        <property type="entry name" value="Fanconi anemia group J protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="8"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="784"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="929"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1020"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="929"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5074566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1176" mass="135484" checksum="13ACDF924C1DE991" modified="2023-09-13" version="1">MEPFQLKGYDIEFPYPKPYSCQVLMMENVLTCLENQENALLDFPTGTGKSIALLASSLTWQKEFKKKSFSLNQSDYKNTQEKSKNRFKNKIPKIYLSSHTHTQIAQLCQELKRTNYKPKMVVLGSREQYCINANVMKSEGNKNEECEKLIKSKKSRCPYYREMNKRFSKNQYDRYNINNEIIDIEDLKLIGSKNMTCPYYLSRDLAKEADLVLAPYNYFVDPKIRNQISLDLTDQIVLIDEGHNIENACREALSLDIELEDIEELTNFLFGTMTKFQHDFVQELFKPIADFVMSINELITQHKDKLQTSNDSGKYTYWTGQSLISLLKNHGITQFECDHLAEDFEKLLQKENTKFLSNSKNGGLPGETDVIDFGDELEMPKMKTSHAVFIETLLIILDKVFESPGDFYLVLSYHKKENPLFDRNQHRNFNQNQYQHQHQNQNQNQNQFSGFQSAKNQLNQQNANNPVMVYELSFWCMRPSVAFRMAFENTWSVVLTSGTLAPLDPFESELGCKFPIRVESDHVIDISAQACIGTIARGMEGNILNTTFKQIGSTEIQDSIGGVILEICKIVPDGVLVFFSSYSMAKNLKRRWEATKLLDKIQMHKQVFIESQGRKIFTKSMKDYYKAIERGKNNGRQNRPPKKTGALFLAVVRGKVSEGLDFSDRYARAVIVVGIPFPSTNSLNIKLKRQFNSDFGPPLLPGSRWYELQAYRALNQAIGRCLRHRYDYGSVILIDERFEQDYVRSNLPKWVRDHVKSWSATRNCLSDLSSFFARMKISPPVKPSEYNSFKSIDSQNSQNSQNSQNSRNRKKRNSPNPFSNSSNSSIQTSLNDFLIWRDQEIKKTKTTTRSNQKSQEIEEKSDSNFGLKNIYFSEQKGDFQNGKVLYDNLTKSMTKTLKTDSKTLKTDSKTLKTDTKTLKTDSKTLKTDSKTLKTDTKNDSKSGMNLLNSSPYFNQAQQPKSQSFTGFSLENKLPESVFPNNKVVYSQMGKGIDERNSQDYGNENEFFQNQFIQNQNQNQNQNQFIQNENIQNQNQNQNQNQNQNENIQNQNIQNQNENIQNQNIQNIPNNLQFRISCSCQALFYVYSETLNSLPKIPKFASVSLDGKVYRVACLDSEQQSYVENIKITNANLQIENWKNSCSHAVCTKCNAIVGFRTMLLKKDTFLTPILCLFVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLM9</accession>
    <name>A0A9Q0LLM9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_07533</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLM9"/>
    <dbReference type="OMA" id="ISIPWGA"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="776"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="826"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="856"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="923"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="993"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1001"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5075182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115570" checksum="8877571EA7655B60" modified="2023-09-13" version="1">MEKSKLDFTISIETLMSLNSIGEKREEKEEPKEGEEKKELTEEEKKEQAQKQQLALSKLKEIGGVEKLAEKLHSNLEVGLPQWEIKEGFIDRQAKYGCNRFAEPPHSTFFGLFFGTFKDTTLIILMVSAVLSLVLGLTLGDRSSDWIDGTAILIAVLIVSNVTAINDFQKEKQFRKLNKVKEDIQVKVIREDPEHSGAGAEQTISFFDINVGDIIVLSVGDKVPADGILFSANELVVNESEMTGEADDVHKSVNLKPQMLCGTQVVEGEGKMVVTGIGIHSQWGDAKKNFEKPPDPTPLQNKLDKMAVFIGKVGLYSAILTFVALFIGWIVWAIQHKSSFSRDRWELLVEYFIIGVTIVVVAVPEGLPLAVTISLAYSMKKMMKDMNLVRHLSSCETMGNATNICSDKTGTLTQNLMIASEVYLLNHHYKDEFPKLDDLNPEFIKESKETGSRTEIALMKFVREYDCDYQAIRKRYENKRPKIYTFSSDKKRSGVVIETNNGYRLYLSGAGEIVLGLCSSTLDENGKVVEIDDAERKNLNDILDAMASNGLRAITLAYRDFDEPQGDWSNEHDVQSNLTCYCIIGIKDPVRPEVPYAVDECQKAGIFVRMVTGDNILTAKHIAKECGILKDDGVAIEGYQWRDMSEEEQIALLPKLQVLARSSPKDKLTLVSLLRQKGEIVGVTGDGTNDAPALKEADVGLAMGITGTDVAKEASDIIILDDNFKSIVNSVMWGRSVYDNIRKFLQFQLTVNVAALVVAFIGALSQKGTPLKAIQLLWVNLIMDTMAALALGTEPPTRELLKRRPYSRYESLLSNIMKRNILGQSLYQLTVLFVILYAGGKIFGYNTKNEDEQTHLYTILFNAFVWCQVFNEINCRKIADENNVFKRMFKNPMFIFIVSITIVLQTLIVEFGGAFFSTKKLTWAEWLVCIIIGSLSIPVGFLIRLIHVPPDKVKIPAKKGKEKDTDKEKLLDSKNEIDINKDDDKDIELNDLKKEKDKTSDSQQFVTEPSDTANTDDFVTENTDTENKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLP9</accession>
    <name>A0A9Q0LLP9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="394"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="567"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="639"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="676"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="713"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="749"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="786"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="822"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="930"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="963"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1378"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1350"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1470" mass="173410" checksum="8B0020A27AA55755" modified="2023-09-13" version="1">MNIWEIIEKNKIELLKEIENIPEKEIKKENKNLLNFAIEKQVSKEIIKELILKGINPNLNDENGRNSLLISIMNKSKIEIIEILLQNKVSINSKDKHNKTALHYSIIYLQNSNLLETIKYLISKGIDINSETDENKTALHFVFEYQKENVELLEIIKYLISKGIDINHKTKYNKTSLHFAFQNQNSKTNEIIKYLISNGAEINSKTIYGKTPFHLACTYKDENINEIIEYLVSKGCNINSKTNDNKTALHFACQNQNPKINEIIKYLISKGIDINSLTSKDETALHILCQYQTQNPNLFEIIKYLVEKGIDINSRNSQNETILHILCQYQTQNSNLFEIIKYLIEKRININSRNSQNETILHILCQYQTQNSNLLEIIKYLIEKRININSTNSNDETILHILCQYQNQNSNLLEIIKYLISKGIDINSTNSNNKTALNIAYKYQNPNLFEIIKYFYENEIDINLANSYKKELILIQIYLKLSNILININSLTSNNETILHILCQYQNQNSNLLEIIKYFISKGININSRNSQNETALHFACKYNPWFDLIKLLIENGGKINNQTKQQHRTPFHLICNYKKEIPIEIIKYLVEKGADINLQDKKNETGLHFICRNKQKNTFEIIKYLIENNNHMNYKNKRNQTPLHLICQYQQENSLEMIKYFVSKGYDITDKDFRYGKTLLMVVCEYQNHKKSHEVIKYLIKNGANINLLNDNNQTILHIACQYQNENLFEIIKSLIENGIDINSKTKDKKTALHLICKYQKKNQIETIKLLIENGIDINSKTSDKFETPLHYICKYQKENILEFIRVLIQNGADINSKNDANETPLHYFCKYQKMNLLEIIKYFVENGADIHAKSTQGLIPLYIMFYNQKADLFEIIKYFVEKGVNVNEKTNDNETLFHLIYYIKIDNQIEIIKYLIEKGGDINAKSNTDVTPLHYACQSSSFEVIKYFVEKGADVYSKTKFNSTPLHYFCQNQKQENKFEVIKYFVEKGIDIHSQNDRNETILHYVCQSNSLEIIKYIVEKGVDINAKTNYGTTPLKCADINEKDNFGMTPLHFVCQYQKENSLEIVKYLVEKGVDINAKTKYNSTPLHYACEQKSFEVIKYLVENNADINEKNKYNKSPLSISIQNQNKNLTQFLLMNDANIFDLDVDQISNQVIEIFPKVYSFNEDLNKFFKSNDNFSDIQIQSNDSFKFNIHKLILLLRFDNDNSILEKFINICYQKPKEDVELVLNFLYTGFPNFDQFNQYFINLINFKKEFEESKKNLYNYYSYYNRNTSTIYEIKDLRKDKRSKEIENEKNQNEKIRKLFEEIGIDSKWIERKKGRKGIIKDFEKLYQENETKDFTIIISQNQNQNENENQNQNQNQNQNQNQNQFENQNEKEIKVHKLILIIRSELFKGMFELNVSDTSNQVHDYSRKRYETIQDFIYFLYHDKFQEEQIIKKQINLEEYEDLKDYYQLNSNSIIDLILNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMB5</accession>
    <name>A0A9Q0LMB5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_01030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMB5"/>
    <dbReference type="OMA" id="NDEYVEH"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF243">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5074400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="37001" checksum="4D978D3C9788EADA" modified="2023-09-13" version="1">MSLKTYYCYSCENRVEIAENAQLQCPECQSEFLEEIEESENEQQNEQQNQQQNQQQNQQQNQQQNGMGNNEFRNIMRLITDLARSSPDHPEQPLLQLLRILRNDNVLAPQESEEDIDQIIARIMQNDNNRYGTPPTSKKTMKNIKKKKVTPKMIHEKANCPICLETFSENQKYSELPCKHKFHHNCLIEWLKQHSTCPICRYQLETDDKDFEKKIKNQNQNQNQNQNQNQQQNSNQNQNQNQNQNQNQYEFEYEAEFEFDFPDENDEYVEHIISSNANIQSYEDVTESDSNDSDSNDNDSNDDSRVENSYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMF8</accession>
    <name>A0A9Q0LMF8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMF8"/>
    <dbReference type="OMA" id="MEMEPNI"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="421"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="467"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="624" mass="73231" checksum="6D4DF4C86DC306CF" modified="2023-09-13" version="1">MRMKNKNFFLFLKYFFFRKIRDWGEIFLFFGIVLYYLVRLEPFTGLHVYLQGGKFDKADRVFNSIAEAWNICQTSTSDVKELIPEFFYLPEFLYNHNKFNLGKRQDSEVQIENCLLPNWAKTPEDFIRIQREALESEYVSQNIDKWIDLIFGYKQRGKKAIIEFNIFYYLTYEKSINFDKITSPHEKKSIELQIEHFGQTPSQIFRQKHPQRFPLKQVIHNILDLTLYWRMKSDYRYRKFSSKISNAPIIFVYFSKTIETFSFMGISDKILTIDENRYLGMHSCFFINQNSMEMEPNIQEEKETNETKKGGNLIENEPQKTANDEQQIFVNKSKSKLQSQSQSKKIAYQKKPENSKDHFVFQIDSQYFNRNQLGYSYSPKISSFATCFSFVQARSLLFSCGYWDDSLKIIDIEKMKILQSITNHSDIVSCLDYDSGYLATGSYDTTVMIWRFNEEQEKIEPNPVHVFYGHDNSVTCLGISVDLDVVVSGSEDGTCMIHTLFEGKYVRTIVNENFSPLTLLKITKEGFLVTFSENDLVLSVYSINATLIAKKKLTENIKCFDVSNDSKFLVVGTQQKNIHLYNLYDISLIQTFEVDDSIISLRFYEVWRFILAGTSQGKLIILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMR5</accession>
    <name>A0A9Q0LMR5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMR5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="507"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="546"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="578"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="613"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="791"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="896" mass="106194" checksum="DBDA30AB4B6DF981" modified="2023-09-13" version="1">MGNKESKEFKELKNVELDERFLMLKKKYGSSFLKFIADLKPLDFELIQYAIEQGEKLNAKTAVKSKRNIIPIEKKCVNFVLIFNQNRDEKITLDILDWLLENGGDLNLQFLTPLHMLCDNRSTNTETIRFLIEKGYNLSLKTLTSFHMLCDNKSINTETIRLLIEKGYNFNMKIDTPLHFLCRNSAIRIDMLRLLKEKQVDFKMKNVSEKFYQSKRNSQKIPFFFIFFFLERCIQNDHLFKKKNITNSQFQFLLIFQKQTPIHFLCKNSSINIDMIRFLIENGADFNMQSETPFHLLCKNDSMNSDILFFLIEKGANLRLRNESAFHFLCRNECMNMNILRFLIEKEIKFNRRTETPLHFLCQNRSFNTEMLRLLMEKGVSFQKKSETPLHFLCQNRSFNTEMLRLLMEKGVDFNLETAVKNFWILSFDFRKLSSIQYLNLNQNNRTRNLNTEFIRILISKGFDLNLVNETPLHFLCKSDDINPDIIRILITNGANFNIQNKNNIIKDNTPLHFLCKSDDINSDIIRILITNGANFNIQNKNNIIKDNTPLHFICRNRILTSQMLRVLVSNGANFNISNGTPLHVICERKEISLEMLKILIENGANFTIPIETPLHILCKNKKFNLAMFRLLVERGANFNIKDDVGVTPLSLCEPLFQTLHSSFLSFLEDFQNLFEKHELTDFQISKFPVHRLMIELRTGKKAEQVRETLEKATENQIMKILRWIYFGRFKRLNSSDTIAKKQEEAETQTIYKTQEELQLYQLLKQIGIENPNERNIFVDIQKLYYQDDTKDFQIEVEGKNLKVHKLILQARSQLFRQMFISVDDKSNRTKDFSEQTYQNMSLFIKFLYTDRITQQDYEEMITKQENLFDFDFFFDFFQLHPNSSLQFYKEKFKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN25</accession>
    <name>A0A9Q0LN25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN25"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="115" mass="14115" checksum="04AAFA86251A2C88" modified="2023-09-13" version="1">MKLSKIKKVYQKDGLNIMILFLQFNNSNPKNNLLYEKNLNSNEINLVHDFKERLEKYQKEIYKYFIKLPNPKQATMNYLKNFQDNEKNLKRIILFIPREFEKKHSKKQKKILKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN79</accession>
    <name>A0A9Q0LN79_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Npc intracellular cholesterol transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN79"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040476759" evidence="2">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Niemann-Pick C1 N-terminal" evidence="3">
        <location>
            <begin position="64"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="268" mass="30473" checksum="78D299F6C0AF18EA" modified="2023-09-13" version="1">MEKIIIILIIICLTRGEKTIKKGVQAEPTPMCVWEGAPPNGPVIYKRPPQQADPPVQDCIPIQNGTLGGCCNYTQMLYFTEKFKTAISFFGGCPACVNNIHTTWCHYDCDPYQASFVSTTNHEDGQPLLYPKLTMCRRWAKAVYESCQWVHFVSSMWPTYEAFWITQGGDTLPIAVEVLYPENDDDPFALCPLDELEKCEDSCDCLTCPIACQSGQMPPYENDEKKVGAISQFNFWMIIGCSLIGIMFLFVIFKRSQEFFKEKKLQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNQ7</accession>
    <name>A0A9Q0LNQ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_07486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNQ7"/>
    <dbReference type="OMA" id="WAFEVEL"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="303"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="447"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5075135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="504" mass="58599" checksum="CF1FDCC25D95ABEE" modified="2023-09-13" version="1">MERRKLPSGNTFEATKKIGQGNFGKVYLGRILLTNEKVAIKEINLTKSQEDKKKVLRELQVMEKIKHQNCVNLFSIEPENYQDADLIYVVMEYCDLGDLNEYLELKKDKNEKLSIEEVTEIFGQIVLGLRFLYEKGIVHRDLKPENILLQSNDDSTFGYRIKLADFGFAREIPKDDYGESIKMNSFIGTPLYVAPEILLNKPYTSNVDFWSLGAILYELITGFLPIQATSIKNLKKQYKYLAKKSLPKAYLNKLQPECNDLVERLLTVDPKLRISKEQLYNHPFIIEKLKELKEKSIEIQDLEKKIIGITKKDYKSKENDKLSFKKGEIIEIIKINKDEGICEGKLKEKEGIIELNRIDLYEEIKDIFSLIESNSNIDNNQIKKFQKRIIGIVSNNYKSKQFSLPKGNLVKIIKINEENDSCEIQFGNQKEEIPFFFLDFYEQIGENDENENEKEKEKSKSKSKSKLKSKSKSKSKLKHHSKHGKKDGKKDGKKHEKDEKDGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNY5</accession>
    <name>A0A9Q0LNY5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="2">PARP</shortName>
            <ecNumber evidence="2">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411019at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1056"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="1354"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="741"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="867"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="645"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="956"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="763"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1597" mass="189123" checksum="8804F88A4469A5D6" modified="2023-09-13" version="1">MGTPQSKIQTITERLETQSKNAELWNARGQEYMKINKPNEAISDFNKAISLSPNSVQFYMNRANAYIQTHDFLRAETDLNKSIKLDPSSQQLKNQKKEFESFFNDFLQSIKKNIQLVTLSHDSITIGLIDQSFYSSINIFLLSESQEKKSENFNKAVTFKNLIPNKKYKIFLMDTNEKNLCLEVSTKEVPEAKAEIKNCSYCSAEVEILWDGYDQKNTEFSVSCANNRSILFHYHVEPLDLSRILLVLRGLALNQKHQVSILIQDKRWNFHQNFHISFSTKNVDLSLFQVVIDKKNEFFRIIAIDFWMQKRTTISNQNELNFVNSQFAKIGKKIESSKNTQNTIKYLVQWLEIYDSIKSAISEYKQLKEGHENFQKKIEEYYTQYFDTNQKQFLVDGNENSNQNQNQNQNSNQNQNQNQNQNQNQNSDQIPYNPNLHSLQAKQLVSKFFHFYNSFLDLIKHFIDQTQWENQKTQNNLQDMFLEFDSFLSSCAQILDGYSAKLIEFRDFYSRFFGEFEKQAFRFQTLRNNYSILEESQKSFETLKKIDKELEQPEIFHFISLLKKDISRNRIINGYKEEKQVLDKISDKIRNLVIGIATQNQNQNFSNQDEKKRNSLIPSNNVNISNEKNQKPKSQPNIKKNFRRRKKINQNQNQNQNLNQNLNQNQNQNQNQNQNIIQENDEKNQNSKKELKDLIEIRDQKRRESHKNAKLILEMIYQDLKEWHRLYETRERYQWQLYHQEKEKEKEKEKEKEEEKEKEKEKKPKRKKNKNHQIQKIKKYPSVVSPKKRSLSVNVLHKTKSQKLLVKDRHKKSNLNKSSNGKNKETKQKTKNNLVKTLSSTIIKLYNDLVEASTKFKDEMENIKKDIAEKKGKMNTKEEENKNENENEEFQQKKMPKNWIETFILNRDNFMKNFDELWGVLLQRKETKIGNLSKKMVEFDSQVKYFEDCFEKLGILEKYSEEINEINEKIDQVEIKQFELKKWYKRAKSNLEKRKELQVQMNEKKEEKRVLKRAKEEIGNKIKRVCLADYPERILFTDDFELEFGGIYVENSVEDYRQLQELWFIDYQGMFVNRTLEKDYTIINDPEKKLKGRHTIHLCKLNPRTLENANQKALKFEEDLCVVKVIPLSKISYLKRTLVPLMELKHPSIIKLDAIFIHNNSIHLQFPFYQNGDLKHFLSTHPKVRTEDIITILRQILLAIEYLHSKNVIHRDIKPENVLVNQSSRAVLSDLELCKHSEWENIYTQTLTTNLKGSIGYIAPELLQTHEKKQPLIYNEKTDMFAFGKLMENIALMHKKLLKIPQYKILLNQLTNKDPEQRPLSTDVLTSSLFIWGIQSNKFFAKIPQNWVLYQEIKNKKKNPDDLENWKKSIEITNSDFFKKISNWINSTFADSSDLGFSKMNVTSIYRNENIPLWNDYLEAKNRLKRKIKYLKSVNFAVEGISGKSIPLDCLDSEMNEYYLFHGTKHTLIDIICESGFDERVSRQGMYGNGIYFAQNSSKSAQYCSSPNGRDYYLLVCRVLLGVVFYESHQARPDLRRPPLIDLPDSSGLIFDSIFVRGRHKKFADNIPTAPVNFREFVVYDRFAVYPEFKISFQKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPE1</accession>
    <name>A0A9Q0LPE1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein rab-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPE1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="23900" checksum="E5684A8B6DAF64CB" modified="2023-09-13" version="1">MSFDALYPIFLVGASGVGKTSLIIKYVDDVFNLDLKSNVGIDYITKDVSVEEEEIRLQIWDTAGQEKFQISISSFSIYKNAKAFIIVFDLTNEDSLQEVYNYLLEINNSYKSDILIVLVGNKCDLENQFENLEEKIKEISNEKEFKLFKTSAKEKINVNELFYYIAKTLKEKFPQNENSNKDKPKRHSRKIIFEQEKKEKKKNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPK7</accession>
    <name>A0A9Q0LPK7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dilute class unconventional myosin isoform c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_06218</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPK7"/>
    <dbReference type="OMA" id="EIHISKF"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF861">
        <property type="entry name" value="LEUCINE ZIPPER HOMEOBOX-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="12"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="12">
        <location>
            <begin position="715"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="702"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="915"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1023"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="921"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1108"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1157"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5076638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1274" mass="149883" checksum="E3C901F1AB95DF25" modified="2023-09-13" version="1">MSKISEIEIPFTIKDDLLNLSKPSINAITKAIKKRFDSNNLHTYIGYYLVRLNSFQTFPLEITKKTRFYPRRFYPPDLFAFIDKIYLEMIEKKQNQLIVLNGESGSGKTQTTKEIMEFLLLNSLIENENQNIKKIQSCFKLLEVFGNAATKQNPNSTRFESFFEIHFNKKGNICGMKVNKIFIESSRIYTRKKGERNFHIFYQLLRGLKIEEKEQLGVSSIDEFNFLTQSGRFSIEGVNDSHELVKTQQAFNDLGITQKTQSKIFQILIAILFIGNIQFEEENENAIISNQTTISWISSLIKVDPNSLINSLTFKTISSEISTDTISAYSIPQTLNEAQKTRDALASEMYSRVFEYIIEIINKNLNSNQDHEFEIKILDYSGFQKIDKQDLNGLFTNYLNEKLQQLSTINILKKDQSQYQKEKIKWQNIPFNDNQIICNFIEDQDPNGIIYSINKSCEDPNKYELDQLISQIQKIAEKSQKKIKYSPKKQSEFIISHFFGDVVYNIDNFFQENSRMIQFDSIVMLQTSKLKLIKKIFSANIANIQNKTGNLLGTKFIQIIQELEKNIQEMKQHIIYCIRANNSKKLNSFESKYVQQQVDSMQLVPLIKMKKRVSFYQESPKHFINDYGIISNQTWPEFRGELQLGVKIILQKIEANEKDYEIGESDLYIYKPEIIVKLDKFKQIKLDEAAIKIQKSYRKYEEKMNEPKEREKDSNQNQKLRTSRPKSQVHKNNMFYFSNPEIIKLMELYSYDSEKLLYSNEIHRIKFTKLRSKPKREKSAIILTEDALYLIGSRRKKRKSKGKDESELKITTRLPLPEINEIHISKFEDPFILFKVSKQDIFIEDENKSNFIKILTENRKSKRASIPIQVNNSLEFIGKSRKSMKIQFQNDIGLNSNLFLQKKRNSLIINVSNVKKNSSKSNEKEDQNPETRKRGYSLTNKFPENSQNNIFKNIPKLNIEDLDSNQDMKRSQTSNLLLSPNTPRKANRFAINLLLESEDFPEFIKKNSQEIIGIEKKENLEKPKENLDKDNLKKDKENLKKDKENLKKEMNEDNILDYVNQQIDKLGGFVESENESENENENENENENELNNELKENSEDESEYEYEYEIKRKEKEKEKEKENQKENQKENQKENQKESEDESEYEYEYEIVDEKNQNQNQNENQNQNQNENQNQIQNENQNENQNQIEIEKGILSKNLPNEIAPKSQKPKNQFINHVIALFSFEGKKNDELSFEKFDIIKIIQKNSNGWWKGEKKGKQGIFPSIFTKEIKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQL6</accession>
    <name>A0A9Q0LQL6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQL6"/>
    <dbReference type="OMA" id="CKRDYAT"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27650" checksum="0FE4BA36E4AD69AF" modified="2023-09-13" version="1">MNQKKNLLELIIDGDLKSVKLEIENGADPNFTNKNWSPLLVASQKGNLEIVKFLLSKNADINHQNNGVTALYIACQEGHTDIVRELIANKADVNLNSGVSPLLIASQEGHLEIVRLLLDANANINIVDSGASALHFATSNNQIEIVKELSEKKANPDIQDRGDTPLILAVDNDFEEIAKILIKAGASFTLKNHGILCKRDYATDPELIQLMESNPKTRKKTKNSKKSDTNKKTRLKKGKGLFRACTSSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQT6</accession>
    <name>A0A9Q0LQT6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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    <sequence length="2519" mass="295276" checksum="4B307CAC894729F9" modified="2023-09-13" version="1">MNQNINQNINQNINQNINQNINQNINQNINQNINQNTKQNINQNTNQNINQNINQNINQNINQNINQNINQNINQNTNQNINQNTKQNINQNTNQNINQNTNQNINQNTNQNINQNINQNMNQNINQNINQNTNQNINQNTNQNINQNINQLKKIYEAILKNNIQFFDSISTLKTTEQFEKENKPFLNYAFENKSKKEIIQKLIEKETNLNWIDKNKNNSLHSSLSNKNPNEIIELLISKSSNINSKNKWNEIPLYIALKNKYSKEIIKLLISKGSNINSKNNENEIPLHIALKNKYSNEIIELLISKGSDINSKNKWNEIPLHIALKYQNTNEIIKLLISKGSNINSKNKWNEIPLYIALKNKYSKEIIELLISKGSDINSKNNENEISLHIALKYQNPNEIIKLLISKGSDINSKNKWNEIPLHIALKNKYSNEIIELLISKGSDINSKNKWNEIPLHIALKYQNPNEIIKLLISKGSDINSKNKWNETPLHIALKYQNPKEIIELLISKGSDINSKNVLNEIPLYIALENKYSNEIKILLMRYLNIFELKENEINQEIIDLFPKIYSFNDDLNNFLKSNEFTDIEIKSNDGEIIKAHKQILLIRFNNNPTILTRFINICRRKSKKIIQFALNFLYTGFIDFDKFIEKFNNQFIQNQTQFNSNFQFLFSNQIEFENQKKEEELNSNEIENKKEEFEKELIYDLFEETGFDLKWIKEKEGIKGILKDFEEFYQQNETKDFKIIIEKKEIKVHKLILQIRSELFKGMFLNVNDSSNQVHEYSEKSFETIQQLIYFLYNDKIDETKLTKENIEEFTDLKDYYQLNQKSILGSYLLDFYFKSLSNNQNSNLYPNENKQNQNTNQNTNQNTNQNINQNMNQNMNQNINQNINQNINQNTNQLKKVYEEILKNNIQFFNPISTLKTTEQFEKENKPFLNYAFENKSKKEIIQKLIEKETNLNWVDKNKNNSLHSALSNKNPNEIIKLLISKSSDINSKNNENEIPLHIALENKYSNEIIKLLISKESDINSKNNENEIPLHIALKNKYPKEIIELLISKSSDINSKNNLNEISLHIALKNKYSNEIIKLLISKGSNINSKNNLNEISLHIALKYQNSNEIIELLISKSSNINSKNNENEIPLHIALKNQYSNEIIELLISKGSDINSKNKWNEIPLHIALKNQYSNEIIELLISKGSDINSKNKWNEIPLHIALENKYPNEIIKLLISKGSDINSKNVLNEITLHIALKYQNPNEIIELLISKSSDINSKNNENEIPLHIALKNKYSNEIIKLLISKGSDINLKNNLNEIPLHIALQNKYSNEIIELLISKGSNINSKNKWNEIPLHIALEHKNPKEIIKLLISKGSNINSKNVLNEIPLHIALKYQNTNEIIELLISKGSDINSKNNENEIPLHIALKYQNPKEIIKLLISKGSDINSKNILNEISLHIALKYQNPNEIIKLLISKGSNINSKNKWNEIPLHIALKYQNPKEIIKLLISKGSDINSKNNQNEIPLHSALSNKNPNEIIKLLISKGSNINSKNNQNEIPLHIALQNKYPNEIIKLLISKGSNINSKNVLNEIPLHIALENKYPNETKILLMKDLNIFELKENEINQEIIDLFPKIYSFNDDLNQFLKSNEFTDIEIKSNDGFIDFDKFIEKFNNQFIQNQTQFNSNFQFLFSNQIEFENQKKEEELILNEIENKKEEFEKGLIYDLFEQTGFDLKWIKEKEGIKGILKDFEEFYQQNETKDFKIIIEEKEIKVHKLILQIRSELFKGMFLNVNDSSNQVHEYSGKSFETINQLIYFLYNDKIDETKLTKENIEEFTDLKDYYQLNQKSILGSYLIDFYSKSLSNNQNSNLYPNENKQNQNTNQNTNQNTNQNINQNMNQNMNQNINQNINQNKPKHKSIKKKQFEKENKPFLNYAFENKSKKEIIQKLIEKETKLNWIDKNKNNSLHSALSNKNPNEIIKLLISKSSDINSKNNENEIPLHIALKNKYSNEIIKLLISKGSNINLKNNLNEIPLHIALENKYSNEIIELLISKSSDINSKNNLNEIPLHIALKNEYPNEIIKLLISKGSDINSKNKWNEIPLHIALENKYSNEIIELISKESDINSKNKWNEIPLHIALKYQNPNEIIELLISKGSNINSKNNWNEIPLHIALQNKYPNEIIELLISKGSNINSKNKWNEIPLHIALKNKYINEIKILLMKDLNIFELNQNEINQEIIDLFPKIYSFIDDLNNFLKSNEFKDIEIKSSDNEIIKAHKQILLIRFNNNPTILTRFINICRRKSKEIIQFALNFLYTGFIDFDKFIEKFNNQNSNFQFLFSNQIEFENQKKEEELILNEIENKKEEFEKGLIYDLFEETGFDLKWIKEKEGIKGILKDFEEFYQQNETKDFKIIIEKKEIKVHKLILQIRSELFKGMFLSVNDPSNQVHDYSRKSFETINQLIYFLYNDKIDETKLTKENIEEFIDLKDYYQLNQKSILGSYLIDFYSKSFSKKSKLINNFNFNFNFNFNYNFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSX2</accession>
    <name>A0A9Q0LSX2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="BEACH_dom_sf"/>
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        <property type="entry name" value="BEACH_Domain"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
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        <property type="entry name" value="Neurobeachin_a-sol"/>
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    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="3096"/>
            <end position="3105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3201"/>
            <end position="3211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3224" mass="378305" checksum="AEC112AAFDC106C6" modified="2023-09-13" version="1">MKKTNSPKNQNKNKNKPRKPSLQKEDRNLIPKFLGNENLINLYIKKDQFIEAISLSNWFYKFSLEFIDTYQNWFPVSFPLKNQFKINSDIIQNEEFIQEAIKQDACHPKDLILANITILKQFCNLLFEKLKEKSISDSTQSENETKNQEQMRKKIEQSSFSLYFSAVSLEMLMILSRSKINQLFFLEHNLCFILAELTKPAIILYSKIIEKIRTHIDEKDQRFKESRKRNFLFIQYLIEKLLQIFLIYIEQILQMESEFEELIEFALAFVDNITSFENIVCLTEAHFNILFHTINLLIILGSYSKIKPKWINKILDYIFRNALQPLNDSLISLGTILSFDSHIDIDDQVKLSQLRKEFFCYQGTSDSSESFEKKILPQLIEFNSPLNHDQIMSNWFKTKLLNLQILRSLISENTENEFLVCKHMHLEVICDLILNIFNNFFLEDEKNIISNENLENENLKDEKNIWENNFQISISNTANNIQDPLQNDDNFLEICEDPRTKTQIVIYTKMPKLKYYQSMYLNQLFQVLSDISTQSYRNQLKKSRTSKTTTTEKYKKTNYEKSSLRIKIIAICLNIFNRYFRNTEKNATIRKKIRNFSPELQLYVLSLLTNTIHEEDEFLVSNEDFWGKLFSESFYPDLSMKNYVSDIKENKFMLIKQIIFSLLFIFAMRKKNRHFAEIRALVNILQSNTTNIIVIHEISQLLLTIMHKNGNIIGKPFIRDFALPTISIVARVLSIKGSEVLEQIRSENEEDFQKIKEMRKFAKISIFELLDHVLLNEKVKPSLIKDTITINTLMDLLSDTETREFAVKHIHQIAVDLTLENAEKEKQGIFLSVLVDKMTGYLQNMLLKQEVENDSLNFLLEISRLLSSVVVQNPIALQTGLREVGFFDSLLSLLANPLIRNKMTNIVLQNLIGLFRGSRTNIEYFKHNYGFDSLGVLLYEAENHEPSDSVYSMILDLIVNNRSFDINQNYAIDLPDAVLLFFSLFSKKEDEKFSSMINTLLAICNKSVHNKSSCCEAGLINILIETIEHVQSPEIGQALSSLLGVLGAHRITVPELRLLFKKLHIFSQQNRAKHPALFIRAMKQMITNNKHEPPIFFDFDGRTSCLKIPSLGSWPPIEGKGISFLVWLRVESFSSPIHTQIYQPRLLSLLTPTCQGIEIFLDPLSQSLIDDNDANLCINFLSKPRKTNSVAISTKCKISAHRYHFLAVTISFQKRTIAEFRVYLNGNFSERILVNVPKITGTLSSNHIGAGYICEDKQELVLANFFFGQMGCVYIFDDILSSQQIRGIFELGPKYISSFHPSEQTVEMSKNFEKSPHFSNVFARSLNEKIFFNFNSKACENGVCIDQSPKHSSLEIQAQTEGLSRCFTCNFVDILYCVGGMRLFFPLLVQLIKTKSDPNENENLDQKNKHSFSLVFEMITEALLISSINQDDMVRARGFRILCYIFRKTPPNWIEFAMVENINRMITEISEAHFLEELIANFILDFDIWIYTARSVQEGILNIISSAMFDRRQMKFRKCWITVSRLMWILVAYYWIVPTNFSRAMKARKDNNPEKTHLPLLTIQDVQYLQSVLLKSISNFLENEFSPSDLVHVFNTCVYLREKDNTTMFSVLQVAHHVLEIKPEAISQIPDLFHTIFMFIENSNISICEFGLEMLFWHTQTSQHKRKTLNLQPVQDDEDWVRYIGMLLVTLPLSRRIANILFSLMFDTKIEFGKNQERLFFSQPICRPSVLSVLLASISKHKNQPALTTLKMISKLITKNLDTTSILLNQINWRQRLILIFDFSLVSSDPNPLKLIKKSLETSLPQKPKSRANILREKFNNTILKIFTHVHTHRIGIKNGWSDFDQTIVVVQKLVQLTSLERHKLLHLLSLKMIHKLSKRYNSNTAISNITKMERGNIAHLGILICKILILIKSNKFGTNITNQKNMTDISDVEKSKKNKFLGKLHMYSMRTIAAKNVSDWEANLDEDVIPEKDEKMEKNWNFEEKTNFLVFKVIEFLENFGFFRNRRNMLDKPTNQEFFLSVSDLLLEAFGSVSSQKEILKKIKSFIIEPSLKELPRNFSDSQVYTKLVLALWDRLDNDGLVDAQEEEIQQLIGDLLDKCWIIVKNLNTSILEPNIQDIQMISGFKTNNRNPAIDLVFTKFRTEVENLTNEKLKTIKTEMKEKAAILRQAVKKQVLIDTEACNNFQFRVNQKYSEIHQNQRKKNMKEESFAQKRFYYSGYLWEKCARWLTSERGPWSVNLDSKESSSQKLWRLDSRIDSLYRRRKTKVSYKDTHKYKIAAIRRDKKISKYKAIDLLESQKITESQLDSFPLTFPEDNVYMQIDWKNEPQDPKKSPENFEVSEKNEETITNKNDIILIVPCQLIHMYQEIEGKIQISHKKIIFLVKQNSEDENNNEQKESVQKPKYESAKKSGDRSWRVKTIYAIHKRRYLFCHSALEIFLTTGKSFFLNFSVENRSKVYHELLMLHPPNLMYHSISSDAAECFQKEEYTKLWQTRQISNFEYLMHLNIFSGRSTNDVSQYPVFPWILSQYESETLDLSDPSVYRDLSLPIGALNPTRLENYIQRYKQCKQSNTLIPPFHYGSHYSNPGIVAFFLIRIEPFTSLALRVHDEKFDSADRIFYSIGSSWINCTRDLQDLKELLPEFFYLPDFLMNINNLDLGVKHQGDRIYNCILPRWAKNAHDFIRIHRQALESEYVSANINNWIDLIFGNKQQGKSAVKANNLFYYTTYENNINFDSTQDEQELVALKIQVKNFGQTPIQLFKRPHPKRLTLSQIYSSNGFFYHFNLRKFDANQFSKLEMFQIKAESFHPKSSLKFIGLSNVQTFSFQYQLSNDSGWFYLITFDLDRRLGFHKFKPNLQKNAEYLEKLIVLLEQEPKILNNEKQNLIENENENEIENENENENENENENENEKQNENQIEKQIENENEIENENEKQNENENENQIENENENEKQNQNQNENQNENENENQIENENENQNQIENQNENENENQIENQIENQNQIENKNENINENINQIENQIENQNQNQNQIENINQIENQIEKQNEKQIEKQNENQKQIENENENQKQIENQIENKNENQIENENEKQNENENQNEDQNQNQNQNQIQNEKQNENINQNQIENQNQNQNQIQNEKQNENENENINQNQIENQNQNQNQIENENIIENQKQIENKNQIENQIENKNQNQNQIENQNKNQIENQIENQNQNQKMKMKKSNENQKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTC0</accession>
    <name>A0A9Q0LTC0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTC0"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10141" checksum="B099DFD47B7366B4" modified="2023-09-13" version="1">MKLKQILRTLHHSGINFPSFSNHSSSIQYRKQKVHSLFMPFLSLIIYMIIKILLIIMDKQDFQQIKHKGPDSFQKLLCHLNGELSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTJ8</accession>
    <name>A0A9Q0LTJ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sh3 domain-binding glutamic acid-rich-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000050">
        <property type="protein sequence ID" value="KAJ5078682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTJ8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="196" mass="23441" checksum="168E693C125C85BC" modified="2023-09-13" version="1">MQTQMNWYQRDPEILETAQILVNLKKEIQQRKVNYQPINEEFIKTIRKETEEEKQQTERKKNEEKKEEEEKKKEEKKGENSDDEFLFKFRNFVTQNPPPRVGFRLSYISQFKPDLIHGWNPDTVIHAKNDPPNQVEIEDDLFVMVEKSTGQSKKNVRRSVAAYLAKIGLENITKYQRGKMVFKRNLNRKPLQSKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTQ6</accession>
    <name>A0A9Q0LTQ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTQ6"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="293" mass="34900" checksum="E8932709496A0A9A" modified="2023-09-13" version="1">MESYLNLKKLSNDLKNLFQNQNQNQNQEESYFDFEIICEQDKTSFKTHKSILSSRSQYFKSLFNSKMKEFQENKLILKDVSNSILSSILNYLYSGKIKINLENAIQILIFSSKYLIDELIEVSSKFIKKNTQMETVVDVLKLSELMNLTQLLDSSYQFISKNFNEFIKTPFFLELEENHLNSILLNDKIRINEFLFFQSIIKWGKHKSNINQEKENQKLEKEEKEKLQDQISNIIDKIRFIDFSKEEVEDTLKQDLIPNQISQKLIQFQKLQNQNDELNQFTKKKIHPFSNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTQ9</accession>
    <name>A0A9Q0LTQ9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTQ9"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="161"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="442"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="559" mass="65188" checksum="4E15E5B8698CE203" modified="2023-09-13" version="1">MNEILFFGRFSTIFLFENGKAIEYLNEKNSKQNPSKIQIEENIQKVTVGYVNVSILTIEGNVFAKGYDINPNNPHEFINISSLIEDINDRIIEDIVSGAYSVYLLTSNQNVYVFGSNNNGQLGFDSETLPKTEKPILMMKNVSKIFSGNSSKHVFLLNSNQELFGCGDNDRNQLGLGKSTRNETKIQKLTKIQNIPKGEIIDIQCGCIYSIMLIEDENQNPKRKFYSCGNYQLNGLGKLYRDTYEFTEIKSSLFENDDIIDFSCGYSHTLILTSNSKLIGFGNNQQGELGIEDTKNQPIPIQIELPKLRFNENISNYHISCGYEKSFLYYSPFFSNLEEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLNQNQNEIEKLKEIISKKSIKESNQIFEMIYSNNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIKKGIDYFQLNQTNPNLIDLLINKFNNQNQNQKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTU2</accession>
    <name>A0A9Q0LTU2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA repair/RNA processing cpsf family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTU2"/>
    <dbReference type="OMA" id="HQDFLMR"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="23"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="429"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="815"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1187" mass="134553" checksum="C6EFFE5B3459260E" modified="2023-09-13" version="1">MENKNRINNFNCNYVVTINPPTSITTSTTGKFTSPKDRNLIVSKNTSFEIYFITSTGLKPYLVVPIYGSIATLKLFSIEGKEQDLLFILTQEAKLMILSFDSKTETITTVANSNLKQKIGKKNEIGAVGLISPNSQAIIVYFYTGFLKYFPIDPNANLLNSNKDDLIINGGAENAAFPVFSEAFDIRLKELIVHDIVFLYSKYNELLLCVLFETANDMRHIKTYVLQKELLELKKGPFSRSNVDESANMLIPVLPPFYGVLVVGNSKISYINNGSFITTKIPWGFYIAFGVIDASRILLGDHLGNLYLVALIKKTSRKSKSIENEKTQEKQVVEIKFVKLGETSSPTSFSYLDNGFVFVGSSWGNSMVIQLQNSSTPGFEVVDEFRNVGPISDFCCVCPDDSGQSKMITCSGAFKSSSLQLISNGILINQLSSINLPGISGIWNLKQFKKQKENKTEKLIDNLIDKFVVLSFFQTTSILEVKGEQFQSVEFNGFAYDSQTLCCFQMILPKEGKIYTIQIVPESIRVIETSKWELVSTWKPPKESRILLAEGIQYEQENSTFSKVILSTSIHDIIMLEISSDGKFSQKGIANFGFEISCINLHENLDIGAIGSWEDFSIRLINLKNMQEICKVDLINDVLPRSVVLISWQKELYLIIGMGDGNVFTFNLDLETYQVKKKRKFVSGKTPVSLRKLKCFGKEIVFVCSDKSSVIHSENQKLLFSSTTVNEVNQISSLNSKYYSDCLIISSNNTLSICQIEEFQNLNIKEFPLNEMARRIVHLKKMKKYAILTSVISTNEDQQKSEMLSNEIPNQIEKNHLRIIDENTFEVVGSFEFDNQETALSIITIEMDENSEIIIVGSGISKSDKSGPDWGKIRMFSIEKKMNEENSNENSNENSNETLKLQMIAFQEFGGAVFSLARYKKRRFVAGINNQVFLFKITESKEKNQSLFFLYQGYQIGSMASLHLQTIKNIVFCGDSMKSVRGWIVGKTDYIFNEVCRDFYPKRLSAIEILDENHLLVSDRNCNLYILYKKDEDQDNLEESYRLENIGPFHTGDVINKFQKCSFVMKTEENEHLHSSSIVYGTISGEIGLIVSISKEDFILFRLLEKILGSIIVGVGGFTQEQFRCFDQGLDDSNNSYQGFIDGNLIEKFLDLKNNEMEEIISQINISRIKITIDELIEKIEKMKQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUJ4</accession>
    <name>A0A9Q0LUJ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUJ4"/>
    <dbReference type="OrthoDB" id="298084at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="70"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="402" mass="47476" checksum="CF2822E8A04692D0" modified="2023-09-13" version="1">MKEYQENKLILKDVSSSILFPILNYFYSGKIEINLENAIQILIFSSKYLIDELIEISSKFIKNNLQIETIVDVLKLSESMNFNQLLDSSYQFISKNFKEFIKTPFFLELEENHLNSILSNDGILINEFEIFQSIIKWGKHKLNIKQELEKEEKEKLQNQISNIIDKIRFIDFTKKELADTLKEELIPKQISEKLIQFQKLEKQKNEKELNEFIENESSFIFKTRFTFDSEIIQEKEHFNKLKEWINDNYFFSKMKKGFSAKKDGFDCKIWHKAVDNKGKTLIIIKTKDNFIFGSFTKVGFTTDRSKWNHEDRKFDFGFIKPEKFPIKKDQIKYAIYYDLHAGPSFGIFGDILFKSKLQPGDSNFGSSYNLPKGIKYGTNEAKSYLGGSYNKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUP3</accession>
    <name>A0A9Q0LUP3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_03801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUP3"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5080316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="767" mass="87856" checksum="9AE8F0D1D7BEBEE9" modified="2023-09-13" version="1">MESPIVLTNSSSMIKAGFGGDDAPRAVFPGIVGRSKYPEVMVGMGFRDYYIGDEADSKRGILDLKYPVTRGRITNWDDMEKIWHHLFYNELRIAPEEHYLLVQDSFLGPKSDREKITQVLFETFNVKGLYMLSGIESALYSTMPSGFSLFVHIGHGSTQILPMDFDKPLIDYGIRQDFAGQDLDDFLRYNIVRENDIFFHSNSESRIIQKIKENLCYVTYDFEEELIKNTKSIIKQYELPDAKVINLTRTRFAVPEILFSPSMFGFSQVGLLPLIEQCVSKFPKSTQDELLKHIVVIGGSTMFPGFVDRFKKDLSKSSPNANVFADDFRKYSIWIGGSVISSLTSFSEKVIQSSQYDDQGPEVIHQHTKGAFLESERLFTGVEFLDRISPSFFQSQENICIIDQGTDSFKIGFSYDQEPKAIIPSIVGFEPFGSDKKQYIGEEAIENRELQLNPIFKEGKVENWEYLTAMYDYCFKSLGTYPDSTSLLLTRPLNSSNPDTEKMAQILMEQMKLPNLAFAFQPHLASYALDQIQTGIVVDIGNEFTQILPFYQRSYPLLSHKMPSMHYGGKHLTEQLIRLFRHRNYVFLTSAEFELAKYIKETYCYIARDFDQEYANFQTSTKEQRHIKLNGESILLDNESFSSLEPLFNPNLIGLSYPGIHQAIYDTIMLFDQEKQRELSKNIILCGGSSLIPNLVERLQTELSSLLPVNFNLNVFRAPDSDVRTLVWRGGAAFSKSERFSRAMFSSSDYFEIGSSVIYEKSFEEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUZ6</accession>
    <name>A0A9Q0LUZ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUZ6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10267" checksum="AEA475D9824F855F" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKKGIKITKEIIDEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVI7</accession>
    <name>A0A9Q0LVI7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytoplasmic protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000031">
        <property type="protein sequence ID" value="KAJ5079495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVI7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="156" mass="18457" checksum="47566F66FC1C3B0F" modified="2023-09-13" version="1">MLSRIIPTKPIKTQTKTIFINKIERLMHEEYKLRKKQKEMKDRKEIEEVIEKSKVCRLGLSVENKPYNSYVCFEFDSNVKIVEETLPCHWTCHFESVIGYGHVSFVEDVDEKKKAMDIIMKQYGWESKSNLYDPQSFKVAKVFKLKIDSITGKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWI2</accession>
    <name>A0A9Q0LWI2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-coupled receptor gpr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000048">
        <property type="protein sequence ID" value="KAJ5078713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWI2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="124" mass="13697" checksum="A804CE602C60F23C" modified="2023-09-13" version="1">MSIHHQSIHQSINHHQSTNQPINQSQPNPINQSPINQSSSINQSPQPIQSIGQLPINQSINSINQPITNQSTNQCQSPITNTTTNQSINQSINPNHHNQSINQSINQSINQSINQSSINQSINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX10</accession>
    <name>A0A9Q0LX10_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX10"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="356"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="689" mass="80612" checksum="D80E7C068D345424" modified="2023-09-13" version="1">MSKKNDHQFLNPFLKYITNTHSKLLNTHKHYITIFCPESSQLENITFTTQFVQTHIVIQNRGEKTFVTLSGIRGVVCLKDSFNLQFDRVHILPTTQQERELNLKLIKKKKYSTLLKFTPDQVDSHFLRSDPIIVRSGEFTFKKNLFPLILITNILNTNPQSSNISEIIQNKNIKRTGSTPTFVSNSLSPKRAQSFHQNIPNPSHLNRTKNIDINNNNNNNNNNNNNNNNNNNSSPNSPRSYYPQINEDLQNKTSLKNVYYDNLINMLDEDGQSIIVQLNRYIFSLDKEIQKLGTVEIAAKNQQICKDLSNQNIELTSSRLSSKSKEEIDRFEEVVENIICFHFHDILFAKIKDLIQEQNSKLNESVSRFQNLLESMTFLEFPDFIQKSTEQIKSAKEELVQINELRTPRRKLHRLSKIFDILGKAVLNYVPFLCPFHLHDILVYLLVYSQVDDIYSNILYIRKFSLMETLLQPQTEFVLRNLESACDDIIELDENSNQNIKNSNRNIENIKNIENEKNIENEKNIENKNSKEFLSVKQTIEHLQKFPENEDIQSKGINFILNSLQHNQKLNQNSYKQFIENNGMQFLTSLMDKFQTNLSIQKNGIQIFQEVLNQNGNENGNENENEIIDLIIQKNIQISQSTNFKFSNVSIQNLKFKEIQNFVDELHQLIEQNEMMNKFFIEFRENIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXN0</accession>
    <name>A0A9Q0LXN0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000003">
        <property type="protein sequence ID" value="KAJ5080722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXN0"/>
    <dbReference type="OMA" id="HYDIKGY"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="542"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="838" mass="93548" checksum="5E71A5808B7E1389" modified="2023-09-13" version="1">MTDQNILLGEENKYQGEETIEITDKDGIKDPEKPKALPICSKPLRVVGVQEKSPVSWSPDGNMFAFVSGNHSIYLIRKNERKSQQGTIALSFSVEATLEDHVSPVTSLLFHPNKPILVSGGHEGLFIWDLRNSTLKQKIKTGSHISAHDGAVECLIWLQNGDCLITGSSDTTLKAWDMRGDQAQCIDTINAHKAPILVFTYCPATQILASAGRDSTIKLWDISKLNHFFTADEHEKDDTSVKIVQNNSIEGHRGDITALTFTRDGSRIWSGARDNDIILWSTKSAKKVDSISGHKGDIKKLLLMKNETVLISASADKTIKVWELSSKGDKEEKTEKTETRGDGGLEDVLQTVDNEALRKILEDDISLTTLIKDQLEGGAHLLNELEAHEEGIASLEMSPTAPLGITSSMHNSIRIWSFVNPLKIGFVHEFIGQSKAITSIRLDERADDDDLNENNQDQNRETALRTIFSGSLDYTVHQYDVETVGRLMQINFRNSVQSLDVSPDKQFLVIGGSSYDLKGYALHPSYVKDNDATCVLQEVARFVGHSGKIKYIAISPDGNMMTSSSNDFKLLTWKLKKPYSPKRMTRGELLTQSDFDVNSFDFKPGVQHVLVPEKIKPTDTVHEHEGHVNCFGFNSNATLFASCGNDHKIVVYKPNTRKAGLSKKFAQSNAHNAVIECMCWCKDFQSNKELLCTGSWDKTAKIWRIDDNQKGMKCVRTITDHWGKIVGIGASGDNRFLLTCSVDFTVRCFSLTEPFDCVALYSIPQEAPFTCLAVGKDSFVTGSENGMLRVWPMFGGRFDNSFIQKIPLNEQIEYDRKLAAIQSERRRKAKKVDRTQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXQ8</accession>
    <name>A0A9Q0LXQ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXQ8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="397"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="489"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="69198" checksum="7413D411B9A6D7DA" modified="2023-09-13" version="1">MNDCLFFGRNKNSILIKNKPDSIAKPTQFKFENENENENENEKEIKQISSGLYSTIFLFENGKAIEYLKENDSNQNPEKIQIEENIQKVTVGYANEAILTIEGNVFAKGYDINPNNPNKFINISSLIEDKNDKIIQDVISGIYSIYLLTSNQNAYGIGSNQFGQLGFDSETLQETEKPILMMKNVSKIFSGNSSDSVFLLNPNQELFGCGYNQYVQLGLGELVKETKIQKLTKIQNIPKGKIIDIQCGFYHSIMLIENENENQNENPKRKLYSCGHYQYNGLDTNVYEFTEIKSSLFENDDNIIDISCGDDYTLILTSKSKLIGFGSNYFGQLGNRNTINFQLIPIQIELPKLRFNENISNYHISCGYDKSFLYYSPPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNQNEIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKEIINEIEIGIDYFQINQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZ42</accession>
    <name>A0A9Q0LZ42_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000010">
        <property type="protein sequence ID" value="KAJ5080490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZ42"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="400" mass="49241" checksum="689AEB2520CF5715" modified="2023-09-13" version="1">MKKEIYLSETKLDEFCKQPKFKEYYCEDFCYVWNQYYLYKPNEKLILISPQTKLKEINETKEFLNIFEYFIQKYNKMIKILKQNFPSTNSQISYKKEIELIYEQEFPKILEIKKNEINSFIQENLIEEISSLHLIENFIQDQFKNIKFQKLQIKSTNFEEKGMKIEKEKLKQIKDKFEKNNFEQNKLSYKLRKDIIQELEHFRILPNSIYYLVILIEFLSKKEFKEEEEINKWKNLNIKTIITTKKIGKQIENQIPKFIHSILFGIIKDYIDECPNFANIKMNELIDLYKTLFKYFIDPCEKVDSKFKQHLSYQQKKEVIKFFEEESNILKNILENILRRIENLKIENDPEKENIFSFPDYALSQRLTEFFKELKLKYIIHLYRICYKIYQKKRRENNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5C9</accession>
    <name>A0A9Q0R5C9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5C9"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="397" mass="46515" checksum="7811D38476FED84C" modified="2023-09-13" version="1">MNGKTKMDFMERYSEFRNFMEKYSLEKAFPKEAPNLQLPKKKLLGKMKTEIIESRTEQLDTYIKSITSLKEISSSEIFLQFLSYTKPLPGEFIKVETKGQGPSPRTNAFIFFYSNSIYIYSGFDNKNRELNDFYNFNLNSKAWKKLDLVGEKIKEKIDFMIAHDNKLFLIPNFYSETVIVDMVDLTNKYITKIRTEGSIERRTFGSLIAVENIGFIFGGRSIVRNKDLGNLDILNLETLKFEKIKLENSFDNLEAPNAQLARVSLSGNLDEDQGVIDWNKNLHSTPQNYPKKHKKNFQNDFIILTTKSKSIYNKSRSSNKSNSRLENQENSNDSLSYETLFFYFHYKDRKYYPIVPKEEIQFQQPPSFIRVRDSLYFFGGIKPGNIFSNELWSFKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5M3</accession>
    <name>A0A9Q0R5M3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide exchange protein smcr8b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_13064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5M3"/>
    <dbReference type="OMA" id="QRDENME"/>
    <dbReference type="OrthoDB" id="2289278at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31334:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE PROTEIN SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31334">
        <property type="entry name" value="SMITH-MAGENIS SYNDROME REGION GENE 8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5067286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="894" mass="106709" checksum="DBBF45D1401B0C42" modified="2023-09-13" version="1">MITDFVVISEFCEKVGPIPIWIFPEEKFRNQTFNFTRFVLSVMSSNLHPSEKLTGNKDHEFVIPIPENEENLCAFVVLFSLFDRDARGFVRTLCISFISNRTKIMDNLVDLRASFLKIVSYLHSRNNPQFYFEIVQRINTLEQIEKNQIESKNYKKGIDIKLNESLEELQQSEKDIFSIISLQELSLLDSFLRRETKKSQDGNQEIRNNYSIYKQFENQNEIEIEVENENNKNQIKNQNQNKNQNQIQNQNQNQNEIENQNQNQNQNQIQIQNQNEIENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQNQNQNEIQNQIQNQNQNQNQIQNQNQIQIQNQNEIENQNQIQNQNQNQNEIEIENQNENQIQIQNQIQNEKNQIQNQIQIQNEIQNQIQIQNEKNQNQNENQNQIQNQNQNENQNQNQNQNQIQNQNQIQNEKNQNQNQIQIQNEKNQIQNQIQNEKNEKNEKNQKNEKNQKNEKNQIVILKNKYKKSIHGMIQQKTQEELISYIKQKDYDFPLRPIEKVFIDEAYKNITQIHLKQFLHHFSKNQIQLFTEYHIHTWKDEKELLLTIGKIPILNFGTKFSKEKNQTKISNTEQFSSKNKSSASEFINNPHLSFDLFSFNTQDFRQSLDFIWRDDCKNGIIEFVHKKFFFCIEHLVYTLLIGRPLFITASSTHENFARYMVSHLTTFVPGEITKQNVGNIWLTSSQKSFQELVNMKICSISKAISLPKSLHKFVSIYDYETGALNGPLYYNLKKLKNKENNSTNIFERKQNHQKFSKSFVNKILRLDCQWNDDKTYLAHLYSAFFEIALHSWVYYSKSQNVKNFPNPKNQSKSKFSGSSFVYKKDLKIIQNFIRVIHFQKWKKATKGRKIFEPIHLNFEKLRKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5S1</accession>
    <name>A0A9Q0R5S1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5S1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040395386" description="Transmembrane protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="27087" checksum="2566D7A47E384DD8" modified="2023-09-13" version="1">MLLQFILLLSLFSLIFTCSQYSSCTSCVGDVSCYWCEDDDTCYNSDWEYSCSNWDYSKGGCPGYIATVVGSVIGTIVVVTIIIWCCIFCTRRQRRLRMYALNKNSLEKTPLAQQDRINQTPYIPIQPNYQSNYQSNLDSNFQPNFQPNFQPNYQPNFQPNFQPNFQPNFQPNFQPIYEPNQLNQPNQPIYEPNQLNQPNQPIYEQNQLNQPNQPIYEGPYNPFKPNEDSQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5T1</accession>
    <name>A0A9Q0R5T1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5T1"/>
    <dbReference type="OrthoDB" id="298084at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="302"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="481" mass="56854" checksum="CD8A9E860F21E434" modified="2023-09-13" version="1">MQNYSNLEKLSNDLQNLFQNQKDENYYDFEIICQFNQETNPISFKTHKSILSTRSQYFKSLFNSEMKDSQEKQMILKDISSQTLFSILNYFYSGKIELELQNAIEILFFSSKYLIDELIEISSDFIKSNFRIESIVDILKLSESMNFNQLMDSSYQFILENFDILIKTPFFLQLEENHLNSILVNDQIITNEFEIFQALIKWGKHKLNINQQKDNQRLDKQEKEQIQNQISNVIDKIRFIDFSPKELEGTLIENLIPNQISQTLLQFETLRNHQGNEMKLRELIQNQNSFIFKSRIGLQSSIIQTKEYFNRLKEWINDNEFFSKMNLGFSARRDGFYCKKWHDMCDNKGKTLVIIQTTANFIFGGFTKVGFKKGSDRYIKDSNAFIFSLRDYQNSRKPEKFSIKRNEEKHAIYYNLNYGPVFGGEGYGDIDLNSDLQPGRLSFGRSYNLPFGMKFGTNESKNYLAGSFDKWQVYELETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6D2</accession>
    <name>A0A9Q0R6D2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6D2"/>
    <dbReference type="OMA" id="VACIEDH"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="3 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="280" mass="32468" checksum="5E6798A3CF6C074C" modified="2023-09-13" version="1">MELTEEEKLRILSHFLLSSPPGEFSEVLTDVRVCLQDDDLLNQAALPCFKQFNHDQMIEAELTDLGYNVLITDYGESETDFNYYLDPRSGKYFEFDHLEKRFTGNIGKIQKSSDIRDAIDFELNDYCISYYPQGTVTVYEKPDKIIICISAFRFSPDNFWNGRWRSIWQLEGISKSKATLNGFLKVECHYYEDGNVQSTIEKQYTQEIDMGDQKSTATNVVQAIKELEQKFQQSLEEQYQIMGDTTFKSLRRKLPITGTKVEFANILAYRVTSEMSGDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R744</accession>
    <name>A0A9Q0R744_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="1553"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1345"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="496"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1181"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1218"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1345"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5069639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1927" mass="224850" checksum="F65862A696FB9909" modified="2023-09-13" version="1">MQHLLEGIQNEDISIKYNSIIELNEKICLATEKTFRGFSLEKFVPAIVNLIELPDSPEISLIASRTLTNLLETLPDSYHIISSLAIDVLLSKILSIEYLDLAEIAIDIIEKISRRTFKRILESGGMIALLQFIDFFPSITQEKALSAIANMAREIPQNSLDKVTEALPLIINQLESSNNKVVDLACLAIFRISKKIIFEPTFLTILSDSNLLKNMVNLLIKESQNTGTIKSTTFASVASFINDLCSINPSIVKILFEMDLYNILKKILIGDSSQNQIEDQFIDNTNLANSPSKQMINIPYTRSTNQIFHIISLIEAQLPLIPQNVISKEIWDIIQEENEIKSEIHSNILDLKQAENLQAAHIELITTSPEIPENLAANLLEPLIITFTNSVAPALKRKCLVSLFKMIHFNSQEKLKQLALPLLNSFSTLISELITQRKDHIQIGFGILLSHLFCEKLPEMFWNIFQRDGIFYECENLLSVTKEWIVSNEQSITDFKKGLEIQLENDKNEIEELRKEKENKENRKQELQQSFQKRKEEIEKEMEEFKSKNKDEESIIEANRQNEQEIKKLNQNITRISNQTKSIIRAISTKTRSISQVKEKLEKYTRVLEKSQMKKLDSMDQETNQNMDQEPINEDMKQDLFSDDQDETDIKDSFQEEKTRKLELFRILREKDQQFLLEHRDEIEQMVGELPRYGDENFSFSFSKPKELKRIEKPAPKDELIQKKIIDDWILFTTQIFLDKFFSDELKKKFGVQDLGLEKFKQLGKELVSDNNNSLAILKEIADIFRKHSKSTFEILQSGIIPSLIRYLTLPREIQDITSNTEDVELASKLLDNLEKFHSTFFYIPQEEKVIIENEQQDNQENFKERVPIIEMIRQLQEVLNKVEDFPSEVDPQFSFHLARKPLKIMFEKSPNEKTLKPLGNGFSTFDPLITTNILETIIWGKVRLPIDGSLPYIDPEILGFEEKQHNQLFEVDPDEVHLSDHPFYNRESFLDFNLISSSLGIIKQDPSYLDSNRYEDQYRPYSYFNQYSKGPFSMQSEDKFEDLFSIKSKFGEKNQEKAKIKKFMIRKKLKSLKKMKKKMNKEYQESDSISITSESISKSTSKSKSESKSKSKSKSKSKSSDDEFMLIEPIKKEPIKKDKIKKDKIKKEPIKKDKIKKDKTKKEKIKKKPIKKYHKKYHKKFDDKKEKKYVSPFLKEPKSKVEKKEQQIKMDEDDNQNSEQKALNSQEKQQEYISELEKYEKLFPINQNNHRYHALQLSYMGKKLDYNKGLFQQIFKIWRQNHEKGVVIGNLWKETIVIRYQRLYPFSERMVELMKVQEQNAQKMQIDSKKEILEKKNEAKIKIKNKNKNKNKNKSNKRKIEDNQENVAVNINNSNEKTQFYGTKVPEIIQILSDRKLRRLEFPDSDLRCLEALELLWILETINRLYSQEIESGKSVKASGVQVPQEEFISLRLTAKFTRQIEDPFILFCNAIPFWCTQMMHKGYQFMFPFEKRLRYFYATSNEPYHSMKQVISNTEKYAHQFRNIKLGRIPKFKVKVLRNRILDSAIRILNSPRGIGRSLLDVEYFGEAGFGSGPSQEFFYLVSRELRKKNLKIWHDSSFQKNKNEEKDEEEYVESPNGLFPRSIFSHDSQKIISNDEQNENQKIADTFEFIGKFVARAITDSRVTELPFSQAFFKAILGKELGFSDLQSLDPEFSKALKELSDISDQYKKTGNKNIMYKNAKFEDLFINFVLPGNDTELKPGGKDIFLNLDNIDEYIDLIIRARLKEGIYKQVASFVKGFNQIFPIKNLRVFSFEEFDVLLNGSVEQWDENLIRKNIKCAHGYTIESRVVGYLIQFMADMSPSQQRKFLRFITGSSRLPVGGIAKLNPLLTVVRLSVENMNPDNYLPSVMTCANYLKIPQYSSKEIFLQKFQIAISEGQSSFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7L2</accession>
    <name>A0A9Q0R7L2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7L2"/>
    <dbReference type="OMA" id="ALYGTWR"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="276"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="378" mass="43053" checksum="45540601C7EA2041" modified="2023-09-13" version="1">MCAAIRPLVTVHSLTKDKPNTQVNLPTVFSAPIRPDIVRFVHTNMAKNSRQPHSVSTKAGEQTSAKSWGTGRAVARIPRISGHGTGRSGQGAFGNMCRGGRMYSPKKIWRRWHRRINLNQRRFAVCSAIAATALPSIVMARGHVINKVSEIPLVCDNSIEEVKKTKEAVRILRRLQAYKDVEKAKASKHIRAGKGKMRNRRYRIRRGPLVIYAHNKGIKRAFRNLPGVETCKVTKLNLLQLAPGSHLGRFCIWSQDAFETLNKLYGDWGQESQLKKGYHLPRPIMTNTDLTRIINSEEIQSVLRPKIPKPQPQPQRKNPLKHKDVMYELNPYAKTRKENQLALLNNKSKDNSQIPKLSTEEKKRRKSISKKFYQSLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R891</accession>
    <name>A0A9Q0R891_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R891"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="459"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="511"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="841" mass="96415" checksum="C3430699AF692E1A" modified="2023-09-13" version="1">MEDIETLVIDNGSGMIKAGFAGDDAPRAVFPTIIGKPKYLAVMVGMGHKYSYIGDEAQARRGLSNISYPIEHGIVRNWEDMEKIWHHTFYNELRVAPEEHPLLITEHPFNPKRNREKMTQIMFETFNIPAFYVAIPGILSAFASGRNTTINIELGDGVFYAFPNSSSFASLHSITRMNFGGRDITDYLMDLLTENGLFFETTGDRETVRDIKEKLCYVAYDFDEEIQISSENSSIEKSYELQDGQLITLGDQRFRCAEALFQPKLIGRENKGIHQMIFDTISKTDIDLQSLLFNNIYLTGGTSMFPGIADRIQKEISKLAPNVKVNVLAVPERKYSVWIGGSILGSLSTFQDKWISKEEYEDVGPTISHSKSIEYLNENDSNKNPEKIQIENIQKVTVGNRNEAILTIEGNVFAKGNDINPKNPNKFINISSLIEDKNDRIIQDIVSGNSSIYLLTSNQNVYGIGSNDNGQLGFDSETLPKTEKPILMMKNVSKIFSGNSSIHVFLLNSNQELFGCGWNRHGQLGLGESRKEETEIQKLTKIQNIPKGKIIDIQCGYIHSIMLIENENQNQNQNPKRKLYSCGDYQYNGLGKYENTYEFTEIKSSLFENDENIIDFSVGFDHTLILTSKRKLIAFGHNFYGELGTGTTSLNQYIPIQIELPKLKFNENISNYHLSCGFRKSFLYYSPFLSPFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNENQIEKLQEIISSKSIKESNQIFEMIYSNRIINPILYSEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8F3</accession>
    <name>A0A9Q0R8F3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8F3"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="489"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="69751" checksum="CAFB3A9565D257D9" modified="2023-09-13" version="1">MNDCLFFGQNEEPKLIKNETEKITKPIQFKFENENENENKKQIKQISTSYFGTIFLFKNGKAIEYLNEEYSKQNPEKIQIENIQKVTVGFQNEAILTKEGNVFAKGKYINPNNPKEFINISSLIEDKNDRIIQDIVCSYNSIYLLTSNHNVYGIGSNYFGQLGLDSETLEKTEKPILMMKNVSKIFSGNSSNCVFLLNSNQELFGCGYNQYGQLGLGKVERKETKIPKLTKIQNIPKGKIIDIQSGFYHSIMLIENENQNQNENPKRKIYSCGYSPYNGLGKNEYENTYEFTEIKSSLFENDNDILDFSVGYVYTLILTYKGKLIVFGDNTYGQLGTGDTYDEYYPNQIELPKLRFNENISNYHISCGYSKSFLYYSFSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIKITQEIIEEIETGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8N8</accession>
    <name>A0A9Q0R8N8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Villin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28894at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF51">
        <property type="entry name" value="PROTEIN FLIGHTLESS-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="3">
        <location>
            <begin position="1443"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1506" mass="177797" checksum="F3F465850CC901AE" modified="2023-09-13" version="1">MGNSIEIQFVAPSDSISQTTNPHYKKKIFFSKNINTGEFISFSQFDSKKQEKQQEKFFTHQEIDDIYEENEKIFNSIKQEFNNLKEPIQPNLTQKKKKKTEQIIPKKTEQIIPKKTEQIIPKKTEQIIPKKTEQKSPNKRRTKNKTKTKNKKENYDMNTFVVKDINKEQEEIIQEKQKKLQQSPQTSKMFSQLNQELVNSQKTQNKISKLQNQSQENIKPKKEPKKNVLSQQRIEQEKKRERLKKEQEQLQRQLSQIREEKNILSRKGSVVEDKKIEEDKKLKKIKIEEDKKIEEDKKIEEDKKLKKIIKLKEDNKIKEDKKIEEDKKIEEDNKIEKDNKIKEDNKIEEDKKIEENKKIEEDKKIEEDKKIKEDNKIKEDKKIKEDNKIKEDNKIEKDNKIESKIITSKSIKEKDPKITSTKKYEHKSRDHSKDKTESRSHYYGHHGHYHSRHDKHDQHNKNDKNIQRSKDDKNVQHNKDDKHYQRSKDDKHYHRDKNDRYDRHGHYHHSHHRNIKIEDNKIEDNKIEDNKIEDKKIEDNKIEDNKIEDNIKEDNKIENDIKIEDDEFIPDDFTDEDDEDKEITQKEKEKEEEKEKEEEKENKNQIQQNIIEKYFEKSIQKSIQQIESQSESESEDDDESFLKLSFTQRAKLFQKKFQKTQQKTQEEPKKKTVEKRKLVHLKKKVPRRKGIRKQTKDPAQQIETVDLRELAQKKEENQENQNNSNNNQENVAKEIPKQVQTPQMMIAQELTKAIQKKDQKKEKQSKFEDNYLSSVKKPEQTKTPQLYSIKGFRNPRVTLVSPQISSLSQDGSFVLDDNKNKIFLWHGKTVGRIAKSKALHFAQNLKAKQHGGKPDIVVMEEAERGTQAFWTILGGTADNIRGSSGQTPQEYEREWIAACEVNLVRQSRLESIVKGRLPVIEILNTEHVFIISTPSGVFLWTGKSSPFADRKYAIKTADEICKQKYPDWMSVSRNIETGEDSLFKEQFSNWPDRLPISVSKHEYVRNIAVVDQQEAEKGPDLTDLIKNSDPNNAKGIHLQELLPDDGSGSKKIWRIDNYQKVAIPEIEYGIFYSGESYIVHYHYISERKKEYHTLFFWQGRDCPINEKGASALLTIEFDRAEFQGEAKQIRVVQGHETQHFYLLFNANLIVRKGEDPRGSNFRPQSAPNFPALFEIRSRRDMNRKLKKELNISLVEDPVLNREQRQTLAVQIDPEPDLLNPFSDFALQSKTSIYLWRGKSVSQEDHDAAKNYICPILQPENTSVVEVSQGKEPNDFFKCFSEEKNLKEKEVKKIISTNPTFKLTEKLSDHPFSPCLFFCGIRNGLFAIDQVLLLQDSLDYMNCMILDLHFCIFCWVGPGASDDVQKQTFNTALRYWKETPKSRPNPKNADLPIYRVLAGQEPFEFSSCFIGWDNSIKFTHPRFSLKKRNPISFKDIETVQSILKKYQQTYTIEQLRANPKPPGLDYKKLENYLSDQDFESLFRMSRKQFQTLPQWKQHNEKKRVNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8S3</accession>
    <name>A0A9Q0R8S3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8S3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="213" mass="25220" checksum="DEE8755EF9CB598B" modified="2023-09-13" version="1">MENNKSFDYDLRIGIFGAGGVGKSSITIKFTHNMFIEEYDPNVEDEYTKEIELNDKKILLKVLDTTYPQEIYDPFPRWVEYSQVFVLIYSIIDKYSFDEILNYHNYSIKKIRKDYPKILIGNKSDLTMKREISIKQGKELARNLNCKYIETSAKTGENINQLFYESSLLAFEELKNKENQKSKSKSKSKSNEKEKRKMFINVKIIYFKTIYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9Y3</accession>
    <name>A0A9Q0R9Y3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="RPFELWE"/>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057852">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057854">
        <property type="entry name" value="TPR_WDR11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23751">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23752">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23753">
        <property type="entry name" value="TPR_WDR11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR11 first beta-propeller" evidence="3">
        <location>
            <begin position="16"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="4">
        <location>
            <begin position="403"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 TPR" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1287"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="821"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1289"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1314" mass="153186" checksum="32876ACDE30F6553" modified="2023-09-13" version="1">MNKDFHKIIPGILDNQNTHAIDWGKNALLSYGCQNIVVVLDPESLSVLQALDGHKAFVTAVCWSQECFPKENDKTFYLKLASGDSAGNIIIWEPKRAKALFILSNETLRNKSVIQINWILDNHNQSILSFHSPSKIVLWNLPNKISKTSDPQAGSIKWELDLPFTLTSIAINPFNDKKFALCSSTDWLYLLKDFNSNKKPIKIAKKYQLITTTPKKETDQKKGKEESRNVKQLIYSNEKKDILYFIFEREIMVVDCTFDLVIGSARITDSDQPLCKMKFSNLHPNIFYCLHEDGSISQWEHHFDSDSVHFKKINMANQTRLSKGLRNRNSSNIGFCKSPYSNDAFIVITIDGRIWKWKADSKIDPILITQRKTLNTIKLIGHTETISSQVTSLSSCTFSKESNLIAVGTIDGILQILDYKKGAVQSSYYVFQNPIIGLNWINSNIVVAFTYSEISPNSYFNQIIMIDIISGRQKLIKEEIIEKDYITAIHVAYSSNLITIMFNQKPFEIWSLETFCPLQTISPNNVVDFKWIFDDSQEKQRFIFVVKGEGIIYRYYVEGLKISKEAHINFGNGIGQITNIAYKSNTFVIGTNSGIIHYININVKKTISIQTGQKRTKKMEFFPFDSQILLYILFENDEFAIFDLVKNRRVGGVHKKKPDQGVFIAWTPRKNGTVFIYDLTMKKVETRIHYRRLDEKPQTPFLFTLRQASRLKLWMKFGMRKNLNKKLNENQENEKNDNIYENKEFFSIIQDDPDLIQKEILEEIDGIPDVIYQTIKKSGTAKRCLVTANYFADNYEEEFWSLALFYLDYFASHKDLLPKKEDDLNNQIEKKEDDLNIQIEKKEDNLNNQIDKKEDDLNNQIEKKEDDLKNQIDNKEDDLNNQIDKKDDLKNQIDNKEDNLNNQIDKKEDDLKNQIDKKEDNLKNQIDNKEDNLNIQIENIQTETIQIESIEIENIEIEKNQNELKQNEKIIELFSQHVQPLNPNKIKLTGKFADLRSREDIIESSEEIRIIKDVHRKDSYSLTQNVMNDNLFLNHKKEAIDLLFETPKDHQNYFQDLLKAAIISATVSQEHFSETICKIADSLMAEKRNSEAIQIYMMVGDYEHACQALQKVGMWGKAYLFSKMHLPQEMHFKFTLKYGEHLVKVNRILEAIHVFITIGEFKKVFELLLQMKMFDTAFFFLMACHEFGLSHLKQIDEEQKQNQKNQRLNIDEMLQKISLSNEESKIEDGNIILAPHQVWELFPFLEFCSLDSVIYDSFMNHLKDLKFVSFQNDFAFLTGLEIIEDEKEDKDKKDKDKKDKDEKDKDEKEEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAD4</accession>
    <name>A0A9Q0RAD4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Apyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the apyrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAD4"/>
    <dbReference type="OMA" id="EDEHKGT"/>
    <dbReference type="OrthoDB" id="25028at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.100:FF:000001">
        <property type="entry name" value="Soluble calcium-activated nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
        <property type="entry name" value="Apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036258">
        <property type="entry name" value="Apyrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06079">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101887">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR609283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="345" mass="40167" checksum="05A8FF655E0C2C32" modified="2023-09-13" version="1">MNPIIFAKYQWKNNKKGIVVIFTILLFFSIVFLYSGKPISAFTEEAKDTYRIAIISDPDTDSKIDEYKWESILKTGYLKRNKDKTYTLLWEKQINLTTRHSESGRGMELSELIMFEGKLLAFDDRTGIVYEIKDDQAFPRYILADGDGNNNKGFKCEWATVKNRQLYVGSIGKEYVSDGKILHYNPMWIKIIDKKGKISHVDWKEQYNVIRGATNSLYPSYQIHEAVNWNPTHQKWFFLPRKISHQPYDEVIDEMKGSNKLISVNEKFKDIEVIEVGEVNESRGFSSFKFIPGRPNEIIALKTQEVNGEVGSWILVFDIESKKFLLPETYIDEMKFEGVEFIPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAG1</accession>
    <name>A0A9Q0RAG1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAG1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="483"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="586" mass="68806" checksum="761371E5AFB01BD3" modified="2023-09-13" version="1">MNECLFFGLNRYPKLFKNEKDRITKPIQFKFENENENENEKQIKQISSDYFSTIFLFKNEKAIEYSRNSRENPQKIQIDENIQKVTVGWQNEAILTKEGNVFAKGKNINPKNPNRFINISSLIEDKNDRIIEDIVSGYFSIYLLTSNQNAYGIGDNHFSQIAFKSNNKKKRKSEKPILMMKNVSKIFSGNNSLFVFLLNSNQELFGCGKNNHGTLGLGYRKKEILQPIQIKNIPKGKIIDIQCGYFHSIMLIGDENGKIKFYSCGNYEYNGLGKENENTYEFTEIKSSLFENDDNILDFSVGYSHTLILTSNSKLIGFGNNSFGQLGIEETKYQPIPIQIELPKLRFNENISNYHIYCGYFNSFLYYSPPSLSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNENQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNEKENEKDFIIERKEKQHKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIKITQEIIDELEIGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBD9</accession>
    <name>A0A9Q0RBD9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lysosomal cobalamin transporter-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_00694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBD9"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5074066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="473" mass="55018" checksum="309799B122117574" modified="2023-09-13" version="1">MTAVWLLHVLFSLFSFGLVWFIIRYYSDKLETENLQKVISIFGLFVIQIILWAIPIDIYYGNISEKSTMASFYYGFFVIIFFIIFLFLPMGFFYYNDINLNKKDRIIKALKLSLFISIIGLIVFIIGFWMNRKNPDVDPWMKEIFTQRSPVHFAAEFLIGVLAIFGIIQFLKYTIYGLSMLPISLIKGKQDITIENSQIESQIVIAREKRRIIETKYYALDTPVTKRDQKEIESLKRKERNLERAKNKINEDQQKFLSKVIRFCNPMRKFFGFVFLLFSLFLVISVLLSLIYKITSSSCGSNCGFILNGPTKNPFDLLMVNLSKAFPLDYFVFVAIIVYFIIISLSGMAKIGLRFLWVEISRLRKKSTVPEILILMIATLILIGITMIFEFFYFAPQWATFGSQKNEKGELCSITDIPNCKISGIAIFVYRILSNSFFSVWIWISNLIFVVLYTLILVISLKKPASSNFEYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBN5</accession>
    <name>A0A9Q0RBN5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ran-binding protein m</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="825"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1640" mass="191343" checksum="A975D48EACD7FD7F" modified="2023-09-13" version="1">MKLKLKLKFIYKIKIKFNIEKQFTVITVLVAIFAVLFAALKYLYQLHSQSKQNPLIIAPVLLIGAWYVCFAIWSLLESFDSNAFNESILKYSLSFAVVFLFFGPFVIFCPTRPIKIDKDKLFQAVKAGQDAPKKKKNILGMIVLFFIVILQGFIFYAIFYSTYYVFEVNIALVIGSIAGYLFAMIIYLVFFASVLLDKDIYIKGANMMDELRGKLIINRINAEPLNILASGFYSKIYLILFFPLTCVILYMLLRIFIVDMNKFSDLATGAKSISIIFFSIILLITIYLIVRIIHFGIKKVRVYSEVQLEDGKIINLNTIKYISVVRSFDRITLCSYGSRSDPLIPKFTQIVASRQKVTPTTPGFFSRLPIDHLWCLIQENDYFSMFFVVTGNSYEMNTSRHLISQIQNFFQNTFYEEVAEISFPKQKVKRNSDGYFQLEYKQTPYNLYPPFGLNYQVYEFFMHLSRKYSDPTQYSSLVKDAEKWFNENANLQLDYKNYYQTQDNELAKVDENQKEIIVDLEEKLSKLSTSIEQEKQDPEFKPPDSTEKRKSIPNEEMKEFEQLFHRPIKQFEPVVDPKNKPNENDPLIPDQAPKPIVKPKGKKKTKEEKLIEKQKKLEEEKIQKQKIKKSQEIERKQFLQQKEHELKIQKEQQMSERLKQRREFQESLITTSFKDFDGDFEPIIFEDEDDLDENEKTKDDLDENDLDKEKEKEIQIESESESEKEPKIDKLKLSDPQDRFAIDELIKRVEALEPHLNSLKMIKIDRKDLSPDLKITEIKPNEYEIILKPKTPPMIQQIEPQPTEFAFEEPPKIPKNKKLQEPPKRPKITSENVPFSLAQQIIVPRPEKLHKNKHKNHYQISDDRREVQYTMVRGEGVNDYDLGVIFRGNLHVADPLPVYYFETKIVSGGERGEIAIGFYPTEKGKEPIGMPGWLNGSYGYHGDDGSKFCEADGGEGEMFSEPFGKNDVIGCGWNITYGIIFYTKNGRILGNAFTNVKNKKGFYPVVGLLSVGASVRVNFGQEPFLFNKFESLVPKIENILIFFDVQQRDYEEKQKEYEKLLSLMFPSQMDKFEKRIQSWVKSQSAIWQDNATKWILWFSSQLSQYLDKDGLKQFTKFHKQNFLVFSSQWKDQMAMHMRDIRDQRITILDRDQWVFSIKNTLYFFHNNWKMQINNHFSQIKSQSQQELFSWKSFTTRTPAPEHSLFVVEMQILLTSENKKSSENYKLFLESTQQANTGEQEQLNPEIAIGFVPEEYYFPNTTPGSTLFSTGYYSSDGSKKNAGVKTAFAEKFSFGDTISACIDTNTNTIMFAKNGHYVGTAARWWEKSIHKTDQEEISLDDDENQQPHKDQNNENNNNNSNSAEENTNDQDPNNLQSHAPQSTIPPDLSFLPVVAILTPDIKIRIKFNDFLSFPKAFGEYRLTPFISYDAYSLYKELYSVVLKPYLEKFQDGQPWRYELNPFIFQLFDVGIHHLFNLFSKFDRLISIQLSGKFPLEPESQLLILDWIKLSKTAIRQKSTELRLSQFLHLPLDKLRDSAGNTNENSIVSLVDTFRTFDSLFSVFEWISFPKFHQAIGFIFESLENSIRKDLPFFSDNESGLFLFKDFCLVFYENLIKMMNPKEIPEVQSLIKQNKKKHVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC83</accession>
    <name>A0A9Q0RC83_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fibronectin type iii domain-containing 3ba-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443915at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF173">
        <property type="entry name" value="FRAZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="142"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="260"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="348"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="436"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="524"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="612"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="700"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="788"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="876"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="964"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1052"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1140"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1228"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1316"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="948"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1300"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1398" mass="164252" checksum="907C44EAAF427A60" modified="2023-09-13" version="1">MSRSTKDIYNEKDITKLPQWIQTQIRVFTRWCNLHLQKRNLQIEDARTDFASGVILINLMEILAIKKCPQRYSPRPRVYAQKLENCKIGIDFVDSERLPKEPRLVNVGGEDLIKENLKIILGLIWILIRRYQISQGDDSETNSTQKMMLEWILSRINDFGVQIRNLTDDLNDGIALCCLVEKQKPGNIQISQLSKDNAQENLGLAFDKANELMEIPKLLEPKDLLTDSIDALSVLTYLSYFRNYSLNNPDEIKREFEDKKPEKIEEIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIGESEKPKFIIENIKPSTNYSIRIRAKNSKGEAEWSNEIKTKTEDKEPEKIREIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIGESEKPKFIIENLKPSENYSIRIRAKNSKGEAEWSDEIKTKTDDKEPEKIREIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIGESEKPKFIIENIKPSTNYSIRIRAKNSKGEGEWSDEIKTKTKNKKPEKIREIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIGESEKPEFIIENIKPSENYSIRIRAKNSKGEAEWSDEIKTKTDDKEPEKIEEIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIAESEKPEFIIENIKPSTYYSIRIRAKNSKGEGEWSDEIKTKTKNKKPEKIREIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIGESEKPEFIIENLKPSTNYSIRIRAKNSKGESEWSDEIKTKTDDKEPEKIEEIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIGESEKPEFIIENIKPSTNYSIRIRAKNSKGEAEWSNEIKTKTEDKKPEKIEEIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIAESKKPKFIIENLKPSTNYSIRIRAKNSKGEAEWSDEIKTKTDDKEPEKIREIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIGESEKPEFIIENIKPSTNYSIRIRAKNSKGEAEWSDEIKTKTDDKKPEKIREIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIAESEKPEFIIENIKPSENYSIRIRAKNSKGEGEWSNEIKTKTDDKEPEKIEEIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIGESKKPKFIIENIKPSENYSIRIRAKNSKGEAEWSNEIKTKTEDKKPEKIEEIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIAESKKPKFIIENLKPSTNYSIRIRAKNSKGEAEWSDEIKTKTDDKEPEKIREIEVEPKLNEIELKWKEPKNEGSEIEKYEIEVNNEIIGESKKPKFIIENIKPSENYSIRIRAKNSKGEAEWSDEIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCA8</accession>
    <name>A0A9Q0RCA8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040177743" description="Fibronectin type-III domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1700"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="472"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="1311"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1750" mass="198600" checksum="639E8C2AAFF1568B" modified="2023-09-13" version="1">MKLNLFFSFSFFLIINIFLIQSNQNQNQNQQNSISTIIQELETTRLLTETTRYYSTPDEAWIWNLLDQFSGSGYFGWIVSIYKDVLVIGAFGANQAYIYRYNGTIWNQEQVLDGPSASNFGNSVSIYEDVIVIGAFGANKAYIYRYNGSIWNQEQILNGPSASYFGNSVSIYEDVIVIGARDARKAFIYRYNGTIWNQEENFYEPSVSYFGWSVSIYKDVIVIGTDYTSQAFIYRYNESIWNREENFYEPSSSNFGYSVSIYEDVIVIGTLYARKVFIYRYNGTNWNEEQVLGEPSYSTFGCSVSIYEDVIVIGATDERKAFIYRYNESIWNQEKMLSESASQFGYSVSIYENFTVIGAYVANKAFVYEGSFIPQVNIVNCSSLFSLFDCYWDKIQSSLTLKYQINYGYDWIDIDSPILEDGNVYYQQFNSSIYDNITGNEYYSIQIKACDNVTMKCGESSSFINLTTKIDSVKDFQLSNPSNYSINVTWDYPNVQINEGIAHLNHYNLSYFIQSQPDLISFISVDNSSLDYFLNNLECENDYNISICGCRTQECEGDDKGEIVESSISLLFGEITNLTCSISNSIDINCNWNQPINCSIPFYYNLTYQSIYQNDSGNYQPTSSNQQFTVQFPNQEYQINISACNSNGKCGYISSISIKTDNLTSPIIYETISKIEEIEFNFTKLTNANNYSISLNNETNWEKFTSLDLSGNEGIGIISGISGNIEYNISIRGCSDLNCETPYLGLPSSIISTRTKLGNITSLICNSLINGFECNWDSLILSSGLKAYSFTYNSTSICLTNLTTNYSVSSGLNEGEYYEISIYSSADLNCSFNEYSGINSTTSITISTTNEPNNNSKTTAITLDQNQDQQNSISTIIQELETTRLLTETTRYYSTPDEAWIWNLLNQFSGSGYFGDSVSIYEDVLVIGAFGANQAYIYRYNESIWNEEQILSEPSASYFGNSVSIYKDVIVIGADYASKTYIYRYNESIWNQEQVLDEPSITFFGNSVSIYKDVIVIGTYSDARKAFIYRYNGTIWNEEQVLSEPSIPYFGDSVSIYKDVIVIGTYYARKAFIYRYNESIWNQEQNLNKPSASYFGWSVSIYKDVIVIGDYAAKKVFIYRYNESIWNEEQILNQSATYFGYSVSIYEDVIVIGARYANKAYIYRYNESIWNEEKFLSESATNFGNSVSIYGNFTVIGTYVANQVFVYEGSFIPQVNIVNCSSLFSLFDCYWDKIQSSLTLKYQINYGYDWIDIDSPILEDGNVYYQQFNSSIYDNITGNEYYSIQIKACDNVTMKCGESSSFINLITKIDSVKDFQLSNPSNNSINVTWNYPNVQINEGIAHLNHYNLSYIIQSQPDLISFISVDNSSLDYFLNNLECENDYNISICGCRTQECEGDDKGEIVESSISLLFGEITNLTCSISNSIDINCNWNQPINCSIPFYYNLTYQSIYQNDSGNYQSTSSNQQFTVQIPNQEYQINISACNSNGKCGYISSISIKTDNLTSPIIYETISKIEEIEFNFTKLTNANNYSISLDNETNWGKFTSLDLSGNEVIGIISGISGNIEYNISIRGCSDLNCETPYLGLPSSIISTRAKLGNITSLNCNSIINGFECNWNSLILSSGLKAYSFTYNSTSICLTNLTTNYSVSSGLNEGEYYEISIYSSADLNCSFNEYSGINSSTSITILTINEPNNNSKITSISLGIIIPIIVISIIIIGIILYKKKKRRKQIIKEIIKENEEEQELQDNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCM8</accession>
    <name>A0A9Q0RCM8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCM8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="441"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="615" mass="73781" checksum="BAC089D10742B30D" modified="2023-09-13" version="1">MDNNNNNNQIQNANQNENQNENENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLLQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNSNEIEIKCFELINQNFSQIKNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNQRLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDIFPKSFLVDIQNKVIQDNQKEIEDKEKEIENKEKWKKEVENKEKEIENKNKEIEDKNKEIEDKNKEIEDKWKKEVEKNQKENQQMKIEIEEKWKKEIEDKNKEIEDKNKEIEEKWKKEVEEKDKENKDMKQVFDRYQEKYQKYLEFEKKLEPIKKNFPQFSETRIITEEEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKQNFIFGGFTQVGFKSNYSGEINDSSAFIFSLRNDKGDRIPEKFTYKQGRAIFSRSDVGPLFGDGYDFCLSSNLQPGYSQFGYSYNLPNGIKEGTNEAYSYLAGSYSSWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCP4</accession>
    <name>A0A9Q0RCP4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCP4"/>
    <dbReference type="OMA" id="HINNDSF"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="304"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="496" mass="58244" checksum="5C0B867FB512606A" modified="2023-09-13" version="1">MKSTYRNIAKLQDDFTNLFQIQDEFSDFKIIIEDPKNPNEEKIFYTHRSILNCRSDYFQALFRSKMKEYQEGKILFKNISSNIMEKILGFIYTGSLQVTNEDAVEILVLAKKFFFPEIVNFLADFIAESIDVSNVADLLQISNQFDSPELHVHCINFLIKNFQEFLDSQNFKYLSQQDILNVLDAPNLRVISESTLFYSVLSWGKYQENIQSENHELTQEEKEILSRKIASCIEKIRLCDIDMKELETIDGLNVVSSQVISDLKTFHFLRSDFKFFSDYEKMKLDAMQKGINIFTTRSTFPKGTIFINREWELWLKKHINNDSFFQAMEMGFSTTQDGFSCSKFHLNCDRKSPILVVIQTENNCIFGGFSNVGWNTLRSYNYFISDPNAFCFSLKRIDSQEPVLFPIRKNEKSKAIYYHEEWGPSFGKDVAVYRDLRSGECYDFGNTYKIPSEIKDDSKKIREFLCGSPFWKVKFIDVYFDSSSEKKDNPYNSYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCS7</accession>
    <name>A0A9Q0RCS7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase a-2-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCS7"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="419"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="521" mass="60736" checksum="2725C1AFCE3CA0CB" modified="2023-09-13" version="1">MATEEKSTSEIIQKETEMDQVPIDRTPTSIIHGHNSKIRCFFVDDEFIYSGSFGKQIMKYRVSDSIKVWTKETPSYIFYLKTHLGDLYSSGSDIRCFNAQNGELIWSFKGDWDGYIFTFVIHNNKFYTGGKDTYIREYNFKKDGLSYISKQKNAGRVWSLEIFNDMLYSGFSDGNVKEWNLNSGLRLNRTIKCHSLGVWCIEMYEGKMITCSKDCSIKKWDINAGKELEKWEGHKQPIISSHIYNNILFTGGDGGTGFAWDLKTGKCLHKFEAEVKIWAVGATKQRLYLGTTTKKIFEYDISNLFRQKSLIKDLDQLYLRHENCDLEIATLGGKIPIHTQFVNFRLRIKDIQAYNGFFRYKKHEDVDNFFEWVYTGVSFHLRTIQEMIREMGQNQFDSINGIENLKHDLEALYHNEDSKDFTIISESKPIKVHKIILMARSDLYRGMFLSVNDDSNKVNDYSGKQFKTVNALVRYLYFDKLDNDLDNSVINELLDAESYYQLSENSNLSTEIQRLKSGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD56</accession>
    <name>A0A9Q0RD56_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD56"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="486"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="606" mass="70574" checksum="5AE9A980E35C0A21" modified="2023-09-13" version="1">MNDCLFFGLNYNPKLIRNEPDKITKPIQFKFENENENEKQIKQISPIYDSVVFLFENGKAIQCFTDSIINPETIKKKIQIEENIQKVTVGFHNVAILTIEGNVFAKGYNINPENPNEFINISSLIEDVNDRIIQDIVSASRSIYLLTTNQNAYGIGSNDYGQLGFDSETLFKTEKPILMMKNVSKIFSGNTSNFVFLLNSNQELFGCGYNSDGQLGLGESRKEEKNKLTKIQNIPKGKIIDIQSGNYHSIMLIENENPNQNENPKRKIYSCGNYLFNGLGKILKNTYEFTEIKSSLFENDDNILDFSVGNQHTLILTSNSKLIGLGNNSYGELGTGDTKDHKVPIQIELPKLRFNEDISNYHVNYGYNNSFIYYSPPSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNENQNEKLQEIISKKSIQESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVINDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKEIIDEIQIGIDYFQLNQTNPNLFDLLINKFKNENLKRKKNKKKENCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDI6</accession>
    <name>A0A9Q0RDI6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDI6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040188089" evidence="2">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="135" mass="15492" checksum="FBAD0C290961190C" modified="2023-09-13" version="1">METFNYFLLINLLLVFVFSKDCSNYLSKDDCINGNDQCDCGWYSCLFNGQIYTGYEWCLKGNENGVSSSVNPDTYLCPINSDGFNYFYNCDKGISNLGIGMIVVGCLIFVFVVVFIVIYIRKRRKTSKYMEIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDZ3</accession>
    <name>A0A9Q0RDZ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="EEIQFYG"/>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="45"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="216"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="219"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="659"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="831"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="917"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="1093"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1396"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="1398"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="1566"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1612"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1700"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="1842"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1883"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1926"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="2051"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="2094"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="2099"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="2180"/>
            <end position="2224"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="2325"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2484" mass="284584" checksum="D3247231B0CC1660" modified="2023-09-13" version="1">MSKKLSDEELLQILLQSLSQPNLNQQPNLNQQTNLNQQPNLNQQTNLNHQTSLNQPNLNQPNLNQQSNLNQQPNLNQLSSSQPNFIEFFPQEQNIFNPLNDIMGYQGMNETNYFLDQSQYQEINQIQEIIQEMNFFSNDPDAQSQSLDFLIDILQNDENHQTENQNEIKRLGGIETILKAMNNFLSYSDIQQKGCTALWASSFHNKEILSEIGRLGGIEIILKAINTFPNHLNIQIYGCRALGNLAIDSQNKIKIPKLNGILPIIKAMNNFPNNDEVQFVGCGSLATISSLKENQVEVEKLNGIEAVIRAMSKFSMTELIQDFGMEILSIYITPQINQTHHQVIGLNGIEIIIKALNNFPNNQILQQNGIFCLLHLIFGNKENSKEIFRLKGIEPIVRALNNHPSKPSIQIYSCQILGLLANEKEPQDEIRKFKGIEPIIRSMTNFPNNENLQKVSLMAILNLGAENLENQNLIGKLGGIEQITKAMDNFRNNEVIQSRALNSLLNITPYNKNTQLLVRKLNAIPKIVTAMNTHQNFQQVQEYGCGAFWNFAIDNEENKNEIRRMNGILAIFKAIDEFELDENIQFKGCGALYHIISHIKENQDEFTRLNGSQKVLRILKNFPNNQTLIDQVFKILIVITYQNFEIQNQIRKLEGIPLILKTLNNSIYNQNIQKIGVELMSHLVYNNQENKTEAINNQGMESVIKSMNTFPNNEKIQIDGCDFLINSFYDENLLPVQFRELRGFETILKLLINFPNNENIQSKSLLILINNCLNNHENKIEIKNLKGITPVIQSINNFPNNKKIQLYGSRFILSLAENNQNRIEMRKLDGIKPVIEAMKKFPNSKRIQEYGCITLLHLSTGNIENQTQIGNLDGIQLILKALNNFPFNEKIQLMGLHSLVEISNQNNRNQKKIRDLKGIETIIKSMNNFSNNQNIQKKGCDALLNIAFDYESQDEIRELKGIELIIRSMKNFPNSQDIQWKGCYALMNIAENNNQNQNEILKLNGIEIIMKEMDDFSFNSIVQEYALGALLSLSVHYESKKEIDKLDGIKKVQQVMNKFKDHQIIQYRGAGILGNLAFNNKKNLSQIRKLRAFDDIIEAMENFPNNEEIQFYGCGALANMAISETNRIEIQKSNGIDIVIRLLSNFPNIKYIQSQGLYTLGNITLSNEFQIIFSETEKLQTILDTMNNSLNNEEIQFYGCRVILNISFEEENQKKISKLKAIETIIISMINFPNNQEIQENGCGALLNLAFNNETNQRKIGNLEGIKLILKAMINFPNNQLIQENGCGALLNLAFNNEKNQKEIGKLEGIEIIIQLMNSFPNNQLIEYYGCGALLNISLNNEENQKKIGELKGIELIIKLMDNFPNNQEIQYQGSEVLINISLNNKENKKKIGELKGIELIIKLMNNFPNNQEIQSQGCGALLNISSNNEENQKKIGELEGIETILTTMKNFPNNQEIQSQGCGALLSISSLNIKNQQKIRKLEGIETILTAMENFPNNQEIQSQGCGALLSISSLNIKNQKEILRLKGVETIIMSMDKFPNNQEIQENGFCILASISHENKEFFEDQEIEKIIIETMKKSSSNQNILYKGCEFLRNIAFNNKKQNEIRDSKGIETIIKAMNNFSENKEISKKAFGALLNISFQNKQNKKEIFELKGIETIFKIMIKFENDGKIQGKGCELLTILSFNEQEIQKEIRNMKGIEILIKMMNNFSENVYIQERACGVLRNVSLNLLRFKESEQEQENDLGIIKMKEIGIVIKVMNKFVDNPIIQENGCAILSVIGDDEEYRKEIFELKGIERVIETMNRFLDRMEIQYQGCLCLSNIGFNSKENQIRIGEMKGIETILQAMNNFSNRVEIQFQGFRALANLAFDKKNQIRIGEMKGIETILQAMNNFSNRVEIQFQGFSALANLAFDKKNQIRIREMKGIETILQAMNNFSKNEQIQEKGSRALMNIAYEEENGTKISELNGIEMIIQIMKNFPNSERIQINGLGLILNILSFNNEKKQKHFDESNGIDIVLKSMEIFINNEEIQENGCAIFMNILFKNKEVKGVETIMSAMNKFPENEEIQENGCGAFWNISFNEKNNEKISKINGISTIIQTMNKFENNPNIQYQGLRALWNISVNDINKKIIGELDGIKTIIQAMIKFPKEEIIQITGSGVLRNIVVEEKNQEKIEKINGIQTIITLMKNFPKNEKIQENGCGILCNILVNKKNQKIIRELKGIQIVIQGMKEFPKNQQIQESGCRSLWIMSFSKKNQEEIQKLDRIEMIIKAMDNFSSNENIQEYGCGILWNILFEIYENENENINENENQTQNNENIKIKAIQIIIKAMNNFPSNKNIQNSGCGILWNNSFDEKSIKLIVEMKAIETIIKAMKEFKSYQNIQKKGCGSLWNIGVNNYEYQTKIQELKGIEVVIQTMKNFSENEEIQYFGCGTLWVLSFNNEENKNLIKNLEGFELIKSLKTKFPNYQDLYNLANNSLKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RES0</accession>
    <name>A0A9Q0RES0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RES0"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="75" mass="9162" checksum="8D0583FCFA87E3D1" modified="2023-09-13" version="1">MDNNNDNNQIENANENENENEMKNLEKKFINQFYLQDLLFNELLRQESLSISLNQFNKKKWNQFLSYIYYGNISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF22</accession>
    <name>A0A9Q0RF22_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF22"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="561" mass="66557" checksum="49B537B8B0CAAC0D" modified="2023-09-13" version="1">MDQINFLEKQSSNKPLRRMNFSQLLSQHSLKLIPINKYTKNKKDKSPPSPRYGPVLTSQQITPLYSMANNVLENDTPKRKPHKHSHLKNDLEKLEKLDEPIQNSQTNLTQRTSFNKEQFIHKRNNPLIENKQNQQSQSFDYSSLKNPYLFNKQKEIPKSSKKNHQLQTNLKENEQIEVKFYDHNNRLENINSMIDSNENYFSSQFPINSRNVSMQTPTWNSQKWSPSFLAKPYVYFDIGTQTNESSFPIDLRYHFIEIDINEEIRNQMHTKSLHKHHHHHQPNLFINQDSTNIKKKSRRRSSNLKSYNINKQFDNSQRELEISYAYPRFKQKQQFGNEFRSATPDVGTIHHSRRQISPRFTQKRFPESPTRKIYDEDLQNELETYSLADNHFSRKFQFENEKNPRNQFLSRFDSKVSDRPSDPLAKGFDREEFMTLSETQRHQSTNRNVENLPEKLNFETKPNSKILFNQQEKKINPNILDRQEKLDYSQNKPSFNPTKYSEKHLPKARYSRQHDRWIGVSDQIVSRMKGPDPSKRSEISSTRSQSTAFSSTFSQKSFSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF77</accession>
    <name>A0A9Q0RF77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin cytoskeletal 2a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF77"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="534" mass="61619" checksum="68D2327915B4FD2D" modified="2023-09-13" version="1">MIVIDIGSYSFRVGFAEDPKPTEILLPVIGEIKEAKYKEKIGKSTFIGNQALEKEKYLNLSYPIQEGIVNEWESFEKFLEYFFTFIFPIVPNQTTMVTEPPHNPKQNREKTLSLFFEKFGFGKFYLAAQPVLSLFPLQLTTGLVLDIGDSLTYAISVDKGFALLSSLQVVKTSGKDLSNYFINLFGNELIFDNLLQKKQILEDIKHKLCFVSTNFEEEILDKKFETWKSLQYELPSGKTISVGNSCINCPESLFKPSIVGNNDIGIHQAVYNSIMSCSPKSQDSLFENIVLTGGSSLFPKLDIRLKNELLKLAPNKDINVILPDDPNLSSWIGGSFLGSLPDFASMCVSKQDYDDYGPSIVHKRCDFVMDSFLDQNENLIETFDFSESFSDTSTGDEFEEIKDDKKDVKDDKKEVKDEIKVVKEEIKDEIKDDKKEFIFEEVKDDKKDDKKDDKKDKKDDKKDEIKDDFKEFIFEEVKDEIKDDKKVKKDDKKEVKEDKKEFIFEEVKDDKKEVKDDKKDEIKDEKKVKDEFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFA8</accession>
    <name>A0A9Q0RFA8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein rab-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFA8"/>
    <dbReference type="OMA" id="RYWANEL"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="232" mass="26818" checksum="6B2B02F627D5B4E6" modified="2023-09-13" version="1">MSFDLISKVVIFGASQVGKTSLIIKFVDDIFKNKGVPTIGVDFRTKDLQIKTKTVRLQLWDTSGQEVFRERFTSSIYRKAEAFILVYDLTNKDSIEELKYYFKEIQENCPKDVVIVVAGNKSDLDSKIDNPEEELQTCCKEFFFKHFKTSAKNGDNINELFNYIASSVYLKMVTNPTPKSTFTPYPIREIDPSEFIPFDPLKDLPPDFIEQDHNNEPKKKIKSKFKKCCSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFC4</accession>
    <name>A0A9Q0RFC4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFC4"/>
    <dbReference type="OMA" id="KHGSTIH"/>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="163" mass="18458" checksum="9B455C684E0D0936" modified="2023-09-13" version="1">MANQSEENKMQIYVKTLKGTSQAFGISNDETVDTLMNKVEEQLGIKKKEQRLIFGGKNLISGKKMTDYRIKHGSTIHLVFRNIGGMSQIFVKTLQGKSKAFDITNDETVDTFMNKVEQEFGIQKDQQRLLFGGKNLISGKKLTDYRIKHGSTIHLVFRQLGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFH7</accession>
    <name>A0A9Q0RFH7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beach domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFH7"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF86">
        <property type="entry name" value="LYSOSOMAL-TRAFFICKING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="318" mass="34933" checksum="31EB797DA167E999" modified="2023-09-13" version="1">MESDQEKSFSEAFLTVKSLANLSALSIQTTKKRISGLFAVGNNAIGLQGSSVSLARDNTKIITFGNWDDTIRICIQDTEKVIYSIQPVHQETTTSCVCIPDGSGIITGGSKSIITIWNLNNDSKENFFISLKRQLFGHTDTVLSLDVSLDFRIFVSGSKDCSAIIWDLDSLNCAFSLDDHVGSVTHVAISPQNGDIVCFASDSICQRNQLSLWSINGHLIARKNFPNFNNSLVSSILFSPKSVDLVNQWLFTGMVNGDIIIWDAFDLQQVLCLNSPENSPVNGLCFSTDLKILFSGHSNGKIISWGSSSKKKNKEKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFK4</accession>
    <name>A0A9Q0RFK4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFK4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="310"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="415" mass="48571" checksum="8568ED61E1E1F6B1" modified="2023-09-13" version="1">MMKNVSKIFSGNTSNYVFLLNSNQELFGCGNNQYGKLGLGESKEETQIQKLTKIQNIPKGKIIDIQCGYYHSIMLIENENENPKRKLYSCGFSLYNGLGKNENTYEFTEIKSSLFENDDIILDISVGDFHTLILTSNSKLIGIGNNACGQLGNEDTKHHLIPIQIELPKLKFNEDISNYHISCGYDKSFLYYSPFLSSFSNLEEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLNQNEIEIEKLEEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLIKQFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFT1</accession>
    <name>A0A9Q0RFT1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cofilin/actin-depolymerizing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFT1"/>
    <dbReference type="OMA" id="YAIYDME"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="140" mass="16381" checksum="25BFF324DC3C6FD0" modified="2023-09-13" version="1">MDAGIRAEDECIKKFNEFKMGNQISYLIYRLSDDLKRIIIEKIGEKEEKFEDFVSNFIEKKSRYGVYCVNYELDDGSKRSKIVFFSWIPRGASIKEKMLFATSKSKFKRELVGLSVEIQATDESEITFENVIEKVTSKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFV2</accession>
    <name>A0A9Q0RFV2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFV2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="235" mass="27742" checksum="66E73887EFB15852" modified="2023-09-13" version="1">MHSHPFNSKTNFFSNSNQKPNSNQNSLYEDLDFFFESEFCFDPFDFSFPTENIFISEPLDHILLKNTEESTKTTNEPLNCIQKETESKTENIQKSNQPFKIRNGSNPNKRKKRKEPISCSPFSSELVLNDSQMQKFRQFWKILPKLRYLSSIFPNEFEGIDKNTDFHNLKSNKITISRRLIQKTAEILGLKEQNLIRSVKRAIMNKGYKYVKAEHHNFTHLRFAKKPKNKTHQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG20</accession>
    <name>A0A9Q0RG20_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG20"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="105" mass="12267" checksum="4946DB59EF61377D" modified="2023-09-13" version="1">MKRFSRNNSVQIFQVDFPNDDCFCINLPSSVQLILKLLSQYPQLKNIFPFLDNANLFSSMIFSLINEHPIRFCVFVIRSISKMKGRDELFADIASFLISCEGFWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGQ2</accession>
    <name>A0A9Q0RGQ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Receptor-type tyrosine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGQ2"/>
    <dbReference type="OrthoDB" id="5854685at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="153"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="233"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="419"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="521" mass="61091" checksum="7A5A66AC59094A5D" modified="2023-09-13" version="1">MNKIEDLLKNYSNLNYKQSRDIYPSHQKSNKNNETTEATESENLPKNRYSDVLPNNKFRVHLKNSVNDYINASFIFDNENTDIDNPKYIACQCPLLRTQNDFWQMILEQNAFVIVSLTDAQRISHRNIRTKCEKFWPKKNSPLKLNNIIIEHAGIGRTGVFILVDLILKRLKNAIIQQKEKGIEIPKQILDIPETLIELRKYRYGLVQTVPQFQFAIHMIGKVGLEIFIKKLFQLKLQKSQDIYPSYQKSNKNNETTEAEKPENMLKNRHSDVLPNNKFRVHLKNSVNDYINASFIFDNENTDIDNPKYIACQCPLLRTQNDFWQMILEQNVFVIVSLTDAEHLSTDENNRHKCGKFWPKKNSLLKFNNIIIEKRSKDFHENCKNLVIRKLEIKYEKETRIISHIQYLGWPDFGVPETTEEFELLRNFVNENCEKVPIVVHCCAGVGRTGVFILVDLILKRLKNAIIQQKEKGIEIPKQILDIPETLIEIWKYKYVLQSIPQFQFAIHTIGKVGLEMLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH33</accession>
    <name>A0A9Q0RH33_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab-gap/tbc-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH33"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="456" mass="53388" checksum="9035DD50F9062495" modified="2023-09-13" version="1">MFGFDHCISELSDDFEEELVQQSQEQIQLFSQRLDDRHLSFLDNKIDNKNSKQEEKEKEKEKEKNTQNKINKNKNKNKNTNKNTNTNKNINLNINQYHYENDSENDSESEDESDYNYEFEDEDQDEYENYDRDQNTDFIENEYEKEKSKKKNNKRKINNKNNTKKKAKKKQNKNNQNINANKTNANKQNNNANKTNENNINININININQNNQNNQNNQNNQNFAQKSKKQNFAQKTRQTRQKPSDSSQFLTPSQIITNLQDTQPLDRLSPNLIHTTNGEKENKKNNDDMTSNNEENESENAYEELVTFLSQKPTPKIGFRLDKIASYDSTILLGWNQGSYKAFLSDGSIPDHVEVFDAVIELLVSVKGRKGRTQSSKFPHKQKVVKTKDWRNTRRGIAAFLQKSMGLINITNHRHGKMVFAKKEFVDLFEKSPQNEHGQSPQTKNQTENQNQDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH92</accession>
    <name>A0A9Q0RH92_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH92"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="371" mass="44054" checksum="DA85E89FE7DF54DB" modified="2023-09-13" version="1">MTNQLQTQNLQNQISQLDNLILKQNCLFLSIKKKHQTKRLNVDSEIQFIETEIDFRNEQMKNLMERNQNLISTLNTKKEFLTEDNKQINEISKSIINLKQETIREPKTPKKEKMQLLTKSVSATKIKRAKYLQQQIDTIKQKKETESKEVKRLQKKLEKSKQSATNYRLNHDKMMQTFETQKNSAIERTKELTQLIKDLRSKTRDQNQNQNLDPNAKVIDQQIAETKKTLQQLQMKLVRKQEKYKSIENEYELITKENQKIQDSLKNYHKDHIWLGDVGVYQKSIEEESKKIATEIVTQKSSFGSLNEEIKKWENLLQQDRIDFPSQIEEKEQEQDKKDLSKLLYYGVPAAIASVLILKYQNFFSFKFNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RIG8</accession>
    <name>A0A9Q0RIG8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ARMC9 CTLH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RIG8"/>
    <dbReference type="OMA" id="KMYLVNA"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0141039">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0045022">
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    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
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        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
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    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="7">
        <location>
            <begin position="62"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="285"/>
            <end position="317"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="415"/>
            <end position="456"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="456"/>
            <end position="497"/>
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    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="195"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23138"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5079769.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="585" mass="68143" checksum="DE2BDE501FAF1D27" modified="2023-09-13" version="1">MQNSFTELPALHKSIKYCDHLVSEYLLFRGFKNAIQCLENDKNNTKTHEFKVKKLVDEMFCLISDYEAKALSRLWDYFDKIFFKHLDNKISVMTIKIINSLKKYYIVNCISHQKFDKVKEFFEIFADTMTKTPEMLPWFSILYIENPEKDPRFSAYFSLKWVETLKESTSNFFNSLFENIPRPRLLNFYSEYMEKQALENLIMTFEQKNEATRNQISFLEQEIHNLKEKAESLRISNQPIKTTENIIEKKSQEIKIIEQTKEIEISQEKEIPKSNDTFDIIERIEYIHSGSILSCRISENTQHFASGSSDGTVKIWKNKSKTRKFKVDSPVRSLEWSQNGNFLFCGTSNHKIQVWNREKNSILFSFDKLPFPKVSAMRIHPSQQIVFASTLSNTNKSGSLDSIILKDGTKKNFVIQAENTGINSFDLNHNGSLIVTGGYDGVIRVFDMNQKEIMEWKAHQKEITSVKITLDETGVLSVGVDGKMFLWSLINQKQYLQEFQLPNLDFDQLSKKPSIEIATENNFFLNLESEEIQIYNINKSQPTQILTYPYTISCMDLSLVNRFAIFGTDKGKTILNNFSINSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L574</accession>
    <name>A0A9Q0L574_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_03454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L574"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00864">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="711"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="964"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5066121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1246" mass="144605" checksum="44AFFAEF656F9212" modified="2023-09-13" version="1">MLKFRKPPPPNVSRRLNHSHSYRSESMRIIPTNYLSSEQKEIKTKEHPKISLSKRNKNRPIRTQSEAFGNNSNLNANLNTNLNTNTNINSNINTNLNTNLNTNLNTNLNTNLNTNINTNLNTNLNTNSNTNSNTNLNTNLNTNTNLNTNTNLNTNLNTNINSNLNTNTNLNTNSNLNTNTNINSNINTNLNTNTNLNLNTNTNINSNLNTNLNTNTNLNQEIFQKSIDNFQSNLISKSHFNPSFQQNDDPKPIPKLSRHNYLRKYSLNEQKLKNNQIHNFHQKILIRKKNTNSISEKKPISNETESISKSSLRLSPKNKEKNIHKIKSTHKSKSHSHSQTDKVQKTHKTNQVEPISDPKKLTRFHSSQNSILHKDKNEVNYPKPRKNIKNSSKTKNNEKNRKHEKIKKNGKHESKTKSKSSKSNSINKQSKSHHLSIEKKDLNQFNQEDNIEHLTPKNNKTLRHHSNYPSRKTDQNINENINENINQNINENINENINENINQNINQNINQTINQNINQTINQNINQNINQTINQTINQNINQTINQNINQTINQNINQNINQSINQNSNENSNNYEKIIHHAKPQRSISFYKVTKNKPPPRPQLHLPKEEYHSPRKKKSTSTSQNKKHKNQVKYMTYNPTHSLNEIRKRNRKLHQKNNENQNELEKESKSKIETRKSSNKQSPLSIESTNHIKQKKPKQNSVINYSRDVSKPNDPPTLSEYKQIQLIVSYPPIKDLTQQERDLIFHYRKAIRLQGNALPKIILSTNLDNQAERKELETILKEFQEIDIVVILELLSKKFKDSNIREFAVHKLDNQKDEELVFYLLQLVQGIRYEQSFNSPLAQFLISRAKNNKIFAIYFYWFIWVERNDKDFRIFANVQQEFVRQCLQTELGNDILSIIQRQEELVQNLIMMIEKVSTMKKSREKKISFLKNQFKNGQAYSHLSQFENLPLPIDPMIIANSIIGDEVHIYKSALNPMKLSFNTILDEKYQIIFKSGDDTRQDNLVIQLITLMDKLLKQGSLDLKLTPYKVLPTSQKSGIVEFVNAIPLSKILAEYGKISEYFKVVDPDEDSEFGFSHTIMDTYVKSCAGYSVITFLLGVGDRHFDNLLIAPDGRLLHIDFGYIFGNDPKPYPPPMKLCKEMIDTMMGIKSPHYQYFKILANSAYNVLRKYSHLFVNLLSLMIDCKLQDLEKDPLESILKVQEKFRLDLSDEEASIFLSNIIDDSVSALFPIVVDKIHQWAQYWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L699</accession>
    <name>A0A9Q0L699_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Wd40/yvtn repeat-like-containing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L699"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044715">
        <property type="entry name" value="WDR86-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489:SF11">
        <property type="entry name" value="WD REPEAT DOMAIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="154" mass="18397" checksum="4422F48C94D45341" modified="2023-09-13" version="1">MSQKKQKEQQLKPIKEFTGHSREIRCLLITSDSLYSGSYDQTIKKWDLKTGKCLWTSNAKSYLFSLASYQDIIFVCGYQIYGFLKKNGNLQIEYPTVFSQYFFTICIHDHQLFAGNQDNFLRIFLIVSLQFKTQNNYNKIYNKIYNYIYIYIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6F1</accession>
    <name>A0A9Q0L6F1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6F1"/>
    <dbReference type="OMA" id="MLEPCKQ"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="515"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="693" mass="80255" checksum="D0F1D40784B445CA" modified="2023-09-13" version="1">MDPFQDLISITQKIHFDFLNDENIDFPKIVVVGGQSSGKSSVLESIVGRDFLPRGINMVTRRPLSIHLQKVAVNCPLFYEKEVKEWAVFAHSDKIFIDFEEVKKEIEEATNRVAEPGMVSDLPLELHFFMQNTVNLTLVDLPGLIEVPVGNQPESIVMDIENLVKKYVEKENTLILAVSAVNEDFARSHAMKIARQVDPQRKRTIGVLTKLDIMDKGQNAMNIISGDLIHLDLGYIPVKNRSQEQIKKNIPISQALEEEETYFSEHKDYKVIADKCGVRHLSFRLSELLFQHIKEYLPKLRIKIVTILKENDEKLKKLGLDNIVENSMSRSYLALNLAEKFSLYLHDIIWGSRETLSMNNLTGGSILRVEIEKFQKEVNKLNPIEKYTDKQIQTIINNTLQIAPSLFVPQAAFEQLARECIKELKKPSECCIDQIYNHVVEIITNHNFYRIKRYPPFNDFIVKICTKFFGEKIQECKDFVEKMIDIEMAYIFIEHPQMKKFQSKPQKDEKPKNQVQTLRNLTNQYFQIIRKKISDTVSKSAIQFIILSPFDDLFSILHKNIDENSKKLKNLLKEDKKTLKIHQELLEMNSKLLNARNILKSISQINFLSQQKTETHFSQNDSNDNSDPEKKKTTSKTKTTSKKTTPKKTTTNKNKNKNNNNNNKNKDNKNKNKNKDNKNKDNKNKDNKKGNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6Q0</accession>
    <name>A0A9Q0L6Q0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6Q0"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="444"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="617" mass="72451" checksum="C6D987E7F51FAF0C" modified="2023-09-13" version="1">MLEWINIKSSSKTYPSKRYGQSITLCETEDGKKFCLLFGGKCSEIRHNDLWELNIYTKKWKKIEIKGSKPAGRTGQTAFFYKNQFYIFGGSSRLNRDMNDMWRLDIKKQIWEEIKYNGKIIPEFRCYHSSVVYDNKLWVLGGIGRNDEILKSFLKFDLETFVWEYVHSIVGRIFRHTASVISDSMYIIGGSDGNNDNIKDIFIFSFQNQSWSKPKLDYIPPLVCGHSAITFDNQVCIFNGMLESGDFTREMWVFNPLSYWHQLKTNGVEYPWRFSDSSFYFAGKIYMFGGGYQANSEPDWHYHSDFLEILVDPIDNMSSFSQDMKNLLFSQNFASKSFKCIDGEIFVHDLIMKCRLKEKWNPLLFSLQFSGNEKKEVMDFLLWVYTGGILDLKLPLEQILQIKNIAEKLRIDSLLDQIEKFEKTGEFELVEKNLEELLNEESTKDFYLIVENQKIAIHKLILGSRTELFRGMFLSVQDSKHEVHDLSGRSYEAIQVLIHFLYTNQLSNLTMKIALELIDANQYYGLNSSFFQDSIVHFIHKNLSIENVKDVIKNISGLEILSLENKIMDFVIKNEWKFLNDDNSFYKMFKLNNPDFEEKKQKNEQDILLFAYETFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7P4</accession>
    <name>A0A9Q0L7P4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 35 member f5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7P4"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1108"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1141"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1170"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1197"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="175"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="846"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="947"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="523"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5067606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1242" mass="143015" checksum="B84D52F0C041A40B" modified="2023-09-13" version="1">MSNKNRFQFQNKNQIQIKPENQMQIQNEMQIEDNSNLFRIETNFGQFTSNQNQNQIEKQNQDFNHIDELKEYKEAQKEYSNFTEEYWETQKSKFREIHKIIKEGSGSKLQIFLENKINQIQNQNQNQNQIENSKIIYNEEDKQNGLLPCTHICCIHSNPELIQIIHHFRNEFKQKYFEKWKGNAFFGLAYLCGYHNTVRKLLYLGYNLDFSVNLKEIGINPEKYKEELKNIELIKQLPILKKIDFKIEKYENFKQPIYEKEIKKAKLWINHKWELIRVQAIDYGHFHPDTLIALSISQNNPNLIKCYGIYNNKESNQILIFIERWDCTLENLFEEYENIETYQKEEISLNILERLKIIHELKLVHCNVLPESITITFNSSTPLKIGRFENTRRFNSFTFASAFHDIIQILNGKITPKTDIYLFGYTIYFISFEKKPKKLDKLQEKKITRNFLGEYILSCCNPNPKQRPTLDKLIYDFSLIKKNMKPNRKSNSISISISISKSNSKSKSKSKSKSKSKSKSKSKSNSNSNSNSNSNSNSNSNSNSNLNSNSISNSNLTPKSKSNSNLNSISISNSNSNSNSNSKSKSNSNSNSNPNPNSKSNSNSKLNSNSNSNSNSNSNSISISISNSNSNSKSNSNSNSNSISNSNSNSKSNSKLKSNLNSNSNSNSNSKSNSNSKSNSKSKSNSNSNSNSNSNSKSKSKSKSKPKSKSNFFTNDPKIFFWVSSSELMSWMFQDLEFEEPFFLTYFNVILYVICFSFPILIRCKWKQDTKIDFKSNKEVLIEDIKESESDDIIGYETFFENENENENENENENENENQIQNENQIQNLNLNQNQIQNQNQNLNQNQNQNQNLNQNQNQNLNQNQNQNQNQNQNLNQNQNQNQNLNQNQNQNQNQNQNENLNQNENENENQNLNQNLNQNLNQNQNQNQNQNLNLNQNQNQNQNLNLNQNQNQNQNENENETDSNSQTQPLLLVQQNQTQKKLTLSQTFKIALKVFLFWFLANYTFNLSLTMTNVGSNTILSATTGFFTLFSGYFLHVDTFTLIKILATIEIFGGAVLVGLTDKNDSGNSSFMGDIITLISALFYGMYPVLIVKFVGKNIQFEFTTFLAAIGIISLFLTWPIGFILHFSGFEKFRFPSLKIIGYLALNGLIGSVLSDYFWLIAIVLTNPLVSTLGLTLTTPVAMIADYILYKKSFTGIYILGAIMVIIGFVTINLAGNNVWIDKKLSQLFQKCLHKKNKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7Z7</accession>
    <name>A0A9Q0L7Z7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ap-4 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7Z7"/>
    <dbReference type="OMA" id="RPAAIFM"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="176"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="399" mass="46303" checksum="17A1D4C227B0B636" modified="2023-09-13" version="1">MISQFFILSPRGNRLIARDFLHEIKENSTEILFNKLEEENFREFLPAFHQNGTNFIFIPDSDLYFLATSKSNISSSFIIDFLNRIITSIKDFCGRIDEDIVINNGPLIYELIDEIIDYGFPQNTETESLRKYIWNTVVLTSNEDKKHQKTKRTQSIVSRKASKKPIPNIYSSEKEYNEIFFDILEDISVSFSNDGTLIAGQLNGRVRVKNFLSKITLLTIQMNDDLHIGEFKNQLGPGIHISDALFYSKCDSSEFESEGILKLVPPKGEFELMKYRMSGNSIDIPYRIFTSMEEIDKNQLEITVKINSEYPESIVAIPAQVCFKIPEYVLSVNCFLSGNDHYQKAKFDKQTNQVIWDFQRFNGGRHETLRTAFDESKVFNPTRWIRKVTKSKSYIAWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L840</accession>
    <name>A0A9Q0L840_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L840"/>
    <dbReference type="OMA" id="AEIFHAN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="5">
        <location>
            <begin position="220"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="309"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="481" mass="56434" checksum="A6B16C0F023917A0" modified="2023-09-13" version="1">MENQKSKSKSKSKSNSKSKSKSKSKSKNQNQNQNQNENENQNQNKNQNQNQNQNQNQNQNQNQNQNQNQNKNRKSKSKSKSKSKSKSNSKSKSKSKSKSNSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNKKKRKKNQIQNQNQNQKRVKPKLPKHGIKFSENKNTQEQIQQINEFRTDLYNLFSVSRFASDKKIMIGEWDQQNCLVKVDNPKGECIQTMGKVINKSFYFTIEEAIFLLETSKIIILSPNQIQNQNQNQNQIQNQNQIQIQNQNQNQIQNQNQIQNQNQNQNQNQNQNQIQNQNQNQNQNQNQNQNQNQFENQNQIQNQFENQFENQFENQNQIQNQNQNQNQFENQNQNQNQNQIQNQIQNQNQSKIKIKIKIKIKLKIKIKIKNQNQFEKSKKSKSKSKKSKSKSKSKSKSKSKSKSKSNSKSKSKSKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8C3</accession>
    <name>A0A9Q0L8C3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8C3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="715" mass="83621" checksum="F46E6208ABC20DA0" modified="2023-09-13" version="1">MLEVKLKKFNDNNQFFNESFKESKPFGDFVAILNEEKELNIFYYKEIIETSNNFHQLVPIPESKIPDITSYFWGRIHETMIILLALDKNYIVHLYRIILPKAKINLSNSEIFEIHEIKTEYSRKTARKGLIHFFEEDPQKITNQNQSESAQIHVFKTQIQPDYLHQALGKPTTNPYERDLKSLAIVDLISAKNQSLNTLLILSSNVAVICKITENHFYGVEMFILSGEKNKIIPFVQFRRKQDFLYALCEKGKSIHIWDISHAQKVAILKISKIAFFKKIKFKIEKNCIQFDVTQNNSKLVICYSNRFLFVLDLDEYFFNYQNQLGISLIKPQKFPYVFQDPKDQVFDLYQHLHKKFVPPNDAFCSLDSYLFDKDDPNQDPELEISKQKFDSDIHQEWLIGKHVYEQKVCGMFVEMRKMRSAFVFHWPHLIENRDCSSEFQPSWSNTHQDPSLRSGQHLQYHHENKICTILALINNSITIISPKKFHHVSKKKPKLFLGKFLLLNSQVLLCYSDKNPVSVTDRRDLCSSAFLLNLDHLNQQKFPISSISFNEPTFIYGELNKNFFSVISRSGINAVVLGFTESQIKKNIAMFHSNQSTQFIAKINNWVLGSYDDTLLENALTKQDFQSIDEMIQSQKTQEQIIKFLTQMFALLQEKQLATFDPNFLEDVFVKSRARLVEIIRNIVSESNENLENKFKSERSSFSSKFTCDCSKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8S6</accession>
    <name>A0A9Q0L8S6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8S6"/>
    <dbReference type="OMA" id="MSICIDM"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF3">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="277" mass="30849" checksum="24D7FD3F06DB49AB" modified="2023-09-13" version="1">MCDFVATGLMNIGLLWIPASIWQMLRGSMVVFSAIFSVVFLKKKLYLYNWLGVLSVCIALFMVGYACIKGDSGHFDKKKEAIGIILVVAAQVIQASQIVIEEFLLKDIKVSPLLIVGLEGFWGFMVTTILCLPIVSVLPGSDGDGVHENTKDSFIMMGNSGALTGLVIAYVLAILGYNMFGMFVTFTFTAVIRTILEAMRTLCIWIVDLIIYYGISVYYGEKWSKWSYLEGAGFILLVLGLFIYNEVLHLPGLKYPVKKQKEVQEDKSLLDDDKNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAI7</accession>
    <name>A0A9Q0LAI7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emopamil-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_11660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAI7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="708"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="860"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="940"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="620"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5069317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="960" mass="112383" checksum="893410918BF2C49D" modified="2023-09-13" version="1">MNQPLLNNDNDTNSNGKSESESESEDENQLVVYENLLPKPEVHIVPKKNRNQEKSGRFPITETYWEIIFSLNQIGKETNGKKCSSFSCKKISKTFAILMKSLEFWIFLIISLLSILGMTLPSLIIGKKNQNSDSKYDCWIWIKIFNIFWILLLFFQIIIFSISRNLKIKFWINFIRIVNSLIILFLTSWSIYGLVISIDNFDNSNSTSSTISSIIFIESFIFIIISSLFIIWLIYESFFKEGDLKYKMKILLIGIITTIIIGFGMAIPCLIIGTKSRNYSNWKIDFIWILIFNIFWIITTFITSLSLILNGFKNFFKNLDIPKNQKIMITFTLIPIIFLLSWSIYGLVISVDNFQNSNSTSSTISSIIFIESFIFIIISSLFIIWLIYESFFKEGDLKDKMKILLITIITTIIIGFVMAIPCLIIGTKNRNYSNWKTDFIWILIFNIFWIITIFITSLSLILHDFKNFFKNLDESKNRVIITFTLIPIIFLLSWSIYGLVISVDNFDNSNSMHSTISSIIFSESFIFIIISSLFIIWLIYESFLEEEEDFKDKMKILLITIITTIIIGFVMTIPCLIIGTKNRKYSDWKIDFIWILIFNIFWIIITFITSLSLILHDFKNFFKNLDESKNRVIITFTLIPIIFLLSWSIYGLVISVDNFDNSNSTSSTISSIIFIESFIFIIISSLFIIWLIYESFLEKEGFKDKMEILLSGIIITIIIGFGIVIPCLIIGTKNRKYSDWKTDFIWILIFNIFWIIITFITSLYLILHGFKNFFKNLDESKNQIIITFTLIPIIFLLSWSIYGLVISIDNFDNSNSMHSTISKIIFIESFIFIIISSLFIIWLIYESFLEEEGFKDKMKILLSGIIITIIIGFGIAIPCLIIGTKNRNYSNWKTDFIWILIFNIFWIIITFITSLYLILRDFEDFFRDLDESKNRVMITFTLIPIIFPFKLVNIWISYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAP4</accession>
    <name>A0A9Q0LAP4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAP4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="67" mass="8157" checksum="997FF8DF0D104796" modified="2023-09-13" version="1">MISNNQILFLQKKENKNPLLKEKKTKNKPKYDLRKTIPRFFDSTLKMIPHQKNKGNRERLIFTKQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAP9</accession>
    <name>A0A9Q0LAP9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-coa-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5068995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAP9"/>
    <dbReference type="OMA" id="WKVINIK"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="316"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="431" mass="50239" checksum="4CBE6285AD5E9ADC" modified="2023-09-13" version="1">MSFTWKEIESRSKIKPEERFRASYTLYNNKIIIYGGCKIENYRKYIYYDDMYEFDLATKKWSKIEQIGDLPAARWGNTTVVHDDRLIIFGGRQKSKEDPTPFYFDLKKRVWSNLDTKGDSESLYYHASVVYKNRYMISIGGLIPNDKYNTKIYSLDLEKLEWKVINIKGENLSPRFGHTAVIENDDIYVLGGYKRYTLSGLFKFNLLSNSWSRIVVPNDDIWTMKESHSAVLDPKSKKMIIFGGLKRVDGIETNFNNITTFNLITQQWEEVPTKGQPPRTRDDHSAILSNNKMYIFFGTSGNKVFYNDMFELKFGSDLSVHMHAFFDNQEFCDVEIISCDDQVLKAHSSILKGRLKNHYTPSLIAQLGRFTYSEVRSFLTFIYTGKLEINQPEATEKIKKLIEEFKLKNLSVVNAENCENELENDMLEIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB02</accession>
    <name>A0A9Q0LB02_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB02"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="78" mass="9304" checksum="028EF9CC4C0A7B50" modified="2023-09-13" version="1">MFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINELEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBZ3</accession>
    <name>A0A9Q0LBZ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MateRNAl protein pumilio</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBZ3"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="555"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="576"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="647"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="684"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="756"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="792"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="828"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="895" mass="104705" checksum="665C284ADEE7B767" modified="2023-09-13" version="1">MNQNNLNQTENSPSKQNSIEKNKPLEQIFLNFSQLNLSRTRSAPPTLVKEMAKTQLTPQEPEDFRFKPEYHEEYKKTLYQNPRYPPPLFAFPMRKFEENNPNQPKDLKFDLNFQSKIRQEITPLKFPLFSNLSKNTSNQEQDKNPQIDNLNQLQIKPNANAKETSFEKNDEIKPKETNKEQTESPTNISFSHFPSNPIQNPIQNPIQNPIQNPIQNPIQNLNQNTIQNPIQNTIQNPIQNTIQNTIQNPIQNPIQNQIQNQIQNPIQNSIQNQIQNQIQNQIQNQIQNSNLNQNKNLNKIKESLSSPKKTENSMLNIQPNQFSYNPTSPLKQYPPRNQKMFSLFDNFEQENTFNFNQLRPKVSLTPEPKSTTFFPTQSGILSQEDSSKIPRSQTMSPLLQRTSSNPNNNFYNLDSSLLAPRTPSPQIMNRYTEFQPQMETPSYSYDSYYNQPDYSHTNNPNYEYQNPMNQNPYQPYFFSQQQQQPLQQPQAYHYSPDPSYWEQNQYYDANYQYSISKQSYPSQFPHSRTERGVNPRSKTFKNGLNHHRSGLRPNSVTAILEDISYNKNTQGYELKDIFGHLYQFSIDQHGSRFIQQKLETANEEDMQKIFEEIRDNFFNLIEDIFGNYVVQKFFNHGTKQQINELVELLKGHVNQFAVHIYGCRVIQKVIEVTSIEQQEFIISELKQNIKKCVYDQNGNHVIQKCIELIPQKHIQFIIDTFYDQTIQLSTHSYGCRVIQRILKHCTGTEVDRIIEKVLSSSMDLVFDQFGNYVIQHILENGTNEQKNSIIQKVFGRVLEMSQHKYASNAIEKCIEFGTPQQTKQLLNEILDNGGEYLRVMMIDQYANYVVQKFLERLKGKDQKKLLNVLKQNMRSLESNSFGKFVIAKMTNLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC14</accession>
    <name>A0A9Q0LC14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC14"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="356"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="535" mass="63877" checksum="82B3B33F494A9B45" modified="2023-09-13" version="1">MDNNNDNQIENANEIENENQIENANENQNEMKNLEKKITKNLIKDYSNLLKGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLNSNEIELKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNKRLKLKKYEQKMNAKKRLFHSFFSLFDKDSISKQNFDKLKQFDFFLPNSFLVDIQTQVIQDNQKENKQMKKEIEDKWKKENQQMKIEIEDKWKKEIEKMKPIFDKYEKKMKDIKKNFPQFSDSEIVKDIEYVKKLKEWINDNDFFSKMKKGFSAKRDGFDCKKWHSKCDNKGKTLVIIKTKDNFIFGGFTQVGFRGNYDNYIHDSNAFIFSLRNDKGDRTPENFSIKQGQESYALVDNSNLGPIFGYGRRDLNLNYNLQPGHSDFGSSYNLPNGINYGTNEAKSYLAGSYDKWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC26</accession>
    <name>A0A9Q0LC26_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-l-methionine-dependent methyltransferases superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC26"/>
    <dbReference type="OMA" id="FINAFVP"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="200" mass="24099" checksum="C52F72B37BDA19B7" modified="2023-09-13" version="1">MNFTKKEYWDNIYSSEKQEMDWYSTFSKIYPKIKHCFIDKSMKILQIGCGTSNFAKKLYQKGFSEITNIDISETAIEKMKKKYQNLSIKFEIMDTRNLTFKDESFDCIIDKGTLDSLLTEYPKENSLKMLSEIYRIMKPNSIFIEITWGTPFDRMFYLKNKKFKWKISHKIISCEKEEEKFTFYIYFLRKGKENEETKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC72</accession>
    <name>A0A9Q0LC72_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_02542</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC72"/>
    <dbReference type="OMA" id="KLRYRWH"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1013"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1052"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1100"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1130"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1170"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="246"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="571"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5068600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1226" mass="141335" checksum="B53D0F4B371FCDED" modified="2023-09-13" version="1">MFQNESKRLLNEEKQFQAKITDIEEDGTIVECELRFYRKSKKRTTFFVIIAILTVGFSLLLCHWFRKLKLKGTHKKVDSYQDAHKFLILRPDKTYDIVNQETLIYKENGLEQEKSMIKYRYIHYIFNEEHNQFIRVGLNSSKDFSKIRNKFSDGLNNKEIIKKRQALFGQNYLNIPVKSYPALLLSEVLHPLFVFQLFAVIVWSVDNYAAYGITIMVMSLVTIFFSLRQTKKNLVTLSEMAKFDIDVEVFRIGEYKTISSKDLVPGDLVSIPNNFILPGDFILLNGQCIVNESMLTGESVPVVKTSLPSDTKQIYDIITHKKYTLYSGTKVIESKFYSGNRVLAVLVRSGFDTMKGSLVRSILFPKPHNFKFYSDTFKYLFFLTFISFIGFAISAVYFVKHKNSVYQIVIQALELITIVVPPCLPIVLTTGTGFAIERLKKNSIHCISPPRVNVAGKLNLLCFDKTGTLTTDQLEVLGVHPCSGNEFDKLEQTFIKKEINIPEKLMNCLSCCHSLSKVEKDLIGDPLEIKMFEWIGWELEELDQDQETNLGFDSPISTFVKSPKFSIKNQLVTQNSQDESEDDEDEMKLNDDENEENLADPINININFNNNNHNNHNNNNNNHNNHNTDKNEKSDDKTKDSQIDNLFEQNTIGIIHAFDFSSTLQRMSVIVSNQKTGNFEMYAKGSPEKIKQLCIKESIPKDYETILHSYTKEGFRVIALGYKLIENIEIFEMKTIPRDSIEKDLIFLGFFIMENKLKDDTIQVIQELKKALFYNVMITGDNPLTAISVGKKCEIIEPNSTIFLGNQKKKGQTKIIEWENIDNPNEFFDLSKNVMYYKNSKNEKNEEIEIQLSSDSNDENEEEIQIKNENIKNIELVVTGKVYSTIKKRNPELFERMLIQSHIFSRMSPDQKSQLIGNFQELGYVVGMCGDGANDVKALKSAHVGISLANTEASIAAPFTSRKQTIQSVIDVIREGRCSLISSFQSFKFISLYALIQFLGVVQLYILDSNLTTYQFVYVDLFLVLPLSVIMTRTPASKKLVQQRPASSLISLSVVTSLLGHLIFILLFEIIAVLIVRKQSFYEPIYTNIDEEEFKCYEDTVLFLICNFQTLIILVVVNRSKPFKHLVWKSPLYTVVIIICFVVSAYLLIYPDSLMRKIFEIYILGWKYKIILSLLILLDFMVEYILEKFILSKYFKKMKKCCYKKKKITRHQVIRQISLQSVKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCA3</accession>
    <name>A0A9Q0LCA3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Holocentric chromosome binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCA3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="807" mass="97601" checksum="2F941CA32C8ED3BC" modified="2023-09-13" version="1">MQEINSNLKIIMIWLSIPKNLIKNDQKTKVSIIFSNPKNKKFEKLIQQSEKTKEIWFLQFPINFQELEKEKELEKELEKKIIFHFKIKNGKEKKIKSFQYQIIIGNDQKNIIFEFFRFKEKPQKNDSNKIISKNIRDSVIINFMESIIFPKNPIQKKDILFTWQIILSLFQKKYPKNDELQKWLESNSQLENTPEQRVLLLSLLHYTFNPEIAQSLLFPQENNLEIIKEITMIIFDLFNTKSQENQNFQESFKNSINQISTSKMNEKENIKLIPYLLIFKKLNLIIQQEFTFKSSEELFHQIIILLNIALSHQNLHKYINQNLFISIFGQNYEFNQIWEEFIIKLVSGIDSYKETMNNFFKSLFPDHVFKIFAKTQFSNISNFIKFWFSFNKNFTQINKQNKSNENLPNLDNVFLNNFSIQRFIQSNEDFSNLNNFSTSNYFVNLNNFSNQETVSQYNDLSKEFKAKITSFLKKTYQKVDKKLIIDSKNILQFIPFDNIQFQIWKEFFKINVESRKNKEFEFIKLLPDFIKESEDQLQKISLTFKWYTNFKEVNKNFEPKTNKLTKLLEEYIKQLNEFKEKITSDNCSYKEFKLFTKYKNEYLQLFYSLSKKEIKLTQNEENYTKITWKLKLLENLIDFYLDRFKEFPQINYNNILDKIKQIKESNESMKDIIQSIDNLSIDFNLLEWIYNLQLSETFQNIWNSKIQKLTITINFEDIKNYISECSKEWKKLYKQIKKLEIKFSEIDFILPIQQDKNYLLNEIKFFNSNYQLQKNEENEENEENLKNILNLENKFSIFSVFGNFVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCK8</accession>
    <name>A0A9Q0LCK8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCK8"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF366">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="7">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="497"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="668"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="197"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="902" mass="105977" checksum="FC3B13CEEBB65911" modified="2023-09-13" version="1">MLKVGKKVKFGEKIGTIRYIGPTTFASGVWIGIELEQSEGTNNGSINGIQYFSSKEKHNNNNNNNDNNNNNNDLKKDNEEIEKIQNQQIEIQGIEDESNNPLSSLKQVVKKHEETFQKLIQERDHFKNQVEELNLKISQKGEEGKKFIENHKDWQKYFEIKKKSKELKNLVRYGKLEGQHLLYRIQEEKKKLDLTNEDILQKQIDDLKSEIQEARKLHNHYIEEQKRIDEELMFSGINLEVARSSIKTEIANVKKKIREKEREAMKKEFYRRRLISQINNNFSKEGIIEMRNKAKSLEIELKRTKKQIVEYERAQNQIQPTPLSEMPENKAQWIAAVMKKYPKVLEMRERLRPLQRSLTFGRLKNAAKTEARDALPKDSVIEIIMQYFKQEGYDPIVDYLVDKTGVPYKEPYFHDSGILDLLTLEIRDVSKIWDANLDGVQNPIAQEEIFEKPEDNPKFFQLDDDDVSIWDEPPDNPNNIRYDEELMAQLNDATQNYLNVILFANLNKLIEKLTYHHKLIDHKYEEAFLMTYQSFIKPEHLFFKLLQRMKIPENRPEILSKSRKLILTRVKHIFKVWLEKYPLDIPPKLLEHLKQVLHQHRSKDSTSQRIITLIDQITTSRKNPKVIDVPTSMRKIHKKKFQAPEPLEMEPRIPKNLFSHDLQLSHIDEVELARQMTLWNFAVFEKIEPSELVTQAWSKAKLKHKAPNVTKLIERFNLIVGYVAKEILTPPTAKGRSKQIIRFIKVAEALYELNNFNDLMAIVASLDSSGVKRLADSFSQVPANFINLFTKYKTLLSAEARYKTYREKLSSIRLTCIPYLGMYLSDIVYVSDGSPDKVDGLINFAKRKMLYNIIMEIQKFQQIPYNLTFIFQISVLFEKIELHTDKQLYSLSLEREPRASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD31</accession>
    <name>A0A9Q0LD31_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD31"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="624" mass="71250" checksum="D3DDF459D3E215A9" modified="2023-09-13" version="1">MMLFGDLLQYLLESTKINEDKIGINLDFFKFPNETELYYFQTFSTELRVSKKFKSDGIKNCKVTASAYSLDSSQNYGGNDLSLMEMKEYLKNQITISGDTIQYSDEDGFVKFSNLSISSGISQTINLTFFAECGIESENEFKKNGPSQNISLKSIYSNSTTAQISFPLSMKPTIDKFYFAKNESFNNEIFNFGKEILFIFGFSLSESSLKNQVYLNNISIFSIPANRTWIYPEYESYFFVNLTSSSFLSNALFPSIKIFNLLSGATSTKMNLTSFYEGKQMKIYDPSQNSYLSENYFNLNFETNVSKIEINENGSFIVKEGEIFSKPWEIIVKDNENKTIQNKPVFAKISKQCNFEISENQSPIENSKVLLNPISFTNEFGIATFSNLKFSISGLTKNNCQFKIKFISDGFFIETDNIQVNSSINKIIWIETVNSINITEDFKIISNDTWPVIQVQDEFGKGIPNKLISFNCSDFTFQPYQFITNQNGFVSLYLDFALILPNNFNYDYYSSNQTCSVIIDGIESETIQIKINANGWNNPNSSSISKIEIINWNENIKSGELINLNISIENHTGIVINENYNLTGFINPGDLPMGYLIYPEEGYWNIINGTGIIFNKNLWNFNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD55</accession>
    <name>A0A9Q0LD55_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gtpase-activating rap/ran-gap domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD55"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF65">
        <property type="entry name" value="RAPGAP_RANGAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="272"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="58450" checksum="3562879EE168553A" modified="2023-09-13" version="1">MELNSISSDKQKLLNENLNENLNENENLNENLNENQNLIQNQNQNQNQIQNQNQNQNQNQIQNQNQNQNQNQNQNQNQIQNQIEETDSNSDEKYEKLIQKNSNQKKNIEIKEKTKTKTKRNQIQKIKFPKEKDPEKEIELFTIKNSEWKQEEFNEEFDETDDENLDFKKKETIFTTHFEGKDYSCYATYHPNKKYMLFCIREITSNQNTFYKLLIFSKEDLKYDTINKTQIKKGCLRSTFCVSPSYKSVIQKTDDLLKNSNLIKCSCPAQDLLALENPTFHKEYKFGVIYVKPNQFTENEILSNNETSQEFETFLNLIGEKVELKTFEGYIGGLDKKYGSAGKYSIYTKWNDFEIMFHVSTLFPTFKNKSQQVEKKKHIGNDIVVLVFIEPNSIYNPEAMPSQQNHVLIGIQPVKIPKKRNIYFRIRTVSKSCVNEFLPKIPQNTLIPQHKLKDFLLTKAIQAEQTSLKSGIFKKRFQKYKKYKLKSLFLTKDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD77</accession>
    <name>A0A9Q0LD77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD77"/>
    <dbReference type="OMA" id="CDHTIDY"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="10"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="323" mass="35665" checksum="4E23DE202A27919C" modified="2023-09-13" version="1">MKAVVVKEYGDKEKLLIEQKEIPKPVSGQILVKNLVSGINLMDIFLRKGFMNPPLPFTPGSEAAGIVEAVPEDYKEEKFKVGTKVVYASMTSQTYAEYSLVPIDFLVAIPEKISFEDACAIPVQGLTAHYLCHSSYAVKKGDTVLIMAGSGGVGGLLVQMCHMIGATVITTVSSEEKMKIAKEFGADHVINYTVSDFKEEVRKIFPNGVDAVFDSVGKAVFDKALECLRMRGYYVVFGYASGQVENFDIMRLGSLGSLNLTVCMFTDFVNSPQIYQQKMADCLNWVQEGKIKPKVTTFPLEKVADAHEFMESRKSTGKILLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD96</accession>
    <name>A0A9Q0LD96_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fanconi anemia group d2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD96"/>
    <dbReference type="OMA" id="ITCIPEV"/>
    <dbReference type="OrthoDB" id="27031at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="822"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="871" mass="101392" checksum="AFEE69622191E6E5" modified="2023-09-13" version="1">MTQKQSQKNSNNIFNILGIKIKENGIQIKNETQFTNTLKTKLNQTKNFINEIIEKIEEIISKRKTFQKILLPVITTETNINHFAITQQSILRIMLQLNELQIPLTELLFSQLEYIYEEMEKKEASVFFDLIINQFVWLPQIFNPQKYSQLIFDKISNFPLDIQKIVINNLPKIIEDSQHFVAEQRLDNLMTKNPQVGVSVFQALSNFNLSEEVVENWKSRAVMLIDSMDISELPIVIHFLLHSSSGLKDANFEKLLMDLINKIDAKLTLITSTKNIQNLEKKNIIQDNKISKNIKEILEQVRIGARSNKKLSDLFLKSIKNIKSSEKLNIIHIWLLIIISELRIDKKQEVIRIIKNLIKKKIINSEKLQEMFIKINCTLIDDFTSIISLAELFLRNQIDIIAKFAQQLYFLCFSFFDDYFLKQEVVSSILTHISSQVEKEVDHAINTLVEISISLPDELAKFSLLIQAIFLPLSEMNQNQIRKTFQVLGILTSSKNVDKSLQDEIQMVLRKKVNSPKLEDKLNGILCGCSLLEQLSKEIILDNNNNNHHSLNSQLFSSPKNQINSTFDIIINAPRLEKLIQSFLFDEISFLFKNKKINILHNNDNSNERNEKDIYSNIISLINQEFSNILVSESKLNKMCKKYSESESNLLKDYSLWDSNEFTKEKKTKLIYPILFNLTTGDKQKQIELFTIPSLIRIYNSLFYSENEKSFIAEKLENLTIQLPSENIINTFYNLKNGEKTIVCISLFHAINLFREIINIYSSENVSTNIYLVKNIRFQLGKVLKLQSFLKRCLEQYLGFELQLFYDFTNLNLNNTQSNESQDSKKDSKKDSKKNPTPKMINVISQYYREITPQALFVMKHSSSNQRKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDC1</accession>
    <name>A0A9Q0LDC1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDC1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="347" mass="40762" checksum="7816C3B30960F06E" modified="2023-09-13" version="1">MIHNSESIPCIIGSTLGMFGALGFAVVYISFKAIRNFPRKLMFTLSIYDFLSSFVFILPGPLSSGLCKVQGYLLAYTFPTPSYWCLIVAIIFILKIYGWKYMELERFFIGAHIVMHIIEIIITSLFIAYATPRIGHTHWCWIKEIWLEAIIYSFYWAFLIGCLVFYSILIWKARKIKGQSDFEKGFQIKMFFIPILYVFTAIWTSWKRLREMIDPSVPNNEFLDFTQGLFVPTQGFWDFILFVVFDKEIRQEIRKKWFRCCCKPKIDDKDEDQDTENDLESTDISSDEKKAKEKEKEKERKKSQYYPTLPNQEMEIEMKSIDKESSSIEDLISHSGVDVKSIEQDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF04</accession>
    <name>A0A9Q0LF04_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_10155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF04"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05579">
        <property type="entry name" value="STKc_MAST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000604">
        <property type="entry name" value="AGC protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="621"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="788"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="799"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5071523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="818" mass="95467" checksum="5137858FEDBE70DB" modified="2023-09-13" version="1">MTSPTVTTNPKRMSRGYSQPLIFLNENEKLMLEESEPNSPKQEDSKTSIFSDDTMLKSFSTGNFQSKQIFQAQKDLLNQYQYQYQNQNENENENENETETETDTKTDTKTETLTENGNESENESESSFTQNQLTLSQNEPIFPIEEQLNENKRLNSDAHYPKAYPKAKTLSKSLKLKSTKTSKRTTSKNLNLHAYMIFKDYQKVDYKLKEARESCTKNLTRMIKQIEQEMKKKQENQDIFQKFVELKKIIGEILNLNEKSLSKQSWDRLVKKLDMIFKKSKREISYFVSSILFNTSKILRLISLSESFPPEFREIMKYSTKHVAIIRNGKPISPEKPIHRKKQTFSIEMSCPVAINNTLQGNTLNQEDGQSKQNKTSLSPTMDKDFKQFLIMKKALLNNQEAQSRIEEKQEKIKPKKPEKKDKKIVHLNSQEEIINDKLIESKKTDLEIPYLDPNIQQKDGQIIVCRICGRLVLSDMIEKHSGYCVIEQQSRSKIRYCDDTLQKFLVVPFSQSVYGKIDLENLIQNNLKIIVNCCLKINLNSESAVIKLKKLLEQIQVHIGYGKKKKCHLPRDINEIQKIFLQKIESFEKVFQTSPNANLTAVYGSETNANLYNIHSLQSFEFIKLISRGAYGKVFLAQSKTTRDIFAIKVLRKNDMIQKNQTEHIKTEKNILTRTVNDFVVKLFYSFQTKKYLYLVMEYMNGGDLYSLLKNVGYLSEKMAKFYLSEIILAIEYIHSKNIVHRDLKPDNVLIGNDGHLKLTDFGLSRIGIYERQEFDELDRVNEGRYEQYKNENEIENENQNQNENENQNENQNRKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF15</accession>
    <name>A0A9Q0LF15_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF15"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="26"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="296"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="489" mass="56613" checksum="9C979712CF47ADC4" modified="2023-09-13" version="1">MSKNFVNYEKLSSDLNTLFSNPNEFADFEIEILDSTGKTTHNFSCNKSILSCRNDYFQALFRSKMKEFQESKVKFNDINGKSMEIILKYIYTGILEIDPENAIQTLIDSKKLLLEDPITIFLINFIKNHLDIWNVIDVLYLANELMIYDLADDCLNFIYENLILLNQSNEIVKLEEENFLKILKKDTFSISEMELFNMIIKWADYHLSIPNNIVDNKKNSEKISQKIGNLIHQISFCFMEESEIEQIQSMNVVPQMYIDDVIQFQRQNGDCPDLIKKYQEMGSKILEEPNQLRKSEILQGSNKYLKALSRWINSPSFLSKVRLGFSAKKNGFMPSDFHSHCDNKGATVVIILTKNGFIFGGFTKVGWTNDKNKWRSEDSSNASGWIPDPDAFVFSLKNHLNHDPVKFPLISSESLNAIYYSDMDGPSFGKSNGFDIGIRGNNFYDCWSYLGNTYSVLEKFGSNKYTNDSKNFFAGKYKWEIEEMEVFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFY2</accession>
    <name>A0A9Q0LFY2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Folate receptor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5071986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFY2"/>
    <dbReference type="OrthoDB" id="5982264at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="331" mass="37840" checksum="E355C89C6DA327AB" modified="2023-09-13" version="1">MTDKNKETKPLINNEKANEIDSQPKLESNLPFIDGQPLEKQPLYPPQPRLQQQQPYLQQPYYQQPYYQQPYYQQPYYQQPFTQTIQQQQQQIDYPTVGINTHRKSSKRPGYVRPRNYVICIVCILVCIGIITLIIVAIASSFKFKWDNNSYPYNGNGVPGLTCPARSYYLTKSGNNNIGECVFYDYTCARDDTVFDLSRDYSQIFTGEDYDSDCLSNLGYLQCAPMSPYINSFGSNIQIGENYQNFILCDFFCDTLYDNCKDATFDCSSNNPFPHVYCGQTVSSQFSDSKSFCQQGLYLTVSSDQNSCFAGVGSLIPSILILAFLSLFFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGB3</accession>
    <name>A0A9Q0LGB3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xanthine/uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGB3"/>
    <dbReference type="OMA" id="PDAMGMV"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="534" mass="59237" checksum="CC007FCB0FD3C316" modified="2023-09-13" version="1">MTTINTLNEIPMDDLKEEERKEMERKEMEKKEKEKKDKKKDSGSVSTFSDSNSGKENEPDKQKAPNDPNQEFSPQYYQEAEFVSPYNNPFLVFVDKYFNISKRNSNFTTEILAGITLFLTTSYILQKQTTILGIAGMDSQSVFTATALTTGLGTITIGLVSGFPMLISTGMGENFFFVDTICHTLGYDWKIGLSLVFFHGIISVILSIVIPKSNLIYAIPSTFRIGIAYGIGLLIGKIGIIDMLLLDTSSHFDPKYQALIGGLTLVLIVYGASRNHKLVVVLGVIGSVVLSIIISIARKDLSFPKWVTPSLKETAFKLKFDYRNAVPIYYVIVYVLNTLFDVVCSSLTIIQLTFLSKIKYDNESFVKLVAGAKNNRFMKILLVNSAFVIVSSLLGTSPTVIFIESCVAAALGARTGLCSIVAGLLFIISIFFYPIMMIIPQESIGPLLVWTTISVLQMVEYMNFDDINEMIPVAISSVLIPLLDSVIYGVSSGYIVLLLVWITGKNRKWKQINATMIFVGIASIICLFIPKTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGN4</accession>
    <name>A0A9Q0LGN4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_01422</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGN4"/>
    <dbReference type="OMA" id="MESVMTC"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5072408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="474" mass="53143" checksum="617015E610C43858" modified="2023-09-13" version="1">MREIIHVQVGQCGNQIGWKFWETICQEHGINPDGQYEGDNELQLERIGVYFTEATGARYVPRAVLVDLEQGVMDSIRGSKMGKLFKPDTMVYGQSGAGNNWAKGHYTEGAELIENVMEVIRKESENCDCLQGFQISHSLGGGTGSGLGTLLLSRIREEHPDRMIATFSVVPSPKVSDTVVEPYNATLSVHQLVENADEVMCIDNEALYRISTNTLNIPNPSYPDLNHLVSSVMSGITSTLRFPGQLNSDLRKLAVNLIPFPRLHFFLIGFAPLTRRDAIGYTALSVPELTQQMFSPKNMMAAADPSLGKYLTASAMFRGRIPTKEIDDNMLSLQNKYQGQFIEWIPNNIKSTICDIPPKGHKISVTFIGNSTSIQELFKRIEGQFTKMYRRRAFVHWYLGEGMDESEFAESQNNMKDLVKEYQQYQDATLDDVFGEEDEQDEVDSQEEVQSGQEQVSGDDDDDAQVDDDGEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGN9</accession>
    <name>A0A9Q0LGN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGN9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="91" mass="10618" checksum="3109FC9FC2BD2F5F" modified="2023-09-13" version="1">MDFLLQKWHEKYHKENAIYYDLKRGPCFGGDLYGIGIPDFYLNSKLQAEGSNLGYSYNLPNGIIYKTNEAKSYLAGSKNKWIVDEFETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIG0</accession>
    <name>A0A9Q0LIG0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIG0"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="3">
        <location>
            <begin position="548"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="917" mass="103394" checksum="50679D2152BB0109" modified="2023-09-13" version="1">MATINQNLINFIIHKYPDFVPKKLFDSHTNKTSFLKKSNKDDLNTIEITQFIQKQLIQFFKELKNAKPNDQVNEILQIIPCLKANVANTTSVEIIGQKLLFEFLQQNLPPISEKFYKKLINLDHIVITQQLFGNMIQAQMPDSILWLLESEQFSLQKGRCLVSHFPEITKEILQLFEGPNCSRFFSIISSRVSRNGSLLEFTEKIIRGKPLDQKYLISFLLSQIKTRRSLEIEVGNLRESQFINKNPIQNPIQNPIQNPIQIQNPKSNPKIKSKKINPKKKSIKKTQSKKTQIQTKSKKMQENPLARSMFSYVFDLKTKNVTTFYKILVLTSENDEKYHKNFCSTLSSLNFEDITVLNGGDQIKIEGDYLQQFHCIFVYSVVDFSDPKYFGDLIADYIEKGGGVVFAAFSMDEPKMGFSGRIISDQMLPVVSSGRDTNPSHHQMGKVLVDSSPIISNVKNFDGGLKCPRHNLVCLKDSLLIAEWDDGQPLIVQRDFKSHNGLIVVLNFFPISSDFNPDYWDSQTDGGLIIANAIRHCSTNFVFANISYTNCGSDNDPATLTYFSYLPADSFVIDSIFSYVANYSIKTGYEISTGSTLHLAVWYQNFSADPIIEMDFDSCEIFSCPVVAGNYVRKDYDIKVPEFPIGKYKIELLLRDDQGSRLACYDFEASMSNGSSPTPANCVYTSSYTFSTTVAQGQAHYQNEAPADRNIGDWMQIGNMSSHGTFPLISFSKLDSTPDNTFGETLEPSNFQWAINATYNTDNSNSNEYIFEYSGDFWMGSLQLGMTTWDNFTSYPNNWAGPISFGKVNPASIQFDTNYRSVVISASKDFCQCEVDICGVCGGDGSSCQSPTSKSESTSKVGVIVPAVVVPIVVVGAIIFVVIYHKKRKQKQLRDSVMNPNIPSYNTSDWTKIGDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIV9</accession>
    <name>A0A9Q0LIV9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIV9"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="233"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="338" mass="39928" checksum="A949E9D7EE9FDE77" modified="2023-09-13" version="1">MKIKIENPKRKLYSCGNSVFNGLDKDGHTYEFTEIKSSLFENDDNIIDFSVGNNHTLILTSNSKLFSFGYNLFGQLGTGNTKEYQSIPIQIEIPELRFNEDISNYHISCGHDKSFLYSPSFSNLEEDLIKLFGRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSIINPKLYSEIKEIINLNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ59</accession>
    <name>A0A9Q0LJ59_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ59"/>
    <dbReference type="OMA" id="KCCCSIF"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="182" mass="20548" checksum="9C606659DEAFF79D" modified="2023-09-13" version="1">MEQLVKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLISPSSFENVRAKWVPEIHHHCSNVPMILVGTKLDLRDDQDTIMKLEEKGLSPISYQAGMDMAKEIKAVKYLECSALTQKNLKTVFDESIRAVLSPVKPDKPKKKCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ79</accession>
    <name>A0A9Q0LJ79_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ79"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="422" mass="48716" checksum="BCF8AF160DC84499" modified="2023-09-13" version="1">MNEILFFGLNNFPIIFKNEPNAITKPIQFKFENENENEKQIKQISSSYFSTIFLFKNGKAIEYLNENDSKQNPSKIQIKNIQKVTVGYQNEAILTKEGNVFAKGYDINSNNPKEFINISSLIKDPNNRIIEDIVSGSNSIYLLTSNQNAYGIGLNQFGQLGLDYETLKKTKKPILMMKNVSKIFSGTDSLHVFLLNSNQELFGCGDNEYGQLGLGESINEIKIRKLTKIQNIPKGKIIDIQCGSFHSIMLIEDENQNQNQNSKRKLYSCGHNRYNGLGKYEDTCEFTEIKSTLFENDDNILGNANTDDGFKPIQIELPKLRFNEEISNYHVSCGYRKSFLYYSLSSFSNLEEDLIKLFKRKEFCDISFKTKNGEIIEAHKLILKYRLKDYENQIEKLQEIISKNQLKNQIKYLKLFIQTIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJF5</accession>
    <name>A0A9Q0LJF5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJF5"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052121">
        <property type="entry name" value="F-box_SCF_Substrate_Recog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550:SF1">
        <property type="entry name" value="F-BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="463" mass="55880" checksum="77A3FBB375C1FCC0" modified="2023-09-13" version="1">MEQFTIQKFGDKLKAKITNDNFNFLKIGEMSEVPTKLKKPPKQENLFIEMLPEDVHLYIFQFLSPGSLLKLSMTCQTFNDLSKDINCWRNMSFKYWRYFLLNDLEMQNNFYYYGNSKEDQIPIYGIIEEPKIINSNLQSIMDKKPQKLIQRQSSISLMFNRLKNLREKKEEDQNYIFPENDYKSYMMRYIQSIPNPGNELISKSKLINQKIKERKNRFEEFKKNQMEINRRILIFQKIDTWIDIDIQVFKFCILTFLILLGFYIDTNLSFNPFYFFILLLIPTLILPILFLFRSFYDTQNNKKLYFIVSLITFVIFIQVLLIGLKSGKIIQYSWLFRKIFRYFLFVILSLMTFLFIIVLEMKLDGKIGLSDFKVFFLLFFIGFFSIFFWAISKTQHMIRGVKLVFGFIFMLYLVPFTIFEILIFCYLQFSGFEYISFTFIPLYLFLCCQPFPSHKDFQDLDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJG3</accession>
    <name>A0A9Q0LJG3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N(Alpha)-acetyltransferase 10 nata catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJG3"/>
    <dbReference type="OMA" id="MSMQNAN"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000037">
        <property type="entry name" value="N-alpha-acetyltransferase daf-31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="231" mass="26765" checksum="8F86E3C49164B266" modified="2023-09-13" version="1">MVSIRNATIDDLFAMQNTNLHCLPENYQMKYYYYHLLSWPQISFVAVDSKNKVVGYVLAKMDDEYVDKTPHGHITSLAINRHYRKLGIATKLMKQAEKAMETVFGAKYVSLHVRESNRAALGLYAGVLKFEKHKVEEGYYADGENAFEMRKFLDQKVAEEYKKEQEEKEKEKEKEKEKEKQIQIEKQIQIEKQKQTQNPQKKKNQQRKGKGKGKGKGKGKGKGKGKGKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJR7</accession>
    <name>A0A9Q0LJR7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJR7"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="263"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="435"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="472"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="663"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="810"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="844"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="877"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="910" mass="104020" checksum="A6726CC74D9B8AA9" modified="2023-09-13" version="1">MFKSLIEKGVDINSKTKKRKTLLHLVCKYQQENSLEIIKFLVEKKAKLNIKALYLEETPLHFACIYKHSNSFELIKFLVEKGADINSKTNNKETPLHFACKYENSFEVIKLLIEKGVDVNSKTNENETPLHYACQYQNSVDVIKFLVEKGADIFEKGNFMQTPFRYAFQYQNSVDVIKFLIEKASDINPKKITTEKAFHYACRNTNPNALEIIKFLVDQGIDINSQTDLQEVPLHYACKYQNSFEVIKFLVEKGANIYSETAQKQTSLHYASQNTNPNALEIIKFFVDQGIDINSKANQNQTPLDFACEYQNSLEVIKFLIEKGADVNAFTTYELTPLHYACEYQNSFEVIKFLVEKGANVNARTNWEGTPLHFACHYKNSFEIIKFLIEKGADINSKNKYFITPLHYACEHQNSLEVIKFLIEKGANIKAQTEYQLTPLHFICKCDHPNSFELAKLLVEKGAELDVEIAQDHMTPLLFACQHKGSNSFEVIKLLVEKGANIKAQKKGDKKTSLHLACENINANSTKIVQFLVEKGADINAKSSSVEIPLHTACFSLFNCEKIQTCVEVIKFLIAKGADINAKNFEDKTPLLVICSYPNEYTVGLINLLVSKRADINAQIRNMKNTALHIICQNDFSCPKETLFKIIKCLVENLADINIVNYHSYLPLHYACTRLISLEIIRYLVERGSDVNAETIFQETPLYFICFNQSQKDEPSIFDIIKFLVEKGADINPKTNINQIPLHYACQNSSFEIIKYLIEKGADINSKNSRNETALCFALLRFSFGIKDTIEVFSFLINKGADVNIKFDYKNDSILHFACKYKNPFEIIKFLLEKGIDINSKNDRNETPLHYACQNSSFEIIKYLIEKGADINSKNNGNETPLHYICKYKNSLEIIKYLVEKGADINSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK80</accession>
    <name>A0A9Q0LK80_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase brsk2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK80"/>
    <dbReference type="OMA" id="NDDIANH"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5074020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="583" mass="68061" checksum="A7BAD1422B3CBFEF" modified="2023-09-13" version="1">MIGPYKLLQTLGTGSTGKVKLAINTETEKQVAVKIMPKKLVFATEKARINAQKEIAVLKLLNHPSVLKVFDVFESDEYLFMVMEYMPGGELFDFLVNQEFISTKQSLIFFQQLIYALEYCHNHLVCHRDLKPENILLDSFGNIKIADFGMAGLINERQLLETSCDIWSCGVILYVFLVGRLPFEGESIKDVLMKVLEAKYTIPENLAPAKKELIKGILEKDVNKRFTIEQIKQNEWFRSNFPTNYNPPHAILRQRFIKPIPENKINQSIVGNLTTLVTDKEQILRSLTSDQPNLEKIMYTLYMRKVKKRYKTESRKTGLKSSSPENSDNSNESQEENHKNDNNSNNRNNSNSNSNSNNNSKKELRQKKKEEKQSKKEEQRKKKDEQKKIKENKKAQKKKVRYSKDDLGRNKTSSKVKISIKRKNKKSEQFDLSFDLEKETNKTKKSWFGKLFKRKFKKKKTKEEKKYQKLHLDNKFEQGGEIFLKDPTEKLAKNYYVSFSINQPIMEIMRNFQEGLTKLNFNWAYPNIFTIKANFNKMKTKIKLPNGPILINKEPIKIYLISKRGTAQEFIEFCNSLIKVSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKF0</accession>
    <name>A0A9Q0LKF0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycogen synthase kinase-3 alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKF0"/>
    <dbReference type="OMA" id="TKMATGR"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5074537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="392" mass="45600" checksum="7641523F039237B2" modified="2023-09-13" version="1">MSNSKITHSSPKYRATKKIAKGTFGIVYQACVIQTNEIVAIKKVLQDPNYKNRELSIMKLLDHFNIVKMNDFFYTTDNNCRSKHSEKNKQDVYLNLVLEHIPQTIHYFSKQFFQQRKQIPLTWIKLCDFGSAKILIKGEPNIAYICSRFYRAPELILGSTDYTTSIDLWSCGCIIAELFIGKPLFVGENSMMQFLEIIRVLGTPTKKQIEKMNPNSITSRLPQFTKQKFSKIFPKDTPNEAIDLISKLLKYSPQKRIHPLPACAHSFFDDLRDPNSRLPNGNALPPLFNFTEQETKGLSDEIILKLNPQKNSLSNNFQQKDNSNELEKLKGNIIQETQNNHKIIEKENNHKKNEKENEKEKEKEKEKEKSKNSNQKIQQKKKKGFFAFFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLD4</accession>
    <name>A0A9Q0LLD4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanine nucleotide-binding protein g(O) subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_07191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLD4"/>
    <dbReference type="OMA" id="QVIWADA"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="265"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5075621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="347" mass="40231" checksum="39FB631517586D11" modified="2023-09-13" version="1">MGCSDSKVDNGKKRNSEIEESLKKDKISQGNEYKFLLLGAGDSGKSTILKQIKILFQSGFTEEEKKDYIKIVHSNILESMQALIEKKQILQLSFQNESNEQVSSSILSLTGDQILSQEIGSMLKSLWNDKTIQEIYTKRNEIQMCDSAKYFFEDIDRIFDPDYVPTEDDVIHSRTRSTGIIEQKFVLQGLNFNIVDVGGQRNERKKWIHCFHEISGVIFFISLSEFDQKLFEDSQENRLSESIFLFEEICNSRWFKKSSIFLFLNKIDLFNEKIEQNGLSEHFPDYTGGKDPKAARKFLRKKILDANNNPNREIHTFYTCATDTENISKVFNKVKDLILKQTMNNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLK5</accession>
    <name>A0A9Q0LLK5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress response protein nst1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLK5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="681" mass="82314" checksum="F74BB0660D346268" modified="2023-09-13" version="1">MEIFQFSLKIDPNNSTPPCTVKKKINTNQDFELLKLILSDVPILQKLIYCRYDLSTSHCESFFSVLNLYRSKLTHSGNYPLLYKLASLDWNYNRTRQKSDLEKEQERQNENNQNNENNENNENNENNQNNENNENNQNNENNENDENNENNQNNENNKNNENNENNQNNENNENNKNNENNENNQNNENNENNQNNENQVKYKVEIEFGEEISQYHESQNEDEDEDEDEDEDEDEDEDEESFSNKNKKNRRKKKDMNWQKILLHQSLPEIFQIDEPSNQKEVEKSNFNSNSPKEKKKRTKKRRNCKSETKLKPKRPKTKTKTKKRETQSNGKKKKEPITKIRSKMNPRLIDFANEKKRNRTRREVFPLQKMLQNYPYQEEIRRNRSEIDDFLNHLINEPTPIQLTYEIHEAWWERWDINGWLEFEDISIVLRFLFQDQYHLDPDWTKLILDPTMRKFSAGYRNLQEFENQQAEDRKNFDQFLEKTQQTLPNLIEIKKNGWKREVFENMEECKRILRFDQDKNKSPVPLIWWYVNHYVCFIVDHNKNQILQFNSFPQCWKEEVANFGERITFFMEGVTNRKFERIVLDTTNLQIDRAQCGIFVLLFLWLVLTWGMPIEKCLQVMNHWLALRFRLMILVQILNKKKIPIYLKPQNQIETLMANHPWGKKRVSFFLKPQSTITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLV5</accession>
    <name>A0A9Q0LLV5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLV5"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="469"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="586" mass="68130" checksum="9D2A14B250DC8690" modified="2023-09-13" version="1">MNEILFFGLNNYPILIKNKPNEITKPIQFKFENENENENENENEKQIKQISSGFFGTIFLFKNGKAIEYLNEEDSKQNPEKIQIENIQKVTVGEKNEAILTKEGNVFAKGRDINSENPKEFINISSLIEDKNDRIIEDVVSGAKSIYLLTSNQNVYGIGSNTDGQLGFDSKTLPKTEKPILMMKNVSKVFSGNSSHHVFLLNSNQELFGCGYNQYGQLGLGKSRKDKKIQKLTKIQNIPKGKIIDIQCGDNHSIMLIGNEDQKRKLYSTGDYKYSGLGKGEYTYEFTEIKSSLFENDDILDFSVGNAHTLILTINGMLIAFGYNKFGQLGTGDTEDQSIPIQIELPKLRFNENISDYHLSYLIKLFRRKEFCNISFKTEDEEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSITDNKSNKVIDYSELSNKSFQIFEYWIYSNQIKDEIQITQGIIDEIKRGIDYFQLNQTNPNLFDLLIKKFNNQNQNNNSKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMP1</accession>
    <name>A0A9Q0LMP1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMP1"/>
    <dbReference type="OMA" id="IYSVRFM"/>
    <dbReference type="OrthoDB" id="10264491at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019198">
        <property type="entry name" value="Beta_propeller_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014441">
        <property type="entry name" value="UCP006425_b-propeller"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09826">
        <property type="entry name" value="Beta_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006425">
        <property type="entry name" value="UCP006425_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="574" mass="66335" checksum="39F8B3FD1D53EF5F" modified="2023-09-13" version="1">MNTGFAMKESSGSSESSGSSAPSRFSKTNVQVQGIDEPDIIKTDGENIYAVSNGKVYVLKSFPVSDSKIISKIESDHFFPLNIFNYKDLIVVIGMKEQPKEERKKINEKIAYNYYDYNWENHLQIRIYNVSDKENPKIEQVIQIPKSHYIDARLYDDEIVVVSKKYLHFRSTHEDEDEDIFHKNNFPEHQFSEIGKEDIDEKNPENFQLQCQDIGALSKTDNRFMITLTKIKLGNQSILKKSFPLETFSFLAGENQIFSSSEYMYLTSSNSRYKVEDDQYIDYSIVHQIDLKNLRYNGFLSVPGYIHDQFSMDEYQNTFRIATTARTFRTFPYHSSSAVHIFDTKTLELQGKITNLAPNETIYSARFMKEKLFLVTFQKVDPLFVIDLHDPKNPTVLGKLKIPGYSDYLHPINEDGSKLLGIGKDTFSPENSDTAFYLGVKLSYFDCSNFTDPKEMFNIVIGSRGTDTPISRNDHKAFLFDPENSLVILPISLYETGEKYQRSFPSYNDFVGNFLYVLKIDEPNEFTIKGRISHENEQILRALYIDDFLISFSGTKLKIHSIEDIKFIKEIILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNJ3</accession>
    <name>A0A9Q0LNJ3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_07219</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNJ3"/>
    <dbReference type="OMA" id="LLMEYMA"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000592">
        <property type="entry name" value="CAMK family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="493" mass="57331" checksum="B10FE22FFBE0CF58" modified="2023-09-13" version="1">MKINPHFFFSMFSSKNLLQDYVFQKTLGIGSFAKVKLATHIPTNCEVAIKIMKQDLIAQNKKNQERLKREIQILKSLQHQHVIQLFEIIETKKKIYLVMEYVKGGELLELIQKKGKIQEHEARKIIIQVASGLSYCHQMGIVHRDIKPENLLLDGDGNVVIIDFGLSNFFQKDELFKTACGSPIYSPPEILLGEEYPGEKVDIWSMGIVLYTLVCGKSPFAGENIRAVCDNILHQKVQFPSFISRELEDLLTQILEKNPVLRATMPEILSHPWIQYEKELCNFEFKQNNCNSQEMDDPVISSQLSQMGVSLKSVKESLHEQKFDSAMAKYLIVKKNKKKLQRRLKRKACENSTTINTSSQQEKDKDPNNKKVTSESFQDEEYKRNRITTTNSKQRNYLFECLIPKIITISKCSSKPFDEIIKEIRKKTEEISLRYTQNSISSFQCENDLVKFDIQISKIVCDNNFYLIQFIQKEGNFIEFEKIWKELFFCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNL5</accession>
    <name>A0A9Q0LNL5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mediator of RNA polymerase ii transcription subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNL5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="391"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="635"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="800" mass="99382" checksum="40BF448F8260B3AC" modified="2023-09-13" version="1">MPQIIAYNLKHLSESEIVHLFEQFGTITRLVIENESRPFTIIEYQSLEQCDLAINSLNKKEINGEVIEVIYEGEEHRNYENALITTEINPTEEYEEYKEYKEYKEYKEYRPISPTEIEYEKNQYNYQQYENQNTYQPLDNAYTDSYNPFHSEFNDLQYQEKIYNKVYDDQQLQDPNDPQQMDHYPNNDDYDHRHHFEREEVRDKETHPHTHNYDHTRRRYQERGNPRNHQIYGDTYDIRDEYNYPHRNDNRFSNRYNHRNEQRNYNAHPLRENTHYRRNRNNRDVYIPQFHERGDHYEINHKYSERKDDPNYVEPKKYDESRYSPENSRKEEEERIRKEEIERRRREEEERIRKEEIERRRREEQIKKEKYHDIYSDKYYDKYHNNKYHDKYHNHKYHDEYRNRQYKPRVYHDYYSREDELREREREREREKYQYQIEREKQNEKDKYYYSNEKDQNRNYNSHTDYIENDYSRVYQKSPNTHSSKEHSRHHSFERRDSHSNFLQEKETRNYSLSPSPNHNIYDNSSFKTSFIDKNVDFHDSKSNIQEDYQNQNQNLNQNQNLNLNSNPNQNQILNQNQNQNLNQNQNQNLNQNENTPTNVSNSPSKSKIISTLPEFDSRERKLKRLNKFNDIQPKSNLEQKNINQQNQIKNQNENQNQIQNQIQNQIQNQIQNQNQNQNQIQNQNQIQNQIQFQNQNQYKQNQNQYKNQNQFKNQNQNQNQNQNQNQYKQNFNNSQRKSFEARKIENQEIVVRSRNQEFLPHKNFQHGQNFDVQRKRAIQQIEISITPNLGIQKKRNYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNM8</accession>
    <name>A0A9Q0LNM8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNM8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="619" mass="73704" checksum="46F3E2D9199273E2" modified="2023-09-13" version="1">MFNSFSQNSISSHNTLSRYLRKNRLAVENKIKKEEKEEKEENEEKEEEKEKEFLLEMKDFLIDPTNKGWTTTRTRKPKNMNQNMNQNINQNVNQNINQNTNNPINTQHKNQDEEKQHQHHHPFFSTSFVKPEYYSLRAKARDEIKFKFEKLLNITTLDDNPKTQKETQDNILPVKKDDSLQNQSNPSIYHHERRRAQSTKETFNENPINFQTENIQNNSKFENQNQNQNQNQNQNQNQNQNQNQNQNQNQIEEKQPKNLSPFKKSPLFHQGNQNKGFPNQRRKTETNLKTQFDPSYKFNANPNLKKREITSRQKQISPFEDHSKPRTKSTTTKRINSPNSLLPNKAKSPKDLSNSNARKPQLKPQVKSKSPNSRSPKNSFQNENPHLHSQVSPKLNRKAQEKSPKSLIKKEGLNFEQKNFPNKQEDRKNNNLREFERNPNLNQSKPFSPYKFDIDDDSKEIKIIETDKNQDQNQNQPKSFSPTKPINKNDQLKEIQRIEREIEKNEANKRDQNQNQSKPFSPTKSINKNDQLKEIQRIEREIKRNESKTKEVQIKINQNHFHHINLILMMIQKKLKSLKQIKIKIKIKFKELKEKLKKMKQTKEIKIKINQNHFHQLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP75</accession>
    <name>A0A9Q0LP75_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP75"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="111" mass="12375" checksum="07B9838469BE4395" modified="2023-09-13" version="1">MTSSVTVAQATTIIYGIIIGIYGFIVSLVHKTTKAGLVMSVIGISVFIIVLTILLIKFRGGVFILSMVLLLLFVGSLLLSVLQKLKFKVLQNQVFSYYFFFFKIAKDKNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPA0</accession>
    <name>A0A9Q0LPA0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPA0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="157" mass="18917" checksum="598EF9013E5E7973" modified="2023-09-13" version="1">MLNLPKILNQGIYSNHIRSKSQNLIFDKKFQDKIISSEFISRDAKADFTYNLLLKKMQIEKNKKIQEKILLRIINFKIKQKLCSSSSLLFHDPHQDQKREKERKLKIQNLRKAENLKERLRSQNQNLKKINLIKNKINLIKKKLKKNKLDFDFDFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPH7</accession>
    <name>A0A9Q0LPH7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPH7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS fold" evidence="2">
        <location>
            <begin position="11"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="247" mass="28834" checksum="9E798AF11F2C21DE" modified="2023-09-13" version="1">MGNIDPIAKKKYQKRIKNSDKAILVISTSGDIFAVNKATVKLFKGISRKDFMKKRTVELAPEEQSHIGKTSFEYGFEMLQDLWRNHKESLEGEFQFKDFEGKIFWSKVQARKLSFGGDQPLIEMTIIPIEKMSKNQVTFQSKKAIKSNSKIEINQEFKNQKIGIQSKDSLMNSNENTNSLIQKISDQIQNLNMQKKLLQLSQLEEFIRTKVVEKQKEEEQLIEKLSQIKEEITNLENEYEKTEFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQZ3</accession>
    <name>A0A9Q0LQZ3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_00259</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQZ3"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5076939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="413" mass="47504" checksum="823A50E6F34D180D" modified="2023-09-13" version="1">MSNKDNLPKENEKEKEKEKENKIEEKEEEVKQVVTTTKVVAGKEGVDYVKIVEEFGMQLITDPMIEKMGKLSKTPLHHWIKRGLFFSHRNLDQLLDKYEKGEPFYLYTGRGPSSESMHLGHLIPFMMTKWLQDAFGCPCVIQLTDDEKFLWNPKLTLEKVHQFMIENAKDIIACGFDPEKTFIFSDMNYIGEMYPNICKIRKILTFNQVRSTFGFTKSSNIGQIAFSAVQAAPAFSSSFPKLFADKKKVNCLIPCAVDQDPYFRLTRDIAPKLKEKKPSLMCSKFIPSLLGLNEKMSSSNPNSAIFLTDTPNQIRNKINKYAFSGGGDTIEEHRKNGANLKVDIPFHYLKIFHPDQERIEQIRKDYGSGQMLTGEVKKELISILQDIVKKHQENRKAITDEVLQKFMTPRQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR41</accession>
    <name>A0A9Q0LR41_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR41"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="127" mass="15522" checksum="2C314366DEB6555D" modified="2023-09-13" version="1">MKKLEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITKEIIEELKIGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSA4</accession>
    <name>A0A9Q0LSA4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSA4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="551" mass="64216" checksum="D576C88C34230DB1" modified="2023-09-13" version="1">MNDCLFFGQNEYPILIKNEPDKITKPIQFKFENKNENENEKEKQIKQISSVTASNWNEAILTIEGNVFAKGKEINQENTKEFINISSLIEDTNDRTIQDIVSGSFSIYLLTSNQNVYGIGSNQDDQVVFDSKTLKATQKPILMMKNVSKIFSGNSSSFVFLLNSNQELFGCGYNFYGQVGLGIKETKIKKLTKIQNIPKGKIIDIQCGYSHSIMLIENENENENPKRKLYSCGYHQYSGLNAFDYTYEFTEIKSSLFENDDNILEISCGFEHTLILTSNKKMIIFGDNDFGQLGTGDTKNQPIPIQIELPKLRFNEDISNYHVSCGAFRSFLYYSLPSFSNLEEDLIKLFQRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQNEKLQEIISNKSIKESNQIFEMIYSNRIINPILYSEIKEIINLNEKIEETMKRIYLNENEKEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIEITQEIIEEIQIGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSD9</accession>
    <name>A0A9Q0LSD9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF100">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="892"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="1411"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1531" mass="172887" checksum="9A1409F20F97B44A" modified="2023-09-13" version="1">MAQESTEQIKDIITRNGEEISLQLNALMKKGNKQVEVHFVLTNFQIYSVKVKKKLKEKQIISTKGNHFYNLKSIFSQDNLHIIEQYNKISRGIPKQNHFKFEIRPEKRDTRLRAEIYTKFEENVTPGHGYIDIYRAYCFLYKIPQSRIFIQYVEANLKKRTSRTLNLSNFQGIEVESKNPLYINLKPVLCGLKYNTWFHELRLENVNRKEAIGMVIDVLTENRVLTTVSISGLPNEGLGQIGGVFEANGNSSLQNLDLSKINITDKLACVIGKCLSHKKNGLTSLRISHCNLSKAGSASLFGMLKESSEFCGKIKQLHCSHNNLKAEGGEEFVALLKAVLLNNNQLTHLSVGSTGVPLEGLLSHLTNFYDTLTLLDLSGNDINQGAASTLLCKLVESSFLLRNLDMSSTSLGINQLERVLHSLCKNKNIEKLELNLSTNGLGVRGAEIISTMLFHAKQLESLVLNENELKDDGMSLIVASMIGQPTLRRLSLARNIRAGEQCPKTKTQLELFAKGNRSVVWMDLSGDEKNFALGENLHGFLTELANQTAIQTLDLQWNDLRDNGIQVLCAALKKNKSVKSLKLDHNNISISGLEAFNYALFENDTLCDAPFPEDDVKRFARKKTEDMLGVLRSSISQKLEQNRIRRSVNTDLRKKKKIDLLRSFNRDHPRIKDKITSLDGFSLIRGVSQLEEEDNQALLVGAMHPRSRHLSIKDGRTRSSSTRKNMLSGREVPSLGRRISTNQPLAFTPPPRLHSQTIQRRYSHHSSKTRVREPSLREPSLFSMELAGIAAQAQNQLKQDSEKRMMQTQVEDIDLGDMEDMSDAAKSALSVRGTAAISRLLKTKKLDLSRIRDKDSFSTALHYVCDLGDPELLSFVLSQENCPRLINARDNIGYTPLHRLMRTGLSTDCITLLVDYGANIEARDKSGWSPLQVCVAFYERPLENSNENIFISKEKDPVMEKKYQIERSPLDEKNTPLKNVFRQPTDTPSRQRMLALQTLLQKGANPNAQDLKAWTPLHRAALKGFSSAISILLGFGADTDSADSNDSTPLHKCARNGHADCVKILLDHGAMANLKDNNGQTPLDLALIYNQELCVELLRGVTDTGTTGETEIEQELSSETSSRLSETETTNQTDSLSSLINPTSIRIEVLDRIPDFDGKFFAPTFSPSRIFNICIVGTQGSGKTTLARRFMTGVFPESAPSPFEIEAKHRKIVLINSIEMILNIVDVSGAEIYLPFLKKFIHASDGFILACSSADDPKTTALLESEFLPMIQNEKTGVERVPVVIATLKSDLTDEDSREKTFNSPQENARALAEKHHYPYFDVSSKNNKNVPNVFISIAQEMYRIYNRAAAIEKEERKRVNQREKDLPLIQKRREERIEKRKQNNPEITLNSQSQKPQTPDNSDLLENRFPFTKIITHSDLVVEFENFLRHQFADENLLFYYSVQKWKSIPQEESGLLSLAAKKILEEFISTNSYVTINISGKCRDSIEKKIRALNFNRDLFDEAVEQVLVLLKNNYYFAFLEVMKTQNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSL3</accession>
    <name>A0A9Q0LSL3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dymeclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_05213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dymeclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSL3"/>
    <dbReference type="OrthoDB" id="10253409at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895:SF9">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="888" mass="104677" checksum="47B9C4069EAF6EAB" modified="2023-09-13" version="1">MSLNLLKSQFFISVTGTKTIDKTDQKFWNNFMQEFNIPLPKVNIEEFFTTINETFPDFPSNNLISHNLIELFLKSIEFLKEASGDNFKKKIDSKNALVVVNIFFVTRVLLQVIIQDSFPSAKLSILKDDKTEKKKKKKLSKKEQLKLEKEAQKKSRNPKKKDVRIKIDDHIVKLDRSTHTVHSISHFISKIQNHFQCSSKQKDPLQSCVNSMIDFIIVNDQTTDYSIYAILLEIITLLLTLLSIYFFEENDSLSKNNPNKESLEESDTFPDDWVEDTGNDFKPLDSKNLLSHIPEEKAQKLMQNLLNYFLSQSPTPKAFDSTWNLNPKKSSFFSRSHSRRNTQKFIVEIGSLPTYSLLLLTSLFQIDKVAPEITSDLSEPEHKDLTQLEIQVKSQLTFQKQIQYEFEDDSEKEKTVNEQESENEFIARNSHLPSNIYLRKISQMISKNSEPNKEEMSRIEVDFQNLFHCLTSNEKVQEHAILFLYYLTYNNWDFLLFSAKNKNLTSFLMILLEELYQYKISEDPIQKEKAPFTYLILVFLLILSERYRFKELIFSTNLQTVSWFKERQLTNISLGQLTIIILLQITHFHLLKFFKDEIFSIGLAILNNLAPFFANISSQETNQLLEIIDFVSQKVKDYSNFKDTENEEPVRQIEEKAGNKKDPKKKKTEKKSKKQKSKSKKNESINEEEIKQFEQMLGQLDIQYPYQNDFVNIESVNPPPTLTERPKRLVRKDNRNMFIKYQHEKTADFLLYSDYLLKLFSLINTALTNQFASNSQLIYTLLKNRRIFSVFTTHPVLWKYVSNFHKLDKFFDIDSLEKKFSQIDDVFDYMQSLIPKFLFQEKGFFFIENKIFRFKQTNSKNNIISLLSWFFISKNSSLHWDFDSFHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTF2</accession>
    <name>A0A9Q0LTF2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTF2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="231" mass="27589" checksum="C66009C32901C341" modified="2023-09-13" version="1">MQFSDLIYKNLLIKNQLEKITFEPVVEAVQSSVNQLHKQQSKLEKLKETEKEIEKETQELKEQKSNHEMRKKNREEVQDQISFVIAQLVEMLESLQPYVEIDPSTERKVTQLQNQLNHKRNFFDSLKKTTDDLMNEKKNQEENFIKNHDDLDNAKKNMIYLISEKEKLEKLFQKKTQELKQLQTKVRIVDDEFFVLKQRQLDQLNSQILSQKKSAQNFHSSNSNSKNHQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTH0</accession>
    <name>A0A9Q0LTH0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTH0"/>
    <dbReference type="OMA" id="PPRMKDK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="652" mass="77237" checksum="F69AB78E0E0131D1" modified="2023-09-13" version="1">MFEEPESSVIPKKKDIFKVIPVDFSNLDKNTFSLNKKPPKVPKKIEKFDEVLARLERGIIYTKRRKKRSKDEDDFIDDSELHRDSDTRIRLCIFFPDENPTTKRLRKYVKKPKESKHKKHKKDEKDEKDEKDEKQSKDEKQSKDEKDEKDKKDEKDEKDEKDKKDEKDKKDEKQSKDEKDKKHSKHKKHKKHKKHSKDSKKSKSKKRKNADNNKKSNEIKKPKKSKHKSKHKSKESKDSKKSKSKDSKKSKSKDTNNPKSKSKSKSKSKDPKKSKSKSKSKSKSKTDQSKKTNQTKKTDQTKKTNQSKKTNQPKKTNQTKKTDQTKKTNQSKKTNQTKKTNQTKKPNQTKKTDQPKKTNQSKKTNQTKKTNQTKKTNQSKKTNQTKKTNQTKKTNQTKKTNQTKKTNQTKKTDQPKKTDQPKKTNQTKKTNQSKKTNQTKKTNQTMDNYVERPNIQKNQNQIQNEVLNKNQTQNENKMKIENPNPNPNPNQNEIQNQNQNQNQNQNQMEIEVPDQNQNQIQNQIQNQIQNQNQIQNQNQNQNQIQNQNQNQIQKKEIQIQINKTQIENQNQNLNQIQKIQIEKNEIEIQIQKKNQIQNLNQIQKLNQIQNQNQNLNQNQNQKLNQNQNQNQNQDQSLNQMLNQPTNENQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTK5</accession>
    <name>A0A9Q0LTK5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein mpp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTK5"/>
    <dbReference type="OMA" id="MHRFVEE"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="453"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="821" mass="97773" checksum="8A32DE4D69D01F5C" modified="2023-09-13" version="1">MNSIDKIYQNPDLLIGASKETINELISTTKTLFDEEKKVFPSINQNLKQLFVDGFEPQQIWEEIQMQNKPLLNFIEKKIEKFSQEKKKGSKRKKNEETEEIEESEDELNEDELNENDLNEDDLNEDDLNEDDLNEDQLNENDLNEDQLNENEYKSEDDLNEDELNENDLNENDLNEDDLNEDDLNEDKLNEDELNEDEYKSENDLNEDQLNENDLNEDEYKSEDELNENELNENEYKSENELNENEYKSENELNEDEYKSEDDLNEDEYKSEDDLNENELNEDELNEDELNENDLNKDELNENELKKDQLKKNDLNENQNDSQQFSENDFLNSDDFNEFIENDGFLQNNNPSEEQEDAILEEEQLQDYLYGNNLDSNEENEDSESEDDIFYNDFFDPPTKKNQSKNESQIKQQKLSKDDEDEDEDEDEDEDDNEDPVVGDLLNLFSSKTKLKNQKIFKEIKEKEQEKENLEKIITESNEINENKQKNNGEKIESKHEKKLKLIKQQIEELEKQALLEKEWVLTGEVTSSKRPKNSLLETMLDFEFATPPDPVITQEKTQELENIIKKRIREGSFDDVQRKSEPQQEYQMKLPEVNQEKSKEGLAEIYEKEFQEKVLDQKEKSKLEKKHEELTKLYDQLTLRLDSFTNFRYKQKFIKDDLEIRKDMPSIRIEEKIPTNISDSNLLAPQEIYENKNQKEFKDEKELTRKEKKSKHREIKRIKHKQNKQKQFQLSNFSGIKIQDKKHAQQILEENVKQGNLPSKVKFSFNQKNPQLKFSSQAFFSRLEDEKKIKQNPKKLNFKSIGPNFQNNSNQPKKTTFYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUD8</accession>
    <name>A0A9Q0LUD8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUD8"/>
    <dbReference type="OMA" id="ICSHIFA"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="641" mass="79443" checksum="48D7AF0D0A4E2A62" modified="2023-09-13" version="1">MNETKIKKSNDQNNTKKQQKSLNWNEMSLLYKIFMVLIGIIFSPLILIYYSPRILKFLIKKFLKLIRFILKDIIIATFKWIVNKSVELYKKFKNQIFAFFHFLFKKIVHFLYLFWKKIIFPFSKFLYEKILIRSLLFVKRILLNFWVYFYKYFVKKFLKILFKIPEFIDKILIGFFTFIYEKIITKCLDFFGKIFDFFVRIIAVYLYKKFLLKIFKTLFNYIKKIVVQFPKKIFSYMLILLEKIIAFIEKWIFIKIPKFIYNQIILKLRKMLKDSKKMLKYLIKFIIKLPSLIFFKLPKWLYIKVIKPTYQQSKRILTWIFVKHLSPLYFKVIKPIYEIVKKISLWIYAKILLPFLVKFIKPIFLFAKKIMIWIWIKFPEFYSKIFIPTIKFLFKTAKYIFIQLPKTIETYILLKLPEIWVFLKKWIFIYISKRIYNNILLPIFNFYKRFRKLIFIKIPNFFYLKLIKPIFNFFKKISKFIFITIPRFFYLNVIKRFSKFFKTIFIIIPKKIFYKIREPILKICQILYKWIFIYLPKKIYYGILLQMLHFWKKSKRYIFIELPKLFYFKVMKPIGIFLKKISKLIFIDIPKLFYFKVIKPLGIFLKKISKIIFIDYSKKIYFSTLKPLGIFLKKIFQNNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUS0</accession>
    <name>A0A9Q0LUS0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General vesicular transport factor p115</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_03846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUS0"/>
    <dbReference type="OMA" id="GQETFCN"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="4">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="327"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="732"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5080361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="877" mass="100694" checksum="9393C21497A4C8F1" modified="2023-09-13" version="1">MNLLGKLIAPLPDDEKYIEELINKIEKKKDLLHTTSELIKFSSKKQKLVSNSINHIVSLISDEEDQKIITNALEILNNLTQKKKDDVWKLNIEKLTKNESFLQELVSILKTSNYEIRYFAIKLLTNLLHFQRIRIQPIILSTGNGISNIIQLLTDKREAIRNESLLLVTEFIKDNLEIQKIVAFEEIFPILISIIQQEEKADDAVVIQDCFNAMTTLLSDNISNQNYFRETACVQKLVSLLNLTNEDYSSNIEIGARKVTIINTLKIIGILVSGSQVGPNLKANQDILGKKDNLMSIIYLAVVLQIALEIRVMAFHVLGDIIANHPENQKTFSEIKITEESTESQTAKTIIWHILIIILYSPDIEEKIAAVYAFQCYLSENANAQISISSSITITPDELDKESDLDSASIGKLLIDSLIHHSILDSSNKENINIIENNKENANDGDNNLDPLSSWFASVIFCQILKDNHDSKVIALKAPLSTRNDSIQYLLPKLVDSLIQESNKETPKKLIQIGIIKILCIWLFNCNEAIAKFLSLDLVNPSKKTDPQLMTVKEGEMLTFFVSMILSNSNIHIQALFSLLLGICLLFDFNNQNNYSVISEQEKSLLQSQFVRIDNIIRTRIGVDVFIQKINMLKKSPQFIEAELDKSTLEIDVGNVDKFPFYDNEFTIFYKTCLNQIKSQFQNSKKSKKDFQFHLAPSKNNHQLINEQISPNDQIQENIPSKIIDLESTEEFQKIKKEIEEKNSQIQNLKQNLIEKDIQIQNLTQQSQKETEFLQEKLKEQEKEFELAKNEISIAMNFKKKEKEEIEEEFLKVKNELEQFKKDHNELLILYSEMDQENQDLKAENNNLKEQTSSLEARVKSLQVQLSTFNEFNLKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV54</accession>
    <name>A0A9Q0LV54_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M0811_05545</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV54"/>
    <dbReference type="OMA" id="CMEHESS"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF218">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="930"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="970"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1000"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="816"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="677"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="764"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="790"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="793"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="794"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="794"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5077855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1108" mass="128157" checksum="8F0E703C46E93A4F" modified="2023-09-13" version="1">MKLKDENEIKDENELKDEIELENESEDKDGNEDKNEDEIEFMEIRIADRQFTAKKKYPPNFISTTKYKIWNFIFINLFEQFRRLANFYFLIVMLLSLGPWTPIDPFTSIAPLIFVLAVSAIKAALEDYKRHKADKEANKALFKIYDPISESLIDTQSKDIQVGDIIYLTDRQEIPADLIVLSTSEEDDVCYIETSNLDGETNTKIRSGLSSTSHLNSIENLKNSKGTIKCELPNDKIYRFEGQIILDSTGETNALTVSQVLLRGCSIRNTKWIFAVVVYAGIATKMFKNQRGKGYHFSKFERTLNTLVWRIFLIQFVLVIFCTFMTGFAYYKIKDAGYVNEEDALWKELLTSFATYFILLSYMIPISLYITVELVRLAQAWLMQWDQEMYSPNQRGKMTVKNSDINEELGQIQRIFSDKTGTLTENEMIFSKCSINGNIYDFSNYIKNENNKDHESIILENDEDVSKIKSEIDQNNLIYKLFFQVLALCHTVIPEKNPETEEITFQAQSPDEIALIQAAKIAGFELFERKKKTGITLKQKDGELQSYPVESILDFTSARKRMSIIVRNENNELILLTKGADNVIIERLASGQEKSIDQISNDLTQFARSGLRTLLIAYRYIEENQFQNWKIRYEQALSSLNNRQQNIDQVYRLQDGVPETIQYILESGISMWLLTGDKIETAKSVGISSKLISPDTKILTINCLEEKNSISRLEKKFNKYCKSSNQNHNLALVVTGHSLTHLLEHKKEQFIEFGEFCKSVICCRVTPKQKSQIVDLVHENSKMICLAIGDGANDVGMIQRANVGVGLFGKEGNQAALSSDFALTRFKHLQRLIFIHGRYSYLRLSGVVLYSFYKNFSFILVQFWFSFFNAWSGQSLYDDWVMTLFNVIFTSLPPLVYGFTEKDANESIIEKYPQLYHTFSIRNLFSWKKFVIRFINAIYQSLIVFFVVYGTEANNPTLRYDGLETGLAALGSYCSSYSILIVLLTYALETNYWNWITHFSLWLSIAVIFLFLLMLSNWLSVFAYEYGVLKMMLSSSSFYTLLIIVVILGLLPEYFVKYWRTNYHPYDWQILVERYKNKKLLDNGSFPKVKKVDSLNVKKNDEIEIDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVA3</accession>
    <name>A0A9Q0LVA3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVA3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="264"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="488"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="591" mass="68875" checksum="D80A8BC3E1274DAC" modified="2023-09-13" version="1">MNEILYFGENNLGFCFKNEPDGITKPIQLKFENENENENEKQIKQIASSYLSTIFLFKNGKAIEYLKENDSNQNPQKIQIENIQKVTSNFDNQSILTKEGKVFAKGKDINLKNPNQFINISSLIKDKKDRIIEDIFSGSNSIYLLTSNQNVYGIGSNQYGQLGFDSETLPKTEKPILMMKNVSKIFSGNSSSSVFLLNSNQELFGCGYNYYSQLGLGESRKEAKIQKLTKIQNIPKGKIIDIQCGNYHTIMLIENENQNENPKRKFYSCGYYQLNGLGQNENENTYEFTEIKSSLFENDDDIIDFSVGNVHTLILTSNSKLIVFGDNYYGELGTGNTKNQRIPIQIELPELRFNENISNYHISCGYWNNSFLYYSPSLSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNGIKITQQIIDEIKTGIDYFQLNETNPNLFDLLINKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVY3</accession>
    <name>A0A9Q0LVY3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipase containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVY3"/>
    <dbReference type="OMA" id="MWLTDAQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="172" mass="19246" checksum="BD59131BB5196BD8" modified="2023-09-13" version="1">MFDNNQIIGIGLVGFGFFFMFIGVFMFFDRPLLTMGNLLLIGGICMLLGLKKTYSVIFDKTKWKATTLFLFGIFIVIIGYPTIGIIIEFIGVYGVFGGYLPSILGFLSHIPFIGKFFNASMLSKKKKCFMITNELNNPIYFDLESVDSPTPTKTSILLGPLITSQQIINNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW70</accession>
    <name>A0A9Q0LW70_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat and socs box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW70"/>
    <dbReference type="OMA" id="KCFRKFV"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="27"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="541"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="608"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="641"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="674"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="707"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="740"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="774"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="808"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="842"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="875"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="909"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="982" mass="110875" checksum="55E5EC89154F064D" modified="2023-09-13" version="1">MDIWGIIQANKLDSNNANDFELISKGANPNSVDNLKRNSLQMAIMNKSSSEMIELLISKGASINQKDKKGKTSVHYAVIYLENESTIEIVEYLIAKGGDIRARTNKNETALHLACQKNSLKVIQFLIQKGIDINAKTTENETALHFACQKNSAEVIRFLMEKGIDINAKTTENKTSLHFACQNNSLEIIKYLIEQKLDLKAKTNQNKSLLHFACESNSLDVIQFLIENGFHANSRTKSDQTALHFACKKNSLDIITFLIEKGADINAKTKGNETGLHFACQKNSFEVIQYLVSQKIDIHTKTEAKMTALHFACRYKPLEVIKFLISKGLDINEKTDENQNLLHFACESNSLDVIQFLVSKEFDINDKTDENKTALHFACENNSSLQIIEYLVEKGGDITEKTKQNETVLHFACEHNSSIQVIQYLISKGNEINAQTEENMTPLHFACHNNSFEVIKYLVEKGANIQATTTYAETVLHFACQSNSLDVVKYLVEKGADPNAKADFYKRFSQTPLHVACKSNLFEVIEYLVEQGAEIFARTKFDETPLHIACQYNSLNVIQYLVEQDADYDAAKFLNQTVLHLACKNNSLDVVQYLIEKGANIDAKTRNDEETILHFACRSNSFEVIEYLIQKGLDINAKTKEDLTPLHIACRSNSFKVIKLLVEKGVSINSLTKQNQNALHIACQNNSFEVIRYLVEKGIDINARTTYGQTALHYACQNNSFEVIKYLVEKGLDMNAKTNGNESTLHFACQFNTSFELINLLIEKGADCTEKTNENQTAVYFACKNNPSLRVVKLLVEKGADINEKTTKNETVLHVACQFNSPFEVIKYLVEQGVDINAKTKFDQTALQLAIQYNSFEVVEYLIENGADINQKTSENQTVLHIACHYNLPPNVIKLLIEKGSNVNARTNRNETALHIACQKNSIEVIDYLIEKGVNINEKTNYDKTPLSISIAYRNQNAVRILLKNNANVFELKKTEITKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWM9</accession>
    <name>A0A9Q0LWM9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Drebrin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWM9"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="142" mass="16034" checksum="A3A6DBCCDD8FEF1F" modified="2023-09-13" version="1">MSFAIAQYDYEGKEDGELTLHTGDEIIVTTIDNDSGWWIGYLKNDPDATQGLFPGSYVEIKEQQTQPTVDQEKTTKKPQKSTKNSKNVESANSAQDNSDDNIPKKFALSQSGHLWNLLFKNKKIDSNSETTEQTRLRALQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWY6</accession>
    <name>A0A9Q0LWY6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-protein coupled receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_14208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000015">
        <property type="protein sequence ID" value="KAJ5080059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWY6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022340">
        <property type="entry name" value="GPCR_GCR1_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02000">
        <property type="entry name" value="GCR1PLANT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="5"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5080059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="328" mass="38426" checksum="C28F70A25679C0B3" modified="2023-09-13" version="1">MISGEETATSIGASLGMTGALLIIFIFFYFRKLKLFYRKLVFILSIYDLFQSISYLLPGNSNGVICKIQYFLIAIFSTTSQFWSATISFFSYLKVYKQLDDKKLNKIHKWFHLIMIIPIIVLIIIVSITRDYDKSKTYWCTSVTNTFIITVYSFLWVFIIICLIFYILTIIQIRKVVKIYSTNSISTTKINQMNQIWIQLRMSFIPLIQIIILIPGTIRRIRNIAKPSASDIESLDIIQSLLLTSQGFWDFWIFVVFDPEIRKKIKNCFCSKSRNLEEENFGDEMDYPSKKEKRLLVIEEVFQDENEMKNTPLITNEFDSGIESENML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXI4</accession>
    <name>A0A9Q0LXI4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000007">
        <property type="protein sequence ID" value="KAJ5080575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXI4"/>
    <dbReference type="OMA" id="TWNRRYY"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="281" mass="32147" checksum="D9065C45AA7CDFE7" modified="2023-09-13" version="1">MKYLLHIALQNKYSNEIIELLISKGSDINSKNNQDETPLHIALQNKYPNQIIELLISKGSDINSKNNQNETPLHIALQNKYSNQIIELLIYKGSNLNSKNNQDEIPLHIALKNKNPNQIIKLLISKGSDINSKNNQNEIPLHFVLKNKYPNQIIELLISKGSDINSKNNQNEIPLHFVLKNKYPKEIIELLISKGSDINLKIDGNEIPLHFALKNKYPNQIIELLISKGSDINSKNNQNEIPLHIALKNKYPNQIIELLISKGSDINSKIMKIKYLFTYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZF5</accession>
    <name>A0A9Q0LZF5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000004">
        <property type="protein sequence ID" value="KAJ5080670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZF5"/>
    <dbReference type="OrthoDB" id="1592419at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="424" mass="47804" checksum="0E0F6B237A787BC6" modified="2023-09-13" version="1">MDIIKAAQDNDLNAVRQCLLAGESPNKKGGNSPLYMVFFGFSTPNYEVIKLLIENGADVNSRVRESVIQIALKKNKITPQILQLLIDNGVKMNQTDKQTPLIMACANKYSSKIVEMILSQKDTKVNASDGWDALHYACQSPIDFTVIQLLVKAGANVNARTNLTPLHIYSFASQNSIEVLKFLFISGANPNYNAGTPFHFAIKNKLDPEKIQEFLRAGANSDILDKSSVLHCACDLGSSEIIIKMLLAGGANPNLVNKKTPLQICKDTGRDDLVQIFQDFAINPNDTKMKYFSAVKMYFEQQEKNKSFSDHSQQESEQESEKSKRDSLFDLLSMAKKAKLQENSNQTNEKPRLTGFFSQVKENLQKKEESKFNSFKSELDDFKSEINIKIQSLVEENERLRKDLTDLQKRMKRIEEANPSLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZR3</accession>
    <name>A0A9Q0LZR3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZR3"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="379"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="525" mass="61271" checksum="1FB47438318708D4" modified="2023-09-13" version="1">MYLPKEKILIQKIQNKFINISSLIEDTNDRIIQDIVSGAESVYLLTSNQNAYGIGSNLSGQLGFDSKTLYKTDKPILMMKNISKIFSGNCSSNHVFLLNSNQELFVCGYNEYGQLGLGESNKIVINKLTQIQNIPKGKIIDIQSGGFHSIMLIEEEDGKRKLYSCGDNKYNGLGKTQNIRKFTEIKSSLFENDYDNILQVSCGNEHTLILTTKGKLIGFGRNSYYQLGTGDRKYQPIPIQIELPKLRFNEDISNYHISCGFYNSFFYYSPFLSNLEEDLIKLFRRNESCDISFKTENGEIIKAHKLILKYRLNENQNEIEKLKEIISNKSIKESNQIFEMIYSNRIINPILYFEIKEIINLNEKIEETMKRIYLNENVKDFIIERNEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSDKSFQIFEYWIYSNQIKEEIKITQEIINEIKIRIDYFQLNQTNPNLLDLLIQQFNYQNTNPKITKIIIKSKSKPKLKSKSKSKSKSKSKSNEKENCFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4M1</accession>
    <name>A0A9Q0R4M1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase estd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4M1"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053145">
        <property type="entry name" value="AB_hydrolase_Est10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43265">
        <property type="entry name" value="ESTERASE ESTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43265:SF1">
        <property type="entry name" value="ESTERASE ESTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="491" mass="57497" checksum="9A1F7C8D02D714C4" modified="2023-09-13" version="1">MNYFKKLAVHILKNDLANNNLFRIWSRFDVNAKKQLAPEQFQMIWSSILNSHGKILEVEVIDAKELSQQIQNEKKTFYVVVSVLTLERGFLNSIISFSDQKEIIQFMFQENKDRIKYIIPKYADEKKIREIDIIVGENTEYPLTGSLTIPELEDETKSNIEEKEKEKQKENQNENQNENQIENQIENQIEKKQKFPVAIFVHGSGANDRDESIGPNKPFKDLAYGLAMHQIASIRYDKRTKIFVEQMKQIRDKLTCVEEVIEDVLQAIQLVLKYDFLDLERVYLIGHSFGGNLLPRIFKMFKNSQKFDENLAKIEIKGLIFLAANSRNLEDLYVEQMEYILGRNSTQEEAERNLKVIRNQVENAKKKDLTHNFPTKELPMGLSALYYLDLRSNNSLKIINEVANQVSLFFLQGGRDYQVTDKDVQIWKDTLKDNPKFSQILFKFYDNLNHEFGEGEGKSSPEEYILTFRNFSEKAIIDISDWINNQNEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4P9</accession>
    <name>A0A9Q0R4P9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_13154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM104 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4P9"/>
    <dbReference type="OMA" id="GHREGHP"/>
    <dbReference type="OrthoDB" id="294541at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="218"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5067194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="569" mass="65211" checksum="DAE0063E89D19519" modified="2023-09-13" version="1">MVVDTKVGKLYSNCSAFIFTFNLIVGIGSLTLPNGFREAGLLLSTLFIIFLALLSYICVTFMVEAQAIVNLVFNEQNFQNEEEQEQEKKEFEITPLLGKEIYSESDQILDGDNLNLSPKQEIKEILKSTSSEKEQEKMEDNDYLSNSEDDLKGESDQPEDTTLFLDKKSPILKSENINTEIQEEPKILKMSQTRKLDLKHENPPELEITKRVEMSTMSEMLLGKGGRIAFYIVIIVYLYGDLSIYAATIPVSLSKTIGGFGSISEDNSYYFYLLLFGVVVLPFCFFNFQKSKWLQIFTLTTRNIAFIIMIILSIIYIGENKPSPKGLPIFRLQGLPLLYGVSVYSFMSHHSIPGIISPVRKKNKIKLILGLDYFSIMLAYLFFCYVAVFAFGNVKEDDCKHYPSSPCKIQRLYTLNFESYGVPFIAKYVALFPVMICSNYPLISITLRNNLQAVFRIKPTSRFYRYQRVVFTIVGSFPPLLIAFFIRDVSLLVDFTGSYAGICIMFLFPTLFVLFGRKQIHKKYGKIHFTQQSPFQSKFWLYLIIGWSIFALVFNTVIQILQFCGKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4U1</accession>
    <name>A0A9Q0R4U1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Partner of sld5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4U1"/>
    <dbReference type="OMA" id="NEQRFAT"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="5">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="6">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="23014" checksum="24C04E417C37DDDD" modified="2023-09-13" version="1">MNTEIGVELLKELQRTTEQLPKYDQSLVQKVIEETNRKQEQLHEMVKQKKYEDTISKTKLHILNYMIERNEQILTSYHLERGKKLIEMRWDFGSVIPNQIRENITQNEESFHHEYCQILEDYMNSLDLDLTQDHQPPSNDLYIEVRVLKDYGQIFIDGGQSIVELKKNSRLFLRRVDAENLIREGVLEHIISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R509</accession>
    <name>A0A9Q0R509_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein/nucleic acid deglycase dj-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R509"/>
    <dbReference type="OMA" id="CSGDLWQ"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="186" mass="19834" checksum="EBE141CC349FB542" modified="2023-09-13" version="1">MVKALIILAEGFEEIEAITPIDLLRRAGIEVTIAGIGKKTIKGSRGISFGVDSLLEEVKEEEFDAIILPGGMPGTKNLAANQTVIELVKKYFKAGKCVAAICAAPGFVLADACKIVKGIKCCGYPGTDKLIEQNEGILVQDDVFQDGKVITARGPGFAIPFALKIINELVGKEEMEKVGKAILIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5H0</accession>
    <name>A0A9Q0R5H0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5H0"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="256"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="308"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="474"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="579" mass="67797" checksum="48188C795463B9B0" modified="2023-09-13" version="1">MNEIIFFGSNNNPKLFKNKPDKIKKPIKFKFENEKQIKQISSGYLATIFLFKNGKAIEYLKNSKQNPEKIQIEENIQKVTVGYQNEVILTKEGNVFAKGDDINPDNPKEFINISSLIEDKNDRIIQDIVSSNSTIYLLTSNQNAYIIGSNQFGQLSFDSETLEKTEKPILMMKNVSKIFSGNISLHVFLLNSNQELFTCGWNYYGQLGLGMKAIQKIDKLTKIQNIPKGKIIDIQSSMYFSVMLIEDQNENENLKRKLYSCGYWKNNGLGKKENTYEFTEIKLSLFENDNILDFSCGNVHTLILTYKGKLIVFGDNYFGELGIENTEQQFVPIQIKLPKLRFNENISNYHISCGYFKSFLYYSPSLSNLEEDLIKLFKRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLKEIISKKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITKEIIDEIETGIDYFQLNQTNPNLIDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5L2</accession>
    <name>A0A9Q0R5L2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxilin isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000119">
        <property type="protein sequence ID" value="KAJ5068172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5L2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="432" mass="50245" checksum="DE1FA332EFA65194" modified="2023-09-13" version="1">MTTKEFKDEDKSSENYEENQGITGEDQDFAKLKRNDLKTNKISLRFTPNLENYKGLDSLVFALSYNSWKLVTTDYQQEKEKEKKEKEKTNVKKVDSQNNNNNNNDELEIEKDDQDNKEKQKSSENDPEKQNKIQVEEVSVRAIIAQRYQFTTKHQERALQNARSKKTVFSTTLEKNEMKQEILIELSVDTVRLMVKKKVVEKVLLHEIIFQYVDVKPTVMHIIIQRKNNKSELTVSFADVSTRDTFIETVAILMKQFLRSIGAETKMQKEGHLLGGSYFQGDLKKQPKADEEVIRSIVGQKKAKFHVILKHNNANRPAFIRFTYDDISFGVENTTILKFPYNHCNINQNESNPLTFVLRVKNQRPVELMAKNTNQKDLILHTFNYFQEIGLKVSLSGGLTTGFGVYSNLNYGYETDFFDSFADTRLEKEFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5W8</accession>
    <name>A0A9Q0R5W8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5W8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="334"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="503"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="608" mass="70862" checksum="F8EB738FECF0D2C7" modified="2023-09-13" version="1">MNEILFFGLNQLPKIIKNEPEIITKPIQFKFENENENENENENENENENENEIKQISSSNFSTIFLFENGKAIEYLSENDSNQNPSKIQIENIQKVTVGRQNEAILTIEGNVFAKGENINPNNPKEFINISSLIEDTNDRIIQDIVSGRNSIYLLTSNQNAYGIGSNHFGQLGLDSETLRKTKKPILMMKNVFKIFSGNTSNHVFLLNSNQELFGCGYNQVSQLGLGESIEEETIDKLTKIQNIPKGKIIDIQCGYDHSIMLIENENQNQNQNPKRKLYSCGRHGYHGIDKRHQVYEKRIHEFTEIESPLFENDDNILEISCGNAHTLILTSNSKLIGFGSNEYGQLGTEDTKHQYSPIQIKLPKLRFNKDILNYHISCGINKSFLYYSSPSLSNLEEDLIKLFERKEFCDISFKTKNGEIISAHKLILKYRLNQNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINYNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIEITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6E6</accession>
    <name>A0A9Q0R6E6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rho gtpase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6E6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MyTH4" evidence="1">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="50801" checksum="7844831ED0804636" modified="2023-09-13" version="1">MKSILISPKDFGKLENKSKTNFKEFLQELFPFKIFEKGKIENINYKDFLHEYKLTLLLDENFYGIDNDPDLSILDHVLNDLSQTNWEDPKISLSKSLIFFPSELFFPILPISSNESLKYIDTVKLIRKFVRTPRKKFEAMKKVKTFEKEKNKNKAPVNLIKQILEIIQKEQKEKKEKKEQKEQKYWICDEIYLQLVQLTNLNPNVEEKKNAWILFSFFSNIFNPKDWIKSKIIDYCDDTLSTSDPFIDAHAHFARIHLQIEKSHSNLEKYINDEYSIQFCSIIPFEFFTKQKLSILSKRKNLFNNTNKTPKMLIHFFNIIEENLFEIDNQKIEELEKIEKTDFQTDKNLIIDPDNPKVALFFLVKWMQNLKFTELIQIPGNLSKIEKKDIIFFLSNKNHDLEKAFLEELFDLLNDGDIFKRIIGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R761</accession>
    <name>A0A9Q0R761_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rcc1-like g exchanging factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R761"/>
    <dbReference type="OrthoDB" id="5033648at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="140"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="330" mass="38573" checksum="DE12D294E356AFD1" modified="2023-09-13" version="1">MMKNVSKIFSGNSSYHVFLLNSNQELFGCGLNRYGQLGLGESRKDWKIQKLTKIQNIPKGKIIDIQCGNTHSIMLIENENQNTKRKLYSTGDYEFIGLGKNEENTYQFTEIKSSLFENDNNNILDFSVGRDHNLILTSNNKMIGFGSNNSGQLGTGNTEDQLIPIQIKLPKLTFTENISNYHIFCGDYKSFIYYSPPSFSNLEEDLIKLFERKEFCNISFKTKNGEIIEAHKLILKYRLNQNENQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIEEIINLNEKIEETMKRIYLNENENEKDFIIERNEKKYKFPKININNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R773</accession>
    <name>A0A9Q0R773_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_11943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3RF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R773"/>
    <dbReference type="OMA" id="QACWALR"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="83"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="363"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="600"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="643"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="686"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="729"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="772"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5069043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="96998" checksum="364129D99C226AF4" modified="2023-09-13" version="1">MDPSICPKCFQNYSQERKPMIICQEGHSICEDCVKKINSCPFCRSSFDDFKPILNRTLLQLVEVFKLQSKEQKVPFIPLSELEVEPKPFAIGGSAQIYKGKFKGKDVVIKRMMAMNDEKSNHEFENELKLAMKLEHHSIIKMYGKTEMDKMMGIVIEFANQGDLSSKIQSLTFEEQIDYSLEIIEGIRVLHSNSIIHRDLKPQNILIIDNHPKIADFGISKVREHTLKVTSVTISFGYSAPELFQKENIYDTSCDIFSLSMILYSIFSKKEPFENLNPVMITVKVIQGERPEFPNDFPKELAKVIDKGWSTNPKERSSLNEFTQCLERIKPQKPILPISPNNFTPSKPSNNRTNLSPPIAKFVKKTFGIAQYDFEASNPSELSFSFGDEVEILAQHQDGWGDAKLKGKAGLVPLNYLDIIEKTVKMTPPSTPKSRIPRNQIDKSNQFSKPKSPISNLRKRETNQNQFRNSNQNQNQKNKIKEIKPQLEMNVSEKGQQTLEDFINQISNLNEKSIEETIKYMKQCPNNQKIQENGCFILQKFANKNEDNRNKLRNLKGIKCVIKAMNNFQNNQDIQLKGCEALWDIAVRNDENKIEIRNLKGIEPIIKAMNNFPNNQNIQYYGCSALENIAVNNENQIEIRNLKGIEPIIKAMNNFPNNQDIQYKGCGALQNIGVNNENKIEIRNLKGIEPIIKSMNNFPNNQNIQYYGCGALQNIGVNNENKIEIRNLKGIEPIIKSMNNFPNNQNIQYYGCGALWSIAVNNENKIEIRNLKGIEPIIKSMNNFPNNQNIQYYGCGALWSIAVNNENQIEIRNLKGIESIKKAMNNFPNNQKIQEKGKWALGRLQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8D5</accession>
    <name>A0A9Q0R8D5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intein-containing kinesin family member 19a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_02169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8D5"/>
    <dbReference type="OMA" id="MNINQNM"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="391"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="884"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5069599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1115" mass="126954" checksum="7DF29F6DEFF098C0" modified="2023-09-13" version="1">MSSISVAIRIRPMIGDEKNTQKIVQPLSENILLFDPGEEDNQVQNSNPGHKRKAKDSRFAFDFVADEDITQREFYSKTARNLICGEKGIFNGFNCTVFAYGATGAGKSLINSEVVYTPNGPRKNSSLKIGDHVCTPNGKFSSISGIFPQGKIPVYRLVFHDKSFVECSADHIWAALLTPRNTALKSPLSILTDTFFLAQCLKNNHFNIAIPISKPAFFFQQKTSISSYAFGIIFSALLKLISQAQKFAELLSIPPKYLFTSLNSRLEFIQGFFTCIPFNISPGGSLIFKLPFIISAPLVSQLRSLFESLGSICFIFEKHNFSLFQVSFNYFEIARKKHPHKMLFHPVPEGKGLVRRLCNIVSVGRHKCQCIEITDSRHLFLTRHFVPTHNTYTMLGNRENEQPGIMYMAISDIFSLIDKQSADFSFSLSISYLEIYNETIRDLLGTSSEKSLHIRESDNGTEVTNITKIPIANASQVFDLLKQGNAKRKQSPTLANQVSSRSHAVLQVILLKKERTPGLQSQTVSAKLSLIDLAGSERSTQNSGMRLVEGANINKSLLALGNCINSLAKKSKKAHVPYRDSKLTRLLKDSLGGNCLTLMIANISPSDKNYEDTFNTLVFASRASKIQTKPSTNRRKIHAHISEYTRIIADLRREVGTLKRKLEKFSHTLKLDQPNTSSNQNPSHPETFLQKLSKFVQNSDQDGNPLMNDESNPTIMETISLSNDINACKFTLKSAIKRFKEIKQSKHNENMNINQNMNINQNKNINQNKNINQNKNINQNKNINQNMNINQNININQNMNINQNMNINQNNINNLSENLHKNGQFLFDHLASLTDEFTQLENQYLQTKIAIQSLKTQHLLLSFQKTSYENESINSELKNLHSKISQFHDQKIQLQKKVENAQLNCQNLIKLINNHDSLDKSQIDFLLSNFRLKDLEIENTRLRQNEQSLVDLIELQTNQLNQLRNLILSYTTNSPHSSPLIKNLSPFRNVLHSPNVISKNFSHINNNQIQIPKKKISKSQIENQNQIQNQNQNQNQNQIQNQNQNQNQNQNQNQIQIQNQIQNNKENKRKYLHNNNNNNKIIGALKAKINDPKNLMQIIKKDLVFNFPSKKNSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8X4</accession>
    <name>A0A9Q0R8X4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="2275"/>
            <end position="2400"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="2414"/>
            <end position="2706"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2914"/>
            <end position="2952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2145"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2245"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2317"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2801"/>
            <end position="2840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1805"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1900"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2151"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2320"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2804"/>
            <end position="2818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2827"/>
            <end position="2837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2952" mass="349318" checksum="B0EA14EE98B237F1" modified="2023-09-13" version="1">MKKIENQNQNENENQNENENQNEKNQSFLPEKMTCIFELQENCWFSQGFYNLNKKYNIIQYNLKNNLNISFEIHPKLKEIFRSLFKLFKLIISIENKQIHSSTEINKKPFSDQLMLIFENIFDDNYHKENEIISQTRKIIANENPMIQFICISLFKKLIEKNILSVQNQKKLLRLFSTKYFFYEMNDIYQTQKKIPQSFIDLKIELFQTIFLFIRKIDSSYDLVILFFIFLLSSKQSNLKIYSDIFQILIQIISFKKNQPIRDDLLTPISEILINLKTYYKKEIELLGNEAELTKNQFINLIYLTLEVYRLLVEYVNKDKFLDSAIPINALFEILPQRETTEFSLKILEGLFKNSQKFKSSRTKIIFNKINQYITNLEEKVNQGEDNAQDQIGEMLDFLTEAIHINNIKLKILISRNGIFKILKGLVENENLKGFLTQKILNFLFEIFSDNRKSIHIFKEQITFEEFGEVLYKSEGQNPRKEIYTLLFHMLFNEEVSGVGKNYVIQTPEIIILIFTVFARPHLTFFNNLIDAFSWLCEKSIHNRSCCSNSGLISILVKFIPQLQQQPQSQKKVLRLIKIIGSYRITVKELKLIFSLLKGDENNFRTSYAHLIINSLKQISSKETNAPRVFFDFHLLSSCLEIQKPLSWPSKNGYSFCTWIRFENFTDSLNRNKIFQPTLFHFSNETQNFSVYFETETEEEFQTRMKKNQSNNSDDNFLVEWKSEYFSPSDYSEDTEREELLSSNEIKIGDDIQNNEEKKNITIFRKQQQQQQQHSRTKSKETQRTIKLCISLCFGKKQKLNRLEKIEFQMNCREWHFLAFTQNYTRWSSSTDFNFYLDGVLVQQKQIKYPNFSNFNKNRIGSNYQEDSFFGQMGTLYFFKTTLSKTQVADIYQLGPNYISTFHPSEKKVSKNLSSLNSQLAMCYNSKATDSIDCFDQSLNNLHAKFLRMFKCVSSHLYDIIYCIGGIKAFFPLIIQLDQPLNQMEEKNLKKVKENEKKTDKILNIISQKRDPFRFSGQIFELIGDILIGSSLNQKDMIHSNGFAIISFLFQNINSEHITDNIISTIRRMYLGIRNKKFREDLVQNFILDYRLWIYCNISIQKKLFELIKYIAESFLPQNQNQNQNQNQNKNQNEYENENENENENENEFNLQYLLDIVHFYLWTNKHKSSKAIPNEKKELRKDKIIGKKPEQKEILELRNLYIELIKQIVSKKNDRKLVKVLLSNCFVSEDADFMVSMMEIIYFISETKKVSDYLTDDSDLFNALEPFITLLKFENQEFQEICLQIILKIHINEITKFNEFQKNNDLHGALQVMMISSEFENFLQFSPLLQEQNYQIFHENVIKIQLTRQVSEIMIKLLFLQPSLQRQMDEISSQKAHILKTIFALIGRNKNQESVNTMMEITNNLKKFEKSRKNFIAKQDWQEWIFSSYHFDDLHKQIINRKTKQSEKRYDPFGSKINYYTSDLLSFLIGEMFLQKKDAHLEILKFVGILEILKENKKIENAAIITRFLFERIISSLSTFIHKTRGKFVEEFDEFNRIRHRNNFQKVLQQPHFRYLMMNIGEFILIIGNFVFFPSSTKIANLTKKNNETFLNKSSNIDIKNSPKKKKVSKTTSFSRLKPAFSVNMIHDPFVVVTNKPLTKSLSTTNIFIGEENQTEKANSLGEITSLVIKSESNDVIWEDYGLVRQVIDFLDYYGFIQNGMNLNKSNKKDKNEDKDSQFLSRKKQLMIFETVLEFLLLSVEVSTVDECIEIFRILKSLEQESIHFLTKKRVIEHLLIILASLINFINSNLDKDLNENSNEKLDKDLDENLNEKLNEKLNEKLNENLDKDLDENLNENLNENLNENLDEKLNENLDEKLNENLDEKLNENLDEKLNEKLKTNSNEDLDEKLNEKLKTNSNEDLDKDLDEKLNENLNEKLNEKLNEKLNENLNEKLNEKLNENLNENLDEKLDKDLDKDLDTDLLILEQESFIEENNITKIQPSETEEEKNDKNQELMKKKEILIKLVHTFIQEHQILLAEILLDEKGEHFLAGTDPAKIFEETNKIFTSNGWDFALKQQMQPALEIFQKKFGKQKESYLDNLNKVYQSLKQKPQAIIVKNNEFEKYYQEVCRKEETRIYSIFIRHNSSFVNKLWGNVLHNLTSERGPWGKGPEENEEMHWKLDKSEDESRRRRKLKRNYHFNSHYEASVTRDQGLKKDAKILIEKYQMENISTEKLKNTLSGIYLIPEIDEKDEQDLDSKIYQQGSPIKQKKDDQQNNNLNDETTKESVNKATKKKKAEFQYNTKCTLVKPYNVIPGNATLTPEFIYFVPENENIENAKKNNSNSNSNSDSEEKKEKKEKKEKKEKNHKEQTWQLKDITTIYKRRYIYQRTALEFFMVDKTNYFINFENGDREYIYKTIVDLKPENLRIDFDTNDPIEWIQDSQYTTQWIRHQMTTFDYLMKLNTISGRSYNDLSQYPVFPWILSEYSKSSIDLNDPKNYRDLSKPIGALDEKRVSYFRQRYEEFKRACPNIPSFHYGTHYSSPGVALHYLIRMEPFTTLAIYLQGGKFDRADRLFDSIEKAWKNCRKSTSDVKELIPEFFYQPEFLRNSNKFDFGKKQSLEQIDDCKLPLWANNSPEEFIRINRKALESEYVSENIHQWIDLIFGYKQRGKEAEKACNVFYYVSYEHYIDLSRVTDQRELKSIKTQIENFGQTPLQLFTKEHPKRWSRQKVIQHYGDKFIYWRMRQISDLRRFTLTIAKSPILCIGLFASKDFDAFIGVTDQIIIYEKDRYLSTHSWVVKSFEEINRHIEVYEFQKGNENLEENNGNDSKNGNNNDNNLEKDSKNNKNNYNNNNNNLGKISKNQVIQDNFCPFSIHRDNASYQKSAIGVSVVPEISNLSNCVSINHNTLFTCGYWDESFKLTSIRKSKQMQNIIHHKDIVTCIKSKGKFLVTGSKDTTIVVWNFNQVKGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R941</accession>
    <name>A0A9Q0R941_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R941"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="473" mass="55130" checksum="ABCA9EDB00E0410A" modified="2023-09-13" version="1">MIPKPSAISLKIFEEMTKIPITINQQKDVLFQDLSLHSLESNSEFSFDLNYFEELPDELLLLIFSKIRKPCYLGICSCVNHQFYRVSNDWTIWKQVLKDYQDSLDFQTVQQNKYNSTISAYGQIGLRDYFANKSSINQDFNESDDSDQNLIDHTELKIKKMEEKFAKEINTNPKQIFVQKINELRKAIQMGNERKKRESIAKIYMNINDVLLHPLFLILSFFIFLVLTPLLAALKLENKIKKSWFLVLIPTFVSLVYSSVSGFCLKEESYLDFITEYYLGFGMLFSPPFILVFIVLVVLKFEYFDSILMVYSLIPLLFLVVFLAYPSLKNFYAKSDTQFKSSFYEDQLFFFGFPVSGIVLFIAMIFFSIGIDFKKSDNGLIIAGFAILMGFGLYGLIGMIFGIFSKKSNISKTFYVICIFEFLFACVFIASEVMLMLNLVFNFSISYFFVFIPFFIVFGFTTLFLLGFWWKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9E3</accession>
    <name>A0A9Q0R9E3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9E3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="332"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="501"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="614" mass="71851" checksum="3080AE85747CC8B5" modified="2023-09-13" version="1">MNDCLFFGSNLFHLLLKNESEIILKPVQFKFENKMKNQNEKQIKQIVSTFFSTIFLFENGKAIEFINYSSQDHHCEKIKIENIQKVTVGFSVEAILTKEGNVFAKGYDINPKKPKEFINISSLIEDTNDRIIQDIVSSAYAIYLLTSNQNVYGIGSNEYGQLGSFINETQKPILMMKNASKIFSGSYSDSIFILDSNQELFVCGFNQYGQLGIGRKTKTETEIETETETETDEDKEIFNLTKIQNIPKGKIIDIKTGNRHSIMLIENENENQNENPNENPKRKLYSCGYRQRNGLNKNTYEFTEIKSSLFENDNILEFSIGFNHTLILTSKGKLVSFGKNEHGQLGTRNKTDHFIPIQIKLPKLRFNEDISNYHVSCGEDNSFLYHTLPSFSNLEEDLIKLFRRKEFCNISFKTKNGEIIKAHKLILKYRLNENQNQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYCEIKEIINFNEKIEEAMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTDDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIINEIKIGIDYFQLNQTYPNLFDLLINKFNNQNSKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9F5</accession>
    <name>A0A9Q0R9F5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9F5"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="296"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="473" mass="54923" checksum="EF9DC5F3C1AD8F93" modified="2023-09-13" version="1">MQEIKELNQQIFIKQIFESRKIKQFCDFEITTESNDTHFSTHKAILNSRSIFFQKLFENNPELAEFEIGNYSTNTIEKILDFIYSGDVNLTRDSVLEIWKLSEKLGLKGLHDLAECYLRTSVSSQNVVSVLEETETSSVPDLFNLYCDFAAKNFDHLPDQERLCFVSFDVLLKIVQNPSFNPKSQFDLLMLFVKWSRKHNLLDPYANLLDKQPEFIKDSISAFLVYVDFSQMNQKELAQVCKLNVLSENLKTKFCEEKKVEQNLDSEKNDQITNENQIPSDEKTQSNARNPFSDSMIVEDEKHKELLKKWIESDEFYENMNLGFQATRDGFDCKEFHEICDDHGESLALIKTKEGYIFGGYTEIGWVNSGQVDIADPKAFIFSLVNPKNFEPQKFHVQKKKEGQAVCYKTGCGPSFGHGHDIAITRDLKSGWTYFGFVFELPKGIRYRSKEAKEFFAGSFDKWEVEEIEVYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9P6</accession>
    <name>A0A9Q0R9P6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 4e related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9P6"/>
    <dbReference type="OMA" id="CTKEKRI"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="220" mass="26247" checksum="82B2B75140D48131" modified="2023-09-13" version="1">MLSINRIEVQDSYSLKDEPDEDIDSTLHPLNGSWIFWALPKNRQQTIDWKDRIQKIAECSTVESFWSIYNKIRMPSEIQPGNSLFFFREGIKPEWEDEKNIGGGAWDFQFQIEHNHYKNYFQEELPHDKIWIDLLLGLIGEQFPETELICGIVVTIKPNFIRFSIWTQESENELAQTEIGDHIRKIIVLYQKISSLLYFSHEDRQNQISNRYPKYQIKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9T5</accession>
    <name>A0A9Q0R9T5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9T5"/>
    <dbReference type="OrthoDB" id="10595103at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="55895" checksum="9BB322923C352F5F" modified="2023-09-13" version="1">MDEDWGTISVAQNLFEFMRRDIISQKEKKKNEKKQKKEKPTENIQIEKDQDQDQDRDQDNQTNTQEIELENANSMMNLSTNAEPKTTLNFLANSKNLFSNKHLRNFFTSIFRWLKLFAVFHSCYLYFKQNKFWSIIKFLYRLLIILIIIFPIAVSIFALVVNIRKYIYDKDDVWIPGFWESSLNTTLSSVAAVALSLLPLTSWIFAYSFFRKPHFNELCNRFFKCPINGPRLARKVTAYIAFLIVYPILATLIAVTVNYVQSKMRDRIKKEPKIFIIDLIISLIYYWFQFAIVAFASILVLFLSQLHVLIIKAFNQIYTSGDWSISDLIDYHMDMQKDIDQTCSYLKNYIAVMTGLFGMALLLTIYSVFASPGLIGFRFVNICLYLILISFLLWFPAKVSGECEELSSTLMSTHISVGFNQERANELSLFFIYINNWTRSMGFVVYDVLITKSLVIKLIYTVLSIVLILVQNELVDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA46</accession>
    <name>A0A9Q0RA46_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bzip transcription factor 60-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA46"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="236"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="307" mass="37146" checksum="4848309E74A95C75" modified="2023-09-13" version="1">MNKPPDKNNLQTEIITTKNQLNEKIQYQMTKLKLQHFQLRQDEIKLNEKAEKSRVMEEKLKGKINFGDLEKQSIKSQENKTFMQNNIIAREPNHLQNKQIFYSNPKINYFPVKNNFQLNHFQKENQFNFNNVSDTENPFKKKIMDDSFNDLIQAKINKENQKNFNEKNQNPKNDYKLKIDDQRNKKRIKSIELEEEEEKMQSKNYENFNDENNKNNENDEHLEELTRKEVKNLTKEEKRKRRLLQNRINAKRSRNRKKKLVEDLENEINSLRAESKMLQLNLSRLKTNNERLKHQLSLAQNGFKFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAA2</accession>
    <name>A0A9Q0RAA2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_09123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAA2"/>
    <dbReference type="OMA" id="KPTCLME"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="186"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="789"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="946"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5072912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1068" mass="124716" checksum="24F80370AA6D93FE" modified="2023-09-13" version="1">MESEKNFARRDKLIQIEKQIQEEWREKKIYQVDAPNEKRTGDDKYFATFPYPYMNGKLHLGHAFTYSKAEFATRYQRMLGKKILFPLAFHCTGMPIMASAQKLREELEQQKNEKTNQEEPKKEEKKEEPKEVPQQEQTIRHVSAKSKAKSKSLSKQYDIMKELEIPDEEIPKFTDPLYWLKYFPPLAKQDIERMGAAVDWRRSFITTEANPYYDSFIRWQFETLKDLKKISFGKRFTIYSPKDGQPCLDHDRATGEGVLPQEYVLIKLKIQKLPEILSKLNEPDIYLVAATLRPETMYGQTNCWVLPKGEYEVMKAKNGEVYICHEHTSLNLSYQGYSEEQGKPNILAKISGRDLIGLPLSSPLTSYKTIYTLPLLTIKMNKGTGIVTSVPSDAPDDYRALQDLKENQKMRDEYHLSDEMVLPFEIIPIIEIPGFGTVAAKKVCDDMKIKNQFQADKLAKAKEMVYLNGFYNGKMIIGEYAGKPVQEVKNIIKEYMFSTNQALSYSEPENKVISRSGDECVVCYTDQWFIDYGEENWKNQTTQYLEKVNTYHPETRNAFIHTLGWLKQWACSRTFGLGTKIPWDTKWLIESLSDSTIYMAYYTFAHLLQGNLDGSEIGPLQIKPEQLTRKVWDYVLLDKEYPQDCGIEKEKLDLMKKEFNYWYPVDLRVSGKDLVQNHLTFWLYNHVAIFPEDKCPRSVRSNGHLLLNSEKMSKRTGNFITLSQAINKYSADAMRFALADSGDTTEDANFVEKTADSAILKLTRQLDWFEKMLAQIDQLRDGPIESYFDKVFQNQIHETLNSTKESYERMQFRDVIKIGFHELQSFRDSYRLNVGSDLNMHKALVKEFIESQIITLTPITPHFCEHCWKMLGKKDSIFDILWPTVEVDYSVVSGYEYIMKTIDNGKKSLKNYFNPKHKGKKQQQQKNTPISPPKKCILYLQKVRTPWQSKSLEFLRSIYDRSENQFKLDEKQISKTLRENPELKKDFTKVMPFVNYMKDEGIRTKGRLLNEKLPYDEKTMIETCMEILKSGLSLEEIIIKYVDEEKESQFLRIAQSSQVGQPSIRFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAG5</accession>
    <name>A0A9Q0RAG5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MITOCHONDRIAL 28S ribosomal protein S29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAG5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="728" mass="87048" checksum="3AFE88CDEFC2FAB2" modified="2023-09-13" version="1">MNSKKEKSENYLNRNQIEEELSKIRIEEHRKKKNCNKITGIPVNIFIDSPSEMGSLKYGNLTPILIRKQNQIFMKKIEEGITGIRVFHGVNGSGKSYSLYHLAAYFYQFNPFLQDPKINQKDQIPNQPNSNSNSFSKKQKWVVFYLNNLQNFLKKESHDVASEIMEYFFQNYGESLFQKCKFNFDKKFWFEDDPLQDEQKKVGLCKIFLQKLIKLKTNEFRILIALDNYNDLFRETNQNQNQKHILDFFKTVREIQSGLIIVATSPSFEYRNTIRDIDLITSGFKSYFYNQEEFEILSKWKQKENKLPQDQTIEKFEDLTNKSPRMLYIISQTYDDLNTFSGDTRKFLIQSQKNCISHYQKRIEFILEKIQELWDPNRMRQEIEFPTMVCLNENPDFIPDFWEVAELFEEILIEEENDEKKEKKTNSNQQIQPTSYFESNLKLVPITKYIREAFFEAFEKPQISLFRFLFQSGDELRAFELVVLNIFRRSLGSKIELNHMSLQGKQRNPFTFNIKIRNIIYQDKDNPLKKMEVGDFIVCFEGHSRIDFVCLSENEKKEKELFFIQVSTQIYNENFSKVDSLFQDRDFENQTNTSILQYYSELSGMNCSIPKWNEIESEQKKQKAKIKQLYQKQKENEEKHLTHKEIQKIRKSTLILPKNHYYFYFTHQDYLETTSQFAKDPVILVNKEEIFGLKSLDFYQFLFASSKIHKQETIWNNLNFQSNSKSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAH9</accession>
    <name>A0A9Q0RAH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fam11a b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAH9"/>
    <dbReference type="OMA" id="CATIQME"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="591" mass="69023" checksum="72160F117071DE8D" modified="2023-09-13" version="1">MAFSQSGDDFGNFISEDSDVVPANETNIVEYSQKKDEEQQQKQQPEFLDNESLENYIIYRGKGVIQITDDFFEKLFYDPRQGSGHLTSITFDESSLVVTVLPEEVWLIIFEYLSVRNVLSIGMVCKDFNDLTFDRELWRRLAVRHEKLFSWNKLGIKEDVQDPFVIGYQFNIDEKIEELEEKQAEEIKKAKKEEENLSLLRSTRTIRLEKRTISESRIQEMYQSTPNLLQNIEQPSDKRNIFNRVRPRRRKGESDSQTTRINENNETVPLALSTPRKRIEYINLLENPRESLIEKFQALIKQKKEVDEFVERYRKERMERIRNQKKKDDYFISFSLVVSLFHFSLIVFLILLNLRCDNVISLKYSIAYIPVFIMLAVAGILLFFLSRLVEHGYEKRSFLAASLLTELFNIQFLLFALKTDNTITVNWPTAMIPLYIIIGVGTILMCGYCVANLESIGLLYIFYLAGFMFDLFVIFLSLKLNGNTSMNWASVFSPLFVIYLLPCCTCCATIQMEEGWVYQIFSVVLFIFIIPIGVFQILLSIYLQGSSSISLMSYVLIPLYILNGFIVFFTFPSCLVALFQLFCYDNSYDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB75</accession>
    <name>A0A9Q0RB75_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB75"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="495"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="600" mass="70216" checksum="22CF065049B7EB55" modified="2023-09-13" version="1">MNDCLFFGLNKYPKFLKNKPDQIIKPIQFKFENENENENEKQIKQISTGNYSTIFLFKNGKAIEYLKKVENQNRNRNRTQNENPQKIQIENIEKVTVNSGNEAILTKEGNVFAKRRNINQRNPNEFINISSLIEDKNDRTVQDIVCSSDAIYLLTSNRNVYKFESNEFNRIRPKSIQKNPIKPILMMKNVSKIFSGNTSNHVFLLNSNQKLFGCGSNLFGQLGLGETLKDKAKIIKKLTKIQNIPKGKIIDIQCGRCNSIMLIENENQNPKRKLYSCGAYYCNGFDKNEDIKEFTEIKSSLFENDDDILDFSVGNQHTLILTSNSKLIGFGSNFYGQLGTGDISDQLTPIQIELPKLRFNEDISSYHISCGFFKSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDTSNKVKDYSELSNKSFQIFEYWIYSNQIKEGIQITKEIIDEIEIGIDYFQLNETNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBY3</accession>
    <name>A0A9Q0RBY3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molting protein mlt-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1916412at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="379"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="825"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="858"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="924"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1114"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1147"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1366" mass="156894" checksum="4667F74357467900" modified="2023-09-13" version="1">MSDKPKVYRVTFSEGRYKVVASSTDSTAKSIIDYIIQKTPDLNPQPNTYLCFSTQSFERVLNDDEKPLELGLTLSSQEPDEWKSFLHFKIARKDLLTVKIFRRNSSEPLAFIINENSNIQKLIELIASKFPVEDIKKTFIQEQFGNEKPQIIDNQKKIIDIIKGWGDKCENYKFLYKDSNLQIKGMEDFFYKYESQKIEDVSFDEINRNIMDIVVEGNSFYLKNEGFVDDTKGNSEFIHDNLSLLDRIKKEMDDEDSQFSKYLQRSKQMIDNKIDAYLEIAVPKVAKNIGIKGCHEITTLVNSFESMKEKISKEKVQEYARNVKDLDSLYSIRVAKIQGGIIDLIKQDLGVYFFNTKNELEMATVDLTKQTGTLSFLSNPIREGFLLKKSRTWGRKKLLYLVLTPRFLHYFHVPKNKEDSLEEILQSGKPHQSLPLSIIKVQRTVLEQQTTSKETSKEQKEVEEEKDISIDYTFDIIYDTNRYHFVAASEFEMNEWIRLINLIKSRVSEKKTIQVHRVNQNCKYEYSINYIGEQDAQSLDYKAEEGTYQIQIESFNDKWIFTKKFVDFIDLGETLRKLLPIFIFPTVPKNFRLGGVIRNRISTLVGKKAEEPPKKEQKSGKKGFFKSIFKDNKKPKVVLNETAIRLGNDFIYSFLNELLVNFRVNQLPEVLDFFGINNIFLAIKQNNLDFVKYLTINDTLYTLSRKQTGKTPIHFAAKLRLDLLKVIIENIDDMKKNKSLDIDFDLDICHVNSKDQDGTTILLQSVYDLRKDVFDCLIDREDIKVDIADNNGFTPFLASFKKNLLDFAKKLVEKNCDINCQDEETKNSALHYAFINGNIEGVNFLIHRGIDLDLQDKYGRTVLMLAVTSKRDDVINKLLESEANVNIQNNNFKTALHYCVEQNNINLTNEMLQKEGDPNIEDENKETCLHFAVMNRNLKMIELLLDHKASPNKQNINGMTPLHLAITQEIKKQVQIMELDSNQNDVQKQASSLEIIKLLIEKGSAIVDTQNAEGNYPIHSCVIRKDMDLLTYLLQNKANINAGDRDGRTPLHLAALSSNNRIIELLVSFNSVVDISDITDVGSSPIHLAAENNNIEGIMFLLRNGSSINCLRQDRKSPLHLAAKNGFNDLVSLLAENGADVNLQDFDGNTPLHLSLKSNHERTSALIAQSGGYLNMINNKGQSPLQLAKNSKIKKMIKEASERFASQGLTKRGTIPNIVTDIRTPESSIESHDKRKSFNPMGGLALEKLKSAKSAVDAHGLIPEYLKIVFHLNDKADDFKSRISTRINFESSEIENVKDILIFAKKKIKFDPENDDLDSFTILYEDESKEYIIIDFEAKLEEIFKFGKLIHIFHKEDFLKLFGLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBY6</accession>
    <name>A0A9Q0RBY6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Juxtaposed with another zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBY6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="379" mass="44498" checksum="6F391F02168EF166" modified="2023-09-13" version="1">MITRDDIFESLFEGFSDLSTLLNNNLREEIRSSLQEKREEFYFSSIQSPNQINPNQINPNKINPNQINKINQINPNQVNSNQINPNQINQINQINQRNKINQINSNQINPNQINPNQRNKINSNQINPNQRNKINKINQINPNKINSNQINSNQINSNQINSNQRNPNQINSNQRNQRNQINKINQINSNQINPNQINKINQKINQINQINQINQINPNQINQRTKRKYLNENESSESNENESSESNENESNENISSQTESNQSSQIHQQQIKKQKIKRRTPKIGYKIDEIASQHPEWFEGWDPNTYKNFKEKGIVPDRIFIKDEAIFLLANLDPSSKKKTAKWKNKRKVVTQILANEMEMVNTEHPFKRYGIVRVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD19</accession>
    <name>A0A9Q0RD19_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD19"/>
    <dbReference type="OrthoDB" id="449062at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040325949" evidence="3">
        <location>
            <begin position="35"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="214"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="354"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="400"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="514" mass="59290" checksum="5C4F3BF0920FFDD5" modified="2023-09-13" version="1">MIRSSTFLFLFLFKSKTKFHFFLILLILQKKTTNEQYNIQPIIQVMIMVPNNEDIHADGISVCLKYLKLVKDYVKKFDFSKIQVIMNSISTFPKNQDILNKGIEILDLVSQTNKNIKNLQIIPSLLHAVNFTSNEEISLKAFFLFEKIFYENFSQINEIRMSFLELNGVQSMITLMNRFPTNKDIQIESCKILEKISSNFDEAKNQIREFNGIEAILNLFNNFPQNEDIQDQAFWILRDLSFNNEKNKTRIKQLNGIELIIKCIYQFPQTGYLVYTACDVLYNLIFETDEFEKIPKKIVSSALLFEGLEQTIKKMNELQNNEDIQKYGCFILASVCFDSGLSVNQNVNQIIKLKGVETIIKAITNLPNHPEVQYYGLSALGNISLSENGRVSIRKSKGIEAIIKTMFNFPNDEPIQSKACWTISQITKDSSSVTKFKKEKGIEMILKTMENFPKSERIQLYGCVSLLEILMSRKSNQNDIKKLNGFEIISKAMQIFPQNGAIQEMGNQLLQNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDH9</accession>
    <name>A0A9Q0RDH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDH9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="395" mass="46603" checksum="E53F98C134C0DB29" modified="2023-09-13" version="1">MSEKQEQKHDVNKNENELKNENELKNENELKNELKNENELENKNELENKNENNPQSFKKLFNVSILKKKNNQKQQATLFLDSAKIELKTPNEIYTNKWTEKVKVKQHQTKDKLAKIKFQKQKKGIFRCFDINKITISFETTEQCNEFIEEFNEFGSLKIPMTSFSVKLLNKNLVEMNQIKVILGTNDLTLITEKRINVPILQTKISAHPRRQSLLKIVLENEDSYFILFPNPEKCQNFLRIFRNHYMTLKNHQEIKTKQESSRHDLLDKNMKTDSDSQSHKKISTYQIKILDSQLNPKINGKVDLGPATFSITTPQETLSDLFRKNVFIESYALDNLITKISFQKKPKSFWSCSSREKIILKFENDFNKTEFISKAKEIIQEFSKDQKNQKNQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFW9</accession>
    <name>A0A9Q0RFW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFW9"/>
    <dbReference type="OMA" id="NSVEWNS"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="356"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="546" mass="64947" checksum="AD783B8ADA2D0D9D" modified="2023-09-13" version="1">MKTYSNLEKLSNDLKNLFQNENQNENENQNENYFDFEIICEQNQQINPISFKTHKSILSSRSQYFKSLFNSKMKEYQENKMILNDFSIPTLNLILNYFYSGKIEINLENVIEILFFSSKYLIDELIEICSKIIKNNLQFETVVDILKLSEAMKFNQLLNSSYQFILENINEFIKTSFFLELEENQFKSIISSGYISLNEFEIFQLIIKWGKHKLNINQEKENEKLEKKEKEQIQNQISNIIIEQIQFNNFSEEEINKTLKDDLIPKQISEQLIQFQKLQNDQNNEAELEKLIQFQNQSQNQNQNQIQNQNQIQNQIQYQNQNQNQNQIQNLHQIQYQIQIQNSSNFKLKSSFNSSIIKTKENFNKLKEWINDDEFFSKMKKGFSAKKKGFNCKKWHDKCDNKGKTLIIIKTTENYIFGGFTSIGFTNDKSKWRWCDRKFSWGYIPDSKSFIFSLRNNKNNRNPHKFPIKKDQEKNAIYYHPNYGPIFGMGITGDLEFLDSLEYGKSNFGSSYKLPNEIEYDTNEAKSYLAGSFNSWKVDEVEIYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGW6</accession>
    <name>A0A9Q0RGW6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-secretase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGW6"/>
    <dbReference type="OrthoDB" id="19866at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="1">
        <location>
            <begin position="824"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1006" mass="118032" checksum="E4E4CC3ECD66E82B" modified="2023-09-13" version="1">MIRVNRLFSLSDNLEEVVPEIPKDSLDKIKQNKNKNKNKEEKAKKNIFPSQKIHQISGNIVKHLIVVGQENKHQKNSQTQILVSRDCYDKDLKMKTSIDLYNISFYIRKCIYQHSEKIYCVGASLNHNETLLAFTKFFTIREENEDISYYQTFIVELKNDNNLKEIGNKSQIFQKAIFLKNDFSSNHDSLLFIQDKFQIEVIKISLANKKKLHKKIISKISQSYLVCKNFLWYEFDSVARNLFYIKKRSGSEYILTCVSFNSKNSQILLEYPIKIDHLGQESNQNIYTHHIYTHGYTSPDSNLNFEIIQLSHSAFCLCQQIIMFPTHNVPFILVIIWVLHRQEKLEIEIPLSGISQEKLKDIRVFFGSVCELLLIYIPGKFIQFVDCAKIHETCDSLRFFGNENATPLGDSNNEDDNECIPNISKIVFLAHDSTETLKKQGNCLIDNKNETAFRYRIDTNGIYHIFTSPKMMKFSIPTLHILVMHMMEPFRVNHLIYHLSGNFPQALTPEFFQEYLIGNTYLNFRNYKFESNLREFANNLIQAFPVTSILSYQSIVKKLKKGIQTSHDLNIRKIQIQESTNSKIGFKPCKRFSYLKFRKIPYIALVNEFEDTPNKKKKEGDDLFDQFIEDKNYFWPGHQILNQRKMIARIISDHIMQYFPIRTRNQKIFVIKLINIFLNCMNDSVNSLFSVLKSVLLSVQIQGKNYEITNIKSWKNLQSLSMENEIKQPSRKIIKKVILEQRNEFAKKYIVKPIPKRNAKKNSSKNKTQVDKSNAENSLDDDFVNINEQNSFDSTFTTTTDDNQNQQEKSTKDLEHNFTLEKYQQNAFYVLRNLYIAIQELYYPFPENFHYHFCRLGILSQDRLQFLNSLKQDMFLLDEEFIDDVLKNLGDLDIDLKIQLLSSLENEENFLKKAKQEPQFLKNVVEIVSSRVADIFDFDSEKNIKYQRNEKQGGLPLNLWCEEISEENKSKFKNEIELIESNSSLFVSQNLNQNSNLNSNLNSNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH36</accession>
    <name>A0A9Q0RH36_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH36"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="319" mass="37261" checksum="04E7981D71156E60" modified="2023-09-13" version="1">MQSIDISVIQKHLFLGSEKSIQNIQKLKELEIKRVLSVEKYHEKLEEFKNHQDILHMIIEINDMETENLLSHIESALNFIENGLKKNENVLVHCQAGTSRSPAIVVGYFMKTYNLEFKDANEIVASVRPSVQINQGFISQLELFYKMGFNFNGNSIWHKEYRMKNYLNLHKEKESINTNQLENDEKQKSQEINEKSIEKTEIQIDPKEYVHFRCKLCRQILFTEDNLVEHETGYNAKNFNEKKKSETKMFCSSYFIEPMDWIKNTSQINGKISCLKCGTKIGSFNWSGSQCSCGVWVSPSFRIPKTKVDRIDPKNQLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHQ3</accession>
    <name>A0A9Q0RHQ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lim domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHQ3"/>
    <dbReference type="OMA" id="CYEQQYA"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="70"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="162"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5078989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="303" mass="34371" checksum="98D4A240393B1BC4" modified="2023-09-13" version="1">MSYEYLSSRFKKNDTDSTLSAMLGKTDPKPIAVETNVQYRCEGCNRIIDSGDVVEHQGKYYHRSCVNIDFYCTRCGGLCIGKVIHTSTQKTYHPQCFTCGHCGLKLNPDRNYIEKGGRLLCTKCASQIKEDKKVQIEKIQQKREQQIRDRDEFIKNQQKGKEICAACGKIITNDAVIALDVMFHRKCFVCKACGLPFSESQFQMVDGFPYHPNCHSKKFGKFCTGCGKEIVGKVIQAMGSDWHPSCFRCTKCHSTFSDGAYIEKNGKPYCPSCIPQEPKEIVVTTIRRRGFVVDPRTGKKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI95</accession>
    <name>A0A9Q0RI95_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000027">
        <property type="protein sequence ID" value="KAJ5079559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI95"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033579">
        <property type="entry name" value="TMEM128"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31134">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31134:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20479">
        <property type="entry name" value="TMEM128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="17110" checksum="37A79E7854631FCF" modified="2023-09-13" version="1">MIENNSQKPSDSVNIKTKIFEAILLWILTILVFTKGELWLTLTSEEENVSSFWFYMSLLCFIFFFGSFFYLVFYIPLFKKKKVDWSYEIISTKHGKILKISTASTVLFIPFFIFAIWPVYRLSSIPITILLWSTFLFTVSFIPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RIX7</accession>
    <name>A0A9Q0RIX7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_03718</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RIX7"/>
    <dbReference type="OMA" id="YRMYVKG"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="815"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="844"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="944"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5080234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="996" mass="110927" checksum="7628819DB41C4113" modified="2023-09-13" version="1">MDKEALQFTLTIPQLMGLHTIGDKNNLEKLQELGGVEKLTEELHSNLEVGLPQWEIKEGFTTRRGEYGSNRFAEPPHSSFFGLFFGTFKDTTLIILIVSAVISLVLGLTLGDRSSDWIDGTAILVAVLIVSFVTAINDFQKEKQFRRLNKVKEDIQVKVIREDPSNYGVGAEQTISFFDLNVGDIVILSTGDKVPADGILFLANELVANESGMTGEADDVHKSIDSKPQMLCGTQVIEGEGKMIVTSVGIHSQWGDAKKNFEKPPDPTPLQNKLDKMAVFIGKVGLYSAILTVLALVIAWVVWAIKHRSTFSRDRWELLVDYIIIGVTIVVVAVPEGLPLAVTISLAYSMKKMMKDMNLVRHLSSCETMGNATNICSDKTGTLTQNLMIATEVYLFGTHYQELPSADDLKPEFIELLNEGIAVNSKAFFEKVDGENKETGSRTEIALLKFVQRFDCDYQAIRKKFEKKRPKIFTFSSERKRAGTIVEKEAGYRLYLSGAGEIVLGRCSSSLDENGNVVEIDDSERQRLNSILDAMASNGLRTITLAYRDFDEAQGDWSNEEEIESNLTCYCIVGIKDPVRQEVPYAVDECQKAGIFVRMVTGDNILTAKHIATECGILKEDGVAIEGHEWRTKNEEEQLALLPKLQVLARSSPKDKLTLVSLLRKKGEIVGVTGDGTNDAPALKEADVGLAMGITGTDVAKEASDIIILDDNFKSIVNSVMWGRSVYDNIRKFLQFQLTVNVAALAVALIGAISQKGTPLKAIQLLWVNLIMDTMAALALGTEPPTRELLKRKPYSRDESLLSNIMKRNILGQSTYQLIVLFVILYAGGKIFDYNTSNDDEETHLYTILFNAFVWCQVFNEINCRKIADENNVFKRMFKNPMFLFIVSITIILQTLIVEFGGEFFSTKKLTWAEWLVCLVIGALSIPIGFLLRLIPVPVDKVKPKKTKDESDEKTSLLDNEVKINEDKDNDDDNDGDKEKLNSDTSDDLIDDSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4V1</accession>
    <name>A0A9Q0L4V1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4V1"/>
    <dbReference type="OrthoDB" id="10616420at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4185" evidence="2">
        <location>
            <begin position="340"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="637" mass="73956" checksum="EBA149E2021F308D" modified="2023-09-13" version="1">MNKKKKKKIKKIKKKKNKKKKKSFSKQLLLYIALLIHLSPIIYGISNKYSREITIKLVFESFSGWAYLTNILCLLLIFLNETIFKTKKKLKEKIQLSRFLDHLILTTRNIQISICVGYWVVVIPLTAKFTDSPFSIINKHIKKTWFMILNDFVLHVLPLSILFLPFKKCYLSMKKWITLIPFLFFFFVSYIVFSAAYFLTCRNPPYFIEYSVGVGWGLLILLLYFLGTILAHSIGYWIFRKRKAKKDPFDLFQDEKKLLIRDDQNKPKTKIVNYKAFAIICMILIILILISGIGVGLSLKDRETLSNYKITYEEVTPESNQFWSELTQAREKASITSQDGGTDVVIALDNSSAMWFYCDTILKNGFLSNTGMIITNSNNSYQINYYLSNTDHASEIFLRNSTEKGSELAIWPHGGILVNDTTYVYVDFVSRNDGQLWPKQKHVYGMYSAPAGSFNFTRILEASFSYPILPDFLFFNPQDNYYYAYFIQRPTIAMSGVYLARIHADKLTDPSQPYEFYYGDSKFSRDPKMSTQLSPPIAVGVFGQTSACWNNYLNRYVLFQVGVPGKFHSIYIRTAKNLWGPFSSPYLVYSQKSSSYLYYCPYVHPELFEEDGRVMYVTYSLSGDVNNRMVKIILEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5C5</accession>
    <name>A0A9Q0L5C5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5C5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="408" mass="49323" checksum="F64D9ADCA0296312" modified="2023-09-13" version="1">MKKFIFYLFFNSNSVKFQENVNIFQNIQFEDDVLKTIKKSTKPRSYNRINDQRKSQNVSRLKYVKNSIKKKQNQFFDDWRKKKIINQEDNQNQEDNKLNQENNQNKDNNNLKENQNPKIRKTKIRKIILKRNPKNQNIQSKSTNSQKIINFNQKTSKNPNIDRRKTTQFTKLSFHPDHLNIISKPKINYQQTKKKKTRIIKIQKRKTLLLKSQKSSLNSKQTNNEIQNQNQNQIENQNQNQNQNQNENENQIQNQNQNQNQNENQIENENQNQIQNENENENQIQNQNQNENQIENENENQIENQNQNENQNQNQNENQNENQNENQNENQNENENENENQIENENQIENQNENQNENQNQNENQNQNQIENQNQNQNQNQNQNQNQNENQNENQIENQNQNQNENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L605</accession>
    <name>A0A9Q0L605_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_03190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L605"/>
    <dbReference type="OMA" id="HCHENRI"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5066846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="306" mass="35089" checksum="043293B550608C3B" modified="2023-09-13" version="1">MTSLLRNLVKLQKVGEGTYGVVYKARNTQTNEIVALKKIRLEMDDEGIPSTAIREISILRQLKHENIVNLLDVVCTRDKLYLIFEFVDHDLKAHMDSVGKLDPLVIKSYMHQLLEGLLFCHSRAIIHRDLKPQNLLINSSGVLKLADFGLARSFSIPLRTYTHEILTLWYRAPEILLGSKHYSLPVDVWSAGVILAEMMMNYPLFPGDSEVDQIYKIFQAFGTPNESNWPGVSSLPDYSPVFPSFTPKTLRKIIKERLKDDPIDEVGLDLVEKMLVYDPKKRISIKQALQHPYFDDLKNLNEPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6I6</accession>
    <name>A0A9Q0L6I6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000131">
        <property type="protein sequence ID" value="KAJ5067267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6I6"/>
    <dbReference type="OMA" id="DYMNSQI"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="658" mass="77273" checksum="14BA982A854B85A3" modified="2023-09-13" version="1">MKKFKPQITIDGYPFSKNRHNSTNTTGWYRCRKRCGMTAKLFYNPNLQCTTNGQHKPTCQRISQSREVADLWNLVEELALDNIFTPDRVYREMCVRIDSDLEKAYITPSHQEVKNYVKNIRLPSGKKKKKKISRISNHQTLSKTDFLRVEQMSPFNIYIWASSSMIYNLSLAEQIFIDGTFKVAPKGFKQMIVVMAKLPKLNLFYPVLYGLTETKSYQNYLIFFAQLLGLIPDLNPDYITIDFELNLKKSLDRIFPNSKIIGCYFHYCQCLNRKFQELGLNEPIHKKLKRKLQKLPFVPQENILDKVKKLKKKFPNQERVFRYFRTTFMSDLRSQMWNYSELPKEIKRTNGCVERYNRRLNDIFPTSRTNLESFSAHLAQEEKYWQTRWSTTISRDGNFDFSSENSNSNSNSNSNSNSNSNSLFLNHPYLDPDFEIDEDFEFDEDFEFLSDSDSDSDSDYMNSQISKQQFAKENENQNQNENEKEKEKEKENQNQNENEKEKEKEKEKLTRKTRSKTISNQKQKQKQKQNEKQNEKQNEKQNEKQKQKQKQNEKENENEKEKEKEKEKKKKETNVESKLKSRSDSNSDSDSKPKPKLKSNSNSESDSKSNSDSNSDSDSDSESNSNSNSDSDSDSDSNSDSDFKSRSNSNSETDSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6Z0</accession>
    <name>A0A9Q0L6Z0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12843</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="169"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="907"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="454"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="630"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="716"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="822"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5067491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1339" mass="159113" checksum="C34BD73D4E98C01F" modified="2023-09-13" version="1">MIPTLQGLLDMGFESETAKIALDKYRDWDSIISFLTTGSPVDNRSLEKIEIFNFSLFIKFEERGITPDHHRSNGAPSAKRPKTNSQIDADNNKQRRTNDSRDERNRRNPHKRSVSFESRHDHPNEMDISLNDTNLNRAIEESYRDMKKTDYHYEPVFSKSDLREENTPVGLKNIGNTCYLNSLLQAYFHIPSFRNGILSFNPTQKDWVEMRSKLDIDASYANFFTPLNLIHELQRLFSRMLLTNHRAVDPSDAVNKILADDGTSFRIGNQQDVTEFNHLFWKRLEEGFFRIEDYKIKKEEDKKKLKRIEEIREERRKKKEKEEKEKEEKQNQLENQLENQSENQLENQSENKLENQMENQMENKSENQLENQMENQLENKLENQNQNQMENQLENQMENQLENQMENKLENKLENQSENQMEDQMEIEKDKNSKKPTNAFESYLKNFQKNFPKIMEEKKKQEELKKEQERLAQLEEIEIQKQYEQEIAEQKKQEKTEPKKQKDRDSLLSDVFHGKLNQTINGNEKDGTEINLKMQMDFAQIIVDVNHENLYSGLDEYTNKTTIDYKTPLGEDIKAIKQTTIQKFPPVLILQLQRAVFDSENKKAIKNNAKFTFENTIYIDRYLSRNIDIAEKKRKEAQFMRENIKKLKQEKKSIEEYEETKIPIFIHLENVKNYFEQILAEIEKKQNKETKESQLEMDINDDIPLDGQKINYRKTIDLLSDEIDLNKKRVVDIENEVEKNENQIREIYSEIDKTPYHLFAILVHRGVAGSGHYWAFIYNYISKNWWKYNDQVVTQVDEKVVMNDSFGDGTNAANAYCLIYINSDLVQELENEEEIEKKKEENEVVEENSNDSNKEIEIENNTNTAIKIANNAENKFKNIFIPQELIYEIQSENEELFKKVVEYEENQKKKREEEEEKQKQMEQERQYNHLTHEQRMKIHDASKEPKDDEKIRLVVEKHSEKLSEVTQKFDELDNNKDKESYLLATSFELFCMTKKGIDSAIFSIARDVFQEIFGKDYDLEVEHESKNINAKEIFDKLSLAADNGSGMRSYYRQWKTYLTNVSFYLEGLSQMLLSNFEKAFSFLAECFSSLLLLDSGDQNTPIFLQICSFIIFENARKRIEEYKFKKNEENLMKIENINENQNINENINENTNENSNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIENDLNSAWNITNYSFDIFDQKRFDSIDNIEDENLDELVLIKIRDDFLNFVQKKGEEFGLMNYDYSKLDFIGKMIRNFIEIFQTGVSKKDFIQLKCELSEEKVPELISQYEKITNNSKSQFIQISQRMEDLKFRIKQDFITQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L747</accession>
    <name>A0A9Q0L747_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EIF6</name>
        <name evidence="6" type="ORF">M0811_13399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L747"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="246" mass="26934" checksum="2FC4CD9A5F5CEB37" modified="2023-09-13" version="1">MAFRAQFQHSSDIGVFARLTNSYCLVGLGGTENFYSVFESELSDHIPVIHATIAGTKIIGRMSTGNKNGLLLPSTTTDQELQLIRNSLPDSIAVKRIEERLTAFGNCISCNDYVALIHPELDKETEEIIADTLQVEVFRQTISGEALVGTYCVFTNQGGMVHPKTHIEEQDELSSLLQVPLVSGTVNKGSDVISAGLVVNDWIAFCGLDTTSTEISTIENIFKLDDSKHPSKLVDNLRDSIVDQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L813</accession>
    <name>A0A9Q0L813_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L813"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="191" mass="22987" checksum="07D32A794032C9D3" modified="2023-09-13" version="1">MNYSLLKTPIHSFKKTQKQQNNNNNSNNSNRRSAFKSIQNSNKKRNSIYEPPVRIISSKKSDRKKSIQRSKTPTFKNKEKDKEKDKENRTYSFYFSKSKENYEKNENLLNEENRKKMMWNVITYLEKPQNRNQKTQFFNKTPAERKKPTCSQQFGSILREKNKTPKTEQRSLSHSYFTKTPNKIERILFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9U3</accession>
    <name>A0A9Q0L9U3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_12725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5068025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9U3"/>
    <dbReference type="OMA" id="IDLHYVC"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="232" mass="26559" checksum="931BA69900720DDF" modified="2023-09-13" version="1">MSEKRWIPLESNPQVFNRFCKGLGLPTEKWSFSELFGVDPDLLSFAPTPVLAVLLLYPMSKNIKEFGKKQKIEIETKGQEVSKNLWYVKQNIGNACGTIGLIHAIMNNMQTINAQGFLKEFYDKTKDLNPEERAKLLEESDEIQDQHDKSSKEGDTTPPDPNERVEYHFISFVNVDDSIYEMDGRKAFPINHGKTSRLSFLQDAADVIKKKFMDLDPQEIHFTLNILAPSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9W1</accession>
    <name>A0A9Q0L9W1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_12229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9W1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="475"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="596"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="641"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5068808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="912" mass="107664" checksum="2338E0056F1DB9D8" modified="2023-09-13" version="1">MNHNKDSVHKVETNGKYIRYSKILYKTDQITIYYALDQEEGIEVAWKQVKRDKLTRKKAKKLIKRANSMKSIQHKRIVHLFDCWYDEQKKVLVFITEFMQSGTLRKYIKRAKTLDFRVIQKWTQQILEALAFLHQLPSPVVFMHLTTNHIFVNGADGSVKIGDLGLSAMHPQDYIATPEFMSPELYDNKCSEKIDIYALGMCVLEMIQTKPPYYECENRAQILKKILFKLPPPSLSRLKNTLAANFIKRCISLIEQRPTAKELADDPFLTQVLQQQPKQSSSQNSSQNSQESDTNETTSENNQENNQENQIENQNQIENQIENQIENQNQNQNQNQNQNQNQNQNQNQNQNQNQIENQNQNQNQNQIENQIENKIENQIENQNQIEKNILQNDHKNSLSKALSEVSLIDSINNVSQKVSLKLKVFVNDSPYEVEFEFDIQNDSPDLVAKEMIEELQIPNYDPKEISTNIQKMVNSIKKQQQPKQQKESELKKELSQDEQLQKKQSNHTKEKLRTLEQQKKYEQRKERERKENEKRQKKENEKKQRFLKEQERKNQLLKSDLVLQYSEPNDLIDTILGQKSSKFDPLKDLIQNYELEHESDVSSEPDGEQDVEQDLTDDSESNSDDGETESYRMNSENRYFYEKQKQKQNEKQNENQIENQNQNQNQNQNQNQNQNQNQKKYQPQEYSHSNFIGANFNPNENLNPNKNNIPNIDLNGITTESHFYDSNKFFPRRTVSEEFKNFSGKSLNTQEFIKFLLAKKNTPNLSSFYDQNPLNIQDEQKFLESQDPKNGNDKKLLPNSLKQEQKIKSIQKSVDSVLQDLEKNQKDEFITLDNFFQEEERRMKFLHEQIKNELSKKHSIESRDLKEFLRNFQLQQQQQQQKSSPKNDKMVDLQLKALDGFDSKEMDQFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9Z1</accession>
    <name>A0A9Q0L9Z1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_02442</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9Z1"/>
    <dbReference type="OMA" id="KMAIHEQ"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000592">
        <property type="entry name" value="CAMK family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="12">
        <location>
            <begin position="652"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="402"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5068509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="702" mass="82017" checksum="EB8EC931247D9E1A" modified="2023-09-13" version="1">MSIQNKQIEIGNYVVGKTIGAGSFSKVKRATHKITQQYVAIKIIDKIKINLDPKATERLKRELQSLQTIQHPNVIELYEVLADTNYIFIVTEYASGGELFDLIATHGKVKEELVRKLFRQLIAAVDFCHRIGIAHRDIKPENLLLDNNLDLKIIDFGFATFINPNLLAKTSCGSPSYSSPEVILGKDYDPKKSDIWSIGVVLYCLLCGFLPFTGSDPRQICKRIINSDFTMPDHVSPQAQNLIRNILKKNPNERFTMQEIIDHEWTNMEFPNKIVRQISPDPKQFVFDQEILSKMEKLNFDPKIVQKSIQKRKCNQITTTYFLFKMQKQKFLEEKRKTEKIQQKTQKRGFFSKFRNKGKKNKKQPKEMKNKEKMKNNKNQQINSPSNDQELQMLIHINENPKFTADTTKSKISNVSNTNRNNKHNNYYDNNNNSNNNNNNNNNKKENLLPITPLHLTNLPDDKIKPIILSPKRRKRGNPTKLDQFFQHNHIEKEQEQEQEQENYRPRSATVTTPKKLSEKFVSVQPPIDKHIIENDERKPRSVTISNEIEGAQKVREIDEKEKEKEKEKEKEKENQNQNQNQNQNQNQNQNQNQKDQEMDICLNDQQETREIRGTFDATTISFKSPKRILSSCGKVFRKLGFIYVQKSNFDLMCTSGNVQFAVEIVRIIGIKRCYAVKFKRVRGDFWVFKQIWENIQPKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB76</accession>
    <name>A0A9Q0LB76_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB76"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF3">
        <property type="entry name" value="SPLICING FACTOR, ARGININE_SERINE-RICH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="645" mass="75206" checksum="33A18EF107239DB1" modified="2023-09-13" version="1">MKLKIQNQIQNQIQNQIQIQNQIQNQIQIQIQIQIQNQIQIKIENEIQIENSKIKFKNQNQNQIPNSNSNSNSKSNSNSNSKSNSKSNSKSNSKSNSNSKSNSNSNSKSNSNSKSNSNSKSKSKSKSNSNSKSNSNSKSNSKSTENENENENSNEIGNENENSNEIGNTFSEFLYNHTRNFEINSNSKSTENSNENENENENSNENENENSNEMKMKMKMKMKMKIQMKLEILLVNFFIIILEILKLIQIQIQIYIQIQIQIQIQIQIQIQIQLLFVFPIQQMIMLLNRDRYIDRDRYININRNINRNRYRSIDIDRYRGSNQNNQSLENENEAKILSQFSQSLNLLEENIVNMERNQINENDQIQKTLTQSLETNNLNHQINRFGEIISRIAGNFNFFRTLFSDLSIFISNSINERNDTNSTLRLHNLQLNKFTSSEKSLNFLGLIFNIISHQFQQIVPNLYGNTEQEEPLRIRESIVEINGEERENPELYFLLDNLVSLTRQVMENSSNLGNSSFTLSSLRNENETRTQNSDQLENLLAQLLLQSLLNSSESTEQTEEPRNSGNNMENFLRQLSEQSNSEQSNENILNQKRNVKQKQDKQKQKYKMRRKNSNTNTEKNVNQFLNIKEYFIKGHMNRHGKLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB93</accession>
    <name>A0A9Q0LB93_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-10-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB93"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5068408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="353" mass="41250" checksum="38AC312CD34355B4" modified="2023-09-13" version="1">MEINSFSNLNLNQEKFKTIIIDNGSYLTKAGFSRENKPKIIFETIIGKIRSRNVWIGINFKNSYIGEEAKKMKEILWIENPIQNGIITNWDNIEKIWNHTFYNQLKIVPQEYPVLLTEPPLNPKLNREKTIQIMFETFNIPAFYLANQSVLSLYQSGIKSGIVVEIGDGFSSVVPIYEMFTLNHSIIKQNLAGKDLTEYLENILNEKGNHLFTSGENDLINDIKEKLCYVAYDFDEEIEFSKQSISSIQKNYELSQKKIIQISNERFKCCEVLFNPYLIKREEKGIHQMIYDSIMKCNDEMKKYLYQNIILSGGSTMISGIEYRIQKEIYKLFDFDFDIDIKIISSPERKYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBM1</accession>
    <name>A0A9Q0LBM1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBM1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="115" mass="13613" checksum="FAF28E80F33E4C83" modified="2023-09-13" version="1">MFIKDIACGKKPDVFLSQNGIFFCGNWGTKIFWGYFFISLFSKRRKLLISSFKKWIRSTVMLAEVCLFEHTKILCRANHGYQDDKQFNNFLVKERMVKFIHVENQNLMGSILTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBW9</accession>
    <name>A0A9Q0LBW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clustered mitochondria protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBW9"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="3">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="891" mass="104229" checksum="41EBE6E1D798E0AA" modified="2023-09-13" version="1">MEQLKQNETNIEKYNEIMDLIGNFLQTATYCAQTIIDEYPLKKSDKTFKPLFKSKENHQLKKQFHQQEHFEDDQFQEIQYESSGLTFKFYHKYKPELENEELSMKMANHLIQNGKFIQEANILGIQIPLQCIVDYKGFRMHISAKLPQDKESVKLKDIQNLQLKQKIDLLLRKYGIAMNDEIMESIQVIELSGNENYLLNVEKFFPNEKSKSKSIEIKNLKENVVNRIRPELLVDIIKNNTNQNENDDISQIASDYLFSNTLPNFILQTDDLKIIPLDSEELKKEMHKNGINMRHLGVLANLTKIPHVRQLLMIDMIARICKKILFQQLRKTSKRIKNIESKEFPNLEVTEFDKKIMDSKEETETISNQKQIVFQTPNKSIKKNLFSEFNTPQNQKTINRINDNVSTVVIDFFNLVLGSSEECEMYWNSVLIPSLYFYQCNITLALNFLIVMNMISQKNYQLKNKILLQFTQSQKIFYNENIFDGKIPSNLNEHNQMIQNLNFKLSVQKSIYDYSNSILCANAALGASRKFHGFISLTYLILMKAKYQVGDTKSAIECFKYSLDAIRFHLTEYHPLLIDAYNEIAHLYQRENNIQYALKFYTKALELSKKVIGIAHSKTAWCFFYVGGCYIKTNNFQDALSNLESGLAVIDSLFGKQNFSASIFHFIISEILVSKGDLLKAKEHNEKVIEIQKNAFNLVQELKLENEIVNKNQIQNQVQHEIEREFEDIFKGSEKEYGKSEIKVILVKSIVQMGYIYEKMGENLKSNDFYEEALSFLKEMEEEDDEILEQIQFITRAILNLIFRTLPIEKQVILDKIKLEEIQGKSQTLKFPITKELFEDIVVEIFGQDQIKKYVYDLIEDFIQNGNKEALKKLRCVYLISKGEDLSMFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCF3</accession>
    <name>A0A9Q0LCF3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sesquipedalian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCF3"/>
    <dbReference type="OrthoDB" id="10566041at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="57"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="228" mass="27251" checksum="8829FA82D3E1E8E2" modified="2023-09-13" version="1">MTDNFDFFDFDGQQDQQKEKPIEETKETKEKKETKEKKNNKEIQVDEKVDEKDDENREIESSWLMKRSGAFHKTWQVRQFILTHKDLKYYKVQFHIESKNPLSNFVTFDPQLASRYKNATVTEKKSLKGTINIDEITKIEQVEKIGKSKFTFAITSQEHKKKKTKERTWYIDAKDQVEFDKWCLAFQIVGKNVEKLKHSNVKDESKKKDKKKKSSSKKKDKKKDKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCF7</accession>
    <name>A0A9Q0LCF7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="139"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="432"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="660"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="724"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1309" mass="151898" checksum="1DD10617F1EAE8A5" modified="2023-09-13" version="1">MKNKLNKFHQVYFSTIFLFENGKAIEYLSKNDSNQNLVKIQIEENIQKVTVGARNEAILTIEGNVFAKGKDINPENPKEFINISSLIEDTNDRIIEDIVSGYNSIYLLTSNQNAYGIGSNQYCQLGNTSDSIFLLDSNQELFVCGWNEHGQLGLGESRKEETKIKKLTKIQNIPKGKIIDIQSGFNHSIMLIENENENENPKRKLYSCGDYRYNGLGKSENKRRFTEIKSSLFENENDNILEISVGHSHTLILTSNSKLIGFGDNFFGQLGIGDTSENQMIPIQIKLPKLRFNEDIFNYHVLSGYKKSFLYYSPFLSPFSNLEEDLIKLFRRKEFCDISFKTKNEEIISVHKLILKYRLNQNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDDLFSTIFLFENGKAIEYLNRNDSNQNLEKIQIENIQKVTVGARNEAILTIEGNVFAKGKDINSENPKEFINISSLIEDTNDRIIEDIVSGYNSIYLLTSNQNAYGIGSNEYGQLGFDSETFKKTEKPILMMKNVSKIFSGNISDSIFLLNSNQELFGCGWNEYGQLGLGKSRKEEIKIHKLTKIQNIPKGKIIDIQCGVAYSIMLIENENENENPKRKLYSCGYYKYNGLGKSEDTYEFTEIKSSLFENDDNILDISVGHSHTLILTSNSKLFGFGNNYYSQLGTEDTKNQSIPIQIKLPKLRFNEDISNYHVSCAFYGSFLYYSPHSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEAHKLILKYRLNENQNQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTDDTSNKVTDYSELTEKEPLRFRSDGTFQIMQLTDLHYGDFSIKDIESDLAQEAYFKTEGSNTDFVIFTGDLLLPYVLDPKIAWENAIYFANSKKHKYCITFGNHDDSGRLTRDELIAIDMEHEYSYSQKGPENIHGVSNYYLEVLGSDSNETKLILYFFDTGDFNCEGVLGWSCVYPDQIEWYKNISNYLKEKNGETKPALAFFHIPFPEYMYVWNNNTCYGVKGELSCCSAKNTGLYQTFLEQGDVYGVFVGHDHKNDYIGNYNGIYLAYGRKSGFGCSEPERPIVQGTRIIQVQENSRLFQTYIRNKEGIKEIQEIHYPNGTSQTFCDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCH4</accession>
    <name>A0A9Q0LCH4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11008</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCH4"/>
    <dbReference type="OrthoDB" id="7956040at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="310"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="499" mass="58312" checksum="6C86D3D2D19807E7" modified="2023-09-13" version="1">MFYQDLKELSTNLSQLFTLENKQPVFSDFLVVTRNKTFECHRAILHARSAYFRGLLRSQMKETTEGKVEIRDISSEVMKNILTYIYTGSLEITRDNAIEILISSQKLLLDQRVLDNISQFVVRHVSLQNVAEVLSLSSRFSFETIHDYCIRFCILNFRELIHESSFLFLSASDLELILAADDLLIDSEQQLLESIIHWAKNRRDFNGQNEDLYQDEKNSPKNLIQKRLARLLPRIRFCEIEQTQLQVLQKQGILTNELFDDIVEFQCLRTQKVNAEEIENFLRKCKSRYSKSNFLAFQPRNCFPDSLVVSIKNTKLVNFLKNSIEDDVFFSQMRLGYSARQHGFFPLAFHEKVDNKGKTLVLMKTVENYIFGGYTEVGWVTDKQKWSTVNANWGWIGDPKAFVFVLKPSVNGEDHTPQKFDIKKGEEKWAILYRDTAGPQFGYDIRITSWDVNSVFDMIYSNLGNNYQLEGSDNPFKQKRKIPDSLEAWKIKEIEVYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCX1</accession>
    <name>A0A9Q0LCX1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrroline-5-carboxylate reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10836</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCX1"/>
    <dbReference type="OMA" id="CASRETR"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="5">
        <location>
            <begin position="106"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="216" mass="23260" checksum="3CC9FEEC1A8AB13C" modified="2023-09-13" version="1">MSRLKGKKIGFIGSGNMAEALARGVINAKLIKAEDVMGSDISKTIGWIQEQIKVPARIVRVMPNTPALIGEGAAGLVACKDAKEGDCETILELMQSVGVAKIFEKEEDLDAVTGLSGSGPAYVFRMMEAMIEGAKQSGLEEEKALNLTIQTVIGAGILAQKRLKDNIKPDKLREMVTSHKGTTEAGLNFMKEHNFFDVVRDAVKTATARSKELAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDK5</accession>
    <name>A0A9Q0LDK5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDK5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21979" checksum="C2647CB6D87D6F33" modified="2023-09-13" version="1">MSLRKTGSWLTFTYAILSFIFWLIKHIISLVDIEKRESALILITNQEVELLETNKGNENQNENENENENENENENENQNQNQNQKKNKNQNQNKKKIKLPPQTANFCIQQKSSAYLTFSFICLFYFIIIFGATFQIHQALIGSFLGILICILFLIYVIYKERGRIFNIIWISISIIFGIVILIAIVHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LET1</accession>
    <name>A0A9Q0LET1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sorting nexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_10448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LET1"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="125"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5071386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="57352" checksum="E14E1C048EBFF7C3" modified="2023-09-13" version="1">MKIIQVKTETQYDYEGKEDGELTLHTGDEIIVTTIDNDSGWWIGYLKNDPDATQGLFPGSYVEIKEQQTQPTVDQEKTTKKPQKSTKNSKNVESANSAQDNSDDNIPKKFALSQSGHLWVDTSPELVIDVRVTGTVEKGRFKKHTYYKIEAVNLKYTVTRKWKDCLWLQNQFFKLFPPICIPTLLDLKVANRPNSETTEQTRLRALQTFFNRLAAHPVLAKVDFFLEFLQHNDEKKWERRKKVIEKKTQEFWRLVNHQYPEPDAKEDKSIESFRTHLSIHAAKIRNLTGQLSDLCSLKTDSISTTLTKFSNAWKDFGEQGFDWREEVPPNAKDASSKIESIIKSIAETWNTIGANYKEQSDFELGNSLRHFNEYSQIITNFQPALKTRDDARLNYHVTQNALIKAERNALQNEKEKLKIEQARKQTERAKEGADTTSIILLAESEHFRTSRLEDSKIMLAEYLDSQIDFYQKIVDMFKKIRPEIDNVSIQKGNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF49</accession>
    <name>A0A9Q0LF49_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nudix hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF49"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="48"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="225" mass="26391" checksum="8241F9782659854D" modified="2023-09-13" version="1">MISKTESYFQNKKLIHLAQKPEQFYLLLKKVFKMEKYEKLEKAKKEEKKIASVVLMNFEKANKIHLLILKRTGKVRHPNQFCFPGGSYKKSDENLKNTVLRELYEETGLYNNFELIGNFTPSLSTSNFLVLPFVGYLHSNDKNKEENANKYHIFDKNEIEYASEISLEVLLKTESKSRQVFGTEKLWSGTTFGIKYDDLHLRKNIIWGLSANFLDSYFSILRSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFI1</accession>
    <name>A0A9Q0LFI1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein ltv1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFI1"/>
    <dbReference type="OMA" id="ICERDEV"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="500" mass="59605" checksum="8639DE70BFE21713" modified="2023-09-13" version="1">MTSQKTIITKTKKKHDRGIRFQLVHREQRDPTRYEDETSELVLKPINARIVNSPNTKNNEEDVITIKDSKTKQTQKLPKELFGDNNLLPIDTLQQPGINRNLDLDIDPDIALALESGSDNEYQEIEDNFVELAQGVEDKDKENENENEIYNDDKEYPDSFDDSFDGSFDSQFKSHHSKKFDTASNFSHISNRSQYLNFLEEKFEVVLRKEFGYESSDDEMNMEYDDKIQESIKENQPKLKSFKQIDSILDEFIEETKNKDQILENKQKRNKKDEKDEKDEKDEIHEINEKDEINEKDEINKKDKMNEIHEMNEKHEMNKKDKMNEINQKHEMNEKNEINEIKEKDEINEKDKKVESDEEINIMNEQFYLTHKEKLEFDCESIISTQSNFENQPTKISIPKKKVKKITKQEKNPVQLSKKTGIPLGVLPKKKEQEEKKKNTNLGKAREKETLKEKKERKKKIKEERRKRRKEKKETKELYRQEELQIKKNFYNSEKSVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHQ6</accession>
    <name>A0A9Q0LHQ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related protein rabd2a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHQ6"/>
    <dbReference type="OMA" id="RENRICF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="204" mass="23043" checksum="73B72B69C6D6D50F" modified="2023-09-13" version="1">MTTYNEYDHLFKILLIGDSGVGKSCMLLRFSDNTFMDSYISTIGVDFKIRMIELDGKKIKMQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTNQESFDNLQMWIQEIQKYGEKNVAKLIVGNKADLVDKKVISTEKAKSVADSFGIPWLETSAKNSTGIEQAFLKLAETIKETQDISKPKQTKPSISVVGTGKPKKKSKCVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHV3</accession>
    <name>A0A9Q0LHV3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sh3 and f-bar domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09898</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHV3"/>
    <dbReference type="OMA" id="AMAHVFK"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="331"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="401"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="113"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5071738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="458" mass="51960" checksum="117051E57FD03B6B" modified="2023-09-13" version="1">MSFGVDLWDQYEVVKKQVHTSFHELREISEFLQKVSKLQDNFGKSLFKLTQSIRPSDIEGTTQNAWGALITTLEGCANSNIDYAQHIFSEISSPILSFKDESSPTRKELFSTCDKKTRELKMLKSKFETATQKSSKADSDVDGFKGSNDSKSQAKLDKLKKAAAKATDEKNTAQSNYESFKKSYYSEIIPKTLSELQKLEEERMNLLKKQFEKFVEYSKTKYISSLDQLIQRFDTTVCGVNVNKDIESFIDKNKTLNRNPVVQPKQVQEKPKIEFEDTNESQVQETQTQSPPPVITQDPLPQQTNPMISPANQVLEEDENDEDSSESEGEECDFLVKAFYDYAGAEESDLVFSQNDIIRVVRKHSTGWWEGIVDGKQGLFPSNFVEPLDEQQKTSDVEQINIGDKCRALYDYSKEADGELDLKEGDIITIKGNEGGWFLGVNEKGIEGTFPGNYVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIM7</accession>
    <name>A0A9Q0LIM7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Wd40 repeat family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIM7"/>
    <dbReference type="OMA" id="HPFVPYW"/>
    <dbReference type="OrthoDB" id="10255181at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040323">
        <property type="entry name" value="EIPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="6">
        <location>
            <begin position="157"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="871" mass="99917" checksum="4D798FB3F343D3BD" modified="2023-09-13" version="1">MQNKLTGRLWRKNIDLESNEFSSDIKIRNYTNKQRFSQLTSFAIHSQSDYLLKSSFNSTKNESSIIEIFNKNRITDEMEIVYRFALNQPVYDMNWMDSRLLVASKGTAHLFELSKEFLDKISIIEKQGYNREELCGDLEEKGCYKHKHLGGRLLSAPPGEKNSKFLTIENNNLHIWDLNNSQDPLNTAQVSASCLYVSEYNPLMENIVIVGGVGSSIKIIDSRNISSHYSMIQNIENSKHDIVNDIQWSPFLPFVFASAGEDFTVKVWDMRFIQKAKPVYILEGHENIVDSICWSHFYPDFLFSSSLDHNVNFWSLNSSPNCLLSSQKIRNETIAGIACSRNSSEFVYLASKLNTVFSIQISEDFLSSLARNVLLKIKDRDMRTIHNCIFYRDFRQASNLVLSQSKNSIKQNHPKKALEITKLLRPLVLADFKQTPLRSVFWMCAVSIPPLFPFDWTQSVDSNFLFEKKLISLEAKLQLMIQQENFTGISKYLPKVQDFLLKLDFSTVSNMVEILSKTDIILAISLVISYGEQANDTEHSNFLNLAYPLIFPTVYDDPNEVFYSSIDNLKSEEKSIIQDHSKISNSKSDFSQTNQNPKKIRSTNSNTQDSNSQIQNTEDDNVVVIDESLRNLRQKKRSKKNLSFSLARPVVTFERILSQLKIMKNVHTFLGNNYSPPTINDHDTALSLFQDPLNLISITMLRLYLFLLLQKFQIIPFYIIASSFADEFSQAPIALLLQEMMSTIGFSILQKVLKKSYSQKISKRIIDIRNSLECAIEIATKSALIPKPVATFFQQVIPQFSSDLRNSLKDPKLVSDPSFANIQSQMKISLEKIHQFDFESRSRICKLEIEVAKEVLKSFLSKFDSTNSNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJA7</accession>
    <name>A0A9Q0LJA7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJA7"/>
    <dbReference type="OMA" id="HLAFICF"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="132" mass="15091" checksum="F4EC1F983257B439" modified="2023-09-13" version="1">MQIFVKTLTGKTITLEVDPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLNDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVDPSDTIENVKAKIQDKEGIPPDQQRLDFCRKTIRRWKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJK6</accession>
    <name>A0A9Q0LJK6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5073005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJK6"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="796"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="890" mass="103995" checksum="B5C1DFFFDE3D0C67" modified="2023-09-13" version="1">MGNQQTEVIKEKKEKENEKENEKENEKEKEKEKVENEIQVENEPKVFSYYSFMSNRGNGLHEACRNSDFKEIKKLVQKGSDINAKREYDEETPLLITCQKENANAIIKYLISKGADVNAKTQYFFENSLHLICRYQTTNTIELVKLIISKGVNINAKKVRNETALHVACQFQDFNVIKYLVEKGANINVQNEGKETPLHVACQFQEFSVISYLIEKGANVKVKTKDQIHTPLHLVCLFQREKAFSAIKLLIEKGASVKSKTKRNETALHFACQFPIGFESIKYLIEKGADVNVKTNFEQTPLHLACRYRQKNLFVIVKYLVERGADINVKTSEHHTALLIACQKNSFKTIKYLIEKGADINDKTKYENETALHIVCKSENLSRKIIEYLIEKGIDIHAKAKIRDETALHFVCQSHQPFEIIKLLVEKGLDTNAKTKYEETPLHMVCKMNYKVKVVKYLVEKGADIHAKNVIDETILHYICQNKSQHKFEIIKFLIESGADVNAKTNENQTPLHYICQNPNDNDFEIIKFLIESGADVNAKTNENQTPLHFICESKKDPFEIVRYFIEKDVDVNPQNSNKKTPLSISIEQKNHNTIKLLMMNDANIFDLKAKEITNEILDSFPKIYSLNEDLNKFLKSNENFFDLQIESNDSFKFQVHKLILLSRLNNDQLILQKFINICKNKPKEVVQFALNFLYSGFTDYDDLILQFEKLKELKKENDLMDERQKQSFDWDVIKKYEKTWKNFQNSVKDKLKKENEMISTLFEEIGIEREWIQTKSGRRGILKDFEKLYEQNETKDFTIIVKEEIKVHKLILIIRSDLYKGMFLSVEDSSNQVHDYSKKSNDTIKQFVYFLYHDTFRKDPISQQILEEFEDLKDYYQLNQNSIIDLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJR8</accession>
    <name>A0A9Q0LJR8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJR8"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="177" mass="20241" checksum="F78810F63406C43A" modified="2023-09-13" version="1">MKYSREPTEKSVKAMGKDLRVHFKNTRETAAALRKRSLPNAQKYLNDVLEKKQCVPFRKFKGGIGRCAQAKQFKTSQGRWPAKSAKFLLVLLKNAESNAKAKGLDVDKLYVSHVQVSRATPGRRRTFRAHGRITSFNSSPCHIQLICTEKGTPVARARDSRFERILRKKEKKKIENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKD7</accession>
    <name>A0A9Q0LKD7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5073013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKD7"/>
    <dbReference type="OrthoDB" id="10692996at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1047" mass="121290" checksum="1FB5B16F530D60D2" modified="2023-09-13" version="1">MSIKFQKQFCAIEKPIQHTFLIVCEVENENIEVICIFSSKEFSKFLEENEKELEEKIQKIFLTEKTKTNKKQKEGFLYLREENWRSVFATKKLKELKKAEFIEKIERNIPKNFKNETNAPNLIDFLGEEVSPNEMFFNLMLKEVVLEDEFKFSVDVSEVTGKEIIGSVPGVLFLKSGDLYLSIKDENWAHFYWDIEIFDMDEKEQGVLYHIEWNNQTKWKVFFQNQILAGVANSITTIRQKQSENFKTELSSPEIPNHKIEFDKMDLGDFIDIKDSNMENMLNTYTEEFPEEIEIAPEWKRLVQNYFIRQHADFDVECQSKITNGNAILELNAHTFCISIVGVYTATWRYGGKDRARMQISRKNPRELQLDAERGMVFGLTTKKPSESYVMMKTFEMFMGFHGRFPEAHRIKGDILGIKEEVVAIAYRSWALGSAVFHCTTVPSVTENILVTLRMDKTYLAVLSKDHPPLYFVWNEGCISYKKHPQNEKFFTISINTVSVNKALFLLAGDRVHRDLICTTLDIFSKSRLSTSFTTLISSPHTSRSQTSFKTVDLQDNPRQQKSKLALSLDNVSSLASARILVDPVLHRWDTFGEHFTSPLLKENFAIMPPAKKPRPQQLQTTYNYVPYYEQDRYEDAHHPVASFRAQITSTLDKNLGTVIVLLFEDHFAVAAEDDKIIRFFSPFARVFIDKNNSRKCRLVLDEIWYVVLVFETEKKVKKFASLLHSFKESYIFADLDVAQRPQATRASCNFLTFNESVAGEVVLHYDHFEINTTLDSFTEMYRIDHQISRHPTISLALELSLRPGATLTMCFPYASHAQLFKQVFMDNRFRLLSQTVGKKPPAEFPVVLQNLPDRTDVIKSRIVVSQSRLSLWHDTNILEVYRCADCVIFDNYGLEIKIQLPSFAAYLATFNNKNAKSSFVSRAKSSGIGLYFKPDASHFRIVKVDSKKSEEQGTLSFDEKMITLIILGKPFSNRIIETELFVHPANPRLLQVLFIGKESFVIFFKNNDSKLRMIQNFSATKLKLMKQFEKKVGFEEFAIEDPDFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKQ9</accession>
    <name>A0A9Q0LKQ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKQ9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040244677" evidence="2">
        <location>
            <begin position="20"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="731" mass="81604" checksum="D5EDDA6345DF69C6" modified="2023-09-13" version="1">MKIFLTLILILIIIKQNKTSFIRKASIDLEAGENNIIFSISDHQNKFGYFITEFSPSQIIKIRLSNFSKEGVLFLPKDITEICSGVIDSNDNFAYFGTQISPGKIIKINLLNFTYVQTLELDQQEYSLNTVFIDQLNQFLYFGLYLSPAKIIKIDLSSFQKVSVLDLPTEIAKISTSVYDPLNSLAYFATDTFPSKLIQINLTVFNYSQIITLDSDENNVACSVFDSQNGFIYLGTKKSQKIIKIKTDNFSKVDSLEISSNNSDFITSLIDIPNSLAYFAFDSDGDSDTDNPFLYQIDLQNFTIKNSVQLSLDQLPLSTGLIDTTNRFAYFSSYSAPTKIIQIDIDSLSQNSEKTLNIGENYLVSSVIDIVNKFVYFGTNTSPGQIIQIDLTTFQRENKITLSDGDNYLTTAVFDNENRFAYFGTNTSPGKIIKFNIDQFKKEDEIQLGNGEDLLVSSVIDIDNKFAYFGTNTSPGQIVKIDLINFQRANKITLNSGEDSLTTASIDIVNKFVYFGTNTSPGQIIQIELGTFIATRRSQFQDDNFFSSSVIDSVNGFGYFGVNDSTSKIIQVELMNLEKTGQISLSSGERFIDTGLIDSSHGYAYFAAMSMTWNEVIYRIDLANISIDSTISLDQGEVYVSSASFDDKNLNIYFGTNTEPGIVIQVEVSDVNPSPTPIPISVDISSQKYNAGIIIGVCVSMGFIVIIALIWVFRRSKNFPPKGAIPLDRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL52</accession>
    <name>A0A9Q0LL52_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose repressible protein mak10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL52"/>
    <dbReference type="OMA" id="YSAHEYG"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="353"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="758" mass="88649" checksum="BD200780C4E72BE5" modified="2023-09-13" version="1">MTNEISNIDLFTEKIEWEEIFTVLNEAKEEMKMGELLSSKEFTISKTKYYREIGNVKSDSGLVRVPGELFTIEEAQGSFPLSNLTAPQVLSVMDKLFCCEMTWLNGENIAQTIFSSFYCYYIESVQNKPLKLFCQSVLKHCVVILRLISTTGVYVEDEDFTTNVFGFNLFDGPINQNLEKFEKEIIQESELRIESENEIANELDTLLDCMLGGITKNDFLEALLVRFKLRKLLLNIQETFEKEPNEDNLEILHKKITEEMEEIILKLTKTHEKLIEIFGEKDPPGFDTEIHRRRISPPTQIRTVKIFDFGSSISMLKKIMDETKWICEIFGYLDPMSKINWDSEAIPEIGYRERLFYYLINFSHKNPNIISRSRLKLLVTQEQSILQEIKMDEMIIEDMVEFGVLPKYAKHKEAHPTIMTISFVFTEMISAPCFEKTTYYKKLKKLFQLWGSTISKGNQLDPTLVSKSDSQAEDFGLHDTHIIKNFPFSCWMLDVSLNICIYYISLCFELDLYSLPESTSAFWYLHYLMGIKLKTMLAGNLYKITRNQKFPIQFEISSKKTKGRKAISQHKLYKEQERQKNQRIQEERDLATTRFMYLLQAQQLICRALLHLMLGCEKDNIIGPSQNQKYSFLNMQAVFKNRFNLIHFVLNPSHSYQTFTEKTEFLRENDFPSFCESALNSLDECQATIQECFEKRRKESMVSLIDDELESIKKLAFANKIAVKLILQLREKQKIPFLSFRFDIHPWLPVVCVSTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL63</accession>
    <name>A0A9Q0LL63_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of g-protein signaling 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL63"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="251"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="380" mass="45890" checksum="FFC158FA8B0A67B5" modified="2023-09-13" version="1">MNQDLVFSSSILNQKRNRISQHFSHLRQQHQFQQQYQPKFQKLHQHQRSLTARELKPKETNQNNVKIIVFENDLDDDDDKSENQNPKENPKENSKENQNKIKNEEFPSPKKITQNSPQKNDQLIRSKIFPIRKSLSQVSTVEQNQPFFNQEKKLKEKAKKSKKKNKNKNKNKNKKRKSVQNQNQNQNQNQNQNQMKQKKKINIENENKISSKFTRIIQKRKQKKLQKQKKSQKKELNEEEYSRLKEKYFSNFSEFLFVKNSTIYFRSFLQTEYSEENIDFWQEVENFRKIEIGQSKIGMNEYALKIFQQFVKTGSPKEINIDFKERAKISERVRNQNFDLQMFDSAQESICRLMENDCFVRFQISDFGKRFLNENFDLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLB6</accession>
    <name>A0A9Q0LLB6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLB6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="395" mass="46878" checksum="E034AD84E276F8B2" modified="2023-09-13" version="1">MNSNENENENENEKLNENRIFIDQKNFNIQKDINNEMEIRNNPKKENNNENNNKIDNNDNSFSNFDIEDNWTPYSFTNLNLNNKSNFQQDPKILFDQTNTNTFNLLNKNLFIQFFNQIVELKNQNQNQKEKETLDEETIQKFIKFPSKTNLTLNAQIELSKLFQLIIFHCLKNLQGNIGCLKNLVLIFQKSTYSFDTVSYSSSNKIYKEKRDSYRNSPLQDFFKIYKEKLIKDPNPDNHTPDFNSALSSFNLDLNFNLDLNINQSQKIRFANLEENDDSNSLFLFENIQFFGSISGFDIFHNFISRINESQELVSIPFPLLLDYLKLSFTLYPFTEKNIQKDIFHTFFEKILLVITDKFINYDFSFQDLLYEIQITSSFISEILQDYMNSKLIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLT4</accession>
    <name>A0A9Q0LLT4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLT4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="210"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="272"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="62075" checksum="B610B4B6A1FE4AF0" modified="2023-09-13" version="1">MRSELYQEMFLSVTENTSNKVTDYSELNIITKPIQFKFENENENENENEKQIKQISSGEFSIIFLFKNGKAIEYLNENYSKQNPQKIQIKNIQKVTVGFENEAILTIEGNVFSKGEDINPNNPNEFINISSLIEDTNDRIIQDIVSGHQSIYLLTSNKNVYGIGSNSYSQLGFDSKTLEKTEKPILMMKNVSKIFSGNSSIHVFLLNSNQELFGCGWNEYGQLGLRKSRKKQTKIQKLTQIQNIPKGKIIDIQSGYWHSIILIENENENPKRKLYSCGNYRYNGLGKNENTYEFTEIKSSLFENNDNILDFSCGKYHNFILTSNSKLLGFGYNYYCQLGTGNTNDQPIPIQIELPKLRFNEDISNYHISCGSEKSFLYYSPFLSPFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLX0</accession>
    <name>A0A9Q0LLX0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLX0"/>
    <dbReference type="OrthoDB" id="287677at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="294" mass="34856" checksum="1F8071D8ABC14D6F" modified="2023-09-13" version="1">MEKTKPQLFHNEKKTISLNSGFIREINIIDQYSEIFKPLIKKYNTTISICGFIAPAVAFWIFDNLQTFPYLIDVNSVKRLIFSLLDPDNLVPYVEDAMKFIQNDRENYVKTHSNEFSTEKEKENYLRDWVANYEISDYIKYKANPNVIFSRFIERDFGPFSKLNHEEKRRLEEEVPFRKYKFFLDSPNPKKGEQNILQNPEEWLNENIKNENITKNENDSQIDWKSNKIIITDSTGHFTVSLPLILLQNQKKTNTLLVLNSLNYAVYSSQPLFKHLFELWFEGKIPPLYNSNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM02</accession>
    <name>A0A9Q0LM02_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin heavy chain non-muscle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM02"/>
    <dbReference type="OMA" id="NTHDITP"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="600"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="849" mass="101498" checksum="4B3738BEE577CB2C" modified="2023-09-13" version="1">MNPQNLSKLLNVSENIEKAQNNLFQGIDSLLIKSKNYLEFAKNNSQKNKNSQKEIAKISRKNEELQKEKEIYQEKIQQFEKQIQETDSNLKNSEDPNFLMQKTLLEKDKLQQENSFLQKQLKIIKMKNKQEKLQENTKELMDLNAKIDSLSQEKDNLKNQKEILESIIERFYQQNMSIRIEFNKLQKDLEILKMEKFKIDFFGKYEFESEEKKQVEISDLNLENKSFSQVCSEFLDQTIELNKKKLEIQKLQEIFWKFYRKLENKIVFLEEQKIQIEKLKESSQISNENLSKMVENSTKIKAENTELRQQLEHLKQETDILLSHNKELFESNLNGYKTNSDGNNQLTKIINENGIEKFEFTSLQELYAKFVEVSIQMKKFEEKKEEEIKNVERKLKEETQEEKNKLQKEIEILKQLSNQHLNIIQEQYEKLSKAGLIPKKTKFGEQNNNEFLKNELQNELLKFGINIDQLLEQDFDDKIYSKIDVNEKQLNPKKNDQISNEILLKNIFQLKKEKENLEKKYEESNKKMIEQEKIIKKQEKQIKKIQNQNHNQNQNQNQFDQTSEEIKLSKKAIDLLHQLLEAKKENQSLIKKGKITQKQIESQNSQLDLLRNKNVFLEKEVQDLNEKYKNQDEQKNIDEQKEFDEKEFDDGKLNEYRKRTLLTLLELKKFIAVISNDQFFDEKKTAKFITEKSSELETKIEEFSNLLISQLGFIDEKLVKLNDNFRQFIKKKEEEKIQMEKNQKEERLILFTKLIDSFNFLQNLKFFLLKSENIQIEKDLDIEKIFYCVKVSGIKLDDNSLEELKKLGNNFSNQEEKSIGTRKRFLSTNFTESLFDEKNRRIGKKNQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMC7</accession>
    <name>A0A9Q0LMC7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMC7"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="558"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="923"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1250" mass="146007" checksum="1AAB6BEAD3C1DD0D" modified="2023-09-13" version="1">MSTKKPRPLPKIKPRPLPKIEKNSKEQIDNNINNNINNNINKESPKEQIDNNINKESPKEQIENNINKESPKEQIENNINKNSSNQNISKPVRKTQRANFAEKKVLTNSLNQRPKLLSAEEFLSSVFKKDDLANIIPKKRVPTKQVIEKKEIDKKTETEKNVKNENDKEIKKEIVKNENENENDIKKEIVKNENENVKNDNPKKELTISIQTSAKSSPQTTPTQITPPANESLQTISPKIIDSHENNEHNISPQHKKNITTFLLPEDEPNNLSSPTKKMQKNEMTRKTQVLHHKKFGSRVSNLTQTKLSSNIRQNALNMLMDSSKRSNENKNEHQKNEHQKNENQKKKNNFEKISVNQKPKLMRPNSPRKEDNKVPEFPNNLNSTSRNRKFSITERIKNLTTSANTTQETQTRKRHDSVPHGNLQKLKQELQGKIGVMPPQIKNKSHDQEIRARSNSLDVDEAKTQTKSKSKSKKTPKIKNVFSKLIPSKNHEHDSTKSEKQKVLISPKETEKSPKNEKNKNQDKDQKESHQEEKKLKYPISITFEKDYNENYSKISQFPAIPLKILQNEKEFHDQMEVFNQKFLQPFENADILQEWQLETLFGKTKELIGHSQKTSLSLLSILESGPKISDAFKEYDIDLFKEVHEGYDDALYTMILLKKDHEDFQDLLEKCEKEIEKEYLDFIIIPLKYIKTFHRLIEDYMEDIERQNEDYPKITAFFKTLENVVDKNLVARVERYDNQYQLVEIQSNIEGLGDMEIVHPSRSFHNDGVLQKYMYPNQKLIDQHYYLFNDMMVLANIGKKGQLKFDMKIDYSSSIIRNLTPNQDDMKSKKEDESKEKNDGIIRTNQLKFTYAVEIYSEDTEQRYVFLFKAQHQHEQFWWYLTEVFFVRIQGSAVNESELVNDPNSNTLIQAPKGETTKTEKRGMIIGELIHTEQEYVQDLVTIQKIYMEEMLKKQLITQQESIQIFGNISRVHEVNEKLFTLMKGLLESMNNKPENLNVGKIFSFFADDLRVYTEYCTNQNTSNEAISKLSKKIEFLQYITDCQEKLTECKGLDLLDFLIKPIQRICKYPLLFKEILRSTSSEHEDYQDLAKAYLRLEEVAGYVNKNKKQSDSEKSLGEIASKIVGIEKHVILPNSNRKLILEDPNIKIYQKSKGVNVNMWIFNDLIVVAKQQKKGKFKFVDLIEIDQAIVKELLSLNYSFKIISFSGIKELNVQCRDKDQFYQVIDAVKTQIQQLSRERLINENNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPT2</accession>
    <name>A0A9Q0LPT2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Telomeric repeat-binding factor 1 terf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPT2"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="244"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="472" mass="56895" checksum="7DA0484885FCCE9E" modified="2023-09-13" version="1">MEFKKEIEYAFKMKRVSETIILQILLEHACVNEMKSLVDLIFKKKPDLIDDPLTSKETKRIWNLYQLISISCLEEFKQKKSLLIEVDDVKNNCFFREQIVLSLMREGSYQMKQGIKQFFEKNQVKGNLILQNKRLQIVSIYKTLKKLEQENNQDNPEKLANFIEKLNIQQSLKEFKNWIRSKLLKYSPTKIEEFGVKYQNFYLKELLDASTMTLKDFELVTSGQNDSKKLNRKDSPTKKPRKKRAKSKRVFWTDMETNYLIYGTQKHGVGKWSTILSDPTLKFHDKRKPHDLKDKWRNLIKRYSNNPNETQNQNQNQIQNQNQNQIENQNQIENQNQIQNQIQIENQIQIENQNQFQNQNQFQIENENQNQFQNQIENQFQIENQIENQIQNQNQNENQFQNQIQIENQIENQFQNQIQIENENQFQNQIEIQNEFIENIQKNIQNISKNQEMIYEEKQKRKSTQNKIKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ62</accession>
    <name>A0A9Q0LQ62_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ62"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="94" mass="11229" checksum="AFFE197F0C6DB5DC" modified="2023-09-13" version="1">MFSFFQSKYKNPQIEKIYKISPKEIDNFYKQMSEITTFCFKQCSYPKKKSGQLNDKEKECISNCMACYLESLKEVENQFLQIIQSLISEQLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQU3</accession>
    <name>A0A9Q0LQU3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQU3"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="881" mass="101655" checksum="D021B1905A58F94E" modified="2023-09-13" version="1">MTDWNPDEKTLLEIHNLLINMQQGNTETQLRVLQDLEQLNQTLVDLNNYFVFVLVQLKQESMMNRQFAGLTLKNNLRKTPKEFLTQILEYVKHQLVFGLMDENIKIRTTCGIVISNITYNYGFHNWPNLVNYLAELLENDSEFAVDGALDCFHKLCEENSNEYETDFLEVDLEVILPKLLVFFFHSNERFRILSLSSFIELLMLMPGELITIMDQFIQNVFKIAQDESIEIRKRVCRVFCLLLKIRTAYLLPFIGDVIQYMLITTQDESPELALEACEFWSFFEDVEDAMTLLTPFMNDLVPLLLQKMIFTENEIEEYIETGEIENPEQNQNQNQQELKFDQEKETQSDDDFGKADYDYTNESQGKWNLRKSSANALETLSYIFADDLLQYLLSHLETNLQNENWIVQEAAVLALGAIAPGCYSGMISSLNQVLTFLIPLMKNENPLLSSITCWTISRYSEWIVDFPSFLSCSLSQQRRVQYAACSSLNSFIVYSGKKIIPFLNDILQVLNQALRKYNQKNRTYLYVLISCVAETAGEELNKQEYIELLMDPLIKQWEKLKDFDFELIAIFETFSTLAVSLKQGFLPFAQPFFTRCMNVIEEILNTYQMAAQSKEETFKGFIPDQGFLNSSLELIGSIIEGLPGNPEIQKMILDSHFTQMIPYLLKDIKSETRQSTLALLGATISSFPKIILPQVPELLPLLIHLLDPSYIFVSQNASWVIGELAMNLPDSIESKLDEIISYLVQIINKLSQSRSVIESVSITIGRLSLTFPQQMASRLQEFLENWSVTLRSIEIPKEKETAYRGLCNLAQINPDVTVSNFVYFCDAILSYTNPSVELNQAFYTILHSFKSELQNHSQWNSLFSSLHPRMKEDLGKRFDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQY3</accession>
    <name>A0A9Q0LQY3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear pore complex protein nup133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQY3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="933" mass="111011" checksum="8061E39A0B796EFA" modified="2023-09-13" version="1">MNKKNNEKFSNQNENELENDLENELEIDLENQNQNQNQNQNQNQLENELENELENQNQNELENELENELENEIELENDLENELIENLLIKKLNHSNQVQDFLSKFNSKDFQFNLQNNFLASLNEKSTIWIWDILSKEETLKIEKNQNKDVYLQEKESILDSKEKITSAISCLDHKSQNNTIYEEIILLGTSLGNLDLVFLKSNKENIFTISINRFGKLNLLKNLFNLLLSPFFGKNDQNSQSNSQPIIRLLQNQNQIFVLKSKDFQLFQLNLEKEEPNLLKKWEINIKKQISNQLNQNLEDEKDKTQIKLLDFQILNQNIFILFQILNDLQKQNFSVAQFVFKEEEIIFQNNYKIYVSFPPNNFNLNLEKLQFYALESKKEENLFIQIITTPEIIITSTIQNLKEVKTDQIVFGNEENFVLGSQKIDDSIFIVTQKYVYQIKENENENENENESEINIESDIESDNESDNENIINIAFQLYKNNDQENLQKIISSHKIFKQSKENNENTQNYKQLFDFISQFFSEKNQQSKKLEDVFLLNDFLKEYNLLSKLDQKTIQSILEFEEKIAITSQILNHFNENRNDLIYYEMVSILDLDLNKKNKQNYIDFLKTHFANPSEITKNINKIINAVQRNKKDWLEKKYINRIEDLNKIILLIIFVGKTFYLRFVEFFFDINVSDLGKDFPKNFSNDHMEELLFLKLIQSSNLNQLYIFSHEFNVCAKKCWKITAKIIQTLQKKQRNHLQKIQTHDLIQQFVSLSDFLFVKFTKENLPVLIPKKHKILKSLVCLKLEEEALFLSEKYEDFDSITFVCDYTKKPELVGKYLEKYLEKNGKEEMNFFSETVFRYLIQNKKIHSTFDLNSKYPDQFQNFVLKYPIESFSMLWRIEFKLSEYEKASNILSQESEIQKENLSLSEIYTNLSNLSQFANNLQNRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRH4</accession>
    <name>A0A9Q0LRH4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secretion-regulating guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRH4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="497"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="571" mass="67329" checksum="B7C09F3E32656F1A" modified="2023-09-13" version="1">MKSKRKLKKQNRKKNRKQNQNQNQNQNQNINQNQNQNINQMNDIFFFGENNVSQLLVSEKIKEPIQFKFGNENENENEKQIKQISSSDFSTIFLFKNGKAIEYTIEKVNPAKIQIENIQKVTVGYRNEAILTKKEIIIEDIVSGNRSIYLLTSNQNAYGIGLNDWSQLGFDYETLKKTEKPILMMNNVSKIFSSNSSDSVFLLDSNQRLFACGNNQFSQLGLGKSRKGERKIKKLTKIQNIPKGKIIDIQSGYLHSIMLIENEDENQNPKRKLYSCGYSRFNEYDEYEDENTYEFTEIKSSLFENDDNILEFSVGYEHTLILTSKEKLIGFGNNSHGQLGTEKIRYYQQIPIQIELPKLRFNEDLSNYHISCGYHNSFLYYSPPISNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEIIYSNNSKIKPKLYFEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIQITQEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRS7</accession>
    <name>A0A9Q0LRS7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_00057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="SLCICVG"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="12">
        <location>
            <begin position="1322"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="2408"/>
            <end position="2719"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="13">
        <location>
            <begin position="2745"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1768"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2015"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1768"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2015"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2073"/>
            <end position="2088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2091"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2118"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2152"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="2166"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="2207"/>
            <end position="2225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5076740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2777" mass="319971" checksum="78C22E4EC4582639" modified="2023-09-13" version="1">MDSNEEILRFIEDIRTANGNKQKESLTKLRSHLEEQISQLNRAESRILMSNLNKKVSQFTKSTEANDQLIAVVLMEEIMEINDESTTSNNLVLFFNLLKNVLNRQNNDLNLIEKTTQVLAKLIKSGGALSSDRNEARRYTAILLFTKFSEIVSTLVFVHIRHFLDLIWVALRDPSETIRTLAVNSLHPCFEVLKLRNMAGLSEIYNSLYQEALKSFRQNIIEYVHGSLLVIRELLTCSDRFMESHLEEICTIIFRFKTSKAKIIRETIVDLIPQLARFSPHFFQERYLDSIMTYLYTVYKRDSVLKNKIFETIGELALIFQSNIEKHIPEIMKRIQLSMAPNKKKTYCELSMSCLSKVAKFSDIRGYLNSFKIIDTMIESPLNQTKINSLFELTSSIPDIEMEIKFKLLNLLSFILTSKPYKMPSFLYIEKLKIGLSNDFKQQDAYQTNPQSKMEQILLAFKTFRKFRFGELLRPKFIYRGIVSFFQDENPKLRLKSAKTCIDLICENQISGEKEIHFIFNKLLSLGITDSEGYIRQKILSKLATKLRTHLAQSENVQYLMLALYDEVFQIRKLVIVTLSQLAEHNPAEVIPTLRTTLISLLTEFEYSQEFAVKERSIHLIVEIAKISKKLIYPYCDAILQVFIPKLHENSKSVNSLIIEHLLSAIGSIVVIGGEQMKKYVDELLPLIIETFQKQGVQTRYITLQTLAQLIQSTGSVIDPYKKFPRFLPMLLKTIKTENHLGIRREAIKVIGMIGALDPYKFKMNQTNLQFTGTNMEKAEMMNMPGMDNKEQTMQMQSGITNTNTTTSMSRKTTGEIGFEGISKPNDSKINTNMQTIQTSTNTWNDNSVNAIIQVATISGDVNEEKAPKQTGEDADFQDTNEMTRYFADIANNNLDEFYAKVSISALMKIISDSSLGNHHEVAAQSLLRIINYLGEGSIPFLRQILAPFFEAVQKSDSISKEFLFQQFTQLVLHLRQHISPHLEEIVKFIFGNWQTAYLAQILELIEKLVQVFPDEVTTFLPVLVPLLIGVLRDDRSEHRDHVLRTLQCVEILAPRLGDYLQLVVPVVLEIAEKKRNDPSLCVAAVNAISALSDRQGFADFSSRIVRIFLSLIPNSGEEVRKYVIEGLNIFSGTLGPLFRVFLPGIERIFMFSGISKEEYMRIAEKSVSANKNNEMTLTQKNNRTNTREERMGFGALAFRKIPLNAGNLKHSWQAQNSFTKEDWEEWMRRFSGELVRESPSPAIRSCSDLVQSYHAPARALFNAAFLSCWMDLLDHHKDDLAEQFECAFRSHTIPQDILQTLLNLAEFMEHVQQPLPLSVSVLASIAENCHAFAKALRYRELELGENTTSAIEAIISLSNKLQMPETAIGIIEYAKQAHSIEPKESWFEEMNQIEEALSAYERKQLADPLSLDLMIGRMRCLYSLGEWEKLIQISHEAGNFPEAQMSYTFTTLVADASWMTNNWALMKKCSNSLPERSAQGAFLRAVVDVKFQEFESARKHIDIAREMIIDSISALVGESYSRAYSDIIRAQQLAELEEVIEYMQSDPHPSHRAFIRGVWRRRLKGCERSVDSWLRILAIRSIVIDKRDDVLSWFKFARISERNSRKKLAEKTIRATLRMSREALDPNDIDSQKNPLTSDIDRFEITLDSDHVIRQSNNFDINAKISPSFQKRDSETNTFSFFSQNISNLSTPPQLPISGVRMQTQISELFAENPKAGFQYLHHLWDLGHPKDAFEGLKHFVQHLSALTSDSNIQFSHGRTRIKDSLRTHNLERIRERSNDHKNSRNTNKDQDRNHDHLQDHDPNQDNESEQEVDLRHLSAKVYLQLGKWQLALQTPQQDGRVDEETALNVLDVYRKAMNSDPSWAKAWHAWALLNFEIVSRFEADKRTLSSQDIHTYLLPAISGFFRAIHLSSASKSIRDTLRLLTLWFRYGSYSKVISALKNGFSMVSITIWLQVIPQLIARINSTSRPIKQLIHNLLIQIGKAHPQALVYSLTVAEKFQEYEARLSYDKGIRSQDSEPSLDRSLRHDSSFSPNNKLVDSDDSDDSDISQESRSPTDSLLKSSHSRNLSDFDSDDDDDDNDNDYSIDNESTNTNESYTSNDLDSNEQEKNSSVDQNDSDQEDTDFEDSDEDEDEYENENDENDRNDDNFRQQIPRSKNQLKLSQHYHKMKKSTNQKKKKKKHSTPKIQKQGGLVRSKPQNFSKFTKTKKQTKKNHKTKHKKNVRSPFRSTHNVREDLSDAGKIMESIKRHSPNLAEQAKLVSNELIRVAILWEEKWYESLDDASKIYFSEPKNFRGMMAILRPLHDELKKGGETAHENKFLQLYRTELDLALKNCEEFARTQNQVLINRAWESYYRAFRRFAREIPTIRLLDLKQVSPRLLEAKHLELAVPGTYNINSHIVRIDSFVEKISVLKTKQRPRKLKIRGSDGSSYQFLLKGHEDLRQDERVMQLFGLVNALLSNSFQTSRLHLGIQRYAVVPLSPNTGLIGWVPHCDTLHDLIRDYRESHNIVLNLEHQLMTQMAPDYDKLALIQKIEVFGHSLQNTDGLDLNRILWLKSQNSEVWLDKRTNYTRSLAVMSMVGYILGLGDRHPSNIMMNKFSGKITHIDFGDCFEVAMIRQQYPEKIPFRLTRMLVKAMEMSGIEGTFKETCKHVMTILRKNKDSLMAMLEAFVYDPLFSWLFEQSLKFGTDTKKPIRTESEKSSFDRTFSNFNLSTTEAPNQKALDIIDRISNKLNGRDFRKDTRLDPQKQIELLIQQATSHENLCQCYIGWCPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS03</accession>
    <name>A0A9Q0LS03_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS03"/>
    <dbReference type="OMA" id="NNETILM"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="764" mass="91264" checksum="D0209B9E8037FC7B" modified="2023-09-13" version="1">MTSDYKEELQKLQNHQIQELTEQWKLEAEKVQIWKNKYKTNMQKLKQNLISMTELQQQNIKVINEREALKLEKIHYQKKVSEEKIQNQKLINQNQRLQSKIKEFEKKIISDFSKSTIQNVFNKILSKHESNEKNSHRNDNKEVHDQNKSSNTSIEEMDKRIKLFSISNQLLRDKVADLDRKYSTKKNKYHKKKQKMNETINQLKNKIDEMNQNHKIETEELAKKNESISKEAKINLSKLNTKKFEMNQLEKSYQNLQNSTETKFKELQEQLEQSRQNEAKDAIQKSNLEQIVNQQKVQISNLETDFVRIYKKQQKEIQKSSKNEELNKIKEKYAQAMVLNKQFLEQISKLNSFLSEVENIQKLQQDQTSWINKEKILIQKEADKVISSKKLQETHNSLLNQQTQELEKIIEISKQILFNAENKFASEIQGLKDENQKIKLKLEEKKLRITELEIAFESSSSRNKEMKDQISQLESKNSQLENSIFELKIGHSNELIKIDTINREQINKLYEEKEQYLELEKEKFQKKKKELQNKILLLESYLQKTEKEVDHFRNECLTLECDLKQNLSRDLVNSVISSCLMKNMEKEFINQKEQNEKKHKEIQKTLNIENENLSKKLDSFQKLIDLDFNPKINEQKNKILQLEHLLKISQQKETTSKLSNKLILNQTKNQFEELIVIFEENYQNLEKNIEMKIGLIENQFERIKKFLIEMKNKQNQETNQEINQEINQEINQETNQEINQETNQEINQLALHLDLMSLLLYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS50</accession>
    <name>A0A9Q0LS50_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS50"/>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="122"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="234" mass="28450" checksum="201821395E8A7C6D" modified="2023-09-13" version="1">MNEPLNKNYRNNYNNSHYNRRKYDRREEKDEFLESRRKTREKLYGKSKLKLKEKIKKIEIERKNNQNENENQNERKNQKRKKTEKWIEKKVELPFNEKDFYKEETKEEEETLGPKPINVLVDYGKALMPGEAQAYAEYVKQNRRIPRRGEVGLTSEEIERFENLGYVMSGSRHQRMNAVRLRKESQIYNAEEQRALALLNYQERLKKEKILLNEFRDLIDSKTEKIKKSSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT37</accession>
    <name>A0A9Q0LT37_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT37"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5078472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="313" mass="36614" checksum="42BCD80327AA4405" modified="2023-09-13" version="1">MRSEEIATLIGSILAILGALCIIIIYLYFKETKIFYRKLIFVLSVYDLLQSLTFVLPGQKGSGICRTQFTLVALFATTSQYWSAAISILSYLKVVKSFHEKFLHKLYIFFHIFMWVTVTPLFILSFFLPNPNKSGTYWCISTSEKYLIPLYAFNWFYLLVCLVFCILIFIRLKKFYQQNIKGNYNKRISQLNKFWIELRMSFVPLIYIIIFIPTSFRRIRNLAYPNASEITFIDVLQGLLSISQGFWDFLIFVIFDPEIRTKLTKKIPQKNQSFEKISSFQNFTENNINESLIGDGKNLTEVSQDLNLNSDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTC4</accession>
    <name>A0A9Q0LTC4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTC4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="279"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="386" mass="45266" checksum="61F144C3708954CF" modified="2023-09-13" version="1">MFLKCFQEKFADHAFLLNSNQELFGFGNNATGQIGLGRRSNNNKISEKFAKLKKKIPKGKIIDIQCGYSHSIIQHESKFTEITSPLFDDNSILEISVGRYHTLILTTNKKLLGFGSNDYGQLRFENTAPQPIPIQIDLPYLAFEDISNYRICCGYSNSFLYYSLSFSNLEEDLIKLCKRKEFCDISFKTQDGEIIEAHKLILKYRLKDQNENQIEKLKQIISQKSIQESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTDDTSNKVTDYSELSNESFQILEYWIYSNQIKEGIQITKEIIDELETGIDYFQLNQTNPNLLDLLINKFQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTN6</accession>
    <name>A0A9Q0LTN6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTN6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="940" mass="108625" checksum="9163FD764DE09D54" modified="2023-09-13" version="1">MILANISFSNQKNQDEILEKKGIETIINSMNNFPNNKEIQFIGCTVLVNIKLENQRNEILEKKGIELVIKAMNNFQNHEGIQVYGCEILRKLIVGSGRNLNEIIKQNGIETIINSLNNFPNDESIQAIGSLILSMISLQNEKNQNEILEKKGIETIIKSMDNFPNNQDIQFIGCKTLGIISFENEKNLNEILEKKGIKTIIKAMNNFPNNQEIQTIGSLILSMISLQNEKNQNEIREKKGIETIIKSMDNFPNNQDIQFIGCKTLGIISFGNEKNQNEIIEKKGIKTVIKAMNNFPNNQEIQTYGCGILMKNQNEILEKKGIESIIKSMNNFPNNQEIQNYGCKTLLNLCSDEKKEIKEILKSFQTENSKKISIQKLFEIMKQFPLNETIQQISFFICKRFIEKSLKNEKILKEQEFEIEPFIKAMNNFPNNQNIQFIGSITLAFIGFENEKNQNEIREKKGIETIIKSMNNFPNDKDIQDNGCMTLSYISSQNERNQNEIREKKGIETIIKAINNFPNDKDIQMNGFLILGEIGYRNERNQNEIRVKKGIETIIKSMNNFPNDEDIQMNGFIVLRNLSLQNRENQNEIGEKNGIELIIKAMNNFPNNQNIQIFGCMNLANISLQHEENQNEIREKKGIETIIKSMNNFPNDKDIQMNGFIVLGNISFQNEKNQNEIREKNGIETIIKAMNNFPNDKDIQKIGCSTLGFIDYENEKNQNEIIKKGGIETIIKSMNNFPNDKDIQIFGCITLGFIDYGNEKNQTEIIEQKGIETIIKSMNNFSKDEQFQFISTKTLMKISSRNEKNQNEIREKGGIETIIKSMNNFPNNQYIQMTGCGILMNFSDLNKKKTKTEKEIEMEKLSNRFKRFSFKYQKEKKGIETIIKSMNNFPNNQEIQIYGCKTLLNLCSNEKNKNEIKRLKGIEIIQKLMINFLMIKIFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTS8</accession>
    <name>A0A9Q0LTS8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTS8"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="637"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="766" mass="89645" checksum="F9FABBCCDA2BB9DB" modified="2023-09-13" version="1">MDFWNEVHKGNFSNLKLFIEENPSYCQLKNGLSILDHAFRCNQSYEMISYLIEKGARLTIFDIPFTSLNFEQKIIDLIFNSHKFGIDELNLILISQFKNEKTPIKLIEIILKKGANPNIENKTTPLFYLLNNQKYEGDNNKEERLNKLQLLIKYGVDVNKTNPGLRPLNFVLSSNLGYEFVELLSKSGANWEKEDFDIIPSRFLYSIEYVKLFCEKIPDINYVNENETILHKVLRNYPGPNKEIVIILLEAGANPNLQNKGFTGLHIIVSSYYNEDIFRLLLKYGADISIKNNKGETPLDLIASGSSYSSNFSERFHILEEFGYKFDFNEKPPYIFRCFRYNSHQPKSFEVIKKLVALGADINEVHDGNCILNLFNPYSVDISDLKTLFDLGFDYKKLKGKISDNPIAVRYGYSSRNQVSLEKFKLLVEKGFPIEFDSHKPIIFEFLSFANPKEALETILDCGLNPNIHNYNNQGIFSWIYDKIKNRADFFKILIDGGIDIESQKKDSSFKKMEAKYIDLIEKYGSIMEDFNELFKRKEFCDFNIAVEDGTIQTHKLILEMRIGKEKITKFLEKCETKNQEEIKPLVQFIYSGLANGNEYEKIVNLCEEFEIDFNKKKGKKGIIEDLKKLYEDEESKDFTFKFDEKNQFKVHKLILITRSELFRNMFLSVNDSSNCVQNYSSFSLKSLQIFFEYLYTDQISFQPSLFLMRELKTIPIYFQLNPKSYLSLQIEEIRYYLRSKLFHPDKVKQNPKPEKKHANPDHDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTV7</accession>
    <name>A0A9Q0LTV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding protein nob1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTV7"/>
    <dbReference type="OMA" id="QSWMVRS"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="7">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="6">
        <location>
            <begin position="512"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="642"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="657" mass="76668" checksum="4E9B2A3683428AE0" modified="2023-09-13" version="1">MSIRDPEKDDYVVIDTGAFIQGVKLENISSQLFTVQEVLDEIKDTKARRLLQSLAFPLQIKEPHPDSIKTIVNFAKSTGDFAGLSTTDIKVLALTLQLEIELNGKNHLRTEPKEYGDFVDNLESNQKESNQKESTQKESNQKELNQKESNQKELNPKESNQKELNQKESNQKELNQKELNQKELNQKELNQKDSEKDSKKDSEKDSKKDSEKDSKKDSEKDLEKDSKKELEKELEKDLEKDLEKDLEKDSKKDLEKDSEKDLEKDSEKESKKESEKELEKELEKDSEKELEKDLEKDLEKDSKKDLEKDSKKDSKKDSKKDSKKDLEKDTKKDSKKDSEKDLEKDLEKDSKKDLEKDSKKHLEKDLEKDSKKDSKKDLEKDSKKELEKELEKDSKKDSKKDLEKDSKKELEKELEKDSKKDSKKDSKKDLEKDLEKELEKELEKDLEKDTPKFNDFNGDWITPSNIKQIQAKKISPSKFTRQAACITTDFAMQNVLLQMGLKLLTVGGIQMRRTKRWAMICTACQRISNDMNRVFCDFCGNHTMEKISFHIDKNGEKHFHQISSKALSKKGKKYPLPKPKGGRYEKKIILVEDTMPSFGKHKNKKFNKTNFFDPDHEFFQSHKINLNQKVEIGTPKKNPNIAKRRYGKKKKGRNQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU39</accession>
    <name>A0A9Q0LU39_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Palmitoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000018">
        <property type="protein sequence ID" value="KAJ5080001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU39"/>
    <dbReference type="OMA" id="EHGNTIY"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053215">
        <property type="entry name" value="TKL_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45756">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45756:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="371"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="450" mass="52562" checksum="84A94069B3B1E9C0" modified="2023-09-13" version="1">MESKPFSCQICFEEYSKERKPMIVCKEGHSVCEHCLKKIDSCPFCRSSFENFESILNRDLLQSVEEMKEKKKLSNVPIIPLSELKVAKESFALGGSADIYKAKWGNNLVALKKMRIQTNQKLRNQFENELQLAVKLNHPNIIKIYGMVEYKKSFGILMEFGEQGNLEQKIPKLSLSKKIDYSLKIIDGIKYLHLNSIIHRDLKPQNILISNDQPKICDFGLSKIHEHTMKNTTAFVSFGYSAPELFQQGSIYDSSCDIFSLSMILFQMFSKKKPFQDENAFDIPQKIKQGERPEFPNHFPKELIEVIKKGWNQNPKERCSLNEFIQCLDQLKRKRRRVNGITKKEEIEKTEEIQIKEEIEKTEEIQIIPQFQIFVKDLHGKSFSFFVDYEETVEDFMNEVYQNLGIPKEQQRLILKGKQMRIGKKFKDYPIEHGNTIYLVLRTPGGLFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU49</accession>
    <name>A0A9Q0LU49_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000016">
        <property type="protein sequence ID" value="KAJ5080016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU49"/>
    <dbReference type="OrthoDB" id="5573735at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040286473" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="479"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="4">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5080016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="100018" checksum="42D14AB057DF0EE7" modified="2023-09-13" version="1">MKLILFFSFFLIINIFLIKSNQNQNQNQNQNQNQNQNQNQNQNQNQNQKSIPSLIPTLKETETTRYYSTPDEAWIWNLLDQFSASGFFGHSVSVYKDILVIGAYGANKAYIYRYNGTNFELEQILSGPSYFGLSVSVYEDVIVIGSTDVTKAYIYRYNGTFWNEEQILYESVSYFGQSVSVYENVTVVGTIANKTYIYRYNGTFWNEEQTLYESSSYFGYSVSIYGNVIVIGTWDVKQVFIYRYNGTNFELEQTLSGPSYFGYSVSIYGNVIVIGAWDAKQVFIYRYNGSIWNEEQILSEPSISRFGYSVSVYEDVIAIGASGANKAFIYRYNGSFWNQEKNLSQPSATEFGYPVSIYGNFTVIGTFMANQAFVYEASLIPQVNIVNCSSLFSSFDCYWDKIQFPSTLIYQINYGYNWIDIDYPILENENVYYQQFNSSFYDNITGNEYYSIQIKACDNESMICGESSSFINLTSKIDSVKDFQLSNPSNYSINVTWNYPNVQIDEGIAHLDHYNLSYFIQSQPDLISFISVENSSLDYFLNNLESENDYNISICGCRTLKCEGDDKGEIVESSISLLFEEVTNLTCSISNLFDINFQFPNQEYQINISACNSNGKCGYISSISIITDNLTSPIIYETISKIEEIEFNFTKLTNANNYSISLDNGTNWQKFTSLDLSGNEVIGIISEISGNIEYNISIRGCVDLNCETLYLGLPSSIISTRAKLGNITSLNCISLINGFFCNWNSLILSSGLKAYSFTFNSISVCLTTLFNYYLIPSGLNGGEYYEISVQQSSTLNCLNNEYSGINSTTSITTLSPYQPTQTTDNSNNSNTTAITVGILVPIIAILIIIIGILLYKKTTRKKQSKNQNQKQEEKELQDNLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUA4</accession>
    <name>A0A9Q0LUA4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUA4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="466" mass="55117" checksum="86F332CC0A65D79B" modified="2023-09-13" version="1">MNQIKKKFLENGLKSVENMNDEELLHFIIQNIQNIQNIQNSEKQNMLLSQSSREKQKQLEEKLREAQNNIDILNQVKEHLNQKNQMKKKQLINLVSFFSEELEAIYKISLQIISERNTENVYKQDSNNFLIRQVSDLSNQNQNLQNQLRQSHKFAQEKQHKIDQLNQELDKHKELNQKTNQELQLSFLENEKLKNKLEHIQLFYNKNEQNFQKELNAKDVEIFRLKKIIDQNQDEQLNFVGNKSNSKKFRNPQVVQVTSKLNPFFPSRKNNLIDMNSISTSSSLFLENSQDVNSFYQSKYPNSNLNPNSNLNQNQFKNQNQNQFKNQNQFFDENKIHNRFVNQFDSRSISNSISNSNTNSLTNSITNSINQHLPKQIIPNDPNIKRNLYRNIFRSISDGSLERNGIVFYQQNSQKKKQPIPIRNPKEFELKFSNDQNNTTKTQDLLESVAQEKAFLEQMEQKFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUT4</accession>
    <name>A0A9Q0LUT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUT4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="349" mass="41268" checksum="234326A5AA428369" modified="2023-09-13" version="1">MNSIEKKAKISTENLKKVEKEMPNELEKINQISKELDSNLSSEDNLDKILNEIFNEISELENSIKSLKTELSFEDNFWSSNYSNHLISDLKRIQKEKHDFFQKKTDFLRISSDFDQLNQLALPKGIEIKIIKENNLENNFQSDFSDQMQIENLGSNYFVHGIAGNYFWNILYSYNQEKQEINQIKFQIERKEMNDDFNENQQVNHFIEKKDEEIENLIDVSLKRKSVDIFLNGLSLLSRFDLKRNALFEKISQFASDNLIFSFDNPSQFSVQSNSSPFGFHFYWIARFNCFGRMTKEYKIIPIFIEKVRKIDKKNIIQDFEPNFLNLIKTEGLENALKICVELVQKFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUV6</accession>
    <name>A0A9Q0LUV6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein aatf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUV6"/>
    <dbReference type="OMA" id="INFMAPN"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="4">
        <location>
            <begin position="170"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="3">
        <location>
            <begin position="396"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="473" mass="55426" checksum="9C7631FE0BD36726" modified="2023-09-13" version="1">MSSLKDELNNLLNPKPKDFNPDDVDGFENYAQKQSLQNNQNTFDNEISDDFTLTRIPGKTLSSGIELSSGIYEGKKISRKELEDSDDSLEFEEQNILDNIDSDSSIESIDDSEYSSEFENQNENQNENQNENQLKNSNQKINQNFTQQLKQIQQQEQKTLEEMKIDNQKEMEKANAAFNQRKLWNHSLNLRILLQKILKISNEFPDPKLLAIILDDQAIQNQAQNSQKFILKILSDLIQFKFNLTKQNNSILKQEFQKEIEGNFEELIELCRKFEKKEEEISSEKIWGKFSQILNKMEPIENGILDKWNRKTQIATGHLLSKKFKSLNQSVLTQIDNILKDKERLVKRTQLKRANYEIIGEEMIKKKKTQKNAKESFRKQNEDQYNEQIFDDLDFYQKILKNFIQNSSNQEGFDSVNAVIQSRKNKPKKAVDRKSSKGRQIRYVVHEKLVNFMTPTNAQENEISKNLLNSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUW4</accession>
    <name>A0A9Q0LUW4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="128"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="489"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="532"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="575"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="618"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="661"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="705"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="748"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="878"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="363"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1322" mass="152210" checksum="DDE5E6117696AF06" modified="2023-09-13" version="1">MKIQNENQIENENENENQIENQNENQNENENENENQNENQIQNQNENENENQIQNQNQNQNQNQNQNQNQIENQNQNQNQNENEKNENENEKIRISKLYQFHSQKLNQLLLSELLLNYKIMFQNEENCDFTIYVGNKKEKILCHKIILNSRSRFFYEKNHEIIDNEELYLPKFEIDIVKPIISFLYDSEFKLDLNKFEKYFKLAKHFKLTILKIKIEKEVSEQINEKNVIQIYFKSISIESRFLSNFCEIFIKENIPKIIEEDQIGEINDTKIREIIKIIQKTPKEKRIDLIWELSKDWEKKFKKNKKNLIDKYKYIDPIQIQTIKYDITKFHDIISNIKNSGYISSDLTTRKNPILPSTDQFELMVQKNRELKQENEKQNKELKKIHKTNQEKDQEIIEKENKIQKQKNKITQMEKELQTFQPARNAEKTLEDFVNQTSNLTETSIQQTIKFMNYFPLDQNIQENGSFILQKFATENEKNQNQIRELNGIELIIKSMNNFPNNEDIQIKGCGALLNICFNAENQNQIRELNGIEPIIKSMNNFPNNQDIQFYGCGALWNICFNDQNQIEISKLKGIKTIIKAMNNFPNNQDIQIKACGALLNIGLNDQNQIEISKLNGIETIIKAMNNFPNNQIIQIQACGALLNIAMNEENKIQIRKLHGIETIIKAMNNFPNNEDIQIKGSGALGNISSNNNENQIQIRKLNGIETIIKSMNNFPNNEDIQFQACGALLVIALNYENQIEIRKLNGIETIIKSMNNFSNNQDIQLKGCGALLNIALNYENKIEIRKHQGIETIIKAMNNFPNNEDIQFQGSENLTNIALVYENQIEIRKLNGIEPIIKAMNNFSNNEGIQNRGCGALLSISYNNNENQIEIRKLNGIETIIKAMNNFSNNEGIQIKGSGALGNIAYNDENQIEISKLNGIEPIIKAMNNFPNNQDIQIRGCGALLNIAMNEDIQKNGCWTLGNIAINEENQIEIYNLKGIEPIIKAMNNFPNNEDIQNRGCAALLSLANNNQNQNRIRELNGIEPIIKTMNNLSDNENIQVTGCGFLLNIASNNDENQIEIRKLNGIETVIKTMNNLSKNEDIQIRGCGFLLTIAVNNKENQNRIRELNGIEPIIKAMNNFPNNEDIQENGCWALGNISFNNAKNQNEILKLNGIETAIKAMNNFPNNEDIQIKGSWTLLSFANNEENKTKIRELNGIETVIKAMNNFPNNEDIQIRGCGIVLNISSNNKENKTKIRELNGIETVIKAMNNFPNNGDIQHYGCWVLLNIGSNNNENQIEINKLKGIESIIKAMNKFQNNQDIQLKGCGALGIIVNNEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV84</accession>
    <name>A0A9Q0LV84_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_14578</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="JAPDFW010000036">
        <property type="protein sequence ID" value="KAJ5079144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="13">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1438"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1489"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1560"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1070"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1496"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1507"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5079144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2086" mass="244644" checksum="45743891214776E4" modified="2023-09-13" version="1">MEEEFSKIPKISKTKKETAYSLSQSPEFISEFIEKLIAQQREQNEIEELTEWLNWILSGGEEPEEYIAELRRKCAKNTGICGESWKEGEICYKCRTCGLHPTSAICVKCFLAGNHEGHDYYCVKGGLGMCDCGDDQSWRHSGFCHFHKGLPENPENLLDNRLKVRAPFIIRSVLGFLINLFYKRLIEMSHFVDFSSYQNLNLQNQNQNQNQNQNQNHLQNQNQNQFQNDLNQNQNQNQNQNQNQLQNQNQFQNDLNQNQNLNQNLNQNQFQNDLNQNQFQNDLNQNQFQNDLNQNDLNQFSIDEYTLFDNVSSSEFHKNRHEIIVLLKWLQNFISFDNGLRRLTSIEFVQQSASSKFIDSGNEMSVLEFLMRLSYLEEGPIFQALISFWYKAISDISFKKEFFKSYIKIYQVMFHRKMHKIALHPLEKDFSQFSVQLFNVPKFSPEFCEKYNFIDILFETMTEILDEICTPLNRNNGREIEFEENSVEGENQEDSDQLTGHNLEGNNSISFTFDENNPNPNSIDANSLPHLINSQIFNLADSHLKNINLRHPIITSKKIWFIIIDLKYALRDYYSSQFVMMKKQNLFEKFLQFFVCLEGMHMIKRETSSHVAYEDMLWENAFHLAFYHNSLVSLLNKGFLCGENIFTPPVKFDEATKRGQLTETLMSKISNIFKTIISTNIEWIIDNNAVYNDLHQCVVCVPQSLDSPRERIQYQIYSYDISTQPISMHYPLQRILATFAISAVKQWDLTFPSLFQETSIYSEQYLDTFILLVIHVIRLQAVFSQISHNFWVRNGSSVQKQMDMHRHPKYYMHFIDKDISLLQIAAVVMDPQKLLLSILDAFQLDNFWNFGSNKSKKNANIELQTLMAGDFLKLLIIILIERANSGVLNSRAILRREIIHQLCYYPQSHSNLHKIIDEDIFSDQEFESILQEVAFFNEKQHTFSLKPEFWKEFEGQYFPHFTQKVSQKAEENYMDFIKLHNARFSTSKIPEIYPSPRYTPTHPSFQNLPKILHNHLMHQILFTVLYNSVEQNKSFSEELLNYALHLIRFSLTIENSFMGNSDKNIQNSKDQNKDNEKEHLKNEKNDSLFKKNSIIVPNNIRFPTYNDLFRNSIFPVETPKGKITFISLLINLYKLQLNKENEILVSEILKIFQSKSLECKSIIQKQLPQFLDNKQIMKEEEEKRKRKIEEKQRMILTQNRLKMKQFTQKHSNEFMEMDVEHEVTQKLKLVGDKNNISTWTVFDHSISQLSYDEKIIHLRCSLCKDDQPYNDSRPLGLVCYIHLSNIHDIVSHKFISQKRGTSFNYSNTRSRLYLISCGHLMHIECYQGYISSLISNQMRRLAFDGMDLINLAKNQFLCPMDRSVANTLLPIIPSYIFKPKDINNNQNLNQNQNLNQNQNQNLNQNQNQNQIQNLNLIPKQIPNMFPNSQISSSIFSNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQSIFSNQSIFSNSPQKRSLMKNSNFNSNIKKSSNRNRIRKQKKQKAKSNIMKDLNLNLNSKSKSKSNMDTNTNMDIVENFKSIPQNIPKLPPLSHKEESRKQKKPFLFKKTDNSIKLESNAPLQKIQKNYRKISIEKKKQTTINFFEETIKFFEENQKKPRQTTILENIPDSIRDSIDTFIRNLDFCLSDDSNLEPSYATEKGFCLACELLSNTLSIFEISTRNQENQSLDETQKFQLQSIYRICVVLSKETNYGMKFQQELKNKIWKFIFEGVSFDVDSESLLSGDIVFYFIVLSILFNNEIEESKCFIELSKLFFYPLLYQIIIYSISVDESIQQKYPLLLNNCKSISDQDKMQKAVDIAKEEDLVKQIELICIPFFRTISLFNSICLNQSPNANIISLNNFKDFQDFIGLEISIFEILKSPPKSLNEYFTKMNGNFNREIDNKMPITETLTPPIEFTFSTLPKKFSTIWRESEQKTNSQGLPLPNNAGLCLVTGDIVDLDLRSNSLDSSYFNISSHSNNIKAHSVYLCIKGKLSSAVISYHPRFGLILLKQIYRDKWNEIDIGIRRGKDLFLDKSSLLDLRNMFLFQKIIVEATEFKRNRNQRNRMIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVM7</accession>
    <name>A0A9Q0LVM7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVM7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF122">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN SKYWALKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="145"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="350" mass="41825" checksum="4D13F58D002903E8" modified="2023-09-13" version="1">MKYVIEKGTIKFKKIGIELFEMIEKWIKENEQKNNDKINQNIQKEKFNKIIEEFIPKINIKCLKNKTLKQIKKIEFLPNIFLIGIENLRNERIYQKQKLENEKKEKDEIIQKIQKENQEMKPIYEEMKSIYKEKMELNKIFEESKIIKEIEFMKKLKEWIQNEFFNKMKIGFSCQKDGFSSQTFHSKCDNKGKTLIIIQTTDKYIFGGFTEIGFISGSNRYIKDSNAFIFSLKNPKNDIPQKFEIQKGKEGYAICYTKNDGPRFGQYQKNENSNYYFHNYSHNYSHNYSHSEQEKKYDIRIKSDLKSGNTDFGATYSLPNGLKHGTNEAKSYLTGSYKNWKIEEMEIYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVN2</accession>
    <name>A0A9Q0LVN2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase class 3 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVN2"/>
    <dbReference type="OMA" id="EGEMWFE"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023:SF6">
        <property type="entry name" value="LIPASE CLASS 3 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023">
        <property type="entry name" value="LIPASE CLASS 3 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="132"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="565" mass="66032" checksum="0698BBD58A16950F" modified="2023-09-13" version="1">MDKKKKKTFLSNENALVTTAVKTMFQDEVSNWKLTDFSIGMVYFMKRNYRVYQKQKTQMKEEDFFKVCFLPHFIKQLQEYALLADASYEKTLQKLMTATSFDKQQLIVYKFRSSTFRPAYFLAVNDIQKEVYLAIRGTKSMTDCLTDLNGMMCKFSDGFGHNGMVNAALWMEFHLKKKISEIMEQKKNYKLVLIGHSLGGGVASLLTILLSKSFPKIHCYGFGTPSVLDRSLSKKYRHLITTVVHRHDLVPRFSFFGMKKLREKIEDYQWKIEMKGDVLNTKIIRNLKKKANWTHSKLSFLTNNQKVKKISNKLSKPTQKISNVGHKAVESTQKAYKSSKQFTKKIVKSTGGMIKNLKGRLSKKKGKGKEEEKEEEKEKEEEIENQNENQNENENQNQNQNENENQIENQNENENENQNENENQNENQDEIEDEDEDEIEIEKSEISDSSDIDLNIRGLESENEKSEIESNDSENEKEDQEFKLFIEKLSKEERTQRQETSFLQTPGNVLWIENFGDQWFIIPKENEEFEEMKVIKGMINNHLLTSYSEALENSLITVLKMKGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVT7</accession>
    <name>A0A9Q0LVT7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tenascin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000018">
        <property type="protein sequence ID" value="KAJ5079998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVT7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="119"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="562" mass="63116" checksum="63CFEE4186F39C6F" modified="2023-09-13" version="1">MTAIGTYGGNQTFVYKVDFIPQVNIINCSSLFSSFDCYWDKIESPLTLKYQINYGFDWIDIDSPILEDVNVYYQQFNSSIYDNITGNEYYSIQIKACDSNSIKCGESSSLINLTTKIDSVKDFHLSNPSNYSINITWNPPNVQINEGIAHLDHYNISYFIQSQPDLISFISVDNSSISYFLENLECEKDYNISICGCRTQECEGDDKGEVIELPISISFEEVSNISCSISYSLDINCSWNSINNCPIPFYYNFTYQSISQNDSRNYQPTSTNQQFTAQIPNQEYQINISACNSNDKCGDISTISITTDNLPIAPTIYEIISKIEEIEFHFIKLTNANNYSISVDNGTNWQKFTLLEFNGIQVIGIINGLSGNVEYNISIRGCSDLNCETPYLGEPSSINSTKAKLGNITSLNCISLINGFICTWDSLILSSGLKGYSFTYNSTYNSTSICLTNLQSPRYSITELKSEEYYEISIYSSADLNCSNNEYSGINSTTSITTSPPYEPCQKSDNSSNTTAITIGIIVPIIVISTIIIGIILYKNKKRKNPTIQTKEEQELQDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVY4</accession>
    <name>A0A9Q0LVY4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000018">
        <property type="protein sequence ID" value="KAJ5079982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVY4"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="130" mass="15544" checksum="647423E66169B258" modified="2023-09-13" version="1">MRIKNRYQARENPFSHGCCGNWKEVFCSKNPKTNFSFKSFISENELESLKIQVLKPESKCWPEKKLQIIEFYQKYQKTINLKSEILKENLIENDLEKLNENLNENLNEDNDLILDEDNNENLKENDLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVZ2</accession>
    <name>A0A9Q0LVZ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVZ2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="717" mass="81552" checksum="C4FF71BC65B84FF3" modified="2023-09-13" version="1">MKKTIKNNFFAITISITILFILHSTKETFQEIEEMSFPTSSDGASQAFLYEDHFYVTILSDPIYLLKFSKDNFDIADFLNLESDEVWSSVVYKDAVYLGTDGEPGHIIQVNLTTFKKGIDLVMEENENYLDSIAFDGNHTAYFTTVTSPANVIKVDLETFTRVNATQLRNYSLDPVDSESSYGCGIDTVNKFLYASSDNEPTRIWKVDLENFELVDTLEMEANDIYVDGFIIANKKEPEMTDDLMYVSTWTSPMQIIIINLTDFSRVGLVPISLTNNPEESWRVYFDNETYKAYFPSDRGIPLIVVIQANTSKYIETLQYPNIFGVVESMQLEHANNTTYGYAGLMDNGGVARLNLDNQSDFKNTSLPSFNQTTNIVIDEETQFAYITFFLNANYSLIVNFNLSDFSFARYQKYPNDDPVISSSHLDKENNSTYFLVGSYNFQVYILSLIDDSINHTEILSNSSPITSIFDETNHLLYSVIKFTENSSCSILKITTPDFGIIDKFDFYANTCATISAFDKDRNIGYFIGKGSSGKYNLFQIDLTDLSLLRSLELHESAVTSMVFDSLHNSIYFVEYNITNPNRNETGNYTYFESCPLYIVDLNKFEIFGNILLPDMGVVITSFMGITDNYAYFVKHGYDVHVVKFDTISYSISNIIYISSDAEFAFASAIDRSTGFAYIGTVQSPGRFIKIEVTENFSIKQEFCGLIILIMIFLIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW28</accession>
    <name>A0A9Q0LW28_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW28"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="320"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="619"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5079810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="767" mass="90312" checksum="A0122B1A92F53B4C" modified="2023-09-13" version="1">MGSKRKKKNKKKKFKKLKAKKNVSKLKSKLKNKAIKTKTNQKANQKTNQKAKTNININIKPAIILQKKNLKSVKVSQLHQILKFFGDENLQLPEWIQIENKKQISNVIFLFCPGLNYDILTKFEEQLPTITQELKTGLNIFTNSPGTKFSCFPSIIPLLKDNITKKNNSESNQNQKENQNQNEKENQNQNQKENEKEKEKENQNQNQKEKEKEKEKEKENQNENQNENQNEKEKEKEKEKEKENQNEKENQKENETQNKQKEIEELLNKKEYIFDPKFFVLTNEQLDQNDFPNENKNPDFLETLPFSQTIHTKIKSKPFQIFAIDCEMCGTKIGSELTRLTLINENYEKIYDEFILTQNPIIDYRTQFSGITEEVMKKAKKTFEEAQKDIIGLIPKESYLVGHSLENDLKSLRLIHKNSIDTSLLFSHPKVRHYKPSLRYLSETFLYQKIQNNGLLGHDSYVDAVSALKLLQLKLIHGSQFGIVSGNQTQSESVPFPKEEELIFEKISKGYSTFIIDRSSGSERFSLRTQAKQIIVESDDLIPQEFEKIFDLKENENENENQNEIKIENNNEIENEIENENENENENENQNQNENQSESESENENENENENENQNQNENESENENESENENESENENESENENENENENENENEKKENQNEKKFIWIQFHKFRNFHSTHIESLEQPRVQLVLSHILKKFDNQYSQIISKCPSNSLVILYLAEGSIPRVRKLQKERAQNQVKFDLTRFNEFLEFIETTKKGITLFKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWC3</accession>
    <name>A0A9Q0LWC3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NANIHLA"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="9">
        <location>
            <begin position="3011"/>
            <end position="3092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3632"/>
            <end position="3749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1444"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2451"/>
            <end position="2513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="3438"/>
            <end position="3465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5079759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="4054" mass="485068" checksum="8CB8B96D19666EA6" modified="2023-09-13" version="1">MKDIIQSIDNLSIDFNLLEWIYNLQLSETFQNIWNSKIQKLTITINFEDMINPLISECSKEWEKLYIQIKKLEIKFSEIDFILPIQQDKNYLLNEIKFFNSNYQLQKNEENKENEENLKKYIELREQIFHFFSFWKFCENLNFTNYQNIFTNIIQDWGNLKLSKINQIRNNLEEKIMINSNFPLHLFNQLIPIEFTENKSQNYIYQNQKFKEKLFNFLKKQNDDIFYSNIHQDISEDERQKVAIIYLFNLRERIKSYLYEPDSSSFKSFIEQIQKEEENFQKNPKEISFELIHNLLPEIKELIKNRKETTQLNAKKSVNEIFYIELQNNLFQIEKKEEENTIEAIQSFLNSFEIIQKCKELLFKLSSKLHFNYKENYENKIIFGKNENYQNKLEKYRKKLEKDLKKWKLDLKEIFKKYFYLSFFSTNQILVLFQFFKSIFKEKEKEKEKEKEISEILKLYSKNLSINIIKNKLKTIQDFKIQTLADNLNQILKENFDNQRIFILPKEELNYVTYKLIENKLIKRFNQKSGKISNPKIFIHSSKTEYDVYDIVSTIYFIFSHQLPLREQILICDKQTKKDDISNFLKIYELYNSNEFSQEKKEKIINNNNNNPFLFSLVHGNRLPKKKQSFLISKIQSINFETKYPLIIFFSGEGFLSKNLIYSFRSGLIEKGYIEALNNYDIYRKFIEINSFSKQFIVFTSKFAGNGKTFQIRKWCYEQNQNPKTDFKYHNITITSEKKSEIIKKLNDFSNIILNENLKEKIYIHIELPYSSKIEISDYLWTLIMWGSIENKKYLPNNNFAWNISNNVILIFEIPSYRVDEPKKDFILFPTLKYLEEKKCKVKKKFFSFDYYIPTKNGEISKYEDQDLIHVSNLFEFYEQKFKLLEGKTKEKRIEIFNDKSLLHQKKIFKSSSKLILEHFNTGELTFRLLSNFWMVLKYHINLLMGYEYLDPKMAKYLFQTEEKGELFQKQFIDSYFLSVIKLIYRSFDWTKLLDNNLIELKESCEIFKEILPWEKRDLFILILKISTKKNENQEKVENLKYLSGFNPLGTDEKEMINCFDPELQLILKENGFKFNEPLPKYPKRKDYEFLFSLFKSLSLSPSQIEIENLISSHKENNSKYVLTNDNFLKMIFIQYKLLSNLPIILIGETGCGKTSLVEYLCETIMKQKLILFLVNGKTKRKEIYSIIENSEKEIQKEEKFIIIFFDEFNTAPKKCLILMKSLFFDRTLNGKIISPQIKFIAAGNPYRLRNKTKTDEDFLTDEGLIFDYGEKQDEMKLLRQEVYRVHQIPDSFFDDIFDFGNLKKQTEKPYIEKIIQNSINEINSKKSSSIFIDSTKFTKLFTELLAKSFNFLRYHSNDKLSAVSLRDCSKTLKIFNWLLTETNVDFLLPSKNYNQNQNQNQNQNQKINSFIISLFISFGCQFNSDLRLAYFKILYEKFSKFYKKNENENNKNKNKEIEMKNENDILKFIEEIEEKLIKELDINVKEWNVAINQALKENIFLIFFCCYTQIPLFLIGKPELNLPALKPFYIQCSPITKASEINNIFKKAREYSSKFNSEDVISVVILDEVALAEVSPDLPLSILHSELEKVDKKLMKQQNLLIQKDEVFVSIISVSNWKLDPSQTNRGILLKRVDPSIEELSFTAQKILFSFNSKFPKEFANKLAQVYYLISNNQFSNIQEKEKEKEKEKEKKQNPRYYFGLRDFYYFLKMIGLNFSSNLIEYNNSDMIWNAIYRNFGSKPHLIQILQPKIMKILEIDQPKYIPSTFSLIQQNLTFSIVDNNSFPNKKLSDNFLNNPQKFSRHLMILSNDLSILPLIISQIKNNFIVLFGSSFAEDKSRFRIIQNLKKVEYAVSSGQTIILYNNEQLYEPLYDLLNQNYIREGNKLFAHFSFGDINRNILVDPKFRIIVIIDKTRAYDFELEPILNRFEKQIFISEDFIKQDQIKQIIEKQIEILGRIEKATNYQIRKGNLIINYNNDIFPSLAIKLQNELLLNSSENLTKTKDQIEKEARIKWIRICRIDKMFKVIDLVSSGKLRSSNQKLFEDFLTEYKRNFHINLQDLFKKEILKNKIKNSIIFTYSSIIQQNMKLLKGYKILQIDVSNYDSDKDLEKYLKDKWIENMDNENFILKVHFTISVRNSFQMFYQVKYLIENLLLENYDKKQKNNQNDVKENLRRNNSLKDHKSYIMLILHLTPIQKDDLFYYCFENNWEFYYLNELKQEYNFNLIKMKNQNFNLKDIIYNLKENFHQFIQEIKPLSISQISNPLNQKYINEFNQLLDLLLNDKEIINAFFLSLIKIINSGEKEGLELYNWNLQEIFKNYNLINSITSYSFDIFVSKISKIFGLMLNNLNLNQNLKLLNNKEKESKEELIIKRIWITILQEYEIPCYEFFLKDKFQNSKFPFSFYIYSLIEDFGFISKDMEVLNELINLPFCECSLFKEINQNQIQNKNQNQNQNQNQNQIEIEIENENQIENQIENENEIENQNQNQNQNEIENQNQNKKFIENILSRYLNDFLIFAIGKTNLEKFNQIQINLINLIELFNDKKIIRLSLKEIHSTFFQYIRSLLNNIFSIQHYFNSLAILNIKTLKTSQELKKKTFSIFSFLENYFSSLRNILFNEKDNRLKKFVCGIISKSNFEIQNILLSLIKNCKNKNNEKAKKKTKELIENWSKLLILRNIFISLLFPFNEKLRKKQKEIILELFKNYEKNKKQNELNKYITDLFIKFWKEFQPKKKIDKKKYPGSEVIKQLEHRRKVNQTLIRGYCTLYFENVGKILIQQIIFESNLQENEAKENFNQFINILVGKEKKILDIRRLNFIKSNFVMNSLIHFITEPLAFDKISRLVDFRSFSIQNPNQMIIENPKIFENELGINWIVYLCKIIYERKGQKELSQFISQNIQNLQKKIPDIKMDKLASCEFNYKIDIPNIKGISLVEHFQNEMKGINNLKEYESGKYPLMIASISRKKLQDNKITNEIISIIFHTIEFIEAINFEPLKKLISNEMMQKYEESSTINTMKELKEIYWIGMPGHPLLKEYLKGGRAWWKCKNNHVFYIGECAEPDEIGVCPVCNEKIGGTHYSLLNGTTRAKEKDFPSPLGYLHSFYEIEDEQCRSNLKYDCYLILKIITNCVILCFSTINDHFANNFLNNIINPNMKKPKNIQELKEILKVKVEEDFILLAKILNLSIEDVYHFYHHFLNDLGSDNKWKLISSENINEFKDENKRIEIEAFFGYQLQKNKQKILEIVKEKQGIEFKNAIKELNNYKTVYQSITYKRQTYQQFLSFFKEDVNEEIPKSPIILFVIENWKKLYSLSLFPGFLNFTSYVMETLNGKISKKDSENLTIEEFIKNEESKNKDKSNKIEKWYEDFEKFWNLTWKDVKGVFGCREIPNYLQQIEMSKNLPISFCLSGEEDVFICVPSLIKYAISMHNQLMGNKDIQYLFLIKQKKKNIEKKENNHNNNYNQIGTYEEEYRKHPELFRSKKKDNNNHKNNNNNNGFDPIDFIKDNPLKIIKIKIIKIKIIKIKIIKIKIIKINININIKIIKIKINIKININININIKIIKIKIKIIKIIKIIKIIKIIKIKIKITKIKINIKIIKININIKINIKIKIKIKIKIKIKKIKIKIIKIKIKKHKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDNQDKDNQDKHKDKHKDKDKDNKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDNQDKDNHKKKEKKIKEYGKEKKVKRLIDPFEKFTINFPLNYEEFDKSKIIHLNTEEVIDFINDHNIYQISVILLKEYLIDFLNITTKPKWIESKIEYFIFNDNFNQRLLRLNDQRWQQEKIPQQIWKEIIQELEETNAINQCMSLIQIVVFSCSNIPLDSVHLHNIPNLNFLEFAEKNLHLSRNNNLISTKNGSKTIQNLKLKHLVNLHLNFEEYFYEPREKISGKFKKEISEKKKKELNEMIEYFNLPILLSLWKKSLMKIEDCLNEKTKFKKFIIYIDPNDENEKQILDLIPRYFPKSILLKHSLSGYEFLLSKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWD5</accession>
    <name>A0A9Q0LWD5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myb-like protein x</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17063at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF11">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE JMJ25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="889"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1307"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="893"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1241"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1332"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1351"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1390"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1410"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1428"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1452"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1479" mass="172857" checksum="5FF2D520D80271C1" modified="2023-09-13" version="1">MEFQKILQLKNQNITTFHPKKNIIFSIKSKKIYENNMETDIKKVIFEDKSINKINELVSFSQFPFLVGSTKNGGIILFDMEKHTISNEYIPSKKDDKQMITSLFADYSTPTLFYSRESSGILHIHNLIPNQDSIQLQQIDLQVSKKPICQLSASRFQSKIAVLNSDFSVKIWDWKQKSFLCELDFIPINFNLNQGIFQSKKGKSKKIKKKNVKIKPTCIAFSPKEDNNLIVGGTQGFVSIWSTRDPANCQLKACVFLDNSITIKSISFHSFLNEFFVLASNGRVISLRYFPNDSQLKISDQFLTYCGKSTTKSVFFQKMQSHQSCNYISLVETNSQMEIEGTAIYSVCDKLYPSTFMPIATQMEIPDLNSSSIFTPENNNEQNQIQICNKIFYMDFNNVKTSGENCIKQYTLPRNKTKKEKQKEKEKEKEKIKMKYKIPDIIQEEISKGARVIKFIYNSKSKIFLILIQLKVDLVRETTNYCHKVALESNQRVIIFYLIDKNGKIIDNERYPLYLKGYKISKIFPTPLKQNRVLLYQILSERKLVYSRNLLSLLLNDSLEFQLVDFEPENVAQPQVNEPKTLPKESPTKKSTQEKKALGDDLLGIDMGGFLSNSLINPIFPTNNITNTLLQPKKSGGNLEKSKFFQLEHKENVYEIKWNKTQPENAKELFFAAIITNLRIAIINTEFEIIHTVWNPFIHDCMYFHSCFWVGYSLFFNTKHNLNFLTFDSSSSPKTISTLNYDKSRISAVLFDRILYSIMDYTLINNEDWVIISEQGIDLTESLIMGLVSFENFLRKTTNSQSQLSPSKEFKQKIYQIISRIKTPRISTDLADFLFQNKFFKASSMLFNIFRNLESNQSENQNEDQVTPQKSSNQNEILKETISKININRNRYQKNESNPDDKLRSKQKKPTKEQVLEEILFELLTTNKEILANLEEKEVSIALQKIIDQNLMENENQLSNFNKSNQNFNKKNDTQNQQNHPDMKTFLEFNSKIPKYKVPFDQINSYSDEVQIKTNQIRKEILKKIGIECLKCGQFEFAEICFKESGEYFGLFFIYTLFGNNYGIAQLIYQLFQENNQNQNQNQNQNQNLLIQYLSAFSNWMKISEEILNPTKKIDEVKAILESHFDLDLSKEQEKNQLAKFRFIIQNEEEKYLEPEKKFEIRIENIFKVSELDLEDLKNWFTIPFTHEKSDFIEEEQYQQQEMQVNEFPKNQIPQQETQKPISPSNLENQPKNDLNNPQENEQKEQKKEPEEPQKLADIDIGKATTEQLATIINRAWDNNETSDSEFETDPEEKRIFAGLSTLVIKKKDEVEKKDKPTRSGFKISLNKKGGLIKEKERVEITEVVSNPQIKKKDDEKSQNDQESQKGKSIELKKPNLIKPKTGNSNTQTKENNSIQNNNNDDNNNNKDDNDFDFYDEINFESISNPNLKEKEKEKEKENQKEKENQIEKNEKKRKSKRKSKRKSKSKRKRKRKRKRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWE6</accession>
    <name>A0A9Q0LWE6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fasciclin-2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040226620" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1729"/>
            <end position="1751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1762" mass="199101" checksum="52C27850180D40E7" modified="2023-09-13" version="1">MKKLLFFFGFFFFISFIKSELTLNQELYFPEGIEYPTYSFIDASNQLVYFADDPWGMDEYVLEGKLYKFNMSTLDLIDSLDLGIWGVGSGVFDTENNLAYFGSDSSPSQISKVDLNTFQVVGVLTLGTYYGFESAQIDIENQKAYFVSYYPAQVIKIDLNTFQQEGDPLELNYEYGFGSVIDLENNILYVSGENDYNYYSLIFKINLTDFTIIADLDLTEYDVYRASQGFLGVSKEFLYFGNYDYPFLVVKIDVETFSYDDALELEDYEWCVAAAIDENENTGYFVTEDPAIVRVDLDSFSFIDGEYLDGYSYSSTASFDFQYNYSFISLAYAEIIKFDLTKFQQEIEFLEPLFIQVQYILLDEPNQTIYLLFENYEYIIISKVDIESFQMIDYVILDYYDDIYAGDIDIQNGFLYYFIDDSGILVLKVDMFNLTNMEYVDIDSSGYVDDAVYDPNNNLLYLAYFDDDEVLLFLTLSCPDLEILDSIYIGDAEFYYFRFDYSTGYIYSYFEYWETEEEGDYIIKISTPDLNITDFINITSYDISTMSLDQANQRMYFGTRTGRYRKNQEEKLEDSMFSEICSIDLNYMEMISCQEVSGVYDFTDSFIDGDGNFGFFFTEFEDDFEELITAVIQLDLIQNTIELDVLDEYFDYPFGIFDPTTNFYYLTAWGNYPVPLAQFSIEEPLVPNVYLFGCNSLFSKFECYWFQIENDEQLQYQINYGFNWTIIEDPVLIDGFDVRYQEFNSSFYPNITGNEYYSIQIRACNLTLNECGKPSSIYDLITRIDSVKNYDLDGYYDYIDIFWDYPDVEIIEGIPNLDHYEVSIQKETDLPSNFSINDSSATYIKVDELEFGYTYYVSMWACSTEECEDEEKGEVVSSSISTGFPNVNSFDCVVSDVLVIDCSWLKPSTSGTPSYYTFTYVATTKEDSDTYYPNSTNQSFRANFQVEEYKINVSGCNSNDFCGLISTVNVTTERLQPPIIKQSISQIEEIKLIFTELTQGRGYLISSNNGTNWQNFTTLYSNETDMIGTLSPLSGNYEYLISIRGCTDSSCGIDYLGLPTSPISISPKLGNVMITCVPLLYGFYCDWEPLDLSIGLRGYSLSFNSTSKCLSIFETSYSKTELFGGANYEISIFASADSNCSYNEYSGNNTTLSITTSRLPPPLINQSISKIEEIEIIFTPQYQEKIKDYLVSINNEIDWQKFTTIQSNGNEMIGTIKPIAGNVEYIVSIKTCTDPNCESEYLGLASSPISITPKLGNISSFNCNSTICGFECNWESLELSTGLKGYSLSFNSTSICLSPSTTSYSKTELFGGANYEISIFASADLNCNYNEYSGLTSTLSLTTLPLSPPTINQSISKIEEIEIIFTKLTLAKTYLVSINNGIDWQKFTTIQSNGNEMIGTIKPLAGNVEYLVSILGCTDKNCESGYLGLASSPISITPKLGNISSFNCNPISCGFECNWESLELSTGLKGYSLSFNSTPICLSPSTTNYPFDSLIGKANYEISIFASADSNCNYNEYSGLNSTLSLTTLPLSAPTINQSISKIEEIEIIFTKLTQAKTYLVSINNRINWQNFTTIQSNGNEMIGTIKPIAGNVEYLVSIRGCTDSSCETQSLGLASSPISITPKLGNMSSINCNSTICGFECNWEALELSTGLKGYSLSYNSINVCLSAAMTSYSVFNLLGDTYYQISIFASADWRCEESNLSGLPIYTSVTTLPAPVETASDSSKDKVISLSVVVPVVVIALIVVLIILIRKSKKNKKENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWZ0</accession>
    <name>A0A9Q0LWZ0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWZ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="467"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="584" mass="68113" checksum="71CDD51EED56B97C" modified="2023-09-13" version="1">MNDCLFFGRNKNSKLIKNELKIITKPIQFKFKIKNENENENEKQIKQISSTIFSTIFLFKNGKAIEYLNKKPEKIQIKNIQKVTVGAENEAILTIEGNVFAKGNNINPKNSKEFINISSLIEDKNDRIIEDIVAGNTSIYLLTSNQNVYGIGSNYSGQLGFDSKTLPKTEKPILMMKNVSKIFSGNTSSFFFLLNSNQELFGCGDNFWSQLGLGESRKESKIQKLTKIQNIPKGKIIDIQSGYEHSIMLIEIENDDENKNPKRKFYSSGFALYNGLGRNENIYEFTEIKSSLFEENDDILDFSVGIAHTLILTSNKKMIGFGNNFNGQLGNGYTEDEPTPIQIELPKLRFNENISNYHIYCGENKSFIYYSPPSSFSNLEEDLIKLFEKKRILLNQNENQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQMLEYWIYSNQIKDEIEITQEIINEIKRGIDYFQLNQTNPNLFDLLIRKFNYQNQNQKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXD7</accession>
    <name>A0A9Q0LXD7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXD7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="291" mass="35166" checksum="1B708FA8D6CF5D0E" modified="2023-09-13" version="1">MEKNYQGNHSLEDNIPYYLQKFCQLIFDVEPDLLKISLHQKEFIETLSTKEKELLKQIKLLDKLGIIKYELTENENLESAITHHDELYQLLETLEEIIDQSFVYIEDNLFEDANILLSTLVQVADQSFDEAVYSDNEIKRYFFYFHESEDLYFNEYKKLIVSENNEKFREKVDHLLEIYESSVDLEKNIIPENKTQELQKIKEEIKKLLEIMKEQIIQFEQKVEFNFQQLETFLNIRKELDYENISKAKDYSDEKNTQDPKKIKFMIQEKQEKKQKQEQKATKRIAKKERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYA3</accession>
    <name>A0A9Q0LYA3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYA3"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="464" mass="54385" checksum="1C2B8A808F62C1C5" modified="2023-09-13" version="1">MNEELLNKQFPQFELFRLEKILTISPLKSAQKTKAKRKFVSIVTQEYNKQYSLLATATSTGNITIRCSTPTQFLWIRHIKWSPIRSISKEIILIELAPEAEYLLVISSDSAVIVIPLILTLQKMLSHDELCQIEKDAQVNNPKNNKKFDSKEEKKNSLRKKYVPKFNNRQILCIKTLVKKIRKSENITDCIWWRSGLIESKKFSNSNQNQNQNQNQNQNQNQNENQNENQNQNENENQNQNQNQNQNQNQIQNQNQNQNQNQNQNQNQNQNQNQNQNQNNKNNKKNQNNKNNKNKNEDQEINDYAILSTTKGNIYFLDLSSLNDNLIQIQDPIKEMKLISCEDRSFLIITTYQGKINRLVLEDFDENNHYRSVITHYGTPPLALMKTNKISQGSRISVQYSENRKFLSIYDPKDSKLEIYEPEFPTNPLFTYDIASIAMHLVLTDNFLLLLQEMNKKEHSIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4E7</accession>
    <name>A0A9Q0R4E7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Early girl isoform a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_03148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4E7"/>
    <dbReference type="OrthoDB" id="438726at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="347" mass="40368" checksum="CE4BA8D86F2C4687" modified="2023-09-13" version="1">MTSFEYFETVSQSLICPICKQPFIDPVQTLCNHKFCRGCILNKNTFNNQCLTCGNYITEDSLSPLLFLKLSCDNLQVYCLNRSRGCQAIIKRNQMENHIKNECKFTKIITPFLQEKKEDPFKLIPNQPQNLPQTITQFPTITNPFDEKPPSYLINFFEQTNFKIDQLSQQIEKLTEKYNTLSTNQIEKGNQTIQSSTLKKIPILIFTKYAKCKHCHVSTKNEWPQCGGCFSSQPRTEFCYINPSTVQSCYQSYPKNIDRQTFILIQCPNCKEIQFPLSLGTLIPSNSTLINRKNNHPFLFWYDTFSHSKQDCDLKQTNVRELHVVISKEEANYLLETFKATFPFTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4F9</accession>
    <name>A0A9Q0R4F9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dopey-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="QHEAITI"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1445"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1776"/>
            <end position="1803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1830" mass="215980" checksum="50A1EF693E06130A" modified="2023-09-13" version="1">MTTFLSSTEKDFSKQIQKVLELFHKSKEWGDLIRNLHQLSKVLQSYNKIKAIPHKFLVAKQLSLCLNNDLPWGVHLKTIEIYAQIFQHIGHEILLKDFPVYSVGLFPAFQYSSNQVRLSILKLLERFVIPFGKQLDSILKGLIVAVLPGLEEEDAEISQRTLLFLQEIEQKADFQLFYVHLFKTMISNPKQTQNIINYLNFKFDLKSNNPKKQNFSIILENEFLNKILVESFVPFFKNEDILVLRKILDFITNQIPLRSKYLTREQKAQLLESCFKIFPRKDSTLKHRIFLWLDLENQKEIEEIQQLILSSFLRLFEENEQQNLKKMDLVIISESMENEKLLQLLSKKIIHLSINQFAKKENQIDGITIPKFNQEDVLEFLNSLVEQSLKEMSQEYPSKFFHEILSKITTLISEDGKLLKLNDETKLQIAQIFLYNLNRVQFQKSQEIESNSFVFTKESISHSFFINYCLFIKMFHQFIFHENGKIANSPKIIDSMLLLLEKTLIDLSSIAFDQHKIYLSQKFKESMAIVNDFAKQFFCLDFIWEKPSGGIEEFVQKILQKIHQFSQKPDIFQTDILFLFFIQIVKILLHLKNQAKSSKLINKFIKEFGQNGDLKQDEMEKPNEFIRNRNLLGKHFLSFSEFIIALSKKLFENLFVNKDTILKNEIVLLLNEIEELFPAEFAKIISDELTNIAEPIQGLVRYTAFWGFSESVSQDYFPSNECFHLFMSHIHASQNPFQVSFIENWISKTISNSKINKILDPIIMELFSLLMIYYSEGISNENPNLENTNHFSLLRIKDLILKQAEIRTNFNTKFIQHYQNFPDQGSYFEMLLIISSLFSVACLESGTETENEKQSNSFNNENNLIKIQTLQVMNNLLLMFQKNMQEFVQFSELFLKRLMIIVQELFHEIGASIQKADSMHQMHLLQTLSLSISILAKINQFEEVANSFSKFLHCDEFVSTIIAGLSQNPTEESSHSKYYYYYYSIGIPDQFVTYFSDIRLKWIDFVIDLSENIEPKEFLILSDIIKNICIQIQSKNQIVMSVFEMKNSRNLIEDQTLLHREMNYIQFLISGIHKIITTNKFQWTDSLANIAKSKNQDSKTENQDQEKKKESNFLISAPFSMISGLVSQIISTTSNESLSAAEKRQIIISWQLAFIINSIITFWDFTDHIKDLMENNQNNQNNNNNNNEDPFDLQMIYSLINDPIFQKITNQVGNELANLFLYLNKDFSEELLFSVLIVWNSWIGSENLRTKLFLLNHKELFHKQKALISIIIKTQVLPPAFLYQKFVSVLNVFQYEFNDVVMGQYPKFDVGNVQDDSRKEIGNTKQMQKDVTIYLKFTSSYYFLEIYFQYLIKFRKGINLNQELLQFLKEIVKMTQIPTTLFILFRAFKKLIRSLSNLPDDKKLCEDLRDFTKQLLTICFYYTSDSFQLKETQIKPIYFVHKNHFHKIQRENQEKKNEMNNLEKENNAKIENKKMTKEEKRIQLIQIQHLIHQHLKSLGLRSLSRSGEILHLVFTQESQIISILNSLNVPKNHFPYIIRNEAYFSQEILKILSHLSKYPEMLNVWKKNIWEIFMSEGFFPIKSQTITYWKEIVISLIKGDESLIDELLQNQVNTGVLSFVGNLVRKDRENEEVLLKIKILQRLAFIVLSSSFNQLSFKIEQIKQFLIDCLKLKSSSNLIKLIFLILQILIYKMDYLKISTMWQIILPEMMKIFSQNIVNQEIVFSGLKLLDFVLLLIPEHFQIFDWIFFFEKESQKHLFNQEIEFIPYFTKFGLGLKNEEKRNENENKNKNKNKKEEQKFNNQNQFKNQLLQIFKFKILMKQKKLYLHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4R7</accession>
    <name>A0A9Q0R4R7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000142">
        <property type="protein sequence ID" value="KAJ5066478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4R7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="497"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="602" mass="70365" checksum="7F615619007C7454" modified="2023-09-13" version="1">MNDCLFFGENNKPILIKNKSNKITKPIQFKFENENENEKQIKQISSTEFSTIFLFENGKAIEYLNERYINEDDEDEDENDSNQNPQKIQIEENIQKVTVGGNHEAILTIEGNLFAKGKDITSKNPKKFINISSLIEDKNDRIIQDIVSGWQSIYLLTSNQNVYGIGDNYDGQIGFYSITFDKEEKPILMMKNVSKIFSGNCSTSVFLLNSNQELFGCGDNAFGQLGLGESRKEETTIHKLTKIQNIPKGKIIDIQTGNYHSMMLIENENQNQNPKRKLYSCGDFDYNGFGKFENEFTEIKSSLFENDNILDFSVTYKHSLILTSNPKLIVFGLNDYGQLGTGYTNNQLTPIQIELPKLRFNENISNYHVLCGSFCKSFLYYSPPSFSNLEEDLIKLFERKEFCNISFKTRNGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPILYFEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIDELETGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5W9</accession>
    <name>A0A9Q0R5W9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5W9"/>
    <dbReference type="OMA" id="CELKERQ"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="586" mass="66967" checksum="922CFBB314ACC47D" modified="2023-09-13" version="1">MENKEIINFLLNEKYKFSSSYISQRKKLLLNKLSSGNFDIEFRKKQYYSLRNILLSEKKKKKQKIIKQKKSKISPNKESKSPFGARNVPQKTEINRIEEYLEQNQEIEKLSFFGLEKETKTEKTDSNLDLIAEPREKKETTEEAYSFSGIHQLFDHNKDAITCLKFAHQNSDLLAFASLDGTLSIVASYLNPRVLGVLKGHTSGISDLDWSYSNEYIITTSYDKTIRCWSVSTMKCIRTIQDKTESLCIKFHPLNNNLFVVGFADSCLKMYNFSTGNLELKFDISSRRAAISTRKGSVKNIFEKDRQRKSSRHNQTNKNSPRVADKNPQIRPYFLISSNQKSSITSICFDKSGSFIFAGTSKGVLFTFRIDGINTFNAVQDAVMVSSFKLRRNKIRIKKTFKYTLPNEVAISSLQFSAPRVSRGYPVILANCLDDMIRIFQVDFASKKPGALTLFNSLSVKMQFYTCRSIFCPLVSTRKDVCIVSGSEDHSIYIFDITRHQKPVINNLQAHETPVIVADFSFDEALLASGDASGTVIIWKRKPIVSVDEKQKNNLNTKVSDSDSFSESSENFENFDYLRDAILNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R691</accession>
    <name>A0A9Q0R691_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5068023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R691"/>
    <dbReference type="OrthoDB" id="2289278at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31334:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE PROTEIN SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31334">
        <property type="entry name" value="SMITH-MAGENIS SYNDROME REGION GENE 8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5068023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="685" mass="80599" checksum="5149A1B50F42FFDA" modified="2023-09-13" version="1">MIETEAIEIKKQKQEQEDSESELTISYSSSPTEIINELPKPLFGLISTKTEFIESRIDFTKKKKKTKENYIEGVPSDFIVLSEFCEQQGPVDVFVYPPWIKHTYNIATLVLKTMSTDYQRSKPNMLISEDSQFVITLAQNAYAYAHHFTLYDANARGYVRPACFTYVSNRQDKLMRNFASLIHEFSKLINQLKAHNQLLFFKEIQIRLFDLENSIEQVLINEKQNKKAEISSDENGSRYLLSIPNTSFERMLNDTSFLKNQIYNSLCNLFFVENILDIYPHPNSNKQKGIKYKYQEENFIPKGYKAKYVSHHHKTVTLDRKLRHFREICIPEVFEACLENVKTIHNLFKQNEYQKTLRDYFSELAILEESFFIIGAKSHLSFSLSPRESIHIDDDEDIDDDIQIIQNTQDNETKIEKGLENFFKSLFSKKIRTKNTFKTHNFYEFLWDTEHTNYFGKGILVISKKYSWCLDHLIFSLLTGRPLIIIGNQKNQYDIYLIVQCFSLFVPGYLTPKTIISWKKNIEFNDLHELRLCGFPSNVLIPDKIRRFCSILDTENEILQAPFYHSFDPKNSFIAKLIDTNKSWIDESVLLAFIQQKLLEISIQTFLCFHLKQNPKVIFPEISFDDEKILFYLINLMDHQLITSIKENNSYNNSVHFNLDLRPCQFIIKNNSAQDKIDSKKKRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R748</accession>
    <name>A0A9Q0R748_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R748"/>
    <dbReference type="OMA" id="CIAWFRE"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="59"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="252" mass="29452" checksum="3BB0117B4A85827C" modified="2023-09-13" version="1">MDSLSRRQKSKVRRMISEAHVSESEAIRLLKANNWNHAKALQESQSSTSSIIPKPPVTPQYSKLDDLFDQYKNKETGKIDPMGIQSFFRDIDVDIMDILSLIVCWKINARSLAEIPRDVFVQGWKNLGCDSIDSMKKQMPAFRKSIENEQNFEKFYQFLFDFAKENPDYRFLKVPEASALWSVILQSRFDLLDDWLEFLEKNPKLTITKDAWNLLLDFSKTVSKDLSNYDETAAWPSIIDDFVEYVQEKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8M8</accession>
    <name>A0A9Q0R8M8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho gtpase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8M8"/>
    <dbReference type="OMA" id="FICTHEF"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="4">
        <location>
            <begin position="454"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="617"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="807" mass="95286" checksum="54C4BFC400435759" modified="2023-09-13" version="1">METEIWYELYDLQYQQEYYHSPIYQRTQWERPTEASKILSVAEELRKGDKEAAIKKLEELVNTIKRKETVKYFIKQLQKQEELKKQEQLQKQEELKKQEELKKQEEKIKEEELQKQEQLRLQELQKQEELKKQEELKKQEELKKQEELKKQEQLRLQELQKQEEELKKQEQLRLQELQKQEELQKQEQLRLQELQQEDERQEQLRLQALQQEDERQEQLRLEELQKENEQKIQRKSPQNLRGIPPPINIPKAPRGRSPKRISPSRSLPNQRGARNVSPRGRKPISIKDKQAMFEQKSRAQTPKEESIKKPFDFQQMKNKFGAQNPPVNENQNTPSLQRNQDKDQRRKTLPPRSNKLAALQSKLSMTSQIQVSIPQPSRTAEDVDVVHNALEKTTVKNPQDDDTQDNQKPKKLNDKLNKDIQRFQLSGFAEKHFKKRKNGIIFKREVPVKKLLSYSKNPIKTSLLRLPTVEDCRLAVDAFRNVLIYCGERTSRFSNPIIALTQNLQFGIRSPQLRDELYIQICKQTNDNSNSASLKKAWQIFSLYSQTFPPTRDFENYLTSFLLQELEKKDQNVCAHAKYTLRKLKFICTHEFKTDMPGANIIENIANEPFKPFVFGVTLSECMVHQKKDFPSLQIPRVLNLFVEKIIAKNGATTRGILRPSRSTETAESIKEKIDQGDYTIDEDDPATYVTLLKMWLNELEEPLIPYEEYENFIDCATNFSKLNKMIKKLPQLNRLVLAYLTSLFQEFAKEKNSTLSRLDPDQIGAFFGPVILRSKASVIRDYYQERTIRFIVTLISQWNVSKILNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8S2</accession>
    <name>A0A9Q0R8S2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MITOCHONDRIAL 28S ribosomal protein S29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8S2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="786" mass="94050" checksum="838D08AFF91125A5" modified="2023-09-13" version="1">MSKSNQKEKPKRIVTKEEMEKELEEIPLDLHTKPENVNKIGGIPSNIFDWEESNINFEKQGKLSAILIRKQTQNLIKKIKKGISRKQVLYGSNGAGKSYTLYHIAAYFSQFHVSKVFSQINYLINQTYKKTFTNFSFYFYFYFSFDFDGNDKPNWKKQEKIKRNQNSKSNSKNHTNEMDEKKLIHSNQDRFHQFQVDEKENINLISDQKEEKQKRTKTYGKKQEKWVVLYLNDLNSLINESSFYVAKRIMEDLFHRYGKKLFQTCKFDFEEDLFFSTKFTTEMKEEIIESCRNFLQNLFYLKTHKFRILIAIDEFNILYREKFDINHILNVFRYFPSIRNGMLLVALSSSFDHHKIPDLNLLLYGTEIRFYNKFEFNSICKWKQKERKLPQKNSIKTFQKFTNQVPQMLDIVSLTYQNWKDYDQTTNDFTYQCVSNSIDFYQTRIEYFLEKIFQNKNDSSFYQQIIFPTLVYLNHNLNVLPPIWEKSGLFYHILLPDENNRNQKNFENKKATHAHLNANFRKFQKKKKILPICEFVKEAIIQIFQLQEINFIRTLCSLNIRGWAFELFVLNLFHSQINSQITLDNFDLKGNKGIPKSFEIKIKNFIHQEREKPLKKIEVGDFIVCFGNHWVIDFVCLSKNQEDEKELFYIQVSVQKYNQHSKKVDDLFSLSEFSIQEKKVSLLEYYSNLAGMKFDSEKINLLSNQEKNEENQEKNEFKEKSQENQFVLPQNQYYVYITAENYWETTSQFSFDPVILVNANSLSLLKPSFSLDQIKDFFISKSKQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8W9</accession>
    <name>A0A9Q0R8W9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8W9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="275"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="496"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="70133" checksum="D6AA56FEE80C1235" modified="2023-09-13" version="1">MNEIIFFGLNEYPILIKNESNKIKKPIQLKFENENENENENEIENENENEKQIKQILANKYSTIFLFKNGKAIEYLDENDLNQNPSKIQIKENIQKVTVGVQNVAILTIEGNVFAKGEDINPKNPKEFINISSLIEDINDRIIEDIVSGWDSIYLLTPNQNVYGIGSNDFGQLGFDSFFQKETEKPILMMKNVSKIFSGNSSSHVFLLNSNQELFGCGYNYDGQLGLGESRKEIKIMKLTKIQNIPKGKIIDIQCGFNHSIMLIENQNQNENPKRKLYSCGYYLYNGLGQNGRIDEFTEIKLSLFDDDNILEISVGHAHTLILTSNLKLIGFGNNQYDQLGIGDTEYQLIPIQIELPELRFNENISNYHISCGYRKSFLYSSPSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEVHKLILKYRLNQNQNQNEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNQIKDGIQITQEIINEIETGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R950</accession>
    <name>A0A9Q0R950_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding (Rrm/rbd/rnp motif) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R950"/>
    <dbReference type="OMA" id="QFTNKFQ"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="985" mass="119110" checksum="A4CCC5CEF849E35F" modified="2023-09-13" version="1">MANKCPLCDTKFDNNEKYFYPCSVCKFQVCLLCLEDLKNGSYSCPGCRKKYDDEHIKKAKEEMRKQKKKQEAQLTKKKQQQIKSRNKKNKKNEENEKLIQKKKQEELFEKLQEKKVHRNDLVYLKGVPLNIAKDNLKFKQFLGKFGKVIRMNFTKRVFHRLEKRFLDYPYNKVPSNISPQLLSIDIYVTFETVSQAQNCIKNIQNTKMGEKIFKVDIGTTKYCRQFLSDEKCTKELCEFAHEFEHEDQELFISVFPNSNIAKQIQQNKLKKLNNPNKETNQGNNKNKNQNQNQNQNQNQNQNQNQNQNQNENENQNQNQNQNKNENENKNQNKNENQNQNQNQNENENENQNKNQNQNQNKKKKKNKQVNNQRNQSPQKISNSPNKLTQNNTKKLKQKQENERKTPKNEQEKNPNRLEEKNPNRLEEKNPNRLEEKNPNRLEEKNPNKSEEKKEKLHSKNKTRENISENKRFSRRNEGFINRGEYPEYFQHQQIPPYNNYPPQKGFYDRYQGYSYYSVYDQYSYPNQPKHKKPDRKSKKGSKKELNKESNKESKQESKEESNKESNKESKKESNKESKKESKQESKQESNKHLHKSIHKYSHKNPVLYPNPNPNYYPNPNYYPNPYYNPYYNPNYNPNYNPNYNYLNKYSRHSHHSHNRNRNQNQNSHYSHYSHDPHYPNQYSLQKSHFNKFSRHSRQNQNQNQNQDEDEDENENENQDEDQNQNQDENQYENQDEDENENQYEDENQYENQDEDQNQNQYENQNQYENQDEDENQDEDEDEDENEDEDQNQNEDEDENEDENENENQYEDEDEDEDQNENENENGNGNGNGNQFTNKFQHQNQFTNKLQPPNQFTNKFQPQNQFQLPNQLQFPFQYKNNYNIGEEKKTTTLEEIEEYNSKNSQKNIPKFYNFQNTFNYRNNFESNRKITTLNYPENFKIVNHSQNPLHLSEFNQSFFEPQERNMIFQRNILKKEDDKKKNSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9L6</accession>
    <name>A0A9Q0R9L6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaphase-promoting complex subunit cdc26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9L6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="107" mass="12939" checksum="2B32FC6FA556E824" modified="2023-09-13" version="1">MIRREPTRIILQQEDIYEYDESRNEILQKFAKNQKKKLQTKNENLNENLNENLNENQNENQNENLESNISMNIEKQIINPKEKAEKRKERIGLKKKTQIKTNKLNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB98</accession>
    <name>A0A9Q0RB98_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB98"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="266"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="388"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="527" mass="61430" checksum="C017F17436034DF0" modified="2023-09-13" version="1">MSFDFSDTINISNPIPPPSFPSQFGDLPEIPNDLPQIPNELPQIPNDLPQIPNELSQIPNELSQIPNELEDENQDENQDELEDEIQDELEDEIPNELSQIPNELPPPFPQENQKPKKLPPPLPKEKPKNFPLPNQEPNQESNQELNQELNQELNQELNQELNQELNQESNQESKENQKPNKLPPPLPKEKPKNFPIPNQESNQESNQELNQELNQESNQESNQELNQELNQKEKKKEKKKENKKEKKKEKKKDIEQDSNSNSNDPHTMAAVFLKRGNSKVRDKWRNRYFVVKGGLILYYDKKSSKTPLGVIPLVEIKTVRIVNYGEDGYKENCFSIVVPTRSYWLVAENYEMMKEWVSTLNTLVYRKTKEFQQSKRLENVSQVNKKEGSDYSGWLRQKNNAKSRKKWNKKFCVVSGHSLKIFSTQKYQSKTPSTTYLLWESKSIYVAESETQTPFSFGIEIKDKTHYFAAENESLMNEWINVLKQQAISMPRLKLKKGGKTSNLYQGRSQNNLIQAVRKERKQLQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBH9</accession>
    <name>A0A9Q0RBH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBH9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040406524" evidence="2">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="190" mass="21503" checksum="22381BED29DF5E10" modified="2023-09-13" version="1">MKHSHIIIVLFAILLILSADALALASLITQGLFYIKDKAGIYSNFNFGDFFSDCSGPNCTKTKEALCDWSADVNFFKSTIGNGLLSVASFFLFLNSLFLLKSTPDFSFFLALFGSIFIISGYGSFKIYFKDSDEYSWLEFASNSHLITWDFGSNLPIQVLSFVLGILGSVFILMIWRRKVKKSNQRYFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBZ7</accession>
    <name>A0A9Q0RBZ7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBZ7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26550" checksum="1FC4D75A0218FA1D" modified="2023-09-13" version="1">MNDCLFFGENNLGCFKNKPNKITKPIPIPIQFENENENENENENEKQIKQISSSFFSTIFLFKNGKAIEYLNEKYSKQKPQKIQIEENIQKVKTNFDNIAILTIEGNVFAKGEDINPKNPYKFINISSLIEDTNDRIIEDIVSGYQTIYLLTSNQNAYGIGSNYYSQLGFDSKTLPKTEKPILMMKNVSKIFSGICSNHVFLLNSNQELFGCGDNQNGQVGLGESRKKQKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCT8</accession>
    <name>A0A9Q0RCT8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NIRIFEC"/>
    <dbReference type="OrthoDB" id="5956805at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="833"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1292" mass="147068" checksum="09C869552649184A" modified="2023-09-13" version="1">MLIGWEVKIFQIVVLIQTQIAVQLKYAIEKRINDNDILFIYEGNYYSNSCNITSFDISFQIQAENVTLDCENILPAFLFDFSNNTDNGNITIKGLTIKNADNSNQESIIFSGAGITVNKGKVWIESCSFLNSFSNGSETFPCSAGIYLDSPRYLSINNSNFSNLYNTNATASAIFILNQENLTEPQTFIMESCTFNENYVENQGSTIISVSNENEVLYDYIFTNNTFENNFADYSGGIYFEIFPQENSSIIITNNTFFNNTGQQDGNNFTQNIGIYESSSIRFNPNAIKDWNLGSFEFVNNLIFEDNGYESNIDLSFGFNFTKFDLIIENNNFTSNIVSIAAPIIIATHLIDNQANFSFISNNFVNNTGINSTSGGISIYDEFALNGSQKYFFINNTFINNTGQRSAGGIMLLHPKILGGSYTLFENNTFENNIGPIGGLFYYSYDDSYNNTFEFVGNTFRNNIGNIYSGAIYFVLPKWFFDFNCTFTNNIFEKNTGWRDAGAISFEFSNYSDGINIGLFGNTFINNSGGQGGDLSIRNDLTKTQNFNGIFEDNIFEMSSSNGGGSLFFDTLSTLSIQNCEFINNYAIEGGSIFITGQTELTINNTKFSQNNGMFGSTILSFSREKTTIINSILDTPNDSGKIGYFENIEPILENTTITCGEGYIYQNSTSTKYKNDIEVISYFYECVPCPQGSYSMNYGGNFEGAMNFCFKCPYGATCNGINKITPLSGFWGFPTNSSQFLEYKPCPTGYCTIKTSETESILSGDYNYCSGNRKGILCGECEEGYTNTLSDESECVLKEDCQGGLGYYLFLALIKAVIYSLILLFKPQDGSGSFIVVVYFFQMITYVLPQIRKDPDEKDQGSQQFASILQFISDLVNLKASFPTLKTWGNCPNDHISSVEKIAYNLVGPAFYFGVLLLFVLIYYLIVYLKKKRKQKKQRKKEKEEKEKEKEESLKLEDLNNKQNQQINNENQDNNENEMNENQENENENENNNENENNENEMNENNNENENNQNQNNQNQNNNENEMNENDNDNENKIFDSKETKFTQKQIIFDAFLTLFILTYTNLSETTLNLLNCIPIKFEDGHTEKRLYFSGNVKCYNSWQIFLFFIVILIGLFPFLILIWKRWAKKKYSEKLKKKKSPYVEVMIFILEAPFVKNCKYWRSFYLFRRFAIIVIFVFVIDPFIKSFIISMICLIILLLTIILSPFHNKRVMKMEYLSLSVLVIFSIMTMRDGSLASAGVDNELGSLKDTTLAFNVIGYILTITVLLFALINFFIGFRSQIKSYCSKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD79</accession>
    <name>A0A9Q0RD79_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD79"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="93" mass="11238" checksum="7FA1A23EA16EDEFC" modified="2023-09-13" version="1">MRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKEIINEIKKGIDYFQLNQTNPNLFDLLINKFNNQNQKKNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDN9</accession>
    <name>A0A9Q0RDN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDN9"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="303"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="491" mass="58095" checksum="E7BD17D821917F5D" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFQNQNQNENEKEEESYFDFEIICEQNKISFKTHKSILSSRSQYFKYLFKSKMKEYQENKMILKDFSSSILSSILNYLYSGKIEFNSENAIQILLFSSKYLIDELIETSSDFIKNNFQFENIVDILKLSESMNLNQLLDSSYRFISENFEKFIKTPFFLELEENHLNSILSSNYNLTNEFGIFQSIIKWGKHKSNINQKKENEKLEKEEKEKLQDQISNIIQKIRFIDFSKKELEKILKEDLIPNQISRKLMKLLALKTKKDKKGIKKFIKKQHSFIFKSRFHFESKIIKKVEHFNKLKKWINDDSIFSDMELGFSAKEDGFDCENWHDICDDKGKTLVIIKTKDNFIFGGFTKVGFTTDKSKWNYEDEKSNCGFIFDRDAFLFSLRNDKNNRKSEKFPIKKYPQNLAITYYPNSGPNFGDGDFGLNPNLKSGYSNFGRTYNLPNGIKHDTIEANSYLAGSYDQWEVDELETFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RED4</accession>
    <name>A0A9Q0RED4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RED4"/>
    <dbReference type="OMA" id="FNPIVRN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="165" mass="19913" checksum="569DB19FA7DB4C37" modified="2023-09-13" version="1">MQSNSNQEIENKQENNKIIIQNEEKNENINQNQNEIEDINKNLNENQNENQNQNQIENQNENQNENQNENQNKNKNQIENEIQNQNQNEIENQNEIQIENQIENQNEIQNQIENQIQNQNENQNQNQNQNQNQNQNENQNENQNQNQNQNQNQNQNQNQNKKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REH7</accession>
    <name>A0A9Q0REH7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REH7"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="317"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="47187" checksum="B0D890C3E6FD854C" modified="2023-09-13" version="1">MNEILFFGLNEYPKLFKNEPNEITKPIQFKFENENENENEKQIKQISSSNFGTIFLFKNGKAIEYLNENDSNQNPEEIQIEENIQKVSVGYQNEAILTKEGNAFAKGYDINYENINQFINISSLIEDTNDRIIQDIVSGNSSIYLLTSNQNVYGIGDNYYGKLGFDYETLKETEKPILMMKNVSKIFSGNSSAHVFLLNSNQELFGCGNNQYAQLGLGESRKEETEIQKLTQIQNIPKGKIIDIQSGYNHSIMLIEDENQNPKRKLYSCGYWIYNGLGEDENTYEFTEIKSSLFENDDNILDFSVGSVHNLILTSKGKLIGFGNNRYGQLGTGDTYFYQLIPLQIELPKLRFNEDISNYHLSCGEFNSFLYYSLSSFSNLEEDLIKLFERKEFCDISFKTRKWRNNQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RES5</accession>
    <name>A0A9Q0RES5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RES5"/>
    <dbReference type="OMA" id="FEMCFIN"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="426"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5078101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="628" mass="73931" checksum="AECBA38BFCEE99FB" modified="2023-09-13" version="1">MNQIEKEIEKEIEKENQIFTLIEKQNLTKIQEILEDPDILNIKNKEELTPLHFACEKNEEKTKEICELLIRHGANIDSTTTNKKITPLFLASGSGNINTVDLLISKGANIDLKTKEGLSALHNAAKNGKTLICHYFLTLDHKNQNFNINQLDSNLHSPLHWACYFNHVDTAIYLISNHANLNIQDKLGSTPLHWACQKNSFEIVKELVLRGAVINIKNNQNLTPVQIAQNSGFLDIVNFLNYVQKNFLYRNFFGKTNNQSLINQQERNPQNFYYDGMLYSFVDFRLFVRITWTIFYILPFLLFLILIHFSSSISSFIGVVFLNLVVLVPFFYFLKWPLILFYYAKNPLKASILSSYLFEIISTTLFQNIPQIYSQQYFLVVIFFFFFIFTSIAYFKLRTANPGYIPTNQISSRNLVEKINNHYLTQDNFCHSCHSQISLRTKHNPVQGRCIAKYFKWCPWLYCDIGWKNERIYFVFIVSSAITHFLILITFWKFIMINPNFPNSLFPITQFISEIYKNDPKFFIIFIFLLIGLFLQVRIFFHSIGFIGQNLTLNEVTSVWDYPYMFNSNHQIRNPFDLGYELNWKQFFGISNQINWFDVFRLEDVSTDCISRICYRELYSEERINQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RET3</accession>
    <name>A0A9Q0RET3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribonucleases p/mrp protein subunit pop1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_05947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RET3"/>
    <dbReference type="OMA" id="RRTMSHN"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="6">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="7">
        <location>
            <begin position="543"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="8">
        <location>
            <begin position="726"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="218"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="797" mass="94273" checksum="819B4D63F9040009" modified="2023-09-13" version="1">MQKQETQIDVVEYVKLSSQTITQLKNEINKKHTTKLSWQTLPKHLRRRTMSHNIYKIPRRLRQKAQKEFEKQPPKKPKPRNRKQRRKPSQLIEEYTNRQKNKKWLETHIWHSKRMKMQDLFGFRLAMNPTEKVLRASHKFSSYSCTIFDKSFYTCFELIGNQNQIFHLFSKITPPFTSSVANMMYLSGGREGFCLIYYPDSFPSGFLCSCSFMWKFEEENIGMEIENQNQNENQLENEIENQNELENQNENQNENQNENQNENQNELENQNINQNINQNINQNINQNQLENQNINQNENQNQNENQNQLENQLENQNKIRHLWIWIHGGISEKVFQMFQELIKKEFPEISIKNLQNELLRFNLTGPRSLSYLLTILKPIKQNYQENENENENENENENQLKNQLKNENKNENKKFSQEIIWEALKGIQTQASLPSSFILGLTVLDPRLISIKEAKKKRNQTFPLNQKIFHQIQKKWPSYLAQSPLWEEKEREKMIKKLTEQKISEQKSQLLFPFATHSIKDQINPHILIIQKTTQVSSGYGSGFDIIVPKTWGVAFWRALVFCGAMALGMRDAHNIKTEQGSCFFPDDFPDSILFTQSRSYIEDTQKENKHNRTPISKRTNFKKLNSLSPFHPNWNLIFQKEKNEENSVFVYRIFSRLPAHQITLKFPQNQDLLSFKGNGLVGIQVLASNRGLPERNAMIYIPEEEDLKKFKENKQCLIQKSQKSQEPFRKLIGFITSGRFSMSRGCGFGIGFCSLDEIFDKDGILRKKKWIENFLILFRLPSSKIYHFGSFDFIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REW6</accession>
    <name>A0A9Q0REW6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REW6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="236" mass="28356" checksum="5BA5FD58F7E922A3" modified="2023-09-13" version="1">MNTNRNQTEKPNQKLNQKQKPIKKEKINEKDPKNQQNQKTQEDQIIHEQNNQKNEIKEIKIEEIKIEDQKIHDQKNQNLNQIENQIQNQIENQIQNQNQNQIENQNQIQNQNQNQNQNLNQNQNLKKVHPKNHSNQIQKNQSSQFTQIRKNGYTKNHSNQIQKSQSSQFTQIQKNGYTKNNIKSNTKSKKDNPIQLQIQDNHIHLKIIKSNSKYKIIKSNYKYQHHHQTLKKTTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF96</accession>
    <name>A0A9Q0RF96_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000052">
        <property type="protein sequence ID" value="KAJ5078641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF96"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="347" mass="41714" checksum="BB880E90B380FD75" modified="2023-09-13" version="1">MSIYNQIFHSKWVQLVWKKLYNQQETINIIETIKNSDEKLNKILNKFVQQLFTFRELEKYIDLGMSDEDIDEEVKLLNLATNGNFKSEILKQYKILRQFDKNYPVFIHFCEKFELKDKEFEEFKSIFGKSIENKTLKDVESLYNLYQKFIQGLNPEFFSFLSDIFPIKEVRDGVPIFNDQLFNFMKDNTDDWSNVMELIDEEFFIFEAPFDYIRSRLEKFLSEEKSKITTLSNLINLIKENEKNWKEKLSLGFNQDQQSRTIKQIFISLPEIIDLIRQKLETPKKKASKNLENILSNSNKTFKFEIKDEIEFECEIFKLKEKNDQNKFSFQDFVDINMLLLENEEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFT6</accession>
    <name>A0A9Q0RFT6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFT6"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="287"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="59742" checksum="8C236C84BDA02D7F" modified="2023-09-13" version="1">MNDCLFFGYNKDMKLFKNEPDEITKPIPFKFKNENENENENEKQIKQISSSQFSTIFLFENGKAIEYAKYSNQYPEKIQIEENIQKVTVGDDNVAILTKEGNVFAKGSIINPNNPKEFINISSLIEDKNDRIIEDIVSGWNSIYLLTSNQNVYGFGANYDYQLGFDSEKLQKTEKPILMMKNVSKIFSGNCSNCVFLLNSNQELFGCGYNYYGQIGLGESRKEERNIQKLTKIQNIPKSKIIDIQYLAKTQNTYEFTEIISSLFENDDNILEISVTFKHTLILTSKGKLIGFGLNESGQLGTGDRKNQLIPIQIEFPELRFNENISNYHILCGYWNNSFLYYSPPFLSNLEEDLIKLFRRKEFCDISFKTKNGEIIEVHKLILKYRLNENQNEIEKLQEIISKKPIKESNQIFEMIYSNRIINPKLYYEIKEIINSNEKIEETMKKIYLNENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFU3</accession>
    <name>A0A9Q0RFU3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFU3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="384"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="550" mass="67270" checksum="335D5A85D08E73C0" modified="2023-09-13" version="1">MFGNKKTSDFQIYCGKDKISIPCHKSILEARSKYFMINRRENKFNSIYFNNFSSEIVKPIIKFFYNGKFKFDKRKFDEYFKFANQIKLKEIQFKIELEIQSIFNIQNILEIYFKSQEINSQNLSQNCEKFIFQNIQFIISNPNFDKYLNQNQIYNFIGLISLNQNIPNQLQIIQQIEQKWNQNNQKKLIKLIKFETNQNENENENEINENENSFSNLLNQISQTKSINQFQIQQIKNKFISQLQNKTVLLNSNIQEFEQENQITEFQINQLYEKKRIIQKEKEKLEKIKKEIEEIKEEYEKWKKEIQEKFQQLIQNDEKMKKEYLQEFNKRIINLKDLFEQNRKKDLEIFQKKIEEIQNKFKKRKNINLEEIDKKYQELINFPKLKTEEDLKLFEETIQQFKNEFEQKKKKEIQEFKEFIQQNKIENENENLEKIIQEIKNKIKFKKNKYLEKIEKKIQEIEIKNENLNEIEKIIQDFNNEIEKRKNEFYSKINPQIKNIQNEIENQKLKIEILQSPEKTTNFLQDLSNSIQQQDQSKSNSKTKKKENLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGD0</accession>
    <name>A0A9Q0RGD0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000039">
        <property type="protein sequence ID" value="KAJ5079092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGD0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="71" mass="8438" checksum="D7FAC568A4A08825" modified="2023-09-13" version="1">MFSLAVTNIIIVIFFFLCLLICLNLAVQYAFKNSIIHKHCNSYYLSHFAVFFIIITRTKISIVIFIYFYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGM8</accession>
    <name>A0A9Q0RGM8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGM8"/>
    <dbReference type="OMA" id="QEHTRIC"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="652" mass="75342" checksum="5FBEED81153A3AAD" modified="2023-09-13" version="1">MQKEKLRNYYECKNNHKICMRRKCKEKINNKQEHTRICPVCNEEIFPQKNDKSKNKNEEQNQPENKDKNKRKHKHKHKNKEQNDEQQNKPQDKKKNKKKSKSKNDEQNKEQNDEQQNEPQDKKKNKSKNKNKEQNDEQNDEQQNKPQDKKKSKSKNKNDEQQNKPQDKKKSKSKKKNKEQNDEQNDEQQNKPQDKKKSKSKSKNNEQNDEQQNEPQDKKKSKSKNKNKNKEQNDEQQNKPKDKKKSKSKKKNKNKEQNDEQQNKPKDKSKSKSKSKNSNESSSLSSQNLSSNLSSSPSETKSENSDGNKKINNLSKNQSKSKSSDEKKSSNESKNSDENKKSNNLKKSESKSESKSSNESSNESKSSDENKKSNNLSKNQSKSKSSNESKSSNENESKSSNESSNESSNESKSSDENKKSNNLSKSESKSSNETKSESSNETKSESSDENKKSNNLSKSNNLSKSNNLSKSNNLSKSNNFNQNNLNQNNLNQNNFNQNNLSKNNLNKSNLNQNNLNQNNLSKSNLNKSNLNKSNLNQSNLNQNNLSKNNLNKSNLSKNNLNQNNLSKSNLNQNNLNKSNLSKNNLNQNNLSKSNLSKSNLSKNNLNQNNLNNQSQKMNPVQKGEFQKVEQIQKMKLERKNFWILYFSQKFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGW3</accession>
    <name>A0A9Q0RGW3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FACT complex subunit SSRP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_14552</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGW3"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SSRP1/POB3 N-terminal PH" evidence="13">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SSRP1 dimerization" evidence="11">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SSRP1-like first PH" evidence="14">
        <location>
            <begin position="271"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="414"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5079168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="471" mass="54881" checksum="48F45A75D57A51E6" modified="2023-09-13" version="1">MAQKPKGHLFKNISLLENEAENGDLKLLPLAYVWISTKTQKKKQIPLRNIKEVYWYPFSRGSILKVLWKTSTKNEEKEKEKEKENENQNQNQMKETSFFGFQSNHYNFLRKYILDYHKMDLKKVEMATQGLNCGDIALKENSLYFYVNGKPAFDFPLKNVSQSILQSKNDLTLVLSDKTHENSKVDSLSQIRFFVPLSYQVPSDPNPDGCVPNGYVLENTKEKTNVETGLGAILEPKKILKKTTTQNNEIFTAEQFDKEIRQITDASVTGDEIVSFKDIFLFSPRGRYKIQCYPTYFKLSGTTYNWRIEYKSITEMFMLPKPDAEQAFVIVLDAPIQRGKTKYSHLIFQTFDTKEIEVELNLTESEIQEKYHNKICKDLTGFQSDIIKKVFRVLIKKPIQSPHKFKTSEKTPWIHSSFKTSEGFLYLLENGLFFIHKSIHIKYSDIATIDFSRLDHSHTASQLNILNWKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH28</accession>
    <name>A0A9Q0RH28_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH28"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="352" mass="42467" checksum="6E084D581151B820" modified="2023-09-13" version="1">MKKSKTNQTKKSKFLQQKRIFIKLNHINLNLTDSNKTSSNEEISEDSETDEYENEKEDLIEIKNENQTIFKEKFINDFQNLFENENNNYSDFVIKSGKKYFQFNSHKSILSFRSLYFALLFKEKSINQIEFPEIRKPIMKKILEYIYTSKTQISKSELIEMLIVSNQFQLNLLSKFIENEIIKNINEKNVCDYLLTNQKMKSNQLENECLKFIIDNFDKFIQQNNTFKLTKKQMKYVIEKGTTKFKKIGIELFEMIKKWIERNEQKNNNEINQNIQKEKFNKIIEKFIPKINIKCLKNKTLKQIKKIEFLPNIFLIGIENLRNERIYQKQKLENEKEKDEKSKRKSRNETNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHG8</accession>
    <name>A0A9Q0RHG8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000047">
        <property type="protein sequence ID" value="KAJ5078719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHG8"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="494"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="67685" checksum="D9B2CF0D1D6CF21B" modified="2023-09-13" version="1">MEDLIKIFQKSNNIKEIKKALKDYPEENLNQGKTPLHLYLTQKNKKIEILEAILKMPKLNINAKNNETPLAVLLKETDSSNFLQFVEKLLKAGADPNLVSNSPLYRLSQHSSQSNELLELLLKYKINPTPTNMETALHYACYFKADLSTIQLLIDYGADVNAKSGYSPLHYECYTGPRKESILLLISKGSKINFQHGETALHFAIKASAPHEVIETLLDQGADPNIDDKSSGFSLICSSTRYGVETFEKMLQCSADIKSDKYNGKTPPLISILNHNNFLHLVDLFAKYGANFEVSNGDTPIIAACRQKITQSSIHKLLEFNVNVNAKNGKTALHYASSESLSTQILEDLILHGANIDEYDYNKTPLDYSSNPDVTQFLQSFSSLALDYSLLLERQELTDIEIETIDKTIHAHKAILQARFGTDINFNLALSILKKKTYKEVYPFIQFIYTGMIKGSIENLREISKEIGINFDSKIGRKGIVDDMMRLYEDESSKDFKIIVDDQNIFVHKFILLARSDLYRGMFINVHDESNAVTDYSGKSFQTLEALIKFLYLDRFDSNLSDEVIDELADASDFYQLNEKINLDLKLQESGNIINRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI83</accession>
    <name>A0A9Q0RI83_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trivet isoform i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000007">
        <property type="protein sequence ID" value="KAJ5080593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI83"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47678">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47678:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="218"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="389" mass="45406" checksum="B8C40CC12340AE5F" modified="2023-09-13" version="1">MSDKKRKKSIDDNEDALGTHELDLKEKYKILQSKTPQRKEKKQELSIPEIKILRTTPQSNKKITLSAKKSLDNIQKIENAKKILAREGILNQNQKPKVIKRPSLRFRNSNKRANLTETNQIQQKSKEQNNFGDSNQNNNSEQNNDNNNNNNNNNNNQIQNENENENENENEKENQNENQNQNQNQNQNQNQNQNEDQNQNQNEDQNENEDDEDSQSSLTIWIGDLNDSINESVLLKLFRGYGAIEEIRRYPGKTFAFIKFSEEEAASNAIKHMDGYTYNGSRIRVGKAKLNNIVTNTQDYHRLNEKITISTIEQRHILENELSWAYQPAPIISYKLEEDEKNNSLNVNNEPQKNEKEEIKKEEIKKEDNHSSLQIGIEKERGVLRYDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6K1</accession>
    <name>A0A9Q0L6K1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6K1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="221" mass="25954" checksum="6F19782A23218E38" modified="2023-09-13" version="1">MNFLLSLFKTKKQPEIKEEKSVEEALLEKKISEANELIKQLETELEKIFDSQKKEENNKENKENEPKKRIPQINQITQIHQINQIHQINKINKINKIGQINTINQIDLSQFSNKSKFFRPNNLKIQKNPFAEELDSPVQVEEPIIKFNQLNGFKMDDSEKGKLVISQSVSNQNITDWIKNDLEFENENENENININEKSHDLLKELSIEFITQNAKQLTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L786</accession>
    <name>A0A9Q0L786_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter h family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L786"/>
    <dbReference type="OMA" id="AMLQRMN"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000032">
        <property type="entry name" value="Export ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF688">
        <property type="entry name" value="ABC TRANSPORTER H FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220">
        <property type="entry name" value="IMPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="39"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="358" mass="40388" checksum="0DB129B4BEA36FD0" modified="2023-09-13" version="1">MKKNESITQDLLNSFSDLELDAEEKAAPKTIENEDKNLIELKNIHKTYLIGVEGVAALRGVSLKVKRGEFLIIFGKSGSGKTTLLNIIGTIDTPTKGSLSVCGTKISAKTKDKTLAHLRLKRIGFVFQSFNLLSLMTALENVEMPMILDGSIPSKERRSKAKKALKRVGLSERLYHTPSKLSGGEQQRVTISRAIANSPDLLLLDEPTGDLDTKNTKIVLHLLLNLNLKENVTLVMVTHDITLKDFADRVIWMRDGLKLSEEVINPERKNNVRKSLLDETNDWLQVNNLAFEEDSFKSSNFQNFQNTTFRNPNQYKHLKNSSSVKKRTQITKEQIMQELGKIAPNVSFKKFYSDQETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7D6</accession>
    <name>A0A9Q0L7D6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7D6"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF4">
        <property type="entry name" value="PHR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="263"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="490"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="599" mass="70121" checksum="18A71FA1D23A0EDB" modified="2023-09-13" version="1">MNEIIFFGSNRKPKFIKNEPNKIIKPIQFKFENENENENEKQIKQISTGYYSTIFLFKNGKAIEYLNENDSKQNAEKIQIEENIQKVTVGWDNEAILTIEGNVFAKGYDVNPNNPNEFINISSLIEDKNDRIIQDIVSGRNSIYLLTLNQNVYGIGSNDYGQLGLDSETLNRTEKPILMMKNVSKIFSGIVSYHVFLLNSNQELFGCGNNEQGQLGLGESKQEFKIQKLTQIQNIPKCKIIDIQCGYVHSIMLIENEDQNPKRKLYSCGNYKFNGLGKYEHSYEFTEIKSSLFDDDNILEISCGIFHNLILTSNSKLIGFGDNYSGQLGTEDTNYQSIPIQIELPKLRFNEDISNYHIFCGYEKSFLYYSPLSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINLKLYSEIKEIINSNEKIEETMKRIYLNENENENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNQIKDEIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNKNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L816</accession>
    <name>A0A9Q0L816_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aprataxin-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L816"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="270" mass="32159" checksum="2949460D37048C90" modified="2023-09-13" version="1">MNFVLNSNSNLNLINFKSSTKYLLSSLSSLFTKRYFVFRPKNIFMEKMKKLKISKKLEKNMSKKGDIEKYDPNLFGKIANQKAEYDKNRLILYQDSEIVCLEDAFKISEIHFLVIPKTKIETVNQLKANHCGMVKKMYRIGFEIAVAYARSLNNETGKIYRKMDFHELSKRFVCGFNLPVSIDWLHLHASFPPFKLSNCFRYPRFNPIENVIFDLEHFQKVNPFILNFKENESELANPDYKMNIYWRDKIRDNQKDILEKIEKEKNKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8E6</accession>
    <name>A0A9Q0L8E6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dactylin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8E6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="399" mass="47840" checksum="6AEBF228BFDDAF27" modified="2023-09-13" version="1">MKKFIPFQNQNNSEIQLNKEDFQNFQFGKTIKMPSKLYEPPKTENLIIQMLPDEILIQIAQFLSPGALFRLSMCCFHLRKLIQDQYLCGLVIQNHYKYFVLKEFEIKFGFYNSNPKIIAHFDPSLIENQKGNQFEILNKKGDEFKSTFKNLENFIETKRKNQKEYEKQIAKEKHDENMFKKSTKIFIFILELFLIMLNISIEYSIPIRVSFHVLILIISSFPSIYYLVKKFKAKRNFMNFLFLLISFLLLLLLLLVFLKFSNILNLKWWIIFLPVQIILFTSSISMIFFDNFCIFFLTPLLISLFLFLVCLKVDEILIIPFAFCFFPIWILQLINFIGIFRLKTFESFQDYFSLFLFIALIPFSLLLFLFWLFLEDKINRISIPFSLIHFLFLFFLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L953</accession>
    <name>A0A9Q0L953_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-anchored lipid-binding protein lam5-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L953"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="249" mass="30103" checksum="2EC9A50764AB3A22" modified="2023-09-13" version="1">MKIYELRKKFQLPVTEKLQGTFSCAIKKIILYHGRMYLTQSYLLFHSDNLEDVEQIKIQFSQIKDIDLAQVTKSINFIKIIVENEEYFFTSFTSRNKAYSLLKQLWLKERSRYLLDESKEKLNENQNQIENQNQNQNQIKLKKIKIKIKIKIKMKLKMKIENENQNQNENQNQNQNQNQNQNQNQNQIENLKNDSQIKLKNKKSLFKIKIIFQNQNQNQNQKSKSSRDSSVFTQEKSRKKFFFQNEKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L972</accession>
    <name>A0A9Q0L972_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L972"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="157" mass="18797" checksum="EC7CE63B9323C92A" modified="2023-09-13" version="1">MIQIFILILNQKENLNQLKKSKSRNRKIYIPNLNINSEEKELFNSNQLIGKRLDILAKIRPDLIKGWKSSTFKCFKEKGIIPEKVIIHDDGFHFMAQCLEITNFEELNNPTQEMKLKYQKFQKNYKRSLQKFLQNTMKMKRIKTNGKQHQPIIFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9F9</accession>
    <name>A0A9Q0L9F9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferm domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9F9"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="1">
        <location>
            <begin position="93"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="438" mass="52485" checksum="5E59ADB04911EC77" modified="2023-09-13" version="1">MTIKNEAKVNLIHQKNQIMKPIQEMKKKLKDFLEKVKIDYQKLETFQKIQLNLSKEDNFEIRKKKIHHIFMQSRRISSMNKLETHEAQYKKALKQIVRIFFSDSVFKTVPISEDHTVYDVCCLVKGIIKKYGLEEEFKIQPDFVLVEKIGKEERILDNNIKVWFIKSKWAGENKGDFYRLVYKSRSGISDKTLVRSETSMVVRFLLEDYSFISLKITNETTCNDCVFSLKQKLALNSNFDPNKPQYYLFEKFKNSLRRFDGSEKIMSVINFWEQNSIDAYFFFQDLNPKKKIPIFEFSVPEKRRETIRTYDYRRKPTLSMLKNFEKTEKNISQNEDIGGVFELYFPDEKIWKFVFVTITNNRLYFYQDSQQDSGQKKFNLFETKIFPLSKEESEKFGKENIFVIEKENHQWFLSCNSQDLMKKLVSFSFPNEKNHKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9G2</accession>
    <name>A0A9Q0L9G2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9G2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="243"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="348" mass="41585" checksum="8071A76A2D1EFDD0" modified="2023-09-13" version="1">MLIEDENENENPKRKLYSCGFFLFNGLYQEKYSKEDTYEFTEIKSSLFENDDNILDFSVGNAHTLILTSKGKLITFGNNFYGQLGTGDTKEQLIPIQIELPKLRFNEDISNYHIYCGFWKSFLYYSPSPPSFSNLEEDLIKLFERKEFCDISFKTKNGEIISAHKLILKYRLNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNRIINSKLYYEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVKDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9I0</accession>
    <name>A0A9Q0L9I0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tbc1 domain family member 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9I0"/>
    <dbReference type="OMA" id="LEFNSWE"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="25"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="589"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="697" mass="82585" checksum="BC13D515F7C245FE" modified="2023-09-13" version="1">MNEFNKILENINLKSIREPEFLDRITETNIRSFTWSLLLGCFGEKINRGNFLQILQETRTRYEILREKYVENKVIPLFENNSEFPNKVDMNELHRILVLDVKRTDPQSELFAKKNIQEMMKNVLLIYVYENQRNDGYKQGMHEILIPVIYILQKDLEYSRIEREKYQNQMRENIEYFSFFNENYFEHTIFLLYEKLMKIISPLFISHKQNLTPSLPEKVDEKVIKEEYHEVISEFQLKSDEIQNVILFSKDPDLSNYLKSKEVEPGIYLVRWTRLMFLREFHLEDVLIIWDSILGSENPLKFVDYFCVSMLIFIREQLFSLDNQSGIFDRLLKYPPVENVRVLIKQARELLHTKHKMKFKFKPISQSEKKTKSTSKQNGQNKNTSKKIRFSAHRHHHSIDIPETNEKNILTRVHTQTSLPQDLNNSISRKQIFLDLDSSNPSKVQKALSHLSTDQQLKILTDHVLKTSQTQLKLGRIVSTIIQQFEDYVRKTQELKPQIEIQDSNFDILNSDSIFEDIALLKQVKHVLIHELSFSDFDYSYRKQNLRKAKEIGHQRTQSYQTIMKNNQENSFETIRRNQNQKINEFQTNQNNSNQNNSNKNNSKNNSNQNNSNKNNLNKNNLNQNNSNKNNSNQNNSNSKNNSNQNNSNQNNSNSKNNSNHNSNSNNSNQNNSNQNNLNQNEQNHKNYKNHKNHKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9K4</accession>
    <name>A0A9Q0L9K4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9K4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="278" mass="32891" checksum="D993A2660B503375" modified="2023-09-13" version="1">MDSIQEEIQQLQNEILIKSKQNEQINYLNHDLTRGLIELEILLQNSIEKIEQFSKIEEKKEIKNENTKTQEIIINEKEERKKPQKTSSFIQSLLNPTPRTHKTQNENQPRSKTTLKDRIKQEILNQKMGKKKEDSEEVIQKSKSKSKLKTNKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNSEKNELIIQNLISRLQNKFKQNTSFNSSQIENSDLEKEMNQIKLELDQQILEITQEIENQPQTDEIIDFQEDESDFDDEILSSTSQESDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9Q4</accession>
    <name>A0A9Q0L9Q4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein boule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9Q4"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF57">
        <property type="entry name" value="PROTEIN BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="233" mass="27026" checksum="3125201A1883F3F7" modified="2023-09-13" version="1">MSDIRERKLFVGGINSKVDEAEMTNFFSKFGVVLDCKIIMDRSTKLSKGYGFVTFEDPKVAEELKRRKSIDYMGKTMDLGAAFRKEDVPEQEETSQQQRKYQPIFSPQAYADYVSQFYGFAFPNASSFFVLPQTQPLNSQFQNSNQNQNQNPNQNQNPNQNPNQNPNSNQNPNSNQNFNPNFNPNFNPNQNSNFNPNFNPNFFQQMQQFPFPVQMPNNSQQMFPFFPSNNLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA13</accession>
    <name>A0A9Q0LA13_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Wd-repeat protein interacting with phosphoinosides wipi -related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA13"/>
    <dbReference type="OMA" id="GGPQCMC"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="343" mass="39344" checksum="4EF68C0EEA09C136" modified="2023-09-13" version="1">MTKNIKKNPKSIFITFNQTNDLFCCGLHNGFKIINCDPFEEKLNRTFQETGISKIEILNRSNVMVFVGDGTSTNFPLTKVFLWDDYVYKCILKLEHDEDVLGVKINLEYIFTVTKNKAYIHNSKTGRTVHTIETYPNQKGLLSICSDTFSTVIAIPGLKKGSVRVRNFSQDNEFDQEIIAHEHEIEQIQLNSDGSMIATASEEGTLIRVIESQTGKEIKQFRRGAKKAKIYSLAFDENSEFLAATSSSGTIHIFRLTPKKEKKQSEKKNKRGETGTERSVMKTKIPNKEYCVCGFDKSSNLFVVTIDGSFYKFYVDKANRQIKQVKEMYKQFLNIHDEKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA32</accession>
    <name>A0A9Q0LA32_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sh3-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11240</name>
        <name evidence="2" type="ORF">M0811_12605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA32"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="137" mass="16788" checksum="5B43E97183C896B8" modified="2023-09-13" version="1">MNDLKDLKDFYSGYLLQKSIFHRWNKKYIKITNERKIYIFKEKNDKKAKHEYQLSSYEVKETPISKFKKANVFYISMKDLKRKKKKIYFCCNDQRERNNWIESIHYLFNQQKNDIKQALTNQSLQNLSPTSIQPEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBS6</accession>
    <name>A0A9Q0LBS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBS6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="66" mass="7814" checksum="20B0FEBBBE4F4B11" modified="2023-09-13" version="1">MEIQNKIKRSKKRNMEFKIDIKKKNSKISMNKALVSAIHETNESPPNFIFTIKSKDGKIYYLQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCT2</accession>
    <name>A0A9Q0LCT2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCT2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="199" mass="23598" checksum="0B58189918970BFC" modified="2023-09-13" version="1">MENKEMKIKVGLFGSGGVGKSTIAIRFSKDIFVEDYDPTIEDEYKKENDLNNKKILFYILDTAPQEEHYDPFPRYVQYTDIFVLIYSITYKRSFEDIKYFNERIKRILDIEDKDYPKILIGNKSDLTMKREVSIKQGKELAKKLNCKFIETSAKTGENINQLFYETILLEIERLKTIEEENLNQKKKKKKNKKGKCFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE02</accession>
    <name>A0A9Q0LE02_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE02"/>
    <dbReference type="OMA" id="RAYYYQP"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="108" mass="13532" checksum="1163930758BDE287" modified="2023-09-13" version="1">MTNLETKEQQTKRHKPQIEKEMLTKKQERKEQKEQNQNQNENQNQNEKQNQIEKQNKKQEQNENQNEKQNEKENEKQNQQNEKEKELLSKMTKRKERRAYYYQPKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEK0</accession>
    <name>A0A9Q0LEK0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sca1 complex scaffold protein scaa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEK0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037474">
        <property type="entry name" value="ScaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516:SF1">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1056" mass="125999" checksum="BCF02C81A5A39C86" modified="2023-09-13" version="1">MNKTNPNKMQINSIIKENQENSKDIFFLDLNGFKYDHNYFEIQQNLSTNSFTKFPNSEDFKTYKEFSNAIIQWKNSFNLELQNLKLPSILGRVYPRPFFHSNKKSQEENSDSSRNSLDTQKNIINQQKQLLKLQNNCLNSCEFEQKNDIQNFSLNEEKKKLLQKQNLNWKYSLIPQKPKPKYYETFEEYEKAFLNWQKIINSSVQIIPPNSLEIIERFKIKLPEKKQFFQKRKFSRMNQKKNSQKEKFTSKASFYDWQLKQYQIMTDFLTFKLPIYNSLNDPNLKNIKTKLKKIKLSKFGSIFFQQKSKRRNAITTSFIAKENRDNLNDLDSRSLFSIPNNISNNQKLKISFQIPEYDFKEKINWSEQNEKNRLELSLEFKKKEIEYKLDKLQSINYPILNERIAERIILKKEKMKKYCHNLDNISTIEIMMDLILDPLIFLDTFQKLLIQNYIIKGFMVSFFHSISLKMSLSEFEEILEIFLYSNSFLTHGKLTYFVLEILKDTYEGNFESSDVLSDYISKHDLKHLFYITYATNFKNQKAIISPSNEIGLKNFTNRYFVVNILLHYYTSLIRRNLSGIDFYYVNLLEELKKKLEPLTNSFRITMNEMVVKDIIKDISRPSKISSLFPALLLQYLFHQNETFDEKQSCLSNINKNLKELIKTLLDLHKTRFNHVDYCCSWIWKTLMQQISLLKIMIEKCNTSFLIEIIEIKISKNQFRYLFHFSERIFEYIKYLIQEKEKTENINLRSQIIDMISSVFHSFVRLISRNTSNTILPKNQKNSKNFIYISNFWKNLTSILVLIMKELLSKSKQEISQKKLKKKKKKEQAISIEYISHITSILLNFKFDYQQSKSDLVILLKKFLLTTHIQQKEAKEIFFGIFLAFSDSNQKNYCKNLWKLFDLKTLGLITKEQKKQLIMLISPQLPIYNQIYGISCIRKIFESYNNQKLTKKVFKELSELAKIITSCFVQLKMIFQSLVDKKLFGWQFIEIHHLFVVISTHQAFSKSYLELIKKESYRKFFLFFQSQSFFQNLNSNSNSNSNSNSSNNSNEKIVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEX5</accession>
    <name>A0A9Q0LEX5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Atp synthase gamma-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEX5"/>
    <dbReference type="OMA" id="KCERHEF"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1097"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1200" mass="142482" checksum="B85EC788E39845BB" modified="2023-09-13" version="1">MNEKNISVEIFTMKENEWKSEGIGILNIEINEKEIEIKLLYENQNQNQNQNQNQNQIQNENQNQNQNQKNQNLNQNQNENQNENKNQNQNQNQNEIENQNQNQNQNQIQNQNQNQNQIQNQNQNQNENQNENKNQIQNLNENQNQNENKNQNQNQNQNQNQNENENKNKNENKNQNQNQNKNQNENQNENQNQNQKNENQNQNQNKNQNQNKNQNENQNENQNQNQNQNKNKNKNKIQNKNKIENENNIQNKNNIENENNIENKNNIQNKNNIENNIENKEIKYKLENNSKCTIQQGTILMCESSKKTQPIFAISFQTSIECKQTLEFIKKNIELENHKENKIILNENIIEDPLDYEFIVSNDIIDFPETEHDITVPVSPNTSNNSSINLQEMEKLPFPYEENLKFIATLLSDHPFYLKFKLISEILENEFILNLIDLFHKIKEKFMQNKNTKSWESLVFIASIFKALILFGNSKILDIIFSKDLILSTIEILEYYFPDIEHCKKKLEKASNHLEFLTKKAKFQTIIDFGTQITETIQYIYHLDYLKDTVLPSFVDEPILFYINNMSITNKQEILKYIYGDTKFVSNVFKKFKSTNPTSKEREKIIAFLYELYKTTATVEMKFEFSFAKEFNEAEIFDILYESLQDEKEIIKKNSLSILSVFVSRNSNLFRKYLKSRAQINSGYSFAMLLVKIIHSDPHSGTRISILNLFRNLVDPSQFIDFIEKEDWVEFFFQIIFPNLLNPISSQKNLNKNINLQNNSNSNSNSQIIFNDFVSCLCDFLTFCNSTYLQKTQNHLIQNQILQKILLQLELSNANHTKLSILRFFREILLLNNAKYYSNIIQNNLFIHIFHLIDKNIQKDNMLNSALRNLFKTILQKKIKIILDHLLLDHSKYIEKYLKIESFGSIFQDLLNSNLLLNETPTLNPNNPFEESLLNEIPLLKRQNDSKNEKIIDSKNIQNYSNLSESKFLQDKLDSLYKMADPNQPEFQIETKIRNTNEKFTNSFLDISNSSWITNMKMKKNDQNENENEKILKKKKKRKSLVIYDSDSDSDSDSDSENEKEKEKEKEKNSFQKKKHRIRRKGIIKDLSKLYEENETKDFTIIFDNEKEIKVHKLILIIRIELFKGMFLNVQDSSNQVHDYSGKSFQTIQEFIYFIYHDKFSKNIKKEKEIILEEYFDLKDYYQLNQNSIIDLLLKEENEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFB5</accession>
    <name>A0A9Q0LFB5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gata transcription factor 17-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFB5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="655"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="861" mass="101360" checksum="7D02AA7EEC21BF27" modified="2023-09-13" version="1">MELNNEIKIVLDAHPPTQEIVEQYLDDGTEILREETDTQDVFLQWWQHHHELEKKQESVLEKKMNESAQISENLVKAKLELQHLDKILEQLLEEKYLVFDFISKPDDDTRNENEESCAKFVRKKKVLKEAGEMLKKMSNQAKEEVEKDQIFLEKLKQVLTKWNVILRKPSRLFVDLSPLVTKDYPFIPEIIKTDKGDLLIQTEKKEQVILQVICKAYQQNQGGEGLTSLLDFLKLEIDNDHDWNYQLTRIQQNIFQEQLFRDLRKVFETFPVGNGYSYCEIATESISCQTESGYSIFFHLEQSDGLDITENNNQTHENLVADNESTLAGSIFKCILQDMYLQEKTRKKIDSNLFSVATEAGLFFSRDEMIKRNYSNQRKLPEKFIMKTNYMKFSKACLVLFEKIAAHTQGLVIHLLPPNDLNLTIDFEIYYFQRRKLLSIYIPKLKDRESIDIIQNWLLDFIAFCIAEDLERVANSFVYHLTVLEPRFDEKVLEQSDNNHLAFVENIRISHGHWRIVVERLKLNNSLTVDIKSDLKNSRVSISYNACYEFIKFGSWSRIPEEKEKEKKKKRKQRKLRNRRKATEDPADFDDFECSLCKTKETPQWRHIPKWYPNANESDCICNRCYSQMLRKHKKELKKQTEMNYEQNEKIRQNQKEGLFNNLKISISRGSLPKLTFVSNLKASIKLLITENNGIISNENPSILIILSETLPSLENIESQSALKILLALCNATPVLKCPWVNHVIDKEELTDMDQFSFFPIIPNFQISQKPFYQKKIFFQCSFGDSIRNTWRKVLEESGAFISEKVTSDLDFIIHEEIPYNDFLFNLIHEKVINQNVTKMFTIQEFINFLIKHIDFLSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFL7</accession>
    <name>A0A9Q0LFL7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tenascin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFL7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="445" mass="49415" checksum="A825CEDC72AED4B1" modified="2023-09-13" version="1">MKCGESSSFINLTTKIDSVKDFQLSNPSNYSINVTWNYPNVQINEEIAHLDHYNLSYLNQSQPDLISFISVDNSSLDYLLNNLESENDYNISICGCRTQECEEDDKGEIVESSISLLFGEVTNLTCSIQYSIDINCNWNQPINCSIPFYYNLTYQSISQNDSGNYQPTSSNQQFATQFQNQEYQINISACNSNEKCGYISTISITTDNLTIAPTIYETISKIEEIELNFTKLTGAYNYSISLDNGTNWQNLTSLNLSGNEAIGTISGISGNIEYNISIRGCSDLNCETPYLGLPSSIISARAKLGNITSLNCISLINGFICTWNSLILSSGLKSYSFKFNSISICLTNLFNYYLIPSGLQGGEYYEISVYSSADSNCLDNEYSGINSTTSITILSPYEPTQSTDSNNSNTTTITVGILIPIIIILIVIIGILLYQKKTRKNNPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGQ8</accession>
    <name>A0A9Q0LGQ8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_10182</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGQ8"/>
    <dbReference type="OMA" id="PREDFSN"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="84"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="271"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="437"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5071550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="579" mass="68329" checksum="48BF4EB19A812BD2" modified="2023-09-13" version="1">MLNSQEKQNFNKKIYKEHEEIKKLTREEVKKIREEKEIKIIKGEEKEEIKPILEFHQAPFPKGIMDKLSGRGWKEPTPIQSQGWPIALSGKDFVGIAETGSGKTLAFLLPAFVHIRENPENIPGNGPYCLILAPTRELACQIQEVSEEFGRAVRVFSSVVYGGAPRGQQIRQLRRRPDVLIATPGRLIDFVNSGHVNLNYVSYLVLDEADRMLDMGFEPQIRQILDKIPPNRQTLLWSATWPKEVQSLADQFTSNPLRVNIGSLDLSANKNVEQVIHVVEKNEKKEKFVSLLNEIYKKGKILVFVETKSYVDELCAFLKSQRFRVLGIHGDKKQSQREYVLRNFRDGHDSILIATDVASRGLDVKDIKFVINYDFPRTEEDYVHRIGRTARAGKKGIAYSFFTQESANQAKNLIKILRESEQEVNPSLFKFIKRKQNQNQNRNRNRNYNQNQNWNRNYNYNYNRNQNDNYNRNQNYNRNQNYNYNRNQNYNRNQNDNYNRNQNYNRNQNYNQNDNYNQNQNYNQNQNYNQNQNYNQNQNYNRNQNYNQNYDNFNSRRNDKNLSRKKRSSDFIDNAKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH02</accession>
    <name>A0A9Q0LH02_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH02"/>
    <dbReference type="OMA" id="DTMLLYY"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="122"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="315" mass="36865" checksum="9EEE65C720574C16" modified="2023-09-13" version="1">MNQKKQQEKLIFFDKAAFLLFKLFSLVLVLISFILIVVIIYFYFTFMLPMTASENIIIFTIQTTSAIWIIWGISYNYVKAVFTKPGYPPPNLITKEELKQLKKRYKLIKSNPHNSRALKKIPYCPICKNFKPERTHHDALSGKCVLRMDHFCPWINNTVGYKNHKFFILFMVYLILGCIYAAILSSSAFFFDIGLSDHPVDHQGPLIFVFITCLVVIIGVSFLVGFHFYLLLTNQTTIEFYQNQLPNPKSKKGKIRKFDLGKRKNFDQFFGTTNQYWFKFLFNFENPKGDGIHFIKAEKNLNYRYLNIGDSNVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH94</accession>
    <name>A0A9Q0LH94_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ndr1/hin1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH94"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="454" mass="52645" checksum="1572B8357ECB12C1" modified="2023-09-13" version="1">MIDCLLKNYDLYDSWIATIYPDGVLFKRIRFGSDNQSLVFQPEKCWIDVITLWCEFFISFFLPQISNFSKENFSLITDSNNFKKATIEFQIENNGEVSGMIVGYLSCNNSDLVINPDNPKQMNISSNSKSSLVFEVDYESSLDEDAKIECELDISQNSLPLWNITYENETVNGLIIPIYNGCLFQRADPYFPVDGISGIQVDNFDTNQESNENSFQLKFLVKINNSPVSAVFSLDCFINSSLILHETNSINFSQSEIQKYVDWIVVFESSFEYPFSIQCEIESEIEMESCWSNNSKFSNSSFDFLFQIQQDQKDSSGFWNSKLGSFLYKMGGDSKLGGVFCFIFFLLLFLTLLIFVPLFLLFKSKKKKLFQNQSKDFELKKVKNENLQKEFEMDQVVENPLKKKREKMKDLEKNADELLSQIGIEEEEKKRNKKSGLTLKEKMERDFDSIINQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHZ8</accession>
    <name>A0A9Q0LHZ8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">folate gamma-glutamyl hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:56784"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="3.4.19.9"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.9" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHZ8"/>
    <dbReference type="OMA" id="IHYHQWC"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034722">
        <property type="term" value="F:gamma-glutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046900">
        <property type="term" value="P:tetrahydrofolylpolyglutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040482293" description="folate gamma-glutamyl hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="4">
        <location>
            <begin position="64"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1 2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR615527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="308" mass="35490" checksum="CC71EA7E696FBA4E" modified="2023-09-13" version="1">MNFSFIHLIFIFLFFHLIHSQDDKRPFIIGVFTQPTSSGDESFVPWSYINFIQASGGRALPIHFNASHEEILDIMKSIDGILFTGGSQDFFPFNSTWIEAAKLIYNNAIQLNDNNHPFLLWGTCMGFELLLCLTNNDPSTITNGFDSVNVNLELIFTQFARDSNLYSKVPDTLFYNLTRFNLTYNDHHWGITPDRFNSLSNLYDFYNILSTTKDINGRSFVSSIEAKKYPFFGVQFHPEAALSLFCDSENYPHSSDAKLFAYYLSEFINSNPRNSHDIDPSILFELQGSHLLWDGNIDCMFGDYYYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIT4</accession>
    <name>A0A9Q0LIT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sesquipedalian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIT4"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="453" mass="53742" checksum="6240A3E8625A7F8E" modified="2023-09-13" version="1">MNVPEEFSGYLTKRGARVHTWRSRFFVLNQKELQYFSTKESYEKKGKKKGSIHLGYETRIGVADFEENKEKPFSFYLRKPYRTYLFFASSLDERTKWLSSIIEHINFPDQTSCEKIYEFPPLYPDPSHPFSSKDEEEYFKSLFVVGLPKDSTQEIITKYFQQSNENITNLDSKLIFKSKRNTSWVAFKFHNFQQVLKIKEFIETTPFIFNSNEFYLSALIPRCRFEDLKEIKWDASENTSENTDDIYLLSHKYNSIYRIEIDKNNSSSRDEIAKKFDVDHYYIQKIPNNQNPKNNSHEKYLVGLHFGFFPQNLKYFSLTLHCLKLGKTINLNLEIKNDEIKTSESKKEFLSKQKTKGSRFSFEDLIINSETTPPIKNVLTNTIFKIKELQSKEEDLFLLIGNEILDYNQNLPAQLNLIEAFLFQKSNDFQNENQYENQNQNENKNLDESEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ96</accession>
    <name>A0A9Q0LJ96_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease mrp protein subunit snm1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ96"/>
    <dbReference type="OMA" id="ENDIMEN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="993" mass="118156" checksum="4EBFC0AC91503C1A" modified="2023-09-13" version="1">MEIFYPKCANCNNPIKTTEVYHCLKGHSICSKCFKFGKCPKDGSSLFNTNRNHSLEKFIDELNTLMKQKLSTPNIDYEDFSVDLAKAIYYPQQKKTKKKFIEKNSFFPKRSKKFKNKPRIEIEKIEEIEEIEKGETNSTTYSSSESNPEKQKPKQNQNENQNENQNENEKPKQKQIQNQNENQNEKEKPKQKKIQIQNQNQIQIENENQNQNQNQNQNQIQIQNQIENENENQIENENENQNENENQNQNQNENQNQNKNQNQNQNQIQNQNQIQIQIQNESENENEKPKQKQIQIQIQNENEKPKQKQKQKHHKHIKKKHNHSKIGFNQKENIANQEDQLITNIPDKNTLLNFNISQQKPKRKSKRKSKRKSKRKSKRNQNENENQNQNENQNENQIENQIENQNQNQNQNENQNENQNENEIQIERKRDQILNKKKNKSKKSKNENQNQNQNQNQNQNQNENQNENEIQIERKRDQILNKKKNKSKKSKKENQIQNQIQNQNENQNENQIKIQIQNEKEKEQNTEKQKNRINRSKLLEKFAKELKNEENRDKDKDKDNTTENSQINLDEKENMSKSKKSRSKIKSKSKSKSKLQSKSKLQSKSKSKSKSKSKSKSKSKLKLKPKINYLHLNDNDNENEIDIDNEIDNDNDNENDIDNDIENKNDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNENDNDNDNDNDNDNDNDNDNDNEIDNENENENENEIDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNDLIDNDLIDNDINDNQSKNKVKHTHKSKHKRNLKKKIGQDQNLDDEELNENENKHNHKHKHKHKHKHKNKHQKKINKTKRTIINNRLNDNENDLNENDLNENDLNENDLNENDLNENDLNENDLNENDLNENDLNENDLNENGLNENGLNDNDLNDNDENENDLNENDLNENENQNQNQIEIENQIENQIQNQIENQVNEKEKKKKKKKKSKRKSKRKSKRKNGIENKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJF3</accession>
    <name>A0A9Q0LJF3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJF3"/>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="36472" checksum="4E705F5B5F9272FB" modified="2023-09-13" version="1">MNQDNQQNFQLDNKDTSKIAKILINFRKENETEKQKLDPKSKDEFVIETLVLFLDLFSKIEDIIENSLFLLQKLIITENENQKENQTLKGIDLILKSMINFPDNKEIQRQACSLLSVLSLDEQNKIEIKNLNGVELIQKVISKFPDDQILINSASKTLSNISIDNSKEKKELESLKKEYETSQTVFHFPKIQTKKKKKESTIYSSSQIYIIFFLLLLLFYLIHFLNNLEEDKGSLIHFLATKQPINFGLLKNLSEDSQVLNQQDWSPVHYLCQNESITFEIIDFLVKKGANFNLSGRVIISLINKMIIHFFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKE4</accession>
    <name>A0A9Q0LKE4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKE4"/>
    <dbReference type="OMA" id="VQTEFAQ"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="106" mass="12688" checksum="C1E9AD094778D755" modified="2023-09-13" version="1">MEQSLEEFRDLQKKINKYAQNQFEFETKINETKLVQDELKLLDDDSKIFKLIGPVLVEQSLEESQTNISKRLEFLTKEMDNLTNLIKETEQKMQDIQKKIYDSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKR5</accession>
    <name>A0A9Q0LKR5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dead/h box polypeptide 26/dice1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKR5"/>
    <dbReference type="OMA" id="LNQNHYG"/>
    <dbReference type="OrthoDB" id="9449012at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057413">
        <property type="entry name" value="Beta-barrel_INTS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051113">
        <property type="entry name" value="Integrator_subunit6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957">
        <property type="entry name" value="DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12957:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25462">
        <property type="entry name" value="Beta-barrel_INTS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 6-like beta-barrel" evidence="4">
        <location>
            <begin position="258"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="674"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="817" mass="94351" checksum="4F5491EAA895B05C" modified="2023-09-13" version="1">MLVSFIVDTSYSMLQTTSYGVSLLDCAKSAIEHIIKTRSLDPISKDDKYFLVTLESNGIKVGWQDPQVEFLEKLKYIEAKDLTDLGIGLTHSFELLNKFRLLNGVECYGEGRCLWRIQPSLIFIFTDGDNNSTLSGVSEILIHTSTEFGSNFTLEPFRWDQRVYSIVMKFPAIDSTETNLNFSSINTIEKTFTISSEEPISLMCEVTAGNCFVVRNMRQLLSCSEELVRKVFTRYASVCFESFGLNSERIKHQNALIAVNSISGSWPIPENFLITRSMMKLPSRHAQPLIKVDLNGVDLGILEKFPVDCYDIEKCLLSEELIKLNQPNLCYRVYAEGSMPINNGLGGSFGFLKQSSTNRKIKLYVLPYNYELLFSLLNRLILVQSKNQQYFNTFRKDFEMYLQSIPRYYFPYLKNALVSFGFPNIINDQTTILSDLGLSIYVTQNLQELHHQAKLENEKMQSILREKLQMRQEKNQGMHLENQKNVKKSNGFNGLGMFGTTTQPKRGANQPARLKESAVEPLVIRPFEIARDSLAAKLEEMRTKWFNLGTQPPIEPKFMIPVSEMGNYKHALLSQKFLRSVDEDEEERRKRIRTPFFGNPFKNQSTGNQNLHVDEADGNIDFESPQKRNSPSRKNSRHFGKGRKMKEIEIKNQNQNQNQNSNEIKNQDEIKNEIKNQDEIKNKIEIKIQNQNQNINQNQNQNQIQNQNQNINQNQNQIQNQNQIQNSSKIFSDLDSKDPSKHNSQILISILALIRKSNFPKTNKIDSVFEKVNMLIGKDYEKKPFLIQIAKTIQRYKEMILLQKFEEKFGNLIHGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLA7</accession>
    <name>A0A9Q0LLA7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amyloid-beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLA7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="207" mass="24334" checksum="423C2227E15D1CD9" modified="2023-09-13" version="1">MTNNYQDLSNTTYNDLESFKGNENQPNPIPDQFNSIQQDQYYTNTMGFNPYYGNNLNPNQNQNQNQNQNQNINQNQNQNQNQNQNQNQNQNQYQNQMGFNPNYGNNPTFNFNPNPISYNNPETNYTTEYQKSQQQQEALNSQYPPLVTTFSESKNQHSAPLLRNQDYIQSEAERQRTIRNRLICFRITFPIVVFLIILIIILTTAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLU0</accession>
    <name>A0A9Q0LLU0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLU0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="184" mass="22049" checksum="6ED1C516D0C33FEB" modified="2023-09-13" version="1">MSFQQFTNNSFRHNQRKNKNTKKNIKKNLKPKRTKTIQFPNQTTNQIQKPKTLDQIKMEKQEKQNQSRKRNIDNSELKKEISMQMQIQMKSPQKSSPNEQIDLQNETLSILHPDEKLLIEQKRSKFSVDSKQNAILDSQIFKHNESWKSEFETFDFSSIEEQLKENIFNFYDQLESEIMSIFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM10</accession>
    <name>A0A9Q0LM10_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM10"/>
    <dbReference type="OMA" id="YEMKNDD"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1070" mass="128627" checksum="49272C243997CC0A" modified="2023-09-13" version="1">MLYLPIFSNIRENDIEMNLISNQKIKNLFDQNIQKYFDKKLNFYENDKNDKNNKNNKNDKNNKNDKNDKNDKNDKNDKNDENDILHRNIKLFHSLNPNPNQNLNLKSIIENENQNQNQNQNQNQNQNQNQNQNEKIREFIFNPINIMKLLYIQFKLFAKLPVIFEGGNKKERLFMIKYLSEEIMKQKILIQKIKPATKPEEIINIITTAEKFVTPSSQINVFFDEINRGSKECIILLKEILLERYIKDTRISNQINLLASIKSFSVNKYNKYGSKDLNKNKYQRKEIDKNIISKLQVIPDSFFEDIYDFGKSIESEESITSLIIYKVLEKLEIFKKLKENSITKSVNLLIKRLFLFYQDYIQNENDENLNLNENENENLSIFLKIFKWILNNEIDIKLENENENQNQNQKEKENDIEYLFERITKSILISLFVVYKSKFKPKLNKQQFFQNLKEYLKKYNVGEIGEYFKKIDIQKYLDSMIENLIEKLDIKDKAEKKHIGINQRLKENIFFIFICCFSQIPLYIIGESGSSKVTSLEFILELFNQRDKENKPKFSLSLSLPHLKEFEIPSNKLIESNKIKDIFKKIKVLITFCSEIENNELIKPSVIILSNSEFQLPILHIKLKLERMETYELEQTTESILKSFSKNIADYQIKFLVKILSGIYRNESKIISKQFVQILKGRKPSNQIYGIQDYYSFIKDIGYSISNEQQKKQFSDIYFESLFKHFGIRENILNKILKRENIEEFIDIPKFDLIKLLKEISNNNDNDNLEKISRHLMIFIPDVSIFSILYENFFNNSVLIFETKKENELNFNLEKIEKCVQNGETLVIFNYQKIYNAIYDLLKQNYKTYIYSLINEKTEKINIHPNFKLIIITSKAMKYEFNQPYLLSFFEKYYFDLSYFQNLEKYLNLKQKIETELIKPIKRYKNEISNEELIIGYNENLIYSLILKYQKEEEKEKKILKLRLIKLKKIEENIKYYFTKFEREFSELFQEEIVKKKKKWIIITQYEEIDIQNIQKQNTDYSFQIEYLEKLKTKEYLIQKSKMNKNDKFVLFIDVKQNEMKSFYEMKNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMG0</accession>
    <name>A0A9Q0LMG0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein furry</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ITINVEM"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="764"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1366"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1574"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2060"/>
            <end position="2231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1899"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2060"/>
            <end position="2223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2500" mass="296583" checksum="18E321D356D5CFAA" modified="2023-09-13" version="1">MANHQKLISRDILKESMLSFCSEAHKLIDLNFSNFSNKIIDIPQVLKTQSFLLRLQPLSLLAKHDMTFTVFNLIEWRKKELEIDSTTKELTEKSSKKKSETKEMRLWTNSKKLFIDSIFAKSIQIIINQNSTYLTTEYLQDILQFSVSYIIETYEIFGTQWSHDQTIINKRFLRKLSIQILEQLCITDLDLIDSYFSLNFEIKENKIEVWIHSLGYLKLPFNSEQNAKKSLKFLQKYIDKFSQKKKNKYYINQIMAISKILYKIPNTEILELKQELSQMLTLAFVNSKKIFTKSKEEESLTNFLTQIAVFSDEIFNNHYEELLEKAIDLRNNKKTMKTGIKCLVDLGSKIISSSSDRLSAQNKIKQIIASLFHYSKPYQFNQIRDFKILDYFLKTYAKFDPNFVLENIILSLLRSEMIEKRYIGTQALYSFLRLLSSQNQNDQLTLLNSQDLFKPILPEIEKILLNYISLYGNLLSYSQTKELSDLIKENQIIETRILRNCIRCVSEILPQNIFSIISQLTLHLDGKISRSSITKLKKLLNNPDFQILLIYVYAQNLIRIPIILPEILKGLNILEVLIDEWIFIIKESKKKTGISPQLKIPSQSLISLHKDLLGEKVNVSLSDIDSSLLFFAAYPYPPIRKKTFQLLQKMDSIFQFISNPNEASSSLSQFKKFFPEIIPKCIYRTTEILSVNQLTQKTSEISITFESLFTSDDSSQTLLFLNCFSQLLPKLELDNDQFSSLFYHFFKQITTLENELNSKYQSKFNTQDSMKKIDLWHSFVSCACSIAIYDCISDDQIIELYDKVIPFSTHKKKELGLMTRNALANSNFESASLMFEKLKEHFKAIFIQSDISTKKKQIPLVNQILEIYRLFLEIHRLTPMDNDNPLIEEFSSIIMITKDYFSETADQFSLTILRLRYNYILIIQYFLDFFIKIGDNFTKSERKSFFVILKQFTGIDSRSEIPDPQSFISGFLKAEKLNQQNQEKKQNALIEQIKSINYIALKAITLLFQGEIFDSGTWRSDSQTFRWIFDLVKSQENHEFTSLFVNDILKTFYKSKSEKLFDIFYTQIYLIDENISNAFTIAFVESLLENDIEISPLFLINIILFKLNHPNPLIRQLVTSLFLKYSNKLGLKEFPKTKISSQFVTTKSKISEFQTEISDWIATQKPEMIYEIFELSFENYENLDKKTEDTSLSFQRNLREKESILNYLIPWGKQLKYNKDDEDSRLKFISLLDKLLEHTNKDLDNLTDLYDELWNSISLNDPNLDAIIDYLVGIGMGDPNTELIHTGKKIIYWITKKTGLKSFNILLSLIKFQEYHNPKIIPYKNDMIKSFIKRKFNRRRAVFRKMNESVMSSSLLFFEMGEEETKFINRKQVSLIFLCELITINVEMFYENLPLIFHVVFLELDSFVPIVLYHAKLLLVYLISYIQIENSKDLQSEETQQAFELIKEIQTQDFDMKTDEGLKRVIDLLISLFQGCANGLRNFWLDEAFKWTTQIQMYDQSNPHCISSQYFIRSHHLYRILITQVKNRDTEQIVNVLFRFLCSKSLKIKPFVNEVIETMKKISSKVVVVRNHQKLFWSSVALLNSNNVELFNYGLEILEILLKKGISGFRTLQALITTKPKDWGNSFLGIQQLVLKAFHFENLNETVFSVLSYLTLLKSDEIIENSETSLTSNIVGLLPFFCKNIHKEDENKIKWAQNIANVSQDLGFTEISEVFDQYSKGEFANMNLFLIQLRNSLTNNLLPQVNTCLLNFYLHSNYPVSEYRDEMLTIIYHLISKSEIEKEETKPNLFINLIQFTNPQNLELTKNILDLSIGENYIGKELYIERQEEIEKENVQKIEENFGNIYSSLIVLKQITNLVLDLSNLELSESPISKFENEKTKEIEYQPRFLENDFDESNQSDVEEDIIDIEDEQQEIEEQLKKQQQQKQQQQIEEIENNENNEEIEKQQQKMKILKIMKILKKLKILKILNKMNNNKSKKLKIMKILKKLKNNNKLKKMKILKKKILKLKKLKNNNKLKKMKILSKLKILNNNKSKKIEDIEQKQQIEDIKQHQIEELKIKQEEEDELRRKQEEEDELRRKQEEDDELRRKQEEEDELRRKQQEEDDELRRKQEEEDELRRKQEEEDELRRKQEEEDELRRKQEEEDELRRKQEEEDELRRKQEEEDELRRKQQEEDELRRKKEEEDELRRKQQEEDELRRKQQEEDELRRKQQEEDELRRKQEEEEEQKEIEANKEILDENLFELLDYIPISFLKPEQELKNQLLKRKTKFRKLDIHIKRTRKQWIRSLKTQKITERIAHLKIIMDALALLDGLISLYNNLLEKSQLMVQFNVVEKILHTPILTPQIYEEISYIPLFDNLKSDSCIKLKPTLKELSNQQFDDFVQKKFDMIDKFNKEHENFIKIQNQIEEQHKILETNLTFEESKVVEIKLTSLFYPFQLALFNLFRNYIHLNHEMITILNLTEEVPLQDLEKICASFSENLTYLHWVILKLKRDHLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMK2</accession>
    <name>A0A9Q0LMK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Notchless</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMK2"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="469" mass="52413" checksum="7E9B1B79D9C205CD" modified="2023-09-13" version="1">MTETIICQFQTIDNEKTGPELEIPKNITISQLQILINELLKNEEEIPYSFYVNDTEITDTLLKTMEEQKTSTEQVLTIIYQPQAIFRVRAVSRCTSSLAGHTEAILNVNFSPNGKQLASGSGDSTVRLWDLNTETPKKTLEGHSNWVLYVSFSPDGKKLASGGMSGDIIIWSVETGEKIGKTLTGHSKWITCLSWEPFHCDPTCRRLVSSSKDGTSRVWDTVNSTCDLLLSGHTKSVTCVKWGGEGFIYTSSQDCTIKVWSAKDGRLVRSLEGHGHWVNTMALNTDYIIRTGPFDHKTFQVDSLSEEESKKLAIEKYQSTKGNRTEKLVTGSDDFTLILWDPTVNNKQVARMTGHRQLINQVCFSPDMRIIASASFDKSIKLWDGNKGDFIGTLFGHVGAVYQISFSSDSRLLVSGSKDSTAKVWDIKSKKLLNDLPGHSDEVYSVDWSPDGQRVATGGKDRILKIWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMS0</accession>
    <name>A0A9Q0LMS0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMS0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="22029" checksum="88BED12B387A5618" modified="2023-09-13" version="1">MILLLIFLNWKYKKQRIPIEIELPKLRFNEDISNYHISCGYHKSFLYYSPFSSFSNLEEDLIKLFERKEFCNISFKTENGEIIKAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINSKLYFEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKKRNINFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN56</accession>
    <name>A0A9Q0LN56_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN56"/>
    <dbReference type="OrthoDB" id="6381660at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040444304" description="Fibronectin type-III domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="513"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="944" mass="104939" checksum="DF77F495C9A5267B" modified="2023-09-13" version="1">MIKLFAIILIIFLLTKQISNNYELKKVGNQWIQKQITYPNNPTNNIAFGSSISISNYVMAIGSPGNNGNDSLPGRAYVFEKQNYNLIQKAQLPNNNNQNGDLFGFSISISQDSSVIVVGVPYANVSGNVSQGKAYVFAKSESGWIITNLNASDGQTGDNFGYSVSISERVILISSPFASVNGNSEQGKVYVWEGYQDGTEWQQKLTLTATNGQANDQFGKSLSISKDSSLIVIKSQQSSSQQVTAHIFQSNGTYWNEEESFTVNGTQEYDWGGTVSISEDATTFVMGVTGDDYNQGKAYVFHYNGSNWNNQTIIPNNPSGKCCFGFSVSISQNNLLVGDPGSDSNGNTTYLFQNNGSGWNQEEQWFPQNPDEGFGQALSISEDIFAIGSPYLNYDGFDNVGGVYIYEFVYDQVNLLNCSSLFSSFDCYWNEILPITSDIEYQINYNYINNEQWEAIQSPILIDNIFFQIFNSSIYPNITGNVDYTIQIRICNSTSQICGESSDPFFLTTRIDSVKNFTVESITTTSVMISWNSPNVPVINSIPKLDHYLLFYQKQDSNETKNVSISNSSTSYELTELDSLSNYSISICGCQTDECLENYQGEIVSTTIFTKFGPVLNLQCSISNSFDISCYWNKPNDSINPSYYNFTYQAISENDNGSFDTNSTSQNFTAQYSNQIYQINVSACDSNEICGDISSIQITSRKFGPVLNLQCSISNIYFVSCYWDKPNDSINPSYYNFTYQAISENDNGSFDTNLTSQNFTAQYSNQIYQINVSACYSSEICGNISSIQITSGKFGPVLNLQCSISNIYSISCYWDKPNDSINPSYYNFSYQAISENDNGSFDTNSTSQNFTAQYSNQIYQINVSACDLNEICGDISSIQIGNQLTSSQSSNSKTVIIVCSTIIPVVVIVGIILMIVLIRKKKKKKNKEGEISMDYSVLKDEGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNC7</accession>
    <name>A0A9Q0LNC7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNC7"/>
    <dbReference type="OrthoDB" id="6157510at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="644" mass="73230" checksum="F1EF2A67EF6B9040" modified="2023-09-13" version="1">MGRNLPLKQETQNTNPLQNRTTGRIGRRSPLKQDENQNTSPTGRVGRIGRTTGRIGRRSPLKQEENKNQNPSPTGRVGRIGRRSPLKQDENQNTSPTGRVGRQYHQKKQYKQTITISPKENQKYHKRRKYHQKETISPKETISPKETISPKETNKPKETNKPTITISPKETISPKETISPKETISPKETNKPTITNGRMGRNLPLKQETQNTNPLQNRMNGRIGRRSPLKQEENQNTSPTGRVGRTTGRIGRRSPLKQDENQNQNRIGRRSPPKKESPQEEKKESDSTTSPTKSIMRRRLPRGLMGGGKTEDKQLSFNEPKETSEQEPRSIMRNRRRTMVPRAGGVKFANIEEPVETRPRTKTVTKRPQSVKMQNLGALLQGINFGGPPPPRQRQAQAKIKDVHQTDMNQAAKQKAKIQRPKIRKSQKRSTLALGSSEVDSVLQSNEFEDINLETNMSFDDFKKQVPKKITQRFTFAGEQLSQLAQNDDKKFAFKEDEEKQFEAFKDIFSSQTNSRSNLGRNDSKSNLLGRNNSRSNLGRNDSKSNFGRNDSKSNLFGENDNTKDLFGRNDSKSDLFGKNDNTKDLFGRNDSKSNLFGENDNTKDLFGRNENTSDLFGKNDNTKDLFGKNDSKSKLFDDDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP17</accession>
    <name>A0A9Q0LP17_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant sh3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP17"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903:SF8">
        <property type="entry name" value="MAX-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903">
        <property type="entry name" value="PLEKHH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="323" mass="38235" checksum="6246F078FD1E81F1" modified="2023-09-13" version="1">MNVFIRKGWMSMKQKEKQSYKRKFFILEHSTLTFYKSDKSKKPQGIIPLKSTIIKVPEDNESTEFQLITQQNNYWFMIESKKEKKDWIISLNAETEIGNENMKIEELERKIIEAERELATLQIESFLRSGNNWKNSTNFLADPFYGEFGSPINEGSTSAPLYLLLQSHNFPNQQNLSKSLPVKFNQKKRNKQSNSPLKSSSRRKPLPKNRIDQFPKNSQNNQVKNELNKNNQKINEKNQNKNENKNQNQNQNENENENENENQNRNLNQNQNENENQNQNQNENQNQNQNQNQNQNQNQNQNQNEQIEDVFGFRFTNSLKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP93</accession>
    <name>A0A9Q0LP93_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxalate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP93"/>
    <dbReference type="OrthoDB" id="10597136at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040191813" evidence="1">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="262" mass="28857" checksum="7EFAA7F00BBFFA49" modified="2023-09-13" version="1">MKLVFFFSFLFILTFFKINSLNQCSLGEFTGKAKNILFDDLVNSPEILQGQFVSFKASTGGKGSSTWLQLKKPNSELFGRNFQGINYTFAVGNVVITSQDKAFSFPTDIRSDVDVYLEGTVSNISIILPQLSPLTLIQVEVSAINFTSESQSLCQSWSNQPITQDLHKGDIHGDNVGGGLVCLDPGKTEPLHTTYHSTEVITGISGDVWLGLERGVGTYQYIHITSFFSALVPPATPHYVINNSTQQSCYIFVHSIVDSTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPW0</accession>
    <name>A0A9Q0LPW0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPW0"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="587" mass="68068" checksum="D9FAD6302387ADD3" modified="2023-09-13" version="1">MNEILFFGQNEEPKIIKNEPIKIIKPIKFKFKNENEKQIKQISTGFFSIIFLFENGKAIEYSNKNDPKQNPSKIQIEENIQKVTVGSQNEAILTLEGNVFAKGDYINSNNPKEFINISSLIEDTNDRVIQNIVSGNGSIYLLTSNQNAYGIGSNSFGQLGFDSSNFIQKPILMMKNVSKIFSGNSSQFVFLLNSNQELFGCGYNRYSQLGLGESEIEDEKLSYKPTKIQNIPKGKIIDIQSGYLHSIMLIENENENENPKRKLYSCGSDYIGLSKITHSSIFTEIKSSLFKNDNILDFSCGHSHTLILTSKGKLLAFGNNYFGQLGNKNKKIKSIPIQIKLPKLRFNGNISNYHISCGYHKSFLYYSPSYFSSSFSNLEEDLIKLFRRKEFCDILFKTKNGEIIEAHKLILKYRLNQNQNQNEIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIKITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPY1</accession>
    <name>A0A9Q0LPY1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPY1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="204" mass="24477" checksum="E734E049DF57099B" modified="2023-09-13" version="1">MSQNNLKPQLFICYKQRKKDKNKITFKCNEKEMIQSNQNQNIWIFKDESNEKTLKEWSIEMKKQKIKTKHQKRSQPIKKTFPFEKTQSNLNFFIFTEKEKKSKSQKGNENEKEIIASEFLIVLIIQFEENIFGNQNQNQNQIESESESESDIEFGNQNSNQNQIEIQSSFTQIIKVHETIMEQFLKSKIMKNILKTYFLQQFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPZ3</accession>
    <name>A0A9Q0LPZ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase ulk3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPZ3"/>
    <dbReference type="OMA" id="REHPWTT"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="361" mass="41555" checksum="2F0CB3F9A4262551" modified="2023-09-13" version="1">MEKKIIFEGNNFITTKLIGEGGFGKVYLGKTKDTNQICAIKEIDLNKNKERREKMIRELQIMKKIKHKNCIELFFIEPKDYQNVDLIYVVMEYCDLGDLNGYLRTKSSISLEEVKEIFGQIVLGLKYLSQKRIVHRDLKPKNILLQSNNNSKFGYTIKLADFGFARKIPKDDLEKSLEMEIQIGTPLYVAPEIFVNQSYSLKVDLWSLGAILYELITGNPLIQYLSIKQIMFEFQNSTNKSLPDSYLEKVPKECHDLVERLLTVDPNLRITREELYKHPFISEKLNELIGDSNTKGIDQNSKKLIGIAKIDSQSDENDDNFLSFSKGDEVEIIEIDGKMGIGKLNGKKGEIFINDFDIKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ29</accession>
    <name>A0A9Q0LQ29_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ29"/>
    <dbReference type="OMA" id="FANCHPQ"/>
    <dbReference type="OrthoDB" id="29657at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054103">
        <property type="entry name" value="CAND6-7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF2">
        <property type="entry name" value="RE59932P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21904">
        <property type="entry name" value="CAND6-7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040203346" evidence="7">
        <location>
            <begin position="19"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="CAND6/7 N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
        <location>
            <begin position="158"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5075825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="439" mass="51980" checksum="3723CB8FC4C97A91" modified="2023-09-13" version="1">MKKNLLIIFFFFISFVSCRISNFKIEDDKREGFLLKKFGFDPNGIIKFKINSLTFSRHINPHEQPNIGFIIHKFLENDLENHNMVKCPFENIRKFVIVANESEWRKGFEWKIKINESQEGEYLIWYRNCEDLSVSFDLVLTLYNEGPNYLSVGEFPLPGTYLMFFFFYFVITLFWLIYLRKNKDQKINRVHFLMTALLISKMFCVLFLSIEYFDIQKSGVPNGWNIPYYIFAFFKGVLTFIVIILIGTGWSFLKKSLSLKEKRLFAIVIPLQILDNIALVVITEQNHSSKTFYIWEIIFRLVDIICVCLILFPIIWSINHLKSVANVDKSISRILGKLKLFRLFYILTVSFIYSTRILIIFLEHLLSYKYTWIAPFFDELLTFLFFVTIGYKFRPEKANPLLKITQYGETSDENEDNLEEIDLDDFDLANQSVSIVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQE9</accession>
    <name>A0A9Q0LQE9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQE9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="323" mass="38432" checksum="7F6B43C935671EE5" modified="2023-09-13" version="1">MSNSNFGIETNFEMNSFDEESLPLPFQSDLLLSSLDFLDYAFLDSHFHSILFTNLDRNYYSNFGNNFDFDLDSLSPFSINNDFPDFFQPINQPRIFTFELDKNSFFDSPMNDNSEYQEFFSIFPNFTTNEESKLFNSNPISFQQKEQKMDLKEEEQKMDLKEEQKMDSKEEQQTSTDLKEKIEELIQNRKKKRNQTKTTFRLQCFSQISPKEFVYIRRNKKRIQIGKNFSLKKHGMEIGDKIVITSKLINLETQITKRSVDLIKRSYRNAFKPKGFIISERYSRGDLIFEFEGKPKSKTERKPKRQTKRKPKSKTKRKSNNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQL1</accession>
    <name>A0A9Q0LQL1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQL1"/>
    <dbReference type="OMA" id="ICERVIN"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="8">
        <location>
            <begin position="783"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5076885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="895" mass="102367" checksum="C380A3673737694B" modified="2023-09-13" version="1">MSRTQAEIQEIEFSLRQPKEIKRKPAIKHVISLMTAGRDVSALFSPLLSCLNTKDIEIKKLIYLYLMHYAKSKPSLVEQALQFIVVDVNDQNPLVRALALRTMASIRVEKFTTFLIEPLKEGLKDKDPYVRKTAVLAVAKLFDINPELVKKHGFVDRLTKLLSDSNSMVVSNTVATLMEISNASPEPVFQVTKENEKYITSAINESTEWGQVFLLESLMEYQPPSPKEAEKIIDRVVPRLSHKNSAVVLSSVRLILKMFTFIEEKEIILQFARKMAPSLVSLMDNNPEVQYVALRNINLFVQRFPKLLIKDAKVFFCKYKDPVYIKMEKVDILVMLATNSNINELLIEFTEYAKEVDVDFVRKSVNAIGKCAIKLSKAAQACVKVLIELVKTKINYIVQEVIIVVRDIFRRYPNQYESIIGVLCENLQSLDQPEAKASMVWIIGEYSDRIDNADELLKAFLFNFHEEDPEVQLQLLTSSVKLFLSKPDEGQEILEQVLSTATNESDNPDLRDRAFMYFRLVDAGFEEANNIILGEKPLIDTISFKYDSKLLGKLLSQISTLSSVFHKLPETFISGAKVFAQEDDDNSNDEDDGGILQVQEKEKEKKIEREKKNEMETQQIGQLINFADSQPPPIVKTKSIPQQRNDSPDQEMFEMEIAQRNDEVIVDKEEIIDEERGKGMIVSAAFRRREQQIYFDLTISNRTSYPFGKLAMVFNKNLFGMKPNAQVPITGIMPGQTTECSVVCPIIQSHKLPANEATLEVQIAIKNFEVFYTQCTSPMNIFFTEDGKIEKRNFLNHWKAISDDDERIKEIQGLSETNPDILKMKLANLNIFFIAKRQEGSIDILYFSLKLVNSVIFLIELSIDQENQSCQLATRSQDTSLIPLFEEFMERFLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQV2</accession>
    <name>A0A9Q0LQV2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQV2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="132" mass="15863" checksum="16570216FB1883DE" modified="2023-09-13" version="1">MNYWLLAYLEWTIGKQYCFKKIFYFPLYKTLICPFMGLHDYDAALNLKEILFYESHLLISSSDSRMFYRMIEMDYWIADLMILIIACGVANSRWEIIPSMKQRISFSGLFTVFDSKLPRRSRNLNQAFLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSR6</accession>
    <name>A0A9Q0LSR6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSR6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040180292" evidence="1">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="325" mass="38202" checksum="2D27E70D92B57ECE" modified="2023-09-13" version="1">MLSFLYLVIGFGIGLLLTGSNQPNSKNSFQIVPEKILIEMISVHKLEHYRPTQMTKNTPLVSFHSLSVYYNYAYAKNFGYGFLRLNIFHKRDDPNYFDPIFENDGNFQRYFDWDVFPATYYLFQKTDYDIVVYISENAIFGDFQTRIETLVEKQKSHLQNVSLIIGSKKGDLGKNLDPRMMIFFKNEKTLKFLSEWYNTPFRKEEWKEYVGVNGLEKALNEVIYPNYKNDIIVIPSVFGNGDNEGNSLMENYLLEENNLVVNQLISSLAIHLRNSYSRQIGKFQLNPEVFCPEFNSEDETEPEIKSQYEFQARLKAKFELEKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT22</accession>
    <name>A0A9Q0LT22_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein nlp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT22"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056893">
        <property type="entry name" value="UBA_Nbr1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24932">
        <property type="entry name" value="UBA_NBR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="335"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="375" mass="45474" checksum="4882123F58599436" modified="2023-09-13" version="1">MQKNNPFWIKFFFQNQIKRTKINTDFSFENLQKTISNTFQINPINYSLEFLDEEEDWIKISTEQEFYSAIQILNQNNIQIMKLKIQHENNSLKTNNSSKTQNIDHFLINFFNSLNSPFFLNLFNHFIQQFFPIIQFKFQHENLLEKMEKIILENSTSKSIENHLIIEIIKWFWTELSNCFDFKLNQIDSQKENFQKENILLNSLINFNPSLFNNEILQEKKTVPKINQIEKEFENKEQVIFQENQLEESKINPNDNFFLNLKENPQNDPKIFESQELLHFDQQIHSNLPKKLTKKEDDELFQIEEKEENELENLNEKISKKEKKAKINFEKKKFQFQQQINKLNQMGFHDRRLNYEVLKRNEGDIYRSIEELMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT25</accession>
    <name>A0A9Q0LT25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT25"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="585" mass="67924" checksum="C942742FA26E2F63" modified="2023-09-13" version="1">MNKSNYSETNTLSLNFEELLTSKNNFNDIKILVGEEEKNNYNCHKAILFFRSKFFANAFEQNPKITEISFKKINPEIMESILKYIYTGKVEINSNNIINLFGAAKFFSLDKILQWCVESISSWGESIQITSENVFLFSEFARENNFNQIEKKCFLFILDKIEDLIEKNQFYLISEQLFNDILLNSYLKISNESKLFYSVIKWGRKIRFCDISITDLALIQTLDIVPQALMLEIFQFHGFLAGNLHKQIQEIKSKYSSDVLVFQSRKIDNNFSNKNPFEKSNRKSFQNLNQNLNQNSFQNLNQNSFQNSFQNSFQDSFQNLNQNSFQKPNQKSNRISNLISFQNSIQKPNQNSNQNSFQKPIQNSNQKSNQKSNQKSNQISNQISNQISNQKSNQISNQISNQISDSIILAANQTFISKIKEWINDTNFFTNAILGFSFYRDKLPQNLHSIFDDKGKTLVIILTDKNYIFGGFTSVGWISSVGNNYITDNSAFLFTLKNPSNSPHQKFDIRKGMEQYALQYFNKDGPIFGNYEIRIKANLKSGDSNFGCAYQLPNGMKYKSKQAEEFFAGSLKKWKIKDLEIYFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTM5</accession>
    <name>A0A9Q0LTM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="TYPDNNC"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040246447" evidence="4">
        <location>
            <begin position="17"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1414"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="320"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="380"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="408"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="425"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="453"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="470"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="498"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="543"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="560"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="588"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="605"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="633"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="650"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="678"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="695"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="723"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="740"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="768"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="785"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="813"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="830"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="858"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="875"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="903"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="920"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="948"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="965"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="1038"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="1083"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="1128"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="1173"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="1355"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1473"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1497"/>
            <end position="1506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1506" mass="171305" checksum="3804904C5EC1768B" modified="2023-09-13" version="1">MFRLFFLIFLISIISTQDCDLQHDCAACLDGRSCFWCEYTQECSTTNSGFCYNGWTQNCLCEWAHDCARCTDWKCNWCEDNKTCSSTTTETCLAGWVNNKANCKCEWCEDCGWCTSQGCYWCPDNQTCADNTNLFCPNWILNLTSCDCNSRDNCDWCTTPDSDCVWCQDNKICEKNSTQSSCSSDWTRECECEWNKNCGDCTKSHGCLWCEADKTCSKDGGSICSTGWTTDCLCEWNSNCEFCLADENCLWCESNKTCSNDSNSLNCTGNWSDSCLCEWNTNCSLCTFNENCSWCQANQTCSNDTNSFNCSGDWYQECLCDWNTNCTQCISDPDRTCYWCEDNSTCSNDSNSLNCSGDWYRECLCDWNTNCTFCLLNENCYWCQDNSTCSNDTNSFDCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSSCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSTCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSTCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSTCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSTCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSTCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSSCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSTCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSSCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSSCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSSCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSTCSNDTNSFNCSHEWLKDCLCSWNTNCSSCITYPDNNCSWCQDNSTCSNDTNSFNCSHEWSKDCLCSWNSNCSSCITYPDNNCSWCQDNSSCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCSWCQDNSSCSNDTNSFNCSHEWSKDCLCSWNTNCSSCITYPDNNCYWCQDNSTCSNDTNSFNCSNEWLKDCLCSWNSNCSSCITYPDNNCYWCQYNNMCSNDTNYGHCLSEWSKECLCKWNSNCSSCITYPDNNCYWCQDRKTCSHDRHSLPCFSEWSKDCLCDWNSNCQSCINEPDNNCSWCQDDQICSNNTNSVKCSGDWNNSCLCDWNTDCDICVNDKENNCSWCQDDQICSNNTNSVKCSGDWKESCFCDWNTNCFECAVYSNCSWCWTTGTCEKNTLSICPSGWLNPFVSTSDCYCLGFSSCSSCIENNCFWCNEKEFCLSASDSHLICYDAVITDKHKCYGSYHKSKLSGGEIAIISLSSVFSIFFIIIFIIYKRRKKQKENNSNKSDLSIPLLNEKLDESTNQLIQEPIGKMFEDSNNELSVGTSDGIVEDDRDSSEKSDGLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUG4</accession>
    <name>A0A9Q0LUG4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUG4"/>
    <dbReference type="OMA" id="WNKDSTH"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="9">
        <location>
            <begin position="60"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="540"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="755" mass="87041" checksum="2869AE0A512F6771" modified="2023-09-13" version="1">MIQNQKKRKKILEKLSIIPQIKEAKLNNENLLSKKIHFENKENSNFDLSILVSINFISRNITEGSYFTFTKHHIISGNTSFAFPFPFEQFPKNEKIILKTTSNDGKFSAYFLQSKDGKYSIQIWNQHQMIHTNQVPKDLHGVVYTDDYFQCFKFSPDAKKLVYTAEAKNDEMKKSFWENDCAKTPVNDWGEDFQGKTSPCLFVYDIQENKILDIFGNLKKFEDQNNSNKSITTNKNFQVNQTNTSFGSAIWLDNDIIICCGYENEPFRLGMRFCYNRKCGIYKIQMDPNQEISEIELLTPNFFNAVSPRLNQQKTKIAFISNPNTFGTHNFAKQLCVYDLETKQTDILIDIPFKKSTDFISEDEFPGLFTNFLPQNCWISDDKKILINTTWGSSMKIIAVETQKKDYSKPEFNIISPQKDSSSWFLLDSNEKGILIYNTNPIHPFSVYFVNYQYIFKGNLKNWILVEDSSNFGNEEIKSNFENEKTKSNFGWNVFSIRPKEKENHFYESVFIFNKKEIPKRPLLVSLHGGPHSCYITEYSLFNNYFLSIGFNILCVNYRGSLGFHPEIMKSLLSKIGKQDSEDVKNAIDDLKQRKLILNESPIFIEGISFGGFITSHSVSRFPGFYKAAMVRNPVINIAAMSSNSDVPDWCLVESGLDSSHLYSYSLHDILTMSQFSPVNFVPQISSPVLVVLGCLDSRCKNSDGLQLYSSLKAYNLKTDLILYQDANHLLANLSVELDLLIRSSDWFLGYLQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUL9</accession>
    <name>A0A9Q0LUL9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5079000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUL9"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054000">
        <property type="entry name" value="MLKL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22215">
        <property type="entry name" value="MLKL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="812"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="755"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="999" mass="117458" checksum="77EA21D97354A118" modified="2023-09-13" version="1">MALEIITSIFEIGAWLKGKFDDYKDTKEEAKRLIKRIEALENPLKKIKELNSKNTNVTTLQNVLETVQGIKTLVENYEKSSKLKKFFSSKKKEFEKYDQRLDSYIGDLNMDLTILTHTDIQDLAKLFKEMRNDQQSNDAKTQKYLQNLSQEIQRNQIQTIDEPRNQIIFEYEKTNLGFIEQKFGLEKKSGEIICGIFQLKAEDPINFEKIMKEILEFSISDWNYQIKILFTSWDLDHNQFLDKEELTKAIHDFYFLITCLQSKKIVGSLQEYLINLNEEEKKKFYNVIEELVAKNEIDLKIEQIFDSLNSEANEINFSQFESYCNYPGNFVIQFLNLIKTVLNEAVGTFLITNQIETKNESSINIKKLEKFMKIPTNYENKLESNKILQDPVLVNGRIYERKYIEKIIQENPENPTIPEKNERIDPKFVLPILDLKSEIEKWKTEKISKCVTKSQKIKQSNSDIAYKILEFARKLEPENLQIINLQISLLEKELKIPEELAKQQFAKGEILFKQREYREAEQLLTKSFKLTTNPNLIENALLILKEIYSANKLTSKILETNISLSRIYLEQNPQKTKDILIQIEEGNSDQDTTTANLYLEVYSLLISAEEALGNHKETPNWYFKKANCYFMKKNYSKAIEYLNKVLEMNPDYLEALQKLAFLYNLKKDKSNECLIHIKIGQIYSKKKENDKAIEEFKKALLCDKSNSLAFNLLFEMISKQKSIFDLITLVKNYKIQDQETETFLDKISQISQIFKSQLEEESKKKDQKINQLEEEMKELKKRINETTTSILEEYEKFKKMKIQFRPFLNSEIISEKEYAQKLQEWINDNDFFSKMKKGFSAKRDGFDCKKWHSICDNKGKTLVIIKTKDNFIFGGFTQVGWTTDESKWSEEYGSYGWIKDWNAFIFSLRNDKGDRKSDKFSVQKGKEEYAVKYHQNFGPEFGNYPADFYVHGNLKTGKSDFGDSYNLPNGITYQSNEARSYLAGSYNSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUU7</accession>
    <name>A0A9Q0LUU7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000041">
        <property type="protein sequence ID" value="KAJ5079081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUU7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="223"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="447" mass="51781" checksum="CEE944E5540CEBA9" modified="2023-09-13" version="1">MSKSPNTTKSPTNTSPTRGIRGRRGPPRGRAPTRSRPMSQNIPNLRGNFRPNRITSRNPNSSLNTNQNTNTNPINKTEETNPNTKQKVANVFKSKFEEQKKIRFPQKKPIAKKQNNLPGKLNPNKLDPAKLMAQALMGSPKSIQKIHANKLKEEKKKAKKEKKIKSKEKNANENKTEKTQDQEEKLKPKKITEQEVEKMHVQTLTISTKSEETEPKQISETNKRGEDMYLLFKSEKEFLSQLETFLNNYQIPLSQSAEIANSNYAEKALVKVEPLIEQQKLIVDKLTSLMKENISINERSVGKCYSDFKTEVYEMWVDQYDEAMHNSTLLREEVAEASDLFHKCQEQCDNKNYDFFLAEPLRRINSLYQEIRTLLLHTDVEKQDYARLYNFLNKIEPVLYQTAPRLYVIEHQAELLALEETIENRGKIRIAQNGPLFAYERHCASRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV03</accession>
    <name>A0A9Q0LV03_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dc12-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_14687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000043">
        <property type="protein sequence ID" value="KAJ5079024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV03"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5079024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="647" mass="75713" checksum="CDB1766592E9DA4D" modified="2023-09-13" version="1">MCGRTAHTLTREQLIQRFQSSQFLQGERHSPSYNASPRDFLPILFNPTTMNIRSNQNLNENPNQNLNENPNQNLNENSNENLNENPNQNLNQNPNQNLNQNLNENSNQNPNQNLNQNLNENPNQNSNQIKDEKPKLLNVKKQSSQVLQDQQSQNSQQINKNRIFSSMRWGFEGSFQNLIINCRSETMTEKFTFRNLYQHNRCIIVVDGYYEWEKKGKRKIPNFIKSKNSDVLLIAGLYSSETDSSFNFVVITTKASLRLKHIHDRMPVLLDEENIDLWLDPNYDIQSDPKGLLSPLDIPLEYYQVSTHVNNIINKDKKCIEPVKSNIKPLSSYFQIATKKEQKLNENQNQNQNQNQNQLNQLNQNQNQNQLNQNQLNQNQNQNQLNQNKLNQNQNQNQNNNEQLEQKSKLSTENQKSKTSIIDSSEIPHQNLQLTHKSIKEKGISQNLITQKISVNNIVVRIEQNQLSKPKKFFNQFSEFPILSSLPNSPKKETNSKTNNLNPDTNYQNLKFKSSHSLDSIPFAINQKQNPNVTNLKNLKNQVLSNPIQKPNYENAQNYSMTEFMSQNKKPNPFLNYLRTQSKSNETIINPNQNPNQNQNFNNNQNYKPFEHFKFKKFNQLHEKRKPNSDLNSFQYSLYEKERRKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVE0</accession>
    <name>A0A9Q0LVE0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVE0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="134" mass="16172" checksum="2A1F10116EB249F2" modified="2023-09-13" version="1">MEEFFKEIGFDSKWINEKKGRKGILRDLQQLYQQETTKDFTIICEEKEIKVHKLILIMRSELFKGMFQLNVQDSSNQVHDYSQKSFQTINQLIYFLYHDKFSETQLRKEIKGELKDAKDYYQLNPHSIIDLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW72</accession>
    <name>A0A9Q0LW72_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW72"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="94" mass="11218" checksum="117A66B99B1E0163" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDTSNKVTDYSELSNKSFEIFEYWIYSNQIKDGIQITKEIINEIQTGIDYFQLNQTNPNLFDLLINKFNNQKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWS4</accession>
    <name>A0A9Q0LWS4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurofibromin-a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000047">
        <property type="protein sequence ID" value="KAJ5078725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWS4"/>
    <dbReference type="OMA" id="SCFYRSM"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="55"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="905" mass="106615" checksum="B387FE804AA8308D" modified="2023-09-13" version="1">MSRVLIEQLKNSKSIQTFSKKNVLQRSNFYNQFLSLILRNKRYIKMLSKIPDISEIDVVTRSLVFIGIQTKTLFKTIRSLIKIEFKAHHTKEQSSILRGNSLATKICSCYSQQFGNDYLLNLLGNVIVGIVTDKNLDLEIDEFSIQEKMKLEPDKIQELIKQRKSDLRCFAQAIFEKIISDESISTFPLGMRKIANIIWEFSQKYTPNQTYKLVGGYLILRFLNSAIVSPENFGLIPSEYTVTTITRNNLILISKLLQNLSNFTYFSNENITIGSDFNDFIDKNKEDFISFISKVCQPVDSFWNENDIDPDFCSERDSDVVHPNIDFLNSYNQNKANEENNQNKANEENNQNQENKENGKNEENNQNQENKENGKNEENNQNKENGKNKENKVNQNQKNNNTIQKDKNNENYQQNHIIDDLLAFEKSKFTEKYEIPLRDIFIIHRVFYENLANLKHVSPLWKNTNKTQRWEKELCLFVELFNEMGPPPLSISKPRFYPRYNYLSFHEQSLLKIYQQKNFIYYTIQNLKKESIIYIVIHRIDTSFFNDLNSLITYSIDSIRSTFNTKLSIIVDLTFSYLSISKQNYIHQALKLIKEKIEQEENSFNAKIFFFYPTFFFHFSKHWNTITCEFHDFKSKLINIYNLFEFQDFFDLNNLKLPNESQFFLPKTFSVIKVNTKGKRQKRFVKVTQNSILNIGTKNWKIKNEKQISEIHFIFVLESKIEVVLMFNQPTKEQTKQKKFLECSTDLEYRHYIFSSIEQRDCFIESVLSCGYGIHNQTKSKFKIQGIDFPKMNIFEEMSKNKKKNDSNCPLNLDRESRTVYITNDSLLIVKNSSKIETEIPFSLIKNVYLSSSICKKKSQFVGIQFEEELTAFIKVENASELVDSIMISLYKFRRDLQLISPNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWW5</accession>
    <name>A0A9Q0LWW5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000016">
        <property type="protein sequence ID" value="KAJ5080029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWW5"/>
    <dbReference type="OrthoDB" id="10029319at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="717" mass="87064" checksum="4169B8ACD435AF90" modified="2023-09-13" version="1">MFESKQENNQIQIELRHINQKFKIPNIKTISYKNAVSFCSRKLNLEENQIYFLNQNIPIKEKEIFYESINESIQKLTEQSRKICNNYYIIDVVNPDKFQEESKKQEERIRREQEQEQERIRKQKENQEIIRQKENQERIRREKEKQEQERIRREGEKQERIRRESENQEQERIRREKENQERIRREKENQERIKQKEEERIRKREKAKDLNQKTKGIAEFRLIDYDEYQKLSNLNYGGIEIKFLFKNQKYSIFQAENWLKEDSIKFCSEKFEISRSRINLVYNEFVIPNLDYLLDGINKINSFLNQTRNNRNNIISVDVIDIVDYNFIPYFINQDKIYKIEKIQLPKKNQSNCETIPIPINKSIKNQKEIKENITIKIEEDTFSETNEIQIIFMKEKNRNNHNQEIEENPMKYPFDISTKNKEQPKKPVEIIFEPKTFEIEEGNILSLFHYNEEKKEWEEEEENIFISPETGKLKVVLNHFSIHYAKEIKPPKIDLDEKLFDANWNAFWPENYNNEEIRGGMPYYVAKLFERQSLLVPDFYKYEDWCVAFHGTAYKVLDPVVGKKEGLIATDRTWGYGVYCSPSYKYASIYGIGAHFDEDQNLWVYPRHSWILNFLPDEKPDKTEITLLILQLRVKLSNFNPYPYGSNANKNDYDIFPETWQYSMFNKFKYCCNDRNFNSNEIEWRIKDPKNIKVYGILTRTIKLKELKEWIKQIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXL0</accession>
    <name>A0A9Q0LXL0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXL0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="203"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="44312" checksum="1286B592606E3626" modified="2023-09-13" version="1">MDNNNNNNQIENANQNENENEMKNLEKKVTKNLIEDYSNLLNENSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNEFLKGQNHLNKIFLNQFNKKEMESILNSISKQDFDKLKQFDFFLPNSFLINFERTIFEIQDEENQTKIKDKEKKIKRRDKRIKSFESKNQKQKQEIEKKDKENQQMKIEIEDKWKKEIEKKKPKIEIEEKWKKEKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKQNFIFGGFTQVGFNGNKGGINDSSAFIFSLRNDKGNRIPAKFTIKQNYAIYSNLSYGPTFGSGGHDIWLNSNLQPGYSNFGNSYNLPNGITYGTNEAQSYLAGSYKSWVVDEFESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXM1</accession>
    <name>A0A9Q0LXM1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine and glycine-rich protein 2 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXM1"/>
    <dbReference type="OMA" id="HASYPIK"/>
    <dbReference type="OrthoDB" id="10260249at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1264" mass="145799" checksum="86EBA16ED207302A" modified="2023-09-13" version="1">MSNWKLLLEEIKKNQQQTENKKPLINALDCLSDQIKSGEEIPNEFLESVIETLIKSLTFSNWNMNQTIFSIFCHVIIQAGKDRIVNFVSKFEKKEENSIENISKKNDILSVIFETILSDKRELRDISAQTLGSLSSVLNDQAFILVHDFLQTYSKSSNWQILEGIAMAIGYMVSRCKTISLQNFQEIFEILSSLTQFQAAANYSSYVRLAALKAFNKIIRSESIYKLQSTNQFSEFAGKIKEIFLTEINDDEINTRKQAAFLSSGLVLLQMSTLESDELKTKFVTETINELLGLANKITRWECLHGVCLSLTNLFSNQQCFLSITYDPNILKIVIETLEKFIQNQHSNEKRKNINMDTMGNSNNSALVALVNIFLGIFHLETEKNDLSKLMENLSLKESASSQFLSKHIIPQIDYLLETPFCKLIDGAESAVEILIKNAPIYMHPHISGVLVKIFKNMFHSSLPVRDAAIRAWRLGVANLKGIELIITKNSNVFDSHHLDFLLENSTEIIEKLRIDSRNNSYEVREAVYRGVAHLLSYLSNNKLFHDPNVVIKLVDILVYGSLDKTGKLSEFSRLAAIYALASFLDSSVYFDIFSSVQIFVDFVSQKIVPVIFQLLSSEEEEEIIGFSLDVVSAFSSKWSSIIQSTNTLFTPILILTNSPNENIRFHAFSSRSALVGNFSQALKQTPNFIESLINGFSGRFSLDPIDNPFEENRIAVARTISEIIVSKDFQEILFQTSSLLSKFINIIVQAYLNPENSQSKEMKMILIGIIYVVLFCLDEKSIDIIDPQIEELIDFVCSQDFWLSDSNENNENDPYANFDDDDNDNDNDNDDNDNDNDNNSTPFEQEILVVLEILLHLSNKFNNKKYSQKLSEFYTLFSKQFQKESNDNFLHQILTSKLKPNFQNINIISFIEGFITKNPSEIQPNIFQDLISIFSALQNSICDQNSSLKLTQFLLNIMEIKIQEKQFHESIIISFEIINRLLDKQIAKQIIPQIMNLFSKIKNLSESNENDDFSDEEIQDEFWIEKFGNFSFWIYCKSPFDHFSQKILLKTWELIDDTLQKKLVGFLLRKLELNQYLEKEIIDDNFQIETILEQKNFVELFQVFSLNFKNFNKDFISKLFSAIFEKKIKLINQENLEEMNVENWFEILINISRSDLKIRIEKELEFLGSLTSQKYFIEFSEGKLVVLVCLLCAEILRYSSIENDKEIVIDLIYSTLKRVFDGEDMIKFALERMCLFDKKGKVYFGIRDEKEKGKYNEGFSDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY57</accession>
    <name>A0A9Q0LY57_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY57"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69697" checksum="686820A459490783" modified="2023-09-13" version="1">MNEILFFGYNRFPTLFKNKPNTITKPIQFKFENENENENEKQIKQISITKFSTIFLFKNGKAIEYSRQNIEEIQIENIQKVSVGSENEAILTKEGNVFAKGKDINSNDPNEFINISSLIEDTNDRIIQDIVSGAQSIYLLTSNQNAYGFGSNEYGQLGFDYETLNETKKPILMMKNVSKIFSGNSSKHVFLLNSNQELFGCGTNEWGQLGLGDTEREWKIQKLTKIQNIPKGKIIDIQCGYNHSIILIENENQNENPKRKLYSCGVYYINRTDDEDENTNEFTEIKSSLFENDYIIEISVGNAHGLILTSKGKLIGFGDNEYGQLGTGDTEDKLIPIQIELPKLRFNEDISNYHISCDNFYKSFLYYSPPSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEAHKLILKYRLNQNENEIEKLKEIISKKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQILEYWIYSNQIKDEIQITQEIIDEIETGIDYFQLNQTNPNLFDLLINKFNNQNQNQNQKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY70</accession>
    <name>A0A9Q0LY70_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von willebrand factor a domain-containing protein 5a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000001">
        <property type="protein sequence ID" value="KAJ5080791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY70"/>
    <dbReference type="OMA" id="IDITEVW"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="259"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="647" mass="74544" checksum="85EA4523E09CF5A2" modified="2023-09-13" version="1">MTGLIDLKTRSQIPLKGTVIDCSIRDFTGIVSVSQRYENESNFPIETIFNFPLDSSSAICQFEVFLGEKHIIGKVKEKEKAREIYDDAIAQGHTAIKMEEEKEDIFTMNVGNLLPKTQCIVIIRYTTILKETSDKGYRFFLPTIISPRYIPQKYGETNPSYFWNLKEIPGGYTANFHIEMTSNIVSVESTTHKIYPNILGQNCEFSIKPQENESQKDLEIIIHEQDPNVPRILTEFDKDSSVSMITLFPTLSEYQNNVEIIFLVDRSGSMSGLRIQSVRETLNVFLHSLPQNSYFNIYGFGSNFEKLFDKSEKYNDATLEKAKNHAENLQADLGGTEIGNVLNEVFQTNPVDGYSRQIFLLTDGDVSNTSEVIQIVQKNSQLARVFTFGIGHGASKALVEGVARAGRGEAEFILETKDIRRKVVQQLKKAIQKTITDLEINFENLSHKPESIAPFKLPPIFANQRFLFFVFWGASLSDSFYLFSNSKVVLSGFIGNEKIQWILEMGKNKVELANKFNDVEKIPLFHILGAKLMIKDLEERTSLFHDENGELKKEFSQKDVDQKIIELAKKYNLVSSKTSFIAVVENEDVDSQKESQEMVLNQINLEMEKEKRRIEEEEKMKRMKEEEMRKRRRNEKKRRRRKKKRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZZ9</accession>
    <name>A0A9Q0LZZ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">14-3-3 protein epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000008">
        <property type="protein sequence ID" value="KAJ5080543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZZ9"/>
    <dbReference type="OMA" id="EDAHESY"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="249" mass="29034" checksum="5D339F597E93A62C" modified="2023-09-13" version="1">MDKDKKVLFMTARLGEHTERYDDVVDCMKKIADMRTELSSDERNLISLGYKNLVGARRNAWRTVIALEEKETAQEQLDIIRDYKKKIEQEIQKFCDEFLDLIDKVLLPSTTTDEGQVFFYKLKGDYLRYEAEYQENDKKQEIAKLSEEAYSKATEIAQRSLKTTNPIRLGLALNFSVFYYEILTNQDKACDIAKRAFDDAVIDLDGLSDETYADASMILQLIKENLNLWNQDFQESDDDDFDDDDDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4J9</accession>
    <name>A0A9Q0R4J9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5067014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4J9"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="321" mass="37095" checksum="5B00A034960750AA" modified="2023-09-13" version="1">MQNKKQKKKTLFTFNLTSITSFALQNINENSFEIIKFLVSKKADINAKNENQETILHLICKNINQNSFEIIQFFIEKGADINAKNNYKETPLHLICQRADINIENYYKETPLHLIGKNPNQNSFEIIQFLVSKGADINAKNNYKETLFHFICQSQNENLLEIIKYLVSKGADINAKNNYKETLLHFLFVNPNKNENLFEAIKYLVSKGADINVKNKDQETVLHYACDEKYPFEVIKFLVSKGSNANATTINNENALHLICQNENKSDSIEIIQFLIENGADVDTKNNKNKTPLYYAIRNDQKEKVAQFLLLMNNANPFDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5K0</accession>
    <name>A0A9Q0R5K0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5K0"/>
    <dbReference type="OMA" id="YSHENLQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="341" mass="40513" checksum="57F16073AB0329A3" modified="2023-09-13" version="1">MNEFGIFPQSLTDSDITRMEAMSQEYLNVMDSNRSQDFSIMGSFPSNEMSLNSFDMHQTEQIGNQNRDDTENSLEMAEDQQNSDTYQRYQQRDFRNPFNHHQLFSQQNHLNFQQQNNQNFQQQNNQNFQQQNNQNFQQQNNQNFQQQNNQNFQQQNNQNFQQKNQRLNQNFQQSNHNSNFLNQNSQVKSIQLSSNSSLGTPQSEDSFFSPTQFGQFNQLNGNEDSKLLQIKQQYVNQRNRREKLKKILSENVNLKKEVENLKSTITKLQTQITLDQQTIEKKNQEIRKYEQIVKKLSSRNQNSNQNLNQNLNQNSKKQHQVLNSNNINFFVDALQQINKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5Z2</accession>
    <name>A0A9Q0R5Z2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline- glutamic acid- and leucine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000131">
        <property type="protein sequence ID" value="KAJ5067259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5Z2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="749"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="870" mass="102768" checksum="B6DE537CAF321804" modified="2023-09-13" version="1">MSLLSIINQYLDQKENIQENISHLIQILSQNKNIFFSSNHFFIQWNSKIEEIIDKNDIFSKWSGFWLLNFTIKNSPNEIIAKNSTKWIEIFYNLLIQNRNEKSIKNQNILKKLQKNKNKNGNENKNGNEEFLIIKKLCLQTFQELICRLSEQEIKIKKNNNKNKNKNKNENQNKIKKNKNDNIFNIIQKIIHILIEDLQNFDLESINTILSLMKYKPNLLSPFYPQIERSLFEMTNLQAIEILEFSNDLNQNYFDVISDCLVNLPMCSLKASGNQPKQPNMQKDEYIAFHYGNRLPTSKKWNEILMKIIFKLNLLLNQLFRNLEEEKLPQFLNNIESYTFQENNENTRNQAKKKKDESMKEEMGMQIEIDTETKKENNENIKFEENKILEQAKFYFICINKFLTTPLNIDVLFPIEQCFALFYRILLNDGTRTKISTDEYTKSTEIKKLEIYLPSLHIWSLESMQNLISFSKGHFSSFAIFLSQSLIFSLKRTQPKTLSKNPQVIISLLNTIKSLVCEFGAGLPFSFYQEIVLIIFTHLRFILEKITINARNSQNSIQSKTEWVFKTKKRKKHNQEPVQYLSKIHHDDLVQLLSSLTNTLKMIILSYESYFPVRIQSEIDHRIATLSYLVLDLTKNNEFCSWIFSKMIEILISCLESQKPHQPAFIGIASDIFTRAFSLQLTSQESFVNDIQTQCLHGLNVCSIFLYPHSFALKGTSFGDFKSFNKEEQLHLLNFQEKDIEDFSSIQKNNSIQRDVFFFESELENLNEKIDFENLNEKIDFETNLEMNLEKKEEIKEIKKEEIKEIKEIKEIKKEIKEIKEIKEIKKEEIKKEEIEKDLISNLVEDFQEEQIDDFPEIIQSPPDSNDSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R608</accession>
    <name>A0A9Q0R608_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reticulocalbin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R608"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF86">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="283" mass="34618" checksum="0C81FA6815F73630" modified="2023-09-13" version="1">MSRCFEKFKLADKNKDGFVTIKELIEFSQMEEKKANEIMKKYDLNQNGKLDFMEFSNWILESEFEKVDENKDGKIDCEELKKYFNLNDLEVEMIFEKHDFNKDGKLDFEEYSHWRKRREMNEEFDKIDVNHDGFVEFEEIKNYYNLTNEEVQKVFDKFDVNGKKKLDFCEYRTWQRNVIFKYFFDIIDEDCDDFYLLMKNGDGKIDYEEYKVWQKELNSIKVFEKVDTDHDGLLTSQDMKDYFKLEEVEVKKIFEIFDQDKDGKLNLSEYTRWGHSHCDCRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6Z4</accession>
    <name>A0A9Q0R6Z4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6Z4"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="481"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="584" mass="68376" checksum="03C7B702192E44C7" modified="2023-09-13" version="1">MNEIIFFGKNRNSNFSKNGPYKITKPIQFKFENENENENEKQIKQISATDYATILLFENGKAIEYFNYSNPNPQKIQIENIQKVTVGFNNEAILTIEGNAFAKGDNINLEKTKEFINISSLIEDKNDRIIEDIACAAQSIYLLTSNQNVYGIGSNYNSQLGFDFRTLKETEKPILMMKNVSKIFTGIISYHVFLFNSNQELFVCGWNIHGQLGLGESNRREIKTQKLMKIQNIPKGKIIDIQCGNSHSIMLVEDEYEKRKLYSCGYHRNNGLGKNEDTYEFTEIKSSLFENDDYIVDFSCGFEQSLILTSNSKMIVFGNNEYGQLGTEKTAKYQLIPIQIELPELRFNENISNYHVLCGFDNSFLYYSPFLSNLEDDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNENEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYEFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7E3</accession>
    <name>A0A9Q0R7E3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7E3"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134:SF9">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="409" mass="45777" checksum="6F5685B13DE2436D" modified="2023-09-13" version="1">MGNNVFKSIQKGDTIKLKKLLENNKIDFQKKDSGVPVIHFTILSKKLQILQLFLSYKAPVDFPGPNGDTPLHISCKLADLEMTKTLIFSGAQTNIKNKGATPINYACSNPNCSVELLEILVSHSANVKNETRTGWQPIHSAAQICSASIIRFLIEKGADYNQKDYCGNTPLHFCCESGNVSACLELLQKGANVNSTNFDNSTPLHIACGSNSQLRLIQILISHGADVNHQDKNEWTPIHKAVIRGNFKLVELLIKSKANPNISNSDGKTPLQFAFELGKDSIGRLLEGTTRKFPLGHKKNKSLGDINLKSSSQNFVNFDFDFTLDQHKFSDLKENVSKDDFQGNIPNDHFQGNVPKDEWDLKVLNENINENINENDINENINENINEDINENIDINIDINENIEYKMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7Q4</accession>
    <name>A0A9Q0R7Q4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5068969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7Q4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="121" mass="14944" checksum="B50E172F814FC6E9" modified="2023-09-13" version="1">MEKTLENFDISLINFKKETGNGNKIHLKQRNKRNQNIAKKEKKKAKKEKKMEQKRKIKERRREFEREQEKKKMKNRIRTKGNSLRNNHPHFKFVKSQQNLKEKKQTEERSEARDERKRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R835</accession>
    <name>A0A9Q0R835_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho gtpase-activating protein 68f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R835"/>
    <dbReference type="OMA" id="NSWLENI"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="51"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="548" mass="64299" checksum="788137FA5C7E95B8" modified="2023-09-13" version="1">MKKFFRPKKKNKKQIKLEIKSQSSPPTLSNTPQKTEKTEKTQKSQNQVFGIDLETITQDQTDHVPYVVKQITKLIETEFVDCEGIFRIPGSKVQEKKVIEDVNENGELDISTCDDPYILASLLKYFFYKLPQPLLTFELFDEWNKARTVEEISNLVNQLPLVNRCTLKHLMKFCVSVSEHCKLNKMNSANLARVIGPNLFRHPINPMAFTSTIAIDNMIIHYKEIFEDNFKKEEVVQSTHSQERRSRRAIPKFFCTGVGQDQFELLQKMIEDSEKSTPDQTPKTETKETKESKQENENILETKQENENILESKQENDNILESKQENDNILESKQEIENENENQIENDNDNQLTDQNVDFSDFEEDEFFDAFVSNSDLFCQEIVDTSFLDLGLRVEVLLKKFENQELKIKDSSLLIPIQKEIKQYFSNYVQKKKQGNDIEELIKKDHLSLSESIITFQFISSIIIKNIEEYEVQENFCDSSDSDEWFSEDEQNKPINKEPELFIQKEIQMFNRLKSNIQNSSSIKIQKQFRGFLVRKEIKNIKKEFIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R884</accession>
    <name>A0A9Q0R884_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BACK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R884"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BACK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="405" mass="48114" checksum="5FBD77C5A1E24D31" modified="2023-09-13" version="1">MKEYQENKLILKDVSSSILFPILKYFYSGKIEINSENAIQILIFSSKYLIDELIEISSNFIKNNLQFETIIDILKLSESRNLNQLLDYSYQFICENFKEFIKTSFFLELEENHLNSILSNDEIFTNEFKIFQSIIKWGKHKSNINQEKENQKLDKEEKEKLQDQISNIVDKIRFIDFTKKEMQDTLKEDLIPNQISKQLIQLLIRKIEKNKEELYEFIKNEKQNQNSFIFKPRIGLKSIIIQEVEHFKKLKEWINDDEFFYKMKKGYSAKRDGFNSQNWHSKFGWTNDKSKWNEKDRGDDFGWITDPNAFIFSLRNDKNDREPEKFTIQERKEETAIRYSVKLGPSFGGGLGDIVLHSNLQPGFVNFGDTYNIYNGIREGTNQAESYLAGSFNKWIVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8G7</accession>
    <name>A0A9Q0R8G7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved serine proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8G7"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="299" mass="34034" checksum="EE10166511D9474A" modified="2023-09-13" version="1">MQAAGKLAVKVTSANGLPRSGAFYCVLSLENQEKKTNKTRGSTSNPIWNEQIHFTVTNSNSKLSVLVKLGNDTVGETTIDISELPSGNSVDKEYPLKTKGKSKSTIFLHLLYSSHQVKDVQSANIARKTFEAVSTTSDDASLKGYRLQALRQLRNARPSRKENRERAILEELTFLSEEEKIYSQKQQLESVQAITQLKETLISHLEEIIGEKVKIQDDSKDENDNDNENENENENDNENENENDNENNIEMENDIEMENENNPSIVLLMEKKNGLFFLDNSSEVHQIHKEEKRKYKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8P3</accession>
    <name>A0A9Q0R8P3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/thr protein phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8P3"/>
    <dbReference type="OMA" id="CDFERKG"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="345" mass="40474" checksum="CE9D32265782F197" modified="2023-09-13" version="1">MEIKELNFKFEDELTIQISSDLHLEFYRTFQEIPEDIIEPKAKYLLLAGDIGIPFHKMHYANFLEKMSTIFEQIFLIAGNHEYYNITFGTEKKTIKQINEIIEKICEKLKNVHFLNNKSVIFKNEKTNQIIRLIGSTLWSYIPQHAYLEVHKSMNDYCKIFIEKGKFVSANETSFMFEENLDWIKSELAKSKELNEDHVIVATHHTPLMKKTSHPKFDNDNFSSVNHAFSTNISELFKNRGSNIHTWICGHTHYCFDFVEQGTRIVGNQRGYFFESVGYDPAKTISIPSKNENQNQNQNSNENQNQNQNSNENEIQIQIENENQNQNQIENENQNSNENLNENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9R9</accession>
    <name>A0A9Q0R9R9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adaptor protein complex 1 mu subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9R9"/>
    <dbReference type="OMA" id="MIENFMP"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="173"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="437" mass="50615" checksum="3A3BAC8A4EF977CE" modified="2023-09-13" version="1">MACSGILIINPKGTILISRIYRGEFSIIKIKNFFNKIREQENESEKKPIIEDQEGTSYIFITHNSLDFVGIAKTTTNLNVGIIIEFLYKTIQVFQDYFQIVNEESITDNYVLIHQLLDEMMDFGYPQLSESSLLKEYISSEANQFVESNQKNSITTVLTSAVSWRSGNAIFKKNEVYVDVSEKLQMTISSTGRVINSEIIGSIKMFPRLTGNPTVHLGLNDKIRLSETLNSTTEKSKANPQIEFDDLKFHPCVRLKEFESSRTITFIPPDIKFELMSYRISGKVKPPFLVETMVEKHPGSRIEYLIKVKSMFNEKWEAKKVLVIIPVSEFADSPKIKTSRGKCDYRPDLNCLIWFFKIFQGKKEYTLKAHFGLSSFSKDTKTKNEKQPITIQFGMPNHILSGIRVEFLKIYEKSNYESFSWVRYITYSPEKFYEIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAI4</accession>
    <name>A0A9Q0RAI4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoporin nup35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAI4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="1" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="3">
        <location>
            <begin position="206"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="341" mass="39237" checksum="CFBB34E636C130B7" modified="2023-09-13" version="1">MQFTRQGFSHKPNELTQQHGASPQKTTYVPSFLAPFSPQVESQQKPLQQQQTPFLNKIKGNPNNKTPLHTPLDIPKTNFPTNPRPISSNRLIKSSLKKMSPPPTKSVYDEMEESNQNDFFFSNSKNSMRSTPINPMRNIHEKFMDTDDSEMNNFSPQTNFNSNLRSQNFDSFINQNENDNENDNENENDNDNTNLTQNQIYDMNQDDSDTWIVVFGINGNEIENILQFIQQFWQLEDYLPGEGNWIRIKFTNSKSAYLALQKGFLLLDSSTIIGFAPLDILSQIQQNNQPLIEPFSQQKPNHFSNNQNNQQIYKQNKTAQKKDKGKGKGIIETIADIFFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB01</accession>
    <name>A0A9Q0RB01_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ada2a-containing complex component 3 isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB01"/>
    <dbReference type="OMA" id="WDHERIQ"/>
    <dbReference type="OrthoDB" id="8197096at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="244" mass="28171" checksum="8DDDC66EB32267A6" modified="2023-09-13" version="1">MIQFLIEKGADVNAKNNKKETPLHLICQSQNPNSLKIIQFLIQKKADINAKTYDEETHLHLICKNENTNSIEIIKLLVEKGIDPNTKNCLNETSLHLICKNENTNSFEIIKFLIQQEVDINSKTIYNETPLHLFCKNSNLNPNSIEIIKLLVEKEADINIINNKKETPLHLICKNENTNSFEIIKFLIQQEVDINSKTIYNETPLHLFCKNSNLNSNSIEIIKLLVEKEADINIINNKKKHLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB06</accession>
    <name>A0A9Q0RB06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB06"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="179" mass="20672" checksum="3B2A0752A4240968" modified="2023-09-13" version="1">MNEILFFGLNKNPILFKNKPNIITKPIQFKFENENENENENENENENENENEKQIKQISSGFYSTIFLFKNGKAIEYLSQNDSNQKPEKIQIEENIQKVTAGYLNEAILTIEGNVFAKGKDINPKHPNKFINISSLIKDKNDRIIEDIVSGSSSIYLLTSNQNAYGIGDNYDWPTWIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBB7</accession>
    <name>A0A9Q0RBB7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A-type inclusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBB7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491">
        <property type="entry name" value="A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491:SF156">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="727" mass="88762" checksum="F9BD778F014F6B1C" modified="2023-09-13" version="1">MTTTSTPIFNPKQSLSEVVKIINNNFSKQNTSFNVIIISKTQEEAILQLNSKEVIIILKRNPQKIRTHKYEEIELFLDPENHNIFRIQFPDEFGYLIEAESRHNRYIICKTFGLNKYYGDLPNQIPENIDIVGAIMPVNDEIGALSNVFFEKGFVKFSVTVYFQKEMIESTLQFNLDHFKITPSKVFDSFTFFWSIHLSCSRFVSDEKILKIDINDKHISILCASSTYAELILQTFLIFNKPEQIYQQKDILPSDSPMLFSEVPTPQQIYTLLYNQSQLEKEQKHKSIKKEKKEKLKMKLIEKQQEIQDLEIDKNDSSEKQQNELEKQNELERQNELERQQELERQQELERKQELERKQELERKQELERQQELERKQELEKQKELQKQQELQRKQELQKQQELERKQNELEKQNELERQNELERQQELERQQELERQQELERKQELEKQNELERQNELQKQQELERQQELERKQELERQNELEKQNELEKQNELEKQNELERKQELERQQELERQQELQRKQELQKQQELERQKELQKKNELERKQELERQNELERQQELERQQELERQQELERQQELERQQELERQNELEKQNELEKQNELEKQQELERKQELERQQELQRQKELERQKEFVVMELDRKLNETGKKIKLNFEETLIIGTYIGLPGVNLSIPIKNTKVAHHPKKDKILRLMSRNQQFYLQYESSEDKIRFFNTFSYFFKNISLNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBI6</accession>
    <name>A0A9Q0RBI6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBI6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="110" mass="13086" checksum="30A0337027EF631B" modified="2023-09-13" version="1">MESISLISSLIFEHVLIYNLSDIIEKFNFNFRMMLSNPSTDQKTKQLLILHGLRFVEKREDLMPFKEAFKFLKNPNLLKFINEQVIVFVLFFKLNFKLNLLLCKSINIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBR4</accession>
    <name>A0A9Q0RBR4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBR4"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="298" mass="34114" checksum="F5B4A4D3F4434742" modified="2023-09-13" version="1">MVNMIHNKESIPCIIGSTIGMAGSLIFILVYLFLKEIRDSARKYIIILSICDFLLGFFAILPGPSSTGLCHTQAFFMSFLFIASCSFIFLASLVFYLKFCHDKNVDQSPIFFIWGFVLIIIVALIVSIITISFSPIASKDTHWCWVTKHKIEAIVYSIVWVTLLGTLILYSLFFFQLRGNTRISKSFQYKMFALGWIYVFTELWTSIKRARQLANENASDSSVLDFTQALFLPMLGLWDSVFFVFFDKNVRNSIKNRFSKYPKFSSNNLTGYEIFSANGDNQLQALDTSDTNDSDDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC75</accession>
    <name>A0A9Q0RC75_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC75"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="155" mass="18384" checksum="1BD82E1A1FD0DF89" modified="2023-09-13" version="1">MISRWCCIQGKFQEEPMVPFPVNLIKDRYDIKEKGNIDDIFRLIWMFFLSEFCEELITFGQIAIDLKSPESREMENWKVCVEKNNKYFIENVPVVLTLKKNASNLYRETNWVSTIGYKLNYNELLNKISKIQNQNQNQIQNQKSKSKSKSNSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDF5</accession>
    <name>A0A9Q0RDF5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysosomal thioesterase ppt2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDF5"/>
    <dbReference type="OMA" id="QRCPPAV"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098599">
        <property type="term" value="F:palmitoyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF67">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040152618" evidence="5">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="285" mass="32383" checksum="7B319FC22201590F" modified="2023-09-13" version="1">MITKFLIVLIFSSFVLADWPIVVMHGCRESAEKMAEFVGWIKAAKPDVYVLNMEIGDGLIDSLIGEMSKEVDEFNANIQADPVLSKSEKINVVGFSQGGLLCRGYIERYNSPPVANFITLATPHAGVFGIPVIDLQWLDELLKKSAYIPGVQEVFTFAQYWKDPLDYNTYLEKSIFLPDLNNEKETKNPKYRENLISLDSFTMLMATADIIVYPNESELFGFYDENLNVIPYNNTQAYKEDWLGIKTLQEEKKLYTYSVPCTHGTLRDGTCGEHAFKSYVLPHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDJ3</accession>
    <name>A0A9Q0RDJ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-related protein rab-5a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDJ3"/>
    <dbReference type="OMA" id="GGPNKTC"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="21816" checksum="5408BEABC212E59B" modified="2023-09-13" version="1">MTDIPEYKLVLLGETAVGKSSLVLRYCKDQFFDFQEPTIGAAFLTQIIKFRDSEVKLQIWDTAGQERYHSLAPMYYKGASAAVVVFDITQFKSFERSKVWISELKNNGPSNIVIALVGNKQDLEHKRVVSVQTAESFAEENNLLFLETSAKTGFQVEDLFLNITQKLPQKSNLGKGNLTFEEYDNPKVKKGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDS0</accession>
    <name>A0A9Q0RDS0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDS0"/>
    <dbReference type="OMA" id="TECKGIS"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="914" mass="105911" checksum="FD0B6598D9820A64" modified="2023-09-13" version="1">MSQTRNDQILSTAFKILQEKGETMSFKKLKQGLKQKKVSTSKIKTVEDFQNLFKKNKAIQFNPKKGFFLKISGNKNPIKENEIKSRNSRSINKKKTDSKNDSKTKSNAKVQKGSKSSHFSAAKTNEKLSNQSPLKLQNESDTTNTSYTTDTSDTSDTSDTSDTTNTSYTSDDETDTSYTSDDETEKNNFSINQNTNQNQNQIQNQNQIQIQRNTNQNQNQIQRNKGKNENENKDMNKLKSESESKSESKSESESESESESENESESESENQNQIQNQNQNLNQNLNQNQIQNQNQIKNQNQNLNQNQNLNQNQNQNQNQNLNQNLNQNKSESESETESETENESETETETETETDTGTDTESETDTESDKKQKQNKTKVNQSNSGPIRNNLNPETNIETSKLNSNLKISKNSKTKSKEPNSKKTTKDIKDETIDLKNDYHVDENSKKTQTSKEKKKEVDNQIDSETESETDTGTDTDTDTDTDTDTDTDTDNDKQLPNKTLGKSDDIRNQLNKLESQPQDKNQPKNDLKQEHLKDINSKKSKPNPKINQKSNPKPNPHQNQNQQNKNQNQNQNHQNQNQNQNQNQKRQYPNKHHSHKQTNLRQITNFFEQLLQNHGSKNLSFLQKKLIDNFGKEAHQLIKQQMGSLHEFFSKMFPFVIKSNIVSLDTECKGISSREKDQNQKIDNSSNFEKKFFEKKEVPRDQLNQIQNQNQLNQIQNQIQNQIQNQIQNENQIKNQIQIKKQKQNGKQRRKKQKQIPLENQKQTPLENQNQIPLENQKQIPLENQLNQTGEFILQTFGPLNLLNFIDIVYHLVSSNQKTTSFSREQIQSFFLSKIDKFKVIQVEERNSQVDLSLQNPHFKLWKGTYTFITLINETKFSFDQNANSNNFSIQKQIEILEAIKQIKLKELKNYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE09</accession>
    <name>A0A9Q0RE09_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_00491</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE09"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1290:FF:000002">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="12">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="215"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="11">
        <location>
            <begin position="523"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="632"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5077171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="729" mass="84315" checksum="7CACC18FDE7C180B" modified="2023-09-13" version="1">MEETKKRFLSIGLVEKEVEKILKNSSLTQTLTQVLDSANIKEGCEKSIGLMLYKVATFKFPKIPQVEERRIFVASYIGNGKIKTSPQLNEALNYLKKLGTGELKNELFEEICGVGVTITDEDVTKTVKEIISNMKPENLTLKSILAETRAKLKWAEPKVVKDEVDKQLLELQKLKDFELSSNKNLKKRDRFPRPEENTTNDPKILEKHLKETGGKVVTRFPPEPNGYLHIGHAKAMTLDFGYAEQNDGICYLRFDDTNPTAEKQEYIDGIIENVKWFGFKIYKITYSSSYFDQLYEFAIQLIKDDLAYVCHQTPKEMSQGREDMIDSPWRNRPIEESLAEFEKMKKGFYKEGEAVLRLKMNMKSENPCLRDLVAYRVKFMSHPRTGDKWCIYPSYDFTHCIVDSLENITHSLCTLEFQIRQESYYWLLDALRIYKPVVWEFGRLNLSHTIMSKRKLQQLIRENYVIGWSDPRMPTINGLRRRGYTATAIKQFCEIVGVSRKDESLIPIELLESVLIKELDKTCPRAFAILDPLKITLTNFEKFIEFEAPNHPKNPSFGKRKIPLTKVIYIEKSDFRMNDSEDFYGLSLNKEVGLKYGINITCTKVITDKDGKVIELEAEGDFKKERKPKGYIHWISPDQNEKLFTAEVHVYDHLLICEDPSTVDDWLAQINPNSLLVINDALIDPVLVNSKPGDKFQFERLGFFCVDSDSNDSKLIFNKTVPLKGKKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF17</accession>
    <name>A0A9Q0RF17_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF17"/>
    <dbReference type="OMA" id="KTHHWQI"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5078401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="184" mass="20958" checksum="FD8C4992E02AFC7C" modified="2023-09-13" version="1">MGLLTIVRKIKEKEKEMRLLMLGLDNAGKTTIIKKFLGEDISTISPTLGFNIETIEHKDYKLVFWDVGGQKTLRSYWKNYYEKTDGLIWVVDSADKRRIKDCRKELKKLLVEEKLAGASLLIFANKQDIDGSLSKLEIAKLLKIHKINGRHCEIIGCSAYNGLGLLEGIDWIVDDISSRIFANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF32</accession>
    <name>A0A9Q0RF32_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transformer-2 sex-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF32"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12417">
        <property type="entry name" value="RRM_SAFB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="399" mass="45165" checksum="59093F54C1F43D6A" modified="2023-09-13" version="1">MKIEIYLQIINIIRSPVRDHSPIREPSPYRQHSPIGLEDKGSVLYISGLKFECRINDLHHLFSKFGKIENISLVTDPRTRLSRGFGFVTMSNSEEADNCIEKLNQTTFDGKVIRVERSRREKPRTPTPGHYLGRRGRRYGAGFGGGGGRRRYYQDRPRYHDNGYHPYERRRPRSPYRKYSRSPSRSMSPPRRFNSPNEQRSKSPYLSISISISISISISKPNSISISIPNSNSISNSNSISIPNSNSVSISNLKSISNSVSNSNSNSKSNSISISISISNSKSNSVSISIPNSNSNSISNSISISNSNSIQVSISNSISISIQNQNQFPNSNSILIFISVSNSISNSISISNSNSNSKFQIQFQFQIQFQFQIQFQIQFQIQFQFQIQFQFQFQFQIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF87</accession>
    <name>A0A9Q0RF87_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sphingosine-1-phosphate phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF87"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="270" mass="31680" checksum="CFD3FC4F48C00B12" modified="2023-09-13" version="1">MGLPLRETDAKFYAPFFFGIIEICGPNFSFLTYLMICYSFFIYFIYVTGFVLLLFYRRMSNFYFIIIALSTFILNDQIIKNLVREHRPEGACTDSYGMPSGHSVSSLVFFVWFSLEILFGSRKKYENPTKAILIIILGGIFLPIPYSRVYLGYHSKLQVTIGSLCGIVYGVSFFFIFQKFHPKIFLRFKKWFNAVDDYMPELTENINVQKLDLIQDKKEEKEMEDLEDKIVDLEDNENENLNENDNLNENENLNENDNLNENDNLNENDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFB2</accession>
    <name>A0A9Q0RFB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small gtpase rac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFB2"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002060">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="22749" checksum="0DA4CBE519B691AE" modified="2023-09-13" version="1">MQKYNVSFVGYDLVGKTTLLLTYKEKKLPDGTNPFYDSNFTKKYEIENKEFEIEFWDTRIPDYDKLTPLIYIGRDVIAICFAVDNPYSFEKVKDFWIPDIEKHSPKSKRILIATKMDLRNNEKRKYELKEENKELITKEEGIELAMKIKAIKYFECSSLNQKGIETIFNEIPLVCIGKYGEQKQIEKKGCILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFD5</accession>
    <name>A0A9Q0RFD5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kicstor complex protein kaptin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFD5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029982">
        <property type="entry name" value="Kptn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435:SF2">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="397" mass="46274" checksum="2D91B6E68F93F468" modified="2023-09-13" version="1">MIEIFKTQHNGTTNIYGQTLLRNERKIYPLLASRNKILIFQFNEIKTIWESSIFFKSRYEIIAISCFKKIPYTALITSKIKKGKKEKPKFSLIILKKNLRNMEKETEQEIILSFTPIFLSSFGFDFGFDCEFFLISDDNSKIHIFEMQQNMEFHEKEIKKGFLYELTQFKSPVINLIMRELKDKRITIAGCQNGLLHLFITQIDYENEAKKETIIHESEGFLNGPVSCLQMIIPKSKKSKNISESTLNQIIEDNKEKQEKITKRIHLLISDTIESVLLLKNININGIPKFPFESSSLILKSSLFDSVTCMHLVHNPQFMKKSILFVGTFIGLFLVFQAKLSAEEWIEKKELRTNLETPIFSIRSFISKIKNQLIISVATDSRLHFFQINIISKENIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFF5</accession>
    <name>A0A9Q0RFF5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFF5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="447"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="554" mass="64633" checksum="7AFDCCBE0C666186" modified="2023-09-13" version="1">MKMKMKNEKQIKQISSGAFGTIFLFKNGKAIEYLNYLNPKLEEIQIEENIQKVVIAWQNEAILTIEGNVFAKGYNINPENPNEFINISSLIEDKNDRIIKDIVSGRDSIYLLTSNQNAYGIGSNEYGKLGFDSERLEKTEKPILMMKNVSKIFSGITSDHVFLLNSNQELFGCGDNEDKQIAVKEEINIQKLTQIQNIPKGKIIDIQCGSSHSIMLIENQNENPKRKLYSCGHYLYNGLGKDEDENTYEFTEIKSSLFDDDILDFSVGSNHTLILTSNSKLIAFGIDYHGQLGTGKTESSYIPIQIELPKLRFNENISNYHLSCGNFSSFFYYSSFSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYFEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIKITQEIIDEIQRGIDYFQLNQTNPNLFNLLINKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGE8</accession>
    <name>A0A9Q0RGE8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_14818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000051">
        <property type="protein sequence ID" value="KAJ5078673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGE8"/>
    <dbReference type="OMA" id="QSGLCVR"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5078673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="470" mass="52820" checksum="6AC071E1360AAAEF" modified="2023-09-13" version="1">MEIDSGDVIKLILQFMKENNLPKSFQAIQEETGVYLNIVNSVDKITLSIQEGKWDDVLKMLSGLTLPTDLLFDLNEQIVLELAELQELELANRITREKRRATLSHRVSSYLTEGQPSRLLVLLEQSMKFQHEHYQLSQIEGPFDLFMEKQQHKQGKTLFSPNGKYFATGSIQGFIEIWDPEIAKIHPDLAFQENGLMKHDSAILSLAFSNNSKLLASGSQNGEIKIWSIETGKLLKKIPTAHSQGITCLEILSEKLEIMSGSFDSLIRSHGLRSGNKLKEFRGHQSFVNSILIPKSGTILLSGSSDGSIRIWDIKSEQCLSIFHLPKLAQVDQEKIKGMDLNTLELQAKDDATLYSIQFIPEKKGKILVCNRSPHLFIIDQSGSISQIFSSPTIKTNQPKDFVAACVSAKGTWIYAVDESGTIFCFSLITNNLEHQFIGHEKEVVGIVHHPQKSLLVTYSEDGTIKFWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGW0</accession>
    <name>A0A9Q0RGW0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGW0"/>
    <dbReference type="OMA" id="KFGRAIN"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="126" mass="14771" checksum="84C9E9F6B1C61819" modified="2023-09-13" version="1">MKTAFDKEVDVTFEDQESINEFGKLNLRFHELKTEITNYTNELQNLDDCQTEMILFDEDQPVLVLVSDSFLSLDKQMAEELIETKIQKITKNKDTLSEELNKIEERMDVLKKLLYAKFGKSINLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHA1</accession>
    <name>A0A9Q0RHA1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000020">
        <property type="protein sequence ID" value="KAJ5079944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHA1"/>
    <dbReference type="OrthoDB" id="17995at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="734" mass="85570" checksum="540FDF437D3669EE" modified="2023-09-13" version="1">MQKEEKTLYISESIVNQIQQSENNIITITNEGFFELMKLAEDRTTRTTTIIKKAEYKGKSLKKKAEFEVNYEIKILSKNQWVCIELLSTTVALTSTTLKGPELGKGFIGIDNGKYVFITDQNGEFFLTLNFETSYVSEKARIINLLIPITEENKVEFVVPGKDVQINVLSAIDPVLKHTENAVQLNCLLPTITKLNIAWTDKDQDEEEKKEKEKELQEEMKIKEEIERRKQEKEQKRLEREKRKRERERERERARAEKEREKKKLIVNCEQFVSHSLGEGVISSLLAFKYSILHGTRSEFGVVLPKSFNVSSVDGDFIQEWKIIDASNQDLNSNENQNLNENQNLNENQNLNLNENQNENQNENQNLNLNENQNENQNLNENQNENQNLNQNQNKTKTLKVWLKMSVDSEYKLTIKGETIMESSSYQLQIPRFKNENIDREKGWIGIFAKTNIEINEMNLSNVAKIDVSELPNLVENADKETTILFAYKFLAPDFNLKLDIIKHSETEVLIAVIDEAHYIVSYSESTIKFNCVLKIKNTQKQFLHVEIPYEKYELWSTLLNSKPVKTVKNDENQIMIPLEKKDADDSGYQVELIFITEQTKIELSGKLSILFPNFDLPITHLFISLRLPSNFRYSEFSGSIQEVVDFSKQPSVFSSDSQQQKQQPQNLQSDWKIFKFERFLNVVQTPKDSLYANFVEIKKGYFEKRRIPSFKGKMIKASIFILIFAYLFFIFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHT8</accession>
    <name>A0A9Q0RHT8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHT8"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33487" checksum="31F3C155342300B8" modified="2023-09-13" version="1">MNEIIFFGSNKYPKLFKNKTNSIKKPIQFNFENENENEKQIKQISSSNFSTIFLFKNGKAIEYLKENDLNQNPEKIQIEENIQKVTVCSQNEAILTIEGNLFAKGYDINSKNYNEFINISSLIEDTNDRIIQDIASGYNSIYLLTSNQNVYGFGSNQYGQLGFDSKKLQKTEKPILMMKNVSKIFSGNTSDSVFLLNSNQELFGCGYNTYGQLGLGESKKKDKPKKLTKIQNIPKGKIIDIQCGNSQSIMLIENENENENENENPKRKLYSCGYYGYNGLGKNENIDEFTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHZ5</accession>
    <name>A0A9Q0RHZ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="1680"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="2031"/>
            <end position="2191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2125"/>
            <end position="2159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2749" mass="327802" checksum="5D3A87C4FBEAC96E" modified="2023-09-13" version="1">MEIKDFILIYISKDLSSIDPILKIDNKSYHSKFPLHGIHFFYFQSENSFSYSINNSQNIKVEMTKKQILFHFDCENLNTYLMFNAINNYISKSNQEKYKKETNKKDFDTFLQIFSAFLDEAIQKIHLENDQDQNQNQNYQFQTLDPQIISRFLFLLSSPFHENIFTQLLSQCTKETFIEINKIIHFAHKRSNNKNPYKKIYPLLQKISQTNSQIKIRFLPLFDTFSLDFTNNKSVYYFKRPKEINQDDLKICIVSFLETRKDIPQTIANFLFKLKMNSKKANWNFIHSFFENSESQLFQMKGFQELLKKITFPTLENWFEFWIGFPCFKNRNNQNQNQNKISQLAIQNLQYQPSFTEKNNKKKLDNLLQIFNSKAYKEYERQNQTLEFINYSQEQTGILYQKMLKTQNFFDQFLESGNLNLASKIQISFLTKYNTNLKNELVKPKQWEYIITQKDIIPGHEKWYKSLLLFIKFKKKYPNETNSQGQLSKFEKEFIQKLNEYYQGINQFYFIIQSKENVTLKEVEFYLHNKDSLSKFISLLSNNTKIAQFSKIFGDFRKQLPANSQNFFYEFKYGQTQNFTNLHKFNQKTIKIEEFEQFIKEIKNNEIPYHIQKYDNHFYKEILQNTISDKNNTQIKFEYICKQIKENWLKWQESISSDAIRINKIDQEIPLQHEKEFIDNLKNFDNISEKSMKQIKEFFKFRKQIIINNSFLLFCEFLLTEDQQKKEAEEFEKMKKETEKLKNKRMHKISDNFETISKQTGLKEEVLNFINELIPTDHENSLLSWIIEKAKRNFEEELIILRNHFEEKKIIKHLNDLFDFIKNINDPNNKLETIQDIKSKLQKTKLPQGIDFKYLHEKLPGIKEILNQNVSQYLIFVIKKIFEKGCKLTFDLKEPIFKCEINDTQEIKKYYDFRNMWKVSLDQNNQNPKNENANQLLTQINENSNILFQARFEEFKHLYILIDSIYQKIIKFIPIRYFKFIKQIGKPIEIKPDTIDYQAELAQFEKELFQILDDWIKNSQEISKQLLSGLFSETQYLFFFGSLINDHKQKDEDKRRHTELALRLIFGYKRSDQVKKLSKTLSEKSLSEWIPTSEAVFKEIKPSFNWESIQKAFIKIERNLLSGEFNLRTEFIKDLKQTGKKIYMVRVPNESLVLSYTALAFYLFSGSFPLREQILFCTPNTTKKDIEAFFFVHYHYNLEYLGIKAKNQTKSFFAIINPNLLSRECQELIYIKKLTQENEYKVPIINFVPEKSEVQFLDTHFNDKIIKLNFQQYEKDISAIMKKSPFYKQIHAFYSLYPGDGKTYQIRKFCHGKKEESKKYHLIQLKIGDAPELVSELNNIDAKSTNDKTERFIHIEFPNECSIEITYALWQLAMWGSIENRKFERWNHFCWNLPKNTKLLFEIPNRENLWEFFYPLKVFNLYECSSSKNDFSFHYYKISEDLHQIYKKSDNDLKKVANFLIELDKRSLLKNLKDSKKLNQKLNQIRPDPPIKEFVQISKTIFKKILKELDSDNNSQIPFTFELFSHFWKSLKAFINPIINWDIFADKYHHDKKKTYQKCEKFLNSWVISVAKYTMMPFISKNYPIFDKFEQCSLNIKFKENMPKRVSSDSIDSAKKVYGNLSKNFTEIHQFDDIFRLFSFLNPKQIPQELIGNHNAKKTKYVLTLDNISKMLFIQFRMFVGLPLILVGETGCGKTALVKYLFEDILNHKFEMITIHGGIKIKEIEELIQKAKADINNKFILFFDELNTASKAYIQLFKYMFKDRTFDNKIIPANIQLIGSINPYRKRRETDSEISNMDDFDLIDDFQEKRKEYEEIRNAVYRVHEIPNSLKQISIEFGSLNENEERKYINKMVENTFAAIFNNDENKLTHFKNKREQLEEYISKSQNFMRKNENKNLASSVSLRDVSRTLRVFRWLSESEAGQFLLKYQGQELIREIFMERALHLSLFICYASRLTQTKHQTKHQTNLTRKKYYTSIFDNEKIKASKEIIEKVEDHFIDILENKTQFKKRMIAINTPLKENCLLLFVCIFAQIPLFIIGKPGTSKSLSVELIFDAFKPPLNKNKLAMDLHLQTIRPSFLQCSAITSTRGIEEVFEIAKSKTNNEDLGVVILDEVALAELSPDLPLKVLHSKLEHLEKQLSNIIEKKGEIQEKLKELKEASVVAISNWTLDPSNTNRGILIRRDLITDLKMTATSILYTLNSEIPSNFGNKLTKIYKAIIDNQEKEQKNQQNNSQKKRSYFGLRDFYYFVKMIGYCIINHGVSTQSLDLIAISLLRNFNSKPALLQNLTIDRKIIEFKTYKTKKIISQNINGFLFKRHGFTDENDIPYFSRHMMILTKICNLRCLSDEIQKMKKYQVDFKMFIGSSLESDNSPNKIIKKLHKIEEMISKGNIIMLCKSENLYEPLYDLLNQNYQEENKVLYAKISFEHVVSDLVVHPKFRIIAISEMQRAYERESPAILSRFEKYYFNPKEFVEKKFIRKFLAEEEATIQELCKIFSIDESQLFPTFHQDLMPSLALKLQHEFINLTNNNSNNDNNNEDDKKEKFIKEYGRKRWMRICNIDEKELSEEEQLKDFYKEYKEANFSHIGNLLRFLMDQKIRRSIILTFSEMVNLINKQYEFFQLNIGEMNISDFKKKIRESLEIPDSKIIKSKSKNKSKNKSKNKSKNKSKNKNRKFFIFNFTVSEKLPEDIFYRFKYSLDSLLDNSLSQDLISNDLDYYFIFIVHLQPQQSNIPFHISFEQFWEYFFLKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI05</accession>
    <name>A0A9Q0RI05_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cilia- and flagella-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_03838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25828">
        <property type="entry name" value="CC_Cfap43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="564"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="773"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="712"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="886"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="956"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="785"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5080353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1283" mass="153989" checksum="619E13A7AE76CE6C" modified="2023-09-13" version="1">MIINDILLDEDDNLFCATSNGLFATKIIKNSEKSHVQWLSIFKNCYIDLFSSISKNSFIFLSQKHLYQIFSQNLFPIQKKDTRNRLLIDQFLVDNFPKIDLFFVSKELNSLVYLKFSQAEMQMIPLNSNFSDLKFNQNPKYHFHCIQETQIINMGKIDINNSIVICTLRELLIFPCLYLPHTQRIQIEGGLITASLISNNLLILATTNNEIIFLRLFKESSTSINYKTIFQETINSKRISDIIFLSEFSNDIYNYFVIYSSEDCGLFLLEMNQKTDYIQIRGYLDFFSLNQENRFGNEEKNAMQLFNSIQTRKDENQDLIISIPISNRSVIIPKTFPINPTKKLEVKILIQKTLNNTNLQRKFPLDSFPDRLEKLIQTNSCLSICTNYLSHEEFITALIFDDSSVFLFQSKSIEEPNITGNEEVRIYSRKFNETLSFQEKIEENLRKEQNNKISQVRNLFQQKLEELRKNYEEIILRNGKLPNDNLAKLNTEELDIDFYQKEWREAQRKQKIDEKEKQFKQKLEEKKKEWKNIKENIWEQMLVPPKILRTFSGDLKVANFSIKKQDEKEEEQEKEEQEIKRKRIQQIKSSLENRKSMNSLMRRESSKNLPQISRSNSRRTTNGRLSRSSQNFSRKQIQENEAHPFLLSYLETRRQKGESINNLLSNTQLIFYLPYELSSESVCNEQRILYRSFIREVKNKFNLEFEKALQRKIEIINLIQEKKDRMEEIEKELKNIVEKKVEFENEKRNETNSLDWDSFYITKEENFEKFIETNDPEKENENENENQNQNQKENQNQNQNQNQNQNQNQNQNQNEILQESKLALQNMMNGVLQAEVKTEEEKIQDQMQKMGIDNKPKNEMNREELLVFNEFQKKLKIISEERKKRRIFLEKAKEKMKQEIESLNEQFQKRIEDLTRFKEESLRLIYETQLMDSRLRKWNLEQEKTHKKIQTLSEFLRDLNNEKAKWIIILNDSEQEMKELNEKYQEMKEKNKKITIRFSSEFSHLEIFPKLMEQFIKKEASNHEEMNHEKNSQEFPFNEFCEFLELPKNQTEFQPENYSLFKKMKKEKKIQEEEMNEVHQKINKLKKYIGRIQREEKRIEREINKKFKKKTECEQELEFIRKNYDVLVRMDQGQIETEIEVDWDNNNDQGECVLVNRNAVDRLNNVIKNLCEKRVILLKSIFEKKEEIIQTKWKILEKEMQIDKLDLEIKDIQSIKVSKHLQTIIEDGLEGSDYQILEIQRLEKKAFHYQKVFNDKINEKKKILSSLSKKIELLKKENELLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RJ20</accession>
    <name>A0A9Q0RJ20_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RJ20"/>
    <dbReference type="OrthoDB" id="192402at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="500" mass="59509" checksum="950276D7B0DD7428" modified="2023-09-13" version="1">MNFVYYPISGFYKIEKLPKIKDKDKELPKDSEITLDDDSEMKEIDFEKESENENFSFNLPDEILMKIFKYLDFPYQLGICSCVNKQFHKISESNYLWKRMIKKHAIILDFHKLFFPYQYSINPSFDTRFGLVDYLLKKKEAKTTLFDFDQPSPYDFFTKQYYRENEESLDYYEVELVSRPLQSNHTDEEIRKVLKHPKNFFLSQRQKVYQAIQLQKKDNQMEKSKQKVSSASGVLFNPIIRLILYILAFPLTMYLTIFKADNKLDIPWIACFCPFFFVIFCFTLIAIPLTCYMTKVSRRYYEAYLFAFFLVFILLFVILLGLKLDKKPEMPLIVASIPMFLLAIFLIIFTILHHKHNSKSRDDYEIRTDFHFMVYLPIIFSTISISLLLISVYTDFEKSENFLYAGLIVLMVFDFLPMLLAIYRYPKYKRNSLDPPYFWSQILMLSLTFPSFLTELFIYLKLNNTISSKFVLISIPIQIPSIIIFIAMLADSMKELKYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L536</accession>
    <name>A0A9Q0L536_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000143">
        <property type="protein sequence ID" value="KAJ5066412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L536"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="129" mass="15593" checksum="4E0C8CE9F5461D8B" modified="2023-09-13" version="1">MRFDNDHSILTKIQEVFSSKPENQVIPFLIFIYTGMIDPISNLDLNQFQKDEWNLIESKHPFFSFYWKSNQFNFDDSDSQKLFQEYLTSSDNFSQIQNEKKIQIISQELGFDKNWIQNKKMNQELKRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5L3</accession>
    <name>A0A9Q0L5L3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_13658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5L3"/>
    <dbReference type="OMA" id="FTHITAM"/>
    <dbReference type="OrthoDB" id="294541at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF2">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="243"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="132"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="734" mass="84074" checksum="D1E0A1F17391228A" modified="2023-09-13" version="1">MDLDNVNLLDNDNDNDNDNNFDFYQQKKIQTKQRQFSSIIGYIFTINYILGVGILEIPYAFNSAGILLSSLFMCIVAIFSSITMMYLIEVESRAEAIISFYEDLTSNVDYPQIPLQSMNLMIEYSNLSLSSDLTSNENENQNQNQNQNQNQNQNQNQNENKNQNQNQNQNQNQNQNQNQNQNENQNQNQNENNQNKNQDQDESKDISEYLAQFEVSSQISEKQIQEDHSNRFFIKNRKFDTNELCKIFLGKLGKRFYTIAVTCYLYGALWSYSSVFATTLTKILPWKFLTHGVDCDIDGNLSQGCQDNYRLYLLIFTILVVPLSCRDLNEQVIIQTLLFIFRLFSLLLIFVTTIIAIYTTKGSQHKTDSPPFIATKKLFDIHGIAYVFTAAIFSQLIHHSTTIIAEPIKSKSKLRKIFNSAFATTFSFYTLLGIVCAMYFGNSTLSVISLNWISLDLFAESPKLKYAIRYLVVIFPVIEVLSAFPLHAITLGNNMFSAFYPIKKERIHFEELIQLSKRNSLQIEPKEEDISSLIITNISKRTKKKKILFRLLASFPPIIGALFLRKLPYIIIMNGSFGCFIAYIFPSLLERKSQKVSKMIFQKDSTPYSNLFSKRVFSLSSLIFGEVLPIWIVNSIIIIIIIAPSLGVASKDKDKDCSKPLWTWVLVFNICLGVTILFPIFLLNRNFYKDECGKLYSVTLGESIVIISLAGCGCLLLCLFGICWECGLKDMSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5N7</accession>
    <name>A0A9Q0L5N7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Huntingtin interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_03111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5N7"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="6">
        <location>
            <begin position="722"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="331"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="951"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="994" mass="115249" checksum="E0616ED32EA60D9C" modified="2023-09-13" version="1">MAINLKDLFLSLEGTKIRKTVIKTGEVRYCQHVPNNYSRSFHGSAVVCKPPFDPVSIEFWYKNWRIASVPCNFHAKITENTIDFIRLNGTLKKEGGRRKNVKKRWFVLNDYKLSYFQDEKHATNPIREILVSDIKNCANTADLMKIQVFTPSRTFVVTAEDPKTSFIWLKMITATQKLHEMVQTNMNIVEKALAEPENLTRYLHSDNYFIFQYLEDKSFFQYFIGKNNNIVLDLIQNELLSPTDFEQIGDYQKEAREWDPELCIALMNLAQKKSQELPINLVRFWKTKIEESDLFSINLPQFIVKDDRLMIEKLKELEQLKTDKEKTQLINQELVGKIRTYETKIQKKQKKITEIEIQNQQRQNLSSTENNELQGISKEDQLNTIKIQIEEIEEENKKSKEEKNQLNQEIKEKNQKINKLESDISKLKKELSQKKSESEQIQKNLNEKNLNSTSIIHEANFFDSKISSLETELKSVEKTISKEKKEQLEKKKSQITSTTLQNTETLRLVEENKKLLDELDQLQSKVLEMYSSFMQKNTTSQRKTSSISEEKRLPTQYLFPRNTKFSKAMLSFENALDIIQKQIQKMKQKAQTIKSHKMMRIIENLSKITKRNQIDKKEDEILKHDFVSEVLEYLKQVNDFATQTRMFSSNLWNQETRKNIDRSLEEILAPLNEILSLSRLYVSSLTKDTIPDDSKNPKIKNNFDQIFSLCQKIISKIKESRETEKVQEESKDIAVQELVTAEKSLTKASHKISEFKVKAEQLSKIKLGNYFGEDLLDLANLLIEHTSALVSDARSTQIKVSETANQNSRRSQESEKQTKEALIKGARSITQSTNLFLEILKTAVNEKKSSNKTRARIISGAKEVSAAATQLSIAANVFLPFGSNEAAILESDAKKVRNTTNELTKFAENLDHNEIFQSNIIIPTFQNPNLVKNGKTPDNLQKSEASNVFARVEAQTRVNEIEKKLQAARANLFAIRKKKYAKMHTTQVKTNRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L671</accession>
    <name>A0A9Q0L671_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nad(P)h nitroreductase ydgi-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L671"/>
    <dbReference type="OrthoDB" id="41362at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
        <property type="entry name" value="Nitroreductase/BluB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026:SF90">
        <property type="entry name" value="IODOTYROSINE DEIODINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026">
        <property type="entry name" value="NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="5">
        <location>
            <begin position="41"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="211" mass="24567" checksum="2F0A2A7D823C0F44" modified="2023-09-13" version="1">MLSNNLPSNYFSKFFNNLIYKQTTQQTKKILSEKPKKKILAFKKNQVPKKQIETIINSALLSPSSRNQQPWRAHIVRNEKLLREIGTHIYDELSPQIPRFSERKKKLKVSETVFYDAPTVIFITMDKSRVVTDRSQMDIGIFLGMLINSAQSLKIDSIPIGVILRKQDYIHKKLSFNDNEVLKVALALGYKDPERNIVEKKDFLSEIEWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6E5</accession>
    <name>A0A9Q0L6E5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparagine synthetase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_13444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6E5"/>
    <dbReference type="OMA" id="SVYESCP"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="249"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="5">
        <location>
            <begin position="570"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="707" mass="82480" checksum="184CBC06D0D59C34" modified="2023-09-13" version="1">MCGISAILRSIRIRSRIRTRNQNINQNQNQNINQNQNQNINQNINQNENQNQNQNQNQNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNENQNENINQNQNQNQNINQNINQNIQNIQNENQNINQNQNQNQNINQNQNQNENQNENQNENQNENQNENQNENEIQNENEIQNENQNQNINGNQNQNQNQNQNQNIIQNENQNIKKFLQSRGPDSFKSHQINFNQKSTLTFLASTLFIRKKVPQPLIDEQGNILIFNGEIFGTETGENINLEENDSMIFFQAITKDIEKNPLKPEILIEKIAYFHGPFSFIFYEKSQNKIWFGRDRIGRRSLLLKIEENSAIISSISDGSKSWIEIEPNFIYYIQISQEKDEYFADFYQHEYSQGFDEYFGKRSEIIPKEDPNELSEEQEKSENELIDKFIEYFKESIKKRVSNLKEPIAVLFSGGIDSMFVAAFASYFIEKEEPIYLVNVAFGEDNAPKPYNSVPDRKTALLGVKELRSFSPQTNWQFVSIDIPHSLLNKYKSHILSLISPLDSQMDFSIGAAIWFASNFDRFGSLEFPKIPKVVLVGIGADELLGGYSRHFQAYRRGSWLEIQKELEKDIQRIWIRNLSRDDRIISDSGKESRLPFLDENFIKFLNSIPLWKIVDFRKLPRGEGDKKILRIAAKKIGLKNASSLMKRAIQFGSRIAKLQGAKKGTEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7G5</accession>
    <name>A0A9Q0L7G5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7G5"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="458"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="543" mass="63474" checksum="AB4DECD1018E7D34" modified="2023-09-13" version="1">MELFPITYTGEAPDERSCARSVILSDNELLFFGGINSKCYFNTFEKFDLNTYKWIKMEIKGNQPKPRSGHSMTKVENKVYILGGMNTVGFCDNGWLDLENLTWNHFEESKIRDLDLLFHSVVVYNNQMWIFGGDQKSKFTNNLSIIDTNKNQFFIQNANVKGDIPTPRSRHSAVAWHDHMWVFGGQLYDRFHHETNDMYQLDMKDFFWKKVEQFGKVPSPRRSHFALLEGDYMYLFGGCYRREIDYCDFFRFSMISNTWEEFDLLPNHPTASNHFLVNENQNRFSLQIQQEKIVEERKANTENSPTLPHGRGGCCGKIYQRKLYLCLGGYFEADWVDISDSFYIEIETQLGFDFLNFFKRQEFVDLVLSSRNHNFTFGAHKTFVQARLGSEKMHEFLTICEYSQAYNITQNDVYSFLVALYSGSYSIDSQKMLSLLKMEKFNALEDDMQKLFEDENSKDFEIIVENQSIRVHQSIMAARSELYRGMLLVVNDDSKKSPDLSGRSAEAIRVVLRYIYTGNFGSFSDSLNSELSDCFEYYGLNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7W2</accession>
    <name>A0A9Q0L7W2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epithelial membrane protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7W2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="178" mass="19671" checksum="CB2DC146851CD232" modified="2023-09-13" version="1">MFRFLALISILACGVLSFLSWAMPYLVGVWYSGTPSFRSSFGNFQSTCTGDLCSNPMFYESRKLSDWKDADDDVYNGLCANIAMTLIGFILLVATLFLLFKKSGITHLVFVTGGIFVFIGIMAFVGKFQNSDTHDGLKTLHDLDSDFHWSYSASTAFSIIVFIVALPGAFFALKAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7W7</accession>
    <name>A0A9Q0L7W7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorting and assembly machinery component 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7W7"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="3">
        <location>
            <begin position="231"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="449" mass="52794" checksum="90F6957FC008C958" modified="2023-09-13" version="1">MEEKKLKQQIKVKKVVFSQLDENNLILKHVFNSLQNAKTLKEAIELTKEAFNILKKFYVFRNIKINFRFLENSKRKQTQNCIVEITTIQKRPFPHFSMFPSFKDSNPFFNFQLSVINILNAGIISEKFRFSNNYEELHFGISLPLIEKAKNGKFPQIHVWNSFGSNRNYFENYLKDTFTSKWIYSSDILNHFDPNSFGIGRKNGVSLWSLIFQMRQNNSWENDLSIQNLFRSTYKISLEHGYILDKRNSPQIPTKGWMFSTFNEIAGFSNFGKAHFFRNDSRFQFHIPLGKYFSYNFMSKFNFVIPTKKKKDLIIDDQIFVEDSVPFRGFNYTTLSEDIFSDFDLKKNTSGNVFGLITGTLATNFNLFRRIPLSLFTFGSVGNLGKFRRKDFTFPNLFSFAKRSRMSFGVGIATRFRDYRLEVSYSIPFRLSPQNKPQNFNPLITFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8A6</accession>
    <name>A0A9Q0L8A6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8A6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="67" mass="7902" checksum="8AFC75B0395E56D1" modified="2023-09-13" version="1">MDIWPMDYLAECISIIIDLHLLDYNRIPDTDNYRLIYQFQMTITFGHDTGQLPNTTIGIYRISFPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L948</accession>
    <name>A0A9Q0L948_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras gtpase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L948"/>
    <dbReference type="OMA" id="QHDERMP"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="214" mass="24958" checksum="EAFD38751F7350DE" modified="2023-09-13" version="1">MNRTKKTNERSDFEYHIVCFGAGGSGKSALTIMLCHNHFAEEYDPTIEDFYRKQVMVDEEICWMEILDTAGQEEYSAMRSQYYRQGEGFLLIYAINDRNSFDEVGKFQNEILRAKDSDYQPIVLVGNKADLDCERQVSFHEGQDLAKTFGCSFIETSAKTCINVEEAFFQCVREIRKFRNQFNSIDSQIQKNPNLKKSKKRVVKKKRKTRCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9D2</accession>
    <name>A0A9Q0L9D2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_13194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9D2"/>
    <dbReference type="OMA" id="IANIRWF"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="13"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="195" mass="22301" checksum="E6B10FAAF1FFB79F" modified="2023-09-13" version="1">MDPKIQSKVAHKWVIEKKIGAGSFGIIYQARNIFTHEQVAIKFENINTKHPQLIYESKIYRILSGGVGIPSVKWVGIDTRYNVMVMDLLGPSLEDLLNFCSRRFSLKTVLMIADQLLCRIEYIHSRSFIHRDIKPENFLMGTGKKGNQISVIDFGLAKKFRDARTHQHIIYRDNKKLTGTARYASVNTHLGIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAB0</accession>
    <name>A0A9Q0LAB0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lecithin-cholesterol acyltransferase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5069016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAB0"/>
    <dbReference type="OMA" id="VVNWLCY"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040487759" evidence="1">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="403" mass="45166" checksum="70ECB6E9480A10E4" modified="2023-09-13" version="1">MKVFFIFFILILILTQTQEQVQEHLDPVVIIPGLGGTKLDIKLDNAKSDYWWCRTNADWYRIWVSASEMLPEVVDCFAERLSIVYDEQTNTWSDPEGVAVKTQNGLEAISNLDPELIFMGYFKDMINKFKDHGYQEGLSIFGLPYDWRWAPGLGLTEFVQNIKTTIEYAYNLNGGKKVTVVTHSMGCCLFLDLLNSVDDAWKEQYIKGWMAISPPWGGVGQAVVALLIGYTFGIPDLLLSAKECQILERTLPAIYFFLPKQVVYGDSPIVQTPTKTYTSSMTDLHQLLNDLNLPENTHSILDLVAGASEVVSAPNVQTHIFYGTSKKTPVGVVYHDKLGGDDYSIIEVDGDNTCASSIVRKIATLWSTQQQQAITTSTFDCEHQWSPSDESVVNGVLDFVLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAY8</accession>
    <name>A0A9Q0LAY8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAY8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="110" mass="13253" checksum="88491175DD744E21" modified="2023-09-13" version="1">MFELNISDSSNQVHDYSKKTFETIQQLIYFLYHDEFEEITINQKIIEEFEDIKDYYQLNTNSIIDLYLNDEDFKRKIIQQKSFETFEIIESGNTPKNIIKSSTKNNCEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBS5</accession>
    <name>A0A9Q0LBS5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26s proteasome regulatory subunit 6b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBS5"/>
    <dbReference type="OMA" id="AIACSID"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002861">
        <property type="entry name" value="Cell division control protein 48 homolog E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasomal ATPase second OB" evidence="4">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="213" mass="24162" checksum="4D35A1753052D640" modified="2023-09-13" version="1">MEEIGIIKKKKKQEIKMKEESFEINKKQSKSQDLYEELKNLEKELNYLEIHENYIKDEHKNLKRELKRAKEEIERIRAVPLLVGQFSEMIDENTGLIGSTTGGNNMVRVLSTLDRELLKPGASVAMHKYSNAIVDILPPDADNSIQLLTAGEKPDVTYADIGGLDIQKQEIREAVELPLTHPELYSQIGIDPPRGVLLYGPPGTGKHIIQQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCH9</accession>
    <name>A0A9Q0LCH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molting protein mlt-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCH9"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="334"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="472"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="602"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="699" mass="81777" checksum="8EC1F17E8A8B54EF" modified="2023-09-13" version="1">MEKTKKKKIKNGNKKLIQNLFSACQKNSIELIEEILSKGIDINSRNYYEETPLHFVCHFPNSFETIKFLVSKGADINARNQEQETPLHIICQSQHQNSFETIKFLVSKGADVNVKNQETKTPLHFACLTLNEDCLEIIKFLVSKGVDVNVRTQHNETPLHFICYKKQNPIPIETIQFLVSKGADINVKNNDNETILHYTCQYQNQNSNEIIKYLIESGADINAINASGHSFFDILCQFENYNLFEIIKFLLSKKFDINTKNKNLQLILESVSHNQNHKLFKIIQFILSNELDVNTKNQLQEIILLYICQNKHPKSMKIIKFLVKNGADVNPNNSYGTPLQLVCQYQNENLFKIIQFLVSKGAVVNVKNKYCKSPLNLIYQYKSKNEKIFEIIQLFVNNGADPNVENYFNENLLEFVIRNGNKKLALLLLMNNANIFDVNKYLLSKEFVKKIPQIYSINEDMNNLLKSNDNFSDLIIQSNDSFKFKVHKLILLTRLNNNKTILQKFINKSKQKSKGEVENILNFLYTGFFNFDNLIQLINEFQIENENENEIRNYKIEEKEKENKITEFFKEIGFDSNWIENKKGRKGIIKDLSKLYEQNETKDFTIICEKKEIKIHKLILILRSDLFKGMFQLNIQDTSNQVHDYSGKSFKTINQLIYFLYHDNFSKENISKEYEDLKDYYQLNQNSIIDLILKGIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCM5</accession>
    <name>A0A9Q0LCM5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin subunit beta-1/Transportin-1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCM5"/>
    <dbReference type="OMA" id="NACKERQ"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="7">
        <location>
            <begin position="152"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="822" mass="95754" checksum="5A0DCAD23D4AB294" modified="2023-09-13" version="1">MIFNIDEENEDWENNFDLESSIITEFNVGENVLERMSLSFGDPVFEILKNQFQKIQNLDDWKKRSGIAIALSAIGEGCHDIMLEFLDEIANMISFSLEDSHPRVRLSACIATQRLCSDFVQTFQNNYYEDYLPKLLNLLSDSYEVIRFHTLLSLVFFCQEISQEIITPYLELFMPKFVEMIQQESVKLQEQIVSAISSFASVSKESFSQFYDSIFPFLTQVFSNATDKNYRNLRAKLIECITIIAEAVGEEIFVKDSDVVIEELLKIQSSNLEDDDPQLLHLLRGWARLASAIPNHFGTFLPSIIPFILEKATQQPQIHVISEDEINPTQQNLEIQGNTVHGILLYRNQKIQIKTAEIEEKQVAVSVINELIEQLKSNILPYSRMIVDSIMPLLNYYYDESTRTFASMCGTELVKVMMENYEEENSQKENSQKENSNLDSKLKIEINNDNNNQLIYSELSQVREEFVHQFLIELCKCLEKEKIPDVISVLIQSIGEILGYVKTTISDEFAEKLLPIIPLVIESSIKRKSKLQTIYLDEDHYHESLEKKMSDKLSTEDEISYLVVETMTQFWKFHKKVFLDFFHNNILQYYLSFLEPNTRDYDKQMAMCVFVDIVEYGGENEFLKYWNDFFYEPSMKFMLSQDQGLRQATVYCLGVCAEKLGKIFGPYCQEITQKLNSIILQKDSREESNASPTDNAICALGKICYFQRENIQYQQSLQAWLSYLPVSFDEEESPKTYDLFCKFIEEEDEVFIGENFKNLPKIISIIAQVIETQLIDDEIEERMISIISKFQNFFQEKDFQNLLFLASELSSQEEIEKLIRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCT8</accession>
    <name>A0A9Q0LCT8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitogen-activated protein kinase kinase kinase a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCT8"/>
    <dbReference type="OMA" id="THEYALM"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000071">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="130"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="699" mass="80703" checksum="C590108769C1456A" modified="2023-09-13" version="1">MGNCSRKTTNKNQQTKDEKHAKIKLSVDLDEKSTEMKELNQNQNSNQNQNSNQNQNQFQNQNSNQNQNQNQNPNQNQNPNHFQQYQNFLNQSDNSQTSLKPPLFNSNVLRNLQRVHEIENGVNKTNQISWQKGGLIGVGSFGKVFLGFNLVSGELLAVKQFPLQNSEEDNIDQLKREVELMKELKHPNIVRYVGTQIEDDCLNIFLEYVPGGSIASLLSKFGSFSQSVIQRYTVQILHGLEYLHSNNIIHRDIKGANILLDVNGQIKLADFGASRKLSEFSLKNKENYSLRGTPFWMAPEVIRTAVYGKSSDIWSLGCTIIEMLTAKHPWSEFEDQISALYHIATTKSPPKIPNEISEDCKEFLNLCLDLDPNKRPSASQLLKHQFLQFTTNQSIPSQVMDETPPPKKEIRPKSFALPRHSQLAHPLNMGQSPEYVLKTRDSIQIRDPQTRLILSLLNQKKSDGNQEAKRNQIINQQKVENQNNLFEKSGNNQSQNTILEEEKPKIKSAMINQKHATTNYKNELGYSEKGFYPLFKQNSKSHQSPNLGEKPQLKRKSVNIRSKHLMSSNTLGGKNFSPRGLTPRKHGKVQKEKLIEDFIRRKISGDFLQAQMEFEKIQTHTERHKELEKNRSKIREMRRNFEQQRRDKELKKQQNIKERLKEVLNNEEMRAEFLQKQTLDLEKSKSENSSDLESQSEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCU8</accession>
    <name>A0A9Q0LCU8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intein-containing myotubularin-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCU8"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="7">
        <location>
            <begin position="201"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="6">
        <location>
            <begin position="678"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="324"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1109" mass="130980" checksum="FDA6B72135B9770C" modified="2023-09-13" version="1">MSDKEENKEEKNNGKNKENDSKTENDIKEIIENQEDETKNQEMNLNLHQNENQQKIIYEEQTLIEGEVEITLIDKIIYIFPQDQDEKKQHFYGVLRLTNYRLYFIPTELDSIKFIPSQNFPEITLGNIASIEKFGGIKSKNILGFGFEILHKEFKKTKFYIPYKRIISKNFIESLEQLITPTKIQDTFAFSHKKQKDIDDGWQIYNPIEEFKRFEIPNDSWRISQYNDEYKLSETYPSHLIIPNDLKDEELTNIASSRFLNRIPVLVWKNNSDTVFLLRGAQSKQEKKTASYDEKYIKEIIELTKNKGDFIIIDCQNKKNTSKNKNKNKNKNNKKELTKIESDYGCKIEFLGISAKKVIEESINKLRNLCLFSSNLFKLSNENKKWYSSLEETNWINHLKTIISSSIQIGNYLNNNTSVLIQSANGRDRSVTSDTPILCRLEGDSNVFIRRIEELYNNQNEWVLNSRIKNKETCFPLNNLEVWTEDGFVKVYQIVRHKTCEEIVRVVTDSGSVDVTKGHSLLDLNGNCVKIDNVDLGHPILHHKFSSYHQKNTNSSLKISDNLNALFVNNQIAWSFGFFAAFSQCESGNNWKITHFDHNLILKFKSIFENIFINLKDKNQNIKMSKNSNQSIFKITFNIENINNRKYELSLNNPFSSNQKTLSEQFNKFLCNQFFHFSGERKIPDFVLNWNSQFQKSFFDGLVGNNLSKPKKLQNQKIKINSKSKLYISGIYLLVEEIGEMNIKIEFNEKSEEFEIEVSKKKETERNQKKPNLSSCVKQKIKIGVSNQYVYDLSTRNEHFQAGIGNIIVHNTAQLSSLTQLLEDHFYRTIRGFEILIEKEWISFGHDFGIFRNFSKKKNNEKPSYSIFIQWIDCVYQVLHQFPNAFEFNEDLLINILENLFSLKFGTFIFPFEKDRKENNIHLNTYSLWTSINENLDLFVNPMYQPVKEPLRPSVFTRHIAFWERYYMKSLFSQKIQEETKTIQRILQECSKLSQEMSLFEKENIKALEYQNRLLKELEELKKQQNDETPLNFSKNENENEKEKEKDKEKEKENENENENENDKENDKEKDKENDKENDNENDKEDDKEKDNENDKEDDKEDEKEKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE71</accession>
    <name>A0A9Q0LE71_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small rab-related gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE71"/>
    <dbReference type="OMA" id="RYFDNTF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="602" mass="70384" checksum="E5A33245D669291A" modified="2023-09-13" version="1">MNQDYDYRINILLVGYPGVGKSCLILRYFDNTFTESYITTIGVDFKIKTIEMNEKIYKFLVWDPTGSERYRQITSSYYRGAHGIMILYDVTDQDSFDNIKNWMKEIQRYAHDTVNIMLIGTKSDLVSQKVIDTETGEKLAEQLDYPFFETSSKENINVNEAFDTFFKQVGTRAVQTNDPNIKNPNKYPNQNQNQNQNQNQNSNSNSNKKYYDYRIKILLVGDYSVGKSSLVLRYFDNTFTESYVSTIGVDFKIKTMEMNEKIYKFLVWDASGGERFRQITSSYYRGTHGIMILYDVTNQESFDNIKNWIKEIQRYGNDTVNIMLIGTKSDLISKKVIDTETGEKLAEQLGYPFFETSSKENINVNEAFDTFFKQVGTRAVQTNDPNIKNPDKYPNENQNQNQKNQNSKSKYYDFLYKIAFVGDYGVGKTNLIYKFVEGTFSETPILRIPNDFPYKKLEFNEKIIKLQFWDPSGGERFRALTKYFYRGAHGIILLYDVTNQDSFDNLKYWIKKIQEYAPENINIMLIGTKSDLISQKVIDTETGEKFAEQLGYSFFETSSKENININEVFQKMIEEIEKRDKQNQNTNTNQNTNQIQNQEKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF09</accession>
    <name>A0A9Q0LF09_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein rab-37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF09"/>
    <dbReference type="OMA" id="WINEMLL"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="206" mass="23490" checksum="20FBAC4018F99AA4" modified="2023-09-13" version="1">MDNQDPNEFTLNPFKIVLLGETGVGKTLLALQFCEGISNETDPTIAVAFHTKTIEIDEKEIKIQIWDTAGQEMYRSLTPMYIRNAQAAIVVYDITNKESFEKLDSWINEMLLLASKNVLVAIVGNKIDLDQIREIPTERGEEYSQMKNFLFYETSAKTGECVNLLFLEIVKKLGGLKKQEEKKVDQNIKNLEENEKKEETKKSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFM1</accession>
    <name>A0A9Q0LFM1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sh3 domain-containing protein c23a1.17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFM1"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="383" mass="43921" checksum="C8894ECBAC0B06E9" modified="2023-09-13" version="1">MSESIFLFKVITAYKSIGDLDLTIKENEMLISFASPGGRDEWLYVIKAKDTKQQGYVPAALIDRVGDSSEVNKYKKKIDKYKSTFNFDIPLIREIISTRGVNVVKQMQNSNENKSKNDPYQKKATEQWKKAVDLFNQGNFRDSIESFKSVGRGSRVLFNIAICYISLQETRNAIFYLTEAIHSDKYFAVAYLLRGNTYFKCQDYFQAVIDYSTTITLIRDNDYIDYQPMGINYIMYRSELYFNRGFSFHKLGLTPKAIDDLTFANRIKDQKDPKQTKPQIQIPKMGPPPTGNNQIPLPNMNPIQQPPKKQAESSDIPILFQTPDAVANSELKPVERTTSRPNFRPPMRGNAMSAMLIQSLPSDPREILRRNREAKLAKRGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFX6</accession>
    <name>A0A9Q0LFX6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Guanine nucleotide-binding protein g(O) subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFX6"/>
    <dbReference type="OMA" id="TTIHSAW"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="173"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="354" mass="40696" checksum="DC60940EC59D4A34" modified="2023-09-13" version="1">MGCSNSSLTKEEKEAKKRTREIELILKRHKVKIERETKILLLGAGESGKSTIFKQMKFLQDGQFDSKDQEQVKLSIPRNCVSQMQLLVIAAEKIGIPIEHEDLASQIKKIKSCDSLTPEISKIINDLWHDPGIQQVYQFRDKKFQLNDSAEYFFTNVMRFSEENYQPTPDDILRVRVKTIGIEEAEFTVKGLHFVMVDVGGQRNERRKWIHSFEGVTSVLFCCSLIGFDQTLREDSSVNRLEEAFSIFSEICSSPWFAKASVILFLNKKDLFKKKIEENDLSIVFPEYQGGKDYQKASKFIEDKFLAISSQSNQPTRHIYAFKTCAISTKNIDRVFKCVVDTALSNVLEELDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG03</accession>
    <name>A0A9Q0LG03_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26s proteasome non-atpase regulatory subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG03"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="424" mass="47661" checksum="EAEADC68E1609E65" modified="2023-09-13" version="1">MVLEGTLICIDNSEYMRNSDFSPTRFEAQLDSVNIITGRKTNSNFENTVGVLSMGGSQPKLVIAPTSDVGKILASLHEVQIAGDSDHVTSLYIAQLALKHRMNRQQAQRIIMFVGSPVKASSEDLLRVGNMLKKNNVALDIVNFGETDSNREKLDALIETVNKNDNSHIVHIPPISGVILSDQIQGSLILGDANPSDFSNDFGVDPNIDPELALALRLSLEENARRNDSQSTPKPQSSDSNEQPQEMEDDSEYDEETRRAIEMSLAEFSGDDNSETNDDENQNQEQEQQQMQEEKQDQVNISELNEDEQMKLILERSINESQDKSNEEKDKEKQTESNQNQDNQFDSAFDLGNVLQNQDLIDSVLLSLPGVNPNDDRIKSALESLKKDGDKKDDEKKEDDKKEDDEKKDDEKNNDNQDMEIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGA0</accession>
    <name>A0A9Q0LGA0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGA0"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="236"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="341" mass="40472" checksum="5C1F9622568AE17A" modified="2023-09-13" version="1">MLIENENQNPKRKLYSCGNWQYNGLGKYETTYKFTEIKSSLFENDDNILDFSVGNYHTLILTSNSKLIGFGDNFFGELGIGDTEFQITPIQIKLPKLRFNEDISNYHISCGYSRSFLYYSPSSFSNLEEDLIKLFKRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQVFEMIYSNISKINPKLYSEIKEIINSNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGA5</accession>
    <name>A0A9Q0LGA5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyubiquitin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGA5"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="171" mass="20174" checksum="018E617B6EDA4480" modified="2023-09-13" version="1">MLLYIRTLSGQTISVEVESNETIKFLKEKIGEEKKEWDPDCLLLIFAGKLLENDKLICDYGIQKESYLHVIKFVDKIVYINIFHPIKRVLPLYRNISNSNLQIPIFENTLQNILAKISLKKYEIEGTSLIYEGKRLEYNKKLSYYQKSNENPSLDIFSLIKINIKKIKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGJ4</accession>
    <name>A0A9Q0LGJ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGJ4"/>
    <dbReference type="OrthoDB" id="20727at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="435" mass="48907" checksum="97DB99A01E2B5129" modified="2023-09-13" version="1">MSKKDIFSAIFEADLDEVRKRIKPTVFKKKGQLNKTNGDTPLHFSLYHPIRESVVRLLIQAEADVNAKNNVKKKTINKNRGRNIFNLKIILLQSTSLHFACLHKASVEIVKLLLSKGADVSLKDGNTPLHLAVSYYPIFTKNTINFDPAKLKLTTTPITKEFYTFPSIDLIQSLLDSGAEIDAKNNRTPLHFACLQKMNYSFIEFLLKSKANPNIPDLSTPFHSAIQMANQDIIDLFLQFGADPNLKDDNTPLHLACSGELSKETIEKVLKLTKDINSKNQEAPIHILCKNSSATPEIVSLFATYKADFNAKNKETPLHIAAKLQSTKSKIFEVLIENGAKVDEKNEQTPLHVACLCSATTKEALKIIIDQKKDMINAKDKSTPLHFACKFKLPLELIKILLEYGADINSKNDVKRMKTTKTKQSKIKTIKHKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGS5</accession>
    <name>A0A9Q0LGS5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Palmitoyl-protein thioesterase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGS5"/>
    <dbReference type="OMA" id="AWHTRRD"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098599">
        <property type="term" value="F:palmitoyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF67">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040185399" evidence="5">
        <location>
            <begin position="21"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="291" mass="34465" checksum="F117D204F90EA42C" modified="2023-09-13" version="1">MKNIEFFLIILTTLIIFSQEQPYPVVLMHGIGANASTMNKVVEWIHELVGPDVYVKNVEIGNGYWDSMFNKMFDMVTDFCNQLKEDQELSKYPKINLIGYSQGSLITRGYVEYCNDPPVHNFITWSGPHEGVFGIPYVDWNWLDKLLREDCYIEEVQNSITFAQYWKDTLNYDVYLNKSIFLPYLNNEEKTKDPKIKQKIQSLNSFTLLMSTVDEVVNPKESAWFAFYDDKRENIIPYNQTLAYKEDWLGLRYLDENNRLNFYKTDCRHQDYPTDKCKDVFIEYTLPRLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHC6</accession>
    <name>A0A9Q0LHC6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Major vault protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_01454</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHC6"/>
    <dbReference type="OrthoDB" id="6125719at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041134">
        <property type="entry name" value="Vault_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF3">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17794">
        <property type="entry name" value="Vault_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17795">
        <property type="entry name" value="Vault_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17796">
        <property type="entry name" value="Vault_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51224">
        <property type="entry name" value="MVP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Major vault protein repeat" evidence="11">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="113"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="117"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="173"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="11">
        <location>
            <begin position="276"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="325"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="329"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="406"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="12">
        <location>
            <begin position="481"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein shoulder" evidence="10">
        <location>
            <begin position="543"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5072439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="865" mass="97820" checksum="0240C7D03FC84163" modified="2023-09-13" version="1">MADQKSSLSLKTHQYIHILDEDTNLTHLVVGPYTYTKKQNEQIVDGPKEMLLIPPRHYCIIENPVIMKDGEPVIDTFGQAKLRYGQLEIRREGTEHFPLYPGEKLKGGITPLQIVQPDQALRLKATHDFQEEVDGKMVQRITGTEWYFLGPGTYIPNVDVEITEIVKATFIEPNTGLKIIARRTFKDGDIIRKGGETWLETTEGVYLPKVDEQVLGVVKGYVITDKKALHLRATNIFTDRFGTKRNAGDEWLVNKEQTEYYIPGVYEEVIREVPLVVLTDSQFCIVLNPVVDGKQQFGNKQLRKGPMTFFLNPGEQLEKGIQNVYVLGKNEALLLTCVESFKDEILVEEHDNENDNNENDNNEKEKETEKKKKVVTRTPGEKWMVKGPVRYIPPVEVKIIEKRVSIPLHKDEGIYVRDLHTGKIRTVIGETYMLNPHEELWQKELSEIVEKLINIDVDPTVTRGGSGIDKAQQIGRDKTRIVSFRVPQNSAVQIYDYKKKTARVQFGPDLVMLGPDEDFTVLSLSAGKPKQAHQIKAIAVLLGPDFTSDIIIVETSDHARLKLQLRYNWYFEVNKDIKEEATKIFQVPDFIGDMCKAVSSRVRGRVAATSFDDFHQRSSQLIREAVFGLDSEKKVRERLEFKANNLIVTDIDIQTVEPIDAETKSSLQKSVQLAISITTQSQEADARHEALKKATEAQGKLDEQKLEDEIEAEKTRKGLIGLQAECSAIETTGTAKAEATAKSEAGLIEGQSKVDQTNLRTKAEEIEAKIDLEYYTQKYQVEFEHQKEMNTLEVELVTQMSKIEADKFKDIVTTIGADTLESMAHSGPEVQANLLEGMNLNGYLITDGQNPIDLFKTAQGFLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI06</accession>
    <name>A0A9Q0LI06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI06"/>
    <dbReference type="OrthoDB" id="10678134at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="368" mass="43096" checksum="D7485800713EB084" modified="2023-09-13" version="1">MGNDLVSKKISKKGNKKYFKSIQESKEAVLIIDHLTLINQVNPSFIKLSGYPNDTQIIGKRISEISAAQQPHLGLRSDLAVLSVLKKILNSVSGTYQTPWFFKFPHQEKTEIIYTVWITLFSLNNKQFAQLILRKNETTTEKTAKKEDHQPSPVISLLDTHSGTTTDSTEDEDTQEADKRFEEQNQEEPEEVLNQHIELIQQKLELVKDPANQEKIRNHLKEVFDSMFDAFHYKNEQISKIKDRLDRERAEHQKKYEKLEQHLQRRLGGIKTEKNVKKTVLDENQIIKNKLTRLLLVLDRQSEVTKELYRLIEERDEKEKEDSNEDIRNIEIEMNENSNENLNENTNENTNENLNENSNENENENNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI38</accession>
    <name>A0A9Q0LI38_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the auxin efflux carrier (TC 2.A.69.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI38"/>
    <dbReference type="OMA" id="GRNPLCT"/>
    <dbReference type="OrthoDB" id="2133778at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051107">
        <property type="entry name" value="Auxin_Efflux_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752:SF18">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="515" mass="59907" checksum="A31A95D40DBD1742" modified="2023-09-13" version="1">MNNLVQNLIYIGVLILVIILFAFFSGKFNFIPTSYGPIFNALVLKALIPSLSFQAIAKENFYELNWIWFGASVLVIFLLTIISIIGTKIFQKFTLEDMIENVLGITLISYIVFGVPVMKALFGEKYLIYPVLANFTGTLFSIAFSIVILEIIELKKLQKKEENGSEISEITNQKFDQEIEIENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENENQNQNQIQNLNKNQFENQNQNQNQNQNQNQIQNQIQIQNQNLNQNQIQIQNQIQNINQNQNLYEFEYQMKNQRFEEIELTSQGFETLDMSEKLYSHIFGDEIELPTFVSYFEPTLHKKYNRKQFIKSLLRRIFLNPLIVAMLLGIIYSLTGLEVPTLLNNILESLSGTVFPLALISLGLFAAERKIIDCSWKQLIFYYFMRMIFSPAVALLVAFILDIKGKEGQILVITFCLPISLFPYIVALRYNLSTGIYSTQSIIQNFLMIPSFFLWFAILRSIPFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI46</accession>
    <name>A0A9Q0LI46_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08934</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI46"/>
    <dbReference type="OMA" id="CMREGNK"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="151"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="283" mass="31859" checksum="59741C08E8032A71" modified="2023-09-13" version="1">MSTVPSLNLSGKKKKSRKPKSKTNTNQPKKTTKSPTQANPVTPPPDITLSLPARKKKSSKSKGKSKSDSNKTQKQNLNGNKNNAKNPIEKDKEVEAEPSISPVPNDPPENLKKILENLEQLKSEPEYTYDDLLSRIFSKLKENHPRFLGESRQFVMPPPDVGKLGGKKVVLFNALELCNIMRRPPEHVLSFFFAELGTTGSIDGDGRFIIKGRYQAKHIESVLRSYINQYVRCSVCGRYQTSLVHNNRLYFIKCDSCEAQKTVVQIKSTQHAPAEKKKNLKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIQ7</accession>
    <name>A0A9Q0LIQ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIQ7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5072173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="168" mass="19541" checksum="3D8F90C9F9527941" modified="2023-09-13" version="1">MKSYKRVSRISSFSNEFFQDGNQLQTPRKRVCDDIQEQESQIQIEFEPKSRFKSKNIHNYDYGNNFENIKSIRITKPKANTNTNININTNSNTNTNTNLNLNINSNLNSNLNINTNSNYNSNYNPNSNYNFIANKISKSNCNLDLNLEFSPNIKKPLLFNKTPLFLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ67</accession>
    <name>A0A9Q0LJ67_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ67"/>
    <dbReference type="OMA" id="NTFRECK"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="369" mass="43562" checksum="6CCB51E5A105CDD6" modified="2023-09-13" version="1">MKKSTKKFLDWKKIIPKSQENPIGVAKSGIYFDSELNKIYIFGGSELDSTKEAKLMNQFFSFDLQEQIWEKIEPTSKKSPKPRSALSMCGFKNKMWIFGGHFESKFYNDLWEFNSQTNEWKKIKTDNNESQPEPRYSHSIIYHNAYIYVFGGVLSDGSRKNDVWKFNTLEPKWEIIKTKGKIPDPRSSHTCHIYEDNLLIFGGLDKSVVKSMEIFLLDLKLFEWKQIHPILDIPAIGGHISMIYENQYLVCFGGFSWHSRYSNKLSYYDLKSNEWFLYQYYQNQLEKNLKEKNQKEKNLKENQLEKTKNSVPSPRFGSVGCHISRSSFFVFGGQYENSISYDEIWIFSFEHELVCDFRNFLELKVLVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJC5</accession>
    <name>A0A9Q0LJC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basic leucine zipper 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJC5"/>
    <dbReference type="OrthoDB" id="551672at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="108"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="179" mass="21622" checksum="3237D43039C61181" modified="2023-09-13" version="1">MKSTQTEFELNFPNSLFEEDNPNDFNTELLSFQQNQNENDIDDIDDIFEGNDLNFFEENQFLDQNKKEEITPRKNQKILKPLQKKDSKPQIDLAGKMSREQLKKLSPDQKKMRRLLKNRKSAKKSRERIRKRLTDFEEETKRLKLENFEIREKLEFFVTENSHLKKQIQILTNNLKQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJE7</accession>
    <name>A0A9Q0LJE7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJE7"/>
    <dbReference type="OrthoDB" id="10677189at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="327" mass="38495" checksum="CE206D8CEE275118" modified="2023-09-13" version="1">MKEIITLEMKSNETKETINWENFEKLLKTIENHLKIEKSFDYLGIGQKLLEKLKEITLSLFDYFNKEEINKIVIERNYGFGEEWSKSIDLSFESGANFGNSIAIPIAYEFKPFLIDFWDKELASKPGRIFRDYMFRTYLAIPHEFVHCLQSKTKQLDKSPQNWIAEHDACYLGVAFLNWMHKNLPVETKNQLFPIDGFFEELILYSLDLAVGLFNNFGNNNTDFLYKNWRDSFGFDYPNDDDPNVVEGVPFYFKSRLGIEAFFDETNLFQTQINICFKNRTGVLQEQKMNIPKEILIDSSKSDLPILISSLKEEELKDFYKQIKNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJR6</accession>
    <name>A0A9Q0LJR6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJR6"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="140"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="193"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="262"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="404"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="477" mass="56511" checksum="6AE28791564AD7DC" modified="2023-09-13" version="1">MQIFVKTLTGKTITIEIDPTDTIEFLKYKIYEREEIPICVQRLIFAGKHLENEKTLKHYNIQKESTIQLLIGLTELPNSSTGIKTSDGQFISIENACPHLYLDYDLKDFSFPIFIKSSNNKIFKVFLLNSQNLPNIQFNHLKQKIESITKIPKNEQKLFYKDVELKDDKSLSDYDISKDSIIDLKNKFRKQKLGLKVVALDQTMQIIEFSPFCKIKKIREELKAQKYLFWNKSLFFGKFILEDKKTIFDYGIENGDTIYLFMKIFIEISPKKRIEIEFEFETNLTIKNIKELFQQKMKEELINQDFFIIFNNQTLQDNQKLNECGIRNQSILSYLIKINIQALDGKINELFISPYLTINEFLNELYLKGISEKNIQFNDKLITNFQKEQKINECGIENQSILSYLITIKIFQLIDKSYFTIDCSDNETIQNLEQKIKKEKQIEKEFKLIFNGKELDKEKKINEYQIKHNSILRMIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJU8</accession>
    <name>A0A9Q0LJU8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_00851</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="155"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="484"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="1314"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="15">
        <location>
            <begin position="1608"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="791"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="877"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1064"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="953"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1564"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1064"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="176"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5074222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1784" mass="210885" checksum="330541C15406BEF7" modified="2023-09-13" version="1">MRRVSPKKIQEDPIEDEIQDQIKIQDQIENQDQIENQDQIENQDQNFNISHNNIIQKNSIHNPKLQFISNNINHINQNNSNVNKQFISNNLNQNNSNVNKQFILNNINQNNLNNLNQNNSNNLNQNNSNQNNLNNINQNNLNNQPIFEEVWYLRDLNEKQIEAVKSDPNIPLLISAGPGSGKTAVLVRRIAYLIENGVDPSKVLAITFTRKAAQEMKERVAEIISSDLAEKIKICNFHQLCFQILSQHSDLLGFSKNFQVCDSRKQNRIVKECYQEWKKKKEVANRYSALEVENIKSPTNKQKSNKKSTEKTNQNSKKKSEQKSPTPTREEILENNRKEKRVISEFTNFIKRAKSQQQKPNEFIDDHRFIYNLYEKKLQEASMIDFGDFLIKTIELFEKDPSVLQKYKRQFKIFLVDEFQDTSEIQFKLLRMLVGRMSRITVVGDVDQCVYCFRGASPENFLSFQNYYPNSRHITLNQNYRSTKNIIQAASQMIQYNQKRIQKSLWTNNPQGSKIKVFYCQNPDLEAQRIADEIVKIAKTQYSYRDIAVLFRVRSVSIKFELEFSKRGIPYQYPKGVGFYNRTEISDIIAFLNFVVDQSSNESYMRIVNIPNRNIGQNTLKMIQMISKQERISFFEATKMAIEKNNDIKQKKGEIVEKRLLEKFVSSNPSKIIEKDTQWYIDSIKRRQISSLSKFVEFITKIIQKCKTLETPTSVINYILKKVKYFSLVRKEDNPKSNSLLNKKQQLVDYDNVFDENDDGTENYSRRKAVNELLVLSEEFYEKYKSIRNQQNNQQNNQQNNQQNNQQNNQQNQNQQNQQSHNILFILSKFTSQISDQIYKNFSENKCIMTTIHQVKGLEFPIVFLVRFNYGVLPLPQIGGEENENPKLNSNKKNKNSNKKNQNQNQNQNQNQNEIENQNQNQNQNQIENQNSFQFQKLNQNQNQIENQNQNPNQNQNEIENQIENQIENQNQIENQNQNQNQNQNQIENQNQNQNQNQNQNQNQNQNNFHVDIEEERRIAMVAFTRAKEHLFLSFVAYDSNGKKVLPTPFFQEKNRINSFKNQNQNQNQNQNQNKNQNQNQNQNQNQNQNQIQNQNQNQNQNQNQNQNQNQNQNQNQNQNENQKKQIQLLNRSPSISIEEDKKPINLSNQRKNNRFKNIIKKVKNNNTNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIENQIENQIENQNQNQNQNQFENENKNQNENQNQFQNQNQNQNQNQNQFENENQNENKNKIDFDFDFEINSRIEKAQNLNKKNNFQITPNIQQSFYKNLLQRYKSLYYSPSNFHDFIIKVGKNYKPFKCHRCILEFQSPFFQSFLHEKNPEFACFPDIDEDIMEQILKYIYTGEIDIEQLDLFDLWTASNFFKLDLLSNSIQDEVSKNISNENVVNIYLKTFNNLSNDLRLKCLIYLVQNFYQLKEIENFIQLNPIHIMEIVNFGISHSIFTNLVQLLLHLKNWVEDIHLPSLCLPSTKKEIKRILNPLMEKIIPSVNQEQIRQIQQLDFIPKYLFIQLENMLNPSEKKVIDLQEINDDYDNYKDDEKENFVELKRKMEQLKRKCENYEKIIQENHKMLETSFKTSRIITTISQYEYLKNWIQDDMFLNSMVLGFSKLIDGNSSEIFHQKCDNKGRTLVIIKTFDGFIFGGYTISGFGKGNKGPIKDPNAFIFSLKNSKDEKPLKFPIRIEKQNEAIYSKDNEGPDFGAPTSDIRVNKDLTGGHTNFGKTYLLPSQIEFGFYSKTYLAGTYNQWEIEEIEIYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJW7</accession>
    <name>A0A9Q0LJW7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJW7"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="68962" checksum="4A98887827CD4CB5" modified="2023-09-13" version="1">MNDCIFFGRNEAPILLKNEPDKITKPIQFKFENENENEKQIKQIATGFFSTIFLFENGKAIEYLNENDPNQNPHKIQIENIQKVTVGANNEAILTIEGNVFAKGKDINPDNPKEFINISSLIEDTNDRIIEDIICGVSSIYLLTSNQNAYVIGSNQYGQLGFDSKTLPKTQKPILMMKNVSKIFSGISSYHVFLLNSNQELFGCGYNESGQVGLGESRKERIIQELTKIQNIPKGKIIDIQCGRSHSIMLIEDEDENENPKRKLYSCGSSNNRLLSRNESNYEFTEIKSSLFENDDDILEISCGYHHSLILTSNSKLIAFGSNLFGQLGNQNRMNDQKIPIQIELPELRFNENISNYHLSCGSFSSFLYYSPFLSSFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPILYSEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNQIKDEIQITQEIINEIEIGIDYFQLNQTNPNLFDLLIKKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK22</accession>
    <name>A0A9Q0LK22_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant sh3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK22"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="469" mass="56335" checksum="44C2ED4272DBDABB" modified="2023-09-13" version="1">MSDILIEGYLELQIIKQNEISLKQSHWKKHYFVLTKQTLRYFVKKNKNLKGEIKMKTCEISFQPNEKFSVITIISDESKSPIFIKFDSESLMDEWIKEIVKIKKLPNLREVKERIAKSNPYLEPLIVGRVKLMKVFTMQYSHSNQNFYLVLIQDTQQQHQFFLDFYPNQKMEKFPDKRIELSNIKKISFFQLLDKTPGILTETNNFGDFVILFQNEPQTQKWITIIEQKMDQQKQFLKAAKRTIQPLFVAESPQIDMKENAHKFKKPARYTTIIPQPPIDPPQLTEEETQKIHEHFQYLVDKNLLFSLQIREAFENILQQMNTNENTNMTIEEIMWDEYKYLLELKRYISKGISLEKIQRNAKFKPKKFWVSSEGKSLCWSHLNLLKKKVKKIDMFSIESISEELDHTSSKKFSKLKKFELNLFFSIQSKEKTIYFMFNSLEEKRFWFPCLFALWKNYLEKRESFDFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLC2</accession>
    <name>A0A9Q0LLC2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RNF213"/>
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        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="630"/>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLN6</accession>
    <name>A0A9Q0LLN6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
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    </reference>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <sequence length="1370" mass="157601" checksum="196F127727FBA67B" modified="2023-09-13" version="1">MNIWEIIENNKNNKELLKQIESITEKQLKENDQKKSILKFSIKKQISKEIIELLISKGIDNINLKDKKGRNLLHISFLNNPNLEIIEYLISKGIDINSKDKKGKTILHYSFIYLKKDQLIQIIEYLISKGIDINSKTNRNETILHFACKYNSIQIIEYLISKGIDINSKTVINETVLHFACQKNSIQIIEYLISKGIDINSKTDENETVLHYACKYNSIQVIEYLISKGIDINSKTDYNQTVLHYACKHNSIQVIKYLISKGININSKTVYYETVLHYACKCNSIQVIEYLISKGININSKTVYYETVLHYACKCNSIQIIEYLISKGIDINLKTNNNETILHYACQKNSIQVIEYLISKGIDINSKTVQNETILHFACKHNSIQVIKYLISKGIDINTKTINNETILHFICQNNPKLEIIEYLISKGININTKTNQNETILHYLCQNNLNLEIIKYLISKGIDINSKTNYNETILHFICQNNPNLEIIEYLISKGIDINSKTNYNQTALHFICQNNPKLEIIEYLISKGIDINTKTTNNETILHNVCRNNPKLEIIKYLISKGININTKTNNNETVLHYVCRNNPKLEVIKYLISKGIDINTKTNYNETILHFICQNNPNLEIIEYLISKGIDINIKTNNNETTLHFICQNNPKIEIIEYLISKGIEINTKTNNNETVLHYVCRNNPKLEIIEYLISKGIDINIKTNQNETVLHVACRNNPKLEIIEYLISKGIDINIKTNQNETILHIACINNPKLEIIEYLISKGININIKTNNNETVLHYVCRSKTTVKIIEYLIYKGVDINAKNNENETALHIAFQYNLPFEIIEILIENGIDINTKSNQNYTALHIALQTRSTFEIIEYLVENGADVNTKTFQNETTLHFALQNNTFEVAKYLISKGVDINSKTNENETVLHYACQYNPSLEVIKYLISKGIDINSKTNNNETSLHYVFRYNPSLEIIEYLISKGIDINSKTNNNETVLHYVCEFIPSLEIIKCLVSNGIDINAKTDENETALHIVLQTNPSFEVIKYFIENGFDVDSKTNQNETILHIACRNNSSIEIIKYLISKGVDINIKTYRNETVLHLACQFNPQLEVIKYLVSKGVDINAKTNRNETALLCVCHYKPQFEIIEYLVSKGIDINVKTIYGETALHLVCQYNPQLEIIKYFVSKGIDINSKTNNNETALHFFCRNNSTLEIIEYFVSKGIDINSKTNNNETFLHLACQFNPQLEVIKYFVSKGIDINSKTNQNETALNCVFQFKPSFEIIKYFISKGIDINSKTNDNRTILHYACRNQNSTFEIIKFLVSKGADVNAKTNQNETILHHAFQYNLSNEIIKYLISKGVDINAKTNQNQTIFHLAFSIQLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMG5</accession>
    <name>A0A9Q0LMG5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMG5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040183206" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="448"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="896" mass="101472" checksum="4DB944F90F4DB308" modified="2023-09-13" version="1">MKSILFFSFFFFLIINIFLIQSNQNQNQKSISSSLISPILTEIKTLTETTRYYSTPDEAWIWNLLDQFPSSGYFGWSVSIYKDVLVIGTRYLNQVFIYRYNGTNFELEQTLNESSVTHFGISVSIYENVIVIGADYANQVFIYRYNGSIWNEEQILNESASNFGRSVSIYENVTVIGTYYANQVFIYRYNGSIWNQEQILSESVSYFGSSVSIHKDVIVIGTHSANQTFIYRYNGTFWNQEQNLSESALNFGFSVSIYENFTVIGAYGAKEVFIYRYNGSIWNEEQILNESASYFGYSVSIHGDAIAIGASVVNQVFIYRYNESIWNLEQILNGPTSNFGNSHLFMNNLIPQVNIVNCSSSFSSFDCYWDEIQITTLEYQINYGYDWIDIDSPILEDENVYYQQFNSSFYDNITGNEYYSIQIQACNNVSMKCGESSSLINLTTKIDSVKDFQLSNPSNNSINVTWNYPNVQINEGIAHLDHYNLSYFNQSQPDLISFFSVDNSSLDYFLNNLECENDYNISICGCRTQECEGDDKGEIVESLFPLIFGEVTNFSCSILYSIDINCNWNQPINCSIPFYYNLTYQSISQNDSGNYQPTSTNQQFTVQLPNQEYQINISSCNSNGKCGYISSISITTDNLPAAPTIYETISKTEEIEFNFTKLTNANNYSISLNNGTNWQNFTSLDLSGNEVIGIISGISGNIEYNISIRGCADLNCETPYLGLPSSIISTRAKLGNITSLNCYAIINGFACSWDSLILSSGLKAYSFRYNLITICLTNLLAPHYSITSGLEGGEYYEISIYSSADLNCSDNEYSGINSTTSITILSPYQPTQSTDSNNSNTTAITIGILIPIIIILIVIIAILLYQKKTRKKQKQTKNLNQKQEQEEKELQADLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMI2</accession>
    <name>A0A9Q0LMI2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMI2"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="181"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="295"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="400" mass="45963" checksum="CC2BBEC0E1827453" modified="2023-09-13" version="1">MNDCLFFGLNKNPKLIKNKPKKITKPIQFKFENENENENENENEKQIKQISSSNHSTIFLFKNGKAIEYLNEEYSKQNPEKIQIEENIQKVTVGDDNEAILTKEGNVFAKGEDINPENIKEFINISSLIEDTNDRIIEDIVAGWNSIYLLTSNQNAYGIGSNYDGQLGNCSTCVFLLNSNQELFGCGGNFSGRLGLGESIKEERIQKLTKIQNIPKGKIIDIKCGNYHSIMLIENENENPKRKLYSCGDHQYNGLGKNEKTFEFTEIKSPLFENDDNILDFSVTYKHNLILTTKGKLISFGNNNWGELGTGDTNDQLIPIQIELPKLRFNENISNYHVLCGAFHKSFLYYSPPYFSNLEEDLIKLFKRKEFCDISFKTENGEIIEAHKLILKYRLNENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMZ6</accession>
    <name>A0A9Q0LMZ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_06645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMZ6"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="5"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="316" mass="37061" checksum="1EAC3C6B2C90572C" modified="2023-09-13" version="1">MVHYGTVADLLGVSLGIFGSSTIIFVHFKFPELRTFYRKLVFILSVYDLITALIYSLPGYYNHFICKIQPIFIIFFVATAAFWNAVISIITFFTVIKRTPVKTLDKFQKICHIILLVISSTMAIILIIFYHPEYNGDSYWCWVKEIKITIMIYSVWWSYALISVLFYITTVIKIRKIFRDISTIRDHDLRKKQRKEAKIQLRMTMIPIIYILVIFPTSFKRARQMANQNAKPWFVLDMFQAFFLSTQGFWDSILFVFLIKRVRVKLFALCSCSKQKRAVITAIPLSKDEIDYERFRNSSEDSNSDSDSKPINDGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNF0</accession>
    <name>A0A9Q0LNF0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNF0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="398" mass="45124" checksum="DC64359BCBD43992" modified="2023-09-13" version="1">MFNPNFYYNENSQLDFLSDDSYNDVAALVIDNGSGMIKAGFGGDDAPRAVFPGIVGRPRYLGVMVGMGQKDSYVGDEAQSKRGILTIKYPIEFGTVTDWDDMEKIWHHSFYNELCVAPEEHPILLTNPPFTSLRQKEKYIQIMFETFNTPATYIALDLVLALMASGRTTGTVLSSGEGITTCISIYEGFFSKNSIFRTNLSGRILTEFLTEILCDSSSYFPTTAEREIVRDIKEKTCYVALDFEKELKISRESCSLHLSYELPNSKTIQLNESRFKCTEALFQPDLVGMDEIIPIHKMIYESIMKSPIHNRKDLFNNIVLSGGSSMFNGISERLEKEISLLIPKTTTLKIITPPERKYSVWIGGSILSSLTTFQNRWISKEEYDEFGPTICHEKILYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNF1</accession>
    <name>A0A9Q0LNF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-like without caax 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNF1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="206" mass="23946" checksum="1B88C5DE471BAFF7" modified="2023-09-13" version="1">MQEMITISIIGAKEVGKSALSTQFCYSRIIEEYDPTIESYRKQIEIDNEILIVEILDYDYFFTDSDEIQNLKKENYRKSQGFIVVYSIIDRNSFDELQNYLNEIYLIKNCDDFPIVIIGNKNDVENLRQVKKEEGEEFAFKNGCSFYEASSGRRNNVDESFLTLLREIRKYPFDSKSNSKSNSKSNSNSNSKLNSKSNSNPNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPE5</accession>
    <name>A0A9Q0LPE5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPE5"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="180" mass="21019" checksum="82B83D454E109632" modified="2023-09-13" version="1">MSFDFNFKVVLIGTPRVGKTSLIIRYIDEMFKPFRPTTVGVDFKFKDLEIDNKIEGTLKEVDYYIKEIDDNCRIEPLIVIVGNKCDLIQDQIENIEEKIKEILKGKELRFFKTSAKDGINVNELFEFIAKELKEKKEFNKNLHHKKINTGLDQNENNLNQSKVIKNSDLTQKKQKKQGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPN7</accession>
    <name>A0A9Q0LPN7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clustered mitochondria protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPN7"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLU central" evidence="2">
        <location>
            <begin position="54"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="337" mass="39323" checksum="83C61CD646183984" modified="2023-09-13" version="1">MVSRIRPELLRKIGKIRMKNIDNEKNIDISQFARDHLYSYSLPKFISKMDNLEVIVVDSQKLKDQLHLHGINIRHLGVLANLTKIPHVRQLLVIEMIARVCKKSLYEQLRKTSKRIKNIESTEFANLVAKEEDKEVIENENENENGNENEIQNGNENEIQNGNENEIQNGNEEIKERKPEYGFQTPKKRILKKKTTDIDLINDSIEKSGHTELDSPRNHRVVARINERMASIIIDFFNLVLGSSEECEMYWDVVLIPGVLKKFGFKADFSMIHKPALFLALQFHSGVEFVDTDEYDFSKENPIERNDFVAIHPKLKRFLQPKMLSSNLRKIRQIFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ97</accession>
    <name>A0A9Q0LQ97_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ97"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="386" mass="45144" checksum="B850DB52B77874F4" modified="2023-09-13" version="1">MSQQNKQESNQSSEDLNNSVENQNTNQIINPTANDTNQDQQSQFELEQQQHSHINPNTNHSFMNTTPHFLQQTANYYPFQLSSFPYNFSYPSYHLNHLQNHHHLPHSAYPFFQNMSIQNFQHPPLSLTPHHQHPQDTNPHELANARGVMSLIDLVSSTFQNEPNKTQEIFYLINAYSSGNITQNEASHLIENILENKPDLIPLFKNFIFSGHPIFSQQIQLIPKDQEQNENENQIQNQNQNEIEIQNEIENEENLNELVIDDEQNKSNLFEKKRLQDAISLINNVNARFSSKPEKSNKFIKIIQQIEDNEINISDGLPEILHILKKEEDLKKEFQKFVVPLTLNEQSRRKTKIKTRFSTKIKKKKRSLSDEDEDEDESNSEYSNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQA4</accession>
    <name>A0A9Q0LQA4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQA4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="204" mass="23807" checksum="086041A9FFBB20FD" modified="2023-09-13" version="1">MSNSNFGIETNFEMNSFDEESLPLPFQSDLLLSSLDFLGYDFLDSKSIDFNNIDSVQLTTATTIINPSTDDPKTSTDLKEKIEELIQNRKKKRNQTKTAFRLQCFSQISPKEFVYIRRNKKRIQIGKNFSLKKHGMEISDKIVITSKLIDLETQINKRNKNLIRRSYRNAFKPKGFIIAKPHKRGDLVFKFVGKHKKQNRNIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQV8</accession>
    <name>A0A9Q0LQV8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQV8"/>
    <dbReference type="OrthoDB" id="4737882at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="126" mass="15034" checksum="22DED18F3E685E68" modified="2023-09-13" version="1">MKNSNKMKDSNEMNDLNEMKDSNEMKDLNKMKDSNEMNDLNKMKDLNEMNDLNKMNELTELSIMEFIQNKMEIDIFDDIGLSSPTFKEQAKLKHLLFFQNHLKYDLKKIIEKLPEKFKSEMVAFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR03</accession>
    <name>A0A9Q0LR03_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_05955</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR03"/>
    <dbReference type="OMA" id="QSYFHRE"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="681"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="871"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="14">
        <location>
            <begin position="448"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5077432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="977" mass="111686" checksum="9AF555BD85BC7233" modified="2023-09-13" version="1">MKSIHLVVLIVIFHLVALLSVFDIYFRSPIVYGMDQHKASERVREIEGTKQTEMKPEAPAKRLILFSIDGCRADRFFLAEPKFLTEKIKKQGRYGISHTRVPTETRPGHVAMCAGFWEDLSAVTRGWQENPFEFDSVFNQSFSSFAFGGPDAIEIFFKKNQKRNLTTFAFTGDDEHFTGPLDTLDIWVFDHADELLKNATWNNSLLTQMESDKVIIFLHLLGVDLEGHAHLPLSQEYTDHIRRVDARIQKFVEAIEDFYGHDNRTAFIVTADHGMSDRGAHGDGDPMCTQTPYVVWGAGFSGPVPLAQSPSLSSPNPQIFDTRVFDWKLENFLMKDINQADIAPLISAVLDLPFPMHSVGTLPIDLLDTSPQFRTSALIANFDQMYSQLKMKSSIKQKNSLSFLFRPFKPLDPSFVDSEINTVISLAGEGKFDLANQKVLNLIQLALEGLHYFQTYDWFFLRSIVTLGYVGSILSAITLALTKTKPTTNSQNHSFFTLSSILVETFVFIVSLSVFALLFVQHSPIQYYLYSIFPLLFWREILHNLSFWKHLLSHFFRNFFRNSILLLFVLGLLQLIVFGYFKRIVFSLAFLFLILIPFIFSTSNTKNKMTARFKALWILSCLIMSVFTALPIIKGVVIDIISIAGVIVVSFLVFSLLLNFTSFISILRSPSEISLWKGSKIHFLTAVLQLVLVALSFVSAIWTSLIFSKGGGLSQTNMILNWSILASSIPLIFFASPDYYHRLTSIFIGLLPGFVLLSVSYEPIFYVFLCFSMFLSMKLICQLQTNQKEDQNQKNQKNFHKQEKENQKNFHKQERENEKNLLPLNVQLLSIISLFFIFWFNISIFGAGNVASVSSFDLSATFRFETRFRPFTMGALLAWKLFVPFIPVLLTFEIVAKFLQISLMQVVLFVFALADFPAIQFFFFVRDSGSWLEIGMSISHFIIFDLFFLSIFILLLVSKIFTFKINVPFYNSFNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSB1</accession>
    <name>A0A9Q0LSB1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Diflavin flavoprotein a 2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSB1"/>
    <dbReference type="OMA" id="LELEMIC"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07709">
        <property type="entry name" value="flavodiiron_proteins_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00729">
        <property type="entry name" value="rubredoxin_SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051285">
        <property type="entry name" value="NADH_oxidoreductase_modular"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045761">
        <property type="entry name" value="ODP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048574">
        <property type="entry name" value="RUBY_RBDX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32145">
        <property type="entry name" value="DIFLAVIN FLAVOPROTEIN A 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32145:SF11">
        <property type="entry name" value="DIFLAVIN FLAVOPROTEIN A 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19583">
        <property type="entry name" value="ODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21349">
        <property type="entry name" value="RUBY_RBDX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="6">
        <location>
            <begin position="268"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1129" mass="127737" checksum="5CBCC918F79A4027" modified="2023-09-13" version="1">MEAEKLQAVEIQKNFYWVGALDPDIRIFDIVMYCEFGTTYNSYLLKGSEKTALIETVKDTNDSYRQFEERLNSILKKGEKLDYVIHNHAEPDHSGASYRLLSEKFPEATIIASRNGVENIKHMYGDDAEKFRFLEARDGLIVRLGGFTLSFMMNPLVHWPDTMFTYCPELKTIFTCDLFGSHYSSPKIFKDLLDEKETADMWKAAKGSYFDPIFGPYKKYVVQGLDKIKELELEMICCAHGPVIRKNIEEYMEKYREWSKITLPKNKVLIVHIAAYGFTNRMATLIKQGLESIGKDIEVKMLNFLETTETEIMKELGESRGLLLGSPTLLSDAVPPIMKIAANLNPVVHGTDPETRLVACSFGSYGWSGEAADNICQRLAQARVRIPLRPLKVQLRPSKKQEEQCVEWGAKFGRLMLGLDPVDEDLEKKIRIKQTSFRKVLNPEMAQNIGRKTFRDAQDGKIYKWRCIVCGEIVYATMPPEVCPACGVSQEVFVMEDEVENFPDDWELSETLQGVTDKIVVIGASAAGVSAVQAIREQNKKAQVTLISGESAPPYYRPSLTKYLLDDRRIEEEAFQLVDPQWFVENSVEFLLGTVVTNINIKKKRIELQSREKGAGKKKQISYDRLILAVGANQTLPKEKTSIFHKRAKTDILGEATSKKINVFAFRTLEDSKRIKSYIRANKVNSAIVLGAGPLGLEVMEGLLGLGVKEIKAIESRKHILSSRLDDQGSLLVQKFLKRHGVKFHLGYEMHHILDNSNNKKYKKTEKTASNLAHGIAIQSIDIEDTSLVEIYADIVIFATGVHSEMSLAKKIGLTTKNGIVVDSRMKTSNPDIFACGDCIEYKGFNERSWRNAQASGRVAGLAALGDSAVTFRVSVSPYAVAFAGLNIFCIGNIHEPTLESVSFVSQKIPAYTRLFFRDEGFRSVICGAMLITTETSMIVSIEQHIRAQTPFKKAIKSLIVHTFAKDKKKQVLSKRAKARISKSNIPNLYTLFHFKEGFTAFHRFLCDEFTEETLDFWVDAENYAQIPDNNKSQAPLAKQIFHDYLRYGAEKEVNIDHFARVECSDRIKNNDIDRTIFLTAQRQIAELLQSDLLKRFLRSPEAKPVIEKFGNLQDKIEKNSEDESTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LST2</accession>
    <name>A0A9Q0LST2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor tfiid subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LST2"/>
    <dbReference type="OMA" id="HRRDTTV"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="115" mass="13428" checksum="7FDBD551F2728FFE" modified="2023-09-13" version="1">MSEKKLLSKRAIREILARIEPFQSIEPDAQKILEELAEEFVHQIVNSACEFAKHRESKYLNVQDISLSLEELWPLSHIPGIQNQPSQNQQPTEAHFKRQNEVEESKLEQSVHTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTX4</accession>
    <name>A0A9Q0LTX4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTX4"/>
    <dbReference type="OMA" id="HFASEYN"/>
    <dbReference type="OrthoDB" id="10250315at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="537"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="636"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="670"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="753" mass="86416" checksum="FC493910FE003BFE" modified="2023-09-13" version="1">MNKIYEIIKENKIEKIKEIINQNIKEIKKKEKNKIIKYSIKQKLNKEIIEYLITKLINNNDNININNIKDKKRRNLLHISIKNKSKIEIIELLISKKININEKDKKGKTALHFASKYNSIPVIELLISKGININSRTIKNKTALHFACKYNSIQVIEYLISKGFNINSKTEDNETILHFACKRNTLEVIEYLISKGIDIDSRTINNETVLHFACQNNSIQVIEYLISKGLTVKETSIDNITSLHYACKRNTLEVIKYLISKGIDINVKTKMNENALHFACKNNSIKVIEYLISKGIDIKEKTRWNKTALHYACRDNSLKVIEYLISKGIDINTTTRWNKTALHYACKNNKLEVIDYLILKEADINATTEDNETTLHLACKYNSIKVIEYLISKGIDINTTTKWNETALHYACKYNAPFKVIKYLISKGIDINEKTYKNQTLLHLICEKITSLEVIEYLISKGIDIYEKTKYNETVLHYACQNNSLEVIKYLISKGIDINAKTRWNETILHLACQNNSIEVIKYLISKGLDINAKSEDHETPLHFACRNKSLQIVQYLVEKGVDINAKSDFNETALHVACWMNSLEVIKYLISKGLDINAKTDRNQTPLYVALNLNSFQVIEYLVEKGIDINALTDQNETALHLASQNNSAIKVIEYLISKGININALTSINETALHYACENNSSIELIKYLISKGIDINAKTINNETILHIACKNKLSFEIIEYLVEKGIDINEKTNQNQTALHLCLSIQFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUA6</accession>
    <name>A0A9Q0LUA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_05672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUA6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5077573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="241" mass="28884" checksum="BD324D0B7F969729" modified="2023-09-13" version="1">MYFDENSGISSTPLSRKDTLLSKKNNNKSSNKVVVFDPKKRINYLKGFSKRKQKRKEKAQQEIKQKEKEEKKRVKKESERIQFSSLGIPIFETTLNKNGFIKENDEEINEKFTFIDEKLKTTVTIMNDLNKDSLYKFNFENENENENENEDENENENENENENGNENENENENENQCEFGNKCELKKEKNPKKIRKVWSKNQQIKSRRKFKKQKKIQKKQNSKPKKVRKVQRKIQCSCKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUB8</accession>
    <name>A0A9Q0LUB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUB8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="432" mass="49735" checksum="8D5AEF8EBE9A2D1B" modified="2023-09-13" version="1">MNDCLFFGLNQYPILIKNKPNKITKPIQFKFENENEKQIKQIASGYFSTIFLFKNGKAIEYLNQNDSKQNLQKIQIENIQKVTVGVQNEAILTIEGNVFAKGKDINPKNPKEFINISSLIEDTNDRIIQDVVSGYNSIYLLTSNQNAYGIGSNFFAQLGFDSETFKKTEKPILMMKNVSKIFSGIPSYSVFLLNSNQELFGCGYNCYGQVGLEIKETEEENMKELTKIQNIPKGKIIDIQTGNWHSVMLIEIEDENQNQNPKRKLYSCGEPQFNGNSQTEYLTSFFEIKSSLFENDDNILDFSVGYENTLILTEKGKLIGFGRNINGELGTGDTEYKPIPTQIELPKLRFNENISNYHVHCGVYNSFLYYSPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLKDYENQIEKLQEIISKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUU3</accession>
    <name>A0A9Q0LUU3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spatacsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HFEKKNF"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028107">
        <property type="entry name" value="Spatacsin_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14649">
        <property type="entry name" value="Spatacsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spatacsin C-terminal" evidence="1">
        <location>
            <begin position="2244"/>
            <end position="2529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2589" mass="307702" checksum="8736B8297C5F7FF2" modified="2023-09-13" version="1">MSQIFETFKLSRFKSNKFLLENYQDCKFYFPFLLLVTRKNELILKILTKKHFEKKHFEKKNFEKKNFEKKHFEKKNFELQTIENFTLQNISNFFIAKNSNGSFLLTVIDSQNNVYIVKIILNSNNSVSSENISVVESKQTTNSNGLLLDFNLQLSQLQNSKHSIIIIKQIFSKNQILKCIQNEETKQFIQTISSIELLEIKNSQKYQFKMLWILNNNVAAILKFSQNQLFFKHLFTLQPQIQNSSNQSFYDDRQAFIYLNNSDFFLVSFDSYFHQYPNHSTLFNEQCFHFLKSFRNGFDQEQHLFPKHTPFEKYHSVNRTKIPSAMQAYLPRNILRKNWYFGKAIISTKHIGFSFKMNPLNFDFMTRWDTKSPYLFSPPWTSKFSKYLVSTKTSFNTKSLDSSLKNTHMSISQNQIILFSHQNISNDSTLKLQSISNFGNDFLLVFQQNNLIQLSFLSIDKKQAKLIINSYPFQEPCFIIHKGNGIIYTLTQNHINISLLAISFSQIIEHLLSVNTLDNFQEIIQINRWDIHKIWKQIFEFSLKNQRTDILKNLILESKIDEKFTSYLVAFSKTVEDLIIIKHHQSDFRSFLSSLLPILTQLINQYSQHFFSSISLESQNLIAKVEWKSTKYTLSANLPNQITSHFAENFVSLSQIFAELISKIITVFNPITHKNEDQKDPISHSNKLMDEMFQFCIEGDISKSLQILHQIIIFPNQKIFSKKQWKLITSFHSDLDLLDVFKHVSLGISHWLFSQNHIEFALKILNVSFLDPHSLLHQLYTLTLDKTIRNILKQLIQSSQEISFSENLLSLLDNQSNISNDYKLVLNSRKRKYPSETQLNINQYQQTKNLSSKIKENSRNNKLLENWNNFSNQIQAQKIYNEIYSCRNIDDEKFKIPLESHDFSSLPISNTNQNNLPQNQLLEINSPLYFVSRYSWFQQWSQSTQQRISLEFDHISNNTSIFHNFIQQNSHLETLLSDKIRYFISRFDFISLSHLIKIHQKEIVSDKKTALKLFSNSLSYCSNFLRTKIENYLIQNSILSFKNFSNSKDFLFHLFYSSHFFHQEIYEIVNNKNNLLQNIQIKSNIHSVNQILEQFIIFCAENSLFNVLNLIIYHFNFPLENLLQKEKPSQILSWLKIFEIIQNESNILHSNNEKIYDLSLLNFQAISNIEISSDYPLIWISSMIYSDRFPSLFQINEKNQSNEIHSFFNKYSKLYSFTFPQKFLNQFEKFSKENENWNNQLNYFSSRFDCSIFQLICEERKMKNIKSYILQTITKPLSNLFYVANPNYQESFDIVFHLIFQGSFSGFYFWNKTLHNKIKIDLQQNDYLNTLHDLVMIIAIENFLNNSHVASSFVFLELMGISTQKMVLFCFISKILHFYYQINQHQSPFFYQQNEDEKELQSLWDFKIINFQKMFKNITFSPNINQKVKNQLFSLIIPNKSENVEAIYQQLLEVFNFFRKRVRQRYSVNNFIITFWIFKSIQLFSTFYSIDFSNSLISIFLEDGDWIHLLDLFSNCELKSEQIILMNQEEFNYNELYHIPLIFRNLLSSKPLLSSKLSLSKQKIIDFNILEYVIMIQHQYLHVSNLIEKGIVSKQPIYITTADNISNNIGLIPLMIAYFCAQNIACKDIVQILFQFPEFQSENQEEILNQEELSQKKLIELITQNSIKMNHFNKIILHLVEKKENYLVMKAFEIFDNGNLIQYFLKFIRFFQMNAFTKCKLILESFPENFSLETKQRIGDHNWVFFVSKELFKMKFDNQFNSFQQKIFIRILSKWKLLALVFPSLYKMVKFCTKIQNSNIIINIFHDHESNIQKLTQNSMTKEARIYSNEFGLSCDLIALFHVGKYLAPKIKLGFKIHNSRKLLIEKCNKIFKKWRIEQKEIVAEFFLLQIDLMGSFQEIITPQEYIFILEISLEWLESHSKRNLFEDYINTLKLMIKFFSVIIELGKWNKIGSFVRFLPNPNSHISFNENQFKNEFENDEYLGFTLQKLLEFQSNIDFWNNYLLSKFEKRMNSYKNRILQKITFTQQEIEVFDLIIAEMLRKRMVNEAIKLYEEFGFQTKLDLHIFESSCILAESQKLDHPEKLIPQELKRKFGKEKQIASKLDVILFLMKNSRKYKHHVNRVYIDLKISSEINISYQEIQKEPFKIVEILLNQELCGSSIFFKFVKEHQLLSPFLDGLLVEKCFNCILQHENDQIEDETNFGYFGDHKHLETQSIDDFFYQNKNFYHLLSLIDQQEFFARRLLLLFEKKTQNSAIKIKTKSKIFVRAFLCFEHTSSYKYKNMTEKSILKLILECQEQKNTELLSHLFVQIHNNQHLKLIFNYLQKQENGINLLFKRNPNLNNITNLRTVLLEFYSQKLMKNRALLSKVFEHFGLWTDLGNVLLENSHKKIQKITSKNYIPLKIHNFKKFHSIQKNLVKSSQCFSEAKLDQKLLKSISLFSEISIQIECSDIQLFGNVSKQEILKQKLTNFYHALTFAEIHNLDHEEIWAQCLFHQIIYQQNMNYTFLFITVFIIKKTLIKKLSQIYKLEISRIQNQSRKEEIKQNMASFLLEILPSSDYLCIFKVAKKLGFEKEAQFIDEKILSKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVA2</accession>
    <name>A0A9Q0LVA2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium/hydrogen exchanger 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000027">
        <property type="protein sequence ID" value="KAJ5079552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVA2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="105" mass="11965" checksum="20F83094ABD847B4" modified="2023-09-13" version="1">MSEDKFRVIFVHFNLTIEFLILGFFALFILILIRMLVVKYSIKILPESAIIVLLGVILGVTGLGFGLSEHLIFGFSTNLFFLILIPPIIFETIKQNSQDKKIFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVG9</accession>
    <name>A0A9Q0LVG9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVG9"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="233" mass="26404" checksum="FCE6B946D9DC3CA1" modified="2023-09-13" version="1">MCTKKICEPIVQRFKLGDSETICGILRKNLPSPSICYIWTNESVYELVPKYHPEEVFNRLIEKEFYTEADTLGKTFGLDILSLYEKAADKHFEAGNFDQANQLYCLSNVKTTKIVHQFPQVKRMDVAIFHLKNALEFPEKLHPDFVRAMSDLLLMCHLQQCLKWRSNSNSNINIKSNSKSKSKSKSNSKSNSKSKSNSKSNSKSKSNSNSNSNSNSNSNSKSNSNSKLNSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWC6</accession>
    <name>A0A9Q0LWC6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mical-like 1a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000019">
        <property type="protein sequence ID" value="KAJ5079960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWC6"/>
    <dbReference type="OMA" id="QLEGCFK"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="366" mass="43226" checksum="859FACBB7309698C" modified="2023-09-13" version="1">MSATICQICQKPILSQKMMAKGALVHPECLKCCECNESLSPVSAQLYENKFYCRTHLPKKPNSEKTANKPKKVFSFRKSPINQINQEPKIEKNSINEEQKKKKQEQFKKKQEMQKQREIQKKKELEKQKTQQENQRKKSIQDFKKENQELEEKKKQLQKKLENLKKNQNQNQNQNQNQNQNEDENLLKKIQKKKHKISELKKENQKLASQEEQIKNELEKLVNLQNSLKESITQSSQNQAQVINNENDPIKQENSQISQEIKDLNQKIEKLKNEQKENESKFQKKIKKLQNEKKSNQIQIQIQKSTLNGIDDLLEEENQFLVQQNNDYEHEIASLSQKLVQLSGKVLDLDSLYKKYYEISDSSDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX52</accession>
    <name>A0A9Q0LX52_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Electron carrier/ protein disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX52"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="672"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1058" mass="124093" checksum="7B4B10E38D3EDE54" modified="2023-09-13" version="1">MGNEGLSIRKIKRNKEKKFRRLIQKSTEPMILMDWKGNCLEANQPILNLFKMSKEQLLQSEITQITPEIQPHMNINSKQAISSIYTETYESQTGYYDFDFQYLDTEKKPFWVHGWSIPLKLVEKLLIQAIFVPITAPNEDLNEKIPENMSAITANLDTLTQQSDISDDSGDEISFGEMEEISKSSSTRSEKTTSNDETEKETKQIKSPFSPRGKIARKNSNSDLEKEFPIKNPSQALKGIAKFLRRRSNSNSGLDSFQKKSKKRGKSKTNESLKKETNLINVSDNPKNDDDSDLSWKEKYLEMEKKFKKLEFSYQILQKQESNRKITDQETLVMRLQNKTSENNELRTQLKEKTEKLEKIEQEYSQIKTEIDKIQNEKEDGMSILLNKLNQIRNQEKEKAIENNQLRSENADFSKLFEEQSKNFEKQQTQIQSLKESLEKIILEKNEMSSEFQGKLNSIRSQLKERISENNQLRLELNDSKSKLENSQNSPDLIHANDQIVAENKILEKQKDELNEKIGNLESQNKKLEQELEENTSLAHQHGMLLNQYKDISNENHVLKIELEEIRKLIVGIHSQTSSYLRYDSSEYDFSDDSESEQSSDYDEIKKRFSQSNISNLTHKSNPQSPKRLTKNFSSDNYIFPNKFLTGRRSNSETELSKYPIQFKKEIKDIEKIEELLQIPLAVDYFKEFLSQQLNSENLAFYLEVQDFKKITTIKELGERAVPIFEKFIKPESLFEINIDSKSRDDITQMITNSQYSHTMFDEAKDIVIKHMTFNSFEPFKNTELYTTLIKKLNSDTQLEYDKIKIGTLIWKKQNLELLNSGLRFQGIPRDPIKIAEELLNALIYMLNAHYSINSEQINCDSLSHTISYRRFIVSTYELQQIDLETLDKEDLFIFFLNIYNTLFIHSLISKGEPSDKNSKRKFFTENKYIISNHEFSLLDIQNGILLQNSNTKNKNTSEKYFKPNDPREKFISNIKDNRVIFSLLKLHEINPPLRIFFKENYSEELNNCTKYFLLKNVQIDDKQKKVRKNFHKQNKTKQNKTKLNQIKIKNKNQIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXG1</accession>
    <name>A0A9Q0LXG1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-related protein rab-5c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXG1"/>
    <dbReference type="OMA" id="KQDTFHT"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="196" mass="22210" checksum="D74CE95D729BF5E3" modified="2023-09-13" version="1">MENRSESKVVILGDSGVGKTSIAIRFTQNEFFIYQLSTIGAQCMERIIKVGDNMINFSIWDTAGQERFRSLAPMYYRNAVAAIIVYDITQMNTFEIAKNWINEILEHGDPNVIIALVGNKLDLEEQRKVKIKIAEDYARDEGIIFLETSAKTGDHIDDLFIEIAKKIPITPKKIPRDIETLNESSITKKSEKSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXX5</accession>
    <name>A0A9Q0LXX5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-dependent oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000001">
        <property type="protein sequence ID" value="KAJ5080785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXX5"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF287">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="4">
        <location>
            <begin position="89"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="379" mass="42461" checksum="DF5717B868C69878" modified="2023-09-13" version="1">MFSRFIEPSQKVLKNLAFQTVQNFSRTLTTNNTYDAIVIGAGSIGLQQQWNSKKQDCVHLRFSQHGKKNTDLISNGKREATCSQCIREVDEEALKSLIPYQRSFGMEIGFVDADRVKQLVPGINTDSLRGGIWSPNDGSASPLLSALAFYRYAKELGADFHFKEEAQEILKDSHGKVSGVKTEKSTFHAPIVIDAAGAYSTKLMKSLRLQVPVTPDSHEAGITEPTEHFFSPMVVDMRPSTGSKNYYFYQNSHGQIVFCITPDPVIPGTDREETSVFLPQVSKRMISILPRLQNVRVRRTWRGLYPMTPDGNPLLGWNRNLPGLFTATGMCGQGFMLGPGYAKTIRNSITNNLDDNDKTILKFVDPHRSFADQKKEVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYE8</accession>
    <name>A0A9Q0LYE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenoprotein t</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYE8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="163" mass="18981" checksum="22B6EEB28DC3965E" modified="2023-09-13" version="1">MKVIITYCGGIFGRYLWVANGLKEKGYTVAPKHGHSGYLFEVHLDDGTLIFSRKKTGRYPEPEELVTLIEKHLESQKEKKEEKEEKEKRKVFPQQTRTESNESRIFTKIQNILLAILQFLKIFLQTLFYEEPDETRPQPRQQPIPQNRRNSFSTLSFFSGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZG7</accession>
    <name>A0A9Q0LZG7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vesicular mannose-binding lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZG7"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5080243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="344" mass="40900" checksum="C6135D835DEAD0B9" modified="2023-09-13" version="1">MKNWILEISTQSGSNKNSFSQFIGIGFWFTKEKKKNGILFGNTNNFEGIGILLSEKIEVIYQYNSNDNLKQKTILQFPISYFGLKEITKLRVIYIDNKLIVQLDLKSIGVWNLIGTESIDLPTDYFFGITSSHFESEIYHYIYSFKIYEIPDSKSRNIISLRNEKEKQQKRVESYKFQASLDLLKKLENNFEDGEKEEEEVLIIERLMKKYSIDLFAEKIVNLIEEIIKIDLEAKKNYQKTKNLEITYSRIQNSFLEQVNLNIKYIEQATTDVIDQVKDIRKSSEFLNNRFDQIIFQRQTKQNLIAINKKSSSYFWVFFIIFEIVFFIFILNWATIQRNIYKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0M0B4</accession>
    <name>A0A9Q0M0B4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000007">
        <property type="protein sequence ID" value="KAJ5080570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0M0B4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="22691" checksum="F431F90D59F31AFB" modified="2023-09-13" version="1">MLIENENENENPKRKLYSCGNRYYNGLNKLIYEFTEIKSSLFENDDNILDFSVRNYHTLILTSHLKLIGFGGNFLCQLGTGDTKNQSIPIQIELPKLRFNEDIYNYHISCGDYKSFLYYSPFSFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNENQNEKLQEIISKNQLKNQIKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0M0F6</accession>
    <name>A0A9Q0M0F6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-actinin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000001">
        <property type="protein sequence ID" value="KAJ5080783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0M0F6"/>
    <dbReference type="OMA" id="MRENCGM"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="137"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="865"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="995" mass="116534" checksum="6B47033BA36C3EFD" modified="2023-09-13" version="1">MSRTGRTAGPRSQEWVRLQRKIFSRWVKQKLLRTRPEIQVNDVVDDYKDGVMLLNLIEVLSESKFEGKYNQRPKMSVHRIDNLNNALKFAWSKGVDMKVKPSAEQLEKGDQKAALALTWGIMMKFIKIDDGSGGEALNAKDALMMWCKNKTAGYKGVEITDFKKSFADGYALCAIIHKHRPKLIDLSSLDPNDPIKNLQIAQDAAEKYFGLEKYITPDEIRKLDENSMVVYVSEYYYGIAEQRKLDLAARRIKKLIVLTKENDRLKTEYNKTAKNFKDTLKRVEVVLEDRTIDNTMAGAKLRLEKFYEYKTKEKSSLISDQLDLESNYNNLAMRLAHHKRPEFKPEKGCSLKEVAQDMLHLEECEQERKVALHAELNRQLKLVNLATQHESRFNKLSDYFNEKQAYLNLREEIDSVSAAHFQLRLLDRYQKENETMIKTGVANLKSLSAELKQEKYEYQAHIEDHDKDIDAKFKKLDELARIKKPILDDHLKREEFIVKVRQMNDEHKDKYNKLVKWFQIKNAYLLIKEEIDSVTLASKNLNIFGSYVKEYEKYKDYDLVEFIKLGKEILAQEYKTEHSHYVYDITEYQGKSFNQNRFADITNRHDDMDAKFKQLSELANEKKGYLDEQLRLETKKEELRLEFANLISEFTAYVKLEIENASLREFGFTLEEVEAYKKVIDETDKQVLGNASKMKESCEKVKVEMDEYKVTNNPYTGLTIKDSATSFQTLQDALSERTKAYEAELKRQRENDELCKKFAQLADPFSKWITEQKDQITASKESLEVQLAFVDKCISSLSTEQAKLQPLKDLQEKMDKAGIQNNRHTTLTLKDLLVQWGQYENFLKRKKKMLEEEIEHQKLRGITAEQMQEIEENFKQFDFDNSGTIDRKELTACLYSLGEERTPKEINKIMEEYGDGKDISYERFKDFMIVLFGDTDTKDEIINSFILINRGHKVAKKDLMELVMDDQDIEYILKTAPQVDEGYNYHAWTEEVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4H8</accession>
    <name>A0A9Q0R4H8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4H8"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="440" mass="50607" checksum="60332821A1012351" modified="2023-09-13" version="1">MNDCLFFGQNQYPKIIKNEPEIIKKPIQFKFENENENENENENENEKQIKQISSGNFSTIFLFKNGKAIEYLNENNSKQNPQKIQIEENIQKVTVCYSNEAILTLEGNVFAKGKDINSNNPKEFINISSLIEDKNDRIIEDIVSGYNSIYLLTSNQNVYGIGLNQFSQLGFNSKTLPNTEKPILMMRNVSKIFSGNTSNYVFLLNSNQELFGCGWNSYGQLGLGESRKETEIQKLTKIQNIPKGKIIDIQSGFFHSIMMIENENQNQNPKRKLYSCGNYPCNGLGKDESTYEFTEIKSSLFENDDNILDFSVGQVHALILTSKPKLIVFGNNLYGQLGTGNTNYQSNPIQIELPELRFNENISNYHISCGFDKSFLYYSPPFSNLEEDLINLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNEIEKLQEIISKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R503</accession>
    <name>A0A9Q0R503_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R503"/>
    <dbReference type="OMA" id="CIQQVAK"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="237" mass="28030" checksum="81373F75180CA602" modified="2023-09-13" version="1">MTDWGNIAQQKPKETLEEISDQIFQIDKNNRQLEEYIKQIGKSKDDSKLRSNLQKIRNSSKKLVQSVNEKLMKEKNNQTDKHKWEKLFAQFNDVLKNFENLFRESVRKEREVIQILQDKEDKKDHDHDNEFQIQEVQNFNQTDLELIEERNRDLQNLEVDVQELHELFIEVAALVKTQQSGIDQVEHNVESADHDVEKGVEELQKASLLQKAARSKMCWIIICVIIIAVIFMAIFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R555</accession>
    <name>A0A9Q0R555_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sterile20-like kinase isoform b-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_13632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000143">
        <property type="protein sequence ID" value="KAJ5066434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R555"/>
    <dbReference type="OMA" id="VWICMEM"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5066434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="480" mass="54702" checksum="D0EDB8CA644C0D71" modified="2023-09-13" version="1">MTTDPSKLFDKTDKIGEGVLGSVYKGIGKDAKKPIALKVINLTETESKINDIKHLGITITKQSKNPNLMKYSGTYMKGNELWLVMDYFDGHSVTDLLKPGPLAEQHIAVILKNIIQGVRYLHSHKLAHGNIKCSNILVSKTEVRLTDYLVSSKIIQLRRHYKTFSGKVYWMSPQMIENNIFSEKEDIWAIGIAALEMAKGEPPFYNLDYEKGCKAIVESQPPKLTGSFSTKFAEFISLCLSKDPRKRPSAKDLLKHQFMKKVKKTRIVASLIERYAVWENLHRDIQNENESVNGNQKDSSLGEELLDDFNFVSTNETDKQNTNEKESPKESKSKSKRAITIDKKPKKEVQKKKKSESSSEFEEYEKTKGKKNSRKNDAMNADQPFTQLMISTLSKLKESQSEKSVLSNLSQMQTLFSFCEDNSKGFIKCFAQEVIKQIEQSNEKEVQEILSTKGKGSPLANETTTAQYVLERWKTKFDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5F8</accession>
    <name>A0A9Q0R5F8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5F8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="425" mass="50045" checksum="18ECB6DCA96E1700" modified="2023-09-13" version="1">MGNHSTVNHIRKMKTKRYFKMIEKTKDKVVCIDNRSRLIGASHTAISFLGLKGFKKYHKKSILTFLPRKQPDSNLEPNQIVQLLMNELSDCANSISFDIQIKNLLGELIKVQIWLSPLFLSGHSVTQIIIREMETIPNMKNPIEEFLSTKVSTDETTKTESEQKTQKTATTTTETETKYNENENEYEYDNFNENFNKNKIENKNQIQNENQIQNQNENENENENENESESNTTTTTTTTTTTTTFDEIEFQENQNQKCNRNFKQFYNQNQTYFRDGFNHSFSHPTFSKNSPKKPILDDFFSVQEIEGLIEKVDRKISNLISQKNKIQYLKSSDQQLKQMKNLISEKNKEINSLQTELEEANMSVNGLKKEIFKMESKCQNQKQKKEMFLKKFEEVKKEILKQRNETKRYRSKLETLTNQKKENFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6Y2</accession>
    <name>A0A9Q0R6Y2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6Y2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="97" mass="11672" checksum="57877FC638B67688" modified="2023-09-13" version="1">MKDKYSHQIRIFFITKIKINKSISIQTFACFDKFNFEQKKMVSFDFNTFNIQEYHKVLQLYVNGCFVKNVKHLLSFIFNITFLKCIFGTLSRQKQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R706</accession>
    <name>A0A9Q0R706_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_12476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R706"/>
    <dbReference type="OMA" id="PKEITEC"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="176"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="440"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="551" mass="63756" checksum="E8D27C096AC65B23" modified="2023-09-13" version="1">MSTKPKNRARFWPRRRTVHNKVSTNSHNSATIQFDLIKINSHGKKQRRNITLSEDGLSNSDGKKTKWFISSKDIYGIHKSKKPNRFSLVTFYRYRFQCENETVSDQILQGFRDLDLCLAMDPPDKPVYFIDENEEPKEKVSTKNTNSENTKHSKTKKPEIQEIKQDDREKIGPNSFEQLKLIGEGSFGKVYLVRHRDTGKFFAMKVLVKSEVFKRKQIEHTKTEQRILSSLRNPFIVTLHFSFQTKHKLYLILDYVKGGELFFHLKRAGQKRFPPILARFYIAEIVLAIEYLHKQNIIYRDLKPENVLLEPSGHIKVTDFGLSKEGILSNDGKADNGKANTFCGTAEYLAPEIITCEGHGKAVDWWSLGVLLYEMLTGNSPFFSTNRNDMFLKVIRANPEFPDYLHPDAVDLLSKLLKRDPSQRLGANGAQDIKDHPFFEDLDWDKLLKKKLQPPFKPKIEDNDPQNTECFDRDFTSKEVTQNSESLPFSIAPIFPDNMFDRFSFIRDNDNDDDSFGSDDENSDDETDNSEDEISETNEDNSNQKKNPKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7A1</accession>
    <name>A0A9Q0R7A1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho gtpase-activating protein 68f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7A1"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="Rho GTPase activation protein"/>
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        <property type="entry name" value="SH3 Domains"/>
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    </dbReference>
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        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
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    </dbReference>
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        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
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        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
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        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="6">
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            <end position="381"/>
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    <feature type="coiled-coil region" evidence="4">
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            <begin position="399"/>
            <end position="445"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069118.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="469" mass="54399" checksum="1BE9C871D490EDFD" modified="2023-09-13" version="1">MSNQNYNLIGVPIFSGNIFKYNESNKEWEEFFYILKDIYLFGFKNKNDKKPFFELFLHGCIIREERHPTKQNVFIIITKDEKTTLLFSTNSKDETKIWTSCLQQEVNKIKNSKQVFGESIENVLNIKKDGTPIPLVLEKTIDYFVKEKKFDMAIFKSSEFQDDIEEIKQNIDKGTEISFTSVKDPKVVGGLLVQYLQELPEPLLTFDLYSDFYHTLTMTPKSQHLPAIRSCILRLPLVNFFALKHLIGYLNRIVLVKTTSKDEISELFGPIIFHKENPSQTEIHEAFPIQKELFDLFLDQFRYLFKEENFQSKKQIYQDLDHKGTILEALYDYVAQGPRQLSFTRGDLIVVLKCDPSGWWAGKIGNTCGLFPSNYTRIVSTHSQPTELKSCLVPAQTTIEKAKKANKQLISQLNSFKQKKGEPAKDALERTIETMISQIKDLKLQIATQIGERLRLERIISKIITEDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7I6</accession>
    <name>A0A9Q0R7I6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5069373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6151291at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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        <location>
            <begin position="2132"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="2166"/>
            <end position="2199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="2200"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="2234"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="2268"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="2302"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="2370"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="2404"/>
            <end position="2437"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="2438"/>
            <end position="2471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2512" mass="287350" checksum="73B85C4A0FE9C774" modified="2023-09-13" version="1">MNIFQNKNISNKEKEKIKIIKKEFEKEISKETIEYLISKEISINFQDKKGRNLLHFAILNKASIEVIEYLISKGININSKTNQNENVLHFSCQKNTIQVIEYLVEKGIDINEKTKQNETVLHYACQNNTIQVIEHLISKGIDINEKTKENQTVLHSACKKNTIQVIEYLISKGLDINEKTKQGQTALHYACRFNSIEVIKYLVSKGIDINTKTKQNQTILHYACQKNSSIEVIKYLISKGIRIDTKTSYGETVLHYACQSNPSIEVIKYLVEKGIAIKSKTYQNQTVLHYACQTNSPLEVIEYLISKGIDINAKSIYGQNALHFACQINSSFEVIKYLVEKGIDINSKTKQNQTALHFACQINSSLGIIKYLVEKGIDINTKTKQNETILHYACKTNSSIEIIEYLIEKGIDINEKTKQNQSALHFACQTNSSLEVIKYLIEKGIDINSKTIQNETVLHSACQYNSSIEVIKYLIEKGIDINSKTKQNETALHYACRSNPSFEVIKYLIEKGIDINTKTSYGQTALHFACQINPYFEVIKYLIEKGIDINAKTNQNENALNLACQHNSSIEIIKYLIEKGIDINNKTIQNKTILHYACQSNSSIEIVEYFISKGIDINEKTKQNETVLHLACQHNSPIEIIEYFVEKGIDINEKTIQNETALHLACNYNASLEVIDFLVKKGIDINAKTRYGQTALHLACQSNPSIEVIKYLVEKGIDINEKTNQKETALHYACNYNSSIETIEYLISKGIDINAKSNYGQNAFHLACQNNSSLQAIKYLIEKGIDINTKTDENQTALHLVCQSNSSIEVIKYLVEKGIDINAKTNYGQNALHLICQYNAPLEVIEYLVEKGIDINTKTNENQNALHLVCQYSSSIEIIKYLVEKGIDINEKTKQNQNVLHLVCQYNSSIDVIKYLVEKGIDINEKTNQNQTVLHLACRNNPSIEVIKYFVEKGIDIQEKTKYGQTALHLACQLNPSFEVIKYLVEKGIDINSKTDQNQTALHYACQSKSSIEIIKYLVEKGIDINAKTKYGQTILHLACQNNPSIEVIKYLVEKEVDINAKTDRNQTALHIVCQSNSSFEVIKYLVEKGIDINAKTNGNETVLHIACQNNSSFEVIKYLIEKGIDINAKTNKNETALHLACQLNTSVEIIKYLVSKGIDINTKTNQNKTVLHFACQYNLSLEVIKYLVEKGIDINAKTNRNETALSISIQRNNFNIVKILLQNEVNIYDLQENEIKKEFIDSFIQIYSLNHDLNNLLNSNDNFSDLEIKSIDGFKFKVHKLILLTRFDNNNLILQKFINNCSYKTKEEIKIIINFIYTGFPDFEKIIEILNQQMNKNLKENRNKFYLGRREFREKKRILKEIEENENKIKEFFKEIEIDSKWIENKKRRKGIIKDLSKLYQQNETKDFKIIISEEKEIKVHKLILFLRSELFKGMFLSVSDTSNQVHDYSKKSNESIQQLIYFLYHDKFEKEINSKIIEENTIQVIEYLIEKGIDINEKTKRNETILHFACQKNTIQVIKYLVEKGIDINSKTKQNETVLHFACQNNTIQNTIQVIKYLVEKGIDINSKTKQNETVLHFACKKNTIQVIEYLISKGIDINSKTKQNENALHYACQNNTIEVIEYLISKGININSKTKQNQTILHFACQNNSIQVIEHLISKGIDINSKTKQNENVLHYACQNNSIQVIEYLISKGIDINSKTKQNETVLHYACRLDINSKTKQNETVLHFACRINPSIEVIEYLFSKGANINSKTKQNENILHFVCQSNPSIEVIEYLIEKGFDINEKTKYGQTVLHFACRNNPSIEVIEYLFSKGGYIDEKTSQNENLLHFACRNNPSIEVIEYLFSKGGYIDEKTSQNENLLHLSCQINPSIEVIEYFISKGFDINEKTKYGQTALHFACQYNSNLEIIKYLISKGADINAKTNQNQTVLHFACNYNPSIQVIEYFISKGIDLNSKTAYGQTALHFACQYNSSFEVIKYLISKEADINAKTNQNENVLHLSCQINPSIEVIEYLISKGININSKTAYGQTALHYACQNNSNLEIIKCLIEKGIDINTKTIQKQTVLHYACRHNSSFEVIKYLVEKGVDINAKTNQNQTVLHLACENNPSLEVIEYLVEKGIDINTKTNQNQTVLHYACQKNSSIEVIKYLIEKGIDINTKTNQNETALHYACQNGSSLEVIKYLVSKGIDINEKTKQNQTALHSACQYNSSIEVIKYLVEKGIDINSKTNQNETVLHFACQHNSSIEIIEYLVEKGIDINTKTNYGQTVLHFACQNNSSIEVIKYLIEKGIDINAKTNQNENALNFACNYNTYLDIIEYLVEKGIDINNKTNQNKTILHYVCQNNPSIEVIEYFISKGINLNSKTNQNQTVLHFACQYNPSLEVIKYLIEKGIDINEKTDQNQTALHLACNYNSSIEIIKYLVEKGIDINAKTSYGQNALHLSCQNSSSFEVIKYLVEKGIDINAKTDQNQTLLHLACNYNPSLELLNILLKKELILMLKQVIIKMLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7X7</accession>
    <name>A0A9Q0R7X7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7X7"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="198" mass="23041" checksum="E50970EF4D5A9EAD" modified="2023-09-13" version="1">MNLDNDNELQLRIGLFGAGGVGKSTITIRFIQNIFIGDYDPTIEEEYRKIFDLNDKKISLNTLDTARGEEYYQISWRWARYSQVFVYVYSITDRDSFERIIDFHKSATKCLDGNENYRKILIGNKNDLFTKRVVKTKEGKELANKLNCKFIETSAKNVENINQLFYEASILGIGELKNPKKNQKKNQNKNKKGKCLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R925</accession>
    <name>A0A9Q0R925_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R925"/>
    <dbReference type="OMA" id="DTIICGE"/>
    <dbReference type="OrthoDB" id="2347980at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF122">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN SKYWALKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="191"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="370" mass="43601" checksum="F9EDB4E44973055C" modified="2023-09-13" version="1">MQFKFYFSSKYLIDELIEISSNFIKNNLQIETIVDILKLSESMNLNQLLDSSYKFICGNFKEFIKTSHFFELEENHLNSILSNDKISINEFELFQSIIKWGKHKSNINQEKEIDKEKLQDQISNVIPKIRFIDFSKQELKDTLKEDLIPNQISQKLTQFQKLQKEEKELKQFIEKEDSLIFKSRIKFESEIIQEREHSNKLKEWINDDDFFSKMKKGFSAKKDGFSGRKLHTKIMKKGKVLIIIKTKDNFIFGGFTSVGWKKGNDDKYIKDSKAFIFSLRNDKNDRKPEKFPIKKDEKEEAIFYCSEDESIIFGDGPDFDLDSDLKGGSSNFGKTYKLPKGLKFRTKEAKSYLAGSYNKWIVDEIECFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R983</accession>
    <name>A0A9Q0R983_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor if-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R983"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="348"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="567" mass="63626" checksum="BE7B4A072D6F7942" modified="2023-09-13" version="1">MNSLDPSFLEAIDLFIDKKDTTEKKKSNTEQFEQKMNTKLNRKMNTKLNRNATATVNAKTNANSKLKANSKANSNANSNANSKLNANSNSNANSNANANFLLSPIEKLLINADYISDGTINVNANSCERSQCPCLPNLTTLSNLGYHHFLSHTSNIPALDNGDDISTSPINFTHNDAQCEVTLTTNPSEELSKSQKLTKIHNQHDNQSEFRCSICLTTESPKWFHSSNFSNPNIVGEWVCSDCKSSAKDLKRSTYNSSLNDTDFGIDNRRSLQRSNQQKNQKENEKLNKKVSPKKINEKVSPQKNNSKKRISPSPYSDQNAKMEDKNFKSKKKKLRKKTKKKKKKSTRVKQIFLGLRFHLKIYTGCQSGLEKNLIQTLQQLLSVHGGIVLDSLDERNADNVYIITNITLENAHRLEKIQLAELAKQAPVVNVGWIFDCIKSKAISDYSKFLVSETLSTLSTLETPNSLFDSLSFSFIGDLDWSTFWSSIIISSGGKVSSDNENLGDYLVEQNPVNFDHSDDVDPSQSPKVDNQTQIPHISLRPKIKRISVLRVLKALSLKTVEELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9G2</accession>
    <name>A0A9Q0R9G2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9G2"/>
    <dbReference type="OMA" id="NYETQMN"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042861">
        <property type="entry name" value="TEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47083">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47083:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="872" mass="101645" checksum="C1858414169801E5" modified="2023-09-13" version="1">MRDFGYRLWNLGITLKNKENRTFLNCEIRHLACNILSLLSVQTPDHALTLINFFSRTGKAWMDCDNFEMAETCFQTSISHLEKKGNLLKNNHKKWNSFFEVIFWRLKNAWQTSNFDLCLECVLKAKNEILPHIQEFIEQLTITCWNYGLISFKQQNYLQAIKFLHESFEISLKDPQRNPEKESRTLRLLSHCFLELGKNQEALNSVILANQTLETLPGIFLHLKIVQKMNRKQDTEIIFNELIKNPKINSQMAISACELIKDQPNLIMKGLDYLETQLEENEEDLIKIQMKKFEIMLISNDFNEEEAFKLGSLISQNHQKKQILLDSESLMHFHDLVWNQTAKNFAKKEYQKSIKWIKTSFEILPLDDTINRAKSLRIISRAQIESNQPEIALQTARRVEEIESGSILTRFSLFQAALANGIISEAFRQLSLFSRSDGFETKFFGLAAQLSHQTKKETLAISALIKLLESQNNNQNNNQNNNQNNQNNQEKVPVSMIISTILQLSLSLEEDLFENGNENEITFAQISQAFQISLSFIYQFGIDNFFLPDEQIPNKELEFLSFGIWNLALISSQKKKWQISSQLFYQASEFASFLHESPSILNFRQNCLLGASFCVLESENIPNEMIQLTLNFVKKSQEIIRKQQNSLHSFPRSEREKNSSPIRIVKNRFEQENEEKEEISQKEFTLKEIRFMLHLIEFECKAILNSSDLIQLVEKPPHGIASPELFEQMAIICFSEKSKNLEVCNFALQNALSMHLVQSKVDLIKIAMILRQLIEISESVQASFPFFEKWIQIKKEDQNNQEKNDSKREELDDLWFIANSWNNGVVSFRLHQFKEAEKWMSLSLSILHLNQNLTGYSKQMNLQYQLVLTKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAB9</accession>
    <name>A0A9Q0RAB9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_09297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAB9"/>
    <dbReference type="OMA" id="LVIHRTM"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="13">
        <location>
            <begin position="132"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5072851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="405" mass="46185" checksum="07FD117968810946" modified="2023-09-13" version="1">MENIIHVSCSGKILIIGGYLILEKENFGLVLTTNSRFHTFISSTENPNLISIFSQNYDQNYSYEFSTNPIFLKSTNPKIFPSNKFLETTLLFTLSFIYSSKNLSPLEKKGLKMTIFGDSAFYSKKSNDSMGKTGLGSSAALVVSLTGSLLHFFQIVDLANPKSEDLFLIHNLSQFCHCVAQGKIGSGFDISAAVYGSQKFQRFSQTVLKEYIEKPFEIEPHFLESFSKLINSKEKWDNFIQPFKLPSNTKLILIDTLSGGSETVPMVRRYLKWKNEKPQESSKIISHLKKNNSKMENLLNQKEILEEQIDQIRKIGTKIRFLMKKMGELSDVPIEPEEQSQRINQIFSIKEVIFAGIPGAGGLDAIFVIYIDKEDIFKEIEEKIRILKMRIIDLKIINKPIQLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAX0</accession>
    <name>A0A9Q0RAX0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAX0"/>
    <dbReference type="OMA" id="GVQLESY"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040437498" description="Thioredoxin-like fold domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="213" mass="24558" checksum="EAEC0ED3F2F4ADB1" modified="2023-09-13" version="1">MNKNIYFIFFLISIVFSQAPIPKRPDGHKQGDINAPVYLEMFCDLLCPDCAHSWPTIKNVLEYYGSSKIYFIFHVFPLPYHTSAFFMAEASLVLENYTQSLFWDLLDSLYIDSKQQMFWDDAVENTTLEGIKSLMGSYLLDEFGLPNSYFWNGMNDVTIDWNSRVSWKYACTRGVSGTPTFMVNGVYVAMGSDSSLNDWINLLNPLFLNKPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBG3</accession>
    <name>A0A9Q0RBG3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBG3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="318" mass="36921" checksum="FD437174209BD1EE" modified="2023-09-13" version="1">MASILEIVKRAARAASGTRSPQLYILGIISAILALLILYEIIRTIKLTGSIWKNITSRFRILILTSCFLEITLTSIVSLVSFNWKSVFLIIFFYTTLPTFLQFCTFSFYILYLAKTLFMIEGKQTKLKKYLDLIFVISIIVYFILLIILDYFTAKNVNEGKDNSTSNLLSALYIIIFIFPLVILFVIMGVKYYRKFKDYLLVSIQKERIKYIMILIIINGVIFTIFFIYALFGAFEKNKISDTVGTYLANEEYSKYDTYALIFTLVFGLIPAFVLFIILHRILSIEKGMFQRQENILLAGDDNNEYLNNEYKLFDVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBR1</accession>
    <name>A0A9Q0RBR1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane emp24 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_09188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBR1"/>
    <dbReference type="OMA" id="MILIGQW"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040371869" evidence="9">
        <location>
            <begin position="16"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5072974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="23790" checksum="37EED307E561AE7B" modified="2023-09-13" version="1">MKIILIILLILSTQAIFFDIKSSEEQCIIEQADSIILVSGTYKLKDPMQLNTDFIVYDPHQRIILRKQRIKEGTFAFTAELPGEYKMCFNTLTPQRYHSQSIVTDRVELNYKFGLAAVDYEEIAKREHLGPLEKELRKVEDSVEDMYQNMIYLRGREESMRDTNESTNARVMWFNILSMLILIGLGVAQVIYLKNYFEKKKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC97</accession>
    <name>A0A9Q0RC97_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC97"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="493"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="614" mass="71526" checksum="1724DB7ABDE17D49" modified="2023-09-13" version="1">MNDCLFFGWNKYPILIKNEPEKITKPIQFKFENENENENENENEKQIKQISSGLYSVIFLFENGKAIEYLNDSSNQNPEKIQIEENIQKVTVGYKNEAILTIEGNAFAKGKDINSNNPNEFINISSLIEDPNDRIIQDVVSGHGSIYLLTSNQNVYGIGSNQFGQLALDSEILDKTEKPILMMKNVSKIFSGNYSDCLFLLNSNQELFGCGYNYHGQLGLGESIKEANIQKLTKIQNIPKGKIIDIQGGFNHSIMLIEDEEENQNENENPKRKLYSCGDYEYNGLGKKNKDTREFTEIKSSLFENDDNIREISVGYNNTLILTSNEKLIGFGGNNYGQLGTGKKGIQKVPIQIQLPKLRFNEDISNYHLSCGYNKLFIYYSPFLSSFSNLEEDLIKLFRKKEFCNISFKTENGEIIEAHKLILKYRLKDENEIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENEKDFIIERKEKEYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIKIGIDYFQLNQTNPNLLDLLKNKFNNQNKKHKLKQNQKRDCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCM9</accession>
    <name>A0A9Q0RCM9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCM9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="108" mass="12815" checksum="B0984D38337220A1" modified="2023-09-13" version="1">MSSLSTTNWTFITSKNSRRKTSNPPKKLQRKSSEEKEQEKLNQNQNQNQNQNQNKNQNIIELEFGNEIDNEIDNDVDNQNKNQNQNKNQNQNKNQNKNKNQNQNQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCX8</accession>
    <name>A0A9Q0RCX8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCX8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="293" mass="33852" checksum="987DFE5E2E7281C6" modified="2023-09-13" version="1">MSSQDRYVENFLDEYGAELQNQNVEQIRSFSFPPNQRESQKEEMNINDTQNTNSTIQFNQKKMKSLSVSKKGNLIKNSKHFSNKIKTKKINGPPNQIMTESFNEKINSYSDSDSDSNSNSDSELDSESDLESELKSELEQIEKESSQQQNLIEQTDSMDIDQTESKSQISSDELQQFLSQKPAPKIGFRLDKIAAYNPSIIQGWSPNSYHLYIKKRIVPEYVELRDDVIELLVSLTGKQTRTQSAKLSHKNKQVKTDDWRNTRRGLTAFFTNTLGLTNQTNRQQGRMIFRRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD86</accession>
    <name>A0A9Q0RD86_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD86"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="242" mass="27708" checksum="74C987230637E6E2" modified="2023-09-13" version="1">MNEILFFGLNQSPILIKNEQDKIIKPIQFKFENENENENEKQIKQISTSLFSTIFLFKNGKAIEYPKENDSKQNPQKIQIEENIQKVTVGYRNEAILTLEGNLFAKGIDINPKNPKEFINISSLIEDTNDRIIEDVVSGFNSIYLLTSNQNAYGIGLNEHSQLGFDSKTFKKTEKPILMMKNVSKIFSGNCSRYIFLLNSNQELFGCGYNYYGQLGLGESRKEETNVQKLTKIQNIPKGQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDD2</accession>
    <name>A0A9Q0RDD2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein rab-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDD2"/>
    <dbReference type="OMA" id="QSHDITI"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="309"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="419" mass="49927" checksum="ED57B138E90613A8" modified="2023-09-13" version="1">MISKPHIKIFVIGNNFVGKTCLIERIYTGIFNDTGIFESNSPSQKKYFQFKNEDYQIDFLDHPGNLSFEDHIKNHRRIIDGIFICYDITDENSFRSLLELLENKKSLPKKAIKYLIGTKCELENQRQISKQRAQDFADQFGLKFYEVSSKENINIDESFTEMANDIISNIYSFENIEIVERLYDVGSIIEDLRKFYERKEFCDDEIECYDENNQKIKIPIHKFIIQNRLHINDNIFQKKIKPLLSKKSQKKIDILLEWIYFGRIEINSNYSIFKNLKEKLSKVCETTFRIGTEGLINDFKKIMNDEESKDFEIILNKERIKVHKIMLIIRSELYRGMFLAVNEDKSNSVYDYSHFKTETIRAMIYFFYTDDIPKDLRNLIYDELSQCVDYFHLNPKLLTTLKLIPKKKEDKNEKKCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDI2</accession>
    <name>A0A9Q0RDI2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_06211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDI2"/>
    <dbReference type="OrthoDB" id="6381660at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040174710" description="Fibronectin type-III domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="89"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="512"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="613"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5076631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="759" mass="84532" checksum="1A0AC118A3141B84" modified="2023-09-13" version="1">MIKLFAIILIIFLLTKQISNNYELKKVGNQWNRKQITYPNNPTNNIAFGVSISISNYVMAIGSPGNNGNSLPGRAYVFEKQNYNLIQAAQLPNNNNNQNGDLFGFSISISQDSSVILVGVPYANVSGNDSQGKVYVFTKSGNEWIQTKELTASDGQTGDNFGYSVSISERVILISSPFASVNGNSEQGKVYVWEGNDNGTIWQQKPTLTATNGQANDQFGKSLSISKNSSLIVIKSQQSSSQQVTAHIFQSNGTYWNEEENFTVNGTQEYDYGGQISISEDATTFVMGVTGDDYNQGKAYVFHYNGSNWNNQTIIPNNPSGKCCFGFSVSISQNNLLVGTFVQNTAYLFQNNGSGWNQERQLFPHNPVNAGEFGQALSISEDIFAISSPYLAYDGFDNVGGVYIYEFVYDQVNLLNCSSLFSSFDCYWNEILPITSDIEYQINYNYNNNEQWETIQSPILIDNIFFQIFNSSIYPNITGNVDYTIQIRVCNSTSQICGESSDPFFLTTRIDSVKNFTLESIKATSVMISWNSPNVPVINSIPKLDHYLLFYQKQDSNETKNVSISNSSTSYELTELDSLSNYSISICGCETYECLGNYQGEIVSTTILTKFGPVLNLQCSISNSFDISCYWDKPNDSINPSYYNFTYQAISENDNGNFDTNSTSQNFTAQYSNQNYQINVSACDLNEICGDISSIQIGNQQTSSQSSNSKTVIIVCSTIIPVVFIVGIILMIVLIRKKKKKKNREEENLISHSVSKDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDI5</accession>
    <name>A0A9Q0RDI5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDI5"/>
    <dbReference type="OMA" id="IGCEIHS"/>
    <dbReference type="OrthoDB" id="18783at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="695" mass="80573" checksum="F5F505DB97B06F6A" modified="2023-09-13" version="1">MLLKNFSLFLFFYLIFTNFLSFIYTTEYQDPKISYEIHSSNDLRQWNSIFNKIQNRKNEEHWIKIDLFYIPKNNYNNFPQCNQTEENGCLLLTHNFPIKGVDYNTTEHLLNYISDKNNQEKFRNSQEKIVIVLSNDLINSQNLNLEFILDGASTPGGALFDFSGERTRKCLAEKWSLWNSTFISIQDPIEIAFSDENYFSRFQILNEFITPFHSTFFIDYFKKFDWGKFQQTNYPFLFWEPSDQEIIQSVEKSYLSGKKHNPGIRISINIDPIQFEVFSANYTGIAWNRFVSPDSIDPHIIPINYNFTKNDVPQEISFMVLSKNANQTLQFNSFSSPNFFNNEINLISTGEIQNYTQKMDHVSWISLKRPSSSFFSLNQQETVFSKYFSKDSSQILVLISSFDGKNQPFHFNTDDFSFFQINQSNLNFIGSTKISVVHALDSHILQFYIPEDDESTLLFQLSDLYFHWDSKMHLIINNTKHTPKVALIDLPLNIQHISVSAIYDLSNHSLIHFFLTFSTIDSHLFAVVGTISTKTASITNSSSLIPRFIGFAKSSQISLLYLNQSLYCLMLNSQGVCYQNEKKMKNGKIKICDQKGELGTNALNYAIAPFQNWQIFLKQSDQILNVCSEQILVGTYDIGKNSHGFFTSSKKDDLIVLEVHEGISKDEICQNCEGCGEPYFLKGIILDSWKFSFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE16</accession>
    <name>A0A9Q0RE16_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE16"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="257" mass="29510" checksum="E9DCB568DC0A40CF" modified="2023-09-13" version="1">MTTPIHIKVIEAKGLKSADIGGKSDPYYSVSINGVKPFFKSKTIKGTLDPVWNETHVLNCKNDQLNSAKIIVGISDWDRIGAHDLLGFIRINVSTLLSGEPLEKWYDCEGRKPGTKEKVVQQVQVQQQPMVMNQQQQQQPMMMNQQQQQQPMMMNQQQPMMMNQQQPMMMNQQPMMMGQQQPMMMGQQPMMMGQQPMMMGQQPMMMPQQPMMMPNQPMMMPNQTHISHKDKKKHKKEKKGLGKQLKKAWKNFGGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REE8</accession>
    <name>A0A9Q0REE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">24-dehydrocholesterol reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REE8"/>
    <dbReference type="OMA" id="LWICPLR"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="451" mass="52723" checksum="FDAFAF555BA81405" modified="2023-09-13" version="1">MEDLYDFTITYGLIPKVLPEFKQITAGGALLGTGIESSSFKFGLFERTVTQMEIITGEGSVMTIDKNKNADLFYSFSGSYGTLGILTLLEIELIEAKPFVQLSYHKITDYKTAVDKIAQISKNTEIDFLDSILFSRRNVIIMEGKMVGEFPKNSTFSKNSQKNFPSLKTQNTNNKQTPQKIKPTLSLRYFWSKWFYRHVFFVTNIDSEKEENDKGIVHKDFLPLKDYIFRYDRCAFWMGTFLEKDTLKYRLLLGWLRSSYVLYRMRKLWTARNFEEKLYTHDFIVPHENVEGFIQESIQKMFVHPLWLCPVTTNTSNVENDQIQNIIFSISDSRNKINQKKNSNLGKIQDDLFVNVGIYGLPDVVDFGVPYRECFDIVNKYMENFACFLNAKKFLYGSSYYSPQSFWRCYNKNVYDKIRSKYNAHLFPDIYQKIGNCGLRSKLSNLNKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF89</accession>
    <name>A0A9Q0RF89_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Klaroid isoform a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF89"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040202430" evidence="6">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="172"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="343" mass="40665" checksum="AD572FD2A9CD7982" modified="2023-09-13" version="1">MKIFLWIIWILFFFLTPTISQEINENEKIFEQLKEELHNLNETIHQISAKIKKLEPNQFLEKILSWENLITKKWNKLKMSHKTFIIEILLNLAHEKEQTENKMSKLSRRVIQELFEKNQENEEEFEEIFEELSIILREKYGFSEKEIKMYINKILDIINWEMIDKIDYAAEGHGGWIIGSSPSYIPEHNNKWINFFFGYFLAQNQISLPEYAIQSNTHNKRCWSFGGSYGVLLVHLSKEIQPTHVTLEHLSSKVTPDYTSAPQEFQVWGFQSSQNLFSSPIYLGRFVYKIHSNSSAIQIFSIDQKNLIDSIKIIKLEILSNYGKEYTCLYRFRVHGIPKKKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFK3</accession>
    <name>A0A9Q0RFK3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar complex 2 and rad4-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFK3"/>
    <dbReference type="OMA" id="SICAFHY"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="701"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="717"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="824" mass="96240" checksum="50C14FEC3E4D842B" modified="2023-09-13" version="1">MNKKNKFAVIENENEIENENENENENENQNEIENDLENEIENELENEINDLENENENENENEIENELNDLESDSESDSESDLNENENELNENENNFQFDFENQNSKQNQLFSHNALESISDSDDSEYDMNNPDLDDLEDSDQEGENQQYPKPINPMLTDSQTENSEKENSGVDFSKLKFLNSEDLEKWKKIAPDSKIMPKNLLKELLQIYFSICAFHYQPDKQIPSKELKFKVPKKEQKKEQKSLLEKLNIKPPQFNFQDPKLFFDFLLFCVDRIVNFLDKSINYESDKWSLLGPERVSTLPQNLPNFRSIKGLTKVIVSYTIYFLNQPSESSVKEYILSQIDLHFLPYVVCYPNLREILLNSLLKIWEQDQKNQSKAFLIIRKLAQFISINFYEKCLKKTYKTFMNNCHFITSLNVNSIYFMMNCVTDLFGLDTTTSYQHLFVFIRQLGLILRKAINDKSKKSKSSVLNWQFISSLRTIIQIISKYPDSTLRELSFPITEIAIGVMQLFPSTIHIPMRFIIIQSLNILSRCTDSFIPVAQYLLSVFESSELKKRAKLNQPSKFSLTNNTILHVSKKETGNSYFQENSIKQALRLLLEHYETNSYRISFPELAVPGIYILKKFSKNTKIAKFAIQVRQFADKIKENVDFVKTNRDKISFAPSNSVLINDFLSLEKKLRSSPLTQYLKHQINLQNAKEKFLQESSNFSSEKQESNQKSLKKSNQKSLKKSNQKSLKKSNQKSLKKSNQKSNQESLKKSNQKSLKKSNQESLKKSNQKKRKSQKNSSKIDLQKKLKTKKNSSKKQLDFQQLKNLKDVVEEMDLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGA0</accession>
    <name>A0A9Q0RGA0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein rcc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGA0"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="171" mass="19553" checksum="90E29A3AAEB833F1" modified="2023-09-13" version="1">MNEILFFGQNHLSTLLKNEPKIIFKPIHINFVDKDGNEIERKIKKISTGYFSTIFLFEDGEVIEERRSTETSRIEFSNIKDVEIGYRNQAILTYEGNVFAKGKDINPENPNEFINISSLIEDPNGRIIQDIVCSSQSIYLLNSKGNAYGIGDNLYGQLGFDSFKKAQKNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHF4</accession>
    <name>A0A9Q0RHF4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHF4"/>
    <dbReference type="OrthoDB" id="1661883at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="647"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="682"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="716"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="750"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="784"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="818"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="852"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="886"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1136"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1252" mass="146380" checksum="A3C068F414DF465C" modified="2023-09-13" version="1">MKQENYLKTVYQAIKTKNVHFFNLSLETTEQFEKENKPFLNYAFERNSNLEMIQKLIDKETNVNWVDQNGNNSLHIALERKYPKEIIKLLISKGSDINSKNIQKETPLHIALKNQNPNEIIELLISKGSNINSKNEWNETPLHIALKNKNPNEIIELLISKGSNINTKNNRNEIPLHIALKNKYSKEIIELLISKGSNINSKNNENEIPLHIALKNQYAKEIIELLISKGSYLNLKNNRNEIPLHIALKNQYAKEIIELLISKGSYLNLKNYENEKPLHIALKNKYPNEIIKLLISKGSDINSKNSWNEIPLHIALKNKYSKEIIKLLISKDSDINSLNEWNETPLHIALRNKYPKEIIELLISKGSDINSINDWNEEIPLYIDLEDHYPNEINELLISKESDINSKNNENEIPLHIALEKSKKEIIELLISKGFYINLKNYENEIPLHIALRNKYPNEIIELLISKGSNINSKNKWNEIPLHIALKNKYPKEIIELLIFKDSDINSKNNQNEIPLHIALRNQNLKEIIELLISKYSDINSKNNQNEIPLYIDLERNYPNQIIELLIPKGSNINSKNDQNEIPLHIALRNKYPNEIIELLISKGSDINSKNNENEKPLHIALKNKYPNEIIELLIPKGSDINSKNNENEIPLHIALERNQNPNEIIELLISKEFDINSKNELNEIPLHIALRNKYPNEIIELLISKGSNINSKNNENEVPLHIALKNQYPNEIIELLISKESDINSKNNQNEIPLHIALQNKYPKEIVELLISKGSDINSKNDWDEIPLHIALERNYPNEIIKLLISKGSDINSKSNRKETPLHIALERNYPKEIIKLLISKGSDINSKNNQNEIPLHIALKKKNPKEIIELLISKESDINSKNKKNEIPLHIALQNKYPNEIIELLISKESNINSKNNQNEIPLHIALKNKYPKEIQIILMRDLNIFDLKENEITQEMIDLFPKVYSFIDDLNNFLKSNEFTDIEIQSSDGSIIKAHKQILLVRFDNNQTILTRFINICRRKQKRDIEFALNFLYTGFIDFDKFIEKFNDQFIQKKAEIDPNFKFLFSNEIEFEEQKKEQELILNEIENKNEFEKGIIYDLFEKTGFDLNWIKEKEGRKGILKDFEKFYQQNQTKDFTIIVEEKEIKVHKLILQIRSELFKGMLLLNVQDQSNQVHDYSKKSFETIHQLIYFLYHDEIDKTKITQENIEEFTDLKEFYQLNQKSILGSYLLDFYSKTFSNNQNQNQNQNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI33</accession>
    <name>A0A9Q0RI33_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI33"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040414349" evidence="1">
        <location>
            <begin position="28"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="612" mass="69468" checksum="C5D18BB0BDCAA5DC" modified="2023-09-13" version="1">MLFKFFELNYLFTTLILILLLINPIKSLEGICKIQKEFRIGDNTTQSQRYPKIFELQQDTLGMFWIGYDSDNKTWEIYNQLYAINGTALNSEKKITINGSLDVTKFEATQLPSGEIVLVWEAVLSRSPYTYEPFLIDAIDNGNFAVLYADISGSINQTYAQTFDNTCQSTVAPANLFDITLYDVDSLKIASGHDGILYFGYTINSTANTGGIKIWVQRALSDLSGIGNPEYAGNAISCFQMDLFYWGNSLVFRVGKYISNSSIDFEIVQYFPWAHLTVQTSISPMVYNPRFANFTEDSFVLIYENYYADGSANGIFGIVCYKNFSFTLRYDQFPVNTYTESNQDSPDLLVIDNQILVVWESLGQTGNPFDYSIYYQLLEPRNVTCNTPTLSNYTLKMNESSSYQIPNDLCVYVNPDSINFTISVNGNTSLPDNYSFNSSTNTLEFTIDTILASDLVSIKFELLECNFSQTIMPNLEFYVNFYAEINQFNSSIPEQDILIYSPISYKLPTDFFTFFDNKLLNYSALLNGSPDFPDNIYFNSTDNSLISGGFSEPNFFNFTIIASENIFGNSKNISINFNITAPETSENQESSTSNFVLNFSFILILFEFVFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RIB1</accession>
    <name>A0A9Q0RIB1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ring finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000004">
        <property type="protein sequence ID" value="KAJ5080683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RIB1"/>
    <dbReference type="OrthoDB" id="17995at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="575" mass="65501" checksum="8AF52E1949A20EE2" modified="2023-09-13" version="1">MRRRQTNKRYTQNKVNSYNNYNKNAEIEEKSNALNIPLEIITKFHEIISKEGEIDSKSQIQMGSNELIKLIKELQSQKPSIYYINEKSQYEGTAYKKHTEFRCTFDILVLQVPENGWISIELLDQSAAVVSSKITFLQNEGLKSEKDDTNTNEQNSSEKDLQANIAINGHNHCLITNLEGRYKVDVKFLVPYISDKGCSLNVVVPVCVENSLRFIVRGKEEVQINCQQVLTQSQTWKVDDESNRTQILDNKETQNNSVHELKGAGVTIMEAVFKPSSYEIDEKIEFEIVEKNKIVNAQQEIIHSIGEGTIITTAMYTFQIIHGTMSQFDILIPSIEGESKFKILSVNGENINDWEVVDLEEDENEKDGFIDNQDEDDANNLEIDFDSNKNNENLDSNKNNENLDSNKNNENLDSYKNNDNLDSNNDNNILYNILKPSKKLRIFLKFGIEGFYNLTIVTELDTKNQSCKSALPVFKTLGKINRESGFIAIEARTNVEINEVAFKNMTKLSVDELPTTIVTQSQGSILYGYQFTKPNYGAIIELKKHDDATVLIAVIEEAHLKINYILAGRTARDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RID3</accession>
    <name>A0A9Q0RID3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RID3"/>
    <dbReference type="OrthoDB" id="200415at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="285" mass="33930" checksum="1DD6BBB5FB3B67A6" modified="2023-09-13" version="1">MESKNLIKIASFNVHMWSDRDDTFSIERFKKTIEKNLPDILCLQEVVCPFVFPIYDAIDQQQSEECEDALKYLANTFGMEYHFYPSYQSDFGNAILFNKSKLKGEQILYKEVSSKKNDKRSFGVVSFDFNSFTFDVCCTHLDHISEETRLKQLDEIFNSFKENQIFEKYHFFVGDFNSLSLAEDYSLQNWEKIEKVRRKNFWELPKLDVYKRITQKENYIDCWKKIHPEIKDEFTCWAQTRIDYIFASQKVFQTESPFKLLSSYSINSNASDHKLIISEFLVDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5F1</accession>
    <name>A0A9Q0L5F1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endothelial differentiation-related factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5F1"/>
    <dbReference type="OMA" id="KANQQRS"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="141" mass="16154" checksum="6E871BC651BC063B" modified="2023-09-13" version="1">MDYQDWNPVFIGNKKPEKKPEPTKKEKEKTKEKELKRAIKSGNVIIEKKRDAGKNAAKKQDVNMKNVEEAETFETKNVGLKLGKKIQQARATKKWTQKELGMRISEKQSVVNEYETGKAVKNNQILAKMEKALGVKLRGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5S0</accession>
    <name>A0A9Q0L5S0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5S0"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="215" mass="24616" checksum="17CC3052921D9732" modified="2023-09-13" version="1">MKILKAIEENNIKYLNKIEKIPNKPLKKDKDKKSILHFAIEKQASQEMIHLLIEKGIDINSKTNLNQTALHFACEHQNPSFETIKLLIEKGIDINAKTDLNQTALHFACENPNTSFETIKLLIEKGIDINSKIDHYERNALHFICENPNLSFETIKLLIEKGIDINSKTNLNQTTLDILCENPNSSFDIIKLLIEKGIDINSKTKDKRTAFTFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6A7</accession>
    <name>A0A9Q0L6A7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6A7"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="602"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="712" mass="82549" checksum="6F3ED527AEC04229" modified="2023-09-13" version="1">MQKQIRMKLELILIQKQIIKNETALHFALQNPNSSFEIIKLLIEKGIDIKGKVYWYKTPLHLACQNINPNSFEIVKYLIEKGININAQTDNGLTALHFVCQNPNPNSFEVIKLLIEKGIDINAKKRYNETALHFVCQNPNPNSVEVIKLLIEKGIDINAKKKGNATALYTICEEANPNLRPSFEVIKLLIESGIDINSGGGFIRQTPLQILCHKHNSPLEITKLFIQKPRDIASTNDLNIFSFYTVCRYSNSLELVKCFIESGIDINSKTKYKRTALHFACENINPSFEIVKLLIEKGADVNAKTSDNETPLHCICKSSCSSSFKIAKLLIEKGIDIHAKTINENKTALHFACENYDQSFKLIKFLIEKGIDINAKTNENKTALYFACEIKELSYKVIKFLIEKGADINAKATKSFYQTPLSILIDKYRDDLVELMLMNNVNVLILEENRITDQFIEMFTQIYSINQDMNQLLNSNENFSDYQIQSIDGFKFNVHKLILLTRFDNNKTTLEKFINICSQKSKEEVQIALNFIYTGFSDFQEIYQNLKERTTKRIIENQKEKENKVEEFFKEIGFDLNWIELKKGRNGIIKDLSKLYQEESTKDFTIIIGDEKEKEKEKEIKVHKLILVLRSELYKGMFLSVQDSSNQVHDYSGKSFETIQELIYFLYHDKFEKKTKEISNEMIKELKDVKDYYQLNPNSRIDLILKRLISWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6D0</accession>
    <name>A0A9Q0L6D0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6D0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="371" mass="43527" checksum="484573C82F99BC30" modified="2023-09-13" version="1">MDPQLLYCGIDDDNDFDLKNKIYDGSLIPVDQQRVDDVLYKFRENSELVQNQINLYAQTKSDPSLLSFPHFCILNNQILAAEYEIVSRTYSNLFQSDFYVDVKSNNGNAINIFTRLSFPPNIERVVRNLKNIWNSHLLLTHHLALGMENMINHDFQDAFEFFGFCFKNSSLYFGDFSRISLVVQVFVLIVFDESERIIKSLNLDLNNLENNNYNEKESILIDLSVRIIEFITWLYNYSLDYSNRHKIPQNSIFFMLKLKDNYVNFISNQFQIISEKIELNPEIIQFVDSNPFLKKIFEVHQNSGQPTQVISPNFPQKAKMDIESSSLYKLLQEKTQEFNSLFQSQISTSNLMIQEFPNAFKLKIKKLKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6J1</accession>
    <name>A0A9Q0L6J1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6J1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="74" mass="8772" checksum="A51A799D4636CB80" modified="2023-09-13" version="1">MENQISKSIQENQNNILPVVTLSNTQFLENNSNEAYKILNFYLNLNQIYENNQESQLKENEISDILIPDTKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L769</accession>
    <name>A0A9Q0L769_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L769"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="261"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="590" mass="68878" checksum="1CA396C75863D763" modified="2023-09-13" version="1">MIVYFLVKIKTNSYKNEPDEITKPIQFKFENENENENEKQIKQISTGNYSIIFLFENGKAIEYLRYPNPNQNPSKIQIKENIQKVSVGYENEAILTIEGNVFAKGYDINPKNTNEFINISSLIEDTNDRIIQDIVSGYNSIYLLTSNQNVYGIGLNQYGQLGFDPKKLPKTRKPILIMKNVSKIFSGNSSRHVFLLNSNQELFGCGNNYSGQLGLGESRKEEEIQKLTKIQNIPKGKIIDIQCGYFHSIMLIENENQNPKRKLYSTGRHGYNGLGKNEYTYEFTEMKSSLFENDDNILDFSCGNVHNLILTSNSKLIVFGRNYFGELGTGDTNEQLIPIQIELPKLRFNENISNYHISCGYNKSFLYYSPSLYSFSNLEEDLIKLFERKEFCNISFKTKNGEIISAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITQEIINEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7B1</accession>
    <name>A0A9Q0L7B1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7B1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="482"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="587" mass="68394" checksum="7493B3629E8DDAE2" modified="2023-09-13" version="1">MNEILFFGSNKNPILIKNESDKITKPIQFKFENENENEIEKQIKQISTSNFSTIFLFENGKAIEYLFNQNPSKIQIEENIQKVTVGFQNEAILTIEGNVFAKGKDINSNNPKEFINISSLIEDPNDRIIQDIVSGWDATYLLTSNQNAYGIGSNQLGQLGFDSETLPKTEKPILMMKDVSKIFSGNSSICVFLLNSNQELFVCGDNEYNQIGLSKSRKGYIDKLTKIQNIPKGKIIDIQCGYFHSVMLIENENENENENQNPKRKLYSTGDYRYNGLDKNQNARKFTEIKSSLFENDDNILDFSVGNAHTLILTSNSKLIGFGYNYSSQLGTEDTNYQLIPIQIELPKLRFNEDISNYHISCGFNNSFIYYSLSFSNLEEDLIKLFRRKEFCNISFKTENGEIIKAHKLILKYRLNQIQNEIEKLQEIISNKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7D0</accession>
    <name>A0A9Q0L7D0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Wd-repeat protein interacting with phosphoinosides wipi -related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7D0"/>
    <dbReference type="OMA" id="SHYIGIT"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="274" mass="31146" checksum="91EB80754D30FB9D" modified="2023-09-13" version="1">MNRVFEQTGISKCQILNRSNISIFFGDGSSNFVKNDEVFVWDDDMFQCVHKFSVGEPVLNIGIQLTFIYIVTQSKIFAYETQNGKLIHDIETYLNPKGLLSLCGNSSLSIIAIPGKKSGNVRVIDCAALNKLDQEFTAFDHEIQQIKLNYDGTKVATASEEGTLVRVFDTTTIYSISFDLNSHYIGITSSSKTIHIFELPDFNQQSNIKKRKEGTDRSIMKVKIPSQEYSICGFDKKGYFYIVTKSGKFYQFQIDFQQQKMTKKSSYNLHSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7R9</accession>
    <name>A0A9Q0L7R9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7R9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="339"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="533" mass="63871" checksum="C655AE9A53A39583" modified="2023-09-13" version="1">MDNNNNQIENANQNQNENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIKKRVKSLKLKKYKHKMNAKKRLFHSFFSLFDKDSISKQDFDKLKQFDIFLPNSFLIPFERTIFEIQDKKKDKKIENKEKENQKMKKEIKEKWKKKVAKMKPTFHLFRKEFEQLQKIFADSEIIKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFSSQNWHKAVDGKGKTLVIIKTEDNFIFGGFTQVGWTNDKSKWSGIYENQDYDFIQDQNAFIFSLRNDKGDRKPEKFRIQQDQEKYAIYYRLSKYGPYFGGKKGFLNCDFFLDSSLQSGYSNFGITFCLPNGIYYGTTESRSYLSGSYNSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8A1</accession>
    <name>A0A9Q0L8A1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase ubr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="30336at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19674">
        <property type="entry name" value="UBR-box_UBR4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045189">
        <property type="entry name" value="UBR4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21725:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="7">
        <location>
            <begin position="1578"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="1578"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1536"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1670"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2222"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2269"/>
            <end position="2396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2411"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1369"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1540"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1686"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2228"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2272"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2292"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2319"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="2353"/>
            <end position="2371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5067690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2825" mass="331468" checksum="0C73B4DDA3F4F071" modified="2023-09-13" version="1">MDKEFSNLLTFAVLLANAKNELEEQNQEELQIYLKEFLQELKTKKKEILNNKNFDQLEKLVGMLNYFLDTLSKNNFALSLSQSKFIAYFLNLWSSVLFSINWENLKIDFSSQQSNLIFQSFDSIFNFCFTYFKNPFDNKESKQQDIQLKNKIRQLFIEILSNLSFCSFEMNTEKNITNLVKTTESLEIPKFDFSINYEPAKEVLHQESEPKPEVISLIEQKTIQQIPPDQNSFLLGLIDGKVAKYGESQTQAKEKEEDAMEISPFINLPFLKMHSSSILEDQIKNLLADCVFLIQNTKDEKDLPNLSTVIKLIQLMQNLDNRIVCDAHIAQSLFSILDTSMNGFLEQQLMFKNLIEKILNFIQNCFPDFLSRNLHFVISYKFIGKLNLLASQFQTPLKSIEDFNPIQQSTGLTIDQIDFYFQSLNALFHKQPKKDSNDSLQKHFQFSLKTYTQTKEKSNLIETENNENNSNDNLQKFKFDYLVDYEDRLLERLIIDDISKTRFLNSLFGSILIPYFHLIANINNIKEIKIEKEKEKPKEKLKPQISDLRSQLLKQIRSKKSDKKDKKKQKISYEDEDEDEYGIELQSIFDNIADTQDQSLSNKDHSAEMHINSLENILQFCISILTLSNLNISKEKVIENFRHSMNNFHVDTLLKLGSFFSDQLEKIKNTKLLVLSRKMNALIISSSIINEDLSQYLLKNAMNDLERKLDIPIENLSLLSRLLMKINMDSKQTNQKIPNFGISFWEHNLKVLSNTLSDTKESNSEQIQKLWSLEQVKLLLLLFDMIDFQSQKKIVQDLIKIISQIVDQIPKLQSQKLHLLAKVLLVFNHLLINAGSEFSNSFYLDLNVLFSIDLVPIVSKDGFFSIPLKQENQKKNQIHKEIQELCQKNNLQSILWKICDLNLNLNLIYDEKQTERNRIDIYYFQNCWDLMKTIELPINKETISEYLVYISKFDNFNEISQFIFILNSTLLNLHMVPNEDIANLFTKLIDILNSIMQFYQKNNTFHSLQLISSIIFFLHSQIPLVSELEHFQKFGIDSKLEIEEQEFLQSKVICSSLFLNTPELFGKIINCFIQLQSFYLGLFAQQMQLVPITILPILDEIWRIDLAKNEMEKLLLEVIDKQTVNKMISWCEFEPNIKIEKVISKNAEKQFYYDLMVHMENHRYEKMVFSLQYNLMKFAHLISEIFSILLSKELETEKKKQDFILSKEKLYQILTKMATDVRFLKLRGFCDEKIQLIEKESKFEYFQIQAISNLFNQMKLSISNYQSMRNQNQNQNSLSEQELIQNLFRITDKSIVHSFKTISAIIVEQKKIPPLKMIPDFSLILEISNLSNSFKDQAYKLLNEISKIDDKPFHQNFINSFSKITDETMTKILRDNLNLENKIIEEKENEQNKNQNEVDFIIHLASENEQIFNLFLSFIEAKSFLDYGNYFNILHQICLLDESGNRTLQIFDKSCGIVTKYPIDISLLDFHQLNKLKLFLRINVEIGEANQHIWKKKTKSRIKQIDEKDQEKEQDQEKEIFKNIYEEKDDDIWESGNEEIDLKEKEQEKEKEKEKEQEQKEKEQKEQEQKEKKTQGDDICTFVITGRNREHQHYYHCFTCGLTGDRGCCTTCAINCHLLKGHDVSYASFGSFYCSCGDELRQNCESLQPRSVLSKLEYITHKEQRLKFKNLGDQEENNTNQVGIKSKNKKQKQKKKRKTKKKREKSKDEMKLQTKFREIVMKNEILKQYLSNFYTNQKNISEAELFLTKFIGNYCEDLYCKKEKDQLLNEDDDYDFGGGIFPEKNGNQNGGCSFILKKFQKSTIFNPNSCFNEGCFDMELETAERSQVFEFLVKCHILQRKVLSSLATGQLLIGEKSNLVILDANDIVREKQNLPLEKEKRKNLATSNFPFEIIQIQPNKVYSGYIALTGLRNCSVIEIDDKMNIVKNIPVELMLETIGEDLFVIHAQWIPDSQVKIGIVTNGFVKVYDLSKDTLSPIHYITPFDSQICDGLFLKSKKDSQIYAFISTMSGKLFVQKLTPVSDGGACYLTQEIQIPSKLQTDKNLHIDYCAENDLLFCNYYGIENDENQDSKQNNYCFVGKINSNLDGFSQITPLYEDVPDNCQKYTPFTRFEKLPNYNDLYFAKSHSDVNVVAFFKFEKEKVLINIIRNSPNGRIIGISPMPNLLSNFTQKNEYEEDEKISDFTFGLQQKPEETKDFVFVLSSTGSINLYELSPKFSRSKNIKKKKEQIQQKAKEPEKLKEVKQDDLFDPFGFLGDDNNDQDINIQIQTYQDEKKKDEKRIKSKIHKDLSESETSESETSESESESSETSETSETSDSESKSKSKSDSDSDSDSKLKPKLNSKLKPKEKSKPKQKFKFKFKSKPKLKSKLKYLSGSDSDSDSDSQPDNYFGAIEKKMKKMREMKEKIRKKIQEKEKEKEKEKEKEKEKEKEKEKEKPLKSSMKDILQHSSKLNLLLPTKEIQLPLNYFEKFIPTPLQEFNFSGSFTNGIPQEAFAKKLDKKKTFYISKKPSKQQKEYELVITNQNPMKVFVGLRILLGKYNPDCIPKTIQVLNRKINTKDQVTKWYNFGLSIEESIVSDHSLVIRISNCHVPKNEIVIDSLEVFTITKEQFGWAEKMDEIKMKISEKNEENKTKKQKKQNLYHYFGYDSYYFKKNQMEKFSNEKNQDEKKLSLKLKSRILYNYLVLFSLMKQEAMEANENFQNELFRILGCLELKKCHEITKNLLHQLIKSKEEYQKQKIWFLLEVFSQYLINNRIGIRNFELYCLQIGKIYWKKRQDLNKFLIQHEQLIEKIWEKFNQYQNHLKNKEKILSILILITLSFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8U2</accession>
    <name>A0A9Q0L8U2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic fmr1-interacting protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000119">
        <property type="protein sequence ID" value="KAJ5068208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8U2"/>
    <dbReference type="OMA" id="HKESFFY"/>
    <dbReference type="OrthoDB" id="10265867at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008153">
        <property type="entry name" value="FMR1_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1272" mass="148459" checksum="DECEC9E620D2AB6C" modified="2023-09-13" version="1">MANNQLTTIFDQLDLFPFEDNTPHIESGEPTIYYSTENSLQFFDKNAYKDSPVLEDMIMIEQFQETARLGEELFVKLYAHRSITKTIINAFNEAKFDTQTKSDEVHRKRMDLLKPLFNTARKLIKFRDETTDYICDIVRRMVSSKNRVVFQDIIEALGVLIDNYVLLDLLLNQKPSFANDFSQYKREFSFMHDDDTESANITEEMHLISLFFANKYSLLTHLKTKIQEIEQTASVFEVIINHYLDLFLNQSYILPNEKNRQVRMIATCLILLDDPKNEKKNPFKSKSIPLTKIGKIFKQQPFFLLFGDMSIKIEEYLQQAPHFSTVIWGSLEDKKTIQQYLLTNYLTQERKQHNSYVSEFTQKINSIKTQKANLENLSRDQRKDVVELVLRGIRLISSWTSKILEQAAYKYTHATEDAKCPLGATDYERVVRYNYTTKELSTLVEFIAMVKGLSYFMAKHDYLISTIFRSFIYEEIQDFVQNTLRPSIKKAAKNKKKPQTRDKLLLIRTLFADWADEKIPNDPAVIGKNYKNTFQILSKSAGISKTQLILLRLLAENLLFSLGKKGEVIKCKEISAKAVKAIEEFLHKTLYFQYLVNFSDIVYESSNLSHLWYREFHLELTKTIQFPIEMSLPWILTHHALSMRSSYVAEMMLFPLSLYDDSCDCAVKILKEQFIFEEIQAEVNLCFDQLAFELAESMFLHYKYWSSTILLDKEFRAEIQKLKTASNELNPPKSRYHILAVQRHFSLLGRTINLNKLISQKMNNIIRENINIAIQRFESSNISGIFLLEELLKNIKMTHFLLSQHFELDEFDTIFNEINESISLVSLQGRIVLHCIFEFIADVIPNFVYNSTTQRFTRSPRTYAEKVVRDAPPRIPPVFLFGSKFLNDSYESIADLKSEFFGIPHILSILRIIGEQNLPLIAQECLTNVELKIQNVLAPYVEELLNGISTKTNLPSIDYGIDGCFGYFELPLDPIRKYGPLESEVFQNFRELGNTIILMRLFEQAMTEPHLKTFINSAPFLCLFPDKFSFNDDDDNNNDNSDYSNLINFQNKNSRSISMVTSQLQKILANPEFSQDFIPIRDIENFSQNTESVYKIKSKPLSLFKAVLMHVNKMLDPVRSKWLGNFQPGLINFDRSNEFYRLWSCLQFMFCLAPAEENDENENENENDNDNLFSHQETFGDGFSWAGMTIIYFLNQKELFNSLDFSYHLLYANDILKEKAKSVEQTYFLDNAKYLRDLNNLIFSFLDSYVPLPDPQIQFFEPPTEEELQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8X9</accession>
    <name>A0A9Q0L8X9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pyruvate-flavodoxin oxidoreductase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_13183</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8X9"/>
    <dbReference type="OMA" id="NDDINHT"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03377">
        <property type="entry name" value="TPP_PFOR_PNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000012">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000041">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.920.10:FF:000001">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="entry name" value="Pyruvate-flavodoxin oxidoreductase, EKR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050722">
        <property type="entry name" value="Pyruvate:ferred/Flavod_OxRd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154:SF0">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="699"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="755"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1204"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1204"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1227"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="708"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="711"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="718"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="764"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="832"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="857"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5067223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1243" mass="138975" checksum="F8B07BC46800DBA5" modified="2023-09-13" version="1">MLKFAKNFKPKSNLSLLKMFSSKKPMDGNTAAAYVSYFLSDIAFVYPMNPATMMGELVDKWSAEGKKNIFGLPLQVNEMQSEGGVAGALHGALAGGALATTFSASQGLLLMIPNMHKIAGELMPAVIHIASRVVGGQALSIYCDHSDVMETRLTGFAIMGSGSVQEVMDLGFISHLSTLKASIPFLHFFDGYRTSHEVNSIDVVDRELMKKMVDYEAIERHRARSLNPEHPHLRGSAQSPDVCFQAIEALDQYYKKVPYIVQDYMDEFAKETGRQYHLFDYVGHPEAERVIVVMGSGSSPVEEIISKNSREKIGLIKVRLYRPFSVEHFLTALPKTVKRIAVLDRVKENGAPSQPLQSDVMTAVYGRNIDVVGGRFGIGSKEFTPAMVRSVYDNLGQLNPKNNFTVGINDDINHTSLTYGPNIDTVPDGTKQCIFWGIGSDGTVGANKNAIKIIVENTNLQGQGYFSYSAHKSGGVTVSHLRFGPNHIESSYMITNSDYIACHQKHYLEKYDSILTPAKKGSKFILNSPWNTIEELNKNLPNHVKREIAQKGLEFYNIDASKIADEVGLTGRINMIMQAVFFKLSNVLPEEKSISLLKKAIEKEYSTKGGDVIQKNKDAVDMGIKNIIRIEYPNEWKNLPTESNSLLISKRDTDEPEFVTEVMRPIMEMKGNSIPLSKLAWTKIPSGTSKYEKRGFSDIVPKWDPQKCIQCNLCSLLCPHAAIRPFLISNEEKNNAPYPDKIQTLPTEKSTVLKFALQISPYDCTGCSICSRSCPEQCLEMVPSELMKPKHGENWDYMVKLPTKEGIYSNKTIKDSQFCQPLLEFSGACAGCGETPVIKLVTQLFGDQMIIANATGCSSIWGGTFPLNPYTSNQLGHGPAWGNSLFEDNAEYGIGIAKSVNQLRFKLLTYIKGFLDRKVIKDYKLNQLLEKWVTSFDDRELSNKYSQEIQKYLEKRPKAYSKSTKESHEACDHIWKNRDLLAKKSIWIQGGDGWAYDIGYGGLDHVLASGEDVNILVLDTEAYSNTGGQSSKSTPRGAVAKLAISGKQTAKKDLGMMAMTYGDVYVASICLGADPNQAIKAITEAEKHKGVSLIIAYCPCIEHGIKGGLSESVPHSKDIVKKGYHLLYRYNPILLEQGKNPMQLDSTKPEDGLEDILKTETRYESLRMTFPEEAKKKQEKLHQDIQRRYQRYLSFKNQFSKMLKDQDSEKKTTIKERPPIIRDPFISKTQFPSFSKMRNQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAD2</accession>
    <name>A0A9Q0LAD2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Grf1-interacting factor 2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34008">
        <property type="entry name" value="REPETITIVE PROLINE-RICH CELL WALL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34008:SF2">
        <property type="entry name" value="REPETITIVE PROLINE-RICH CELL WALL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="426"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1492" mass="168662" checksum="4AD3B45F98FD5712" modified="2023-09-13" version="1">MAEIAITGAFKTIMFVKGLFDTYKSNERERKRVLDRLNKLTPSLEFLQQNIDQAQKKYATLARLQSALNGYYAFLQAQVKRKKISSFLSSKKIRGQFETLEKALDQCRDDLSLELNIHTNVTVTQTSSTVTKIDNTLTDTQKEIKDMNQKIEMFMKQFQQDWSNPSEEFYIPKNPKLERRPTVINLKSNESYTSQFFIDKFGLDKKSGKILLDIFDIERKGSITSQEFKERRKIIEKGSVQDKASFVFKSWDLDKNGFLDIDEVKYALENAYTLIASFSFSENYGSLVEYMKSLDPIKKKQFKKEFKSKVKDIMKKNEVEKYIQIMFEQAVKNDNDEISLEEFVKYCGKPNNVTFTFLNALSETMNSFLEDSPDAFMKKIPDKLETHKKELLTRQSQSLIQKEKLEQQQKDQKLQQEKIEQEQKMKSQIQQQQQQKPPYQQPQYQQPPYQQPQYQQPQYQQPQYQQPQFQQPQFQQPQFQQPQFQQPPYQQPPYQQPQYQQSPYQSRSPKFQPNLNTPNYLVSNTPNYQTQSPKFTPNYQQPITPITPNQQYLYNRSPIQPIQQPIQQPIQPLIKLVKEYVYPNILLLASDDREKYLNDVENSIKSNGKCVVTKINGRTSTPKYDELLNFNIIFLYADYDWLDNKQLSETLKLYVESGGKLIICSAFALSTDFPNKDLVGSILDYIPLSKGVVSRNEKAKIDSNFGHKILEGVESFDGGNASFRIKTSNVNGGQILVKWDDGTPLVTQKTVLGKSGKNGNVIVLNMFPCSTNAIQTGWDRKTNGNRLIANTIYHSFYSPKIDYILPPPPIKMPNVLIVASDDRDAFLNDIKSSIQTNGNCNISTFNGRTSTPTIKELFEYDVVFLYADYNWIDNTTLSNNLKTFVESGGKLVMCSGFALSSEHPNKDLVGNFVSLVPFSKGVVSRDGPVYLDKRNPNEILEGVNSFDGGNASFRIKTSNVNGGEILAKWTDGYPLITKKVIKGYQGKDGMIIVLNIFPCSTNAISTGWKNQTNGGKLISNVVKHAFEIDISQSPKIKDANILIVASDDRDAYVNDVKSSIQTNGNYNIKVFNGRISTPTVQELSNYDVVFLYADYNWADNTTLSNNLKTFVESGGKLVMCSGFALSSQHPNKDLVGNFVSLVPFSKGVVSRDGPVYLDKRYPNEILEGVNSFDGGTASFRIKTNEVNGGEILARWTDGYPLITKKVIKGYQGKDGMIIVLNIFPCSTNAISTGWNNQTNGGKLISNAVQHAFEFGTTQIGMMPQFGMIPQIKAFKDANILILASDDRDAYVNDIKSSIQTNGNCNIKTFNGRTSTPTVEELIINDVVFLYADYNWIDNTTLSNNLKTFVESGGKLVMCSGFALSSEHPNKDIVGNFVSMIPFSKGVVSRDGPVYLDKRYPNEILEGVNSFDGGNASFRIKTNEVNGGEILAKWTDGYPLVTKKVIKGYQGKDGMIIVLNIFPGSTNALSSGWNSQTNGGKLISNAVQHAFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAG7</accession>
    <name>A0A9Q0LAG7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_12166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAG7"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="8">
        <location>
            <begin position="232"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="37338" checksum="2CDE6EA5A6334890" modified="2023-09-13" version="1">MLEQKEQIEETEQIEGIEEIEEIEQNRIKRHKRHKVIPIEYQLREIITTIEQKEEELSEPGTNGVKEILTEEERLSSQAMKFSQKRLGSECIEKLSHIVSLKSQKIQLDQKFSTKNFISRIKEKFSQNMKKGKKTKKQKEEKESKEGNISFFEVGKVCSEKYYTFKPNTIDLMSENISTEITVKERVKKEPEKFYKKEELDSLDNLQETQTVSRKIKMQQHLEAKYKKHEKLNFFETLFDSKKFSTTIDNFFDLSFLVRDGTSQIKLKKKEPNILFEKVDGHQLQTRKSNQFVYSFDYQTWKRMQKDFQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB62</accession>
    <name>A0A9Q0LB62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cop9 signalosome complex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB62"/>
    <dbReference type="OrthoDB" id="10266268at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="1">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10290" checksum="069622D74BDADE94" modified="2023-09-13" version="1">MSQTARKNFELANQIKEISEEDLYKYDADLQNTIITTRPWKEDPHYFKRVTISGIALLKMVMHYKYKNGGNEEVMGLIKGKKYGDKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB72</accession>
    <name>A0A9Q0LB72_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB72"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="266" mass="30457" checksum="E771EDE11031ED0B" modified="2023-09-13" version="1">MVSTPEMVCTIIASSLGAFGALSFIISYSILPEIRTRSRLFILTLSSCNVICEFTGLLPGFKSQTLCNFQAFILTWFFAASCCWIFLISLIYYLQICRNVDIENSPKFYWFASLFVQLFASTQGILTLIIGEPSSGSSYWCYVSGKGVEIFHYSTVWFCLISTLFLYSLVIHKIRKDKEANYPKSFQFKMLTLALVYIVTELWLAIKRITQIIHENESPGIVVNSLQSFFSPLIGFWDFVFFVLGDKFVRALLSHKFSKKKYSNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBC5</accession>
    <name>A0A9Q0LBC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mtl1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBC5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="296" mass="36132" checksum="5DFDE85F14CB1DFD" modified="2023-09-13" version="1">MLKLCFQQELTVYKFGNFWEKTLENTSSHQIFSNTMKILQESKKNNEEFIKSFDHFWESLNKVLNQYNIFQETQNQVNLAEKYFHQFENAENNKKEKSLYANKIGDRDFETKINTEINRDLHKKNQAEKRFLRLKQIRYQAAKNFKNFELKAFIECFKFIYKKISKYLQNQNIIYKKELEFLNNCDCFPTNEIENQNQHQHKHKHKLKHENRKKIQNQNENENINKIQNQNQNQNQNQNENINENQNQNQNQNENENEMKMKLKMKMKMKIKMKIKMKIKIKIKPKSKSKSKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBT0</accession>
    <name>A0A9Q0LBT0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBT0"/>
    <dbReference type="OMA" id="GQNTFNE"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="36911" checksum="EB29DAF0F3A34226" modified="2023-09-13" version="1">MSSKKQKKFISLIFDNFENLQKKEISDKKKKKELPIFSDGETISGTVIIDQKHNKKQIIEKIQIQFIGQIRMLYEKGTTHDFIKITKNLNEKNKIEIHQEYTFNFQNCQMKYESYHGINAKLDYLIRVIIQKQSKTDTQDFKIWVNNIKKAPKKNDSIKMEVGIPNSLDMRIGIEKSKFHLLDVVLGEVSYLKVKIRLKYMEVSIIKREVTGTGTIIYTESETLTKFEIMDGSVVKGEKIPIRFFLESLNITPTYQNIDNKFSVNYYLNIVLVDEENRRYFKECEIYFFRNSLDSKNKKTLFSKSFFEFSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC98</accession>
    <name>A0A9Q0LC98_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC98"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="322" mass="37318" checksum="4806045651D142EB" modified="2023-09-13" version="1">MQNINIPHQFFINTLMQFMTITGTNDINEGVAYLHQTNWCLQDAISVKALCSLRSISNSFQQPSQQQGGIDTSNLFNKNPYGKELSREQMRMTEKNDCENQYEKTNPALTKNKFDINRSGHRKKRANSDDIDFGDQNVEIQVDATAKSTEEEQHEEEITEIKKARKSRMPAKSLNEVLNGRNLTNETLEEFLAQKPAPRWKYRLEAFQKFNSQLVLGDLSYLFEHAKSQNQFDLDDNEDDQFPLDQSNSNLSQKSQQNSNHKRNLLQYEIDKAILDFFPKTSDEQKAKRNLQRGLIKYLVSDGFTYLSGARNGYFVFSKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCG1</accession>
    <name>A0A9Q0LCG1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Auxin efflux carrier component 1b-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCG1"/>
    <dbReference type="OMA" id="NMYACLI"/>
    <dbReference type="OrthoDB" id="2133778at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36838">
        <property type="entry name" value="AUXIN EFFLUX CARRIER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36838:SF3">
        <property type="entry name" value="TRANSPORTER AUXIN EFFLUX CARRIER EC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="370" mass="42692" checksum="CC9C3E8AC3FC6E92" modified="2023-09-13" version="1">MSNIYLDLVEVGISILSVIFLGFLCGKLKIIPTQFSLIYNSLVFQFGLSALLFQTIAKFDFDKIEWKFFLSYLVFIFIACTIVVLGAMLIEGRSITSVMSNLILITFTNNIVFGFPIFDSLYGKESRIYPTLANLAGCLTQLPFCIVLFEILDMKRKYRKEIVPISDSNLEEVSLTKNQQNFVKKDQWIEIDFSEDNFTEKANQRKRFSKKRLLFILIKKSFINPLMISTLLGLLYSILRIPLPKLIDRVLETTSSLVFPLALVSIGLFISQKKETKFSWKSVILYYLMKAFLYPSISMLTVFILNFKGERAQMMIIISSLPLSLLTYVLSRQYGLKESIISIEMVAQVLLMIPVFMFWITMTRQSNQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCZ6</accession>
    <name>A0A9Q0LCZ6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF445 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCZ6"/>
    <dbReference type="OrthoDB" id="446769at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38568:SF2">
        <property type="entry name" value="DUF445 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38568">
        <property type="entry name" value="DUF445 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38293" checksum="EF0EAF2668ED65AE" modified="2023-09-13" version="1">MKNFGKQHFEKFDEVELQDSNELQKEPNQEEIEIELELEEPNQIERNRKQESKEINNNDFQVSQDKLLLPKNQQTFYQKWIRPRFNKGFLSNLTSFTIFLIGLIIRASSQTHTNSNKAGRYILSMGLFGFAGGITNWLAIKMLFDKIPFLYGSGIIPRRFREIRETVKNTIMKTFFDEKYLKKYISTQLKKYIGSMHIEEKFMKALESPKISGLIESKLGTLKDRPEGFVLTNLGIDPTSLKPLVLPFVIGIGKDIIPIFISYADSAQWFDIEKIRIELDLLMTEKLKQLTPQIVKQLMEDIMRDHLGWLIVWGNVFGALIGLISSIAGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD14</accession>
    <name>A0A9Q0LD14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD14"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="242" mass="28691" checksum="6034E867BBC5445C" modified="2023-09-13" version="1">MAWLFGVKLALFIVALIILLFLFWRHHDRDRLYLLLYAPTLAAFFFQFLLAYSLDSHSNCSQLNKTMSYFIFLAVTLQPIFSNIFLFFSSEKLYRKNFLISLFLSLFVSVFFWISIFIHTTKNDLICSNFTSHGFIDIQWNRVNSHLLPSYFDLFLFSLVPFLFYRPFVIGTSFFILSVFLIGLCYFAFGQSSFISSFYLFSFSYVLFFFFDIDLIRNFGFKACFSRKAAHDIPWKDIEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDA2</accession>
    <name>A0A9Q0LDA2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDA2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="184" mass="20947" checksum="6B3D3E571A71537D" modified="2023-09-13" version="1">MGFRSFIIFSGLIFVTLSGFIVGLLSLFTPEPWLVDRKLVASILKTTTDNEKINQILNDSGLADLLMVQYRFGSIFLISTSAFVLLITFTSYENQNIIRITQALLLILLASIYLILIDERKFSNNAKLCTFDFIYIFVGFIISLCCGIGKKPEDLNLKEDLKLKEDLKEDLKENLNENESKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDX2</accession>
    <name>A0A9Q0LDX2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl hydrocarbon receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDX2"/>
    <dbReference type="OMA" id="KQDSTHK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF116">
        <property type="entry name" value="FI16631P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1043" mass="125938" checksum="B6CFA08555B75D28" modified="2023-09-13" version="1">MPQNVNSFRFREEERKFFQYQSNQKMSPKNSNQRENWRNRDQTQNFQSKNFSGNQTEKVNQKRKTQKNQKDKPKSALENSKKKSPTNRKTRSKKEDSKEDIKKEDIKKEDSKEKVISIQDLEKDSKEEIKKEDIKKEEIREEDSKKYSRFIQKKKLKKKILKKKILKRRFQRKSYKRFKEKVISIQDSEEDIKEDSKEEIKKEDIKEEDSKEKVISIQDLEKDIQKEEQIKKEEQIKEEIKQQIKEEIKKDIREYIKKELMPKLETKELNLEDIEKNIQKELNKINENTDTNKSFEDSKSKIQLEKNQQNQQNQQKQNQNQQNQKQQNQQKQNQQKQNQQKQNQQKQNQQKQNQNQKQNQQKQNQQNQNQQKQKQNQKQNQNQNQNQNQNQQKQNQQKQKQNQQNQQNQKQNQNQLKKKQNQQKQKQNQNQNQNQQNQKPIQTKSQSPKKQTNIEQKQTKPKKNNEPQYSITDFLTKSIPDLEPKKEKKPKKQTKQKPKKQETWEKKQEDVPDLEQILQEQEIEKQKQKQKQMEKQKEEENKKRAIKQKENTRKKKAQAQAKAKKDSNEIPNAWNIPKTSQLYQMSILEIQQEELRQAELQKQQQKPKTLTVSRTKAKEKARAKIKEKKMKQKEKMKQQQKSPVITSIRNDWDVQMTSKKVPKQQQQQEQPKSSKVSLKFIPSNQQDQSIPLTDIQPKLGKFSENVLSPSFQKIQESSDKKIPQKSKKEVNQKVSKDKDKNRNKEIWNQKQSDEFEQDTLWSYTTETTKKQGEEEKQKQKKLEKEKQRKLEEEKEKQRKLEEEKEKQRKLEEEKEKQRKLEEEKEKQRKLEEQKQNKKLHPLNPRQEFLNWCYQKMDSLAGFPNPPEIEFCLTKEISNKKVRQTFINLLGESESTDQFVQSFIQKKNILYSKSPKNQELNQINKITQEIYQNQNQNQNQNQNKIQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQNQNQNLNQNQNQNQNQNQNQNQNQNQNQNQNQNQGKRKGKRKGGKRRGKQIDPSILFGSQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFH1</accession>
    <name>A0A9Q0LFH1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lysine-epsilon aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lysine 6-aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.36" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFH1"/>
    <dbReference type="OMA" id="FVPVSYP"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045484">
        <property type="term" value="F:L-lysine 6-transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017657">
        <property type="entry name" value="L-lysine_6-transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03251">
        <property type="entry name" value="LAT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF2">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE GABT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="430" mass="49140" checksum="C315D2352744A7BD" modified="2023-09-13" version="1">MAKRLTKEEVEQINPQTVHEVIGKFMLLQGFDYVFDFERSDGCYFFDSKTEKKFLDFFSFFASWAIGYNHPKMKEKQVLEDLARVAQVKVANCSFYTIEMAKFVATFARVCMPKEFVKVFYIDGGTLAVENAMKTAFDWKTKKNIEKGKNIEASKVIHFKKAFHGRSGYNCSTTNTTPWKTKYFPQFNWPRISTPVVKFPLEDAIKESSDEIAALVIEPIQGAGGDNHFRPEFMQELRKITLENEILMISDEVQTGIGLTGKMWGYQNYGIVPDIVAFGKKTQVCGIMATQKCLEVEDHVFLHFERIDSTWAGNIVDMVRATRILEIIEEDKLVENADKVGKYLLQKLLELQKKYPTLLSNTRGKGLFCAFDLPNSALRDKFSELCKSKSLILLGSGPTSIRFRPPLILEKKHVDEGAEIIENVLKELCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGF4</accession>
    <name>A0A9Q0LGF4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btb/poz domain-containing adapter for cul3-mediated rhoa degradation protein family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGF4"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF12">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="150" mass="17655" checksum="A1CA789F69E17E78" modified="2023-09-13" version="1">MKIRLNIGGKIFETTFSTLSLVPSTFFTIELSKIKKEEELEIFIDRDPKHFRKILNFLRNPNPNDFPLPSNLFILNEMKTEASFYQISTLVEIIENKIKFLSELSENKKKKTQDLFDKIHHVEVNLERILQAIDETYCGFQNGNFIIKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGL8</accession>
    <name>A0A9Q0LGL8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGL8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="760" mass="90939" checksum="8EA3C4DCF1ADB23A" modified="2023-09-13" version="1">MNSFQKEFNITKLLNEISNNFLSEVTKFKVVIYSLSKPFQIIIEFKQNYLFITKTLRMHYSDISMELSSLKDSTDFKLLNHIDNKFLKFTAESIEQRFIIQKLLQLNQTYNQNNFFISDISGKILNNQMEIDLLLQKMFNDRFGKLRFQIYTKNFKFINCNATLDKSRLYLDIEHYSIIAITLTTNFECYQNKNNSSIIHLVINTNKSKESIITFRCPNSNFGEFVNKILNLFIKNFAKNTIIDSNQEFISNDFFMNNIPDIPSFAIEKIVYSSKKTDDGNFSIFYTNYIEEEQEKQNQKQQKQQKDKTLFKEKSHYLEKEFSIIKNNDQQSKKKQIVDISVLSRKKIYGKLPDEPVLFEEENFLKMTKFCVSLVGKKSNQFMEDLDIYFSKFAITLIGLNYHSSVHLILKQFTLFEKKDDPKILQIVFNQGKKKLFQFKNEKDKIRFVQIYRICRENKVEKEKLTKLEKYFPLNIIFQEKEYIGTVILGEKRILIRIPNLTRIIQYESIKKQSDFKNRNHFFWKILSEEEEKEKEEFQFKFYSEFQKKLFTSLWNQKIQNLQPKVKKTYIQIEPQESLPLANEYPALIFDKQTYLMKECVIILQRNRFKIRMGNQQELIHFINQNWNIIIKKNNNLQIKIIFEENEFKLIFRSLETQEEFLRNFEDSKSKAHLFIQENQEKELDQENEIDLEEDQLIKFDKSLKKSKSSLQVTFQDRTDDSDITQTEVEPSGLVKTDIEKTDAISELELTEIDLSKFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGR8</accession>
    <name>A0A9Q0LGR8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGR8"/>
    <dbReference type="OrthoDB" id="10252328at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="399" mass="46050" checksum="C2F6468BCDD7D5B1" modified="2023-09-13" version="1">MSTIFDCIAQNKIYKLKKLLKQISNIDKPFKQTALHFACENNPNEDIIKLLISAGANVNAKTNYSPLHYACFKKAPIEVIRFLLVSGANINSKNKWNPLQIAIKSKADPKLIKLLLEAGSFVNNKDNQTPLHDACENNYEKSIIKILIAAGADVFAINKCTPIDLAKNKEVRKTLREFQPIIREMRKFCKKRELTDFTINCKDGKISVHYLLLKIRIGKEKIGKMNGIFAQKTKEEVEEILEFIYSGYVPENQEKIEEFCEKMEINFEEKKGSKGILKDLKELYLDEETKDFSIVEPKTGNKIKVHKLILMARTKLFYNMFSVVKDESGQVNDYCGRSTQSISAFVRYLYSDDFPQDVSYDTFYHLKDAFDYFELYKYSSFNYRLAHSVVDSSNLISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHT0</accession>
    <name>A0A9Q0LHT0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Er lumen protein-retaining receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09097</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHT0"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5073142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="215" mass="25173" checksum="5ABB1DD8E38C68F1" modified="2023-09-13" version="1">MYNIFRLAADFLHLSSILILLMKIISQKSCAGVSLKSHEIYALVFITRYLDLLTLSGGFYNIIFKIFFISSSVIIVYLIRYKYNRSYSKRLDTFRVVFLIAPSAVLALIFTDEYSLLEILWTFSIFLEAVASLPQLFLLQRSEGEIETLTSNYVITLGGYRALYLLNWIWRLITENHYRAWVVWMCGIIQTAIYSDFAYYYFKAKFEGKRLSLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI94</accession>
    <name>A0A9Q0LI94_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI94"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="425"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="534" mass="62357" checksum="3D6E28E4D850A9A6" modified="2023-09-13" version="1">MRSELYRGMFLSVTKDKSNKVTDYSELITIGFENEAILTKEGNVFAKGSYINPQNPNEFINISSLIEDTNDRIIEDIVSGRSSIYLLTSNQNVYGIGSNEEGQLGFDSETLKITEKPILMMKNVSKIFSGNSSIHVFLLNSNQELFGCGWNEYGQVGLGESRKEEESKIQNIPKGKIIDIKCGFSYSIMLIENENENENPKRKLYSCGDYRYNGLGQNEKTYEFTEIKSSLFENDDNILEISVGFKHTLILTSNSKLIGFGENLYGQLGTGDTYWNQLIPIQIELPELRFNEDISNYHISCGYFSSFLYYYFPLFSNLEEDLIKLFERKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNKIEKLKEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKKIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVRDYSELSNKSFQILEYWIYSNQIKDEIQITQEMIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIZ4</accession>
    <name>A0A9Q0LIZ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIZ4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="310"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="583" mass="67856" checksum="01EFB59BFA2D0C8D" modified="2023-09-13" version="1">MNDCLFFGLNDYPKLIKNETDKITKSIQFKFENENENENEKQIKQISTGFFSTIFLFKNGKAIEYSRYSKQNPSKIQIKNIQKVAVGYQNEAILTIEGNVFAKGYNINPKNSKEFINISSLIEDINDRIIQDIVSGIGSIYLLTSNQNAYGIGSNEYGQLGCDSETLKKTEKPILMMKNVSKIFSGNTSNHVFILNSNQELFVSGNNNYGQLGLGESRRKETKIQELTKIQNIPKGKIIDIQSGFYHSIISKSKIQKENFYSCGDYQWNGLGKNRDTNEFSEIKSSLFENDNIIDFSVGNFHTLILTSKSKLIVFGYNEYGQLGTGDRDNQSIPIQIEIPKLRFNENISNYHISCGYFNSFLYYSSPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQNQKLQEIISKKSIKESNQIFEMIYSNKIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIKIGIDYFQLNQTNPNLIDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ27</accession>
    <name>A0A9Q0LJ27_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ27"/>
    <dbReference type="OMA" id="YHDVNTH"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="324" mass="38105" checksum="C6A11E3879219A26" modified="2023-09-13" version="1">MMYVSRVYPDVNTQQPKDYWDYENYSIKWGKTSNFEINDYVGRGKYSDVFEGFDKTTGNKCIIKALKPVRKNKMKREVKVLENLRGGPNIVELIDIVRDEHCSTRALILEHLENEDYKELYDNFTDHQAKKYLFEVLKAIEYAHSHGIMHRDIKPHNIMYNPSKDVLRIIDWGLAEFYHPGKEYNVRVASRYFKAPELLAGFTRYDYSVDMWAFGCLLGSIIFRTIPLFKGSDNNDQLEQINKILGTEEFFEYLEKFKIKLPQQYSSKLKAFPKKEWSSFISDSNSHLCSSDAVDLLSRLLVYDHSKRLSANEAMKHSYFNDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ73</accession>
    <name>A0A9Q0LJ73_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="126"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="287"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="453"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="618"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="783"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="948"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1111"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1457"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1630"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1796"/>
            <end position="1914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1945" mass="224412" checksum="3A291182EC3BCA08" modified="2023-09-13" version="1">MLRKTHYFLIGKKNMVKDCELDDFDFKNLLKLTKFGIGIRVVLNQIKTLIYMDRVGKNDLIGRSKVKTRKDQLIYILKYQVPILKKIDPKTGNEPQHGKITGKIRIEFAQDFDFGLIQQFVGIIPKVYKYELSPKEDKIAVAFTISKGHGIPSADIGGLTDSYCQLRLGLNEHKTEVKKNTLFPDWKETFKNSSLTLKELKEIKMTIWDWDRVGKNDLIGIAKVKVNELLKTVLKPNQLIYIVKYRVPIQMKVDPRKGPQPTHGQITGKIRIEIPQGFNYDILSQWSGLTPRIFQHTLPIKENTIAIKFKIKKGFGLPQSDLSGLTDGYCKFRLGQEDNETRIDKGTLYPSWKNTFTSNLTLKELKKIRIQVWDWDKVTAHDFLGIAKVKVNELLKTVLKPNQLIYIVKYRVPIQMKVDPRKGPQPKHGEITGKIRIEIPQGFNYDILSKWSGLTPRQFQHTLPIKENTIAIKFKIKKGFGLPQSDLSGLTDGYCKFRLGQEDNETRIDKGTLYPSWKNTYTSNLTLKELKKIRIQVWDWDKVSAHDFLGIAKVKVNELLKTVLKPNQLIYIVKYRVPIQMKVDPRKGPQPKHGEITGKIRIEIPQGFNYDILSQWSGLTPRQFQHTLPIKENTIAIKFKIKKGFGLPQSDLNGLTDGYCKFRLGQEDNETRIDKGTLYPSWKNTYTSNLTLKELKKIRIQVWDWDKVSAHDFLGIAKVKVNELLKTVLKPNQLIYIVKYRVPIQMKVDPRKGPQPKHGQITGKIRIEIPQGFNYDILSQWSGLTPRQFQHTLPIKENTVAIKFKIKKGFGLPPADKNGLTDGYCEFRLGKEDQQTRVDKSTLYPSWKNTYTSNLTLKELKKIRIQVWDKDKVTTNDFLGIAKVKVNELLKTVLKPNQLIYIVKYRVPIQMKVDPRKGPQPKHGEITGKIRIEIPQGFNYDILSQWSGLTPRQFQHTLPIKENTIAIKFKIKKGFGLPPADKNGLTDGYCEFRLGKEDQQTRVDKSTLYPSWKNTYTSNLTLKELKKIRIQVWDKDKVTTNDFLGIAKVNVNELLKTVLKPNQLIYIVKYRVPIRMKTDPRTGKQITHGEITGKIRIEIPPGFNYDILSQWSGLIPRKFQYTLPIKENTVATKLKIKKGFGLPPADKDGLTDGFCKFKFGQEDQQTRVDKSTLYPNWKNTYTSNLTLNELKKIRIQVWDKDKVSANDFLGMAKVKVRDNLRETLRKYYQTPNQTQPPIFIIHIPNVPIILPINPRTGPRGSHGRISVKLRIEFPINMNPNLISQWSGLTTPIKTPKILGPDASKPVWGVSIKIRKANNVRASDSNNLSDPYCKFVLGTKEFQTTTTHNTLYPVWKEKFREVIDPTTFQKIRVSVMDYDKSSKDDLLGFATFDLKPIVGNKYNQNECVFVERITKPIRYSSKPGKVYPANLGTLEVTIRIEIPIKVYTQQMVNKIVNPFPENEYVILQDPNSNQVGFEVVINKTRDLICQKPDKFANPYCQFQLNNQKLTTNVVKHNNHAKWKSHFRSIGNIDIFRRFTVDVLHQSKKLLSNKVSKTYYLGHFNISVFKLIKESVKQGKMINIIKGMWFNVKSPRDGKTGKVANIGKIHIKLRVELPQTIQMNYVRALCGIEGYAPPAILFNPQNLAQNQWGLRLFIKSGFSLLSLDSNHLSDPYVTTRIGTQDFRTQTIMKTLYPEWRENFDIISDLKDLKKIRLNVIDYDKVSKDDKIGVVTLRLWNLLGKHLKPNQTTYEFKVKEPIIVKSDERFEVNKKHGLLKMIIHIQLPFTAQWDFMSRLCGLSPQIYEPIMKVGIGQWGVKFDIIRGIGIPPADKNGLSDGYIVLKCVTSSFKTKVVSKTLNPIWKDSFEIIDSPQELKKAYLELFDADKMTTDDRIGHITLHLHELFQQHPPPQGYSVSVFKDWYDLYDQQDKKHGKIQIRIRIEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK00</accession>
    <name>A0A9Q0LK00_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK00"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="388" mass="44585" checksum="11A96AA28ABB7BEC" modified="2023-09-13" version="1">MNFKQFSNINFEEIDENEPIVIDNGSFFIKAGFGGDDAPRAVFPTVVGRQRYQLLMVGMGSKDGYVGDEAVYKKGILIKKYPIENGIITNWEDIEHVWHHTFYNELRVLPEEHSLLMTEPLLNPKVNREKTTQIIFETFNIPNFYLSNSPSLALLTSGRTTGIVIEMGYQFCNSVSIYEGNALNDSVLKMNIGGKDLTDYLMKILNERGYSFTTTYVEREIIRDVKEKLCYVSLNFDKEMELLNNSNSIEKNYELPYGNIITIGNERYRCTEPLFKPSLIGFSQIGIHEIIYNSIMKCDEELRKEMFGNIVLSGGTSMFQGIKERIEKEIKQLSPKNMKIKVIAPPERKYSVWIGGSILSSLSFFNRITISKEEYKEFGNSIIHKKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKC0</accession>
    <name>A0A9Q0LKC0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrator complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKC0"/>
    <dbReference type="OrthoDB" id="10067569at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045334">
        <property type="entry name" value="INTS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019333">
        <property type="entry name" value="INTS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587:SF7">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10189">
        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="292"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1027" mass="121348" checksum="22D23C8F0618F352" modified="2023-09-13" version="1">MQESQQQQNKITLFVKQPLDADDEYEKKSKEDFELIQKELRNKTETERASIFQSKVFGGTESEKQVVNVLLYGILTSQSAFKENFTLLTSLTRDQFSICISSIQFIIFEKYYKLHPHCKMQLLLLVKELVMIEAKDSELLVLELLRQIIGSDLSDTNLWLIQSLLEILTECPKTWLFNYEMLIYISCYTFLRLISDHIGVKELSQIQNKEINYTLMLLKEKTDVCFSIGRDLIRLLQNLNSIPEFKPIWDLLLLTKEEYYNLDSKKKEEIFLKYIKEPNNENLLPNKSVPIPKELSSGQTMLEKILNTRTKKICFQSRLTPKIETQLLFMVQKIKMGMQRRHQQWFFTQHLSSDPLPNKQIKLKEGLIIDLIRYVCCAYHPLPETVYAGFLTRWATIGWLLKSIHSSKIQHQAKIALFYDWLFFDPSQEIIMDIEPALLLMIFSIPKYFDITSQLMDFLCDFGIFYEPNESIKIHTKQSIIEAFKQSLDKRVISFIQFEQLFSSEVLHDSLKSKFKNIFGSVLNSSQDEKQNQQKINPMELENDNSKSRKRGLKEIISNSKTKEKKHNMEKNHQENLTETISTFREKFSKIIDNFPSLNEKTKSKEIHHLITDFFRVSKKKFLSSEANQANQELVFQFIFNTIASCKLLSYQKITHLFLSLIFSYEKDNGTLKNLIQNFRRIDKKFGARILLFILSEKSMLPKISFYFGENSSEQSYSLLFYDFKFAGQQDPDLLFQVFVACLTSKQTQITNKIIGQFEMIFLIVQFLDPKLQFEIQKLLLLTKIKIFGTKQKNLIQIFEKSIELLNSYEQNILWNFFQAEFSNQISKIENVCLILLDYISLKTEKKIEELKKKMEKSNEILRKFMDIDSLENNENQNEDEKEKEKEKDKDKDNEKEKENENENENEKYSLLELNNSLQIESSSFEFYHEILNQIRILLSRISPSQKLIITLMSFPISSNEDAINSFTNSVLYQWNIHQEHSKQLKNFIENILKPNSHEFGNLKKTVKDRTKIWKENFFKEEQNQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL38</accession>
    <name>A0A9Q0LL38_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL38"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="143" mass="17396" checksum="ABB1FFF78D35B464" modified="2023-09-13" version="1">MIYSNRIINPILYSEIKEIINLNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITKEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL91</accession>
    <name>A0A9Q0LL91_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein 4a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL91"/>
    <dbReference type="OMA" id="QTRGIWH"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="132" mass="15460" checksum="41A934605D64A04C" modified="2023-09-13" version="1">MSIKITINTLTGEEIKVEMNENQKIKEIKQLISKEKEIPINEQKLMFDDVKLENNKTIKEYGIKNDSILNIFIVDPQSSEPETPIENETKNETKEKKDETNNKSNPQNQSKNNKNKNKNKKNKPKKKRCIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLL7</accession>
    <name>A0A9Q0LLL7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_07784</name>
        <name evidence="12" type="ORF">M0811_07802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLL7"/>
    <dbReference type="OMA" id="IHHVSEF"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000003">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5075079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5075097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="208" mass="24069" checksum="9E6F1051BF7645A6" modified="2023-09-13" version="1">MNSDKAWQQFQQSKSKSEKKKKQNVHQSSVLHPWHGIEPGEDPPNECNAVIEIPKGSKVKYELDKETGLLRADRVLYSSVVYPTNYGFIPQTLGEDHDPIDVLVLMQSEVYPLTILRIRPIGLVPMIDCDENDDKIIAVHLDDPEYKDYHDVKELPQHRLVEIRKFFKDYKVLENKTVKVDEPKGPEEAKEVITKAIQEYQKVFSNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLS5</accession>
    <name>A0A9Q0LLS5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-binding protein ipp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLS5"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="554" mass="66465" checksum="A8E77481A0A15EE5" modified="2023-09-13" version="1">MEQQQILNKKEKRFRNNLEKLFIEFENWRNKIESAEIENQIQIQKTQIHKPFLILQCPQLIPEIIEAENKKNKFTLDFTKIVENENEKETKYEPIKPEVVEQILDFIYTGEINISEQNVLDVHKASILLKNEQLDFWCEDFIKESFTDGNVIEYLQIPWIQKNPLLFSTGVTYLKHNLSDIIHSKDRKWKSLPKKIVDEIFDSENINITSELDLFEFAINWIIYQIDGENGRYFRNIWRDRPRELKEEGVKKFRENFLKKIRFPLMPKEEIESVDTFKILSKEVIQKLKDYIDISSKIPWLEGNYKEEKEKKRNVLINDLKTNVDFKLPEKAFEVRKFDPKIKDLPKQENKEMKYDFGDLKKIFNNESFGNYQQIFSTKKDQFSIQNFRRNCEENKGKWFMIFTTTTNDIILAFSTITDYFKPEKENYYIPDDSSFIAVLQVNGEKLTEDQLMKYGILYLKKKDQKNNCALIYSVNYGPVFGDHDLSISDTLLNCYCSWGFKYLPKEINKPLFGNSKFWENWRVSKDEFLKKMGLFFSKTRHRIIDFQIFTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLY3</accession>
    <name>A0A9Q0LLY3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_08682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10025033at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="606"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="819"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5073565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1470" mass="172487" checksum="6BC5F3AFB5045C53" modified="2023-09-13" version="1">MRRKKRISKQKKLKNNNQNQQDLSILSPELSAQLGITNDYQTNDLSNQIIINKKNEKEIEKQNQKKLQKKIEKNQPLKKKRISKRKEKKLWKLKMKQNKFILKDKLINQVAKGNLNDDKLKLFRSSKNLGKKETLKEKLKRDENQNKNQKLKENQIENQNQNENENENEIENQNQNQNQNQNQNQNQNQNQNQNQNQNQIENENENENENQNQNQNKINYENQNKNQNKLKENQIENEKKIEIEIQNNKENKAFFVLVNRKKEIQKHRLELPIISEEYNIIDYIRNGNLLIICGETGSGKSLPNSSIVYTPYGPQKNGNLKKGDLVSTPFNQNFSKIIQIYPQGKLPVYRIFFDNNDFVDCSLDHLWLVDEYKLNNSNPQKKLYKTKQLLKYINQNSSKFKFSIQNPDPIFFFPQKIDIDPYLFGLSISFNDISSSNNYYLFIYLLAKRFNDINQFQNYQSFYKHLLHNKKSIPKKFIFNSISIREEIIHSFLDLNSKITKSNNLIYQTKFQKIAQNIQLIIQSLGGLCTINNLKNGEFQCEIIYSNPFKYRNLNKFNLINQQKNVHLKRFITKIEKNREEECSCILIQDSDHLYLTNNFIITHNTTQVPQFLYESGYGSIKSSNPGKIGITEPRRVAAVSMAKRVSEELNFKLGEEVGYQIRYDKKINDKTVIKFMTDGILLKEIESDFLLQKYSVIILDEAHERTLNTDILIGLLSRIVMIRANLYLESRKKKLNLEKEIDDDLMDVNKKIDIGNKPTLLKLIIMSATLRVEDFTSNSNLFPIPPPVVNVESRRFPVTIHFNKKTPLNDYINEAFDKVVKIHKFLPFGGILVFLTGKREIIGLCKMLKKKFPMRKLDQDHELKMEIEFKNYFFDDEEEFNNYNENENENENDYESEYENQLKNLDQNQDLIIPDLKSQPLYVLPLYSALPTKEQMKIFEEKPENTRLVVVATNIAETSLTIPGIKYIVDSGKVKEKTFDPNTNISKYSIVWISKASAEQRAGRAGRIGPGHCYRLYSSSVFQNFFPNFSQPEIKRLPIEDIVLQMKNMGINNIIHFPFPTSPEEKSLKNAIRILLNLEAIEKSTYKITKLGRILSQFPVLPRFAKMIVLAKQYNCLLYIIAIVAALKKLSQWKNSKSDILGILKAIGAWLYSGCSEKFCIENYLRYKSMVEIYKLMQQLYSICLEIFSLENENENENLLSKKYVKLYNPITSIWEKQNTNFQNLKPPTKTQENQICQIITAGFCDQIAKKIGKKQSKNQNFVLTEYLSCESEKILYLHPSSSLFEEQPEYVVYHEIIESSKPFMKGITKIESNWLSKLSPNLCEFSKPLEQPSPKYSSEKDQITCFVIPSFGIHSWKLPLLEIEIPSLSERVKYFALFFLEGKIFPQLNQIKQYLIESPSIIVKSSSFPQKKIYNLLHILLENQIWSKNSLIKKWENNSQFLFEEISLWFRKNNQKKLYNIWKIITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM11</accession>
    <name>A0A9Q0LM11_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Import receptor subunit tom40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_07912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM11"/>
    <dbReference type="OMA" id="MNLPCPV"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5074869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="377" mass="43147" checksum="421E837B42A45D7D" modified="2023-09-13" version="1">MGNQVKKTKESRSQETKVEIPLENTFKLTNPGKFEQFCKESTQILNVETFDGFRLEVNQQMNQSFGLTHALSMGSLREEPSYTFGANYVQEKYALIGNRKNDGTYARYIQQFGRKFLTTLYTQISGKKQEDSQDTFGADLEYYGENFTIQSKLKSNKVFGLSYLQAMTPRLNLGMEFIYYHNMKTSSIIFASRYFTHNFIFTSSFSTFPVKHFSLHYVQKITPRVGLAAEFIYNIENGLSAMSAGYLYSLRQIKVGGQITSNGKISTLVEQMLHPLISFKLSAEIDYISNTYLFGYGLRSNEKEYYAAVLVTSKYDGEESKTLGRPKLNIVIVLDISGSMGSSFIQSDERRSKNDQETNLNVRLTNWKLQNALFEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMA3</accession>
    <name>A0A9Q0LMA3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMA3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="147"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="265"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="488"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="782"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1167" mass="136165" checksum="0E9BA1103291236F" modified="2023-09-13" version="1">MNDCLFFGKNILPKLIKNEPEKITKPIQFENENENENENENEIKQISSSYFSTIFLFKNGKAIEYLNYSKQNPEKIQIKNIQKVTVGYQNEAILTKEGNVFAKGEDINPNNPKEFINISSLIEDTNDRIIQNIVSGSRSFYLLTSNQNVYGIGSNQNGQLGFDSEILKITKKPILIMKNVSKIFSGNSSDFIFLLNSNQELFGCGDNFYGQLGLGKSRKKEIKIQKLTKIQNIPKGKIIDIQCGFAHAIMLIENENENQNQNPKRKLYSCGDYSNNGLGKYGNTYEFTEIKSSLFENDNILDFSVGNEHTLILTSKGKLIVFGSNLFGELGTGDTINQKIPIQIELPKLRFNEYIYNYHISCGFHKSFLYYSPSSNLEEDLIKLFERKEFCNISFKTENEEIIEAHKLILKYRLKDQNQNENQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNESFQIFEYWIYSNQIKNEIEITQEIINEIKRGIDYFQLNQTYPNLFDLLINKFNNQNQNQIKKKEKKEKYKITKPIQFKFENENENEKQIKQISSGSFSTIFLFKNGKAIEYLNYSKQNPSKIQIKNIQKVTVGCQNEAILTKEGNVFAKGEDINPKNPNKFINISSLIEDTNDRIIQDIVSGYNSIYLLTSNQNAYGIGSNEDGQLSFDSEILKITKKPILMMKNVSKIFSGNSSDFIFLLNSNQELFGCGDNFYGQLGLGKSRKKEIKIQKLTKIQNIPKGKIIDIQCGFAHAIMLIENENENQNQNPKRKLYSCGDYSNNGLGKYGNTYEFTEIKSSLFENDNILDFSVGNEHTLILTMKGKLIVFGSNLFGELGTGDTINQKIPIQIELPKLRFNENIYNYHISYLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNEIEKLQEIISKKSIKESNQIFEMIYSNRIINPILYSEIKEIINLNEKIEETMKKIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELNNKSFEIFEYWIYSNQIKNEIEITQEIINEIKTGIDYFQLNQTYPNLFDLLIIKFNNQNQNQIKKKEKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMP0</accession>
    <name>A0A9Q0LMP0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMP0"/>
    <dbReference type="OMA" id="HACTAGS"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="124" mass="13250" checksum="200575461D02EACC" modified="2023-09-13" version="1">MNPNDEDFSPVEALLDSASHGDLQGIQKLIDAGVDVNSQNEEETALLLASINGHSSVVSSLIKLGANINHQNQFVKTALILAVTNGHIDVVKELMKAKADKKIADQGNTAMDYAKNKAIQDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMQ1</accession>
    <name>A0A9Q0LMQ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein sip5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMQ1"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="174" mass="20394" checksum="339D1C1FA2281ED1" modified="2023-09-13" version="1">MGNSKSKVAPHKEFYKPTGMYPKIEWDQKTIRTRIKKKQLAPIYPLQTNKMDSYIEECPICFYRFPSINRTKCCDKPICTECFLQITPKYPTNENKCPFCQAKEEETQKKEQENVKNLNENPNENPNENESRVTVPGPFDEMLRLAIQQSLDDTSLTFDQDFQTALALSYQENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNB2</accession>
    <name>A0A9Q0LNB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNB2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="175" mass="21030" checksum="5B7CB430283005B9" modified="2023-09-13" version="1">MNLKNQLKTHYNQLEITQSVNFEKISTQVILNLFQEVNDLLSNKKNFFQLKKKKIKEKNFANVVNRLNNISEMLNTIKDKFNLINQEIDIDQKILFTLEEYCIHSKKRNLEKEVHEKQNQNQNQKSNQNQNQIENQNENQNENQNQNQNQNENENENQNQNQNEIENENQNQNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNG9</accession>
    <name>A0A9Q0LNG9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_00974</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNG9"/>
    <dbReference type="OMA" id="LQIYYHY"/>
    <dbReference type="OrthoDB" id="419508at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040532407" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="10">
        <location>
            <begin position="536"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5074345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="650" mass="76037" checksum="4C6C88CB75CD6F4B" modified="2023-09-13" version="1">MKINLFFFFLLFFIFVFSTRNFASVYWEYNDYQIEFGIADPTAICYGIFSDTLFEIGTSKLHIYTNSTYNDSIQMYAAGFVEGALTQQAIWDFFTNWKILFLQDFNTTIWPEKIMTFMNDNQDYLIEQCGYQNQTEYIKQICLNYQQFLGLIKGYQYEASPDKMMNYLDFWMLNSDGDLSSLSVALYSLSDDPKEQEWAKNKINNIVWKETNSHCTALVKVLDGNTDILFGHDTWEFFSSLSRIWKEYNFQLSSVKAETIMFSSYPGFISSVDDFYLTSQSLGVLETTIHAWNLTLFQEYLIPQTFLTWIRVQAVNRLSASGQEWTNLMDSINSGTYNCQWLILDYKLFNKGSALQDNLLWVTELIPGYTWADDQTFWLRNRTWYPSFNRPSNPFIFNISGYEHRVETEGIDWSYWNCTRMLIMERDVNEKVYSYETFKEMMRYNHYQDDPLSHGDPGNTIAPRYDLRVENSSCLDCKSLSYLEALNLQFSAVSSPVHKYVPVFTFEGKWNNFPRQGLPITWEFPWHNFESVKTTTCGDYETCEECIQSSSCGWCEERCLKYPVLVGETNLCLSDNWQINQCSSVNPSQSNSKSISTGAWIGIVFGVSIFCGVLVGIIVFFFPKKKSKKETYDKIPNQQLKERKDEEDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNI8</accession>
    <name>A0A9Q0LNI8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-related sulfurtransferases-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNI8"/>
    <dbReference type="OrthoDB" id="2012972at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050229">
        <property type="entry name" value="GlpE_sulfurtransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43031">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43031:SF1">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040306860" evidence="1">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="66"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="173" mass="19416" checksum="B200F9144B6376AA" modified="2023-09-13" version="1">MKQILILISFLIVFSYGMVQEQAYPKKPIPSTKVIPPYDFAIIQKYAEEFLAKPYHGLMADTVYPDLEDYFIVDIRSPADYCSGHIANAINIPFHTIAANSSLAKLPTDKTILVYCYTGHTASQSTAILNLLGYDAYTLQFSAMAWRNVTQVGIWSDSHLEDVYGANYPFVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNR1</accession>
    <name>A0A9Q0LNR1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beach domain-containing protein c2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="MEDNFMQ"/>
    <dbReference type="OrthoDB" id="409642at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="94"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="2936"/>
            <end position="3042"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="3062"/>
            <end position="3170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1949"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2104"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2157"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3136"/>
            <end position="3158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="507"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="759"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1712"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1854"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2644"/>
            <end position="2671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2865"/>
            <end position="2947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1951"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2104"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2117"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3146"/>
            <end position="3158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3170" mass="384956" checksum="7838827642398469" modified="2023-09-13" version="1">MNQNQNQNQNQNQNQNQNQIQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENQNENEEIQSEIKKFNKFLINQANKQIGLMFGNKKTSDFQIYCGKDKISIPCHKSILEARSKYFMINRRENKLNTIYFHNFSSEIVKPIIKFFYNGKFKFDKQKFDEYFKFANEIKLKEIQFKIELEIQSIFNIENILEIYFKIQKINSKNLSQNCEKFIFQNIQFIISNPNFDKYLNQNQNQIYNFIGLISLNQNLPNQLQIIQQIKQKLNENNQKKLIKLINFEINQKKNENENSFSNLLNQISQTKSINQFQIQQIKNKSISQLQNKIVLLNSNIEEFEQEKQKTKFKINRLKEKKSIIQKTNFEKQEEKEKLEKIKNEIQEIQKEYQKWEKEIEEKFQQLIQNDEKMKEYLQEYNKIINDLKKLFEQNRKKDLKNFQKKIQEIQNKFKKRKNINLKEIDKQYQELINFPKLKTQEDLKLFEETIQQFKKGFEKKRKEKFEEFNQFIQQKKNQNQIENENLDKIIQEIKNRIKSKKNNYLEKIEKKIQEIEIKNETLNEIEKIIQKFKNQFEKRKNEFYSKIDPQIKNIQNEIEKVQKYTSNKAKEEITTDLNTKTEDENEKEIEKQKEIEKQKQIEKEIEIEKQKEELEKDFFLSFGNQNENGNEIYQKWKDLQPKNNSEIKSEEFVEFCLLFEKLFQNWNPNQNESNLNQKKNEFEKYFELKEIYEAISQKQAHPIRFINFILNNLIYSNTLLQETIQNETQNQNNQNQNQNQIQNQNQNQNQNQNENQNQNQNQNQIQIQNQNQNENQNQIQNQNQNQNQNQIQNQNQNQNQNEIQNEIQIQIQNQIQNQNQIQIQNQNQNQNQKEINPHKNLISLSIISILSKSKFNQQILFEKRIFKIFYDLLQTTKYIFGLMKHIRETKPKLSIYYLIETQFIISEIMEIMKKFLKGKDFYPNKEILKSIKESKIILSLIEWFLINLEFKKEFLFTKKQYSIQLSIFEIIESCYEYGLLTETEKIDLILILLTFFQVPKLSNIPNIGINIINKNQIKIENQKENEKIKKIEIEKLEDIFETNFFTFKSEIKEEENPNILENLKIKKEDSIRLEVDFRLNIFDFLSFIIEEENIIEEFINNNNILNLKDFILWISYTFKTKLSNKLKKLIHFNSKHHSKSKSKSKSKSNSNSKSKSKSKSISKSKSNSKSNSNSKSKSNSNSKRKISEIKLYHPYFYSLFNHLISFQKIQKSNNTNLSKENIRKEIEKYTNEIKIKVNNFKERLILIYFDLFKSEEELNSNLQYKYKNYYLKKEKIKKIQKYNKDIYPELQMYILFELKKMIIVENKNDDKEIIKFFEENEGWKICFSDYFIRTNINNFNIEEKEKIELEEMNLNLQILLIDFLKNIIIKYQNNFEYQILFIQISKNSKIISNSFLLNQFLEMIIEIIQNNPKISSNKIFENNGFQIIKQNLLKLIKENEIQIQNENENENENEKTKELYFEILNLIFQNGSIKVIFNNSNIINFLIESINYQFLQKLSLNNIPKFFEKVTNNEEENEQQFIIYLIQKIFSKNQNQNENENENEKFQNKLFEECLKSISKNRNNIQKIFLKTNLLQIITTFFEDQNNNNNTYFSLKMIKEIIENNEILMKQFQELIPITKFVKIIYEYEKRKPKKEIFEILLDLMINNGKFSIKNNFIIKNTNMINIILELYSQNFKKELENQIENEIENQNENQIQIQIENQNEIEIENGNEIEIEIEIENENEKENENQNQNQNQNRIENEKEISFFEVLKIFEEISEKSKENINYICEKGIISFLLKLIPKIQNIKIFKKIIEIIGKFANFKITVSEMKQYFTIMKNQLNQKIKNQLNQNQEFSSIIMMNELRKINKKQQQQEEEISKNIIKEKTNKIKTIKTFKSTNINEIIKFLGGIETFFYLIFEIDELFKQQKKEIKSKSNSKSNSNSNSNSNSNSTSKSKSKSNSNSTKLIFEEILRIINDYLLNDIETQKEMIEKQGFQIINILLKKIHPKYFSTQIYYIIRTFKENIENEQFQKQLKKYLIFDYKIWKNYNFKIQNKLIETIQICIQNQNQIQIQKEYQNENQNEIENQNENQNQNQNQNQKKKEKENEKEKKSNPSNITIFDLLKLIYFYDKSLYKIQNENENENENENENENENENENENENENENENENENENENENENENQNENENQNENEIENQNKNQNENEIENQNEFENENELKREEIIKIIEKIFSIIKFMLNNIESKTQRIFIHYLIKRCFIFKTKYFIEKTLELIHNYILNNLEITWKQLFSNHLFYPFIQIMKENKGNIKIIEISLEIIYFIDISIHKNEKENEKEKEKKIFQKFKKNQKQIDKLKDIYYLINQIIIENINNISKKIINILFKIMIYDYSNKTIKTTRLIENGFILETICEIFKQKSKLINIKELNQLFKIILENNLNKEKIISEIGWQKWIISLINFNYFNFHSKIKIKIKIKIKFKIKIKIKTKMKMKIKIKIKIKIKNQIQNQNQDQNQNQNENLNEFAFKILNILFEYCFQNPKYDFPKIIEEFISTIKIIKDERKETITKIILKIINNLIIEIIQNTEKKKYDFQEEISQSSIEEIFKKTYQMNQFYKNLFYLIYLLNEILFNSSKEKSNNKKNQEIEKEKENKKEFKIKILFENEFIENFIKLIEKFGFFGKIPTQFSTKKEKIRIYKNIILILLFSIPKSNYQTTEFILLKLKEIMKEKFNQNNFSKQDSNEFLKICFSFLFHYIHNHNYFQFQNQSQIESQNQKEKENKAKRRFLIIYLQTIIQDNYRFLYEIISKQNQKQLLQINPKESFIFKTDIQKFEEEIMKKEWKQITNQFFFPIIKKIKKEIEENQKEFIENEKNKLNNFQNQINEKQKENEINLQKIEKEIENIRKQEKERKRFQKQKQKQEIRNHLQKLEKMITNSLIGKYPWNSRIFEITTNSINFFAESVYSNQNENENENENEKDYSWKIEMIKIIHKRKYISKQTAIEIFFENDRKYIFFNFSTTEERDEIYEKIQKHKSIQIESINQTKYNYLINQTKKWNQKTPITKEWQERKISNFEYLMYLNTISGRTYQDLSQYPIFPWIISDYESKKLNINDPKIFRDLSKPITKLNQNQNQKSKSKSKSKSKSKIKIKMKIKPRNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPN8</accession>
    <name>A0A9Q0LPN8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06456</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPN8"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5076456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="346" mass="38952" checksum="DCD1123C8EF38EAE" modified="2023-09-13" version="1">MDSDDIAALVIDNGSGMIKAGFAGYDAPIAVFSSIVGRVRHLGFMFGMGQKDSYVGDEAQSKRGILTLKYPIRNGIVTNWDDMEKIWNHTFYNELRIAPEEHPVLLTEAPLNPKSNKEKMTEIMFETFNTPAMYVAISPTLSLYASGRTIGTVVEIGDGVTSVVGFNESFRIFSSIQRMYLAGRDLTEYLMKIMTERGYSFVKTYEREIVRDIKEKLCYVALDFDQEMDIAAESNSIEKNYELSNGEIITIGNERFRCSELLFQPSFIGMEKSGIHELTYNSIMKCNVDIRKDLYENIVLSGGSTMFPGISDRLQKEITQLAPPNMEVKIIAPPERKYSTWIGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ40</accession>
    <name>A0A9Q0LQ40_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arf3-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ40"/>
    <dbReference type="OMA" id="EYTQHIV"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="14"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="694" mass="80617" checksum="C5EFCD26B7EE4E7C" modified="2023-09-13" version="1">MNKENKTKKPKNIEYVLYAEFDALTGPTIRFQYPKECGTNESNLEEWMIPDGMHDRNDDSTTFFLNREGEVTIFENIDDDENSDQFNKDKNNENNNQNKNDHISEVESDEGWKILGDSANCIIFQDEKIKIYSAEKCGDFSNPAQDSFVYDISFHEELNPTPLGELFSCIYDKNLNTIGFKFFDGKEDDEKLFKELLTKFIETQGIMKTQQEIENERLEQLKQEKKLEEEKKLKQEHEKKRKPFLYCTNVCKSKKDPTARRGTRINSMAICSRLQFSPVFKSALVLAVEKTLDFPDDARKIAIELFNAVNAVDLTECPLWTEQQKLLKRILNVSHNEFVTNLEFQSEKIPIHIPLTLLEDEVGEVSLINVLKKFQHNSMHILNGLLTNKKIIFIGHKMKAGDVCGYVLASILMVCPPLRGLIRRIYPYADLKTIDEFIDIPGYVIGVTNQLFASKQAWWDILCDINTGTITINPNLVEEFENSEHQAYDKQFIEKCLTSLENSSEQYIRGSFQEYTTHIVKMALEEEEFNDATSRLSEMKANFKRIQQWRETEMHKTYLSDQEIRKELLIIKSIDVQRLIRRLIIRRDLDGNELFNIYESFIKNITTEEECMEFLSYFPEAKGGLYPLAVNLFHSSEVVRLGTVALLKRLDGIKTGSGLITGLNMFLLLAYERNVRQLTTKLEKFMETIQTKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQI0</accession>
    <name>A0A9Q0LQI0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQI0"/>
    <dbReference type="OMA" id="HYECENG"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="387" mass="43198" checksum="478A39BC2E5A8300" modified="2023-09-13" version="1">MSEKKGKESKDFWKAIEENNSSFLKKNKKQLILQKNKDNQTLLHYACIKRAKLSIIKLLVQNLNINTKDNLGKTALHYACEKIPTKTVLTMLIKNGANIHAQDGEDHLPLHIICTRKRITEKELNLVIQPETDVNAKDNENKTPLHYACEYKLSGEVVMELVQRGAKTNQADVQGKVPLHYCCENGGRLEVIDVLTKTTISINEKDKEGRSPLHYACIHKLKVECVRLMVERGAVVNAKDTSKKTPLHYECENGIRKEVVELFLSNGGVANPKDENGLTPLLILFAKTGQSEIVKILIENGADLALQDQDQLNSLHHACKNAVETVVLEMIVAKGVDINSRDSQGKTPLHYACENTPRADSLALLLQKGADPNAQDAPLHNSSGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQR8</accession>
    <name>A0A9Q0LQR8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hect e3 ubiquitin ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQR8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="603" mass="70431" checksum="7B19605EBD369EA5" modified="2023-09-13" version="1">MNDCLFFGLKEYPKLFKNKQEKITKPIQFKFENENENENENEKQIKQISTGFYSTIFLFENGKVIEYLNRSRNSNENPEKIQIENIQKVTVGYANEAILTLEGNVFAKRYDANTENPKEFINISSLIEDKNDRIIQDIISGGFTIYLLTSNQNVYGIGSNHSCQVGFLSPNKTEKPILMMKNVSKIFSGNSSIHVFLLNSNQELFGCGNNGHGQLGLGKSIKEAIIVKLTKIQNIPKGKIIDIQCGFYHSIILIEEENQNENPKRKLYSCGDYQYNGLGKNQDSYEFTEIKSSLFENNDNIIDFSVGNFHTLILTSKSKLFSFGNNEYGELGNGNTKSQSIPIQIELPKLRFNEDISNYHISCGYRNSFLYYSPFLSFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQNENEIEKLEEIISNKSIKESNQIFEMIYSNRIINPKLYFEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFKIQPKTKETSDCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQZ2</accession>
    <name>A0A9Q0LQZ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras di-ras and rheb family members of small gtpase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQZ2"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="299"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="408" mass="48100" checksum="08223D151494E053" modified="2023-09-13" version="1">MLTDNKEEEGQIIIGIFGAGATGRENIALRFNQDFFSEVYDPVIEDTFRKTIEIQGEQVTIQTIVTAGQEEYESFWPPIAHISNCLFFVYAINSETSFKDIPSRYSILQKSFDNQEKFDLIPKFLIGNKIDLENEREISFQKGQDLANKYQMNFFEVSAKTGQNVQELFENAVLEVLKTRNYLFKFLQTFQQEMIQFFERKEFSDFSFDFQDTNQESIPLHSLILKYRIGKDYQQKLEKLKNKERKDVIVFLQLIYSGLDKLKSIKTRELSHESGIKIKIGREKLIEDMKKLYSEEETKDFSIIVQNKEIKVHKIILALRSEVYREMFNQVKDNSGKVKDYTNSKFKTFKTLIQFFYTDTIKESISLETIQELKEAEDFYQLHPKSSLSAQLEYFESKKNKNKKCSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRE3</accession>
    <name>A0A9Q0LRE3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRE3"/>
    <dbReference type="OMA" id="FRRKQRH"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="212" mass="23801" checksum="AEA490BA8ABF1E75" modified="2023-09-13" version="1">MNRLKIAVVGSGGVGKSALTVQFIRGEFIEEYDPTFEDSYRKEAEIDGETCLLDILDTAGQEDITSMRDSYMRTAQGFLLVFAVNSRPSFEHISPIRDQINRAKDAENVPLVIAANKVDLEIERVVKNDEIQSLANDLGVAFFETSAKTRLNVDEAFFEVTRRITKKSRKSSTHSNQSTQNLPFSRSPKSKKNIDSNNPLNSSKKKHKCILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRI6</accession>
    <name>A0A9Q0LRI6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="18">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M0811_00514</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="18">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 18">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="18"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRI6"/>
    <dbReference type="OMA" id="LDRMLMY"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000011">
        <property type="entry name" value="Folylpolyglutamate synthase/dihydrofolate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="14 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 18" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="21">
        <location>
            <begin position="58"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5077194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="492" mass="55231" checksum="1977494F1B527F3A" modified="2023-09-13" version="1">MQIKTYKQAIERLSKLQSNQKARIRMDSTFSGHNSLSEMDHYIESLELSLQKLSVIHVAGTKGKGSTCAFVESILRNCGLRTGLYISPHLVDIRERIVLNGNMISKEDFAEHFFAVYNKLEQTRTPDFPELPSFFRFMTLFAFHYFLHQKVDVAIIEVGIGGRYDSTNVVFPTVCGVSSLGFDHMSILGDTLDKIAFEKAGIFKRNVVAVTSPQKPIALKTLKETATSVGSPLFLVPDLSAYSSQNEIILSLEGDHQKINASLAITLAKFFLQLTFNVVDDLTTNLDWQKYLLVQPFQKTDEIFQEDLSTDSALEILFANSEKGLSTTSWPGRCQVCPSKKSENVIFYLDGAHTDESIGIAVNWFANKTRTNETETTENSSVKILLFFCTSDRDPKNLLQPLIKMNIFHHVIFSPHIPVKKAAKIPGNWLDLMKEIWESSDPKAQIYVEKTLSSSLSSIYSISENFQDVLIQVLVTGSLHIVGDVLSVEHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRY3</accession>
    <name>A0A9Q0LRY3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRY3"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="22195" checksum="F941451B794EFB4B" modified="2023-09-13" version="1">MGSCSSKKNVLSTEETHYSKDELKVIDNDFSYHSSNGKQMSKDGFRDAFLGLVSNGSNNLFTDQITKAFSISSQIDHNQFAIGFSKCSTSNRDEKLKFVFSIYDIDNDGYLSRAEFLQMLECFFEVNRNHFGKSFDTHDESTRYIDRFFKEVSPLMNDRISYNEYKTHSLKNQLLASVAGIFWDVRKIVQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSP7</accession>
    <name>A0A9Q0LSP7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="5">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_05105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSP7"/>
    <dbReference type="OMA" id="DILCDER"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="7">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="8">
        <location>
            <begin position="485"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5078317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="638" mass="74745" checksum="EBA46D295A44C44D" modified="2023-09-13" version="1">MTFYQELCLDILDSFGNVTKTIAETLLRQGASQISDISKATLLPPHEVRIGLATLYTHNIVSKTKEGYKIFPLHILSRLRFPQFIHLVKKKYKKKSHPVIVEYLLIVGTSSAAKIIEDLTTPNNKYTKEIFTQIEIQQAINELIRDLLIIDPSYSIFTQIQNPDNKRFAEKKTEEIEEKAKSKKRKKKEINEYEPIKIEINTETVRKFHSLDFDAKNYLNTINEENIETNEEITNLDNQNEMKENVEKSKKENKEEDEKNKENEDEKKKSRKSKSKKSKHKHEHKHKHKHKHSKSKEKSKKEKSKKKKIDQIKSKMEIIQENKSQVHIDNSAIILQINLSHFITLYRNHLITKYISNTVREDIGEAASAILDIVNFAEMNYKLTNIKGLEKYENLHFQFSFSRKCLLKIFPESNSQRPQHNKIIDILCDERIRLLRDIELESLLQSHKSKNNSKVFTSEILKQRSSNLVFDLSTISQKMKERILSGIVSKRFGSKSFRIFNLLLRKGMLEEKIIANMTLFSPQETKQELYRLLQEKVVFLQPIPRSSDNSHARALYLWKVNFDLFAQQNLDKIHQSAHNLLIRMTYELMKAENLNKKELQGLLTDEDKNNLSNLGNKVMCLENAILQLDKEMTVLRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTD8</accession>
    <name>A0A9Q0LTD8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_05149</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTD8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="RCC1" evidence="13">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="13">
        <location>
            <begin position="190"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="14">
        <location>
            <begin position="346"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="455"/>
            <end position="462"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5078361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="607" mass="69001" checksum="ABCCCE170EAD99A1" modified="2023-09-13" version="1">MSHLFISGTSSSSFFLKPVVKFSGKKNQIKNISCGGSHTAISLENGKIIIFIQKKFSEMKKNIKSNQDNFSENFEEKKFNQFNGKQILMLSSGATSLLALVEGSVYLLDFSFNFPNKFEKINFGKQFKKYLSNCCWKGHLFAWGNNNCGQLGTGNQEEQKNPIEIEIKNAGPISEVAAGGQHSLVLTTYSQLFSCGKNQYGQLGHGNKKDKSTFTEVLFIPQKERIKSITCGNEISLILTENGKVFIAGRGNGTGLGNLEDQPIFQECIFGKNVEITQFSSGGAYGQSFFVAKSILSNIYGAGGNQYSQIKNNQDEKSELSPVRIPFPDEFIPISFACDENQEEFLGNFAQLPNEIIFKILSYLDAEFLTRISRCSKLFKVYANQNIFWKSLFKKFCGKPNPLELKIIENPQNLDCGYYEACLFRYNNPVYLSNDGKYKIFKWKAKKEGRLLTLGLDAGGKTTMLYKIKLWSNITTIPTIGFNVENFQAFGFEFNIWDVGVADKGRPLWRHYFQGTDCLIFPIDANDDQRFEEALSEIYRCAQSEQLSNSLFLFPFTKIDIAKNFSLIERIKQFDFKRIPQYHNFLNICTPRAEGLYELIFWIAEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV89</accession>
    <name>A0A9Q0LV89_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV89"/>
    <dbReference type="OrthoDB" id="10001977at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="40"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="305"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="481" mass="56650" checksum="488915A2A1052D38" modified="2023-09-13" version="1">MENYSNLEKLSFNLKKLFQNQNQNQNQNQNQNQNQNESYFDFEIICEQNQISFKTHKSILSSRSHYFKSLLKSKMKEYQENKLILKDVSSSILFPILNYFYSGKIEINLENAIQILIFSSKYLIDELIEISSNFIKNNLQIETIVDVLKLSESMNFNQLLDSSYQFISKNFEEFIKTPFFLELEENHLNSILSNDGILINEFEIFQSIIKWGKHKLNIKQELEKEEKEKLQNQISNIIDKIRFIDFTKKELADILKEELIPKQISEKLIQFQKLEKQKNEKELNEFIENESSFIFKTRFTFDSEIIQEKEHFKKLKEWTNDNYFFSKMKKGFSAKKDGFDCKIWHKAVDDKGKTLIIIKTKDNFIFGGFTQIGFKSGTPVTINDSNAFIFSLRNDKNDRKPEKFPYNNDGYAIYSDFSTYGPVFGSGSDLVIESDLKKGWLNFGKSYNLPKGIKYGTNEAKSYLGGSYNKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVG7</accession>
    <name>A0A9Q0LVG7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVG7"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="104" mass="12444" checksum="E818D9C7A9986270" modified="2023-09-13" version="1">MKNEIIYNFFKEIEIDSKWIENKKGRKGIIKDLSKLYKENETKDFTIIVSEEKQIKVHKLILIIRSELFKAMFELNIQDLSNKVHDYSKKSNETIQSINLFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVS5</accession>
    <name>A0A9Q0LVS5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVS5"/>
    <dbReference type="OMA" id="MINMAVR"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="57"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="322" mass="37321" checksum="D22420C3CC692798" modified="2023-09-13" version="1">MSETSQTISNLKKLILTGLGAYITSQSIFRIEPNQNGIVYQEFEFSKLTKLYENIKSTIKKKPQREIEKAHQINRVVGSGIHLKIPFFEKVEKIDITSIPRYVPTTALTKSHQQVNITLHVCSRPIPSKLIPLFQTYGNNFHDRILPSIARNLMISIVSKMKTDDIVQKFDQFKDEIEEKLKREAFKYNLQIDEVSVTHISFSQEYTQAIEKLHTSKINLQISESNKTIAKNQLEMDQWKIRSQSDFISKVGNALKKNPDFLIWKRMDLAGKFSEILLKGKETITANDLMKSFESTKKGIEEFDKLFEIDRKEENSDSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW33</accession>
    <name>A0A9Q0LW33_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nnp-1 protein putative nuclear protein 1 nop52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1778" mass="210100" checksum="98105F6FFE9493C6" modified="2023-09-13" version="1">MSININNEQKILIWLQKKLKKEIPFEIKTKELFKYIYEYAYLNYPDSIQLWQKSDENKNMENLLILSRKNGIPEQILKGVSNFERKYLFKLLLELKKNLRQETQEKIIQDSNTKKSKKIKFRRVKNATPNSSKIRRVRIIKDTHVKQSNKESKGQKILEFKPQNPNENTGNPTQKKFRYIKRIKKSDSTNQEINLTNINENKEKNEPNDDFDDEFEEINFALPIQSNKNQNQNQNQKSLENEKEKIAKEIEKLKQEKERIQNQSHSNIYLQNEEYQKFGIILDSNANHLIYKTNIDGSNIIAEFKNDGNPVVLQQQFTNFSNINSKLVMNPGLKKKVAKIHQKIETLLNQGFVDFNFKIMKDKIKSGVIKFRQNKIKVLSSSSKKIFDGPYSRDQRIFMHPKEFNKFIFQLNSTVQIVGLIEDPFQRDVIVNTFISFRDKALNFVNNKNQHYIILSNSSYEYLNTNELFKLPMKQNENENLNENEFENENQNENQNENQNQNENQNENQNENENENQNENENENQNENENENQNQNDHFKDPKISWVSTYNYLKKEQNKESDKDDQIDQNSNDLSKSFQVGLINSFTEHIGYATITLFSNHFSVKYLTHVLYRYYSPFSRLIFAKEEDLFCQFNIDEYYNFKIQFSNIDKKISFIKQFHFRRYIHFGSQMEKFIDKKQPAVVFPCFAFAGVDDEHKTKVKIDFLIKSYFFSVSTSHSEFKESSFTRDYSVESYVEKITEQENQVRLIFENGNQMNLQFGSLEELQKFQETFEQYKMRFLSHSFGVKFKQFNCQMVYKEEQFGNVDTIITFDKLTFYKQYKAITYALQDIKITEKSNSSSLELDLFEGSKLVLVFAEPSDREKFAKSFEEFNISKNKSINEQQNLQKTSPNQQENAKKEAQVEAGTQFNIHFYSESGKYLTFGKLTISTEFLILTKQNGEEIKKKIIDSIIHLHPTNLDGCHIEFQGEKFGVIIGFQDSNRQEFSTLFEQRKNELMKIENEKKAQEKLSKKDGLFLDSSEDLEVEERDTPSFEFPIYFLNDKYEETEENIIEITNKEFIVKSKENQVIYMQSLNQKISISSSSKAKNIHRMTFENEKFYNFKFSGNKKYPDFVQVLKQQRRNYLKSNSRRLTERNLPKLSPTILSNNTEDEPKQYPVLILDNNFELVEKALITINQDEIILKKSNHETKHSYNERIKFVFHPTENAIAKLSFEQGDSYVLSFENSQAKFSFFNAFKKNKTQSLNLSSFQENMDPSPRDLARSSTSITPQSMQKFNSEQIEKRAKEDPIFPITEKTYKVNFLNGDYQQIDSGTFQVSNHEFVFVTKKKGVEKKKYDQSVKLSLYSKKFNIVNIIFEDDKSTIRISFENSQERIHFFSNFRKKRTFSMIFSRKKPAKFTYVDDLQIQEQPKKDKNKPSKKSEFSPQKKWTGKNSLFKINILNEKFKKIDRGTIQIENNELLLKTPKRDIKTTYNENIELTPIESKKKVAQLSFGDGTKLLISFQKPKDLSSFFGSYKFQRSQSMSHFSIKKSFSIENANLESQNWFDPISEFDVDIIDTNFKKLDVAKIVLGEELTFINSKQSLKFSYINDDIKLLTHPREQIARLLFGKHSDNILLFQSADERTVFFRNFKYQRFLKKKQLGEFENQLESKLNSNSLSKNKNDKQNDSNNNQKDEIRFFFVSILKTNEERFLPKEVNFQILNTNLVVRFLNQKKYQSQYSYEITTNSTILQSGSKRTFFKINVGKCEFIVVFINFETGMKFAQLFKEAIKKINSENEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWQ0</accession>
    <name>A0A9Q0LWQ0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_14314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000020">
        <property type="protein sequence ID" value="KAJ5079939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWQ0"/>
    <dbReference type="OMA" id="PDHSVQW"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5079939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="430" mass="49646" checksum="ECBDC8C24EFA01D6" modified="2023-09-13" version="1">MSLLKANQLNQLKVILKETSTFETIQNIFGSSFPRNTHFAVSCSLGMLVRNDLLEPQEQIVAIFLLCYLFSIEQQNQQNKKEDQIISSFIVPIIELVSRVSSQNQSERIQGYFALIFLDNIKSDFLKKTSLQILDISESDWILFTSHLKNESPHELLIKNTLDLTKNHNIGFPSQSPLIPDPNPEPSNSLFTDDDFDEVNKFHFVSDEFQPPFIQPAPGLLGISDSEIQWIDFENDHFKSIFDYLLEEQSIETQTKNLIEKSSKFPLSEEEENLLKILLQEDPQLFDGIDFTSSFLSQIIESNKMIAIEIIKNLFPKQTKDLLSKLEQINLSPQFLEVISEITKSLNLSLEFISKFILNSIQNLKKIQDQNQFQTLMHYFCDFVDILLKESSFSKKFPQNIIGELKSFSLENSNIKKSTELFKTLNNFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWR6</accession>
    <name>A0A9Q0LWR6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWR6"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF370">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="120"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="359" mass="43749" checksum="AB42C4FDD2EE5A82" modified="2023-09-13" version="1">MKNSKKILNLISSWITYFPYRWRNQNELIQNYQILLHQILIPRFSEFKIYDLHLENFLDSKPKITDNYKWLHYKFTDKPILEDEEKKQQKKYPKENHKKTKRKIKKNEKTLKHSILDTLSETEFAEQLSIFQYDLMTNLDPDELLHINWYEKFELHPTLTRIVYFFNNISFYVSWRILKEKNVIPRSKMMKRFMKIFYILIKMKDYQSAQIINSGVQRASIYRLKHSKSLLSKKDFNLFDEGNNLLTPNSSYMNYRDEIRNFEGIQFYIPFLSVNLTDLTFIHEGNQERINGMINFNRFRFAFHSMKMAFSSLFLDSNFPSPIPEIQREFNLITKIKSEKELFHLSLKREPREPDRYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZG5</accession>
    <name>A0A9Q0LZG5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000004">
        <property type="protein sequence ID" value="KAJ5080685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZG5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040259730" description="AttH domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47987" checksum="85AE9C811E9A8326" modified="2023-09-13" version="1">MKSFLIIFLVIFSVTFCQTKDLSFANDGIFNPPTYYERLRLLEAVATRPFYQWYYYAVSDYDVGVEFAMSIGVSKSSESGSKKNEGIYIMFCEVDPKNDKTFAKIEKYPLDDLSFSHDFDISVDNQKFGIHPITNNSYKIWGTLNDPQHIWYSTGNSSDLDISWSLNIQRIYGWYGQQDLENMYYLYGFISWNTYSHDSLVSGVVTIGSKQYTLSPNSRIYCDMNWGDYFPVGPTKEFAWGWYKVLLPGKTPAEDVSIIAGTGLTSNITLFDTVEGCFADVELGKLGKREGYRFLEGWATTPDPVVLLATASNGVFKNFSVERTNWFNYSDDLGQAQIPLTQYVYIASDTLQVSMTFQSTPELYNRLLFPQEDYIFLILKLLGFVTCHIVITSTNGTTKTLIDEVIDDAGLEFGYKCPVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0M027</accession>
    <name>A0A9Q0M027_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0M027"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="571" mass="67507" checksum="0A68AFF241E38274" modified="2023-09-13" version="1">MNSNNPFEFQEKHNQIYNFFLGAMGKRQDKVDKKYQQYCASVQNLLLKKKWGSNTIIKTQNQSITSKIFFSRDFIKLVLFNENGEKTTRNFSYKQIIISKDKNDENSLQLQTDTSGRIHIQFESPTQRNLVAEYYFIVRASMLIQSKLELIEEISNETLLFENDFLNGIVIYQWGMKKNVFQILQIENGLKKNAEITLKKNDIIILMQEKKQKIPTSLKNKLFLHKSNAQRFVLLSQGKSLEFECKTGKSRDFVVSLISLFLKLPSNSSKKIFDSDGEFRINFAKLFQPSNYSNVDNKQHVINEMRNIIYSRYFKKQVNFFIEKIPGMIIMTDDGIQLIFNQNHQIKRKFENCSLFFNRKDLSVLLIEIFDSPIIKRITFCTDEKQDTDLIVNVFFFFKLSQKYDNFVWHEEMICTLDYEMIEMFYGQSNTVEITPISIGPEKLLKRSDTLKTDRQKFTFISERKRLYSKRIQLKLFLHKTQVNSFDDNAILSFESGFLTVIIHNKTVLNYLIKPDLEIQNYLENAMNILIFSVPDTFELKIYDFSDEFIEMKNEVRKTISKLLSKEDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4A9</accession>
    <name>A0A9Q0R4A9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras and ef-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4A9"/>
    <dbReference type="OMA" id="CLIVRFS"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="167" mass="18929" checksum="6A0F1E3CA761D024" modified="2023-09-13" version="1">MESLKLVLIGNSQVGKTSLLFQFCEGKFQPTTISTTGVDFRFATIYYKGEAIKLQIWDTAGQERFRTITSSYYRDCDGVIFIYDISNFSSFQQLSYWIKSVNENAPPNVSKMILGNKSDLENRKNVPTRDAKELATSLGAFFFEVSAKSGDNVEPAFQAFSQFIYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4C4</accession>
    <name>A0A9Q0R4C4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4C4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="282"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="456" mass="54541" checksum="7CC7EA1BAEB4A6CA" modified="2023-09-13" version="1">MEIFLFENQENLLQLLEISIYFKLDLLKEIIQKKISNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNQRLKGKKEKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIEKKEKEIEEKWKKEVEDKEKENQQMKIEIEEKWKKEVENKEKEIEDKNKEIEDKNKEVEKMKEENEKMKPIFDQYQMEIELRKNFPQFSDSEIIKDIEYVNKLQEWINDNDFFSKMKKGFSAKRDGFDSQNWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGFNGNTRNINDSNAFIFSLRNDKGDRIPAKFTYNGKVRAIYSYLSYGPVFGNGADFGINSDLQTGWSNFGCSYNLPNGIKEGTNEAKSYLAGSPNKWVVDELESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4P3</accession>
    <name>A0A9Q0R4P3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000131">
        <property type="protein sequence ID" value="KAJ5067272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4P3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="481"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="595" mass="69359" checksum="1D4DA165C49E517D" modified="2023-09-13" version="1">MNEIIFFGDNQKPKIIKNRQEGLTKPIQFKFENENENENEKQIKQISTSDFSTIFLFKNGKAIEYLSENDSYQKPEKIQIEENIQKVSVGKQNEAILTIEGNVFAKGRYINSKRFINISSLIKNKKDRIIEDIVSGSDSIYLLTSNQNVYGIVSNEYGELGFDSQTLFKAEKPVLMMKNVSKIFSGNNSRHVFLLNSNQELFGCGYNEQGQLGLGESRKEEKIYKLTQIQSIPNGKIIDIKCALYHSIMLIENENENPKRKLYSCGYSQFNGLGKNDGDTYKFTEIKSSLFENDDDDILEISVGFSHTLILTRKGKLIGFGYNEYGQLGTGDMKIQSIPIQIELPKLRFNENISNYNIYCGSFKSFLYSSPSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRRMLLSVTNDKSNKVTDYSELSNKSFQIIEYWIYSNQIKEEIKITQGIINEIEKGIDYFQLNQTNPNLFDLLINKFNNQNQKKENCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R570</accession>
    <name>A0A9Q0R570_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R570"/>
    <dbReference type="OMA" id="QNQAQKR"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="130" mass="15837" checksum="98C19BA89407A6E4" modified="2023-09-13" version="1">MKIKIKFKIKIENQNQNQNQIENQNQNENENQNENENQNQNENQIKNENQNQNQNQNENQNQNQNQNENQNQNQNQNENQIQNQNQNQNQNQNQNQNQNQNQNQNQIKNENQNENQNQNENENENENKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5W4</accession>
    <name>A0A9Q0R5W4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thap domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5W4"/>
    <dbReference type="OrthoDB" id="7903616at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="226"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="848"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="870"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="913" mass="108481" checksum="040820AE917BC1EA" modified="2023-09-13" version="1">MSKKSKTIRIRLVTLNKLQRYGKEKESPDKILTRILNKLEKLKIFFPNNENHNLNQEFSQKSESEMKDNVEPQPEEKKESNENQKTSCQIFDLFEYIYPNEKLITIFTGLEKVHLDLIFDRIRKLPPEKIQKYHLLDSPGKQGKKVNLNNRILLALIFLRYALPFEFLAALCKITKGTISKYFKKILPAIKEVLEDCINWPNNQELIKNELYWRKKQLPNVIGVIDGTDHPRPRVKAMESIFWSIKRGYSSIKSIVVCDHLGKIIFFETGFPGATSDSRAVEESGLSKQLKEYRVLGDKAFSHEYAVVPLKNSKKRVFTDQEKERNAIINQYRSIIENVFSVLKRFRVTSVKVQCDLILHQACLWIVASLYNLKIQKNSLRNQNRDPKAQKKFEKMRLYNQKTREWKKKMKELQKNFPQRRKISSQPTKRVSQNVLNPSIVVKNSQKNIFQGKDFDDSKSINLIENSQQDNQNIIEMCNSQEISGLPEITKEQTPEGKFSSIQKEVVETAIEQILEHSLKLFRFHITPSDDWQKNLDIRGWLDYSDIYNGFKFLAPSSQIIETQFVFYTLFPIIEILNRWHIPSGSIDQFTDQLFTQWTNLWSNFEKIEKTENFLSSFQEFEKNHEQMGEIEKYYRFIQSIPENDSNPLSENKNNLLLIISPVWHNFKLWDQLNEVNDFFNTIQREKTRYINVIYYRKSHFILYHIDLQLHSLSILNSLGNYQRNQFFLDASQLSFCFDFFLQTSFEIQDIIRIPIQKDGSQCGIFTLAFLWVLSEFEISVYDLVHFLDQTTIIQLRYLLLRCYLFAKNSKRKLMKFKDLKLLLDENPDGKLIPSFFISKKRKEKTKMNLENKEKTKMNLENKEKEKKQKEKKQKEKKQKEKKQKEKKQKEKKQKEKKQKEKNKPPKKSRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R610</accession>
    <name>A0A9Q0R610_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R610"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="486"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="610" mass="71333" checksum="6D3D3D4F185882E4" modified="2023-09-13" version="1">MNEILFFGKNENPKLFKNEPQEIKKPIQFKFENENENENEKQIKQISTGDFSTIFLFKNGKAIEYLSKKDPNQKPSKIQIENIQKVTVGSQNEAILTTEGNVFAKGYDINPKNRKKFINISSLIEDTNDRIIQDIVSGLSSVYLLTSNQNVYGIGSNELGQIGVDLFYKTKKPILMMKNVSKIFSGNYSKSTFLLNSNQELFGCGYNEYSQIGLGESRKEGIIDKLTKIQNIPKGKIIDIQSGYSHSIMLIEEDENQNQNPKRKLYSCGFWRYNGLDKDQDTYEFTEIKSSLFENDDNILDFSVGSFHTLILTSKSKLIGFGNNSFGQLGTVDIGNKQILIQIELPKLRFNENIYNYHIHCGYFNSFIYYSLSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLKEIISNKSIQESNQIFEMIYSNNSIINPKLYLEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVKNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIKTGIDYFQLNQTNPNLFDLLINKFKNQNQNQNQNQNLKNKKEKCSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6B3</accession>
    <name>A0A9Q0R6B3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_12571</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6B3"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000037">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="117"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="556" mass="64544" checksum="0E0EA8B513CF67AD" modified="2023-09-13" version="1">MSSRQQQEQENKEQENKDNQDNKDNQDKDNKEIKQEIKQEIKQEIKKDNKEQERKKKQKKKKATFQGAKDQEKVTFSADKIKEFPVWYEGILEISELVDKRYPIKGMPVFRPFGCFLETEIMKLIEYEWDSQDIQRVMFPTCIPKDFLEKEKEHIAGFMKECFWVLKGGESELEVPFALRPTSETAMYSMFALWIRSFRDLPLKVYQTCTVFRYETKNTHPLIRVREIPFNEAHTVHETEKDALENLEQAWVGYRNVIEDKLGIYGLRIRRPDWDKFAGAEFTDVLDIIMPDGKVMQTVGAHYLGQKFAKPFQIQFNDRKQKSQFAYMTCYGVSSRILAAVVSIHGDNKGLIMPPLISYYHVVIIPILFGNKAKQKMIIEKAQEHAKMIKKAGYRVKVDDSQQSPGNKYYFWEMKGIPIRIEVGPKDIQKQQVVFVYRINGEKKEVKEEEIISEIKSGCDMTQEILSKKAKEFHEARIKVCNSIEEVKEALAFGGFAKIPFHSNGPDGKEAEAVLKEQTGAEIRGFDPKEAPPANGTKCIMTQKDAVCWAYVARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6W8</accession>
    <name>A0A9Q0R6W8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6W8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040473729" description="Fibronectin type-III domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="99090" checksum="806E5749F6FAF7BF" modified="2023-09-13" version="1">MKSILLIFFLFNFLILINSIQTQKTSRYYSYEDEAYIWNLIDNLTGTNQFGWSVSIYENVTVVGSPYVNQAFIYRYNGTNFELEQTLNGTESSNFGFSVSVYENVTVVGAYGSNKTYIYRYNGSIWNLEQTLNGTEGSKFGWSVSIYEDVIVIGAWGENKTYIYRYNGSIWNLEQILNGTEVTNFGGRVLVYENVTVVGAHLSDQLFIYRYNGTVWNLEQNFTGTPGSKIGWGVSVYENVLVVGAPGSGQVFIYRYNESIWNLEQNFTGTSGSYFGWSVSVYENVLVIGAYWSNKAFIYRYNGSIWNLEKTLNGPDFFGWSVSVYENFTAIGSTFESEVYVYQFTFIPQVNLHNCSSLFSSFDCYWDQIQIPNLKYQINFGYDWIDIDSPILKDGNVLYQLFNSSFNSNITGNEYYTIQIQVCDIESLKCGEVSSFVNLTTKIDSVKDFQLVDSTFYSVNASWNYPNVVIDGGIPHLDHYNFSYFNTSAPGSITSTSIDNSSTSYLFDIECGNDYNVSIFGCRTPECEAEDQGEVVESSISIPFENIENLGCLVSVSLKIFCSWTKPNNCKDPSYYNFTYQAISGNDSENYHLGLGNKEFIAKIPNQEYQINVSACNSMNKCGNISTTSVTTGNLTTSPTINQAISKIEEIELNFTKVSNANNYSISISLNNETNWQNFTSLDLSGSEGIGRISGISGNIEYNISVCGCIDLKCEIYYLGDPSSFTLETPKLGNITSLDCYGIVNAFFCSWDSLNLTDGLKGYLFRYNSIMICLSSSINYQLISGVNGGENYDISVYASADSNCYYNEYSGISSNTSVSPSLPTQTKESASKTPVIVMGVVIPILVIASIIGFIILIKKQKKSIKRIIKEREKELEKSGGIEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7C9</accession>
    <name>A0A9Q0R7C9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper transcription factor f-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7C9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="81" mass="9704" checksum="CDBA7C056385284E" modified="2023-09-13" version="1">MAAKNFRQRQREQIQELEKKLEELEKTNRDYRTRTDALEAEKNILVSQLQYFQNFMTRAMTTAYRNSPPVQKPDANPNKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8A3</accession>
    <name>A0A9Q0R8A3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fip1-like 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8A3"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="358" mass="42317" checksum="15F1C8ECE2F3D418" modified="2023-09-13" version="1">MEDRTQIKKKEAEKETNSTKLPAKFTTYKSGLKLFSDFDIDKLQDKPWTNPGADPKDYFNYGFTEETWKVYCQKQNDLRQRFAIPDSPIIQEEDKHSDKPLNKNMNIQPNIGPPFFPSGISPPNIFSHNPNKQEMKMDEKKPFSGQTNIFSQPLNPFINPPFNPPFNPPFNPPFNPNINPNINPNFNPALKNQPPWVPPNILFPIPQNPFYNPNFKQNLENPRRWPQRFPPKQHYNDLHSRGPRNPNFHNQDTKGENQYSHNEHKENQTESHSSQDRYQDYGNKYPDKNQERTNDDRSKDRNPHSHQHSYSRSHRNSREQEYSQSKSRNGYGYDSSHHSHNYSSHRQRRSPSHQTREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R978</accession>
    <name>A0A9Q0R978_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R978"/>
    <dbReference type="OMA" id="NGHEECA"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="23376" checksum="8366BAA8CA608648" modified="2023-09-13" version="1">MQQQNTNQSTQNTQNNTNSNENQNTNQLKQNEIPLHIALKNKYSKEIIELLISKGSDINSKNNENEIPLHIALKNKYPKEIIELLISKGSDINSKNNQNEIPLHIALKNKYPKEIIELLISKGSDINSKNNQNEIPLHIALKNKYPKEIIELLISKGSDINSKNNQNEIPLHIALKNKYPKEIIELIPKDYIFKKDQMILIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9F9</accession>
    <name>A0A9Q0R9F9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calponin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9F9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="119"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="682" mass="80572" checksum="B328E607CD07805B" modified="2023-09-13" version="1">MIAYYQNNPNQPKRANTQPNFFTNTEPILNRSFLRRPTLELARIRFEKKLKKNGKIEQTNNIFNENDENKNSNPKLNSKKQENINLLNKTLSYSHNEQNYSPIRSLTIERKQKKNQDLITKQNEVMNWIENFLGKKLFQHSPLALLKEGKILYEIIFKIKNSKIGSNPGNTKENIPNKSIQYISTFLQECESLGIAKSDLFTVSDLIEGKNMFQVFHTLDILKMHYQKNYPEKLNENSSESSDNIEPEIEADDEFEDLSFYLENQENENENENENSQKNFKINLNNNKKNGNENHENGDEKKTNHDIDIDIDNDIDIDINIQAFETPSLEEPIHEYFEDKKKKTKLHSRSFSHHLVLQTRKNKHRFVSKANPQKESKTQQKTRKQNIKANNPNNKRFSLFPQQKKNVEINVYKFQLENLIDKMKNNLDLLKHQEDNSVNKLRKLEKSLIEDVENEKISKVGNRRLKYHFKFGYIYSSRIKIGNGNDLIEKIRIQKEPNDKKEKLDAISQIAEINEFTIKTSKLLNSIFNSFSMNLILKSKDDEDYFFEPKNVESQELLISNKFGYSSLKHFQKFQGIEDNQENSQQYQSFLYIFEMMDFISTKLSEINSNLSRKTIWNDSIQKETKTKVLKTISRYLLRVLLYLKSQFKEDFNDNLLKNYIDYSNYTGLIPDELIKNVISKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAC4</accession>
    <name>A0A9Q0RAC4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAC4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1111" mass="133042" checksum="48E353FD80C477D5" modified="2023-09-13" version="1">MDSIKINDTLQDPQETNEIVKIYEHPRNTYEMFVNSFFQKNYKSGTKEHIFTQAQEMWRKKKKDSKFIEEYMTEEIRKHELEQKSNEFEEKKRIKKKNKMKIKKEFVTQLFLRFVPETKITPEMIKNRKVAKSLESFATHWSDFESLLFSYREGLKREPQKETVLSKSISAVKEKEIDIQHSIQQICFYFEGKSKKKNRKQKKKFFQDFISSMQKFSTIVLNAKKRLHLNENFNENLNEDFNEDFNEDISNKFINQFQNQIQDQNGIIEIQNKIQFNQNINQFNQNQFNQNQFNQFNQFNQFNQFNQIKIIHNQIQIQNQNINQNINQFENININQNINQFNQNQIIHNQIQIQNQNINQNINQFENININQNINQNQNINQNQNINQNQNQNINQNQFENINQNQNINQNQNQNQNINQFENINQNQNINQFENINQNQNQFENINQFINLNTENFLQNIFNHNLKYKKGNQYLNNKNYLENWDKCEIVGFNTFSWDIVEENLINLINIGRELFPLPLFSFFSFVQEIQLFSLIPISYFINRFQIPEELIDLFEFQVLKICPIFSVRTKQNRSYFLNIYKVDETPLFNQKNIQNLISNSNVYIEPKIFENSNEKNIAIKNSNKHDYSKKFRHFALQTIIQKSISSFSNLQSIHNLDFLINSLEIPNAQMNKNEFIEKEIIQQQLETIEESKDIETNKEDFYADSQIQNLLEFSQLHNNDCILITYGNVFSVSVIDSKNDKNSKKSHLFVDQHIPDLDINYSQLEHSKFLLFMELPLENSSFNQDQNQNQNQIQNQNQNYYSYPLYLAPCNINISPQTIATRINSLKKIILKSQKPIVNLIVESGDPESDPHSLLTLFYFGRLWKQLDLEFLNIMSYFQKNRPDNYQNQPNHHNFKDLRLKSKLLELFGSDLSFLFNQKNQENSGKTTNNSFQNKENIKKEILDNQRLYHVEFFSKEEQTKKEMANNIPSEYDLVKMFLTLGSDEIHAVPRFEQIQQEFLFYFQHIHMNERFLSFGKCNNFSCPHCEKNGVNSQAGKFLLDHFHVLIPSSSQNQFPQTYDSFQEKLKQKDEIIRSNNYSTCKYSNCFYYSLKEDVMQKHEELFHIKNKFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAF1</accession>
    <name>A0A9Q0RAF1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAF1"/>
    <dbReference type="OMA" id="SERENCK"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="827"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="993" mass="111214" checksum="61F90DC749248E4F" modified="2023-09-13" version="1">MNSKSIQKAKNKNNKNSKNEKKEKKKSKSKSKPKSKSKSKSKSKSKSKSKSTPKSTSKSISKLKPKSKSKSKPKSKSKLTSKSNSKSKPKPKIESETESTSTDSELTSKSKSKPKSKPKSNSKSNSNSKSKPKSKSKPKSKSKSKPKPKSKSKLTLTSNSNSKSKPKPKIESETESTSTDSELKLTPKSKSKSKSKPKPKSKPKPKSKSKPKSRSKSKSKPKSKSKPKSKSKLKSKLKSKLKLKSIEPKSTSKSKLKSKLKLKSIEPKPKSKYKSKSKSKLKLKSIEPKPKSISKLKPKSKSKSKLNSNSKSTSKSNSKSKLKLKSTSKSKLKSKSTSKSTSKSTSKSTSKSKSRSKSISKSISKSKSNSNSKSKSKSKSKSKSKSKSKSTSKSKSISKSKSTSKSISKSKSKSTSTSKSKSKSKSKSKSTSKSKSKSTSTSKSTSISTSKSTSKSTSKSTSKSKSKSKSKSTSKSTSKSTSKSTSKSNSKSTSKSTSKSTSKSTSKSTSKSTSKSKSTSKSTSNSNSNSYSYSNSYSNSNSNSNSDSDPNKYPIEYTTQTQFPNQNQNQNHYQNEYPNQFQNQNQYQNQYPNEYLNQNLNQFQNLNTNTNPIKMPKIGIVEKESFNQVNDMGIKKANIQKPIENIAENIIYPPIITKEFCKQNGLCWHFFEKGFCFKTCKKIHPDKFLICSNLYTAEGCTDANCKYQHPNPLNSYHLSKLETENIQLTFDSIDSVDDDPNQNPNQNQNINPNQDQNQNQNQNPNQNQNINQNQNQNPKKMSYSKFLFKTPFRTSERENCKEFEKNGDCNNLNCKYQHRCGPKNNYLDDSGKYDNYKSIPQNYTLRDPTEAEYFMIENIWKVQSEKQSTPKIQSIKIVENDFLETRFKHVLQKNSESTQFQGILWGFHGTKQDAVDSICKSGFDANFQNRNLHGKGTYFARNPNISVGYCDETNQMFLTQVCFIEGKYIYQSTHQFYIVPDVELLRPFALINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAH7</accession>
    <name>A0A9Q0RAH7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sterol o-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAH7"/>
    <dbReference type="OMA" id="KINIYQR"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="275" mass="33338" checksum="F154E8DBBC311DB3" modified="2023-09-13" version="1">MAVNAMKMHSFFFTNKQVAFRKGNKMESDDPDSSKKIVPKPKDCSFTHFSLFMLYPILVFEFSYPRKSRRNWLKLLQYFVMMWLSFFVTYMILNYKYVAVYQEYILTNFWLAVFKLGVSTLILYLTLFYGVFHCFLNFTAELLLYSDRKFYEDWWNVTSFEAYYIRWNTLVHEWFLRHIYIDTMRDIKFSKTNANLLCFVTSALWHEFILTLTFKMFRPYISVSMFFSILLISITKHPFFKKTGFGNLILWIGMTLFQSMMYAAYARSWYLLKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAJ6</accession>
    <name>A0A9Q0RAJ6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="IDVISEM"/>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="1604"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1142"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1228"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1398"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="485"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="600"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1050"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1999" mass="234877" checksum="EC3192AF14FC54F5" modified="2023-09-13" version="1">MDGLLEGIQSDDISIQFTSIIELNETISLSTEETMSGFSIDSFVPAITNLISIEGAPELNLFACRTLSNLMEALPNSTGAIAYSATQLLVSKLLAIDYIDLAELSILVLEKLSRDHYSHVIQQGALSAIMTFFDFFSSQTQEKAMAAAANMTRSIAEDSYDKVTEALPLICNQLNSPNRKIADLACLTLFRISNHFIHNTNMRNLLTDEMILRNLLEILKQEAENPGIITPATFSSIVGLLSDLCVLGPSVPMILFKLNIFQILHYIILGVSKENLENLEMSAKKKSHKKMRSTNQLYNIIVLINSLLPNLSNETIPRIILEYLESNEQKNTNFGYNSSYYNYQENHEARLKIIQEHPEFPKNFAEYLLEPLIFTYTEAVSSSLRKNCLSGILKIIYHNNSENLSNLLPIYSKSITSIISEVITQQDDNVQVAFGLNIAFILMEKLPEMFWSIFQREGIFEDMQSLVSKITQIIQNEKEKIYILSINIQKDKKELTIELDNVEKERNSLEKNLENLEVEKQTQIQSQEKELEEMKNNSKTEDEINSVAEEYAKQIEQIEQELSDAQSKTYGCNTRKTEILQKLQEFQEYQELIKKTIPEFAIEEDEIKKEEDEIKKEDEIKDNEMEIKKEEDEIKKEDEIKKEDEIKEIEMEIKKEDEIKDNQIKKEDEIKDNEMEIKKEDEIKDNEIEIKKEIKKEIKKEIKKEIKKEIKKEDEMEIKKEDEINDNEIEKEKEIKEQSLFEIFDSQLDKRTLDSNEFIILNIIMLEWILKNTQSFLNKFYGEEFKKKFGSQNTKMELLKELSTKLKNPKEQNETMKQIAEIFQKTSFSIHEIIHTGIIENLIEYLTNNLWNHQKLMNIQKETKENISENEFEWHQELIKNVKNFYKHFFSKIDDQKEYPANQIMNDLHEVLNKVEDFNIESRPEINLTNVCQSFRLFFQLSSEEYTLKKYNKSEISLNSTITPSILEKYIWENTKLPIDDTMSIIDKEIAGEQENRKQVVHEIFLDSLENNEYHYFKPEKFLVYNNIKTSLDIINNLLREKEKKESDQTNENQNKSQDQDQIYENPFKIDSLDQNEIDTPKDSKNSLNKLLEHIRSFRKDDDDDNDNDNSGLFGDSDLINEVISESQELEFNRVIEEIEKQEREEKEREEKEKEEKEKEMKIENENQIEIENQIEIEIKNEIEIKNEIENQNENQDEIKNEIEIKKEDQIENQIEIEDDMKIEIKKDDEIENQIENQDDMKIEDEKQKKELEEKQKKEQEEKEKREKEEQEKKELEKQVKLGRIFEQKQKLFVHLKNHKKELENSEESNKFHPLEMTYFGKKLKTNKNLVKQIYKIWRNQLDKEFESESFWDQVHMIEYKRKFPLPTGLIYCMKIQENDNGLISEIQNEILSGFYENQEKEEKEEKEEKEEIKENQEIQKEENSLDIFSKSQFLLFLKSKHLQKFLRKELNTEIKTTLLLIKLLEAINRTYLELTTHEAEYETERFSTSTQNIIQQNDFVSLRLTAKLVTQLEDCFGVYTGAIGKWIPYLLKSHFGFLFPFETRLRYFLMTIPDSLRTLIEFSSHLERHIEKFRNIDLGRIPRFKVRVRRDALLESAMAIMEMPQTLGRSELDIEYFDEIGFGSGPSQEFFHLVSQEIRKKELYIWLDQSEAKNEPKEPLYVESPNGLFPCPLDVSLANLVKKNQEKMQLNSNQDSQIEKESENTQNLVAEKTKEILKFFNFLGKFMARAIYDNRLLNLPFSPVFFKAIMNKELIFNDLKTIDPEFANSFSGLIELSSKYSSTKDKTLKFKGVELSSLEINFVLPGYDIELKPGGKDIIVTLDNLAEYVRLVVDMKLGKGIEEQIKWFQKGFNEILQLKSLQIFSFEEFDILINGCVEKWEPKMLMENIICEHGYTKSSEVVLYLLEFMSEMNALEQRQFLRFVTGSSSLPVGGIAKLVPHLTIVKQSTKPFENPDDYLPTVMTCANYLKIPVYSSKSVLKQKFTIAFSEGQSSFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB33</accession>
    <name>A0A9Q0RB33_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB33"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="48775" checksum="2065E8B1AC15769A" modified="2023-09-13" version="1">MQVNLNRKTGFIEKFLKKIFHNLIIQMIYPGVAKQPDSVEAMKKTMREFSIAIGREEVELYTTDHIKLEAQYFDINKCRENLNNKEFSKKWIQKITEELESYPEAMTRFKPDAENLADFFQLKLPEINYQKNKNPIKVACFCHGQSGLINTSPNRVFNYLLKGMSVLEFNYRGFGNSQGFPSYEGTCKDGIAACNWLIKNKGFEPEEIVAHGISLGVGVAAVVAQKIPGVNLIIDRGYSKLAWVGYDTIKLLFFLWLGKFWGFLLGFLVFWLVYFFTELYFSYPVEKIIPTIIGRVLIIHAKHDERMAQYHAKRNFQALVKAKLGNKPLKEKVDHLRNSSFILAPGTHDYFLHKNVPRNKDSDIIVWFSHLETQKKVMNFYFNRNLDDQQLFQIDNYIENENENENENENNTNLDLSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC28</accession>
    <name>A0A9Q0RC28_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precocious dissociation of sisters 5 isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC28"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="286" mass="34297" checksum="98B7CEB8F0784370" modified="2023-09-13" version="1">METIIINLFKTLSIFEIEEEIIEKEKMKKISKLINKELKKITEKEIPDSNQIKFIEALSFAKYIYKEIEDETKIEFLEIVLKMINLENIELLFKINSQIIVNCIESIELIPSETFNLIIYQFKDSIKKKDKLYEFYRQIISSSGKSFEQPIIQFLKNEITKLVTIEKEKEKQKKENKKKNKKKNGLQILPLLVHTLSTDDDNKRKQFTKLLSRLFTFRNCIFANSYSKLFHEFLGRFVDKNPEIRREMIDFSKNYILNSNLNIISNQNLNENENENVKFKFKFRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCA7</accession>
    <name>A0A9Q0RCA7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCA7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="126" mass="15217" checksum="77C156F238D63C1C" modified="2023-09-13" version="1">MIKIYRDLSKSIYQYRNEKKQLNEDLSFHSNLNSDSVVHFLCRVGAIYLVLVEERRKMEKTNGNILVSIQESWENFGSELTPEFLFKRLSWKKHHIIEKKRKIIIIIIMIIIIMMMMMRIFIIKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCL9</accession>
    <name>A0A9Q0RCL9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_08053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCL9"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="60"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5074698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="422" mass="47305" checksum="1A73581264D013FC" modified="2023-09-13" version="1">MLTIKNSLNPSKSSKIFANTISSLTSSFISKNLNHFQNKNNNNNKLNSLIKQIDKKLFSVNVQSKAPDFKATAVINEEFKDVSIKDLKGNHKWLILFFYPLDFTFVCPTEIIAFNDRKKEFDELDCSVSACSVDSHFSHLAWINTPRKQGGLGPMKIPIVSDITKDISKKYGVLLDSGVALRGLFIIDPNDVIRQITINDLSIGRSVDETLRLLKALQFYEKNGEVLNVIRTFSKKNSPKNSPKNSPKNSPKNSKDNSEDNSETEPILNEVSAEEYNEQKIRERDSKKYNLFKLAAISSSMIGVQVSYAVEFAFVTPMLSALGVKSSLVPVIWLAGPISGFIVQPLIGIYSDVCQSKWGRRRPYILAGSLITFLGVLPTMDLKKNGDIEICSYHYGCIKNKINLLKSGEHVEIWKNHFGKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD99</accession>
    <name>A0A9Q0RD99_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conditional loss-of-growth 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD99"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34958:SF1">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34958">
        <property type="entry name" value="CONDITIONAL LOSS-OF-GROWTH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="154" mass="18301" checksum="0989D193A5FD15FB" modified="2023-09-13" version="1">MGQHGFLRFFLCLCNFNNELIRLLKIWEKKIIHSLLYIFNHLPENEDFIEAKAACLVLLSQKCKKKLSDLKSIGGIEFFKDLLDHNQPLISFHASSFLTENFQIKFPDKFKSVMKMISKKAQQLNQIQLLKNPYFFIKETQEILERQKTKKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDC5</accession>
    <name>A0A9Q0RDC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cyclic amp response element-binding protein a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDC5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="201"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5076002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="49200" checksum="FCF902FAC9252042" modified="2023-09-13" version="1">MENGLPDLTDPFINFDQFDIESLDFSDLYNDNEIFGNENSNILESFPTILSKENFEETKNQKNSQFNDEQLENISLNNQEKINLDNQIDGFFTFNNKFEKKNEREISNIKSDELNKEMESKLISNTKTKTIKNSNSKINSNSKINSNSTLNSNSTSNSNSNSNSNSNSKINSNSTLNSISKKRKIDLENLLSKPTSELTEQEKIEVKKERNRRNAQKARARKKEYVQGLENEAQKLKEDKEKLESRLNKTNVENEKLKEEVQKLKKLLHFSTNQSNAQEKTTMIVDFLSNFGSIPILESNQKKKSKSKSKSKKSPNVSVLIITFAIGFFLHFCFSFFSSSSIPEQNFPNTKRSLFSEEDILFIQQEFRNKDSTFECDLSSGINCQNEFIENLNNIDYIYQRIQPNVEFSESKESKSYTLIRGNRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDE7</accession>
    <name>A0A9Q0RDE7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein derived from transposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDE7"/>
    <dbReference type="OrthoDB" id="6777587at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF57">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="189"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="432" mass="50084" checksum="D2B6AA50609BD8EF" modified="2023-09-13" version="1">MLEEEKIDINKRIRLISHFSEIRNISSVTEKAAKVYLIGQTEKEPISQRSICEFFGISLSALQRALTALKQGREVGRKGRPPVLSDEQKKELKEKIVHSAEKGKSLNINEVLEWINEHFFDEKPSIELDFMEKPHINSRGWVYNFANQNDIIIKLPQVLERARSQVSVDEFFYQPSVTLPKIENFHTTLVVCVNAAGKSLDPLVIIPMQSIVIEETPERNWFLLSVLSMHLLVGLHKKFSQNGRSKFSYLMFSSIKKQKKRRHCLFLMATIQGLVQEVIKDFMKNQIELFVLPAHSSHFLQPLDLSVFGTFKKYLRRRGKLSSNILSFLDVYDAFQSSATIKKIYSGFNKAGIYPFDPTKVLGNENIVLKPAGQEKLKKQRKRLDINGKILTSQEMLEKVEEYEKKKPKTKRKKRKKKNYKSKKTLFNKNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REU6</accession>
    <name>A0A9Q0REU6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REU6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="478"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="595" mass="69401" checksum="E118A163144B4894" modified="2023-09-13" version="1">MNEILFFGSNQSPKIIKNKPQRITKPIQFKFENENENENQIKQISTGYFSIIFLFKNGKAIEYLDENDLNQNPEKIQIEENIQKVSVGEQNEAILTLEGNVFAKGKDINPKNPNQFINISSLIEDKNDRIIEDIVSGRKSIYLLTSNQNVYGIGSNSYGQLGSQSIQKTKKPILMMKNVSKIFSGNISEHVFLLNSNQELFACGNNEWEQIGLGKSRKEDWKIKKLTKIQNIPKGKIIDIQCGYLHSIMLIENENQNPKRKLYSCGDCEYNGLGKNKDTYEFTEIKSSLFENDDNILDFSCGYEHTLILTSNSKLIGFGGNSHGELGTGDTNNQLIPIQIELPKLRFNEDISDYHLSCGYQNSFLYYSPSFSNLEEDLIKLFERKEFCNISFKTKNGEIIKAHKLILKYRLNQNQIEIEKLQEIISKKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQILEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFKNQNQYQYQFELKKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF34</accession>
    <name>A0A9Q0RF34_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF34"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="15446" checksum="172E9E4AB2741B28" modified="2023-09-13" version="1">MEIKDNWYENNHNTNEANIIEEFDSEDDNLSEIADNHNYHYLESAGKEQRLKVLTNFEFQPFLELFHKIEEVCESKGRRRRRKKLSKENQFLMSLTWLKHYPYWEKLGRDFGISETYNIYFIIFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF75</accession>
    <name>A0A9Q0RF75_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo-keto reductase family 1 member a1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF75"/>
    <dbReference type="OMA" id="WPQGFKV"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="131" mass="15265" checksum="2DFE3FEB886222AE" modified="2023-09-13" version="1">MEYVELNTKQKMPALGIGTYKSQKGEVGKAIKIALETGFRHIDCAYVYENEDEIGEILKETFDQGKIKREDVWITSKLYNIFHDPKDVQPACEKTIKDLQCGYLDLYLIHWPVAFEKERILNCSQEKMKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFF8</accession>
    <name>A0A9Q0RFF8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFF8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="270" mass="32386" checksum="97377BA0AB12D083" modified="2023-09-13" version="1">MMQSNELETRFSKYKMKDLESRMSFFKIAKSIKSLFEMAANCDSIQKFIRELTPQFQELSKKNDKSAYEQKLFELKKHCEIRNQYIENLKEHRIEIENVVNKFPNQHETSILQFNTIKSNIDYLYTEFEKTKNIEVMKSNFKIPIRKIKQEIDDKKKILVKIPEHLNYFEEWTQTKKAIVSLKNQKKELRRQQKQSINKLKQNFPEHFVPFFSSTFPRFQFNHSPKHSLESNQQNNSFSPNFSGTLTSRILHETKRAKFLQQVVQSKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFL9</accession>
    <name>A0A9Q0RFL9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFL9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="122" mass="14718" checksum="CD25E715272CE488" modified="2023-09-13" version="1">MKKLQENQKNLNSLIQKWSKLQLDSNSLISQQNNSVNNEKISQILLETLSKFESIFQKMKKQEKEQEKEIRIFLEIEYICEQYQNEFEMKELVVEQLINQPNKMKNSLLQIIWKTEPNLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFV5</accession>
    <name>A0A9Q0RFV5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFV5"/>
    <dbReference type="OMA" id="EARICQH"/>
    <dbReference type="OrthoDB" id="10677772at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="690" mass="81748" checksum="5D933F5CAFA431D5" modified="2023-09-13" version="1">MQTNSSPQSQKKHKKSKQKKRKKEIQQNQNQNQNQNQIQIQNQNQNQNQNQNQNQNQKQKKKKKKKKKKNQNQNQIQKKQRTSKKHQKTNQEKKENNQQISYLTHYKEKKVYQVELVDLNKNLDCPESIKLFELNNSIPILIRQHTHQILQKIQKDETLRSYMFKGPPGVGKSYILYHIANYCSKLKNWIVLYLPNTADLRNQESYQVAERIVWNLSENYRSLLEKYFFFSYNEEIWKISTPNKNQKLKMIQSCNDLLIKLINSQHRNIRILIAIDQWNILFRKQKESSKHILNVFKFIPKIKNGFFLAAVSASFSYWDQAYDDNAFDTIQTPLRIFNEVEFKTLVEWSKTNGFLPQDLPNTEIEKFTARIPKLIGFLFQAFRNYNLSYKKDWLTEAQELAENFYKRLILHVANKNEKNYSAINFISKIFLNSPIENLSNQWKSLGLFTQIENTSHYLPLCESIRKAFISAMNTNFVTFMTVLASEEKVKWRALELFVFNSFISSIGGSITITNRNLKGEQSVKTPKWSIQLDQQIYQQRSHTLNKLEKGTFLICYPDHPAIDCVAYSKNGNLFYIQISEESYSKHPKVDSLFEMEFKSTKETILEYYTRICGMELKPSKCQLKKEEETEKETEKETEKETERVIQLPPNQYYIYITTSPHYYKYSNTGYSNDPVILINSENISELDPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGU8</accession>
    <name>A0A9Q0RGU8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGU8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="107" mass="12900" checksum="5150AADBD52A6836" modified="2023-09-13" version="1">MKMKNGKDFIIISEDKEIKVHKLILQARSELFRGMFVSVNDNSNRVNDYSDKSNESLSYFIKFLYYDEIDYGMKESIYDDLEELQDFYQLNERSFLRDHIDNLKSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGY1</accession>
    <name>A0A9Q0RGY1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGY1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="106" mass="12819" checksum="D5C2E14EC80D2AFE" modified="2023-09-13" version="1">MSFNSQLNENINEILLKLKDETRRWKNVCEKMREKFKFQAQNQSQLETKQNEEINDLKIKINEAREKRDSLHKQLDNQKQINLSKKGNEIEELTNKGRELELQELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH74</accession>
    <name>A0A9Q0RH74_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000030">
        <property type="protein sequence ID" value="KAJ5079513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH74"/>
    <dbReference type="OrthoDB" id="2306559at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF42">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040385736" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="171" mass="18959" checksum="DA425F2BE3E9B044" modified="2023-09-13" version="1">MISVLLELLLGRLRYFIAVVPPQPNSPPDLSSESSSKGSSFPAIRTKPVPFAVGSLEDDEAFGYLKRVIVTPAVHTSLLKFLHINIQCTEQNSHYSQSFSRSYGSNLPTSLTYLKLTGQRLLTLGDLIILPNFFPFLQLICFNAKLLETTNPDSITVHLEPFSTSAFKILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHL8</accession>
    <name>A0A9Q0RHL8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1518"/>
            <end position="1531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1531" mass="182685" checksum="258820D9A6752BF4" modified="2023-09-13" version="1">MAEWSKAIVSGTVPFRTWVRIPLLFSLYEFHFFTKETLPFFILNLPERNFLFSTLQEIFILLIDIYITNLPINSLTSLTGLKIIFQDDSYKFEDVDSFLSNKDYRNLRKSYSLRNKQIPDLKIMNLSFSKKNIYSSTIHEFAQEKFNGKRKNKRFSWLETRNSKHFLLKVFNIQYFGEYYGFSQFLKLLQQYFAKFQLKKIQFALSFLDLEKFVTIFQEIAKHYPKDQPQTLLIQKYNEIFNYYIQIINPDSILFALYNLNEIIKILSTCSNQPKNDSKNINNNFLTSMFRKNFTKLFHLLEKTDTFLHEEISKYLLKILPILIDHSKILTILENLWKYFFRIFRNPDQKRTKKGLKHCLYFIANHGGKNVVEMFINLFHQTEKQNIYSPPESLQKIWIKITLQILRNENSTLILSEYKKKLLDYESFTGDFQDLPLFGLSLIWDPIHFQFKINSNLPSINLFHSAILHDKSNFFYHFFMFKCLKNIESKQFPVSSLKLLNEMILLKSHYSEKKSMVAQPLKLNKKYQLYSHLLQNFEDFSTDDQISEIEIHKNLSEWIQIINHLLLKFDVNFQFIQELWKIIMNFKGKNQEELIKWIQSLVGYEKNTQDDYESYHKTPLEYYSKQNIPNTIFTSKKFLAFFLTDILNLVDEKMITNQFFKLFKKVFLLVNQNENKMISSNQFHILQYSDPIIDSIIKISTNQLIGLAKIQAIIEKTENEEISQNAILFYSQISAKMNSQDKVSILQDILLKLPHKGNIVSEYFSNFHFVKRNIQLLSQIIIESDKIESQNFPYEELKAHEKRISKFRPIKILVKKPHEFSFLALDHLTISTIAQIIAFESRRKLNSFEIYQKDPIPSNQNLNRIDSLANEEDGLVTFFILDQANNSDSIKNSNNINNSNNIKNSNNISNLNNIKNLDDIKNLNDSKQNQQKSFSFQKFCAVGPQMCRMKEDSFEMKRFTARYLSFPKNFEIFFNLLDYPEVAEEVFLLIQQLPSFYSIFKKIDYSTDVPLFNPNRFYQNENENENKNQINSETQGDALKDSFTIPVLNDFFKKKSNIYQLIYIIQAINICSFQYKKDGNIFENNHLRINSISYNPNVIEKINAYIFHNESWITNNFNNEKNNSNKMIQFMKLFSHYSQNITQTKIQIYQLEKMIYFFDLILRQLIFVLNPFLIFQEIFKTISTSQTKFFFDLNEIHPFIQSLMELIIKLLDFYPEMHNSKNRTFNSFYESIKKMFLFFFSHNDKLDYWQDMFLNISQDFKADERSESNDFTKKYSKNPEYKPTNIILNAILTIGSEKIAEILLSILLYFEYFFYKHEFQKTLFIQLSDFMQKIENGDQKISTERYYKIFFQLFTLQPSSLSKELIQQKKKYSDHFIGIPFLNRLAKNQVFNENISFNILFLKIVFILLRFEKSISLNNLHSIINFETFQLLIQIMIQNHNLNLSFSNQIKIVSLEIILSRQEFQNQFLDRISETFDPKFIISKQQNEKQNEIQIQNENQNENENQNQNENENENENQNENQNQNQNQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHW0</accession>
    <name>A0A9Q0RHW0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000005">
        <property type="protein sequence ID" value="KAJ5080652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHW0"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="346"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="421"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="521"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="626" mass="73324" checksum="AE256F044A039BAA" modified="2023-09-13" version="1">MNEIIFFGRNEYPILFKNESFRITKPIQFKFENENENENEKQNEKQNEKENENENENENENENENENEKQIKQISSTYFSTIFLFKNGKAIEYSDEEYSNQNPSKIQIENIQKVTVGYRNEAILTKEGNVFAKGKDINPKNPKEFINISSLIEDTNDRIIQDIVSGDSAIYLLTSNQNAYGISSNEYGQLGFDSKTLKKTKKPILMMKNVSKIFSGNSSNHIFLLNSNQELFGCGYNEFGSLGLGESRKERKIQKLTKIQNIPKGKIIDIQCGRWHSIMLIENENENENPKRKLYSCGSSGLNGIDKYGQNTYEFTEIKSSLFENDDNIIDFSVGFLHNLILTSNSKLFSFGNNDYGQLGTGNTNDQLIPTQIELPKLRFNENISNYHVSCGFNKSFLYYSPFLSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQNQNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIINEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5Q8</accession>
    <name>A0A9Q0L5Q8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5Q8"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="205"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="275" mass="32414" checksum="AE2878B7B786281E" modified="2023-09-13" version="1">MSNLNIEEISNNFLKVFFHVLEVETSQLIKFYQENSTLSFGIESENYTIYEGKENIQKFIENSISKKTNIYDAISYLIDENKILIFICGIAEDLKKLKHKFTRTFILCPLETQDGYFIQNDIIKKLKNFGTISESNLKRNIEKLKSKQNSKTFEEIILESQKLLEKKEKEQKKLDQKKEKERSKFKPKYSYNPIDEYDHEVIPENSIYVSNLRLATKDYQLGIAFTNFGNVVYAESRSGKSFGFVEFDSKEAVERVLKEKEIIFDGRVLKIRKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5W4</accession>
    <name>A0A9Q0L5W4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cerebellar degeneration-related antigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5W4"/>
    <dbReference type="OrthoDB" id="5591912at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="685" mass="80583" checksum="3A2318FD3AE666AB" modified="2023-09-13" version="1">MSNSKETQIADLISQKTHEKFNFKLKDKQFWKILCLLIYRFDPQKQKKLPKQTMEQNKETFFRFCKKIEAPKNLLNYQKKTDLIPLLQYILSNQSTKQKRTLKEFSVRILDSDLAKIDTGQLKIQNDKVTILTLNADYSNQVSKIQVTKHPHDSKVLKFSFGNSIQIVSFNTESERDSFLSELSKMKDGSKKDKMENDLDFNFQTDLEMKNIQEPIYPIKFKVNIVDNDLKTLSAAILVLDEKEFQVQTKDQIKRSRYNKKLEIFYDPKTMTLFKINLKNNKYFVLFPVSSQAKAFLYIYNKARFQPYSQKDEMNINQNSNMQFNENTTTSTSSFEQSKSQKQNKKEFKTDDEFKTDNEFKTDNEFKTDNEFKTDTEFKTDNEFKTDNEFKTDTEFHSEVEMKSEDDFKTDTDFHSEIEMKSSDENTPKNYPKSYIQQKYQENKTDSEFETDNELAYGNQNLPKFQTFEFIVDLVDKHLIKIEQAKIIIRDQEIIFKPGNSSPKTSHISNVLIGSHPRHPTIFTIKFKDSNSFFFAVESENIAFKFMQTVQERQQKSNPNQNSIQNPNQNENQNLNQIQNQNQNQNQIQIQIQKNPSFNAEVIDKSLNKVSDVIMTFEDSMFQFKTDTETLFSAYDSSLQVFVHAQLENVLRISCASKIFRISFSSPEERNEFLSTFQQKTGNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L632</accession>
    <name>A0A9Q0L632_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tobamovirus multiplication protein 1-like isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_13371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L632"/>
    <dbReference type="OMA" id="ILIMWNL"/>
    <dbReference type="OrthoDB" id="19353at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="7">
        <location>
            <begin position="10"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="267" mass="31241" checksum="AB8F4D3079AE3CFB" modified="2023-09-13" version="1">MHVAQFTVEITFYSILFVFLLIQIIRLIFYRDLQLFYNLQLRFHVLSIIFAIARIIATGLETSFEKYKLSVFIVKRIAYLSFFTSFTLLLFFWSKIAKGLQHNDKTPNSIKIPLIVANFVFYLFTIISIIIFSTSVADPDYSNSFYQVNSVIVAAAFFVVSISFMVYGIVLLRKFKKLPDLVLSRKKYMTKAFFLTLFVSICFLLKVAMFLYHPISEKDMNSWLFLFLGYFIPELIPAYIQAYGMRPKTQKNAKTTEMRLLDETTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6C1</accession>
    <name>A0A9Q0L6C1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase superfamily with octicosapeptide/phox/bem1p domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6C1"/>
    <dbReference type="OMA" id="FRCVHEC"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="516" mass="61967" checksum="8371902AEB1A7A2B" modified="2023-09-13" version="1">MEIFWDLETCDLFPNVKIVDLINSIYIFALEYGNVNKIHAYFNQKEFFKNPIFEFQKIRDDFSKIGIEISLILEEFFANICELVLNHEFDKAYLSDQIQLKIILITGNQIILFKLLEFLEKQNVSVILICPLNNDWFQKNYKKILGFRCVHECFNWPPIEFPLFIQPKKYFDEIHFKIENLNENQNQNLNQNQNQNLNQNLNQNLNENQNQNQNQNKNQNQNQNQNQNQNQNQNQNENQNKNKNKNQNQNQNQNQNQNQNQRKNLNQNQNINQNQNQNINQNQNQNQNQNQIETQNLNLNQNQNQNQNLNLNLNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNINLIQNQNQNQNQNQNQNQNQNQNINQNQNQNENQTEIKIENENNIPFQFYNLFQKSREKEYSFQFSKSNTENEKTPKIPYQFKKLMKILLAFQTDKITFNDLKKVFSIYYPFLSIELNRFLLLAEEQGLVILGLSQAHLPEKKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6Z2</accession>
    <name>A0A9Q0L6Z2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sand protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6Z2"/>
    <dbReference type="OMA" id="QQPFNAK"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="2">
        <location>
            <begin position="197"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="3">
        <location>
            <begin position="357"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="4">
        <location>
            <begin position="526"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="639" mass="74037" checksum="5C80EC50E4620A17" modified="2023-09-13" version="1">MSDNKENKENNNENTTTGVTKSAPGIGLEAVAFRMPNQDPSAENEQDTNVYEPDDPYGAPQDDNTKSITSSELDDREKMSEIKDNEIDSQNQDDDLEINQNQIKNQNLNENQNNENQIEDQNNENQIENQNQNQNQNENRNQNQNENQNENENDSFENPKIKIEKHDDNQFNTKFQRLYAKYSNEDTSSPGWAKHKKHFFIISSSGKPIYTRYGDDSKLSGFMCVPQALISFVSDFGDTIKWVHADDHKIVFVIKGPIYLVCVSKTGEPVSQLTKQLNFLYGQIISILTNRAIEILKKKPHYDLRILLAGTEKFLDSVIYEMNNNFTFIVNGVPCLKIDPQIRKKVGQILFEQKIQHLVFSILLAKKQLVHIAVLKKIISPTDMFLLINFAQNESFKTSQSWTPICLPHYNNSAHLYAYINYLDHDNDICLLLMSRDMRAFEAVQSANDNIVKQLTENKVLDEVRNAVQESEKFTMSDVKIDGLILFTKLKLTHQTQLTENKVLDEVRNAVQESEKFTMSDVKIDGLLHFIYKINLTHQTVCPKVSPPYTIPKERKRLFRLYEVVRTRLASFKSSITNKTYFRVSDSETVLGRLEPDYELYTVFSPLISKSETLKKCEDLLEWIKNQEDQFFIQHFFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7E9</accession>
    <name>A0A9Q0L7E9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ITEQMLM"/>
    <dbReference type="OrthoDB" id="19599at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="9">
        <location>
            <begin position="3763"/>
            <end position="3834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4180"/>
            <end position="4208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="3968"/>
            <end position="3998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="4188"/>
            <end position="4197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="4198"/>
            <end position="4208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5067471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="4503" mass="531724" checksum="2B31845B96CB1009" modified="2023-09-13" version="1">[encoded data, 4503 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7F8</accession>
    <name>A0A9Q0L7F8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7F8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="632" mass="73503" checksum="19B49952D56A37F9" modified="2023-09-13" version="1">MNEILFFGSNQYPKIFQNEEDRIIKPTQFQFSNEIGNKYKIKQISTSYFSTIFLFENGIAIEYFNDEYNPNQNASIIEIENIQKVTVGFENEAILTIEGNVFAKGEDITSRNSRQFINISSLIEDTNDRIIQDIASGYNSIYLLTSNQKVYGIGSNGNGQLGFDSKTLEKTEKPILMMENVSKIFSGISSSSVFLLNSNQELFSCGFNFHGQLGLGKTRKQAKIYKLSKVLNIPKGKIIDIQCGVNHSIMLIENENENESPKRKLYSCGNYQYNGLGRSEQYVYDFTEIKSSLFENDNILDFSVGTDHTLILTFKNKLIGFGNNSSGQLATENTINDQLIPFQIEFPKLRFNEEISNYHISCGASKSFLYYSPFFSAFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLKPNQINQLEEILLQKSIKESNQIFEMIYSNRSKINPKLYLDIKEIINSNEKLEETMKRIYLNENEKDFIIERKGKQIKFPKLILIMRSELYRGMFLSVNEDTSNQVTDSSGISNKSFQIFEYWIYSNQIKKGIQITQEIIGDIEGGIDYFQLNQTNPNLFDLLMKEYNIQEKEKEKEKEKEKEKEKEQNQNQNEKRKEKKKKKEKEKGKKCFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7U7</accession>
    <name>A0A9Q0L7U7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar atpase assembly integral membrane protein vma21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000123">
        <property type="protein sequence ID" value="KAJ5067952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7U7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="104" mass="12256" checksum="0709D71365D86EB0" modified="2023-09-13" version="1">MKNSKDKTTFFHELMKSKNNSVFRKLLFFMILLLIIPVLVYYSTNYFLERNPTIKIKHSLVSAITSFLSVILILGIYVIVAFSENIEEIEDEKIIRKKPKEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7Z0</accession>
    <name>A0A9Q0L7Z0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7Z0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="264"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="486"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="591" mass="68502" checksum="452F90BAAC88C911" modified="2023-09-13" version="1">MNEILFFGLNQYPKLFENEPDSITKPIQFKFENENENENENQIKQISTTKLSLMILFKNGKAIKYSNGKDSKQKLEKIQIENIQKISTGKNVEVILTIEGNVFAKGYDINQENPNEFINISSLIEDTNDRIIQDVVCGESSIYLLTSNQNAYGIGSNQDAQLGFDSNTLENTQKPILMMKNVSKIFSGNESTSVFLLNSNQELFGCGYNFSGSLGLGKSIEETKINKLTKIQNIPKGKIIDIQSGWYHSIMLIENENENENPKRKLYSCGYSSYNGLGKNENTNEFTEIKSYLFENDDNILDFSVGYIHTLILTSKGKLISFGANYYGELGTGNTNIQYSPIQIELPKLRFNENISNYHISCGNSKSFLYYSPLSFSNLEEDLIKLFKRKEFCNISFKTENGEIIEAHKLILKYRLNQNENENQIEKLQEIISRKSIKESNQIFEMIYSNNSKINTKLYSEIKEIINSNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDDIEITQEIINEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L845</accession>
    <name>A0A9Q0L845_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1369" mass="161839" checksum="325D0EF0F3DBB499" modified="2023-09-13" version="1">MIYLVNFIKSLKEILKIETVLKKWLKDYLNKIVLLLSFNILVFIFFFTIKKTNFGFYHQFFIFLSTRFLIPIIFILWELTSFKIENFHLPKNIKIRRKTLSISKNPLFYIFFFFFLISFLFILVLLSISSQYLITSIFPSQSFFANEFNSKELIKGYGIFIIVILISLIYYSEEYILIKNIYQPLEKLELFDLISKKELSKKGFQAPLAILLTALISSIYQIPFIYSQMGGIYGNRINYFFKWIGMEFFIQMLSTKIYSTTFNFGFAALTRNINEDGKRNQIQIQVQIEKEKEIEIEKEIENENEIQNEIDNDSNTRKRNQNNENNNLENSDSNPNSNNKTISFSFSNKILNEKFIVIFTLISITLFWILIFKTNQIKPEIEIDIWEKPDDKEIGGCYSKNIMKIENDKLFFINCEGFANFTIIEDYPEYKETSYNYSNPFDLEHISIENRIIGECRIPFIPGYQKEVITYIHPKIFERAISRNEKRCIINQINQENENENLNKYPNCIPHKSIQNKKIEEYEIKPNIVFLLFDAASTPIYEKSLTKTISTIEELENKKKKIKSFSFPGYRIVGLNSYVNQHPMYCGKKQEIMESPYSDSFLWNIFTKKGYFTTFIDQLCSGYYQWVWRVEPEMSLDACPFDYRFYRHFCGPDWDAFENNHPHCLYGNYGYQYNLNATYDLLNNPKYIEIPKFIISNFYESHEPSQKVFKTVDKDVSSFLKDIYSKSIGDYTIIVILSDHGPHYGYYKQFYHKYPLFNIIFPNKFFEKFPNLKTILKRNEHNIFSAYDIYSSFVHLINNFESYDKKTTHQSLFDPEMIPNRSCDEVCLLENFNEEDHNYYSIEYLNEKYLPDSKQNPSKIQIEENIQKVTVGSLNEAILTIEGNVNAKGEDISSENPNEFINISSLIEDTNDRVIQDIVSGAYSIYLLTSNQNVYGIGSNHYGELGFDSEALEKTEKPILMMKNVSKIFSGIDSYSVFLLNSNHELFCCGYNGHGRLGLGESRKEETKIQKLTKIQNIPKGKIIDIQCGFYYSIMLIEQEDENPKRKLYSCGRYRFNGLGKNKNTYEFTEIKLFLFENDNILDFSCGGYHTLILTSKGKLIGFGNNNFAQLGHQSTKFNPIPTQFELPKLRFNENISNYHISCGMFKSFLYYSPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNQNEIEIEKLQKIISNKSIKESIQIFEMIYSNNSNINPKLYYEIKEIINPNERIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDELKIGIDYFQLNQTNPNLFDLLINKFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8P6</accession>
    <name>A0A9Q0L8P6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8P6"/>
    <dbReference type="OrthoDB" id="298084at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="44"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="219" mass="25617" checksum="B242E0EB082447B2" modified="2023-09-13" version="1">MKSLTELKKEKENENENQEENQIQNQNQIQNENENKIEFKDSEIINDNRYVQKLQEWINDNDFFSKMKKGFSAKRDGFNCENWHKAVDNKGKTLVVIKTKQNFIFGGFTKVGWKKNKSKSNQKDTQFYDGYINDSDAFIFSLRNNKGDRQPEKFSIKKKEAKNAIYYGLKNGPVFGGGNDIKIKSNLKSGKLNFGYTFHLPKRYNVGKQSSSELFSWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8P8</accession>
    <name>A0A9Q0L8P8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription elongation factor a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF93">
        <property type="entry name" value="RESTIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1706"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="592"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1595"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1609"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1633"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1706"/>
            <end position="1723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1870" mass="219944" checksum="A4D403C55F898724" modified="2023-09-13" version="1">MNDFNQNENLINDLFSWVSRIIKKEFQPKMQIRSIINNLNLLLTKLNPIIEEAKKKSLPTVAPLNIKYLMTQCKKYGIEEKLLFEPNEINLDNKLDKIVPLIQKIKELATNREKLLHEPLLSPRARTIQREDYEWTSGEEDNSQITEKEDSEITEHQLLYRRDAKHIMQTIQGYFANGIALFNVAVIDKDSEMNLESVLKLKQNSYEIIIEMQQPIRQRYLPKHERNIETENLPTQSLLKIHLTAKHYLKLAVKTTDDQFLIAITFRMFQHYSGFTTTDIISGDILGIENEVNALVYRLVKKNRAVFQIAFRQNSNDAYSLVNLIVEKGAARVFDQDANPLLDIQLTHSIRIRKHDLSLLEIFIKEKNQKIEFQCDFFSQRELLLKCFTNFQIETNTLLDNIPLIVQNWADNKQISLQKILNEEKQKSNFCQVYNDFSKIFTYSQFTKEGEALVLQKNQNIPFQDNVTFNAPIIQCSNIQQKRVISDRMEKLMNKKSAKFKIKIKGRQKYRGMIVLGRKGLWIAAGASRNEQEKHLIIPYSGNCHFYLNSMNLKQFVLHFRDDSFLIVMKSSVERDIFINIYLMFAKKQPVKKLLELANLNLKEELENVKKSNKKKDKKKDKKNELTNSQNIKKTDLLFVLTSAYSAFIPIESTLHPLTLKNFSKFHSPEATIYKCRVYNSFSINVGEVEISLHFSHFVLRYDKITVSRRYSPFSRISFANDHTSRGCFYIDESIFIDIEFMDNSSRRGFAFDFESKRKNSSWFLYFYFKNELNVEIFKCKASTIYGNFSAEVTLARSCFSIKYFFLDPSVQTPQSHSLNLPDHNTVTSQYTSLMTAIIFEKNPLIVYLKLGHSFFISLLFADNQQALDFRKSFIAKKDNHLMFVSREALFRKNISIARNRFEAVVSGSSRLSGRFQIILSQNILLIITHSITLAQFPLQNHKHENISRDPKQIKIKFRIEKINQNFIFTFDSEKMKLQFIDSLSKFDVQKHFKNLIQFNINESDLYFIAKIVTKYFITKCKLCLNFKKRMLHLKIPGLLSEKNLPVAEINPLVDLSRPLQVDIVTPSENFKLIFPTCHERVNFVRKIFKFKSLAKEEIKPQEKENPELSSFSTRSKEYDLQSTFTSFTRGSPDIAIQKSPIPQNLEAQQIPDPQLKTHRFACSLLDPKNMTIINAGSLLEIQGTFITISTGKKKNQFHLDSNFSVRMSPVKSDKTIILYQDTIEYCLSFVNKNIKKKVVDLLSQISKLLLNQEYSARINYNGHDKISIIRVTNNFMLIKFDLKKFKIPYQKISFQIHDQKIISIRIECENENLFNTILSFIIDRKTRFLHYSLSLIPDKKIFQFTPFKIHLPSLGLTRELPAQFLVYVYNPLFKNKTQKANLEVNSSKFSLMFNDHPNSTYESDSSSSISLFFDSKSQRVCKISILDDFQIEFVLFLKDEEERNELARILSPLIKENLEETTNEIQNEIETQIKNEIKNEIKNEIKNETKNEIKNETKNETKNEIKNEIKNEIKNEIKNEIKNETKNETKNETKNEIKNEIKNEIKNEIKNEIKNETKNETPNKNQIKNETKKSNQKSNQKSNKKSNQKSNQKSNKKSNHKSNHKSNQKSNQKSNQKSNQKSNQKSNHKSNQKSNQKSNQKSNQNQIKNEAQEEKNLNQIDLNEDDFIEYNIKEEHFIKEDFKLNQVNLNEEDFIEEHFIEENFRREENKSKEENKSREEKQNQLNQENQLNQLNQENQLNQLNQENQENQLNQEIESITIIKINEDTSKISQIFFKEYHIHIVNEDETLKFLIPLTKIFFDQSTLIFQMKNKNELIKFKCKKEEDITSFYNKFMQKKGNFFQTKMIQSFHPQIQDKLNIYYLVWKQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAI9</accession>
    <name>A0A9Q0LAI9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">pyruvate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="10">1.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pyruvate:NADP(+) oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_02056</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>pyruvate + NADP(+) + CoA = acetyl-CoA + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17425"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.51"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.51" evidence="10"/>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAI9"/>
    <dbReference type="OMA" id="IVVMANE"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050243">
        <property type="term" value="F:pyruvate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03377">
        <property type="entry name" value="TPP_PFOR_PNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000022">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000012">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000041">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.920.10:FF:000001">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="entry name" value="Pyruvate-flavodoxin oxidoreductase, EKR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050722">
        <property type="entry name" value="Pyruvate:ferred/Flavod_OxRd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154:SF0">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="762"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="716"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="719"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="777"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="835"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="863"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1095"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5069486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1203" mass="133648" checksum="035A46D63E627804" modified="2023-09-13" version="1">MYSLVSKNLPKSIERSKKELLRQFIRKLANKTKLSHPMDGNTAAAHIAYGLSDQAFIYPITPSSPMGELADMWSAQGKKNAFGRVVDVTEMQAEGGAAGALHGSLSAGGLSTTFTASQGLLLMLPNMFKISGELLPTVFHVAARAVAGQALSIFGDHSDVMACRTSGFAFLSSGSVQEIMDLAIVAHIASMESSIPFCHFFEGFRLSHEINTIETVPYDQLHQLIDKDLIEKIRKRGLNPEFPHMRGTSQGPDVYFQLVESANKYYDNLAEKVQDAMNRVAKITGRQYNLFDYVGAKDAERVIVVMGSGASPIEEVIAKFGEKEKIGLIKCRLYRPFSKKHLLEALPKNVKRICVLDRTKEPGALGEPLYLDVSAAVKELGIEVYGGRYGLGSKDFTPAMALSVYENLNQLKPMNNFSVGIEDDVTFKSLKVGEEIDTVPEGTQQCMFWGMGSDGTVGANKNAIKIIADNTPLYGQGYFYYSAHKSGGLSVSHLRFGPNKIDSPYLIQNADYIACHNTAYIHKYDILDKAKKGSIFVLNSPWNSLEELDKQLPGSMKRKIAEKNLKFYNIDANSIANQVGLSGRINMIMQAVFFHLSGVLPSEKAIKLLKEAIVKEYGKKGQDIVNMNHKGVDHSISNIHEIKYPKEWTKAVLEEKEDMKDLPDFIRDVMKPMARLDGDKISISKLPEGGFVPLGTSQYDKRGIAEKVPKWDPTNCTQCNFCSFVCPHAVIRPFLLNAEEKSKSPNNFQTVKANGVKEDLQFRIQVSPLDCTGCGLCANTCPEHCLTMTPLLEMQNQIPNWNFAMKLPVRDDLFKRESIKGSQFQKPLLEFSGACGGCGETPYVKLITQLFGEQMVVANATGCSSIWGGSYPNCPYTTNKEGHGPAWGNSLFEDNAEYGLGMAKAIQNQRNGLAELVEKAIKSNADPELNSLFKEWIENFNELRKSKELSGKIKEKLSKNFYKNELLGEIYKKRDLFSKRSQWIIGGDGWAYDIGYGGLDHVIASGEDVNVLVLDTEVYSNTGGQSSKSTPRSGVAKFAAKGKNTRKKDLGLMATTYGNVYVASVSLSNMKHLLKCLVEAENWKGPSLIIAYAPCIEHGIRAGMITQLKEQELAVKTGYWSLFHFDPKLEQSGKNPFVLDSRKPSGNLLELLKHETRFASLMSTFPEEAKIKHKQLQDDILKRYETYVRLSQKFEAKKNKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB30</accession>
    <name>A0A9Q0LB30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB30"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="172"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="805" mass="92980" checksum="43764D660C6A16AE" modified="2023-09-13" version="1">MSEVPHLYIRLLEVGNLNFSQAQDSLINCSFTFEKRILKSSKREYSKQIKWEKEEFLFLVHHQDSFIGLTLNYHNIKKEIPFGKLKIPLSTLSDEKSVSQIFSVESIEKKDKKPDIVGKIHLQLHYSYSTVSLYDTKKEHNWRTKFPEVIDLLCSNNYELLNAFCDVVHSGAADKTALTLVHVLMGFGKALDFIKFTINRETNHTNNPQQLFRTNSIATKMMTIYSKLIGEDFLVSCLKKPIGELFKLKTEIKIRDKNEKEKSLEILGHFLKLFFNSIFKKILKCPIEIQEICHQLNTSVQKKFSGYGLIAVSGFLFLRFFSPAITSLDSDTIISEAPTPLVRKNAVIIAKVIQKIANHLEPGNLERDLDPLNDLGKELIEKLDTYLEQISRFSEFKKSNVNQNFLSVDFHYLLDLHNLLKDHQFQIDAVLTPPVESEEDNQTSSLLSFLTSKDPATILIIQLNEFGNPPEPSFKKSHTVSGKIIQKRKAIKINEDTDVIKEQEEDANILNKNSIFAQKPRDPNIVSETLLESIYEIYQNHELDDLDLLSALNTENFHFSMFYSAREWDKMKNSKAYQDFVLSSIGEINSLDVSTLDQDQRLAFWINIYNTLFIHGCIENGGPPLTHFQLKQFKSEFKYIIGDAVYSCDDIMEGVLRGNPKSFLGGSYFKSQNDPRYHVTLQEFSPLVHFAITDLRDFSPEVKIYHAETIQKEMMESTRDFLENSIKIENKKIILPTLFKFFRKDFGKTESSIIEFICVTLLFSKSSFLEQVKLLKESNFVIEFKNPKKDQEILLNNQEKTKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBA8</accession>
    <name>A0A9Q0LBA8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mediator of RNA polymerase ii transcription subunit 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBA8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="186" mass="22342" checksum="80B621FB47E539F2" modified="2023-09-13" version="1">MLKQPAFSFSYLAGSSKYYQKKCISLFNHLFTFNHKNYIHSIKELKIKNQNQNQNQNQNQIFQFLFEKSLKKSSISHQQIQVLSQKLKKTQLRSLYYQKILFPSLVDRSIFFIKIYRLPLSQNRYLFTNKFISFFEIEGIGRRKRGKKEKRKKENKENKSKKHKSKSKSKSKSKSKSKSKKEKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBQ9</accession>
    <name>A0A9Q0LBQ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Straightjacket isoform c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBQ9"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="96"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="460" mass="52571" checksum="E96CFFFB976AC082" modified="2023-09-13" version="1">MSDGEIMMGAQDIGNFRAQIEQTKTIDTNSITYKGIFSEYFFYCGKQEEKELLTTDTSTAITMNPLTKEKEYFLSFGLKSKYDGEGIKKYGRPSLNLMIILDISGSMSDSFRTDNDLNENEKIASKLEIAKRAIIGLLSHLNDSDNFGMILFDSVAEIFENFGNWKEKNKEDILERMKSLKPRGGTNMEKGLSKGAKIIQKFIEENQEDKTRESRIMFLTDAQPNLGRGTGTLIDLIEKYSEKRLFITFIGVGLDFNTELMEILSKIKGTNYFSVQSSSEFLRKMDNDFDYIVTPIVYDLIVKVEGAKILNIYGIPNSEDAKNTIVTKILTIMPSNYNEKNECKGSCFLLKMDPSVSDGIPLNISLSFKDKFGNPFDQKHSIIFPNFNEKEENIQIFEDSRVRKAVLLIRFVDLMKNLDLNKDESKEKARKFSEHLISEMNIIGDEQLKKENDLIQILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBW5</accession>
    <name>A0A9Q0LBW5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBW5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="195" mass="22851" checksum="DBE53A685511AF89" modified="2023-09-13" version="1">MFIAILFIFFTILPFFLLLRQSIKHFPLLIILSSFFFSLWITVTGEEFSYLQFIRILQNSDIWFNFKQHLSNCFIFHSKIKIPASFLQGSICTSTYFLSDLVDICEQNRVFREFGLKDNISFSLSVVVFLIGILLYLTNQFRMGLFSLLFSQILIFRFVNENKQTIHFGIGFYLILLGSLLGLIRFSVWKNAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBX1</accession>
    <name>A0A9Q0LBX1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fam11a b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBX1"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="480" mass="56620" checksum="67DE3E5E5750F97A" modified="2023-09-13" version="1">MKNFQLINYKSKPVVKIEREHLYSLQITESSNFGESLKTPPLEENLILEMLPEEILLYIFQYLSPGELIKVGSTCTTLNELSEDKNTWRNISYNYNQFFLFNKVEVPKRNEIYEENRIPICGIIKESQLITYNINSKQKKPEKTNSGLTSLFKRRDQDQDQNQNQFVNEIILFDRKKTEKKLIEYIEKIPNPKEELISKGKLIYNGIKERKQQIEKNLKRKEENAKKWKKIARIDDFLFGNLIFLGIGFVAFIITLNVYIEKKLSSNTIYIFIPLLLPLLVYIVLIFYSLKLDRETTFLVYVLMITVLFIQLLLIGLRADSTIKGSWLLIFLPFFILIGITIIGIIIWICNDPDSIIATLLMIFIMLFLFLMFLGLRLDGKIKWNYGIVFIPLFFINLFPFFMSLSLFCLHPRTYACTIFFSNILIFLFISLPISLIETFIVLFLEVSKFNHITYAFVPLYAIFSCFLCWLFYFIHDEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBX2</accession>
    <name>A0A9Q0LBX2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_02696</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBX2"/>
    <dbReference type="OMA" id="AKFRQGC"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000592">
        <property type="entry name" value="CAMK family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="12">
        <location>
            <begin position="693"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="583"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5068753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="743" mass="86569" checksum="77DB36E9700DD3AD" modified="2023-09-13" version="1">METENIQRIIGRYIVGKTIGEGSFGKVRLSTNIETGEKVAIKEIDKSKVLLEKGAKEKLEREIKILQMIDHPNVVRLFEVFEDEQFLYLVMEYAETGELFDFIVTHGRISEDLARDFFRQIIAGVDYCHKLNIVHRDIKPENLLLNAEMKVIIIDFGLANFTHLGELLTTSCGSLSYSAPELILGKEYIGPKVDIWSLGVVLYAILCGFLPFQGPTVRDLCQRIVQGSFQVPSFISLEATDLLYKIIDKNPDSRYTIEQIKVHPWFTKGTKKQDNLDNEQDFFANISIDDEVLMEMKQLNFDSEEIRELIKNKIHNSTTEAYRVFFHNKQKRMDAQMKQSAQTRQWNRNVNFPVQRPNFFGIPNQQQFPSFKPPQYQFPFQNTFQYPSQKMYYQGMNPSQIPFPQQGARAQEHSVQSQEMEFETEDQNEKKEIPQNNDNKRYFLNPSIFGPPLGYFTKPSVFQDPPFQFFNAQNTQQGINTNRININNPNIQSNGNIFPQQNIKPQFPIPNYAQRKFHSNIFPQQIQPQSHFHPYQNPQFPPYTLPPFSQPNTSMETIYSQSPVSKQRANTMSTNEMIEISSKIQTQKQENSMDHEPSPQNEQQNPNIFPQKNPKITDETKRDRAITFEPHDIPKISIELNELKKNDNQQTREARGAFDASTTSSRSPKSILKRCKRMLKRQNVIFKEKGFVLKCTKNEIKFELEIVRVQNLRKLNMIKFKRIIGDIWEFQKLCALLVQDLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC88</accession>
    <name>A0A9Q0LC88_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="AKWEVES"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1782"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="1914"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069694.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
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    </evidence>
    <sequence length="1925" mass="228256" checksum="BBBF8E7F437E53D3" modified="2023-09-13" version="1">MKIKRKLKNLKKKFNNKNQKKKLLKLKNQKKFNNKINKNPKKKLEEKKRIKEEKKKEAERIKEEKRLEAERIKEQKRLEEEEKKKEAERIKEQKRLEAERIKEQKRLEEEEKKKEAERIKEEKKKEAERIKEQKRLEAERIKEEKRLEAERIKEEKKKEAERIKEEKRLEAERKKAEKQMKKQKSKDEKSKSSKTSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSSTSTSDEDKKKIKKPKEEIQQQKPKEEIVEIEKPKEIQQQDQQKPKEEIKKRKEKNKKKKRKKKKKRKRKRIKEEKRLEAERIKEQKRLEEEEKKKEAERIKEQKRLEAERIKEQKRLEEEEKKKEAERIKEEKKKEAERIKEQKRLEAEEKKKEAERIKEEKRLEAERIKEEKRLEAERKKAEKQMKKQKSKDEKPKKSKSILSFLKSKKKSKDEKSKDEKSKSKSKSKSKSKSKSKSKSKSKSSDEDKKKIKKVKEEIQQQKPKEEIVEIEKPKEIQQQDQQKPKEEIVEIQKPKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSSTSTSTSSDDDKELDENKKQKKKLREEKKRIKQQKKEEKKRIKEEKKKEAERIKEQKRLEAERIKEQKRLEEEEKKKEAERIKEEKRLEAERIKEQKRLEEEEKKKEAERIKEEKRLEAERIKEQKRLEAEEKKKEAERIKEEKRLEAERIKEQKRLEAEEKKKEAERIKEQKRLEAERKKAEKQMKKQKSKDEKSKSSKTSKSKSKSKSKSKSKSSTSTSTSDEDKKKIKKVKEEIQQQKPKEEIVEIEKPKEIQQQDQQKPKEEIVEIQKPKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSSTSTSTSSDDDKELDENKKAEKKKLREEKKRIKQQKKEEKKRIKEEKKKEAERIKEEKRLEAERIKEQKRLEEEEKKKEAERIKEEKRLEAEEKKKEAERIKEEKRLEAERIKEEKKKEAERIKEEKRLEAERIKEEKKKEAERIKEEKRLEAERKKAEKQMKKQKSKDEKSKSSKTSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSSTSTSDEDKKKIKKVKEEIQQQKPKEEIVEIEKPKEIQQQDQQKPKEEIVEIQKPKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSSTSTSSTSSDDDKELDENKKAEKKKLREEKKRIKQQKKEEKKRIKEEKKKEAERIKEEKKKEAERIKEQKRLEEEEKKKEAERIKEQKRLEAEEKKKEAERIKEEKRLEAERIKEEKRLEAERIKEQKRLEAEEKKKEAERIKEEKRLEAERIKEEKRLEAERIKEEKRLEAERKKAEKQMKKQKSKDEKSKSSKTSKSKSKSKSKSKSKSKSKSKSKSSTSTSDEDKKKIKKPKEEIQQQKPKEEIVEIEKPKEIQQQDQQKPKEEIVEIQKPKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSSDEDKKKIKKVKEEIQQPKEEIVEIEKPKEIQQQDQQKPKEEIVEIQKPKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSSTSDEDKKKIKKVKEEIQQPKEEIVEIEKPKEIQQQDQQKPKEEIVEIQKPKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSSTSTSSSSSDEKKKKEKIDLKKIREQKQNDLSGIKEEKNKTQTKILELKKMEEKQKEEQQSIKQEQQKEQNVLKEIEQEEQELLKKLEEIRQNKKQKQENLSNLNKKYEESIKEQSKIKESSDQQSNLLHQINQNEQNKAKEIEEVEEKIKKREEKKKKKKAKKSKSKSKSKSKPKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSSTSTSNSKSKSKSKSKSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDD6</accession>
    <name>A0A9Q0LDD6_ANAIG</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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        <property type="entry name" value="RCC1/BLIP-II"/>
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        <property type="entry name" value="Reg_chr_condens"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="POZ domain"/>
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    </dbReference>
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            <begin position="504"/>
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            <begin position="427"/>
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            <end position="51"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDI5</accession>
    <name>A0A9Q0LDI5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Scaffold attachment factor b-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDI5"/>
    <dbReference type="OMA" id="QHQNDGQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="339"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
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        <location>
            <begin position="371"/>
            <end position="380"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
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        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="948"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="980" mass="117185" checksum="C96629C196F54A2C" modified="2023-09-13" version="1">MQSSRIVFFFSSIEEMKRASSVFQTIRRVFTLPQRLKVDAKQALKHTLGLVKLSSEHFVLYPVRKKIASSYKISFSDIEIKAKPNQSSSFFVSWRSKKEKLFEYQISCEKQKFTPLLLQFLLFIKWKEKARNQAQRRSGSFTLEKQHFQKDLLFIPQPPKEDQDLNIEKEDQDLNIEKEDQDLNIEKEDQDLNIEKEDQDLNIEKEDQNLNIKKEDQNLNIEKEDQNLNIEKEDQDLNIDSPSFPANFSQNTKSKPLSSLSYFSGNSIILTFKDSNNKKQFNLNSQSVLRSSKKNPNFIQVVIQKNETFLLNFSDSKIKDDFTKTFHLILKELRQNEIDNQDKEKKSKSKSKSKSKSKSKSKSKSKSKSKSKSDQEEKQNIEITQVKPKSKSKSKSKSKSKSKSKSKSKSKSSDSSDSHHSKSIKDTEKDTEQNKEQTKIESNQDNQENSQLNQQTTQKQDSKNESKKLKQKEEKEKKQREKEEKKQKAKEEKERKQREKEEQKQKAKEEKEKKDKEERERKQKEKEEKEKKEKERKQREKEEKEKRQREKEEKKQKAKEEKQREKEEQERKQKEKEDKDKEEKEKEKEKEKKQILEKSKSKSDQEEKQKIIQTVQVKPKSKSKSKSKSKSKSESKSKSDQEEKENIEITQVKPKSKSKSKSKSKSDQEEKQKIIQTVQVKPKSKSKSKSKSKSKSKSDQEEKENIEITQVKPKSKSKSKSKSKSTSTSTSTESFDSSDSHHRKSIKDTEKDTEQNKEQTKIESNQDNQENSQLNQQNIQSNQQTTQKQDPKNESKKLKQKEEKEKKQREKEEKKQKAKEEKERKQREKEEQKQKAKEEKERKQKEKKEEKERKQREKEEQKKKLKEEKERKQREKEEQEKKDKEEKERKQREKEEQEKKDKEEKERKQKEKEKEDKERKQKDKEDKEEKEKKDKEEQEKQKEKKQILENQNQNQNQNQNLNQIQNQNQNQNQNQNQNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE69</accession>
    <name>A0A9Q0LE69_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE69"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="386" mass="45301" checksum="37F4CED9FF5978CC" modified="2023-09-13" version="1">MGIIPTKKIPKKMMKMVTKAIESTAEPIMIIEGIDTKIMKANKSTANMFRCSQISLTQRSLIDFCPTFQPHMRNLSSRAITLCLSSLIEEAQHTSELRISKFHLLFKDELNEEFWAEVSACVYYFENRPIIKLSFEPKSDQSVEHLFPKSTSKSTKNSKSSSISIITESCDFSTVEDGSTDIFYEITEPEPIKKIEPKNPKKDQLIKEPSAINFKIPKLLTSLKPTQSFRTENKKSPRKKKPFYFDFIEFEKKSKLLEKLNESKKLIREKLDFKLEIELIILINKLFGNYEKIIKQKQFNMMNLLDQVQKEKARFSRNLFQCENILLIKLKKFYLLSLENNHKNQEIQYLKYLIEQASLESKIRKEKKMSKNEQKNNDNNFFLLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE72</accession>
    <name>A0A9Q0LE72_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_10509</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE72"/>
    <dbReference type="OMA" id="MECESKK"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="13">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="14">
        <location>
            <begin position="766"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="15">
        <location>
            <begin position="1046"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="532"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="546"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="578"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="621"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="651"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="724"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5071237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1185" mass="139441" checksum="52EEFE922346EDB9" modified="2023-09-13" version="1">MQAKINIELFVSRLQKFYSIWQNNFQEINAINSFVGQINDKEALKISNQFQFWLFGWEFPNTLITFTKNKNIHFVTSQAKLKILQNIKSGAPKEFTLNFHLYQRQQNSQKEVVIQKNQDLIANIFKNILETNDNQEKFLLGFLPNEKIIGEFANLLTQVMKENEEKFSIQDLSDFFSLLFSVKDQTEIENIKTASLITSSVFKKYFLANMKTIISRKKEINHNTFAKKIEQFLLNPSKFKIKCNEELVDSCESPIIQSGGFYNIRFQANNPEILTSSSYSQPEYQLVIESDDLSIYRKMDNDFIFLDRKTQNFVENSTIKFDTIISSFGAKYNSYCTNVSRTFMVNPSQEKIADYNFLNEAYQFLISFIKPDVSFQQCYNVVSSFIRDNRPDLFHNLIKCFGFVTGMEYNDNNFQIKQTNSEKKFQEGMQLIIFIGFENITEINHNDFKLTKDHFISLLNQLQNSTEKNENLELEIEEEKKKIMELILSHNYSLIVADTIIVTNSGIDLLTNSCKRSFEDILFKLEEKDEKDEKDEKDEKDEKDEKDDKEKDKDKDDKDKDDKMDLEKNDEEKSEKKKKDKKHKSKKHSKKKKKKDKHKKHKHKKHNKSKKNKKRKKDVEELTEEFTEETEESNTQEEQTTEDSFMDELAEENKEKEKEKEKEKEKENVNMKARENEEKKTIGQRVLRSSKRRKEEFKRRNRTEKRVHHQQNIAKKIQEAAELRYSKNKNSKENKNDTENNLLQEKQIQSYKNTLDYPSDLKKSRIYVDTEKETVILPINGKPVPFHISTIRNITKNDEGDSIQIRINFISPSSIDSKRYNFVTENANSKIFIKNIEYRSQDAANTNEAYRLIKELRRRVISREEDRIMQQSIVKQEDLVKTQGHVPRLVGDLFIKPTISGRRISGALEAHSNGFRFITKKGEIVDVLYSNIKHAFFFKAEKESMKSILHFNLIHEIILGKKKTPDIQFYTEVGESRQVIDSIQNEHENIYGEDLEEQRDLNLISKVNRIFSNFTKKVESVIQSYFTKINKQTPFEFEDPYRHIAFEGVCDRISGVFIPSLNCLTHITSSPFMVLPINEVEVAFFERISLVLRNFDLVLIFKDYKRPVVQISAIPSENLEGVKDWLDNSNILFFESPVNLKWDKIMDYVNRDPSKFIKDGFWGNIAHSLTKRYESSDSESSFESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEW1</accession>
    <name>A0A9Q0LEW1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEW1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="370" mass="43921" checksum="2E355A7F5E83B558" modified="2023-09-13" version="1">MTQSFILNHSMLVEADFYSELAEKAEQSGDLVQAFKNHQNACESYQKVMQNVKDTQPLEILYNIHYSRAQELQKILQSTSDNKIESKNKSKNKSKNKSKKSEENSKEQKIWNVKNSYIDKEKDLNHQIKISKSNTLLKDTIHVGDNQNPKMNRNSKTKEVQFEDNIQTIPTNSSEIFEEIELESFSDENKEESNQEMNAEKKKRRMKIKIKNQNQNQNQNENQNQNQNQNQNQNQNQNQNDLIQNLENQILHLKLQNKKLAKVEEENISMKKKIQLFRNQLSKSAKSFQKSFLMASQIAKKEFEKDTISKEEILKQLQFEREERKKLENMVEIYQQRWTQLELSARNRRKSQEKISLIQKIDKETQTEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF84</accession>
    <name>A0A9Q0LF84_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eif-2-alpha kinase activator gcn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1440"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1614"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1733"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="772"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2854" mass="326105" checksum="9109317B291DBDE5" modified="2023-09-13" version="1">MDSNQILKEDWKQFLIEGWKFITASSVLKRKEIILNLMKCLSMSETMPMPDKTISFFSKLIFSTLAIYHERESRLIIEKLIEELVKTKFKTKSSKFFVLFFLNMVNPKNPIPKQRYIQLRWTCIALEKLPEEELKSFNDKENAFLLSLFGSLLTSLIYLPNKKLATLSFNLAKHCFYNTKIPILLINALKNFEDYRIIHPLIQLFSSVLIEKNKEIFINELKPKLLEIYTKNILQSRSQFQHKVLDSYSTLLKNITEKDFSEILLPVITRIMNRNPETAIHHLLPLFQTLELDLDAHFSENLLPIVIAEIKSENQQQKKLAFSMFRAIFKTMQNKEEMKKGINVLQEIMNQPSHWETRHTISKCLKIIFKSQHGADLFIDKIESQHLQQMKKEKEPIILAQMIKSIAYAILKKETISENIQKQFIQGLKSNDVQQNKIYIDGLSIISGSNSQNFNKFFLSVIPFFTKILKKDLSFETFVVSPLIIFKMAKYSEEISAKINSESIWKIILDSHKTRNKIEQLKLDRKQILKYSSMIITLVTISNEKRSAKNADEDLDCWKDENYHVLFERIFEMLIDPNWEIRKNVRNQVLRLQKDNEVISSSLLSSGVMFLERKLTEMIKKETEKAKAKILIKIAAKKEKNKKEEEQKTQKTQESQGKILANLLELIATEKAISEQDSRVISALIYVASHPRVQEPSLWFKINKKKVLEEKVQKLNVEVHKNILTKMKKLIEILEQNDESAIKETSEELEALANSYERISKFSWEHSVRLIVNDITELLKEQLQKINLLKKEDIDVYKMSSTDFENFLQKRTEETKNLRIKELKEKLNNEKKTKQKRSRGQRDLYKVEDEKWEEELRKEQQVKKIKEEESQMAKEIYTELSEEMNKTRRKIKGMENAIRVSLSILLTPCNINSKRFYLEFGQSVAKTVFNFMSSIVSYEQSNLFINKMMSGIPSNYIKYRNRILRGLNVLFANDLCEKIEGEPNIREIMRSLVSMIYSECFNEMTQKVTPLDSTTFTLVYPFARYILTLPYLYEVHEKCISLVFFHTDPKFVIARKEISGHLLQVPENTPNLIEQTQKCIVGLFEKWKIIEDLEYIFEGLISTSSVIRIICLQTLLKSEAMNIEIEKIKNEMVLQNQIMSENNENQIQNIKDTFQYFDNKKAANIVISSYDIESEENRKTAKIILERLGFLEFAGSKNMKKFDDMIVEICAHLSSKDLNIREMSAQAIAEVVNMSNSLEFLKYIFDGFTKVYMDLMEKETEDRSTDDLGIEVHLDNEDEDEKSGDENENLRKFGDIGERYLELRHGIAVALKYMAQRGLFSTENMICDALEFLITKDHALSESIEEIQKELLDLGTELVDKNPKESVSQGMKMMQDFLARKPENTIEDDKMREGALIILGAMAKYETDMKKLEQIFKQLLDGLVIPSEIVQSTISRCVSSLVPKITSELVDSSMNFLLQSAIQNKKYGIRRGASYGIAGMVLGLKITSLTKYGILEKIEEAGKSPSGINRQGGLTLIEILCLVLGNKFQPYLSKILSQVLNAYGDSDSSVAKLAEQTSRAMFTILQKAGVKSILPLVISGLDNESWKTKIASIEMLGTVAFCAPKQLSQTMPMVVPLLVNLIRSPRQELRKSATKSLKSISEVIQNKEIKEHAPALLSALEDPSKHLKNALDALLYTTFVNYIDAPSLALVFPTVLYGLNQGQTEIKKSASRVVGSLCSLSRPKDIQPYISTILPKLKQLLSDPIPEVRGDSALALSKLVRGLGMEQFPSLLEWLLQRIKTTEGHIERSGSAQALAHILGVIGIEKLDQLLPGFVTSITSQEAPIEERDGSMSLLRFLPMAFRDGLHAHVDTVLRAAIKGLSDESELVRDTAMRTGIAIIEQYSQSGLSSLLSQFEVSVFDQNPRIRINSLELVGQLLYRVSFSTIEKKEANYFGDDIFIKPIIDSENTNESIEKIPKNEKKKSKKKIKITRSKEKDDYTQDVLLNALGEEKFKRILAVIHISRCDENMNVKRAASLLWNRFVTNPAKTLRQITPTVLKTTLEMLQIQDIWLKKLAGATIGDLIRKMGSTILTSILPLFDENLESPDPSIRQGACIGLSEVIYSSGKPALSKFMDRIVKYVRIAICDLDESVSDESANTFDALYSVFGSMSVNAVLPEIISMIADPESRERGLMGLQKILLKRGSVVLSYLVPHLLYPKVDFYKALAIEKLVGVIQENLPVYIDKFIPSLVEAIAIESIDETKENIKETKKTKKSKKNLKKSKDELTFESQKIEIPKEIISKEQLSTQATKAANALVVAVPSSGATKLLSALFKLFSHKNQAYQLASIQLLSEFCKNPNIKLGNHLEVIFKAVFPLFTNKNEKASTAAWNVISVITKTISVETISNHFHQIKDTITQLVMSFNIRLPNEEKIPGFSVPNAFVPLSAPIIWGISEGMNDIKEQAAILVEKFATYSQIQYSKMLLMKFLGPLIRIAPEKITLDVKISILSAILCILKKSGPLLKPYFVPIQSTFIRSINSSSMKIHSIVLDGLTILSQHQQRPESLLIEFYKAIEPNSEYFSSDTVVLQDSILIMLRNIIRNAGAKIKDDILLKFMQFFIKHTSSSESSFRKSLAKTYGVFFKFIKDKKTKFDQINEIIENVTNFFSKISNQQLPSDLDTEQGLIAILFFITKYNASFVQSDDLLSKKIAHVVFQLLQAEKIPNQQFGTKIAFKLLSRNSSDLKKEISEQLISLITKNISSKSSEVSTTSMQFFRKISAENDYYSNFELPKIAEPILTIAKSINIDSNSRMIAARALIAIFRFDKDQQVIDSYCKNFPKLKKNNLVEFLETLLLKLKQNNFETSDSDGEKLESLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFA2</accession>
    <name>A0A9Q0LFA2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFA2"/>
    <dbReference type="OMA" id="YRTWKWN"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF449">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040138166" evidence="2">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="422" mass="47773" checksum="7D430232E12F9E67" modified="2023-09-13" version="1">MNLNLITYIITAIFLLQTIKTHPKVVINNITKEETRNETETEIAGYTCYSGYILANETSGAYLFFVYIERNTSNPLQLVLAGGPGCSSSDDLFLALGPSLIQPDGSFINNSNAWTDIFNLLFIDNPVGSGYSYIDDPDGYPTNQSLVSQQLYTSLLVFFDKYNISQDKDFYIYGASYCGKYIPALGYKILQEGFVINLKGVIIGDGITDPVSQMNYSYYAYATGLIGELQYPIIHAKELECVNLMQNESWLDAANCMIDIWGEIVNMSGGVNVYDIRLYGDYNFTALDNFMQSNSTKETFGVDLNTTWWDCDGPPTHYLYEDMPKSVKSDFEALLANGTKIFLYTGQFDLIITLVGSLNFLSNVNWEYMDDFNNSTRIIWKVDDEMAGFVKHYKNLWFGTIVDQAKHTHNLAYRFVNDLPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFB6</accession>
    <name>A0A9Q0LFB6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFB6"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="233" mass="28247" checksum="5501FB1F5C81DB1F" modified="2023-09-13" version="1">MNNNNNNNNNNNNTENLKELYKLSIKEIDNILLKEQSLNFSKIYQTQKQFTDFTIYCKEKKKENENENENENENEKRNKKRNKKEDERENPIKCHKIILNARSSFFDLFTKEKGENQIYFKEFDFEIVEPIIKYIYEGEININHQEFEKYFKFADIIKLEKLKIKIEKEIEPIINQNNIFEIFSKSKEIQSDFLLEICQNFVLKAFPASKNIFFYLHLQKIKCNHSQKIEKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFY1</accession>
    <name>A0A9Q0LFY1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_10614</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFY1"/>
    <dbReference type="OMA" id="QMETEND"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="273"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5071130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="334" mass="38394" checksum="EE2F6426347F8023" modified="2023-09-13" version="1">MGLCSSKRKRLNLNSFEIHFLIGEGKYGRIYVATQKSTKQKYAIKMIPKSKLLENKMVEHAFQERNALSLISSPFVIKMKHCFQDEDNLYFVLDWINGNDLFDHLINFTTFPENITQFYAAELILALQDIHNKGFIHGDLKPENILIDPTGHICLIDFGSSISIEKIGLNGDIPVFGSYQYMAPEALKLGKPGFAVDLWSLGAILYEMVHGRPPHYAETQQQTIDNILNEELEFKPQISDQLKSLLTGLLQKKPENRLGYNGIDEIKNHPFFENINWNKVAKKETNPVLVPGPKHIFSDHKNQLEELILLSIISKKDQKFFHNFEFNPFVDDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG27</accession>
    <name>A0A9Q0LG27_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG27"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="383" mass="46608" checksum="ED1461C0CE78C2CA" modified="2023-09-13" version="1">MDKNNNNKEIENENQIQNENEIENQNQNQNQNENQIENENENEMKNLEKKVTKNLIKDYSNLLNTNSFKDFSIFVENKSNPFEIKVHKSILFSRSPFFNKFLRQESLFISLNQFNKKEMESVLKYIYYGNISFENQENLFQLLEISIYFKLNLLKEIIEKKISNLINYSNFFQFFFQNRNFDSNEIEMKCFELINQKFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRVNSLKGMKEEQKENMKKTLFHSFFSLFDKDSIPKQDFDKLKQFDLFPKSFLVDIQNKVIQDNREMKSENLKKEKENKDLKLENESQQKKNQDLKSENLKKEKENKDLKSENQNKLKENQDLKSENLKKEKENQRFEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGA6</accession>
    <name>A0A9Q0LGA6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TBC1 domain family member 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGA6"/>
    <dbReference type="OrthoDB" id="73307at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099041">
        <property type="term" value="P:vesicle tethering to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039755">
        <property type="entry name" value="TBC1D23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297:SF5">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13297">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="334"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="507" mass="59896" checksum="C282E36462507558" modified="2023-09-13" version="1">MSFAIQEWVNSNDKKTFRKEAWKELLMIENFEKKQPIKKIEKITYDLIIKETEIASNIIKEMTSKNLSKVIQASLIRIYEVYEPQYTKGASILLVPFLLLDLDFQEIADFFYGFQKIFVPNLYKKESYYRLCGFKLVRHLLLYHDPDLVQHLDQFRGDITKIATNSIFTALIYFYINSLKFFKLKKSEDSTQNFSEQKITLFNNFYLIWDYLLLSRDPCWIVFLICSFFLIRKKEIMNANSHENLQLVLDQLHFKMEDNPEEIIHKARQIEFKTPISFKQLMMNTLYSENGKFDSNQYFYISKFVALPIDLVEILNLWENNKQIEEKNAKKLSFVVIDCRKQEEVSFGTLPLALHLDPSKFFDDPVAFTENLEVFLAMKGSNLAFLGTGNLNQDKELFLIVLQFITRGFPHVSICQGGFQKYLDFVKEGKCKNQQKEEKKNKEKQKESEMKQKQPQEIFSIYDSDDNLDENLSSDQDKINDLINEIINEEDDLDDLDDLDDLDDLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGI7</accession>
    <name>A0A9Q0LGI7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_01482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGI7"/>
    <dbReference type="OMA" id="EPMEPPM"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="556"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="843" mass="98523" checksum="9569930A4228FDFA" modified="2023-09-13" version="1">MDSVSTLQQNDLKFTFIPSYEVDHNVTVLIKRFDGNISDDYVHSFDDDPFLPYSGVYCQEPSNFFIVAELFSGGQSLCVSRRTRYKPTKSYSWYELIQFPFKYRDLPYDTLLVFTIYDIYSPNSLIIVGGTSIPLFGQKSRKLRRGEYRLLVWLNQRGDGLSQSKTLGNIHKTEDIGKLEKYMRKYKHDIRFEIKPKVDWLDDTILDHISKIFSEDSENQRRFFLLVEFPTFRKKKITNETMKFVHEEIMFQEKLLKEPIPPLLAVMAKPPNDIKCIWDPEIFKDNPVEMKNRKLTRSRRTELDRDLKPNVEEIRKMEEIIHQPPTKNLTDLEKELLWTYRYSLTKNKKALTKFLRCVDWTDKSEEKQAQELITEWVQIDTAEALELLSSSFQSKIVRKIAVDRLRETSDEEVLEYLLQLVQAIRYEKDPLNSDLMNFLIERSTLSQIFASCLYWYLVVATEDNEYGSMFTNVLAKFKYLNSISNPGAMEMLNRQKNYVDTLTKLQESIKSMKENRPKKITKLRQLLGQQGKFSGLNTFEPISDPLNPNIIVSGIRHETSYIFKSALQPIGLDLKIDSESFTQNYGIIIKLGDDMRQDQLIIQMINLMDKLLKKEDLDLELTPYKVLAVSNNFGFIEKVNDVKAVAEILKKYKSIRNYFRKKYKNSESEYQKDEKKIIENYVKSCAGYCVITYLLGIGDRHLDNILLTPDGHLFHIDFGYILGRDPKPFPPPFKLSKEMVVAMGDLASPEFLSFKQYCCEAFNILRKSANLILNLFSLMLDANIPDISRDKDGCLLKIQQKYQLDLSNEDAVKYFQELIHESYTSLFPVIVEQFHKLAQAFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH55</accession>
    <name>A0A9Q0LH55_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear-interacting partner of alk</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH55"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="466"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="547" mass="64551" checksum="2B60DC98BA05F96A" modified="2023-09-13" version="1">MSVWNQGNWHWEEKDYSKWACEKLDKDVLNLEMEVENGKISISSSKTKGDACINIRKGKRICSYDLKMEIDWKGKVGDIDISGKINISDVDDSTDTDDYVIKPTINLNEKTKKIEKKEKEKKLEEKINENKTNKKRNKRAEPWNKEDFNHRVKSFSLVHWFSNIFSPLEIARFGFYCSEDNSLKCSFCEAKITKKQIKENISINSGDLSCKFLNDFHSDFCPWKGNPCPLSFATISDDCIELFHQFLSRILSLQKITSFPKIDFQIYSKIKGFFDGVTNIIGENLQISNFHDSLRKSFKILHEVYSVDVLQNQEKQKIVFILALFGWEVHSFKKKNIKSYEILKCDKCQRKIGLWNYQKFEENENENEIENQNQNQNENENENENQNQNQNQNEIGNENENQIQNQNENENQIEIENQIQNQIQNQNENENENQNENQNENQIQIEIEIENENQNQIENQNENLNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNQNETEIENQNQNQNQNQNQNQNQNQNQNQNQNQNQKSKSKSKSKSKSKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHK2</accession>
    <name>A0A9Q0LHK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHK2"/>
    <dbReference type="OMA" id="EWIPRME"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054472">
        <property type="entry name" value="WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22977">
        <property type="entry name" value="WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="280"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="532"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="753" mass="85802" checksum="AC6316C6862CCD53" modified="2023-09-13" version="1">MDISQWISEEKIHEKKTVKTKNIEQTAQDKQAQEQQSFPDLKPYANDFEYLEDRFEMYANKLNLIQEKENESQTFYIDSVFHSQALVREFSAKDHSLRTKCEQRLKLTEKNGEWIPRMERLAESRKLTEFEKNVVLFLIGIKTSQKMLAVLNWRQVTVEMLLKMFCKNLKEQVMNRKYFYKSGSLVRDRIIQFSGSMLESSLNSMEVFVDRRMVDFVLGLDTEMEELIEGSHLYTSTVKMDHVVLREEDKRLVLKTVTNYDHFAKCRKRLGLDDAIANSGGLVLLFYGESGTGKTMMANALGNELGRKIMLINFPTLGKNTAGEIIQYIFREANLHNALLFFDECEGIFESRQKGQYNVNLLLTEIEKFDGIIVLATNRAFDLDEAMHRRIALALEFKKPDPLLRQQIWDAHLPKSIRYDSSVDLKALALKFELTGGFIKNAVLSALSIAVSRDGLENVTITQEDLERGAKLQLRAKLRMTDFHRRIVPQRGLSTLVLPPKTLQLVREIIDAEKSRLVLDSWGFDTSIGFQAGSTVLLCGPPGTGKTLATEAIAYEIGRPLKVINAAELVSKYVGQTSKNIDLLFTEAKNNDSVLVFDEAEGLFGTRHSAQKSSTDRYANIDVGLLLYHMEKFNGIVILCSNLVSAIDPAFFRRMRFVVDFPMPDQGLREILWKKLIPDSAPVLSDSIQFKLLASSFEFSGGNIHNSIIRAASKVALRPRDSQTITTDDLFQAAQKELEKISKNIDKNQSYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHL6</accession>
    <name>A0A9Q0LHL6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LVIVD repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHL6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040483494" description="LVIVD repeat protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="78762" checksum="14DC91DE56142780" modified="2023-09-13" version="1">MKSKLILFVCFTSFLLLVQSNVQIEEVFTFPISLYSPYNILVDSDEGFVYVVDQMGMSIPDSFLFKFDMNTFEFIDAIDLGIKGAEGAVIDTVNKFVYAASDYNPPVQISKVDLKKFEVVDILTLDIDVQYGASIGQIDIVNQKAYFGCDSPPVVVKIDLTTFTQETNLSLSEDWFDTLMIDIPNGFLYASTQSISTDNSILYKIALSNFSVIDNIGFNTLNEMPIYCGAIDYSTQKMYLGTGQSPPDVVIIDLTNFTKQDDVNIPTLEYSSGIGIDETNEFGYLIDYNGVMAKMDLTNNSIIDTLNTISDGSYVQSVVFDFEIEKAYITTNNPELIEVDLSLFQVEKTIIPQDYSYPVLFLIDESNQIGYFEFYISNNPSILKFDLQSLSIIDYLDISQECDYGEIDTLNGFLYLFPTSSNGLNIGKLRLSNFSFEGFNQIHDNGRIESITFDEQKGILYFGYLNNDISNYEIIQVNVTDLTIINNSNFGSQNAILDINIDTSNEYLYSLYSNNSDYNYYLSKINSSNLNIIDNLNFEDSFTEYFFEKTFQYFYFQNKTNNLISRVDLTNMIIMNDSLNVTSFYLTSNYFESNDDSIYLIGSNSSSSDNLVNVLEVELSSNQLISNATLEYSWQSLIIEDDSSKSRIYLLNSDQEPYYLYEIQQPTPTPKPSSSQQILFSIFILGITIILGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHP0</accession>
    <name>A0A9Q0LHP0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_08668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHP0"/>
    <dbReference type="OMA" id="ICVASMK"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF9">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5073551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="279" mass="31668" checksum="336B66D062C99BCF" modified="2023-09-13" version="1">MSEIDISGDGGVVKTIITEGSGDKPKKGDEVSVHYVGTNEKGEIFDSSRNRGQPFKLTVGTGQVIKGWDLSLPTFKIGEKSKVVIKPEYGYGNQTVSDKIPANSTLTFEMELLDIIGGEEPLEVKITKAEKAKETGIALFRENKLQEAIEESQKGLQLFEEWKTEDDPEDEEKKQEIILKLSLNVALYQLKLEKYADVKKTCRKILEKNPQTLRALYRLGVAEMNLGEFENAVTTFKKGFEIEPNNKDLQKQYAILKQKVSKYEQEKRELYKKMMSNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHT6</accession>
    <name>A0A9Q0LHT6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="7 11">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_09042</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 11">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 11">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="7 11"/>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHT6"/>
    <dbReference type="OMA" id="QALYMGK"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7 11" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="177"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="31"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="72"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="9">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="9">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5073087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="474" mass="52922" checksum="8652FD1E6C61BBEC" modified="2023-09-13" version="1">MADIGVIGLSTMGGNLALNIERNKFKVAVYNRTYSRTENFMKQNGDKNIVSSEKLEGFVNLLSKPRKIIIMVVAGKPVDSVIEQLLNYLEKGDLIMDCGNSFFEDTERRAIMLEEKGIKFMGVGVSGGEEGALNGPSIMPGGSPEAWNDVKHILELISAKADDGRPCVDYIGPRGAGHYVKSVHNAIEYADMQLIAEAYDILRKVLKLQPQKIAQIFEDWNKGELDSYLIEITSKIFKKIDDKTQKPLVDIVLDKAAQKGTGKWTSQNALNLGAPIPAINSAVVERVISSMKEKRVIASKKLFSGVDEEKAKYSGSPEELIESVRKALYASKINAYAQGMELLLIASEEYKYNLNLGSIASLWRSGCIIRAKFLNLITQAYEEDPKLTNLLLYPYFTNKLKDNLADWRKVIQIAVGLGIPVPAFSSSLAYYDSYRSEFLPANLIQAQRDFFGAHTFKRLDADLNENFHAHWEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI72</accession>
    <name>A0A9Q0LI72_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI72"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="387" mass="44439" checksum="559B67BA4692B38E" modified="2023-09-13" version="1">MNFKQFSNINFEEIDENETIIIDNGSSTIKTGFGGDDEPRIIFPSIIGRPRHYGIIVGMNIKDYYIGDEAKSKRGILTLKYPIEHGIITNWNDIEHVWHHSFYNELRVAPEEHSLLMTEPPLNPKANREKTTEIIFETFNIPNFYLSNSSVLALLQSKRTTGVVIEIGDGVTHSVPIYEGNILNDSVLRMDIAGRDLTDYLQKIVCERGYAFTTTAEREIIRDIKEKLCYVSLDFYEEMELSSYSISFEKNYELPDGQIITIGNERFRTPEVLFQPSFIGMSQSGIHEIIYNSIMKCNVDIRKELYGNIVLTGGTSMFPGIKERIEKEIKQLSPKDMKIEVISPPERKYSVWIGGSILSSHYIFKNLSISKKEYKEFGNSIIHQKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIH0</accession>
    <name>A0A9Q0LIH0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleolin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIH0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="933" mass="109117" checksum="614134C211CA10D7" modified="2023-09-13" version="1">MTTKPYQTNFYNKKDEFEQKKLKSLQLNKKYPTKEAINEIVINNFVNGFVQFKVAFQNRSIPVKIEMNSLGIILYIQSEDLRKSPLYHFQNINLMLSQENQNLFRLDVSDTESFLFLAADENQRLIIFKTFLMMKNYQNLTKIIDNTFYIFGNILNDFDEMNALLLRSYFQGFVNFHLQTQTFDGQKLDTNFKLERNYFILSIENVEPLVVEWDAIVNISLLVSNNSLLILEFLNNKKIYLDCGSTKLRFFLFRMIRFFQEIVSKTTSLMSVDSIIFDYQPYIQNTAFQPKNDVSVNTNEKYKFNMVKFFQQPRQETIYSSTLNLTAQTSNLQIQESTSNLPKDPSLIIRQPTVQAQELAQEQAQELEKEDEIDLEQDRLPLEIRQEMVNDILEELPESPILFYDKSLKINTNAIFEIEIFEDLNPVFKPAVIVFSKFAVSIFQENVRSTIHIIDSKSNISSTKRTATVLRVLFSNEKIYLIRFPKPQKMRKFADIFLQIQKNPLPETHRYRYFACQAIHNGKEYGGTAIITPNTFSFLFPTFIKIFELRKGLKSFTHNKNPRMRRITYLNEELKLYFYTKYSSNKFAELLTEKKASVKEIEVDMNIPSSYNVTIVNNKKRKEEAFIILSEESFIIKLEKEQGDHIHYIDSDSKIKFDNDNHLKCKIILDVSYEFCFNDFEDRVQFAVRFSQMSLKIKKREDNELKVSGDEIEISDLDSDKEKPKQIESIDLKETVDKIENLDSSEKKDSSEKKDLSEKKDSSEKKDSSEKKDSKEKKDSSEKKDLKDSDKKSIDDPKKIDNIIKSEDSDTSSDTDSFSSTKSSDDKPKKQESDHETTQQEFTFHVQINESAQKRGAGEITLSTQGITIISSSKTYKAPYKNCKLLKSSRNPIWAKLEVTEDFHPAIKFDSQIESSKFFKKYHEFESLTNLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIR7</accession>
    <name>A0A9Q0LIR7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIR7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="82" mass="9835" checksum="D2E2E72324EB4504" modified="2023-09-13" version="1">MMIFSIIMFLVELGVHFFIILLSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNEIEKLQEIISKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIX2</accession>
    <name>A0A9Q0LIX2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIX2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="204" mass="22700" checksum="C8871C78DE3D3ABC" modified="2023-09-13" version="1">MSLSLYILRFIAFCCVLGATVLDAISIGTQGLFYYKYTFVSTNFHFGNFESGCSGLGCSNYTPEKICDWADDLNRFKGVLANGFLCIPGFFLLLNSLLFINKEGSAFFFSLLGSLCVISGYGSFRIFFKDSEYYSVLQDMKNGGDITWDYGTNTTLESLSFVTGFIGSVIFLLLFIMRIKSEGFSSYISSSPSPSDNHGKYHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ65</accession>
    <name>A0A9Q0LJ65_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3'-5' exoribonuclease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ65"/>
    <dbReference type="OMA" id="NTARIFQ"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="211"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="317"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="516"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="582"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="620" mass="71790" checksum="51CED2EF95DA3CDF" modified="2023-09-13" version="1">MEIDYFLVLDLEATCGPGIYENVEIIQFSVVVLNLKNNLIENKFDSYIKPIIHPKLTRFCYKLTKITQKQVDNSQIFKEVLIKFEKWMIENEFIKKDGTKIKKFHFLTFGPDDFRKFLLTQLKISQIKSIPSYFNYFFDFQKYFKSKNKRKYRIGLSNLLTDYGLDFIGQAHNSLYDCINTARIFQKLSNEIPFKITENDLDSIFNEIEKDVIVISNLPFSLTETELKEEISKFVGVENVLLCQRDGKPTGNGYVHLKNSSDTQKIIKLLNQTRFFGRIIRVEMAKKNSKSKKTKNPKSKKSQNQNQNGSEKKKSKTGIHVSNLSFEMKDEEFKKIFEKFQVKEARIARNKNGKSKGFGFVEFETEEDQKEALKLNGTEFFNRKIGIRISFEESEEENNKTEIVSNQNQNQNQNQNQNQNENQNQIQNQNQNQNENENENENENENEDENEDENSNSKSNSNSTSRFNPKSNSDSNSNSTSRFNPKSNSRFNPKSNSRFNPKSNSRFNPKSNSRFNPKSNSDSNSNPTSRFNPKSNSNSISNSRFNPKLNSNSNSTSRFNPKSNSDSNSNSRFNPKSNSRFNPKSRFNPKSNSNSNSTSRFNPKSNSNSNSTSRFNPKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJL4</accession>
    <name>A0A9Q0LJL4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_00660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJL4"/>
    <dbReference type="OMA" id="YQEGYWA"/>
    <dbReference type="OrthoDB" id="419508at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040535721" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5074032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="550" mass="64013" checksum="D7B6162024C6A8C3" modified="2023-09-13" version="1">MKDLIQIIIFTLFCFSFINSQKATVYYQNGQYSLIKGSYDFNGAAWGSYNDSLDLIGWGQLNVYTNPSYPDSVQMHAAGYLEGALTHSRIFQHRHNIFDWMLNHYAPNKIWSPSLYKFLEDNLNYTKNNIKKYAAEDPYWQATGYILDQFEGLVEGYQKYYDSGEKLTELDLFMYNSAGDLLDLATAASPETRPKIEEMTEDEIMMRHFGFDHCTGFIKLADNYSDIFVAQDAWFTLGSMNRIFKHYEFNLNDPFIKCHKLSFSSYPGLLFSFDDHYILDTGLAALETTFDIFNMSLYDLVQPKCILEWMRVRIAHSMADTAPDWALIFSRENSGSYNNQWLILDYKQFTPGTKPKENTLWCLEQVPGMIVSDDITDTLINQTYVPSYNIPSFEIIFNITGYPAMVKEYGDFWSYVNCSRAKIFRRNSSEIQTLEDMKKIMRYNQWKTDPLSLYDPGNAPCSRYDLKPLNTSRREAFGGLDSKIVSYESAQNMTVYAISSPTYDDQPVFKFSTCPFIFEHVGLPDTYDFPWQTFEWVDDQKPKKQNKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLM4</accession>
    <name>A0A9Q0LLM4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btb poz domain containing 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLM4"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="151" mass="18049" checksum="7B60D24A06A334C8" modified="2023-09-13" version="1">MNCPVCQIDLSHLNQNQIESHVNQCLDNQIQNENQNLIENQNENLIEIQNEKIICQFCQKDLTDLHELRRREHLNRCLDSWEGKKKIQKDFENLVETEAQISKNQDLIFNDLNFCRVCGKIIRTFRNERTHLPHFELCSFIKSCFLFSDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM30</accession>
    <name>A0A9Q0LM30_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM30"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="178"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="294"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="371"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="463"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="568" mass="66299" checksum="34392EA55111059E" modified="2023-09-13" version="1">MNEILFFGSNKEPIFLENKSDKILKPIQFKFENQNGNENENEKQIKQISSSNDSTIFLFKNGKAIEYSRYSNQNPQKSKLKIFKNINPKNTKEFINISSLIEDKNDRIIEDIVSGWDALYLLTSNQNVYGIGANYDGHLGFDSETLYKTEKPILMMKNVSKIFSGNCSTCAFLLNSNQELFVCGGNFSGKLGLGESIKETKIYKLTKIQNIPKGKIIDIQCGNFHSIMLIENENQNQNQKRKLYSSGDYHWNGLGKDENTYEFTEIKSSLFEDDDNILEISVTYKHNLILTSNGKLIGFGLNQYGQLGTGNTNDQLIPIQIELPKLRFNENISNYHISCGAFYKSFFYYSPSYFSNLEEDLIKLFERKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDIIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNESFQIFEYWIYSNQIKEGIQITQEIIDEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LML5</accession>
    <name>A0A9Q0LML5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Wd40 repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LML5"/>
    <dbReference type="OMA" id="SICIHEW"/>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000320">
        <property type="entry name" value="echinoderm microtubule-associated protein-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005108">
        <property type="entry name" value="HELP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF33">
        <property type="entry name" value="HELP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03451">
        <property type="entry name" value="HELP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like first beta-propeller" evidence="6">
        <location>
            <begin position="85"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="7">
        <location>
            <begin position="600"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="721"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="833"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="331"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="869" mass="98085" checksum="E5BD007854E88F5C" modified="2023-09-13" version="1">MSKNKGKREKIGAARLTSVEFPIPTKFEEEIKKNKGEKPEESLELEHIYGYRGRDCSANVRYVDDNNILYYAAAVPIVNNKIENTQKFFTSHDDDVVSMDFHPSKRIVATSQVGKHPKICVWNVDTQECLSEFTDSTLDGGITALAFSPSGELLVAIGIMENSVVLFDWEFKRALLYGKTGGDRIIGCTFSSVEESEFVTYGVNHVRFWTITEEKLVSKKAIFGKDAKIQRQNCIAEISDPKSNTNLFATGTVSGDIYVWKNSQCHKIIPIAPKLYEKEKTNEDEKEKTNEDEKEKTNEDEQQKDEKDEKEQKSTEKKKTTKKPTDKKPTTKPTTKPTTKPTTKPTTKTTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPIKTTPTKTTSTNKKPTTKPTDKKPIKTTSTNKKPTDKKPIKTTSTTKKPTDKKPNKSGLSLRDRLNPDAKKTPTKQQQQQKQKQKQQQQKKQKQMTEFAKGEIFLLKDIFKKQTSLIQLKSRGRNLRSISFSSDETHAICASMDGKIFEIELNEENINEPNIIVESHSSDGMAELWGLGMFYSEHKFITTGDDKKLMLGNCDKREIILTKKLKQKSRSVAISPDETLIAIGFYDGSIELRDATTLEVLDSQKIREEDISVSKFSPDGKILGFGSHDNFIDLYQIDESKKLNLYTTCKGHSSYIIDFDFSKDSKYIQSVSGDYEVLYWSAKSGKRYTSPSKLKDVEWQTWTLILGFPVHGIWEPDMDGTDINTVDRNPQEDLLATCNDFGKVSLFNYPVVNKDAKKKKYSGHSSHVTKCRFSFDGNYLLTTGGMDGSIFQWKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMP9</accession>
    <name>A0A9Q0LMP9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase faf-y-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000022">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="1703"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2228" mass="263670" checksum="93A465889BD904DD" modified="2023-09-13" version="1">MQNDSKENQKEKTQSFDFINELINFQQNLKQNFGEQFIKILEQMDNLLNKFQENQENHELIIIEFGKNLLNILQDLRRRVLDNSASSVLMKFYQSIIIFSIKHLKDSNYQNILEILSYLFSNSLYSFDNVSNLIKNDSKYQKKRHNYTKEPNQKKRAKKKKKPKLVILGSKDNKTSLYLLSNIQYFGENEGFEVLIESLKIDENIFLNENENENENENEMNQKNRMEKNQKNLESIFNYIKFLQNIDEFLNTFTHEKYIKKFIDIAYNELEKIFKYEIPDSNNFTRTLNTSLSNMKKLMQKIPSLNHLHILEKSIQFKMEISEILLDHSRIEDQSLGLTTISSLIREIRDLMNGSRNDKISRSRRKIYSSESELAIKTFMNWLKEKKIIEKEFQREKKNTNNLKQMNVIILFYGTIQDFPNDILDYIWKLSQQNWDSNRPLKQALHSNLSAVSQIATTKQLKQFDEYFRKIPKEKYDFDFLEVLNNFTIAMIRKIPKKEAKKSFGISIMWKLIQENSGVSPSLSTKATSNLKNLLNKPECKSIRSFYQKLCVQNIEKHTTILLSLNLLKNIIFREGKDDHYDKINFKAIENKIHDLEKKKHIVDILLNDFDVYHKNAKEQAYKLSNLQKEISSELSSNSKIQSEKIESDILEISKLVENNENIWNYNSDHFFDIDISTTYLVGAQSHLENIQQRLLFLTFILSNSKITLSLSQFNILFKILVLDSIAKTEKDLLIQFLLSLKLNNAEIGESFTTEDLQFISTKIIAKLDFRHSNISEYNVFQKFFIALNYRLKKITFKNEKVESSQQDKSPSQNRPRYFLRRNQSNEDLTNQYSNIPKPDNLFICSPSLFLIENLWDLILYATDSEVIEQSINFMSKLHLSLSSQFFKTPESQKNFYHQFISFVMDRISQIFESESNSKEKELVKSNEDQEKICRYLQLLQKFIDLYDAKYFPENMLSEYLQPHRLRLGASQLNLVFNYEENQFMVIIHNTSKAQTLKQIISKQIEVNIEELTFFVDKKTLKSDDKKLYSIGINNSSSIIVKRKTVPKTQTQNTTTQKETNDEKNKESSVPKKNETEPKEKKKLTKDEKKLQKLRKKYYKKQEKQQKKLAKMENKLEKMEKKKEFKKKKKQQTEKDEIGKENENEKENDENSKPDRFPAILLSQKDNFDILIKLFTLSLKVGQTTWELIQKLPTNSILLMQLASLTENKLKYFGDQIKNEEMEKKENDLDAIISDNYYQLLYILDIIQIMTIVDESQREENISKFGNLRDDEWCSAFIEKKGFARLINIITKYSEKLNSKENKNNSQKNQKLNTALISVLNRLMEIILFIISVQPPQRMESPIPKILHQELQESTKLDDILSQFFLSVCQLILFFSIESNRTDISQEISQNCAHFIESSIVVIGLLFRNKPSIISKIKEDYLLAIFLNLIEYSVLNSNSQIRSAISEFLYILLTYLISINDFQGFVERLFKQLIIETLPQVEKASQKSSEYFLLTTRLLNYSQKQGNEEKMIYPFAIFIEKFGIEKFIGDVVSYIKNHPLIEKNSILENTDWTLKGFFDLLYSLIVIFNFDANFKEEIGIQKGLIDELYENCLFPSVEKNPDENSNSKFEEQKFMEKLQKENINELEPLFQKQEILEIKMPKCQTQHSRTSCFNLLFGIIHHSSKNIEYLMEKMKTQLRNSEKISSWDFTPSVMGTEKNIGYLGLKNQGATCYMNSVLQQLFLAPEFREGILASNLKKKQEGEEISDNEKLYEEFYYLFQILQNSHKTYHDPISFCKNFKDLEGNPINLHQQQDANEFLNMLFERIEDQLQSSEQKNLLKQTFGGKLIHQVICEESSHRSEREEPFFTVSLQVKNKTSLEQSLDLFIAGDLLNNENQYFCTYCDKKVDAVKRCCFFSLPNTLILHLKRFEFDLESMKNIKLNSYLEFPTEICMKPYTLEEKSLKSKEIEIQNRTKPDDYYNYKLVGVVVHSGSSEFGHYYSYIRERTSKNQSTFLWNEFNDTAVRSFDINDLSKATFGSKKNANEFEKRYSGYMLLYERKTRYDYETQEPKEMKLKQQNSFELMKKIRRQKMMQKNNEYRIYDPKYFEFLMTFLQDFQSIQELKDHQIELNTFDIVKFFTVFSIDIILHSKARSEFNIWMKFLEKFYTNEESSKWFINNCIESSWIESIIVKCPFIEIKKEFVHFIDSVAKVLSNFEKEKYHEFENENENEIPKSFLIRLINHLLLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMR3</accession>
    <name>A0A9Q0LMR3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Suppression of tumorigenicity 5 st5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMR3"/>
    <dbReference type="OMA" id="SEEFNTH"/>
    <dbReference type="OrthoDB" id="10266080at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF0">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="11"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="554" mass="65894" checksum="38B3065C231C0F89" modified="2023-09-13" version="1">MENNKEKLFTHFFLVKLLKKNIGIKNKSAVVVPFCLPKLVTSQIRKNIRSFCFPVMNQFLNIQEDKVETFSFLFTKEDGSRLYASCRRILRKNKDPDCLVLLSKQPIFRLLDSILEKSEELNNNSITKLINFISELDKLEMPEMGTTFEISVKKSQTNEYEKFTFSRHENEYGDQYTELLFQTLELEVITSIFSSLLLERKFIFYSKETYLFSNIVLNFISLLEPFTWINVCIPVLPEKLTDTASAPMPFILGVHADLMQTIQELPLDDVIMIDLDSKTIQYTNRDLDLLPEKFINKFIAKLSRHINLFREKQQFDNQIIHFEFLDFFIEIFANYPSFMIYSEKDNQYIFDSQSFTSSQPKILRKFLLDFQKTQLFEFWQRNQEKNYPNLEFDNFHQRINNLLENKKTNSKIMKQISKGQRSRSNTHTPNSPREIPKISMIMNENLNENLKENLNEKNLNQKISRKNSIEKKEKNLIEKKERQKPHLLSQRYSFDSKDSIDIPKKISKKKHRNVIRKKIISNQNFEKEKQNEETNSFRKTNTSQFTLIFKTNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNF5</accession>
    <name>A0A9Q0LNF5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNF5"/>
    <dbReference type="OrthoDB" id="70707at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="169"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="418"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="523" mass="60883" checksum="CEE60315F54EFAD1" modified="2023-09-13" version="1">MKNEIICFGRNEKPKLIKNEPYKIAKPIQFKFKFENENENENENENENEKQIKQISSGYLSIIFLFKNGKAIEYLNKNDSKQNPEKIQIENIQKVTIGDQNVAVLTIEGNVFAKGENINPNNPNELINISSLIEDKNDRVIQDVVSGRNSIYLLTSNKNAYRIGSNQYGQLELFGCGNNTNGQLGLGESRKETKIQKLTKIQNIPKGKIINIQCGYSHSIMLIENENQNQNPKRKLYSCGSYRYNGLGKYGKNAYEFTEIKSSLFENDDIIEVSVGNFHTLILTSNSKLIGFGYNYFGQLGTGNLTENELIPIQIEIPKLRFNENISNYHISCGTHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNNSNINPKLYYEIKEIINLNEKIEETMKRIYLNENENENENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIEITQEIIDEIQIGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNS2</accession>
    <name>A0A9Q0LNS2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNS2"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="160" mass="18574" checksum="1BDB88419421639B" modified="2023-09-13" version="1">MNDIFFVGFNQYPKLIKNKKWLIKKRTQFKFENENENQKQIKQISSSGRFSTIFLFENGKAIEYLNENPEKIEIENIQKVTVGFRNEAILTIEGNVFTKGEDINPKNLNEFINISSLIEDTNDRIIEDIVSGDNSIYLLTSNQNVYGIGSNEYAQLGFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNT8</accession>
    <name>A0A9Q0LNT8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA recognition motif rrm domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNT8"/>
    <dbReference type="OrthoDB" id="20442at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="353"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="503" mass="59910" checksum="9CD38752BE4D92FF" modified="2023-09-13" version="1">MSYRSRSRSNERSPKPYRGRNRRWEKEPSRCLYVGNLPFFVDEKDLEHLFLKCGELQRVMIGKDFRTGRSRGWGFVTFVDKRDAEDAYHRFQGYSFEGRRLKLDYDEGLERKSRFPPRGRGSFRSRSPPRRRSRSPPRRRRSRSPPRRSRSPPRRSRSPPRRRRSRTPSRERKPRTPSRSLSRERKSRTPSMERKPRTPSRSPSRSPVRDGSLNHNSRSPPRKSGSNTPSPQRAAPNSRSASPLNRSQSPAPRNLRTPNKKPVIDLFKNTQPKEITFPKYISKIQSFPKQVKRIKYTRSKKNFRRNFFSLLGIKPKTQTHNKSLIFNISKIQIKESTDLSQTSKENLPNYDILKDVQQKILETKKQLFDLQKDFLAFFQFFGNQMSNLKENSQIFVDKYHNQLETKDQKIEDLENEIIDCENFIQKIQKIGKNLMKKNTEQENELQKIYKFFGKNWESAIIEYNLLRDLKQEEEQEKTEFTISLKDIQTFEVQNQFIPRLFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP97</accession>
    <name>A0A9Q0LP97_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP97"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="843" mass="101452" checksum="371EC890AD24A4AF" modified="2023-09-13" version="1">MFVECESLTYFNPENNQNKTRRHKSQPFLNRRIEKFFQISETKRISKSQKFLKIVKKFNSENSNQNLNQNLNQNFNEKSENNSNSKINLQNKKHDLDKNVLNSNFQKKRKRKQRNLEKLYFIEKEKIIPNENFFHKNLFQNYNSNENLIENIDEIQEKIDKLIEIDIENENQNQNQNQNQIENGNENKNQIDIENQNQIENGNENEIENQNQNQNQIENENENEIEIENQNQNQNQNQNQNQNENQNQNQNQNQIENENENENENENDSSLYFDETYDFFRFSPSKYSEINDSFEISSTKKTSNSPHFSDLSEFGDHEFEEFSIRTSDQDEFIHYDEIKTNLNFQFQEIEEKRNKNNENENIKTKTNLISTSSLPNKESKLKQEIKIQNQIQIENQNQIQNQIEKQNQNQNENENENENQNEKQNQNQIENQNQIENQNQNQNENQNEKQNQIQNQNQNQIENQNQNQNQIQNQIEKQNQIQNQNQNQNQKQIENENQNQNQNQIENENENENQNKIENEDENQIQNQIENENQNQIQNQNQNQNQIQIQNQNNKNISIPKSNSKLKIKSQSDQIELIGEKKGKFKKSPNKFKMERSTSITDVETNSNRLQSFTQRSRSNTENVFINRKTRSGRPVPNISLQRYSRSQPFKIKRNNISKIKSAEKKQIFRSKENHKKLLEHLFDFHPINCDSYQREIRQLKKFIQETYDCSLILQSKIRDSQKLLEKYKKIYSKKQKVEELNTKELSFRFGLPSKIKLKCVTKNQEVYYFEVSRQIDIFGLYEVLSSELNKFFILKFRNHLQELQVFKQIDLARLFEDFTTGKIKFVRLYIFFSRRQKKLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ52</accession>
    <name>A0A9Q0LQ52_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Armadillo repeat-containing protein 4 armc4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ52"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 4 ARMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="240" mass="27374" checksum="91F8AE8B29F1C881" modified="2023-09-13" version="1">MTTPENRINIREDGALPFLVNSINGFKSKVYKEVIRAIRACTISSKSTDNAKYFTQYNLLSEIEKRFAIEEDYEVLSDMAIIIGNCALDEQSREKMLIHGILKKLIDLCRSSDEKVQSSSVCALANCAMSEKNQEVIRKANLFPDIVEALHSMNPYTRIGAILIIRNFARIGSDSQSENWNLNVEKFLRLGVLEKLISLFNNFDQTLNDLVSETLEFLSKNSKIQKRLQELISQEKSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ81</accession>
    <name>A0A9Q0LQ81_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ81"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040202274" evidence="1">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="19148" checksum="F4F52F6EB8F73CE1" modified="2023-09-13" version="1">MNLFSFFLFFLFLLLFPKLIYSSSEKKNCGDQIDFDIKTQIKTNLDNLKQKSKQNQILDEKIDLDSKIELELDSDSDSDSDFDFGPDIEIPSVPSLPLITIEFCGEAYILKNELQDLLYDVKLNRKYETDDCPFFNVFADNRIIFKKTIKDFFPEINEIVDSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQD5</accession>
    <name>A0A9Q0LQD5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamine-dependent NAD(+) synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQD5"/>
    <dbReference type="OMA" id="NKDEDFY"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD/GMP synthase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="363" mass="41457" checksum="D8D1A6A5822238BA" modified="2023-09-13" version="1">MLTTITQKFKTGIKRKIIEKTILNQINQRMISKLMNEINLKKEIKEIKEIKQKIFQNSFSTKKKTESKIIFSMHQELEAKLEEFRKKRNFDPETFCDKKGEMLNEYMKKFGLKACVIAISGGIDSAVCFALCMHAKKLKDSPIERVLGITLPIHSTPSHIQRAFDLGKAFDNEVVSVDQTEIHDKLSEIVEKAIGCEKPSKFARGQFRSYQRTPINYFATQILGSMGLPAIVIGTGNKDEDGYLRYFCKAGDGVVDVQLIADLHKNEVRQVAKQLGVIESIILAPPSADLWEGQTDEDEIGFSYDFVELITDFNDLSTEEQKDFRKSLGLEARQQFDKVFEKAKEIHRKNAHKVNFPVNLNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQT9</accession>
    <name>A0A9Q0LQT9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQT9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="354"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="547" mass="65106" checksum="38528763421DB0C2" modified="2023-09-13" version="1">MDNDNNNQIENQNQNENENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLNLNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNERLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKKDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIENKEKENQQMKIEIEEKWKKEVEDKNKEIENKEKEIEKMKPIFDQFQMEEISKNFPQFSDSEIVQDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFSSPKWYDICANKGKTLVIIKTKDNFIFGGFTQVGWTNDKSKWKENYRNSSTGHIIDSNAFIFSLRNDKGDRKPDKFTIKQGREEYAIRYDSSSRGPTFGGKDGGGYDFYFESNLQPGDSNFGNSYNLPNGIKEGTNEARSYLAGSYNSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQV5</accession>
    <name>A0A9Q0LQV5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="261"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1285" mass="147356" checksum="D43C96CBE8D34199" modified="2023-09-13" version="1">MNEILFFNLNENPKLIKNKSYEITKPIQFKFENENENENEKQIKQILANKFSIIFLFENGKAIEYLRYSKQNPKKIQIENIQKVTVGLQNEAILTKEGNVFAKGEYINPKNPKEFINISSLIEDKNDRIIQDIVSGRNSIYLLTSNQNVYGIGLNQFGQLGFDSEKLHKTEKPILMMKNVSKIFSGISSNSVFLLNSNQELFGSGYNFYGQLGLGKLRKATIQNLKINQNIPKGKIIDIKCGSLYSIMLIENEEENENPKRKLYSCGNHRYNGLGKNEHTYEFTEIKSSLFENENDILEFSVGFEHTLILTSNEKMIVFGYNAYGQLATVDTNNQLIPIQIELPKLRFNENISNYHISCGEFNSFLYYSPFSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQIEIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYYEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELRTRRDLQVYSEVLPEYQELIFLEQNTSMSFGNSISISKNVVVIGDESTNLVYIYRINKSNATLEQILSEPETTTFGHSVGVSNDIIVVSDYYDLRIYIYQYNGSTWNFQKSMSDSSGVFGFCVAISNGVIVVGDYSDQTVFVFRKIGSFWNFDNYFHEDLNGFGYSVSISNDVIVIGAYPAEEVYIYRYNGSNWNFEQKFFNSSIDFAFSVSVFENELAVGAISVDSVFVYKYDGESWYLEEIIQSHFGSNKKEMRRSNLISNQNQNSNQNSNQNSNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNHLENSNQSQLENQLENQLENQLENQLENQLENNLENQISIDPLTFQQFGYTVSISGDMIAIANIDTEEIQFYQFASIGWVELYTDGIFCLTDCPVTVALSGDIAAMAIADVSQAKIYGYSPPEVNVTNCTALFSSFECYWEEAEYLFSMKYYIDYGLGWQEILWPIHIEPNVSYQQFNNSFYPNISGNVNYSINFRACDTNSTLCGIISSPAEVFTRIPIVEDFNFAATNQSINVTWNPPNVPLVGEIPELDHYVVTYYQGDALGLTNYTLDNTTTSFVMDSLDCGTTYFFSIWACRDSLCQGEDQGEIFNVTLSTVFKEVYSLQCSLLYVYVISCTWFNPIDCTNNPAYYVFDYQATSGNDSGTIQVTSTSATFVAQFKSQDYDIQVTACSASSNCGLKTYSSATTATEADSNNISQVSIGFSAAFIIFGFIFLTVAFCILNKNAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR12</accession>
    <name>A0A9Q0LR12_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR12"/>
    <dbReference type="OMA" id="QQSILHY"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="379" mass="43977" checksum="5835D40623BAF303" modified="2023-09-13" version="1">MKMNLLKKSQTHQHNLNKKMKIKIEKKNENNKIKSESIPNPKSKPKSKSNSKKDENENKNQKKKNDKENDQNANPNPKNNQKDKKRKDKNQKDNQKDKNQKDENKGIEQKSNEDKDNEKNSNPTNSKSKSKSKSKQSKSKKEKENEKKKENKEIESKQNQKSKEKKEDEQNGNLNNESNSKSKSNSKSNSNSKSNSNSKKEKEIEEIEVEKKGNESNNSDSKSKQNSNLKKEKKSKKKKENEKKNEKKNEKNKIKSESIPNSKPKPNSKSNSKSNSKKDENENKNQKKKNDKENDQNANPNTKNNQNDENKKDKKKKDENKNDENKKDKNKKIEQKSKENQDDEKYSNSQIVSKPESKSKSKSKSKSKSKSKSKSKSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRS3</accession>
    <name>A0A9Q0LRS3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRS3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="391"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="576" mass="68381" checksum="1592DF4AB2217759" modified="2023-09-13" version="1">MNLWDDKHQKPFKEFADLKIIINKEIFYCHKYLIYQNGCENFAQFLQSKKFRKNLKEKEKENLKEQIVAILRFIYKRFEESIPLKDAKLILDFFIKFPDQVLISILIPLWQTFIESTIIKSSENSTNNSMIIYGKNSNLFDEDLILLIKSFDLICRTDDLLSDLKEIEYKKYRNFINLMRNNFQTFIELQIEVFYDLSMQSLQELFANDVLLCDKLNYLIKWANHQNQLENQNQNQNQNQNQNQNENQTENQIENQNQNQNIKKKKKDSNIFEKQDENIRNLVTKILYKFEPHDEVELIRYRSNYHLMKILISETGKLLSSNNFKKKQSRHSILKEIWSMIPSEKIKQDNINYEYLQQGLSWVVFPLKSNILVEQALLEVFQESKGNQNQKFPRINYIEYLKKWINNEEFFKNVELVFEKKGKNSSANFHKACDKRGETLVLIQTIFDNRRAIFGGFSKVGWNPEKYGTKQYIPDPNAFIFSLLNPLDLPPQKFKVDPTRSSFALQYNEKCGPIFGGGIGGSDIAILDDLEKGFSFFGTAYKTVKNFYYPIQTQNYFAGCFDKFRVQKLEVFCKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS90</accession>
    <name>A0A9Q0LS90_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sys1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_05445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS90"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5077755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="280" mass="33171" checksum="F184C4F0A570E7BC" modified="2023-09-13" version="1">MWYLFFVFGAFYLFLIILNLRKEKKSRHSFILEISPIRVIFEIIFLQFAFYAELVFVIAAFNLFNSEIFFFSQLFDAEEYQFRTARGLITTFSLVATGIFHSFTFTTVLHFSWKMDDFGLTWFFIHFIIVSARTGEFPQTGAWWFSCLISIVIMILLSEQMSLTFNSMSYSLPESQVKPVKKPSSNKNNSNEIKNEIKNEIKNENKNEIKNENNSNENKNEIELKTEDNDFFDDDSFQEFDLNFEEKNNQIEKKDNSLNFRDFVEINLDKTTPSDQNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTH7</accession>
    <name>A0A9Q0LTH7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorting nexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTH7"/>
    <dbReference type="OMA" id="KANERKF"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="133"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="58443" checksum="3AD40F05BB6D4EC3" modified="2023-09-13" version="1">MDEIYANVLYEYSPQAKDELPLRVGEVIRVVSQDPSGWWEGESNGLVGLFPSTYVMIISNDINNENQDPQELNITNEQEVTKESNEQIKEDHLDPNINANQDLQIEINQKIDHVLEKKYLIENSCWKETPIEANVDIGESTKILKYKGMKKFIVYEIKFKNYCVQRRYKHFLWLRDHLHEYYTDILIPPLPEKQISGRFHEEFIGKRKKGLQFFLQKIMEHPVLRTSWILEHFLSSENAKDWKNGKKMIQNQLKSHKTFLECVEISQINPEKIYHNFVENHNFKEEIQLTQQNMKNLHTNTVELFIQKLSDLSKSYSQLGTAFVALSENEGHGLSWKIEDYLSQNIEKISKLIGETFTKASPFLVSSYSKINGILEIIAGYQRFYSSIQDNIKITDSIIRHYKFPQQKKHSTKRDNSDTHELNHDEQREIFQSDMFMNKDLIVCDSELEQFHHNRLIDFSKILEEFLKIQLEFHEKMTEFWENTLLAINQNIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2024-05-29" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTJ3</accession>
    <name>A0A9Q0LTJ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Growth protein (Boi2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000045">
        <property type="protein sequence ID" value="KAJ5078752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="124"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="439"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5078752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1420" mass="169551" checksum="6FFB153A04A75878" modified="2023-09-13" version="1">MILNINQKAIARFNYASTDPKVLFFNENDEIIINEQINKKWVKGKLVKNNIEGIFPLNYVKLQNPIDPKLDPKLKYQKNFNQETMEIFLTDLNPETSYLESALIKKQTVPLIKLYKPTRLPLFPFSRKGWLMIGSSNGKWKKKYCVLENLSLRYFPSEKENENEMKSIYIDKIMCVIRDSFQKTEKNSDSKTKANSNQKSKSKSKSKSNNKNDENFTFRIITKNQKNYHFQANSKKEMDDWINIICLFHDLLKFCSYSSTTEDIPTLKSLIQLMEIVYRRILEIKSKNNDQENEEIQTTSKTIELWMNLLLFKYYLVLKDKFNGESYAISIRDQESEAQHDLELRKYDYLKILFAKQEEKWIGKGEKSDGYFTQESIALLAFDSNQENGQKSDDKFDDEPLFFEGKETRNFVSNDLPEGFLINKALSILNYETKTNEFVIQKNGILCYETTQGWKKKYLILNNFYLNIYASDKEKNPEQTILLDKTTKIEKLQPKDKKNIFAISTKEYAIFKFYSTNLFVIQEWIQMIQISIYLLNIYEPINSENREIESKIHEIEELLKWIQESILNSEILISSLRKMENVGFFQNVSRRLSSSRKNEKNTILQDFQNQPFLQRPRQKIRKERSLLSTTSKNQTEEERRKTIENLLDLVDDEIAKEQNEESNSPQKNILKPGIVRLNTDKKVTKRNIYELERYRRRIPKTPTKNINDVSYYRNIRISSLFLEISLFKKIKRKLVKILGRLKFPNLSNDAFIGFTLSNTKIEPSNSSSHLNQKNILKHDIVKKQVLKKEIAKPQEIKKDEWFQIEIENENENQESRFLNIKYQNEIWQIEKSKVMNFKIESDFNVFKIDNNNNLSNSQDNETIQLKIDILELEKLKLTQKEAISPHSPLSKRVAPVRFTYSFLSDLETNSRSRIYSFNLNNLPRKKSIQLSHYYFEKWKQINLNDEQQFPIYCSDSLLFLSNKKWITRWIMLNNWILSVNKSNYSPKPEKIYDLRDIISIKKEKSLFGQNNVLTIQMPDIIISLASEDILKNRSWVDQISALFNFIRFIASENNERKEEVDIIIYRLKSLLDWIQQQLKNYQKEKEEHETMIQLYKEIDSQTTFSFEKRIEICDYKTNHLIHWRKKILKRLLDTKLPERNRINFYGYIWKNFPQKLMKQKLDEKIITNYEKGDWIILNINNEKTKKFDLNELIHSDQEFIEGMIIRTKEKGSIFKKHVHLVEEIEVKKEEQKNEDDIFQIIPETKDRKEKEKEMAFDTESINEKEPPVHKTGAVYLSRSRLKLSSRWKIRSIEINGYNLNICHIDTNKQKILFAFSAEEEQKDWLQNFQILNYFLFLSNIVVEYNYTVSNNTDNKDGNHIHQNRNENLESIKKMYHNVEQRKELLYKSAFQNRHFTPFKQGQLRQFLNKRRKSWIYYSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTU5</accession>
    <name>A0A9Q0LTU5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myb-like protein x</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTU5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21218">
        <property type="entry name" value="CH_PLS_FIM_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="762"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="866" mass="102817" checksum="429E8A1F59369760" modified="2023-09-13" version="1">MSSNLSLEARALLYRVRYHPSAQLFSSKEDKNLSPKQVLINWVNFHLTKSLNRKIENFGSDLHDSICLSYLLKETLQGNANFLEVLQLKEIKERANKLIELISQTTYSRFICTPDDIVNGNEDEIIKFICNIFLWSSNSQLSSKDKELPNNIQDLIQKAKSRKKQNPKNEDSKNQISTVIDRFKEQKNQPKNTKQLKNENQSKNTKENSVPKRKSKKKPNLKIETETQKTGYISQLLEKMNMKFPRTNPVSPKSANLEIHKFRNAFMFPKTQKITKKKPVSNQIQQVYEKIKNEEKIIVDLEKKTEELESQIEKEKKEKKNKKKKKVKNQTFYKQNLLETPKFAVLDNIQMLVSFEKDHNQLFEEMQKFIQNGNETIKKFSNMLQFSEKYSDLQNVDLHFGFINSEKDENFRPSKLSLQLIHTIQYILLHYEMSLISKNDVTDFYQEIELQINNIPNFNFEDLWKKIFIVIIEENELKSENDENILRAIHIAFVIYNFLVIFFSELSSQILANQNVMKLLSSKLDSLKLHKLIFKKFLNLVHQDFMVSQIIDFINDFMKNLFIPNLEETVKSIFENAKKYALEKMMENPINTITETLDNKKEIKQQIISSNFFEKIINCQKSEEFSMNNFDKISNSFDNTEYFESPIFIYSLFLDNIKNTKRNKQKKISLKFFSEIQTMFRGFENDFLSESGSFRAKDFLEKICLKRKEIEFLKNSVEEFNNKYLPIEKKVELVYQAYSNIEQNEENQLEFSEIQKIIAKKRIKKQGYLYFGKGENNQNFQKRFVQIQGDYLFIFEKEPSLLPTKTEPIDFVYLKKIIQIDFQSRYSDKISIFSIILQKSIDEVDLYHFICEKNEFEDWVRQLEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTW5</accession>
    <name>A0A9Q0LTW5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_05525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTW5"/>
    <dbReference type="OMA" id="MANAVNW"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="183"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="487" mass="56994" checksum="7638A64C7479FDCE" modified="2023-09-13" version="1">MMNNWNVDTVIALELISKKFKNQKIRQFGVEKLDECEDKELILYLLQVVQGLRYEESEKSPLTQFLIRRSLQNPILGVYFYWYVGTERNDKKFSIFAKVHLEFARQCLESEKGKVLLTQLQRQEKLIQELGEIAEKLKSNSKLSRPKKITFLKEMLQFQYKDLLEFQPLLLPLDPHVSVIGIKPENVYIFKSNLYPMKIVFREFDSHSFKFKENYKGNDKENEKENDKENEYGIIYKMGDDIRQDNLVMQLIILMEQLLKKENLDLKLTPYHVLPTSSEIGIVQFVKAKSLASILGEFDSLSNFFIKFHPDNNNDFGFEKDVMSNYIKSCAGYCIITYILGVGDRHLDNLMLTQDGKLIHIDFGYILGHDPKPFPPPMKLCKEMVDVMGGLKSEYYQEFKRLSAETFIALRRHSHLIVNLLMLMIDANIPDIDRSQTSIVKVHEKFSLHLNDEKAKKYISAVIDESVNALFPQVVETIHKWAQYWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU25</accession>
    <name>A0A9Q0LU25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron carrier/ protein disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000050">
        <property type="protein sequence ID" value="KAJ5078685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU25"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="391"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="814" mass="94860" checksum="5E87B6338D3B6020" modified="2023-09-13" version="1">MKTNKQYFYKLKGKFATLLQQKQNIIRVQSTNQDLKKKIEQVQNKLKETTNKTNFLRLELKKLEEKINQKTTISISNSISNSNLNSNLNPISISISHSNSVPNNISNFHSNLTSTLHSTVKKLESHVSFLQVISLSNKQINDQLSQEELNNVIQNLTSFLIKNNSHQQQLNSLKKSIGFFYKEREQKNKILIQFLHNEKNNLLKILNKLLFEKEQRDLISESNTYLSMQERKTALRLQIAEKNNENRALMSEYQYLKERSIHEYTSSTDNNITDGFDSNNPNDSNLTGNEDRVSEMSDSYDSEVIAIGFDDSNLLNNTIDRNLNSSPLSIHENEHLKEFTVFDNPNSDSSKLSKRQSVLAIRIPSFQEIQENGISQIKPKINEESSINFSTLQDVLQNSYAVEFFKEYLTQQYNQENLMFYLEVNEFKKIKEENIENLAKNIYEKFVKNESLFEINIDSQTRNEISNKVEQNDFSLNMFDEAQKIIFILMDQNSYDGFKNSDLYEDLLKKLKYLSKNGSSSIKNAKLIFHSSKNIVLNIGNKFEGKARDPNSLSELLIQILIDFCNYFFLVSNSKIEIDSLSNSIPFRRFVVLTSELQNVNLDEITSVSKRKAFFLNIYNCLYLHAIIVKGIPKDKSSKKKFQNENKYNIQGMEFSLNDILNGILRGNHDKKLKEKQYFKQNDKRIKYTINLDPFIHFGIRSFDDSGIPLRVFYKENSDKELKNMTKSYISEQIEIDEQKSQILIPHLFQEFSKDFGSNIEETFSVLSIFLTNTHPNFDSNFKKFHVKFKNPPKSSLIFDSKYTSFEEENLQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU64</accession>
    <name>A0A9Q0LU64_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000046">
        <property type="protein sequence ID" value="KAJ5078736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU64"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="100" mass="11624" checksum="CAB1CA8A4613062D" modified="2023-09-13" version="1">MTLNNFDLILPSALISNSPSNYILMILFWIVDILSLLSLFQSLRFDQKKSGNIYRSILLFSSVLMMFFLGLFSLIKSGRNINFVGFFFIVYLQSFLQFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUX6</accession>
    <name>A0A9Q0LUX6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUX6"/>
    <dbReference type="OMA" id="GWWMSFL"/>
    <dbReference type="OrthoDB" id="5273684at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF4">
        <property type="entry name" value="N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="417" mass="47586" checksum="52427E83982CCC46" modified="2023-09-13" version="1">MNSNQKENQNLSSTDSESQEEIEIDSDDKIIITEEDETKILNESQNFDNQVHEKLHKYFSLQLKEEKKEKENEDEDDEKENDPYAIPRFIINLDEPPETRWHEVVEKYKSCYKEVLEFLDGMIKEIFGSGLIGKFMKKIANSIFGSIAKSGAVFFGKELQAIAKQSKFPLGSLLLLNIAYELSAACTSIVTQRSDDNKFVLARTMDWEMPFLKKFTIEIDFRRNGETVFIGTTWPGYAGILTGMKPGVAAVSVNYRVTGGSVLKNLMTAKDGAWPVGFLVRHLLTSDYSYDEIVGGLSKSFLMAPVYLTVCGVSDATLITREREDEVKKSRWTFSKKGLIIQCNQDHWRNDSDSDVFMSRKRKKAAKKILAEMEEKDLINNDTLWALLYTPPLTNDITIYYTVCCPDDGYYKSRIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWK0</accession>
    <name>A0A9Q0LWK0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_14533</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000034">
        <property type="protein sequence ID" value="KAJ5079200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWK0"/>
    <dbReference type="OMA" id="QFQISWI"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5079200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="184" mass="21833" checksum="3323A9BD5F36B287" modified="2023-09-13" version="1">MQRKLPSGNNFEAIKKIGKGSYGSVYLGKSLKTKENCAIKRIDLRKTRNLENARKKVNRELEVMKRVKHENCVELFFIEPKNYQNADLIYVVMEYCDKGDLSEYLDSKKEKNKKLSIEEIKGIFRQIVLGLKYLHQKRIVHRDLKPKNIILQSNQNQSNPPYFHIQFQISWILDFQKRNSQKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWK1</accession>
    <name>A0A9Q0LWK1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWK1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="132" mass="14454" checksum="00C7C9A07F052BF6" modified="2023-09-13" version="1">MIEQIIPLAAHVANGFGFFFAIGALGSFEKQTQKTLGLWFVTTFFVLGISVVTFLLQILRRFGHRGKIFVAGFSVLGSILLLEGINAIYTGYCIGPTLYPGGECMNKSRTYTAGSLFQLGGMLVLIFFCSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWT5</accession>
    <name>A0A9Q0LWT5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Guanidine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWT5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="116" mass="13483" checksum="75D41DEC76FE7B4F" modified="2023-09-13" version="1">MAKTISINQKNQIIFFGENEKPKLIKNEPNEIINPIQFEFENENENENEKQIKQISTVSVGYYNEAILTIEGNVFAKGDEINPNNPKEFINISSLIEDKNDRIIEDIFVELVQFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX75</accession>
    <name>A0A9Q0LX75_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-lymphocyte activation antigen cd86</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000028">
        <property type="protein sequence ID" value="KAJ5079545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX75"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040269685" evidence="2">
        <location>
            <begin position="23"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="887" mass="102307" checksum="C367C0BB98630CF0" modified="2023-09-13" version="1">MKKKLVLICFCFCFCFFLISSAQNQVILKNSFYLPNGITNPVLSLFDEMNNVVYFINIGMDLNLNPKSEIYKFNSTNLEFLESTNLGNRITTGIIDELHQMIYFGAVQHQDESNFPQIIQFDLLSFSINNCLNFTSFPNLEFVDSQVDVFHSKGYFILSCFFLHYPHIFKIDLQNFEFDSNATIYSYSNILGSAIDILNQNIYIFSHNKEVVSTMEIQKFHLTNLSKTGTLFLDEHAIMLESIYADIDSSRNLMYAAMVSTASSFLIVKVNLDDFSVDDHLILQSTNYWGFSGGGIDELNQLGYFMIYGNCSIYQIDLSTFRYIQEFSFSNGFSAVSFDSQTTHAYIGFYNSTTIDFDLLKFEVDQSRFVQNFQDPSVILIDEPKEMSYIGFGSGFGLVARIDISSFQLISHLTTGNSSDQINFGEIDSSGGFAYFFINCTTSSQSIPKIMKVELSTFSISENKMIDSNGSIEATSFDIQNHFLYVGYLNFSDQNGAILKINSSDLEIYGYFFISDLRQFQKLFLDSSTKILYSFLYVNNSIGFWLDLIKIDLESFSQISHLDLTNYYPINGTVFDSIHQYIFFQSPYQRIKTKICRIHLIEMEVFDDCLLVDQDEWNFQHSFLDSTQTYAFFLLNHPSNMHSSYLIQITANPFQILNQTHWDYPFNISALDFSKNYLYSTNLVDFGGNAKEMVLFYQISLPNPTPIPNTSNQKSSKSIIIILSTIIPILIIISLIVIFLILKKKIKKKKKIIERKESKKYQKIKKSSKCSLFFKPILKWIGKPNFLDFVGDDVIWRSLTVILLSTFFIFTFGVAIRYLLESTKINEDKIGINLNFFKFPNETELYYFQTFSTELRVSKKYKSDGVKNCKVNVSAYSLDSSRKLWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXH6</accession>
    <name>A0A9Q0LXH6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXH6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="149" mass="17306" checksum="B37132FD91B01784" modified="2023-09-13" version="1">MSLLSEEDQKSIVIWFRQLLQLEITPPITETQFLGYTWMVLNKVSSKRVPFIDFDKGICSFNVARINEICANLRIPRQYQLPNDPVIQDLHLLILYIAALAQQKQLEPKLQLSSTLYEQIVRTLSVPIKHPRKIHAPTSIKFKNISQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXU3</accession>
    <name>A0A9Q0LXU3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_13781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000002">
        <property type="protein sequence ID" value="KAJ5080740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXU3"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5080740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="173" mass="19877" checksum="372C4B348FC58137" modified="2023-09-13" version="1">MSRSQKKIDKINFEIFTLTYGEIVTTLLKDYEDVEEVNNQLDKMGYSMGIRMVDEFLAFTGLNKCSDFRDTADAIANKAFPLFLGFPAGIQNFDEKKKEFSLVLDQNPLIEFVELPPKYKGLFYCNILCGIIRGSLEMLQIDVEAKYKKCVLRGDERSEIFISLKQDPKKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZ62</accession>
    <name>A0A9Q0LZ62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine-protein kinase ulk3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_14180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000014">
        <property type="protein sequence ID" value="KAJ5080093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZ62"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="300"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5080093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="591" mass="69182" checksum="E225D4E2ED2E1468" modified="2023-09-13" version="1">MEKKIIFEGNNFIATQLIGEGGFGKVYLGETKDTNQICAIKKIKLSKNRKMTSRELKMMEEVKHENCVQLFFIEPKDYQNADSVYIIMEYCDMGNLNEYLKSKKDKNEKLFIEEAKEIFGQIVRGLKYLYEKGIVHRSLKPQDILLQSNNNSKFGYTIKLADFGFARKIQRDDSGKTIMMNSIVGTPLYIAPEILFNNSYTSNVDLWSLGAILYEIITGNPPFQAKSLGDLERQYNNTIKKSLPKEYIEIFGKECNDLIEKLLTVDPNSRITREELYKHPFISKKLNELKEKSIEIADLEKKIIGIAKEDFESKENGKFSFKKGDVIEIIKINKNKGICEGKLKEKEGIIELKRIDLYEEIEDIYSINELNNNNDNQLINFEKRIIGIVSNEYKTNEISLSKGDLIEINNINDNNYCIIQFGNQKYEIPFFFFDFYKQIGEKQKQKQKQNPKKIIGIAKEDFESKENGKFSFKKEEIIEIIEIYKNKGICEGKLKEKEGIIELKRIDLYEEIEYIYSINESNNNNDNQTNNLEKRTIGIVKFEYKTNEISLSKEDLVGIININEDDIYCMIQFRNQKYEIPFFFFDFYKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R406</accession>
    <name>A0A9Q0R406_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tomosyn isoform c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R406"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="633"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="694" mass="80558" checksum="4B245DBA8EAF8AA9" modified="2023-09-13" version="1">MKQFSKIQIIQSTQKKDDLISFSGFFSSPWLNEIQTPDALILLYKSGKTTFYIENSSKNQNISFMEIPYHFRGKISPILAMKVYYQISETFLVSLSLSWMGSRNKNESFWPFNGGDFSNHYESKPSTVIITAHQDSFIRFWDASTFALLFICECDILKYLEEKNIPKPLDSTIFDFIFEPNSEHLFVSFKKEKKEDKKEDKKGDKPNSPRRKPLVLQKEEKNWKKENPKKEESKKEENQNQNPKKENEKENPKQEESKKENKKEENQNEKAEKSNYYITQLFKIHKTNLNQMKVLVVDENQLLITSDISGNVCVVSISKESPVIHFKNYGENKISFIQLFQVPIGKKKEIKQVNIAFIGFENGKIQLLDVSSGELIDLNVLNKLNINQKIIKVFLLNEFGSEIEKIEIIKDVKIPEIPAYYYLICFEKTIFLINSKLENVGKIEFEEIITQASILNISGNLKQNQKQNLDELLNQNNPNQNIKNGLILFTYSEKNHLIQNIKMISLLKLDEVFSINLKQSLEIPQKAFNDSLFDFLKDGRIFWVTKSSEFGQSSLLKNENYLSIPESLPSLYSTSIQVKQPKKLPNSTLKSKNKKVTLTEFYKSFGEKQYTQKKPQKEETFSSSLFQNDSTLKPIDDKIDGNDALGQISQARDKLLERGEKIENLEIRSNQLTNNSSEFLSNIRQLTQKKKGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R428</accession>
    <name>A0A9Q0R428_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R428"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="240" mass="28827" checksum="69560AE4E9513D25" modified="2023-09-13" version="1">MTEEEKQNSENQTTISKNLQFFENFQQKPTELQKKIQKPTFAIIQLRKQNKQLQEEVSNLEKEIENYQSQKKEKNEENVLNINNINNNDNNQVYEELKKKKNQLEIEQKTLNSNIEDYNLKIKNIKKENHQLEKQKKNNSKKKEDEKKEIEKLKKEKKEKLEKIKELESINLSKSSEFEKQIEILSKQENESILEQKQIQKQDSSKLKEKNDELILQNIQLQAKLEILKEKIQETEDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R565</accession>
    <name>A0A9Q0R565_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rac-like gtp-binding protein arac9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R565"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5067689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="189" mass="21046" checksum="DFA9B11F45ED36D8" modified="2023-09-13" version="1">MTKEIKCVVVGDGAVGKTCALMTYSQNKFPDSYVPTIFENYTCDVPINEEIIRFSLWDTAGQEELKNIRVLSYDGADVIMMLYSTVSKTSLENVQTLWVPEVRSQTPKTPIILVGTKLDLKNDFNYSKEHAEEIISAKEGEEISKKIGAVGFIETSAKTTQNIKSAFDLALRTVLGEIKPKKKKGCILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6A7</accession>
    <name>A0A9Q0R6A7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone H3 methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6A7"/>
    <dbReference type="OMA" id="YKFRIRI"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="737" mass="89076" checksum="446BE4E80A7685DF" modified="2023-09-13" version="1">MNPIQNQNQNQIQNQFINQNQFINQNQNQNQNQNQNQNQNQFINPNQNQNQFINQNQNQFINQNQNQFINTNQNQFINQNPLMQFNSFVQSTNLQPFGNFSQIQSISFSDFVSAPENEENQIENSFEIENKNQNQIQNENQNKNKNQLENQNQNEFQNQNKIENSFEIENNLEEKNFKKTKFKKANEPFDWKSIEVVESLFESHEIENENQNQNQNQNQIQIQNQNENQNINQNQNQNQNQNQNQNQNQNQNQNQNQIENENQNENHNENENQNENENQLENQNQNQIQIQNQNQNQIENQNQNENENKNQIQIQNQNQNQNQNQNQNQNQIENENQNQNQNQIQNENHNENENQNQNQNENQNQNINQIQNQIQNQIQNQIQNQNQNKLENQNKLENQNKLENQNKLENQNKLENQNIEKEKIKKLSLIELAQELQNIPSFSKEFEQCQKIIQIQKQMRFLKLKYQEAKENDQLEIAIQLREKLQNFQNQTEKIQNQIFHLKRKLFIYRIEKSKENQINSKNTQENENENENENEDENEKSKKSKKTIYYGKFLYERNEKKQFWNKIQFKIIQTLETFLKNFHKLINSPDLKESPNFAEEQLKLVFESEKVRKHISYLFVLCKFFKVVDDIHKFYHGNYESSSIQNLINRFRTRFFQFKSILKEHNVIPDEIPDEDNIDQISINNWVVAKQLVQNNIDYEICSLCCLPILPKTPSFFDKENHSFHLFCANFWNYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6L4</accession>
    <name>A0A9Q0R6L4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6L4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="228" mass="27429" checksum="6EFC566546698133" modified="2023-09-13" version="1">MALRFRETFNEIEKIILQNQNSSFNILDLHKNIEELLNQIENIFNDSQQEIEMLKTLQKNNQKLINQKKSITNLIQKENQKNKNLKSSLFKLEQNLEKILNQNFLFKKNEEENAKKLNQIFNSLSITKSKKQKELDSINQEINQIQQIEIDLKNHLKILNQELEKIQKEKFTNKIKLSKKEKEIAIKINQIEKEKIMNEKEIQNLKEILKNDKLKKYLEEKEIERKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7W0</accession>
    <name>A0A9Q0R7W0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7W0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="247"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="439"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="538"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="643" mass="75424" checksum="D63DD4FF05315E28" modified="2023-09-13" version="1">MNDCLFFGWNKYPKHIENEQDSIIKPIQIKIQFKNQNKNQNQNQNQNQNQNQNQIENGILKPIKMKFEKEKEKEKEIQIIKQKEKEKEIQIIKQNENENENEIENENENENENEKQIKQISTSFFSTIFLFKNGKAIEYLNDSKQNPSKIQIENIQKVTVGFENEAILTKEGNVFAKGRDINPKNPKEFINISSLIEDKNDRIIQDIVCSRFSIYLLTSNNNVYGIGSNESSQLGSNYIFFLLNSNQELFGCGNNQYGKLGLGKSKRKKLKIKKLTKIQNIPKGKIIDIQCGAAFSIMLVENENQNPKRKLYSCGGWEDNGLGKDEDEDTYEFTEIKKSLFENDDNILDFSVGINHTLILTSNSKLIGFGYNYYGQLGTGDTNDQSIPIQIKLPKLRFNEDISNYHFSCGFNKSFIYYSPPFSNLEEDLIKLFKRKEFCDISFKTENGEIIEAHKLILKYRLNQNENQNQNQNEIEKLQEIISSKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKKIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQLFEYWIYSNQIKDEIEITQEIIDELETGIDYFQLNQTNPNLFDLLINKFKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R936</accession>
    <name>A0A9Q0R936_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R936"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="233" mass="27496" checksum="5803E86E6AFBC7E9" modified="2023-09-13" version="1">MSTTKTQKKTKSKKQKKLATRKKRIETFKRNRWYMGFSLCEEKKSKKKDKKTDEVVNSNELKVRFREQEFRVRLAIIEAPEKTSEDHKKYKRGIKRLLKGSFSVFVRNVNDNNIPNVDIIHGSGTHPKRPWDSPNRWLQATLLKAQIVKRAPDNNTESQRVIDIHLSKFKKNQEKKKRKEQNDLQEQEKKRKKNLKNSNSNLDSDNSLSESDSQSESESEKEKEKGKGKRKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB21</accession>
    <name>A0A9Q0RB21_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB21"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="352"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="457" mass="53505" checksum="562DF88B93AEFCBA" modified="2023-09-13" version="1">MNEIIFFVIVGWQNEAILTIEGNAFAKGRNANPKNPNKFINISSLIEDPNDRIIQDIISGDSSFYLLSSNQNAYGIGDNHFSQIAFKSNNKKKRKSEKPILMMKNVSKIFSGNCSHVFLLNSNQELFGCEKFIHVVILGYNGLGKGDKYTNKFTEIKSSLFENDDNILEISVGYNHTLILTSNSKLIGFGNNYYFQLGTEDIKNQSIPIQIELPKLRFNEDISNYHVSCGYSNSFLYYSSPSFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYFEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIEELERGIDYFQLNQTNPNLLDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBJ8</accession>
    <name>A0A9Q0RBJ8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBJ8"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000661">
        <property type="entry name" value="Cell differentiation family, Rcd1-like containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000180">
        <property type="entry name" value="serine/threonine-protein kinase STY46-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="593"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="418"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="498"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5074187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1116" mass="126925" checksum="6050F43F542BBB9E" modified="2023-09-13" version="1">MSIFKFVQQGELEKFKLKKQLKGGTKKKLKLINWIPFRLEIINFLLQSGAEPNIQNGSTPLHFACLYKSPIEVIQTLVISGANINSKDQNTPFHLACTNVPKFQTSDSFFNVSKLRNTGTPLSSDLFYVPSKELIEGLIGLKAEINAQNLTTPLHLACINKTEESIIKILIDSGADPNLMNNSTPLHYACQPPFIFSVVKFLLSSGAKVNIQDGNTPFHLACHQLTKDILQEFIQNGVDLNAKNFSDAPLHIVCKKKPSFEIGKIFLDSGALVDITDGNTPLHISCRYHADIKIIQLLLDSGSDVQKIDKDTPLHVAAIYQAEAPIVKLLIEKSLDVNAKDRVNINLDLICKMKYLFVIFDYLIKMIRMEIQLYIMHVNLIHFLMLLNYYYHLELIHKSEINKIKVHLILRMKKRKILENFKKEDKKLSKKFEELQDQLKRQEELLRNQQEKEKEDKHKSLEKLEQKIIQLESMFSGKNSSVNENTSVNENTEQSEKIKTLEGKIKYQENIINELKKELELNKTRLKIQVEKTRQKEDEVKRLSTSLEKKNEDSDVEKDGSFLLSRNNSTFSENSQMNDIMGFLSKEIGFDEIEFGDLIAKGSFKEVYKGQWLGLDVAIMKLMCSGNLSNDEYDNFQMELRILSQLSHPNIVQFLGACTKPPNLLMVVEFCDGGTLYDYLHSNAEIDDSKKIELALGICRGIYYLHSHKIIHRDLKSPNILLDRNGVVKITDFGLSKTIDAARTHLNTMVGTFSWMAPEVMFGEKYKGSVDIYSFAIILWEIQTRKIPFQNVPFGQITMKVAIQNERPPLSENGIFNDIIKDCWAKDPNSRPSIKENKGNNGQQQFTSRDVQLLVVDFLKNESEEALNELSKKRDKLPDLAPILWHSVGVIAKLMKEIVSIYPLLDPPALTASMSNKVCSVIALFQTIASHPETKPLLYQAQIPLFLYPFLTTTSPNRPFEYLRLASLGVIGALVKNDNSEIIQFLLQTHMISHCIRIMGIGSELSKIVSTYIVQKILDDNNGLKSICELKENSPESVEAICDALGKMVDTLADQPSIRLLKHIIRCYLRFAENESGKERLKSLLPLPLKNNTFSDLIKDDSSVINLLKALQDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBL1</accession>
    <name>A0A9Q0RBL1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylhydrolase ARH1</fullName>
            <ecNumber evidence="4">3.2.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP-ribose-L-arginine cleaving enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylarginine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_08500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.19" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBL1"/>
    <dbReference type="OMA" id="RKWEFLQ"/>
    <dbReference type="OrthoDB" id="10250509at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003875">
        <property type="term" value="F:ADP-ribosylarginine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF26">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="377" mass="42271" checksum="F70A32D7EC0B3054" modified="2023-09-13" version="1">MEKFKASMLLGGVGDSMGYHDKEYEFQYCGKLIHEDVNKITNGKGISALHLKGSSWKVSDDTVMMIATAESLLDSVEKGFLVVDPQNPKIDLPKVMGIFARKYVDCMNDMDNRMPGASVTGALLKIKDNPEEKWNSTPFRTLGGGCGAAMRSMPIGLLFHDYENPQILDLLISVSIESGRITHHHPVGYLGGLVSALYISFALHNLPIVEWGKKLLQIIKEKVPDYLEKAQRFAKENIDAVSTFIDHWEKYLKLRQIFGTDQNVPIFPDVYDIQERDDFYKSISFKGWGGSSGHDSVIIAYDALLGSKVNWEELCLRGVLHGGDSDSTGVIACSTYGALKGFKEVPELNYKDLEYHDRLIDLGEKLFKISNYEEKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBS0</accession>
    <name>A0A9Q0RBS0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBS0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="388"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="575" mass="69155" checksum="F11B081B17779430" modified="2023-09-13" version="1">MDNNNNNQIENQNENQNENQNENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNEFLKGENHVNSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIKKRNKSLKLRKYEHKMNEKKRLFHSFFSLFDKDSISKQDFDKLKQFDIFLPKHLLINLERTIFEIQDQEKEKKIKEKEKENQKLKSKTEKQNQWNQKLKSENDKQKQENEKKDKILKQKDEEIQNLKLSFEKENEKENEKENEKENQNQNQNQNKLMKIFSNSKIIKDIEYVKKLKEWINDNKFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKDNFIFGGFTKVGFTNDKSKWRKKDRNYDWGYIPDSNAFIFSLRNDKGDRKPEKFTIKKGKEEYAIYYNLNSGPFFGSDIELNYKLQSGESNFGESYNLPNEIEYDTKEAQSYLAGSFDKWVVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC17</accession>
    <name>A0A9Q0RC17_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">snRNA-activating protein complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC17"/>
    <dbReference type="OrthoDB" id="46583at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="404" mass="48387" checksum="47950490EC90F143" modified="2023-09-13" version="1">MNKERIQQIENQKNTIKQLKSTSFEKLSRRLSPQFNSKEFINDYKKKMKMIRDLEKTIPQEMLQWEIQFQSNLESLSPMTEFDYVEAALQKELDELKKTDITNLTKKDRIQKIQELIAKDMPHLSSLKNQDNSLTFPMREEENTNQEIIISENSEKNEINENQQIEDTDELDDPITIFTVDVYDIDHRNELDLTQTIELLGNQYLTTLKDFIECATEHIIEDLEKEKVEIMPNIPINKENFKSGYFFINNTFYNDLREEVNIDYSRQIIEWSKQNKRFLERDFYNFDSKKMEETKFNDLVFRINEPYIFTHYGDCTHVIVFTLVRIKHENDPPNENFPLKTYPIKKKKNCVFCKKRLATKIVVNDQLCPSNQALFCDDCFEKLHYSENGDLLYSDFEVYPYYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCH7</accession>
    <name>A0A9Q0RCH7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCH7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="152" mass="17815" checksum="6297C5866719D4A6" modified="2023-09-13" version="1">MVSKKSNSKITCSLSTDLEFNCAYPKDDHSSEDDRMKISGSFFLYHLTYNCDPDYDDFANFYFNDFANFYSVYYPENVDPISNVQLSNIVQVPNSQEKISDLDQDPNSIRDQDQDQDQDKDKDKDKDQDSNYDYDYDNESTCLSDSECFKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCN2</accession>
    <name>A0A9Q0RCN2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_08162</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCN2"/>
    <dbReference type="OMA" id="NPMKELK"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10 14" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="12">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="13">
        <location>
            <begin position="83"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5073889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="22385" checksum="738289318707994A" modified="2023-09-13" version="1">MSDKEKKPIEQDQDNQEIEKEQEETHPMKKVRIEKLCLNIGVGESGDRLTRAAKVLEQLTDQTPVLSKSRLTIRGFGIRRNEKIACHVTVRGKKAEEILEKGLKVKEFELNKKCFTDQGSFGFGVDEHIDLGLRYDPTIGIYGMDFFVVLERPGKRVKNRKRRKNKMGNKQKVTRNDAIKWFQTKYEGFVIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDI0</accession>
    <name>A0A9Q0RDI0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-actinin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="VYRINTH"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="244"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="358"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="820"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1290" mass="154270" checksum="548A3B3D607F4A2B" modified="2023-09-13" version="1">MKMKKNKNQNENENENENQNELNQNGNENENENQNQNQNGNENENENENQNENQNQNQNQNQNENENQNENQNQNQNQNQNQNENETENQNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNENQNQNQNKNQNQNQNQNENENENENQNKNQNENQNKNQNQNQNENENENQNQNENENENENENENEKREEPKKNHLSNLILENLTFSDLHNTNFHEPLSPRSLKKARKQEHYFEKKLTVLEKSRKKVFERWIAFHLSRFGINFTNISKDFTKGIKLIKLLEILSGKIVARFQKRPKNRVLRNENISIALNFAKYLGLNLRICPEDILDQNLILILSMAWEFILFFSVYRINTHQPIKPKPFFLFWASQKTSKFDIKIENYLSSWSNGIAFCAIIEAYKPGLIDLKALNPNESQKNLDIAFEIFELIGVPKFLESSDFISSTIDEKSIFAYLSEIFHKLATDQEVDEIINLYKKESIIIEKQNKTKEKSKISQFSKSKISPKAITPRKQMQGFQEFNTLTFKKIENNYQRELMILRKNNEERLIQLFTHLKTEQKNLEEAKKELEFFSINEINDNDNNNDNDNQIENEKEENQSKNENNFQLATQEDLQLLSKLEQQIKESQNEKNMLEENYREQISKLKEKQEHLQEILDKQQFSGKNMHSIKSNIFEEKQQIVEEMKIIKKEQEGLKTEIRDEKKKVQKLQELKKEHDKKVKDNKNGNKNNNGNNNNDDEESLKLKKTISEQKKQIEKLSQENEEFFWELKNQETEFTSKNEEADLQLKQNEENIVKNREIFENEKMALDKVAKEFGDNESSLNNAIQKIKTKNKQKKKRIEEIGEENEKMKLKIEEMKKITESKQNEVEEKRKELKKSEENIEEFHRKKEEEKNKKIQEMYESLTQDIKQNKEIHEALTRQYEQLMVSLREEAQQNKKMKNIIDYNQKIDSQKILELQKEMDELKKQKREQQEEQNAKIDERLSEIKKLNRILGEKNEKIQLLEDEISELNLNLQEEQKKHNKIITQLREEIEKEKSESQKLLNENASLSREFEESMSKFGVRISQLEEKLAQEKESQDLNYDQQEVQLRQTHTDYDKLSRMLNSKIQEIGELSKRAQEKVDHVKTVAQELENQQTQTKQMKERIQQLQALFNERNARLLDDQEERQIRFKLEQNERQTQEILLEIERLNLRKKLKAQYFNQQNQPQNDLIIPQNDLIIPQNETENQKFRRFINELNRLLADSQERVKKLEKEKKKLLEHGILSSTEKNKIHQIESHLKTLESHQVFILSSFEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDZ5</accession>
    <name>A0A9Q0RDZ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDZ5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="394"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="605" mass="70725" checksum="CB003A79B535970E" modified="2023-09-13" version="1">MNDCLFFGRNQKPILFKDEPYKITKPIQFKFENENENEKQIKQISTSFFGTIFLFKNGKSIEYLNENNSNQNPSKIQIEENIQKVTVGNENEAILTKEGNVFAKGNNINPKNPNEFINISSLIEDKNDRIIQNIVCGRESIYLLTSNQNSYGIGSNELSQLGFGTKTIYKTEKPILMMKNVSKIFSGKCSSYVFLLNSNQELFGCGNNANGQLGLGESRKKEEEIQKLTKIQNIPKGKIIDIQCGYYHSIMLIEDEDQNENQNPKRKLYSCGYYKFNGLGKNKDTYEFTEIKSPLFENYNIIDFSVGYSHTLILTSEPKLIGFGGNFSGELGTINTNSQLIPIQIELPKLRFNENIYNYHISCGYHNSFLYYSPLSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLKDYENEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPILYSEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTDDTSNKVTDYSELSNKSFEIFEYWIYSNQIKDKIEITQEIINEIKTGIDYFQLNQTYPNLFDLLINKFNNQNPNQIQKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE30</accession>
    <name>A0A9Q0RE30_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE30"/>
    <dbReference type="OrthoDB" id="61560at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="411"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="888" mass="104604" checksum="A95147BD17722234" modified="2023-09-13" version="1">MHLRSHKIVYRSKKRQKDIEQYNSETIQETFNESLKKIHLDSPKKKRKTKRKKNKQQKRKQKQKRKTNKTTRNTRKFISQNDLQIQNLQIIFQNIDQHFQPLLEEIVELSLAQLIEVASNYKISWIDKNSINIEDSNQNINENLNENSNQNINQNIIQNLNQNSNQNINQNLNQNINQNINQNIIQNINQNINQNINQNLNQNINQNLNQNINQNLNQNLNQNINQNLNQNTIQNTIQNIFENENQIKNDFIVVLQQSSYQTQNESNNMDIENSQKFITSTNKQNDTNQNLIQKIKIIVELVNFFQTSNRGYEEYEKSMKKTFSFQIGINCTKQKIEQINKLSIIELRKICQFYQIPVSKMKKIEISEILSLHTLPLSSLRRKCLRMNESLIGTKRELVERVIANKFHDEQPFIATVFNDILAEIFSYLDINHLVNCSNVCQSWRKVLMKKPQRKILKNTNHGETISIQKMESCCFFCREPDSTHSHFGVVFCTECYNRITDPSSLIQKFFCIKHYSLFDEDLEDIQEIRPYFNQDIVYYRALEIFKKIEAIYGSIDFPRKYKKAKLLHQHLLDRHCRFLPFSKEIKTSLQIKNQTLSWLRRENKMTGATIADLIVEDILQTLTKEFEDLLQNYQDENKNQLSEYLSNYIQEHPLTLETNTKVVFDQAVKQFHEHQRQELLDFFVSKCMISAQNPSVITQSNIYNMCKNSGFDPLLLEENLYTQNNCKIDLNPLVFCDASCLLDSYPQLSAQKIELIRNLSRLSLIEVQDILLAKYRKKFLSQHIRKAAEEFKKKTIERMSKEIIKTENENENENGNGNENTNENENENTNENENTQNLQVNYNSQQSIVLEDIQKDLHLDSIINEIAQDLISITKRTTRKSACGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REU8</accession>
    <name>A0A9Q0REU8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tenascin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REU8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040426358" evidence="4">
        <location>
            <begin position="19"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="443"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120372" checksum="A68BA4493C405D24" modified="2023-09-13" version="1">MKLFCFLLIFLIISSIKTKQFSQFSSTNNYSEWYLLQTLNGPSGSTISFGSATSISGDVLVVGDDDGNHAYIYRNNGSFFNLEATFSSPQSDFGLAVSASGDFVAVGAYTKDEAYVYAYNGSDWNLNLTLTGETSSFFGMNVLLSEDLLFVAATDLSQLYIYRFSSGSWTHQQTLSQPTVGYFCDAMSYSNDVLICGLVLSSNISYIYRYDGSTWNLEQELISNVSQQFALGVSISGDVFVVSAQDLNEVYTYAYNGSYWNLQQTFTGDSGYGYSVEISNDTLFVGNANNREVLVYDFNGTYWNLVQNISQPDSANFAQWISSSGNFTVIGTYNPKQVFVYEYVVLTEVNVINCSSLFSSFECFWERIVYPVEYQINYGFGWKDIQSPILEEDDVYYQEFNYSLYPNITGNFLYSIQLRACNATSSICSSSSSSINLTTRIDSVKNFELSSSSSQSIDATWDFPDVLIEEGVPELDHYIISYQNSSETTSTMISLANSSTSYLMTNLYCGSEYDISIWACRDSLCQGFDQGEIIQSSISTIFSQVSNFQCLISNVLLVSCSWDPPLDCVTPSYYYLTYQAISKNDTGNYQIISPTQITFFVQIPNQEYQINLSACHSDGNCGDISTLSLITNNLSAPIIIDSISEIEAIQLTFTQVSQAQAYLVSIDNGTNWINFTSIYENDNDDEVIGIISPLEGNVEYLISVRGCSDLNCNPEYLGLISSISAKAQLGNITSLNCTSVVCGFNCTWDQLNLSEGLEAFSFTYNSTRICLSNSTTSYDVSGLLGEVDYEISVFASADEDCGENNYSGIPSTITVKTNQLYAPIIIDSISETEAIELILQKDSQAQAYLVSIDNGTNWINFTSIYENDNDDEVIGTISPLGNVEYLISVRGCSDPNCNPEYLGLISSISAKAQLGNITSLNCTSSSSELSCSWDQLNLSEGLEAFSFTYNSTRICLSNSTTSYDVSGLNPLSNYKISVFASADEDCECSDYSGITSRVFISTLSPQTELSNQSSTNSTPIILGVVIPVIVLGSFVFVFFIIKKNKKKNKNSKQKDSNEKDLKEKDSNEKEMKEKDSNENELQTDSDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFE8</accession>
    <name>A0A9Q0RFE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFE8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="351" mass="40146" checksum="91C4F15214330754" modified="2023-09-13" version="1">MGNSPNALQIPKSKANNYLKRITTNSDPICLLSPTKEMIRANKVFMDLFRGSKKQVRKMQIVNQLPRLQTHFNNQSSVSIIEREVSNAIADINGRCSFFIQMKRFTGEIFWAHVGLLMVNVNTKPMCQVLIKETEKPQTIQVENIEEVETKLVVDLTDDPSDAQTAEFRMTGGTDSETSGPNLHSVGFTKTQFSSPSNSRNFDDLPPIAQETSLHLEPSPIDTQISELIHSTKSQIRACENMDLEHLIVPKLNAIERIFSDVNQRLAIDILQLKSNIQHKRIASKKKYDSLESDIQRRLEGMKEEQIIKKKIESENHSLKKEFRLYLNSIHQLQEISDKTIQLISQEQKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG40</accession>
    <name>A0A9Q0RG40_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deneddylase 1 isoform c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG40"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="297" mass="36162" checksum="CA3EE2E3406445DB" modified="2023-09-13" version="1">MLESQDLSIGLVNFLYPQYQNDVEFTRLDFEPTIQKLHQEYKDFQAFKNRRNQIYEDFDKFLEASKKSYPKLIDHFNNFVENRPRMNKIDVFSNWLMSPELRNQIELFESLIEFEKGVDGWKQLRTILFNFEECERLMKWDEKEPLDIIPIIYLTNHHYVCFLIDKQFHKIYLYNTIPKYAKKEVEDMGNHIKQYIKWRINENYEIEELVKKKIQEDGAQCGNSVLLFLWLIFTIKIPIEKAVEIINHSLAVRFRFMILKCICKSTRIQLLFKSPEFIQDIIQNHPKKYRHNSFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGN9</accession>
    <name>A0A9Q0RGN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription initiation factor iib</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGN9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="410" mass="47703" checksum="D6071BEE74B70023" modified="2023-09-13" version="1">MNEDIIKSDFESEQEDPNDFDFSLTFQQDGQRSLLLGQNINPEDQPYLFLGGNERTKSEKNAKEFLHQIIERISNNFNLDDIDQASIKSLLDEVIIAKEMKITVRLEVLAGSCVLFYSRIYHRPISIYDISSEIGCQPSKLTSICQEIGQVLERDFPKIDETNFIERYCNQIPILSLSPNISDNDNLKEKIDPNVRNQIIQETKQLVSYLSKSTTFSGKNPLVTVIGAIYWVSQIHEVKILIDDLEKITGFSKMGIRKRYKEISFFVLEFCKLLPWFNKDIKMISNQNFKFIVNHLAFLDWHKNRVDLRKKSSQNKKKRKQNNIDSFKEKNEVRIPKISQMPLIDQNSPFGFLEPFFDNLIQENHEKVNDSVIIGSDDDDHETGCYILSRENGKNFKKTIVEKLQKKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGR7</accession>
    <name>A0A9Q0RGR7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000031">
        <property type="protein sequence ID" value="KAJ5079497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGR7"/>
    <dbReference type="OrthoDB" id="6482909at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="297"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="483" mass="57480" checksum="9A035246C4B5DCF4" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFQNQNQNENQNESYFDFEIICEQNQISFKTHKSILSSRSEYFKSLFNSKMKEYQENKLILQDVSSSILSPILNYLYSGKIEINLENAIEILIFSSKYLIDELIEICLNFIKNNLQFETIIDILKLSEPMNLNQLLDSSYQFISDNFEEFIKTSFFLELEENHLKSILSNDDIFMNEFKIFQSIIKWGKHKSNINQEKEQFEKEEKEKLQNQISNIIDKIRFIDFSKQELKDTLKEDLIPNQISEKLIQFQKLQNDTKELNQFIEKENSFIFKSRFRFKSKIIKEKKHFNKLKEWINDEEFCSKMKKGFSAKKDGFDCKKWHSICDNKGKTLIIIQTKDNFIFGGFTQIGFTTDKSKWSENWRDSGHIRDSNAFIFSLRNDKNDRNPENFQFKKKEEFAIFYVSNDGPRFGEFDDIWIDADLLTGGTFFGNSYKLPKGIHYETEKANSYLAGSYDDWEIEELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGY7</accession>
    <name>A0A9Q0RGY7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGY7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="288" mass="34182" checksum="289CCC42233CE159" modified="2023-09-13" version="1">MQSLENQTDVRNEFEFFVQEQFESEQEQFESEPEQFESEPEQFESEPEQFELKQFDLFDPQENENDLGFNYGIIETEKETETEKEKEKEKEKEKEAKTITKEEMFRIQKLINEIPIYTQKGNQIKTKLQVLTQPVNEKGGGGTNKGFSYQEFIKNSQKEQLFPNFVFQVNFFVLLTNLEKEKKMKIYLEEDYVHNQSDPNVLIIIYFDPLYEQPESSLTKDFLVSLDTFSSKQQVKTDSPPPLDPLSITKNKTNPKHSKHSKSKRTKRKKNDHSNSDNNDLKHHRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHA5</accession>
    <name>A0A9Q0RHA5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho gtpase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000019">
        <property type="protein sequence ID" value="KAJ5079959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHA5"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MyTH4" evidence="3">
        <location>
            <begin position="77"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="312"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="492" mass="57976" checksum="CE6FAC25B358FA6B" modified="2023-09-13" version="1">MDLLFNFDIDHHQIPIPNKIQIPFLKYMEENTTTRLPIEIRLLINKLKDLKSPKDRFKFSSKGIFRRKRILIENYIFSEIPLKKPLISTHQKLPKFNITALSINRKIMMYMNDYKSGSPKKDNSKLNLATQILQTAKTTPELRDEIFLQLIKQTTGHPIEENCIKGWELMALCCQTFPPTRDIEEILLEFLLSNQKNQNQKISNFSRLAFHKVCLISQSSSLPPIIRDEIIHISEAPYRFHLFGASIEELLLHENENSNQNSNQNSNQNSNQNLNQNSNQNSNQNSNQNLNQNSNQNLNQNLNQNSNQNSNQNLNQNSNQNLNQPKIPFVLKFLTEKIRNSNMETGIFRIPPENIIFGEAQFLIDSENYEKFEQKNYSVHIFASLLKKWIRDLDPFLTEQIEEELINSKNTFEDYFQIISNNLTKPIFDSFSFLMTFLKWFLSFQKETKMDKKALSLIFISSFFEQLNEHREDILERRTQIFSILLENWKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHM8</accession>
    <name>A0A9Q0RHM8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHM8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="482" mass="57921" checksum="00130CC3AAAB9EF5" modified="2023-09-13" version="1">MKIFFNQLIEKKQKEKEEILKKNQQMKKEIDKSKLKSTDIISFTFINDLKQFSLISIYEIIQEINTIIKSEIFEWILEIKELEKKRKLFKLFGKEGEIFIKQNIQDYWKQYSQQTEMEDSKEIIKKFIQLKKQQIENIFKQITKEISEFKSKGNQIKKRILDNLEKIEINFENSFQSLPEKFYSSQKDDNSNQETHLKLEMSIHEQEHELLMTGNRFPANKENKINISFIIQENINSKIKTNSYFKLIQKIPEMIYPKMNPQFQNENFLNNLYVTQNFINPINQKEILNFRLRFFTRILLIIEPKSKSKIWIFLTQQEIEDIMEFILDLEMRNIKKDNNNNNNSNNNNNEDYNDYKDNDKRNSFILMSLDGAILGKFGSVFQQITTNKIKNQKSLREDPDFPLINEIRKTLFVLGLLKFHWGIFEIGGDKNEKLSNHLRRELENFNQLQDNFHQSFSQNLSTFKKKIQFNLEQISKNNSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHN5</accession>
    <name>A0A9Q0RHN5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHN5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="431"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="537" mass="62476" checksum="3D48780280E220C2" modified="2023-09-13" version="1">MNEVFFFGRNEVPKFKNIPIMNLKPTEIDFENEIENNIKQISLSHFSTIFLFKNGKAIEYLNEKDSKQNPQEIQIEENIQKVLVSIQNEAILTIEGNVFAKGYEINPKNPNQFINISSLIEDTNDRIIQDISCGADSVYLLTSNQNAYGIGGNYDSQLGVDSVTLQKTEKPILMMKNVSKIFSGNTSSSVFLLDSNQELFGCGDNYYGQLGLSGKDQKFCYSHYNGLGKNENIYKFTEIKSSLFENDDIIDFSIGYDHTLILTSNSKLIGFGGNSYGQLGTGNTNHQLIPTQSEFPKLRFNENISNYHVSCGDFYKSMIYYSFSFSNLEEDLIKLFERKEFCDISFKTKNEEIIEAHKLILKYRLNQNQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFTIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITKEMIDEIERGIDYFQLNQTNPNLFDLLINKFNNQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5T0</accession>
    <name>A0A9Q0L5T0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000141">
        <property type="protein sequence ID" value="KAJ5066498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5T0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19743" checksum="4342770B9B4222D2" modified="2023-09-13" version="1">MLILIKSKQGFVFGGYSSVGWSSNRSDWDFIIADNWGCKEDPKSFLFLLEAPGITSPIKIAKNSENESFNILYDLNRGPVFGGFFSDLSLDPQLKKGWCNQKIPNQNLNQNLKENLNQNLNQNSNENSNQNSNQNSNQNLNENSNQNLNQSFSEIFLAGEDEFEVEEVEIYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L635</accession>
    <name>A0A9Q0L635_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L635"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="163"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="448"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="555" mass="64041" checksum="BC8A239E2B145307" modified="2023-09-13" version="1">MNDCLFFGYNENPKLFKNEPDEITKPIQFKFENENENENEKQIKQISTGVSVGSGNEAILTKEGNVFARGENINSENPKEFINISSLIEDTNDRIIKDVVCGVSSTYLLTSNQNAYGIGSNNNGELGRPLPKHSEKPILMMKNVSKIFSGIASNFVFLLNSNQELFGCGNNTFGQLGLGGSRKAAMIKKLTQIQNIPKGKIIDIQSGYFHSIMLIENENENPKRKLYSCGDYENNGLGKNQKTYEFTEIKSSLFENDDIREFSSESNHTLILTEKGNFIGFGSNETGELGTGDTKNQLIPIQIELPKLRFNEEISNYHISCGFANSFIYYSSSPSSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHRLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEETSNKVADYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIKKGIDYFQLNQTNPNLFDLLINKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L665</accession>
    <name>A0A9Q0L665_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L665"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="167" mass="20387" checksum="8132A26D3F3651EC" modified="2023-09-13" version="1">MWNENIKFGEVVPTLIKKFQFNSKKIKIKKYSKISQNFFQPIEKEIQSFILIQKEPHIEDLRNILVDFLFSEKKFEMKLFFLFDFFCQKSKQIEDFQVFSNIKPEEIYHEIQQFLFNHQNIGEFIETTTLLFQTNYYQNGDQLTHLFFNEFTGNEPSKFFIQLFQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7A5</accession>
    <name>A0A9Q0L7A5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7A5"/>
    <dbReference type="OrthoDB" id="19030at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="207" mass="24163" checksum="BDBFEB01945259C8" modified="2023-09-13" version="1">MQIYNIFNPKISISSDFRFLIVDRMIYKGKSSFVVWEIVAGAPLKLKPIFYDQSISILDACFSPDSLCLITLPTRFKGYVFLKNSFDQNQDSIFYIEKGEFAFKPRQIGPLSILGPARNKFGEFIKMTHVENNYGKYSHNLMIILLGLILISQILENSEKLSLCNLNDEEIADYCLWKLIPQEFYYRGTEFVPLDKNMIRIIYNHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L861</accession>
    <name>A0A9Q0L861_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adiponectin receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L861"/>
    <dbReference type="OMA" id="LTTWECI"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="407" mass="47600" checksum="84124A7BF1D41336" modified="2023-09-13" version="1">MEKEEKQNELINFETDQKNKEKLKSDTDQKIIKPDQNKNKNKNENKKIMKKTLSQIEEIGFDSQVLTQQETSPLIEKNVSTTQIELETIYDDNNESNDIENLKEEIQNENQIQNENIKNKSKTKTKTKTKTKTKTKYTLYHLEKVGYKNTGFKRFVKTGYRMDYPYSLCIKSIFKMHNQTISIWVHLLGAVSFIFFAIYAYSKDTIIHSTKESKLILGIYLIGGFLCLLSSALYHTFECHSIRVYNILLSVDMTGVIIMMETSFIPIIFFNFPNHKKARNGYLIGMAILGLIMIYMIWWQRRFLDRRPFTRTFAFSSLGFYSLIPLIHMVAILSSKSAIEVFWRVMLVLVLYFIGAILTVFQIPERFSSIGRFDVIGNSHQLWHMFVAAAAIVHFFNVLYWIEHPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8J3</accession>
    <name>A0A9Q0L8J3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Import receptor subunit tom40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8J3"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="131" mass="15530" checksum="E89C24939223B826" modified="2023-09-13" version="1">MKSFKNRIRNINRSRLFTADFIKRRNRRPCILLTNEEITSRFSSQQDTQLKISCINNFSTFPAKYFNASYVQKISNRIGLGTEIIYNLDNGESVMDFGFYYRLRQVKVNTEIDYPRDQYLFGYGLRIGPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8L2</accession>
    <name>A0A9Q0L8L2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thada/death receptor interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8L2"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="3">
        <location>
            <begin position="630"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1011" mass="118474" checksum="4C61EE5BDFFBCBFE" modified="2023-09-13" version="1">MSQKKILRTKTLTNLPRLNTNFIEEISKMNETKIPIIFEAFLQSKTLDEQLVNLNKIEVRILELLDDLKNRRKVEEKKKAKEKIEKIEKIYGNLAKTIMAYLLYPGLTGIFSPISRIIAKMNKQFPNVIKPIIEEQINRFLLQIPQVWPQEIQKQTELFQNLQILSHVFGNNLFRSQVKEIITNEHIFAIVHFSELILNKFINEIIQKEYQFSTKLKGFINVIYKVISTLFTKDFEKFIGPIIEENKINTDLFFNQNQENNENQKSNFLHKLIKSTFSLLSLNISDRETISRSSFILLLILDQMTKNQDAFIINSVFTFFNIQTISFIKSQNQIENENQNQNQNQNQIENQIENQNQNQNQNQNQNQNQNQNQNQNQNQIENQNQNENQTKFSKNNMIWNYFLPLDSKKTSLSDFFQNLPMRSQIELLNGLTCSSKIKRLIKPFYIDSSESPNTILYDLLIDKFCTLSTTLKKEYEKFPSLVGLKNVLQQITKNYRLLEKSGFRKSNFVEKNNTRILNIIWDNIGNSESMISLDAKEVFEIWMKFCTNDIRIENLEKCLKISWNNNIKPLLITAVVKFIDAQEVFKINPNFFPEFFKILRDQLRNQRNTKLFTQMLQSLSSKMSLEEHSKYWLSPVIESLSSFDNKIRQPITEYVLPALLKFDTNIFQLILDKIIGNENENQKNFALLFLLRTARNLSIVDSSSLEYFFHGKKLNPQDSDDIIENLNGDSIIEKALLNADESIRLNAIELLTFHSKIGEPISLLEILLLRKYLIYSLKVVLPDHKKRISNCMLRLFPRIISTFTKQQNIESESKKLEIIKEFLVWFFSFIVYSLHPGSSFNRKTLFIPFLETITNFFPMIQFENENENENDNDSNLNVIQETISKVLFSTHSVMNFVNNLIEGWDQTRIISFEILKKIPSKIIGFSNLQFVSNMLAWTIGKLLKAKKLREADTGSKVIQLIFKKSVIEFGWNFKNWDHKQRKTIQIKTHNNQVGYLHKGGSFCGKARSGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8M2</accession>
    <name>A0A9Q0L8M2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urocanate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_03099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8M2"/>
    <dbReference type="OMA" id="VHFQGLP"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006548">
        <property type="term" value="P:L-histidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1770.10:FF:000002">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="entry name" value="Urocanase like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1770.10">
        <property type="entry name" value="Urocanase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216:SF3">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase Rossmann-like" evidence="4">
        <location>
            <begin position="139"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase C-terminal" evidence="6">
        <location>
            <begin position="321"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase C-terminal" evidence="6">
        <location>
            <begin position="466"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="537" mass="60076" checksum="6FA773952F82EF37" modified="2023-09-13" version="1">MYRFRPSYPMYARPFKEYKTKCKQAAAMMVMIQNNLDPKVAQFPHELITYGGNGTVFSNWAQYQLTMKYLSELTEEQTLMMYSGNPMGLFPSNKENPRVVISNGMVIPNYSSKQDYEKMNAMGVTIYGQMTAGSWAYIGPQGIVHGTTLTLMNAGRKYLNTDDLTGKVFVSSGLGAQGKAVVIAGAIGVIAEVDEKALNKRFQQGWIMEVAKTVDEVWEKVKKAKEEKRSTSIAFLGNVVTLWEELAKNPEVEIDLGSDQTSLHNPYNGGRFLLYFQIINDKIDLKIKKKLKAKADILTDPNDFTSFKYPSYVQDIMGPMIFDYGFGPFRWVCTSGLPEDLQKTDDIAAEVCSQLSKEAPKEIAQQYNDNYKWIKQAKENKLVVGSQARILYSDEIGRIKIALAFNQAIKEGKVTAPVVISRDHHDVSGTDSPFRETSNIEDGSKFTADMAIHNVIGDSFRGATWGGFGIVIDGTEECAKRIQSMLMFDVNNGIARRAWAGNQGAIFAIKRAMNNHSKLQVTLPNEVDSKILDDLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Y1</accession>
    <name>A0A9Q0L8Y1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8Y1"/>
    <dbReference type="OMA" id="HIRREMV"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="GCR1-cAMP_receptor"/>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="6"/>
            <end position="28"/>
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            <begin position="40"/>
            <end position="61"/>
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            <begin position="5"/>
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        <source>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="314" mass="36676" checksum="C29C1E012E2AB70B" modified="2023-09-13" version="1">MAFYIFFPDLLGATLGSIGALVIIFVHFKFRDLRTFYRKLIFILSIYDLITALVYTLPGHYVHAICVFQPIVISFFIPTAAYWAAVISIITSLKITKNISEETLDKLQKIAHLILWLISGTIAIIFAVFSTPQPHARIYWCWVKEIYLTKLLYFVWWAYLLISLLFYIYTIIKIRKVFQEVAHLKNFLLKKQTRKNLRTQLRMSMIPLVYILIVIPTSVKRGKEMFEKDTKDIPFLDFLQALFLSTQGFFDCLIFVIGVRRVRQRLFSLCSSKPSKEDDESQPLVWVAEEDDENKNESLESEDDLGLQEVQTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L909</accession>
    <name>A0A9Q0L909_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleolar and coiled-body phosphoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
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            <begin position="363"/>
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        </location>
    </feature>
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        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
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            <end position="423"/>
        </location>
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            <begin position="425"/>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="732" mass="85636" checksum="38EAC4D32E795DC8" modified="2023-09-13" version="1">MISSKDLIAQHYNWFSEVVKAEITPNIDDLTFQKYLCQAIQLILPQFGSNLTPSNVIEQFKKISKKQGVPEKALEKLDKTQMILILKQVQTDFYENQILSKRNFFEVHFLDSNNEIKETGSITLVNKKITVYQKAQSFEQEINQNTKIKIHPQNSNVIKLIFDRKTFFILFSNHEERYLFVEEFTKIKHIILAQKNKGKKYKNVIQYLKSKEKNEKKDQQKNQKNKKKEKTKKKPKTQKKKQEKKPKKSKAKSKLDEMLELDQKICEVKFLVEILDELFQTKQEAYLVLKEKEFNVVTPENITRTRYNKQLKIYFEPQSLILARINFKTHSYFVKFPSQKQAEHFLMLYKFFKEHSIKLGYSDNTKKNSSENLNNQVVTTSTTSTTSDISLTKSSQTNSTRSYSSQSTADTTSLTSTSKSRQTFESEDESSDDQEDDPKNDEKKIPSIFSVVVSIPFKNYFGDGIIETENSTVKLIVDSLPFTTQAPKSEIKFFAHKTNPRLGKILFPGSEHLVISFHSSHKLLLFMEKLQEDPKQNTSQEKLNQNSIHLDILSKDLKILDTGEMVFSDLFIKIFTTEKEFLINAQTNAKIRKHTKRPCVYQITFESSEQPILIKFPSLQYVRQFSQKFHELKKQRKQQAQSKQFTLTIVNSKFEKISSIKVSFVDGFCYEDQRDHKQIIEKNPQKILLESHPKFHNILRLKFNSISVMIAFDDEEQRNSFVSSFQSFQNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9C5</accession>
    <name>A0A9Q0L9C5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rabconnectin-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="815"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2016"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1526"/>
            <end position="1538"/>
        </location>
    </feature>
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        <location>
            <begin position="1544"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2024"/>
            <end position="2035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2528" mass="294374" checksum="DD0AFD3D37C80F9C" modified="2023-09-13" version="1">MNNQNTQQSFILSPTQNITPIPTNRIEHTEISNKLIFSYFSNSTIYTVNHRLYPISQFNIKDSQPVCLAWSNLSNLLAVGTTSNIQFYQLFYENEDYQFSFLSSLDYIAKKMFWSQFDNYFIISSEKLLIFKMNSKKEFEKYYEIPVFSDILDCQFSPDERLFFTVCKDQSFAKVWFRQSKSSKDLNFIYLRHPSKVLSAQWRTGYHLTTNTPRKQVLLTLCQDGIVRIWSETNFCEPFCFYVCNVLVRSPNIQVCWLNAKPLPSQKPLELNISAIDKDTQDTNNDEKDENPKKSMKNINITNTNTNSNTNTNTNSHTNSFDEYNEDKMTRSTSNLSDSENSIVEYEAHENQDNLKISIIQNKAEGPHGHQYLLTSEINQAREFYIKSSSEKTRDLILGIDSQGTIIIWIIKGLSEQSRKTPTIQEFAKFTQAINMFTPSSNLTYLFVSQNSYKSWPFFWSGDRKTLLPSHLKFYTQITYYKKNENTPNHPFTEFSFWEIEYGKGISEYSQTKPLVSFDLPAKSPSLQKRQIKENLNTEKEKNNDNNNNNNNNNNNDKKNRNKNKKKKKIAQKSALKKKIPKKRTEKKDHHSLQTPTSWLTLRSNLIGHSSEIIKVISHSNLPLIGSLDIDGNCFLWTYSESKFQAKSKGLHSLGCLNLLLKNKQFPSNSAFKNIFFSPELPLLFAQDVNGLHCFDIHMQNYKSISSIFKFSQTVLKPEEYNIKNGILDIQIFVSNQPQFLVLCFSSFDKKHLILKMIPFSRQKNQISLSPSSEHKNINEIELDSHEEIAIIAKPLNTCISSDSTSLFNLLVADFFHFETSQKNISILKAINIDKFATFSENESFIYIWTLKSSFPTFGLEQKISITNNSQQNSNIQFDWFDIQNNTQILTVSDGRKIIIYGSKPVCDEYIYQSFIYQKPTERNNQESFETISYWQPLAEFANQTQEKNKFGAFQWSSNGFLLVSNLDTLHVLRSVHQDHKENNDSEFETSQELSIPNIIYKKTRPLPYYHSQNLFSDLKAGKFNRIEALFEHFFNFLKQKIENPQFMTPEIGLPLDIQEMLNLSQNEQEKTQNYDAIFETRDLSQEDDKPDKKEKLKKIKSWITQINIFPQDEYPKEETIKIISLIEVFCIKDEIKGALDDPSFNFFLQLKYNEILDQNRKQFEIKKDQDENQENAEETRNKSEKDQEKQPTLSIMNANKESACSYENYFFSSADVAWAFLSDSQEQLIQSCFPSPELFKWRNIRALGCGYWVKSQQTLQSLVEKIAISEFKARENPEDCALFYLAMKKVAVLSGIYKTTKDIKLSKFLQNNFQEQRWKTAALKNIYKLLGLRRFDLAASFFLLIDKIDDAIGVIIKNIQDIQLAVVVARLYLGDQNENFLNFILEKILPLATNQNDVFMQFIFYFWSKKYQESVNCLLGLSYQNKTILPQITNNEQQPTIILQNQDSRFIKKPFDYSLIQFIQQIKQNISIKNIKISQESFVNCWKNSFHLHSIQGSSFLAFENLQILEDLLLKKEDVDLDQNSQKKEQNEKEKSDVFGFDENNESDKNDENDENNDNNENDENNFDDMDNDNDGDGDGFGFGFGFGGGTTTSTFSYGIDLDNFDESQFDDDNDTQEEKQNENSIEKEIEIEIEKEKEKEKENIEFEEKEKNQLQDNLSKDIIKHFQFEYSLELLSQFLPQTSLEFTIEYPGYLFAKKKEREIEFISKICNQIASIIEQNDINLIRSFSQRKAFEFAQSLLILYRAQKSLQKKEDPNSVKIISRAIFTLYFGIFVFGFSQKRYDIILHFFKRELQEEDFFTDLITKLQNFVQEYIENYSEAVKSIDIQKAKTEEDIYDFELKKRLGLIENEDEKEKEKDQKKPSFEQKAKQRAQKNMQNINQVDLFFENIKRIAFYLSDLAVLHFFKTYLKIQFVKWFGSGMTENSQMTTPLKIEQQILVSMEHLKSETRDNLFKFCSHHIDLIPNFTLFLEEVLGFNFEDEKCNDLWKLIKQKYQMFLVDTIKDIMRKNTYYNSEPGMESQQREGENKESTTKGVLTEKKIKELRAAKTHVLHTSSGLIRSFCLNSLNHNQITIASTKGLRTFDTVPEIVSDNKVKLLSRNLTTADTYDLENLKNQPKDKSQKSYEDITTTKMDFTQKVKSSEVQFDSLSRLKKKNTIANLSVQNLSKQPKSHVPIFEKNKSTNPMHSYATPDIISKNVDKFKVEKILTGPIYQSRTPVLQFDDYYSYLRKKRQRIASLIQENNFIERKKNLRESYESTWVESHPKSPFYVSSGLDGELLLLEFDSDSYIHQIQKPNNKRITKLYFNQEGSRFGICDSTGQITLWDFDSQNSGFAPFYTLDSFLHRVNDFLFVNSGSVIATLGKTDAKTECVSLWDILLPSDNNRVTSFPIKKDGGASSLAFSKRYNLLVTGGKKGKLHIFDIRKSETLLTIKQKSTSTIKTISLDPNDHLISVGSMDGSISLYEFPTFKLVKKWKAVHEKKHLFRDKGSTHRMTTYGVTRVLLTEHGVYSSGGDGKMIVRYFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9E4</accession>
    <name>A0A9Q0L9E4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Retinoblastoma-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the retinoblastoma protein (RB) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9E4"/>
    <dbReference type="OrthoDB" id="844594at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002720">
        <property type="entry name" value="RB_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002719">
        <property type="entry name" value="RB_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024599">
        <property type="entry name" value="RB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF17">
        <property type="entry name" value="RE32990P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11934">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01858">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01857">
        <property type="entry name" value="RB_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01368">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein A-box" evidence="10">
        <location>
            <begin position="426"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="880"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="956"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="512"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="880"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="976" mass="115680" checksum="7C58CB91F34D755D" modified="2023-09-13" version="1">MDDVLNHLCKKLKISKKKFIEKISLELNQFEKKYFKSKKKRKTKTKIKPNKHELEYWVMCSIFNNCENPIQIEKLKRFEWTTFFHYYKQFCSVIKPTKEKQTLLTSLQKELVHLTILFEKYKHFFNDFVRIHSSFNSQTFPFQSMEENSLRNQSNVHQYPANAFEKNTGMNSLLFSFGWLIFVIVKKLLLVDQFNLFLSYCLLGCIIKMMNLSVKDFVSSQFDFSQMKSESTKIQEIYDNFFVPCVRKLENQSILHITNKEKQNEDEFFSTLLSHIEYNYENLKKKYQSIIEEEKRLNIIILDGRVFLDIDRKKEAEKEEEQEAMEIDLLSENYLNSRSQSNLFTKKENGNENENENENENNENKAEKTDQNSQTKDLEKSKNERKKMNEKIQKDFENSLEEMKKKQNEIQTPVKQPKQVNFSPATPFSQAINKTPMMRRGTPGTLIYNWFSQTISEIPLPPILFFHQFSSRFSENFLLNFLENSVEIIKSIPFNQVKTYKINDLIPKKENTNLNQNENTNENQNLNELKNENQNQNEIQNKKIMIEKEILKLSKRQKLAVQFSLFILAQMIEDKTNLNSNNESYILPNTEFKKALIGFSCQVLINIYKIVRLPFPFILKHLKISPFVFFKIHTLIIMKAQEILPKTLKEYLQKNEEAIIESLAWESEDSEVVVILDKFDQSQREEIIESTGIMKKSNLEVKKNKPQKENNEKIEISAPFRIFIMKLLMLVYQRIALLVSSFPQFNELTFQEIWKTFKHVLVAHHHMLIHRHIDQVMVCCVYSVCSIFKIQVKFNDIISEYLKQPQSNKSVFLNVFQSSSKNFDVINFYYSLFQIEMKDWFCKMEYSAENLLDQFQNTSFTKIPFGTPIRRDILQNQNMNESSNKQNISPRTPKTLNQENQENQENQENQKFPKIKPNYLKTSQFYSNGENLYQFTKSPTSKKRKQQPTIAAEFFNLPQDSACDLTEPSPKSSQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9F4</accession>
    <name>A0A9Q0L9F4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dymeclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dymeclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9F4"/>
    <dbReference type="OMA" id="QINDFTE"/>
    <dbReference type="OrthoDB" id="10253409at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895:SF9">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="686"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5068553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="931" mass="109737" checksum="270A3670916E065C" modified="2023-09-13" version="1">MSVDFSKSNFIISITGKKPIEKTDQKLWNTFSTEFNTPLTRLNIEEAYIAINEQFPDFCSNNLKTNNFMTIISKFINFLKESSGEKFDKKINSKNSLLITNILFIARVLLHIIIQDCFPSAKISCFKQEKFEKKNKKKKNLFRKERKSLDKNVQKNKKKDQVEQQLTDTDDSSEKSKTQDQDVNDLSNSIDKIKKHLQIETEQKNLKNLFNSIFDFIIMNPQTLDHPTYVVINEMISFLLVLFSITFFDTKKLLLKDQNKKKDILADSDTLPDDWVEDSKSDFGKNSLTESISLDTQNPFLNISNEKAKKLVKILLNHIILQMPTPKSVDPVWGTQLRKGSFFSRSLSKKTAQKLVVDPSPLATQSILLLIALFQINDFTESDQILNSGNQMIKETKEQEIQLNSKITFQNQIQIQYGFDEYDNEKEKEDDNMEQNSETELLERNYFTPSNIYLKTITQLTAKKFQSENENEKEKENENSTEKENQNKENEKENEKQKENENTIGINFSELLFCLASSERVNEHYLVLFYYMIYNNWDFITFVSKNANLTSYLTNLLEELYQYRLSEEELQKEKVPFIYLILIVLLVLSGRRRFRKFIFSSNLQSVNWYKDKQLSNISLGHLTVIILMETLHYHLLKFPKKEIFLLSLSILNNLSSLFTNLFANETKKLLEIVSFVSQKVKDFSNFDDPTSKEETISNEMKKKKTRNKKDKKKKKTDKKSKIRKSESICEVENQVIEEMIEKIGMEFSYTNDYIDIESLKPSPSLLTRPDRLVRKDNRNAFVKFQNEKTAELHLYSDYLLILFSLINTTLTNQFNNNTQLIYTLLKHRRLFSPFSAHPVLWKYVSNFHKLDKFFDIDFLERKNTPYEEILQNIQNSVPNFVFQEKGFFIIENKLFKFQEFKPKNNIFSTFSWLIINKNLTLRWDLDFIHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB17</accession>
    <name>A0A9Q0LB17_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB17"/>
    <dbReference type="OMA" id="GCVIIEV"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF7">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="386" mass="45774" checksum="E7934E21E5B6DDDE" modified="2023-09-13" version="1">MGKRKQPCCVCGYWFENYWNRPDTIIISLDFEKFESPFICQGCYRTNYRMNGKTNVTPQQVVVASLMSEIVSETQFNRICRDYGNDIQYLLDQALDFNRQCAKKSFNPKGWKARESSTIFFDVDQNSIFDVIHVTRRQGYKGFSNQMEKEAVNRFGQKWKDKITLHTLIHDNCKNIKSVVQGYWPKVQEQLDVSHYGKNIRKKIEKSGKKFHSLEGKGQSVKNWFRSSIESSNGDVKRFNELMQLGVNHYENKNHDHCSQCKQKKQNPNYWISDPNEQKEFERHIENIIKDSDKIIGGYNTNSCESFFSSKTKYIPKRINAPSQYEFRVNMAVLDRECPAWRELLSEQWGWKIPEVFYNIQKRKDQKKQHKQNSQKLQKNKKNNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBE7</accession>
    <name>A0A9Q0LBE7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_11774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBE7"/>
    <dbReference type="OMA" id="YEMHLGS"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="202"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5069289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="686" mass="79919" checksum="B8E3DFA226CBF44F" modified="2023-09-13" version="1">MQKKAEETIKKLIEKDPLLKPYEEHLIQRNLKYEETKQKIISQEISLIKFASAYRYFGFQRITNGIIFREWAPNATEMSLVGEFNGWDPTKHICIKDEYGVFSVIVEDQGEPKQPQIRDDSKIKIRMKTKSGEELYRIPVWSRRTTQDLGNPLFEGKFVNENKYKFVSRSPRKAVLEGGLRIYEAHVGMSSKEPKVSSYNEFRKDILPYIAQLGYNCVQLMAIMEHPYYASFGYQITHPFAPSSRFGSIEDLKLLIDEAHARKLLVILDIVHSHVSMNVEDGINKFDGTDYQYFHSGKKGIHPIWDSRLFNYAKYEVLRLLLSNARYWVEEFNFDGLRFDGVTSMMYSHHGINHEFNSYDDYFDTKFQSNADLDGIVYLMLVNDLVHSLDPSLITIAEDVSGYPGLCLKLDQGGIGFDYRFAMNIPDLWKNLLKSKKDENWNIGDIVGSLLNRRTGEKVIAYAECHDQALVGDKTISFWLMDKYMYKGMSILDPISPQVSRGISLHKIIRLITFSLGGDAYLNFMGNEFGHPEWIDFPREQNSNSFHFCRRRWDLAQDPLLRYHHLLNFDTAMLRLDAEYHLFSNPFVKIISVHEDKKLLFFERSDSFIFLFNFHPSESYTDYRLGSSWQGKFVDILNTDLISFGGFDRLKNGSEYFTENKSWNERPYSLKVYLPSRVAIVLKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBQ0</accession>
    <name>A0A9Q0LBQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A1 cistron splicing factor aar2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBQ0"/>
    <dbReference type="OMA" id="VWQSGGL"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="200"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="388" mass="46459" checksum="2DCAD96F52837F2A" modified="2023-09-13" version="1">MQKLDQQKAFQINQNGISLLILNSPSNLQFGVDYKSFQTGPNFKGMKMIPPGLHFVFYRVHPFIVHSFFFNGKPGDVFVYQWDNQKELFFEFQDLEQKNRFINGVKNFDFDSNLAPYPLEFYSKWKKLSQFISLKSLKPFLDYENENQLENENENTNQNQNQNQNQNQNQNKNQNENQNQNENQNQNQIENQNKNEKLPFIKIPKIILPQNITQKEITHFGMDKSYTLEQFIKKNFSSNENEFLAHFQISFIYFLLGEKFQALEQWKSCIELICSCEEIVTKKWKFFSNFLSILKFQLKHYPEDSLFQEGNDPNNFIWFHLNQFFEMNSDCLEISPKIKSLKKFLNQKYHWNFNISEFSIETSEFAPVLVYLTKEQRKELNIDSDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBW2</accession>
    <name>A0A9Q0LBW2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_11392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBW2"/>
    <dbReference type="OMA" id="RYSWQTA"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5070027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="288" mass="33015" checksum="EAFABABFF93D29A5" modified="2023-09-13" version="1">MEKKFCIGIDEAGRGCVLGSMIYSSCVCPKNKKKSLKKYGVDDSKKLTRKKRNEIFNTLKTKKYVEFGIKVISSEEISMKMLRNEPENLNLISHKAAINLIKFATKKFNIAEVYVDTVGPAKKYKQLLKKNFPKIPKIVVEEKADSKYPLVSAASICAKVHRDDMLENWIFKEININIDRAFGLGYTSESAVTNWMKKNSDFVFGFPTIIRFSWKTTILFMQKNCAKINLKKKQEKIKIKKTNKKSIRGKRKRSPNSSQLSQNSIEKGNLNTTFFIKRGISSTKINDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC29</accession>
    <name>A0A9Q0LC29_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-10-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC29"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="403" mass="47109" checksum="E680F52234385A6F" modified="2023-09-13" version="1">MKFHRLKKIGFRFRRYVRRLQMQKSTPFRPIVFDNGTGFSKIGFAEDMSPQFIIRSIVGNEDYLDRLNQLTSKELSFKQYYIQEESIIKRKILILKYPIEQGVITNWDDMETLWKYSFENKLKISPEEHSVVLTDSIKNPKKNREKAIEIMFEKFGIQNFYIEKQPVLPMIQMKKKTGIVVDIGDSIIQIVPFFQGKIILNGVKTINLGGRDLTNYMAKILTEKGFSFITAFEREFVRDIKETLCFSSSDFDLDLKIAEEEPHQFNKEYVLPDDTSITIGNERFRCPEVLFQPYLLRIEDPGIHEQIFESIMKCDQKIRKNLFQNIILSGSSSMFPGFSDRLQKEIYQLCPENTEVKVIADSIRDISVWVGGACFALDKNNQKWISKKNYQDSGVSIVHQKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDF8</accession>
    <name>A0A9Q0LDF8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDF8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="39696" checksum="2077DFE848EF11CD" modified="2023-09-13" version="1">MGNSKSAKIIKRKETETYLKSIREAKEAMILISLEDHFCIEVNDSCAKLLGLTCREELVNKIVDPNFSAPFQPQLNKPLKEAIEEQTQRILKNTTANIDFYWLHKNTQNQDVWVHLYVTIIQLKGKICFQCVSIPILNPLENEIIETPLDQSLYLVNPQFIGKSESDSSPKEKDSLEEDESKSTTEFSDLESQAEQIISSPKKYQSAYNIFLILNDEFEMKLDYIINKIKFHIRIHQNPKLEKEIIDELNKIKLIFEKCDEINQNHISKLVDKLGIEREKHKARYNELECHFQKNIEKSKKRELEFNLVNSKLEKIQEIVTDPKIIEFLAQDLQEEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDP7</accession>
    <name>A0A9Q0LDP7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDP7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="301" mass="36931" checksum="F565FD67C1A6AB31" modified="2023-09-13" version="1">MFIVHISSNQEETNTFHFSFEKNFEYYYIDDIFQYDFEMNIDLKTTFPGNYLEKVIEENWEKIFELIIPISILKFLNSKKKIEKTKKFFEEMKLSKNKEILMKKIREMIQKGKNGNIKLYEWNINELINEKFEKKRRNESLTSFIQFKFKEKLETIFAILFSNIMINDNFKLFPINQKDTNEIQKLWEKIFKNLKIPHFQNILTYQFNNSNFPFFQYFYSKLFEETKQQEENKIIQEIIEKPIIKWSNQYSKNPKTTAQIFLKAFMSDFTKISFTKEEQKFLEEYIGNISDFIYQFEKMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEB2</accession>
    <name>A0A9Q0LEB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEB2"/>
    <dbReference type="OrthoDB" id="10649809at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="334" mass="38358" checksum="624368E18B582E2E" modified="2023-09-13" version="1">MGNSKSAKIIKKSKVKSYLKTVREAKEPIVVVDASDFCIETNDLYAKLLGLRSRNDLLNKQMDPNFSPSFQPQFNKNSREAAEQEIGKVLKSSTGTHDLYWLHKDTQNRDVWVHSYLTLIILKGKSCVQCISRPIPNPLENKVQEAPLDQTLYLVNPQFVGKNESESSQKDKSSQKDKDSVIDESKSTTEFSDLDSKQETKTTTTTTKSQSIPNVFFLSNDEFELELDDQIDTIKSIIRANENPKLEKKVIDKLNRIKSIFEECNKSNHTQIAKLVERLEKEKQQNKEKYNQLESHLQKNLEKSEKTKLGFDLAISKLQKIHELTTDPNITQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEQ7</accession>
    <name>A0A9Q0LEQ7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02011</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEQ7"/>
    <dbReference type="OMA" id="RISHNAF"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="9">
        <location>
            <begin position="550"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="10">
        <location>
            <begin position="680"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1023"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1139"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5071029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1243" mass="144574" checksum="587982CF8207A147" modified="2023-09-13" version="1">MTSSDIYFEQELYHQKLFFSIDFIEHSLDCVSKLFFNSHSNIENITNITLHLNQCLVSEVQFNSQSVPFKYSMGQNDYILSPDSESDLKQFTSTFNQKMKKTGILEIPIENLDQKDFENPFDLTVFYKLKDPQIGIHFCKDKSNNTEYIFTENRSYDSRSWFPSIHLLTVHCTFEIEIEVPANYTAISNGVLEKKIYSPNKKTTIFYYNHSFDSTPSSIGFVAGLFDEITVFKRKPVIPTTNQQEIMVESPKKDWIENDENNENTNEIQIENENNENTNEIQIENENNENSNEIQIENENENGNGNQNGNSLVCFSYCLTGKDSKNLHKMKTSTQTIPKIVVYLESLLDFSFPFSTFKVIFLPIPYKNELSFSGFTILSMNYLYDENIVNSVINSQRMIAYSFSYQFFGRFLHFQNAKDHWIYTGIAGYLENLSIRTLFGRSEFLYNKIKQIEFVCDEDIFGGILRDRRDPLSFIPRNDDLYIKKSILVIEMLEVRISHNAFRRVLKQLLENGSKSAQKTMITTKIFFTLCKKMTGVNLKSFAEQWVYGSGFPIFKCSYVFNKRKQEVDLTIEQDFGGKNSQIFTGKLKYKIKIKRTISIQISEFEGVYDHILNIDQKSSIFHIPVTSRLHKHRKKKISYENGDEIEFQLSRTSSPLLYIRVDPNREWVSKIEFQQFPEMWFRQLLLDRNVLAQYDAIHSLSKNKEGNEGDITNFLIDQLHQNRIYCKIRSECAYGIVFLVTGTQSWNLANKLIEYYRLNFFDQETVAQNGGCVKPNSFNNLEEYIIQKEIPVALSHLKDENNQTPKIIIEFILDLLKLNDNSINDFSDDLYISNIISSLTNISSFSSEAYSKIFKQIERFLEHDRIFPSQNNILSITCLETLASLGNRIIISEDFLRNFCSIDFPENVRIAAYIASLQTAAEEQVAEILATIIKEVILTKSNAETSPFFMETLFTKIIVSFKKNLVVLNTSLDEILFGLWNLLNDKIASDLCLRPLLFQLYALLAYSQSPEVLHQYYLNSENHQKSGKKDRRSRSSDSQNKSHHRSAKDRDSHKTDSSLNAEPEKTKALPSLLFATFVPLDQQNEPQEIMKVSVWQQQFATVQIEEETSEEAETQNVHEIKEKKEKGDEVNKPQKIPSQKKKQKTKTKTKTKTKTTSSRSHKKYRKKSKRKVLPKIHLLSPLDPIKIPRCFIKKKSDVIVNKVEKPKMIEFKFKDGRIWRLKLEIGKYVSKSDNKRIVLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFC6</accession>
    <name>A0A9Q0LFC6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFC6"/>
    <dbReference type="OrthoDB" id="298084at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="305"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="475" mass="55286" checksum="2D62B6A61E305BFF" modified="2023-09-13" version="1">METYSNLEKLSNDLQNLFQNQKEEDYFDFEVVCQQNEETQPISFKTHKSILSSRSEYFKNFFNSKIKDLEENKMILLGVSSGSVYSILNYLYSGKIEMSLQNAVEILHFSTRFSINEVIEIASNYIQKNLQIANVVDVLNLSESMNFNQLIELCYQFISTHFDEFIQTPFFLQLEERHLVFILSQDDIKTNEFTIFNSLISWGKHKLNINKTNLRLDNKEKEALQNQISNAIHKIRFIDISSDNLDTALKQGLIPRDVSQKIIEFQNINSLKSGNKLNEFLRNHQEETKSINSLIFQSRIQFNSQIIKEREHFNKLKEWIKDDDFFSRMRLGFSAKRDGFTGTKWHDICDDKGKTLVVIKTTDNYIFGGFTQVGWSKGPNRWIQDSDSFLFSLKNPKLDPPQKLPISNPRESKFALHYHALYGPIFGYGHDLILHSDLQPGFSNIGHSYDPPKGIKSETTEAENYLAGSYSNWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGD5</accession>
    <name>A0A9Q0LGD5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGD5"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="171" mass="20092" checksum="DEB8E985A0CFB531" modified="2023-09-13" version="1">MLLYIRTLSGQTIKVDIYPSETIKYLKEKIGEEKKEWDPDCLLLIFAGKLLENDKIISDYNISKNSSIHVIQSFDKIVYINIFHPIKRVLPLFRGSFSPNLQILVFENTLQDILAKISLKKYEIEGTSLIYEGKRLEYNKKLSYYQKSNENPSLDIFSLIKINIKKIKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGJ7</accession>
    <name>A0A9Q0LGJ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGJ7"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="197" mass="23668" checksum="4EAAE41ADD1ADEE3" modified="2023-09-13" version="1">MRLHDKFPENCDEKLISEKLSHLFYPLRSKKSREIQLILKFLYTGIFDVEEETKQSLVGYMHEMGLDDSWIESKQGRKSILQDLQFLYSNYKPDFYIKKEDKKYGVHKLILIARSDLFRGMFLSVQDSSNEVNDYSGKSNTSFQQFIHFLYFDEIQPDLPQEIVEEMFDIPEYFQLNENSLLIFLLDNYHQYRIQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGL5</accession>
    <name>A0A9Q0LGL5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stromal cell-derived factor 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGL5"/>
    <dbReference type="OMA" id="KPQHGTR"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040404405" evidence="3">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="22932" checksum="061434797FAEDFBD" modified="2023-09-13" version="1">MTKKIIRIINIIIIITLVASEETKEEKVAITCGSIIKLSNEKTGHRLHSHSVTYGTGSRQQSVTGFPEGNDVNSFWIVRGATGTECKQGEAINDGDIITLEHLVTRKRLHSHPHKSPLSNQQEVSAYDGKDVRDNWIVITQGQWIRDNVVVLKHLDSNQFLHNHLKEYGRPIPHQTEISCVSSSKGKEVKWRVVEGIFFPQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGV8</accession>
    <name>A0A9Q0LGV8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGV8"/>
    <dbReference type="OMA" id="ETCANEK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1107" mass="130587" checksum="883CCE5E4A38C0A4" modified="2023-09-13" version="1">MELISLNNSNEEFSFIDFIGNLNDQFQKNKFNINLIAKNLQNFINNLNNEKIQNLPATLKILDIYEFLIAGTINTNSEKISNSLFIINLLFDDSSYSFISTNLDHFKLLNQAYIVNNLKNYLDLYKKAFIKMKESNSEIETDLELIFCSFPEKQNEFAFSQKYPKISSDSNIQSILKAEIIQRFGFYSGFQFLNNHLDNLITKNDLFPIIQILKIFQKISPFLSSKSYQKFIEPKFNLLIKMLNPDPIYLYTSQYIINLIFKLLTYSSNKEKFIPQLFQIQLQFAQKMDHFEDIISWKTILSIAGNFFKYQNQNSIKKFIFQKFPFISSTLLPKILDKIQQFFQAPNLDQLEEHAKLLKKSNILAFCASSDQIPFTFINSFWDIITQNNFEISQTWIACFHQISSQVPDQIITKIESLIDEYWRKKQSKNSLITENELDFYKQNAIESLKNPNFQFQKMSNFSKKIQKNLLSILKLKERNKVGDDLSEQTQISSFNLDNFSPISLKIIWEIVSANNNNNIIIHQKALENIKSVLTQDPKIIFKNIFEVFCIDCIIKISNTNITILKILGSIISSYSHYKESISFKIHKLVDIISLFIEYINIVITIEEQKETLKTLKKILFKIKDMKLSYYQMIQLTDTFLQKSDHEKDMFWEWMNKLIKFHINNSKYGKNLCFKKESLDNFCNYFVSQVKPSLISETGFSIFESIFIYINREKKNILIEENNLQKLQVIANSIDLDYLYDVAIFCENPNVSKEASQFLANIFNSLNFPKMEETQKIMIQKTIILLNKINSSLNKTNTSTQETLDSIYPQIIKCLQILYLFIQVYDQKTSPNTHLMQILPLELQPHHFRNIDFNLVQIKIKNFHNKKILSLICYNHILLEHLFQAISTKFNLPQNYEWFSESLITFEQKQLSLREFSPNSIIEFQLKKVPKIEDKPKNQSMGFNFSQKFCGAVCINEEKKNDGKNFDINKTDRFPARILSSHENFSIIKSFLRSKSQKVSEMAYKILSELPSNFEEALPFLQMENQQKNIPFFVEEKTIKYENLSNEEVIESYEKTKQIQIQNQNQNQENYFEQIFLNEYSHPFELIYRLEHLNLFIFQTQILQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHR1</accession>
    <name>A0A9Q0LHR1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHR1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040466203" evidence="2">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="120" mass="13839" checksum="39D878A6C04166CB" modified="2023-09-13" version="1">MKFIFFILFFVIFTVSKTQKEIETKKLIYDFPRKIEPITVNKFLDKIGNSRVGGSWGDYWTADVWAAFFTIIVFIAFSLLGACCIMKIQIPRGSFLKSSREVLKIDSKSLSDKYSSRCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHY4</accession>
    <name>A0A9Q0LHY4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sit4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHY4"/>
    <dbReference type="OMA" id="NESYYGQ"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="699" mass="82287" checksum="1ADD84484C452E30" modified="2023-09-13" version="1">MENFLDIQQSPITKILEKGDFTLEELLDQEDIIEFCHFGFQDFSNFISSVENVSKILKYQLFPPDQNENDEKICRKYPFISSLVITSENFQIIETIANEKSLMDQIFSFLNNSPPLNPIFSSNFAKTILIQFRRKDEQTINYLLENDQILNKLLLHISDTNCADVLEKIIYLSVGSFSQNLTEYFDRNNLLSKLIDDLQTQDQNNFENTSRCLQSLFSLHLEYDTSLKKKMEDEELLGNLFNILAKKSSNKMDINRISVLVGILSTQTKSIIFQENEKIPFSLEFIMKNMDEFINQLFIPEPTMKLSHGEFEPFGKRKILVIHLLDTLLCIDYLPLQKLLIEKKIFSYFIDIFEKFPNNTFLHLQVSQIIIEILNSNLEIFIDHLFTETHLIETIISCCVVKSKESSGFLYHFFVISNEIIKLYDQNQKVKQILNNNEDWINFVQIEVYQNNQLQSTMIGEIANYLLPLNTEFLEDNEESTNLTQNEDVDNSNFNQTELSNPETENETFSFENVGRDYDYDYDYDDDEYNDEYNDEYNDEYNDEYNDEYNDEYNDEYNDEYEYPNAYKYEDEYRYKYGYNKYEKNQNQNQNQNQNILQKPQKPKSTPPTLFLKAKPPKPKSSPPPLPLKEKPPKPKSSPPPLFLKEKPPRPKSIPPPLQINSDSKQNSNENSNENLNENLNENLNENLKENLNENSKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI74</accession>
    <name>A0A9Q0LI74_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI74"/>
    <dbReference type="OrthoDB" id="49473at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040476757" description="Fibronectin type-III domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="231"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="396"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="500"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="743" mass="83426" checksum="C9C001F60A841D79" modified="2023-09-13" version="1">MNSKKVLFFSNIFLVFFIFEVLSLKEAKINEKKTEGKEIGWVIKQTLKENETNTTDQFSWGLSVSENKEYLVIGSPFAKIGNNSFQGKVYIYKFNGTNWNLFQILIANDGNQNDNFGSSISITQNGTYIFIGSPYAKIGENANQGKVYVYEFNGKIGIFYIFENNGTNWNLFQILIANDGNQNDNFGSSISITQNGTYIFIGSPYAKIGENANQGKVYVYEFNGKNWDVFQMINGSDGKDNDQFGISLSTSENQGYVVIGAPYASVGENPYQGKAYIFENNGTNWIESQILFASDGTTNGYFGYDVSISQNTGYLLIGSPTANVGDDWFQGKVYGFENNATKWLESQILIGNDLGWGHFGQTLSISSDGNDVVIGAPFATIGENCFQGEAFFFSYVPKPPQVDILNCSSLFCSFECYWNQVNPSSDEIEYQINYTLSPNWQLIESPILDENVLFQMFNSSNYENITGNVEYSIQIRACNKTTQICGFASKEVNLTTRIDSVKNFHLQAISGEVIQTSWTFPDVPIINSTPKLDHYVLSYQKENSNDSIKTNIWVVNSSTSCRIHNLQSLTNYSVSIYACRKDECFGEDEGQTISSSIETFFSSVINFSCSVSDLQDIFCNWKKPSDSTNSSYYNFTYKAISKNDSATFSINYTSFNFRAQYPDQEYRITVSACDENDNCGTISSIQLETQKKISSNSKTTKIVVGVVVPVVVITAIILIIILVRKRKKKIPPYFDEIDGDYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIA6</accession>
    <name>A0A9Q0LIA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIA6"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039588">
        <property type="entry name" value="FBXO4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008:SF4">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="680"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="855" mass="103652" checksum="F6BF32D738EEC7C0" modified="2023-09-13" version="1">MNSNQNKPLYYYEIIQIYLHLHYTTFINQIYPTSKANKMINYLEKYTQKNQYEIEEFTNKNVDLYSNINLDFIEKENEIEIENKREIEIEIEKEKREDENEDYFEWLPEEIILMIFEYFDKPSHLCICEATCSQFQRISNEPILWRNVLRKNAPFLDFLILAGSSYRYQTTVSCYFNFDGVIGICKYFEEEYERLLEQQKEEIYFDKKEEEIEKEKEKEKKPITDINDPNYDPLLDPNNPIYDPFYDQNNDSNDTFYHPNYRYNINPQNKDLKSKLYPKIKHDKYQQYFKENLQINQEVVDLIENNPKKLIVQQINKFESAYRVIKRDYKFYDSNPNPINSEKIDKALKIFEEGAIPILFSLSFLITIILSMLKLDLIIETNYVYIFLPVEIFFCCLLYIGFCFYLKRTNRHTYHFTISMIISIISTIIFLILLSIKLEYSNSFPWFIILIPHLTSFGAWIYFPVTIYRKIRDEEDYLINIIISYILIFHIPITIFMILFILYKQNISGITQNSIFIPLFIIDILPTALFIFWPIYLRYCRKHTDSWKSVRNLPSSYNSYLKINFISLFIYQIPMLILFIQELLIYLKLNQKIFIEWITVSIPSIITLGGILLFGTILEVKYIKRRHLYETSRYQRNINRNPNFIEEFADKNIDLYSDINLNFIENKTEKEKEEDEDENESYFDWLPEELILMIFEYFDKPSHLCICEATCSQFQRISNEPILWRNVLRKNAPFLDFVFITSYTYRYQTTRSFNFGFRGVIGICKYFEEEYERLLEQQKEEIYFDKKEEEKEKEKEKEEQKKPITDPNDPNYDPLLDPNNPIYDPFYDQNKNQNDTFYHPNYRYNINPQNKDLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LID1</accession>
    <name>A0A9Q0LID1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LID1"/>
    <dbReference type="OMA" id="EHRCMES"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="95" mass="11142" checksum="F833B9578EEB4E42" modified="2023-09-13" version="1">MSSYKQTVSAEERKKQSERILARFPDRIPIICDKNPKSDIQEIEKKKFLVPSDLTVGQFAYVIRKNIKLSPEKSLYFLSNNKLLSFDIILFIYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ93</accession>
    <name>A0A9Q0LJ93_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory-associated protein of mtor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="TEVCTND"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="117"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1093"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1311"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="883"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1439" mass="165058" checksum="972C74826C748FC7" modified="2023-09-13" version="1">MLKEKENKTIPEANNNNNNNNNDNNNNNNINNNDIDNNNDNNQNIENDNILVEKNLDDSNSIQNENQNYLENLEQNQKIIYFKSQIARIEKIKSKIYEKIEKVGEEDNEKNWRIQGRKKIKSAILSLCLHIGIDPPDVEKPDPCSILQCWINPFSLNEHKAIALIGETLEEQYKRLQPRIYYEKLLDPCVENLRKSCIQHQKYSQNERILFHYNGHGVPKPTKNRELWFFNKDYTQYIPVSIYEIFVWLGNSAIFVLDCTKADLLRSAFLSEENPFMNTKITEEKDYILLAPCQHDQELPVDPKFPADLFTSCLTTPIQIALRWHIYSNIYSKTLLNNIHVEDLDKIPGTLLERLSPLGELDWIFTTITDMIAWCSFPNDLFKKLYREDLLVAALFRNFLLAERILKSMNCTPFSIPQLSPTDQHPLWKAWDLAVDACIYQLPEFLSDPNYVFKPSSFFRDNVIGFENWIMFGTKIKYGVDLLPFLLQLLLSQNYRKHALHLIVKFMDLGSWAVYKALTVGIFPYMLMLLPTQELEIKMILAAIWGKILIYDKSCQIDLVKEKGYVHFIDLLSAPQLPPEIESAAAFVIALTLNNCKDAKIGCLNSNLLQICLSKLGEKSESRKWCSLCLSKLLEGYEKAKEKAISAGISDKLLKLLKDPNPIIRACSIYGLSNTISENIEEESRNSQEFSVSVSLLAAANDGSPIVRMELLVFLSKLISLHEEKVQQVALKIDEELIKFKKDPTDQIDSEHNTAIFSLWWKTLVKFSTDPYIEIQKISKDFITKLRYYWVPFGIFDSMRMQSSNPSKAQQNNRSLNSSTQNLFSKIPKSAYSILVRKENLEDLTIIANQQEILKNNQSNSVAKMLFQKDNLQNIEDVQINSNSKEISQDSPKNKITPKSSNHKLHEEKRKPRGSTKNLPKESRKARRGSSSKILDKNEQKENSQNNIESQSKDEDLTDETYKSTQVFAKSFTNFFAVDSFFETPNKISDKTPRENGRTLHNSLDIPNTEERIIPFKSTLFDFCVDLYSVPEIFQIKNNDLVFHSNTTSKINTPKNLRTQNIIEKTKNSMIENVKEIVNQKTKFQLNDQCALINSHTNKVSSVVFHPYESMIVCSDKKNQIFIWDWRKSSGKLVNQFNNGNSGQSRISFLSLINDLTPDPFVISGTTDGVLKIWKDCFSTKETDYPNHLESNTKNKANSRNSKNYPSLLSAWSMFPSYDNKKAITLESSAVFDWNPHNGLVSAFGENRVIKIWDVQIENEYQTLPTNSDRGLSCLKHDPKNPNILFGGSYNGNLLVYDIRIKSSGSLVHSFSEHSHTVLNICKQIGSEEVLISGSVQGDIKFWDLRNPYATKTLIAYQGLMTTLEIHDYSPLIACGSNNDFIKIFNTNGELINTVGYYDSFLSQKLGMVHAVSFHPYQMYLASTTDSLISVFTPSFLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJW4</accession>
    <name>A0A9Q0LJW4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_00881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJW4"/>
    <dbReference type="OMA" id="KVGFQGT"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040547954" description="Protein kish" evidence="9">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5074252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="82" mass="9567" checksum="1F3104F38544DB1E" modified="2023-09-13" version="1">MSALFHFNSMLIVILLTICSCAYLHQKFPNAFQYKEGFLGLLWKFARIGERLSPWVSLSCLFMGSAFLFSYLIQLFSFKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKM4</accession>
    <name>A0A9Q0LKM4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKM4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="154" mass="17652" checksum="650FAC5B2469AC3E" modified="2023-09-13" version="1">MKIKIHHQLEENNITLKETISPKETNKPTITNGRIGRNLPLKQETQNTNPLQNRINGRIGRRSPLKQDENQNTSPTGRVGRIGRTTGRIGRRSPLKQDENKTISPKETISPKETTGRKRKKITKKNKKKKKQNPSPITISRIGRITKKKQINQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKV4</accession>
    <name>A0A9Q0LKV4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5073010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKV4"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="183"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="289"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="454"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="559" mass="63118" checksum="CCF303D1B480370B" modified="2023-09-13" version="1">MESEVFFFGQNKGFQVKENAMTPTKLTQFDEYGITQISSGDFGTLLTTTNNQVIWISRSLKDTLNHSVIQVSVGFSVAAFLTENGEVFGIGNHLGAEKNKFIPISPMISLDKNETITQIACGVYQLYLLTSKGIAYGMGDNSCKQLATEDVTKQTKPIKMMENIESIYTGNYSFSAFLLTKNDELFALGQNSSYQLGLGDDNNDIYPPQLVKTRPEGEIRQLVIGYEHSVMVVEQKGKGQAYVSGQHSYNGLGKSDSAKLFTHLSSLSNSDIIQIDVGCFHTLLLTAENEIFAYGINPYGQLGNGSFSSTDMPIKIEIPGITQELSKYRVVAGSFHSLVYLPVQKLTTIQEDFIEFLNNQEACDLTLQALDGSIGVHRLILELRIGKENIQNFQYYIKSKNLAETNSILKFIYGCRFLQKKLMRELTEIIPNLAITKKQFSEQLTKLKNANESKDFVVKFENNHFRIHKTILWARSLLFRGMFLNVNDSSNEVSNYCEISLDAFKIFLDYLYTDEIDTQIKFTKQIVEDLAKAMDYFQLNESEPNLATKALRKFEENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL88</accession>
    <name>A0A9Q0LL88_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fch and double sh3 domains protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL88"/>
    <dbReference type="OMA" id="TRAGEIN"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="286"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="363"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="68"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="418" mass="49420" checksum="1CF8B11B5CF48C92" modified="2023-09-13" version="1">MNTFNELDNSINESFLKVKRIQNAFQSILGFEKEYQIKMIKLQSQLNKKLQIEKNEKNISSKCWNSIINENERSITHLNEKNEILQNQIEKFPQVLNLQDKIQQILDNIQIAKQNFEKAKNDYENFENNFSKKQNEVTKIEKELEKNKSREKLQTKLGSLRKEEEETRNAYLKSHESVTLQQEKYKQLVLESINQLRELEQEKILKTQDLICDFIKTQENYILSLKQSNLDLIQNLQFQEDELDKYIQSSFILDPLAPLPEIENYENFGNENQNSNENQIQIQIQKQNQFAKALFSYKAEQKQELSFEIDDMIKIIRKSNDGWWIGEINGIQGMIPEGYIEIIDSNNQNNQNNQNNNNNNNQEIKRKVEVIFDYEAKDEDELSIKVGEILIILKEYEGWFQAQNKLGKEGLVPANYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLH0</accession>
    <name>A0A9Q0LLH0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLH0"/>
    <dbReference type="OrthoDB" id="10691667at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040406494" description="Fibronectin type-III domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="856"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="467"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="905" mass="101981" checksum="032616FC806D723A" modified="2023-09-13" version="1">MKSILFFSFYFFLIINIFLIQSNQNQKSISSLISPILTEIKTLTETTRYYSTPDEAWIWNLLDQFPSSSGYFGFSVSIYKDVLVIGTRYLNQAFIYRYNGTNFELEQTLNESSVTHFGISVSVYEDVTVIGADYANQVFIYRYNGSIWNEEQILNESSVTHFGISVSIYENVTVIGADYANQVFIYRYNGTFWNQEQILSEPSALFFGYSVSIHKDVIVVGAYGANQTFIYRYNGTFWNQEQNLNESASYFGFSVSIYENFTVIGAYGANQTFIYRYNGSIWNEEQILNESSALNFGRSVSIHEDAIAIGASAVNQVFIYRYNESIWNLEQILNGPASNFGNSVSIYENFTAIGAFGANQAFVYEYKLIPQVNIVNCSSSFSSFDCYWDEIQITTLEYQINYGYDWIDIDSPILEDENVYYQQFNSSFYDNITGNEYYSIQIQACNNVSMKCGESSSLINLTTKIDSVKDFQLSNPSNNSINVTWNYPNVQINEGIAHLDHYNLSYFNQSQPDLISFISVDNSSLDYLWNNFECENDYNISICGCRTQECEGDDKGEIVESLFPLLFGEVTNFSCSISKLVDINCNWNQPINCSIPFYYNFTYQSISQNDSGNYQPTSSNQQFTVQLPNQEYQINISSCNSNGKCGYTSSISITTDNFTIAPTIYETISKTEEIEFNFTKLTNANNYSISLNNGTNWQNFTSLNLSGNEVIGIISGISGNIEYNISIRGCIDLNCETPYLGLPSSIISTRAKLGNITSLNCYAINYGFVCTWDALILSSGLARYLFHYGIVSICLPKSTNFYSASGLNGEEEYVIWVVASADENCLGSEYSGINSTTSLVPSIPTQTSASSSKTPIIVMGIVIPVVVIAAIIVVVVLMKKQKNSIKRIIKKREKELEKSGGIEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLU5</accession>
    <name>A0A9Q0LLU5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="EGTKTWK"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="42"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="277"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Ataxin-10" evidence="4">
        <location>
            <begin position="556"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="715"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="885"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1147"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="1152"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1323"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="domain" description="Ataxin-10" evidence="4">
        <location>
            <begin position="1382"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="domain" description="Ataxin-10" evidence="4">
        <location>
            <begin position="1524"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1585"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="1632"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="domain" description="Ataxin-10" evidence="4">
        <location>
            <begin position="1827"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="1984"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="2160"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="2289"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="2325"/>
            <end position="2492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2541" mass="292268" checksum="050E262EC18E698B" modified="2023-09-13" version="1">MNQENQIEIENQIEMENENENEIEIENENENENENENENQNENENFLNQFIEAQKQIQKLEKELKEKQIQIQIYKSEQKAQFFLQEFRNFQEKEIEKEIEKEIEKEKIQREIISIEESIQWMKNFPNNQNIQENGFFTLYKLLKKKNENETQIHHLNLFQIITRSMNNFPKSKQIQVPALLILIDILQFPEKQAKFGKFQVISRIIKAILNFPIDNYIQENAFFALTNIPLNIRKFGKYKGIKAIIKSMNNFSHNQNIQEYGFEILMNFPFKKSGIEIIIKSMNNYPNNEKIQEYGCNSLRKNISYKQKENQIEIRNIKGIETIIKSMNRFPDNQKIQEYGCEILKVMSLKNQKNQIEIRNIKGIEAIIKSMNRFPDNQKIQEYGCDILRIIPFKKKEIKNMNGIETIIKAMNNFPTTKSIQENVLQILQYISLNNIENQNEIKKLEGIEKIIHIFLTFPKNKQIQEMVFKTLSNICLENQENQKEVNKFEGIQKIIESIKKFYDPNLQKQAISTLGIICQNNEENKNEIKNQGGIETIIQSMMNFSLNKEIQEIVLQTLEIISFKNKENQNEIRKLKGIKKIIKSMKKFGDQKSLQKQGISTLRAISSSNEENQKKILKFKGHQLVNTIMNNSPDDLFIQQKGIKILYIHFINHKKNENILKDSSMIITFMQAILKIQYKKKIHEDYFENLLSIIEQNKENENENEMKNLPLIDKIIMLMNQFTKKEKIQENCCRFLILYFNGENKDSKIEMKALEGIEVVIKAMNQFFNNLQILINGIQILSFVVEINNAIANTKGIEVIIKIMAKFNDQEKIQESCLKILSFSSITYQEIKNMKGIETIIKAMNNFPTNGNIQENGLNILSKISNKNKENQNEIKNMKGIGAIIKAINNFPNNENIQSNGLLSLANISFENKENQNEIKNMKGIGAIIKSINNFPNNENIQKKGLLSLANISFKNKENQKEIKNMKGIEAIIKSINNFPNNENIQEKGLLSLANISFENKENQNEIKNMKGIEAIIKSINNFPNNENIQENGLLSLANISFKNKENQNEIRDLKGIETIIKSMNQFENKENIQSNGLLSLANISFKNKENKIEISKQKGIEIIIKAINNFPTNGNIPSRSFIILKNILLENKEEENQNEIRKQGGIETIIKSLNTDKNNVNIQENGLNILENISFENKENQIEIRKKGGIETIIKAMNQFKKNRNIQSQGVLSLRNISFKNEENQIEIRKKGGIETIIKAMNQVKKNQNIQEKGLLILANIPFENEENQNEIRNLKGIEIIINAMIKFGKNENIQENGLLSLANISFKNKENQNEIRNLKGIEIIIKLLNNFPNNENIQENGLLSLANISFENKGIETIIKSMNNFPNNENIQSNGLLSLAYISFKNKENQNEIRSLKGIETIIKLLNQFEKKKNIQENGLLSLANISFENEENQNEIRDLKGIETIIKSINKFEKKKNIQENGLLSLANISFKNEANQNEIRDLKGIETIIKAINKFENNENIQSNGLFSLANISFKNEANISFENKENQNEFRNLKGIEVIIKSMNNFPNNENIQENGLNVLSNISFENKENQNEIRNLKGIETIIKAMNKSPIKENIQENGLNVLSNISFENEENQNEIKNLKGIETIIKSMNKFPNNENIQSNGLLSLADISFENEENQNEIKNLKGIEIIIKSMNNFPNNENIQENGLLSLADISNINEAIQNKIRNLKGIEAIIKAMNNFPNNENIQSNGLLSLADISFGNKENQNKIRNLKGIEIIIKAINDFPNDEYIQENGLSSLAYISFENKENQNEIRNLKGIEIIIKSMNNFPNNENIQSNGILSLACISFENKENQNEIRSLKGIEIIIKSMNNFPNNENIQSNGLFSLANISFENKENQNEIRNLKGIGAIIKAINNFPNNENIQSNGLLSLANISNKNEENQNEIKNLKGIETIIKSMIKFGKNENIQKNGLLSLSNISNKNEENQNEFRNLKGIETIIKSMNNFLNNENIQSNGLNVLSNISFENEENQNQNEFRNLKGIEIIIKAMNKFPNNENIQSNGLFSLANISNKNEENQNKIRNLKGIETIIKAMNNFPNNENIQSNGLLSLANISFQKNQNEIRNLKGIETIIKAMNNFENNENIQENGLFSLASISFKNEENQNKIRNLKGIETIIKAMNNFPNNENIQENGLFSLAFISFKNEENQNKFRNLKGIEIIIKAMNNFPNNENIQKNGLLSLACISFENEENQNEIRNLKGIETIIKAMNNFPNNENIQSNGLLSLANISFENEENQNKIRNLKGIETIIKAMNNFPNNENIQSNGLLSLANISFENEGIEVIIKSMNNFPNNENIQKNGLLSLANISFENEENQNGIISKDIIEIILKPMNKFLNKENIQLNGLKILSKISFENEVQKENQNEIRNLKGIETIIKSMNNFPNNENIQSNGLLSLANISFENEENQNEIKNLKGIEIIIKSMNKFPNNGHIQSNGLLSLATISFENEENQNGIISKDIIEIILKPMNKFLNKENIQLNGLKILSKISFENEGKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLW7</accession>
    <name>A0A9Q0LLW7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glyceraldehyde-3-phosphate dehydrogenase [NADP(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Triosephosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + H2O = (2R)-3-phosphoglycerate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLW7"/>
    <dbReference type="OMA" id="VAACFRF"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008886">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008911">
        <property type="term" value="F:lactaldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051020">
        <property type="entry name" value="ALDH-related_metabolic_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42991">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42991:SF1">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="500" mass="56136" checksum="8441BB6ECA2F4312" modified="2023-09-13" version="1">MDLIRKQTIKKEVYPLYIAGKQVMTNKFLDVFDKFTEKKIARVSLAEKKEIQEAITTVSKSRKAMNDLPIHARKDILRDIAKQFRERKDELASLITMESGKPIKISQVEMNRAIDTVENCSEEAGRNYGEYQDFGYTKSSQGYQGTTRRFPIGPIAMFSPFNFPINLIVHKIAPAIATGNPFIIKPSPRTPISAIVLGDILANTALPKNSFSVLPMENNLAMELLKDDRMKMVSFTGSDVVGWKIKSLSGKKKVTLELGGDAACVVDKCNCAETDLDTIAKRIIFGAFYQAGQSCISVQRVYLHDTVYNKLKERLIHFTKLLKTVDPMLPDENPLEWNVGPLISTDEAKRVESWVENAKEKKAKVLVGGQRINNFYLPTILEKIHQNSIIAQNEVFGPVFYIEKFSNMKGVITKINKSRYGLQAGLYTNNLKRAFSFYENVECGGVVINDIPSARVDAQVYGGIKDSGMGSEGIRAAMHEMTVPKIMLMKDYGIPKLKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM52</accession>
    <name>A0A9Q0LM52_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM52"/>
    <dbReference type="OMA" id="NIENWEN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="225" mass="26900" checksum="1A23590A854467FD" modified="2023-09-13" version="1">MNPINEIINQILINNDKPKPSRLRSQKISHPKILHKNSSKLRNKKIPNNQNNQNNPNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNENNQNNQNNQNNQNNQNNQNNQNNQNNQNNENNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNNQNFNFENRFLFEREREFFLIHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LML7</accession>
    <name>A0A9Q0LML7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LML7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="131"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="429" mass="51143" checksum="BE668B54C28116E2" modified="2023-09-13" version="1">MSDSSKEIDSNQKSNKKSNQKSNQKSNKKSNKKSNKKSNKKSNQNQKSNKKSNQKSNQKSNKKSKKKSKSKSNQNENQIQKISFQEIYSKEKSQKIQISKLYQFPPQELNKFLICELLSNYKKMFQNEENCDFIIYAGKNNQKIPCHKSILNSRSRFFYENHHEKSEIEELYLPQFEYDIVKSIISFLYDSEFKFDLNKFEKYFQLSKDFKLTSLTIKIEKEVSEQINKKNVIPIYFKSISIESNYLSNICENFIKENINKIIEEKQIGSINNKELTEIIQIIQSTPKENRINLIWKLAQDWKNKFKQSNKNLINKEKYIDPIQIQEINNEIQDFHLIIDNIKNEGFILNYSRTQNNPILPPTDQLQLINQKNEELNQENKKLKKKIKRQDKIIQQKDKEINQLKQTIKQKDKEINQLKQTIQTKRSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMY7</accession>
    <name>A0A9Q0LMY7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMY7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="115" mass="13887" checksum="4AD23FEF67486B21" modified="2023-09-13" version="1">MEKINNLVFKLSKKKINSIDLFHQNLFLENNFKNFFQKPKSRNQKLSILKICNKVESNWQKWKNSINMETKLEELNEKFPLNKEQFISELLTKNNFPKIEEIKNSKIKNLEIFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN15</accession>
    <name>A0A9Q0LN15_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein sey1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN15"/>
    <dbReference type="OrthoDB" id="2343366at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="379" mass="45552" checksum="6FA7ED81017235E1" modified="2023-09-13" version="1">MESNEFLEIINSRRNQNRKEYEIEFRYISEIFPIQNLETITYENALIFFSNKIKFRPNQIKFFIQKIPLLEKRTLLESIEDCIRKLSEKDKKISKNHYIIDIKVDSDISKQRRRRQEQEQREQEEKRRREEEERKRREKEERERDKEKRVYCGYVCKSCHYSCTLQKGHKGLHSVQHGNMRYSTLVTEKGKNGIESEEYHLKTGESSKQIICTHQCLLGGRGHIHLIPLDEINLNKVPQSFRKLIRYSDKEYSDNVQYYEATCHFYWNFYLKFKSGFSKEQEFEFSRCGAICGAEIHENHQSHSHEKKLKQVHALEFLGRKTENEEIPYCVLPLWHSKWIPNQFPKGYQQGFTSREGHFFPCNHGREFDFGKLSSLLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNV7</accession>
    <name>A0A9Q0LNV7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNV7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18752" checksum="8A2423255E70CAA7" modified="2023-09-13" version="1">MGLAKLKILMNLLKSNHIYLKMMIIFLIFLFNEDIYNYHLSCGYNKSFIYYSPPSFSNLEEDLIKLFKRKEFCNISFKTENGEIISAHKLILETIIGQDENQNEKLKEIISNKSIKESNQIFEIIYSNNFKINPKLYEEIEIDMNLFGSIEEKMKRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPC2</accession>
    <name>A0A9Q0LPC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beach domain-containing protein lvsc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPC2"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Neurobeachin beta-propeller" evidence="5">
        <location>
            <begin position="110"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="357"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="427" mass="50063" checksum="46B503535F34A7EE" modified="2023-09-13" version="1">MLNFQIGLKQQKNLFKYKKKHLNQNISNPIIFTKFQEIPEKATLMKPEPDQIITINKERIIGKHKFYLIESKNKKPKINLSIDDEKYKQNQKEKIREIPFSKDLNNFEECFKNYENSKYFIFCGFEDNSFKIIDIDKYEIIQNIYKHNDIISCLDIDLKYIVTGSKDTTVIIWEIESKEKKGKIKVKEKPKYIFSEHEEEKGKHIQTIITEEKEPITNIKITKKGDIITFSENSNILRLFTINGYLIRRFQCSENIYSISISEDSNFIFTGGEKGIFEIRKIFNLKPIQSFDLNETIYSISIIKKGFLIIIGLKNGFIKIGYFSNTTQNQNQNQNQIQNHNQKEKEKEKEKEKEKLNSNSKSKSNSKSNSKLKLKSNSNSKSISKSKSKSNSNSKSKLKSKSNSNQNQIQNQIQIQIQNQIQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPD7</accession>
    <name>A0A9Q0LPD7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btb poz domain containing 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPD7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="298" mass="35329" checksum="52059D5D28BDCBE1" modified="2023-09-13" version="1">MNCPVCQIDLSHLNQNQIESHVNQCLDNQIQNENQNLIENQNENLIEIQNEKIICQFCQKDLTDLHELRRREHLNRCLDSWEGKKKIQKDFENLVETEAQISKNQDLIFNDLNFCRVCGKSLEHLEMKERTFHISNCVRSSNLVSCSVTKIVDGVVQKNNTNKTDQDQKVEQRKDQKIRQRTPKLKRVPSSNRKRKSDGKKKKSNDLNQDLSSFEKEDIIVAHILSKSELESFKEFNNSIDLNNIFIENQDLKLNKNDLKKYNQNYFQKINQKIKLFTNIKFKVLQKDGFWEKTRKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPP8</accession>
    <name>A0A9Q0LPP8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Presenilin</fullName>
            <ecNumber evidence="8">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_07709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPP8"/>
    <dbReference type="OMA" id="NATCNQQ"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5075005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="437" mass="50894" checksum="2A3EC1FA42F9A6CC" modified="2023-09-13" version="1">MTNQNQNQNQNQNQNINLNQNLNENQNQNQNQNQNQNQNINSDEILFRQSEYLMRKFQPTLFIELISKKLKWVLIPVSITMILVAFFIESIYISGENSNGSPKQGFNSIPVFKSNLNNSTNNFNLNDWELALFIVGLIFATTIIFLILFKLKCYKILLYWLILSTFGMLLFFSASSFLDILQIFNLGIDWISFVMLIYNFSVVGILTMFWHGPKWISQGYLIIFSVLLASILAKLPKTTNWILLILISFYDIFAVLSSKGPLKMLIDEAVKADQQLPFLIYSSAAWIFSTNFDKENNPKKKEKENEKEKEKESISEDENEELRRLIVRPINEFDLKNENNQEFIQNFSESRIKLGLGDFIFYSLLMSLACFSSYLTVFITFIGILTGLTITLFFLVVYEKALPALPISIFLGIVFYFLTDLILNQFKEKYEQSWIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ77</accession>
    <name>A0A9Q0LQ77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylate kinase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ77"/>
    <dbReference type="OMA" id="HYKVDAA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="222" mass="25262" checksum="E073D30FAFDB713B" modified="2023-09-13" version="1">MEFKKFLSFLGPPGCGKGTQAPKVTDKYQLQFLSTGDVFRQAIKDETDLGKKAKDFVSNGKLVPDSIVIDMISERIFEEVKKTEGILFDGFPRTYTQAIALDKMLQKFRARVHAVISFDVPDSVLFERITGRLTHIPSGRTYHKTFKPPKIPMKDDVTGEDLVQRKDDTPEYLTRRLKEFHENADLIKDHYRKLGVLISVNANQSINSVTNEVLTSINKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQB9</accession>
    <name>A0A9Q0LQB9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQB9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="214"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="275"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="331"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="502"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="607" mass="70846" checksum="0D866B0B262EBAC4" modified="2023-09-13" version="1">MNDCLFFGENKDTKLIKNEPNIITKPIQLKFENENENENENENENENENENEKQIKQISSGFFSTIFLFKNGKAIEYLNENDSKQNPSKIQIEENIQKVTVGYRNEAILTIEGNVFAKGKDINPNNPNEFINVSSLIEDQNDRIIEDIISGANAIYLLTSNQNTYGIGSNSNGQLCFDSKTLPKTEKPILMMKNVSKIFSGNCSFHVFLLNSNQELFGYGDNIFGQLGLGESRREVKIQKLTKIQNIPKGKIIDIKYGYVHSIMLIENENENPKRKLYSCGYWKYNGLGKEDEDENTYEFTEIKSSLFENDDNILDFSVGDNHTLILTSNSKLIGFGYNEYGQLGTGDTNNQLIPIQIELPKLRFNGNISNYHISCGYFKSFLYYSPFFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQNEIEKLQEIISNKSIKESNQIFEMIYSNIIINPKLYYEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR11</accession>
    <name>A0A9Q0LR11_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR11"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="715"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="812" mass="95720" checksum="081EF9A6BA77E7FB" modified="2023-09-13" version="1">MNQNEKNRKLFSACQNGSIKEIKTLIENGADITIKNSIFQTPLHLICKFQKKEDSFEIIKYLIEKGLNVNAKTFANETPLLLFCQNQNKNSNSFEVIKYLIEKGSDLNQKTFANETPLLLFCQNQNKNPNSNSFEIMKYLIEKGSDLNAKNTNNETPLHLFCQNQNSNSFEIIKYLIEKGCDLNEKNNKNETPLFYSFQYYFQNQNSNSFEVIKYLIEKGCDLNSQNNKNETPLHLVCRNPNSNSFGIMKYLIGKGCDLNAKNKDNETPLFYSFQYYFQNQNSNSFEAIKYLIEKGCDLNSQNNKNETPLHLVCRKQNSNSFETIKYLIGKGCDLNAQNKDNETPLFYSFQYYFQNPNSNSFETIKYLIEKGANINAKNNKKETPLHLVCQNQNSNSIETIKYLIGKGADINAKNQIDQTPLHYACNFRKETQHQNLVEIIKYLVEKGADVNAKSTDNESLLHYFFRNQYSQDHEEKLFEIAKYLVEKGVDIDLKSKNSGIVLFLAKSRKYFKLVKFFMMNDANLFHLPDRENIQEIYEFFPKIYSFNEDMNNLLKSTDFSDYQIESKDFFKFPVHKSILLSRFDNDEKTLQNFVDICQQKPKEIVQFALNFLYTGFPDFDNFATKFSTFNDLCNQFETLRNERNSYRIEWSDFEKRRKEILIPIKNIKKNDQEKPIIEEFFKELGFDSEWFESKKGRKGILKDFDKLYQQNETKDFAIICEEDEKEIKVHKLVLIMRSELFKGMFLSVEDSSNQVHDYSGKSFETIQELIYFLYHDEFEKEIKQEIIEEFEDLKDYYQLNQNSIIDLIFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR39</accession>
    <name>A0A9Q0LR39_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR39"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="381" mass="43710" checksum="D8E6B5FDA618333C" modified="2023-09-13" version="1">MNEILFFGQNQLPKLIKNEPDKIKKPIQFKFENENENENENEKQIKQISTASYSIIFLFKNGKAIEYLNENNSNQKIQIENIQKVAAGYLNIVVLTKEGNVFARGEDINPENSKEFINISSLIEDKNDRIIQDIVSGYKSLYLLTSNQNAYGIGSNEYGQLGLDPETLQKTEKPILIMKNVSKIFSGNTSDSVFLLNSNQELFGCGDNQYGQLGLGESRKEEKIQKLTKIQNIPKGKIIDIQCGGFHSIMLIENENENENPKRKLYSCGDWEYNGLGRFRYTYEFTEIKLSLFENDDIILDFSVGNDHTLILTSKAKLIGFGDNFYGQLGTEDANNQLIPIQIELPKLRFNEEIFNYHILCKNERSFLYYSPPPFPILKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRP1</accession>
    <name>A0A9Q0LRP1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic initiation factor 4b-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRP1"/>
    <dbReference type="OMA" id="YMNALAM"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="79"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="23247" checksum="CDE525EA043D73EF" modified="2023-09-13" version="1">MSFQQTEKSNQSSPEKEKEKEKEKETTKTQKKDSKEDEDTKQKQKDGIFDEDEEEKFQQLQEESIKLNQPNSDSPDDSKSIFVGNLDPSTTDQELYDLFASCGPIRKLTIRKNKMGESKGFAYVEFENLDSIETSLTLEGTTLRGKNIHVSQKRTNVPFSKGRGRGRSRGRGRGRGGRGRGRGRGYSWQPRGRSRSFHPYQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS29</accession>
    <name>A0A9Q0LS29_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prp40 pre-mRNA processing factor 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS29"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="322" mass="38113" checksum="5E83AFAE18098157" modified="2023-09-13" version="1">MTSEEFDFCYELYDIRYKHNYYYNPVTQDVSWNKPDNTIIALSVVNEIRSGYRNEALHKIKKFEQEHFPDLVIPETHEEKQEEQEEIVPDGWIKQIDPNTNRPYYVNIITKKSSWTLPGADINQENNSNENHFKGIDLNGNDSNDDSKENLKENLKDDSKENLKENLKENLKENLKENLKEKDLKENLKENLKENLKENLKENLKEKDLKEDLKDSKENSNENLKENLKDNLKENLKDNLKENLKENLKEKDLNDSKDSKENDLKENDLNDSKDSKDSKEKDLNDLNDLKEIDLNDLKEIDLNDLKEINLNDLNDLKENENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSD2</accession>
    <name>A0A9Q0LSD2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_05381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSD2"/>
    <dbReference type="OrthoDB" id="28697at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF263">
        <property type="entry name" value="PLECKSTRIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="296"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="5">
        <location>
            <begin position="757"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="935" mass="110348" checksum="C0A51F3EB59FD465" modified="2023-09-13" version="1">MSDLNEEKKLLKKINKILSKKNLKIKSIEKGCANGVCFIILLQEITKKKFDFFSKPKSIEEKTFNFQIILNFFQTHGFKNLCKIENLLKGEKKYQMEILNLILNQKNLPQRRHTIQLERFISTENLNENQNQKLNKNQNENLNKNENQNLNKNQNQNQNENEIHVTRTVSTSVITKLNRDEKIKLSQRRRINQPNLINKVEKLNQGEEMNKSKEFSDLKELNQSSKSRRSHKSHRSFDSDQNTKKNTKKNTKKNTKKNTKKNTKKNTKKNSMEIQIENQIENQNENQNQIQNSFDKRHSIINEIYETEESYVSNLNKLIKYYLEPMNKLLNPDQIKIVFSQIETIARTNTFFLKRIQERWEKWDKNSLIGDIFQEMATFLKSYNQYIADFNVGMKTLSDLKTKKEISSFLEKQTKIPELNKLDISSLLIMPIQRIPQYVLLLDELLKHTDKNHEDYPKLTKASEEMKKIGSFVNESKREYENMIQVYKIKDKISGIDDICIPSRRFVKEIMIPIIWKNRKYKGNVFIFNDLLIAGKASGSKAIYLTQFSLDASIEIKIAKELPNLKSKKVFPETAIPVEMINTNNKEDKLIFITQNEKEYVQFIHLVDHHIYLNLQDSIEISKYKEENKEKMENLEKLEKLKHPPFKNVFIYIDKEKDKRKFRYLEIGYEYISVSRLAGDSNKKNKNKNKKKDQESKKEDSAMLIINCNMELDHEISGIKLKTPTKEFLLTRRNINDALQTVNFFRISLFNLISNERSVLTGLSYGEVYNLDLKMNNFVSLHNQKCFDCDGREIRFASLFLGVFLCFECARNHLKNGEYSNIKPIASLNQEEFKFIDSFSNSKKKSCWESNLVSGKPDSSSSREKRKQYFQSKYIHKLYYSSPSVSNSKKDEEISFDSGNFDFDDLDLKNTSIKQELSFDDFEEFDFEEFEKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSS4</accession>
    <name>A0A9Q0LSS4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSS4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="68" mass="8285" checksum="C1950929D6A67C9A" modified="2023-09-13" version="1">MRITDYSELSNKSFQIFEYWIYSNQIKNEIEITQEMINEIQIGIDYFQLNETNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTX2</accession>
    <name>A0A9Q0LTX2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btb/poz domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTX2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF4">
        <property type="entry name" value="AXUNDEAD, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="45"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="582" mass="69607" checksum="C329C5249FEE30EA" modified="2023-09-13" version="1">MEEKEKEKEKGKKKKEKIIAKKKFTRTRKLGFELYLTIFNPYIQHNFTIITKEKKKLYVDSIILSSRSPALSAQIDRKNQLKLDNNYFVVKTALEYIYTDHFQLPIKDLEDDSPDSFGLTCELYQLFDKWILPKAKLKCENFILAELSYIDPELIRQIEENEITRAEAFRTRVLQNFDFVRNISDDLAQKALHIIDVQFPTIYRLEDYLHLDDIDFKMILHRNTLHIPSEKTLFHIVVNYALYKYNDNKPVTKNDSPFEEKESNGKNELRRKLRENLIKYIRFGVMTIEEMENVKEYKILTDKEIADIEDYIENKSKKKSKIAAIVEKYNNQGNEWFKDKRFDFNQEIYLDQKMKTYVKRNPVVKLDKKLSPEDILHEKKDYFSDKIKEEILNNFKLQFVSTKDDNLNCKEFHEICDNKAPILIIIQSKTCIFGGYSSVGWLTKEVEEEKKKEKKREKKREKKREREKEKEKEKIPLFNDKMRFIEDEDAFIFIIKSINNEQYQFKIIPEKKETALVYYSKRGPIFGRGWDLSISADLKTGFSNLGYNYQLPDRMKVKSKEAKTIFNGQYGEWNIDKLEVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU62</accession>
    <name>A0A9Q0LU62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000039">
        <property type="protein sequence ID" value="KAJ5079097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU62"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="202" mass="23862" checksum="701C77B58B39372A" modified="2023-09-13" version="1">MRMKNKNFFLFLKYFFFRKIRDWGEIFLFFEINYSRFRLTEDEIIIHSIVSKSFLKSKIIQIKREINQIKSINQSENQSENKSENKSENKSENKSENKSENKSENKSENQSENKSENQSENQSIYFSKDHIAYFVVFRVNAPMSFNFTSPNAPAFGLSATLRRGGSVDDLGLYTKTTNVAFLIYFFSLLFLYCSILIRIINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUJ5</accession>
    <name>A0A9Q0LUJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fimbrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000034">
        <property type="protein sequence ID" value="KAJ5079192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUJ5"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21218">
        <property type="entry name" value="CH_PLS_FIM_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21219">
        <property type="entry name" value="CH_PLS_FIM_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21220">
        <property type="entry name" value="CH_PLS_FIM_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="253"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="403"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="530"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="649"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="138"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="762" mass="87057" checksum="C60A83289CDCD8A8" modified="2023-09-13" version="1">MQNLNPFLLGKNSKKKSQIEDEENCFLKALENGISGFKLGTFCGGIFGLILTFADHQQQSPKQRLLSVIKSTTKEAALQGIGFGFSSFLYSLIDCPLEKKNQQKTNELVPKNINYQLFSRKFCMKEEKVVDNLNKINYESLKKQIENGKRREEELIKKISQLEDEKKNEKEKLDFQETMSSLNKEYAKKIEDLNQKIQNLEEENKILKEKLEFSTEIIATDKEKGEEIEEENAKLKETIENLKGKIESKRSVDLLEKELVGYINLRLKYDRDLINILPIGTKSADLLEAARNGVLLCKLINDSFPLTIDNRAINYEINEESSLENHNLCLNSAKWIGCNVSEIEPQSLLNGDESSILQLTWEIIKLGLFSNLKIIKHPEIVVLFDENNKKGLSQELIDEINKIPPENILLKWINYHIHRAGEKRIIQNFSEDLQQPIVFATLMNQLSPQLCPLAEFAKETDPDIQAKMIEKFASNLDCKQFISAQTIMSGKYDQLNAAFLALLFHTRSGISISKEQAQKIVFDDHDRAGTREERALRIWINSMGIQPKVYDLSKDLRDGLVILKVIDKIEPNLVNWKKVNLVPNDVFKKLENCNYVIELGKSLHLHLINISGENIQEGNKTLILGFVWQAMEYHIKTILTKLNVIQSGRITDKDIVTWANTKIESAGKQSSIPNFKDRSLQNGIFLIDLVYSISPKAINYNFIQSGNSDEECMNNALYAISLCRKIGASIFALPEDIVEVKSKMILIVVGELMRIDKLINQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUR2</accession>
    <name>A0A9Q0LUR2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUR2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="219" mass="26389" checksum="34633E045368C302" modified="2023-09-13" version="1">MKSNNQKKRKSDKKRSSNFDTFDFNPEIKRREKSNKSKENQNQNQNQKEIGLENKIKLDEKTEFVNQFSNISFNKNKNKLFMNKNMQEKEQEFENENENEHQKILSKFKSFGNHFNQHFPELTEKEWEPNTERVFINNLYNSSNQLIQNPQIQDENLPEKKIQSKNQKEKKTLAIIPYVSITRTVYESIKKNHNSNEENSNEENSEKNSEEMWVEQDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV68</accession>
    <name>A0A9Q0LV68_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein tem1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000031">
        <property type="protein sequence ID" value="KAJ5079507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV68"/>
    <dbReference type="OMA" id="FDLNCTI"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="194" mass="22012" checksum="6729F526ECE60C38" modified="2023-09-13" version="1">MSDQHSSVVVKVGMLGDAQIGKTSLMVKYVENTFDEDYIMTLGVNFMEKTIQIRNTDITFSIWDLGGQKEFVNMLPLVCNDAVALLFMFDLSRKATLSSIKEWYRQARGFNKNAIPFLIGTKFDIYAGYAPEDQKDITKQARRYARAMKAPLIYCSASCSINVQKIFKIVLSKVFDLKCTIPQITGDDEPIVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVQ0</accession>
    <name>A0A9Q0LVQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVQ0"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="459"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="632"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="757"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="854" mass="98808" checksum="56A3DC3CB1BEE687" modified="2023-09-13" version="1">MNIWEAIKKNDIKYLKQIKTLSQNELIKEKENKPILHFAIENKVSKQIIQILISKGAKPNSKDNLGRNSLHIACLNINISIEIIEYLIQKGVDINSKTNQNQTALHFVCENLNPSFEIIKYLIENGIDINAKTRYSNLTVLHIACENPNISFEIIKYLIQKGVDINSKTKGNETALHIACQNQNPSFEIIKYLIENGIDINEKTNKTSETALHFACLNPNISFPIIKYLISKGIDINAKTKYSDSNALHIICQNENPSFKITKYLIQKGININSKTNNINDSALHIICRNKNPSFKIVEYLIEKGIDINAKTNKTNETALHIACQNPNPNSSLKIIKYLISKGIDINAKTNKTNETALHFACSNPKFSFQIIDLLIENGVDINAKTNQNKTVLHTACEIQNPSFKLIKYLIEKGVDINAKTNQNKTVLHIICENENPSFEIIKYLIEKGVDINTQTNYQNQSVLHIACQNQNTNSYFKIIKYLIEKGIDINAKTIENQTALHISCKNQNPSLEIIKLLIEKGIDINVKTSWGNQTALYIACKNQNLKIEIIKYLISKGVDINTESEYNNQTALSISIHYKRKDLIELLLMNDANILNLSKNRITNRFIEIFLKIYSINQDMNNLLNSNENFSDLTIQSNDEFKFNIHKLILLTRFDKNETILQKFIDICFQKTKEDIQIILNFLYTGFIYFPQIYQQLNQKVNINFLQIKNEQKEKEIKLIEFLNEIGIDSKWIEIKKGRKGIIKDLSKLYEENETKDFTIIISNEKQIKVHKLILFLRSELYKGMFLSVQDSSNKVHDYSRKTFETIQQLIYFLYFDKFEKKEIPKEIKEEFKDLKDYYQLNENSIIDLLLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVR9</accession>
    <name>A0A9Q0LVR9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVR9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="279"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="453" mass="54093" checksum="56E7F5B4444BA73F" modified="2023-09-13" version="1">MESILSYIYYGNISFENQENFIELLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNQRLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIENKEKEIEEKWKKEVEDKNKEIENKEKENQQMKIEIEEKWKKEVEDKNKEIENKEKEIENKEKEVEKMKQEMELQKIFADSEIVQDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLIIIKTKDNFIFGGFTQVGFNGNTGKINDSSAFIFSLRNDKGDRIPAKFTYKQNSAIYSNLSYGPLFGGYPYDFCLNSNLQPGYSNFGYSYNLPNGITYGTNEAKSYLAGSYSSWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW87</accession>
    <name>A0A9Q0LW87_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW87"/>
    <dbReference type="OrthoDB" id="10660143at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="95" mass="11426" checksum="7D8CB5AEB010C72D" modified="2023-09-13" version="1">MWGIFVNFSKNKELQIQALVEKLRSEKEKQKKRYQELESHLQRRMSDIDSFQETNKEKSILDENAILKKKFSDLADLLKQQEQLTISIWNKLNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWH1</accession>
    <name>A0A9Q0LWH1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mannose-p-dolichol utilization defect 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWH1"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="139" mass="15555" checksum="8EF8E577113DF371" modified="2023-09-13" version="1">MNATQKFFGLISQECYEILLEQKIMDTNCLKQIISKLLGLGIVVFSVILKQISFNNLCTGKLSLISTLLAFLGTIVRLFTVIQDVKDQLLIISTVTSVVLNGILVLQFFIFSNKSEKTSDPNSQKQNSTNTPKRPRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWZ1</accession>
    <name>A0A9Q0LWZ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWZ1"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF263">
        <property type="entry name" value="PLECKSTRIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="82"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="301"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="748" mass="87988" checksum="97BD8B6F12AE5F14" modified="2023-09-13" version="1">MKNIEHENLIEEIKQINLQNFSTNEIFFEKEKNKLTKNQEEEIFNSYKNKESSLNKLTIIGSLLKIKLAKKIQSKNESKKENQKSAVEEILTTERNYVQKISTLIEVFVKPLNKESLLKHGLINSNQFSSLFSNIQVILSLHQSTLDELEEKIDKNQRNTQVVADVFLHFSNFLKLYLVYCSNYENSIQTLNDLTKKNVKFTNFLVECSKNSKLESLSLSSYLILPVQRIPRYNLLLHEIFKSMEEEDPDRPKIAEALTKIHDVADYVNDKIKEFENLRKLFEIRSSFDSHCPEFLLPHRKLIRFGPLLKISPKVVAQKRYFFLFNDLLIYADKPFHKYKHKFSMKIESAWIQDLPDIFQYSNAFFIVTKTKTLTVFAETPEIKKKWIEDLRNAFEEQSAKNPNQKKAVFSLPKKIKLKFSITLKILGIFENLKPPTEGCYSDQSAFIEGDDFIERKITKLNLNSQNKSSEKKHFRKSVSINLVKSLRKDRKKPNLPNKRSFLRNTTNLSSVRNSENSLINTQENLQYQIQNDSNTNNSLLKQNRRKSQEFPKEQNFYNLSSNHQNFIAQKLLKNRKNSRVEKKQRRKIAKMLEINKAKAKTKPIPPSLESKPKNLDIYYEKNQIDTLIANQNRNSIRNSNSNSNQNQNQNENSNQNQNQNQNHNQNQIENQIQNQNQNQNQIQNQIQIQNQNQNQNQNENENQNQNQNQNQNQNQNQIQNQNQIQDQNQIPITKISSFYSKKVSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXR2</accession>
    <name>A0A9Q0LXR2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intermediate peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXR2"/>
    <dbReference type="OMA" id="YNIEPAL"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="249"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5079235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="701" mass="82933" checksum="124371A391282F69" modified="2023-09-13" version="1">MKNYFNKIQNNLFKFYPSFLIQNFFHSFKNNPKQESNKFSCLEKPHLIMNCLQNSINKTNNLMDKLIKNGTINLKKTIGNEKQKIEEMENILDLFSQISNSISKIADISQFFQFSHPDKEIQIQSRKCFGISKDFIQKLNLNENLYSILKEVKNQEEFKLLSKENQRVTNLLIEDFEESGICLSQQGKLEMEHIQSKIRDLVFEFNKNIDESIPEIEISEESQNDFLEELKNIESENKQNSKNRIISAFLKSKKEDIRKSVFQSILSTPVENVDVLKSLEKERRNFSKKLGYESYSHLALKNSIMETPENVIQFLEKFANEIEPRVCIEMDWLKKEKEKETKNYNSSSEIQINPWDYEYLSESILLKQFPELSNNSSFSLKKCFVGLKNIIRKQYGIILQDCNVSNEKIWDPKVKKIYALDEKTGELVGICYFDFYNRKNKIFHSGIFPISSGIWNRKLNKKRQIPELVVLFNFLEEENDDAHLTFQQVKILLHEFGHLIHYLLSNVEHHHVSGLRNLSELEEVPSILYEYHLFNWEIVRDLLNNEGNEDVKRITEKIKYSFSRFFAISTQKKVLDSLIDLKIHYKTNFPKSVEEIYQKLMIRYKSKSFKYCYPEIRLRHLCFNPSSHYKYLVSSCIASIIWKRIFGEDAFNKEACNKFKNLFLIKGGSLDSKEILETILIQSKWKKEDLIKGFIEMNLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY07</accession>
    <name>A0A9Q0LY07_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ngep-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY07"/>
    <dbReference type="OMA" id="CFFTSAV"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="282"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="744" mass="86886" checksum="03942710E70B96EE" modified="2023-09-13" version="1">MLNPIDFIKKPKKPTFPKEIQTTDWETEFVTEIDTDTNRKLIQKEENEKKIVDETETESDKNDTNSEIILEEKDNQDQDEIIKRKDNQDKKKKHMFYEIAIVMKDPEIEDGKCGKKITPKEINKIQVEQAKILDKIRESGLEIEEQDVDKKPLHFYLVGVSLRMLEKWGEEMRTKVRLIQKDLKQIEHYSEFRIEDKSQYAVSQDFPDCVFPSAARQSLVTTIIQEKRGRGGCNINIPKSLHKNYMSGYFGLHNTKERTDLYASWTKRPSELFQFKQPENKIRDYFGEEISYYFAFLGFYSKWLIFPSVLGLVFTIAKYTNEKFKKSYGYVSLAYCLFNALWVTFFIEFWKRRIMTLAFRWDLLDLNTVDETPRPQFKGKTRKSPITGSIERYYPEWKRKIKYLFTYSIVLIMMAAAAACSIGINWKKLKGEKNLTMGYKIGTGVGTGASIFILDYFYRKIAFYLSSWENHKTEEAFQNAMIIKLFPFQFVNSFSSLFVIAFVSRLPDFLDTQLASLLLTRLAIGNFQELVVPFLKGKFRNCCSTFSRKSEKKMNPIVNQSNLPQYDNTIDDYSEMMLQLGYISLFSVSIPAVSFLAYLNNLIEIKVDSAKLRTMQRPLPRIRIGIGNWSYILNVISVLVVMINTALIAITYSDSLKDLSGFDTTNNRLWWLIGLEHAIFLIKYICHMIIPDTTTEVSDAIKQEQFKREKAALLYGKGIFEEDFNETESENEDFNETNDPEIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZF6</accession>
    <name>A0A9Q0LZF6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZF6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="25657" checksum="C7EDA1769D507B74" modified="2023-09-13" version="1">MFYSLINEKNVSFVIIFNQLVIKFLQKFNQSNNTIPLNSYFPFPSYRSLISLLFADPNIVSLKFIIQEIQNNLNLKQSKRKLLFILLLFYHWIIFAIQKITFSKKQKQENIILLEFLDQFLNLAQSLNNNNNKNIIIHISDLFLKDKFKLNLKFIQNLENPNLSFGLIYFLLISYNQFKHKNQIEKIFPKLKENLIRNQWNLHLFYFSFYSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZG4</accession>
    <name>A0A9Q0LZG4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZG4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="150" mass="18163" checksum="E99DDC3EBEDAA9AB" modified="2023-09-13" version="1">MIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLTNKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R462</accession>
    <name>A0A9Q0R462_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl-peptidase 4-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R462"/>
    <dbReference type="OMA" id="VTHMTPQ"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="600"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="798" mass="93297" checksum="354D6834ED2336D1" modified="2023-09-13" version="1">MTNQLKDKIQQISYLLSQSNHQKIPRNLHFYEDKLLFIGEDYKISRTTNLYTADIKTGEWKAIYEGNLTESKKTLSKEEILLQERQRKRNFSGLSNYIINEKNQILLFPLSGNTIYYDSLIETSKNSFTNKDINKSLIEITPKDSISSSPRMSPSFSSDSRFLSFVRDNDLFITLIDNKNQNTNLFMEFQLTQGSKSAYAEFVMQEEFDRFDGYWWSPSVYLNDSIRTYRILYLEVDESEITKYPILNQAKNSFEVDNFLFPFVGTKNAKCDLRLIEINENIETGEIKWEKYKLKTPIFEEFSWAEYIVRCGWVTDGQHYWVQLLDRSQEKLSLIRFGLDSFISEKNGDQESTKIKYDILIEEKTEIWINVTDICYFFEKNPNQFIWASEKSGFRHLYLKVIVEDEKRNVLEVKTFDITKGENWQVCELVSIDEINQLVYFMGTKDTPLEKHLYVASLKQGNDPTQIHRLTEFGFNNIEVAMNSKCTMFVSKKSSIQKEATITIYGIEFPEGEKYQPPNIKTLANVDTAPSIVYNNIFPICKPEIFNFQSKTGEDLYGCFYRPNEDDFQPPYKTFLNIYGGPHVQQVKNDYSLTSNLLYQTLVSMGYAVVIIDGRGSWNRGLHFESYFKKKMGTFELEDQIQGLKTLSDFGIVDLSRIAVYGWSYGGYMVAMAMARYSNFFKLGICCAPVISWNFYDTGYTERYMDTPQKNQQAYEKETSVLSYVKDFPDETNRFLLVHGLLDENVHFTHSYSLIEALIENGKPYILQLFPRERHGVRNWKSYIHLQGTILSFLEQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4H2</accession>
    <name>A0A9Q0R4H2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4H2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="152" mass="17317" checksum="B7940F188CCBC52E" modified="2023-09-13" version="1">MYLEFYSKSRFINFLLAFCCTIIISCVFLIPSISIAYPDRDIECPKKLWTWIVICNIFFVLNLFFSFLLNILSKNVRKLSFCVSGLFSLFLIIWAIIGLVWAKSDGVKDECGKLYNVTLGDSIALISLIGLACCIFTCLTFCGLLLFRYGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4K0</accession>
    <name>A0A9Q0R4K0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1453"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1261"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1281"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1331"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1377"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1472" mass="173219" checksum="EDF5C3154F3F7AF7" modified="2023-09-13" version="1">MPPIKGNPRKTRPSRRKGRTSKRVYFIRQLIREVSGFAPYERRTIELIKNGREKRALKFCKKRLGTQKRAKKKREELQNYNSMIRKYIQDINESEDIQTKIKFAKLVFQETRNTTEIMDLKGLYLNLFRDTLENQKTPPQFEKNFIYKFRRINLKIMESFTTHLYQKLKKLNKKIDDKQIAQILNFLFSICFQVINQDNEKNSILSFKIMKIIFRFTQINPSKHKEFLNLYKTIIKSLSDKKTLSVLINQQNDNELTRKGTQSFVIFNEMSMFLFSSTSSLISEKNPKNEMSNPLFKILLLQVPESSILTNPHFYFQFVNSRSIIFSLLFKESPENKRTLKPIIKQAFLFLRNSPTESVLERKFVALFLQKWFSLDPDSIHLYIQDLIDTYYLLNKSYVFHQLFGIRINRSLLNLIQISLNRISNISFTKILNWIADNFNTTNFSIDSSQIFLFKIYDLFDKFFLTITSENVQNSLESLFKIFYSLWNKFTNLIFMTKKLFSLNPPQANIYKDSQNSNYHQQINFEETQKKSFLIIKNLVQQLLQTLKSLLSLMRRIMKTFPENIKFISDKPDYSSWFISNYIEENHNNTINNDSNNNNNNDSNNDSNNNKMEIETSENIPSKNNHKIQIHNNITSNPIIESTFKINNFHSALQGIFPFFILDGHLELTKTGFLLMNKIFKKSLKFLIHFFEVETHFKPTSYSNSDWISSENIIEFISSFFLEFGKKSFYILFKNNLQFIAENAEKHPSLIKLVKIFLDFPNFHVFLIEIILSFVLDSVTQTKNQSENLKYSCFLFEQILKPNSIQSHQQQLQLQLQQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNHFSQNQNQLTFFQNLLTNLIPQIIHQSINILKKNKESIPHINLLRITFMASNISPILNSSIFSKLSTILELFHSSFLTLSSQTQKAIIQFIVNIPLNLPFLPEYIQFYIFYLIHALNSKEQDFVLKALVRIEKIIDNLSPQYFFQKIGLPNIQKKFILSITKHLRSENSEFLVQVSSIIGKLAGTGRQFIYNSREEFPNIKGKNYNLKNFKVSFQISHSNSLNFTSNSFQNISFDISQCIDITLNILSSNSKSQNKKYSFKFLGNLLFGWIQNIFHKISSLKEIHQKLILISKKKINKTPKSESKTLSQKSKEIKIKTIIKPKIIKTTKPKPKPKPKSKPILKSKSKSKSKSKPKSKSISKSKSKSKSKSKSKPKPKSKSKSKQKSKSKSRLRSGLRSNTKTRSISKQKFKSKQSKKKRKKEESETDEETDEETDEEIDEEIDEEIDEEIDEETDEEIDEEINENEEIDKTTENETDGETENEETENEETENETNGESDKENEETDKETENETDEEIENQNENQNQNENENQNENQNENQNENQNENQNQNDPKQIFNIFNEETITQLNYSKYLKTSKKTKKIINKIITILLYSSQQFQKEKENQNQKSKSKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4R3</accession>
    <name>A0A9Q0R4R3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_13109</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000131">
        <property type="protein sequence ID" value="KAJ5067239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4R3"/>
    <dbReference type="OMA" id="MALHYAH"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5067239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="557" mass="63211" checksum="CF4FF50CBA89BC23" modified="2023-09-13" version="1">MADPETLFHKQERIGKGSFGEVFKGYDKQTNQVVAIKIINLEEAQDEFITIQKEMSILKQCKSPFITRFYGSYLKGSNLWIIMEYLAGGSVSDLLKPGPLEEVYIVVIVRQILKGLVYLHSQLQIHRDIKASNVLLSLNGDVKLADFGVAGQIGGTGQKRKTFVGTPYWMAPEVIKQTGYDEKADIWSLGITVIEMGEGQPPLSNLHPMKAIMEIPQREPPRLVGPFSKNLKNFVSLCLEKNPEQRSSAKELLKHKVFRNCKKNNILTELIERYQQWKVTHKESESNSKSELDSTSESSDDAWNFDDKKTETTPQNTPKKEIGITKSPIQPRKIIQANSKTSSSYSSESSRSTSNSETDSNSETDSNSETDTNSKTDPQPFNKSQEIIIENSNQNQIQTNSPKSQRINQDSVRKQVPFQNIEQNIKEKQIVTKTNQIKEIPKQNLESESYKLLLDKISQIHKKESTEKSKNAISIVMKSLAYCEESLPGFSDQLLKSLTLNVSESPKNLVRQRSNSPQNQTKQEIKKEVKSKEIDLQPQRSPIGNYLLTRWKKKINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4V6</accession>
    <name>A0A9Q0R4V6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Casein kinase 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4V6"/>
    <dbReference type="OMA" id="FEWERAS"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="116" mass="13124" checksum="5B544A6F486980E5" modified="2023-09-13" version="1">MKYILEKKIGAGAFGLIYQGKDKNTNEKVAIKIENNKTKYPQLFHENRIYRILSGGVGIPKIKWFGSEGDHNILVMDLLGPSLESLFHQCSRKFSLKTVLLIGDQLPQILVLPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5A8</accession>
    <name>A0A9Q0R5A8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beach domain-containing protein lvsc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurobeachin alpha-solenoid region" evidence="3">
        <location>
            <begin position="87"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4704" evidence="2">
        <location>
            <begin position="684"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1629"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1748"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1756"/>
            <end position="1791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1791" mass="212018" checksum="86D97AB877BC2A64" modified="2023-09-13" version="1">MDNLRNLALEAYRLFLHYVNQEQSFNNIFSIQTVFFLLSHKETADFSFVLLDGLLISIKTVNFEEYRLIFDSINKYIADSELKIRTHADSANFHKEQIEKLIALMTKTIDDNPNHLQVLFASSGIFKTLAKILKNSHFEISLIKKILFFLFVIFRKNKKASVLFRREITFQEFGNILFKYEEESPTMEIFILLLNMLVNDGFFDLEKNYIIHNSAIIDLIFSVFARPHLPLFANLIDLFCLLCEKSINNCSCCSEIGLLSTLINLISQLNQKQQLQQKVFYLFKLIAIYRITPKELNQLFSLMKTSTNEFNLPYSKLVFQIIRHISSKNLNDPRIFFDFTNQESYLDIPKTITFPAKNGYSFSMKKINFSMSILKQNQKKNFQNKRKKKNIIDGNILVQSSSEIINHSDSLMKDLNLWKIVTIQNENQNENQNENQNQNQNQNQNQIQNQNQIQNQIQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQIQNQIQNEKEIQNEIKNEKEIKICISLFFEKNQNEKYKANMKLKLHRYQWHCIAMTYTPSRWNSLNDIKFYLDGSLIGQKPLKYPNFSKLTHNRIGSNYQKDTFFGQLGCVYFFKTGLNNQQVNDIYKLGSNPLTFHPLETNIPKSISSLNMQVFMCYNPRVSDTKICFDQSPNNLHANLFEVSRHSSNHIYNTIYCIGGIKIFYPLLTSFHQQKKLEENEQSDNVQDLSQISEYIFDFIADILTRSRTNQKSIIRSSGFVMLSFLLQNIDTQYIGVNIVHSLRKLLSSIQSKVLRRNLYQYLILDYRLWIYCDIPVQKSLLELIEFYLELILENSPDSKTKKKTETYSDIQDLFDIIHFYLWIKPHKFAQAIPNVKRKLGQDTIIGKKPEIDQIMEIRGLYIQLIQKKLLESFDSKIFDFLLSNCFRSEDDDFILMILQMIHFVISKNDIAAIITEESKFFNILEPFIEILKINNQQIRETCLTIILEIFKREITALAEVRQRMDFHGALQVITTSGWNLTPDFWWIIREKEYQDLHQILVQIPLTKQYSEILFNLLFLQITPQKEVKNLIQSEKIHILRTFFSLIGKNKCEESIKVIVEISNSLKKIESNRKNLLSCPNWQEWMFKSFHFTDLHNEIVARNEKKNTKQNDPIASKINHHLCDLLSFLIVDFFLQNKNAHLEIPKTMKIIESLKAKDKIIDDTLITRYIFEKILFSLSTFIHKMSSKFTSELDFNRIKYTSNFQKLLQQPNFTSLMINIEEFLLIIGNFIFFPQMCLLSTKENHFNSNNNEIPQDETNSDENFHVEKNGTKTDEYSTYSIIRFQMENHVWEDYGLVRQLIDFLDFFGFIENGLNFQTKNMKEQLSEKEFETSKRRRKKSFEIFLELLLIGIEISSLNECTQLTQILRIISFGLFSNENQKHAIDILYVVLCSLLNVINYPLKENGNGNEITKKDLLIKDLWSLVQGYDILSNTIQDENGNYFLLNLDTQSTFSKNFFENDQWKFSMENQLKPKLVKFRQKFEKRKAKFCKQSQEININPQNLIQDFTGNIPFKKKYRKMKIEAEYRINESLQRNSINSMKKKWKYSFLSVTSERGTWGKGIQKNELVYWMIDRTEDRARRRRRLKRNYDFNSHQNIRKKEEKLKIESNTNQNQNQNQIENNENNENNENNENNENQNENNENNENNENNENNENQNENNENQNENLNENLNENLNENENQIENENNQNMNIINNYIDNNKKIGVEKPQIIGTEKIKEKLKKQSKKQSKKQSKKKSKKKSKKKSKKKTTLKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6A4</accession>
    <name>A0A9Q0R6A4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar protein sorting 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_02762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6A4"/>
    <dbReference type="OMA" id="QKQAVML"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="657"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="949" mass="111642" checksum="3248635CDCB7C602" modified="2023-09-13" version="1">MFLRFDLFNEYVESQNIISIINDPTKQTWSDWFLDKVFEVPVYTSEEQNISQEFRQKLNNRIKKYYQSIKEIQEKFEENQKLKIQILSRIEDKKLDSTKIYSENQNQNQIKSKSNQNQNQNQNQNHSNQENDLNMNLETMKKIIPSIFFSPFFDLSNTEIFQNIYEIDSDSKVSLKPHQKAQHFLELIENKLSSELLEKTPYIFSSINELSDLTYKVQNTLQKITFIRDLLNKIDQDIVIKSIQITKSKTQQQNMNKLTDKMKLISVVKNGVNTAQLLLNNRDFAGALEVITTTKFVIENQLNGIQCIKGLKMELNKMNDKMKSELCEDFSKFCLNQNENQKEINDTYENLKPIILCLLNIKYLQDAFIQYNEKISNKFENEINKMIDDFLVSQNKQKENSNLPNNLIRQYSSKITTGRKEALKELDSQTFLEFIEKVYSRVIYLLKISLEVNNILKRIFQEILEMKNQNGNEKMKMKTWNGLENNVDEIVINQMIKDSESIINHACEISHNKCTRILQTRKESISIRLINSPQEMNNSIDEFLNLVSITQNFMIESEKTTKYKCNSLDIEIKNLTKKFIEILHKFSMEYIEKILVQDKWKIEKVPWKIQILFNNLDNKKVNLTDENSTKEPKSKDNKEILNNYLLVQGSKFNRIPAVKSVLFLFQILTNYMKCARKFSKSNLTDLMQKIIGILKQFNSRMCQLVLGAGAIQVAGLKRITTQNLALSSQTLNILFETNIKIQKVFSSLLPESYSPLLSEFDKLNRDYNEHKNEVFEKIIGIIQDVLLKQIESFNEIFFPLSQTTKNQINQSQLQKKKNLSKIFKANQTNDDQILIEKLSEDTKRLYSVLKQYIQKIELQEISLKIANIFVNEFINCFEKIEISVYPKSKKKRILEEISSSISILVFLEEILSKKEIENEEFSKDQLNFQNQFAKLRNYFEKFSNSINKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6U4</accession>
    <name>A0A9Q0R6U4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6U4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="440" mass="50721" checksum="A630D09FE90B0109" modified="2023-09-13" version="1">MNDCLFFGLNEKPILIKNERERITKPIQFKFENENEKQIKQISSSSDYSIIFLFENGKVMEYLNDSKQNPQKIQIEIENIQKVTVGFANVTILTIEGNVFAKARYINPNNPKEFINISSLIEDINDRIIEDIVSGWGSIYLLTSNQNAYGIGDNYDSQLGFDYKTLDKTEKPILMMKNVSKIFSGNCSTYVFLLNSNQELFVCGGNFSGRLGLGESRKEQKIEKLTKIQNIPKGKIIDIQCGNFHSIMLIENENQDENPKRKLYSCGDYHWNGLGKNENTYEFTEIKSSLFENDDDILEISVAYKHTLILTSKGKLIGFGLNDCGQLGTGNTEYQSIPIQIELPKLRFNENISNYHVLCGAFYRSFLYYSPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILNYRLKDQNQIEIEKLQEIISNKSIQRIKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6V9</accession>
    <name>A0A9Q0R6V9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6V9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="97" mass="11417" checksum="9F14D7015EADCDCB" modified="2023-09-13" version="1">MCLENLAFNISLFANIAFKRFPKDVHPVSGFSFLDFMSSITISPDHNIIMREFYLKKHLHTQNRDLKTKQSKSVMNNPRRSHGELSISKHKTWREII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R792</accession>
    <name>A0A9Q0R792_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R792"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="190"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="512" mass="60435" checksum="0EE4B4C9EE0413C2" modified="2023-09-13" version="1">MDNLKQKEKGKERSVSTQQKTNKKKYQNNRRNTTEPQKQIIENDYDTSLKFNDENNQIINQGNDNEKKNISPLYKFSVVKINSYGKKQRRTLALSNEGCRNLKGKKEQWFYPRKYIFDFKKNKKKSNLITLTTLHRFKFECDEESQVDRIAEAFKSLKLGKLKGEIVHSMKSPSLYSLSSIANKVDYQSFDFVRFISQHGFRNLIEVKKKDNGKRYLMEVLDKSEIYKKNEIQNITKEREILAKLNHQFITNLQFSFQTKAKLYLVYDYIPQNHLLKQPQENEKIIPLDEQTALFFIAEILLAIEYLHDNQIAYLNLKPKNILLDSEGHIKLIGFEFSKFIKKTTEKNNQENIQKEDLIDLWSIGVFFYYLLVGIYPFPSLVDSEKPLEIILENQIIIPQNLSQNAQNFISMFFQKETLSQLSIIKIQTHSIFDNIHFDIISQKEQESPIIPNNLSTINQNNQENSFYFEEKQDQIITDFDIARYTFSRNENNLNPDESNNNNNNNNNNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7R8</accession>
    <name>A0A9Q0R7R8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7R8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="117" mass="14488" checksum="B989D7AB1AAFAC2D" modified="2023-09-13" version="1">MKSKRIHRNQNQNQNQNQNQNQNQNQNQNQIQIQNQNQNQIQIQNLNQNQNQNQNKNQNQNQNQNQNQNQNQNQIQNQNQIEKFYQMKNKDFNELIKKEYFLNMKQNSFLQRKENNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9B4</accession>
    <name>A0A9Q0R9B4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9B4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="323"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="499" mass="59910" checksum="38B94DCFBDC560B9" modified="2023-09-13" version="1">MDNNNNNNQIENANQNQNENEMKNLEKKKWNQFLSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNQRLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKENQQVKIEIEEKWKKEIEDKNKEIENKEKENQQMKIEIENKEKEIEEKWKKEVEDKNKEIENKEKENQQMKIEIEEKWKKEVEKMKQEMELQKIFSDSEIIQDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLIIIKTKQNFIFGGFTQVGFKYVQSGYEDINDSNAFIFSLRNDKGDRIPEKFTYKQDRAICSNLSYGPVFGRGADFYLGSNLQGGGSNFGYSYNPPNGITYESNEAQSYLAGSYTSWVVDELESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9K6</accession>
    <name>A0A9Q0R9K6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2 calcium-dependent membrane targeting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5071996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="SEYLIMR"/>
    <dbReference type="OrthoDB" id="10260859at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1258"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="146"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="308"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="458"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="902"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1058"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1282" mass="147304" checksum="FCCF448786AB9B25" modified="2023-09-13" version="1">MSLKIDPKYIDGRGRADFQIQVHLIECRDLKGRGSSAMSDPVCFVTVDKKTQKTHVFKNTLSCTFDHLMFFQSKWKPSEFDHKKVLIQVFDSNTIRRNVLIGQYELDPSFVHGEPNHEIWHRWYLGPGDQPPTHENDGIDDEEVEDTQDLQKLILRPPQLDVTGYHLKVYCYRAEDLPKMDTFGKADPFIQVRFAGNPLIRTEVKKKTLTPIWNEMLRLPVYTPTLANMIEIELYDWERATKDNDLISSTYFRFTDVQLEAVNARWVNFYGPPKGNIRTLFKKGHTEETEYKGRALIALEAELATEPSLNKDPTEAPRDPPKQQYILRLDLFEGSEFDTNALEKCFVEITIGKHVARSKTMSTKKGAISWYEQLKDLVVEFPVDVEQVPDIFLNVYFKNKLLGKARVGYVRYKFSEALSGGKEPLWSMLEGDPKSPVYKQDSVAGFLLHRLEVGPAAQLSRIPRQKLAKPPMRRYELRAHIYQGRDLPPADKTGFSDPYCVVRFGSASKKTARKEETLYPTWYETVTLVADMPEPLTLAPDVVVMCYDWDQVTSDDFLGRFSVTTHEIGKRFPSAPRWYKLWVDDPNVVYGEVLASFQLIPLEEAGLFPKPPLQPELKPCLLQISAVGLRSLLPFRMSKIKQPLAEFDCSQGTVKTNKERKKFIFSTDAVSKPSGANPNYLKVFRIPVQIPLNHIFASSVMIRVFDKRSLGKTLVATGAISLAQFIPWANVPLENVNLPPIVDTIPGATVDGIVVDEDDLKDPDKALDAVVVQRDLVPSNIEETNELILSPIIFDNEADDDGIHGLRTIPEVRDQFPDEFIEEKEEEFDDSYQDPKKGRERSTYELEHTFKNIPFLEYELTRGKVRGLSFFEKMFRDKSRNPNAKRVVGKFKGNFKIYEETDTSKIETAPDLLEMFRPQRMVVRAYILRGMSLVPKDSNGSSDPYIVISTGKSKEMTIKDRKNYKKRTLRPEFFKCYELPCVIPGNSDLTISVFDRDTVSSDELIGTTVVDLENRFFADEWKALNPKPVEYRTLWAPTSTNPQGKLEMWIEIMTEEEARNTPQTPLEPPKQENFEIRAVAWNTKDVVFKDKNMSDIFVTCQLNEGKRQRSDIHWRSTDGKGSFNWRFVFPVVLPNRVPRIKFQLWDEDILNPNDSIGESLINLKAFFRKAYKLKSKQSIKRQWIDLLHPNFDGKQGSLELQIDIVTEAEALATPVGKGRKDPNRDPFLDKPDRPFSSFAPWRLDKYFKIGWKKYRGKVLCCLCSCVICCIVILIIVLKVTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB30</accession>
    <name>A0A9Q0RB30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional polynucleotide phosphatase/kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB30"/>
    <dbReference type="OMA" id="AADWKWW"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="445" mass="51714" checksum="21676C197BA58E64" modified="2023-09-13" version="1">MPPKSPKSTQKKRQQDTETTTKNPEEEKDEVKRLKKNKDKREKDDESKIQSKKKSPKKKPKSTPKKTKKPSKFHWKTEKGFLFMNHEENKGVKKIAGFSLDGTVIKTKSSKSIPINSKDWVFLNDQVAPKLKEFYDNGFKIVFFANQLNISKKKLNQTSYRTRIENVGKKLDFPVQAFIATENNHIRKPSIYMWKRFVEEANDNQEISLQDSFFVGNLAGREDDQDCSDRQFAANIGLPFKTPEEIFTNKDVKEEKFSWKSFDAKEIKQNPPKNLYEPSEAKLVSEEQEIILLIGLPVSGKTTFFKKYLEPSGYIGIHREDFTTKTKFLENIKKNVENKRKICIDTTNHTTQSRADILLIGKTFSIPVRAFRFMASRPIAEHLNWVRVIFSNGEISHVPPISFNRCKIDEPLEKEGFSQILKINFVPDLPNEKQSEIFYTWTSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBA0</accession>
    <name>A0A9Q0RBA0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin ligase protein phf9 fanconi anemia group l protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBA0"/>
    <dbReference type="OMA" id="NRPFHAK"/>
    <dbReference type="OrthoDB" id="10263265at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043240">
        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23832">
        <property type="entry name" value="DRWD-C_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23831">
        <property type="entry name" value="DRWD-N_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23786">
        <property type="entry name" value="ELF_FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.20">
        <property type="entry name" value="RWD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026848">
        <property type="entry name" value="Fancl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026850">
        <property type="entry name" value="FANCL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043898">
        <property type="entry name" value="FANCL_d2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044037">
        <property type="entry name" value="FANCL_d3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043003">
        <property type="entry name" value="FANCL_d3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019162">
        <property type="entry name" value="FancL_WD-rpt_cont_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE FANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13206">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN PHF9 FANCONI ANEMIA GROUP L PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11793">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09765">
        <property type="entry name" value="FANCL_d1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18890">
        <property type="entry name" value="FANCL_d2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18891">
        <property type="entry name" value="FANCL_d3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fanconi anemia complex subunit FancL WD-repeat containing" evidence="1">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL UBC-like" evidence="3">
        <location>
            <begin position="112"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL UBC-like" evidence="4">
        <location>
            <begin position="221"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="FANCL C-terminal" evidence="2">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="399" mass="46712" checksum="5763710075387DC7" modified="2023-09-13" version="1">MNNFSNLKLFPLLIPEDQTLTKFSGFIQIYNKSFNFRISMKNPQKISTAKIQCNKELENLLIDSKEIISKRLKESENLNSFLLEFSQIIQQKIEPVLRNEINTSFQPKNPIYFQFLFDEINEIGWEKIQLIDENLSKIQINLKDSKNRTIPIFAQIPPEFPFAKPIIEAPFPVSFENDEEMEEENQQNTRNEKITKNQNYKGSFQKVINKITREFDKYQDLWDNLDDFDSNTCVIEPENPTLLEPSRKILFGKHCSIQIVFNIKFPRSVPSIKFFGSDPIILPLKELLKKDINKWDPKNLVRKNLEEILKIEFPKKTSSSLNDFGPECGICFGYQNDGKSPDIFCSNIQCARPFHNSCLYLYLKFQSSDEFGTIYGKCPYCSHEIQTTKPIDFQEKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBL2</accession>
    <name>A0A9Q0RBL2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-10-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBL2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="375" mass="43080" checksum="CCC5B293D97CED40" modified="2023-09-13" version="1">MKKHLKKIIIDIDARRTKAGFGGEEKPKTIFPTIIGRSKITDNMDIDEKVDVYIGNEAQTKKELLTITSPIKSRSEINWDDIEKILHHVFFNELKVDPEEYPVFLVENPLNPKMVREKNCEVMFESFRVPGYLSESRTVLSLFQSKKTTGIAVEIGELNCFFDSIYQGYSLPYSSLWFDFGGNHLSDYLLKMLKDQGYSFLSSDEKEISQDIKENLCYVAYDFDEEMEFSNQKTLSESNYELPDGKVIEIGNEKFRCAESLFKPSLIGREEIGIHEMINKVINRAFQEQRDDLFANIVVSGESSMFPGIGERIQKEISKLAPNKVINVIASPQRQYSGWLGGSILSTLPNSENSWILKDEYEENGPSFIHRKRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCS9</accession>
    <name>A0A9Q0RCS9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCS9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="259"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="70339" checksum="EFD89CE956C73188" modified="2023-09-13" version="1">MNEIIFFGLNEYPKLFKNEPDRIKKPIQFKFENENENEKQIKQISSSNYSTIFLFENGKAIEYLRDSKQNPQKIQIEENIQKVTFGDENEAILTIEENVFAKGYDINPKKPNKFINISSLIEDTNDRVIEDIVSGAYSIYLLTSNQNVYGIGANYYGQLGFDSETLFNTEKPILMMKNVSKIFSGNASKFVFLLNSNQELFGCGDNNSGQIGLGESRKDEKIQKLTKIQNIPKGKIIDIKCADSHSIMLIENENENPNRKLYSCGNYQYNGLGKNKNTYEFTEIKTSLFENDDNILDFSVGSFHNLILTSNSKLIGFGNNSFGQLGTETGAGDTEDQLISIQIELPKLRFNENISNYHISCGEFKSFLYYSPFSFSNLEEDLIKLFERKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQVFEMIYSNNSKINPILYSEIKEIINSNEKIEETMKRIYLNENENEKEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQLFEYWIYSNQIKEEIQITQEIINEIKIGIDYFQLNQTNPNLFDLLINKFNNQNQKQKSKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCU1</accession>
    <name>A0A9Q0RCU1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serum response factor-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCU1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="650" mass="77387" checksum="5AF04C3B58EE0B5D" modified="2023-09-13" version="1">MNNQENPEEKNQKENPNQNEQEKKKIENKNIKKIQENDNILTNKEENTENQTKTTSTTTTTRRLIRLTPQRKYLSDRFHISQQNSPDSKRTQSQDFIQNLISESEMRSKNNEPKLNIKTSILNYKNLISDVSVIPLSDLLKIIYFSIEETEKNGENTGYQFVLQCADEALNKMKRLKNPNPNPNPNQNPNPNQNPNQNQNQNQNHKSKLKMDQNLISSLNYISAICFYRLNEFEKANAKINDYLSMNKKCRNGFLLQCLISMKRKDYKKAKNALRKAQKSHQTNEFPNYFAIVSAHLYFYTQESSKAESELDKIFLENVEKMSFDLIKSSTENNQKDFLNFIKMKMYNHNWDQVEKILEKYKKNNKNAEILSYLGICYFKKQYTSKKVVQVFQMVKKIQQNQENQENQENQENQENQEKEQNQNQNQNQNQQNQNLNQNLNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNLNQNQNLNQNQNLNQIDNSNIKENWYFVMQYYWAKAFLDEITIEFSHLLNRQLQNKKKRLSPRKSRQNTPNSKIQKKVLPKIKNAISHLDEAIKNNNNIQHTKFYYTRAYAYYLYLEFTKDGNYRDLGLKDLKSASKLTSKQEKIKQLSDLFNIKPKSKVNFFFFFFFLNPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCY5</accession>
    <name>A0A9Q0RCY5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mediator complex subunit 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_06803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCY5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021640">
        <property type="entry name" value="Mediator_Med28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11594">
        <property type="entry name" value="Med28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="126" mass="15126" checksum="4889B502AF9E7EAB" modified="2023-09-13" version="1">MSLVELSLVENLKNSYQKLFHLIMNTEEETNEKKKHYLATEIQQITDSFFYSAKKLDNQLIKIESGLDIPLEKREESIFSINEEIKYLEERIKKKDQLIEENKNRLEKWKKELSELEKENGTFIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDR8</accession>
    <name>A0A9Q0RDR8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDR8"/>
    <dbReference type="OMA" id="CCFSAIV"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5076452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="375" mass="42043" checksum="9F6764B623E0590F" modified="2023-09-13" version="1">MGDDTAAIVIDNGSGIMKAGYAGDDAPKAVFPSIVGRPRHLGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEYGIVTNWDDMEKIWNHIFYNELKVAPEEHPVLLTEVPFNPKANKEKMTEIMFETFNTPAMYIAISSVLSLYTSGKTTGIVVEIGDGVSHTVPIYEGYASPHAIKRLDLGGRGLTDYLMKILTERGYSFSTVAEREIVKDIKEKLCYVALDFDQEMDNAAESNSIEKNYELPDGEIITIGNERFRCPEVLFQPFFIEMSQPGIHELTYNSIMNYDVFCRKDLYGNIILSGGSTMFPGISDRFQKEINQLAPLNMEVKVIAPPERKYLTWIGGSILASLSTFQNMWISKEEYKESGPSIVHKKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDW8</accession>
    <name>A0A9Q0RDW8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-like family small gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDW8"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002060">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="194" mass="23072" checksum="CB57C33938B15E18" modified="2023-09-13" version="1">METYQVLFTGENGVGKTTLLMTYEQKKFPEEYIPSVFDNFLKQFQIKNQNFQIIFWDKGMDEEFHDKLTPLFFVEKDIIVICFAIDYYYSFENIESFWIPYIEKHGPNSKRILIGTKMDLRNNEKKIKKLKKRNEKLITKEEGIELANKIKAIKYFECSSLNQKGIETIFNEIALICFGKDRKEKEKKKGCILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE66</accession>
    <name>A0A9Q0RE66_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_05888</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HLWKETR"/>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001053">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
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    </evidence>
    <sequence length="5071" mass="593247" checksum="1CD33D1BC4E928F2" modified="2023-09-13" version="1">[encoded data, 5071 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REK6</accession>
    <name>A0A9Q0REK6_ANAIG</name>
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        <submittedName>
            <fullName evidence="4">Fam11a b protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">M0811_00100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
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        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REX2</accession>
    <name>A0A9Q0REX2_ANAIG</name>
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        <submittedName>
            <fullName evidence="2">Tobamovirus multiplication protein 1-like isoform x1</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">M0811_05039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5078251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
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        </location>
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        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5078251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="274" mass="32544" checksum="48CD6509EA412E55" modified="2023-09-13" version="1">MTTDKTKRIISYSILIVLYAFMSVYVLRKVIISYLRNINKKRVDLRVYQVYSWLILFFSFAKIIGSLFIILEIQKNDDYDVFYSIANQFLLAAFFSITISVANIRRSIYPESIQNTKLRRFLIVLVIILNIVLLIVSLVLLLKVIKAYYIFIASLYFLCGFGLFLFTFFLLRTFKKFDLIDYIPGSKKLIFILFLITLLFFLRLIALLVVDFNDKINEKVNHIFDVAYYFIFEQIPVYLGFYFFAILPNKKERILEISLIKKNEKSNEMEMNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF01</accession>
    <name>A0A9Q0RF01_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyadenylate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF01"/>
    <dbReference type="OMA" id="NPKVYVD"/>
    <dbReference type="OrthoDB" id="1879688at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054000">
        <property type="entry name" value="MLKL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22215">
        <property type="entry name" value="MLKL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040220380" evidence="4">
        <location>
            <begin position="17"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="186"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="354"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="494"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="640"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="724"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="808"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="567"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="883"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="434"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="570"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="890"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="951" mass="110585" checksum="31EC28AD573C371A" modified="2023-09-13" version="1">MAQLILLGSLKLVCFVKDLFETYKANEKERIRVLDRLEKLSQVLEKWKTKTDQVEKSWATLGRLESALDKYYAFLVSQVKKKRIRKFLSAKKTRICFEEFEKIIDQCRDDLALELTIDTNEKVTDTSKKVTDTNEKVTDTNKKVTDTQDLINQMNDKLGVLIGTLPQKQIEQDKNIITMNTQKSNPKVYVDNLPLDMTEEEIKTEFSKFAEVINVRILQKSGSPARYAFVEMKNMEEAKKVIDKFNGAKVNGRTIRVELAKPKQLSRQSSRQSSRQSSNQQSNQQFQQKSNQQSQQQSNQQFQQQSNQQFQQQFQQQFQQQFQQQFQQQSNQQSNQTNEQDKNIITMNTQQINPKVYVGNLPLDMTEEEIKTEFSKFAEVINVRILQKSGSPARYAFVEMKNIEEAKKVIDKFNGAKVNGRTIRVELTKPKQLSRQSSRQSSNQQFQQKSNQQSQQQSNQQFQQQSQQQFQQQFNQTNEQDKNIITMNTQKSNPKVYVDNLPLDMTEEEIKTEFSKFAEVVNVRILQKSGSPARYAFVEMKNMEEAKKVIDKFNGAKVNGRTIRVELAKPKQPSRQSSRQSSNQQSNQQFQQKSNQQSNQQFQQQFQQQFQQQSNQTNSEVPQLLPIKRQSRTPKEESKTQIHVKNLSFNMKDEEFAKIFKKFKTKECKIVRTRSGKSKGYGFVEFESNEDQKKSLKLNDKEFKGRKIGVKIAYVSNQRELSKTRIHVSNLPFDMKDKEFEKIFKKFKTKECKIVRSRNGRSKGYGFVEFESNEDQQKALKLNGKEFKGRKIGVKIAYVSNQREFSKTRIHVSNLPFDMKDKEFKKIFKKFKTKECKISKLKNGGSKGYGFVEFESHEDQQKALKLNGKQFGRKQIGVAVAYELPKKNDSNSNSDSNSDSNSDSYSDSYSDSYSDSYSDSYSDSYSDSDSYSDSYSKIKSETESETESETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFJ6</accession>
    <name>A0A9Q0RFJ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFJ6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="208"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="313" mass="37650" checksum="661F5E239775A678" modified="2023-09-13" version="1">MLIENQNQNPKRKLYSSGFFQFNGLGKNKDIYEFTEIKSSLFENDYILDFSKRLKNQRIPIQIELPKLRSNVDISNYHISCGYQKSFLYYSPFLSSFSNLEEDLIKLFRRKEFCDITFKTENGEIIEAHKLILKYRLNQNQNQNQIEKLQEIISNKSIQESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDTSIKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFW0</accession>
    <name>A0A9Q0RFW0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFW0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="382"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="561" mass="67084" checksum="1C2A28C402D34AD8" modified="2023-09-13" version="1">MDNNNNDNQIENENANQNQNEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLKSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIKKRNKRLKGKKEKEKEKEKEIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKENQQMKIEIENKEKEIEEKWKKEVENKEKEIENKEKEIEDKNKEIEEKWKKEVEKMKPIFDKYQDQYQKDLEYEKKMKELQKNFPQFSETRIITEEEYVKKLQEWINDNDFFSKMKKGFSAKRDGFDSQNWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGFKYVQSGYEYINDSNAFIFSLRNDKGDRMPAKFTYKQGHEGCAIESNLSYGPTFGDGNDFKLESNLQPGFSNFGYGYNLPNGIKEGTNEAKSYLAGSYKSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH03</accession>
    <name>A0A9Q0RH03_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH03"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000006">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="348" mass="38800" checksum="1CCCDFC0F9D3B6E3" modified="2023-09-13" version="1">MFRSIEYIPDKKCVKIIDQTKLPHETIFVELTTYKEIAEAIYTMKVRGAPLIGVTAAYGIALASIEFLDEKIEIFTEKLEQAKTEIDKTRPTAVNLFWATQKMMKKFYALKKTDKTVDEISNFLVEKANKMAEKDVSINFMLGKNGASLISNGDCVLTHCNAGSLATVLYGTALSAITYAFREEKKKINVISDETRPRLQGATLTAFELQYQKIPVKVISDNSSGLLMRLGKIQKIFVGADRITSDGVFNKIGTYMVALAANANNVPFYVVAPSSSLSLSETSVNVKIEERDPFEVSNVLGKTRIVPEGVDCLNFAFDFTPFDLVTKIITEHGIFTSKELIEFYSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHX7</accession>
    <name>A0A9Q0RHX7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHX7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39464" checksum="94B7E50574D7064C" modified="2023-09-13" version="1">MGIKHSISTVISSRKKKSFLKLLGFSIESIILVNNSDKILYANSVAENFFCDSTKKSLTHFKFSEISNQNQFQMNKSFQEAQIEIIDKIIKANDQAYDFDWVMKTISGKELLVHIWATLIDFGGEICVQQIIRKTPNFKKAETSQKSETSQEKNSESNLDSNSEKSGIISKNNSFNQIDVSNLSSTDKTSTSSQVTPRINTRNPTFLSVEDQEFEEDLENKIDTTKMKIRSFDDPEIELKIVDALNSIQKLSLEWISSKNLFLQDISDRIQSERQKFRQKYNQLESQLQRRLGGFEAEKEVKNSVVKKNEKLKKQLDSISEIIKEQSPITQKLYQEVKNLETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHZ2</accession>
    <name>A0A9Q0RHZ2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000002">
        <property type="protein sequence ID" value="KAJ5080742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHZ2"/>
    <dbReference type="OrthoDB" id="6134519at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="38"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="317" mass="37342" checksum="77F095A160B80A94" modified="2023-09-13" version="1">MSEIFGFSLQIPQPYSNLTELSLNLKNLLTNEKTETLSDFQIIITNTKTKEKQKITFNCHRAILSCRSQYFQGLFRSKMKEYEEGKVEFNDISPQIMEQMLQFIYTGTIKIDEENAIDLLISAHKLLLFDQDFFDFLGEFITKKISSQNVVEILNMANCFGLNNLYDFSLRFISDHIQDIIQNDSFQFLQENELMNALNMDPIMIDDEMELFYALIKWAQSQSKLNISVEDLEHLNENQNQNQKSNSKIKIKIKIKIKIKTKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L522</accession>
    <name>A0A9Q0L522_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L522"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="126" mass="14905" checksum="B6D01E92697FA8DB" modified="2023-09-13" version="1">MYINQTTETIQPPNSFLFFHQSSLSDQSQPNFMNHPSENFTHSQNSNYHPNQQSFRKTQIHPDNGEFLNENQEHFYAKTHSDPNQFNQFLQTSENSKLINNPTNDRNNIFYNNNNTHHNNNSNDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L538</accession>
    <name>A0A9Q0L538_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_03379</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L538"/>
    <dbReference type="OMA" id="YDGVHVD"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="348"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="544"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="694"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5066046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="745" mass="87085" checksum="74CB424BC7BD1FAC" modified="2023-09-13" version="1">MIFFFPYFIFNREFLVLFQKEKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQKPRYIKNFLLRNLVAFFASFYSYYIPVAPPKEEEKEKDNENDDKNEIEKDKENEKENEKDNENDNEKDNENDNENEKEKDNENDNENENEKDNENDNEKDNENDNENDNEKDNEKDNENEKDNENENENENENENENENDNEIEKDNEKEKENDDENEIENEKDNENDNENKIFFFIFFFIFFLLKMLSQDQIFKKLVYGVDIPDPIESFEKLTGKIPKQVLDNILIDIGYQTPTQIQMQTIPILLKDRDIIGCAPTGTGKTAAFAIPIISNLKFHKKQGCRALIVSPTKELASQTFREFQALSKGINLKIIALTKKILQPKESENVDIIITTPLRLVYYIQNNQINLSSATCLVLDEADKLFEMGFLPQIDKILNACTNSKITRCLFSATMIKPVEDMALTVLRNPIKVVIGIPNIATNLVEQKLIFTGNEEGKILALKQIFQDGIKPPVLIFVQSKERAQQLYQELIYEGMNVDLIHSALSNIQRKIVIDEFRSGKIWILIATDLMARGMNFLSVELVINFDFPQSLISYIHRIGRTGRAGRVGKAITFFTEQDSGLLQRIANVIKKSGSEVPQWIFSLKPPSHQTIKRLESKPRKRDPISGKKPFQKKFKRNFLRNKKRKKKFHKKPKSKSKSNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L619</accession>
    <name>A0A9Q0L619_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Activator of s-phase kinase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L619"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="5">
        <location>
            <begin position="156"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="209" mass="24604" checksum="3ED6A7681A9DCC61" modified="2023-09-13" version="1">MEFKGKIFFLDIHDSTLREKLIWNISLIGGTVVFDELTPKVLFLITDSATHQSEKSSSLIQTAKGLNIKIYAGEQFNQLLENKIIYSKRKTPNIIVVEDSTKIHRPSFREFKEDSIPLSSHFVSATSKPRNPVFSLEFLEQRAKENQALQQKKRRKKKKQKYCEICGEYYSNLHSHIVLKMHRNFAKKKKNYQQIDQLFKNIRKQEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6K7</accession>
    <name>A0A9Q0L6K7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6K7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="803" mass="95073" checksum="33D4CF2C574CF066" modified="2023-09-13" version="1">METNFGSLFRNRKQINFQKFQTHYFSKILENSGFEKHNPKGLEIQNLWKKSIEIKDVQTHNEWFHNFAQLFLQNYQDWKPKENEISNKFDFEQFSQAIQNDEAHPTRLIFETLRNLVFYLLHLKKSQANITNEIYQTKNNDKIEILSLEMLVILSNSRFNRAILFKYGLFDILVELGLVVYAKAFNLAKKLSLKQNLESNSRDVDNTNIDVNVDDDFDIYIYICSSINRILCFFLMNDYQFEKHVPQNIEHGNNDKINVIDREEDEEINLYDISITGKPYLSWISELFITDLLFLFTDLFNEFEQKIKRTEILSQTHISLLNLLLFTFSHGLISKELTTQASNLVISQLRPPSIVYENLNENQNQIKNQNSKYLGFEKRMIILQLLREIIVNIPDSEIAVCKNPKLYYLSDLILWVAYTFPQDWVYETINENEISLDNLNEESFNLSNPKKDYSPPSSLPKPPPLSSIQRSKTNPKINLRDFSKYLSNPFLHRLFINLSEICLHKSQKSTTDHEKKPHESRSNTISDQENQNKLQSPRIARSTSKTIKQSQNKIKYKIIEACLNIWDTRPSKKSELDPKIRLFFTFISPELQFFILELLLKVGAFDIRNILTKKTVWNILFSQAFWHSPQFENVHLSKSHSECFQSKKIFFQKFVYNTASRKDKPNLSECTCLIEMFEKYQDDLQIKHEVLDLLMKILISNPRRTKKSLVSLNFISKISAEIRRFHLIQRKYMKKDIKTSFPFDPKVFHKIRYELFDSFCVLFSIDDIRKQALGDDTTPIMLRDLLLENQTKRLFKSFHIVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7G4</accession>
    <name>A0A9Q0L7G4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000142">
        <property type="protein sequence ID" value="KAJ5066473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7G4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="112" mass="13462" checksum="FE6181CAF51577DE" modified="2023-09-13" version="1">MNYNGFVWWSKNKTEKERGKHSTECLAEKMKKQKQNLLNEFQEEILKQTLNFYKTPSQIYLEVKEKMIKKSEDTNLPISFPSQNSIINQISKERKLHFPYDLIFMLTEPLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7M1</accession>
    <name>A0A9Q0L7M1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Fimbrin/plastin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M0811_03229</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21219">
        <property type="entry name" value="CH_PLS_FIM_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21220">
        <property type="entry name" value="CH_PLS_FIM_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040459975" evidence="17">
        <location>
            <begin position="22"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="18">
        <location>
            <begin position="1275"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="18">
        <location>
            <begin position="1419"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="18">
        <location>
            <begin position="1545"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="18">
        <location>
            <begin position="1664"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1002"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="716"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1002"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5066885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1778" mass="207409" checksum="FCA33DC6E3153976" modified="2023-09-13" version="1">MKIHFLVILFSFFIFSIPCQNENENQNSNKGINNQFTNVQVMREINLGSLFVIVTASLDARNSGKSTSEYYIALPTSTAEHLSMITSFEKDSKEDIKVLLEKDEELSTKDTAIYPYHFQKPIKPEETIHLDIIMYFTNMEYPDPAEVQQTEAPEMIFEDNILFYSPYKTQLQGLSVALPSPTAEYTKLKPTSLQGNKIMYGPYSTEYEPFSVKDLKVHYQRTQPLPYITKLVRHYIISHWSDLEIRDYYYVTNKQAKLTGPFSRLDFVRNPSYFGIGSYQEIVAILPKFAKNIDYRDEIGNISTSTITEEDEITKLTFKTRFPLFGGWKTDFMIKYNVPMEYFLRFDPENDRYVFQAPFGAPFPFPVDNVEVHVVFPEGAKNIEKVLPFKFDEEYEENFIEFLDLAGRTSLVLKKSNLIPQHNIPVQISYQLNFIQNFHKLFLLIIGFFIFFTFLFLLLQFRKSRKKPIKSSLRMRSKSIFKKPPKIELPRVELTQPQTAKTVKKYSRSISMLDVKKVNEKTSSVRQQIKGYLNTGKSHLEEIQGEKIEEVEMSPRQLTMDPKRLYGNLANKVQSPRFSSKQVRFAAENTSNDSNEKNSVDKQSPQSMQMQINQLKAELEEKENELRTVAELGLLVSKENKGLIAEIEDLQNQLLDHEEDDNMRFEWQNMIDELESEKAELVKKNQYLGKQIEEATTTNYSYLDQITIQEEEIESLKKNEKLVSKLKFENIELKNEIDSLQFLKSEIQKFSEEKQELKHQISKLELDKRSLLKSNEEKGDQLDILNVDYNSLKLEMDKLQSQDRKLNQSQSEIKQLKTQLDWMEKFTVSSTKLAETAQNIIELRLSEMENLDQEEKIMNEEAKKTISFLVHKLPLHLKSKNETDVSDENDEFEWMDLDLDDARQESEFIALYQDSKRKLVYLSYLLVFGKLYLDMESQKSLAEKEKNELNEEIQELKRKLEQEIEKNNNLEQILHKKLNESESGMNELQKENERKIQKLNDELNKSKENEKKLQKDLNASEGNNRQLQNQIEELKQSLENQKQLTERQQNLNDSLKKQFEEKQKEMEEGFQKEKEEFENKIKNLLANIQKLEEEKKDLDDLINGKYQLEIDDYKFKIKQLGDKIEELNNLLKTQENKFKKEIEENNEKYEDEIKSLNKKLEQEKNSKEKLEEEKEFLKKQLEDEEKTRKKLEEQKKELETNLQIANARANAEYQEKKSLEEENVKLEKEIKKLRAEIAELKKKLEEALSKEPQVVIKEISIPVQSEPELPEREIDLLEQSMIEYINFMFKYDRDLIHILPMGVKTPDLISASLDGVLLCKLINHAITGTIDERVINMNDPSEEQIMENIVLCLNSAKSIGCNVIGMKPEQIMKGEESTILNLAWEIIKIGLLSNVSFERHPELIQLCVDKETIEDIQKLSPEDILLKWFNYHLKKAGHLRRVTNFNEDIRDSENIAVLLHQLSPKRCPIQGFIEESDFDVRAELIVANAAKLNCKLFVSTRAIVSGQYEQLNLAFIANLFHTRSGLQATQQEISKTALQYDKSGTREERAFRIWINSMGIEPKVNNLYEDLKDGIILLKVLDHIEPGCVSWNRVNLHPPNIYKKLENCNYVIEIGKNLGLHLVNISGNNIHEGNKTLVLGYVWQAMEYHIKSILTKLKVIQSGKITDSVMVKWANEKVSNAGKKTQIRSFRDRSIRNGIFFVDLVYAIKPQVVNYSFVQDGSSDSECMNNALYAISLCRKIGAEIFVIPEDIVEVKPKMLLTVVGELMRVYKEIHEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8G8</accession>
    <name>A0A9Q0L8G8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8G8"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="230" mass="26650" checksum="5146B031A9305CC9" modified="2023-09-13" version="1">MNFNQAQILSKELKIKDSVLELLNKSTKETELFSKSFIGIKTIGKCVDVYDGDTVKVVIPIYNYSLVKQFSCRIYGVDTPELRPKGIGKEDPNSEKYKKLQREREAGLKSKEFVEKLILEKFVKLEIKGFDKYGRLLADILINDPKNKTKEINLAELLISKGLGVYYDGGTKIGFEEKPKRKQIKKRKQNNQIENQKGKQKTNQNQNQNQNQKRNKRKIPKETKENSKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8K6</accession>
    <name>A0A9Q0L8K6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="1865"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="2230"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1474"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2352"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="561"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2618" mass="314176" checksum="85E83303515DE302" modified="2023-09-13" version="1">MNQKNEKEKEKEKEILFILFAQKEKKPKLYILEPEKKEAENVFTYKNVYFFNFISSSKNISYSINNQESKKIQIQIQIQNQNQNQNPKTIIYDLSEKEKKKGARIIDAIINYTIQKEYISDFEYFLQLLDQFQKQKLEIKEKTQLIFKSNPEILARMLFVIGLKYSESSVSKIFNECTQQDFQKANEIIISSHQNTQNQNLFSFLNQFLYNYNSKCIDNSNLEFLPLYIHFNQEFTPSKEIIQNSHIKNIISFYLQSKTKFKLTNQILELIFSNKFSYKNKIWFDFIYSKFFQKSKVYLILNPDFQNKLKITKFPNLLECFRFWMECFLSFKKNEYKWNRHEIIQVATIIPNVINDSILNQPSFKKNNYLQKILNSISIFKSEEFQNYNNNAIQKDQPRAEFIEKFENQIQELCENDSINDFQNLMRIDFIKYLPLSIQLEIWRKKLNSQDQNQNQNQRKKKKKDQNQNQKITWIDIFKENGKLQELWKKSIIWFLNFQKSKPINKYLPINVSKDTQKFHEELKNYQKELYQYFQKLKSPEKATISDFNFYLINENKFNEIFNLFNEIEETKEQNQNEIKKNKKELNSLNHKLSKMKEFFDNFEDEKIIKEFKDWEKIKSGEITLNEFSNFFQNIENRKINSIDLFHQNLFFREQFQEFLQNQNQEIKKLSILKICKKVESNWQKWKNSINMETKLEELNEKFPLNKEQFISELLTKNNFPKIEEIKIQKIKKKILKFFQIRKIINNINSITNFLNIFLERNEINSNQTKEIEQLQNIWKEKKINQINDFEKEMNQKINIDYKLLEFIIELFPSNNNSQQISSSEEILIWLKSKNENEIQNEMKKLKSIDFILYKEFKKSLISLKNIFKPILLSNKFNDLHSLQNEIKKIKFQEKTKEEIDVKLLIKYFPLLDIQQFTYSSTNLLQDISNIFEKGCKLIFYLKEPLFKCIIQTEKSNERNIEDFINMLSVALDKKPKIALGDNQENQSKNRKKEYILIQQYEELFKTIDKIYQNLKRFIPIQYYQKIQEIDKPFKIKQNSKKSKKLDYSEELNQFNNKIEENLKKWKEDEEKLKEIPLKGILTNQQLLLIYQNQNQNQNQNQNQNEIFKSIIRLINGEKRTNKINFMEYINPEFEKIDLIDFSKSFFQKIEEGFSLKFIQDSISKINLSIIEKNINLQKIQFKLKKQIDEKRDGSIRNPKIFIIKITEDSKILNYVTMIYYLYLKYFPLREQILICNSNTKPEDIINFFSIYKYYNEIQENNGSFSLLFSIIHADRLSQKCQNILISETNSIDFVTKIPMIIFEFYQKQEKTFLSSLLQEGELNIDFGDEINKNLKQIIECSPIYRNIYVFYSNFTGEGKSFQIRKFCFDFKGKTNNYKYQIIQLNKGTISEMISKLNQITNQLKEKEKEKETIFIHIEFPNKCSIEISDAIWQLTMWGSIENSNPKSSKSLCWNIQSNIILLFEIPNKQEKYQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQTQNQNQNQNQNQNQNQIQNQNENRNEKMWNSFYPLYQFNLHYLNYNKDSFVFQNYEIDSNQKIIEKEDEKLKKVANLMIKLEDKQILNEPDRIENIKEILEKDDKPNPKRFIELIEKNISIVLNQFNRGNMKNIYTFRLLSQFWNSLKVFINLILEWDFLKVKEKKSKKLTRSILKSWFLSISRFILFPLLSENKNIFDNFYTFLPKLQFKNENENIIPISIKSTNEQKLDHFFSGFGIFIKKYSKNSPLLYNPEKITINLGLVESKFSDTFNSKEEIERIFEFFSTLNPKEIDKELIEEHKKGKSKYVLTFDNVSKMLFLQFRNFVNLPTIISGETGCGKTSLIEYLFETILEQKIKTLNVNNSIKKKDIQNLIEEGEKYFPKPFIILFDELNTAPKSFIPIFKYLFIDKMFNEKKISTNIRLIAAINPYRKRSEMDRKEYERFGLFYQKDDENEENKKIQKSVYRVQKLPDSLQKQILNFNSLQKEQELPYIQKMVKNTFDSIFKKEEDIKRIKEFMENFIEYIQKSHQYIREEENQNQNQNQNQNQNEKKNLASKVSLRDISRTLRIFRWIYESRSRAGIILLKDKIDLKQIDLKQIKEKKEEIGIIIQKAIYLSLFVCYEVREKNQKKRKKYSIKIFGNGKSKDYKEMIENAKTNLIENLDYNFKEKMIAKNTALKENCLLLYISIYTQIPLFIIGKPGTSKSISLEVILKSFKPPFEINELLRKLNLRSLYQSFIQCSQITTNKEIEEVFKLAKQNTENENNLGVVVLDEIALAEWSSEFPLKTLHSKLEESEKELSKRLQKRFNQNENQNQNQNQNQNENQNQNQNQNQNQNQNENQNENENQNQNQNQNQNQNKNQNQNKNKNENEKLEDILKEMKTVSVVSISNWILDPSNMNRGILIYRDSITEIETTAQQILCSENTGMNSKIPELFADSLSRIYKNIIKNQKEKEKDSEWKPYFGLRDFYYFVKMIGYSYITHNISYNNPDLISNALLRNFNSKPEIIQNISQFQNESNSLNLISLTKITTKELISQNIQKRIFENYGLNNPNKISDFSRNMMILIDETLNLPIIFTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8W7</accession>
    <name>A0A9Q0L8W7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rcc1 and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8W7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="176"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="239"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="368"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="460"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="565" mass="65956" checksum="0E340DB599FC5ADE" modified="2023-09-13" version="1">MNEIIFFGENALQFKFENEKQIKQIASGFFSTIFLFKNGKAIEYLTGNPKKIQIEENIQKVTSAFRNEAILTKEGNVFAKGRDINPNNPNEFINISLLIEDTNDRIIQDFVSGRNSFYLLTSNQIVYGIGSNEYCQLGFDSITFKKTEKPILMMKNVSKIFSGNASNHVFILNSNQELFGCGYNNSGQLGLGESRKETKIQKLTKIQNIPKGKIIDIKCGYTHSVMLIENENENENPKRKLYSCGNYKYNGLGKYRSILEFTEIKSSLFENDNNIIEISCGRDHTLILTSNSKLIGFGDNSNSQLGNKKLNPEKIPIQIELPKLRFNDDISNYHISCGFNRSFIYYYPNPFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNKNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINELETGIDYFQLNQTNPNLFDLLIRKFKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L905</accession>
    <name>A0A9Q0L905_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5067999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L905"/>
    <dbReference type="OMA" id="CIMETAQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="389" mass="46165" checksum="F1B603F22D6D4E3F" modified="2023-09-13" version="1">MKNQEISKKNEEKNPMIITRNDDEKNRKIFNNNNNLNNLNNQFSNQMNITNNYSPQKTTQPRNQFYSQIQNQNLNQNPNQNLNQNQFQNQNLNQNQNLNQNQIQNLNQNQFQNQNLNQNQNQNLNQFQNQNLNQNQNQNLNQNQNLNQNQNQNLNQNQFQNQNLNQNQNQNQNQNQNLNQNQFQNQNQNLNQNPNQNPIQNLNQNQIQNLNPIQNQNQNQNQNQNQNLNPSFPYQNFSHFNDPNLFFDPQLNILMKGNQSQEANPLVIPSPNPNFDHNYLSPSFNPTHNTNSYENEFQKNDSFLRKDEFPQQNFMNQNNFPPNPFFSHLNHFPHFFQNLNPNPYQNPYPNPYQNLYPNPNLNPNQNPNLNPNVPKISPKNTPSISLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9Y2</accession>
    <name>A0A9Q0L9Y2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9Y2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="202" mass="23935" checksum="91F210A7BD630792" modified="2023-09-13" version="1">MEIGNKTITFEKKEYTIEEAKKLGREKLIQIAINKIQSSFSKPFETSHYDHIRVESNSKNIRVRFYSNINLILLNTAYVYGVTVNLFESSMSYDIKENPEDFEYDFNKMEQFIPNEKSEKALQFILDSINKSEEVGNIDKKKMNYDQIIDIYEFDDYYSVTNDDPYTRSFYKISKSNGKVYDGRHKHKMVGQDKDPYILIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBS9</accession>
    <name>A0A9Q0LBS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uv excision repair protein rad23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBS9"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="370" mass="43236" checksum="970D460DC3CF7C73" modified="2023-09-13" version="1">MQKILIKTISNQNYPIFINLNETVSSLKEKIEYKIDISRELQKLIWKDQLLEDSKTLSSYGVLNEDEVLLIFKVKKKPVLISDFVKDIFPFSLIEESQQINEIIISIKKYNDLFDGKTYELDLKTIPIRMSFWLERLTPISEKQSPSRHSWLNLSPGESIPGKVVTANMNTFEEGTIEIDEINEKIIFNPKKPLISKFGYRCFLTSSTGIKNSEFESLTDLCPSTFYYDFIWEETPNKNPKSIQINQNDLEIFPEMNPQEKWDQMRFFSIIDDPNINSEESKPLEKSLAKINVANLLEFKRGWKEYKNQIQILKEQFQQIILCDCGAFVRDTVLIPCGHTFCRKCAENCLANTCRKCFTKPEKLNPFHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCM8</accession>
    <name>A0A9Q0LCM8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCM8"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="340"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="399"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="452"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="622"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="735" mass="85876" checksum="37BB30A4E8B3E795" modified="2023-09-13" version="1">MNFITLKKIKNNNKNINKTNEILFFGWNFLPKFLKNEPDYIKKPIKINFEIENQNQNQNQIEKENEKQIEKQIKEISSSYSGTIFLFENGKALECLTETYLFRKIQKIQIENIQKVIIGNKIIAILTIEGNVFAKGYGINSRNPKQFFNILSLIEDTNDRIIEDIGCGLNSIYLLTSNQNVYGIAQVDTETETETDTYTYTYTDTDTDTFTETDNKEISKIKSKEIIKRANLEKYSKNKLKQTDTETDTQTDTQTDTFTDKDKDKDKDKDKDKDKDKDKDKDKDKDKDTDTKTQTDTDTEMDINKQIQLELEKPILMMENVSKIFSGNSSNSIFLLNSNQELFGYGDNYYGQLGLGEFQTYIDKVIQIKNIPKGNIIDIKCGFSFSIMLIENENENPKRKVYSCGYYHYNGLGKNENTSKFTEIKSSLFEKNDNVLDISCGNAHTLILTSKNKLIGFGDNSYGELGLGNKKNQSNPIQIKLPKLRFNENISNYHISCGAFNSFLYYSPSFSNLEEDLIKLFGRKEFCNISFKTKNGEIIEAHKLILKYRLKDQNQNQFEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQILEYWIYSNQIKEEIQITKEIIDEIKIGIDYFQLNQTNLNLFDLLINKFNNQNPKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCQ1</accession>
    <name>A0A9Q0LCQ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCQ1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040517546" evidence="4">
        <location>
            <begin position="23"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="442" mass="51127" checksum="7C1B5E53A8307419" modified="2023-09-13" version="1">MKSNLFFFFFFFLIINISLIQSTKNDQKSISTIIQELETTIGTTRYYSSFDGVWIWNLLDQFSSASNYFGYSVSIYKDVIVIGAPDANKAYIYRYNGSIWNEEQILNGPSFSYFGWSVSVYKDVIVIGTYEANKAFIYRYNGAIWNEEQILSESVSYFGYSVSIYENVIVIGTDEANKAFIYRYNGAIWNQEQILNEPIDYFGYSVSIYEDVIVIGAWGEKKAYIYRYNGAIWNQEQILSESASYFGSSVSIYGNFTVIGARYANQTYIYRYNGSIWNQEQILSQPSVSYFGSSVSIYGNFIVIGTLSEKQVFIYRYNESIWNQEQILSQPSVSYFGYSASIYGNFTVIGTRNANQAFVYEAKLIPQVNILNCSSLFSSFDCYWDKIEIPSTLIYQIDYGYDWIDIDYPILEDGNVYYQQFNSSFYDNITGNEYYSIQIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCQ8</accession>
    <name>A0A9Q0LCQ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Well-rounded isoform b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCQ8"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="696"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="801" mass="96792" checksum="7B1D9C3A17A245F4" modified="2023-09-13" version="1">MEINYFSKIIINNENENENENENETTFTNFDQNFKSTKNFFNSSKFETEKLKEKEDLVQLFNQKILKCILNYEFFSLNDLKKIEMIKILSKLIDFIEEEGSKILREKDYKKAIKIIESNLFNFHSILNQNNSNSNSLDESPQFPNQLDLNWEFLESNYLFLISLIEAINTPQLLSKIISKQFILNILKLFENEDWKEKEYLKIVLHRIYGMNLEIRSFIRNKIKDILLTFLYDKEHYNYQNHPGIYSLLEFLSSIIKGFNQPIKQVHLNFLFQVLIPLFKSEKLEEFFDPLSDCIQIYSQKQQDLIPKMIEKLLFFFPKTNSKKMILFLKQLNNLIESISSSGFEIIQSSLFKVLSNLLKTENYSVCEEVLLFFQNQRVFKFISKNFNIILPIIYSCLIDCSKKNWNQAIKDGFSLFLMKLIEIDSNFFRKVMVLEKFKIQKVQKKDLERKRIWNIISYSNQFKKANEKKDFYSNQFKKANEKKEIYSNQFKKVNEKKYFPNLIKIEQSISINSKKKFQQTKKNLNLKTAKEFSSEIQKKWKEENEIFNKNLNKIKQKMERIQENNQIQENNQFKQNNQFKENNQFKQNNQFKQNNQFKENNQFEQNNQIQENNQIEENNQIKENNQFEQNNQFKENNQFKQNNQFKQNNQFEENNQFKENNQFKENNQIQQNNKFKQNNQIQNTFDLNKFVNDLNLFYKSKINEADNNLSQLLNEFNQMKILFTQKINSIQKENQIKLSNQNKKLIEFQQKFKQKENENFDLKSQIQILENQNQNQNQNQIKNQNQNQNQIKKLENENLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCZ2</accession>
    <name>A0A9Q0LCZ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Import inner membrane translocase subunit tim44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCZ2"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="7">
        <location>
            <begin position="258"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="407" mass="47443" checksum="1196AA23D666893B" modified="2023-09-13" version="1">MNSLISKQKTTQNSSIQYYKQLPIKLATRYVFKTNLIQCRYSSMWKGLDTKIVASIVEDEKIKENLKKFQERTTVKIVRKGIDVTIDLVSTILSVSFYPIKLTTKAAFQITKFPIKGVKYMSNKMEQSNNLLIKIPYQVSAKMGHFLIQNPATHLALGSVYEINEKNKEKQKKACGNLILKKEQPLDFKEGSENNYSLIPYPHRNYSWAKNVIFVFEKSPNPIIKIVRYATLIPVNVISIIYESFNYFWQFISSVQMAECVRQIKEISPNFQIEKFIEDLEHLYLPYIMDIYVSGKIQQVKPFLSEKPFHEMVAKLKVVKDSEEIKKKKLLHLSNVEFMSSENTIEGPILMFSFETDQEIQTLSKKSNQLINQEIQQVSYIITIRFEGKNVLWKIIDIIKQKTTSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD09</accession>
    <name>A0A9Q0LD09_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD09"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="407"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="596" mass="71759" checksum="AA0B06AB186922FA" modified="2023-09-13" version="1">MNNNQNQNQNQNQNEIEMKNLQKKVTKNLIKDYSNLLNGNSFHDFSIFVENESNPFEFKVHKSILFSRSPFFNKFLKEQNDIDKIFLNQFNKKEMESILKYIYYGNISFENQENLFELLEISIYFKLNLLKEFIQKKISNSVNYSNFFQFFFQNRDLKSNEIEIKCFELINQNFSQIQNNENLFNLTEKEIIKFIQFKQEKKEIFQFDFFQFLNNWIKKRNEKLKLRGKKEIEIEIEKKRLFHSFFSLFDKDSIPKQDFDKLKEFDFLPKSFLINLERNIFEIQAKEKETKIKEKEKKIQRRDKRIKSFEIENQKKVKESEDLKSQNQKKDQKIHSKSKEIINLKSENEKKEKEIIKLKSENKKKDKILKKKDEEIQNLRSSFQKEIEKEKQKQKDNALLNFFSVSEIVKDIEYVLKLQEWINDNEFFSKMKKGYSAKIDGFSAQNWHSAVDNKGKTLVIIKTKDNFIFGGFTQIGWTMDQSKWSYKLQNPDRGWIIDPNAFIFSLRNDKGNRKPEKFPIKQGEEHHAFWYNYNEGPDFGNGADIELNSYLQPGRSNFGYSYHLPNGIKYETKKSKSYLAGSYNEWIVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD15</accession>
    <name>A0A9Q0LD15_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-canonical poly(A) RNA polymerase papd5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD15"/>
    <dbReference type="OMA" id="LHEDISM"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="6">
        <location>
            <begin position="376"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="5">
        <location>
            <begin position="567"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="776"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="834" mass="99333" checksum="C7DA99E7465EE685" modified="2023-09-13" version="1">MKNVFKTKNNVQLNLLKNETKKQKKNNLEKQKNQKNQNKFEKELYFPNQNEDFAKKTPFISFNEQPEINKSFESNSNKMDNIIPRVFDYKKSQEETNAKCKDDKCQIEGKIDKKPKINTNANVNVNFTSFLLMNNHKSNVYFYDNSFNYYEKLNKNENEIENEIEIENEIEIENQNQNQNQNQNQNQNQNQNQNQNQNQNENQNQNQNKNQNQNQNNKNQNQNQNQNQNKNQNQNQNEIEIENQNENENQNQNQNQNENQNQNEIEIESKNQIKNQNQNQNQNQNQNQNQNEIEKEEEKEEKEEKEKTEFYEKAFEEMKKLSEEVFRISKNGKEERKEERKEEKKEEKKEEKRDSFKYAIWKKEQKYLHEDISMKLHAEVMDFYEHIKPRGAEIILRNEVLKRVEKFIKEIWNEAEIILYGSSGNGTFLPNSDIDITIILNNDISNDRLIKKLSQEILSSKKEIFAVNQVIETAKIPIIKLFDKQSQMLIDISFNAPSGSKSVQLIRKYIKIYPPLQPLLFVLKRFLQVSRLNEPFHGGIGSYPLILMLVSHFQLHPSAQNQKYTTNLGSLLIDFFNLYSNFNYITTGINVLENGSYFSKQELGFLNPNQPEIPVIIDPLNPTLNASRSSYSIIDCIDSFKLAFDLLSNDKGLKSILIPYKFEKYYNLLSFGIIPFNSFTPNYQKNFNFYHPYSNQSKNSKENFFQIKNYSNSRTNYSNYSNYSNYANYSNYSNNHVSYQKNIVVDSRSFEPNSRKIICNYNQNQNQNQNQYQNQNQNQNQNQNQNQNHKFFPNRNYFGGKFPNLEEEAPRSQRYSNNREQKRHRYKKSNRFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDL2</accession>
    <name>A0A9Q0LDL2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDL2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="263"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="437"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="564" mass="66020" checksum="B0C1C7F8B059338C" modified="2023-09-13" version="1">MNDCLFFAIEYLFQNSNQNPSKIQIENIQKVTVGYDIEAILTIERNVFAKGKYINPKNPNEFINISSLFEDKNDRIIQDIVSGNSSIYLLTSNQNAYGFGANYNGQLGFDPRTLKKKEKPILMMKNVSKIFSGNSSNSVFLLNSNQELFGCGDNGYGQLGLGESRRKETNIYKLTKIQNIPKGKIIDIKCGFVYSIMLIENENENPNPKRKFYSCGDYQYNGLGQNENTYKFTEIKSSLFENDDDIIDFSVGVYHNLILTSKGKLIVFGDNECGELGTGDTINQLIPIQIELPELRFNENISNYHVYCGHFNTFLYYSPFLSSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNEIEKLKEIISKKSIKESNQIFKMIYSNRIINPILYFEIKEIINLNEKIEETIKRIYLNENENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEDIQITKEIIEELETGIDYFQLNQTYPNLFDLLINKFNNQNQNQNQNQNQNQNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDN3</accession>
    <name>A0A9Q0LDN3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDN3"/>
    <dbReference type="OrthoDB" id="297375at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="444" mass="51435" checksum="A8DCB2646C2146B5" modified="2023-09-13" version="1">MNDCLFFGLNRNPELFENEPYKITKPIQFKFENENENENEKQIKQISSEEFSIIFLFKNGKAIEYSNQTNSKQNPEKIQIEENIQKVTVSFVNEAILTIEGNVFAKGKNVNLKNIKEFINISSLIEDTNDRIIQDIVSGLSSIYLLTSNQNAYGIGSNFWCQLGFDSKTLEKTEKPILMMKNVSKIFSGNCSHHFFLLNSNQELFGCGDNRYGQLGLGESTEKEIKIQKLTKIKNIPKGKIIDIQCGDDNSIMLIEDEIENENPKRKLYSCGYWEYNGLGKDENTYEFTEIKSSLFENDDNILDFSCANAHTLILTSKPKLIGFGHNYYGQLGTGDTEYQSIPIQIELPKLRFNENISNYHLCCGYLKSFLYYSSPLFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQKLKNLKKLFQKNQLKNQIKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDW5</accession>
    <name>A0A9Q0LDW5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="64012at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF1">
        <property type="entry name" value="RETICULOCYTE-BINDING PROTEIN HOMOLOG 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1945"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="466"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1954"/>
            <end position="1978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2127" mass="251519" checksum="526FBC60910EAB0D" modified="2023-09-13" version="1">MTLKLDLPLIQGGNNPQIIGVYADRKNIETDWENDFIFEEQENNNSNTIFNLDPNEKLGNIDSKSPQKQGKIENLLTPRKLRTTIFKSISKTDTPKRPDSIAKILRNYLKILSQIPQEQTGFEVFREDIKRSVNSLLDIDSPLTNLSYLEKKKLKPSKSLQINLDKKFFQSDDEKTKQNNNKENNKNNNNNDNELKVKNSFPLNINQPITERKFPPKKILKFKEMNENNIQQQISELKIQYPISDNQDSLLNQAQLNFEIGKIFESNKLKKEALEYYTKAVDGISSYRKYNDNNNIRQKEMEFIFKFAEITQVLGMEKNSKQLFKKCASLAQKEKAEEIQRKSYYNIGRYYEIKKKIQKALYYYAMSFKLILKIICENGFCGNQKKKVQETVIKTAKNFQVENKVEYQDENNLKNQIFAELSLLCLSVGRICSSPFPFLGMRKEVGLNYLKFARNFAKMSRQDRIHSEAQRILNQKKSKMQNIQRKSCLFSVDRMEIDGIQDFMTSHSNLNDQIKKQEIEKELEKSEDEDWDLEITAQEKISQTQRSQTFSKLSEIFKEIMRDDLLKNSSSIFPERWKIIDSNLDHVQVIKYPIPSLLYSSWPNIGVRIFNEAQLENWLTNLIEPFLNSTKIRKKSRKTLKKNQFNMRISEEIALKYLKKISKLISNNLDQQATSLILEFFKLLQSNTISISPQFNQNISMISLAMIRMQLSKNPNQIKKHLAIIEKIMKNFYTNAEFLFNLLMLEYQSHISKDSNIENDITTIKKYIEIYEIDLKEKEFVDFFLLKNFTENEEDFENYLKLTVLIDIQLYLKGFSPLNDTNWLLPKNKANKSWKENKYHNKMERILKNFENPLVINEQHRIEAILKLYSQIQPNYMLDCGILKAKVGFGLSYYYFDSNQLQLSEKFAFESLYILSRLNSTKEEKEGFFLGIACEKAAIWSEYYRIIRPIISDFGFNASVHYGEVLLANDKYRYAILSLENSLKILRLMKQSDEYFRWRCAEISQENQDWHRALMYYIEINDESTRKAKRNEMIFLSEVISGILTENSKFEHARLVIEKTLMAVQNMVQDPKLKMSKYQAQIHSLKLTMAKISLKELVIENAIQILEELDYLHLPIQIQSKAFLFLAKAYIAKGSTSKAFHYLKKFNLNKANEFREEALTQFRYDDLNRKNQLQSKKKEIFERNKKSKSGHFMHFQNQNQDKNRNQNQDQNENENQNIHRNKSFNYDNSQKQNIQKYKNFKEINSKYFNDYSVYLILLINAYIQAEKFADSQFWSQKLIESTQGNNISLLGKYHYLKAKSLFSLVKKIFKFQFPLKFDLSSNLQDRMLFGKILPSSPTTILNFETPGDLINSCLFDFQEAYRYYHAIGDDFHLCKIDNKIAECLLSYIFPNVAFFGEKYSNVAKLPPLSGMNLFEKKNLQKPFQKPRLKRNLKHQNEEIKERLNSNTFQAHTVKIPLEFIENTTTFSMEIASEISSPFLLLNNYLNFAEIYKLEDNLTQAIEFWNEAKSLFYKLFIRNGHFILSNARYSFILKSFNIIKRICLFLLTLETKIIDENIDVFDTFILLEQILHISNQENRAQFEDNGNLQKNIWGEISKIKINRQKYADGLISYETLMKENKSSLLSIIESNSNKNQKKETSLNFAQKQEQKQEQKVYYETICTLLIDDFLIILIPKKGYKRIYCFGGYRMENYAHLLRNESKINANILVQTQISENYQKLVPNSDFWNEFGEDKNDEEIEEEKPYPIFLDKKLLHFLFEYFAFTSIESKSEKLWRNKIVQNLKKFQEQFTSVILGPLIDSKGFGSKFMKNSEYLSINSIVYRKQNEEEKKEENQTLKLISQMSSYIHSLGNQDGLGLPKFVRLICSKWMIPFPWENIFYPIFFTRGFYLNNLAFNPSIDIQTKKLYFPRVLMFKSLSDSKNSQEIISQCKNQFKKFLHQIHHHHNYNSKNENENENQNQNQNQNQNQNQNQNQNQNENQNQNENLQKNKKYDDTQWLSKIETQEFESSKFPKTIYSEIYSKNPKTIHSFIHKGDFPIIFTSILNVFSFPYSFFLDIVSQFPFYLFVLVPEKYLDFVVKKFVKILIKFFSTSKTVKDYKLQPLSLLKLLSSEIISIRDQYKIPIILYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LED5</accession>
    <name>A0A9Q0LED5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LED5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="83" mass="9952" checksum="1DB224369CBA6DD0" modified="2023-09-13" version="1">MVNSIIFDDALNRTTQDEDGYTHEHLFNQWEMKMVQTPTSYSANERYLPFVFFFYFFFLMPALGWKDFPGKIPSIKQNKTKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEN8</accession>
    <name>A0A9Q0LEN8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEN8"/>
    <dbReference type="OMA" id="RHCIDRI"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056158">
        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="5">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="56083" checksum="AA4BE692776D3B69" modified="2023-09-13" version="1">MTNNEMILSSSKEEIIIWEYQTGTNIKKYKSSGSFKCGFTDKQIYSIQSEKTNKITVWNIANNKPLFTSNLAEQATSLTIPDQAKEYCLIGGESGNIYIYHISTGRLLARFKLHIRKITQIKSAKFPNAYIIITTGEEGSICCWSLVEMISLSTSVMQESNSEIQSLIKPLRKWTQHTLPVSDIYISPNGRIYSASLDRTSKIFDIYTGDMLASIIFPSYLNRILVDNNERFLYVASGKGDVCQVSLCDDLQLGNKDITHSKITNSTFIKNSSVGPQSLTFLDSSTKQIFSGHKTSVSAMNCILDGSVLITGDLEGNVKIWDTFTKQCLNTFQKHNSQVNEIFLVNFVQKEINAELNTISQTKANSGNFAPIKPFKKHNQYEQDVKGMIPMFLPNQISCKIDNVIKNQNSQNQIHLIEQSYQELLHLKKLRSEIKESKPQAQNDSQVSENLSNDDIEEMKQKILRLEDENKRWKTLNNTLYQKLLSLEHSSKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEP4</accession>
    <name>A0A9Q0LEP4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-like protein rasb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEP4"/>
    <dbReference type="OMA" id="LFREVIC"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="22390" checksum="56B954620FF6FAB2" modified="2023-09-13" version="1">MEVKLNDLKIGVYGKDGVGKTAMIFQFINKWVYEEYDPTIDDFYKQQMNINNKNYLLDIHDTVEQDEYTAIREISIKQEEGFMIVYSIDSRESFDSISLFREVICKVQNSEKFPLVIVGNKSDLESQRKVSFQELSDLAGIFSVPFFEVSAKNKQNLNEAFFKLVEEVEKSRAQSQDSQSKKDGRKKGICLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LES6</accession>
    <name>A0A9Q0LES6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LES6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040181237" evidence="1">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="189" mass="22041" checksum="ABEE7F030830012D" modified="2023-09-13" version="1">MNKIILITIFLIEISSIFTLKTTPIWPTTFIADFHTIYHTEPIETRTKQYWDGTNEKIRDDIHKTDTLTETLLLLFGEHKACEILNHTTNAVCGCSVDNGTMPHPTFDEWDFVNKTTYLQKSVFLYQIQTQTGHSYMYWWDVNNAPYTIARMWNSAVDIIYDSVQIVEQIDPSVFVPPSICSEKKFQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF85</accession>
    <name>A0A9Q0LF85_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stomatin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF85"/>
    <dbReference type="OMA" id="LNWGFKL"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="31"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="343" mass="38880" checksum="66574C7D5B20964B" modified="2023-09-13" version="1">MAFDTFYVAIIATIGGILVLFLLTCLIMCCKNCLVVSQNERVIVERWGKFHEVLQPGLHVLRPFRDKPRSIIWRVSDSFVDRYQEEQVSIHQSWIKRIDLRESIFNFPLQTIITRDNVQIKVDAMILYQIVDPIRVVYEVVDLSFAVEKFVQTTLRSVIGGMGLDDTLASREEINNLIQQKVSQVCLNWGFKLNQVEILEIIPFRNVQNAMDSQISAERIRRANIISADGIRESSKTKAEGECQKLIALSKGAQQVAILRAKGEADSKILIAEAEGQSLRIISEALSDYGADPTQYILSIKYLEALRKLVNSANNIVAFVPMDISLVGSLREIIDKKKQLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFH4</accession>
    <name>A0A9Q0LFH4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ring-h2 finger protein atl57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_09906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFH4"/>
    <dbReference type="OMA" id="TSCEHIQ"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5071746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="266" mass="31097" checksum="52180040410C4900" modified="2023-09-13" version="1">MSFSFSFQSSNSTNSNGVTQNSILISGDKVYHNGNLVVDLSNLEGFDPNNSQVQVVNGSVYLNGNLIYDSNPRIIPQLNQNETQNETQNQNQNQNQNQNPFQNQFQNPNQFLNPFQNQFQNQNQNQNPNQFLNQFLNQFQNQFQNQPNFQNQFQNSQNFQNQSNEPNYPNPLNYQNFQQNSNIRFGNSQNRNLNTNEIFAQLPTFKYHQSEISQQKNCPICLESFQESEKLRILPCLHFFHKSCIDPWLNNHDTCPICKTKIRENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFP7</accession>
    <name>A0A9Q0LFP7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Androgen-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFP7"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="222" mass="26041" checksum="A9A4910EAAE17B79" modified="2023-09-13" version="1">MFLKVIHNIYIFGVTIACFGAYLWMYLIDYLAKDLLFFFTFWNQAIITLYFTIASYNKIQSFQSKKTISLSTFYSIAFSTSIFTVASFWFLYFQNPQLVVVDDYETRIPMILNHILHSFPIFYLFFELLFFPNYLRKKSLLKFDLISILLISSSYGSLSVLSKFWNLPTYPFVKALPFPYLIITASSGSFAGVIFVLFSRLILNMSSRLFLKMRNISDKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFT2</accession>
    <name>A0A9Q0LFT2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFT2"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="158"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="358"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="647" mass="75145" checksum="A2AAA7797B41D791" modified="2023-09-13" version="1">MYKLKIFLQGKSLKLIEILQTIPNDDLLPCSFLIKYLSKGEKPSFNEFLKFIPDPNVASIWRSLIGYWKHNYKFKNDALVQLSALYSPIFITPAIREISQQNEFIDQEKEKENQEIEKINEYEKAIKVLNKQKEGSVQITTRRRYIQSQQFQQEKLSVNLKKSRLKIPTNSDEKNQSLQIWENFYLVLTLDEIEFYKSKEKIEKIGSLKLKDISVFQKNVLESKLITNTEKDSKFPQEKRAQSLPSTPLRSKKIVSNEKSIQDEQLDFNKIFLIRDSYTGKTIQIKVSFETEKDIWVSEILKRKRALNNNYISIIKQLCYKDPDNIILHNLLVDNRMILASAIIENDSTRIYEKGFETGTSLAQALVYSFYSKNKAHQLIRALIHQEITVEKTTDISLFRSSTFPSKALGVYSHMVGEAYLKETISSLITSVSQIKTYLEVDSDRVGKEAAERNKNAIITISSEFISKIIGSLNQIPVPFFEIASWIDKTIKRIYPLATFRAINSFIFLRFFVPAIATPEAFGIIEKEKVDITTRKNLVLISKIIQNIANQTEITVGNLVCLNSFIAQTSVYVTRLYHELIQIPNRKNIWIQEFKPLSNSQIQESLAYIRSYISRNFEDIRDVLLHYDTTKTLTPFVFDFIENLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFV4</accession>
    <name>A0A9Q0LFV4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Beta-amylase</fullName>
            <ecNumber evidence="3 8">3.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.2" evidence="3 8"/>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFV4"/>
    <dbReference type="OMA" id="TADNMKF"/>
    <dbReference type="OrthoDB" id="1660156at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016161">
        <property type="term" value="F:beta-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001554">
        <property type="entry name" value="Glyco_hydro_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018238">
        <property type="entry name" value="Glyco_hydro_14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31352">
        <property type="entry name" value="BETA-AMYLASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31352:SF1">
        <property type="entry name" value="BETA-AMYLASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01373">
        <property type="entry name" value="Glyco_hydro_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00750">
        <property type="entry name" value="BETAAMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00679">
        <property type="entry name" value="BETA_AMYLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040381373" description="Beta-amylase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5072082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="449" mass="50703" checksum="AEAD329B053A79D3" modified="2023-09-13" version="1">MKTWFFVFFFCFSIYTFGIKSTNVPVYVMLPLDTVNNDGTLNNPTQLATWFQKLKSGNVEGVMTDVWWGIVEKEEKQYNWSAYQQLLTLVKNAGLKLQCVMSFHQCGINVGDQCYILLPPWVLSVGQSNPDIFYTDMHGHRDQEYLSLSIDNRAVLNGRTAINVYQDFMTSFKNTFGSDLGSSIVEVQVGLGPSGEMRYPSYQLQDNLWQFPGIGEFQCYDKYMLSDLQNYANENGHSDWGHAGPNNAGTYNSLPSQTGFFSDNGGDNWSSAYGDFFLTWYTNVLINHGDQILGIAKNIFGSYNMRIAAKISGVHWWYMTDSHAAELTAGYYDTINHDGYNDIASMFKKHGVVFDFTCLEMSDSSQPSYAKCGPQELVQLTLHDSLNHGVPYSGENALTCYDNDSYGRIESVAREGITAFTYLRLSSDLVDNQSNWGNFVNFVNAMHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG34</accession>
    <name>A0A9Q0LG34_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG34"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="616" mass="73267" checksum="67DCE0CA0D6FD48C" modified="2023-09-13" version="1">MQKKNLNSKSNEEFQFYILELKKNFKNLNLQKITELRDKILIIQNEDILSENYKELIEIHRKFIQNGNLDSKLICLDSLQILISKMGIDILNQNYEKLIQFLCRFFLENEIIIIKKKIKEIISLFVVIISPNQVFQAMKNIRNAKDDLFSILMIIFENPNVDFLLIDKKDLISFVLSNISEKNNWINFKTTYLFKTLEFIKMKFGFKNLKEIIDSENKNIDIKEFEKNLELLNEFEKDELDQSEWKNFEANDFKLRRTRDNIRSFRDLSLLRREKPFPNPNQFKNEFKNEFKNEFKNENQFGNENEFKNEFKNENQFKNQFGNENQFGNENQFGNENQFKNQFKNENQFKNEFKNQFENQFGNENLSESEISDDILSISSQINFQEFNSKNQITEKIQKLLLDLENETEKKQIQSCKIIQKISRSKKKEQIPPFSHAILSNLFSLFFKSNSKLIQEIMKTCYVLIRIFGMKILSEIDSITNLVVFGSLREEKKISKISLKCFNILCEKFPSKKILHSLLKLSGHYSLQLKIKSLQFIEKIIPFIIQKEKLLFEDIDLLLELISNLLSSKNEEVEKISQKILTKLFASDIDFILLLEKQPLPLLTKTKIKQLILNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGM3</accession>
    <name>A0A9Q0LGM3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBIQUITIN-60S ribosomal protein L40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGM3"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="109" mass="12359" checksum="5F0B81B4FB23507F" modified="2023-09-13" version="1">MEICVKTLAGTKYLFDIEPNDSIIKLKDEIQDKIGIPPNSQRLFSAGVILEDGNTFSYYGIIDDKIENKIGIPLYSQRLVFPCMRLEDEKTFSYYGIVDGSIIYLVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH24</accession>
    <name>A0A9Q0LH24_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein n-terminal and lysine n-methyltransferase efm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH24"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04692">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF20">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="227"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="389" mass="44969" checksum="07DC5E66DDF4C1A5" modified="2023-09-13" version="1">MSDNLFAEMFEEPQNYYQETKPSTTEYKTKNNQIIKLNLIKKHSLWAHCLWNASIIIAKLFEEEVFSCQNKNVLELGAGAGLPSIVAALLNSRMVVTTDFPEDEIIQNIKKNFEMNISQKKPNNYTDCLRLDGSGIVIVAFSHHRPYLMEKDLKFFDLAKECGFIVEHFSDKNTGPMFPKDPGPVEIRSVVHVYTLKLPEMFDVLDEDTWIPNGQIVPRNIVHQKGFFHGSVHIWILNPKTKKVLIQKRAKRKIVLPDLYDISVAGHISSGDSELETIKKELEEEIGLILTDELSKNLKKIFQYKVKVELNEGKIIDNELANVYLLLMDINDLKSFVLQESEVSEIKLIDWKILFEKLKEKDPSFCPFQQDYLDKLNSEFMKVIENEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHB3</accession>
    <name>A0A9Q0LHB3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein vps13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_10467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="TTDNQER"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="6">
        <location>
            <begin position="3385"/>
            <end position="3452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1410"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2372"/>
            <end position="2394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2691"/>
            <end position="2762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1095"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1421"/>
            <end position="1430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5071195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3510" mass="410945" checksum="C13B834AA8064660" modified="2023-09-13" version="1">MLRNVITSILNKYLGNFFKKLDKHLEIGIFEGSVSLSNLEFQPDALKFLHLPLYIKTGYLQTLQIEIPWEDLANSPVIAIVDNIKIITGPNFLLDHDPELEKERAQKIKLANLEAYEFWKNRKDFKIDDPNNKKDENLTAFIANKLIQNLQIHISDLQFVFEDSISGSNFSLAFNLESISVQSTDSNWNLLSDIANSTESIIYKLLTITNFSIYWDIDFEQENPKEKIVNFKEDEINEQKSKHQYLIEPLNAEIKMKIRQQSFQSQDQDNNNNNNNIPQYDIEISFDNPVLSMGNQHYDTIIKILAALTRFWRAEKYRGYSKPQHRPADNNPQTNAEWWKFIYECAEGDLLKARNIPNWSVFNRKKADRKKYTKIWKQKIRNSLSSKNEKKLEKLEEKLPLNFIIFFRQIAEREIEEEEKQKKELAKLKQIESKNLSNQEKDEQNESLKTKKKSKGLLSWVMRFIVSDDEDSENNDPNQNEDEKISVKFSDEKINELYISLGVTDNKFLSNSMDEGINIRFQINIKNAKIVFSKKIKKDQDYYYSTISDITISNIKSFISIQKNSQIIKLSLNSLEINNHLKQNSPFRRIFYPQKSSQNSENFLEMEIELHPSETASDINIQFTLQPSEIVFVKSFYTEIMQFFEIKDRYSIKEFEDAAVAKFENFAKFTSESLQKAISEHKKVNLSFQMKAPVILIPEKPDSFDSSLLVLDLGSLSFESHSEQNQEKWKRRFSKFSRINFSYQNNENDNLYFQNILSLENLPENDLDDLYDTFHLKLVDANAQLFKNGNNYFTNSNENLNSNSNENSNENSNEKLNKIIQNFSIETTLSISVLHNYPLIPKIRILGNLDRLSLSLSKNQYRSLYRLFRIISKKKSVKTNENTYYEKEKQVSSENFGLQKNIQEVLSDIQFRIKSIEFELSRESHNSVLKKLALLTISNINSQTVVKSFDVSSSFTIQSLDVEDLFAPSENRRYLFRSGDANTQENKFISISFLHIPLKSPEYEKVQTNINAHFNEIHFYFNQSTITELVHFYQSSRSRRRKKLAARLEKQSTMGKKNSNPNLKINANNKESIKKNKKEMQKKKKMQKIYKEKQRKLKAMNKKANPKTKTQNDPKSLDNILKKIQVHVNNLSILLCRNDNPLTELVLKNTQVHIKTLSTESHISGDFSGLQVSNLMQENPQYPTVISLQNSLTFSLSSYDSPDQNGFTSFLDAKVAGIYFVYLHMFTDTLIDFFEETTEMDDLINFGVDEIGEKTRQFLENHPKTSLNFEISDSIGILPRNSRSREIIVGKIDQCKITNTFVQQTMRIQPQKHAQLEDILLQTLHLNFTKMAFMTGLIGRDYQDHLLFISPMDFDLFIEIPKIVLYNSQKFQSYTVLGIIPKIHLIFNQYQYNQFFAVLAENFTEILPQKPPIPSRSDENSTTSLSSQLSSVEVTQDSTINDISEDLVTSTDENFVVFPWLKLRLAFEKCTAEIINGEYLNDPEKQTPDIIGSLVCASASDIGLEILWQTDEKTEIVVQIEDVTADDNNKESQENAFKKLFETMPNHSIELQFYIDEIGNQDIHLSLFGCKLFGLWPTIFSMREFFAPIETEEMFRFAQSKKAIHDEDLRPDYSNLHDFKFTLSASRLFLSLLENPKDALSKCLDLSSDFVLKYRDSANGKVFLEIQMNNIELSSINKFTDNKITILSPTYFFYNLKMNQSQSNRYNWDSKHSIETENLDMIFSFQDLMSLQKIVGDITDSFLRCYDLERYKKVLNRRSTMKISNFEDHQEEWKHIVLEKYDSSEKSELISQIQFFHKEENEDEKEKEKEKEKTNIIINEIEIKDIVENENENENENVITVDDIDDIDIGLNNDYYSENKNIEQNSPKNNDTKNQIDNGFHQMQMQIRSTIEEQLNVFVTQIKLLFIDDYKSLYPDHPLLLFHLNDFHLYLNDWSTNLSSLYQTRLDVKYFNNYLACWEPLIESWKFNFDYHWKQQSKVLLISSDEFANINISAVFLKTLLHQLDSLSHEYKDESYQRKSSYTVLELQEEKNKIENKPKIEDDINENITEKKEEEKANKLQTNYQSKVFVPIRLRNQTGEEITFWSIDPKGKESSRKTLQNNQEEALEFDCFNRYHQRSFHFESQTDYFVQFNLTKNPKWESNRISLSSLDETVHLIGRSENYKVVSFIEVHQDVKVCYLRSPIQIINKTSIPLEIFHSFPKDIQESIGVVNSRTSFTIPLVRTPIGQIFWRPKIESEKTQQSEYRLGHIYYLDGTHETLDCTQLFQSTKMVKCEHKDSDEKSIFFLLKIQKCGESKGRYKKNQDLDWSFWKLKIRPPLIIHNYLNSYLDVYIYEPDKEVGETDSKNEEHLKKNISEKNSNKNMNLIHEQNFKQSPSNDADDNPDYIENSTPNDDIFDHLSNRNSIDQAEKYKEYHHISKFGEITKSYSFYFGKKQEIYLRIQIPGYSISKKFTINSFKKHSEYQITLQDTKKQKTFDVYAENWSKKLGTEKITFYTKFWMINKCGLSLKFYQQNLVIHPKKTAKVYAPKSLDKWKNNNLKNQKATMVSSQSVYVRIPKTRWFGFIPKLGILHGNLELFESHTKETSITLKDLYRSIKKEKALKEKKKEPIRLIEFIFSSQKAPQNLNMTTLITISPKFIFLNELPRSLCYKTKESKKSKPHSIRSGEFIPFYFSSQNPTKRNSKYVRVTFKALEKKEHENEKQNENIQIENIQIENIQNENIQNENIQNENIQNENIQNENIQIENEIENENENIQQISQYHVPKDQDEWGWTSLFDLTILGSIFFKILNLKNNTFYFFRASSYIEEGIHYFVFLPADKEEPLYKIRNNTKIQLAINQSQTKFTELIPPKTEIVYAFHNHCKKYNLEIRLGSNFKNSKPLIEIEFNATKHYYEVKYDKSTFLFILYYQGQTLILEIQRRSKKFTLSKKAEINAQMAVWSSRQSIFDKKKSPKEMIHSFQVLAHLPGIGISVISPEPHELLYIFLHDLEFNFTEKNNDQTISLVLHNFQIDNQMNTLFHVLLQRQPSEFPEPFLTFSTWKTTKYKQINFFHLISCEIQDTLLKIDDEIILALLDFFEYLDISILPDKNSGEAKQAEYEKMIAGNDPIKSCFRFQKIERGKNNCFIKNFHINPIRIILTFEVSDQVQKSKRFATLRHFGAPLIHFQDSKISLSGFILQNTMQPKQVIIQNIVAHYKASATKNLLKLIGSVDFLGDPVGLFENIGTGFYQLLEEPIKAFSDDPLQVYQGLSKGSQKFGSHLFDAVLGTTNKITGSVGNGFSRLTFDDNYREKRRKIMSQKPKHFGSGLFKGTKSLAYGIGSGFTGIFKQPIIQSKKDGVPGFFKGVGMGLVGVITKSIAGATDFVTSFGQGIQETPKFFDPKTAKRIRPPRYIGPSKVIISYDFPMSLSQFFLSKFRDKKYPNELCLVHVQLEKGERFSIMLTDYRIIYFVMHKKNKEMPLTRISGMRLYHCILDLEYWKDKSRKTKKTLRFTFLKEEEASYFHIKLKSQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHH9</accession>
    <name>A0A9Q0LHH9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHH9"/>
    <dbReference type="OMA" id="GHVVETN"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="144" mass="17094" checksum="D39EFB8D43C97FBF" modified="2023-09-13" version="1">MILFFLIVNKLGQTRLAQYYSEQFSQEHRIALENEVTRSCLARKETDCSFFEFRELKIIYRRYASLFFIAAVDDDENEMGIYELIHCLVEAYDKHFKNVCELDIMYNLDKAYMILDEMILNGVIVETNRANVLQNISKFDSFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIV5</accession>
    <name>A0A9Q0LIV5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase 45a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_08916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIV5"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="7">
        <location>
            <begin position="113"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="8">
        <location>
            <begin position="400"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="688" mass="80352" checksum="000E504D883EBF7B" modified="2023-09-13" version="1">MDFITNTNPKKVKVFIFGVVISVAAGVITWKLFKNNENENENENENENENENEKENENENENEYKNTKNNLYKLIQHIKICNGLDKRSGLVITNPNKTMTTTKATTTLSILKEYTETLMDYLNSLYPKEKLERNGIILGYDEDEQAKKYAQIIAEIFVKNQINCEIYQEPIPIGLLSFSVKFSQFVAGIMITGSMNSDNKFIYRIFWNDGAELSFPHDDIMMQLFLQRLQTSISNDLIENSRQSQEMETTDNSKLNNSQIIKNTREYYEYLKDNFSYLNILKIASPISISYFPVNSSWTKWIQTAFSWFSVPVAVIEDETSRELRRIFKNEFSKLFGHVTRLAERKDSNIILLNDYDCGRLFVFEKIDKGWYFFTANEIGILLSWWHMINFRKLSPEIETKNVALINTITSTKMLEEMAKKEGFQYQESLPGVKWIGNCASKLQETGVKFLFGFDEDFSYLTGEKSLYRDGISAATAISELANYLNHYKKQTLKQKYDELKTQFGFYSTEKGIIRCQSKDFTNIYRNIFNRIRNGGNYFKDLDGVSIISIRDVSQNFDSSTRDKKCKLFTNIVPNSRSMKFNNFHQSRLSDITLSNAKKQFQDLDRLSFSFQKNSVESGNEILSFKFVNNIIATICWFESEEESVYYYLEGSEKFYTDKFNKNLCDFTETFIEFFFQPSRNNLVISQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIY5</accession>
    <name>A0A9Q0LIY5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIY5"/>
    <dbReference type="OMA" id="DRHSFAI"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="114"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="188"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="240"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="4">
        <location>
            <begin position="433"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="509" mass="55804" checksum="7B21A926DB540B91" modified="2023-09-13" version="1">MGNDHSYVYAWGKNDTHQIGMKETEKDFKVPVGIEIFKEPVPVLSAGCTHSAAIMIVENKRVLYVFGQGYYGQLGNNSRESCEHPTPLTFFDNLPQLNSVCCGKKHTLALLENGDVYSWGFGQDGQLGHGDLSESLVPKRIESLCGLGVCEISAGAFHSAARTKGLRGKVITQIACGATHTLVLTNNGEVYSWGIGDEGQLGHGERKNCTEPKLIAQTEKTKVRTIACGNAISAYFNTRWELYVFGNGSLGQIGNGENSSVSKPTLVSGLNNETITQISCGDSHIAVVNQSGEVFCWGNGVHGQLGNGHTKNLSKPLKVTKLKDAKISQVVCGTDFTFALISEKFGLPRFIPPPNLPQRQVQDPLNQQNDPNLNQNSNQNPNQNGNVNVNLNQNQNKISEQDLEKFARLKVPITDAVFGIGISKEDFGVKIEKPPEAYLCPLSHKVMDDPVFCADGFTYDRESIEKWLSMNNISPITHHLLPNKDLLANNNLRAQIKSSKWANYGKDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ09</accession>
    <name>A0A9Q0LJ09_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_08783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ09"/>
    <dbReference type="OMA" id="DWLCNEL"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5073375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="180" mass="20320" checksum="CA994A4AC9E35166" modified="2023-09-13" version="1">MGKLFSKLFSGLGKKDMRILMLGLDAAGKTTILYKLKLGEVVNTIPTIGFNVETVQYKKINFTVWDVGGQERIRALWRHYYNNTQGLIYVVDSNDKDRMDEAHDELHKMLAEDELKDAVVLVFANKQDLPNSLTAAEVAEKLALSSLKGRKWYIQSTCATTGDGLYEGLEWLSKTLKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK86</accession>
    <name>A0A9Q0LK86_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK86"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="181" mass="22129" checksum="8A97C02BBFD90C93" modified="2023-09-13" version="1">MIYSNRIINPKLYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIEIGIDYFQLNQTNPNLFDLLINKFNNQNLQLKLKEEKEKEKEKEKEKEEEKEEKMKKKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKS0</accession>
    <name>A0A9Q0LKS0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKS0"/>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="19480" checksum="045EA0F5B6270A8B" modified="2023-09-13" version="1">MDKIIIISIIGNGGVGKSTFTTQFCYSKFIQYYDPTIEESFRKQIVIDDEILIIEILDYYYDSEWNYNFQQENYEKSHGFIVVYSINDKNSFNELENYLNKIYKYKKHGCPFYETSAKTRNNIDETFFTLLREIRKYPFDLELNPKSNSNSNSNSNSKSNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLN4</accession>
    <name>A0A9Q0LLN4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLN4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040448075" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="863"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="468"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="916" mass="103370" checksum="ECE8EA4E04DB8BF8" modified="2023-09-13" version="1">MKSILFFSFFFFLIINIFLIQSNQNQNQKSISSSLISPILTEIKTLTETTRYYSTLDEAWIWNLLDQFPSSSGSWFGWSVSIYKDVLVIGTRYLNQVFIYRYNGTNFELEQTLNESSVTHFGISVSVYENVIVIGADYANQVFIYRYNGSIWNEEQILNESASNFGRSVSIYENVTVIGTYYANQVFIYRYNGSIWNQEQILSESVSYFGSSVSIHKDVIVIGTHSANQTFIYRYNGTFWNQEQNLSESALNFGQSVSIYENVTVIGAYGAKEVFIYRYNGSIWNEEQILNESASNFGGSVSIHEDAIAIGASAVNQVFIYRYNESIWNLEQILNGPTSNFGSSVSIYENFTAIGAYVINQAFVYEYNLIPQVNIVNCSSSFSSFDCYWDEIQITTLEYQINYGYDWIDIDSPILEDENVYYQQFNSSFYDNITGNEYYSIQIQACNNVSMKCGESSSLINLTTKIDSVKDFQLSNPSNNSINVTWNYPNVQINEGIAHLDHYNLSYLIQSQPDLISFISVDNSSLDYFLNNFECENDYNISICGCRTQECEGDDKGEIVESSISLIFGEVTNFSCSILYSIDINCNWNQPINCSIPFYYNLTYQSISQNDSGNYQPTSTNQQFTVQLPNQEYQINISSCNSNGKCGYISSISITTDNLPAAPTIYETISKIEEIEFNFTKLTNANNYSISLNNGTNWQNFTSLNLSGNEVIGIISGISGNIEYNISIRGCADLNCEIPYLGLPSSIISTRAKLGNITSLNCYAIINGFACSWDSLILSSGLKAYSFKYNLITICLTNLLAPHYSITSGLEGGEYYEISIYSSADLNCSDNEYSGINSTTSITILSPYQPTQSTDSNNSNTTAITIGILIPIIIILIVIIAILLYQKKTRKKQKQTKNLNQKQEQEEKELQADLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLW9</accession>
    <name>A0A9Q0LLW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab5 family gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLW9"/>
    <dbReference type="OMA" id="YHYMEGS"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="23762" checksum="0A0ED9BE2ECEE3E9" modified="2023-09-13" version="1">MNLIKTYQFKVVLIGESGVGKTCLAIRLTKDLFQQVHVSTIGSSFYTKIFSFKENEEIKLEIWDTAGQERYNSLTRMYFRDAVGAICVYDITDKNTFFEAKKRIQELKNDLPDTTILLIGNKVDVKDQRKVKYEEAAEYAKENEFLFYESSAKSGENVEESFKALASLLNQNNQKSKKEDNIDISFNQKPQKKWKMLLNYSNSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM71</accession>
    <name>A0A9Q0LM71_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM71"/>
    <dbReference type="OrthoDB" id="192402at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="252" mass="30353" checksum="822E2B6350CEB0E8" modified="2023-09-13" version="1">MQNQIEIKEKEIEKEIEEEKLKCANYKLIGKESYIPINQKDFQKLKKSELISTPFKTKKPLNEINLIFEMLFNEILLIILSYLSPGEIIIFSLTCKQAQMICSDYLLWKQIAIKFQDYFKWDSFFYDYNYYNYPNIELKAIQFKIQEKNQNNPNQKQIKELSKTNEKIKNYFDNSNSTTQMGIYNYKQNFISIKSERLIYIQNLQNPKQKIEKKAKMIYKEMKKQNNNIFILKKVKSITIILTINMVQENIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LME8</accession>
    <name>A0A9Q0LME8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Importin subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_00706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LME8"/>
    <dbReference type="OMA" id="THVKQAT"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="957"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1038"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1088"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5074078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1149" mass="133498" checksum="E9FDC112D8029693" modified="2023-09-13" version="1">MDITELLLQAQNSNNQIRISAEEILIKEKEENYISFIWLMSNELISEEKPLKTRQLAGLILKNCFSSKDVQIQNKMYNDWLNQEQETRAEIKRILFVSLGSKHKIIRHTTAQIIMNIALLEFINEKWNNFLSDCIHFATTNPENTNIFEGIFTCIGYFLENISQMDIIYEIKEIDQVLQFIVNVLKENPDTQIQKSTLISLYHSIDFSRNVFENQEDCDVLMEVILNGSQHQESSEIQEISFQCFTKIGFLYYKILPRYIDKIYQSSINSIKNDNNASIQAIEFWSTICEEEIKLGDSEEMNHFVHDCSFHLVPIILESIKNQTEYNDPNEWTKSKAASVCLSLISSTIHDEIINYVIPFVEENIKSENFRDQESAIIAFGEILEGISEEKSKTFIEQISSILFELLNHNNPQIRDSTGWTIGKICEINPIAIFPRYEDLVQKLLVLLDDTPDIALNSCWSFLNLANSYSYFQDDPLFDSQFPQILNGLLICTERKDADLAGLRVSAFESLSANVVSAPETCIQIVDQLTTSILEKISNSFESNIFEFQDQTSKYQTQSGLLLVILSSTSRLKEQIESHIPTIFLIINHIFENDFQDLWESCLLIIGSLLNIFEQQIEIFIKPIITQIVNTIQLNNQSNSFSIASAGVIGDLFRYTSSLVEPFFDLIIKSLIQNIQNKSIDLKSKKIFISCIGDSCISLPENSIKYYHLIIPCIKNLVDDLLESQKQKQQIKQSNQEILSSVLYLFFAFISSLNHSYFRRFNQFLIDLIRIIEEITGFEEISEDLIHLTLNILVEMIEKFDQKVKKMIQKPNIIQFLNFIESFDNENIIEKRNYFTELQEELQEQVLLNFMLLEFISAIIALLILYEIIRTIKITGSTWKNLTSRFRILILSSCFLELILSAILFIVSFNWKSAFLVLFFYNSLPIWLQFCTFIFYILYLAKTLYMIEGKQTKLKKYLDLIFSILIIVCFIIVILIDYFNAKSINEGKNSLDRNILSGLYTIVLMLPLSILFVVMGVKYYKKSKDYLLVKIQKERIKYTIILIVIDGSIFTTFLIWSLFSAFEINEAIKKIENYLKNEEYSKYDTSVFFTNFVFVLIPAFVLFIILHRILSIEKGMFQREENILLAEGDDDVIDNFNGGNEYKLFDVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNQ1</accession>
    <name>A0A9Q0LNQ1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_06273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1319"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5076277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1752" mass="204878" checksum="20373F8B71C7C7C2" modified="2023-09-13" version="1">MQHLKNFVNNKILKSPNRIIAYILSKVLGEYVLSGFNAENCSPSLGTKNISVKLEKLLFSPIKINQHLNDFDLPFKFVSGSIQMLQVSIPYSLSSCLVEINNIVIKCQFIKQFTSSETIPKEEVKKVEIPQEENQGIIKKAIENILNNLEINITNVILILEIPEENNATYKIELDKISFKQSKISSEIFSSLKLKDKKNIDNSNDMKNFIDLNDLNDSNDSNSMSDIDDEDEDDDDEFILVSEFDENNSSQSYENSDLLLIKNSLSKNITINHLKISSEFSNNDNENKKKSILFTNEKEIQIQIIQDQRNPSQIEQMKKQNKETEKLPNHFQIKLGEIELKTDPVQLNCFLKLLNTRQEIAENHKYENNKENHNFNDFDNDFDNDINDNDIDIDDDIDDEMFKSFTESVVLTEKIENKKVAQKINQIIVKDQIKEQKQTIKELSKSFVHFKNTFSDLHQPEMEKKEKLMESIYDLNKKKKIESLFEFSIKKCTLRLFYQDSGKENLFLENNLPENTQSFLQIQMLDFLLTFEKSQESILKFNITNFSLQEFVMDKENQKTNVNTILHFANDPKNFSKDIEIHMDETNKKRKLEFTTKNIITMIDLETLIRFYEFYNTLKIDNIPKSKSKSKIQSEEKNAQITSFNSNIFDISFSFAINSIDMELIINLTKFRIASEDISKNIIIDFKELDTILKSQNDNPNKKDFPEAFFQILNSLENSNPFLEMKLDRSTNFEFNEANFVQIENNNYIGKYPFLPFNNINQISNFHEKLSELPKQKLSVNIEKINFNLTHELINNLFLFSLEITKKIQKMEETKNLIEQNQKEKIITLQETPFEMEINITKILISIEQYENEQIPNVLIPANHSFKFSIDKINFIFIPNIYNENCMYIYLKCDDFSLIDVYNDCWNPEKMITSKILSKRISHSNSKKPILSFLFIQNESLNLLTNTNIISETIIELKMQNIKYSHVVSTDIITRLSYMIPSFTQQSISEKKESKIEMKTTNQKIMHLNIFQKNFVVEYFPITLPAALVISVREISLIQQKTSSSLNSLMNLKVSNLSVKLTDYQNHWSEKTKGIKPYFVEIIHGKHLFSQIEIKSQNSNENQNQNQNSNQNQNQNQIIISINNNDLHAKFRCDSFFAFLDIINHINYLLDIPEKYRKEIPEFHEQIISIPNFVKNSNQNENPKSSQKGNLFPNISSFYEMDNSRNLINDSIKLIKSAEIKTQKNEKFSVKWENSLSRKEITIQDSEYLNHPQNWMNEKKKKMIEENEKRRISQNKRDHQEYLQLKFLVLKANIVIRFEKLSANLKIFDGLDFPLEKIIKIEKENLEEIETQIELEKNYISDLNQSQKNIEMNNLEANENIFKVETKREEKVMNENIKIEENQEKTNREDYIEIMIENTTINLLLFQKKPLRKVILDAVIGKVLIQDHVSSSVYLNILSYMSKHKKPKDVLKPMAHIFFEIIDPLFDTEKLIKGTDELLLDAVISPLRINLDIRTLYFLSRFFSYFPPFYKRTLETVKIPPPFFQKILIGFLEFEISITYPLPKSLHAKIDRIHLQMPKLKMIGKNGFDQVMETFQNYYLKAIMTKKQILSIAGSLPGLNSFKNIGKGMKELITKPIDSYNSGGSVLSGVWDGINSLTKVILIEGLRSGKAIINTSETTIDMISGDSISENQQQDHEMDGIIQEIDEGFQIVRNDPKNSSQSKNHKNYFLKKIGNFSKQGLKKIHEKINDTIDYLDPKRKEERKDKYKKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNS8</accession>
    <name>A0A9Q0LNS8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysozyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNS8"/>
    <dbReference type="OMA" id="VYERCEF"/>
    <dbReference type="OrthoDB" id="17373at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF63">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040375288" evidence="3">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="134" mass="14996" checksum="093CD4FCD2FA3E1B" modified="2023-09-13" version="1">MKITIFLIAIFAVAVVYSISECDTAKYLENAGFSSTQVPVMVCIAKYESSYNCGATHDNTDGSEDFGLFQINSYWWCSGGPISKYDGCHNTCQSMFSCQTNANCARVVYEQQGYTAWYAYRSHKSECDSFVIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPG4</accession>
    <name>A0A9Q0LPG4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPG4"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="118" mass="14508" checksum="4F298971BFD0D17C" modified="2023-09-13" version="1">MKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYLNQIKERIQITKEIINEFQIGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRM2</accession>
    <name>A0A9Q0LRM2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRM2"/>
    <dbReference type="OrthoDB" id="10252212at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="23787" checksum="171532DF035467A3" modified="2023-09-13" version="1">MNEILFFGRNQYPKLFKNKSKKIKKPIQFKFENENEKQIKQISSSDFATIFLFKNGKAIEYLNQRNSKQNPYKIQIEKNIQKEKILIQNNPNQFINISSLIEDTNDRIIQDVVSGRDSIYLLTSNQNAYGIGLNQYCQLGFDSETLPKTEKPILMMKNVSKIFSGNFSSSVFLLNSNQELFGCGYNIYGQLGLGESRRKERKIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSC9</accession>
    <name>A0A9Q0LSC9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSC9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41226" checksum="5CE1FAAC6638D5AE" modified="2023-09-13" version="1">MSSGDGEAFVCLVIVFCWLAFGFIGGFIWLGVDQAYVSKFEKTDCKVVDKYLDYTVYQNSNDDCFGADTLNYISRFQVTYSADGNDYEEISCWFGQECETSRGKSCSIKGCSSGRKEGVCRRYIHTKKSDFYTKFEVGKTYDCWYWKDDPRYSTLKLAKPSYLWSLFLWIPSGLFWIIVFIYYCGGNLVDCCSCNSSSEGCLAAVFCCKCGKRKRTTRTYNYDSKPQIPKPIPKETTKEAKVKETKISDSDYDSSSTISSDSYFDSDSEKMRIKEELRKAKKIEKENNELPLQNIDSQKDITINYDFKPEYQENQIETIDYELKPEDSQNHIGPINYNIGNIAPDNQDPNSNQQNKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSD1</accession>
    <name>A0A9Q0LSD1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26s proteasome non-atpase regulatory subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSD1"/>
    <dbReference type="OMA" id="LECKLHF"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="225"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="424" mass="49129" checksum="5B863E7BE3A5B1C9" modified="2023-09-13" version="1">MISLKEKYQKAKQNKNEKEILKEYQEIIQTKTENEEEIKIKEETIIEIGEIFAKLGFGENIKNLMDSLQDFFLQLPKARTAKIVRKLIELINQIPNSIDLQIHVCSHWIDWAKKEKRSYLRQRLESKLASLYLENTNFQMALTTITNLAKEVKKLDDKLLLIEVNLIETKIHIELKNIPKAKASLTSARTSANAVYCPPLLQSEMDKLSGILHIHEQDFKTAFSYFFESFEGYSTIVLDPKLKKKYSDNIVGQTKFKFIEKEAISTLKYMLLTKIMMEHVLASKFTGREIDCIVKISEAYSERSLHKFNEAIKEYDKDPIIKNLLNSLYETMLEQNLLRLIEPFSRVEISHIADLIKLDTKTVETKLSQMILDKKFEGILDQGAGCLIIYDETIPDETYKLSIEIMENLNVVIGSLYQKAKGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSU6</accession>
    <name>A0A9Q0LSU6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSU6"/>
    <dbReference type="OMA" id="PMKHRER"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009093">
        <property type="entry name" value="PRK12429.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="244" mass="26823" checksum="6917146570B2C404" modified="2023-09-13" version="1">MQRFFSTITKNPGRLFQQTAIVTGSGSGIGRALALGFAKEGANVGVTDLNMKGADETVEMIKKQGGNAMSAFMDVTNEKSIKEAVDKVTDKYNDRLDVMVMNAGIQHIDPIHKLDQKDWRKVLSVHLDGSFLCTKEAVKKMYPQKSGSLIYIGSVHSKTVSKLKAPYCSAKHGMLGLARVVAKEAAEYNVKANLILPGYVFTPLVEKQIPEQAKELGISEKEVIKNVMLKDTFDYTFTSLNDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT62</accession>
    <name>A0A9Q0LT62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Golgi snap receptor complex member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT62"/>
    <dbReference type="OMA" id="KQIDGNC"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="215" mass="25529" checksum="EB47B62D69E87B76" modified="2023-09-13" version="1">MNLETLWKEGKQGIFQLESLLEHLERSSEISPDSRKEVEEKLRILTQIITSSQTLLERTIENKELWRIRISEMNSKFFSLQNSINSLFAKYQEQQQEKKERDELFESIRLRRNQEIEINVGTLLSNEDKSLTRSEQKVENIFQVGSGILEKLAEQKDRLKNSYKKVSLISGSLGIARNTLDWIRDRNISDRRIVIGGMIITLLIFWLLWKYWIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTK7</accession>
    <name>A0A9Q0LTK7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000049">
        <property type="protein sequence ID" value="KAJ5078697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTK7"/>
    <dbReference type="OrthoDB" id="2659088at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="61"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="135" mass="16386" checksum="FD53854BDC5EDFA6" modified="2023-09-13" version="1">MESLLVRGYLYLVADALLYPRTKNYPRNFFFQFSDSEEEIRDFDSIKFEELQATNNEQRLEILTNFGFQDFLNFFQEYSLMVDKAYYDLQNEIQIVIPFKKPRGCELNQEEQFFNARLSSLWIQIEHYYGRLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUH9</accession>
    <name>A0A9Q0LUH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000045">
        <property type="protein sequence ID" value="KAJ5078754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUH9"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="325" mass="37411" checksum="E5F55E9892C3C601" modified="2023-09-13" version="1">MMVMLKILKVQSRRKQLFDMLISYESPILEFLIIKTNVCRCRFDNSLFRANSVANKMMTNYSRLIVNEYMIHILQKPTQEIIELLSNYEGNPFEIYPNPDDRESFNKENLERIQIYAKKFLDSILDSISKVPLGLRYLCAKLNEITSQFFSESQYVAIGGLVFLRLICPTIVAPNVFGILDQKEKITPKIRKALVVISKIIQSISNGCLFKDAGELVLLNEFVEESIPRLKGFMDSLIKPVYCLEPKPNDELNENVVVVDQKENDLVVFKVSENLSKCFLVSSNRFDLERKIIENIPIEKCSLPSKNEIESALDNIYNLDNNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUM4</accession>
    <name>A0A9Q0LUM4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">32 kDa heat shock protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2020" mass="240914" checksum="388CDA5742DBF4AE" modified="2023-09-13" version="1">MEKQELMPDTLYYLRLNSLSAQAAWEIFQIFTTQKVKKLKKKSSSFFSDRKTLPIIQILISLAPQISSEFRLQVLNDLLLISIHVEDEQTIDYLINMINQIYRDSTTIILEFFEKNKKTHSLLAPKLFKKLDLSKWNFVHKDYDVISKWLTDSSISVYEISSQRKHLFDTARYILTNLNWGFRDTTHIDKENFEANTKTVLEIAESLYFVHPEIHRRLLIDLGILWSNLNLKPKKKTKNPDEKKQKGHNQEILKEINKWMILMSEKLDIFTQFGQQITKPLKCSEFHQKFTEAKDVKTLINGYNNRFLCYLYLLTTNAFSVIKNTQIKRLVKKLKASEEYESLVFKLLTKQILNLLTKQKEDQNNDNDNDNDNENENENRNTNITHLFEGIFDTFSTSTQTNEKSNPVLIQRNIAALHLCLWGLKQKKGSCWPENISQNEALRYLNSQGINVRVLQFMEPSIPVSEVMKFWIDISLESFKKHSNDMSNYYLLNEIFKISHFFGMSQFLWKCFYDHPQRKENEKLILESDPKKIGNFSWCFLGVLLLSTIENNNTRLENGSNLVSRRRRFSNKVETFMKTWDKVLQRLANPDVVDENLFDLLPIILQMIFFLFFSCDTNRGPYSQIFEDDQVMFSVGDDNWFGNILFTKYIDSFRKRIRQILKLSLQRDEQQNRFPLILASMKKWIKTEVVNDLEEQAMKEKKDLQFHFLEQILNSFLHKKIDFQNWDSWFTELQTFLWFEFVDHNKIFRNISEYLKFANSLQKSIIASENENNENQESKPIVNIFFDKIIIESKTDPNLKMQKSQKNLKMQKSQKNLKSRKSLKNLKNQQEEKIPNFLNFDLTRPNENDQNTSFSNIFKSKLAELVSDYSEPYVKNKKENEIFLREYISFLYEQKTSKLNLQSISNDNLRIQQQTQSQRNPNSDFQYIDLIQKETEQQIKKNFSMTKNKHRKITLEIPSTIQDLDKLANLIILIDNLVDKMMESFQLSFSSIGNEIDEKSGKKYRDLNGSIQAIFETSFENISNFPISRQKILERNLVKMGEFLFELIPSDTFRFLIKNLLKKPSFHDLIDPIIDPMKVYKGDFLIQYENIILSNEKIHYPILRKFNFDKWVEKNNDLELLKESVTRILKFFELKDQAQPDIFKHALDSFGFVASYDFPNIFDDILQKILFSSFFDKCPQKVWQIFLISWQKKQRSFDMIEKAIGVMNSKVSELRFLFEKERRKANLSTKKRRSFISCFDLACLRNIKLFCENLFSEQNCKLLDSFYIEKLEKSKSKSKSKSKSKSKNQNEHFLILNNLLIRLSNLYNPWIARNLPYLDIKSNQMKFNDCGPPFDEENEESKKAFLSILRSFCKVLNSLNKMFPERFFLHNFFILFAKHKILFFYDPKIYVTAFNELNWETSQKLPFNIVSEFLSSLIILEDYIELTFAMLIKTNFGIGKNQSIKNLNLDLVNKSVYYQFCFRLILSILIRYSFEEFTLEKLDFVKQQIDKSKLKKISSEFFKKTLEENKGIIIDQLFWSEKNRKKERNEDTMLDYWEKMEFPSKFVNPEDKILVIYLYLKNMVPVLDEKIMNPKRGNNSEQEYKKQQIIRENIELNFLEFFRFICDHLRNLANDQNLEKLFPQDNLAVKITQIFKDITKMAFEYVISQSHSKANRQKLIMELFEIILVCIYQNQSKTFLTLFVDKFLSLLEDYHEKMDLYFYLFLTQYLFANSPPLPLSRIFNFVAKFYLDKLIFLENQNIQKKINPNAILDKMSNIQEIYQTDFNQHCIENGAGISLYLVAAYIIHDEQKHNNIANIHTLSKYITDLFSWIRKIKFKSPTDEYQRLLLLDFTFSQISKLETILDAFLNQNQKSNSNKNSNQNINQNINDLYQETQSKILNQILEILELIWDDFFLSQELSLNYKLIYAETLYFFKFKRNRNLKPMVLFEQEKIKKVVTKERRSQLSSFIEHRLDKNIRKEIEQWIRESRIENDFIHFSFYYRLLISKIDPNLNIFRERIKRLVDGLKIKFEISNQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUW2</accession>
    <name>A0A9Q0LUW2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myotubularin-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000036">
        <property type="protein sequence ID" value="KAJ5079150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUW2"/>
    <dbReference type="OMA" id="FENKETY"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14507">
        <property type="entry name" value="PTP-MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="105"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="233"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="320"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="518" mass="61042" checksum="DE678ED8F3769F8B" modified="2023-09-13" version="1">MTQYIIFQPNENNTFYDKKISKQLPNIPLGFINKADKIGGQKSKGMYSYGIEVKCKDFRVYRFYFPKVNHSRRFIFSKLVERAFINDLRLTFSFFHKSNSSIDLGWFIYDPLKEYKRQGIESTQKSKWKIVDWNSEFGICTTYPKYLVIPSNISQSHLEKLKKFRTKQRIPVLTWRNPKKLNTICRSSQPKVGVARSKNESDEKLILVISQKNPSKLPLQIYDCRPKANAVANKAKGGGFESLNNYKTSELTFLGIDNIHTMRESFTKLINSALYSFNDDKKWFAELDNSGWLIHIQKLVYWAVKGAKLIDSDYSLLVHCSDGWDRTTQICTLIQLLCDPYYRTLEGFIVLIEKDWISFGHKFSQRIGHANEKSNDNQRSPIFIQWIDSVYQIWQQFPHAFQFNEEFLITIYEHSISLRFGTQNTASLWTFIYDHKIKFLNEVYEEVDGLIYPSYSLRHLIFWERLYLRHMGFVGNFTSLIDSNRQTEQNAKEMIDNLQKLISKLKKSIEELKEKLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVT3</accession>
    <name>A0A9Q0LVT3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVT3"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="741"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="843" mass="99403" checksum="AC30583932075277" modified="2023-09-13" version="1">MFDFDFGEDPILDENLSLLIEYTKKEDLENLQKVLTEFESTKELRADVNFLNEDEQNCLHIAAKYSNSPEIIGFLFSKGVRYSKDHFKMTPLIYSLSHHEPNLETMKILFANGAKITETNPKKIPLLFVIIKAVTDEAIYDFLIEKGADIKQTYRDRTLLDHAILLDHKIEFLKYLIKKGISPKRKPKNTLHSLFHKMGTTKSTSKEVLDLFLSHGIDPLADNGSNTLLAICMRNQQNIEILKLILSYLSKERIQEYETKNPEYSLLFIALESRSTFETFKILIEAGTNINIMTSKGTPLLNAIERGLDPAILKFMIENGALSINTIDQSMPNQYLLNRTLHDLVRYKRDRELIDMLLKKGAIATTDIIISSIEDFDVFIYFLDLFPGNFPIVDHFWTISNHRKSLTFEQIKIVLTYLKDINEVNKYKETFLHRFVRSKLFNKEALDYFISKGANLFHRDDSFKTPFEHYLFGNCSMYEKDTQSMKEIIRIFIKQGADVNFIKPENGNHILHLLVAYNCFHIEVWEELLPYIQRIDPINKEFRNPEEELFFDLKTYEFEDDSYTQMGFNLLHFLKLFKSYSEDYLNFLERQELKDLEIGFACGSKFMVHRLILEKRIGKQNIDKFIQFSSQKTKEEMMPFLKWIYSGQFADEEFEKKQLDEFNKAIKEHKEISDYINDFRYEKFDATRFLVYEKQKEDFNHIFNFLKEINAVETEEEMKAKSLTSGVINDLKQLYQDEDSKDFVIVTEKERIKVHKLVLMARSELFRGMFVSVEDKTNQVSDYSGKSSESISQLIKFLYFDKFDNDLSFEVIEDLKELNIYYQLNQNSSFEKLLQFQKNFKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVY2</accession>
    <name>A0A9Q0LVY2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_04753</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVY2"/>
    <dbReference type="OMA" id="QLANKFE"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040328473" description="protein disulfide-isomerase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="339"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="386"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5078428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="477" mass="54971" checksum="58F3005DD03EAB0D" modified="2023-09-13" version="1">MNFFFSFLIILTLLSLLQSKVTVLDKGNFKEIIEDRAVTLVKFYAPWCTHCKALAPIFEEASDKIEELGLDALFADVDATAETELAQEYEIRGYPTVIAFKKGVMYENYPGARTVEALISYVQALLLPPIFKIEELEKAKQFSKQFPISLIVFNENDDDEYFAELETMVEKKEFKKMKCAYIQDKEIAKEMGLEKLPGAILYRNLDSHTEKFEGDAIKDLKKFALENQLPLFEELSAQNYQEYMSSSTPLILNFIDPETKEQSLDLVAKIAAEFKSKLLFVWIDGKQMRQYANNFAIQSFPAMVIFDKIKEKRYYKLDPSEEEINEESYRTFLQNFLDKKLSYAVKSEPIPEKNDGPVKTVVYKNWDEIVLDKSKDVMLKIYADYCGHCKKMAPAYLELGEKLAEVETLTIAEIEGAKNDVGDNVDLQGFPTVLMFPADNKENPIVYSGDRSFEDMLKFVQENVHFKFELKGEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWA8</accession>
    <name>A0A9Q0LWA8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000021">
        <property type="protein sequence ID" value="KAJ5079930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWA8"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="362"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="283"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="467" mass="53925" checksum="61DD72B837665D1B" modified="2023-09-13" version="1">MMIPQEVARTVSAGTLLKTDFTGEFVNLYSRQNGKSYIKKTIAKLVDDFCKSDLSLDVDPSDSQFEGDAQQNISNFQSQLDLFANAILTSASSAPLSFKLFATLIKQNLIVRFPDHYISVICTFILLRYFCEALKNPKQFELINYEPSPKAKRGLENIAFAFEKLAIGSTFGANLNQYAPLNTSMIKLFSGRSKFINEISSLNINSFDENDIKKEMENAKLYSQKNSFQGKKEPKYEINLEELEYPFLMIGSLLFIKKNIPFSLMTRLGTYQIEKNHREIYELNQEMLQINEYLDDLEILLNNYKDESKSVEKQLILNESTNQNENQNQNENQEQKQKEVIDYSEMSDSELKEVWGNLSDIEATKEGNVYFSKTGGTFSWKKRYLVLKKNILAIFSSQSSYKDSRPKETIVVKSSYLIGFSKKVTYRKKSTFQITIPNRSHPLSFAFDHLTECEDWIHKLRSIRKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY26</accession>
    <name>A0A9Q0LY26_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY26"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="369" mass="42983" checksum="5A74CFF43D1F4817" modified="2023-09-13" version="1">MGNQSHFRKNENISDRMIENLENKEKSTRKYIMENIREGDLDSVFGLLPDEIVLYIFQYLRKDYLHICSKTCTRFFFLAYDFQLWKKIEVSLASQAITDSKVKSAIRHSLRTEELKINQGFSLTSKALSYLTQNARYLKRLSLSRTRKLKTQEFEKITKTFQNSLEELMLYDCSFLADNLDFLADFTKIQKIVLHSPEIETIPEKISGNPNLNFLEISRSLLSMPQFYLEKPPLSISSLNNFTSLNVLKINFANWSIFPNEICFLKNLQALDLSDNRFVQIPKEIENLKQLLFLNLSNNQIIELPTSLGSLSLLDYLDIRSNNLEFLPKSLLNLSNLSCFLISGNNFIEAPSAIYTGEIKFIWDWLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYF8</accession>
    <name>A0A9Q0LYF8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF913 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000012">
        <property type="protein sequence ID" value="KAJ5080145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYF8"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF913" evidence="1">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="311" mass="36106" checksum="C2ACCF5A9FE20AC0" modified="2023-09-13" version="1">MSFKLISHLLPQNDTEIDEFITNSPMKKQINEILLNHELCEKNPNLFTTVIEILYQIIAQPLYIPLTISAGIFKNLSSLIHKIVPNSSNSLITLSRILNRLTSHEQGQIFIKASKIYQPILSCLVDYKYLPILSKRTLTELGLNFEFVVQYLPEILEPMINMIIEMIKYIYQGIYSNTIREQNKEKPKEEVDSIVETYIGGYIENISQFLERFLVSYNHTNMFIQKRGLVFFLNILLSDEVPTNFFLSTGTEFFNRLFQNIGSQKISEVSQVLVNQTLEQLKKLNIDSEFLLKTDSKNQLSRFTSLVQLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZ72</accession>
    <name>A0A9Q0LZ72_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein fam98a-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZ72"/>
    <dbReference type="OMA" id="CDWVNDQ"/>
    <dbReference type="OrthoDB" id="512356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF1">
        <property type="entry name" value="PROTEIN FAM98B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="354" mass="41522" checksum="B036202F4D8E0F2A" modified="2023-09-13" version="1">MENLIIDIKNNLNEIGFIELSDSTIKEALEKGDKSQIFNEIIQKLFEEIESISETNSEVENKEISLNEKIEKLGFPFEISTLFKSIEMNYQLLNFLFTELKTCRLINNKTKINIYRDSKTEQNENENEKLEEKKIKSLLFSLCNLLEIDTSEITNYESILSEIDQKIQELLQNYPKEHLQNHLISPEDYSNEELKEISNYLEFFDNDFQTRQKMLLERLEVTLQAFLWSEQGKKNQEKILEIIDEAKSYLNDCRSKIGILDLFCANDDILSIRKTSDSTVKEISKVSGVLIDDNVPDRGGRPDELKDTRMPAFRARSFQNQRRSPQNSRGRRSPQNSRGRRGRFDHSRRRGGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R430</accession>
    <name>A0A9Q0R430_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ada2a-containing complex component 3 isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R430"/>
    <dbReference type="OMA" id="FEAQKCE"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="819"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="836" mass="97006" checksum="F0AE98C72763C949" modified="2023-09-13" version="1">MGAKLVKIQKAIDQEDSIVLKKLITPKTINATDGEHESPLVYAIRQKKYVVVNFLLDFPGININMIDKHTNFSALQHAVLGKDTEAMDILLKKGADPNVQDSNGRTPLIFACVGGNEEACNMLINAKADLNLKDKEGKAPIHAAVVSSARNINVVKLLLENGAKIEEKDVKGRTPLHLAVFLSNFQVVKLLLDKGAVFNYKDYTLIHVVCLGGKLIKDWVTLEFNRKPKDEEKPKENEKENEKENEKKDEKEKEKKDEKEKEKKDEKEKEKKDEKEKEKKDEKKKSKSKSKSKSKSKSKSKSKSKSKSSDSDSSDKEKKKKKKKDEKKDEKKDEKKDEKKDEKKVEKKVEKKVEKKVSIHQEKMEILDLLFQKGIPIDTFDQNGEMPIHIACSSGMLEIVEWLVSHKIDVNALDQQKVSPIHNACLYGHLDIVKYLLANGAKPELEDPKHGTALETTLRSQKHFENKWKYSNQLFEQIAEIISQKTKEDIQDLRKKILQPKFDIKENSSIEFQKKMKLKREESLKKRKEREKKKKQGRKKLSKIEKQKKKENQKKKELEAKKAKESQEQDEKPKDEKPKDEKPKDEKPKDEKPKDEKPKDEKPKDEKPKDDKKKDDKKKDDKKKDEKPKVEKPKDEKPKDEKPKDDKKKDEKPKVEKPKDEKPKVEKPKVEKPKVETKKDEKPKVEKPKVEKPKDEKPKVEKPKDEKPKDDKKKDEKPKVEKPKVEKPKVETKKDEKPKDEKPKVETPKVEKPKVEKPKVEKPKDEKPKVETPKVETPKVETPKVETKKDEKKDEKKKDEKKKDEKKKKEKKKKHHNSDSTSTSTSTSTSSFSDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4M8</accession>
    <name>A0A9Q0R4M8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4M8"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008536">
        <property type="entry name" value="DUF818"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05677">
        <property type="entry name" value="DUF818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="187"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="367" mass="42130" checksum="181CD09C97C62582" modified="2023-09-13" version="1">MGQNIVSKFAFVPPKINQGLNYENIFIIEIDKNKRIPIVWLFPENKSNSKINDSNDSQKQKEKQKEMEEKIKSRFSIIYSHGSSECLSMIEFLIEKFVKKTRTNFFAYEYIGYPFTQGKTSEKNIYKCAEAAYNFVTNTLKIPSNRIILFGYSIGSGPTIELATKKNCAGVILVSPLLSCIRSFLKAKKRLPNDIFNNLEKMPKVNFPTLIISGSDDQLIPPDHSQILYKALPNKSQYKLHMIQGGGHNDLESEFGSEFYGVIDDFLIYLSKKNPTLDDLDDSNFHPINQKLSVLDLDDSRFTTINFQNSIDSFTYDDIFCAPFILSQSQFPFFGDSCNLENFDTFPHSQQIEHNQNENQNQNQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5C1</accession>
    <name>A0A9Q0R5C1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein unc-50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_13469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5C1"/>
    <dbReference type="OMA" id="ETAIWEM"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="240" mass="28495" checksum="EDDACCB035472312" modified="2023-09-13" version="1">MIPLVENSERDTQSFSEVLKKQIQYENFLNSISQMKNLWIDPQNTYDQIKEQKQFQDTWGRKDCSFVLIQMFFIFISSIAYSVCFRISSFVGFIKVAFKSIFINYLLFGIFISMILRFLTNTFLRKKGFLYSEQKVEMRYAFDVHCNSYFPYFMITHIIVYPFIPFINSNSLFSIFIGNFIFTFAMSCYVYITFLGYKILPFLHKTVLFLTPIAGLLIIFLIFSLSRISMVKIFLAIYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5S9</accession>
    <name>A0A9Q0R5S9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5S9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="331" mass="37902" checksum="BB6A2D5A9D245841" modified="2023-09-13" version="1">MNQIETTETFLTQFGNNLNNLNQTILRHFVKSTADFVVDIIIDSSGPSLLEIPSQTFSLNQSQDTTLRSFLRLNCLGVTLISGKHILFSKSFNENLNKTVIQLLTSQTKLPIFEIGDELNGIINKCLNRGEATFEVEIDSLIDNEKIEEDSFQKRCLLQIDPYFVTLSQAEKDPILFSWENESTKLYLVKGHTNNDKLVLDKYILKCSSHILREIIFRLFYKFSEIAIKETEQETEFKLPEIKSYEQEKIQEDSQSAFAALGNFFDPTELDENIQQIPQKSIITNPNQKNPFLISNDIVSAFEEDHSFIPVSPFEFTNNSNNSNNSNNSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5V7</accession>
    <name>A0A9Q0R5V7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5V7"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="846"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="970" mass="112094" checksum="105610D3599C0B9E" modified="2023-09-13" version="1">MFQPNYLSKDYPRSWHSFEHFQYTSQEYPDEVFPQKRVAHSSVIYKEKMYIFSGFQIYSETFSDLYSYDLIDKKWKKEEQYGEIPYGRNGHSAIVAQDLMWIFGGADENEIYLNELYSYNFETKMWKKEQANSQFPSERVLHSAFLINEKEMAIFGGVNQQGNLLFDLNIFNFETKIWRTIQNTPKMNDEMNCFLFENRLYAFDDSFKKTFTFDFLNEEWSDSIENEGSFPKVNMGVSFSVIGNAVFIFGGFPEPKSDLSKLYLYYPHKHQFVSFILDDTPISRYKHSASVYQTENETHVLIFGGIHKEETCFNELHEYTFPKGFIPYPTFVSAGEIFEEKIYIYGGMGVGEHTTRALIEYNIEEKRWREIKTTGEIVPALYGAGHLLYKDCMLIYGGIVDEDISNTFYALDLRKFEWRILASGEKCPRLTLPYLFSVQDTLFLVGSQADTRKIELYRFDFTSKNFESLLILGNDIEYEETPPIVFHQNKLFVLLGKSVIWASFADPSKTAFEPQLIQLEPSPQMKILDGDEKTENLARTLCTPVVVNDKIFVYSGLGMTDDNASDLSIVIDLSEKTYKLITKTELKKPACFGYLPLVYSNNTIILFGGGRSHSFKDSNILSFLQLEPPPNPIFSDFEQLRQSQETAQTVFSIHTQTGRKEFKIHDAVLLSRCKKWDPNIKAAVISLFEIIGPDLVDHIFHFIYSAQISDELLESTSFDNLCAIFSIALTLGIDFLRRKCEQILIQNHLNISTCLELLVLFDSVESKNSKNSVLCLIAENQESLFAQFEQISKLSSTSPHLTQEIEACISNPDNFVVQKEFALGPKQAQTDFIEDMSKLFDSQRGSNFIINAYDLDAKHTKPINTHRDVLYARSELYRGMFISVMDESNSVTDMSNRSYKAVYSFVKYLYTGDLDQNLEISVLNELLDAWIYYGLTDNHLQLICQERINQIENSLLKKNQLKNNQENENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R624</accession>
    <name>A0A9Q0R624_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nnp-1 protein putative nuclear protein 1 nop52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R624"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="725" mass="84876" checksum="B1F3C70F2F40A98A" modified="2023-09-13" version="1">MFPQQVIQIKTIQQLINSLKSQIQLFNEETPPTLHSFANISVEQEKTKFSQTCHEIKEILEQGWLRIGYRTEEINRFLIKINKIISTNKERLEKQTQLNKSKSLIHKQIESSKQQTTINPKIRSKLAALESISKVHNLSLMNQLSEEEKIYLSTSSLFIEIRFDKEGDVDNVIIIFNTSEDSAQHIYAELSVNEEIKWFLNHMEKPKKNSGKKPEYQYFRILQRKIQSCMNLDQIYDNFGAEFVEQKKIMEQKFKQAFQDENHLIVQKCEGITFRYFVMKKVMKKYGEKLFKKFPEKDDEKNNQNQKGNNENENENENEKIKVEDNDNFDVLFNNENIEGIYEVTGMFEKNIQNVDIFTTTKPEQKLDFTPGIPILMEYAKMILDQQQISTGNYHSNFHGNGNENGYEFFDSRKMEYNSGIFEENQHLENQKDGNAFSKVFMHAPRDVDRSLEHILFPDLAEKNLFRRDILVGNISMIISFEQKFHSAVILKRIPFNDPSSLGKTIDLIKQNLLYNELLLSCSSKSIEDDLKSKNDTGNLNGNSSVKINGNYEQEQRQKNQMEIETISIGDSRFDQNSDDNLIQNSDDNLKNEKEPDEVDILGDNIRSLSIEVSSKPPKFMSFIFLRPYFTNNFLRFEIVIGTGFIKSALLFDNQTGDEIENPEILQKLKETHSIPETIHFIIEFLYEENSNENLNEKNNQNVKKRRTKSKQENKSKKENKSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R644</accession>
    <name>A0A9Q0R644_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R644"/>
    <dbReference type="OMA" id="RIQHYHE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="694" mass="83658" checksum="930D143DDDD48D7F" modified="2023-09-13" version="1">MNDKNNQNNSNILNQTQIENRNLNRNLNDFDFDLIGNNLSTQQLKNKVHYYYQLYLEELNEKQKTKEVLNQIHKQIQEKEQEFEESNKIYNQLIDYVNSQSLEIQNLNQKLENSFNENKKLNDLINQLKNIQNQKQLEMEEMDNEYRKYFEEQEKKIQEKNNEIIEYQSMKKEFLNEVNEAEKVFNFLQNENENFNKKISEYQQKETQYLSEMQKIEEDLQQQINTNSYLKSELEETKKSKEVLSQNLKRVEEQLSHLKNIEKSKEQDKMIIQKEYEQKINKLNHDFNNLELEFTSLQSRSEITKNIINQESNLKQRIQHYHEKYKKSKKENQKITMQNENLLLQVNHLQSQIDQIKNQLVPKNEVQSQNKNFHFSTQIQLLKNQIDSKNDEIMSLNQNINQNLYQIEQFKKSSKDLENQIKKILSEDENQRQIQFLQSKIDEASDLLKTKQAKIDTLNLEIQKKSQSVSQLQSQVQNLQIENEEKSNFLDKLQTEKEKTDKKLQQTQEKYSKVNEESKNIYKAFEKYKEHFQEIRAKIEEKNNENSKLSENLKSLELENSRILKEKNDLFQEIQLLERKLDNTLNSTSLSSFEKSKLINNYESKIKEIEKQNSSLILENQNYYSQIQIVSNQKSLLESKIQDLEKIIIENSEKFSQQKKQFKFQHEQKCEKYHQKLEQACKLLYFLKQKIQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6K2</accession>
    <name>A0A9Q0R6K2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6K2"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="271"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="326"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="403"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="496"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="599" mass="69692" checksum="038340D06058EBF2" modified="2023-09-13" version="1">MNDCLFFGLNNYPKLFKNEPNKIIKPIQFKFENENENENENENENENEKQIKQISTSEFSTIFLFKNGKAIKYLNEKDPKQNPEKIQIENIQKVSFGYSNEAILTIEGNVFAKGYYINPKNPKEFINISSLIEDTNDRIIQDIVSGGFSFYLLTSNQNAYGIGSNYSGQLGFDSETLYKTEKPILMMKNVSKIFSGSTSDSIFLLNSNQELFGCGDNNYGQLGLGESRKEETEIQKLTKIQNIPKGKIIDIQCGVSFSIMLIEDENENPKRKLYSCGYSQFNGLGKNENENTYEFTEIKSSLFENDDNILEISVGNAHTLVLTSKSKLIVFGDNRYGQLGTEDTKEIQLIPIQIELPKLRFNENISNYHISCGNNKSFLYYSPSSFSNLEEDLIKLFKRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNRIEKLQEIISNKSIKESNQIFEMIYSNNSNINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTDDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIIDEIKTGIDYFQLNQTYPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6W1</accession>
    <name>A0A9Q0R6W1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6W1"/>
    <dbReference type="OMA" id="SSHQRWA"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="4">
        <location>
            <begin position="333"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="764" mass="88754" checksum="ED6E93FA8D494A19" modified="2023-09-13" version="1">MGLLFTLSRDYFFPFLIFTIMVMSFFIPASIRPKQKDYEEMNLAYSEQENKGGLDGTLDGLFWFVQVSDIHISKFDPSYASTLENVCTNYIQSIKPDFVIVSGDITDAKESAKYPNRNQQNEEEWKQYKSILQNCGVYNSSFWFDIRGNHDSSTVLAKNAANNFFYDYSPQSTFLNSNGKPSVYSFIHHTSFGNYQFVALDLSIYPLVSGPLGFFAFLDSEKLDQLESNFDLNKNYYQLNQSIIFTHSPVAAIQKQSTKSSSGKTFKNLIQENRVLAVLDGHFHYSDMYSRLYSKKDTIFDLELNSLQNDGIIRIFAMDNDLFSFQDSSTSNKDEPIIVITNPKDSRFISQKEPLYKIKESTHIRVLIFHSSTFNPSKISSVSCEIDGKSISSNMQRVDPNKPLFVAPWNPSSYSHGKHEINVAIWDSNGNKISSQKNEFSVDKTPSFLGINLYQIVQRTNLYDFLLYWDIILIIFYLLQFGILARLIKKMIQKKQKGFETFSQKFGKKSKKMRFLHFFPYSYQSMIWKFGMIPKKKWIAILISGLLFIFGPNIAEMTQGRWGAAFFFGVGFNNSIHMYSSMLWYTMLGITGVFLPTLIFASLPVIEPPKSDNFRLRLLFHPETFVALIGTVGFMFYFSFDLWSGYYLSSVFLSFGLFWPSFICFWIIIVTIVQDYRKIDHLKTTFSIFEISNDNAQVNDPDIEMNEQNENQNQNQNENQNQKQNQNENENENEYQNQYQIQFQNQKDQKNLQYKNLLNNLDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8G8</accession>
    <name>A0A9Q0R8G8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 4b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8G8"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="160"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Spastin/Vps4 C-terminal" evidence="4">
        <location>
            <begin position="366"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="50317" checksum="D60EC439849B3C92" modified="2023-09-13" version="1">MNSKEFFYQTIQKAIELEKLKNYEEAIKLLTNVAKKLYEIIKNSTNSDEKKKENAKSILNLILQRIKQIKKIQNIQQTNQTNQTNQTNQTNNYFSNKIQRPSAQKQKIHLAIEKYLYTSPIITLDEIVGLEEVKQLMKEIIIIPLKFPQFCKRHNINNYIIFSGTYGVGKKALCSALAAEYHLSLFLVSTCSFFSQWCGEAEKILRYIFETAQDYLPALICFEEIELFCSNNYGEGESNRRLKTELLIQLENSRQFQDLFVIGTSENPWEIDQVILKRFRKQFFPLPQENDRFQMIQNLLKELNLNLKVEEIQLLAENTNDFTPLEIKDLFKKVFTIPIQKIQNSKYFKKIQQISNDNSNEPEIFYIPCEEYEEGAIKIELKDIPKDSLQLPKIQFSDFLQILKIEKKKERGKEMGKYLEWIEKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8P2</accession>
    <name>A0A9Q0R8P2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8P2"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="137" mass="16682" checksum="CC854AEFAF56E832" modified="2023-09-13" version="1">MTFKPEPWRYFVQHFEFPSISEISKRFKKNINYFFPNYFWVFITIFIFVFISNYRILIGLIIPFGLYYYFFKINKEKNIIFDAKKVLILNGLNLFNILLTSIFPNSLWIILFISFLIIIHAIFHSNSKIEIEKKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8U2</accession>
    <name>A0A9Q0R8U2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8U2"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="492"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69835" checksum="20946170F5201FB9" modified="2023-09-13" version="1">MNDCLFFGFNSFPKLFKNEPYEITKPIQFKFENENENENENEKQIKQISTGDYSIIFLFKNGKAIEYSNQNPEKIQIEENIQKVTVGYQNEAILTIEGNVFAKGNIINPNNSNEFINISSLIEDTNDRIIQDIVSGSYSIYLLTSNQNAYGIGLNEYGQLGFDFETLKKTEKPILMMKNVSKIFSGNTSNNVFLLNSNQELFVCGYNQVGQLGLGESRKETKIDKLTKIQNIPKGKIIDIQCGDNHSIMLIEDENENPKRKLYSCGYYLYNGLGEDEDENTYEFTEIKSSLFENDDNIIDFSVGFMHTLILTSNSKLIGFGENDSGQLGTEDTKNQYIPIEIELPKLRFNEEIFNYHVLCGYRNSFLYYSPFLSSFSNLEEDLIKLFERKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINLNEKIEETMKRIYLNEKENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA03</accession>
    <name>A0A9Q0RA03_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA03"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26613" checksum="FD52ECE402E34D0E" modified="2023-09-13" version="1">MSQLQNNSDENFNNEDEALPSENNLFGDEDEWIYEQKKKPISSGACCLFMYNTQQKRFWILIEALSLLLTLILLIWTIASSSSRSGGFIFFFLLLNVIIVSDNTVTICHENMEYWKSLQNIFDFIVMIFCILSMFVYFATLSSGEKTMIIICFLLRIIRDSLFIYLKFKSNPKNDPLLKRSQFNQEMIGDFDDNPFGIIDSDEENQDQEQNSNHKGDTTSTTEESNEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA24</accession>
    <name>A0A9Q0RA24_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA24"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="523" mass="60845" checksum="F3B56A5FD36760AA" modified="2023-09-13" version="1">MNDCLFFGLNKYPKLIKNEPEKIIKSIQFKFENENENEKENENEIKQISTGYFSTIFLFKNGKAIEYLNENDPNQNPEKIQIEENIQKVTVGSRNEAILTIEGNVFAKGYNINLNNPNELINISSLIEDTNDRIIKDVVSGEYSIYLLTSNQNAYGIGLNYWGQLGFDYKTLYKTEKPILMMKNVSKIFSGNSSLHVFLLNSNQELFGCGNNKYGQLGLEEPIEEEIKIQKLTKIQNIPKGKIIDIQCGEYYSIMLIEEEDENPKRKLYSCGNSGLNGLDTDTYEFTEIKSSLFENDNIRDFSVANSHTLILTSNSKLIGFGYNSYGQLGTGDTNNQLIPIQIELPKLRFNESISNYHISCGYQRSFLYYYSFSFSNLEEDLIKLFERKEFCNISFKTKNGEIIEAHKLILKYRLNQSEIEKLQEIISKKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA78</accession>
    <name>A0A9Q0RA78_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA78"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="259"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="311"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="473" mass="54476" checksum="EC4681C80A05DAFC" modified="2023-09-13" version="1">MKKINEKIKNDIWSFGNNKITKLLTKETNENIEKKQINIFPTNIPLKSISQNDFGIVFLYHNGDSIKYSIDLENELEIKIPNIEKILMIGMNHDLVLRKNGEFYLHQQYKKGKYSSLSFKIVPFIDDEKDQFVSDIVCTPDLIYLLTQKNNVYRIDLDQQFHFHFSNAQNVQKLVLLKSNVEKIFTSHHSSSGFFLDLDGKLFAFGANDFGQLGVGYCCSNQEIKEIENIPKDKIIDIQLGKEHTIILVEENLQGRKIGSVYSSGNAKYNGFGKNEDVYQFSKLDSPLLDNENIIQIGVGCFHSILLSSSGKIFGFGNNQNGQLGIPNSTLQMVPIQIELPDLLFDISYYKISCGSSNTFIYSSFSDGIDDEMIFLFKRNDENVVFATVDNQKIYVPKKMLDYRLKNKESIEKIREIISKRSYKQSIEIIEMIMYGKEEIEDLELKKEIQKMLVEESIIETISRIKILESNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAM8</accession>
    <name>A0A9Q0RAM8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAM8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="376" mass="43173" checksum="9C5460A283C245E4" modified="2023-09-13" version="1">MTYLSFLVDFFSMNINESVFGCEVKTENRTEKEHIVLFTLFDRGTSIEYTLRKVFPNELEVGSWIVSPMKKNEFKVKGYTEKEIILSIQGFSEDLVFKSQKILEIQNFKENISNQEITNQNLPNQAIQIPNLDELLFRIKNLEEKVQETTELVKNLKEFQVFNLEEKLEADLGDFISDAFTKWTLVRIQLAEKGEYEWNTPVIVPPHHRLEIIGAGYDAAKKEGFTPKILMTKCVEFKHPSDTYREPLRCGVSDFASLLIKGVTMIENHGNTKKLTQRSDKNSLFNICGNFGIIQLTFNNIIMTEKYLVNSGVFYYGRVLFGHTWISNSVTGGVTYAVSNDRGWNFQASGLVVSRSHTYIDANKVKWGTNSSILYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAT8</accession>
    <name>A0A9Q0RAT8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pq loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAT8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="213" mass="25378" checksum="5199CCE290F13B7D" modified="2023-09-13" version="1">MFPDTNFKTLMGTTNYQSFVFSFIAIFGGVMLVMLGMFLEIVEIEITGGVFMLLIICYWFVFGFVHAQTKKEVSQNKFPHYFNPIRNQNQNKNQNQNPIRNQNQNQNQNQNQNLNQNQNLNYNNFQIKDQNEPLLYQNQFQNQNQNQNQFQNQNQNQNQNLNYNYFPNQIQNQNLYQPPNLVTNQKQNQNQSIPINQENELNKENKSEDDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAV8</accession>
    <name>A0A9Q0RAV8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAV8"/>
    <dbReference type="OrthoDB" id="5986392at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="343"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="517" mass="61453" checksum="8A763181D39F16B3" modified="2023-09-13" version="1">MKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEFKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINKNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNKKLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLNQFDIFPKSFLVDIQNKVIQDKDKQNQEMKIEIEDKLKKELDKKDKEIEEKWKKEVDKMKEENDKMKEEVDKMKPIFEQHQKEIELQKSFFGLSDSEIIKDIEYVKKLKEWINDNDFFSKMKKGFSAKRDGFSSSNFHSKADNHGKTLVIIKTSSNYIFGGFTQVGYKSNVNNYINDSNAFIFTLKNPSNHQPQKFTCKLPQYAIYSNSSYGPTFGGHDIYINPNLNQGSHTNFGHSYNTPNGITPQSTQAQNYFTGNYNQWQISELECYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB34</accession>
    <name>A0A9Q0RB34_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB34"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="79" mass="9446" checksum="7D5BAF683B63D2FB" modified="2023-09-13" version="1">MKHIFTIFKYLLIKELVFSIHQEEKSIKEPFPKLFVPPFYIDISEIAQANFEKPPIEINNKTNQNQNQNQNKNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB64</accession>
    <name>A0A9Q0RB64_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB64"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="296"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="485" mass="57395" checksum="7619C340FB52C42F" modified="2023-09-13" version="1">MENYLNLEKLSNDLKNLFQNQNQKEKEEESYFDFEIICEQNQISFKTHKSILSSRSQYFKSLFNSKMKEFQENKLILKDVSTSILFPILNYFYSGKIEINLENVIEILIFSSKYLIDELIEISLKFIKNNLQIETIIDILKLSELMNFNQLLDSSYKFISDNFKEFIKTSFFLELEENHLNSILLSNDIPINEFELFESVIKWGKHKSDINQEKLDREEKEKLQNQISNLIDKIRFIDFSKQELKDILKEDLIPNQISQKLIQFQKLQNQEKELNQFVEKENSLIFKSRIRLDSEIIKEKEYIEKLKEWINDDEFFYKMKLGFSAKIDGFDCKNWHDKCDNKGKTLVIIKTEDNFIFGGFTRVGFIRDKSKWNNDYGDVGWITDPNAFIFSLRNDKNDRKSEKFPIKKSQEQYAILYGYSGSGPTFGFGNQGDIYLNSKLQPGLSNFGYVYKLPNGIEYNTNEAKSYLAGSFKSWVVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBI1</accession>
    <name>A0A9Q0RBI1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High mobility group protein dsp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBI1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="164"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="164"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="265" mass="30919" checksum="2872D46E13E4ACAA" modified="2023-09-13" version="1">MNSEEEKQKQTKESKEQKEPKQTTKAVENEAMPQRPKYPQNAFFMFAQEMRPHLISVHKGITVSELGKLIGKAWSKCDPDKKQIYKNLAETEKQIYQQKLQEYHKKMEEYNEAHPDLSESLSSSPTSSPIEKGVRTRSKSKKFPEEVEKKNSKPRVSPLDPNKPRKPPTGYLLFAHHIRPQIKQLNPKMKITELGKLTGEKWRILSDEEKKTFLDQAEELKQKYLIELELYQKKKQEEEPKKNGNSSDSNHSSTENDSEHDTNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBP3</accession>
    <name>A0A9Q0RBP3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gtp-binding protein rit2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBP3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="195" mass="23111" checksum="348AD204FCCCE902" modified="2023-09-13" version="1">MNPIKILIIGNGGVGKKSVIEQFCYSQFIQYYDRGIEDSYRKQVVIDNEILIIEFANYMDYWGDLDYMKQRIYQEPHGFIVVYSINDKYSFNELENYLNEIYKYREVEEFPIIIIGNKNDLEDQRVITKEEGEEFANKYFCPFFETSAKTRSNVEETVFTLLREIRKYPFDLNLNSNSNSNSNSKSNSKSNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBP7</accession>
    <name>A0A9Q0RBP7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBP7"/>
    <dbReference type="OMA" id="MYAVYNQ"/>
    <dbReference type="OrthoDB" id="3065869at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="639"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="707"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="956"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1055" mass="122061" checksum="BB489EDCF8C8E18F" modified="2023-09-13" version="1">MDIWEAISQNNIEFIKNIQKIPENELEKESKPILHFAIEKKSSCEIIRNLLEKGAELNSKNKLNQTALHLAIIHKSEIEVIELLIEKGIGIGNFDKKNKTPLYYAISTLRENRLEIIKILLKNQININSVSSSYKNPLQTACKQRDSIEIVKFLVENGADINATTVMNETALHIACKQRDSIEIVKFLVENGADINAETIYLFSDERKTPFHFACEYNTIQVIDFLIENGADIHATTDEKKNGLHFACEKNTVEVITFLIEKGLNIYSKETRKESNLHLACKSNSFDVVKFLFEKYPDNDMKSDQDITPLHYACLNRKDAPKIVKFLIENGADVNAKMKENQTPLHFAFQPRRDPFGVVKCLVENGADVNAKTIRNETPLHFAFRYDTSFEVVKCLVENGADINAKTKADKTPLHLICEKSDYSLEIIKFLVENGADINAKTFLNRTHNSIEIVEYFIEKGVSINEITHNHETAFHFACEQNSIEIVKLLFEKGANIHLRTNQNETALHLSCKKQNSLEIVRFLVEKGVNLHLLNKYKETALHTACRYQNSLELIEFLVENGVDINAKTSRQETALYLICNQENSFESVKYLIEKGADINAKTEKNKSPLHVACRQRNSTDTIKYLIENGAYINANTLLNKTPLHIACKYKHTMDAIKLLVEKGSYINAKTYQNKTPLHIACEYQESLELIKFLVENGVDINEKTAQQETALHLASKKFKSYEIIEYLIEKGIDINSKTKEDKTTLDFAIINHNENIQRLLLMNDANVFELKFRQATKQFIETFSIIYSINEDFLNLFQSTDNFSNWKIECNDSSNFFVHNLILSLRLDNSDSTVQKFINLCYQKPRKDVELALNFIYTGFPNLQKITKKLLKQLNFTSNILINPQHNPNKQTQLQLMKLQEQEDCEKEKEISKEFEMTEEFFKEIGLNSNWMKQKKGKKGILKDLHKLYQQESTKDFTIICEEKEIKVHKLILLTRSDLFKGMFQLNVSDKSNQVHDYSGKCFETLNQMVYFFYHDNFNQSQEINKEMIKEFEDVKDYFQLNQNSMLDLLLRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC13</accession>
    <name>A0A9Q0RC13_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small gtp binding protein rab8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC13"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="319"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="436" mass="51417" checksum="5A36A8656156548B" modified="2023-09-13" version="1">MKQQNKKDYDLLLKIILEGDSGTQKNKIIQKFMQEIVTQSNDRWIDLGPLCKVIEIQGKTVLLQINNINKYGGYKSAYKSFYSKAYGAMIVYDITNKKSFENVEKIWKYRIRMHAKENIQMMLIGSKCDLENERKISKKSGKKLADKLGIPFYEVSVKENINIEDAFTELTMNILDNLDENNQLKPKPKSKPIIYSIQEDMKQLFERKELCDFEIECKDDQNPLSKFKIPVHKLIIQNRLRIDENQLENQFYSILSRDSKQNVDVLLKWIYFGKVLLSNLSIFEEWKKKLSNISKVKIKIGINPLLDDLKRLMNEEETKDFQIISNNQKIKIHKIILIARSELFRGMFISVTEDKSNSVHEYSNKKTKTIQNLINFFYTDEIPKIKNKTILKELKECVDYFQLNSKRLNQLIKKIIGEIPQQQQQQQNSKKKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCS5</accession>
    <name>A0A9Q0RCS5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5074009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCS5"/>
    <dbReference type="OMA" id="ELHYPAY"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="503" mass="60758" checksum="9721623D1899F693" modified="2023-09-13" version="1">MLNNLNLNQNLKLLNNKEKESKEELIIKRIWITILQEYEIPCYEFFLKDKFQNSKFPFSFYIYSLIEDFGFISKDMKVLNELINLPFYECSLFKEINQIQIQIENENQNQNQNQNQNQNQNQIENQNQNQIENQNQNQNQNQNQNQNQNQNQNQNQIEIENQNQNQIENENQIQNQNQNQNQNQNQNQNQIEIENQNENENEIQIQNQIQNQNKIEIENQNQNQNQNQNKIENEIEIQNQNQNQNEIEIENQIENQIENQIENENQNQIEIENQIENQIKIQIENQIENQIENQIEIKIEIENQIEIENQIEIENILSRYLNDFLIFAIGKTNLEKFNQIQINLINLIELFNDKKIIRLSLKEIHSTFFQYIKSLLDNIFLIQHYFNSLAILKTLKTSQELKKKTFSIFSFLENYFSSLRNILFNEKDNRLKKFVCGIISKSNFEIQNILLSLIKNCKNKNNEKTKKKTKELIENWRSEVIKQLEHRRKVNQTLIRGYCTLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCV9</accession>
    <name>A0A9Q0RCV9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ran-binding protein 9/10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_07107</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAP2/GCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10691598at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040326">
        <property type="entry name" value="HAP2/GCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764:SF0">
        <property type="entry name" value="GENERATIVE CELL SPECIFIC-1_HAP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764">
        <property type="entry name" value="PROTEIN HAPLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0278">Fertilization</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="14">
        <location>
            <begin position="1101"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="508"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="936"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="778"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="522"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="948"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5075537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1593" mass="185795" checksum="0AF03DD09845B384" modified="2023-09-13" version="1">MTEVSSVLSVNLNIMSYVTFIAVAFAAIFQFIYLIFRMSQRHPKLLALSFLALGWYYCYSMISLVVNFKPNGKLETAMRGSFVFAAVLMGSGPFLLLTPIKTVVSNIQNIVKQQEIGSSKNQINPLKFLFFFLCLIGSFFTEYSLIRTLFSILDLDIRFAIGIVVGFALLASVFLLAFFSVLIEQEIVIKGVNMMESLRRSIIIKRKNIMNSRVYAWFYIILFICAIVGVGVLIGIVIKNENDLINDKDSSKKPTESLSYMFFIWNSLVTVWIAFLIFGVFIHPIKIELVETDIGLVSLSDIRYFAVARSFDRTILLTFSKAPNDYSKNEIESQIKYLVKKSSIEDGYTNKINFSDGEIFQLNDHKCMFFLAVQFYYQEDLAFLFLKKMKKYVGNKYYHEFANPLNGEFEEINSGFYLYSYDSWSEESKPFINLMVQTFGNEDCRYLLLEEAKRIKKMEQESQNWNSNEIQKENISRTLSTIKYLNDEIGTLLLDRLLFEESQSQSEIDIDSEKKKKKKKKENKENKESESKENENKENENKESENKENEKKEKENKENENKENENKENEKNSNQFISIKEMIKNDINSYYKLIKEKKIYLSYRKYPEVENPIFFIQGRNSGYDLPIPKFEVMTEEEMKKTQHPFKIQTKKKFLKLHSKQQWIQKDISELLHLDSPETKSEAKRKLWTNDSYLFNSEYSLDRFNTQKEKSKFVKREFTEMFPVKDSKLAGDVKMVKSFVEKIEDEMDLGKGNVFKMKKKADGLEISDDRLTIKSTNIKNDLNQNRNQNEIENQNQIENQIENQNQIENQNENQNQIENQLQNLLPFFIRNYQDIFSTFNGKCLIYYGEKNEYPDGLKVIMEKPIPLWNQFYLQNFESFYFEIKIANTGKINKANIGIGLYDESQETSTFEELLQKNICIIADEELYFQQNPQAYKKKKKDEKDEKDEKDEKDIKKDDKEIEPPNPNLRADPLKLTIDSDSDSDWDIQPQKPKMNLGNNVKILKPIKLGRCLGCLISIKTQKIIFYVNSQIVFSVPLNFSQDQMKKIFPMIWFKTESTLAIYKMGFGDYHSGPKTSTDLMFEHLLDENIEIDENENENENNNNNNNNNNLQLISLNQPNIKQNEKLIFSLPSEIIIQEKLNLKVNEYWRKKNRSHFNSNYSNIVSNLPFIEGICMFEVKIIKSKIPVEKFSFGIGLVIKSEYEKYHKEYSSCCLGKIFEDEEKTQKSLIPNSSSIGYYGNTGMIFKNNRSYVYGPQFYEGDTISCFINLSTGVIAFAKNGFFLGIANKFEPNQVVLPIISFGTEGITVKVNFGAKMRNFEPQNRLEFIDPKSGFEYPNAFGKDTIIPFVDNDIFDVVSQHTQKYFECLTYITPFTILEQKKGMIEIAKLIKRLKLIMIKQFISDESLSKNEQLEVDLHVRLSLNEIRKTFVLKEGEFLYNFSQRKKLIIDPCCLNFEFDPKLQSKVEIRIIHIILICINSFRWLRFIEGFRAAEFLESNIYSLDLEKKAINSLGKSSGLTKEQFEELNLFIDSSLDYFMKILELLNSHSISSQAISHIVAKSNPLSQDETEDMAQEYVRDDGGFQDPFASFKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE48</accession>
    <name>A0A9Q0RE48_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE48"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="115" mass="13687" checksum="2898D8E9565DEC18" modified="2023-09-13" version="1">MGTYSYKQNFISIKTKEKKIAKENYQKKYQNPNFDPHFYGYVDNQYFPFQPRDSKKYLLNEVILGINGIILLSTLIILNYFIDSKKSISIPKLFLLSEINLIITIFWVIYLKPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REJ7</accession>
    <name>A0A9Q0REJ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolar gtp-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_00070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REJ7"/>
    <dbReference type="OMA" id="EWKNDVM"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1190:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="169"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5076753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="705" mass="82447" checksum="1FE4C52C1A5F444C" modified="2023-09-13" version="1">MVKYNFKKIRTVPDSSQFIDIVLSKTQKKTPTVIHKGYAITRIKEFYMRKVKFVQQTFHERLSMIIDDFPVLDDIHPFYGDLMNILYHRDHYKLALGQLNTARTLIDNLSKEYTRMLKFGDSLYRCKQLKRAAVGRMCTLIRKHNSALNYLEQVRQHLSRLPVIDPTSRTLLVCGYPNVGKSSFMNKITRANVDVQPYPFTTKSLFVGHFDYNYLRWQAIDTPGILDHPLEERNTIEMQSITAMAHLKASILFFIDISEHCGFTIKDQIALFKSIKTLFTGKPLIIVLSKIDLLKPNELKEKDRKLIESLIIDENQNQNTNENENENEDEIKMDVKVIWESESGILYDGDQIKIVCMSSLTETGITLVKSVSCDLLMAQRIETKTKMKKMTEVANRLHVSFPKQRDNKQRPPQIPESVLNARQNPTDDEDKPKKILERDLEKMFGGAGLYNVDLNKYFILENEDWRYDVVPEIIDGKNISDFVDPDILKRLDELEIEEEEIIRRLQEEPEEQEGLTEEQEILLSKIREKRTIMHNDSKIRRRRHRKRIPRNLKPEKTVEQFESHLQNLGIENAPLKEAKKQAKKQTRGRTKIRKYFDEEPTQTEEKEETQNKRERSLSQTRSKLKVNRKSRPRSKSLIRSTSVTDPKTQGVKSVNELLKVEKLSWNVQKIPNKLGKKGYADHAIYDTKPKHLFSGKRSSGKTDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RER7</accession>
    <name>A0A9Q0RER7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Developmentally-regulated gtp-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RER7"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="289"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="367" mass="41385" checksum="DFE0D3CDCACFA9DC" modified="2023-09-13" version="1">MSIPEKITEIESEIARTQKNKATARHIGLLKAKLAKLRRELLTPRGGGGRTGEGFDVSKTGDSRIGLVGFPSVGKSTLLNKLTTSHSEVAAYDFTTLTTVPGIIYYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNMLLIVLDAMKPFAIKRKIEYELEGFGIKLNRDPPNIKFETKDRGGVNFVSTFPQEFLDQEIAQSICAEYKIHNAEIIVKYPDATPDDLIDIIEGNRIYIPAIYIFNKIDQITIQELEVLSKIPHSVFISAHFEWNLDELLLRIWEYLDFIRVYTKPRGQIPDFSAPIIMPSKSRSIESLCNRIHRNLIHDFKFAYVWGSSVKHNPQKVGKDHLLDDEDVVQIVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REX6</accession>
    <name>A0A9Q0REX6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REX6"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF104">
        <property type="entry name" value="PROTEIN SPRINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="163"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="307" mass="36397" checksum="BC354AB5C156F63D" modified="2023-09-13" version="1">MKKKKKNEKENEKEKEKEKENKNNQNVKSNQITEMEILLPCSIKLSNLEGIESTEIYYEILVIQTIYSLLKNLQIHIFLKNYNWKQDFKIKKNETKILRKQLDYMKTFTIKQINEKLKAENEAISLSPEEKRRINFLIEMNFEKICFPPFLQNIMKSIISKTQKEDLKVNQNKEKLKTKTMEFYGIANNLRDLDWSLPIKSLQRFTNCAYPFEFLNVIINSALGIYQTIERQLPNQQECIPQQLISGDDFLSIFIFSLVQSNFQKLKAVENFILSYCDPVEFSSESGYYLTTFCSAVQFIEKFNEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF86</accession>
    <name>A0A9Q0RF86_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF86"/>
    <dbReference type="OrthoDB" id="10650961at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="45410" checksum="2FDC2CBA9A57E667" modified="2023-09-13" version="1">MKRKVCRIICCLNFCFFFLPAIIWLGIDQSVRTSLVKTDCEIIDKYYIEYSYKFPESLPIVSPDTTPQYRATRPTQLTQQTQQTSLENLFASSCYTHATTNYVPFFRLVYNADGTSYNETSCNFGKVCWTRKGSSCSVSNCDTSISTSSCKNFANLKKSSIYEKYDIGSADCWYSKKQNDYATVHYPMPNYAWCLFFWIPFIILKNVVQKSGNGYQRENFFLDNNNNNNYNQLQNQRNEDYHLNQKQNNPNLNERLLDNETIVDPPPPKPTANDDLKSIMELYRNNHETNQKHKDPNQNQNQNQNQNQNSSGNQKFQRYQNLFQNDGYNYYKYQNDFANQTNEMQMNVFQPQNSQLNPFPPFTQTNQAGPIYNPNTENYNIQENKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFE1</accession>
    <name>A0A9Q0RFE1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFE1"/>
    <dbReference type="OMA" id="TVHTKKI"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="42"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="489"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5078776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="617" mass="69746" checksum="B3FB812DD2D67DB4" modified="2023-09-13" version="1">MAKKYLTWFKNYQKIQSGNFEKGNIEWFIGGKLNACFNCVDRHLPKKANQIALIYEQEEPDQTEKITYQEMKEKVCQTANLLKSLGVKKGDPVAIYMPTCPAAIYTMLACTRIGAIHNVVFGGFSANALRERLIDCKTRIIFTSNHSIRKGRRIFLKKMVDEAIKDLDFIDHVVVHKLTESEEDFHEEKDKWYEESIAKESKECLIEEMDSESPLFMLYTSGSTGQPKGIIHTTGGYLVYAGMTFDYIFDYRENDIHCCVANIGWITGHTYTVYGPLLLGATTVLYEAVPIYPTVERYWQSIDKLKITSFYTSPTAIRLLMTFSDQNVIKYDLSSLRVIGSVGEPINPEAWLWYYKLVGRERCTLVDTYWQTETGGVVLTPLPGVTPLKPGSTTLPFFGISPVILDPSTGNVLTENNVTGLLAISSSWPSIARTIYSNHKQYLNVYFNQYKGFYLTGDSAFRDSDGYYWVLGRIDDVITVSGHRIGSMEIESALVSHSHCVEAAVVGIPHEIRGQAICAFCVLKDDPKKEEQKKDLDSLRISLSNQVATQISRIAFPDQIVFVNALPKTRSGKIMRRILRSILIGKTSQQDFGDTSTLLDPSVIDELIEQVKLQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFR6</accession>
    <name>A0A9Q0RFR6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFR6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="423" mass="50095" checksum="4AD5D1E36E86B084" modified="2023-09-13" version="1">MLEKNLSQSQLKDKLQSLSIPQYHEFLESGKEENSLKKHSILRVDFLIDFKILPRFKKKLNYQDKILLAYEAAVVLMHKPTISSETLYLICRNYEILKTFTINERKTKRNEKFFNQIFQIESKLETSGEDLVQTLETRLENFPGFCWLIQTEGIYKKNSKKEQKCLLLYIPHSNPIKNEKKVVLFHPDGVIHTNSGPSFSIFDTNSTLQNLKRELSSYTLLSLTVLSFKIQKSFREEIPKENLKDNEKEKGKMKEKMKEKMKEEKEKEKEKEKEKEKEKEKEKEKKKDKKRKKESDSTDSDDDSDDDSSDSSEKSSDSSENQVKNQVIQLMMILMMMIQVIQLILMMILMMIQVIQLIQLILMMILMMIQVIQVILMMIQVIQVIQVIQVMKIKKKLQRKNSKLQKRKRKLMIQKLQNLQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGL2</accession>
    <name>A0A9Q0RGL2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="924"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1500"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1608" mass="189218" checksum="389422D595E0C5A4" modified="2023-09-13" version="1">MARIPNTSEIQFPKAISRTITTKTENEQKQPQKTVMNSVKFPKPRPFSQMINTNLNEQIEETNTSKNISFPKPKQKPWSIQVDIDEQENTQYPKSPRQTPLNNNNNINNNINTNNPNMFEKQRFFNRTNDDESKFGNGKNQNLKISEKFGNGKNHNLKISENSPNKNPFHKSPPKFSALKKSPQSEKQQNHSPNSNISGSPFTKNTKTRTEFGVNQKSPKNQELQEPFNVPKRLNHMQNKIKTGAKFLASGRRFSLFEQNRLSNQQNNQINNSRLTKTTNRQNQDQRIARNNPYVIEQQQSNEIKSNISTANPAIQFPKPRKMQQQAEYNPYVSSKPIATARIWSHFNESLEDSEKVSKNRSVVKRPPRPDKLQHSDYKSNVRQKASIFVQKSIHNHPQRPLPKVISRRQSKVLLSPETENIDSENQQNAQNLDRNSIFQKKIFIKNQTQLQKIPKLHSPDPNQKPALPPKHKIARSPPDTLQNHRQFSHSPKFNHHQQKSPNYETDSFHNKNYFAESVHQNRLSLFEDLPTKKHQNHGNKTFQESLKSPRRFVPNKRTNEVQFPKRFSPKKKSPFAVNENSNIDSNQQSIHNEFPIRQKSPPPLPVRKDSLGVNNELQRTQSEENEIEKIQFPHKFPNNRKSPVQQSHSQNEPQPRNPEKSTQSFTHVYKQIPDKLRKIVEMNQNTNQNTNQNMNQNINQNINQNTNQNINQNINQNINQNTNQNINQNINQNTNQNIKKLINNEKVQFPSFKNRDNFSKRTFSQKSQIENAFNDVIAHKTIQSRKSSTHIKEDEQNNLENYYFDNSKQKQYPKEEKKEQPNLTKTVKTITGKTFQNQIEDTRTQYLGKKKTDDEYNQYIGDDEQNESMNYTVESVAGNTMRKQMIESNPNSGKGDYDSEENSEFDLFTSELENREPHDDPPKRKRCFEYLFKMENTFFADLNDFLLTFYIPINECQLIDHEQIKMLFSNLEQMIAHQENIINKLKEMYTHKITEIEISSIYETFQDSIFKEWIQNYEASLYGMHRLRRNISEFDKVVIECESRTSEEMDFFDYIIKPLKYISSLFTVLREILFNISPTSRDYEKLYVLFDSTEILLLSASAYIYKYDHQFELEEIQARMTGLGDFEIAHPGRYLYQRGQVDRITNSSKYTVKYFLFNDIMILARRKGWKENLKTEAQIYYESMSIRDLDNDPKGVIINAIEIVDVSRVPRYILSCEKAETKQMLWKELTESLYVRVHGPMFEFSEQQIAENRQLLSVQSTKIQTTRLEDVPKAAQTDMQKRANVIQELFMTEQEYVRDLHTIVNHFLLPLAEKGIIHKQDMQPIFSNIREILQVNEDLFSTLKLNLEQNGGDYANLDVGRVFSQKADYLKFYSVYCLANKTALELIKTKYKKKEPFSDYIRYCRESIPDCRQLDLVDFLIKPVQRICKYPLLFREILKTTSSNSPDYVNLANAYNRIEEVAGFINKTKKSADGNARVNEIMEKFTNRKKFTYLSSTRKFIHEGSLYRFEKRHYLSHLWIFNDVLLIGKPKRKDRYLLKAFVYFAKAFIREFEVENEYLFQIIPYHSRTEYTFACQTEEERIEWTRLIKAQIEQLAKLGQIPSDMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGS1</accession>
    <name>A0A9Q0RGS1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ada2a-containing complex component 3 isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGS1"/>
    <dbReference type="OMA" id="LEMIEVF"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="502" mass="57083" checksum="68E38D9206288754" modified="2023-09-13" version="1">MNICEIIEKNNIESLKKINFLQEKDLKINNKTPILHFAIEKKATEEMIELLISKGANPNLVDKKGRNSLHIAVKKNSNIGSIEKIISKGIDINSKTNRNETALHFACEKYSLDVIKFLIEKGIDINSITIYHETALHIACENGLSLDVIKFLIEKGIDINAKTDINQTALHFACEKYSIEVIKFLIEKGIDINSKTNQNETILHYAWVDINIKNDNDETILHYIFHINSMELLEYLIKKGINIYAKAKDQKTALHIACWEYSSLGIIEYLVDKGLDINAKTEFNEIPLHFACENNSLEVIQYLIEKGCDINAKTIQNETPLYFACLNNSNALEITKYLISKGSDINAQTKQNSTALHFAFQKNLLNIAQYLIDNGIDVNAKTNHNQTALHFACQRNSFEIVKNLISKGSDVNAKTSYKETALHFACYQNSFEIVEYLVEKGADINVKKAKNETPLSISIQKGNEKIIIFLLMNDANIFDLKKKQITNQFLILFLKFIQSTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH14</accession>
    <name>A0A9Q0RH14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein o-mannosyl-transferase 1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_04095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH14"/>
    <dbReference type="OrthoDB" id="10260377at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="ArnT-like N-terminal" evidence="11">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Protein O-mannosyl-transferase C-terminal four TM" evidence="12">
        <location>
            <begin position="320"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Protein O-mannosyl-transferase C-terminal four TM" evidence="12">
        <location>
            <begin position="587"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="416"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="416"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5079782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="687" mass="80600" checksum="94C5409E1ABECF3A" modified="2023-09-13" version="1">MNQKSKKTSQTKIKPTIKIDIINLLIITIASFLTRFWRLSEPPSVVFDEYHFGKFTNWYLLGEYFFDIHPPSTKLVLAAITRLTDYKPTNFYDHIGFPYENHKYMVLRFQQAFIGSLIPPVLYLIIRQTTSSTTPALIAALMGLFDNTLLVESRLILTDGFLFFFISITILFTITFRKYPLFSGKWFFFLIVAGFALSLSITTKLTSLGGFAAAGVLQILYYISRYFTSRPKNGEFWNISFRTPNTLSETNTLLLDLLTTGLSLLGIPIVVFFVSWIFHFFVLPYHGMGDPYMEPNFLPCVASPNDVFQPHPLLCTPLLSRILNLNKIMHNANMGILAPHAYGSGWKDWPLHTGTIANYWAEFVDDTSKYVFCLGNPIVWWLAFAGVCFGFLLILLVVLHYLWLFFRGKITETNNENENENQNQNQNQNQNQNENQKNNQNQNQNQNQKNNENENENQNQNQNQNQNQNENQKNNQNQNQNQNQKNNENENENQKNNENQNQKNNQNQNENQNQNQNQNQNQNKNKKNNENQNQNQNQKNNENQNKNKNQNQNKKIKRLKKSNTKITKMQKIKNFFHSFFKKSYNEFIILLYFFAGYTASLLPFILVPRVTFIYHYIPSLIFAILLTSKMFDILFKLIPNNFFKMFILSILIGSIFFGWWFFIPFVYNIPFKSDYFPKFMWLDSWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHW6</accession>
    <name>A0A9Q0RHW6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000034">
        <property type="protein sequence ID" value="KAJ5079184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHW6"/>
    <dbReference type="OrthoDB" id="101918at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="215"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="569"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="647" mass="76346" checksum="17E059265CC312EA" modified="2023-09-13" version="1">MINNIPFQNLQVNKQKGLFFNGYSYPILTVIEILICFAEFCVNDLILNIPRPSFREMEDQFKKGKTFLNRLYNLFVSKLFQISQELIHITEVTLPEIIVEAIFQTTEEYWTKKYISNSQNHSQKKIKENHQAFIQNQIENTPEIFLKELKSKLANTFDLDVSLSTIYKHLSNEMGFTKKKMNLRAPRKYEPENMEYYQMFYLLMQNIFAHYPLDRVFFLDETGVNLHNAYRTTGWSSKGKKIIAPFFNRNQKYRINSICTFSILGFISLDSHKSTINQWLFWEYIRDVLFAQLPPSSVLVMDNCAIHHAIDYEMKTIFATKDIMLVYLPAYSPELNPIEMAFGVIKKMLKNHTEEFISNPFNTWHKLFSEFNENQNCLNFFLEDYPFLKDPNFKYTLSENLNNNFNNNFNFHFNDNLNDNLNDNLNDNLNDNLNDNLNDNLNDNLNDNLNDNFNNLNINLNNNLNNFNDNLSNNLNNNLNNNFNDNLNDNFNDNLNDNLNDNFNDNLNNNLNNNFNDNFNDNFNNNFNNNFNNNLNNNLNNNLNNNLNNNLNNNLNNNLNNNLNNNLNNNLNNNLNNNLNNNLNNLNDNFNDNFNDNFNDNFNDNFNNNLNNNLNDNLNNFNNNLNNNLNNNFNDNLNNNFNDNFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RJ62</accession>
    <name>A0A9Q0RJ62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RJ62"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5080504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="378" mass="43514" checksum="99D08A14CDC339C2" modified="2023-09-13" version="1">MFDEDEIQAIVLDNGSFEIRTGFAGDDAPRTVTSSVIGEKLNQYDNYSTSSKTEYIGNEAQKNREILNLNYPIQRGIVEDWDNMEKMWDNIFANQIKINPNQHPILMINPPFNPKSHREKTIQIMFETFDIPAFYIANSGVLSLYSSGRTTGIVVDIGHGVTLTQTIYEGYEIPKGIDRYDISGFDLTNFLIKLLEERGYSFTTSNEIEMAREIKEKLCYCSINYEEEIKQNQNQFNLEKEYELKNGDIISVSEERIKCCEGLFQPRLMGIDLEGIHKIIYNSIMESDIDARRDFIGNIVLSGGSTFFPKFSDRLENELKALFPQQTRVKLVAPPERKYSPWIGGSILASLSTFQRMWISKEEYDEVGPNIIDQKCYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4Z8</accession>
    <name>A0A9Q0L4Z8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sorting nexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_13716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4Z8"/>
    <dbReference type="OMA" id="PNHINDV"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000023">
        <property type="entry name" value="EH domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF46">
        <property type="entry name" value="EPS15 HOMOLOGY DOMAIN CONTAINING PROTEIN-BINDING PROTEIN 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="77"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="456"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="819"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="568"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="826"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5066337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="874" mass="102441" checksum="0EB1B12079DA1E25" modified="2023-09-13" version="1">MSVKSDLLISFEDDIDTSKQNQSNKPSKSQGVQNKQISLLDGDFSPQINKSNQKKSNNFVEKQQPKQMNQISKPKKLTGKDAILFWCKQMTQGYKNVNVKDFTSSWRDGLAFCALIHRHDPSLFDFDKLDPNDKIGNLNLAFDLAEEHFGIARLLDAEDLVLMNPERLSMITYLSECYRELSNFQAKQPTEKQGLESKIKEGIQKGDIYSKSKEIEKKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSESESESEKESKKEPKKEPIPKQTEELHSVSLEENDEHDSSKKTKPKKRRIKKIRRKKKTETTEKEGEQKKHKKGQKKEENMKMDTENEKQQNQTKNKNKNENEKKSTEKQKETKETKETEKAKKQETETKQKKKKSFLHFGRKNKKEKEDKKTKEKNSKKKEEPKKSKENKEEEKETQNKKKELLQSFLNEPKKNTENKGPYFDISVSKPTKVGKGRNQHTEYSISFRTTSTGTSETIKRRYKDFDWLQQSLVEEIPDFIIPSAPTKQVRNRFKDEFVEYRRRALERFLNRIANHDVLCQTRSFRLFFQIESSEVLQKQKKNKKKSMQEKNTELEDSLTIYLNEHTESDAEYINQKRKELSNLEKSTEKLTKIMSDLIAIKSSLSDVYKNFPNHINDVVGKFQTDSPQPFWKALNQTFGEISEIFQEKANQETITIEEPIKEYSTQIHGCKPSYQHYEKIFTQYLKTNKDYESKKTKYQKLAGQGSKEQKAQDDLIKTEKNLEEIRNSYSKSSAILTNEIKVFEENITQDFSNLLMDYAMSQHAFQRNVVSLWEKFMQTFDEKDDKENQNENENQNQNQNQNQNQNENQNQNQNQNQNQNQNQNEIDNDNNQNKDTDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5E0</accession>
    <name>A0A9Q0L5E0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_03388</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5E0"/>
    <dbReference type="OMA" id="YMDFPPL"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="16">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="115"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="387"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5066055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="492" mass="56458" checksum="617D74B17EC5D000" modified="2023-09-13" version="1">MSQKKEKKRFAKFRKKKKDIVISRPYNVTHDIHVDFNSETGFTGLPKQWESLLKTSGITKEEVHQNPDAVLDILEFQNKPTMKGQQKQEAQPTNTTNVQRKLDTLISKEDPNQLFTGLTKIGEGSTGSVYVATHKATGKQVALKIMGEFIQQNMKVVENEIAMMRSSKHKNVVEYIGSYLTGDSLWVAMEYMDGGSLTEIVSICKMSEPQIAAVCKEILRALNYIHGLNRIHRDIKSDNVLLSTKGEVKLADFGYCAQLTEEVTKRNSVVGTPYWMAPELIRGQDYGVKVDIWSLGILMVEMAEGEPPYLDYPPLRALFLIATHGPPDLKEPNAWSSEFKDFMAKCLEKEVNSRATADQLLRHPFIRKACSLRGLIPNNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKEIIKEIKIGIDYFQLNQTNPNLLDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5E9</accession>
    <name>A0A9Q0L5E9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_13406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5E9"/>
    <dbReference type="OMA" id="PEATVNW"/>
    <dbReference type="OrthoDB" id="419508at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040543450" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="554" mass="65140" checksum="0669A8B763B73B4E" modified="2023-09-13" version="1">MKIILILILFLYYLQTIKSIKQWGSVSIIDEEYNFTYENIKNTSADSWGYIEINEETGWKTLEIWVNPNISPIEGKRGSYAAGVLEAGLTQKYIYELWINIKQMWFPQPNSTISPLVVKFLSTQDTWTRGNIQEFEATDDYWRNVGYVLYQSDGILNGYNYFVNNESEKMEDWMLQVLLYMPDMMDLSIACGLDNHEDFSNDFFTDSKFEYNNIKFEDLFNSHCSALVKFLKDSNEIYFAHTTWYIYIAEIRFMKNYHIKFNGDTSIYSDSVVMSSYPGTICSADDYYLTSYGLGILETSFSIFNQTLYKKVTPYSLLSWMRGVLANRMAYDGVSWAEFYLKSFSGTQNNQWVILDFNKFDLFKKSKLNDLIDGTLYIVETEPGYFYYQDVTEFLRNYSYWPSYNIPFSKKIYNETGYEARKEKYGPEQYSYENCSRADIFRRNQTMIKTIEDMKEMMRYNDYLNDPLSHGDPSLAIASRADITENFPTGAVDSKVTSFQLFQNQMSSWIINSPTYVDLPPFTFDNPVFSSWIHLDIPDTIKFPWVLFQFNDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6C7</accession>
    <name>A0A9Q0L6C7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_13496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000140">
        <property type="protein sequence ID" value="KAJ5066559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6C7"/>
    <dbReference type="OMA" id="WSADLED"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="96"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5066559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="265" mass="30674" checksum="433898E196DEE990" modified="2023-09-13" version="1">MCDEEDCEGCPSWILDILYWLPPIILILLVVLTYYPLVETDKLITQHHYLTGTILNILYHFFLFMYLITLILSVLTNPGDSRKITKSIDIENGIIGEKRFCKVCNIYKPNRAHHCSICKRCVLKMDHHCPWISNCVGFFNYKYFILFLIYSFLISATAATIVIISFFMPQNDEISPLIIIGSVIAMIIGFSFVITLIPFIAYHLALLAENMTTIEDSKTKKDNEKHIWDLGLKNNLKQVLGENYLLWFLPTYISVKGDGFNFEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L754</accession>
    <name>A0A9Q0L754_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L754"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="323"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="491"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="69302" checksum="D349CC6504735DAC" modified="2023-09-13" version="1">MNEIIFFGLNKYPKLFKNKPNRIKKPIQFKFENENENENENENENEKQIKQISSGYFSTIFLFKNGKAIEYLNQKYLNQNPSEIQIEENIQKVTVGYQNEVILTIEGNVFAKGENINPNNPNQFINISSLIEDTNDRIIQDIVSAYNSIYLLTSNQNAYGIGSNEYCQIGFDSKTLPKTEKPILMMKNVSKIFSGNTSDCIFLLNSNQELFGCGDNGYGQLGLGESRKEEKKIQKLTKIQNIPKGKIIDIQCGGFDSIMLIEDENQNPKRKLYSCGNSVFNGLGKYEDIYEFTEIKSSLFENDDNILDFSVGNTHTLILTSNSKLIVFGDNSYGQLGTGNTKTQYIPIQIKLPKLRFNENISNYHISCGYYKSFLYYSPPSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELNNKSFQIFEYWIYSNQIKKEIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L811</accession>
    <name>A0A9Q0L811_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proline-serine-threonine phosphatase interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_03087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L811"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="8">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5066743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="402" mass="46999" checksum="A26A78FBD48BB938" modified="2023-09-13" version="1">MEESKESKEMNILFSNNFRGFFENPQQGFDIVIEHLEKQSQSSEEIVNFLNERLKIETDYAKQLEKLSKITISNNEKPQFLSGFEALSRELQEVSNTHLQFVNLLKNDIIYPIENLKTMQKKVRKKVISDFRKMTKELTISIQKVAKAQQKYEKIGSEIRKLDTSLSEIEKESKKQSIELKIENLKIEHLNAAGEYKSEIIEYNAMKNKYDAMLTEKLDFFQHQLMERNRGIKAAFVCYTKIYQDLVNKKKESNQKFQDICQSIDPKKDFALFVDKEKTSTKRFENEFFQDIKVTIQKNQESLKRTTSLGFQSKAFSPSSPRKFSIRSQTETNEKSNIQQLTPPTPPTPPTLSTLSTLSTENSNPNPISNSNSNSKFKFKFKFKFKFKFEIKFKFKSKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L847</accession>
    <name>A0A9Q0L847_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L847"/>
    <dbReference type="OMA" id="QRGAGYT"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="251" mass="28853" checksum="0A12BC34E50DBFEA" modified="2023-09-13" version="1">MDVDWCIEKLTKNPPEVLPEQIVKEICDKIKELLIYESNVAVVKTPVSVVGDIHGQYYDLMEMFKVGGECPDTNYLFLGNYVDRGYYSVETLSLLACLKIRYPSRITLLRGNHESRAVTQVYGFYGECLRKYGNTNVWKYFTEIGPGYLFGQDTVNKFIQGNNLSLIVRSHQLCLDGHQIIFSRKLSTIWSAPNFCYRCGNVATILEVYNESDKESDPIFNFNYNTYTAAPDSERIFPTLETAKDIPDYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8F9</accession>
    <name>A0A9Q0L8F9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8F9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68436" checksum="9A4F7528CAC4EDD5" modified="2023-09-13" version="1">MNEILFFGANQYPNLFKNKPNEITKPIQFKFENENENENEKQIKKVSTGEYSIIFLFKNGKAIEYLNKEYSKPNPEKIQIENIQKISVGKNVEAILTKEGNAFAKGENINSNNPNEFINISSLIEDTNDRIIEDIASGLNTIYLLTSNQNAYGIGSNEDGQIGSDYEILKETEKPILMMKNVSKIFSGSYSKSVFLLNSNQELFGSGNNFSGELGLGESRKKETKIKKLTKIQNIPKGKIIDIQSGGWHSIMLIEKEDQNENPKRKLYSCGHSNYNGKDETTYEFTEIKSSLFENDDNIIDFSVGYFHTLILTSNSKLIGFGSNYFGQLGPKDTPTVFKKKPTLIEFPELRFNEDIFNYHVYCGNSNSFLYYSSPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIKAHKLILKYRLNQNQNEIENLQEIISTKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSDKSFQIFEYWIYSNQIKNEIQITNDIIEEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8S2</accession>
    <name>A0A9Q0L8S2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fam11a b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8S2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="587" mass="68173" checksum="84814A187C0BFB3C" modified="2023-09-13" version="1">MEFNSFKKNSNENLQLLEEESETITETEEIEESIQALQYEIFRNKGVVVLTEMDFVQLNRGEFEPPPNKPKQPFQKENLILEILPPELILTIAEFLPPGAIVRLSLTCKTLQQLCQDQYLWRQVSILYERYYVWDKLEVTGNNLSIPNNIKVVGFQADIPKKIQKIKQKLEQEKKEKKEKKEKQNINTDLSLTNQNLIEELGEKDLKKPKKIGKIGKKIEKKIGKKIEKKIVKKKFKKTKDSVSRRIKSKIIEDENSNYAFDSTTKRGVYGSVSPTYISVRSQRIEYIKLLKNPKKHLISKSQKLSELLELKEKRIQETMIQRSQNIQQWQNKKKIERSIYCSFSILHFGLIAFIALLNLQLEHKLDTKISYTMIPLFVPLIFIVVFFLIMTQFEGNESLVLDGGISFVTLIFFTGVLLIGLKLDSMIHISWFVVFSPFFVILTFPFLITFAIFLRSFDIVVGLALMMFLFLFSFLVLLALQLDHIISWNFAFIFAPIFLFDLVPLLGFVLAQFFVYYPELIYLSGAAFIIVIPTSIFEALVVVFLSSSSMKKITYAFFPLYVWLLLILIVSCPGFFYNFSRLLSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9I8</accession>
    <name>A0A9Q0L9I8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">5'-3' exoribonuclease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_12103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="8">
        <location>
            <begin position="1202"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1332"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1351" mass="159453" checksum="05F45067AC35CEEE" modified="2023-09-13" version="1">MGIFRFISTLKKRYPAIFQSVGFIQPDIDYFYIDLNAIVHQVSHPEEKEINPFFYISEDDIIREVLNSIINLVELIEPKKELYLGFDGISPLAKLKEQRERRFASVQKAKLNPKNPRIQKLKFDPNSITPGTQFMKKLDKSIEYLIREKINNHPLWQKIKVVFSNSSVPGEGEHKIFDDIKLKKQSNDYSINDTYCIYSPDSDMVLLSLATHHKNIVLISNIYSGNYFKNLKLQSKTNQEKYQFIFINLLREYLIFDFQEKLDLVKNDFERLIDDFIFVCLFLGNDFLPTMIGFEIDKGGLNILFEKYCEFKSKFGYLVNKDKINYEQLQIFLSLIEEYQEEFLKNNPKFLQKTIKFYENQNQNQNQSQSQNQSQNEKEIEIENEKEIENEKEIENEIENENESQNESQNESQNFDDSKHVLNMEDTVIEFEKIDEFIDSQNNDIEEKDSDAPNNSSLNSNLEENSQNDSETFSYLEDPQDELHFNDQNSEDKMNNEYDFEKPPNMNIYDQDEQVSDDTLYDLKEEYYSKLFQQEYSSNHIEKVFQSYLQGLAFCTSYYYYGTPSWDWQYPYCFSPFLKDLSGYQEFFDNINFGSTEPLPILYSLLMVLPPQSASLLPESFRSLLTSKESPIKHFFPENILEIDDFSTREARINFANYVPIIDVETVVKAIKEADLENKLKKKEKELNQYNWDNLVFKFSQKISREIIHSNIPGFKDLKECKSTKEIQKIIRKFEPKKQTIQFPNQENQYISSYIPYGFPSFSFLQFQSSTNRYYPMVTIRVLNGDFNYSTNHLDYIGVPCFINYPFFFKARITGIVFNNGWYYNQSESYQINYEEEVEKTLGILSKQNGVTLQNNPIAIVYASSENEETIYNFQNDSNYNYNYNYNYNSNSDYNSNLDYNYNSNSDYNYNYNSNQNLDLWNSNSNSNLDSNYNSNPNSVSFQVPLDLVLFDLFNVTNKRKIDYKILNEENVIYIGKKYYGATGKIIQSFPEKHTFSIELSSFHQFRHNKLRSQWISILTVAKIMRTRLSVLQKILRSIYIGKYNIGLNFYFYKESLLKPGLISYSNSWQTRNNDLFLSPDAFHILQNYKRKFPQVFYALNRLKPQNDSHFKFFNNIKLPMRENEYVKVVFEWIQSLPSSQIELQHVSSNDFCLMKSQVRNLDNFYNPKKFRKLSKLRIDNVNESLLIRGNQQTDSITSQQYLDLGEKVISVNKTGIPPFGSRGTIIQINQTTKTADVLFENEFVGATNLGGRSLFRKGARLSTRDLISLNNINYNYNIPENKIKVQKISSPKNFKKNDNQNQNQNLNKSPHIWTKKKKENQNQIENQNQNQNQNQNQNQNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAK3</accession>
    <name>A0A9Q0LAK3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAK3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="70" mass="8885" checksum="C3BC4EACDCDA034C" modified="2023-09-13" version="1">MISNFKLWKYSIFIERRLKNNMIENLFEFKFKKTNLLFVYESWNSQYKEVIWNRIKLEFEIGKKEERIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBI9</accession>
    <name>A0A9Q0LBI9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_11260</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBI9"/>
    <dbReference type="OMA" id="TMANIPW"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5070056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="630" mass="73781" checksum="7953328D323D37D7" modified="2023-09-13" version="1">MNENIKEEKEKKEEKVNIKILYSTLTGTTKKFALTLKQKLLDQKLSTFFPQVFEISEYDPNDLQDESSILIFIIATLNGGPPRSAKTFSHFLTDLVNDQRIPQNYLSKLRYWIYGIGDLSYNEKYNKFARDVDVYLRKKGGNSILKKGLGNHGNKFEELLLHFNRFTDILVEKLKAILKPNEKLNENVILHNDKENDKDIDIDIDNEDEDEDDNFENDENDENQTTDIEDVEMLTPIMNKILTKQKYITVGTHSAVKLCRWAKAMLRGKGVCYKHAFYGIISYSCMEMTTSLACANKCIFCWRHNKNPTCTSWHYKQDPPEMIYQGSIKAQKDLIKPWKGVPGVTSDRYKDAFNVRHCALSLVGEPIIYPQFDEFTDILHENRISTFCVTNAQFPEKIESIKPVTQLYLSIDAPTKDILFELDRPLFPDFWERFLKSIENLAKRNERTVFRITVLKQYNDNFIQNYVDLIKLGKPDFVELKGVTYGGFGTNPKVSMNNVPYHQEIVKMAQEFMENDYMKENYGIACEHAHSCGILIAKKIFYKNNSWHTWIDFDKFFQLFQEKKPFTREDYMMKTPDWALFGSKEKGSNPKFIENMEERLKNKVTDIKSNENEKENQNEKENEKEKEDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBY9</accession>
    <name>A0A9Q0LBY9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide-binding protein g(O) subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBY9"/>
    <dbReference type="OMA" id="HKPLYTH"/>
    <dbReference type="OrthoDB" id="10547609at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="361" mass="41811" checksum="47EF5BE330A518E8" modified="2023-09-13" version="1">MGIKSSRTKKLRKLEKKKNAIIEEQLQQDQLQEEKEIKLLLTGTGDSGKSTFVKQIQILFKEGFNEDDQKAHKQVIRANLVFHMKALIRAAEELNISLLKENQIIAEEFLDLPSVSKGEIPDDVVDDIKKLWKDPGLKKAFEKRSDFQIPDSSSYFLDRIDEIMKVDYLPSQEDILRCRIPTTGVKVLSFDLEGYPWKIVDVGGQRSERRKWIHQFDNVTVLIYVVALSEFDQKLYEDESVNRMRESLALFEKTVNNPTFKNKNCILLFNKRDLFEEKIKQVDLSICWKDYNGGLNYDKASEFIKKKFESVGKSKSKSKSKSKSNRKIISQFTCATDTNNIKNFFKSITKTVIDSHSKTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC94</accession>
    <name>A0A9Q0LC94_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein mei2-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC94"/>
    <dbReference type="OMA" id="REIDIHY"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12276">
        <property type="entry name" value="RRM2_MEI2_EAR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="122"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="374" mass="43673" checksum="91E126AEA1A6CAB0" modified="2023-09-13" version="1">MSDYHRHRRDSFHPYSRRDSESRSSRRRKKKRYATRTLFVRNIAFEATIDEIRDEFEKFGKIKRIYDIIKKRGIAFITYYDMRAAEAATRKLQNKKISGREIDIHYSVPNSTSQDDPNNGTLYVVLKDTSKVINNDEFYKFYQKWGDIKEIRNMRNNENSKFVEFYDLRSSEQALKDTNGKEYLGGTLIVKYAYAPKDKRSDERDERSDSTQSIPTNYRGIPLPTSMKDLNIGETIPPTPLLFNNPQALSLLNAQLLPQLQKTDPLNFQPQILPQLLQPSIQTQPQFTPNFLQLSGLLPNLQQHQQQQQQQQQHQLIQQNPQIPKENNLQDLLTLLLQNQDQNKLDPLKPNLQGGLNSDNLNQLSQFFSSHSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCV7</accession>
    <name>A0A9Q0LCV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCV7"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="334"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="437" mass="50573" checksum="46F10E2E81D4BA43" modified="2023-09-13" version="1">MNKKKVSHPLLKAIENGDEKKIQKLMKKKIPIKILDLALINSCQSKKISIAKEIIKKGVNIDCGEIFTPLHYASMFGDENFLFQVLEKKPNLEAKTPGATPLHLSTHHGHYNVVKILLEKGAYVDSVTNGSTPLRFAAKYGRFEIAQLLVKFGAKIESRNNGWSPIHFAIRFHHEELVDLMLINGNNDDYVTNGLSLIDLAENIQIKEKVSKYLDQIKSFQKDFLDLYEKQEFFDHEIIVKDGKISVHKLIINTRISPHSLLDFEIQCKKLKRNEAELLVKFLYSGIIENKENETDIKNLLTKCNFSDSFIEEKTKKYSLQEDLQKLYNNEKTKDFALIVNNKEIMVHKIILIARSDLFRGMFLAVKDNSNKVNDYSGYSQETINHLLYYIYTDQIVNSLKDDVIHELKDSIDYFQLNQSSSLDWKLKQIQSRNRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCX5</accession>
    <name>A0A9Q0LCX5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCX5"/>
    <dbReference type="OMA" id="DKGDCAL"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="19969" checksum="87FC6E165B65B541" modified="2023-09-13" version="1">MPPKRNNKNKKSQKGKQQQKDTETDTTQKETETNQQNQQQPQKQNQQQKGKGKRKGRRNQDEDFDKIMEENQEIIENELKENDKKEDDKKDEDNKQEDKQEESKQQQQNQQKQNQKQNQKQNQPKNKIKNKIKNKINNKKEKEKEKEEEIKMKILIKLWKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF24</accession>
    <name>A0A9Q0LF24_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF24"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5072081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="90" mass="11022" checksum="45B42E450B069F01" modified="2023-09-13" version="1">MIYSNNSKINPELYYEIKEIINPNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVKMIHPIKLQIIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF44</accession>
    <name>A0A9Q0LF44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication protein a subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF44"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor A C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="139" mass="16404" checksum="D71A5B56C21A663B" modified="2023-09-13" version="1">MYPSCISENCKKKVNRQDNQWFCSSCSKKMQNCHWRFNLKARIHDYSGSCFVTIFDQTAQSLLGISANQIQNIIHSGKIKEYHKIFQNVKYQEYLLKITKKNSKKFMNSFVAESITPIRNEIIEYSKYLIKIIHSYSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFH3</accession>
    <name>A0A9Q0LFH3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine-protein kinase nekl-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFH3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="455" mass="54927" checksum="1FB4CF026232788E" modified="2023-09-13" version="1">MNESIKEIINTKILKEDKAYSPIPYYNKIEKYFYMKINKNKMLPYIELNQSSIGKLKCYYEVEEDKQHKSYIIRFKNKYEGTLKDYISSPNFSYLQFIEFIKQLLLGIHYLHSKNLFFSDNLQTISLSSILISTKRNNAIFTQLFFKEENFVYIGDAIKETQGLVNQDMNKFLKIFQDTKLNELREILFPEEEYNKLKKQKKEYSLTPLRLLEFSFFHEYSPIPKSFELRIESILPRFKRICYGQNVYIYDDTYDKISKLIDLSYCSTETFITPNIDIIEVKQNKDITLYSLYSRYKKQVFSTRDIIQKDEIIQLKTTDKLDLNSINECYLFSGKRFDSCSVIEGILNEQLPEFKNFNIPNSKHFFENFPIAHEYSTVDIESGLHTIYIYRVCLGRFYRMNQNEKFDYEKMKNYNSIIIEVSNKEMKSRYTQYFVFEQFSYYPEYEIKYRLHNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFW2</accession>
    <name>A0A9Q0LFW2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Jak pathway signal transduction adaptor molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFW2"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="109" mass="12594" checksum="667F69CB58B13A23" modified="2023-09-13" version="1">MTTKKLEPFEVLAIADWIPQDDKELAFKKNDKITIIDNNYNWWVGYIEKSQPGLIPKNFISFDSSKIETENLNSQNQTNIPPKPKKTNYITSISKSQNKTDSKTRKSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFY3</accession>
    <name>A0A9Q0LFY3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFY3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="19546" checksum="B8F456FEBFD38708" modified="2023-09-13" version="1">MDQIKKIISEKIEPLIKCKNLSLLQLFFIFRLLIASFLILITPFTPTINPMFIFLKMPAIFLSIPSNLNEKKEIIKQKYSKFTKNFIWIYALFWVIVYQFISPRYNLLSTTSLLFAVGSFFHSLVWTVFDSLEFDFDIEKFIENYFKIIESKLKIFGIKKQKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG61</accession>
    <name>A0A9Q0LG61_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tobamovirus multiplication protein 1-like isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG61"/>
    <dbReference type="OMA" id="RIVWICF"/>
    <dbReference type="OrthoDB" id="19353at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="7">
        <location>
            <begin position="11"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="283" mass="32939" checksum="C29F03A5EFF3DB85" modified="2023-09-13" version="1">MKSYFIGGLVGYLVLWLFSVIGLIRLYISKKRLYPYSKLQIHFHILLFCFLIVRIVWICFEGSSDITALLILNRYACTGFFTTFTYIIFFWAEIYHFLSHLSYRIGLDKLKIPFIIVNVCLYIATTVYSIIFIDDEVTHRKRGNSDPIYNSSVLLIAAISFVASLGFLVYGFLLLRQIKKAISVVSSKKKSLVRMGIFTVIFSLCFLCRFIILLYRPITNKFLAEGLYFSLSYYIPEMVPSLIQLSVMFPSFPKSFIQPIQEKETIFQNQDDESLQPYFLQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGL4</accession>
    <name>A0A9Q0LGL4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGL4"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="6"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="395"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="497" mass="58560" checksum="60EDF89FEB8E02E0" modified="2023-09-13" version="1">MNSKFFGKHEAEVRYLYINGEFLYSGGFDKKIRIWEISTGKLIKERKTTSYIFCLSVYNNKLVSSGGKISVWNIETLNLEKEFKKDFEGYIFYFVILENFLFTAGGDRIIRKYIFNKGICKKKLTGHSSGVWSLVLNSGFLYSSDSSGEIRCWDIQSLDCQFILKAHNEGIWGIGFFKKFMYSVSNDKKVKIWKFENSYNKQPICDIELTNHTGNIISTFLCDDILFTGAEDNKVVAWNLKKRKFKKTFHFNSKVWNVCSDRKRLFAGLSDHTIEYCDLDDMFPDSLVQDLEKLFKRKENCDLIFQTLDRKISLHSLIIKSRIQIPISKLGDYFAIKPYKITKEFFRWIYTCRTKLKTELNDICQELEIKDFAEKSTFKSLRFSISQLYFENQSKNFNLIVNNKEIPVHKIILQARSELFRGMFVSVEDNSNCVNDYSSRSFESLNALIKFLYFDQLEENLEIKYLNELIDAVDFYQLNKISELNNEIKRIKMKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGM0</accession>
    <name>A0A9Q0LGM0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGM0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="85" mass="10344" checksum="5450246C65048FCD" modified="2023-09-13" version="1">MKINKNKMLPYIELNQSSIGKLKCYYEVKKINNIKSYIIQFKNKYEGTLKDYISSPNFSYLQFIEFIKQLLLEFIIFIPKIYFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGX6</accession>
    <name>A0A9Q0LGX6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Replication protein a 70 kDa DNA-binding subunit a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_09086</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGX6"/>
    <dbReference type="OMA" id="WINCHIS"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003871">
        <property type="entry name" value="RFA1B/D_OB_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02721">
        <property type="entry name" value="DUF223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication protein A 70 kDa DNA-binding subunit B/D first OB fold" evidence="10">
        <location>
            <begin position="264"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="12">
        <location>
            <begin position="386"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="11">
        <location>
            <begin position="557"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5073131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="713" mass="84669" checksum="E3B42F5BE1485337" modified="2023-09-13" version="1">MSAKKLIQSIKKGSKKKVILSIEKVKKEKDLIKLLLKDNNEEINGIIKNFSKKVSLKKGNEIELEKFKYDAKEKLIKIEEYSILEDEDEDENENEKEDEKENEDENEDENESEKENEDENEKENEDEKENEKEDEDENEKEEENENEKEDEKEIEDEKENENEKDQKEDKNQIEKEDEKEDEKEKEKEEENENEKEDKNQIEDKNQIENQIENEKEIENQIENEKEDKNQIENENQIENENQMEVESTEQSSQINFQEENCIYFSQLNPLLTQFDMKVRLVAKSDPKTYTIQNKTSKLLPLVLMDEKKQEIRATIFNDLIDKFISEIKVGELYLFSNGKIKLAERKYAPKNSIYEITFIPETKMQKLPEKYAENFPNIDFELVPFSKIESIQEQTLIDVIGILEDLSPLEKIEKSGEFSNFKRKGMLVNKDYQIDIQFWGSTAENIESTMKNYLDSIPRQEDKIPLVAFKQVRVMSYKGKYLTFTDLSQSYWGPNLPEAEEIKNFYLKNTMKKGLAQQIKTNTLTNLSYQDVGIDQRYLISKVNKLEDDKRNLPEFVFVQGMVAYMNKDLDKIMYPGCLNSHCSRKVVKNKDLWFCSNCKTLNKKCQYRYMIDMNIQDFTDSMWCICFNASGKRILGISADELMKLKEENNSQEIERIFDQALFKRYICKIRIQKHIYQEKEKVTNTLVYLDPLIERIREESRILIEEIKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHF9</accession>
    <name>A0A9Q0LHF9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_09824</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHF9"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="346"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="901"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5071925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1264" mass="144299" checksum="16D9229686A39EB5" modified="2023-09-13" version="1">MEFPSQNELSQFTFPKFQIRQSYSAEKDQCIEFLEKFSEDSNEYKYLDKIKAIIQRKSKQIEIELDDLISFESPNSTLVKNIEKNTMRYCDIFAEAVDQIIQKISPEIPQIDIEDVNDIITTFRQQAEKNEDSQNTSNNFPPDLLRRFEIRIIPRKKTKVTKLRQVKSNCVGKLVKVRGIITRITQVKPEIKVATYTCETCPNEIYQEVTSQNFIPLSECPYCKSNGVTSVLQLQTRGSKFEKFQELKLQEISSEVPTGNIPRILTVNLHGELTRKCSPGDGVTISGVFLPRPFTGFRALKAGLITDTYLEAMQIEKEKKTYSELTQYSEQEMIQKIETSSKDPDIYTRLAQSLAPEIYGHLDIKKAMLLLLVAGQTKEMSDGMKIRGNINVLLVGDPGVAKSQLLKHITQISPRGIYTTGKGSSVHRDEKVFVKIGKEILLESIGNIIDKQLENNSQKKMEQNSILAKPKQPLEVLSVSPTGNVKFSKVYCVSKHLSQENLIKITTRFGSKIIATKDHSFLIRGTNGCIIPQKGNQLKKFDKIPILKKLRIDKKMIVEKIQIYDIFNNKQKKKIISKIHNKPLSKLTNEEKYQINTVYCKLENSKEDVNNTIILDFHLGFLLAAFLTNGTKVSEKTCKISSSNEEYLNFCREIIQSKFKYKCKIVEEGNSKFLEIGSYIVSSLLLNLSRNQEGDEEIIEQILLSRDSCVFGMISGFFNNTEKMIQFKGTRSGFAMNSSKLAQKFQLLLNRIGVDSRILISLNEETLQKQYQMDYKEKKILVDYGNGNITQIPFKKLVYNGTPKILFQMKYEEKIKLSNQNKTYQYCVLVEAKYSRFFGYQFEGDHLESGINDEKNKISKDVMFDDIIGIEEIPKSKHEWVYDFAVDNESFMLSNGIFVHNSGVGLTAAVLQDSVTKEFVLEGGALVLGDMGVCCIDEFDKMDEYDRTAIYEVMEQQSVSIAKAGITATLNARTSILAAANPSHGRYNPRRPITENINLPIALMSRFDLIFILIDKPELNSDLILARHIAHVHQYGTPPDLGFEPFSTDFIRAYIAQAKQIDPYVPEELSSYIVESYVSLRKNDGFLQMANINNQMDQTNNDEKMNEKENNERNINQSTISQTDEPITPRTLLSILRLSQALARIHFSEVVKREHVDEAIRLFYISKASVDDPNYTITSSTSKTKIPQRYPDPKTAIYNIIRDAAVVPDDTNEGATKSVKYEDILPRVLSRGFTQNQLDNCLEEYEKWNILQLNSNRTIIKFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIB2</accession>
    <name>A0A9Q0LIB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab3-gap regulatory domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029257">
        <property type="entry name" value="RAB3GAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491">
        <property type="entry name" value="A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491:SF156">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14656">
        <property type="entry name" value="RAB3GAP2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="2">
        <location>
            <begin position="91"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP regulatory subunit C-terminal" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP regulatory subunit C-terminal" evidence="3">
        <location>
            <begin position="1385"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1652" mass="193016" checksum="D6A18492229F1754" modified="2023-09-13" version="1">MSQFQLSKIANINFRTLLPLIFFDNEQNPHSKIYSFQSQFTEKETNIKNESKENSENSENENFEVLTDSESDSTTQISSLNKLDTTFPFELCKIALNQRGEFLAIAKDTRLFLIPLKNKSQGIIIGQENHMQMNEVPTDIVCVDIFSKQNLQISSLIIVSFESGILNIYDQNGKFLSKIKILADPIQKIKAKTSLNIKNQQKITELLILSKNTFVLINTDDLIEYILQNNNINNNINFWQNSKIYSFFDQKQISDFDYLSRFQNKSSMHSFYSVGKDPTICSLVKKNQNQNQNQNENENENENENENENSKNSLLDSTMNAFGNIKNNMVDLFSSIFISKPQENNNNKNKNKNNIKQKAHRKNLFTKKIKELQIYLQKNTHQFGNQILVDSLKKIVVVSDSLGRVLIIDSENLKVIKVLSGHKNPQISWIKCKTKDFLAENNKSPKNVSLSKSMFVKPSHNVPKKPDILCNKYLSIYSETQNIIHIWDLDILEEIQTIKYGEQMFALKSSDGYIICENFMINFESELEDENEFENESENELESENQTNSETNSETNSESFSSFSTTQSSIEIDNSNDEKPKSPQNNKFGYTIAIENPKNKNPNLNLNYETIQNLYLPQTDSTIFFLDSNGNVYHLEYISPSNKKKQSRTQKSFQESRDESSFSELKQFFTKYKDDQNQQNQLFIILKNFNTSFYANKALNFIEKKYNSQILTETQLLNGIKLLVGNIVGVHKTFTFANTNIRQITSPQKYKFHRNFHPLNRLEIQKNNTKNTISQDILLIRRQNLVEFYVLMKKEHQKNEEMKKEKHAKIFLDESFAKDLFKTLNSNLQNSIQTKVEQRIDFGKFTLMDFIKCFNYRNFVSTFESNDFNYLNCGRFLFDTLLFSSSNIFSFVLEFIQFIDLSTIDCLDLFTKWFYSSPLSLLFKSRMDSLNITQMEHFLFEFIFSNQESIVKISSNESADPNEQKIAFFVHKNILEICDYLYKICEESTQVEHSLILAYLCFHVFDEKRILLHLNKEINTETQKTEKEDAKISNIEHDANSTISSISQKWITITNKIAVALFINQNLSLFPSLYNKVSVHQLSTNPKFNLSRLIAICDIFLHYSETEKIDIVVFIHLMNEYLENRAKNIESFVNKKKYKKIDSVSVHSKEYLKALNAFITKFPFFANGNTVNSFKAIELISFWKAYPFTDMILSHCLETINLISSPEIKLTTCTIIWNQVLSSLISNFMVLFEDFRSSPNEYSIFQRLSLRKNQVDLLLTFANGLLSIISHYFEENLQNENEKENEKENEKENENENENEKENQNQNQNQNQNQNQNQNQNQNQNQNQNQNIDEKEKDIDLDSYKGWPPDLSTPNHKSILEQLNQLFFQENTPNEKEKITLNLQQLLSIFTLLLEILRLGTTYTFNHLQPLLLFPENLRNILFDPKLIIHKIPSIDLQNTKIETKFIATVTHEIQNEKTKKHFSQFNFDSIKAFYLIPNKNTKNTSLDQTIMNFILNLFEFDQKEAIKFANNLLILPDIVRTERIVKMYENHKDLKAEEEIKFIKNTHELGLRLLEISKKRLKLLINSLKELDKKKFIADLSTEIYHFLDLSKPLNTLKDDNDFNTLNLSLFTQNIYSLILRTISLLDENSHQNKMAKKLLEIAKSLISFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIH3</accession>
    <name>A0A9Q0LIH3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIH3"/>
    <dbReference type="OrthoDB" id="10666515at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5072053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="517" mass="59626" checksum="7DC323F7B414591C" modified="2023-09-13" version="1">MTSIQKYLEQISQQENIQKIYDFLEQKINEFTDFQLQNNDSNSFVGFGNIKDKKDAIIVVEIAIPNIKKEEIEITKLEEDEKNKTYKGKNISIVGKIAVFLDILENFKSANCALLFSVINDTSDIATTLNVCKSIHTNEKYHLSIYQDTTLDLNKGIGLVTNSTRRWNMSPQRTGKTIKFIIEKTYEPDFYQSQEAETKDDFMSRCVEKYEEQEFENLDFCFPLKNRFDDQEEISLGDLEKISRTLIRTLRRLDNARLVRFPEKRDVKKYTVQGWTPPEDFNSDLLMQLLRIPSPSDYETRVRDFITNLLHEHDVPFMEYQGNLFWVQEMGRPMLCAHMDTVQNIDDCIYISAIKMENNIVSGEGIIGADDKCGVFVILDLLVRSKIKFNWLITCQEETGLNGSRNFVASDYAYALLDFPYCLVLDDIESGLIRCFEVGFGTEAVEDFLVNIGRDFQFFGAISPGICDSHILKQYVSSPSISVGAYNIHTKDEFVDLRALVNARGFIEKCLLTEFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIN8</accession>
    <name>A0A9Q0LIN8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_08862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIN8"/>
    <dbReference type="OMA" id="IDGSAVM"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="198" mass="22435" checksum="9374AA3DB640B4BA" modified="2023-09-13" version="1">MGDELYKLVVIGGGSVGKSCLIVRYLQGKFIQDYDPTIEENYRKMVIVDDRPSMLEILDTAGQEEYRTVRDKYLKQGEGFLLCFSITARASFSEAKNLHESIRLIKRIDTTPVVTVGNKCDLEDERLVSQEEADELAAKYNSEYIETSAKTGLNVHAAFEALVRRVRKFKSESKSVTNQGNSKTPQRPTKKRKKCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJR4</accession>
    <name>A0A9Q0LJR4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Wd repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJR4"/>
    <dbReference type="OMA" id="TIAMDAC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="365" mass="41420" checksum="322EFD3EB714D4E4" modified="2023-09-13" version="1">MSDNSLEKNSFSETEHQTEDETHAFLTDSPTQDDESGRISLCPKKDVYTFESNWNTFSLSWALRPENPFRFAVGSFIEKYKNKVQIVQLDEEVDELFEVCSFDHPYPATKISWSTDKSLNAPDLLATTADYLRIWENKDDDVQLTALLRSNKNSEYCAPLTSFDWNEVDPRIIGTSSIDTTCIIWDIEAQTTTTQIIAHDKEVYDIAFTKTTNTFGSVSADGSVRLFDLRNLEHSIIIYESPGLIPLLRLAWNKLDSNYLGVVLMESEKVVILDIRIPSIPVTELEGHNASINSIAWAPHSSCHICTSGEDRQALIWDLSKVPNPIEEPVLGYTAEREINNLQWSSARNDWIAISFANKTQILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK44</accession>
    <name>A0A9Q0LK44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centromere protein t</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK44"/>
    <dbReference type="OrthoDB" id="10071681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="40"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="17479" checksum="E5721CC15282D0C2" modified="2023-09-13" version="1">MKIKIKIKIKNQNQNQNQNQNENQNQNQNQNQNHKRQKIHSKPEFPRSLTRKIFSQFCKLRIEEDAMIQILKLTPLFFEQLSNDIHQLSNENDYISHLHFFSLMKNQRFISEEKEEEDLKDFIQKILPFELSEIIFPIARAGNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKH8</accession>
    <name>A0A9Q0LKH8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKH8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="301"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="418" mass="48109" checksum="DDEF801659E3D189" modified="2023-09-13" version="1">MNEIIFFGSNQYPKLIKNKPNKIKKPIQFKFENENENENENENENEKQIKQISTGNFSTIFLFKNGKAIEYSNEENDSNQNPQKIQIENIQKVTVGFQNEAILTIEGNVFAKGEDINPNNPNEFINISSLIEDKNDRIIEDIVSGDSSIYLLTSNQNVYGISSNEYGQLCFDSETLKETEKPILMMKNVSKIFSGNSSNHIFLLNSNQELFGCGYNYGQLGLGESRKETKIEKLTKIQNIPKGKIIDIQSGNYHSKRKLYSCGYQNTYEFTEIKSSLFENDNNILDFSVGFEHTLILTSNSKLIGFGNNGYGQLGTGDTKYHLIPIQIELPKLRFNEDISNYHISCGEFRSFLYYSPFSFSNLEEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLNQNQNEIEKLQEIISKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL68</accession>
    <name>A0A9Q0LL68_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear fragile x mental retardation-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL68"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="122" mass="14286" checksum="5D1BB3CC394A2B71" modified="2023-09-13" version="1">MNKNKTKSNLLIIFCYSKGILSVIIYLPHTPLYHQIYEAEWCLIDILTEMSQKKLLKINQLESILSLLLSNLSPPSHSNFNENNQNNQNNQNNQNNQNNQNNENNQNNQNNQNNQFNQNNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLI8</accession>
    <name>A0A9Q0LLI8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLI8"/>
    <dbReference type="OMA" id="CEECCMD"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="198"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="43863" checksum="DD8FE17FC7F8E146" modified="2023-09-13" version="1">MKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILNSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIENKEKEIEDKWKKEIEDKNKEIEKNQKEIENKEKEIEDKNKEKENQQMKIEIEEKWKKEVEDMKSKFELMELQKIFSDSEIVQDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGFKPNGGDIKDSSAFIFSLRNDKGDRIPAKFTIKQGQEGYAICSHLSCGPIFGWDGHGNDFRLESNLQGHSNFGHSYNLPNGITCGTNKAKSYLAGSYDKWIVDELESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLJ3</accession>
    <name>A0A9Q0LLJ3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLJ3"/>
    <dbReference type="OrthoDB" id="6139842at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33456" checksum="47B2A6538136D8FF" modified="2023-09-13" version="1">MIMIIMIMIMIMIMIMIMIMVMIMVMIMVMIIMVNNDNGNNNDNDQSNHNSQSNSSQKMSLGIGKTIIEEKNQIIFVERDQLIKLIKRCPTCGSQISKVEGRRGPGHHYEMYWECKKNNHCGIWTSSSKTCTNQKIINLKFQNAIFLSGIHFEAYERFLGILESKPVSKTSYFNYQKQLITQVIEITNRKLQKLRTKCGGRQLVILVDGRWSRPQRNKTKSEGYFCTVIAIDSLTGYVIAVCTKTRKKKEEDKGKLEAQCVVEVLKQFQTERIFLSISLSLMPIHPLINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM37</accession>
    <name>A0A9Q0LM37_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_07377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM37"/>
    <dbReference type="OMA" id="QCEAYML"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="228"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5075407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="806" mass="96064" checksum="8CF5428CC43BA936" modified="2023-09-13" version="1">MNEEKKENQNQNQNQNQNENQNQKENKNEEKKENQNQNQNENENENLNQNENQKENENQNENENENENQKENQNENQNQNQNENQNQNQKENQNQNQKENQNQNQNQNQIENQNENENLNENENQKENQNENQNQNQNENENENQNQNENQNENENQNQNQNQNQNENENKNQNENEIEIQKENKNQNENQINIPPSKRKIDESLYSTTAIAQKINDFQTKSIRSGVNGLHNLGNTCFFNSICQCLSQLVELRDFFLKERVKKGEGGLYQSLRIFYIYMWKKYDKESFSPSIVLKQITSYYRKFGSYQQQDSHELLRCLLDTVHEEELGRLKKHNLLIEEVNQNQKENQKENQNKNQKENQNKNQKENQKENQNKNQKENQKENQNKNQKEKRTKRKSKQKSKQKSKQKSKQKSKQKSKQKSKQKSKRKSKRKSKKIKKKQKENQKENQNKNQKENQKENQKENQKENQKENQNKNQKENEKEKSNKSKNKKPKKPRPHLNSPKNTIIEEFFRGTISSNVKCDTCHQVSTIYEHFFDIHVAIAGSKDLKNKNKKKNEIVEDSIDKKLKGKDNTKKNKKDNKDNKDNKDNKDNKDKDKDKDKDKDKDKDNKDKKEKDKEKDKDKDKEKDKDKDKDNEIQESPKLTDASLISSLQYYFQPDILDGNNKYYCQFCNKKDQTNKKKKDKKKKIYRKATKQFQLEKLPPILVIALKRFTQTGGGRLRKNGTYVEFPEILDMSQFFLNSTTPQKYELTGVSVHGGGMGGGHYIAYTRTSDNDWYYFSDSSFHRVSKESVLKSQAYVLFYRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM67</accession>
    <name>A0A9Q0LM67_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040220090" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="454"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1339"/>
            <end position="1406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1424" mass="161905" checksum="E163733F5D4FD87C" modified="2023-09-13" version="1">MNLILAIFLISNIFLIGSIQSQHISTDSETSKYYSSEDQSYVWGLINNFTGPSSFGGTLAMYKDILVAGSFNIEQVAVFRYNGSKYVLEQNLSGPSGSSFGSSVSVYEDTLVISAWNVNKVFIYQYNGSYWNLGEIFNGSLAEGYGFKVSVWKNFLMVSAIGVGKICFYRYDEISWINEQNLTNPLSQVLGWSNSIYENVTVFGDHRRSISIFRYNGTSWNLEEYIYKELINSFGDSVSLYGDVLVVGAPDPGEVLIYRYNGTFWNNEQNFTTQLASDFGKSLSLYEDAFAVGNMITGNVTMFRYNGSIWNFEQNFTLFGSYSSFGYSVATYGNFTAITSWNNKTVFVYQHIQIPQVNTLNCSSLFSSFDCYWDKIEFFRTLKYQINYGFDWIDIDSPILKDGNVYYQQFNSSIYDNITGNEYYSIQIKACDSETMKCGEGSSPLMNLTTRIDGVKNFQLSIPTNYSINVSWSHPNVELDSGIPNLDHYNLSYFKQIQPDLISSVSLDNSSTSYLFSNLYCGTDYNISIYGCRTELCQGEDKGEVVVVSIFTPFEEVQNLACSISYSLDIICNWNQPINCSTPFYYNFTYQSISQSDSGNYQPTSLNQQFTAQIANQDYQINVSACNSNGNCGDISTFSIKTDNLTSAPTIHETISKIEEIELNFTKVSNANNYSISLNNGTNWQNFTTLDLSGDNVIGTINGIGGNVQYNISVRGCSDLNCETPYLGDPSSISSIKAKLGSITSLSCYSLINGFVCNWDSLIISSGLEAYSFNYNSIPVCVHHQTPYCSISSGLNPGTNYQISVSQSADPNCLFNEYSGMNSTTSITPLSPCEPTQKTDNSSSNTTAITVGVIVPIAVIAIIIIGFIVFKKRRKNKIIKQIYNEKELRVESDTIIKPIQFKFEYENENENENENKQISSTYYSIITLFKNGKAIEYLFADFAFQNNQNPSKIQIEENIQKKGEDINSDKFINISSLIKDTNDRIIQDIVSGRNSIYLLTSNQNVYGIGSNQFGQLVLDSETLNETEKPILMMKNVSKIFSGNTSFSVFVLNSNQELFGCGYNHYGQVGLGESIKEEAKIQEITQIQNIPKGKIIDIKCGFYHSVMLIEDKNENPKRKLYSCGYCQYNGLGKEYGKHTYEFTEIKSSLFENDNNILDFSVGQYHTLILSSNKKLIGFGSNTFGQFGNEDEQIIEEIPIQIELPKLRFNEELFNYHISCGYDNSFLYYSSFCSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEETMKRIYLNEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQLFEYWIYSNQIKNEIEVTKEIINEIKTKIKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMW8</accession>
    <name>A0A9Q0LMW8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMW8"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="33"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="793"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1251" mass="147656" checksum="A197D730A2D34E70" modified="2023-09-13" version="1">MSRPQPPELLIILANVTKINHQKCFGKNDEVLYSPQKILINWVNSLIDPLQISNFSKDWKNGAPLKNLLSKLFPDLIFPEIEKIHGNQNRIKKMLEKFSETDYSGFTCLPKDIANGKENNILKFIAYLYIWIHVKASPEFEPFSELFPKNIKPKEKRKQSLNFSIQDPVVNFSENDDIEQYIVYTKPNRTLSSEEKLDKILTRFQLNRLNSLGIGENANLTVIEPKFNKRTAKNIHKRLSMENQNTKTFKWLQQAVEKELERQKSDPNVQGLKSRNKRRISNERYKPRKFFSFEKPPKLNRDLIKNLSQESPEKTSTQKKVMDDLALNSLQKSFTVQGFDYNFLDNKNQNKNKNQKNKKYFLHFDKKESIDIFLENQVKKKMDENTDKKTLQNQGNNNLSPQTIEEINKEEAKKEKIKLIDNLKSQLFRNHKKIQELNIKKEKIPTNPFYVKPHEISENQRYQFNISVSDENIEKYSDKFNEFILSNLFEISTLEDFEYQIQQILIFIIGNLKIEKLRDNPFFLELQNMVIDLKGISINLAFDTLFQNITNFLEENQIIQKKQNSLFELKRILIGGDNFEVDPFQIYFELNDYFETDNYWKDEPKELKNYIFSFLDFYSICMNFKRKLTFKLTSLISEEKIIQQGYSFKIYGLLHQYFNETVGGMNDIPFLQEVLIKLLERFGIEKHEKKAKEMIENSRKQSVGKILRLVTKHLFEDNKANQKSIRNNEKEPTESTSLLTCIEKGEKYLGTFLRRKDIEYLYNLMQLDLTQTAIGSLSTRITTLFEPFGHLAFLKFQISKHVFETSTPSFLFRSNEITSISLTNFAKFYGNQYLKTVLSHLIKEINDSNFNFEVNPELSSSYSKNTSHLRKYFKIFLQSIFNSVHLIPYHFKSICQHIKSEVSAKFPQTEFDILGTFLFIRCFCPAIVSPHSFGIIDWELKETAKRGLVLIASILTNLATGIKFGESKSYMKFMNSEISKNEKKLKQFFQKITQHSQFLFEESFNEAQPTQLQTVNFRPQTLCLENQKQTTTDLFAQDIFLIIDQFNEEDQNKYFGESTICKIGQFHQKMDLMIKEIEKLEIFFKFFQEFLFRFETDKTNTPDLDSLFYKEPHELKKNQKRLKFSTNNKIALYSQQERLNKKTIIEGEYLVCVKIKGIKKAWKKRHLVLKGKYLAVYEPSESTLSIPIDVIDIDPNCTIKEEPRSKYKKKRRLSLSRFGFPFSFWISFKSSEEFNDLFTKLKMTKDESSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN23</accession>
    <name>A0A9Q0LN23_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN23"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="254"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="472"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="577" mass="67310" checksum="4364EE05777BA85A" modified="2023-09-13" version="1">MNEIIFFGLNYEPILFKNESDSITKPIQFKFENENENENEKQIKQISSGHSSVIFLFENGKAIEYLNQNPSKIQIEDIQKVTVGLSNEAILTKEGNVFTKEMNIDPNDTKEFINISSLIEDTNDRIIQDIVSGSNSIYLLTSNQNAYGIGSNSFGQLGFDSRTLKKTEKPILMMKNVSKMFSGTSTSAFLLNSNQELFVCGNNRYGRLGLGKSRKEERIINKLTKIQNIPKGEIIDIQSGYYHSIMLIEFKTKRKLYSCGYFPYNGLGKNESTYEFTEIKSSLFENDDNILDFSVGRQHTLILTSKSKLIVFGYNYFGQLGTGDTNDQLIPIQIELPKLRFNEDISNYHISCGFNRSFLYYSPPSFSNLEEDLIKLFERKEFCNISFKTKNGEIIEAHKLILKYRLKDENEIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYLEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIEIGIDYFQLNQTKPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNG8</accession>
    <name>A0A9Q0LNG8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Desumoylating isopeptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNG8"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="269"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="68514" checksum="13C7219CFBE39661" modified="2023-09-13" version="1">MESAKIYEVYLNIYDLSMGLARTLSPMIIGKQINGIWHTGVVVYGSEFFFGGGICQGTPSKTPFGAPVRTVKIGETSISQDIFIEFLRSISDRFSFQKYNLFTNNCSNFSDEVCLFLTGKSIPNEITGLPQEVLNTPLGQMISPFVDSLTQMMGTNEDFGDFPEVPIIIPPQNQPLLGRQNTSPFSQQNQFSNPFGFPQQNQLSNARNFMSNQNNQNSQKNQNNQNSQNNQNNQNNQKNQNSQNNQKNQEQNPFISKTNLIQKFPNLKHTFSFSEPQLFLSQNHKQIFEDLLVLPTISPKEKNTFEFLQKAFNSKENIQFNVVKNALIFEQEQFSLDSILLAIKSTFTQLEQANPSPILDLIGYLLTFKPINLFFLKNFDANSFLFRNIIRGFNQNMDLISQSESKMKLVTSAQISTIIKMLRLECNVFSNYESIYLLKKNINLIKILSQTVNPSLLFGFSSQTSERISLLQAAGSLVLNISMILFSLKQDSEDIDEEISFPLITVLIHILSSNSFLENFGPDEDIIIYHLILSLNKILWNQPDSIDLANVLGLDLNSWLGSTNNRFNLIKRNLKTDLKHKFKRINKLKNLNLKEFALENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP60</accession>
    <name>A0A9Q0LP60_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP60"/>
    <dbReference type="OrthoDB" id="10692874at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="792" mass="94503" checksum="8495B893F9D9BA27" modified="2023-09-13" version="1">MEFVPIKSQNIKENLKNISFYCDSQIRAQFLYQSFVSFYNQTMYIPEKSIWNLLVQEKIVSLIPQIQTNFPSQFVRMDDILDIHKISSSQKKMEDQHHMLTELAKISFPKTNDFYDYIQTHISVDFHLRDLTPTVFQTKSRFEFVDIPFANKDYAKKLEKMENKFKIITKDEKAKFVVLDAHNPVSKFMLEMNSTFVTLSKLNQNQNQNQNQNQNQIPIPKFLNIKKDYYQVSYSSNFRIYLHPEKPDLFLFVGIDPENNLLFKTNHWLERDLIRYSFMHFKTNFLDEQIETKKPKEDFISCQLKFCRNPKHVKEKSANQNENRDCLFITSLSAPWKYIFEKNPEIENICNFIHKVGNKRSSDYIYIKHRETMEKDKKRTLNVLEKSKYKFCGLDSFDQFCGIVSIAFYKDHFKIKTRKEVQFREYSLYSKLSFDPIRKMICTFQIDEFIFIRVIFPDTKIRKNFIYDFNNRKEKKVGFLCDSLAVFDCTIKTPKESYLGKIKLKNGSFVIKSSILFEEFEYAPYRKLENIGEKFIKLYLDPCVFLTVIINNHSRFLMEFKNRTERYLSQSFGVSSIVYNAKIIRERNTQMDIQIFLYPGKFALISNYFAYVFNDGNQISLKIDDPKILKITFQSQAELTIEMQNTEQRHDFMINYQKNRFLYLSKFGYHKLDAKKTEFNVSFFEQKVDPKPGKILFQKDQLDDYILLVIESNKNPIQEKIYIQNINLFLHSSCIFACRMCVEHSEKDYTLGFSSRNELGIFANIFYKLKSSKKINEFIDFNFDFNSNSNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPM6</accession>
    <name>A0A9Q0LPM6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3b-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPM6"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="2">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="22995" checksum="0D667D9ABCE20B0B" modified="2023-09-13" version="1">MQEKIIEEEKTNLTKTSGHSYQEISEEFLNEKCSARSFLDENVLNNQFVSFPQGSEENSNKNLESQMDSNLDLDSEVKMEHFEEERYEYDMFLELNFRLLRKVEFLTRNLELIPNSQLLEVQKKLMEDPLFIKAINNIYSENSIQFLNFFKIHPRTVFPILFKRAQNLGIELREKRIEQLRASFLKRKTKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPN0</accession>
    <name>A0A9Q0LPN0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abelson interacting protein isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPN0"/>
    <dbReference type="OrthoDB" id="10622943at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="313" mass="34906" checksum="8C55725EEAAD31C9" modified="2023-09-13" version="1">MNLSEQLDNYINGLLPTSLAELKQSSQQLDKIAQISIGEYKTNPDETKMKTQNAVNEGLQTVAQHIFAVSTHLNNLLTLQDKQVEKLDLEIRSALARIKGAHIRVGQAGLQKLYKERIPIEGEKTHKLTEEQIQAEYKQKTLINIKGYNINFEALDNIGISLSNPNQESNTIKMKNKSENPIQEAIIKSSERKEEEKTETETETETDESISKPKSTENTSKTSLAIENKSPPILPQRTSSLPQPPIQNTQNPSFDNIPPPIGDDFPPPIDDLPPPIDNIPLPIGDDFGLMPPPINDDFPPPIDDIPPPFDDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQK1</accession>
    <name>A0A9Q0LQK1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQK1"/>
    <dbReference type="OrthoDB" id="409642at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="125" mass="15043" checksum="6E0293EFB3AB621F" modified="2023-09-13" version="1">MGFIESKPKIVLIHNENQNQIQNQIQLENQNQNQNQEIQSEIKKFNKFLIKQANKQIGLISEIVKPILKFFYNGKFEFDKQKFDEYFQFANEIKLKEIKIKIELEIQSIFTIENILEIYFKISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR01</accession>
    <name>A0A9Q0LR01_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="CEENDEY"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2148"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2151"/>
            <end position="2181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2440" mass="291710" checksum="588C73159B8F4A37" modified="2023-09-13" version="1">MEQKDKYLHVYVYVKLTDSNIIPIIETKTKELEMIKVEENSHVWFSCWLFNPLPKTNYFFDIKIPSFRKKGFVFNNSESQSDHAFYFITKQKLNQDILIDFLNAIIQKEVVPENNLINIRFKLYYQAIQEFRKKFFKPKKIRFNEFIYVVLDRFFKSLPFDAKTKHPYSYLLAHFFLMMYCSSFDFQFFYKISGSDFLPKFFGVIQDFSKEENTYLKEMREFFFSFFEKILYNVGDSYIVSIFVFLIKSQSINNTKKFEMLDERKVLDQLIVFFLKEPEPDDFFYTLLKLFDERVYLHSQKLTKLFFEHLAVDSKLLRVFIYKNLRIPLFQLIPKFNFDSFIDFCLFWSQIYKKVKQLINENNENIQINENNENNENNQINENNQINENNENNQNNQNNENNKNIQNNENNENNQNNQNNENNENNENNENNENNQNIQNNENNENIRNFLSLMKEVIITSFRTQFSPKYTPREWILHFQDTKLFLYVDQYPYFLRKFLLEFLNEKAENLDTESIQFDEKNHLKQLSRNLQIQLWDLFVKKFKEKNPNSVDYFLKYLELKERKHPYWILLFKWIEQIDNKIILFQYYEEVRNYKKNIMEFVSKTESLNLSFLQLQSIIQNSHFYLTIWEIANKNFQDIEAKYNQFSEKKDCFKWLRENVPFDEVNQEKIDNITFIFDYGSQNTQELIASMEKLEIAEKYSLKELENQIQTSSFDESVLKNIFYLQKNKISQSLLLLEFLPIMINNPPVSIHDFQDKLSSFLQEKINLESIFTKEITFQRLNNLFNKIENQDIQSSLTSLINFLNKEKKPENQITEIVKQIISYKEYKKKMESLWNETVYFFSCFKFSFERYSNFFSNFWQNQRQLQELPNLSQILEEALYAQQNLFSSDTYLYIFYQLVTIFSQFKVEQDFAVFLQSLNYSEYIIQQISSFRNIIKDVVYSASPFESFSSLVKSLLLKKNINFMSHFENLVKITPQISNLVNKNWVSIKKVIIRKLSLIFKDHNFNLIFNYFPRKITSFICTLNEKDLTEYTFSNFSQIYRICNILDFSQESSSIQLFIKSFQQIFPIIDQISQICKQLKKSYYIDFANIYESIIEYEFTDKIDQFLTKLAQQKQKLNRKLEEWDNEVSQISSQYLIFSIFSKEQFFFIANEFLNIHNPIPSSQLLYLFSCAFSDIHIPKIMQFKKLLLFQNLKKLNLTSFVQLLDSVFKIDKLSQSTKSRIVSVENPISKNSQKYNFIKNMFKKAQNNTQFFPLRENVLICDSQSTTRSDIEKFFSVYQIYNTKSQKGNFLFSVLHAEKLSKQCLEFFIQKLREIKHKIHFSMIIFYHENILGTFPLVYHFPNFPVKNSMETFSKEKFQSIFQKDQTRSKNIQIFTSKYSKMGKSTQIHSLFLEKSLQDHQLIYINIFLSEGSPYELITKMNRFANNQNAHYFFHIELPLHPKLETFDFLWTLSMWNLVENKRDSSQNSIWKLSQSNFIAFEIPNKIQTSQEIDILMNFSALKYFTLNQSDNSYQDSSTQNIIIHQILQNKDKQKEKINQLNQLIKLINNQNGNNENNNAQLHQERNTIFSFFQQKISHHLKEHPLTPKILSDFYSLLFYQLDLPFFSHLILVPNKIKEYFQNEEILNEFMSPFLNAYLDSLINIAITQPNFLKIQENPQFKKIQDIFSVLKEINEWKSRKLCFVAPFLISKTFFKIFLIGDCTDFLSKIPQNVQDFLLQKEMLTIFTTSQKEICEISENDIFSVFGALHKGFMQIRTEKSRIFEKNKESLFLTNYDLAKIVHLQFRLLAKLPVIFYFRQTYEKRVLIRYFFEEILNQKLLFYHVHPQFKKIEMVKILREAEKIATRNKNSQLNILFYNFHQAPKSLTFSFKEILFTHSFNAKKLPENLRFLASINYFENNPKNPNQEQIQYIKQIPQSFLDEMYDFGDFDQEERKSYLLLMITQTLQKKIQFPEPFTKTEVKTLCENISDTIVNLEENLIANFKSKYNSSRLLQNASNFLIIFQWLVQSEIGKVLIKKKQTQDLISSALLLSLYLVYSSKFKQNYKSVLFQKIQPLINPYMQNKILDTSSKKEYQQIIEKIIQNLLSFLGVNLSKTHICTNSNLKENLLFIFIACMTGTSLMIIGSSGTSKSTALQIILDACKPRNENENQNQNQNQNQNQNQNQNQNQNQNQIQNQNQNQNQIQIQNQNQNQIQNQIEMKKIEMKKIEIACSIAISANNILDELKNIQKEYERIQNSIIPVIILKNFHILKKESLTILQSEIGELFNNFKPFYQQKDIFAPSIILITNTIIDFEIPGITLIHDPINKNELKSTTKKILDSFSQQIANEYDRYVTYFHKIIANQNQFVSEQFKSISQNIELKNKFYGNQDYYYFLKDIGFNFIRNKKTDFLNVFYKYLFVNFGIEKKSLEDFFPKLKSKTSVNIPESEFIKSSSRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT51</accession>
    <name>A0A9Q0LT51_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT51"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="41"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="161" mass="19580" checksum="1B16C4CE05E30A32" modified="2023-09-13" version="1">MIYSNNSKINPKLYYEIKEIINSNEKIEETMKRIYYNENEKDFIIERKEKNFRFHKLILIMRSELYRRMFLSVTNDTSNKVTDYSELSNKSFEIFEYWIYSNQIKDGIPITQEIATEFQQGIGYFQLNQTNPNLFDLLIKKFNNQNYIQNQKIKNKDCSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT91</accession>
    <name>A0A9Q0LT91_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT91"/>
    <dbReference type="OrthoDB" id="10256467at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="165" mass="19109" checksum="852A522084F62F9D" modified="2023-09-13" version="1">MKRGFSAKKEGFDCKKWYEICENKGKTLIIIKTEDDYIFGGFTSVGFTNDKTKWLPNNTNLNYSYIEDPNAFLFSLINERKYPEKFTIKPELSQLAIYYYRANQGPSFGGGNDIHLNCDLRSGFTFFGNTYNLPDGIKPNTNEAKIYLAGSYNQWKVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU91</accession>
    <name>A0A9Q0LU91_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_14577</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="JAPDFW010000036">
        <property type="protein sequence ID" value="KAJ5079143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU91"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="506"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="702"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="1175"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1012"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1120"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1022"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1034"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1138"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5079143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1274" mass="148067" checksum="BA3C2526EC9DC2BD" modified="2023-09-13" version="1">MEDKNLNSFPFKKNKTTNSNQNFYQNPNINQYKQRLNFDSPNQNQFSLSNFDSYTHILMNLYEESKFLEREALKFHLKIENFSQKIQDYLSRALEQDYESPLQKSQNLNSSNQNFTTCQVNSRYFEPNNSNQLENEIQLENLIQLENQIQNPIQLENSIQNLIQNPIQNPIQNPIQNSIQNSIQNPIQNPIQNPIQNSFDYRNKFQSTDANLELSDQSDLDLFNNPYNEDSDDFSNEIKNENGKIQKIQEIQEHFQNSNEIPSYNQNSFKQNNISIQNQSNQSNIQENSSNFNFPKNEDKFIELKDEKQNQNPSNFQMNEKNNEQTKIENNEIGINQNEGLRGLDLGLDLDLDLDFAQFTSNENPNENENPIQNENENQNENPIQKETEKPKSFQNQNENEKETEKPKSFQNQKQNENQNQNLNQNENSNHKDKSKKIEFPKEKTSKRSSVIKHLYPKEIQGTDVTDPEPINFYSQTNFPWSERVDIAKEHQFEIEKFHPNQLPAINAAMDGQNVFVLFPTGGGKSLCYQIIGICKDGVSIIISPLISLIYDQVKILESLEIRVASLDSDMKSEQQEQVYAGLKKQPEPEFKFVFVTPERVTKQRFRSVLRNLMKRNMISQFVIDEVHCVSQWGHDFRLDYKELSLLQDEFPSVPLMLMTATATKTVRKDIYKMLKIEKCLFFKNSLNRPNLMYLVEKKEKNVDDQIVEFLQEKKLMNQTGIIYCYRIKECEELTEQLKAKNIKCETYHANAKEKTQVQEKWMNGTINIIIATIAFGMGINKGDVRFVIHASVPKSLEGYYQQSGRAGRDGKKSFCLLFYSRKDKNTIDNKSNQSSASPDQLAHYRNLLKSIVDYCEDNQTCRRKLMLDYFNENFDVKNCGKTCDNCIRTAKSKFTETDVTPHVQKILQVINSVPTNVRQSSLIHMIRGTGRKELERRRCFNEELFGFAKGVYTEDEAKRLVAILIQKSVLEETYQEIQSQYRKFGVFLVPSKNANDVINGKLKIKFNFVEREKKRKKASPKKVEFGDLDEHVKKAKTKSKSKSKPKPKSKSKSKSKSKSKSKSKSNSNSNSKKNPDSDSDSDSNSDLNSNPNLIINQMQSTPQNNQMDISNGYLRKTKSTLIPRKKADPKLINPNLKSNQNQKSNQNQKSNQNQKSNQNQQRNIQKEEEPKKRLNLDLYLLESLFELRRELAEKEQKPFHFIAQNSVLSNLVLKKPTNINDLKTIPGLDHVIIRKFGNAFIQQIRQALGLNPSTIQFQNQKNQDTENCKFDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUR7</accession>
    <name>A0A9Q0LUR7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAPVD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUR7"/>
    <dbReference type="OMA" id="CDRINGW"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="6">
        <location>
            <begin position="153"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="7">
        <location>
            <begin position="730"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="879" mass="101805" checksum="0277DF90C2F8ADCA" modified="2023-09-13" version="1">MHHNTRRVLNSGDELLKLQEILKREKYCLEAEQNALETIRQQSEKLLEDLQSGVVELINMSRLMETLSVGNIEYKLKREEKITQNWKVQIYDPFESPLSSVQKGKYQKMMQMIRENLDVLALSMSDTRNLNRTCTETLSHSAIFAVFGHLFSFNEEMNLLKLLKKLIELQIQQNPNVKELLTGNKLLARLLSAYSKTGRSNAYLISSLRSPMLDVIQDLNLDLLSATTNKQIDKDGVMTRRLIFYAKEFLGSLHDKIKLIPYGIRWICKFISEICKQNKLEKDMVHVVGDFFFLKYVNPVILSPGKKEFLEKRYGVVSDVPILKKSRFNLTQIAKILLSLCHGTSSLRTSDAMFGNKIDEFDINMKSFINDLINVPEKIVSDTTQDNFILESFPNAKNSLVTPNDLYALHSLLYEFATMVLPEKQNVNEILQNPLIQFMISFGKPPDFITETEMKYLPISLGTKPKTTEKKKVVQESKSFSQRRKTFGISELGGETKFSRRKTTNLHSFQAAFPSQNDDIMNEAERKLRQVLCKIDYFVGKKGKSFIDILLEEKEAAHASHSIDLACLLDSTIQTLEKMPLSVKKAEYRPLIWKIKKEHETRQNYLKDLIEKKYNFQHTMNQLQVEIDQIQSQIMTFDQYMNCLATNLLIEKNQDKINKVIQDLKSAFDINDLEKKISEFYTSLQQIISSDSLCSYLRSMNPLLKIAENYAYIDIYSVMFQPRFMRQEMEKEDTTFSIKNVTIKHKMTPDFLGVPEDFWDQSMWFLAIKELSSVNTVKSPLLKIECLAHCAQVVNNILLFNGISEIGADLMLPIIIYVIAISNPPNLPSNIKFIDMFCDRDVIDPEYEYWFTVFKSAYLYLSELDLQTLPKKKVLYKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUY2</accession>
    <name>A0A9Q0LUY2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P53 and DNA damage-regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000010">
        <property type="protein sequence ID" value="KAJ5080466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUY2"/>
    <dbReference type="OMA" id="DEKAMVC"/>
    <dbReference type="OrthoDB" id="20282at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22860">
        <property type="entry name" value="PDRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030482">
        <property type="entry name" value="PDRG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162:SF0">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="125" mass="15133" checksum="787956848FA5D7A4" modified="2023-09-13" version="1">MTDFENLQKKLIQMELLAEEILVEKHTLIEFDKKRQSNRESLDIIQHQSEKIKNKKIWLCLGEFFIKVPKENAKEYIKKDQKNFNQEIKRLQESIKEKSDELYKMQGDENKMKGFFLKPINKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVJ1</accession>
    <name>A0A9Q0LVJ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional activator hac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000052">
        <property type="protein sequence ID" value="KAJ5078645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVJ1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="372"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="473" mass="56953" checksum="D9288FD6FA8C6109" modified="2023-09-13" version="1">MSKNQNNLNKNLIKSQQEFKSNHFQNSKTEELNDSFLIKHENNLIENFKQNLIENLKENEIENLKENEIQNEIENEIENEIENEIENEIQNEIQNENERSKFFQEDFEEIENSENQIVENQTIFDDIENSTQMTPNNKNLQTESFIPKNSPLELDFQSKNSTEKLQDFQSKILNENYQSKNYEKFQQKIFPNFQAQNFQFQPQLYDQDKPKQNQYSHLQKKPQNFNLQSDNYSAQYSEQFTQQFPQDQNEDQDEIQKEIQKEIQKNIQNELHLQQIQNLEKENEENQNENQNENQNENQNENQNENQNENISTKTKKKKQKPKKKRKSQKDKKSKKEDKKENFDEWITNSRGETINLGGVLSKEDVRELTQEQKRRRRMLKNRRSAKESRERTKNMIKNLQNEVDKLRTENAELKETIKKLNEKNSYVRDFPNRQSNERAKNNLNDFSWSFYNQKSIFNDISTQDSSNPFGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVN6</accession>
    <name>A0A9Q0LVN6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000048">
        <property type="protein sequence ID" value="KAJ5078705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVN6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="467"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="576" mass="67506" checksum="E78443A9138DA03F" modified="2023-09-13" version="1">MNESLFFGLNKERKLFKNELEKITKPIQFKFENENENENENENENENEKQIKQILISEFSTIFLFKNGKAIEYPHENDSKQNPSKIQIENIQKVTAGIRNVSILTKEGNVFAKGKDIIRKHRKEFINISSLIEDKNDRIIEDIVSGLNAIYLLTSNQNVYGIGSNGWGQLVIDSKTLKKTEKPILIMKNVSKIFSGNDSLRAFFLNSNQELFGCGDNRFGQLGLRKSRKEALTEKLTKIQNIPKGKIIDIQCGYSHSIMLIENENENSKRKLYSCGYHENNGLGKNEDTYEFTEIKSSLFENDDNILDFSVGSNHTLILTTKEKMIGFGNNSHDISNYHVSCGYYNSFLYYSSPSFSNLEEDLIKLFEKKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNENQIEKLQEIISNKSIQESNQIFEMIYSNRIINPELYYEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTDDTSNKVRDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIIDELETGIDYFQLNQTNPNLFDLLVRKFNNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVN9</accession>
    <name>A0A9Q0LVN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000021">
        <property type="protein sequence ID" value="KAJ5079923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1467"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1571"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1635"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1667"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1875"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1875"/>
            <end position="1899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1937" mass="219876" checksum="37B079CD16306BBB" modified="2023-09-13" version="1">MILDFYNFPKSNNVSFYQPFTSELRVSKKFKSDGMDNCTITASGASFEDVKMLGKTDLTLLEEISSVQSQIQLYGNLTATSDNDGIATFDNIQVIYGPSDTIRLIFSVVCESESELSPTGPAKSLITPLDNKTAITSYPLFVDTDVELLSLYNQSEVDSILDYFTLNNITFVVNSSNPDLRDVKIIPSVVRNWSYPEYEAFAYFNTQYPILNVDDDNFTTIYFNVSGSTTRDILFTAFCEGVEIDAPFNLKFNTTVSSITITNPQIKNGEKYYVEEGKNFTDPFIIKIEDSGGKGIAEKPVFAKIAMNCDYNISEYQKPLFNSKSLLNTIAITNSSGFANFSDLKFSVDGKTNSQCAFQIEFTSDGIYIITDNIYVNSSVKQIIPVDIVKNITISNTYILEANPRPLIQVLNENGTGIPGKYIEFHFGEVFWDQQAVQTDINGFGIFDIEYAWMSSLNGTYDLIIKVDDQNITMPNVTLILNFTEAPEYCSAINITNWNISVNSGDILNISFEILEFYGNLSSNSSDTFTLTAYIDEGELPMGYVILNDSIINNNFPETGNISIPIFGIQMTTMFCLQAKKNGLKPGDFDTCEGCYLMDLNNPIKTASVIEYNKTIHKGESWNNSTLTIEYELYENQSLNNTVTIHILLQSYFPESFDYQNVFNGTMDINIVYNTSTILYEFQVPVDNNSNLVHLEGFQINYCGTYNMAIFINGFPSSEISIQVIPPVTDFILTIDWNPGIVKSGYNKSIPSALVQANFSDGSLAKGYYIYAQSEDDDCTLLFDYDDLEQVGLIQSKTPLNSTGYTPLPLNFLFANNTSCNITFCIFGMNNSCDESSKKNFNISFEIDQYQIESFDIDHLLYYNQTPPIPPKVSVTDSSNVPQGNKSVFAMSIYKVLIDYAITDQNGTAIFNNFRLTEETDVLFVCDKSYSSIINFQVTREPTLLTVLTNPLETGAKIGIPFPLPHVPCFFQKDPYLGSAVVGLYFQSTPIPKRPIFAMINSNNGDGSLEEYSSVALTDNNGIAVFDFIMDSGSSGNYTIEFSYNDLRSETDPFYVSNPVTSVSTNYPKKKFNIGIGRQFPVHIQVNFDGSQKSKRVPIQILSQCSDASIVNSIPFTNENGECDITVQFDASSGDSSCLDEKDKVKASIAFSAYGIQSKYENFLIDAIDNVDLEAAKDSLNQSGIFWVICFTLAIPFILNSSRNHHILTYIVALILAAVLIAFLPQLIPKTDSTYPMQYVFLAVLEGVLVSFALLFILVIVVSKIFKKLKFYIENRSFINDRVSSYMLLFKRLLPLGAKRHLKILEMERKLIEDEISDSDSTTDNDDSDEKPKDNVGYIEEFELEAQGDDPLLDNDSDSSKSNQKITSKSVKEKSYEELTEREIGLILRRSVKNLELKRLSDAKAAGKTIPIEKKPKKKTDKFKRCWRGFVNLLKKIIKKIKEKFAKEDNPHEQYETYYDFYYPQRLLTAFWLWVIMSAILVLLITQLFRSITLSILWYRQEEIGKIQQSNCFDNKPVLSDYPPTSLSAGAALLIKSIDKQCNEDISALGNIWAEFIKKIPPDMISKVCNAFSVIMGIASFLAFIIMCVQWRSIFKLYRKRIMILRQGKTPFEEYEETDVSEVTSFTNLQIWLGLIAYVLAWLVTFFVLLVIPAVIWLMLYFLTKAILLRILLVIFIIILVVIFYQFVIIYLVQKLVKTYFIDDNTIMNRTVFSIYDFIKFFISIFSSATDAAKRLIGASGVSVSYSLFRLDLEGSMDSSYSAMMKIDHQTNNPILRVFMNYMMNYLIHLRKEIQKIHKNTFDITNEEISMTLSYFDHHPVTGEESRKEKLRRRFILLLTLATNKSLRKRGIIIRKTKRKKKALKKKEEKIWMMISKEERMQKPKKEEIKKEKNSDSKSSELGFDELSSDNDNKDKDLKIFKNDLKTPLVEKNNSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW34</accession>
    <name>A0A9Q0LW34_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptor 157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000015">
        <property type="protein sequence ID" value="KAJ5080057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW34"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5080057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="276" mass="32159" checksum="FD28960183127794" modified="2023-09-13" version="1">MVSGEEIATIIGAGLGLIGALLIIIIFLYFKENKLFYRKLVFILSIYDLLESITYLLPGNSEKILCKIQYYLIAIFTTTPQFWSATISFISYLKVVKEFDDKKLNKIHKWFHLIMIIPIIVLIIIVGYSHDYNKSKTYWCTSTNEAFIIIIKFISKEFSSTTRINQMNQIWIQIRMSLIPLIEILIAIPPTIRRLREIIKPSASDIPTLDFVHSLLASSQGFWDFWIFIVFDPEMRKKTKNCFCCSTSTKLNKFQDLEPININDQLIKKKEIFNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW76</accession>
    <name>A0A9Q0LW76_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Granulysin related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW76"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040190553" evidence="2">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="23801" checksum="EE34BBD65DFC755F" modified="2023-09-13" version="1">MKELSIFLLIFCVFFSFSKSEIQEKPTQKSISICNHLANYIKKSFINDKNIESLNLISYCEEKFPSEFIKECQNISNKYSKKMIQKITENEDPCTVCPLNTIESENELDLNDEKQNFSFEISQKHFCHFCLEITQSLRTLISEQSQKKSLTQRSMGRLCDLFTDQETSFVCQAFIKTKLESVLEKIFIDLNPENICKKYELCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWA0</accession>
    <name>A0A9Q0LWA0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWA0"/>
    <dbReference type="OMA" id="IHKRVIH"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000004">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="5">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="121" mass="13804" checksum="60703C539DF66850" modified="2023-09-13" version="1">MEDIKKQKEKDTATPEKTHHIRVTLNGTDVKTIEKVCTDLVQDGKQKGLQVKGPVRMPTKRLSITTRKTPCGNGTNTWDRYEMRIHKRIIDFYSPTSIVKQLTKITIKPGIDVEVTILESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWX7</accession>
    <name>A0A9Q0LWX7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWX7"/>
    <dbReference type="OrthoDB" id="10029846at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26598" checksum="F663605EF7151BBC" modified="2023-09-13" version="1">MISQLGVPKILSKSSSRYLSPFYREITRYGTRIRSRERNYLPRANSYGMQTFDNKEFFQTQCIYPYNVVILTSTKMLNHLSGARQLFLDETFRVAPTGFKQFIVIRARNNDTNMFLPVLYGVMQTKELNNYLEFFSLLQFITPRIETEFITIDFEINLKTSMDSKKEKKSLLLVLFFIGIKDGILHLRSKSKQLKCIWILIKIFFGNYSKIGDHFGVSFQTIKNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWX9</accession>
    <name>A0A9Q0LWX9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000012">
        <property type="protein sequence ID" value="KAJ5080146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWX9"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="480" mass="56846" checksum="E6375FA58B35CD62" modified="2023-09-13" version="1">MKIKILSQTKTITLEEQEFIKKILSLDSNSQEFIQILNEKFPFKEIDIFGWIEVLNKFDEIFEKEKLKESFIENLTNIEQFNKELIIGVLKFTKQILKKSKTHIGIYNSEEYIKRLLDIGEPFADYVLELVKVLYSKISPSNSNFSAQFSKNPSFTKIWQNELFSSLFTYSQISLITNEVHKFTFLDFAKIDENLKMQKELITDSSLMNFSFVIKKEEEKDQEKLLQQIQLNFSNWFSEIDELKNLSETQNLPEYFFPIIHQYYNRFKSFQKGVDGMKQNFKTKLIAFETLFSISSQNNPYIKQISKNYPDLVQELYSLALTDYKIENDLRFLSIQILMSIYRHAFLQAEIIEKAGFTSRIEVIDTKTIPGLMEYLMADLEDQLKEDPIYNFRFLKKLSKFILMITKTPNAILLFTNESQWILGTINLIKDENPEILPIITNFIEIWFFLLNRNTNAVPMIFYLKEIFIQMSLKELKQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX07</accession>
    <name>A0A9Q0LX07_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(+) ADP-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_04461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.30" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX07"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="249"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5079440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="474" mass="54494" checksum="0EECCF87D6F90364" modified="2023-09-13" version="1">MSLCEAVKDGNIESVKKLINGGADVNERDDKQMTPLHHAAGNDDLIDILDLLLEKNADPNLMDEDENTPLHKAAFRGNLEAILSLQKYGAKQSPNRLNRKPEDLASRFRHEKCLDALTKPGTIQSERKPEPPQTETKEEETKSNENEEKNENAGNENSGKIENPAKNENAQKNQNVQKNQNVQKNQNQMQNQMQNQMQNQGFPMQNSPFQQIIYPQNVQSQFLEVPKQKPLRYKPGKISRLNKKPLFKWDLKDVADWVYSLGLEECVENFVRNHITGSELPFLTEEILEKRLKIESYGARRRLAERTALLHANNIRLDIMNTHIPHPEPQIIEPENLIENQLENLIGNQLENQFGNQFGNQLENTKSINLFCYVQKSEIPNKYFQQNQPNSSVQKIFIQIHLDSASISLFKTKLSKKLEILPSQIGRVVTEAEPHIFIIDDDDILMLKDKQYLAIEITKIPKEKGKKKKTNDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX34</accession>
    <name>A0A9Q0LX34_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX34"/>
    <dbReference type="OrthoDB" id="10689425at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="70637" checksum="5AB1339E1C98417B" modified="2023-09-13" version="1">MKRNIFGSLQINSPSPLTQTPKQKSNQPKEPSIHQLLSSIQSNFAQERAEFNLDLISSERQFSATILCLTTTGFEILSEDKKETLLLITFKDFPQMNMNFSRDNELLLRLAINNEKCLVLRAQDTHQRHIILKTFYLFKTYQTDLENINQDSFKSIGNCLSIHDELEALSQRCAHQNKISFLLDSNFSKDEEKYMSLIEMTNEQIQVKKLSDSSISFFLWNDQITCSLLISKPTELIINLGLIKLYINCQTEFIRELFFRCFQVFHQPKPNLKLPIFFKQEEVIYGLSIPTLLQKPQNEVLDMESLKKNLPEDPILDLPKNIDHFNFKAKFIENEENDSIQQNCFLSFSKHCLSFFSHSIFSINFLKNIKVLRNSKKSNVGRIQFDKNRFFIVKFKNENELNSFSKHLKVISQISSFKEDQQAQKKMKFFPFEITENLVNGTLILMNNEMKIVYPNNLYLIDYNQIDKLQFDKNSPTKIRFLIEHESFILNFLENQIAELSTILLKKKEKEKEFIVNISFGETQRNGKIQFTKEGIIIIYPEQEQKDNFKITEKTKIFYDQSQPKFKIEFEEITLFVNFDSIILANSFLKKFLSLKKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXX7</accession>
    <name>A0A9Q0LXX7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000005">
        <property type="protein sequence ID" value="KAJ5080644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXX7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="321" mass="37219" checksum="B4CC255BD51177E4" modified="2023-09-13" version="1">MSYRKNQYNEYSQKTKSFSKNQQNIKEFNNRKFVISSANSKFKFIKRLGFKFKIHFNSNLNLNRNSNINDWDSNSNSNLNLNRNSNINDWDSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNNYKEEDLWDSKIYLVPVENNKEYNWDSTPNLYSKPEIKEIKEIKEIKEIKQEIKESNPKKVTKHVWIRNKKANIPHYATGGNRARLGRLNPEFIKHDEISEKDEKSIDNLADFLLDFSINKKNENHLEYAIQEQQYRQNLRTFHPKSKSKSKFKKSKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXY2</accession>
    <name>A0A9Q0LXY2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000005">
        <property type="protein sequence ID" value="KAJ5080656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXY2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="354" mass="40292" checksum="67960B541617307E" modified="2023-09-13" version="1">MEFEDFSVEELTTIVIDNGSGSTKIGFSGENSPRSIFPSIVGRPRFSGMVGMGQKDSYVGDEAFSKRGILRIKFPIEHGIVINWDDMEKIWHHGFYNELRVAPEEHPVLVTENFLNPKSNREKITEIMFETFSVPGFNLEKQAVLSLISTGRSIGIVIEIGDGVIQIVPIYERFVLPNSSSKLNLAGRDLNEYLMKILNERGYPFTTSAERQIVRDIKEKHCYVALDFDKEMNEEQTLIEKDYELPDNQVITFGNERFRTPEVLFQPSFIGMQESGIHQKTFDSIMKCDEEIRNDLFSNIVLSGGSSMFPGIKQRLKKEIIQLSENKENKIKVIALSERKYSVWIGGSMLASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZ45</accession>
    <name>A0A9Q0LZ45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tumor suppressor p53-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000020">
        <property type="protein sequence ID" value="KAJ5079940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZ45"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="344"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="538" mass="62246" checksum="E12FF08EEACC1FFF" modified="2023-09-13" version="1">MNVQIDPILFKAIKITQKQTQTTNQNNNKNNNKNNNKNKNNNKNKNKNENENYILNNFETSQQEKEEEKSSLINIKKSSSATIKKPSSITPEKSSKTNQTKKNKSKNSKQKFDQKIPIDQVDEIEKFDEIEKFDENFDQIDLKSKTNKSNARKDRKTNKKTNKKTNKKKKNENEPEKENKKRKKKSVYDGAFCTFCESKETSQWRRIPKWYRQNISGNWLCNSCYSYLVYHGELHHRKTKQIAPTKKQNPQEDNTVMEVDSNTSTDTDTPPHSNLNSGEKEKLVDENQKNFKENQKENSNSIENNQLISNEDPALSPNSNDKSNMQEDTVSVFTEETTIFRQKNIPSLFGNMKFFLVSKSFSQNSTQKEVLKTLKKSTTQLIETYGGEICGASELINAPQHEDINVISLSDFLPKNPEQLKSNFSVLVALAKGIPILKGAWINQSIEKRSVLPKRDFLLSKSTKQIAYQNRVFFGKQIFLKGSFDWKNFWSKVFTCSGAIITDNYDQTDYFFLESPNFSNFDSKEKILSIEKFIGFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZN4</accession>
    <name>A0A9Q0LZN4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZN4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040281960" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="418"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="874" mass="96774" checksum="C433F0BFD6069F5C" modified="2023-09-13" version="1">MKKFKIILIFFLISLISAQKTTFHSQNEISLWNLTRTITPPITTTTQFGSKVKIFQDIAVISDQTEVYIYRNNGTNFNFEQNVSQPISKFGYSFSVSKNVLVIGTYDLNQVFIYSFNGSYWNLNQILNQTSGFFGSSVSISEDFIAVGAPNSSQVFIYSFNGSYWNLNQILNQSSVNFRYSVSISGNVLTVGAPDSNQVFIYSFNGSYWNLNQIVNKEIIQGANFGYSVSSSEDFIAIGAFGTNQVFIYSFNGSYWNLNQTLNQSSGNFGYSVSISGNSLVIGTDNSNQSFIYSFNGSYWNLNQTLNQSSVFVYQLPLPQVSLINCSSLFSSFECYWNQAYFLDVLEYQINYGFGWKEIQSPVVEQGNVLYQQFNTSLYSNITGNTNYSIQIRVCIESSSFDCGESSSAIALKTKIGSVANFKLTPLSESINISWAFPNVQVVNGIPELDHYVISYQNQSSTTLTTFSVSNSSTFFILNTLECEVDYNISIWACGNSLCEVDEKGEAISSSISGILAKVSNFVCSITEVLDLICSWDAPVNCSGIISSYNFTYRAISRNDSFSSRINSTNKTVKAHFQNETYQIMVSPCDSNNICGEISTATLQTGNLSAPAIYQSISKIEEIEINFQNLTQAENYILSLDNQSHWENFSSIKTNGNGTIVGTKTALSGNVEYQVSLRGCLDQNCEPNYLGFASSTFSIKPKLGNITSLICVGLISGFNCSWDSLKLSEGLKGYSFSYNSSSVCLSNSTTNFSVSGLKEEEYYEISVSASAEENCSQSEYSGINSSIFVKTLSPSPSPSPSPTPIHTEDAKSSKTTKIVIATVVPIVLIIIIIVIVFIVKKRKNSFKGIKIDDQDLEFEKDLEDSHQTKLNPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0M028</accession>
    <name>A0A9Q0M028_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromodomain-helicase-DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_13969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000007">
        <property type="protein sequence ID" value="KAJ5080588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="VEGENRM"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="409"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="512"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="616"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="922"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1301"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1495"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1301"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1348"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1495"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1513"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1523"/>
            <end position="1561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5080588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1561" mass="185180" checksum="90E9204F01376C3C" modified="2023-09-13" version="1">MNYRMNYQMKLSNEISNEISNELSNELSNELSNEKKSKKQDFLIESESSDFTEDSTEMKVEEELNSFRYQPIFANNQIEMELGTRTGLRKKVKRLEQYVFYPISDDTSKSESESESLSKSESESESESESKSKSKSKLKSKSKSKSKSKSNSNSKSKSKSKSKSKSKSKSKSKSKSKSKSNSNSNSNSNSNSNSESSDVDSDESDNQEAYKEIDKILTKRSLKEKKKQELLNSQKNYPQLNEPESFPLQNQNSLENENENQNENQNKNQNQNSLENQNQNQNQNQNQNQNQNQNQNQKNQNQNQNSKKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNPLENQNQNQNSLENENQNKNKNKNQIKIEVENQIQKEIEIEIEKEIKKEIKEKKRKKKKKKNKSDSESDSESESESESEPESDEDEYEYLVKWKNYSYQDAEWVTEKIILEKDGKQRLKYFNEVTWPSMTDEERIEPFNPEYVEVDRIIDMNEYKNKEGKKCIEYYVKWKALPYSEATWENEPDIHNTEEIALYHKRNSNLKLKQQNLEELSKKFPVTHWEKIEKAEEFNDGRILRDYQLDGLNWLTFCWYNEMNVILADEMGLGKTIQTIALFDYLAKVQKISGPFLVVAPLSTVTQWQREVESLTDLNCIIFHGTKESRKTIEDLEFYYLDEDDEIIETEVYKFDIMITTFEMISSDKRIKKIEWEYLVVDEGHRLKNRKTQIRKQLLEITTANKLLLTGTPLQNNVEELWSLLDFLEREKFGTCANFMKKFGDLKSNQEVEELHKIINPYILRRLKEDVEKGIAPKEEKIIHVQLTSLQSKYYRAIYEKNYEFLVKSKAVPKLLNIVMELRKLCQHPFLINGVKKYLKKKFENTEKKDKLLVECSGKFILLDKLLPKLQNQGHKVLIFSQMIKVLNLIEEFIISRHYSFERIDGNIRGIERQSAIDRFSNPKYGRFIFLLCTRAGGLGLNLTSADTVIIFDSDWNPQNDIQAQARSHRIGQKKSVIVYRLITSGTYEGQMFELASKKLGLEQAILTNIQKSQKKLERKEVEELLKCGAYAALNANSEEAQKFGEESIDQILERRTVSLDDFHENHKASYSSASFVSDSSEKFWEKFKPIGEEKEKGKKKRRKFRRKSFAVKKRNLRKINQRNKKTKIIEDDNDDNDDDYKDINEDNWYFAERDRLIDGLLTFGVSRLLKIRNESKLRRHEFPNVQKFTLTLLSFCISKLASFELFIKYPILLQILFELCVEEYLDDLQQKKLQEEKLKRENEKMKESGKSKRENEFEKTKINEINEKNEKTEINEKMDQDSNKNNEDEDDEDEDDEDGTKEAKSALLKIQQENQPYQTEEKDTIFKSLINQIVFDDQEYQNKLKENSFLAKDAFINFEVDEFYSKKMALFVSYFSSDSSHYIFDNSLLRYEFLTSIENEFKVWLKKLEYLETLSQIIILVVWRNYEKKMQERQEKKERRKKKEEEKEEERRKKKEEKRKKKEDEKKKEDEKKKEDEKNKEDEKKKEDEKKKEDEKNERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4G9</accession>
    <name>A0A9Q0R4G9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyamine-modulated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_03346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5067002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4G9"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="75"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5067002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="22993" checksum="3D39BE9BA7F71E03" modified="2023-09-13" version="1">METDKTINGIRNKKLFEVLKFTLKKITKSTEKEKFISQFPNLSKKNGELLEDIFSQFLNILENNTINEFELIYEERNLQDTLNQLEKMIEENKEKPIKKNQIKQEISNEKVKEVISKREQLEDQQKSLQDELLLLEKEKESLGNEIFQLKKEVEEIESKNEKKSNEKEKEMNETLLNLDNFLNQLIKTTNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R583</accession>
    <name>A0A9Q0R583_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R583"/>
    <dbReference type="OMA" id="CINDSNA"/>
    <dbReference type="OrthoDB" id="2160519at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="105"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="283" mass="33227" checksum="392FCC03CC9EB02A" modified="2023-09-13" version="1">MNEKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIENKEKEIEDKWKKEVEKMKPVFDEYEKEFKEIQKKLEPIRKNFPQFSETRIITEEEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKRETLVIIKTKQNFIFGGFTQVGFKHSQSGGCINDSNAFIFSLRNDKGDRIPAKFTYKNDGYAIHSGLSYGPTFGYEGNPDFGFNSNLKVGYSNFGNSYNLPNGITYESNEAKSYLAGSYKSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5I3</accession>
    <name>A0A9Q0R5I3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear fragile x mental retardation protein interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5I3"/>
    <dbReference type="OMA" id="KEITEWI"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1238" mass="145043" checksum="E20F5A5BCB2A45EF" modified="2023-09-13" version="1">MSSKSNSESDNESESESDNNSDSYSDSESESDSNNNKQNQIQNQKQIQKKNQNQKQNQKKNQNQKQIQSESESDSDSESESESESDSESESDSDSNNNKQNQNQKQIQKQIQKKNQNQNQNQKQNQKKNQNQKQIQKKNQKQNQNQKQNQNQNQKQIQKKNQNQKQIQSESDSDSESESDSESESDSDSNNNKQNQNQNQNQNQKQNQKKNQNQKQIQKKNQNQKQIQKKNQNQKQIQKKNQNQNQNQKQIQKKNQNQKQIQSESDSDSESESDSDSDSESESESDSNNNKQKQNQKQKQNQNQIQKKNQKQKQNQNQIQKKNQKQKQNQNQIQKKNQKQNQNKKQSKSESESESDSDSNSDSDSESESESDSNNNNQNQKQNQKQNQNQIQIQKKNQKQKQNQNQKQNQNQNKNKNKKKNQNQNQNQNKKQSKSESEYESDSDSNSDKSKSKKNQNQNQNQNQNQNKNKNKNKKQSESESDSDSESDSDSNNNKQNQNQNQNQNQNQNINQNQNQNKQNESESESESNSDSEDNNNKDNNQNQNQNQNQNQNNNNNNKNQNESESESNKKDSQTNLTLSTFENIGKIFTDLADKIEDTNKPQISINDPVFYELLQTMNKEITEWINSSKSKNNLKLTQEHQITEANIQKKLGKLPTGKNYSIIHFIQSINIANQIEPLIDEFKIHSKKIHSQSQNMISNICLKDLAPVLQSLKNWFLFLISKITFQKKRNSISDQKLLLKIKEWNLKQTTHTILSQYFEIWKHLGMDDYLIQNFLDKEKTKKWEKIEKQIQTISIEEKIISQKSAIEKFEPTVENIKTENSSKSEIIKNLYLFGQYTKKPPEEISDMKPLFSEKSDSKWNNFFQFPSKSNSKSKSKSKSKSKSKSKSKSKPKSIIQKIDLTDPEISLKLLPHLIHFHPNLIHLNWFYIDKESKCCYLNYPFLPILFSNLIDSQDFSNNSMIFLIRQMLSLIEYLNSKDFYFEKFDASDFVVDLSKNQIYLYNFANCKFNNQNLDIFTQMNSFAQQIVEKIPVFKNNLLKQIRTKNSVEKPITAKELLMKPILKVTQELPEMISTANLQFLSKSLIKIEPFSQEFLRIQNLVYYSCFPLNKDTILESQKQSLEIDSSFVIDPSLNEIYAFHGNLFDNCQLCLNLMKHENKKKIQNINNINSFQFSINFSISVNQAVFNHSNNTLSIQLCRLFLGGKNDYKFQEKENTNIWIIENINQFYPEYLIEFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R620</accession>
    <name>A0A9Q0R620_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R620"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="711" mass="81908" checksum="5E85E86028BE8059" modified="2023-09-13" version="1">MLAVKRALKQFQPKIQEAANRISSLIGKTLEFFFDWDEFMKSSTVNKEEKPKIIELVVERYIPNIEAAITEIVKEKPGQKVMSVIEKIIIRIITNQTDVTNFSFTFEDEDTTLVFNVLPAQMYYSSSGLVTPLKKLLDNAYNLNVWDKQSQAKPIIDEFKKKFTQLIGVEEVKFNIKLNFKEFLKSESVSQDDKGKIFDLTKDRYLPNIYSAFQEISQDLIGKNIFKNISKLTILIHVDSTTQSNFSFTLDDQLTTLVFHILAKQIYYSSSGLARPLRKILDDNYNLNILLALEENNKKITQFAEQFSKLPGVEDSFQIFMDVQQFLFSQDVSQDDKGKIYSLATDRYLPNILKAYQTISETVAGQKILSLIPKLVLRVHTESKDISNFSFSFEDDDKTIVFHILAKQIYYSSSGLERSFRAILDNTYNLNIWESSSKYEPIINGFSQKFAECINSQNPISIRLEMKAFLKSESVPQDNKGKVFQLISERFLPNIYKAYETIAVNDISKQALQLFHDILITFVPKDASKSNFSFEYDPENSLLIFNIVFDQIFYSSSGLERPLRTLLNQIFYLNIKLEIEQLQPALQEASLKISQIISNPFYILVEYNQLIADTSVDVDQKASAIKLARERYLPKIISPDSGIPHVCRDSDGIEAMQMFTKFIITFDKNDQVSNFQITMDENEGILYFWVKPSQIFYSPPSNIANLIEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R637</accession>
    <name>A0A9Q0R637_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R637"/>
    <dbReference type="OMA" id="HHLVRNF"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="722" mass="85294" checksum="8008C2B1B5244E6E" modified="2023-09-13" version="1">MNSQKNQNRKRNKFRNKKKFNKKQKPQQKKQQGIAKINSEKLDKETKRYFKSIRTIIDQENYGDEVNKISIVQNALIEIKGREIRLCIDPVCSSIIERLIRLSDYVNLKKLFISLFGNFYEMAKNQYSSHVLETLFYHILMMVQTESNSQTNSKKTNDKNKNKNKNKNKENQMDIDTTFQDLVIKMCDELNNKWKDLLKDASGSYFLRALIQLLYGEFILNENQNFQGKNYKFKKPIKKKAPIRVPIKFTSKLKEISKCIIGEEQEQEQEQEQKKKKKKKNSNENQNENQNENQNENQNENQNENQNQNENQNQNDNDPFWVSNSLFDQYSSPIYQLLLRIFQNDTKFYYQIVRKTCGIDLESVSEINLLRNEKKNDLFIFDIQSHIENLVCDKIGSRFMEVLFLTCDDIIYSNIYTHYFRNHLQNYSLHFQANFVVQKLIQQIREKPQIDLIFDELSGDSTKTNHFQQLIQQSRSGIIVELASACGKFHSKEKEFIRKLYHGLDLKLQTKYNSLFIMKIINIQNADPRFSQKKFLLEMIEKTNEKNEEKNDWKIQFVSVQGSLILQTILSSFEPQNTQRIIEGLLGFPGKIIYGLALNGSGSRIVQAFFEGKTSFENKNKLIQKLKGFFANLSLNSVGSFIVEKCFINSDVKTKEFIVQELIPIYDKLKKIKHGGFLIRTCRLESFMQKKQDWIQKQTQNQKKLEMFQEIIQNENENENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R657</accession>
    <name>A0A9Q0R657_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho/rac/cdc gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000123">
        <property type="protein sequence ID" value="KAJ5067933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R657"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032425">
        <property type="entry name" value="FERM_f0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16511">
        <property type="entry name" value="FERM_f0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="187"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="385"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="530" mass="61531" checksum="CB33E7000DB4E591" modified="2023-09-13" version="1">MAAFLLLKVSFPYKQTTKMMKFTPLTLVEEVKEQICTREGIENPESFGLFCTTGNGFWLEDKQPIFGYELWNDKTVEFKKNIFRNLNIVYLGELYTVPIDEILSVSKQIPIITRNLGITNYLNFVFVYQGRFLNENKNFFEQEIEDIDKAEIILKKDIPLSVKKIEIDANKKKKKKDEIISNPIFQKPLHVALTRGEKVLEVPTILTKPFEYVEKFGMDVEGIYRKSGGKNTIEKLKDLFDKSDDFNFQELVSSPHDATGVFKLYLRELPEPPLTWELYDKFIEADEIPENWERVKQLRRLVYSLPTPNFNAVKCICEHMFKVSQYSAQNQMGISNLAMLMGPNLLRSPDESMSAVVTDTRHQYSICATLISEYEYMFYNKEKSFYPPFAKVVYEFQASEKGELTIKVGEIIEVVKSDDSGWWVARGPNKKQGLIPSSYVEIVPDYIPPPRVKRKQVQGKQSKKQHIQSQIQILKDSLNEELKIKSELQTEKKELESILKEIHDSIQQEIQLTIKIENLIKAKHGDDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R658</accession>
    <name>A0A9Q0R658_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R658"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="472" mass="56525" checksum="2E098C22DDC3C57B" modified="2023-09-13" version="1">MTTSIIQVDDGSIPGKTQQEKKANYQYWSQFNLEKYYQKIKPFTFYTEFIPLKKFQIEILLKTLTDKKINQNEQIIIDKIYQDLKQSISNVKKICNCDKVFAKLSTRSPKDAVDKIQSKIISNLKKEKEKENKHQIQIQNQNENQIQFEIQIPNQNQNQNQNQNQNLNDDLNLKLVQIRKAFFQTMAFDSVEEVMEFFKWSFRIISDLRRFIEFQDESLNENQNQNQNQNQNENENENENENENQNQNQNQNQNQNQNQNQNQNQNQNENENENQNQNQNQNENQNQNQNQNQNQNQIENQNQNQNQNNLEFDDSLQIVIREFVDFSISNEFRGFVYQGKLNAISQYYSHCFFQDLVQNKESIQKLILNFFESINETIEKKCGFKNYIIDFVVLNNLDVKIIELNPFCEQTGSALFSWNIDKNIIENGPFTFRIRENKEDDKIIQAILNQWKEIIEKKKKKKKKIKKKKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R662</accession>
    <name>A0A9Q0R662_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000123">
        <property type="protein sequence ID" value="KAJ5067948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="148"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="492"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1763"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1770"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1781"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1792"/>
            <end position="1803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2587" mass="308127" checksum="8385710520E2F733" modified="2023-09-13" version="1">MISPSGNWMNKQNIANSIEFEDLFQGYNPEFLWEDRIKYIFLFILSKEFKKVEKVFILGETEKLARKCFNSTWHKKLEANDKFTFLQPFSEEAKKDGSQKEFLALKSLIFNDIDISELQQFHKENKSNYALTKDNFFKMIFIQQKLNAKLPVILFGETGCGKTSLIKYLCEDIMKQQLRTLQIHGKTKKKDIINFVKEAQEDAEKSQEKIPIFFDEFNTAPKKCIMLLKSIFSDKRINDMKISDNINIFAAGNPYRERETKTGNDTEARDVIIDWGLNADFGNGKEEIERLKKAIYPVHTIPNSFFDNIFDYGKLSENSEESYIQKIVQNKIKKIEPLPQEVGNLNNLFSKLLLESYIYVRQKSDDKLSAVSLRDSTKVLIIFDWFRSEKITEDLIEEKSNFKYIHQFIIALYLSFGCRLTLKEREKYYELLKKKIKEFKLPNLPKLNIPKIIENSQTKLMDILNIDFKEWDVVLNNSLQENIFSVFISCYTHIPLFLVGKPGTSKTISIEILMQTLRPPKKANKFLVNYNLPALKEFFIQCTQQTKASEITEVFNQARKYANKSSITETISVIVLDEVSLAEVSPDLPLTVLHFELEKADKKLLDQNKSFEKIKEELDVSVLLVSNWKLDPSQTNRGMFMKRLDPQLDELKSTTKKILLHFKPDFPSSFVKKIAKVYQLIFKRQTKELKKNYFGLRDFYYYLKMIGFNCSQNGFSYNNPHMIWNTIYRNFGSRPDFLQKVIPDIIKILGIKTPKYIPSSISLIKQNLLCSIVDLKLFPEKKLPENILKHPQNFSRHLMILTENLSILPLILSQIEKDTIVIFGSPFAESRKTHRIVENLKKIEFAVSKGKTIVIYNNNYLCEILYDLLNQNYIREKDKLFARISFGDATENILINENFRVIMVIDKKQAYEKELPPNLNRFEKQLVSAKDFISINKIHNFVKKQIHKLDLIEEYTEENIKKNDLIINYNSENNDLLNSLGVKLQNKYQQKNEFDNEIEEEILEKEGKELWMKLCKTEKMIQLFHLIQENEIEKERKYLKQFWDDFIKQYHFDFKSLFQEEISKKNIKKSIVLTYSVFKKQNKKNFPRVYKENSNEESYYPENYDKLSVDLSKYHTDNELKTYLSEKWEKYIDQKDFVLEIHHNITDESSFNLFNQVKYLIENLILDYYQIDKMINLENRHQSDIVFFLHLTSTEASKYFYYFFDDNWEIYYIDKLKQKYEFDLIKIANENLNLKDIFNNLKNSKSNIKDLINEITPIAISQFLDPYKSNYKEKLDSISNLLKNDEIQEIVLENVENMIDKGQEKEFEIYKWDLKEIIKNHKGNTSIIDHSFNTFREKITRIFALIINKLSQNGNYNLFKETGIIHYLWSRIIKEYKIPKIQELNENISEKQNIRDISIKYFNDLMKFELGEKKEQLLKEGIKFDYIDLFEKFSKQNIIDISLKDLHKIFLQTVKPILHKILSIKDSFDLLSKKEYSQIELDKSKNLFSLFSNYFNILEKLIKEKEKEKEKDIQKIASTFISHSKQNVQDLFLDLKLIKISESENDQLPNLISKWNEILLLREIFVEVHFPFQENQYIDTILKEIKPHFNSESNLDEIFNIFWIKLPKQLLIQQKVQDNNQILDQISQDEAFKNKKEVYKSIIFIFYNFGKILVQHMINDTSKINQIEEIYKKIISILIGEDKDLPKLDFETEESKFFNFMLNSLIRDLILNSQKDLKNQKIYFNILDEFLKEVDLTEENINNQIGISCLKILLNRNEINLKINDDNNDNNDNNDNNDNNDNNDNDNDNDNNNDNNDNNNNDNDNNDNESEYEYYSSDYLNEDKLQPLPEKFSLKEINNLANFRTYLIYNYKKAVKDMEKDFKSEKDARNWVILILKSIYHKYKQNKVIKFIEKNNQHLPSNLNLIKNIRKLKPEIPKFRINNGKVSNTILDNNTNKIIKTIKNDQIVQAIFDSVDIVESINFQPFKDLISDPMFLKENRKTSNLINIIHKSYWPGIPNYPYFNMFLNQSNQWFGCEAHNTFWYSDKNQNQYQMDCWYCNLPSDMSIMIPQPKLIKEIDQKLQNLSGYHCSVPEFDTFNIRELDPISYLILVILTNCIVLSMSISVINFRENILHLMNSPKTNEEELYKILKNNIVRSFDNLKEILNLSDQEVFEFYYKILIKMKEGKYIKGIQSQTINLQKEEKRNEIEKNFNEMIKNEKDGILKEIRKNRKRDVFVDLEERKLPWPFMEYQTKNYQQFVCLFKSNEENKKKYPIISFVNENQQALSRLKLFPGFLKFASAITNRYHGEFSQRKTKIINFIEENKENKEIEEWFQDFKSLWNDSLNDLKKIEIYTNLPQDFFTKNVMNEQKSIEECLIYNKESPVSIYKIIKTSIKHHNNLMKKLMEILNFSSYQKSNQEEKEKLHFPINIQEFESPKIIHLDFDKITQIINDYQDDQKLFAFLEEYLIESLNIEFKSKEILLEFEHFFFNDDINERVKRLNKRVWKYEAIPDKIWETILEELKLKNSVETFFNLIKTVIFSCSLTEFKEVELQDIPNTRLMDFIDKKLSLENDPDFLFFQNSSKYFSLIFLKNISDLYEKLKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6W7</accession>
    <name>A0A9Q0R6W7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6W7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010882">
        <property type="entry name" value="PCEMA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07418">
        <property type="entry name" value="PCEMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="172" mass="20372" checksum="FE6D6CB5AB05A3F9" modified="2023-09-13" version="1">MKKPDYLKGNDQLSIYQKNSFSFMERIPKQEIIKIIIESMPSVYIHLQDLLSKSYEIFKSNEENEENDSTEIEKFKKYQSCATTILQISTNILKSGNLSKEERDFLIFEFYYSIAFGKNINDPEYLQTKQRIRDSLRKSNLNLNLNLNENTNENTNENTNENENENENENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7S9</accession>
    <name>A0A9Q0R7S9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General transcription factor 3c polypeptide 4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7S9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="86"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="731" mass="85375" checksum="50C9F33F8C099AF1" modified="2023-09-13" version="1">MFHSLLSRQEITTPNSIYWNQDNFLAVKFDKLIKIINPEKINETKLIYLNDNGDYLKFEKLLSDYQVSGIPKLLPYWTHILQKPNSLIFQSICWSSSGCSKKKGCLLASLTTGSKIEIHDIGIETDLIETIDFSSILFSNHYLISTKQKNNIQKTQKRTKKQNAFDPNLYIAMIDKLTFRSICWSDIIVVSDTKYLLLLIGTKSGHVLFCGKEIEENQNENSSPNEFVFFNDVFIEESWIIALSCFSKNDEHFVAIGLSNGNIFIYQFKLQIKTNRNRMEIKGNLKNKSNKILATKLYSVISDMDYSIPINLKWIPSFRFGNEEKKEFGPFLFFSKNAQVFLWNENGIQYEKNIHIQIITGLDFNCQNLFSCSIDGSIKCYNPENSLITNLFDNDKEKVKQFFGFALSPNSLVYASAITNKSSQKKMKNSKVHFALIPKNDDITSSIIQSLEKLTKDIRLESWDISYSILLEESLDNLKILFDYANDLVIQFQSKIGDLFNSLFKEDEVELDVLFLVQKSIFIYSCFRERKEYKQEIEKSIKSSRFLIYSYYFALVLTNLRREAKENNLEISKIIDEIKFPVLLMIDYFILKSNKFQDHLTENIYKELEKLVLSFVEDLELKEMGKIIQEKQKEKIPKEKLIEFISAKEKCPICEEFIKIENRSHHYSDVHEILPLDRCMFSLQVLDEKVRRCVTCGKKSALNLSSNHFLFKNINLDFCLFCHSRFESRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R804</accession>
    <name>A0A9Q0R804_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_10838</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R804"/>
    <dbReference type="OMA" id="WHWTDDT"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5070569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="378" mass="42472" checksum="39FA089C91A782C6" modified="2023-09-13" version="1">MALSKILPPLEDETLIDKLSEDEITDRCLGMLLGCCCGDILGANCEFSKPKKLQKKYKRVHSFLDSNERRFGQYTDDTEMTLAVCDSLIKNQGLNAEHLAKTYGRYFDSRPQRGYGPSVSKILRKISQGEIDYRESGTMIFPEGSYANGGLMRISPIGFSFRNASQEVMHEAVRLALLPTHVHPEAIEGTFLQAFSIAKFTKMNPKDFDADQWINELINMSKVELIKKRLEVVLECLHKEMTPLQVVELVTEPNEFGKTFQIRTADALASVCYIMGKFGKNPEQALEEIVILGGDADTVAAILGALIGSLYGSSWIPNRWFKNIENRSFEGLYVGRDSLLEAGKLLAKLDLKEIPIQSNSVDLESNENIKEEKEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R857</accession>
    <name>A0A9Q0R857_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R857"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="272"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="326"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="492"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69714" checksum="FCAEE35628EDCE3A" modified="2023-09-13" version="1">MNEILYFGENYYPKLIKNEPMRITKPIQFKFENENENENGNENEKQIKQISSGFFSTIFLFKNGKAIEYLTQKDLNQNPEEIQIEENIQKVTVGVLNEAILTIEGNVFAKGKDINPNNPKEFINISSLIEDTNDRIIEDIVSGYNSIYLLTSNQNVYGIGLNQYGQLGFDSKAFQKTEKPILMMKNVSKIFSGNSSLHVFLLNSNQELFGCGNNEFGKLGLGESRRNETEIQKLTKIQIKNIPKGKIIDIQCAYEYSILFIEDENQNQNPKRKLYSCGRNLYNGLGQNDENAYEFTEIKSSLFENYNNILDISVGNGHTLILTSNSKLIVFGNNSYGQLGIGNTKNQPIPFQIELPKLRFNEDISNYHISCGYHKSFLYYSPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIKAHKLILKYRLNQNQNEIEKLEEIISKKSIKESNQIFEMIYSNNPRINPKLYFEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNRSFQIFEYWIYSNQIKDEIKITQEIINELQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8A5</accession>
    <name>A0A9Q0R8A5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8A5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10297" checksum="AABD4BA588FDB886" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEDIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8B7</accession>
    <name>A0A9Q0R8B7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8B7"/>
    <dbReference type="OMA" id="NVENRTH"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69909" checksum="1CA35FEC004A9DF7" modified="2023-09-13" version="1">MKESKIHWLPFQINHEGEAKVENYFEPLIKFSKDEKKIKGLFRGKQLKGRVIDLPKNLYGLILQEIPTKIDLINENDKNNKIENQNQNQSQSQIQIQSQIQSQNQNQNQNQSQNQNQNQIQSQSQSQSQSQILPQGQFPSQSQNENENENGNENENENENENENENENESQYQSQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQTQNESQSQSQSQSQYQSQIQSQSQSQSQYKSENESQSQYKSPSEYQSQSQSQYKSPSEYQSQSQYKSENESQSQYKSPSEYQSQSQSQSQYKSPSEYQSQSQSQYKSENESQSQYKSPSEYQSQSQSQYKSPSEYQSQSQYKSENESQSQYKSPSEYQSQSQYKSENESQIKIESQSQNNQIQMEMEIEIEMENQNETKDEICLFNNSFDIPQKKWKISKTFNKIYCWDEETSNPKEIPEKSFDWIQISRIVTTFMIIGKNDIPLYDADFSTTSNKETSSHLNQFIIYASLDLIDQIVWTKSNMYLKTVDKFNDSQVSAFVTAGHVRFVLLHDGKSEDNIKHFFTDVYTLFARILMNPFYEINTPIDSIMFDKRVKQAAKKWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8F9</accession>
    <name>A0A9Q0R8F9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein mon2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="WATVIRI"/>
    <dbReference type="OrthoDB" id="16567at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HDS" evidence="2">
        <location>
            <begin position="720"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="3">
        <location>
            <begin position="863"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1587" mass="183133" checksum="9799CA1DCA4B5512" modified="2023-09-13" version="1">MNIEKQIQTHLHELATEANNSLIKESCEKAIFYLRQINQSQNDLTTNFNVTISEEISKPFLLGIQTKNKNLIRISITAFTKLMNSRLTNDKIISTLFHQLRDMINTIKDQETQLKILQLIVIFVTSNPNVSEESINDSLHLCFFIYSKGTTILTNSAIATLRQICSMIFDRAVQKNETDSNLASSLFFNLCGFVQSKEVQWFKIKDIPFVIILELIEVLISTKKEIILTNPKILQVMKNELIPYLKKTFDQEEDLTLKTRKMRLFYLVLNNYYSVLTFEMKELLEVVENFYCNSKLNHKLYPLALDLLRSFFFSEDLNFSFFESLKHDDIYIKFIDQLIKISAKNSELKSVEKGFYYLNVSETVSTEPWNAINMLKMTSEVVVLVIKNIRHLLLHSLELQKQKENELTIQKVEQKRSQENNENQKNNLQNERVIHEVLIEFAKPLIVSLIQTSVNLVEFSENEKTIGLFLESLKSLIWVSGELSLEKEKDDCILKMALFCFPRELGLLKRLDNGNEDENKVQVKIEENRQKDQEITSKSLQAMKTMIEVAEDCGAVLRDSWSVAMETIELIEIMLDEQRQKKNTDFSAEIDIVRANVRMFFGNTQKQEDSSFIRIVKFLCFYFEKLQKKLDQKIKQNQSQQISISDIKPQALALNGLQEISAKDNQRLDLVWELFEGVISATISSPISALREKGLRIIFSIITQAISANDNNSEQKISPQMENKFFKTLEMETIQKNSSILFLTLENLSRLLHTVGHRITQGWATVIRILWVAAGSKDKAILASSVSSVELICSDFLRNLPPANVSSLLIPCLSMLVKQKTDINTSLTAISLFSTVCNHAARVSGEAITSTEKNLDDSKSEKSIWITVAVSLKDLSQDERPDVRNCVVQTLGTILASFGSLVGFSEWEFLIENVLVGILTSIHNKYSNELFRRNNTEQQQDIQEEILPQQLIPLSLEETNPWNKWAETFALSLREIAHVILLNCRFFQLTDFFMNSCQKIISFFEDAALQPHENLSVQSIQSFEELFSAYGCIETQTDQNNQTFSKISTPTLWKYSWSVFGRILNDFINKDHPFLMDGLKTFILVIKKVILRLGISAFTMNELKRFFRMFLLLSLTEQKKNYQLSSSYKLFPVTREILDLILVMIPEKSPQFWPVIFNLVLLPLTNIFSIQKSKNFSPFDLNTLNDNPFLENESLISNVIDPKHEKLQEENSFGNDPSKKGLLTLFAGDEVFDLDLSSPQIAATNNVYIGTYALKIVRKMYCERCPVEIAIKLSPRLLKVIMLLMLPQSYFMEIRSQNENLNEDSITNDQIRKKANKVFLSIVTHTFQELDLRGDQIKSVRDIYSFQNIVVDMIQLFVLSSQKIKLFSIKEAREEEKTQMNLFDIFKKFMFENVLKFYDENLVCKIQGILFEGAFITIPYIDLHKSSSFIVNKHFTRSKLSFKSISLIFDWIKFLSSQNLKESKLILEDLVGSLIVKTIGLLDHLINYESRSLSIPIPQNLQNTIIYLLKELKNLSLNPKYLQGTLTKNLNVIKNSNFQIPLEYNGSKFHLYFLFPILCDCMAIKNSSIQFAVSDLLHFIQIEYHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8H0</accession>
    <name>A0A9Q0R8H0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8H0"/>
    <dbReference type="OMA" id="MGIFSFC"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF1">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="90"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="350" mass="38868" checksum="0506A7DD68798C38" modified="2023-09-13" version="1">MYSFITNCALFLSTGILTTLFQQLIAYQGGSHPATLFPTFCVAIAMALVGYAKFLNAFKKNQSLPLLKQNLPEDEDHPKDETLSLNPKTSPQSRKTVARIVLLTIIDLSGNVTTIIGLVYSGSGIYQVVYSSVIVFAGVLAEKFLHKKLTKFQWIGIGLIIFGLFFSVVFSGSNTGSNSTVLFGIFMTLISAFLYAISYTFSEYLITSEQVSSPFELCSYMGKISSLLVTLYIFVVVMPNWGNLVSEPIEKKVGNPYLIFVTYLLLIFGAFFHNISYFSILETNGSVIIGIMQAIRAVLVFIFSSFFYCGIQSSQCYTFAKFFATLFVFFGTITYSAGETIYSKFIHSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R909</accession>
    <name>A0A9Q0R909_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase eco</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058921">
        <property type="entry name" value="PAP/OAS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45979:SF30">
        <property type="entry name" value="NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45979">
        <property type="entry name" value="PAP/OAS1 SUBSTRATE-BINDING DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1311" mass="154419" checksum="043E2B31E47C2DC4" modified="2023-09-13" version="1">MTEQKDLIYKSPRNIYEKYINIYFIKHIHQGEKFYIFGKAQKSWNKHKNNKKFVENFIRKNSSKFLNEKLNEKLNEKSNEKSNEKSNEKLNENLNENLNENSNEKLNENSNEKSNENLNEKSNENLNENLKFSHLPKFNSIQIQKKQIQCQQQQNHLPQFISEFLPGFDFENMLKSRKKDFYVLQNVAKQWCTYIQLKNEYSNNLIRTARHRSILAQSIKQVEEKASDLKVKLYGSRHLFSSSPIKDEFSQENEQNQINEQNQIDQINKENQINQINEQSQINQINQINEENQINEENQENNLNEDQINEENHSNENIKCTCKFCITKFLNNIFTEFNDFVSLILTSKKRLRKRIYRQRALAKKHAKRKELQEKEQNSTKKTKTQKSPKMKLEEKQEKNEEEHSVQSESCSLGCCHNKPENRQTKNAQMQNRQKQKDESVNEESNESTKCRCGCRCGDNFQQLSHLQSLIQNTAQALQSQQMYFFPQYPIANPSFYQPFFNSVQDPVTFLCFNLCYWDEVEYQLISKMNSGKGTFPLSIDLLSNLICEIKDADLIPLDYIAQRYQISQEFLSSLESQIALNFPVILVKKNNKSLFVNIHKIMQGNVLIDLINFCNISLSSEIYQDIQNHLEQKFHQKIQKQAFQNGNYLPAQNSHQCSHAMDYELRYFLQTEIIQRPSFLSKLPPNVGNLLQNINNHSKNMIQSEKKSDSLEAYSPLTSITVQNSLPNQSIAVKLKHPDFFYCHTLVQYLSEMSSLYPEECAMISFGNLNTIHVDGLSPLGSNLRIIDFFENQTNPFFQMPTRNPIYEQSMKFGNANEWIEGNYYNGVNKENYEENYGEVSLNQNHLNQNQLNQNHLNQNQLNQNQLNQNHLNQNHLNQNHLNQNHLNQNHLNQNHLNQNQLNQHLNQNQLNQNQLNQNQLNQNQLNQNQLNQNHLNQKQKSPNFTLTSTGYMLLKKTNPQQFYFDALGRKHLQTPKSISNTVISRATKNKSPTAESFANDLFEILQNNNKPIVSLIVDSGNPETDPASLLATIYYGRIWRDLNLDMLNVACHTPDSNKYNYINDLRKNFENQIHQLKYQTFFANQKLSEFFHQQDPSQKNFDLQEKNISDQLLNKIDEFWKNQKFNNEKINTKINETISEKINQGFYHDYKLIQRFLSAPLSVIQNDPTLLNLHKEIAFLLKHVDRKFHFLSFTKCFRNKCEFCQQNEFRSKNISSLLEKNDFRVFLPITSGNHPGHYCTFLEAAEKKTHQVTDFCLPSLSQKEYVQHFFCRALQRCRYFSLNQDDLERHEKVFHKPNPHNKDAPFVCCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9X6</accession>
    <name>A0A9Q0R9X6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9X6"/>
    <dbReference type="OMA" id="GMGPHPT"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="481" mass="52167" checksum="5C33198D2E38752D" modified="2023-09-13" version="1">MKKKIIIEQIIANFASKIYEDANKAIADIKDGSVLCVGGFGISGTPHQIIEKIAKNDGPKNLTIVRLLLKTKQVKKIIASYVGENGVFEKQYLEGEIELELNPQGTLAERLRAAGAGIPAFFTPAGAGTVIEHGGLVTLYGKNATVIKKSQPKESRKFNGRDYVLETAIHGDFGLIKAWKADEDGNLIFRGTARNFNPECAKSSRVCIAQVEEIVPIGTFKPDQVHLPGIFVNRIVCVPNPEKRIERLTFRDPNAKSKALKPAQILRHKMAARAAQEFKDGMNVNLGIGIPTLCAEKIPDGMKIKLQSENGLLGMGPWPQKGLEDPDWINAGKETITPLPGASIFSSSESFAMIRGGHLDLTILGAMQVSETGDLANWMIPRVLVKGMGGAMDLISSGSRVIILTEHCDKKGRPKIVSKCSLPLTGRQVADMIISEIAVFKVEKGKGLTLIEHAKGVTVDEIKSKTGCSFKVSPNLKEMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA97</accession>
    <name>A0A9Q0RA97_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA97"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5072897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27528" checksum="AC2895FF618F9013" modified="2023-09-13" version="1">MEEIKKLQENRENQIILETKNLLIDTLKEEDIEEAVECVSTSFAERELMSIVLGISKKEWDPLTIQIVELGVKCGLSVVAREKQTNKFVGCFLSQDVFDDSKIEFSKLCSKWEPLWAILDEFNKHKENIKKGEYLHLWTISVNEEFKGKKFANSISYANLILGAQNKFKYGISEATAPGSQAAFRKLGFEEKDYIKYSSYKYKEKYPFEFLEGGVSFVMKPLQNILKETKTKKTLFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAC2</accession>
    <name>A0A9Q0RAC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAC2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="181" mass="20632" checksum="F25176363DFACB69" modified="2023-09-13" version="1">MGGSLPKVDIPKKKAKRIRKKAKEGIKEYLPKYQEEYGKIVEEDTEKKLTSKQCHEQAKLKVKEPNLAKLKKSLGNDIGASFCDEVVEILNQDEKAKSLPESVKKKAAKKGIAMIVEAGIDKLLQAAGQRIFNEKREVDEPIEEDSETDGDDEDEQEKKEEKQEEKQEEKKEDESDEKDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAL9</accession>
    <name>A0A9Q0RAL9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAL9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="813"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="299"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1145" mass="135084" checksum="644449CDA4FD1072" modified="2023-09-13" version="1">MNLNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQRIQSKIKKFNKFLINQANKQIGLMFGNKKTSDFQIYCGKDKISIPCHKSILEARSKYFMINRRENKFNSIYFNNFSSEIVKPIIKFFYNGKFKFDKQKFDEYFKFANQIKLKEIKIKIELEIQSIFNIENILEIYFKSQQINSKNLSQNCEKFIFQNIQFIISNPNFDKYLNQNQNQIYNFIGLISLNQNFPNQLQIIQQIEQKWNQNNQKKLIKLIKFEIDQKENQIENQNENQNENSFSTLLNQILQTKSINQFQIQQIKNKSISQFQNKIVLLNSNIQEFDEKEFQPLQRNQILLDFQINDKQKENEKLEKIKKEIQEIQKEYKKWKKEIKEKFQKLIQNENEKMKKEDLQQFNIRIINLKDLFEQNRKQDLENFQKEIEEIQNKFKEIKNINLEEIDKKYQELINFPKLKIEKDLKLFEETIQQFKNEFEKRKEEIEEFKQLIQQNKNENENENLEKIDKIIQEIKNKIKFQKNKYLEIIEKKIQEIEIKNENLNEIEKIIQEIKNEIEKIKNEFYSKIDPQIKNIQNQNQNQNQKSKIKILQSIEKTTNFLQDLSNKIQQNNQKLIEIDVPFIIECMNNFPTNEIIQENGCFILQKFAKENERIEPIIKSMNNFPNNENIQKYGCLALGIIAFNNENQIEINNLKGIEPIIKSMNNFPNNEDIQKYGCRALGIIANNNENKIEINNLKGIEPIIKSMNNFPNNENIQKYGCRALGNIANNNNENKIEINNLKGIEPIIKSMNNFPNNENIQYYGCLALGNIANNKKNRIEINNLKGIKPIIKSMNNFPNNENIQKYGCFALGNIANNNENKIKINNLKGIEPIIKSMNNFPNNQNIQYYGCFALGSIAAYNNENKIKINNLKGIEPIIKSMNNFPNNQNIQYYGCFALGSIAAYNNENRIEINNLKGIEPIIKSMNNFPNNQNIQNQGCRALGNIANKENRIEINNLKGIEPIIKSMNNFPNNQNIQENGCLALGNIAYNNENRIEINNLKGIEPIIKSMNNFPNNQNIQKNGCFALGNIAYNNENLIEINNLKGIEPIIKSMYNFPNNQNIQENGCEALRNIAFNNKENRREIKRLKGIQLIKIAIKKFPNNQDIQYYGKLALKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAP2</accession>
    <name>A0A9Q0RAP2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAP2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054000">
        <property type="entry name" value="MLKL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF20">
        <property type="entry name" value="F-BOX ONLY PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22215">
        <property type="entry name" value="MLKL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="213"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1245" mass="140789" checksum="3498127BE06914DB" modified="2023-09-13" version="1">MNYNPTLTPANMVTQILFLGRDFSHKPKQAKFNKNKIQRFSERAKTIINHIRKMNLQSDSNKAENLKEEITHTFNFFKNSSNFLLKHTDTNWIHQFTKHGTAKDHFKKLFEDMKVCGLSLSQEISEMWGSTKEDEIDEEKDSDEFFQILEDLLEDKVHLDKIIEQQTKIKSINKNQIYEALEHQKFLFSLHKEYEPENWERNIHISEIPPSHLKFGNRIGIGGYGEVFLGERNGETVAIKQLIDLQTNSDVVQQFKKEVYILAGCQHRNIIQLLGGRISGPPYYYVMEYHKLGDLSNFIHSIQKPLYILLDIARQVCVGMQFLHDKKVMHRDLKPQNILISEQDGEFVAKIIDFGDCSVDKTLQNTLKGTPGRIAPEVINSEAGYTFSADIFSFGMILWEIYHRQQPFSGLTFNQINALLISQKNIEEKRPKIKEDCPSNLKKLIEECWAEIPTERPSFKKIEHELSEILVEMEKMNDNQNIENDEKPIVKNIQKRIVSVKNVKSLISACRTASPGEVIELSSGTYHVKKPLVLNSSEIIIRPKRLMRNQEVNIQIDNSLKPLIIIKGQKNIIQGIHLCCYFESKNSNEIFKENIGIVEICEGNEHVIQECTIESKDSRMCCVFVHGSATNTTIKENNIFGGKNGILLFDKGYSIIEKNEIFSSFENGIRCDYESSVDIFENRIHNNLKNAVMIKNSRVQLKLNRISSAQFGVFVKKAQYVLIEQNTIFMNSSIGVYIENESKCDILSNEVFQNRIGIDIDETSKVKIEKNTLSKNEDKQINIPLSNQTIIQKENEIEEIEDDTEIDSGEDDVQMIIHEQQKRIVDISGKTGGFKSINEAISISSPGDTIKILAGIYQEKIILDKENLTIKGAKNQNVSLKFKKSSPLLIQAQTGTISNINFIYEGERQYAVEIPKGSVCLTDCTIRGQGVACVGIHDSANPQLKRCKISHGKVGVVFYNSAQGKLIECDISENAIQGVVITTNATPVLSHCNVFKNNQGGIAIYDSGKGEIEHSDISFNKLSGVQIRSIAMPVFHDNNIHHNQQAGIFIFESGGGEVLKNKIFENGKSGVAIKSKSDPKIFENEIYSNKESGVFVYNTGFGSIENNKIYSNSLSGLQIKVESNPRVKGNSIYNNEGSGVFVYHHGLGVIEFNEIHSNNVHGIDIGSESNPEVHSNRIYNNELGGLFVLTNGAGVFTQNLFYSNQDPQIFIQSRSSPTIDDSNIIPENGIIDENKPMSDQSSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBP1</accession>
    <name>A0A9Q0RBP1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBP1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="109" mass="13284" checksum="164D79399E08E1E9" modified="2023-09-13" version="1">MWSEDDENNVNDLFRENIEQESFTKLETEPIKQTTEKDDIATEIQALIQQKNELIIQAYEEYQTEMQKLIQEYKEKKREYDYEYALAFLNFKEKMNQLDQDNQSKKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCD0</accession>
    <name>A0A9Q0RCD0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCD0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="240" mass="28295" checksum="9F85B02138C396E0" modified="2023-09-13" version="1">MKRVLNDDEKPLELGLTLSSQEPDEWKSFLHFKIARKDLLTVKIFRRNSSEPLAFIINENSNIQKLIELIASKFPVEDIKKTFIQEQFGNEKPQIIDNQKKIIDIIKGWGDKCENYKFLYKDSNLQIKGMEDFFYKYESQKIEDVSFDEINRNIMDIVVEGNSFYLKNEGFVDDTKGNSEFIHDNLSLLDRIKKEMDDEDSQFSKYLQRSKQMIDNKIDAYLEIAVPKVAKILELKDVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCR8</accession>
    <name>A0A9Q0RCR8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCR8"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="475" mass="54211" checksum="DE9656582E1A883D" modified="2023-09-13" version="1">MEQDLKQKFINHSQQHLFDFFNELNEEEKKNFISQLKQIDFEEIDRIFETFSENTQKNIQSLQNLLEPIPNIEKVSTMSLKRQQDLFDLGLKAIQKGEVCCIALAGGQGTRLGFDHPKGTLNIEMPSQKSLFEMQAEQLLKLQSMAKKEEAKTPTIPWYILTSDSTHEETVKFFEENSHFGIGKENITFFEQGKLPGFNSLEEKKIILTNKGEISFSPNGNGGIYKAIKDSGVLEKMSRKNIKYIHVYSVDNCLIKMADPVFTGYCIEEKAECGAKVVAKLHANERVGVLCNKEEHVHVIEYSEIGKEKSEMKDKNGDLLFNSANICNHLFTFDFLKKICLDYYSKMPYHKVQRMVNGLKDGIIQPFIAIKFEQFIFDVFPFAKSFAVLQVERENEFSPIKNKTGNDSIETAKIAISSLNTKLVQQAGGFIDSSNSNLFEISPLVSYNGENLQNFVKGKTFKLPFYLNLDAIQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDL1</accession>
    <name>A0A9Q0RDL1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease H</fullName>
            <ecNumber evidence="5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_07892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5"/>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDL1"/>
    <dbReference type="OMA" id="ATWTECA"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000002">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="12">
        <location>
            <begin position="421"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5074849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="555" mass="62971" checksum="1A53E8A1F2F90A24" modified="2023-09-13" version="1">MSKFYAVRVGRQTGIFFSWLDCEKQVKGFPKAVYKSFKTLSEAENFLSNNPNLSTNQNINSIQNLSTNQNINSIQNLSTNQNLNSIQNLSTNQNINSIQNLSRNQNLNSIQNINSKFYAVRVGRQTGIFFSWLDCEKQVKGFPKAVYKSFKTLSEAENFLSNNPNLSKNQNINSIQNLSTTQNIKSIPNLNSIQNINSNQNIKSIPNINSIQNISTNQNINSIPNINSIPNNIQNINSIQNLKSIQNLSTNPNNIQNINSIQNIKSIQNKNYQPNISISKIQNIKSIPNISTNQNLSTNQNINSNPNNIQNINSIPNNIQNINSIQNLKSIQNIKSIPNLSTNQNINSNPNNIQNINSIPNNIQNLNSIQNLKSIQNLSRNQNNIQNINSIPNNIQNINSIQNIKSIQNLSKIRPEKKRKENEFLEVFTDGACLNLENVSKPLEKKQTNNSAELTAILEAIKMCPKNKNLNIFSDSQYSINCITKWSKKWKKNRWKTTKGNKVENKELIQEILNEISKHSGKIKFTYVEGHNNDFGNEMADFLAKKGAFENRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDM0</accession>
    <name>A0A9Q0RDM0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sca1 complex scaffold protein scaa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037474">
        <property type="entry name" value="ScaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516:SF1">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1396"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1256"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1339"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="388"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1339"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1354"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1503" mass="177457" checksum="D3C4CEAC6A0CFC22" modified="2023-09-13" version="1">MNKNNKTKTQEKNQQQNQPKKQEKPKFAKKFETKDKKEYYGPDIDLSTPIKNQKKENIQIPFFLNIDGEFLDIYLQKVGDLKNIQNKIKQKYSQEIQKEKEKEMKKKIKKKQNILLKNIPQNYQNLPPFPLIDNYKNYSDYEQAVLDWKANVEKIVGFAKLPHMMGRVYPRPFLNQDKTEIEDQERSSGTDSGRTSSDIRRTSSGHKNPIPKIGNLSHISQFTKSQKEIEDIKIDENEKEKGPPKFYPETELVMKENESWKNQLIIPPPEVDYFNTFEEYEQANINWAKLVLNQNKLIPLHPKQFHDLYSIKTVVEIEEIQKKKKEKENAILFRERTKTKRTKQINTRNDFNDWKEKIDMINNYYSNNYGKFAIENVRFILTGKNLRQRNEEEYLKEKERKRLEFEKEMKRIENEKKQIKDNEETEMLMKHSNTENVHKNLSKLTQKKEGIGIWKKLKEETKKHIKDFFQTITLHTEYNLREYKSSVKPILGKVHGIFTLTKQSGSITSSSINIQSEGVCAIRRNDVKETIIQRSFDCEPEIESKSVFFQIPQHDLKGKINVANFSENIYKLRKEIDQLSNAHEINKLNSFYYPKKFDQNKIKKQQAVIEEFSKNDQQYFLANLPKLFQSELYLDSFSELLSKYLVHKFSEITFSNFFYSLTLPEQFKDILEIFHDSCSLLTHAKIGQFIIEGLQGNYAQEIFKKYCTDFDYSNLFHIAYGANLLEKIPRKVFPPYLFLNYYKSPFRNYEVEKTILSHYYLSIIQQKISDQSQGFLFVGVSRSIPQLISNMKNTMIQMASINIPFLQNDLFEGIKSKSSMISSYYCLILEHLVGIDDDSLIKLLQNPKINLLENIRIFSKHKFSHIKFCIQKIWHKLINIQAWRNHISVQYSSSYSKLIEDLENPQKDLNENPKVPLMVVLLTEFFRMVFSKKIENNYDSESLQLLRSKFFYDIVARIKRDIDSNSTTNTLIYLSKILVLMQKAFDKFQLITGTKENKIQIDEKKQFLEINLSFLNTIIDILLRAPQSLNQMKYNFIVLLRRLLENQSVFQIVEDERDFFTHLSSLFRSMTEDKICRELWGIFFDSIAYHSGLVSKLGNLNVLSGLLQWISSVSHPCIIIYGLKTLNHILNLDRLKDEALSKKILKMRNSSKKPFKDDLKFFTDFFEKNKCFVNIHMIFKKFENQKGTIFSILSQIYLTIFENQNCKKIFAEIKKNESYVEGFETFSTFFTDQKRKKFAKEYEKFLSQISQIDSKKPNLEEEKPKEKNQIKKENQNKKENQNKKENQNKKENQIKKNKTEIIKRKPEIIVKKPQQVISQQEQFLPLRADPTTADSVWFEEEKQKKSIPEKSQFKKSSGNVSGKSSNKKSKKRKTLRAAAGKFWEDETLEQWPENDYRIFVGNLGNDVTEEVLSKAFSQFKSFTKCRIIRNHISGKVKYGFVSLLDPNDFTKAMKEMNGKYIGSRPCSLKKSNWDKKSLEHFLQKKTIGLGKKKTRTSNSNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDV7</accession>
    <name>A0A9Q0RDV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDV7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="617"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="718" mass="83753" checksum="E64BFCEE0F8BB275" modified="2023-09-13" version="1">MNFWKAIKKNDFQTLKLLIEKGIDINSKKTYNKTALHYACQYNSIEIIKYLIEKGIEINAKTYHNETALHYAFKYNSSLEIIEYLISKGLDPNAKNYHNETALHFACKYNSSLEIIEYLISKGLDPNAKTFINETNIHLVCENENTKSSIEIIKYLISKGIDINAKTNQNKTALHYIFQKNPSFEIIQCLIENGIEINAKTHENETALHFVCKYNSFEMIRYLIEKGADINAKTNRNQTALHFCCQYELKSEIIEYLISKGADPNAKTDEDETPLHICCQNESLRTIQILIEKGADPNSTAKYKETPIHIACQKNYFEIIKYLIEKGANVKAKANGNQTTLHYACQNKNASTQVIKYLLQKGIDINSKTYGSKTALHVACQSSSNKIIKLLIENGADINCQDFDGITPLSLSIQNSNLKLTKLLLMNDANILKLRKQEITNQIILLFSQIYSFNEDLHNLLYSNDNFADLQIKSKDYSKFQVHKLILLARFDNNETNLQKFINICNQKPKKEIEIALNFLYTGFPNFSQFQKKIDKKNQNQNQNQNQNPKKTKTKRKSFNQKILKQKQKEELIKENEMEMENFFKEIGFDSKWIELKKGRKGIIKDFDKLYQDDSKKDFRIIIDEKEIKAHKLILILRSDLFKGMFQLNVNDSSNQVHDYSRKSFETINQLIYFLYHDKFNNEKEILKKIKKEEFEELKDYYQLNPNSIIDLFLMKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDY5</accession>
    <name>A0A9Q0RDY5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulation of nuclear pre-mRNA domain-containing protein 1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDY5"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16981">
        <property type="entry name" value="CID_RPRD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="581" mass="67463" checksum="628BFB3FE11A2B7C" modified="2023-09-13" version="1">MTTFSETLLAQKLDNLSNTQYSIETISRWIIFYREHSNRIIEVMLEKLKNSNTERKIIYVYLINDILQNSRRKCDNFLQGFEDKISDVFVDIYSNSEEKTRNELFRVLTIWSDRHIYPLDFLQNIKTRLLSLVVKNKKFPKNQVRKRTLDKMGKKNPSPIAPIKKEEPNQGKNSAHKFSNIKEFTEHLESLDLLFEPLVSSNSLELSRKVSQDFPREEHTGIKYIEALNQYKNEISLEIRNRENFVSILTKLITKQNKRIKISAYQMNECSNKIKTANDTLINQNDDMDMFIVPRANSEPIKVIKEDPIKPIAMNPVHQEKPAINLSDNFSRGPNANQHIPKIEPSRENPYLKKNIDQPPIKDIEKMKNSIKLFLDEQKLNLQNISNNIKPPNQENKAIPINANLNPNNNPVNINAHMSDNINPNDKNYLQNFPNINNNINNNINNNINNNILPSQNTFPNNLDNSKNFEVPNSLPNYLPVQNNSSFFIQNQDPNIQTNPESQNFYVMNGMQPPQVNQQPPNSPTHFIWDSSPPPPIQTPIHYNQFPQSQQWNLNGFPSQLNQNLQTNSFAGISDSKRIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REL1</accession>
    <name>A0A9Q0REL1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fip1-like 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REL1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="505" mass="59166" checksum="089864BE841C737A" modified="2023-09-13" version="1">MSDTDDPELEDEKQLLNQFKNDFDTNTTEKNFKMFLSEAAIYKQKNLDKARFSGSVLKNKSERQALIVLFEGFIFIRYLVSKFEDLEMEAFQIVQTKLSSASKNNLVLKSSVSKSKVIIKFSQDLTKINFANQFKKAKKMLKKVKNKKNPKEKHTFFVELIDPYSNRNLFMKFIVSEDSIFLKSHKQNIFELENNFELNIEEKNNSLIKLIFKRENSGYLLLFPSYQKVQELNQYVNSIKKEIETNDISINRTFSSGFKNVVNSGSIFNVIFLKSTHKFESQKRKIQINNGKVIILNRDDQVEDEIEILGNSEVSIHTSKKKILKAKISNWELILQFETKFLCGTFTSLFNNEKMKVRNLNAPVFSVEFMQLPQITREKGKIECLYKIFQFTFEKKNLIKMYDYKADSLKIQSHPEYKKIISFQYETDPIFKIHFSSEKQAKSFIEIIISKRDENSNEDENENENENENENENGNENENGNGNENENENGNENEDENENSNSNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REP8</accession>
    <name>A0A9Q0REP8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arginine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REP8"/>
    <dbReference type="OMA" id="DQQITTR"/>
    <dbReference type="OrthoDB" id="5590314at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019546">
        <property type="term" value="P:L-arginine deiminase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47271">
        <property type="entry name" value="ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47271:SF2">
        <property type="entry name" value="ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02274">
        <property type="entry name" value="ADI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="399" mass="45986" checksum="8B01FB34D2F68FE3" modified="2023-09-13" version="1">MEPKKSYIQIAELDQAHTIIMHAPLKDPNFGSLHPKAFLYEKQVSFEKAKKSHNEFVEKLKKYGVEVIKIEDVYANLKREELEEIAVNYLKYQFEGDVSDLTEENKFYISNEYKRIALSTLSVEQLLDIILYQPTVLLQQKNRDLSSCEIVHHPNTNLTFTRDQQIVTVHGLVMGSFANHQRKREVQIMRKAFEIMNIEIKGNVESPGFVEGGDFFPVSKDLSLIGVGCRTNHLGAKYILDNNLFGTRRVGFVVDEMDKNIQRMHLDTIFNIVDEKRVVLLDSIMGDSKIRRVVWEYVLIDNCYQLNRKVEFSEFLKQEGYQIIPISDQQQREYMLNFLNLGIGSDGKAIIISVHPDLEKVLREAGFEGIVDYVDYSGITAMYGAAHCSTQVFRTPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFA5</accession>
    <name>A0A9Q0RFA5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFA5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="18047" checksum="673E615B32FD7900" modified="2023-09-13" version="1">MIDFNETKLIEKEEENDIKNLPNFRYLKMKNLQIQNISQNSNKEILNRKAIQLLNSLERYNIKNLSNPLDVFLNSKKYQNQLKNSKEDEINDLFYQLYSKIQWIDNLNQKTNQDIIDKQIQINQLKHNIFFSEKKYKQKKYQVKKFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG47</accession>
    <name>A0A9Q0RG47_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG47"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="261" mass="29000" checksum="875FB1BEC358DEB8" modified="2023-09-13" version="1">MNISDTFGDPPLIHCVKEQNLELIEFVLSQSTKVDTKESNGMTALMHASLLGNEEIVTKLLEKGADPNIRDKKNMTATLHAACHGKKKIIVILKKAGDKTDIKEINGAFLIYLAKKGDVKNVQRLLQKGADVNFADSKRWTPLICAAHYGRIEVVKELLKLPSVLVNAQAAMKTTALHHSAREGHADVVEQLVSHNADINLQDNLGFTPLFYAKDELTAQKLLLFKDKIDFSLKNNDGLNALDFHKKKKNSKIVEALENLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHF1</accession>
    <name>A0A9Q0RHF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA replication regulator dpb11-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000014">
        <property type="protein sequence ID" value="KAJ5080094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHF1"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="87"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="242"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="497"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="598" mass="69934" checksum="70DC43FAFD1E40C1" modified="2023-09-13" version="1">MTLFQSNFFYISENISTNPKKLFNILIQNGGKVLEDFNENAFIISEIDPNKFNQYPSNLITPNFIYESISLSKKIMKLNHPFHSYCLNGENIYFNNLSTNKHKKILFQILCMNGQYSTEITPQVTHIIIDISEENRQIINDPRVIDIEWIEQCWNNHRNIKSIIFPQFSKCCISTTGFSEEETKNIENLINKFSGEIHSAFIKKTTHLITKIFKGSKYESAIRQKKTIVTIDWLRKMILLTERNQFFRNCIFYFDPNSIKSSIISILKENVLKFGGIYLDNFNNQVTHLIIQRTDGEYYYQPEWSENSKIIDIEWINECLRKKKLVNISNFSIFPTNLTEESSFRSSLTTNQNVLSNEISSDSKISQNSRTNSIAIDDIYKRKSKSFNKKKRDSNIDIDIEFGNQNQNQNQDQQIKRQKQRKQQKNTEKEIIPKSIPINNLKNPEISISLNRNIENISIENEKEISKLNLSANYQQNTLEYIEKQNEISGLNYEPYEANNLFQGISFVFVQVTKKDEEDCSKLIKEHGGKIEDKITNETKYILVSHGANILITIPFEFMKQFRISLSGFKKQMKIKNKYIIKQLGAKFTGTLSRKIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHX1</accession>
    <name>A0A9Q0RHX1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ovarian-specific serine/threonine-protein kinase lok-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_14532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000034">
        <property type="protein sequence ID" value="KAJ5079199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHX1"/>
    <dbReference type="OMA" id="NLQECIV"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="422"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="534" mass="62380" checksum="AA9AA27479AA96BE" modified="2023-09-13" version="1">MKNEREDLLFQNFQPTKFIGKGSYGKVYLGKILKTKENCAIKRIDLRKTRNLENKRKKLNRELEIMKKVKHENCVKLFFIEPENYQDAKVVYLVMEYCDMGDLQKYIQSKQERISIEEAQEIFGQIVLGLKYLHQKGIVHRDLKPKNILLQKNEDSKFGYTIKLADFGLAREIPRDEMGKSLEMNSILGTILYAAPEILFEGFYTSSVDLWSLGAILYEIITKNPPFQGRNIGDFVQKYNRIANKSLPKNYLKFIPKECNDLIEGLLTVNPNKRMTREELYNHPFIFEKLDELIGKSQNLSDLEKKIIGIAKEDFKKQRKMINFHLKRRKEKGFIELKRIDLYEEIKDIFSIIESSSNSLDYQKKMIGIISNDYKSDKVSLSIGDLVKIININQVNKTCEIEIGFGIENQTEEIPLFFLCFYEKIEENNENQENNENQENNENQNSIQMEIEDNQIQIEDNQIQIEETKKTKIKKKKSLIGIAKIDSQNQNKDILSFSKGDEVEIIEINGEMGIGYLNGKEGEIFIDDFDIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4V4</accession>
    <name>A0A9Q0L4V4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pe repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4V4"/>
    <dbReference type="OMA" id="HEQATAN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051860">
        <property type="entry name" value="Plasmodium_CSP_Invasion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44826:SF3">
        <property type="entry name" value="SPORE COAT PROTEIN SP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="822" mass="95156" checksum="91C7A65E214CD494" modified="2023-09-13" version="1">MTSIQKPKSKLTPKTNLSSKQIHKVKSKEIKKEDKSEVNEKTKENAKKANSPSNKKIQNKKSLTPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPTTKPKTKPTTKPTTKPTTKPTTKPTTKPTANPKTKPTTKPTTKPTTNPKTNPKTNPKANPKTNPKTNPKANPKTNPKTNPKTNPKANPKTNPKTNPKTNPKTNPKTNPKTTDKTKPITTDKKLIDKKLIDKKLIDKTKLIDKKPIKPTDKKTTEKTTEKSKEKSKEKSKEKSKEKPKEKSTEKSKEKPKEKSTLTKPGIKKNTKTTSTPKNTPSTPKKTTSTPKKTTSTPKKTTSIPKNKSQEKVSVSQNKLGNKDQNLSKSKSQEKVSTKIGVGNKSKQIGKSNKTNNSKLSPKTSLKSSTTNPKKNEPKKNEPKKTSSNLKKPSKLTSNISPNKKTVSKEEKDAKSSPNLKPKASLSGKKPLQKTSKTTNKKQIQKKETKQEPNELETKQEPNEIETKQEQDEIETKQEQDEIETKQGQNELETKQEQDELETKQEPNEIETKQEQDEIETKQEQDELETKQEQDELETKQEQNELETKQEPNEIETKQEQDEIETKQEQDEIETKQEQNELETKQEQDELETKQEQDELETKQEPNESETKQEQDELETKQEQNELETKQEPNEIETKQEQDELERKRKEQEEKERKRKEQEELERKQKEKEEKEKKKRKRRKKKKKKERTRRNRKKKKRTRRIRKKKKRTRRNRKKTKRTRRNRKKTKRTRRKRKKKKRTRRNRKKTKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4Z2</accession>
    <name>A0A9Q0L4Z2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4Z2"/>
    <dbReference type="OrthoDB" id="10649325at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="18780" checksum="BF6B2CE39CE23C0D" modified="2023-09-13" version="1">MADKQFEENLIFKNILSHGLGVSSKHTGKSITIHDLHQLPIGETFITTTGNVIERISENQGVLNETKIFEFGIGINKKSNENIGEDSIKKSMGKAQQEEEKLSKLACTLQSKFLEEKYLPIIDIDEFLYPEINEENWLYSPNQSLLLERRTVKENFDPHSQKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5K1</accession>
    <name>A0A9Q0L5K1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5K1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11612" checksum="4BBBB6E176971B46" modified="2023-09-13" version="1">MRTSEVLPIWIVNSIIIIIIIAPSLGVASKDKDKDCSKPLWTWVLVFNIFWATREGVKDECGKLYSVTLGESIVIISLAGCGCLLLCFFGIFWQFFFKDLTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L618</accession>
    <name>A0A9Q0L618_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L618"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="237" mass="28638" checksum="726B52D24AE04631" modified="2023-09-13" version="1">MEQEPFAIQMLKDLDQIQKINSENQLKIIKLQEENNFLKKQNKEKDSKIETLQNNSKIERMQIIQELNQNLKSQEILKINNQFKNENLNLNQKIEKQKQEILFLNQKIDNLQKEINQILILKQNFESKNQILQNQLENLNLKLKKNEEKNVNEISQKKTEINQLKKLIEQNQHLYETELQKERINYEQKLFKITTSSSNSNQEKLLSFYKKKLMEQKLAFEKEKKLLEKEIEKVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6L6</accession>
    <name>A0A9Q0L6L6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btb (Poz) domain-containing 2a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04264</name>
        <name evidence="2" type="ORF">M0811_13739</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6L6"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="504" mass="57095" checksum="C72DFA164EFD21AB" modified="2023-09-13" version="1">MFASLHEVFAQYINHKNTADVRIIITEENPTTKTTTTTTQSQTTTILYAHKFVLSTASPQWMNKFYNPNWKDPSSPRLFTLKFSDIDADSFQIVLEYIYTRKPNIQSRNVVKVMSFAQKYQMFDLLKMCELFLSSNLTLENCLAAFEFSLKNSNKEIEYQAKEFIELNSLELFEKVACLVSLEELTIVEILKLKQIRASELSLFNRLMEWGQWRCYSHNLKANLSDMKEMLKNVLPFIRIELMGSKGIETLEESGLYPQEKIDQAKSRLLQELLQNREKDTTKLKPISQIKVLLIASDDSAKYREDVKLSITSTGIKNVDIFDATKGVPQLQQLQKYDVVFVYSASIKFLNAKKTGDVLAKYVESGKGLVLCSDEALLRGSEGEIQGKIIDYLPVEKGDHICDEKTELGDINYTRHAIMNGVNSFDGGAGSPHCSGACTKSGKVIAYWDDGVPLIVVHRKMDNFGNIVILNFQPPSDKVDAYYWDSKTDGAKIIANSVQFAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7W3</accession>
    <name>A0A9Q0L7W3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7W3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040119502" evidence="2">
        <location>
            <begin position="18"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="176" mass="19493" checksum="D10776BEA30608E1" modified="2023-09-13" version="1">MFRFLALLSLLACGVLSFLSWVMPYLVGSYTSGVSAKYSFGNFQMVCSGSDCPSNDDWKYTLDDWKDQDKDVYNGLCANIAMTLIALIILVAALFLLFKKSGITHLVFVTGGIFVFIGIMAFVGKFQNSDYHTMLKDMHDANSDFHWSYSASTAFSIIAFIVALPGAFFAMKAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L850</accession>
    <name>A0A9Q0L850_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L850"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="323" mass="37893" checksum="B97613F6599F2ABD" modified="2023-09-13" version="1">MLKRKMKKLLPVFLYLIIFFSGFILGIAITETTETTETIKKMEEKPKNRKWATKENGMDVCILMVDRTKLDHYPQGQYVEKNNLIPDYSSSVYHNYNYAKQLGHKFFRMSSFHKENNEEYFPPELQESCLKCRDPHWDRVSGIYYVLKNLECDGVVYIKPGIIIDDFLFDIKDVFKVYSEDEKKEVSFIIPRKSLNDESDLDLDVLFIINNEKALEILREWYNTPITNPSLNKYLKTKDSDNVVFKQAIFSNDKYRSFIMTIPKLTSQNALHSQDLFIKSEKIVSKNGLADYVISSFCYNAHKSYKKKINDASLDPKVFCVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8J4</accession>
    <name>A0A9Q0L8J4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8J4"/>
    <dbReference type="OMA" id="FTGWYVY"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="244" mass="28875" checksum="89AEAC99E3523A9E" modified="2023-09-13" version="1">MIFPNPLILQQAPVFVQQESETVRNRFIRKIYTTLTIQILTTYIIFRIILSLPLKQREELFSGSLILLTTLIAIISLGLSIFERNKYPRNLVYLALWTFFQALTLGFSLASISQPSIVKIAFKFATGIFALLTMFTFQNRFSIDRYSLIFFTSSLETLWIVLYTFIYPADFYYYGRYYLFSLISIVIFSVYVILDTSRILDSVNQNDWVLAVILLYFDFIRLFMKLLRLLQRISENEKKKQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Q2</accession>
    <name>A0A9Q0L8Q2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8Q2"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903:SF8">
        <property type="entry name" value="MAX-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903">
        <property type="entry name" value="PLEKHH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="23991" checksum="15927367A92E76F5" modified="2023-09-13" version="1">METLKSGWMLMKKKQSNSYKNQHFFVLEEGVLYFYKNETTTKPLGSISLSQSQIKVKNTPNNTEFQIITEKKIFFFQTNSSEKQLEWITALNSQSKLKKLNYILDRLSYNIIEAENRLASLQIQMFLEGKETEDIDENKSQFEQIQTEDPLLSLFIQSELKIQKKNQKNFLENENQNENENLDQNLDKISIQKIDENLNEIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9L3</accession>
    <name>A0A9Q0L9L3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin alpha sarcomeric/skeletal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9L3"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="374" mass="42624" checksum="D88135A9940A5AB4" modified="2023-09-13" version="1">MDNYETAPIVIDNGSGMIKVGFAGDEAPKKVFPSIIGRPKHLGVMVGMGQKDSYVGDEAQAKSVILNLNYPIEHGIITNWDDMEKIWNYTFYNELRVALEERPILITEAPLNPKSNREKITQIMFETFNVPAFYLENSSILPLYESRRTTGIVIEIGYGVTSVVPIYEGYAPPHATQTMFVAGRDLTDYLMKLLNEKGYSFQTTAEREIVREIKEKLGYVALDFDEEMKKELNLIEKDYELPGEELIKIGNERFRCSEPLFEPSLLDLINDGLHEMIYNSIMKCDEDIRKDLFGNIVLSGGSTLFPGIDERIKKEITQLAPPNTEIEIIAPPERKYSTWIGGSILTSLFTFQKMWISKEEYEESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9V7</accession>
    <name>A0A9Q0L9V7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 17">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M0811_12626</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 17"/>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9V7"/>
    <dbReference type="OMA" id="DSPEGNN"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="19">
        <location>
            <begin position="106"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAJ5068040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="387" mass="46181" checksum="213FE4FB68044F5F" modified="2023-09-13" version="1">MEQSITVGSKVFCKFKFTDEYRLCEILSERTSSKNSQKEYYVHYEDFNRRLDEWVTIDRVDLSRIQAPEPEKNEVKQTEKRIKTHKRTRMRTRRMEKDEEVKEEMPRVKNIEAIEFGNWEIETWYFSPYPKPYTNSEKLYICEFCLKPNLSKEMLERHQTKCTTRFPPGNEIYRKDSLSVFELDGKHSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYILCECDDKGCHICGYFSKEKNSSYDYNLACILTLPPYQQRGFGKLLISLSYELTKRERKVGSPEKPLSDLGFVSYISYWATIIFPMIKEKENESISIQEISEKTGITHEDITLTLKHFSLILYKNGQYFINLDDQLFQKYIQKKKEAILIDPNCLFWVPHGKTTTRIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9X8</accession>
    <name>A0A9Q0L9X8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9X8"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022340">
        <property type="entry name" value="GPCR_GCR1_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02000">
        <property type="entry name" value="GCR1PLANT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="336" mass="38790" checksum="0A4191D4446D98EB" modified="2023-09-13" version="1">MSYRLLAGLTITSGILSMMGSIGIMATHIAYPSLRNLFRKLIFILSIYDFLLSFSFSLPGPSNDNLCSVQVVWISVMLGATPSWTASVSFITFLKIVFNTRDSFCNYLQKRLHVFTVFLSAVLCVIWIVFASPKKGGAYWCYTNESHLMWTVYSIWWFFLVILLIIYIFCLYKIRKVYKSVSNLARDSDKRRKKEKLKVQLRMTLIPLVYLVIAIPSTVKRFRELIKPDVSHSTTLDVLQAFLVPSQGIWDFLIFIVFVKSIRHQIISSLKRKWSKKNFDQTTINDTLLDEDEFLDANYISKSKSKSKSKSKSKSKITDLEDFTESESELNELDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA77</accession>
    <name>A0A9Q0LA77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA77"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040406090" evidence="2">
        <location>
            <begin position="21"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="737" mass="84066" checksum="67EF1CE23A985786" modified="2023-09-13" version="1">MKILLICFLILNFFIFFVKPEFTPTKSLYFPIRMYSIYLSLIDDNSGYVYFVDYDNNDHSFIFKFDAINFGFVDFLKFDVNFIDSGVYDKINKVGYFASDELSTIFKVDLNSMQVVDNITFGSGIFSFYAAQIDVFNQKAYFFSSSSNSTIFKIDLASFSVESNLSYAEEYMSASPLIDFSNGHLYFFSTTSASDPQIHKIKLSIFKEVGSLHLNTTSSSFLNTGFIDFSTEILYIAAQSDGMTIFRVDLITFTLMDNLTLNESYGNPMHSAVDIVTRMGYFLTDKGFFKMSLQNFSIIQSFLFDDYSVYSFSLDLDNQNLLFATSDSEIIEIGLESFTPKNQFSAKNIIQPTLILTDEVNQASYVAFDCGYGIIAKVDLSCFEVVGFLNTSNYDDYFSHGELDLDNDIGYFLMDSGLTILKVKLSNFSVIETKQIDANIYPELTVFDYQNHFLYVGCQNTSDFSSSFLKISVPDLQIVGNFELGSSDIYGLFIDVPLGFLYFLVENFSDPGTGYYLSQISLSSFNQISTVNLSDYEVSVSCFDPVHHSIFFEFVPFSNLNEYLNENEYENEYENLNENQNQNENQNENQNLNENQNLNEKQWAHFSKIDLSQMSISDSHIIQGIDDVIQCFVETTGTYLFFLSGFNLNQNVQIIQIDINSNQIVSNSTFNRSLDTFLFHFDYSSQLGYFSAYDNNPVPFIQVEVPHSNPNPPSSSEIINFSKIIFGLITIITIIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAE9</accession>
    <name>A0A9Q0LAE9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000123">
        <property type="protein sequence ID" value="KAJ5067973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAE9"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="533" mass="63259" checksum="311A7CC2F02F10FA" modified="2023-09-13" version="1">MIGYCNIKKGISYNNPGLILNALLRNFSSKPDFIEELIPNFPRKVPLITDRKITTRELIYQNINRRIFQEFGFDHENDTPNYSRNMMILTDKICNLSFILKEIEQLSTKTGYKLFFGSDFAENKKQTRIIRNLQSIEDSIRNGEIVILFKNEQLYEPLYDLLNQNYSKKDDNIFAKISFGNIVSKIKIDPKFRLIVISDKSRAYNIESPAILNRFEKYLLTSEEFITRNEFIRFYQKQKEIIQNICKFADITEEKLLVSYHPDLLPSLVTKLQQILSEKEQQEKEDYLRVEGVNMWMRICNYESILSIYLKTIKKIQTKIPKEISYLRYIWQRYLSLYHDSLNDLIQTTLIPKQIQCSVVLTSSSISQTIKSEQIQNFKFKEMKLSEIENDTQFEKEVKKNLGIEPIMKTNPYKDENFVLIIRFTPTSISPETIFHQSKYMIENLIKKGKEQKKDKKEKKNEEIKCKIIFVVHLPSIQQSKTQFHFAFEKNWEYFYIDDILPSEIKFPIISESKDSDLNFLENILDQRMGKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAN7</accession>
    <name>A0A9Q0LAN7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAN7"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68587" checksum="95A1550D8484DBAC" modified="2023-09-13" version="1">MNDCLFFGLNQNPILIKNEPTEITKPIQFKFENENENENENENEKQIKQISSGYFATIFLFKNGKAIEYLKDSNQNPSKIQIENIQKVTVGDENEAILTIEGNVFAKGYDINPKKPKEFINISSLIENTNDRIIEDIVSGSDSIYLLTSNHNVYGIGLNRSGQLGFDSETLKKTKKPILMMKNVSKIFSGNSSKHVFLLNSNQELFGCGDNQQSQLGLGKPLIYIIPKLTKIQNISKGKIIDIQCGFYHSIMLIEDENQNPKRKLYSCGFVKSNGLGKNQNTYEFTEIKSSLFKNDNILDFSVGNFHNLILTKKGKLVVFGSNEHGQLGTEERYTSYKPIQIELPELRFNENIFNYHISCGYNNSFLYYSLSSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNENQIEKLQEIISNKSIKESNQIFEMIYSNNSIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIKTKIDYFQLNQTNPNLFDLLINKFKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBG0</accession>
    <name>A0A9Q0LBG0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBG0"/>
    <dbReference type="OMA" id="DFEVEAM"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040281958" evidence="2">
        <location>
            <begin position="20"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="58742" checksum="ECEC9CCC0AB79C86" modified="2023-09-13" version="1">MNHFILLILFTFTISFVFCEEETTENIKFLNNKNFEEILTEKKYSLVVFYEPNSIEWKRFFPELKKTAEIITMLPDIVICAVDISQNRKLKNQFDIQKNLELKIFSFGTFLRNYLFAPEAPHLVAFLTKLHFPLVSKLTSLPQIQKFRTQFPFIGIGILSRDPKEQDRNEKIHSVFEDLAPHIDFSSMLFGVSITDLESDIAKEFNITQLPVFLLFRNLDNEILSLPLEPLSVELISEFFDQNQIPFIQELDESNFLFYLEYVSPLGILFLDYQNREEYLKIEKEVAKKFYPKMYFVWVNGEKVQSFAEKFGIHAPFPKFIILENLIQNKYIRFKSHKISENYLIQSVEDYFNNKTSYSTKSEKIPDNENRLVKKVVFKNWDEMITNSDKTIFLLLNTHWDEISQEIEQDYLKFASFMKENSNVLVAEFNLALNDFSQDLEFSEIPQLILIPKDKSKNIIFQKEFSFENFIEFAKENGIKEFTQKEDRKDFKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBR8</accession>
    <name>A0A9Q0LBR8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBR8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="9408" checksum="B5F749A1C34C6819" modified="2023-09-13" version="1">MNTYFHKSSQNISPFYLKNESKPKTKTNYKNLKNFNKNIRNKFYQYLIKTSDIQIYCGIDKRILYCHKSILTARSLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBW1</accession>
    <name>A0A9Q0LBW1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60s ribosomal protein l34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBW1"/>
    <dbReference type="OMA" id="RCHKCVR"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="138" mass="16542" checksum="25A1EF4EF45A33BC" modified="2023-09-13" version="1">MKRLTYRRRHPYNTKSNRVKVVRTPGDRHIYHYVKKRVKGRRCGVTGVTLHGLPHLRTLESRRHPKRDKKVYRAYGGCLSANTVRDRIIRSFLKEEQTYIKKLITQEKKEEMKQIKEKKKVAKKQTKKTKKTNKKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBY5</accession>
    <name>A0A9Q0LBY5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBY5"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="270" mass="31799" checksum="D9BB49A61FB8C6E3" modified="2023-09-13" version="1">MEKFFPDNLDNLEEMCELNGSTKPKKMKDKETNKIFVLKKGKSKEHCLNEFVANQIYEKANAQVPKMKKFETENDFQILIEFIDGITWKEYQEKNSKSPEKLEKIQREVMKHFVLDCLLANWDVAGLQDENIMIENSTEKPFRIDFGGALSYRAMGEKKKVEEWTGDFVPEIFTMLDSSFNETSARLFKFVSDLDIISQVNELNHFFQNIHLIQDLSDNDRNILTQRFQFLKLTAMQKEQDLYSTNQNFNADDDFDSQLEKALQESMKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCP8</accession>
    <name>A0A9Q0LCP8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCP8"/>
    <dbReference type="OMA" id="TCWQLAR"/>
    <dbReference type="OrthoDB" id="10258046at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="220" mass="25709" checksum="16A3D96AF56847EA" modified="2023-09-13" version="1">MSSRKNKKRKEKSKEKSKKKSKTNKTEKLTKLFKKAEKFAKKTHIQDIERIDKRDHLVEKFDEFFKEYIYVVVASGFRGKTAAELLPKLEKCQGNKKKMLKHFKNKRKCEAISTVFQLKNDWENLRSSLTTVDSLKQFPLIGDVVKHHLARNIGLVTCAKPDLHLTRLAKKLKFKDVKSMVDFVASNFNYKPGTADFILWIYLSHNGEEQDCCYGGYELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDA3</accession>
    <name>A0A9Q0LDA3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caveolin-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDA3"/>
    <dbReference type="OMA" id="MELFTEC"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35465">
        <property type="entry name" value="CAVEOLIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35465:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040402844" evidence="2">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="214" mass="24635" checksum="B414B12B725414DE" modified="2023-09-13" version="1">MKNFLYFLLLYLLIIQFTNELETNLSPNLPLNNLEILPDVSHKFYLNNLTQNTKYEIKISYSSSNPTNFKMELFTECQCYPNEKESFTCVNEKIPKNGQRKLLNAEKVIFSVNSILQIEELIDETNCCGTVNSICHPFLNVLPLYDGFSHLENYEKRLIPINIILENLDPINIPVSCYPVIITAVILAILALILTPLLAKKIQNYSIKESKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDU8</accession>
    <name>A0A9Q0LDU8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U3 small nucleolar RNA-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDU8"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="500" mass="60482" checksum="E70379D6EE5C31FE" modified="2023-09-13" version="1">MILKKISQIYANSLQFHPENEDLWILSASFEFENNLNMNTSRKILQRALKTIPNSKKLWHEYFRMECIYVDQMNDENILNLDNNSLKPQKHSQQLKNFLNFAIPKIIFKNAIEKISNDIQFRADFIPISRTFSNSDSLIDEIYQSIQNDFPNLPKQFMLISERYFDEIILKKLQNENEFKKSFEFAKENYQKILEKNNSLEIWKYYILFHKKILSVTKITNNELINSILNNFQTWLYFNFKIKEANVFLLKNTKTKDEKEKEKEEYIRKIYQELIEKFGKNNWKIWQDFIEFEKKQNQFKSSSTIYWRAIKELPTHSQNQNNIETIKSFISTVQIKFKILKELIEILPEPKAVIEQKITKRKHRPTIKKSKIRIKFEDAKQNYENGILSKKNKDYQKAEELFKKSIELLANIQQIIEKNLNNNPKNKIHLNRMKELCINLEIKNRIKYSQLLRKNYLMNHLNYFKLQLNQQILHDKLKLKGYIELEMELFNKIKENIMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEL6</accession>
    <name>A0A9Q0LEL6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEL6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="108" mass="13031" checksum="9A8D8B5204E9712B" modified="2023-09-13" version="1">MDKLKQERDNDERTRMKQRFQKKEGLNEEKPAVTPVLIRLEKKTTKRFDSADFFRGELKEEDSQTQKIEPITNQKNKSKNEEKSKTEKQKSRFAKEIEIEEKKEQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFZ4</accession>
    <name>A0A9Q0LFZ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arrestin domain-containing protein d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_10629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFZ4"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="514"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5071145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="810" mass="93454" checksum="BFB1129C7F5C449E" modified="2023-09-13" version="1">MNIEKQNEIYEVLFDLPISPKHRSESVRRTHHEIEVFPKKNKEFGYKIILPNNWITDNDINEGSDQFPQWKLIGLFAPDLDPNAPFISVSATSLSFEIDLDDWIEFFCRRDGFQIFAKKWWDSPTKDLVLDIGAFKNQDSNTVVMRAMTFIQQDTLFTICGVSKSTQWDQYKNHFLIACASFELIEQKAEVEKYYPSWNGGNPFINFLVPTNWTIREQEDHPQNQTICEVQLLVGEDMLAYILVKAIPNENVTLVYLLEQAMEELDLSGFEIYGSPVFIPGKGFKGPFRFHGWVKGETYVDSFANAIDGYFGTGIIPGKVGDRIVEARVGFRYFENCIVSLYLISVTSSSDILLWMRSKKTFEMIRETLSTKNNSNDNNNNNNNNNNNNNDNDLQFQEHLLKDKNNINNIDITLNNLQKNQNKMQSGKSFVDKSTTKNESNRFERQQSLPVISKTKKNMNKKIIGKSAIDWPLQLELGIEVGLGWKLKIENILISGNDPRILSQVFEKPEWLENNLSQRCMNCRSTFTVRKRRHHCRNCGLIFCSSCTTKRLPIYKFGIETPSRVCDNCAGLLADGNLFKSTISLKKRIKPKKSYKWINCKEGSFISTKTWCSDPNQKTRFITYTLYSITNKSYSLKIEKRKKLNGIIQDTKIVSLSKEEKNNMFGKLTGEKTQIGGQIMNIEGRWYSCYVWKTITNENNQIERSQWVTDEIKFPIKTVAKDESKSSYSERIAIKLKDEVYIGDRFLSCIKYKGFTIDENGKKTNHLVWMSDSIPGGVVRVVSKSETDISLTTEIIDFQIEINEIAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG92</accession>
    <name>A0A9Q0LG92_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG92"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="538"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="686" mass="81296" checksum="70C361DE888AA6EB" modified="2023-09-13" version="1">MNKFPETNFEDIYDRKYLFSNTKWVEIIPKNQEKESLPSQRTETILYDHKLWIFGGGKTRTNVFDHFYTFDLRTHITTKIEPKPGFQYPEARWGHKKCVSNDRMYVFGGHGKNSYLNDLWEYNFEANEWKQIKGNGDIPPNRSDHTIVSYKNKEGKTTFFVYGGWDGDNNTFHKGGFYTFDPETKVWSKFYPSGYNSDSSPVSLHTCCVYGDSLYFYSGRSGGSRDLKKTFVYSIPENTWKKFEIYSWSENDTLYKNDPIYTELKQKKEHDLRIKLKEISHDNFSMYPNSSSSSSSESEFQFRPYSRKMRTNKKGLKPFRPSSRTVSTAVLFDNKMFVFGNFSEDDRNLYYLDLETHCWFQAQINQTHKELPNGRFGHDMIIYDNKIIVCFGIGSNFSGPFNSIYQIELEYPLVLDLKFFFYQFRNDIFDIQFNTWDNKTIRANKAFLSIRCKDVSLEQISSVFSSFSYKDVDDVLHYIYTGRYRQTRESKDEILKMAINLKLNHLENLCRCSSPIGINENRILQDMDQLYYTREKSFDFILDIDGKEILLHKFVLAARSELFRGMFLSVEDNSNRVQDYSGKSYESICALVEFLYRDEFTVNEKICFDLLGISEFFLLKGTKIEEICSRFIIFNNLITIENVLEIDEKARIYFLERLRNHTKKFILTNFEELKEQNPKIRKEHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHB5</accession>
    <name>A0A9Q0LHB5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box-like/wd repeat-containing protein tbl1xr1 isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHB5"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040205033" evidence="6">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="97" mass="10780" checksum="DA60F0304A77D262" modified="2023-09-13" version="1">MKLIILNGILLVYFLPLVLMISQQKSPVYSIAFSPDGEYLASGSFDKSIYIWSVKTGNVVRSYQDTAGIFEVSWSPNGDKIAGAFADHKIAILDFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHB7</accession>
    <name>A0A9Q0LHB7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dep domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055213">
        <property type="entry name" value="IML1_double_psi_beta_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23013">
        <property type="entry name" value="IML1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IML1 N-terminal double psi beta-barrel" evidence="3">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="2">
        <location>
            <begin position="103"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1486" mass="175061" checksum="81F1294E8973A507" modified="2023-09-13" version="1">MTFRTYTKTFAFTIHNISESQEIVLVKETAFSDKLELGSILEIYQRDQPEKSHLFTKIESFNKKKGHFQISIRKDIAKNFNFQTQQLILVNIIPHQTMSVESIEISTKDYHFTRSEMWKLQRNLSSSCVYQGQIIKFNQTRVKISKIIKNKERVKSGVINERTKFIFSSRSSHYIIMIQISQEMWHFDYNGDLLFEKTLYSFFTNLFQKWTKSSSNHCLSIFFFSRFESLNENQNENENEFMDLFIPIIICQPYLEFDKIMQKIQHQFQNFSNIISQMKNNSKNKNQNPILSTAKNGNILEAINIAINILENFSMNQDLRRSGEKILIVTPGSGVFHVEKELRKLTKNRIHYNGFFIEIVSVNQPSLSAVPLFIENAFDNENQQQKLKQTLPYWIHMSFSEIKNPKQNTPKKLFQENKMNNNSNNNSNSIFQKNNFQNSFMKDQDQDPAINFFETRNEQHEQNENIHKKNVDKSKTFFSFDHDSDFYPSLSGMNLEKNFETPKYFQIFGFGENMDQKTPKRLQSTDAFTSLWRKKHDENVFTQLCKFPEFVIQIQNKKKAINHKRTFSSDGIDDHDKVFDENNSGGLRRHPRFMSTPNLYKTAIQSENESDQDENSKQENQDDFPNTSTGYGNRTTDSNQKNEVSKFANDLDIPQNSERILLGGFANISENSLILPYKSIFPDYILRLSKEQRSRQITIQNMETIHSYQVTKNKSGFLKQKTERNQSKKSNNLEKEKFTPEKSKSAKKPNEKTDPKLSIGISRTGIQVPRQNSIDYLQTRRSYAGKRPPGLDEMEREKKNSANSVAQISRGMKGKSDKITAKSDSLSEIWDIRNRESPPELEISDLNPFQIESINTYFNRKNHQIFWNEISALSGDVFNFSIDKTLTNYQILAEPFLLPLSVDYFPDQNELNSEYTCSFYQLLNENSNCISINDLLIELVSQRLDQNFQISLSIISEYLQKTIYYLSKKNIFHKIICNYREQIIDVQSFSRNNYFISSKSLSFPNSQDPKKENVLFSENPNSIEKNIHQIRYIHLPTEKHTKTQQKENKKTLENSIKYPNTDPNKQKKTPFLRRIIQTSFLSSKENSNENLKENSKENSNENSKENLKENLKENLKENSNENLKENLKEKKENIDLTDDKQDGKAKIQKKLNSKSFIKPKNYQFFLYSPFTKEFNSKQIQFPNNFLNNFRWNQLDELICGNSKLFNSAQTRKIKYSLIPNEYNITLFQKSFAVFYQEWILQFVQQSAKEPSKIIFIEKKNKKSTRMMKVEFQNNPKNSRFEWIYLTIPPFFQESQNYHIEIQWIVASNFTITQFISDASRIAQNNGMKLVQVPYQTPSNYVKNCPFLITKFLELNFDCLSFFSKKFILIMLCKKLKFTVEFVPNSIDLANGIWWNDLVQQKNSYQFLDKQICLLDYSGDIFVFCSQFGFFCTLNCFNSFNQKKLKEDFLLEIVHKIDLFYQKFILFDKLLIQNFNSFPFKKIFENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHU0</accession>
    <name>A0A9Q0LHU0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHU0"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF4">
        <property type="entry name" value="PHR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="225" mass="25740" checksum="1A63F3A1B310710B" modified="2023-09-13" version="1">MNDCLFFGLNNKPILIKNEPEEITKPIQFKFKNENKNEKQIKQISSGRYSTIFLFKNGKAIEYLKDDLYDYLFKEEDEYESEDLNPSEIQIENIQKVTVGALNEAILTKEGNVFAKGNYINPKNRKEFINISSLIEDTNDRIIEDIVSGAYSIYLLTSNQNVYGIGSNEYGQLGFDSVTLYKAEKPILMMKNVSKIFSGIASIHVFLLNSNQKLFGCGDNYYGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI62</accession>
    <name>A0A9Q0LI62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI62"/>
    <dbReference type="OMA" id="YANITRH"/>
    <dbReference type="OrthoDB" id="10025474at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040291138" evidence="1">
        <location>
            <begin position="24"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="623" mass="73233" checksum="AC111B165AB7472F" modified="2023-09-13" version="1">MTFFKKLIFCFFFSFLLISNSFCQYNEIIQELSEKISSLQVKNDTKFNFPFEYQKPKGIYETWIHLNFHGNLFSQLLRNNFKVFDENGFVTAWINEILLESNKIGTIQLDKDQLLNSIKLETKFVDKTVDDPIIVYWIQEMKDDHYVTQHPNLVGTVEKLKQWSGETYHLLNSLGLKGLAEKIGRLHKKLQKEELHLQIPADADDTSVNLAMGCLLYENKDKFPDSFDTWWDANKNISGIMKYFLKYAYYPLSDDKNLNSIDPRSYYFMHEFLESGIVKEKDFGIVTTWFLNRNEYKENYPYRMMRYNINSVDASVCSNFIYGLSQLSVSKLIPLTEWMSDEIKKLYLDTSIFVDWTIKSGRLVERPDLGSLYYPPIYAMYWFTSRTLSLFSGNSFPDPVFETVYSMLLKTMQNEATKHILESAQEDDNYVWWDDFLGVNDTYFNGKYVNNAEDRIFTTSMAINTLIDTWTIRKNYKYSWRKETPDHIKKIIEKGINWLVKYSLSSKFKPENSFFSITVKSEESFPFYFPATFIEFVNGTTVSPNSSPSIISFELTPAMEGIVSKEEYNHMVYDEMHFQSRTPTHFSGFNLRPFFSWSSPAFTYSSTLFAISKYSSLIEKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LID9</accession>
    <name>A0A9Q0LID9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LID9"/>
    <dbReference type="OMA" id="HYILDYH"/>
    <dbReference type="OrthoDB" id="65740at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000039">
        <property type="entry name" value="Cysteine proteinase 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040257839" evidence="3">
        <location>
            <begin position="21"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="5">
        <location>
            <begin position="234"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="317"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="538" mass="60984" checksum="19390E770D16A3ED" modified="2023-09-13" version="1">MLKIFALTFTFCLLFSTTFGINPPVYPTKYRVTGIWQIPNGNVTEPILVNFDGDSDHERVDYYSMNITTALGTDIIRDDLNKTYELRIQQDHQGCTIFQNAGPSSTAVDSNLPNVLPNLTDSAWVYMGESVVRGIHCYYWQMNITEYNKSNSYTFYTDADGNPVRYLLHGYNIVFHSHYDIYILDYYSYEPNVNDANCYDIPPICNSTETVYSDKVAPVPLRALVSGLRNSRSFNSYVNEYNKDYTGNEYEKRKLIYEENLRRIDELNSQRSFKLAPNHFADLTLEEFKSLMLPKKYSEINVQLKNAVPYQRQNLDLPDSFSWLDYGAVSLVKDQGVCGSCWSFATTGATEGAYFLATGKMETFSEQALMACSWAEGNSACEGGMMYGAYDWMTQNGLTTEELYPYLCMDSYCGYDKSMQKIGVSHYLNVSVSGDIELTKEMLYANGPLAIAIDAGHFDFVYYQSGIYSSKDCHSDFDGLDHGVLLVGWGEEDGTPFWIIKNSWSELWGDKGYCKMAQANNMCGVCTVPSVPVITTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIQ0</accession>
    <name>A0A9Q0LIQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIQ0"/>
    <dbReference type="OMA" id="YYNNIVT"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="2">
        <location>
            <begin position="282"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="505" mass="59249" checksum="2059310BBE7ACE77" modified="2023-09-13" version="1">MSLSVKQINNIFQEIISNKKNINKITLLFDSIQDQKSEDLIIFTSINKLKKIFENFFKTQELNTNQKLFKNKEETPQIIFEKWLYEKFKLYLETLLDLLQNPQPRIQVPSLKYLMFFIKIEAQQNNEFNLKLFVNLIKRMLFSPNLSELVIEEFKNYVNFDDIKLYTMKSLNSIIQNEISKDSKKANFVLNAFPLIETIPVPEEEVNSFYAEIPQQPNITSTTFHKKEYNKMWLNYLKLDIPNTILKQILKEMDTKIIPHLRDPILITDFLMKCYDKSGIISILALKGIFVLMTEHGIEFPQFYTKLYAILQHDIFYQDEVSEFWVLLDVFLSSLIMPSYLAAAFAKRLARITLDAPPSGCLVAIPLIMNILIRYPSCRVLVDETLAIQEEKLSLIQTNDPYLFYEKNPEKSCALQSSLWEIKTLQKHYLPQVARLACSIEQISFDSSNLYNIIDLIDFSYKILFDSEISKKTKKDPSINFISQNQLFDPKNDSLKVMQMFSFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ75</accession>
    <name>A0A9Q0LJ75_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ75"/>
    <dbReference type="OrthoDB" id="6418787at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="261" mass="31103" checksum="7CAFF6D82F6FABD6" modified="2023-09-13" version="1">MNLNNLNNLNKIKHHFQLINSIYSLRNSSNSFQNFTILTGKNLIKIYSHKLILSCRSSYFYQIFKQNPSLNEISFPEINETIMNLILDYIYKGEIDFNERNVFKIWNISQKFELNDLSNSIQTYLESNIQLSNVFKIFRKSKSNSKLNHQSFDFIIQNFEKLIPFISKSKLSEEQMKEIVEKSFINNQNLQIFSLLNELTNWAELIQQKILPKNPKFDKKAKIILMKKIIKPFFKILPINLLNEKEFYQLQSKIGFNQNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJJ8</accession>
    <name>A0A9Q0LJJ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJJ8"/>
    <dbReference type="OMA" id="WINEEST"/>
    <dbReference type="OrthoDB" id="427974at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051550">
        <property type="entry name" value="SCF-Subunits/Alg-Epimerases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990">
        <property type="entry name" value="F-BOX ONLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22990:SF15">
        <property type="entry name" value="F-BOX ONLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Carbohydrate-binding/sugar hydrolysis" evidence="5">
        <location>
            <begin position="473"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate-binding/sugar hydrolysis" evidence="5">
        <location>
            <begin position="631"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate-binding/sugar hydrolysis" evidence="5">
        <location>
            <begin position="774"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate-binding/sugar hydrolysis" evidence="5">
        <location>
            <begin position="906"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1078" mass="118922" checksum="3C7C99F8EADB48C7" modified="2023-09-13" version="1">MQSLDELLASLNNSLTTNESEISNNSQSNINMRNESANSLDDLLESLNRNSQENSQNPNLEIPDLNQLSGNSNSTQKDDLDSLLDSLKFEQIPKQNSNDLQQKDQNTQDLDDLLDSLDGLQNPNQNPNPNPNLNFNPNPNLNQNTNFNLNQFGNQNFSPNKFDFGNSPTIRKNTQQNPYDFQNTQSPNIKTNYETQFTTPTKTTENMRMNSIDQLLQGNYGQTSPNPSNITTQTGGIDGNFDNLLKSLGISQISRPNQTTTTNFQPNSFSNLTPRQSSFTTGLSSPVQPPRTVSTGLTNVDELIKSLSQNTPTQNFSRNPSFLSGIQTPNSELKTSGFISQRQEVNNEIESADDFLNKLKSAKNPQFSPQILDQKNEQENTQNTDKDSNFEHMWENGTTYDVDCNGIHSKYSKISDIYEQMSSGDTIRVFPGIYHESMEIKKGIRIIGFGQKNQVVFENPEAEYDKPIFQFHSSFGSLKNIYIKYSGIDTGIKLFTGTVTIEGCTISSQGVSGITAESGAQPQIKDCVISGCKQVGVLILSNSTAGKLENNTFSDNLISDIEIKTEASPTIIGNILRSGITVHDHATGRIENNKFLKCPKNGLTVMNFASPNVVNNVVQECGYFGVFICQRAKGVFEKNTVIGNQKANFGISSEADPVIRDNQILQSAGFGIWCFETAMGEIESNEIRGNGEAGILISTGSDPKILRNLISEQKKNGVFIFQNCQGRLERNKIFQNNGHGVEIKKAASPTLDFNEIYKNKGAGVLVSEYSKPTITNNEIFMNYKPNLVVTSHSEPSVERNHIYDGFQSGILVIDSKGVFSSNELDGNQFSGAEIKSKSEPIFKQNKFHDCQAYGIWINEESTGVFQENEFTNNKNYSIFITNSSNPQILSNTITKGEKSGICVQGPSAGVFSKNNISAHQQPEVVLKNGATSVFFDNKIHHSKQSGFFITDQSHCTITENQIFNNTLSGIEINMMSFPVIEKNKIFDGQSSGILIHQKAGGTIKENEIYCNCGPAITIGESAAPNIVQNWIHDGQSCGIKAMKAAKGNVTLNKIVRNNGGALTVLPNCFTKFVKNELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJM1</accession>
    <name>A0A9Q0LJM1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Wd40 repeat protein swd2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJM1"/>
    <dbReference type="OMA" id="KICVLNG"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="327" mass="37497" checksum="2F0C7E9A2D820B45" modified="2023-09-13" version="1">MEQEITEEVLKSMRVGHSFHEEGPLISSMEFQENGEKLVVARTDSSISIYDCLNPKHENKIFCKKYGVEIIKWIGYGNTVLCSSKPPTGNDHSIRFLSLHDNKYIRFFKGHTEKVLSIAPSLRDDFFISSSLDKSVLVWDLRTPSLVGQINAKIDDPFVAFDPAGVVFGVATTLFKNGIYQPQIKLFDLRKIEKGPFGFFDLDIQFPAKSPKYQWTSFQFNHKQTHILLSTNSNYVLLINPLNGQITQIFNSRSNKQFENIEACFTPDSKFILSGSDDGNITFWGVEEKQEIPVMQYNQELIRFTKFNPVYLMFAEGNSTLNFWIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJN5</accession>
    <name>A0A9Q0LJN5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJN5"/>
    <dbReference type="OrthoDB" id="413653at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="30309" checksum="698F5636ED9A4EB0" modified="2023-09-13" version="1">MQNIPVELYKEQIKTWPEKGKHIMANYDEESVIVYQAFNKEIAEGAVKNNEFKEENGYSLSRMTWIKTEFLWMMHRSGWGHKKNQEKILAIRIKREGFEKILELSIPTMFKEATFKFKSKSEWEKAVAKAKKQESYVCVQFDPAWNPLDSKVSKRRAIQLGLKGDIASHFRSDFIVKIYDITSFVHDCYSNHVLVKNIESLKIPLEKEYPLDENLRKHLGIGKEFEEPEKEDADEDDFANYQKDVKDFETNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJP5</accession>
    <name>A0A9Q0LJP5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJP5"/>
    <dbReference type="OMA" id="NDIEHHY"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF79">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="45"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="196" mass="23081" checksum="ED83276E6E02375D" modified="2023-09-13" version="1">MDDFGSPSFWEDKYKKSNYIYEWYMDLNFFFPKIENFVSSESVILNVGCGNSSLCQQLLDKGVKKITNIDVSQEILDKLQSSINEKDSVQFIKMNAKKMQFEDDTFDLIFDKGLIDSILCSKNFKKKVYKYLKEIKRVLKPNGYFFILSHSSPEQRLIYLTDSRLRWEVTTVSIPQKKFNGITRNYFLYILDPGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK66</accession>
    <name>A0A9Q0LK66_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_00961</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK66"/>
    <dbReference type="OMA" id="DYNKNQP"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5074332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="475" mass="56038" checksum="E0B4BD4F1584F555" modified="2023-09-13" version="1">MTTDQLIPYANVNLIRPEEYSDIDNLKLEWGNQDNYAVLQKIGHGKYSEVFLAIETNTEKECVIKILKPVDKRRIKREIKILQNLHGGSNIIQLYDIVRDPVNWIPSLVFESVQSVDFTVLYPMLEENDAKFYMFELLKAIDYAHSNGIMHRDIKPQNIVIDHNLRKLRLIDWGLADFYYPGKDYNVRVASRYFKPPELLLGYQRYDYSLDIWSFACVFAGLIFQREPFFRGRDNFDQMAKIARILGTDDLYDYLEKFDIDLNPQLEVAIGVHSKKKWSRFVNPDNRHLATLDAIDLLDHLLVYDHTKRLSAKSAMNHFYFNSLRPKIENLDENENEIKIQNENQNENQNNENQNDENQNNQNNENQNENNENQNENENENFSDSEFTENLDSKWGIPEETQDNTETYSIDSQFQDQEFSNSFSSLQINQNQNQNQNEIQNQNQNQNQNQNQNQKSHSSKKAKMKTIFKRLFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKT5</accession>
    <name>A0A9Q0LKT5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thap domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKT5"/>
    <dbReference type="OrthoDB" id="7331812at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="6">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="5">
        <location>
            <begin position="199"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="817" mass="96899" checksum="9319CCD7BC3D91A1" modified="2023-09-13" version="1">MSNKKTYQKRIEKDCLIKVHGETFKKLEKMLIEKETWNHLIQRILTRLSEFSLKEQLKQNEVDEKNNISFLDSLLNDDSQLKDLTGLSRGSFTEVLKKVEQENEKTRSEKKSPNKQTKKLSIPHILLMTLIWLKHALSFGALAAFFKISKTTVSRYLHFMIEILRTVLEDQIRWPNEDEMKRNNEIWETDKILDCAGVLDCTDHPRVRHGKKEKLYWSFKRGGSTIKSVVVCDPVGKIIFFQTGFPGSIHDSNCVWFSKLIPILKNKKVLGDKAFHRDYAITPHKETQTGLTQKEKEENQIIQHHRSVIENVFSILKNFKISKSPLKIDVIFHGYVMEVCAFLYNLEYSDHPLRKQNRTKKEQERVDRKREQNHQRNSIKKAERERKEREKEEKEKESQEKEKAKSLSQKTQKKKPKKQQKKKRKNPQLESKSQKAKKKTGVRKKAGKMNLIEQEIEEEIEDGEEINDQKETAPNDPNYQECQEIQNTLNRVLEERILQNQLRFFHGGIEEDWEDRTDINGWVDMSDMKNLLELICPSYSSIEIDFLRSLLLPSINFYRSLGKNQNEIQEKLIQIDQNFKNWFLECYRNRYRQTILFQFQSYNEFVKKNFLDENLFNFLSMCGLGFDIILDKERYEMLKELTHFTKQLSKKRDLENILFLFQKAKEQKGRIFLPFWTPNHYLCYVLDFEKLSLSFFNSFGHKAQIADPLGIRIRNFCEEILNIKLTFSIILKQPRQIGATQCGPFVIFFIWMVTEMGVELEKVEQIIRQDLVIKLRYFLLISYIKASQSKKKTISLYRLNSLLKKNSTGKNIKSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKU9</accession>
    <name>A0A9Q0LKU9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKU9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="131" mass="16038" checksum="6674224D3DD91A34" modified="2023-09-13" version="1">MNSNKNQNFLKNQIDFQNQIQNEIEFLNQNNNQNNFLTEFLNQNQNQNQNQNQNQNQNQNQFINQNQNQNQNQNQNQNQNQNRFINQNQFINQNQNQNQFINQNQNQFINQNQNQFKNQNQKIKIKIKINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL98</accession>
    <name>A0A9Q0LL98_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-phosphatidylinositol 3-phosphate 5-kinase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL98"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052742">
        <property type="term" value="F:phosphatidylinositol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="95" mass="11407" checksum="945024FCF05D58A8" modified="2023-09-13" version="1">MKVMDYSLLVGIDDKNHQIIIVVIDYLRQYTWDKQLESWVKRTGLVGGGQKAKPQLLFSPEDYKNRFQKYIQKYFQILPTKFTVFDPSEKFERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMX3</accession>
    <name>A0A9Q0LMX3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMX3"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="418"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="70529" checksum="C87314ED051CB33A" modified="2023-09-13" version="1">MESQIQIKIKPIAVLELKLPELSYWKMNMISTDEKNNFLFIAIKRNDPKVRGGNTINQIRRGWFGTMQVLIAVGEEGMINIFSIGSKKEICFFGSRPLCFQNKEESTWSIATNSRNKILAIGSNSHNINLWKLSKSTIQVENQEFVGHDHNLPSIDINQDGTLICSASIDTTCRVWDINSAREVFKHSYSDEWGWGIRFIKDENVPLIKISSKKLTTFIQQKNRDFGYQFGEGSIVNTTRNRINREDALRALQGDHRQVANFLLNLVGNQDPQLERILRMQVLRNVRWENLRNRVQQNDINEDINEDINEDINEDINEDINRDINEDINHINEIINQTDSDVDNETDSENQIQSQSELETEIELEFEIGNQFDNGNQSQGESGNESEYEYENEFNFEFEVEAETEPEPETETEPESVVEILNQNQNENEIQNQNQNENEIQNQNQNQNENEIQNQNQNQNQNENEIQNQNQNQNQNQNQIENQNEIQNQNQNENQNQNQNEIQNQNQNQNQNQNEIENENEIQNLNEIQNQNEIQNLNEIQNEIQIQNQNEIENQYQNQNQNQNQNQIENQNQNQNQNQNQNQNQIENEINNLIPSDFRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN41</accession>
    <name>A0A9Q0LN41_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_06709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN41"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="12">
        <location>
            <begin position="231"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="58686" checksum="73D47A24DEBBDE6E" modified="2023-09-13" version="1">MEYFKRLPKFIQIIFIFILIGQFIIFIILNNQISSKNNLLNEKEIILIKNENENENEIICENKIICKNKCENINKENNTLPKSFQIIKEIDSEITRRCSERFGDLFIKNWRETQINICSGYGLSHIQCYKRENSPKPQLLCVAENSEIRGYSPYYIADSSDISKITHVEINKGFLHVDCDDSMRKWIPETEWEEKLNFVMGNMETNSDIKCEHWINHTVFWIWRWAEAVTYHFFEDFITVFFQLLVLNEDPQNVQPVFIDDIARGPQLYDFWSVLFGYEPKILRVDPFPKNTCFKKSIFGMSASFSIWYMELWQISEKKCKFPMLYALKNYIFERSNISFDNHIHKSPYTIAFVKRENYNGTIIKRTIPNYDNVSNYIEQKLPKNWKIVKFQPEKMTIPEQIQFSSNISIIIGPHGSALTYLLFMPEHSHLIEIFGGNRSPNMGHYKNICTYLNHEYHNAGYFNDDVSEKEIWSLVSESIQKIEEIKYQNQFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LND0</accession>
    <name>A0A9Q0LND0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LND0"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="145"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="313"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="382" mass="43479" checksum="71635EEEC5D70830" modified="2023-09-13" version="1">MNDCLFFGSNQLPTIFENELNKITKTIQFENENENENENEKQIKQISTGCFSTIFLFENGKAIEYVTENPSKIKIEENIQKVTVGCSNEAILTIEGNVFVKEEDINPQNPNEFINISSLIEDTNDRIIEDIVSGANSIYLLTSNQNIYGIGSNEYGQLGFDSKTLEETEKPILMMKNVSKIFSGNSSYHIFLLNSNQELFGCGNNEYGQVGLGESKKEETKIQKLTKIQNIPKGKIIDIQCGMFHSIMLIEDQNENENPKRKLYSCGDSQFNGLGRREDTYEFTEIKSSLFENDYIIEISVGCDHTLILAYNSKLIGFGDNSYGQLGIEDTRLESTPIQIELPKLRFNENISNYHVSCGYYESFLYYSPFLSNLEEDLIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNP2</accession>
    <name>A0A9Q0LNP2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNP2"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="272"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="326"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="47043" checksum="6A7D913CF7C6B921" modified="2023-09-13" version="1">MNDCLFFGDNNYPILIKNEPDKITKPIKFKFENENENENENENENENENEKQIKQISSSWISTIFLFKNGKTIEYLRDSKQKPSKIQIENIQKVTVGYSNEAILTKEGNVFAKGKDIYTNNPKEFINISSLIEDKNDRIIEDIVSGAYSIYLLASNQNAYGIGSNYSGQLGFDSETLKKTEKPILIMKNVSKIFSGNTSAFVFLLNSNQELFGCGWNQSGQLGLRKSIKETEIHKLTKIQNIPKGKITDIQCGHSHSIMLIEEDDENQNPKRKLYSCGVGFYNGLGKNKDTYEFTEIKSSLFENDDDNILDFSVGYSHTLILTSNSKLIVFGYNYYGQLGTGDTNDQSIPIQIELPKLRFNEDISNYHIYCGYYNSFIYYSPPSFSNLEEDLIKLFERKEFCDISFKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP66</accession>
    <name>A0A9Q0LP66_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP66"/>
    <dbReference type="OMA" id="WIVIGAP"/>
    <dbReference type="OrthoDB" id="447633at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040407391" evidence="6">
        <location>
            <begin position="18"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="474" mass="51379" checksum="CE69ABE0B530DA89" modified="2023-09-13" version="1">MKLIFIILVLLIHKISTNNTPFQYEHLLSANDPNNYIYFGQSISISGNTLAVGAGSNFYPDGAKPGRAYIFEQEKSNWNQKARLFASDGTNGDGFGESISISNDIVVIGAPNANVGNNTYQGKAYVFKKNGTDWNQVAELIASDGEAEDLFGYRVFISGKIIAIGSPNSNISGNSDQGCAYVFNGNEDGTIWNQTQKLIASDGEVADYFGEMISISSDSSLIVIGVIGADVGTNQNQGKTYIFQNNGTYWNQIQILTASDGQAGENFGSTTSISSDSSWMIIGAPSAKVGSNGYQGKAYIFQNNGNQWNQFQILTASDGQAYDLFGYSSSISIDSYWIVIGAPNTDSQNMNPQGKVYIFQKNGNQWDQVQILQRKSGDSSLFGLSLLISDSFVMVGSPGSDSSNGKYTESGNVYLINNTPLSSSSSKTTVIVCSTVIPVVVIVGVILTVFFIRKRRKRKQEQNSEEYSKLTQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP68</accession>
    <name>A0A9Q0LP68_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sesquipedalian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_07697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="628"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="734"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="1273"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1093"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="324"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1103"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5074993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1318" mass="153083" checksum="6F678169D6130F3E" modified="2023-09-13" version="1">MNPQNQNQNLKNSIQKSFGNSKINLERNNKTKFEKNFNQSLINNNNNNNINKSPQNNSNKTFKNNINKSPQNNPNKSFKNNNSNKTFQNNSNKSFNNNINKSLQNSPNKTFKNNNSNKTFKNNSNKSFNNNNINKSPQNNPNKTFKNNNSNKTFKNNNSNKSFNNNPNKTFHNNNINKSPQNNLNTPFKNNPNKSPQNNPNKTFKNNINNQNNPNKTFKNNPNKSFNNNPNKTFNNNNNNINKSPQNNPNKSFKNKPNPLSKATSLQSHSNLNNLNTPFKNNSNLQNQNNNNHNINKSPQNNLNKSFKNKPNPLSKATSLQSHSKSNLNSNKSNQNNKNKSFNNNNNINKSFNNNNINKSPQNNPNKTFKNNINKSPQNNPNKTFKNNINNQNNSNKSFKNNPNLQNQNNNNNNINKSPQNNLNKTFKNKPNPLSKATSFQSYSNLNNLNTPFKNNSNLQNQNNNNNKINKSPQNNPNKPFQNNINKSPHNINKSFKNKPNLLSKATSLQSHSNSNLNPNKSFKNKPNPLSKATSFQSHLNQNNLNIPFKNNNNNNIQNQNNKNNLNKSFKNNQEINLQTETVETDGEEDIENENENENENEIQKQKQIQLQNLTKTKSTLNILEQIQIKKNGWLKKQGAVHKNWKTRFFILTKECTMIYFKTDNNFTNPLGVISLIGAYCFKHKKKNRFQIYHSERRTFYFQCESEESRQSWIDSIQQTILESQPFRKGKDVFQKFKGYIQKQGLTYKTWKVRYFILYDYVLCYYKNEFELEIPFGMISLAGMQIQEEYNEEIKQKIIRLHHPLSRDFFLFPLTAPLAQNADLDHLKTQIDLAKDATQKESLRQIFRQKYEDFMVASWKQVLIEQIEISNSAQLHIAPNLPINFDSQPKEAVDGFMILREYGNKQPYGRKSLWFVLNGSYLCYSLKRKAKNKMKGAFSLQDVQIIGTRSRVAKPFLITITHPRRKKIVLEVDEYSDYSKWIKSISEAAFRSKSDSRFWKDFKMEGFVSKFLKKKKIFARRFMKIQNHCIYYYSPPFDTLRNPSNIIKLNGAELIPFDTINFIQWIKAIEVSITNADGIDFNDLDILKNPEDFLPNDSSNNPNEDHFHHSENTDLETDSNSEQQNNTSDTNTNNPQNPFSLSQNTIENFIAITNFSEYELKLMFSRFSKKFKQETMSRKQFNVLAKEMGISLQPKIDLLFAGFDRFKKGKISFEDLVIALNSLTRGSIDDKIHFSFCVYDRANLGKIDSKSFSETVKILFSLRLEKDKISKSELKKQSQQIFSNFDKDQDGFLSFEEFKNAVSLNPVIVECLGFFRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP86</accession>
    <name>A0A9Q0LP86_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP86"/>
    <dbReference type="OMA" id="WIINNTD"/>
    <dbReference type="OrthoDB" id="10263533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="704" mass="82157" checksum="306F13CE1F18F674" modified="2023-09-13" version="1">MFEWVFILISSTLFPFIFIYNFFYKTPFYLLECIAISFPIGIALSSFFSFYIGVFFQIYLSKSHSWIVSLFFFTLTLIELNFFRNQKRNQNQNQKRNQNQNENQNQNQNQNQNENQNKNQNQNETIIKQLINEIYTNGTFSIALFALMILFIYLFHIHFLRYTPDGRYTAMNGFADLPFHENIINSFIHGANSKWKGMNNLKTLFYSNEKFVYPIICNYHTALLVGAGQGGLREMLIIPSIMMIFSFIILLYFLNLRIFKSKNGAVISLFMFFFSGGLGFITFLKKLLTGNDVNLDNLNYVQWIDKGKEYFWWNPVDAMLINQRTSLFGYPIVISIFILLWIILTVDLKTTDFIKYAKAFSLAGFLTGILPLIHLHCFFAVAFVSILLCIFFFPITKPNQWIKYITSWSVFGIVSNIIAFPQLLMFFKRATKEGFAKISPVWIGENTNPFSYLFKALGILLILSIIGIIFLNSKQIKFYISTLLLAIFGWIVLLQPWKFDNMKILQIWFFVASGVAANTLVRCWPPSYIKNEKPLIKFMKTISIFFIIIIFISSIFSGYISVLRLPMKIAGLHSNEDYIVGNWIINNTDADSIFFTDNDYHASPVSTIAGRQIYFGFVGWSMNHGIDYVKRERKKNEMMRLLDDLENQEKADKFNQILDEEKISYIYLTGYRKLSDSVMENLDLKEVLSVSHITVIQRLYPHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPQ5</accession>
    <name>A0A9Q0LPQ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thump domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPQ5"/>
    <dbReference type="OMA" id="MNEKACV"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="4">
        <location>
            <begin position="164"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="297" mass="34632" checksum="6ECF57CE5847D083" modified="2023-09-13" version="1">MESKNKSKDKYKKKRKYLGANNPKKRKNLHEIKQGIYVACDFGTEALCVLECFVLFNQVVEKIYPEFKKENLKENLNENSNENSNENLNENLNENLNEVSESFENELAELRGNKGDDKKTLYLFHSIRMGGHGVVFIEISDEYLVQKKIQISSEKIVQEIMYQIEKTGKLQTKHASRIVPFSKICYADMETILLNAKQIVDEYFNPKEKLPINYALDVRVSMGKFDKKQLIKNVADLIDAKHKVNLDNPDVVFLIHIFKNSCCFGILENYTRFAKFNVRKLSEKILSQKENEKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQH8</accession>
    <name>A0A9Q0LQH8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Klaroid isoform a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_00438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQH8"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="714"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="361"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="486"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="889" mass="104156" checksum="3809D65543978F66" modified="2023-09-13" version="1">MAIQFFLDLISKILSFFVIVINEIRGFFRIFLTFTFLIFSFFCFIDEMFAVFLQKFFSFFARGNVQKVLLVLFLFSGVFFAIDKDVIGPQVQNSNLVPFSQEIIHEYTISNVELFMNETTLSNTVSNIYEIIKKQIWNEITKFEQSYLIKKKEENKENIVDPEVYRPLFKQRITEILDSDPIVQKNLQTLKKQIGSLKKDVSNLVYIFNNTEGLIQFDKKKFEEQMRNIETIIEQLDKNQTVTDLQKKVFLTKSEFFYLFQNKQLNDTFKRINDTHQYIDSLHGFTEKGILETNQFMDNLKNRKNIAEDNIQSVIAQMKQILEAKSKDSPEMDLLKKKLQEFMQEFYEKSLQFDENFNQISDQIQNDYKNFEEKQKDFNNQISNLQNKITSQKDLPQMKADVEKIKKEMEKEMKEFISKTRNQMQKIQKVSIFHDQNWNKTATQLAQLQKEIPDKEFIGESKNTLSQNIEKIKAQSLVTDSFNSEIDILEGKINELNTIHDQIKEKIDVVMEEVNKILSRKKLLEELINEDLDKYKLEAEKLNNILDSLSTAENKELVLQKIKEMEDTLASLENQISGINEQRNTSNRNFREVWDLMNKINKSIEEFNTDDNSDKFRPNITNIDNEKTQELEETRKKNKQDLRDQILQALPSLDSQNKKLIKHFIEKYIDQKDPFNQEILNPAFKEFLDKLHLDKKTVDFLMTNIENNFVCSVDFAQTIISKSPTFIPPIQNDFVDNFKKLTQISLVPIREFFTQIPLLQRTKDPRYCWSFSGYKGFLIIELSHLITPKNFTLEHISSSVSPLHPSSTAPKSFTVLGSSDSSFTNPVSLGHFQFDNNGSPIQTFPVNLDSDSISPQISFVKLEIDSNYGADYTSICRFRVHGIPVKIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRY9</accession>
    <name>A0A9Q0LRY9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_05725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRY9"/>
    <dbReference type="OMA" id="CFFFLWF"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="149"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5077626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="375" mass="43597" checksum="2FBDF0923A9D369E" modified="2023-09-13" version="1">MEIYSSYEFDKINSSRHSKRRLYEIYPGKNTFCCKGSISTGPDIKKLIGALLLYNLPIFIFLGLQIYWIHQKNSQNEKYINWIDSHFNLKASLFFSFLFWFLTNLFLLLTSFVDPGVIQRKPFSNNGKNENENSNSKPDSCHIKHIKLEKVYCVTCNIYRPPRTSHCSNCNNCVMVFDHHCPWVGTDIGLRNYRFFASFLFSVLTTSIYTTALCAFFLISIVYDFFQKKHQQTGYPLYLALSFSLSLISLGFGIFGIYAILSLVKLHCFLISKNLTTREYLKDIYVGTDNPFDNGCLSNWKEKFCTKIPPKQINYRAFATHKEITSLENQLEENRGGFLGSKKAKEILKQEAEKIRIEFEVIDTPHMNGEWIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSK8</accession>
    <name>A0A9Q0LSK8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSK8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="133"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="239" mass="27730" checksum="9F1A129B0702D770" modified="2023-09-13" version="1">MELFFDEQALSLMELYSSFRNDMVVLYERKEKCDLIFQATNGSIPVHSSILFARLNNIPIETLSKVFGFREKREIDIFFKWIYGGLIDSNEENDIINEIGIEIGLNEELIKQKTGIDKLKEEISFLYFDDEGKDFTIISGDSSVKIHSSMLLARSDLYRGMLLMCNDDSNKVTDYSGLSIQALQTLIHFIYFDEILENVPISVLKELKYIEDYFQLSLSSSLVLKINEILEERKLEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT20</accession>
    <name>A0A9Q0LT20_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_05892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT20"/>
    <dbReference type="OrthoDB" id="74575at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043556">
        <property type="entry name" value="StARD5/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46374">
        <property type="entry name" value="PROTEIN CBG07384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46374:SF1">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="295" mass="34484" checksum="B5FC589F7AAE5139" modified="2023-09-13" version="1">MTDSDDKIIKEARETAEIVLQDSLDESDKWEKQKSKDAKTTVFKKIIEKNPVHRFKALTIIENTTPLEIRNLLYDIKKRLKWDKETKSIEVLKCYDEETKTELCHTITNKVYKGLISSRNFFDVRSFIPFENGIIVNSGKSVSAPKKKIKGVLGNNFPSGFVMIPIYEEKENKEKEKENDIKIEKQDDNQENKEKENKEKEKEKEEEKQKENDIKIEKKDDNQEKENEKENKNQTQINEKKIIATKVCYIVQSDIKGYISYGLVNRAVPSVLVDGLNNLRNFLSKEKEETQNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTK6</accession>
    <name>A0A9Q0LTK6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bicd family-like cargo adapter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTK6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006933">
        <property type="entry name" value="HAP1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04849">
        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAP1 N-terminal" evidence="2">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="555" mass="65787" checksum="095A65303570F226" modified="2023-09-13" version="1">MSKSTPISPIQTPIHHNFLTPKKINKESYQKFLDQFWKNGQKSNEITRSQTKTIQNQLQEIEQLLCEREHDLLLAAQIGQSLLQTNYSLESKVENYSILLEKEESKKADLISENNQLFEELKKCENQNHKLEFEINKLRKENKNLTEDHENLFKDFQKMEENQKKFLTQTFAFSEVRKNDLKSYDENYLQKKLMKISRLKSELENAQNENLRLRHQQIQNKELKNKISELEHENQFLSNELSEANMKVKQVQNQVLILRDGSVKKLQYQQLESQFKEVTKSLEALQLSQITLEERINNDMNIIQNQREEISRLERINQEPPLVEERKPILKNSLFSEVRKVHPLKSTLFNQNFLDQTNHVNEKNPDQKNERENNLSILDSNQQTKQFPRSQVSQKLKMSSFDFENRIESEKICSEPNIPKKFQDSKQFFNLENLNQSISQIFQGNDSELFCNFLKRFNKSNIRYLNLRLSNEMKSLQSFSDHFLLLVEKCNSQLDDLIGDCSNFQKKINQNSGGFLIAKLFIENCQSMKDINILASKLYEPVFKKIEKFTHFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTW1</accession>
    <name>A0A9Q0LTW1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTW1"/>
    <dbReference type="OrthoDB" id="6082470at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="223" mass="25501" checksum="CEAB1C602E0F032A" modified="2023-09-13" version="1">MKPVLLDSIQFKFKDKDKEVIKSYKEIFENCSNLIIEKGEISNDLADALIIPGNSFGFLEDLQERIQDVIIKEFEGEIIVGDSFIIPSNNEKIPLLIFSPIFRVPTDVHISTNFFSSFRSILLTIKKYNSNCGEKEKQIKNVISPVFDINNSKLKPINAAKQILEAFRVISGFSKSKSKSKSKSKSEKNIIHEIHFPPGLSEPFNQEVHLVDEKKKLPQNHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUE7</accession>
    <name>A0A9Q0LUE7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUE7"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="249"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="479"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="70741" checksum="FBAC24873D581E7D" modified="2023-09-13" version="1">MNEILFFPHKTAHAGIIIGIEKTTKPIQFKFENENENENEKQIKQISSSYFSTIFLFKNGKAIEYLQYSNNPSKIQIEENIQKVTVGNRNEAILTKEGNVFAKGDYINSRNKNEFINISSLIEDKNDRIIQDVVCGRYSIYLLTSNQNAYGIGDNEYGQLGFDSNIFKERRKPILMMKNVSKIFSGNDSIHVFLLNSNQELFGCGWNYFGQIGLKETTTEGILNKLTKIQNIPKGEIIDIKTGYWHSVIKLYSCGNSLYNGLGKNENENENENENENENTYEFTEIKSSLFENDYIIDFSCGSTHTLILTSNSKMIAFGWNLRSELGTGDREDQSIPIQIELPKLRFNENISNYHIHCGYYKSFLYYSPHSFSNLEEDLIKLFGRKEFCNISFKTENGEIIKAHKLILKYRLNQNQNEKLQEIISKKSFKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQGIINEIKIGIDYFQLNQTNPNLIDLLINKFNNQNQNNKKEKIQIEKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUS3</accession>
    <name>A0A9Q0LUS3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUS3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="68901" checksum="7B1355DE7317B403" modified="2023-09-13" version="1">MNEILFFGDNEDPILIKNESNIILKPIQFKFENENENENEKQIKQISTGICSIIFLFENGKAIEYLRENDSKQNPEKIQIENIQKVIVGWQNETILTIEGNVFAKGNNINPKNPNQFINISSLIEDTNDRIIQDIASGAHSIYLLTSNQNAYGIGSNHFGQLGFDSETLPKTEKPILIMKNVSKIFSGNSSEHVFLLNSNQELFGCGNNESGQLGLGESRQKETKIQKLTKIQNIPKGKIIDIRSGGIHSIMLIENENENQNPKRKLYSCGYYECNGLGKNENTYEFTEIKSSLFENDDNILDFSVGFNHNLILTSNSKLIGFGDNLYAQLGTGDTKNQLIPIQIELPKLRFNENISNYHVSCGLWKSFFYYSSPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVRDYSELSNKSFQILEYWIYSNQIKDEIQITQEIIDELQTGIDYFQLNQTNPNLFDLLIKKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUY7</accession>
    <name>A0A9Q0LUY7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_05608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUY7"/>
    <dbReference type="OMA" id="RHLFHYG"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5077918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="233" mass="25998" checksum="A08FF8B9248F35A9" modified="2023-09-13" version="1">MSFLTQKVAQEIDDLLMNKMGYSVYSLMELAGLSCANAVYRILSEKKIEKGRVLVVSGPGNCGGDGLVAARHLHHFGCLVEVVYPKRPNKELFQNLIKQITGLEISLLDTMPEVGKVDSDYDYILDGIFGFSFNSKEGKIRSPFDKILDTLSKTSTPVASIDIPSGWDVEEGDILKTNLQPETLISLTAPKLCAKNFKGKYHFLGGRFLPESLCKKYEINLPKYKDTEQIIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVU5</accession>
    <name>A0A9Q0LVU5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVU5"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF7">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="107712" checksum="ADBD46948EA6A25A" modified="2023-09-13" version="1">MKAITCYICGKKKIPKAQVPSKNELFLKLESTPRRKSNKICNRCYRDNLKMKKFIQENKDIKEENSCLKQELDYLKELVQQQKKEINHQFSIYKEVKKQLKTTLSWVNILNEKCDSIARTEMELRENLCEVQKEKENLKNQQITIHSHLMYQLTKENQDLKTQVEKNQIKIGNLRDSVYYWKITKPKRKEKKKEEEQMKRDSLKNLSQNQTSLDGENENNQNENNQNEMGKGKEKTKIESKSIKKFRKLYENDRRMRSAFNIGTKIVGISISKFYRFLNLFEIKTQDGLQDYCDEVKIKLAPIVNSMAESILDLSAEEVEQSTDPSSTQTMEHMKNHFISDKDIDKIANSSRKLFINKELTNSSSLLDLKEKIYQLVISNEKKNSIERKDQNKNNSNQQIENESQPEIDSTKKIDSIFSHDVAYSHRNNRAADACAIFIEANTKFNRIIHYQRMSSTSTIHPQSLEGFLIPKGIQKLSEKYNILATVHDQNTSSKVKQCFPNIMHLLDPWHVTRSIRRRYNKLVNKFCGSNKKKRSKEESEKMRKKKEHLMSWKESIIFHFLRCAKSCQGDMTTLLSEWFRYFLHAKGDHSLCPKNSPCTKNENSNENKHPEDKKITNKEEEAFFKMILSDFTIIKKLIFCRYFLSTSYNESFFSTLNGYREKISHFKNYNLLYQLAIIDWNQNREKENEKEINLGNQENEIEFNEKNALQENQKKEKDMEWQKELLHLSLPGIFQKSTSYLKNLTLSRIKKKKRNSSEEIVPPQKEKKRSRKSPKKEASLKTKKNLISTFLLSKIQPNLFDFENYSLLPTFQIHFKDALEMLNPKETHKQTQKETENSCPNIHDLHIFSNQNPSLLSRKSKIDNKNDVPIQTKTNNHNAIQNIQLPKPREIQLLEEDYIHNKREEIKEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWE4</accession>
    <name>A0A9Q0LWE4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000037">
        <property type="protein sequence ID" value="KAJ5079110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWE4"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="276"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="331"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="502"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="626" mass="73074" checksum="AE4E2DB5EC61A0F6" modified="2023-09-13" version="1">MNDCLFFGWNQNPTLIKNEPYKIIKPTQFKFENENENENENENENENENENEKQIKQISSGYFSTIFLFENRKAIEYLSNSNQNPSKIQIEENIQKVSVGCRNEAILTIEGNVFAKGENINPKKPNKFINIPSLIKDKNDRIIQDIVSGLSSIYLLTSNQNSYGIGSNHFGQLGFDFKTLKKTEKPILMMKNVSKIFSGTDSNHVFLLNSNQELFGCGNNQYAQLGLGESRKEEKRIDKVTKIQNIPKGKIIDIQCGFSYSIMLIENEDENQNPKRKLYSCGNYQYNGLGINDQNTYEFTEIKSSLFENENDYILEICVGADHTLILTSNGKLITFGGNWSGQLGIGDINYQKIPIQIELPKLRFNENVSNYHISCGENSSFLYYSLPSFSNLEEDLIKLFGRKEFCNISFKTKNEEIIEAHKLILKYRLNQNQNENEIEKLKEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQLFEYWIYSNQIKNDIQITQEIIDEIKRGIDYFQLNQTNPNLFDLLINKFNNQNQEENQEKKKKEKKENCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXT7</accession>
    <name>A0A9Q0LXT7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of g protein signaling</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXT7"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="199"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="432" mass="51230" checksum="9ADB41187068357A" modified="2023-09-13" version="1">MSILQESKFIDIQSTFLRLANVVSNMACNFDNLLYSIQSLFKYLTHLLRNYSMFFDPQGTLNSSIKKIQNILLKMLEEWSQFFIECDSKHIQKVHSLYLICRKIQDQLKEREIMLEKLENENIQNEQFQQFENNLLKDMEIIIEKRHDFLSETFIQFSNGFLNFFKQYSEKTKEILLLVQDKSHTEIVDMEDPITEASSIEFIFRNKYGRKFLGNFLKKEFCFENLDFFIEVENYKKIEDPIEMHKKAQEIYNKFVKENSESEINIEYGIRNQIKNQLPNADSTIFDQAKQIVIRLIKTNSLSRFLESEDFEKLIQRLQPKQFLFTEKSNIPMTSISDPTTTQSQIETDSEISIDESLNDDASDSDESFHAPFSFLPAMKKSILRSKSELFHPEQKESETFFGHRFTRSNSLLLFQQQKSFSKPFFSQINEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYN7</accession>
    <name>A0A9Q0LYN7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adiponectin receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYN7"/>
    <dbReference type="OMA" id="EPWQQDN"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5079700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="302" mass="36096" checksum="D566B2603CC37104" modified="2023-09-13" version="1">MNLRLKNNTNNKNNKNNNKNENENENEKTKKQDLITFKEIPYWLQDNKYIEKGYRVNWNKTECLKSLTFIHNETWNIYIHFFGFILFIIILIKLVLSETFQKSTRTEKFFFVYYIFSVESCLGSSTVFHTFYCMSKNIKKKLLFIDLCGVIIIGSGSHIGPLFFIYRSFPFLQKLYLSLLALSTSFYFVMSSTDTFQGYEKRWQRFGYYLIYALLGSVPVFHGLFIFPKERYLPVFFSFFLMYLSYLIGILLYQLRLPERFFAGKLDYFGQSHHFWHSLVIIASLFQFHTLLCGYSSEFCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZA1</accession>
    <name>A0A9Q0LZA1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000012">
        <property type="protein sequence ID" value="KAJ5080153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZA1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="204" mass="23411" checksum="FC55686918C732FC" modified="2023-09-13" version="1">MKEWINLLNFSLEVENNLVEKEKQKILEEKKQKNDEIITYVNENESFYENQDYYELVADDGSDYDGEVILVEQIGSDDEIGSDDEILEIIETTDDENLIESDEDKLNQKLIQKLNEKLNEKLNEKSNQKSNQKSNQKSNQKSNQKSNQKSNDSNSDVIEIVDDDGSDYDGEVILVEQIGSDDEIGSGDEILEIVETTDDDEKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4A2</accession>
    <name>A0A9Q0R4A2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4A2"/>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057855">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23389">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="WDR19 first beta-propeller" evidence="4">
        <location>
            <begin position="451"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="599" mass="66323" checksum="86FF9440C80CE050" modified="2023-09-13" version="1">MSLQHIYSAAPVTTRAKVTHLGGDPKGKNFLFCNGRSVFICDIENPLICDQYTEHQNETTVAKYSNSGYYIASGDSIGNVRIWDTVNKEHVLKIEFRALSGPIYDIDWSPDSKSIVIVGDGKEKFGVVVHYDSASSVGEISAHSKAITSCAWKPNRPYKIVTASEDLSVNFFTGPPFKFSHSLKDYTRFINCVRYSPTGELFLAVSSDKSGIFYDGKLGQKKHTLSQEDGHKSSIMSCSWNSDGTRVITSSTDKTVKLWDVETGKSISTFTFSDNPTFDHQQLGTLWQGNYLLSLSLAGTISYLDINNPSKPIRQIQGHNKSIKHISYSKQENTIFSGDYNGNIYAWEVGKGSINGFTNTGHTNQITSMDIIGDQLISVGFDDTLRKASINDRMYKESVALEAQPTDMAVSPKNPDISIVCTQGGINVYKNTNLVSETKVSYKPTAVSIREDGNEVAIGGADKKVHVFDFNGNDLKQKYELTRHNGQITVVRYSPDGTLLASGDTNREIIVWKNKEAHNTGWVFHTSRINTLNWAQDSIHLASGSVDGQIIIWNSDEPKKRVIIRNAHQSGVNSVAWIGENVLASTGEDCTLKTWNIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5F1</accession>
    <name>A0A9Q0R5F1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5F1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040458496" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="468"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="695" mass="77019" checksum="605FEF4750540B87" modified="2023-09-13" version="1">MNKTSFFLILLIILTTQIGKVSTKLFETIPGNFTQLDILTEPSTQDYGRSSSVFNDVIIVGDSFTMQVFIYRCNGSTFILEQTLSEPSAKFGFSSSISGNVIVVGSNESQEVFVYRYNGSYWNLEENFSGSIGYGFSVSVDEDVIVVGACGSKQAFIYRYNGSNWNLEENLSQNLDGYGNAVAVSGDVSVISANLSKQAFIYRYNGSNWFIEQNFTGGSYGYLGTDVATSGDVVLISDIWNDIVWAYRYSEGNWTLEQTIIYTGVGGSGLENQNQNQNQNQNQNQNQNQIPTLSGEFDFGSSLSISGDFIAVGADATCIFFYQYYSDQWNKTFGYKIIQTNEHVTAGISGIIGVWGVTFSNQAFVYAMVPPTINLINCSSLYSSFECYWNETDYPFPLYYQIDYGVGWQIMEEPIILEGNISYQIFNSFYPNITGNANYSIIIQACEPVSKLCGTQSSQIDLTTRIPVVQNLTFVSTNESINVTWNPPNVTMDGEIPDLDHYLITYYQENELSITNITVDNTTTSFEMTSLDCGTTYYFAIYACRTLACLGDDMGALFSTTIDTMFGPVYLLQCSSHPLSISCSWLIPVNCANNPFFYSFSFQSSSGIDSGSFLVNGTSTSFNTQYDDEDYFIQVSACDDYFSCGESSLSSAQPGTLTSSNSTSKSIITISVLFLVLGFIFLVGAFCIVNKHLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5H1</accession>
    <name>A0A9Q0R5H1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5067989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5H1"/>
    <dbReference type="OMA" id="VNEGHND"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="638"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="671"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="704"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="739"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="772"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="808"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="841"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="876"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1069" mass="122916" checksum="19D57694C11D072D" modified="2023-09-13" version="1">MNENYNLLEIIEKNQIELLKKIENIEEKKFKKETHKTILNFALEKKASKEMIELLISKGAKLKRIDEKERNSLHHAIMNNSEIEVIELLLSKGISINSKDKKEKTLFHYSIIYYKTENLIKMIEYLISKGINIHAKTTTNKTGLHYACQKRSLEIIKYLISKGIDINVKTIKGDTILHYACLSNSVDVIEYLISKGFDINAKTEFNETTLHYACLENSVEVIDYLISKGVDINSKANYDDTLLHYAYQKNTLEVIKYLIEKGLDVNAETKYNETALHFACEKNSLEVIKYLIEKGLDVNAKTEWTQVPFHYACEKNSIEVIEYLISKGANIHAKTDWGQTSLHFACKKNSLEVIKYLISKGLDINDKIDSNETSLLFACEKNSLEVIKYLIEKGLDVKAKTDSNETALHLACLKNSVEVVKYLISKGIYINSKTNKNQTILQYASKKNTLQVIKHLVKKGVNINAKTSNNETALHFASQTNSYKVFKYLISQEADIYIKTKSNETMLHRACENYSLKLMKYLIEKGIDINSETNQNETPLIYACKYNTKVEVVRYLIENGAKMDSRTKYEKETILHSAFFQSVSFEVINYLIEKGFDLDAKTNRKETVLHYACKYNSSLDIIRYLIEKGVDINAKSDFNKTPFHYASSTNSIEIIKYLAENGADIHTKTNYNETALHLACQNNSFEVIKYLVEKGVDINAKTNHNKTVLYYACERTSTSIEIINYLIEKGVDMNAQTDENQTALHLVCKYYSFEAIKYLIEKGADINAKTYNDETILHLACQSFFGSLESIQYVIEKGMDVNAKTKYDDETPLHFASKYLSVEIIKYLIEKGADINAKTNEDKTVLHYACSSFTSQFEVIKFLVENGIDINAKTTDGDTALHLICESFYDEIEGTKYLISKGADINAKNNNNETPLQLSIENDKKVITIILLMNEANFFDLEENEMLNEIRELITKIYSVNEDMNNLLQSNQLSDLTIKSNDSFQFQVHKLILLTRFDNNESILQKFINNCYQKPKKEVEIALNFLYTGFADFDEIQQNFINLKHKEEQNSETNNNKEDEENLHKKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5J4</accession>
    <name>A0A9Q0R5J4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Circularly permutated ras protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5J4"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003556">
        <property type="entry name" value="NRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="130" mass="14770" checksum="5FC49120C2D8F889" modified="2023-09-13" version="1">MRDSYMRSGEGFLIVFAINSRNSFDEVSVFKEQICRVKDSDHVPMIIVGNKSDLENERQVSSGEGQDLAKTFGCPYIETSAKTRINVEEAFFGLVREIRKVKFGKTDEKTTGKTTKTKKKRKLFGKCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5K5</accession>
    <name>A0A9Q0R5K5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with ribosomal protein S21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5K5"/>
    <dbReference type="OMA" id="WEGDAEW"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000017">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="329" mass="38098" checksum="17B6EC3911B27C60" modified="2023-09-13" version="1">MTDTVVETPKQTEETLEKKPEITKPKKTKKEKKQKKQKVTQRTALTYISQEQRKEDLKMMLACSVHLGTHNLENMMIPYIFKQRKDGLNLINLAVTWEKLHLAARIIAGVKNPQNVCVISARPYGQRAVLKFAKYTGTHAIAGRFTPGTFTNYIQKKYIEPTLLIATDPRIDHQAIVESSYVNIPTIAFCDSDSPLRFVDIAIPSNNKGKLSIGLLYWMLAREVLRLRGEISRKQQWNVSVDLFIYRDPDEIEQQQQKEKENEKEREREEKAKQQREEEKKKQEAEDQAQDESDNEVADQDNADQTKPDDKSDSDSDWDNEDSKKDGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6P2</accession>
    <name>A0A9Q0R6P2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Intein-containing fanconi anemia group m protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_12756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000123">
        <property type="protein sequence ID" value="KAJ5067949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="735"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1592"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1865"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5067949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2165" mass="252329" checksum="0320FE8F2B8CE81A" modified="2023-09-13" version="1">MSNFNNPKNLGFRVAKDILEEQKNKSNSFPKNPKPLNLKDLQKKKPHLQKVFRPNEFFQKRSEKSKSKFSKESKLNLDSNTNTNSNSNINSNLDLDLDTNTNTNLNSNSNSITNLDLNTNTNTNLNSITNLNTNLDLKFNTFSILNTNTNLDSNSNSNTNLDLKFNTFSILNSNTNTNLNTNLELNTNSNSNLDLNSNSNSNSNSNSNSNTNSNTNSNSNLDLNSNSNSNSNLELNSNLDLNTNSNSNTNSNSNSNSNSNLDLNTNTNTNLNSNTNTNLELNTNSNTNLDLNTNLFLQNFQFPSNNFSNPKNLEIQKKEDHQISKKPINSKFVEISINSFANQNPQNQFQNNQNQTQNQFKNQNQFKNQTQNQFQNQTQNQNQNNQNQNQNQNQNQNQFQNQNQNQNQNQFQTQNQNIQFQIYPNLHSNQLENQHLNQNQFQNNQFQNNQFQKEKEKEKENDINQNYPNENQNQDDEEPNFFKLSENKHFLENKPFESSQIYSNKSNPKTDEEIQEEQNNPKLDQWLSKNPTNQNHFKSRKTEMEIEKQSENENTPIRQTESKSPQSNSSGKRRSNRTNPDSNQLENQNQLENQNQNQNQNQNQNQNQNQLENQNQNNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQNNQNQFQKNQFQNNQNRNPKIFTNLFENDVDENEFENENQNNHNYNHNEKNYEKQNISTTHEICFKKLEKWIYPINKSKRMYQYNISKTALFYNTLVVLPTGLGKTLIAAVVMYNYYRWFPNGKIIFMAPTKALVTQQKKAIYQTVGIPMEITVEMTGDTSPQQREILWKTKRVFFGTPQSFQNDLKKENCPIDSIVCLIVDEAHHSVGKYAYNIVFSLIQQKNKNFRVVALSATPGSNVQKIQTIIDNLAICKIESRSADNGDVSPYVHEKKFIREIVSLQNHNEIVIISKLFTPIVENFLNLLFTSNVLPKKHINQLSILTFKMFSQKLQMTKMDLNQKRVPDLRVGQLIARFGFCMSLLHAWKLLHFYGLKTFSQFIHSHFIDPEKKKKTSSLLLKQENFKKIQEIIPDLIQQAKSSHPKIDLLMNLIAQHFEEQKKQGIDSFNQTRAIVFSTFRDSVEEIAENLRKIDLVKVAVFIGQNTSKNKKGYNSKQQKSTISQFRQGNFNTLVSTSVHPDEFIILMNPKSEIMIQKIGHFVEFFLHKQKGFAKKNISNQHWKCLSCDKYGENVGFYPITHVHRHVRQNRVLEVSLTNGFSALVTEDHSLFTCSQTKSHKIKLQKTKPQINQMINFCSSFSISSSSSSYCKIHRIDLIEQFFNNSSQNNLKTPKYFQKAIHNSKFIIVYSSTICSHEFSFDLKLQLHIIQALQNKNFYVLEQYPQDQINQIQQGLKLFTKSSFFDKNLFHFEKEDLEKYYLDCYRKSIIWIENHSIFNPQTKHFESNLENAATFPEEMIFFFKQRIYLNNMKYQDYLPRFIKLDHFFLNLLAFYLFSSTQKLPNSTFSYQRINDDFNSINSYFQKNEIILSHLFSTFLYCGTVNSKKRIPNLIFNLCFGDQLYFLEKCKHFTKIQYQTTKYDFIVESRELMMGIIFLSKQIYKENIINLSRISEEKIYSQNTNQNISCSKSSFYCCSLETKESSKKETFFSNLETICEVDSQPEFVYDISVQKTQKFFGGLGLVNLHNSVGEEGLDIGEVDLIICYDSSVDVTRMSQRFGRTARKKAGKVVVFITESFEEESFEKILKKETDILQRLSRTKFRLSKNIPELFPNQTNPKCVEKKLEIIPYFEGNEETEVRSKIPTKVELELCERSVQLPKQRWNYSLEKYIPDQNLTFSSHIGNSTQTKLLVDVLIYLDQFPRKIPLEILSKPLSSSLSPMKVNEKNEETDVSFKLGTPKSKNMKQSPLRKTKSNSKSKLNSKLTFTPVDSQENIQKSNKKIESKWEVSKINPMENSDTTLDLNPDIDINTNLTTNLTTNLDSDLNQKNSSYFGKSFKDHDLKLQMLLKQKGITTNINGEYLIKSLKLLGDPSTRKDIVDLCIHLYPEIWDCYQKSFPKKLSRIKFEKLIIPENFSKYGVYQNPRSFEFSLKDLNQENGNNFNQENGNNFNQENENILNQENGNILNQENENIFNQEKENNFNQENGNNFNQENENILNQENGNILNQENGNIFKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R758</accession>
    <name>A0A9Q0R758_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R758"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="80" mass="9681" checksum="1A1EAC0EECE29FFE" modified="2023-09-13" version="1">MRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIIEELERGIDYFQLNQTNPNQKKTEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7F8</accession>
    <name>A0A9Q0R7F8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7F8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="199"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="409" mass="48688" checksum="77198E78E14858F9" modified="2023-09-13" version="1">MESILSYIYYGNTSFENQEDLLQLLEISIYFKLNLLKEIIQEKISNSINYSNFFQLFFQNRNLKSNEIEIKCFEFLNQNFSQIQKDENLFSLTKEEIIRFIQFKQEKKEIFELDFFQFLSEWMKKSNKKLRGKKYRHKMNVKKRLSHSFFSLFDKDSISKKVFNKLKESDFILPKSFLLQKMKQKTKFYKNFPQFSDSEIEDIRYAKKLKKWINDNEFFSKMKKGYSAKKDGFNCQNWHKAVDNKGKTLVIIKTTDNYIFGGFTQIGFTTDKSKWSKILQKENFDYITDQNAFIFSLRNDKGNRKPEKFSIKKNDTKYAIYYDYFNHGPAFGGNAGSGDFILDSNLQSGCSKFGNSYKLPNKANFQSKDQSNSYLAGSYDKWVVDELETFYLKFSKLIFFFSIISIYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7N2</accession>
    <name>A0A9Q0R7N2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_02078</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7N2"/>
    <dbReference type="OMA" id="EYEIADC"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000060">
        <property type="entry name" value="Serine/threonine-protein kinase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0278509-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="647"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="570"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5069508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="906" mass="104280" checksum="B0A5AFA7E0CEE78E" modified="2023-09-13" version="1">MADNQQNRQQRNKKKRFVQDKISQCKKDKESTLELSNMGIKILPSSIGSLSELTCLYLNDNYLSSLPKEMKKLGNLTTLNLNNNSLSSLPDLIGGIKKLTNLAVCNNQLQSLTPKIGRIITLNELFLTDNKLQSVPDEIGSLVHLSKLDLGGNQLSELPQSFGNLKSLKELGLSFNLLKSLPEDISELQQLEQLYLNDNSLTNLPENFGNLLSLRELELSNNSFKSLPIQICKLSSLSFLYMNNNQLTEIPNEIGNLKSLTVLWFDSNKIQTLPKSIGQLKNIKSLKLSDNQLVSIPSEIGECSSLIEVHLFNNKIKEIPNSVGKLQLLVKLILTENQLENLPSELGKLKNLTQLHLGGNKIKQIPDEQGKFHEMKDFGISPDSFISLPHALPKFGSLITSNSKQDQKIVTQFQNTHKEDLISSLPKRKNSKSVVWIFPSTQEFEDEKNQDKTNSKNQNQNQNQNQNQNQENQNNEIYDSKITSAFLNDLLMSNMLGYSNTKSSLSFSRFDEKDYEPEFPDSIEEMEKQNNENNENIQNNENNQNIQNIQNNLQLHSFSNFNIKQSHMEMNQFQMKLYEAVNLINKLEKEKITLFQEKENSDSKRKKLEILLKKAEEKLRKFEMRSQSMDEQLNLMENYNEIENSEIEFKEEVGRGTFGKVFRAIWRGKEVAVKLIFPEYNTGMYLTEFQREVFMLSKTRHPNIVLFMGACTKPPNIFIVTEFMSEGSLYHVIKKDNFKGSQEMWLKIARDIALGVNYLHLAKPKMIIHRDLKSLNVLLDENYNSKIADFGMSRIKEESAKLTKLKGSPCWMAPEIFRNEVYNEKADIYSYGIVLWELITKEFPYKGIDNPIQLGFKVAYQKLRPDISKITDPKWKDLITQCWADEPDDRPSFDKILEILNTFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7T3</accession>
    <name>A0A9Q0R7T3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7T3"/>
    <dbReference type="OMA" id="HMEVRCR"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="348"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1107" mass="129976" checksum="1DC02655F7B8687A" modified="2023-09-13" version="1">MNQPDNIKQELIEILRTTDSEYKEKEGEFNPLGRAVAIFRDKADPNAELQEIENHLVGVEALMKRITEVYYDGFNKSIQSFSEVLKNMNAVQSEVETLYNQITTCKTMMNLSISEIKTAWEFSLQYKYMLKLIDQIIVLQKVPEILENYLQNKNFLHASYLLMSSFFQLVSEDLIQISGLTGILEYVNDKMNIIYQQFIEELQGYIYLKKLPNLKDESDEDSEEETQDIDLENGIIPQNNQKEKNIEYESEKSFDKTEDINSNSNNNDNSNSNINIQRNIKKEHYQLKKQKPFDENSVENLLSGEEIDGTEQINSILSNEIEIESESKKEEEDIRKKNLIYEDINNPQENNTAYRMKLLVESLNVLDRIGTTAQLIRANIKPEILGLFEDCIYEIKNTHYKGDFPIQKLFQKQIPFFHKKANSLIENENSWGILYTLVKQMAKKTLKVIRNHKIVWEELHKKNFRPDRRVIFAQDNTKLLGEYEIDNLPNKIYGLSPEQEKNSEEPAYEYTMEIVWNTILTEIQDFIKPYIFPSGKSSFQKNPQLKKKNDNTIQFSFANSESFVNDYNGKFEQLYQQLTAEKRSKRRNIKQKLLPELDIKSSMYNVISVYQLLVNFSDQVNRSLKITEKSRIQIFLDEFLNNLLFPQLNFDFMEKLNNILNSLDAFKPREKNIHAIYSSEESNRPLLQSSIDIIQLVSQLFTSGILMPSYMENFLEVINQLLKTYFQVCQDQYDKVISGSESHNYFKNQDAFKIQKDDPIFISIHSKFSEEIEKDQNIQQNQARLSIQLTDSERRSSGSIEMIMKELEDKIEKFSQKEDLFEQKFLNNRKLEKNGLILESPRLILLANLSDSLDWVASCVKGFIQSSSQIDSLSHQTNPNHDKKYSKSREKILFNFHYHPKIFDSLNLLVSHFRKLSARCLLTLKKEYRFHCYYFLQQISNVNYALDQEPTEPDMFINELNKDLAFNEDIMTSFLPSNQKSYLFSGLARLISKTLVEGAREIKKINKNGIMRMVRNVFAIQQNLTNIVSSQEKHFEKVRHYYDLFNSRTPDNLIAFDIEHPNAFKPEEYLVINKVLFWNYPKNPAEIHFSKSKIPNNLSMQVTFDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7Y1</accession>
    <name>A0A9Q0R7Y1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sec31-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7Y1"/>
    <dbReference type="OMA" id="SNIAPMP"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="854"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="971"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="971"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5069793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1128" mass="129243" checksum="F1AACD43C40C5553" modified="2023-09-13" version="1">MALFSIQQKSICSWIPFVPNKLEIKNEEQAKQLQSEDLIVTAPIETTNENDFSLKIFSPTFYSENEEKKPILLGTHHIDSYVEKIIWGKSIIQDSFPLGVLAAGMNDGSINLWNPNSIIQSDSENVLISHVSHHSQKVLDLDFNFNRPNLLATGSSKNELYIWDLSNTESPKIYSPISKPTPELEMTSIRWNPHNSFQHFLGSTTSNGIVSVWNLANKQEIAKYTDKRKRKFSSLVWDPEIPINFVTSVDDEDQPCTYLWDLRNKKTPVKQFLGHKRGVVLASWCPFDSQLLLTAGRDNKIIIWNTITGKQVNEITTESGYPTHIEWSKITPSLFLSCESEGKINIHSAQEPANETNPSISEIVPKWMKKPASISFGFKGQIISTKTLKSQKESQVSIHQPISTENLMQRVSKLKNAISGEINELEDYCQEKIQNEPDSKEFWQLVQIVSSQDERKKLQDFLGIKENQLKENLEKFQDENDKKDEDKNENENENENENQIENENENENESENENQNEKVEETPKDDFSQLFNSETTPDFADPNLESFSQYQIQDLQMDLQGFDMGFGETTMENKKDEELMNEDQLDEMEQLNFEQDLVLEIDSKNAFNDIITQALLLGKYELAVDCCFKNNKIPEAFVLAFAGGEELWKKTRNRWIKDTKFPFAGLIHALSENKLEAIIKRVAIQNWKEALSLLSTYAHQDDFPHLCDLLAHRIENEYKNINAAIVCYICSGNLERVVHLWKQEFKLVNQESILDLIEKFFVLRKAISQEILPSNILVYLKNFFVFLSSEGLTSLVSQFLDMIFASKNALDSLSKKDYQNFLDLKKVIDGAVIVPSQSRVLQSKTMHGLFDSHESANIPKRNKGPSFPPNLQRNPQNKNMGNFGLQPPLPFDQRGKTDPTPIQPTILNPVQNPILTPNPILTPNPILNPNPILTQNPILNPIQNPIQNPIQNPIQNPILNQNQIHVFDPSQKTISSPQQTQTHLTSSPPKKIQTQQAQPQKPKETKQQKIQPQNQTKQNKDLPLKYKPFVDDLNHFLQEILSNPKAARFVSQAKKAQEKLIPFYNDLYDEKISDSTLQKLTGLINLTKNKNQSEYQKLVLDISKNDWEEVKNGFVTIKWITKTIISLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R842</accession>
    <name>A0A9Q0R842_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R842"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="143" mass="17371" checksum="75EAB185E930FAC9" modified="2023-09-13" version="1">MIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLIKQFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8C0</accession>
    <name>A0A9Q0R8C0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_02124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8C0"/>
    <dbReference type="OMA" id="PDETKWP"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000375">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5069554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="303" mass="34734" checksum="E7BFE2BFAA26359F" modified="2023-09-13" version="1">MSHHTLDQIVKEHKVGAGTYGVVYKAKNIQTKEIIALKKIPLERDDEGVPSTAIREVSLLKELSHPNIVSLLNVICTSEKLYLIFEFVDYDLKRLMNKQKGFNPSQTKSLTYQLLQGLSECHLHSIIHRDLKPQNLLISKTGILKIADFGLARSFSYPLRTYTHDVVTLWYRAPEILLGSKHYSPAVDMWSVGTIFAEMLLNESLFPGDSEIDQLYKIFQTFGLPDNNIWPGVTELPEFSTVFPGFSQHMLKETIENMSENRFIDPLAIDLLEKILVLDPNKRLTAKQALKHEYFKEFNLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8T7</accession>
    <name>A0A9Q0R8T7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8T7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="404"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="579" mass="69352" checksum="FC46612BEF56E4D5" modified="2023-09-13" version="1">MDNNNNNNNNQIENANQNENQIENEMKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLMEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLNSNEIEIKCFELINKNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNQRLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDLISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIENKEKEIEDKEKENQQMKIEIENKEKEIEEKWKKEVEDKNKEIEDKWKKEVEDKNKEIEEKWKKEIEDKNKEIEDKNKEIEDKWKKEVEELKSKFELMELQKIFSDSEIVKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKQNFIFGGFTQVGFKHSSGEYINDSNAFIFSLRNDKGDRIPTKFTYKQNYAIFSSLSFGPNFGGGHDFYLYSNLQPGRSDFGYSYNLPNGITYESNEAKSYLAGSYDKWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9K4</accession>
    <name>A0A9Q0R9K4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9K4"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="493"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="598" mass="69958" checksum="51D45803974F2496" modified="2023-09-13" version="1">MNEIIFFLRNQFPNLFKNKPNEITKPIQFKFENENENENENENEKQIKQISIGYYSTIFLFKNGKAIEYLDENDLNQKPEKIQIENIQKVSVGVRNEAILTIEGNVFVKGEDINLNNPNEFINISSLIEDINDRVIKDIVSGAKTIYLLTSNQNAYGIGSNQYCQLGFDFKTLQKTKKPILMMKNVSKIFSGNSSNFVFLLNSNQELFGSGYNFYGQLGLGESIKKETYIKKLTKIQNIPKGKIIDIKCGYFHSIMLIEDENQNPKRKLYSCGIYEYNGLGQNGRIDEFTEIKSSLFDDDNILEISVGHAHNLILTSTGKLIGFGWNHYGQLGTGNTNDQLIPIQIELPELRFNENIYNYHISCGDFNSFLYYSPLSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEAHKLILKYRLKDENQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIETGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9L2</accession>
    <name>A0A9Q0R9L2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator 2/tumor suppressor candidate 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9L2"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="614" mass="72871" checksum="F8AE6C5FEE549D86" modified="2023-09-13" version="1">MIESILFCEFDNKQGPKISFQFPENKILTSKFSKIAKYIVTKPEYSGNVITISVDQFRVMGCSTVVQSGKYERNMYIFNICFVFSREINYEKIIPYEKVIEKLSRIMKLNEEQNQALSNIKKRDEIQQILIEIYQELNQKKEFQFDGIFSNRKKPTDTTPTNPLQNEMSLKNKRVNDLHENLPLGIYLKTIPKFGKYRYQIRDDHVPIFIQQIESYPIGEWDLAVQKVLSKIDGKKYIKLIAYETEIELEIVKICISRLLYLDIIRLVNVFQYANTYISTPNIFQLLHNKELQKKCLKTVLLHPISEISSYFSNKIDENQNLLQIYFQQKYSHQHKEQIKNIESIQQNLEAQRNKELTNDSSIIPDESANKIEKGRTDEGEMGKTDKNEPKNTSDPNLNEEKEKEMKEENFQMIIENSPFDQQDQIFENTKENEIKMKLIKKRIKYQFLHKIFTLYCRLSLKSNYANFCRQYSPHKFGIDEVSLITFGELNYLISKVQSFPILEIHKQPLLQFKNQLEQLKFIHEFQKFRQNQNNEQTQNQEIHLQKGQKWLQDVHHEQKHHAFLLSLILKTFDGKHSFDQICCDFGIDITKLLQMIKISGRKIYIIKCPEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9U6</accession>
    <name>A0A9Q0R9U6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tnf receptor associated factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9U6"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="166"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="166"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="563" mass="64519" checksum="F14955D9D727DC89" modified="2023-09-13" version="1">MQKNENLEINEYFEYVDPIDKISPSLICKICMLPFVDPVVSDCKHTFCAKCFESAKKSNQKCPVCGEELKITENNTLHEVFKNMVDGLLIKCPNHIKSCEHICARNEIKEHLKQCPFQEVTCENEGCEEKILRKDQEKHNEICAFKLVDCPQKCGAKLQLSQVEEHLKTECKRTPIQCELCKEWVPKEEIEDHMENECRQKIIKCPHYASGCNTELKRQEMMNHLQNDCPYEKIKGLSQLHNQLIDEVLFQQKQIDALVLQIEQFKELCFFRDMEAKNNENTSQNENTITQSGARTPVFGRLNRDKANETPKNLQLTSLSKELLLRILHLLEKKHLILFAMTSKFSTEISFHPSLWKNIDLSNQPFTTCEQFFAVLKQHPKVEALDLSSVLRKLEDKGQVINYVTRLQNLKKLNLSNNYLSAADTQILADSLKDSRNLTSLDLSWNFMSSSNKTIAQAVENNTSLKYLNMTQNYVRDDTALEFARILDNNSSLITLNLSANLIRKKGGEALVKAFQKSQSLCELNISSNKVGAGIENQILEIQKSKSKSKSKSISKSNSKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA80</accession>
    <name>A0A9Q0RA80_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA80"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="706" mass="82640" checksum="E525E7D45F0EFF80" modified="2023-09-13" version="1">MIDIFNKIQINFIKESSNFEVKVLIQNKHYPAQLNLLHDSFTIQTLINSENIEFRNSIFSTKISTSVQNDTLLRLQINPDSCILLITKNSTESEIISRTFKMLQIYNHDLFESGFIDFNPSGKILTLNDELDAILWKSYKRGNIMFKFLCSIENQGFILSTIQITENFTTIQMKNFRKITLKWNQNPICRIDSKSPKNIKIKSRHHSIIVDCKNPYSAYFLFKSFYYYKGIKQNQLLITFKKDSVTRVPENPKIGKKHFRKLKKLRDSSDDSSLRSSIHGSMKEINLAALETIIPFDNKDDLYKEETAKKTEKNQEIKSIEIQEIKQIKNDEVQEIEIEEIEQMNEIKIENLEQIDDSTQKISTPQDIPLVSENFTIPQVKELSNSFEVKEIPQSFEIEKIEDNSNQEILDIQQDKDSFNVELLNITDDSTKSANFIFGKEKLKLQNEETNQDFILDSNCLLFRKSSKRNILILKLNDSKILAKFKRVKDLENFITKFTKTQNKISKMDKTKFMVIISKSGKFKEDSEEGILSFTTKGIGLIIEEEKLFFDYNPKFEVSFHPRNPLLIKMKFTNEQNYILSFNSLQDIQRFRNTFFKYFNKYGKEYIFQVQPSSENLLGETSILKLKPNGILSLDHPTLGFQDLKITSDYPILKTNKIDPHLCAIVTQNKSVTLNFKDEKTLHNFINQFRIHKYKSPNENENEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAB1</accession>
    <name>A0A9Q0RAB1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adp-ribosylation factor gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAB1"/>
    <dbReference type="OMA" id="INPEWAN"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="284" mass="33239" checksum="402A58800FC03DA5" modified="2023-09-13" version="1">MRRKKEDRRKELLKELRKTPENEKCADCQGINPEWANLSLGILLCIDCAGIHRSLKMKHKNVKSLVYDSFSSEDASRLLYIGNQNANKYWEARLSSRFVRPSSHSLDLLKQFIHKKYVIQKFISKSKPPPHKIFKKLQNSQLELSKHFLKKQNPNKKPVENLIQKVQPKNEKKNLIDFSLDKIQSNKETQENQEKNVGLNHENVSNDKVEEKDQKVANEKQTENEKKEGKDENPKNESNSILSAFYSGFNLKEKENENENLHEDLKEIDSKPVSFEYILSLYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAY8</accession>
    <name>A0A9Q0RAY8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAY8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5072973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="521" mass="60438" checksum="6FE7A2AB852F967D" modified="2023-09-13" version="1">MINYFLKAFESSQQTIFSHELSFMKIILETFVSIVKNAFTKLPSLIISPYEFDSFLRSFCRIAIREQHYYQKHEKPQNMEFKDMFFPVIDDIFLLIPSLTSSTSYKNTYLLWTHTFNLITAIVFPDIQSLYSSSQKDTNKTSQLNQSPVTFDTQFFDPSNNSSLAHAPTKLSQFEFKLFENEDIFSLENIDPSPNPCFNISLLSQAIRTIQKLFLNSCPHQISVKIFPKMSYILTSLMLLNKNYSGFSDVSNSATLAFVAIVKHIFENQQKNLEQQQEDFVFLRKKVASTLENCLFSTSKLTKISQMEQQIDQQNIELFSLFDFLLPNFLDSDPTVQSNLLNLLSRGVSILISDTFTPQNVPSTQRNLAKHCLQLIVHWIQELSKAKNKNEKQTNAETFLILTFLEISALLLTKFSETEKNNPNIKITIDHPVSILEYLRDLSLDPFSLKIIRDKSKQLGQEFPSFSSLLLSNKIKLDFKYEGEAFHLYSLFPVFCECLNTKFIRIRELLQQIFFRISKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBI4</accession>
    <name>A0A9Q0RBI4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBI4"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="467"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="732" mass="85575" checksum="064C3463A78C321F" modified="2023-09-13" version="1">MSKFHSPFKHRGQKQTKTTFSIAFTSIYHLALRNCTVWIQWKRGSHSGISKKSFLDKYGHTSWSDEFKFPATLFKPKKTDILEPKNLHIFVRLDKEQKKGSIIIGKLVINIAKFFNQNEPVVKEYKLNIKNHLQHKFHPTIIICMQMIKEIKLEKIPQLLSNPKIQQQIKELESFHNKLLSQDFTEEEYTELTNKSSLGTETTTSEHEKQHNNHHYNQIILNENENKNQKEEKSNNQKNNNKMISNNNPKQGINIENIENIANLENIEKKKIKQTSKISHEKIHEKTDYVVESLFSDAKNGISKRTNEDIEQIINHQSGLIEQLKKHIDNLEHQIEVHTIIEQERWLIDRLFYFTDSIYSNGVPVPASLMMKFFLFHNAFDQRNEKLLAIFCECFELLVQAQKDNKYNLVWLLSNISFMIRLLWGLFPQIIEEEFKKTSEILSENQNQKQEMDHSNLVVFMDKSNHEQIVKFHKQLISLALNIFMLLIEVIQDQINSKLTRDFLIHKPLGQTPQRAPKQKGLTSINHLDELAALLKENYLPKSIIAKIFTHILHNINSVLLIELMNHREFCHSANGFQVKISLSFLESWVSNVELSELNQELAPIKQACDCISMNKIIIKDLVNNYSVCNDICPKLSSSQIHKLLSNFIPDEIDPEPLTKFQLQEFENFSSHSIEKKKSIETPIIENSDFFGIDRSIVNWDQTPVPILIRKNENLTFLKIPLKELIEDGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBK3</accession>
    <name>A0A9Q0RBK3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rap gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBK3"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="280"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="504" mass="58672" checksum="810AA79822FFC397" modified="2023-09-13" version="1">MTQKDSDFSNNLKINQEKLNKNKKNETEKNTDQFLSKNNDNHNKENISDEQKKKQVIENHKDHTQQVSINVTDFDDQQNKDNEEKSPTRHYFRKDISKDSILEATETRSEFGDSEFVDSDEYTPLIHIETNEVQQILHGPQFRKFEDLFPIFQETKGWIIENKTEEAPSFELKEEYPFRDNYKGKEYANYITKHPDKGIVLVSVYEAKKNDKDGFQVFIWTENGNEILHLSKSDIDIPIFRSIFCMGPSLNKIFSSFDPSFKNLEILTCEFGNTEDEGLLLQIEDSKNIKKYKFGVVYIDDTITSEEEIYDYANGSHEYDEFLKILGEKVELKGFKGYRGGLDIKHGTNGTQSLYTVWKEMEIMFHVATLMPTNKNKDILRIEKKKHIGNDLVVILFVDGNEKLKPDLFLSHQIHIVIAVRPFIPKNSKETHYIVQVAQKDIIEEFGPFPPSPPIFNKSNIRDFLLAKACIGERQTTSSGIFASRFQKYIRSVLESIFEKYDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC36</accession>
    <name>A0A9Q0RC36_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine exchange factor for rac 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF114">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="475"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="687"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1486" mass="173910" checksum="3DD1B14D9014DE12" modified="2023-09-13" version="1">MSWDQIQIQKFTEWTNRYLNRRDLEVNNIETDFKDGVLLVNLVEEIFGVNFRYSKNPKLRFQKIENSSIVFTFLQKKGISTTCSPEDVVDGNSKRTLGVIWSLIRFTEKKDTKPLIKSPSQKQIEQNFKARTQFVKQKINQKKVTNVRVIKTKKKEDNIKKEDNIKKEDNIKKEDNIKKENEIKKEDNIKKENEIKKENEIKNKTLSLEDNKQEILSYQEQTPRQEKKHIFTAIDEISSHFIREAMKNQEQIKQKTGKKERQKETVDLDDGTQDEKPKQPQKLKLSVWEQKIQNQKKEAENSNIYLYKRRTVKSKARVIERGALKIRRQKMDSNILSKSKNFQENKEDQPQEINEDKIEENENEIEEDKNKIEEDKNKIEEDKNKIEEDKNKIEEDNNNKIEEDKNKIEEDKNKIEDNKNKIEEDKNKIEEDNKNKIEEDNKNKIKENKIEDNQEKETKSIVEITEEKKQQMKEKRREIAQEIYETEKSYVKSLEILVNIFLIPLRDGTNILTKEQIRSIFSQVEVILNYNRALQIQIEQRWQGWSETSMLGDVFKMMGSFLKVYTDYINNYNNALQTLSVVKKYKDFQNFLEKAKKNPETKMLGITSYLIMPIQRIPRYVLLLEDLLKNTLDTHPDYVDLSEALKKIREVANYVNEKKREAENLNEVLLIQDKVSGLDKIASPSRRFVREGKLQLIRGSKAINVQIFMFNDLLVIAKISGSKLRFMYKIDLDGYTRIFLPGNLILEMIEELGESKKSRKHAPDLIFSLSNEKSNIKVTLAASNSKEQLSWIVAIDDAISGVIENLSIKKEFRSKDLLKNNNKSDELLSIKEIRSKTFQAPLQNTLIQYKAIQSQETKITNVFLLYEKLYFFRSESDQAPKTIFSLLECNVSLLPDLKGFQIKTQNRIYYLSSGNLIGALEWINQIRSNLMIFLDQEEKKRKEEKLNLQNNQELKSPQKEEKEKDKNKNKENIKENAKENIKDQKNNESKTKTKAKAKAKTLKAKKSNKKNHKKGKGSTSSSTTSSSESGKDKESKKSIKFGAEVMLPLKDDKPKSKQQKQKEKQKQKQKQKKQKQKQKQQKAKSKSKAKLKSQLEQLPQIPKGKLARSVSVSKSEAHNTELIFKNENINQDRSRQIVTKEELNKFFTKDRKKVDQSKETPQKEDQKKIKPIQESQIDNKIIEQKPKQVEKPKQIEKPKQIEKPKQIEKPKQIEKPKQIEKPKQIETPKQIEKPKQIEKPKQIEKPKQIETPKQIETPKQIEKPKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSTSTSTSVSSEDNKNKLNEIKVEPKVEPKIEPKIEPKIEPKVEPKIEPKVEPKIEPKIEPKIEPKIEPKIEPKVEPKIEPKIEPKIEPKTQIKDETIPKQIETPKQIETPKQIEKPKQIETPKQIETPKQIETQNKLKNQNQNQNQNQNQNQNQLQFHLKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC66</accession>
    <name>A0A9Q0RC66_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dtdp-d-glucose 46-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC66"/>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="121"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="460" mass="53999" checksum="7E53C78870C5140A" modified="2023-09-13" version="1">MSQINQNLNINQNQNINQNQNQNINQNENQNQNQNLNQNQNQNLNQNQNQNQNQNLNQNINQNENQNQIENQNQIENQNQNQNENENENQNLNQIQNENLNQNQNINQIENQEIYIPQNILITGSAGFIASHVTVYLTEKYPNYKIFAIDKIDYCSNEDYLEEAKKKKNFKFIKGNILSSDLVNFIIESEKIDTIIHIAANSDVDSSFFNSLDFTTNNIIGTHILLEAAKNYKIKRFIHVSTDEVYGDSLSENQKFTENSKLEPTNPYSASKAGAELLVQTYYKCFHVPIIITRGNNTYGPNQYPEKIIPKFICLLDQNKSCPIQGNGSNLRNYIYVDDVVQAFDILLHKGKIGEIYNIGSDFEISNLNLTKILLKKFHLENQEDKYIRFVKDRPYNDIKYTMDTSKLQKLGWKPKIEFEEGIDRTIQWYKNHMQNWKFWENDLPKRYPKKQKEMNFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCE6</accession>
    <name>A0A9Q0RCE6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCE6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="449" mass="51981" checksum="B50ADEAEAD32E4F9" modified="2023-09-13" version="1">MEILSKRFFNNIILTGGTTLFPNFKERLEKEIKQIIPDKMEIKIIADPDRKYSSWIWSFGFENSTSDSDGIFGDSTYKLTETNSQFISNQNNYKAINTRNIIGNLINESNLINLSKSQYIGNEAQENKEILNLSYPIQKGIIENWDNMEKMWHHIFYNELKIAPEEHPVLIADSPFNPKSSKEKIQEIMFETFNVSGFYLANSGILTLYSTGRTTGFVFGIGHEITFTEPIYEGYESSNIIDQYQFGGNDLTNYLIKLLKEQDYSFDKSNDTEIARDIKEKLCYCSLNFQQELNQNETENQNQNETELEDIYELKNGDIINISNERIKCCECLFEPKIIGIDLEGIHKLIYNSIMKCDISSRKDFFNNIILTGGTTLFPNFKERLEKEIKQIIPDKMKVKIIADPNRKYSSWIGGSILASLSTFQNMWISKELYSESEDEDMMSYGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCM6</accession>
    <name>A0A9Q0RCM6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Interleukin-11 receptor subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ASFYEIQ"/>
    <dbReference type="OrthoDB" id="5984158at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040377497" evidence="3">
        <location>
            <begin position="23"/>
            <end position="2462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2400"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="290"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="934"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1569"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="2302"/>
            <end position="2393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2462" mass="272591" checksum="64EAEB2DDD74634A" modified="2023-09-13" version="1">MKQNKLFFILIFLSLSITIFNSKTYQITEKQKAKTNFHKIECIPKDFNQKNYQEKCGKEISVSKNLILIGFPEASIGNNKNQGKVYVYRKEGSNWNKEATLIASDGIANGYFGSSCSILEDDILLVQTKGINSNQNSNQNSNLNSNQNSNQNSNLNSNQNSVYLFKFNGKNWIESKIPFSNLQNYLNFHEQVTPDNVTIINCTTLFSSFECYWYNVSQDNITYKINYNGDWNIIQNPEVQDNTLYQIFDSSNYPNISGNENYTIQIIACDAEDQCGNSTNEVNLTTRIDSVKNLSAITLSSTSIDISWNYPNVPIIEGVPKLDHYAISYSLNMEEEVGDATINNSSTSYNLSNLNSGSNYSISIWACQTSECQGDSKGEVSTISNTTIFGQVNLSCSISDSFTIICSWDEPNGTLSPSFYNFSYQSQNGEDIGSLNLTITNETITANYSNEEYYIYVSACDINGICGDVSNTTVNTLIFGQVNNLNCSISDSFTIICLWDEPNGTLIPSSYNFTYQSQNGEDIGSLNLTITNETITANYSNEEYYIYVSACDINGICGDISNTTVNTLIFEQVNNLSCSISDSFTIICLWDEPNGTLSPSSYNFTYQSQNGEDIGSLNLTITNETITANYSDQEYYIYVSACDINGICGDISNKIVNTTIFGQVNNLNCSISDSFTIICSWNEPNGTLIPSFYNFTYQSQNGEDIGSFNLTITNETITANYSDQEYYIYVSACDINGICGNVSNTTINTTIFGEVNLSCSISDSFTIICLWDKPNGTLIPSFYNFTYQSQNGEDIGSLNLTITNETITANYSDQEYYIYVSACDINGICGNVSNTTVTTTIFGEVNLSCSISDSFTIICLWDEPNGTLIPSFYNFTYQSQNGEDIGSFNLTITNETITANYSNEEYYIYVSACDINGICGNVSNTTVTTTIFGQVNNLNCSISDSFTISCSWDKPNGTLIPSFYNFSYQSQNGEDNGSFNLTSTNETITANYSNEEYYIYVSACDINGICGNVSNTTVTTTIFEQVNLSCSISDSFTISCSWDKPNGTLIPSFYSFSYQSQNGEDNGSFNLTSTNETITANYSNEEYQINVSACDINGICGDISTKIVTTSIFGPVNLSCSISDSFTISCSWDKPDGTLIPSFYSFSYQSQNGEDNGSFNLTSTNETITANYSNEEYQINVSACDINNHCGDISTKIVTTTIFEKVNNLNCSISDSFTIICSWDKPNGTLIPSFYNFTYQSQNGEDNGSLNFTLPNGNTTAIYSNEEYYIYVSACDINGICGNVSNTTVTTTIFEQVNNLNCSISDSFTIICSWDEPNGTLIPSFYNFSYQSQNGEDNGSLNFTLTNGNTTANYSNEEYYIYVSACDINGICGNVSNTTITTTIFEKVNNLNCSISDSFTIICLWDKPNGTLIPSFYNFTYQSQNGEDNGSLNFTLPNGNTTANYSNEEYYIYVSACDINGICGNISNTTITTTIFEKVNHLNCPISDSFTIICSWDKPNGTLIPSFYNFTYQSQNGEDNGSFNLTSTSETITANYSNEEYQINVSACDINGICGDISTTTATTSIFGPVNNLNCSISDSFTIICSWDEPDGTLSPSFYNFTYQSQNGEDNGVFILASTITNETITANYSNEEYYIYVSACDINGICGDISTKMINTTIFEKVNNLSCSISDSFTISCSWNKPNGTLSPSFYNFSYQSQNGEDNGSFNLISTITNETITANYSNEEYQINVSACDINNKCGDVSNIIITTSIFGQVNLSCSISDSFTIICLWDKPNGTLIPSFYNFTYQSQNGEDNGSFNLISTITNETITANYSNEEYYIYVSACDINNKCGDVSNVVVNTTIFEQVNHLNCSISDSFTIICSWDKPNGTLSPSFYNFTYQSQNGEDIGSFNFTLPNGNTTAIYSNEEYYIYVSACDINGICGNVSNITINTTIFEKVNHLNCSISDSFTIICLWDKPNGTLIPSFYNFSYQSQNGEDIGSFNLAITNETITANYSNEEYYIYVSACDINGICGDVSTKMITTTIFEKVNNLSCSISDSFTISCSWDEPNGTLIPSFYNFTYQSQNGEDIGSFNLAITNETITANYSNEEYYIYVSACDINGICGDISNITINTLIFEKVNNLSCSISDSFTIICLWDKPNGTLIPSFYNFSYQSQNGEDNGSFNLAITNETITANYSNEEYYINVSACDINGICGDISNITINTLIFEKVNNLSCSISDSFTISCSWDEPNGTLIPSFYNFSYQSQNGEDNGSFNLAITNETITANHSNEEYYINVSACDINGICGDISNTTIDTLIFGPVNNLSCSVADIYEIICSWDKPNGTLSPSFYNFTYQSQNNQDLNSINLTSTNEKITANLANEEYYINVSACDMHYQCGNPAETLIWTQNEPSTSNSKTVIITISVIVPVFIISLIVVIVLLQKRKRKRNDEKELIEELLNNTDDDLLNDSDDLDESIKSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDA0</accession>
    <name>A0A9Q0RDA0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDA0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="444" mass="54438" checksum="45443A97565403AF" modified="2023-09-13" version="1">MSHKQFMSFQFENIYKFPKNTELIKDDSLSEGEEDLSLKFIECIPDEVLFLIFEYLDKPFHLGICSCVNYQFNKVAENKEIWQKIIKKNINLLDFDEIKLANDKRTFYINNSFGLKQYFSSNSKINDENFDILNEKNDLEQKTENLDPKIQDFLIQFDQNPKSFFVNQLKKYQKVKKKRDKEERKFKRKENWEKFKYFLEDNRYFFLLLLIVIQLWLISWKLESKKSFWILIFLPSFLNIISFRYLGFKDDVEREWCWEFIRNSLNIDGLILMFLSVKLDFFSQFPLYIIVMFIWFTFFYEIAFLFKINWIDFKWELTENLFIIIAILFHFLIGFFVLFAFLKIDYQKNFDWDKIFIPLFILNAVVFLQCFALGCGYYLDYTFNNITYWFSLFLIFLMLFITEIFTLLFLLKKWEINFYFILFPLSLLSSFCLIFYIPFKIFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDJ4</accession>
    <name>A0A9Q0RDJ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Wd-repeat protein bing4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDJ4"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="355"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5076179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="438" mass="50785" checksum="F87DAD145B3CE292" modified="2023-09-13" version="1">MNFKVFENKKLQKEIKELKERQNQIDEEIETKSKKYERGKATKTKRIQNKKLKAKLEHSEDLFHEAAINSAKMELFVQKTPGYIEAEKEDEETYKTKQKEIAEQIEIGSRHKNFKLELPKLGPYRIKYDRTGRYLLMGSKLGHVALLDWYRSSKKCELQAQEAVRDVVFLQNEAMFAVAQKKYTYVYDSNGVEIHCLRNHQDVNRLEYLPYHFLLTSIGNSGYLKYQDVSTGTVVAEIPTKLGPCYAMKQNKHNAIIHLGHSNGTVSLCSPNLHKPVAKIFVNRGRVEDLAIDDTGRYMATSGTDNSIKIWDLRKFHYLYSFKKINSPALSLDISQTNLLAAGFSNKVLIWKDWINEAEKEKMEIVNENSNEISNEIMNEILNENTNQNLNQNLNQNQNQNLNQNQNQNLKSKSKSKSKSKPKKFYIPFNSFISFPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDS3</accession>
    <name>A0A9Q0RDS3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDS3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="442"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="605" mass="70915" checksum="8668A678AD36EB43" modified="2023-09-13" version="1">MNEILFFGLNKNPILIKNGLYEITKPIQFKFENENENENENEKQIKQISSSEFSTIFLFKNGKAIEYLNQNDSNQNPSKIQIKNIQKVTVGFHNESILTIEGNVFAKGKEINPKNSKEFISISSLIEDTNDRIIQDTVSGYDSIYLLTSNQNAYGIGLNFFGQLGFDSGTLKKTTKPILMMKNISKIFSGNISNSVFLLNSNQELFVCGDNVYSQLGLGKSRKEEKIQELTQIQNIPKGKIIDIQCGYSHSIMLVENENENQKENFIHLPNSKLIGFGGNYYGQLGTGDTNNQPIPIPIQIELPKLRFNENISNYHISCGFYKSFLYYSPFLSNLEEDLIKLFRRNEFCDISFKTKNGEIIKAHKLILKYRLNQNENQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYLEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNKIKNGIQITKEIIDEIKIGIDYFQLNQKNPNLFDLLINKFNNQNLQLKLKEEKEKEEEKEKEKEKEKEKEKEGRKKKKEKEKEKEKEKEKEKEKMKKKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REA7</accession>
    <name>A0A9Q0REA7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sap30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REA7"/>
    <dbReference type="OrthoDB" id="10580628at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="92" mass="10846" checksum="E3A334789076F216" modified="2023-09-13" version="1">MGRDFQQKKKRRSSRKSNSKYSSTHKTVIDFSQLDVSTLNQLKQFYKIKADNKMSKKQMVEEITEKFCQEVVNEQDVISKFFEVISTNSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REE2</accession>
    <name>A0A9Q0REE2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tether containing ubx domain for glut4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REE2"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17075">
        <property type="entry name" value="UBX1_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059238">
        <property type="entry name" value="UBX1_UBXN9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TUG ubiquitin-like" evidence="3">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="651" mass="77498" checksum="27B400DCC105289C" modified="2023-09-13" version="1">MQKTQLIIQINPKNSIEIEISANESLSKIIDMICKQNNLKQSYQLKYQDKIIDSSVPFKMTNIPNKAKLELIIDEKSITTKKSIKIALQIDSKRVSMDFFPTQTLFEVLYSFEKDYNIFHRKFDLNENEQKWNQPIIIYMNKPIEGPDLMRKTQLKSIGITSGNFMFRLMFKKTDITLEEAEKRFRLNELNIEDLNEKSNEKSNEKSNEKLNEKSNEKLNQNSNQNSNQNSNQNSNQNSNQNSNENLNEKSNQKSNQKSNENSNENSNQNSNQNSNQNSNQNSNQNSNEFLDENSNQNSNQNSNQNSNQNSNQNSNQNSNEFLDENERLEKIKMQIEETQRLENENALRLLEQEKQIQQQIEQIEKENEEKARLEKEKQREKEEKEMKEFLEKMKKEEEEEKQRKQELINKFDRKIVLIQPKTITETEEFELDDEFFIPTKKDFKEQFHQLEKQLQKSKKKAINKEMEEESTMKFSEVMIRFFFPDQYQIQASFLPFETFQDLSIFLKDQIFRQEFKNIFFYLYTSPPVNKYYGEKNKSLVELRLAPASRIYVSFGANNVPTLGLISNQIIENYSDLKNVEIPEIHFKKLPKENQNEKEIEIEIEIENQIEIEKENENGIEIEKPKKKKNNNLKNLNDNQLREKLQKFFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REW3</accession>
    <name>A0A9Q0REW3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-secretase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REW3"/>
    <dbReference type="OrthoDB" id="9997853at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="2">
        <location>
            <begin position="780"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1038" mass="123208" checksum="68CAF80BA6A67FF7" modified="2023-09-13" version="1">MIALNLFSTLFDAIDQVPPFIPPQKKNEKNNLTDKNKIMNKPKQEKEKNQIKKKVQKASIYSPNQNESRKFLYPSSLFHVDGKPMKNTCLIGYSTTGKLLISRDCENDGKLVTYIDLLAFNPLKRTNIYQHSTIITCVSASLNHDETLLLLTELIHRKKHSQNGNQLKTETEDTYQLHVVFLGENPKSQKILQENSLFQLGVFLPNNYGKSYDTFLFLVDRESVRKYRINFKKKNNIKTFTKINPKEFLCKEFIWYELNPVRRHLLLIRKKGNFYELIVWDFQIKSSKPQMNWFLDIPFIYQDERKIPFKYDHSLFTTGFTSPNIYTNFEITFVSNRITCLCFQSLPENLTEDSEKIIHVTIWILERNERLSLEIPLHGLSKEFIEKTVVFFGALDEMLLIYIPGIYMNFLDCSWMHDTSDSLLLTNQEYPNFIGKSIFSEENSPANISRIFADIHFRFSSKKTELLERLMIDNKTLSIFSYKFDQNGLIKILKYSQNEIVHTQVLHIAFFHVLEDQFYDTVLSYLCQQSPQSITSSFIQEYIIGSTYYSFLRRGFKQEHENTRKYLLSIIPLSTILTYKQIEDQKKDPENLSIPLDYKPNFFNYSSVSQTSKRIERLTYQKLHKNASQFLSQDKKPIFNSKEQEQQAEQKQSQKFPTEYQQQTQQNEEIKQKENFGYDEKYSEELLLQIVSAHLSHFVQMPVVLLQLTDFYLKIQSQEIEKLFIKLSDLVKMKFPKNHNDFGMEMIISNLDCFELFQKYLNENQNQNLNQNEMKNLFVNFKYEIGKKRREAFQVFQEFYSAIEGFPVPFPKDFHFHYCRLALYLIFIQYLDSQIIQIDYDFVQQILSKLGETKREIGLRNRLISHIFNFESFIKIVKKYPENERYVIEYFSNEISKKFSNLIQSENLTETSDFQKSNENQNQNQNQNQKSNENLKSNENLNQNQNQNQNQNQNQNQNQNQNQIQNQNLNQKSNQNQNQNQNQNQIQFQNQNQFFVLSLVLDNLKEIIKKEENLKIKEINSINFIIQNAEKTFSNEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFY1</accession>
    <name>A0A9Q0RFY1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFY1"/>
    <dbReference type="OMA" id="KESTQCY"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="819"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="864" mass="101305" checksum="2B9633ECECCFA270" modified="2023-09-13" version="1">MEINKIELSFLEGFNQIFNNEELNIFSENFKQILNEIKNSNFETLFATNKFIEQFLYKSFSTEKITEETIEKYKIFLKEKIKEMINENKQKEYEIQLILLLVGIGYLIMFIQNNFIGPSLNSQEFIQLNQNFVIEYLMIDGEIPFDKAIILEYLIFAKIILVDCEDLHNLCQTTSIWSCRCLYIYQQILSGPSPHLKNLITERIPKYSELISSSQNNNFIAKMKMEKAVLYYTYSQFQEFIENIEEAQKQTGLELNLIGVNGVRTKFQTFETPQLVLTAISKDYQEKKEEINLNVPKIIENPDDTLLSQRKLTLKEDSKEKLEKLISGNLSPIDQAIIMNFFMNMKKNTPIDKLSDEKLISFLERIQNNPNNFVIHTLCLFEKSLIESKKTRTAQRSILQIEEILSTINLNQYKTTNTNSEEKQENEQNQVNFNQRMDLFFCIPFPTVWDMIRELGNLFMNFGAFQSALFLFEQVDMYEDLALCYSAVGRKEDAEKTILKLLDKKETPNLYCILGDLTDNIEHYHQALKKSNYKFARAYRALGNYHLKDENLKEASENFQKALEINTLYPNIWFFLGYCQMKLGNFEAAGNAFSSVVAQTDDNGEAWNNLALIHLRLNRKKEAFYALNQAAKFSYQTWNIWENLFIIASEIGEFASSIQALNRILDLKTFPKFDPNNSQPINYQTLSKLIDSITSEKESNLIQDELKKRNLKDLLGKAVKRITELIIYDDVIWDLCANFYFNTQNLKDCFKCRQKQFVATQKSGWNSNTKQFHTVLDSALKLQSIAILLSDSQSIYSIKLELKSLFKKSNQNFFSDPRLSELTQAIQELEELEEKEKEKKKKKKKKKKKKNRLKFFFFEFQFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGQ1</accession>
    <name>A0A9Q0RGQ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGQ1"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="677"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="710"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="743"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="807"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="884"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="971" mass="110404" checksum="22F0419CC22CF6AA" modified="2023-09-13" version="1">MDNLVGYLQNFRYTFQDEQELSTVEKQLYDLIDRAQQDPFPGIENPPPKMAKLLHDFKANCIEWFNLTKKSRKRGPIFLPKHLYNFQRYIQKFQVEMFEFSQTLINQNSDDPKTKSISKALEFWHSIPGKRPTDSAVLFDDFIHHYRASYSVLSIYAIDLLKEFMSAFVFQVTFMKVVEVFGFPFRNLSACKKAKCQKFELAAFGISKNCLYCQHPKEDHYIFPKYDLSNPPETPKIYEKNPAPPPGMKDIHVAVLRNDEKEVEKIIKKDKKVLEERTEDQSHMMPLTLAGQQGMKRMIDLLIKSGAKDIPECFFEAAKSNQQEIVLELLEQFPFLMKATDGNGETILHILTEDYDKEDLLKKILARKMDISNTNTQGKTALHKAVENNNPNAVKLLINHGANVNARDHKNITPLIQSVISSDDHIIDPQIVEILLNSGADPKCIDIENKTALHHAIIGNAPKEVIELLFKKSPETLSYIDKSGKTPVQYVIASGRKELFPLLAKFANITKKQSLLDEAIGNSQFEFAKQLLKNNQSSNEISPESMQIAIKSGDEELFHLLMDKGGPIDWVSEPERQNIIHQMTDSGFQFQKLYPKIGEVPLEVQEAENQDTCLHSAARKNEVELAKRIIEEKPSLVNFQNNQNETPIHTAIETGHQEVARVLIDSPEARLEMKDNQGETALSKASRLGQLEIVKLISKKGVDLNAVNKEGMTPLYQAAYFGHYEVLKNLIKNGANPRLTSRERWSPLHAAVHQQHKDCVQLLIQNDCPIDVANNALNTPLVFAAESGNLDILVFLLDHNASINLGGDWNPLTIAMKKGHTEIIKVLLKRGADIYRVDPEVNYECPNYLAMMLRYDGDEELWNILFSINSKMANFHGNDAFIPTPVFTAAVYKRIKTLKILLNHGADLKKKNSRSETVAEYISNFIGYEEILKILGVDEILTLDGREKIEMKISDLEDLLPEVPPHPDNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGR4</accession>
    <name>A0A9Q0RGR4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGR4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="130" mass="15541" checksum="52159616E12F026F" modified="2023-09-13" version="1">MFASLLEIFPDSLKFYIPDFCLIQKLFFFKCTGLLAIDFSSQTSVTLFFQHPSDFIKTNQQNENSNQKFNQKFNQNFNQNFNQNSNQKFNQNSIKISIKILKEKIEKILQENLLLFLQQKKFLKNFQMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGS2</accession>
    <name>A0A9Q0RGS2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14354</name>
        <name evidence="2" type="ORF">M0811_14360</name>
        <name evidence="1" type="ORF">M0811_14468</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000030">
        <property type="protein sequence ID" value="KAJ5079512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000024">
        <property type="protein sequence ID" value="KAJ5079618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000023">
        <property type="protein sequence ID" value="KAJ5079633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGS2"/>
    <dbReference type="OrthoDB" id="2278877at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="139" mass="15977" checksum="22755C3A68E42E4A" modified="2023-09-13" version="1">MGELLQTPYRISITRNTAPLSSSIISFYGIHCTYILAPYHISRFIPFCHYRLPSFAPIATFDERFARQYRYELPPNFHPVSFYAAIVHHLSGPNISTPWSVFQDGRIHKITISSPISLSFQSSFHLSITFLLRVQSQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHB9</accession>
    <name>A0A9Q0RHB9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_14169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="JAPDFW010000014">
        <property type="protein sequence ID" value="KAJ5080082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHB9"/>
    <dbReference type="OMA" id="GMVPQVW"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5080082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="191" mass="22693" checksum="1FCB96E544A91D48" modified="2023-09-13" version="1">MFGIFATFLILITIYLFFHLSEVLLTYIYNPSHLSWESTLITWDYTYSVLGGLTEYILSSFFISSFKQNSFMQILGLLLIIIGELIRKVSMITAQHNFTHEVQEEKRFNHRLVDFGIYKYIRHPGYLGFLIWACGTQIFLCNILSPIAFAIILWKFFNERIQDEELNLIKFFGDEYRKYRSKTPTYIPFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHK0</accession>
    <name>A0A9Q0RHK0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transducin/wd40 repeat-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ATKMQPN"/>
    <dbReference type="OrthoDB" id="17063at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38709:SF1">
        <property type="entry name" value="DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38709">
        <property type="entry name" value="SI:CH73-193C12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="844"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1211"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1211"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1317"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1341"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1633" mass="189675" checksum="A089095170BC0CDD" modified="2023-09-13" version="1">MQVNQRFFLKDVQICSFHPTKNSVFIAKGRTVEEYDLITGAKIITLIHASEPITHLEHSPTYTYLIASLANGVILVWDSSNYTLHLKLSPTKSDERKPVGCISCAFTSPNLLYSREKKGTVKIINLESANLYQLKNKNNKIEVSKQPVIQIASHPFKNAMATLSLDGLVRLWEFQQKQFYYVIDFYPIFGDLQKKKHNQKKINYKSICIRFSPVERDVLVVGGTKGFVSFWDVRNANEAKFITSYFVPPRSPITSITFHSILPELFVTNEDGKITALVKKNDNLNSVSISRNFLDHCGIPLSYFSILHEVVCHYLNNFVVIIQKQDQRQNSVGIGVYDIVDKNFAYSLFPNATKIQKPASFFLVPQQPFEFEKDIYFIAKDSIYAFSLVEQKNQGRLHIKCGIPRKCLKRIRAGQITKFVYNHNLDCFLIITNSQKEVKIKKPDSFQEDLSKETAENNLDSNTIYSTNKEDSTTEVVNESRFFLFDQTGQNYSGAGIDVIFIKQDSEFLVLGMDGKQLIQCQFVGRTIEFRENSSIQLTHVISSIFSTPLNNYSVIMFYHSTNNQIMFSQNYANPTSLDPYQISSKYQTSLATRMQQSKSFMNLNNPNKKSSPELKLNSGEVVYSVNWQIPGRIQTSFFAGIITNQRLLIVDEELNVVNFIKTPPKTTIPYFRSCIWVGFTLIYSTETHLGYLTLDNTMEPVVISSLNSTNTLISGILADRAIYAYKQGNNIKITEQSLGLFEPLIAGLVAVPEKYWKFQNYRDFFSISIQKLARIFEVHRTTSRFLEYLDQKGFADISLHASSIVKHNFSKEKQFNFAMNSQKFEMAFDIIFSEYKKHNFEEPQFNKKLKEKKKRNEKQQPKQEDQNQNQNQNQNNENENQNNENEKEKEKEKEKEKEKEKEKEKPILVTKLPQKAQSQIDLNEYSDFEESGDELNLELDYPKNNDSTNLNINLNPNPNVFSNENSNENPNENTNELNEWNPNQKIEKQEQDNDEQFVRHFNKEKLKLKLRKLGQEAMKYGNFEIARKCFDILNDYETLFIIFSSLNEEAEVAALLFRIYHNTYLDKTLKNGYLSLCSLFINLEKNISCDDNEMDVRKSLSKYRVNFQTGQLFEEKKLKVFGLKSTSLNQGEEEMFNTSVDKVMIEMRIEKEYSSPDPNENIIKPLLLNKFESWITIPIMNLQTEIDYDENEDKYLSANIGVIRTEEKNLEEEKKKEEEEQKKKKAEEEKKKKAEEKKKKEEEKKRKAEEKKNKPKEEENKNLEENKNLEEKKNLEEKKNLEENKNLQENKNLQDDKNLQKNKNLQDDKNMEKKETHHRHNHSSKNKSNERKIRLKPPSNQLKNQNSNQNQNQNQNQNHQNQNQNQNQNQNQNQLKNQLKNQLKNQEKFKTPIEAFKSGVQNFRVMDLEQSKLDLETSINLMREKKGGDPTKIQKSIKWCTTYLLAVKITAKMKEFETLLQSSNHEENIKKKVKSAIALYSILMLGLSLESTDLETISKFAIAKSMNAENFDIAARLILQMMKTNPPFMDSLEKRLEMCKSYGLQNGSPVQYLCPNCQKEIVIKLAVCPNCNSPIKFCYSSLKLLGFNEKQYLDCSYCGSIFASNLADIKEGSKCPFCKMKELELKNFEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L572</accession>
    <name>A0A9Q0L572_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein rab-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000142">
        <property type="protein sequence ID" value="KAJ5066487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L572"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="314"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="422" mass="49893" checksum="136C598884F45D15" modified="2023-09-13" version="1">MSNTKQKHFGRILFVGREEVGKTCLIARYCEDKYKNDPQPTIGADFSTKIIEIGNDSYVIQFWDTSGREDISELITRFFPQNQASALCYDITNRTSFDEILSFKQRIEKSQKGNTIFFLIGTKCDLENERKVSKEEAQNLANQLGIKFYEVSAKNKININECFDDLINDILDVWDFFDFPDKNENIYLVDSITEDMKKFFERKEFCDFEIECKDEKNNQIIKIPIHKFFVQHRLKMDSNQFNNKFLKFVTETSKKDVEISLESIYTGKTENIPNYLIFKEFKLKFTEYLGTNYKFGRKELINDLKKLMNEETSKDFEIILGNETIKVHKLILIIRSELYRGMFLSVTEDKSNSVHDYSNKKPETIKTLINFLYTDEIPENLNKKIYQELIECVDYFQLNPKITDNLNKIIETVEKEKKCKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6F7</accession>
    <name>A0A9Q0L6F7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Potassium large conductance calcium-activated channel subfamily m alpha member 1a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_13177</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6F7"/>
    <dbReference type="OMA" id="YWCKQCH"/>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="14">
        <location>
            <begin position="289"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="590"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="605"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="679"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5067217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1135" mass="130825" checksum="0A278C5208954764" modified="2023-09-13" version="1">MNISESSLTVLAVIFVVGFLIVLAGAILYWIITKTVPMNTKGKCGSFLKSYKKFKNFLQHILRLNSKTGAIWEAFQNGCTLIAIILYIIQLYGTRNQKSFDVETFVAFAFALEYTLKFIISNSKVKYYVSRWGIIDFATFMPTFITWGMDKDEYGANMEAMRTLRILRIFKIYRLLVYFQKDINKQIAKVGMSIVAFITVTASFFIYIENRYLDSSDKLEFHDGIYFMVVTISTVGYGDISPETTLGRLFMTAMILVIAVIIPYQLSELTSLLGDVNPYIGAYQGTKEKRHVILTGQITPSSLMFFLSDFTRRKPKNRNIDFVILQRKKPAREIETIIESPTYVEDIKWIVGSSIDDQDLQRAGIHFAESVFVFVDKFSEDPKTADTKTLLTLLAIEELNNFSRIFVQVLHPEKQVSLTKDAAIISILEMKGYLLAQSCMCPGFSTFIFNLITNTLDTKQPEKWTQEYKVGRNMYIVTFLFDEKFAGKSFIEVSIDFQQKGVCLFALLMEVENRHVCVLNPGLSYNIQEDDIGFLITSSESDYIRLLELEKQKNLIFHDKSESFTKISMNSINLGVMGTLKAFENEDEKHKQEIDLENSFSDTSDSVKENEIKKEEKNNENKDNDENKDNNKDKDKDNDENKDNNKDKDKDKDKDKDKDKDKGVTFDTTVYDPQLNSPLINQDLNQNQNQNQNQDENQNQNQNQNQNQNQNQIQNKLLHKSSKSKNFMQRDPYRITEKFRRETLDQIEISEINFFDDDDLDLKTNEQDIPIPEGNLRRVNTCERRPLNKSKLVACSGFNGHIILMGNTSGIAYFITHLRSVDWKVQIPIVILHPDFPESTWKEINFFPFIYYVAGNPTKILDLERVGVSHASRVIFLPENSRIHELQQDPDLGDFFADSETISTIRSIEHLSSKPFIITELLHSESMKFLKLKFRKQRNSISKLISNPTKKKKKNKWKVGKFGGSIVSRMLNLGGGESQDVYNSHPYFASGRVLLSSMMDSLLSYIYWTPELLHIISQLIFSKKFDHLDSEIQQSSVFLYKIPEIFNGKYFQQFFSTLAKQFGIICLGLYRSGKHFEEHSPLPYVFTNPPPDTLIYHEDSAYLLSSSLDLISDAMTQIQSQKISLEPFLINKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6P5</accession>
    <name>A0A9Q0L6P5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6P5"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="257"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="325"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="393" mass="44905" checksum="AD33DBD2E4AC3285" modified="2023-09-13" version="1">MEYLRGNDSNPEEIQIEENIQKVSVGYANEAILTIEGNVFAKGKDINPNNPKEFINISSLIEDTNDRIIEDVVSGNNSIYLLTSNQNAYGIGSNEYGQLGFEYKTLPKTEKPILMMKNVSKIFSGDSSDCVFLLNSNQELFGCGENFYGQLGLGESRRKETYIRKLTKIQNIPKGKIIDIKPSFYYSIMLIENENENENPKRKLYSCGDYLFNGLGKNRNENTNEFTEIKSSLFENDDNILDFSVGNSHTLILTSNSKLIGFGYNYSGQLGTGNTNSQSIPIQIELPKLRFNEDISNYHLSCGTFNSFIYYSPPSFSNLEEDLIKLFQRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNQNQNQNEKLQEIISKKSIKESNQIFEMIYSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7V6</accession>
    <name>A0A9Q0L7V6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G protein-coupled receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="LANTCYG"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040280675" evidence="2">
        <location>
            <begin position="25"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1515"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1578"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1655"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1710"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1786"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1816"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1848"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="3">
        <location>
            <begin position="1351"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2036" mass="230296" checksum="017F0128776998CB" modified="2023-09-13" version="1">MKLINFSFLIYFLAILFLIYKTNCAELPLPTNYEEIESNNTYYFVPGNTYSNYSTVNEQENINITCQEPLNEPTTFTGLIQFNLVNNTRINTSNCGSNLTFSAQVIVHTSNPVIFDHVNFSGKAQISSTSSFCYLYNCDISGVTRSVEEKFILSQDSSFLIESLISSNDNSFQNFDFSLSINPPKNITINNCDGNFNLIVDGISTYLSECVPLALTIKDTDVTITNGDLKMKNLTLYEDSSIFGDVLNVNESISIYGDASNSKIISASLYFNGTNFFSEDTKVEIQNNFSIFSSSCNFQTSDLFLIVNNTTLEINDSLTIRRIDFINSASLHGSATLQVSDNIFFNSSDTKTIASPLKVLNLNNNETTDNGLIHIYDQFFISTSLPSVHLPSILFQNSEVNLELYSQNGSTNYTMTILRTDRGTIIGNNTNFLVVTSQTTFNSDSILNNITIDSQNTKFTGNGSIEFQNSAQFYTSLANSEPGSLFTLFGNGSFIPDELIINGSLFFDGIFQGKNIQITANGKLEFSNVDSSVFNKTNITLNGYLTIRNSIIYDPLTNFSCDSENEYPLSIIDASLIFLENQPFLPSMKMENSNITHFNSTLKGLFLEGYNILNASNLTFQNGQIQAKENSESFLDFVSFSTVFFGSSSGFNLNSNSILTIFSSDNSTPYLFSSWTNNVFCYIVNDSSLKLQNLSFEMNANFIVDSSSNILVNQSFFKINSSNEDFIGTLYIVGFYSEVELESYFILKNLNISQGKFTFTTIRANETDSSLIFGDGTSNEVIINENTIEQSIIQSQGYIEINNNTIIHNIKFEMRDSSHLVIKTFNITDTKSSSKIENQGLITVFQNEPSLINEKKQGYNLNEEFDGIFFNFSLDNQQNGTLNFSDNIQFNQEFSCSGLFESANNMNFEKGLMLYGTGKIQGLRDTGINISVNGNLNISESTTMDLVNISVNGEMRVSGLEASKNISNSLVTVKSFFCYSNAHFGLYNSTLKVEEDYYFEDSCYLVSDSFSISGFHNYGNFSVESKNNISFDANFYNYGNFVASASNILFRKLVSYEGFQLNNSTLILLQDSVLNNSNAGIGSDFIYLTNSSFTIQNESTLTFYGNYIIEKGMKIDGNFEISENTNMNLRVESTNTELKINKPPIFNNNLTVELLRDSQNTPRTDPYNVIYLLSPFNFSLENLQTNEDQSTKFSQNGDWVIGNVQGCRKGKYSNSFDQPCQNCSEGWYNDEIGVFSCKKCPVGHFSDKEGQEECEGCSPGLFQPNEGETTCLECEKGTYSSGFNSTICTQCPLGQYNSEKGSSGCYICEAGKFSHNPTRCESCWPGVYSSKNASSKCDNCPLGKYNTQPESTSCSPCEVNTYQDESGQTSCHLCPTNSETNIYGASSIDDCLCSIGYYGLARETCKICSKGSVCDDVGIVNPAAEEGYWHSSSDPTTFLECSVKEACPGGGTDNCNKELGYSGSLCSVCLQGFYKFGNQCMKCPNNQKNRLVLVGIFVILLCLFLFIIARKVKNYFASFSITFSFFQILAVISGLKLNWPDSIGSTWRSISLFNFNIDYLAVECNLQLTYTQKWALCMVFPFILLLVLLVVYFFVFLHSKIIGKCGAGFMRKFPRFCSKPSRQTTNKYLYVFSWLRFKISQLFTHGFSKEQRKSLYNNLINSYTTILSFIYLFLSYKVLQIFDCKKQSEGTYTFGGDSSLFCYEKWWKDIFPFAIVFLVLYVVGIPLILSILFFVSSKKLDEQSFDLRFGLLCTRYTKTWFFWEIFVMIRKLLLTIAQLFLSFDPIIQSIFCVVVLLFALVLQIQAKPFIADRHNTLEFVLICFSEIILFSGMVFASNDFQQTSGKGILGIFIITLIWISFSTLIIMILFEIRHRVRVHKGKDIDEIQQSIDISSGQTILKFLASKPSFFLIWDWFLESSEYQNKIQREFFQQIRDYYNSKEIEKQKLKFDTFWESILIKWRDSFHLIIKSWFIQASLKEKIQFINLLSKIRFEGLLYCNSNYTKKDQKKTKTLTTKYFKQNQDQKQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8K8</accession>
    <name>A0A9Q0L8K8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8K8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="183" mass="21945" checksum="69077F04008E7A3B" modified="2023-09-13" version="1">MLFSSSFSSSDFEVSPNDFLPEIERDEEKIEESKQTKNFELIFQESSDSFEDFSINSSDLEDFENDQLDQTKEFLKRKFSTENCYKKPNDLTKEIVYQIQIHFPEKNWGFLYLSKNGIKIDLAKRVVNFAFDKTYIQVGFKTKHIRITNKQNFLIFSLFQLPVEHFVFYHHKFKQLHKLSNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9A7</accession>
    <name>A0A9Q0L9A7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_02411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Thiol protease which is required for parasite excystation and invasion of the proximal small intestine of the human host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9A7"/>
    <dbReference type="OMA" id="YFDEAGC"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000096">
        <property type="entry name" value="Cathepsin B-like cysteine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040298676" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="12">
        <location>
            <begin position="68"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5068478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="292" mass="32219" checksum="CB5FDBE90E39AEC6" modified="2023-09-13" version="1">MKLFILVLLFAIAFTSIVDEINNANVGWTAQEYEQFAGKTKEELRSLLNTHLGPYDLPKKEFISYEALPTNFDPRDKWPSCIHAIRDQGNCGSCWAFGAAEALTDRFCIQKNIDVILSTQDLVSCDKNNYGCDGGYLDVAWAFMKATGVVTEECYPYTSGTSGQTGSCKRTCKDGSTGKKYHASNYYSVSGITNIMNELYTNGPTEGAFEVYEDFMNYKSGVYRHISGSYLGGHAIKVMGWGVESGKDYWLCANSWGTSWGISGYFKILKGVDECGIEDDIVAGMAGTVGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9K6</accession>
    <name>A0A9Q0L9K6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein nirf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9K6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040288738" evidence="1">
        <location>
            <begin position="21"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="686" mass="78453" checksum="4A69A589BA9C8EBA" modified="2023-09-13" version="1">MKFNLLFVLSLVCCTLLVQSQITEMNSLNFTIGMDYVNAIFIDEDAGLLYFLDQRNNGDDYIWTYDRYTLDILNYTNIGVYYYPYRGIDTQNKLLYLTNYYGQFIKFDLTTMEVVSQCYLSHGIPHKVELDLVNQKAYIGDYYPYVTKVDLSSFTQESVLTLVNYFTGSVIDVDNGILYAATDSSSQNNATLHKIDLSTFTEVNSILVNSSGIARLKYGVIDSGNQMMYFGTDQYSMNIVKINLTDFTLVDSTTISSTGGCYGAGIDTTNGLAYFFSQYGNLMKLNLTSFTSTGSTYFHDAYYVPIVFDSSASNAYLGLDYADVMQINLPALTVGNRSDSIVYTEVEFLWVDEINQILYLYFGNVGGIIVKIDITSFSLVDYLVLGLYEEIDYGAIDSENGFIYIFLSTGDLDIAKIRLSNFTLDGIVTLETNLYVDMGVFDTENQILYLVIWNSTDYEEYLVKMSCPNLEIIQSFILSSDASFDDILLDSSRGYLYMLIYDYYESEYFINQYQASTFNQVGQTNLTEYNIGDWALDKTHQFIYFFDWDNYATCRINLNNMQVVDCLDITMDDCYSFFITSGDSYLFMVIDFYNSTSDEYEGALVQIQTSSNQLVSFTPFDYELFYDYESCYDPTTNYGYLIDYYSTPVTLYQLSFPPPIPNPSSSQQTLFSFFILGIMMMILGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9Z7</accession>
    <name>A0A9Q0L9Z7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein piccolo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9Z7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="394"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="853" mass="99289" checksum="728E7901360A5AB3" modified="2023-09-13" version="1">MSFSFKNNQTFPQSFLIRSLKQIPYKGIAWVKWSYGNQSNQTEKSSLLGKGSVKWDKKDSINILISNDGKKSHFYPKQLDFFINLIPDSNPNTIITSAISFPVSEFAHIQKSKKAQIPLKFNQSFNTNQAFLEIIFFPILNNSHKHSFSANLKSKSNLKSNSNLNSDSDSDSDSDSELNHKKTNSTDNKNFKFKEEEWENNMIKSTEQLMKNLFEKKAKQQNEKENENENENENENENENKNEKENEKEKQNLKQNPNKNIASKLEKKLTLLQYQSSLNSIIDLERKLITSGLYFTDAKYENGFPISSCLILKALVYWDGLGSEKKKIVDVVVNSFRNLIEGCQQDISQMSWVLSNLCFMINLIRSYHFQSIIERKKQNYLHNQKISRKPDFFSNVSNFQEQLLGLANVIVSNMCRLIKTQASQSSKYMLDENQQETTKEFSSSHPIGFMRGLLNILYDNFIPEILITAIFSHAIDSLSQSLINLLLNTKGLCSFSIGIHLKIVISQILDWLQKLKIPYSKTEFNHMKQLVDVLLMIKNVADDSENDFSVCSEIGSSLSLEEIYQILINFTVDLHDPVPIPEEKIHQFKIFMEKNSQQNIKEKSIPSEIQINYHHFNYPVNGWDEIEVPLSVKTIPELSFLNQNIQVLIQKQKEEEKKIQLGKIPHLNENENQNQLKNQNQNQIKNQNQNQLKNQNQNQLEDSEKEEYSDEFGNESSDSEKEKKLKNQTKKSNQNSANSHQKISNTIENDSLQINKNKSQKNYNINDEKFAKTTQSFNQNNFNQSQSNEEKIEKGNKERKINKNRTKKKEQKKKQKEEKLKREKQKKPTKRRAFFSCMMKTQPDEKSKMKNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAH5</accession>
    <name>A0A9Q0LAH5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAH5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="482" mass="56789" checksum="738A2989A0604A14" modified="2023-09-13" version="1">MKKFKPQITIDGYPFSKNRHNSTNTTGWYRCRKRCGMTAKLFYDPDLQCTTNGQHKPTCQRISQSREVADLWNLVEELALDNIFTPDRVYREMCVRIDSDLEKAYITPSHQEVKNYVKNIRLPSGKKKKKKISRISNHQTLSKTDFLRVEQMSPFNIYIWASSSMIYNLSLAEQIFIDGTFKVAPKGFKQMIVVMAKLPKLNLFYPVLYGLTETKSYQNYLIFFAQLLGLIPYLNPDYITIDFELNLKKSLDRIFPNSKIIGCYFHYCQCLNRKFQELGLNEPIHKKLKRKLQKLPFVPQENILDKVKKLKKKFPNQERVFRYFRTTFMSDLRSQMWNYSELPKEIKRTNGCVERYNRRLNDIFPTPRTNLESFSAHLAQEEKYWQTRLSTTISRDGNFDFSSENSNSNSNSNSNSNSLFLNHPYLDPDFEIDEDFEFDEDFEFLSDSDSDSDSDSDSDSDSDYTNSQISKQQFAKENEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAM8</accession>
    <name>A0A9Q0LAM8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAM8"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="250"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="612"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="707"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1057" mass="125140" checksum="671AE47947C1C68D" modified="2023-09-13" version="1">MIKLEDKLFNNQLDANQSETIKEILEKDDKPNPKRFIELIEENISIVLNQFNRRNMKNIYTFRLLSQFWNSLKVFIKPILGWKISNYKTNKKKLTKSILKSWFLSISRFILFPLLSENKSIFDNFYTFLPKLQFKNENENIIPISIQSRRQMDNFFSGFGLFIKKYSKDSPLFDKHEKKAETNLSSIKSIFSDTFNSEEEIEKIFLFLSALNPKEIDKELIEEHKKGKSKYVLTFDNVSKMLFLQFRNFVNLPTIISGETGCGKTALIEYLFETILGQKIKTLNVNNSIKKKDIQNLIEEGEKCFPKPFIILFDELNTAPKSFIPIFKYLFIDKMFNEKKISTNIRLIAAINPYRERSGTDKKEYERFGLFYQKDDENEESKKIQKSVYRVQKLPDSLQKQILNFNSLQKEQELPYIQKMVKNTFDSIFKKEEDIKRIRGFMENFIEYIQKSHQYIREEEENQNQNQNEKKNLASKVSLRDISRTLRIFRWIYESRSRAGIILLKDKIDLKQINLKQIKEQKEKEEDGIIIQKAIYLSLFVCYEVREKNQKKRKKYSIKIFGNEKSKDYKEIIENAKTNLIENLDYNFKEKMIAKNKALKENCLLLYISIYTQIPLFIIGKPGTSKSISLEVILKSFKPPFEINELLRKLKLRSLYQSFIQCSQIRTNKEIEEVFKLAKQNTKNGNTLGVVVLDEIALAEWSSEFPLKTLHSKLEESEKELSRRLQKRFKQNKNENENEKLEDILKEMEAVSVVSISNWILDPSEMNRGILIYRDSITEIEKTAQQILSSKNTGMNSKIPELFADSLSRIYKNIIKNQKEKEKNSEWKPYFGLRDFYYFVKMIGYSYITHNISYNNESLISNALLRNFNSKPEIIQNISQFQNESKSLNLISLTKITTKELIYQNIQKRIFENYGLNNPNEISDFSRNMMILIDETLNLPIILQIIESLIEEEGRKISVVFGNSFPKDQTKVKIIKDLHKKETIFMHKISMGHIENLIKIDPNFRLISICDKSHAYHNETPAILNRFEKYLLKLDEFIEFGIIRRFYEQQKEMIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAY3</accession>
    <name>A0A9Q0LAY3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAY3"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="293"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="562"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="777" mass="91524" checksum="B8F599B53524C0B5" modified="2023-09-13" version="1">MNFILSKNSIQKKNFFDTWFWGSNILREVVKNQPEDITTPIHLDFPQKNQYKNRYKNENENENENENENENENEKQIKPISSIQILNLYIYKNEKANQYFNGIETFFASGLSSSNITKYFINSNVEVILTIEGNVFAKGYDIDRNHPQEFINISSSIEDINDRIIEDFVCGMNSIYLLTSNQNAYGFGSNYYGQLGFDSKKSQRTEKPILMMKNVSKIYSGNHTHSVFLLNSNQELFGCGDNYYHQLGSDTKKEREINKITKIQNIPKGKIIDLHLTCCHSVMLVEDEENGKRKLYSCGFTERCGLGADTNTQGHTTEFTEIKSSLFENDEISEVDCGNFHTLILTQNRNLISFGSNRYGQLGIGNTEMIIRKPTLITLPDVKFKDDISNYHICCGQTASFFYYSPSPFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNENEIEKLKEIISKKSIKESNQIFEMIYSNRIINLALYLEIKEIINSNEKIEETMKRIYLNENKNENEKENEKENENENENENENENQNQNENQNQNENQNQKENENENEKDFVIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFEIFEYWIYSNQIKDEIQITKEIINELEIGIDYFQLNQTNPNLLDLLIKKFYNQNQNQNQNQNQNQNQNQNQNLNQNQNQNQNLNQNQNLNQNQNLNQNQNQNLNQNQNQNQNLNQNLNLNQNQNQNLNQNQKQKQNLNLNLNLNLNQNQNQNQKKNKQKFCIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBE9</accession>
    <name>A0A9Q0LBE9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-oxo-dgdp phosphatase nudt18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBE9"/>
    <dbReference type="OrthoDB" id="10005910at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044716">
        <property type="term" value="F:8-oxo-GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769:SF56">
        <property type="entry name" value="8-OXO-DGDP PHOSPHATASE NUDT18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769">
        <property type="entry name" value="MUTT/NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="157" mass="18413" checksum="EF925760A000175D" modified="2023-09-13" version="1">MSVHKSVFIAFNIIVENNKLLMIQESKRECYKSWYVPAGKIEVGETILEGAIREAKEESGLIIEPEEIFHVEHIPRSHIEWIGFCVTGKVIGGKLKTKKEKDEHSIKAEWVDLDKIKEKKLRATDFLHYLDILLKKRKKEEKEEKEKEKEKLNTNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBJ0</accession>
    <name>A0A9Q0LBJ0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_11494</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBJ0"/>
    <dbReference type="OrthoDB" id="10266268at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000203">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0736">Signalosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="14">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5069832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="206" mass="23461" checksum="3A506C55E48A785E" modified="2023-09-13" version="1">MAGRLENAIGWYHSHPGYGCWMSGVDVSTQLLQQQFNEPWLAIVVDPKRTISSGKVEIGAFRTYPQNYKPPETKESEYQTIPMDKIEDFGVHANTYYSLSISYFKSSQDKKVLDLLWNQYWLNTLSSSPLIRNKDFVSGQVSDLSIKLENAEQKMHSGGGMHRRKKEESQLSKISKDATKSATQQLNGLISQVIKHNLFNILNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCM0</accession>
    <name>A0A9Q0LCM0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein 4b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_11111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCM0"/>
    <dbReference type="OMA" id="IRRHEEW"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="154"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5070263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="431" mass="48811" checksum="8121EA64F9FDFF05" modified="2023-09-13" version="1">MSNFLEKGISIINSAVAKDKEEKYDEALKNYQLGLEYFLLALKYEKNEKTIQIIRTKMEEYFQRAEKIKALLVELEKKKAKPEKLGESSNSKEKDKEDSENSKFREIMKSAILSEKPNIHWDDVAGLDHAKESLKEAVILPMKFPRLFTGKRKPWTGILLYGPPGTGKSYIAKAVATESSSVFLTVSSSDLVSKWVGESEKLVRELFRTARENKPSIIFIDEIDSLCSARNDNESESARRIKTEFLVQLEGVGNSMEGILLLAATNIPWNLDPAIRRRFQKRIYIPLPDEGARAKMFQIHLGKTPHSLTKKQIKFLAKKTEGYSGSDISVIVRDALMQPVRKVLSATHFKKVSGEDPDDPKKVRDDLLTPCSPGDEGAMKMTWEKVNNEDLFVPVIGVEDFMKSLTLIRPSVTTKDIDQQLKFTQDFGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDR2</accession>
    <name>A0A9Q0LDR2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDR2"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="299"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="490" mass="58190" checksum="466632839F06F825" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFQNQNQNENYFDFEIICEQNKTSFKTHKSILSSRSQYFKSLFNSKMKEYQENKLVLKDVSSSILSSILNYFYSGKIEINLENAIQILIFSSKYLIDELIEISSKFIKNNFQFETVVDILKLSERMSLNQLLDSSYKFILENFDEFIKTSHFFELEENHLNSILLNDKIPINEFELFQSIIKWGKYKSNINQIKHNKKLKKKEKEKLKNQISNIIEKIRFIDFSKKELTDTLKEYAIPNQISQKLIQFQKLQNQKNETELNQFTEKEDSLIFKSRKRFKFQSSILTQEKKYFKKLREWINDDSFFYKMKIGYSAKRDGFDCYKWHEICDDKGKTLIIIKTKDNYIFGGFTQIGFTTDKSQWNERFRNFPYGSIIDSKAFIFSLRNDKNDRKPEKFSIQKGEEKNSLYYRLEYGPTFGANSSSDLWLDSHLKSGMSNIGVNYNIPKGITYNANEAKGYLAGYGNWKVDELECFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEB4</accession>
    <name>A0A9Q0LEB4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein yellow-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEB4"/>
    <dbReference type="OMA" id="MWILDNG"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040303131" evidence="5">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="468" mass="53143" checksum="AC08598DCE3C446B" modified="2023-09-13" version="1">MQFKLIFVFSLLIFIPNSFSNPVIGQKTLVYAWNYVNYTFQTQEETDEYFNNKYYENVFVAGVKVDSFGRYFVTTPRWKEGIPATLGIVITDAEDNLYIQPYPSWEMNKLGDPNALQSVLGFEIDNQDRIWILDQGKCNGSAAINGSIKLLIYDLKTDNLIQKYVFSESEASLSNSFLNDIVVDVVDGFGYISDSGLPLVEGDELDGGILVYDFNKNTAKRVLNHQTCTQNSSLWISINGEHVYHDQPMETGADGIALSPDRTVLVFCPLTSRTNYRINTEYLKNWKLNDNELVQHVVSMPKLSASDGLAFGNNSVLFVTGLETSSIYSYDNPIQNPSKFEILTSDTQSMLWPDTIGFDHQGNIVVVSNQLHKFLMNELVFNLTNPMDFINFRIWKIYADCDSYLFYSSPQPSSTSSSSSSNTVRNVFIALTAVFAVGFIFLLINQFRLHRKYKPRRMFSPETNSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEB6</accession>
    <name>A0A9Q0LEB6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEB6"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="630"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="440"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="923" mass="108679" checksum="4E1ECC211621484F" modified="2023-09-13" version="1">MEQFISNEFYWSRIYGTGEQPPKLFRSAFIEWHDQFFVFGGLSEENSNETYCFDLKYNKWKKLEIESKPESRRGHTGVVYQDKWYIFGGNKMSRAFQNLDIFDFQKLTWKIYHPSTEILPPARTYHSAVIYNNYMYIYGGLTYPYKVIGDMWRMHLPTQKWEKVIQYGKKLFEKSAAHTAVVYGDNMFVWGGDCDTGEYSGEMNIFHFPTNTWKVLNPMGTVPISRESHTAVLLGSKMIIFGGQNEYKGTNFNDVCEYNILTNKWDIIKYNTNLVPSMRDDHCATLCNNGNEMIIFGGTSSLNENLFSDCWRFTFNSSLVQDMKNYYLNQELCDIVIIPGYISAHSSILKYRLFGISEYPNQDNNINNHFFIKNNFSNFISVCKSYSKRAVHILMIFIYSGLFEPDSLETLNHLSVLSKNLFIPELFELCKIMIQTDKNLETDEIEMKTQDLNLNEIQNQNEIQNQNQNQNQNQIQNQNEIQNEIQNQNQNEIQNQNEIQNQNEIQNEIQNEIQNQNEIQNQIQNQNEIQNQNEIQNEIQIQNEIQNEIQNEIQNEIQNEIQIQNEIQNQNEIQNQNKNQNEIQNQNEIQNEIQNQNENQNENEIQNQKKPLSNFQKNFEYMYQMRKEDFDFNIIIDHNNETIKIPVHKDILAARSQLFFGMFSLNIKDSSGCAPDFSGRSPETIEALIEYFYTGKIIQNSITPSISLELFDAHEYYNIKSSEIQKYVIQIALENPESIISWENVFEILQISIEYDIRVIIEECLIFITKNSTNTLLEQLDIIIQEVGNVPYIEEIFGQILPFSKFWELILLLNTYELISKHRLVVNKFIQNLIVENLEVIDLNQNLIFRNYLLHFLYRKKTIRDSINFKIIEVSQHNSEWKKFNEDLEMKLKTKIKKEDIVMAIGISDSSDSSDSSDFSDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LED0</accession>
    <name>A0A9Q0LED0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LED0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="265"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="482"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="605" mass="70604" checksum="ED2D3838CB3C52A1" modified="2023-09-13" version="1">MNEIIFFGSNNSPKLIKNEQNLITKPIQFKFENENENEKQIKQIKQISSSNFSTIFLFKNGKAIEYLNENDSNQNPEKIQIKNIQKVTVGYQNEAILTKEGNVFFLKRYEFENPQEFINISSLIEDINDRIIEDIVSGYNSVYLLTSNRNVYTNEPAKFPEISAPAFEIFPKEEKPILIMKNVSKIFSGDSSNFAFFLNSNQELFGYGDNYHGQLGLGESRNGTVFINPTKIQNIPKGKVIDIQCGNMHSVMLIENENEDENPKRKLYSCGNYQYNGLGHNENTYEFTEIKSSLFDNDNILDISVGNEHNLILTEKGKLIGFGDNYYAQLGNGDTKNQSIPIQIELPKLRFNENISNYHICCGQASSFIYYSPFSNLEEDLIKLFQRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLKEIISNKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFEIFEYWIYSNQIKDGIQITQEIIDEIQRGIDYFQLNQTNPNLFDLLINKFNKIQQKVGMKEEKKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEI3</accession>
    <name>A0A9Q0LEI3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEI3"/>
    <dbReference type="OMA" id="DDTIPFI"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="196" mass="21960" checksum="C604FA53E1BD509D" modified="2023-09-13" version="1">MAESKVKIVVVGGGSVGKSCVSLRFLQGKFVSEYDPTIEENYRKMMIIDGIPTMLEVIDTAGQDEYHGVRDKYLRTGEGFLVVYSITSRPSFVEMQSILEAIQFARNSKTIPAVIVGNKIDLLSERQIDKSEASEFASKHHIPFFEASAKTGENIVACFQEVIQVAQKYKQQEEDSTTNDNSTPTIKKKRRLCILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF79</accession>
    <name>A0A9Q0LF79_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase smg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10065496at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031559">
        <property type="entry name" value="SMG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15785">
        <property type="entry name" value="SMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="1930"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3457"/>
            <end position="3489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2087"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="604"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2099"/>
            <end position="2118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3489" mass="406055" checksum="DF825C11C1D8C8FE" modified="2023-09-13" version="1">MNFVFYNAQIKAENYEYKTDLVFKSTEISFGRRTISFHSIKRYYFSSFQNLSIQLNNNKVFSFIPSSHKYNFDWEFQNFFKTSWRNRNNSQKSKMRFKRKSKSPVSNFQSLENRLSELFQQSLSLEIKPENRIDLLQKILEYFEDSENLSQLETQHQEISKAFSLLIQQNDPSFYLKVLEIIPDIICKFELSLNSFLGIILTQMKEENFGYFQNYLQIIQEILKKVEELDSINTNNLNQLAEVLTQTFSRESTQETIIQVIEIVAEICRKNKTSLSEQLFVPFSHFLSLWSTEKIDLPEDSIIDINQMIRDTFQGLWSRNTKLTDQNLYDLVEAIEREESKLDLKEILTFFEGILVNLEIQEFDTHFSNIKHGISACFFAQDISSLEAKETMKEFVWRFMEILPERFLKRFFLDGFKYRVLEDIHLAKNHEIITERMGINLAILRKTRGFLDAEDLKEFWGKDIFSMVFSRENKDLYQVAFATYQELVSFAQKRDVQDAGFEWMCFFAQENKNCEEEIVTLLMIVLGCFKLAPNNLGNGNHYMTKLFWIFTYIVQIVPNTNFESLKVQLVVIEILSFLVRNGRFFQMESLMDDFCGINSQLDLFGNLNENLNQNENLNQNENENLNQNENENLNQNLNLNQNGNQNGNLIGNENHLLNLNQQSQIIRTIFQRLGKQSCSWNFNLQIKKIELLHFISQEIGKDNDKKGLCRAIDTEIVFEDIGYFLVDLDIKIRAYMLYVLNICMKNVSLSCFRKYQQLIVFEILLVRLQEREEINKTLLEMKKEPDQYSLFVACEKTQTEEDEECEMDPIPQLIAAFGTGSILNLETIRPKDNWRREFLLAKESGAKRKETGQSFSQDHLHQILVFVLKNETKMSVIQNFLYRIYYQWQGNNTGIENRQGNKHIGNAILRSCTEEVLAWAVTRAARFCVDSRLKTRLGKPKELLNLLSSKLLSIAGEIVNAGIRNVRQDADTSGYSDMAVIRLTQLVCDLEKYMVNVYNGSLSLPTPDEKSVEFFIKHKAVCRRWILNNIRALMSIARSQQRHTSAILFTMNYIKHELFPKSPKSARLVLERAAVFLCESALALGDPDTIRGYLHFVRKQKQIEPKRFVFLDYTISWIEGILHFAEHQIEATLRVLNSRVISALLEKQKTDLPKSLVEIVSLSFGFVADHLALAYKMDEDWAGLKNLFADIRTIISRFAISPEPTFLHEEQVVDFILSSEETYPRKTPVAFSQKMLESLNNHKQMFRATRNRSYLLQRTSNFFDVVSSFVIADMMESTIPVEINRNRQKTDHLSVATDMLCQDIRNLSDEGLSQLQPYAQKLALVQFARDIKRTNTHLISFPISEIVYLKPDVLGTFHFLVELARSRRNQKNTVYSNQDIQENEARNSRILTKISDIALRKRVVQARKSGSFSHAELLIKRFEKFRSEPDIPDWVFFEKAKLELAQSHFNRAEEAMVRCLDILSHFDRQQAESLEVQDSIYSAVSIATKIKREKLRGKEILSEHDIDDIENLYLFGLESCQASSRMWKKYSDWCFLLTSMLGLENNESDSRKFNFNSKKYNSNNFDNPNNFDNFNNFNNSNNSNNFNNSNNFNNFNNSNNFNNSKMLKFSQSAIQALFKFLQLSAHKHTEYSTMAVIRIFVYLKKFSNKFNTLFRKLIATTPAKPWVMILPQLFARMNDISQNSENLRRVLTDLLVRMGEEFPHKILLPTIVWRLNANQKAIQDSYEEVVHKLMKKGEETSKTVAGVTRFVQEMKRISQLVDEKWAQLVSQFKINSALSQWLSRALTINGTNGGINLLFNQLKSQSAESQPIHKYQRFMEPYLNKFQELVENTIRNQTNLTPHEKKFIDAFGESLLEAFEDMRSPQDAENFDESWTRIRTIGAQLENILKRNEISTETISPWLSGLQSDEIQIPKLRSNEKLQTIKLAKVGPRVGVLFTKTRPKRLVFQDTTGKYHHYLLKANEDTRLDERIIHFLTIFNELLLMHTKRRQKRYQFFLRSEADSKNSKNAKHLHTLQQAVRRQKTTQNMRARVYSVIPLSTQSGLIEWVEDGVPLLELYRQANDRKSSLGLEISSPNEKYHKYLEEEMQKQQQSVDANEEPKKNADIDINEKSKENEKKKKTVETFNPKKYPLEILKRLFERLQSETPDEIIGNELLCSSISSEDWWKRARTYSRSVSLMSMVGHVIGLGDRHLSNILFDQRLGEVVHIDYNVCFDKGQQLKVPERVPFRITKIVREGLDPTGLFGCFKVQCVNALKILRANSEVLLQILDPFLCDPLREWVVDSRDRMFKLHMFLNFAITKLWEKTDQIHRTNTSFSFKETLLSDELEIAENAHSQCVSCENEIMSLLREEEPPLAEKSFQKHNILPYSRELVHIFHSMFHLSEAMHENLLRIEEREMQIAQDSQMYQQLLPQIQELESAYSILAQRMAQLESDIHAHDSERRKIVAEIHNQLGIYREKNKQFSQMMRIFQSPSMLRPLVQSIETQLQNIQQMGNTELQLLSVLMALAESNPSQNGIDFAKIQLWILQFENENRKVEQDDSAQVLIDKLQKAATIAEICGVYEERANAVNHDHLIALRRCSESLEKYQKVVLTMGPNYADLSKISIWTKNMETMLQTPLGLLHKTIEQEVLPNCQSESEEQKMRQYSQFTNRINNLVFEHEQRQTQLAIIDEQRRELEMETQKQSRKLSDTIEQYLAHLQKDTPGPDSDLQIGPLTRLRTNRFEILLRSTAFVIHSIGDQMMRELSTLPDENQWEKLNSSLSQVFGKCKMCLELLSTSSQQHTEELLSETRFLTATESYEAILRNMAASFLNQMQSTTLPEILRYLEIAQKKDPTDSTRSVYPVLSVPDTQTITALAQLYVSITHNVQMPDHYLSDFASILGAQTHDANNTILVRLLSIFELFISQVISVYQVLPLDYKNLFYSHEKHLQVSKIKAICGIIPHIFETIGTLESPQIIHECIRAYIHPFLIEFALSILLPAISKSLEDIVQYAHSRLKSSPLSDTQMQTVTNTYQHYLDAKYQLSHTASYLAVLEQGANEIHTELSAINSQFVQFQWIADINQIRDPTTMEIAFCNSRHRFQILSEINDALDQLKKTHWRVQAVSSIIHEIRDIILSQLSKIPQTKSNRQNSPEQIIRQKIWESLSLLAPSTQSSNTPTDLLTQILSNLCSQVLYFEDTMRNDNIDSENSVVVHKLLMFLQSVYPAWSEYFSVAKQSDAILHQIEIQKSQLQILTQNIPQNQRLIVQLKSDLAKQVSVCSKLQTNTHKYFQIQRVLWDESDSYLQNMIKPSIRANYVPLGLAVTILLNVKSAFFIQFNHFLELLGKDLEQTSRILADHTGEEFSKSSLQRKNQLSDIRTSFVDLMAKWTQIRMATSNALFYSFDTNHKIESGKIESIIPKERQQLTQKELQYLRNLDYLSEPIRLYEQKVASNAARFQETEDFANRAIANVKRKLTDNESVEDQVDRLISVATNIDNLSQMFYGWNAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFB8</accession>
    <name>A0A9Q0LFB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFB8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="435" mass="50350" checksum="AE2A3149A76D3C90" modified="2023-09-13" version="1">METSDPFSYSEKKAQISSLFLHLMGIKPSDDTNPQYVQFVATLHYLIFLGEIKAPCKVQMGSIWVDSFLCINPDFFELKFSDNSLVAPQKYDYDPEYTLKRTNYKQLALVTGEEVNLSFESDLKASLVLELFNVYSSAESISKNITSARYLRPQYALQMGDMIPLTILAHWCHKNSIFTKNIQVLKKEERPLVVHVQLDKAGLIITQPPFEPDPPIPYTASYEILFSTKRPRFKLIVEEEEYEFILQNDPARDFLFHLLTFKFNIQNSKAFHQFFSEEKGNFVLSLDSLFTRPPVLPKTSIAKIHYYMKKIIAAKKYRVPVLVTSQRIYGNLLLLPTEIQLVFGSEKEIVAHYKNTLIFQNDIDPTVLLLETYANSETQKFIIQPKRAQDTDVLMNAFMYFKTLSNDPEFIFEKEMIKIFASVLGKINRIESLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFU3</accession>
    <name>A0A9Q0LFU3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adp-ribosylation factor arf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFU3"/>
    <dbReference type="OMA" id="HFLCHRN"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003539">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="186" mass="20775" checksum="CC6B642156F22ECF" modified="2023-09-13" version="1">MGKSISKALSKLFGKKEARLVMVGLDAAGKTTLLYKLKLGEVATTNPTIGFNIETLKYKNINFTVWDVGGQESIRPLWRHYYKGVQAVIFVLDSSERESKRISDAHDELHRMLAEDELADAGLLVFANKQDLDGAMTQEEVIQFMGLNSIKNHKWNVQLASAVSGQGLYEGLDWLSACVKKKKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG28</accession>
    <name>A0A9Q0LG28_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG28"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59056" checksum="B599A27D239F46A6" modified="2023-09-13" version="1">MQSNNFYQFLDAINQRVSRDGLVNLFFSLKSSSSQQEIESMQYIIDNLPFSYPSVSVDQFIIQTATERCTQSMYQMPPPDFQQSQQSQQSNFGNQNFGNQNFGNQNFTNQNFGINLPHPEDPPYIPPPPTTSTFVDSNFDRPPEPYSFTTTSTVPTTNNNLFSAISNTDHNNFVNQDPPKTRDHSNDQCFKTCSTLIAISWLGVILLIALIAGPSIEQQYLWKVHIGCDITYTSTTKTAIYTDDEGVVISATIKDRCKPKYSSQGITETDSSCWISPRDNKKAKVLPDFKFSSTKAATAFMVLNPFFFNLPLVIYVLVNHIDERRFWIVLAPFFLVIFPIFAAVLMFKKSSKKYMWPLAIWMIIVDIIFIAGLMGPAISESNRLEQTTCYFFNRVEAISCPGCDYILDYSSCQNAFNEVYDSYHSKESYYVKLVPDDKTSLIGSVYFPWVIYDFENERPSNNTHGNTCWSEKDYSSSSGKAPESTTKLLKDKGMYKGGAAGLGVVTAISCLLLFIRYMIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG55</accession>
    <name>A0A9Q0LG55_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG55"/>
    <dbReference type="OrthoDB" id="15111at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="157"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="200"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="205"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="287"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="373"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="378"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="535" mass="61771" checksum="D93FDFD8DE81648E" modified="2023-09-13" version="1">MKQYPNNQKIQENGCFILQKFARENEDNRNKLRNLKGIKCVIKAMNNFQNNQDIQKYGCGALWIIAANNNENRIEIRNLKGIEPIIKSMNNFPNNQDIQKQGCGALWNIAVNDGIEPIIKAMNNFQNNQDIQKQGCGALWSIAYNDKENKIEIRNLKGIEPIIKAMNNFQNNQDIQETRMWSFRNIAVNDENKIEIRNLKGIEPIIKSMNNFQNNQDIQYQGCGALWIIAVNDENRIEIRNLKGIEHIIKAMNNFQNNQDIQYKGCRALWVISFNDNENKIEIRNLKGIEPIIKAMNNFQNNQDIQENGCGALGDIANNNENKIEIRKLKGIEPIIKAMNNFQNNQDIQYKGCRALWNIAVNNENKIEIRNLKGIEPIIKAMNNFPNNQDIQYKGCGALWNIAVNNENKIEIRNLKGIEPIIKAMNNFQNNQDIQYKGCGALWNIAVNNENKIEIRNLKGIEPIIKAMNNFPNNQNIQKKGCRALWNIAVNNNENQIEIRNFNGIESIKKAMNNFPNNQKIQEKGKWALEKLQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG72</accession>
    <name>A0A9Q0LG72_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G1 to s phase transition 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG72"/>
    <dbReference type="OMA" id="PAMGAYN"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="467" mass="53301" checksum="7510B74385808E81" modified="2023-09-13" version="1">MNFIYLEDETSDQEKNQTQIKKQISIALIGQNGSGKSSIAGQILIQTGKINQKVLKLFQQFSGNNQNQHFSWITDNSNEERISNSSQEITKFHLETKNKQIILFDIPGKKYFIPEMINTISQIDLGLLVVSSIKEEFEEGFPKGQTVEHLLIAKSLGISQFVVLINKIDLLVEPEYLKIIVSSLSNFMQKIGLDLEKQVFFLPISARTGMNISKNQNQNQNQNQNQNQNQNQNQNQNQIQIENLIENLNCKDQSLLDIIDNYIKQEKFIENQFRMLVLDKYQKTMKEIYLFGKVLSGKISKKKQIMIFPKKFKCEIKDIKIQESSVKECKSGDQVKIILDPESFEYIDAGCVLCDSQSSVSIPKQLLCQITICGTTGIFAKGFKCILHSLSSFSECEVTEIISSVNHKKMKKKNPLFLKEGESGVVKISLFQEICIEPFSIFEPLSKILLRDRGVTVAYGLVRKIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHC3</accession>
    <name>A0A9Q0LHC3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inter-alpha-trypsin inhibitor heavy chain h3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHC3"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="58"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="420" mass="48071" checksum="DC502B96740684A0" modified="2023-09-13" version="1">MFKKTNRKLEEEKLMAVQPFCAITENLETKEKEYYLSLMMKSKYDGEGIKKFGRPLINCVIVLDISGSMSMSFTGEWKTNENISSKLEVAKRTIIGLTEHLKEDDYLGIVIFDDDAEVLIPFQKFGEIDTEKFKKAMNKLDTRGGTNLEEGFIEGSRMIENHLKKFKGDEMKEYENRILYLTDAHPTTGETRSDGLFSLTKKSAEKKIYTTFIGIGVDFNTELIDIITKTKGAIYYSVNSSSEFKRRMDTEFDYIMTPICFDIEVKVEGAKIQSIYGSPDSETKKDTTVAEISTAMPSDVNENGEAQGAVLLLKMDKSVADGIPLNIVVTYKDKYGNDFKEVNNVIFPELNQNQNEFFEDKSIRKAILLIRLVDLVKKFHKVNDKEKGQKFLEYLKTEISIINDEKLNREIDLLNDLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHG5</accession>
    <name>A0A9Q0LHG5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHG5"/>
    <dbReference type="OrthoDB" id="43452at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="249"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="365"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="535" mass="62307" checksum="75D5336DAFC8FD3A" modified="2023-09-13" version="1">MRSELYRGMFLSVTEDKSNKVTDYSELSNESFQILEYWIYSNQIKDEIQITNEIINEIKIGIDYFQLNQTNPNLFDLLINKFNNQNHNNKEEKKEKKEKYFSTIFLFKNGKAIEYLSENDSYQKPEKIQIEENIQKVSVGKQNEAILTIEGNVFAKGRYINSKRFINISSLIKNKKDRIIEDIVSGSDSIYLLTSNQNVYGIVSNEYGELGFDSQTLFKAEKPVLMMKNVSKIFSGNNSRHVFLLNSNQELFGCGYNEQGQLGLGESRKEEKIYKLTQIQSIPNGKIIDIKCALYHSIMLIENENENPKRKLYSCGYSQFNGLGKNDGDTYKFTEIKSSLFENDDDDILEISVGFSHTLILTRKGKLIGFGYNEYGQLGTGDMKIQSIPIQIELPKLRFNENISNYNIYCGSFKSFLYSFSFFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEETMKRIYLNENENEKDFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LII2</accession>
    <name>A0A9Q0LII2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LII2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="91" mass="10974" checksum="EBE4BD31573D9EA0" modified="2023-09-13" version="1">MDSWKSVRNLPKPYDSYLKINFISLFIYQIPMLILFIQELLIYLKLNQKIFIEWITVSIPSIITLGGILIFGIILEVDYIKRNYFLPKYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIW1</accession>
    <name>A0A9Q0LIW1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIW1"/>
    <dbReference type="OMA" id="CLFHQHG"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="46"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="295"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="425" mass="48399" checksum="CF0495775850C25D" modified="2023-09-13" version="1">MDSPSWVELSMASDLDSKNLSDSESPQKPPEKEPDPLLIAKKKKMIAMMVLVGLFFGLELFTGIFTNSMALMADAFHMLSDFLSLIIGYYMAKISIKECSTKMTYGWKRAGIVGGLVNSTFLLALCFSIVIESINRFIEEPEVKYPVFLLIVASSGILVNILGLFIFHGHGHDHGHSHGHDHGHSHGHSHGHSHEHKHEHKKEHKHEHEHEHNDKETEGKKSKEDFNLHALFLHVLGDFLASIAAIVNSLIIWKGNFKGKYYFDPAISIVIVIIIFKHTYPTLKQSLKILMQASPENANIEKITKKIQDINGVLMIHNFHLWQLSEKVIVATLHVVLDSNSDYHQIAQDIKSIFHSHDIHTTTIQPEFYHQFPGRKRNKSCDLDGQCLYTCKLDECRDRRQINFSFPVLKDMAKSDDIETDDQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIZ3</accession>
    <name>A0A9Q0LIZ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIZ3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="278"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="465" mass="54883" checksum="E6140871F330035C" modified="2023-09-13" version="1">MDNNNNNNQIQNANENENENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLNSNEIEIKYSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIENKEKEIEEKWKKEVEDKNKEIEDKNKEIEDKNKEIEDKNKEIENKEKENQQMKIEIEEKWKKENFPQFSDSEIIKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFSGENWQKAVDDKGKTLVIIKTKDNFIFGGFTQVGWTMNTSKWSYNGGSWGRMKDENAFIFSLRNDKGDRNPAKFTIQKGKEDLAIQSQTVCGPYFGSNSPDFYLCSNLQPGYSNFGSRYNLPNGITFESNEAYSYLAGSHDKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJM5</accession>
    <name>A0A9Q0LJM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJM5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="129" mass="15136" checksum="189488EAE6B52DD5" modified="2023-09-13" version="1">MKSKKKSNQKSLKKPNQKSLKKSNQKSLMKSKTPNPKKRQKKILTSQTKKPKTNKKTQNHKLTPLPKSQNLTQTPTFSKKIISPISVKHFPQNFYKKLRSLDTTDENFTPNFSKRFEMQLDQESDQEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJT7</accession>
    <name>A0A9Q0LJT7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJT7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="352" mass="39886" checksum="FE0BFBDBA41387DD" modified="2023-09-13" version="1">MSTSGELKLTTEKVLVFKNGDCLIIKKGVGTSRNNTYWTEDVPQNTILGSVWVDPKDGKLISFDAGVQTTKEKSKERVLCTDFFQLLDSNKGSKCTVLLPKDKVISGTIREALVNNIDEEKTDKPVQTSGLPDLSRSYRSEAIKGNLFVISNDQGDHIVRIDQVQQLILPQNSKLYTKKIITKTTKRLTFRFEPKEEDKQEKDQKNNENSEKDQKKTTTDSELSIDEKEKSDKQDEKKGELITRELIIVYFVVGVIRWIPTYRIQVAPKSEQMEITEDKKTPKQILDLSCQAEIINAGESLVDAYLELVVGVPSFKFRDTISPFSLEPTIKNLLNEKIPQIMGVSRAPNQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK35</accession>
    <name>A0A9Q0LK35_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK35"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="166"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="451"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="600" mass="70196" checksum="1833572343DD80F5" modified="2023-09-13" version="1">MNDCLFFGQNKFPSLIKNEPDKITNPIKFEFENENENENKNEKQIKQISTVTVGSQNEAILTKEGNVFAKGKDINPNNPNEFINISSLIEDTNDRIIQDIVSGMYSIYLLTSNQNVYGIGSNKYGQLGLDSYTLYKPEKPILIMKNFSKIFSGNSSLHFFLLNSNQELFGCGDNDYGQLGLGESRRETRIYKLTKIQNIPKGKIIDIQCGSTHSVMLIQNQNKNKKRKLYSCGFYSTNGFWKDEYTYEFTEIKSSLFENDDNILEISVGHFHTLILTSNSKLIGFGSNHFGELGTGDKKREQIPIQIELPKLRFNEDISNYHISCGYNKSFLYYSLSFSNLEEDLIKLFKRKEFCDISFKTKNGEIIEAHKLILKYRLNQNENQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVKDYSELSNESFQIFEYWIYSNQIKNGIQITQEIIDELETGIDYFQLNQTNPNLFDLLINKFKIKLKLKTKSKLKSKIKKIKIKIKIKIKIKIKIKIKIKINKKIIQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKC5</accession>
    <name>A0A9Q0LKC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Camp receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKC5"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="308" mass="35457" checksum="15FEB78C7CAF4363" modified="2023-09-13" version="1">MIHNKESIPCIIGSTFGMTGSLIFILVYLFLKEIQDTSKKFIFTLAIFDFFLGVSAILPGPSNHDLCKIQGFLVTWTFLTSCCIICLISVFFYIQSCTSKKMNPQKTDMFFNAGISGIIFLSLIISMISVFYGKVGEGNSHWCWVTKHGIETLTYIIVWITLPATLIIYIIMLIKIKKTRENSKTFHYKMFILGCIYFVTQLPTLIKRGREIVNPSVSDSPFLDITQALFVPTLGLWDAVFFVFLDKEIFDLLKYHFERKKYFSVNKSDSKQKDVNNKDKEEDEDDDDDDDDDDDDDEVIQSLIRDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKL3</accession>
    <name>A0A9Q0LKL3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKL3"/>
    <dbReference type="OrthoDB" id="159630at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="521"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="614" mass="71137" checksum="25B28D5D825D6A2E" modified="2023-09-13" version="1">MFQKILDQEEKKVLDLLSNIGNIGKTEKEREQLMIYESKKYGRYKVIEKLISEKISVNCFDYLSKTPLHYISSNHNNTKIIEMLIREGAKVDALDKSHKTPLHYACQNHNSKEVIFLLVDLGSSVNLTDSNGMNSLHYECCSQFSRMEVIKYLINKGVDINSKDHFSRTSLNYLLLERTKPEIIKEFCNLGQIDFQSKDHLGQSFLHYVCYYPNQADLDKLFRLFVESYSVDPNSQDFDLKSPLHLLILNSSSLPLIEYAVSKGADVNSLTNDNKTPLHVAFERGSSFALFEFLLQKGAKIHHKPKKSSSALALAMINKMEINVIRLLLQHSENPNCKIYEKSQVKTPLEISIEKSDVDLFKLLLHYGAKTKLDQIKDLSPEFQNWAKVYSSLMEDFLNLFSRQELTDFEVKCKNGKSIGFHKLFFRLRTSDSIDLFLDENNPFHSKIISNFQGFALASSQEDVELFLKFVYSGICLPSKEKEVKEMSKKIGLAKNWFRKKDHRRGLLFDLEKLYQHEESKDFAIIVFGKEIKVHKIVLLARSELFRGMFLSVTEDQSNKVNDYSERSFEAMKELIYFLYFDSLSKDCSFEVSEELKDAVDFYQLNLNSNLNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKZ1</accession>
    <name>A0A9Q0LKZ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="665356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
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        <location>
            <begin position="374"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="851"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="885"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="919"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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            <end position="986"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1055"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1157"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1225"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1259"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1499"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1420"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1592" mass="182579" checksum="4879981210107DF1" modified="2023-09-13" version="1">MNIFEIISNKEISKLKEIKNISEKEIKEKIKIIKFSFQKKVSKEIIEILISKGIPINLKDIKGRNLLHIAIKNKSEIEIIEYLISKGIDIKEKTNQNETALHFACQSNSIQVIEYLISKGIDINEKTSYGQTALHFACQSNSIQVIEHLISKGIDIKEKTYQNETVLHFACQSNSIEVIEYLISKGIDIKSKTRQKQNILHFACQSNSIQFYIMHVRKNSIQVIKYLISKGININAKTNQNENVLHYSCQKNSIEVIEYLISKEADIKAKTNQNETVLHFICQNKNNSIEMIKYLVEKGIDINEKTNQNQTALHYACQNNSIEVIEYLISKGADLNAKTDQNETILHFACQKNSIEVIKYFIEKGINIKSKTKQNETVLHYACHFRSSLEIIKLLVEKGVDINAKTNYNQTVIHFIFQHRNISSLEVVEYLVSKGIDIKTKTDQNETVLHTACQNNSPFEIIKYLISKGIDINAKTSYGQTALYYVCQKNSKEVIEYLISKGADINFKTDQNETILHSACQNNKSLEAIEYLIEKGIDINAKTNQNQTVLHSACQNNKSLEIIKYLVEKGVDINTKTNYGQTALHFACQYNPSIEIIEYLISKGADINSKSNQNQTVLHLACQYNTSLEIIEYLISKGIDINSKTNQNETPLHLACQYNSSLELIEYLISKGVDINSKTNYDQTVLHYICQSNPSIDIIKYLISKGVDINAKTNQSQTALHFACQSNSSFEVIEYLISKGIDIHAKTNQNETPLHFACQSNPSIEIVDYLISKGIDVNSKTNYGQTPLHFACQSNPSLQILELLISEGADINAKTNYNQSALHFACQSSPSIEVIEYLISKGADINSKTDQNETPLHYICRNNPSLEIIKYLISKGADINAKTNQNQTILHFACNYNPSIQIIEYFVEKGIDINARTNQNQTALHLVCQYNPSIPIIEYLISKGIDINARTDQNQTALHYICQNNPSLDIIQYLVEKGADINAKTNQNQTILHYVCQYNPSLEIVEYLIEKGVDIDEKTNQNETALHFACQYNPSIEIIELLISKGIDINAKTTYGQTALYYACNYNSSIEIIKYLISKGADINAKTDQNQTILHILSQYHPSLETIEYLISKGIDINAKTNQNQTVLHYVCQNNPSIEMIEYLVEKGADINIKTNQNETILHYSCRNNPSLEVIKYLISKGIDINEKTTYGQTPLHYSCQYNSPLEIFEYLISNGADINIKTDQNETVLHFACQSNSSISIIKLLISKGIDINAKTNQNETALHFACRSNSSFEIIKLLISKGIDINAKSNQNETALSISIKNSNEKTIQILLQNEVDIYDLQENEIKKEFIDSFIQIYSLNHDLNNLLNSKDNFSDFTIKSIDGFKFKIHKLILLTRFDNNNSILQKFIDNCYHKTKEEIKFIINFIYTGFPDFENIIEILNQQMNKNLKENENQNRNRYFWGREFEEEKRILKEIEENENKIKEFFKEIGIEIENKKRRKGIINDLSKLYQQNETKDFKIIISEEKEIKVHKLILFTRSELFKGMFLSVSDSSNQVHDYSRKSNESIQQLIYFLYHDKFKENEFNSKIIEEVEELKDFYQLNKNSKFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL12</accession>
    <name>A0A9Q0LL12_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL12"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="482"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="583" mass="68029" checksum="E3EBB17DEE0E9860" modified="2023-09-13" version="1">MNEILFFGRNEMPKLIKNKPDKIKKLIQFKFQNENEKQIKQISSGYFSTIFLFENGKAIEYLNRYTNQKPEKIQIEENIQKVTVGSSNEAILTIEGNVFAKGSDINPKNLYQFINISSLIEDTNDKIIQDIVSGRESVYLLTSNQNAYGIGDNQFGQLGLDSQTLRKTEKPILMMKNVSKIFSGNSSYSVFLLNSNQELFACGDNFNGKFGLGESMNETIQKLTKIQNIPKGKIIDIQCGYYFSIMLIENENENPKRKLYSCGYYLYNGLGQNGNTYEFTEIKSSLFENDNILDFSVGNAHTLILTSNSKLIGFGDNYYAQLTTKNTEPQLNPIQIELPELRFNENISNYHVLCRNEKSLLYYSPFLSSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQVEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKENKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELNNKSFQIFEYWIYSNQIKDEIEITQEIIDELKIGIDYFQLNQTNPNLFDLLIKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL42</accession>
    <name>A0A9Q0LL42_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho/rac/cdc gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL42"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF24">
        <property type="entry name" value="RHO-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="179"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="396"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="549" mass="63795" checksum="81AF47DDFC98474B" modified="2023-09-13" version="1">MAVTLWVKVVFPYEQTTKIFGTSPIKTVKELKEMVCEAEQITNSFEYGLYCTSGNGFWMNENQTLISYEIWRQESIEFKKKRIKKVNINYGAETKLIEMNEEEAVSKQIKHIIKEFGLTENYTEFDLFVSENLLDRTKTLLELEIKNIGAAIFKLKRKTGLIFQRSGEMNVGLKPIFGYYLDNAIQRGKREVPVVIEKICSFIEVKGIDIYGIYGKTGVLSKIEDLKELFDKSDDIQIEEITKSPHDVASLLKLYLNELPEPLIPWKFYDSFISSDEIQEIWLKMKKFRTIVSSIPKSNYKTLLLICQHLNKVSKHSQQNNMNSKNLSIVFGSLLLKDPRDSKSSLIRRSTVSLLTKSHNDLDNNQSRNLLHIYSCCQALIDEYEYIFGMIEKNFSEKEYAVAIYDFEGTHEEDLSLIQGDYVEIITKFETNDETESNENEQEKGGWWKVKSLKTKEIGLVPYNYIEIVKDYVPQAEANENNSYRKALTEMDSLKIMLAENIELRTQIQTKKENLLKRIAEFKENLQVKIDQRRGVELIVKKIFGENAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLD0</accession>
    <name>A0A9Q0LLD0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-protein coupled receptor 19-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLD0"/>
    <dbReference type="OrthoDB" id="10624484at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="173" mass="19422" checksum="323F3AB9409CCEDD" modified="2023-09-13" version="1">MIFVKNILQDKISVIFHCINFVSFVIAMAGLGSLDSTFTKYFVLYFFASIFAVGISIGMIILRALDKFKQVGRDLVNYSIIIVLSWNLLGANDVYSSLCISLGSQCKKSTKAYVLGVCLHFFSLVSLFLVNLYNQKLPSQGFEILESNITDQKETKRSTDPSVPYQLPTDQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM49</accession>
    <name>A0A9Q0LM49_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">U1 small nuclear ribonucleoprotein a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_07318</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM49"/>
    <dbReference type="OMA" id="LKKGWVM"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="239" mass="28135" checksum="18532943803735E9" modified="2023-09-13" version="1">MQKDSNQNDDQKETPKQQEHQQKTLYIRNINEKIKLRDLKKQLETLFSKYGTILKIIAYRSLRMKGQAFVIFEDINSAISAKEKLQGYNLQGKSIQIQFSRSKSDIIAEKEGNLAEHLERRKRKKEERKRKEQAKKREKQTEKVAKPRIIQTSRMPTQTTQVQQPNRILYLENLPKQMTVKMLDLLFQRFPGYVSSQLVPGNRAFVEFQHEIGSIEARNNLQGYQLSEGYFLNISFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM68</accession>
    <name>A0A9Q0LM68_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="1914"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="2357"/>
            <end position="2517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1299"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2027"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2700"/>
            <end position="2723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3094"/>
            <end position="3152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2415"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2027"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2700"/>
            <end position="2711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3099"/>
            <end position="3119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3120"/>
            <end position="3130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3131"/>
            <end position="3152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3152" mass="372145" checksum="E99AC8F31B1E7AA1" modified="2023-09-13" version="1">MNKQSLIQRVKNKKKDKNKNKNKENKNKENKNKKEDIDTNIDTNMNTNIDMNMNMNTDTNANTDTDTDTDTDTNTNIQTQQEQKEIQIYLYIPLDRQPEKEKEKVLAIFYKTNPKQNEQMIKVKNKPIWEANLKGEKIQNEFQFVIISKKILRDRKDNTSSQFSSKPFSENSKELLFFKPSDSIMQLDIEYFGDLIKRSILQDSKTVAFFEYESNNISNNFEKIEESPKFIFLDIAFSFDTNKLDVQDMLKDFKNVIQEIDLDSKVVSKYLQSNENFMKETNKHKVLKLIFLNKFELITKILNPLLLNNFKAIYDDLMNQELFKILAEVFSQLKNPSIEKHIVVLYISLLNEHNIPIPEIDSSTQVEDSFKKIFEFFLKERISKHIDDKKALEIFVKSYIHIVLKKNNIPFLGKLDQIVPLDKLPFNVLVDIILAAIEQFIHDITIAQYIEFWKPIFPLLEQYEKEKNQEYIQQITELADKNFKKIKTIAFVIDYIQTIIIEKVSLPSWFSETFKKRLITEYSLLLKEKKVKKYHLEKLEFEIHQKCWNNVAEEIQGINITYNNNISAESLIQKFEQLHSNIYNVNRDINKVNLWVYLVKLNQQLISEKGKELCEKYELFSKLDTEHKCIKEIKENIENGKIKVCELEKVTEDFFKFVIIKLFRDEELVYDPLIEKFKKQKEILQKFKEQQKIIQKFIDEFTGNKVTNPNLKEKIQASPQTEILEALVFFGIEENIIKRIDIYNSISESNWIKELVWKEVTKDQDTIQVKSSIDNMDKKIKIIERGFIEQKFTFKDLNEYVTSKMNDSDIKKEVKFLNKVITRKLESSILKKYKLIQDFEPKSKLFIFFCGKFDIETKTDFEEFKQIYQKMEEKTLEEVPKLCEIQQKYVEGFKNSFFEFISDIFPILEQKNNDSLSILMINCSISSAKIQRLGSRLENLIAIKKFQNFNKFIEEALKNENEWRKKFIQEAENWRSQKDIINQIFTSLDYIIKFIEQKLETPKQRAYKNLVNIISKKKTQKKIFIFSIKDSIEFECKLFMRESKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKNVVKEMSFNFPNFHEINMLLLENENQENEDENENENENGMESEDESDDDNEDKNGDQRKDKKRKKRRYLRIFEEFFPLIQDMMSILNHFKVSLHPDFIKDYSLNIEISNPNDLDKERNKIASQKSHWEEIEKETEEKYFYAYFYSHHQLKILYNVLKKNKNNQNQQNTEQSGKHKTKRNPEETKSVEQLLKLTNTKPFDWTQKKDLKKDFKAFIRKLHQNIEKSIQEKEKEKEKEKEKEKEKIKEKKKIKENRLRSLFFKNWAPQGQEPIFIIQIKKELEVYQFITILYLKYTKEFPSREQVLFCHKNTTEDDISRFVIIFKKLNAQNKHQIFSIVFPHKLPKKLEMVLISKLKTTTSTNSMNKNKSIMLFSLENSEATKNYLSNFLISLGQKEIEDQFGFEEFSDKEMFIKEELKKEHLGRFKNMEAFFSEFAGCGKTFQIRKKLFEKNSCIANEKSQYKYCHIDIRVDDPHRLIKKLIKQDNKYKHRKKCFHFDIAYCAGNETAELIWSLLIFGCIEDKRSWNADTSAFIFNEKRHLIYFEVPSTRVKNSFFGLKYFPALNFIESTHCEINSSTVCKNYYEIDDNQIISVHKNKNMMACANFFKKKDQDFEEFNFKDRNKILLDENYNEESLFEKSTNIDTIKNEELTFMLISNFWKLLGFYINSIKDWKEFYSETTEYFLDQRRISEKFQKKISDLIVDTSSKIIQRSFSWTKTIAHRSDCNNFKQFVLWDHKMNGSIFAFSKSQDNSSQFGFFSRNRLPNNFFDNRIKAALKSRNVLSGPISTSHSKNIEEYLGFLLRFGNSNSRYEIIPNIRETTYQLTNDNFLKCILIQIRLFSGLPVVILGETGCGKTRLIKFLFTDLLGKNLHVLDIHGGTTEKEIKDKMDGVIKNMKKGVDEIILFDEFNTATKECISLMKQMLFDRIYKGKTIAKEIQYIVIANPYRKYETKPKEDVNEKIDTKHKSKSKKDSNEKTKSKEDSNKKTKSKEDSNKKTKSKEDSNEKTKSKKDSNEKTKSKEDSNKKTGPNKQDLEDLNSGFELSVMFDYKEKTKEMKKLLRAIYRVREIPDSFFDHIFDFGSLDKKIEELYLRQMIKNKFSDIWGFSPQENNDLIELYKTLLFKSHEFAKEYSLDGKSSISLRDATRALKVWEFLLGTDLTLEFFANKSDAAEVEDSDFGQKKLKMIISIILSIFISYGCRFSVDLRKEYYQYILKKLEIPQFLEKSKPKFPRDYSDFESIIKQIRENFSNKIDADENFKSKAIAPNEALTENLLIEFICIQTKIPLFIIGKPGTSKSLSIETLKSWLSNSSLNAQIRNGKLQPIRVFPLQCSPQTTSQAISSIFQQARNYQRDLKNYERRLREKEEETQQTLFFRRIIPVILLDEVALAEISPDFPLKVLHKELEICDQSEQNEDLIPVIAISNWRLDASKTNRGIILQRNDPDKDGLIQTGKRIQDFIFLSSSDSKDRKGMDLSGSLKNYLEETPKKLAKIYLKILKKQKQKQYIEKQMIRDNFFGLRDYYYLVKMTGYNLKDKIKSNQNQNQISGIEDITSEISSKEFRQIVFKSLCRNFGGVPEFFNEAVKKLFMDHYPNNLNDNNKNIKNDDKIPSPIDLVLDNLNSERNQVNAEETSPDNLNSEKKNVGAKKNSPIKSRHVMIICEEMAILPLIIEKLKSDLNGKETDNSGKKKDIIKLLYGSYFAEDKETQTFRDLKNVASFLAENNVTVLCNQDQLFEPLYDVLNQKYTKIGNKYISNISFGPTTTRVTINSASRIVVVMPKSVVYKDLSPAVLNRFEKHLVTSGDFLNEIGQQNLANIQTHFEEIQNITTLSINELLVGYHPDLIPSLALKLQKRLKKNIKKGINFQKFWIKIANLGSMIYLRKLLNTNNDSKDEQKKNGIRETVSNYFQNYPPNLKQFLNNLENSRKNFKTNRVILLTNSPPFDLERFLEYEEFKEKCSSVSVSNFGKTDDFMNYIALHSKNKQFLFIQFEVSPNNRVMESFQFIKSKIESGEIFKVKRKRNENNENNENNENNENNENNENNENNENKKTKEKQKQKQKQKQKQKQKQKQKHKKRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMV7</accession>
    <name>A0A9Q0LMV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Atp synthase coupling factor b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMV7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="815" mass="94451" checksum="7664B173D5750E01" modified="2023-09-13" version="1">MSFKFNKQIQPNFPKSENYKSLQETLEKKSKLIYQKFEYEKLTKPKYKELILRIDSLFQPEKEKENNNKKSNKKSKHLQVAIQRFLHRITNFVLIPFIQNNLMEEWFNIQIKEVSGYFDDERKYSHKIPNFLSLLNTSSCYPKLWNSNLIEAAVNFLEDISTEIINFGSFDFANKKKLEEFQYKLSKILIGKKEEKEKQSKIPSLEEISRKIIENTSFVLENDLTESLPINIIEDIFDDMNLNGTITSSNISNFKQIEVLDFKGNFWINNDIISKIIHFDNVFELNLTGCLGLSDESLKIICGNEMIRKNLEVLILGVWSGKPILKHENDCKVCLSNYISTYIQEPSIYLRISEDALVNLKYLRNLIYLDISGCFGKNNPNSEYFQDQNAGEIYQEEVFQEFLPQLNQLQTLILGNDGVTTSIVEMIPSSIINLKIRISGAPRIIDKDHSQNLVPVYYENRKESGVKMVSAFEKLVNLKILSISEMKLSIYSRRSFDKPDENGYLLDDKFALLLKKWNQLAYLKIEPFDDLVHLEMTRDWIPNFSERLLTLDLSGNKWIADDTLLEVEKESKGLSRLALLRSLDLSCTFVSDESLCKILPNLFQLDYLNIQSTRAGNETIKFINQYLQNLEVLKLGGGNYSNQITNITNEGIYELFLNQNIQKLFLLSFPNITTLTECNCSKSYKENECIFSLPLWKNVQELHLNEMRIGGLFKHLESTNDQTFLQSLIHFDCQATVECDIYEGNHFFLDKVYSVYLENISLRIVDPSRYQVSGICLKKLKNLKSFIASENGGNGGFSPLSFCSCPNHIPSLRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNA2</accession>
    <name>A0A9Q0LNA2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-10-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNA2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="619" mass="70946" checksum="6420B2391CEA3EAC" modified="2023-09-13" version="1">MEFLLKFVVPLNEGYAINEAIMRSNLSGRVLTDYLMKMINQKGFSFQTFEEREIIEDIKKKACYVSLDFQEELKNSKETDYQLKDGKIIKLGNERFKCVEALFEPSELFQSYLPPDIFGSFFVSGAPIHQKIYNSIMKCEENLRKELFGNIVLSQRANTVWIGGSILASLPKFRELLISKEEYKKTGAKIVHERCFFFEDLNFKKIFFIFYFESELNIFQNSMNQLKDNQKIVIDNGSGMIKAGIAGEDAPRVAFPSIIGKPTGMVFGRNQKSFYIGDEAQSKMESLKIEYPIQNGVMKNWDDMEKIWNHIFENELKVDPKNNDILITEVPSNARYNREKTAQIMFEKFNVPNFYSCNLAILALYEAGKTTGFVLDIGDQSTSFVPFYGGFPIERGIVRMEFGGRDLTEYLMKMLNEKGYPFVSSGVQKEMVREMKEKMCYVALDFEKELEKSSLKKSYKLDNGKVVILQEERVKTAEALFQPDLIFGMGMQPPPITSPFAMMRFNGEGIHKFAFNSIMKCEEKLRNDLFGNIVLSGGSTMFPGIAERIEKEIVQLAPSKTVVNIIAPPERKYSVWIGGSILASLSSFKNMMISKKEYEESGFSIIHKKCSLQDPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNW6</accession>
    <name>A0A9Q0LNW6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_06913</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNW6"/>
    <dbReference type="OMA" id="CQNILHW"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05573">
        <property type="entry name" value="STKc_ROCK_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000570">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="89"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="381"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5076051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="465" mass="54508" checksum="8D2F6BB394046F4F" modified="2023-09-13" version="1">MQRKSEQSNNQKNDTKTNKVEHAKGYIENFFKDLNDSTKQRMIRIGEFDSQIQKEKLSKKEQKKLRNAFLQLENKYNRMRIKKLTVKDFQLIKVIGKGAFGLVCLVREKDTNEIFAMKMLNKKTMIEQGQAVHVKTERDFLATANVPWVVALYYSFQDENNLYLIMEYVPGGDMMTLLINKNILSEELTRFFVAETVLAVEAMHKLAYIHRDLKPDNLLIDASGHIKLTDFGLSKELKNIDNTMDTLKTKKDEYSILETDKFRSQIELRNASVKARRQLVFSTVGTPDYIAPEVFSKTGYNDSCDWWSLGVIMFEMLCGYPPFSAKSRRETFLKIQNWKKYLVFPSDVLVSREAKDLIYKLCCEPENRLTPEQIKKHPFFKGVDWENIRQQTSPYIPQLSSAIDTSHFDSFEDQIDLLLNDSQKANDDKLDIVQFKGYTYKRLEKKKPEQFIQDWIKNFKDLEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNZ2</accession>
    <name>A0A9Q0LNZ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNZ2"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="349" mass="40140" checksum="2B854191EDF28ACF" modified="2023-09-13" version="1">MNEIIFFGLNQYPIIFKNESNKIIKPIQFKFENENENENEKQIKQISTGYFGTIFLFKNGKAIEYSNENDSNQNPEKIQIENIQKVTAGEQNEAILTLEGNVFAKGNKINSNNSYKFINISSLIEDPNDRIIQDIVSGNGSIYLLTSNQNAYGIGLNQYGQLGFDSKIIYQTQKPILMMKNVSKIFSGNTSFHVFLLSSNQELFGCGWNEYNQLGLGESIKETKIQKLTKIQNIPKGKIIDIQRFGTGDTNDQLIPIQIELPKLRFNENISNYHISCGYQNSFLYYSPPSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP44</accession>
    <name>A0A9Q0LP44_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP44"/>
    <dbReference type="OrthoDB" id="114080at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027951">
        <property type="entry name" value="Nepro_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14780">
        <property type="entry name" value="NEPRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolus and neural progenitor protein-like N-terminal" evidence="2">
        <location>
            <begin position="69"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="429" mass="51466" checksum="2B4B091FFD1762D8" modified="2023-09-13" version="1">MNSNDLQFYSILNSIESKFNWEFIQNNSQYLFQPQILSFHPKKLLKRKDFHIFYIFLKELFFEFKEKTNQKINELEGNFQLIKKLIYTKKNQHKKTKHLQKLTEVKKTLQRLFELNISEFAVKIQKIFQENEVIRKNTNLQTPDLYIVKLFRIKLLSGALLMKNLLESIIDSFQRFEILIRQTHFMAFSLVCVSVLSQIHQQIKTLQMDFVDSFYLLGEASKCLNYQLQSNQNLKNKKKSSSFQEFFLFKQQFMQIIEMPLERFLGTEFQRKESFAIEKIAQLNMEIPSVYNHVFSTENEDLGEFEMRKEESIMKKEDSIKQEKTIEKWNISTNNENQNQNQNQNQNQNQNQNQNQNQNQNQNKNSFSFSINIQQPQNQIINSLPQQIEIDEQISKKRKKSKNKRFENLVKLQQPQKQKNEIDDIFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP57</accession>
    <name>A0A9Q0LP57_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP57"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="277" mass="33077" checksum="5875ED98F49DDB71" modified="2023-09-13" version="1">MISKLIKEKDLFSWFSKIVKKNVNEEIEDKKFENYLKIVLQKIIIEKEVLEKSENPFIFFKTICKEKGIPKNFFDLEKKEEILLILQELCEESKYQKRLCKPFSLAVDFINPDLEIISAGTILLRDNKIVIDTHLEIFTFDLKQKHTIKFHNQNPSIIKISFQKDCFNILFESKKEKSKFLNELENRIKIEEKQLKQQAHFKKIVECCQKESKKKKKNKIKKMKKRKKATNKSNGWLCGLHSLNKEEKLEKKKFEVSFQVKILDDNFRPIQDARLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP65</accession>
    <name>A0A9Q0LP65_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP65"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="139" mass="16413" checksum="2C585F659C045338" modified="2023-09-13" version="1">MSTSQITTRSKSKRKIETYKLDKPTQSILLPTESKRILLIWLFYNIQNPYPTKREKQQLCEKANMNLEQVNNFFINARRRILRPIVEAIQEEEKKKDSPTTHQMRLKSGKKIPVSEIDFEHSPTLNSKNNYDNFESGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQK8</accession>
    <name>A0A9Q0LQK8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ada2a-containing complex component 3 isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQK8"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="304"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="406" mass="47526" checksum="8A81E3E286B1C48E" modified="2023-09-13" version="1">MSKLFDAIEEGNFRKIKRILKGGVDPNFPEHNTALHLASKFSNNYKLFKLLLSYGANANSQNLDTPLHYLCTFQPNRIDLIRLFLKFGGCVNARNMNTPLHYVCMSKTTLEVVKFLVSSGALVNAQNKFTIFIVNRKNIHLFHLCVYNSSKKEIIRYLISQGARIDARNGKTPSHFAFDENIKDLLKFYNSIQEDFKKLFKRSELCDLVLKIENKQIQVHSMIFQFRIPEIPYQKIVGILEKKKLEEAMNFLKFVYYGRVKNLEKLKSMIYQDLGLGENYIEKKEGKQGLVSDLKMLYLNEKGQDFKILVGKEIIKTHKLILFARSRLFRGMFLSVKDDSNSVHDYTQKPSKSIQQFFKFLYFDEIPNNIQIRIAKDLLEMADFYQINKKSYLFLQLEEILQNKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR27</accession>
    <name>A0A9Q0LR27_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR27"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="191" mass="22538" checksum="3919F26AC3C93C53" modified="2023-09-13" version="1">MQTKKTRNNRWKNNFMKRKGNKKKQKYGGRGRGQIGGYKNQRIKGYWKEEEVKTPINAPRNTNQFIIDRHGEDLVDETRQIEEFSIDHFGTMEGLVNAQGKSHVSLRSSFPNSFSSSPFFIQNPNIELDLPKDDMAIDFPNDDPDFSSRYHRILQNEIKKLRSEKKILQEKYEETTKEMIKLKKELQNNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR72</accession>
    <name>A0A9Q0LR72_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the copine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR72"/>
    <dbReference type="OMA" id="MVHETEF"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="513" mass="58136" checksum="E9B54F09FEDFE33E" modified="2023-09-13" version="1">MQAQVPMSGFKIMLTIKCQNLLKKDKLSDSDPMGVLFAKDANTHELTEIGRTEVIKNNLSPKFTTTFELIYLFEVIQIYRVTIYDIDNESEKLEKHDVIGSIDFNLGELMASPGQTLHRRLEYAKLPARQNGMCSVIAEAMSNTNTKVIFDCCAHKVDKKDTFGKSDPFLTISRLKEMEWIPVHQTEYIKNTLDPVWKKFKVSLDILCGGDLNRKLKFEVYDWDKSGKPDFIGEFETTAQGILDMEFLNLNILNFHRKYSFIEYLSGGLEISFIVAVDFTASNGDFTKKNSLHYRQANRYNDYQAAIFTVGSILAQYDSDGLFPAFGFGARINEQITHCFPLNQNAKNPDCVGIQGILKAYNDIFDTPKFSLWAPTNFAPIINKTCEIAKEVKKDQQKYYILLILTDGAITDMEYTTRALIEASKLPISIVIVGIGPADFGKMDILDGDDSTLKIDGKKAQRDIVQFVPFRDFKTKGMDKLAKATLAEIPKQVVQYFSKQKIPPNSPRNPLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRH1</accession>
    <name>A0A9Q0LRH1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Upf0394 inner membrane protein YeeE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_05857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRH1"/>
    <dbReference type="OMA" id="YSICNES"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="365" mass="40638" checksum="F763D168A484357A" modified="2023-09-13" version="1">MQQSILLPPTPNLAKQLKQYPLTVKLAAVIYAGFAFGLGVSKGYLFHPHAFVASFHFKSFLFMKVFLSALATAAFVKGVISLIPGARERFRYARGYCFDLPNQKLLVYVGSFIFGIGVYLTGSCPGATLSQVGSRVSSAIPAILGGLLASIVVGLLKPSFNNYKPKQVFDMKTDTLDVKFHIPFHYFAFAMSTLMFFMVFLIEFFFSTIKDLHQFDATISMDYHGIWGMLKNEVWPPWIAGILIGTAEIPVILIALDEMGAATGYNVFIVRILDKIWPEYFKKHPYFSGALGGFESYWQVPYLFAVAVGAFLSRVTSDSFFPIQGLHPFIAFIGGFISIFGAKTCVEVVLQEMDLVEQLLYQSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRJ4</accession>
    <name>A0A9Q0LRJ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thap domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRJ4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="242" mass="28821" checksum="EF1954F2D52E96BD" modified="2023-09-13" version="1">MNLQPIISRMLKKIDDLDEKMQKNLHLPQFNQVYGIVKSSIQPFFQKSQEKFISKKNVLLIVLIHLRKYYIFEDMVSFFGISLSSLHKIIQENMKRMENALIKWQIYCICKICKKRKTSPISDKGISPKEKCCCSQSEEDRSHNYTMLVPNLEVEFEVNFIPRPRTEKKWFSENEASRDAGITFFSPNYVEFHNQILLSITNRLQEMEIREDKFARKLVIHFKIDPYSKRNNEIDQNNNKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS57</accession>
    <name>A0A9Q0LS57_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 12 cation cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS57"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="99"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="9">
        <location>
            <begin position="571"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1197" mass="137185" checksum="60C90A63F8B97F74" modified="2023-09-13" version="1">MNSKKEKIQVQSIKKYPKKVNFSQQNSTTNYQINTESINRIPSILGENDLLPSHLFYEEKGVNRPSIAHLKQNEKPLEQNSQIPSNDERINHNIGMGAGVIARSILSLIGVIYFLRLGFIVGYAGIGFAILIIILSTLVTIITTLSLSAISSNGRISAGGPYHVISRSLGHAFGGAIGIVISLSFVISVALYAMGLAETMVETLGLRMSSSFYVERLLWGWIFMSVMFLGIINGLSVVIKIQVFLLVILIISILFILSSSFGRNYSKEIFCENWKPSFTHNQDFFSIFSLFFPAVIGILPPSNISGDLKTPQKALPKGLLTAVLITSTLYLLTTLMLGAIVPRSGDLGLKHNYFIFKEISFWKPIAYVGLFAAAYSSSLSSFLSGPNIFQAVCEDRLFPKAINFFGKISGSKKLPYRAIVLSYFLSFLAILLGEINRIASYTTAFFLLAFSLINWACFQASIAHLPSFRPAFKYYNPYLALFGTILSIALIFLINWISALVSLVAVLILYKYLDLRKLDVNWAANRDGRQYLKVLNSLIRFGNVKEHAKTFRPGYLYLSTSTPTSSRNFSLINFFSESLKEGKGMFMFGEILMAQELEEEMNRSKWIEQRNGFIHWAHSHSVKIFYDILIANSFQKGAKNLLLLTGIGNFRPNIVVLDFLENWNQEEEFTNKNNTNEETNTEFITENNLSIIENEKEFNNNLERIDIFNTINNEETNTEFITENNLSIIENEKEFNNQNNTNEKEFITENNLSIDNEKEFNNQNNTNEKEFITENNLSIDNEKEFNDQNNTNEKEFITENNLSIDNEKEFNNQNNTNEETNTEFITENNLSIIENEKEFNNQNNTNEKEFITENNLSIDNEKEFNDDDLQRIDIFDTIFGENEKEFNNHLERIDIFDTIFGENEKEFITENDLSIIENEKEFNNQNNNNNIERININSTISGENETEFITENDLSIIDKSDLENQEIPLENSKLKFIYSGKKWEIPNIFEEPKKKQIPISEYIQIISLSFDLSYGVVITKGIEGIDLEKKYTGNIDIWWLSDDGGLTILIPYLLSKNKNWRKSKLRVFSHTHPEKMGEDEDDTYSQIKNLLEQFRIDAEVIVTKEVFEKPSSKYLQDWENYSVSSGEKQNQTLKLIKLSEVIQKNSRKSDFVVISMPFPDKSMNPKLFMSWLDFLSKGMPPLMFIRGNHKNVLTFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSA3</accession>
    <name>A0A9Q0LSA3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myotubularin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSA3"/>
    <dbReference type="OMA" id="ASAPECN"/>
    <dbReference type="OrthoDB" id="2408718at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039802">
        <property type="entry name" value="MTMR14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524:SF2">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="408" mass="48278" checksum="713EE82BA1F387C0" modified="2023-09-13" version="1">MELIQITEKDLIHLFETFGKMSENKKTTENYEKVMQNCINLWSIDNEFITIENDKEDQLCATYPSRILIPLGKNLPDESRKQAKKLDKEKIRNLIETSRFARCRKRFPIPFLYYNNKFFCRSSTVSTDQLMNEEQKKNNLLEKAINADVELLEMFGVKSVLNFMLEKSRQKGSDYSGGSELTAPKKPYHHFHLIATPYPGVKFFINYKLNKSDAKGIHYKWENSRNDAELMIPEPIKKLPSLIPISFDEYQKWEINLLSKNYLKMMLATLICDDFKGGFLFHCLSGWDRTPQFVCLCRASLWADGVIHKSLSPEQFLYFVVGYDWFLFNHQLAYRMEIHAEIFSYCFYFMQFIENDELSIFTLDPSIKRVDQNQRKEKLVALREKFFELYHPVVDPLINFQKDVSKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSY6</accession>
    <name>A0A9Q0LSY6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1416" mass="167941" checksum="9AAB5CC02183D534" modified="2023-09-13" version="1">MINQDSSFEWITMNKIIPNSISQNEINENSLENLIIIVNKICSKFGVEEEFLIDTQKIQSVEKNTHFVKIINKIREISRNKKLDFRKLKPNSLSNSQQTSENTEKQEKQENSSINQISKSDFQKIFTYTQFDEQGNAKNIQTLEYSFAKLSDCILKSEILHESNISHKIHLQSKIYEALLVKQQKLPIKILFSRNHTFNKKKGIIFISNKGFTMNIKSKKGKNQVKEFSYEKDTHFFLSQTKLNEVFITINSKNAFLIEMKNPRQRDILVNLYLLFSRSEIIQKLIQTHNEKINENDLLFVKSSTHSDLPTITKALNQQSYLRKGVSTDQKYTSKYDYDKEQNNSQENLSFLPLSFNYKMECTSSDSCSFYPKIIDSFGEQIEPKIQIVLDSDHFEIVFSTEFILKRRYSVYSHIESCFPGDTNIRFQFDEFYYNKRKHASPFLKQWFSHKKHNKIAKCSIQTNEGKIKPCSIIISPDIFSIIIDLPPQEPNSKKQSQKSTKRIYNFQYLRSMKFKVHSKNEQYLFVKLSHDFFIILIFASKIQVDEIREILKQNQTNFRLFSSCQNTFISRIRKTSNKFAATLTQDGSNIGKQTIILNEDFLLVLNNNGIFSRYYLFNREELENEYTDSKIKIKFSNMGIQTEIQFTFLNWKTKHQFIRALKIFDSKYNAHQMMENYPHIMKNEDFFPVQITLQYQTTSVKGILKINPLQRTISILLSQENRERDFFISQINPLIEFNRNIEIYFTHDNEKIFLQFDSEFERRLFLKKFHKLKKHFSSSNPIHQLQNANLNDIVDFTIQLKLPQNFKNNLNYFLFQQIPDPYLPIKLFQIHPFDPEKIAVLDTILHVILVGSIIGILDSDTQHKRIIELNKNFVLNSNFSDQNPSFLELLNSGQTHYFAFSDSQEKQMFIKILQNVQKKLQFDNFEVLFVSQNQIILPMNLKLEPTYIHYQFHRQQRKIIYQALEVIVPFYENDSFMLKFFSENYQHEINIKCQNSRQKRTIIQRIIDKKNQKTNLYLELFNEFSTQFKAFLLPIAQNNEQTQKLKFPGSFSVEIFSNISLSQKYQAIIELQESFGTISYHQFPNSYFEFFYSGNELFFDHLKNPKILKLRLKKPNFAREFILLFNRKSHKHMFIQHFAEIYRLKNFVYDSGNQYKNDQETEENFFSESNEDKSKIEKFVQNHSINEVLNIEEDENEPDLDPDELEKEQEMEDLETMAKNQENELENEKNGNDQETNPHNKVFSTNFITKNYKICGIVVCDAQNVINCKVGSKIVKTFRILNPFLFIVQKEKIVIIRDDKTRISFQFLERQDLIRFVDHFNQVRNNFHLVKILQSSIPIKISNKIFISSDLNCLIISTSIEEIVFSYEKIDFVFSPTKPLLKLILDQKEEVFCQFQSSLVMKEFREKLERDLNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSZ2</accession>
    <name>A0A9Q0LSZ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSZ2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="306" mass="36342" checksum="DC70003E67F19749" modified="2023-09-13" version="1">MNSTKNKRQKQKKKRILQKKKNKIKNKIKNQNQNQIKNQNQNQNQNQNKNKNQNQNKIILSKEKIKKYLKPKSKCFKIEFNPQDFYDFNQDSYSNELQKSNLFNSNISSKKIFVKKQRRSILIQILNLLENDDTIYPLIPVPESFDHEVYFGQIPQSKNNFYAEITLKISILSTLIKGKHSSNFSVFAERAELFFQIEQYHDCICDCLRSLKLYPSIKVFQLCGQSWINLGEYLIGLPYFLTALTLDPFDKILSQKAKENLKILENKSIQKLKQNPKNEKLKDQLQRIKLSRENFEKFFKSNENEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT29</accession>
    <name>A0A9Q0LT29_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol n-acetylglucosaminyltransferase subunit h</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT29"/>
    <dbReference type="OMA" id="IFDSIHI"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="5">
        <location>
            <begin position="79"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="218" mass="25579" checksum="89073351AB1BF822" modified="2023-09-13" version="1">MVLTFSEKRINDGIIKFSIYTNAKYIRLVDKILFYTIIFFITITTSLRQEFSITKFAWVLIGLLIIHLFTNFFQVRSESLWIIPELGIQFNKKYLSGSKTKKFYDKDRMKNVIINEGITRFQIIFYIGFIIEGEHKLVMPFTHLYPKLKDLKRIYNQVQDIFFSESKSKDSGEQNLQNDDNDNDNDSDNDSDSDNDNKGDDSENLESQSDDDNSLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT85</accession>
    <name>A0A9Q0LT85_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT85"/>
    <dbReference type="OMA" id="TETHRHR"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="123" mass="15125" checksum="4F377B6F5423343B" modified="2023-09-13" version="1">MNSFNREWKIKTKSEKNQETKQETKQSKQKQNKTKNKTRNKSRNKSRNNFETKEWKIKTKSEKNQQKKSKKHKRKQRKQQKKQETKQETKQETKQETKQETKRETKQETKQETKQKTISKPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTL1</accession>
    <name>A0A9Q0LTL1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 9"/>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTL1"/>
    <dbReference type="OMA" id="RWLTHIN"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5078782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="59724" checksum="C32E3C14E8CE3120" modified="2023-09-13" version="1">MASHDRKKETRSNQEVEKDLQKINQYEKIKEEMIKRRSTKIYDKESLELSEKLVLINPDLYFVWNFRKEIILFLEKNPNEDLEEIYQKELLLIQKCLIKHPKSYFTWFQRKWITVRMNNCNWPHELILCKKFLAVDERNFHCWNYRRFVVEKGKQSLQDEWEFTTEKIEQNFSNYSAWHNRTKLLNKINKLDDSKTDEKLTPFNFRNELDFVTQAFYTDPDDQSGWIYHRWLTHINNSLEVINHEIEMCEDLLSLEPESKWTLFTLVLLLLQKIKNYEKKKQSFQRILEILLKLKIIDPIHYQYYQDLSSEILTDYFLFEKENQKENEKEIQIIPSLTDPNIQFTINLSKLNLSIQNVEFSRIIFRTNFFSIKNLDLSNNKITSLSGLQQFQSIEQVNLDNNQIQIIPIIILAKLPNLINFSCRNNLVNSFDEGYDGDFLDQNETEKKTNKNQKLNLKLQVLNLKENPIKETKEYQDLIIQFFPNLILLDEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTM3</accession>
    <name>A0A9Q0LTM3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Developmentally-regulated gtp-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTM3"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="289"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="367" mass="41069" checksum="599D96F88B0AA7CF" modified="2023-09-13" version="1">MGIADKIKEIEDEIARTQKNKATERHIGLLKARLAKYRMMLLEKTKSSGGKSEGFDVAKYGDARVALVGFPSVGKSSFLSQVTKTQSAIAEYAFTTLTAIPGIIKHEGATIQLLDLPGIIEGAATGKGRGRQVVAAARTADLILMVLDASNAEVERRLLEIELEEIGIRLNQQKPNVTYQQKRTGGIKFTTSCQLTHLDDKMATQILHEYRVHNAEILVREDITVDQFVDVIVGNAKYMKCMYLYNKIDTITMEEIDRLGRSDPNGLVCSCKFQLNLDRAVEKIWRTLDFMRIYTKKKGSPPDFVDPFVLPRGGVVGDFCKAIHKELFNRMRHAVVWGRSVKHSPQKVGKNHPLADEDVVQIVTKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUF5</accession>
    <name>A0A9Q0LUF5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoprotein tpr-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ERFEHEN"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="666"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="924"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1318" mass="158253" checksum="2B609C5DD5165BC5" modified="2023-09-13" version="1">MTDNLIKEKNQNENLQKLSEIYEKQIKKLNLKKNKLLEERNKFQIDLEQRVNDFELLSLKNKQLTNQLFEKNEKIENFEKEKNDNLKKIKELEKFKLKFEENLKEKEEIEKIEILKLKLQFPNQQSNQNQTTFQELQKENIQEKLIIKKIQEENNELKQSNQTIAKKLNQANEKIQQFEKKEKENQHLISSYIAEIEKKRELIEIFTQKFDQSKENDGKSQKKDDQTQTIKPTNQDQMEIESQIMNSFQNQLEILKQENMELKQKLENEDDQLSGKVLSKNMDTIMKIQGKSFSETFSDYIQLKAELKTEKEENQKLKEILERINWKLESKLPLIKEQEEKYERLKYSNKYLSDKLKEYIAKENSSKQTIEVLEKESLEKSKSIEILQEYNSNLGNQLKYLLSKDHNLKSGSINNEEKKEKEKEKQNENEKEIQNENENENENENENKIEMEMEMNIEDPKRNIQNPFFENLEDLQKTNEKLSIQIIELNRNYKNLEKELIQNFIKQFKPEIESLQSKLQNSYILSQNQMKLIFLMYLQRNQYRELLFDQLKSESHSEKDDLISKDLEKIMLELENQEKHQINLSDEKIIEGIQNNWNQFCKENCLENDLELQNEVYSLIKNDLFKENVEEMTIKDARKYLQQIYQKMELENDKRFRIIYILQQENISLTQKIKGLNERFEHENEQKKSQFKGVNEELLRSQTQNQILQEKVNVLTNAINIMKMEAANLHETIQRMNENANNLELTNQEIGSQYQLLEKTLNESEIQKQRLTSEMESLKRNQSKISQENEQLKSDKKQIKLLFSNFQDYHTSSQSLLHQKNIQLTISVQDLEKQNQELKSKIELMKLELDEKVKQMDQLQEEIKKVQLSKPAIKPFSVKFPQIDIPINSTETDSDQSILKFGNSYNENILKQEIQNQIESKKEILKLSQINEKEKNRLMKQNKELENENKQITELKKEQEHQKNQEIRKLTQNKEQLEKKMAEKDLGLITKEQKIFEYEEQFIELENKIQELEKKNQELAQMNQEIQKKAKLEIESSDLKYEKEFSNHVMDLNKLREEEKENEELKESQRIMGMEIQQLHKKLDSLEKQNEMLKMQLNLVKKEFELHQSQSEEISISTKQEISEQKKNIIETLENEMRIIQAENENLRFENQRINEELKNRGTLSSFSIQKNTPKIEEIFTSFDDNNPYQGKLKEESFQQLFKENKDLKEKLSKKLKEFQKLENEMEIWKKKERSLSENINVLNLDKQKLLKENERWKTRIAEMFQKYDYVGKNITSIIARSFENEFESFAVSLQKSYNFVQQQMAILTEKQRIYSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUG3</accession>
    <name>A0A9Q0LUG3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_14581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000036">
        <property type="protein sequence ID" value="KAJ5079147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUG3"/>
    <dbReference type="OMA" id="KTWKQIS"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="484"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="649"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="743"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="875"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5079147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1111" mass="129521" checksum="720465D9C3970DEA" modified="2023-09-13" version="1">MIHHIVVDNFKSYAGKHYIGPFHKNFTSVVGPNGSGKSNVIDSMLFVFGKRAKQIRQSKLSELIHNSEQHQNIKQASVTVYFQEIIDESDDSYQVVENSQFWVQRVVKKKGGSSYFINDKKSNFTEVISLLKERAIDLDHNRFLILQGEVEQIALMKPKAQSDHEEGLLEYLEDIIGSNRFIPLIEEAEKEVESFNEKRSAQLNVVKVIEKEKDSLEGAKNEAEDYLAKQKQLLEKKSILINLAGLKASKNIKSVEEKKLELEEKLEFERKKVEERTNELRSLEKHLKKVKKKDIKCQESFKHNESSFKNLRKKSKKKKKKNKNIKKLKKKVKKAIEDSEKKLQDLSDKLIQAEEVLEKMYKELQDKTTEIRNELEMKQKEIIPLNEDVSLWQSKNNLEKNSKIIEENKKKIKENQKEERKKTKLLESLKQKNEKNSQEIEKLQHETRKISTQIDEEKKAREQTKSQGKLYDEIRKASKRGVLTGFHGRLGELGKINEKYDIAISTACSALYNLVLETTEDGQKCIEFLREFNLGRATCIILEKIEHLRKAMEAPIKTPENIPRLFDLIEFKKDSYKIAFYYALRDTLVAEDLSQAKRVAFNYKTRYRVVTLQGQLIDISGTMSGGGKKILKGGMNTKMDTPILSKQEMQEMEKKLLQKQEQLKQFENQKLEMEKQIKNLIDEISQHQLEIKKLNMAIDSLLAQNKEIEQQIPIFVSQSKEDPKDEKRIQTLNKSIIDFKKKLEKSVSKRDEVESEIEKLSQKIREVGGAKLAKQEEEVSSLKTNIEETNKIVAKSKALIKTSERTIERSKKTIENTKKEYTKVGEEKKKIVEEISQIEKEALVVRQAYLNAQKFNFRSIEVDIMNQLDDYKRFMKTNTQKTEQCKEEIAKLQKQFKRKIALNEEEELQIINSEEELEKFKRKRSIQEYRKKEQEYSEKLTKLDQITSEREKARENYDNLRNRLEEFMTGFAEITMKLKEMYQMITLGGDAELELTCSKSWKNISNLSGGEKTLSSLALVFALHHYKPTPFYVMDEIDAALDFRNVSIVGNYIKERTKNAQFIIISLRNSMFELADRLVGIYKTHNCTKSIAIDPNSFSISKNVKNNNQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUQ6</accession>
    <name>A0A9Q0LUQ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000043">
        <property type="protein sequence ID" value="KAJ5079021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUQ6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040374500" evidence="2">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="91" mass="10805" checksum="0A2654ACD509BC5E" modified="2023-09-13" version="1">MVKMKFLFGIGISYLSLMNELTANPYVISGTTNGVVKIWKNCFIQNQNKNENENENENENYNHHEKNENQNENENENQNENQKSRNFKSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV01</accession>
    <name>A0A9Q0LV01_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13695</name>
        <name evidence="6" type="ORF">M0811_14245</name>
        <name evidence="7" type="ORF">M0811_14246</name>
        <name evidence="4" type="ORF">M0811_14472</name>
        <name evidence="5" type="ORF">M0811_14473</name>
        <name evidence="2" type="ORF">M0811_14609</name>
        <name evidence="3" type="ORF">M0811_14612</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000145">
        <property type="protein sequence ID" value="KAJ5066369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000038">
        <property type="protein sequence ID" value="KAJ5079103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000038">
        <property type="protein sequence ID" value="KAJ5079106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000030">
        <property type="protein sequence ID" value="KAJ5079516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000030">
        <property type="protein sequence ID" value="KAJ5079517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000017">
        <property type="protein sequence ID" value="KAJ5080004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000017">
        <property type="protein sequence ID" value="KAJ5080005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV01"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5080004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5080005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="66" mass="7258" checksum="C3597EE5EE356CB7" modified="2023-09-13" version="1">MFIFGNVLSFEISHPPKEKAGVNILTRSSTEPPRRSVAERPKAGALGEVKLKDIGAFTRKTTKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV21</accession>
    <name>A0A9Q0LV21_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Golgin subfamily a member 6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV21"/>
    <dbReference type="OMA" id="DEDKHIN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="21922" checksum="9823DF1B6CDDF0F2" modified="2023-09-13" version="1">MMGSQKEIETNSQLLIHTDEETYQKIPQIHMILKSKSKSKSKSKSKSKSKSKSKSTESNSTSTKSIKSASTNSTSTKSKSKSKHSTSTESNSTSTNSTSTKSNSKSKIKNQKSKIKNQKSKIKNQKSKIKNQKSKIKNQKSKIKNQKSKIKNQKSKIKNQKSKQSIFYSSRSRYFFSRRFFSIQNPRYISRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVX9</accession>
    <name>A0A9Q0LVX9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000028">
        <property type="protein sequence ID" value="KAJ5079534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVX9"/>
    <dbReference type="OrthoDB" id="9988443at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18965" checksum="B089BE6F5C8A6B8D" modified="2023-09-13" version="1">MCFDHSSRIYVPAVYAISTSSKQDMYTFIFENIFRYFLNSKWKFKYVTCDFEVSLQNAIKKVLPEAQLIELDENQKKELVESLEELTYIPLNMIEEKLKKIKVHFKGCEEFFKYFQKIWMRKYSPQIWNISSFPDLSQRTNGPLEGYHKKIKQKNWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW41</accession>
    <name>A0A9Q0LW41_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sin3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000012">
        <property type="protein sequence ID" value="KAJ5080148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW41"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sin3 C-terminal" evidence="2">
        <location>
            <begin position="102"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="519" mass="62080" checksum="FED3C32ABD26BBD9" modified="2023-09-13" version="1">MKMKIQNENENENENENENENENENENENENENENENENENENENENENQNENENENESENENENENHNHNQNQNQNQNININQNININQNINQKHSERVLLFGGKYYYYFFRKLVFLHKRLIDAKQTLYNTYESLLHRKQQKKQLLFPPSNEQPKNSSRHVLLSRFLKEKIPKEGFYASFIKLISDKLENKISSKDYEVECRDLFGSEAYKYLSIDKIIGSLIMSIAEILTSKKEIHSSFFISKKSIEVTGNVNWILSTFLSNIENEKYYFRFEYEEKNNKQDKIGKKPNEKSNEKSNEKSNQKSNQKSMNIEKKIESSRFSIKTVDIEEIKETSSFNNSQNYLFSSTHYSIINTLPFGLTPKDLKKITKNQLFFVPNLLHWNKIVSNEESEDESNSEFDENENNENEINEDENEINEDEDEDESENESENEIEIDDEIEIDDEIDEKYFKTPKKIDQQKFTQIISKNVFQSDSFQDFQNQKKNYNIQRIKPKEDFFYRWYSIVVSENYKQENRDKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWM7</accession>
    <name>A0A9Q0LWM7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_03827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWM7"/>
    <dbReference type="OMA" id="WVGRSAF"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5080342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="532" mass="63833" checksum="B1ED750BD21B2300" modified="2023-09-13" version="1">MNYNELFFFILFLIKHFSQYFFKLFLRLIFSGKLYRYFKTKKITNHNKEVNKISRQIRKNYELLSKEKTERRLVLYRKKGLAHITRDDSFKKGYTKINIEKLNKIISIDTKKKIMQVEPRVTIEDLFDFTFHYGLIPKISPEFKGITVGGAVLGNGLESSSFKYGLFERIVTEMEIIIGNGDVIKISKDKNPDLFYAFPGSHGTLGILTLLTIELTDALPFVELKYRKFKDVKSGVNCLNDIMKENSCDFLDAIMFSRSNFIVIEGHMKIKTTFSMRFYWHEIFYRHVFQITQNNHNHNPHDILRLREYLFRYDRYGFWVGYLEWSRTLKKRIIYGWLQSSTLLFRMRTFWKYPDLEFSGFVQDYLIPIDNSEKFIDFAVEKIFVFPIWFCPLNPNTSNIQDKKRLIFSLHEEMILKSDEKKESEKNEKNNNQNPFFIDIGIYGWPDPKGFTGNYKYYFDDINREFEKITFELDGKKGLYSANYYSKELFWKIYDEKRYNQLRKEFQASKIFPDIYEKLGHSGWKKRTQKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWQ2</accession>
    <name>A0A9Q0LWQ2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWQ2"/>
    <dbReference type="OMA" id="RVSMYMH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="255" mass="27808" checksum="BD727A133B888C5F" modified="2023-09-13" version="1">MSGIGTGYDVTPTTYSPEGRIFQVEYAARSVENSSTAIGIRVSDGVIFGVEKKIISKMLVKGSNRRVGSVGDHIGASIAGLTADGRRIIKQANSEAKSYKDLTSEAIPLNVLVDRISSFVQMHTLYASIRPFGCAVMFGSYNEKDGAQLFLVEPSGVSFGYYGCAIGKAKQSAKTEIEKLNLSELTCREAIKQVAKIIYTIHDESKDKEMELEMSWICKESGGKHELVPDDLIAEAEQFAKDNTVSTNILNFDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYY2</accession>
    <name>A0A9Q0LYY2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_14267</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000018">
        <property type="protein sequence ID" value="KAJ5079988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYY2"/>
    <dbReference type="OMA" id="CIACELT"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="ArnT-like N-terminal" evidence="11">
        <location>
            <begin position="55"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Protein O-mannosyl-transferase C-terminal four TM" evidence="12">
        <location>
            <begin position="333"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Protein O-mannosyl-transferase C-terminal four TM" evidence="12">
        <location>
            <begin position="473"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5079988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="572" mass="66483" checksum="DC3EB59B272C9A10" modified="2023-09-13" version="1">MTENKKALKVTFASENENEIDLNQIASFNLKKTQKSHRKFNQIGKKTETIILFISLAISFTTRFWKLSHPKETLLPEISTGKSINHYLLGEFFAGQKPPFANMLMSFVAKICATKPALTFTSPGEQIPPDFPLTCLRTASTFFGSLVPELVYLVTRSMGGSVIASFLAASMIIFENTMIVQSHLISTNSFVLLLVISAVFFALKETHLRPLSKKSLFAMSLSAVSLGMAISSEPFSWVTFIFIILFQIINIFRQKNQKKIIIFKRILSIFVIFFAFAIVIFIISYNFHFNFLPFNENDNLEQKTMLYSDGLIQSADSKQAGFGFLPDFLSQIHSQENIIDESAEIYSNEMKVQNYASNWHQWLLHTSKAVELWRKDSTDITEPKQYIYSIGNPFVWWIVFFCVIFIIFNFLMINENTNTTENKNKNKNENENENTTENENENENKNLKRKNSVSHLIYTRYDYLLDMISTNSFNLFFLLCGYFIHLLPIFRKDKFLFNYDYQYSLLFGIILASLVIDFILSTLTSDQVFEMIIACTIWVIVIFGWFFFIPIIYGYDIDVYAFQKRFWFKSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4S7</accession>
    <name>A0A9Q0R4S7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000141">
        <property type="protein sequence ID" value="KAJ5066508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4S7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="117" mass="14315" checksum="11C5E17A6ABDF0B0" modified="2023-09-13" version="1">MKNTVTQTMNMVNDESEQISSKNKLFKKKNEEFQHFQSIYNEKLKKFIQKKQELNEKDNDNQKKEFWLQKKEKELLELEKSLETKQMAQKATAQRLKDWEKQLRSKNKHLKKPEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R579</accession>
    <name>A0A9Q0R579_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R579"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="245" mass="28157" checksum="04FE742D8FB6BC5D" modified="2023-09-13" version="1">MDYNFSFQKTIITDLSQYQLGSSSGCVIMATEASLLLIEKGIEITEQELEQILVNGMFKYENLQNIFGTESTHFGFSEVKNLAFEGEFKPLEETMKTQVLLLDYQANWVTQFVSVVKKNKFQRLQLLHLGMNGAGFLFFHSLKDLQNYLKIRFPPISGISQFDTFQSVINQVEVNSFGVFKKSENQILLENQLSNLLSNLDFSQKEKKEEKEEKDGKDSNQIDFGSLMDLLNQSLENQNQNKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5T0</accession>
    <name>A0A9Q0R5T0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gtp-binding protein rho4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5T0"/>
    <dbReference type="OMA" id="SFHECSA"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001179">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="189" mass="21378" checksum="DAD0627CFA112F2C" modified="2023-09-13" version="1">MPRFKLVVIGDGAVGKTALCMTFASNEFPEEHIPTVFEQHVRDIDFENKTYELEIFDTAGQEDLGRIRSLSYNGANALIVCYSVDLMSSFHDVKENWIKEGRHYCPKAPIILVALKSDLRKDQEAIDKLTKANQSFVTIEQGKKLSEEIQAYSFHECSAKLKENIDDVFIDALKASKENIKKESGCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6A5</accession>
    <name>A0A9Q0R6A5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Intein-containing cytoplasmic dynein 1 heavy chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_12199</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14187at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="14">
        <location>
            <begin position="735"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="14">
        <location>
            <begin position="1436"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1841"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2055"/>
            <end position="2110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5068892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3298" mass="379968" checksum="5A21B079817B2573" modified="2023-09-13" version="1">MLSAVSQQIQTIQLSLKEQLKEVELIGRNVKINPNMGIFITMNPGYTGRVQLPENLKTLFRTISVVKPDRELIAQVMLFSQGFKTAEQLSGKVVPLFNLCADQLSPQKHYDFGLRALKSVLVSAGNIKRLEIKDKKQDEVKDKKQLGEEEKSVVIKSICETVIPKLVADDIPLLHSLLSDVFPGALPIELEMAELRNVIYDICKKHYLVPGNRWIEKMLQLFQLQKIHHGVMMVGPSGSGKSTAWKILLEALERVEGIKSQSHVIDPKAITKEELFGVLDPTTREWTDGIFTHILRKIVDNVRGESNMRHWIIFDGDVDSIWVENLNSVLDDNKILTLPNGERVALTPNVRVMFEVQDLRYATPATVSRCGMVWFSDDIISLDMNFAHYLEKTKHVPLLESEKTGFEEQLSDEKEKNEELLRTQEICVDALKKYFDSNGVVIKAIDYASKKQNVMDFTNLRSLTSAFSLLDQGINHIHEYNSTHSGFQWKRNISKKYVTKRLLFSLIWGFGGSMSLQDREEFGTFLLNNCDIQGPEDKMHPLIDFEVQIEDGEWALWKNRVPNLEIETYMVASSDVVIPTVDTLRHEEVVNSWLKDHLPLILCGPPGSGKSLRNSATVYTPNGPKINGKLKIGDVVCTPDGKTSKIIGIYPQGKLHVYRVKFEDGDFVDCSADHLWTVNDHSNYKKQKFVLTTQQIIDNLQIIPTIPERKGARFSIDTPKPILFMERNVPFDPYLLGVLIGKEEIYIGNENIEKQNHYKEILEELGLLNQPKDKLFIPQDYIFNSKEIRLEIIKGLLDSNSSINYKDNSIIFKCKSTKLSQDFKKVIQSLGGMCSIETNSNKTNLCKIFYKTPKELFKLSKNKDKIGEPSPFVFERRIISIECVGEDECTCITIDHPEELYLTDNFVVTHNTMTLYSTLRSLPNFEVVGINFSSATTPELVMKTLTHYCKYQKTPNGVILEPTKLDKWLVIFCDEINLPKQDRYGTQKVITFLRQLVERGGFWRISDYQWVTTRRIQFVGACNPPTMVGRVPLSHRFLRHAPVILVDYPSADSLKQIYGTFNRAVLRLCPTLRSNARSLTDAMVEFYSLSQQRFTQDMQPHYVYSPRELSRWTRSLREILKPLGGDLDLDGLVRIFVHEGLRLFQDRLVYKEERDWTDEQLDSVSKKYFPGIREKTLERPILFSDWLSKDYMDVDREKLREHVKARLKVFYEEELNVKLVLFNEALDHILRIDRVLKQPQGHCLLIGSSGAGKCLDPNTPVMLYNGKSKLAKNIKVNDQLMGDDSNPRNVLSICKGRENMYRIKQSNGDEYIVNEPHILSLKLTINSILNHEKDLKRYSVLYFENHCEKIKYFNYGKKRKLSESKSFTSSLNALHFANKFINQILESKKYNHKGDVIDIAVIDYIKKPQIWKKYHVGFKVPIQFNSNPNIPIDPYNLGIYLGMENNKSDEEIKIPQCYKINDRETRLNILAGLIDSNDEIIYDEMNNCYNIPINENQEELYKDIQFISRSLGFSCEKEKEKIIISGNEIEEIPVRNPNKKIRNQNKIQNSNLESEIEVELIGEGDYCGFEIDGNRRFLLGDFTVTHNTVLSRFVAWMNGLSVFQIKISRKYTLFDFDEDLRVVMKRAGIKGEKICFIFDESNILETSFLERMNALLASGEVPGLFEGDEMGALMNQCREAAQSDGAILDTNDELFNWFTKQVQNNLHIVFTMNPATGDFSNRAATSPALFNRCVLDWFGDWSPSAMYQVGYEFTKDLNLENPNYFPPISFPHEFDAKDNFPDSPNHRESIVSSFVTIHKSVEKSSKKLQKTQGRSNYVTPRHYLDFITHYLNLFNEKRSSLEEQQHHLDVGLKKMKETEEEVAKLQLKLKQKEKELESKNEEAEAKLKQMVKDQQEAEAKRKASLEIQTKLEEQNKEIAAQQKIAMDDLSKAEPAVLAAKKSVNSIKKSHLEELKSMSNPPELVKMTLQAVSQFLGSKETSWGEIRRLLRKDDFIPSVVNFDTNSMTSKARDLVSKALADPKFTFENVNRASRACGPMQKWLEAQVQYSVVLEKVDPLKKQVASLEEKANILRDKQKELNDMIENLEKSIQRYTEEYAQLISQTQEIKSEMNLVSQKVERSIALMKSLSSEQERWSLESQSFQQQMSTVPGDVLLSASFLTYIGFFDQHYRQVLMNIWKKHLMTVNIKYREGLSLIEYLSVPDDRLIWQSNSLPADDLCTENAIILTRFNRYPLVIDPSGQATEFLMRQFESSKITKTSFLDDSFMKNLESALRFGTAILLQDVENIDPILNPVLNKEFHKSGGGVVIRLGDQEIYFSPSFNLFMTTRDPSFNFTPDLCSRVTFCNFTVTLESLQAQCLNHILRNERPDIDQQRSDILKLQGEYKVRLRNLEKSLLDALNKVEGNILDDDSVFNSLERLKTEAAEVAEKANQADQTLANITKISAKYEPFALSSSRIYFTLEQLSSIHYLYQYSLNFFLGIFFNVVNTMNQNIMNVQDYEERLKILTHDLFKVIYRRVSYGLLHKDRLTFALRLAQIYLKQMGQDFDEEEMNLLLRSDIILSPNKLQDKIDNSYYNIPESVIPSSQIKYLQIISELPSFKDLPSHIRKNQSEWKNFIKSANPESNIPENWETTKTTTNWIFRLLLLKFFRPDRVLSGTSSLIETVFGYNIQSIPELNLKNVIEKESNAREPLLLCTQPGYDPSTRVDELANELGVKKQSIAIGSQESYHHAEQAIETAAKIGSWVLIKNVHLAPPWLNQIEKRVRNINPEPGFRLFMTSEFNPKLPVNFLRLCQIFVFEAPPGIKANLSHTFSLLSSKRVNRAPVERARMHFILSWLHAVIQERLRYVPLGWSKIYEFNEADQRCSLDSIDYWVGSVAKGRSNVDPEKIPWIAIRTILGQVMYGGRIDNDFDQRLLDSMLEKLFVPKSYSLNFKLIEYDSLTEDGFDKFSLEIPEGTKMEHFADWIEKLPKNENPAWLGLPAKAELLLLANQGKETLGNFLKMENIYEEEKSDIEKEKKEDRRPSWMKKLEKSTREWIDILPKSLDSLKKTESSIKDPLFRCFNREIIIGKKLLNKVREDLEKILLLCQGKQKHTNYLRGLIRDLTQATIPSSWRVYSVANIPVGIWIVDFSKRIKQLQKIILSKNYCLDGIWLGGLFSPEAFITATRQSAAQSNMWSLETLKLEIEIGKFTQSKFKNTSFFVDDFTLEGAIWKNNCLAISSDISNPLPRVQLRWVPNQENELNVKSKVGSDLINLPVYLNNTRKELLFSLDLTTPKDVPIQTWYQRGTALIVWSSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6J7</accession>
    <name>A0A9Q0R6J7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U11/u12 small nuclear ribonucleoprotein 25 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6J7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040610">
        <property type="entry name" value="SNRNP25_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18036">
        <property type="entry name" value="Ubiquitin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="SNRNP25 ubiquitin-like" evidence="1">
        <location>
            <begin position="42"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="17612" checksum="B235DD2C7BC13F1F" modified="2023-09-13" version="1">MISKNLLNLLKDPIFKDIPQNINIEIIDALIEIEKGFGWILFIEQFMGKTFEIPVIQTQNLKQFKKSFQIIFENSQTNKKIKISWKYIWKHYFLVFKLDDKKYRLSNEDNNRKLEEIGIKNGTIFHFEKRLIRKRNKQNLNQNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R711</accession>
    <name>A0A9Q0R711_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R711"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="176" mass="20943" checksum="501027DA3ABF8812" modified="2023-09-13" version="1">MFSIFPFLKTSIKKTFQPNILNKKCYKIIFIGTENLENEDPKLHFVKIPDSCFTNLLEIFNEIIKDLDEIKTKYENELKNNPKSLKENQLLLYSSNYEILNGILICFLLFRMDFTIEQILNNFSVDFIVSNSFLFNQILQIEKIVRNQNSITYDDILEHIQEKNSKKWKSVKMKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R723</accession>
    <name>A0A9Q0R723_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5069026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018448at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32158:SF21">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32158">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1727"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1752"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1782"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1824"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2033"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2077"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2100" mass="235028" checksum="E1DD97E7B2F5F22E" modified="2023-09-13" version="1">MIKIKKTLKKIQNNILIQILIGIIITTLIGKVSTAKIFVSVDGKSSDCDFSDGSKLCDLIPRAVNKCVSGDEIYVYSGEYSFLNCNWWTNKGIAIKGIGGNVIIDCGGSTFGFGFNGLDDVYLENIEIRNGLLMSSKFQGNGGPAITVRNANITIKNCIFSYNQVVLGAVNGNVFAGAVLIEDSPNVLIQDSSFFNNTNPNNGGGAISIVLRNVSVSPVFIDFSQNSISGNSGESGGLEIYYLESFNDTISQINQNNFYNNLGSASGAILVKSIEENYNASFEFKQNNITTNDGSSFGGIGMVYFSECNNLNLLVDSNYITNNHGREVAGGFAAKYNEFLNNTYIQISNNFISGNIGYSGGIAIGLDNLEYMTEGQDIANQLYILNNQFIYNIGENGGACYIHAPILAYTQNNTIDNNQALQGAGFYLRDINSFSSSNTKFGANDATVGSEIFFMSIGQISLEGNEWSIAKPYDSVLFFLTSTSPIFTNFDFYCAQGDDYNKSITSPQTLVNKYKELMKIQCLPCPVGTYSLQKGTNHMGIQQCFDCPQEGLCKGSAAIYSKLGFNGIEQENGIIKFFPCPPNFCSAPSIENTTLLLYNECYNNRKGILCSQCEDNYTETLMPGEVCKPLKDCQDQVGIYILLLIPKAIWIVWSFLKIQHGSTANFHIFTFFFQILRIVLPSMESKKKDFFWMFLLSFSDIFNLQAYLPIFYNFGECPSSSSINSIQKLLMRLIGPFSTILLACFIYIIVLFKHQKLRKQNMFEITGTPTDTDSDTNTDSKADDDYKDYKNYVREYIDNSNGQSSPDELKLLENEAKSFSLEDSGKNTSDNNHQRGKEQANFNSQNHRGSSQMKSTKTEQKIILLIKKTRIGFLKSNFIAEVNRVSYVSRPLLTRINITVATLLFLTYPVVLDVVFNLTSCLVLGILPNTNQKRLFLYPELVCYNPIQKFLIFLAVVLSLLPFALFYILFKSKRVVHKICVLNIFYNPFRSKFYWFGILMMIWKVLLLIFQAYITNPITNATISTIFCIVFLITHLILKPFISIRANNIQTLSLTLLTIISSLKIPQSIWGIGGIIPFVSSTKKTSYGLYYFSFSLCVGFIVYSIGLYFRMIKRNSKNFIGFSTAKMFVSVDGKSKQCYYSEGEALCDLISRAVNKCVSGDEIYVYSGEYSSSNCNWWTNKSISIKGIGGNVIIDCGGSTFGFGFNGLGNVYLENIEIRNTKLMSWEFQGNGGPAITVRNANITIKNCIFSYNQVVLGAVNGDVFAGAVLIEDSPNVLIQDSSFFNNTNPNNGGGAISIVLRNVSVSPVFIDFSQNSISGNSGESGGLEIYYLESFNDTMFQINQNNFYNNLGSASGAILVKSIEENYNLSFEFKQNNITINNGSSFGGIGMVYFSECNNLNLLVDSNYITNNHGREVAGGFGLKFNGLMNDVVLQFDNNNISGNSGYSGGIAVGLDNLEYMTEGQDIANQLYILNNQFIYNIGENGGACYIHAPILAYTQNNTIDNNQALQGAGFYLRDINSFSSSNTKFGANDATVGSEIFFMSIGQISLEGNEWSIAKPHDTVLFFLTPTSPIFTNFDFYCAQGDQYNKYSQSTQTLVNKYKELMKIQCLPCPVGTYSLHKGTNHMGIQQCFDCPQEGLCKGSAAIYSKLGFNGIEQENGIIKFFPCPPNFCSAPSIENTTLLLYNECYNNRKGILCSQCEDNYTETLMPGEVCKPLKDCQDQVGIYILLLIPKAIWIVWSFLKIQHGSTANFHIFTFFFQILRIVLPSMESKKKDFFWMFLLSFSDIFNLQAYLPIFYNFGECPSSSSINSIQKLLMRLIGPFSTILLACFIYIIVLFKHQKLRKDNQFVEITGTPTDTDSEEEYNYKDYKNYFREYIDNSNAQRSPDDLTLFDLDIAFSLEDSGKNTSDNNLQRGERINTRCYFVSFSKFTSIPKFGYLFTLVHLQFNKAKWHLAERHNIYTSDDLSSSSIVTDTLIRTPTDISEEDNTPNKKTRIGFLKSNFIAEVNRVSYVSIPFLTRINITVATLLFLTYPVVLDVVFNLTSCLVLGIPPNTNQKRLFLYPELVCYNPIQKFLIFLAVVLSLLPIRVILYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R785</accession>
    <name>A0A9Q0R785_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R785"/>
    <dbReference type="OMA" id="CKRDEVW"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="379" mass="45153" checksum="941A8774C9209AF3" modified="2023-09-13" version="1">MNIFETINYKSKQVIKIGKEHLNELKRGEYCEFAEYLKLSPLKENLILEMLPEEVLLYIFQYLSPGDLIRVASTCTTLNELSQDINTWRIITYNYNQFLILKEIEFEKEIIETKPNLSSFFRRRRNEDPFIISLEENEIERNLIEYIEKIPNPQKEIISKAKLIYNAILQRKQQKKLLKQFKERLFPFLFLLFAIITTFIILINVYIDNNLSSNILYFFIPLFIAILITIPFLFYLFKFLQDSKFSIYGIGTAILFIEVLLIGLRIETTIKGSWLLIFIPFFIFIGFIIIYYINLILKKNDLFYKLLLLLSIFVLFLIFLILLGLRLDETIKWNYGIIFIPFFLINLVPLVYNWLLFLVQNLIPFCVGFLTDIPVCFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7B2</accession>
    <name>A0A9Q0R7B2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7B2"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="507" mass="60696" checksum="C97E195CD74707CC" modified="2023-09-13" version="1">MNIFETTNYKSKQAIKIGREHLNELKRGEYCEFAEHLKLPPKEENLILEMLPEDIFLYIFKYLSPGDLIRVASTCTTLNELSQDINTWRIITYNYNQFLILKEIEFEKRDNVYQENEIPIYGIIEKLKSLTNNNIDNEFITDSGFITEFITDSEFDKKSNLINLNPKQKLSETKPNLSSFFRRRRNEDPFIISLEENEIERNLIEYIEKIPNPQKEIISKAKLIYNSILERKQQIDKNIKIRRKQERRRKQKEARRQFLKQYKHQLLSLLFFLLITIFVSIILINVYIDNNLSSNILYFFIPLFISILITASFFFYLYKVLQDSEILIYETGMIILFIELLLIGLRIETTIKGSWLLIFIPFFIFIGFIIIYYINLILKKNDLFYKLLLLSIFVLFLIFLILLGLRLDETIKSNYGIIFIPFFLINLVTFIILFYLIYGKYKRIMIFIILAGILLFEILLVLFIEGSISRITYVFIPLYYFLVFNFLFCFFVLFLIFNVLPFVCFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7U9</accession>
    <name>A0A9Q0R7U9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide exchange protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7U9"/>
    <dbReference type="OMA" id="CLNIFFP"/>
    <dbReference type="OrthoDB" id="2289278at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31334:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE PROTEIN SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31334">
        <property type="entry name" value="SMITH-MAGENIS SYNDROME REGION GENE 8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="484"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="987" mass="117316" checksum="E9B5A4576362536F" modified="2023-09-13" version="1">MNKSNPKFTDLILLSEFCQQKGPSVLYSFPTQTQPLTEIALQVMSTNYQTSQVGKLMEDTQFVIKIRRENEKTLYAYVHHFTLFDVQARGCVRPLCFSYLSTSYDKIMSNFIAFLIQFSKITSLLKLDNLLTFLLQIEIREKDLLYSKEKFDTNSHKDFEVHFLLLPEFIIDLKKIKKSIIKSISTKLASFLLYIAQIKDRKWNYFFDNPEIEKLNIKDKLKSYIRYIASFYEPKLFKYTSPDDALDSIETNLSKNFYHHIIINYIHPLFFEFSISQACHLFNSNLITKSSQSTFLLNIGQIPDIDFSFSNINQDFFDKNIISFLNLDNMKIKIKIKIQNQNQNQNQNQNQNQNKNENINQNQNENQNENQNQNQNINQNINENQNQNQNQNQNENQNINENQNINENQNKNENNNENQNQNNNENENENENQNQNGNQNQNINENQNKNQNQNKNKNQNQIQIENENNQNQNINENKNENKNENQNQNQNQNQNQNQNQNQNQNQNENINQNQNENQNENQNINENINENENKNENQNINQNINENQNQNKNQNQNQNQNQNQNKNKNQNINQNQNQNQNQNQNQNQNQNQNQNQIENQNQNHKIKNQNQNQNQNQNQNQNQIENQNQNINENQKYILIDDYLSNIPENKTQTKEITFDMNFQDQNRFRSSIKRTSSYQKELFNKTFLTTKSENNLLANIYDQEIETKPQENWSFLDLFHSFNINSLGKGLTLREIDKIVNQLNWCLDQVLFAIFTGRLLIIYTDEDKKENVEKMIKFLSLFIPGNCHVDFWRKSPINFFEMEKLKICGLSNDIEIPKKILPFVSLLDLQKNEIHSPSYANPITKKHFLFKIISTFKYFSKKEIFLSLIHQNIYEFSLKADIYFHVLMNNQFPTSNLFFGNFQIEKLNDIYGIDSNFLTNSYFNLNLNLNEMKILKILEVYEHDLQILMYFIRLITAQIVSENSSQNTIQSKIHLDFRNSNIKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7X4</accession>
    <name>A0A9Q0R7X4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_10811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the maintenance of the Golgi structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7X4"/>
    <dbReference type="OMA" id="SWIITMW"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF7">
        <property type="entry name" value="PROTEIN YIPF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="10">
        <location>
            <begin position="128"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5070542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="267" mass="30776" checksum="AB6EEAE2D5CD199A" modified="2023-09-13" version="1">MAEDPNKNEDKFEENSLEFIANEIIPKENEEKTGKKENEMGNNLITKLGAKYLQQKYGWILSADEQESEDEDEEMSILEELEINPKKLVEKSLAIFQPSKNYNIFGEKDYLPDYENQKLNSDSNLIDMEDDSDDFWGPLICSLLFSVFSSSLKFKGTIWIIFVWFVGSLFISYVSTFLGSKCSFSRALSIIGYSLTPMTIANILNLLLFYFLGNSVTFFSYLIFFFSILYSTYCASTLIPQIDFHVSGKKYLLAYPIFLLFVYLISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7X8</accession>
    <name>A0A9Q0R7X8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_11797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7X8"/>
    <dbReference type="OMA" id="ENEVKMW"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="196"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5069179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="352" mass="39180" checksum="1696C3BE856AA319" modified="2023-09-13" version="1">MTEKEKVAIIGSGNWGSAIARIIATNTAKHENIFEKETKIWVFEELIDGQKLTEIMNTKHENVKYLPGITLPENLIAEPDLIKSVDGATILVFVLPHQFISRTLSTIKEHIKKGCRAITLIKGFVVDDQDEIHLISDMISESLGIQVSALMGANVANEVAQDMFCETTIGCADQKDQEMYLKLFNTKTFRVSTVSDVYGVEICGSLKNIVALGAGFCDGLSFGGNSKAAIMRIGLLEMKKFAQMFYKGVESETFFESCGVADLITTCVGGRNRKVAEAFVKTGKSWNDLEAELLNGQKLQGTLTCDEVHRFLTKKGKIEEFPLFFTIYLIAQKKVEPLRVFDFDEVTTEFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R872</accession>
    <name>A0A9Q0R872_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hermansky-pudlak syndrome 4 protein light-ear protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R872"/>
    <dbReference type="OrthoDB" id="16754at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026091">
        <property type="entry name" value="HPS4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407:SF9">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14407">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 4 PROTEIN LIGHT-EAR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="630" mass="74485" checksum="ADF4EF35FBE4A5F2" modified="2023-09-13" version="1">MNLENTQNPFNEGFICWIKEICLEEIENEDEQPEKCLCIFPPKINKQMQEKLAGAILSIRDSMKNLTPNNLDIVSLSTLKISVIPIGDSILSVFAQSSLNIIDETLREHHHFFIDCFKFFNHSIKHLRERAEGSEDYFKSLLEQATRELVPLLFSKMFDLTNLLLSPFHHLPYFDFPKGSRRFFLLATQIIEEIQLTDGCIDACLLYDNKYICGSLDFVSTQYSYIRLLYLTEKELQQFKITDEKIEDFELFGYSTENLRKQLLIESEKDFTILESVPVFFFKNKNDKNFENENESENQNQNQNQNQIENQNQNQNQNQIQNQNQNQNQNQNQNQNQIENQNQIENQNQIQNQNQNQNQIENQIENENENNNNNNNNNNNNNHYNFYNFSNQDQIKRSHSQGYSFSMLKKNGLNSPVLIKSTKSESYDQLSKKDMNQLFRYNSRYGEKIPEVFLKKHQDGKYLGLTISKFKELSFIIITQLSRIFDEKKIKTIQTKFHSKMKKLHNYLVSSPKPNSVKQSPKQNLNPNSIIFDRFLKKISISDIDPYIENDFQFLRTSSICHNIFHSNEEISQLILENYSGTFFSRVTPSREIFFHKPFPQKKKKQFNSLEKIETEARNYISQKYKTNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8K0</accession>
    <name>A0A9Q0R8K0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exonuclease v</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8K0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="167" mass="20272" checksum="BE6C83770FFE5566" modified="2023-09-13" version="1">MVEIIFSHLRCLMDKNSQTRDLLIDSQLKLQKLREDMKNPFLKKLYEFVKNKVPLKEVRRRFRTKRKECLMDQFNKKDKTLQKDHQTLEESMRFMTISNSWKELIQSHTLIEYAKTKLKINETPKEIPDTNQEKNLTESTEKKNKKLSIHFFFLISFSFIRFNNSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R976</accession>
    <name>A0A9Q0R976_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase RNF170</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RING finger protein 170</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RING-type E3 ubiquitin transferase RNF170</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_10612</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R976"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5071128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="214" mass="25571" checksum="C84461DD9BECAA1E" modified="2023-09-13" version="1">MQVNIEELKCPICMQIFENCTQTNCGHAFCAECILTSINHNKYCPICRSEIFSLYPSYNLRKIAEQAKNTHQELHPKENSQPPKFWDEKIKEFNQKNHRPNLGLAGIRYDYNILTRVMTQRCNSYSFAAWFVFLLVLAYLVWPYDLIPNTEGLFGFLDDFLILIWGIWALHKIVSYFEESQRNRPNRVNEIRQRMRELRERNQNNQNDRNNQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9G6</accession>
    <name>A0A9Q0R9G6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9G6"/>
    <dbReference type="OMA" id="NLIRICT"/>
    <dbReference type="OrthoDB" id="10253982at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF31">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="338" mass="39807" checksum="C161D9A26769BC9B" modified="2023-09-13" version="1">MNFPHFSKLNKFSSKINFRELSTNLIRICTFNILSPQYNILESENKVKKESKFKEYWVPRVSSELNMIKKTESDVYCLQECWMNSSFIQIIQNKFGSNYSLIKKKRTRKKNDGILIAINNKKYNLLFENHLEFNDQGDRVCSLCHIQSKNNEKNELIISTTHLTFPHSKQDREMRLEQIKKCINWIKENTSMIIMNKKDQNDPNASYNLPLIFAGDFNDENDKVYNFITQKEAWNSSFLKVHGREPISTHKTHQGSHICVDYIFYKNSSKNDPNQIDLKEKKNLKEEKNLDNLTSSTSFISPVSAFLIPTTLDDQKFPTFLEFPYSDHRPLIVDFKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA00</accession>
    <name>A0A9Q0RA00_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate kinase 1 isoform b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA00"/>
    <dbReference type="OMA" id="MIEEHMR"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="215" mass="24952" checksum="419C947698FAE604" modified="2023-09-13" version="1">MQETEQKKQEIEHQKEQEKIQKLCQVVFVLGPPGAGKGTQSDLLEKEFGFVHVSAGELLRNEVEKKTEESEKINQLMKDGQLIPKEITTRLLRQNILENITEEKITTFLVDGFPRKIDQGEYFESTIKPCEFVLFLDSPNIEDLIKRIQERAKLSKRVDDNVDSFRKRIEGYKKDCLPVIDFYGKKGKVKEVIADSDIDSVYQKVRQCFLPEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA56</accession>
    <name>A0A9Q0RA56_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Methanogen homoaconitase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09528</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA56"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170034">
        <property type="term" value="P:L-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170038">
        <property type="term" value="P:proteinogenic amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000222">
        <property type="entry name" value="RAB32, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="513"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="792"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128408" checksum="6130DD84F270B2D4" modified="2023-09-13" version="1">MSQVDDEQEDHEFPYKVLVVGDSGTGKTSYINSFVHGIFSTKYKSTIGVDFALKVMKIDEKVVRLQLWDIAGQERYGNLTRVYYNGAAGAFVIFDVTRPNTFENAKKWKSDIDSKVYLSDGSPISVVLLANKIDLGSDIFEKTKEDMDNICQEFGFIGWFTTSAKTKENIDESVNFLVKKILENDQKIKKKEERNDPVINLTEFKPRPKKKCSKKPKSKKTKQIANFFITFNTFFYLKDPKKKRYFRRRRNESNEKTSVHLKNVVGLGSQENRRKKRFRKRNHKKIKLQSLKEFPELPKMEPIATKNTEVPILKPKHEQNIKFVSVFFGNKEIIMSQIDENPQKRKLAPPPPQAPLNYLEAAQCDPNSLQEISNISHLKKNNHSSNFSIPELRKRKLTEMQQLGGESKAFLHSNNNHNIRYIKRTSGRFIKLTEAFIQIEIRKNSAGNWQEIILYALSSSTIPLRNPNQPTTLHCNECLLSAENGISSSSHSNTLHKNKKNKHKLAMSQTIIEKILSKKTDQKVIPGEICDVFVDVRAARDFAGANVVKNIRNNGLTIEDNKRTFFTFDCNPTGSDMNYANNQQICRVFARERGIKVFDIDKGIGTHIVIDEKVVKPGDVFVSTDSHANIMGAICAFGQGMGDMDIAAAWTRGKVWFKIPHSVKVNLKGMPGKYATPKDVTLRILQVLGANSLLGYSAEIYGEYIDTLNLSSRITIASMATEMGAIILLFPPNESIFKELGFDPKEFDLSLFEADPNAKYEKEFDIDITNIGPLISRAGHPEDVVAVKDLFNTKIDSCILGSCTNGRYEDLKLAADIIKGNQVAPGVILKVVPSTQAIYLRCLREGIIQIFVEAGALVSNPGCSSCAAGQVGMTGVNEITLSTGNRNFIGKQGKGKVFLCSPQTVIASAISGVMTTVDNILEKPILFPEPEKNIRQIDNIQSQCENCAQPQTQTQTQTQQQIQTQDSELKEIAKPTQFTGRVWVIPKDNIDTDMIFHNKHLTITDINQMGQYAFGNLEGWTDFSKNAKKGDIILTGKNFGCGSSRQQAVDCFINLGISVIIAQSFGAIYERNAINAGLPILTLPVLDLKELDISDADVISVDLINGNILNKRTNVVVKANPCSKTQLEIYHRGGLLVSGVKSQSLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAI5</accession>
    <name>A0A9Q0RAI5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAI5"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="533"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="736"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="778" mass="91459" checksum="4D6E2F117032C55E" modified="2023-09-13" version="1">MFFYPNKKPNNPKNKIDKFDSHYLFGNSKWRQLTAKNGDKVELLKRRTETVVYGHKLWFFGGGISRTEVYDHFYNFDLRSHEVRKIEPNISFPPPPARWGHKACVLDNKMYVFGGHGKDSYLNDLWEYEFMTNKWVQINGNGEVPENRSDHSLTPYVSPQGKSFLFVYGGWDGDINEYHIDSFYRFDLESKVWSQIRSDSFIPEKMPVSLHVMFPYNNFLYIFSGKDHKNEVDTNRFFRYDISTDFWQKINPFQWQDDENIQQNLPDFQKLRSQRFLELKENHKKSKSNQKPKSNQYRFSFFRSISKKSVVAKPPPRTVSAGCVFDNKLLVFGGYTSFDDNILHYFDINKNSWFEVDTQQPVEEIPAPRFGHDLVLYENKLIACFGVSCMGSDLYNDIYELEMEYPLIDEMKIFFNDIRSSVYDIEFSTLDHQKVVANRCFISQRCPNVSLENIIIAFMSHLLVDVEDVLFYIYTGRYRQSNFTNSGLLSLSKRLELKHLERLCLCDSSNTNENQNTILEDYAKLYERRNENGDFILDVQGKEILTHRFMLAARSQLFCGMFLSVQDESNRVPDYSGRKPESIEKLIEFIYTHRLSSLSTPICLDLLGASSFFGLKDNTLDILCCRHLVSTSSITSENVLDIYDKILTFQIQEFQQEIEDFIRKNIDNIKDSSSWKKYIEIDPDRFIFLDQKPEVKEELNSENTNKDEYEDEQIRFFEALNSYHENQYLRNSDIDSYSESDDYYGDQNDDQNDDQNDDQNDGNDQNDGNGSGSTSQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAW6</accession>
    <name>A0A9Q0RAW6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-type lectin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAW6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="256" mass="29727" checksum="795DC345566653FD" modified="2023-09-13" version="1">MNQNQNEIFSTLYIAFSGGITGSFAQQITNKINDVEVDFDSISSSFINSAYKQAISDHYKKWLRKKIKPNRFNAWKFGLIAGVLVSTTKTFTTILFRNIQKYRKKSNKTTNPNSENTSTISQFFHPKNGSIFLREFLDKLFTDILYTSSYQSFREFHNFNLKPKLLPQNSSIAHRITVDIFLGSLSALEASVISKPFEVLIRQIYRRKKIDFKEIKKKTFSQILKKVPKSAIKVPLYGQAKLMLPQVYEFYIKKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBR3</accession>
    <name>A0A9Q0RBR3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBR3"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="394"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="488"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="593" mass="69059" checksum="4D25C85673B187CB" modified="2023-09-13" version="1">MNEIIFFGRNKQPKLFKNKPETITKPIQFKFENENENENENEKQIKQISSSFFSTIFLFKNGKAIEYLNRNPKPNPLEIQIENIQKVTVGFENEAILTIEGNVFAKGFNINKIDINEFINISSLIEDTNDRIIEDIVSGSQSIYLLTSNQNTYGIGSNQFGQLGFDSKTVIKSEKPILMMKNVSKMFSGNVSNHVFLLNSNQKLFVCGHNRYGQLGLGESRKESTTQKLTQIQNIPKGEIIDIQCGNFHSIMLIENENENENPKRKLYSCGSYGLNGLEKKGNTREFTEIKSSLFENDDNILDFSVGYNYNLILTSKPKLIGFGDNYWGQLGNGDTKDQSIPIQIELPKLRFNENISNYHVSCGNNRSFLYYSPPSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNENEKLQEIISNKSIQESNQIFEMIYSNRITNPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQVGIDYFQLNETNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCI7</accession>
    <name>A0A9Q0RCI7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCI7"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="67"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="418" mass="48154" checksum="2A780B08A353FFA1" modified="2023-09-13" version="1">MDLRFGEFTKEEIQNKLKISKIILPIDKILQREKKIKEKEERRIQRKIQNILPQITIQNEPIGIQIRGMENRGNSCFVNSVMQGLLACPPFIFFLDKIRKANFEDYSNCLILQSLAGFIKNISVDIDIKTKGFSRLGFDFDSKSTSFFYEKLFDVIGRFKPDGPNYLKSVQEDAQEFLNFLLDSVHEEIAVILGLNNSGKMFEIEKALQDFKNTQILVQRIIPKKTIIRDIFGGTLKSKIVPNGMKPLISFEPFMILPININGFHISSIEDALIDFSDPENLRDYTDETTKQNIGAQKKTKIHQLPVILILHLKRFRFSEKTGAFKVHKAINFPTKLTIPKKIISSELHKKGKKEHIYNLVSVIYHIGQSPIEGHYTCSALKWTGNWVHIDDTSISEVSEKEIVDPNAYILFYIKTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCY6</accession>
    <name>A0A9Q0RCY6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCY6"/>
    <dbReference type="OMA" id="LVGWWST"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="303" mass="34621" checksum="9583A1C995F01407" modified="2023-09-13" version="1">MTQIQSSSALEVMLHPLVLINITDHYTRAKLNEKKEPRVVGALLGTLVGRRVEIHNSFELVYDIVEKQLVIDTTYFVQKREQFSQVFPEYEFLGWYSSGKDIEQNDIVVHQTLLEFNDNPFYLLFDPKPAENIQELPITIFESELKIIDGSPKIFFVKTPFKIASNEAERLSIDHVAKFAGVSEKKESQLGAHLKTTHSAVKMLHTKLQVIIKYLGAVSSGKLKPNLAITRQCYSVINKLPAIDSQEFTNQFQKEFNDALLASYLVNITNGTNAINELVDKVEIAFETQRRGRSHPMREFMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDC8</accession>
    <name>A0A9Q0RDC8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDC8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="285" mass="31615" checksum="C63CB74627BA2860" modified="2023-09-13" version="1">MNLIQQLAWNSPLSNKIGVKSKGILDGFDYNQSMSVKSEIFKGVSFQMTSKLQKPKTVSSNVAVEFCQEFFNVFVKLLANYDTQKKENVTLTATYPFLNDFKLVVQAQHPKKATAQIEFNNKFLSTSLNHDIFSQITKISLGTAIKHFAIQTNGDCSLKTKKLSNLNFKSQIENDMFALELHANDFAKNLGGSLAAQICPLTSVALDANYLTDKKTWNAQLGVQRKVNDNLLIKSKVDKNALFQFNFSAKPLDNVKLNGSVGINCKSIKDLSSHSVGVSIDVQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REA0</accession>
    <name>A0A9Q0REA0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REA0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10325" checksum="5212B8AB29553A17" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RER6</accession>
    <name>A0A9Q0RER6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M0811_05329</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RER6"/>
    <dbReference type="OMA" id="FVPCEHT"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000026">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="162"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="314"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="627"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="688"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5078071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="831" mass="96310" checksum="DC84DD3F45160DB7" modified="2023-09-13" version="1">MDYISDYINLPNSNTQIYKEECTECFDTIDSEKGIDVCLTCFNGGCYTHNHSARHAIEYSHPFVLNIRRIKKEKEEKEEKEEKEEKITKVAIGIEGGFQEEKDEEKYEYFYAIRQWNKDGENYSYQEIEETSEKLKKTIESIKNFNSATKQEEIKEWEAQKFTCKHCEGLVQLEVNQDLIRNSKHCMECNLDHNLWLCLTCGHIACGRRNYDGSGGNEHAVLHYRQSGHPLVVKIGTITPDGDADVHCYACDAEVIDKNLPLHLIHLGIDVSDQKKTEKSIAEMELEQNLALDFENTLIKDGKKLTPISGPGLTGLRNLGNSCYMASSLQVLFSFNPFITRYYSGKLSKRENKQILINPADDFGAQMRKIAHGLLSGEYSTQIVLEDQKPEKELTSISPRMFKSLIGKNHPEFSTMLQQDSLDFLLYLLDQTKKQENKYKNQEKADPSISFNFTHQSKLQCNKCKRAKYQKLSSIHLPLNIPEYVVDKEEEYQISRENAKNETQKKEEKWNEEEWKKQNKIPEVSLKELLDNFIAVDTVELRCPICGDSFYSKSSSLITFPEILIVSINKFRLRKWVPHKMDININLPVDEEIDLEFLRAKTPPENEQLFEEDELGNEMKLTEKIPVADENIVSQLELFGFPKNRAEKAALTTQNASTEIALNWLLEHQDDPDIDVPFSFKEKQKDDFVDDPIIIEQLTSMGFSKEQSIFALRQTQNNPDRAVDYLFNHQDDIEMLMIQESTKKQEKSQDDVVFDDDENLCEIENENDKEKKHAKFVLSSFIVHMGSTPQSGHYVAYIKKNDKWILFNDSKVVIDDDPYFGTGYIYFFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFP0</accession>
    <name>A0A9Q0RFP0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Syntaxin-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFP0"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="276"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="427" mass="50206" checksum="DE595743538DD577" modified="2023-09-13" version="1">MSFKDYLIPENSEPDLLLVTEEQKKSRVIRFLNKFSDLFESIKNEKKMNEFLVKKLLIQDVIRDCETFFLENYYSEQEKNKESTDFDKEMDIYLQKFTKLKLQFLNYISNHIFNQENIQIKEISVDDSDSFQMLYLKEDEDEDEDEDEEQKKNNSNQIENQIENQNQNQLKNQIENQNQNQLKNQNQLKNENQNQNQNQIQNQNQNQLKNQNQNQLKNQNQNQNQIENQNQIQNQIQIENQNQNQNQNNDSNKIDIDFGNLQENLLIYENENKNENEKFEERKKEIEKLQPDLIELMELYKEVGVLINNQNENLKIVEKNINTTDNLIEEGKNELGKASFLKAASFPIIGAIIGGIFGGVGGSLAGFKTGSYLSGATFTGLGAWIGWGLRNVQKDSTHEILEEQNQNQNQIQNQNENKKEKENEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFW4</accession>
    <name>A0A9Q0RFW4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFW4"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="231" mass="25720" checksum="08C96A4B1247B175" modified="2023-09-13" version="1">MEEKDKNLENAIRQQDIKSIRKIIKEGANINFENEGWSPFLMAVEIGNLEIMKILAHYGANVNHRNNSSNALYIASQQGHTEIVQYLISHKANPNIQNKGATPLLIAAQEGHLGVVKELLKNKADPNIPDAKDTPLHYACSKDHYEIVIKLIKHKANLNAQDKGDAPIMLAAEKGSLRIVKLLLDAGASILKKNRNLSVFDLAANDEIKELLKSQLKKTKPGLFKKCFSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI24</accession>
    <name>A0A9Q0RI24_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000002">
        <property type="protein sequence ID" value="KAJ5080754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI24"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="530" mass="63469" checksum="BF699BE88B49A070" modified="2023-09-13" version="1">MSQVVFQLSELLEKQKDLETNYFKENEAIHKIWQEFKPEFEAFEIVQQMKKFAPLFIETYFDWRPIEEKTGISDFELLPDDFKYQRELNPEEIISAIENHSAHPLQLINFVISYDCFSYSLISHKVSNFKLDILNDMKENENENENENENENEKEKENQNENQNENEKEKENQIEKEKENENENQNQNQNEKEIKIEIETDPNLSQESNESIKMEKEKKFLQKAIQKYPQFTLKKTKNSFDISKEIDFNSLRSLQMISILSRSKYNRSILHSFNILEILVSYIKLITQITNIIQIQRKKKPELAVNNLFMVQFIHTQILDIISKFFKMNEVLPPREFLVEAKNQKLIESLLNCFEEMLKLKQSFLFTRKQYDLLLTHVDILENLTNFGIYTEEDQANIVKLLINFFKQPNLSLPNLGINQNENENENQNENQNENQNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNRNQNQNQNQNQNQNQNQNQNQNQNENENQNQNQNQNQNQNQNQNQNQNQNQNENENEKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4U2</accession>
    <name>A0A9Q0L4U2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4U2"/>
    <dbReference type="OrthoDB" id="148763at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="24541" checksum="F06044EAD1A9360E" modified="2023-09-13" version="1">MEFSNWNQIKIIGIFLCSIFSLTIYYFANKVSVQLLVFAHSILSSFSSIISLIFGFDPSYSISFTSVYFIFHTFYIHQEPCKLTEKITTYFHHLLGLGFGFPELILQKNGYVCLCFQANEVSNIFLSWYRWKKTNISGIFFAIAFFSTRVLWDTFYILPFLLPTASLYLKVLSVPLFTIQYIWLYKIIRKFTNFILKQKSKKEEKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5I9</accession>
    <name>A0A9Q0L5I9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fmrfamide receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000141">
        <property type="protein sequence ID" value="KAJ5066531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5I9"/>
    <dbReference type="OrthoDB" id="10059790at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="409" mass="49633" checksum="DEAA3CD0FD6485D3" modified="2023-09-13" version="1">MILVLELKKNINTSINPFVVSIYIEKCFNMVDHRIIRKVIKKFIVNIHLKKFLINYYKGNSCDIYKGDLLTLIIFAMWKKQKYCIRKNQNKTIISKKLYKIKYLGIILDPRKHIQHNFEKAKNNFTRLKNIMSLFINNHLKMKIYKTVIIPKIIYGTETLIFTQKEYHQIDTLINPQITQNLRINRHTPVKIYRNETNTPDSRTQINIRKWKLRKKLGDIDREYLQEFCIIDSNLQEKVYKIWGKEYLKYIQNYLLIQRLQDMKESKSWKTKEIFTKFNNPQTKIIHKRIKSIYLKHEKYFQNISILSKRRRKSQSLFMEKLESNESMKKHSSILKNIYKSDPNLQEKMRIENQIENQNQNQNQNQNQNQNQNQNQNQNQNENQNQNENQIENENQNQNQNENQNQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6F8</accession>
    <name>A0A9Q0L6F8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6F8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="370" mass="43349" checksum="0BFE68BA0B95A813" modified="2023-09-13" version="1">MSQEEEKTIPISLETHGNDNKVTIQIGEMPKENLQKKSNNLSHIKMFNLRPGKHIVKIWRTPKVGETSFYQKEIEVNKDSKNFLIDERRVDSDEDEDSGVSDDLGDSDDLGDSNDLGDSNDLGDSNEIKNEIQNKNEIQNENDNNDNQNDNQNDNQNQTLNRKSSSKREIRKERLTQSLELPTNPTSPSKNRKLETEKHPPLIKKLSFQDSARKIFSLSQNLKKTPQNFNSQDKETETNQNLNPQEKEKQKKEQDQDNQKKEQKEQKKNQNLNSQDKETETNQNFNPQEKEQKEQKTNQNLNSQDKETETNQDLNSQEKEKQKKEQDQDNQKKEQKEQKTNQNLNSQEKEQKQIKILIHKIKRNRNKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6Q5</accession>
    <name>A0A9Q0L6Q5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fanconi anemia group m protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HTRKDSH"/>
    <dbReference type="OrthoDB" id="19599at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1837"/>
            <end position="2606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3265"/>
            <end position="3304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2787"/>
            <end position="2814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1837"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1854"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1867"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1900"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1911"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1932"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2045"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2056"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2077"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2157"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2178"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2333"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2354"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2455"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2476"/>
            <end position="2491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2492"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2507"/>
            <end position="2557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2565"/>
            <end position="2578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2586"/>
            <end position="2606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3269"/>
            <end position="3280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3281"/>
            <end position="3291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3292"/>
            <end position="3303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3589" mass="429633" checksum="E717B3F39471B197" modified="2023-09-13" version="1">MIVKYKENQENQENQFIFKFLSHFKFKDEFITIFFNENWRKKQPLKEINKIVEIYQTINSLSEKFKTLESNFSNHFSQLFEIFINFPNDEKFIIFLNSTKCRRSLEKFLKQKREQMKKFLYKTTPFKSFEKLIDLAISSISKEIEKEKEKEIDYQEVEKFLSKFSSFKMKKISTEQKILNNLALIFGKESSNYHFIYLSNEKVGFLYQNEKQKQEKSLNFKDFLEINIFYDNIISKKEYKKELEIFKTNFSKIEKITEISIKLKNLHFVQIPKDSSKKHKSSLTDFQSKLDNFEKELSLNLSEWEKIIKFPQSFQISFFSQEQFSSIIEGYFSKKKEDESNSLSLLSSFYPNFNSKKFGKLFTSSSKKEKNLTKLKNFIQNISKLSIKDSIKKRTKEISIPSAKINKKDIPKKNKKITQILEGNKEIQPLNISFCKIPKEKKVYKIVTSLYFVYCNHFPLKENVLICNQENTMINDIEKFFSIYQIYNQIYEENDDKQKYIFTIIHSHKLNPECLNFLNKKIQEISYKIHFPLVIFYYENYIGSFSIINHFQKSLISYKDFVIPQNFIDHIIFKTKLHENLQIFSSDFPGMGKKKFSYHNFVISNGTTKEFIDTIYSIINSHKNYFKFIHIELPFSIKLETLDYLWTLSMWDSIESKRKLSQNFNWIFDSSSYFLALEVSSKKETKISSQFDHFPLLYFFERNEMEVDSEIFSLNKYHLNNFNIEEKKDEKWKSIESFFNSFKDYLQDSNITKSDKKQFKLKLFTFLKNKISEKLVDENLTFRLFSNLIVILKSQNELLSNFINIIKSGKQQEQQLFIESLLKVYFSSIINIISSFLHWNQKEEEYNYSNESEHFWKILSNKIKWNDKQLSIPLFLQNNDSKNEKLRTLFINLIDIFLKEVSNIFLSFNPTNSQLLNIFSNFPEKFNNGEYPFFIQESNIIKMIYIIFKLSLNIPVIFIDGDEIETKLIIQYLLKNIFNQKLIIYYVNSQTTQEDIIEVIEKAKQFIKKDSKPTINIWFHNFNCSSKECIILFKKILLDRVIKQESIPENIHFLASFKSAFSSNIPQDQNNNNNNLISLPQIIPESFFQDLYDFGNSPSLDELKIIQAILLQNISKPIPEFIFLHYQIQELSQIIFYSRKHIKKHSTFPNEYFESYQDVSIFTRVFQWLICNPIGEIFITNENTLSEKVYLTFSLCFFLVYFYYLDGEKRDSLLSKMNRKIKLFNIEENFNTIISNLFNFLEIDLSKNDIVKNKILKENILFILVSCFSQIPLLIIGKPGTSKTISLEIIFDLFKFNPNQKPKLQKMKIPYLKKIEIISSELISKEYLQKFQDGMTKFTKKSKRFLYSQIQTILNEKYNFPNENLLPFPSIILLSNSFVDFPFCGFVLNHQYFNFKEFELTIEELLIQFPDEISGFLKEQISYIFSNQEKIISKQFPQIIQNQKLETNFYDVRDVYAFIRDFKSIYSESDESAYLFNEKQNRLESAKSLRHILLSIQDASFFTILYDKFFHDNSTVISSSKIFSTLKKSKEDELKEKLMIVEFCITNGKKLIIFDYPEIYPFLYKLFNQNYIQKDGDILVTISFGEESRKIIINPNFRLFVITTNGINYEFSNSAIRNHFGKYNIDDSFFEIKKSKQLKKLEKFMKVYESKNGNNELIFGFNQTFFNSLISKYQEKNSQKSKKESEQKIKRKLVEFFKLKRVMQIRSSIPKEENSNDNQSLNEILNDYQEKDSYVNFDHFFENEIEKNKIKKSIIFTNSKENGIENSKKNLNERSVLIDFRNGNKNNKNKLEDISKVDQKRNILMIHFEQEQISEFYEMKFFIETIEYEYSKPKIEMENQDEEKDKDNKDKSKSKSKSKSKSKSKSKSKDKEKDKEKDNKDKDKNKDKDKNKDNKDKNKDKNKHTHKHQSKSRDGSEPSHTRKDSHTRHKSKDKDNKDNKDNKDNKDNKEKDKDKDNKDKDNKDKDKDKNKEKDNKDNKDNKDKDKDKDKDKDKDKDKDKDKDKDKNKDKDKDKDKNKDKDKDKNKDKDKDKDKNKDKDKDKNKDKNKHTHKHQSKSRDGSEPSHTRKDSHTRHKSKDKDNKDNKDNKDKKDKDKDKDKDKDKDNKDKDNKDKEKDNKDNKDNKDNKDKDKDKNKDKDKDKDKNKDKDKHTHKHQSKSRDGSEPSHTRKDSHTRHKSKDKDNKDKDNKDKEKDKDNKDKDNKDNKDKDNKDKEKNKDKDKDKDKDKDKDKDKDKDKDKDKNKDKDKDKDKDKDKDKDKDKEKDKDKDKEKDKDNKDKDKDKNKDKNKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKHTHKHQSKSRDGSEPSHTRKDSHTRHKSKDKDKNKDKNKDKDKDKDKDKDKEKEKEKDKDKDKDKEKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKNKDKDKNKDKDKDNKDKNKDKDKHTHKHQSKSRDGSEPSHTRKDSHTRHKSKDKDNKEKDKDKDKSKSKSKSKSKSKSKSKSKPKDKEKEKEKEKEKDKDKDKDKDKDKDKDKDKNKDKDKNKDKDKNKDKDKHTHKHQSKSRDGSEPSHTRKDSHTRHKSKDKDNKEKDKEKDKEKDKEKDKDKKFTPEYVIFVIHLSQNNKFDNFPFCFEKDSEHYYIEELYPKINLEFLLTPNLTLKNIYEKLIYQKLHDENLIDPKNLFQQIAGISLSRNTDFKQENYKFLKEILEKNLQNEKFVKIVSEKIAEMIDIGCKAGYLSYKFDADYIISQEVDMPLSYYVFQNFIEKLIEFFGIFLKNINQNQFLSLLKKQNENENENENENENENENLLDFLDKLKIPCYEITDNDDKTMDLNPFFFFIYSQIEKSESILDETIFDFPLINAQMNDKNYSEIFKKHDLPNKYLIFLTRFTISSEEEQTIFDSIEINLSEWIQKIQRKKPNEVFELLSLKDIHLIYFQKIDKNLSHLLKILSISKISFKKKSFSLVAFLDKLIKKLYANKDDQKSLFKESMKTEELFKFILEIGDEKDLEKIENSYEKWHIKLFQNKFNIKLTNLTSDENNNEQIYEEIEKGMMIDRLGTDLLKKLFANKVNCQDIWICKESQKSQKSQKSLYLINDINEEKYQDNKGKKCPICKSKVEDFSGHFVKARKKRIENYREDLRNLIIRFAQCLSFYGKLIAPKFISKKKMIKGFINYLKKKKDIFFKVDLVNIYESIFVSFFKDLFTLNQEEDMINFIDRLLRSTNRKLENNGSDMILRSCMRILNENDDLVENLQEYINEPNIQKQKDEKEKDEKKTKKSHSKKRNSQSKNSNQDSLDSIDQSQESSKFELFDNNYSFAKIMNFILKREYYIQNPRQFIKQIQKTLSKEDRELWLKLIFSAVEKNIGKSNIQLLIPKLPRFIQRSEFLTTMSEHKQKEFSLKISSNKKTKSLKYYYKKKQLGEDLKVDFNETHISFASEFNTSYIVSKLYKNFWEIEKNFDDKLLFRLAIESAEFLSSLKIELFEYLFSSDLLFEIGEPELKIQRLSTLYWPSMGTHPFREEYKKNPDFWMFCQNGHLNFIKFSKLRLQNHCEFCQGDMKEQKIENEFLMKFCLIQLENFLIQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7L0</accession>
    <name>A0A9Q0L7L0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_13119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000131">
        <property type="protein sequence ID" value="KAJ5067249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7L0"/>
    <dbReference type="OMA" id="NFQDDIY"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="8">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="449" mass="49880" checksum="F423CDA974937133" modified="2023-09-13" version="1">MNIVRRSKYRHVFGTEAKRENCFDGIQATKTAWDGNFVAANTKFVAACWASGGGGAFAVLPLTSVGKLGVIPLVKGHTGKVLDLAFNPFNPNLIGSSSEDCTAKIWNIPDEGLKEDMKESVQNLNGHKRKVGHIVFHPSANNVVSTTSADYTVKIWDIEKGEEKITTTGPSNIIQSFSWNMDGSQFAISAKDKKLRIYDPRADTSPIAETEAHTGVKGFRVVWLTDKDKIFTVGFSRTSDRQFAIWDPREMEKPLSTMNIDTSSGVIMPFYDPDTSVLYLAGKGDGNIRYYEMIDEPPYYYALSEFKSSVPTHGMAMAPKLACDVNSCEIARAYKMANNMIQPIPFVVPRKSDFFQDDIFPPTFGMEPGMTADEWFEGGNNLPEKISLEGGFVQPEIKAEFKPEKQTDTPTLEITDPVLLREKLEKAEKTIKAQEKRIADLEAALKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L808</accession>
    <name>A0A9Q0L808_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L808"/>
    <dbReference type="OMA" id="ECEHAIF"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5068042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="194" mass="22892" checksum="D58AC14C43AE746B" modified="2023-09-13" version="1">MFSFFFGQEEINDKLSVKKCEEQVEKCVIHNKWIQKAIQFLTECSNKIEDISSESKKIINCKFCEPSLFPHSRAYYRIDEKKIYLCANRLSINDVFVVLKHELTHFIDDKLGFDFLVPEIVACSEIRAAKNAECEHAIFKKKCTKKFAYDSIKFKYPNQSHEIIERIFDKCYNSKIFLKDNISFLSSFGFNNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8H4</accession>
    <name>A0A9Q0L8H4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8H4"/>
    <dbReference type="OrthoDB" id="7956040at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="58164" checksum="D7E565A042FEA4AD" modified="2023-09-13" version="1">MNNSTNSFQEILESIQKTGKFSDVKIVVGEEKKIFQSHQLILAVNSLYFKKLFYGASWKEVHDKKIPEIELPGIESSIFQLILTFIYTRKIEFFDSQVLFKILQAADYLLIDSLKEKCEQILLENLDHENFFSLFFLAKVYELKQLEKEIKKIFESRFDFFQTEKIPSDLSVFEMKRILEISLFMAPEIEIWKFFLNWWKNFAKKKDEDLKMLLKLIRFDIMNEKELGIVMESNIIPEHFFDNFKKRENINDWQNVSRRRTKKLSDDEIKVLITAADDSTEYINETIRFVKNNSIKNVDSLVVRNELPSLETMCNYDVIYTYSRFSQYKDPKIWGNRLVEYLKNGGNIVISSRNSLRLDSQYHLKGKIAKNKYLPLTISKSVTHRKSYLSKFDENHPLMENVRTFDGGIGSFHVSGVPTEDTTVVAWWDDDSPLVSFKRVPLKGVVVALNMFAVSDEVGPNCWDIKTDGGFLISNTVRFAANYFFYENKDYLQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L912</accession>
    <name>A0A9Q0L912_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L912"/>
    <dbReference type="OMA" id="RIDCNGP"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38886" checksum="2E0515F3E5DA8ACF" modified="2023-09-13" version="1">MLQNEILCYWNLLETNQQPRGTTSCAFARSENKLIIVGGNSQRISYNDTYSFDLETHQWDKIKTSGEFLSVRIGHTISLYNNSVWLFGGYDGEMRNDIFILDLKTHIWRKLPQPKVVPKARLGHTSVVFEDTMIIFGGWNSNAFLDDLWQFSFKDKTWKELETTGKAPTSRNGHHSVMISSYEMVIFGGRNEKFERINDLYILDLKKMEWTEILALNEKPKGRAGGSLIQIDDSNLLVFGGKSEPYEFLSDCWIFNLISRCWTKLEPLGFEPRGRAGHCHIYDSDSRSLFVFGGGRILEENKDDYFWETLQLKFEKDIVEDFWNFLNLKQLCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA60</accession>
    <name>A0A9Q0LA60_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA60"/>
    <dbReference type="OMA" id="TGENHNP"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="106" mass="12930" checksum="82E4C07E94BB53DE" modified="2023-09-13" version="1">MIQKKLELELELELELELKLKLKLKLELELKLELELEFELELELELELELELGLEFELELKLKSEFELELEFKFGLEFELELELKLELKLEFELELKLELELKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAL1</accession>
    <name>A0A9Q0LAL1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAL1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="268"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="70428" checksum="645B467873FA7484" modified="2023-09-13" version="1">MKSNQMKLNEVFVLIQNRIIKPFKFKNEIEIENENENENENENENEIKQILSGNFSTIFLFKNGKAIEYLPKDQYNRKPRKIIKIQIEENIQKVTVGSGIKAVLTKEGNVFAKGEYINPKNPNEFINISSLIEDINDRKIQDIVSGCSLYLLTSNQNVYGIGSNGYGQLGSKTILKTKKPILMMKNVYKIFSGNSSHYVFLLNLNQELFGCGYNYSGQLGLGESKKEEENKQFAELTKIQNIPKGKIIDIQCGFVHSIMLIEIENPKRKLYSCGNYQYNGLGKKENTYEFTEIKSSLFENDNILEISIGNSHTLILTSNCKLIAFKNRGSELDISITEQQLIPIQIELPKLRFKEDISNYHISCGYPKSFLYYSLPPFSNLEEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLKDENEIEKLKEIISTKSIKESNQIFEMIYSNNSIINPNLYSDIKEIINLNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNGIQITQEIINEIKTGIDYFQLNQTNPNLFDLLINKFNNQNQNQNQNENEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBE4</accession>
    <name>A0A9Q0LBE4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron carrier/ protein disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBE4"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="443"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="858" mass="99841" checksum="8E969BCA4CE79E16" modified="2023-09-13" version="1">MGNIKTFAKQIPKNQTKQFKQTLQESTNAVVLLKQTGVFEFASEAAIKMFGAKSRKELSKQTFLNTLVIFQNHIQLPSQRVVDMVVLRAQENKGQISLDLQCRTLSGTSFWAHIKFEIIQLGSNTVFYLELQPADEPPKETFIALDLDFESKLQSENQSQEIQTLKHQIKKLKFEIQTLKSQDLSGSLQMKLGGAQQRFNDKVKENDLLSIDLEKITKEIKSYNEGAPKIIEELKVTEQTIKDLNSSIESVKNEIKQLKEDKKNEEKRNKIAELEKEFEQRKVDQELFQKQLTDSNDFLENISKIPENNETSREEEIKEIENSLEQVKEQVMEGQEWNLFEKNRDPQSQHIIEKRLKTLKNQIKQKAFENRQLLAEIEQYKQNVKTDGTNNQTQTSDALVSNSERDGEFSDISERAHSQESLKRYQSVQVTDSALEKFDENEVFNNLLVKPEILQIFKEFLCENFKQESLLFYLEVEKFRKITEVEKLKTAANEIYVKFIKTESLFEINIKKKLREEIEMLITKEAITRGMFDQSQEKMKKMIYETFIYALKISRNLFRTVNNPKEQYQPKVMKKATLLSKPRNETALNISIKFKGEIEGACLLSQELVNSVIDLFSSFYSISTEQIDFVKLSQSVVFSRFVNSTIKLQKVDLALLSEEERKSFFINIYNVLLSQSAITNGISNDKAQITRFMTENRYKIGQNFFSLLDIRDGILRNNQSHSNKQKIIPHFESGDIRTKYSIPLDPRIHFAISGFNIHSPPMRAYDPNSINQELENSTKQYIEKHMKISHKTKKALLPYIFQLFASDFGSSPKNELEWISKFYQSAEENEPLNTYEAKFLPQTFHPMVIFDTSSNIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBV5</accession>
    <name>A0A9Q0LBV5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040248233" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1735"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1768" mass="199594" checksum="5EFB8135923F38F3" modified="2023-09-13" version="1">MKKLLFFFGFLFFISFIKSELTLNQELYFPEGTQYLTYSFVDAPNQLVYFVDDLWSMIEYTLEGKLYKFNMSTLELIDSLDLGIWGVGCGIFDNENNLAYFGSYDSPSRISKVDLNTFQVVGVLTLSTDSDGFESAQIDIENQKAYFLLSYPTQVIKIDLNTFQQEGDPLELNDEDSWGLVIDLENNILYVSGETENEDGYYSLIFKINLTDFTIIADLDLSEYDVYGACQGFLGVSKEFLYFGNYDYPFLVVKIDVETFSYDDALELEDYAWCVAAAIDENENIGYFVTEDPAIVRVDLDSFSFIDGEYLDGYSYSSTASFDFQYNYSFIPLAYAEIIKFDLTEFQQETEFLEPLFIRAQYILLDELNQTIYLLFESVEYMIIAKVDIESFQMIDYVILDYYDDIYVGDIDIQNGFLYYFIDDSGLLILKVDMFNLTNMEYVSILPSGYVDDAVYNPNNNILYVSYYFDLAEIPLFVILSCPDLNILLAIYIEGEIYNFQFDYSTGYIYSYFEYWETEEEEYYLIKINPSNLDIEDYINITSYDISTMSLDQANQRMYFGTEIELIKNQEEKLEDSMFSEICSIDLYYMEMISCQEISGVYYFTDSFIDGDGNFGFFFTEFYDYEIEEPITAVFQLDLIQDTIELDVLDEYFGWPFGIFDPTTNFYYLTAWRNYPVPLAQFSIEEPLVPKVRLLGCNSLFSKFECYWFKIENDEQLQYQINYGFNWTIIEDPVLIDVFDIRYQEFNSSFYPNITGNEEYLIQIRACNLTLNECGKPSSIYDLITRIDSVKNYDLDGYYDYIDIFWDYPDVEIIEGIPNLDHYEVSIQKETDPPSTISIDDPSATSFQVDELEFGYTYYVSMWACSTEECEDEYEEKGEVVSSSISTGFPNVNSFNCVVSDVLVIDCSWLKPSTSGTPSYYTFTYEATTKEDSDTYYPNSTNQSFRANFQVEEYKINVSGCNSNDFCGLISTVNVTTERLQPPLIKQSISQIEEIKLIFTELTQGRNYLISSNNGTNWQNFTTLYSNETDMIGTLSPLSGNYEYLVSIRGCTDSSCGVDYLGLPTSPISISPKLGNVMITCVPLLYGFYCDWEPLELSIGLRGYSLSFNSSSKCLSIFETSYSKTELFGGANYEISIFASADSNCNYNEYSGTNTTLSITTSRLPPPLINQSISKIEEIEIIFTPQYQEKIKDYLVSINNGIDWQKFTTIQSNGNEMIGTISPLAGNVKYIVSIKTCTDPNCESEYLGLASSPVSITPKLGNISSFNCNATICGFDCDWEALELSTGLKGYSLSYNSTPICLPPSTTSYSVVDKLFGGANYEISIFASADSNCNYNEYSGLASTLSLTTLPLSAPTINQSISKIEEIEIIFTKLTLAKTYLVSINNGIDWQKFTTIQSNGNEMIGTISPLAGNVEYLVSIRGCTDTNCKSGYLGLASSPIPITPKLGNISSFNCNPISCGFDCDWEALELSTGLKGYSLSFNSTPICLPPSTTNYPFDSLIGKANYEISIFASADSNCNYNEYSGLASTLSLKTLPLSAPTINQSISKIEEIEIIFTKLTQAETYLVSIDNRINWQNFTTIQSNGNEMIGTIKPLAGNVEYLVSIRGCTDSSCETQSLGLASSPVSITPKLGNMSSINCNATICGFECDWEALELSTGLKGYSLSYNSINVCLSAAMTSYSVFNLLGDTYYQISIFASADWRCEESDLSGLPIYTSVTTLPAPVETASDSSKDKVISLSVVVPVVVIALIVVLVILIRKSKKNKKENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBW4</accession>
    <name>A0A9Q0LBW4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBW4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="69" mass="8491" checksum="6930B05363C2B86C" modified="2023-09-13" version="1">MFLNVQDSSNKVHDYSNKSFETIHQLIYFFYHDEFEKEHIRKNNIDELQDAKDYYQLNENSIIDLFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC84</accession>
    <name>A0A9Q0LC84_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Import inner membrane translocase subunit tim23-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC84"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="22181" checksum="C4D58D8201E92DE4" modified="2023-09-13" version="1">MEELQKIFQLIQQKAKIIYEEFKKSDWDDDFKLIGKHYFAGIGFGILEGTRKTFLTNQVKKGVFLDHTFESCLHFSQKLAGLSFIYLLIKNTIEKQRGIKDEYNHIVAGAGTGILYKTFTSKSSTSKLFGAAFGALTGYLIARKDEINWNNLPSEFKKVYSKTSSYLKDFNSKLNLNLNLKDLNQQKQIPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCD3</accession>
    <name>A0A9Q0LCD3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="2558"/>
            <end position="2664"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="2680"/>
            <end position="2967"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3185"/>
            <end position="3217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3231"/>
            <end position="3272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1980"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2052"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3050"/>
            <end position="3108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1403"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2007"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3060"/>
            <end position="3108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3398" mass="396840" checksum="E96B25BAE70EE219" modified="2023-09-13" version="1">MKKNKKNKRTISQSSDYFEDFTPNGNRLQTLWNNCFLIKNETEETEKKGINELTKDYIQFARLFLVSYRNWNPNDNLELEENTNKNMKFIDRMYKPKEINDAIKQKQAHPPKLIENTIEILQLAQNQLEYLTKNLKNQETLKLNLESLISLEVSSILSRSKYNRQMLFNFRLLESLINLIKMMDTLLQYISSLSNFSNEKTNNLLLVQFVISNSLIILNRFLKFRGKLIDENLKKLIIQNELIKNLLNCYKENMNLQKKFLLTNKHYELQLALLDNQESQPYILLNQMEDIYQANYFNFYQEPQQDISLLESNQMINDNLQAQEFAANHIEFQLRTYSISFLIQILTTKFFSRKFFTDENLSLITDFILWTAFTFPSNFGDQIPSKTKQIEKPIEKQEKEEVIAKQKELTITTTTEQQSENDPIKFKLIGNDSFPTFSFHTFDPKEQKEKKDNISFSNPYLDQLFKLLREFIDVDEKLKHQFQTTRKKKSTRTKSGSKDKQKNNKNNENPKKKMFSKFRKKKKNGDINENENENQNQNQNQNQNENQNENNLYFIYKRKIIHVCMNLFEDDFNNSKENQKARHFIKNVIPELQFYVMFLLEKNMDNNTLNFLRQENKWKTIFTDFFIHRPINKNLPQFLQTLFHYLFNKSRDFFSNIILKNQDNFEYQFLFNQLTQNRDNLFLLFFCTKVYIKIFKSDMQSTVVKFIDNLGFKIFNILLPFLMDLYSTTIIHYPEKMQILHKLTHSMLKLLHLFLSVNETQLFVFKETSFMNLLIILAREPQTRSLILPHLKAILKRTEKQENNQQNFLISRIVEEMLLLNQMSKNNSVEVSTNVDKMIKELVAVAIEVINFIPDVLQPQFVLANIFSTAMTLLFSHQSNQGNEYIILELLAALFRNSTSSLDFFKKSIGYSTFGELLCDAVGENPDQKIFEVLFNMLVNNGEFDIQNNFTIQNPDMILIIFRVYTAGLRNSLVENKQKNSNTKIENQQDIKKQQNEKLSNLLDIFCQICEKSLHNTSSCGDLGLVGYLLKLISQIVDFIEIENENEQLAEKMIRLVLVIGSHRFSVSEMKKIFQMVNMFILQNKAHKITELLIDGVRSTIQKTKTQNGPLYFFDFNGRNSRIEFSMQEKWRATKGFTFLTWIRIESFKSPTQNKQNLPNIFSFFTSSDYGMQFYLSENQQKAENQEKHTLYYSVYTSKHWDKLSANFTFEMKRWYCVAVTHSNQRWSSNGPAEIFIDGVSIANKTLKFPSINESFTKCSIGFKHTSPKSPQKSFNYLFYGQMGTLYFFDDSLEPEWISGIYHLGAEYNSFFESNEMEQILKKNQSSYHSLIRNVLDGSLTSHLMICLNSKASNGSVCFDQSPKKQAISGSAKLVSISQCSVSNILHLISCFGGTKMLLEMMLLISSEQNENQNENLNQIQNENQIQIQTRKNPLIFEKIFALLTEILLGNPLNKQDFHTEHSLCTLSSVLKRIPHIFITSGVLDHLRRLIFDEATESSDFIADLIAGIMLDFDIWIRTEQGIQEQVLQIIHELAEKSNRENPNDRFKDITTESLVDVLRRYYWSGSAPKEIRAWTPTKTPEPPTPRYPEQMGNKSWQKLQNMANLPNEQKHQLAQKLLSTIVLCIKKAACDTEMFNKEIIFLSITCCLSNDLALNNELLLVLFQIFTSIPTEQQFHLNYLNIMDTLIYLMEKNNEAAHINLCLRLLFLLESAHVASQGKKKKIISRTRICSSCEYNVLHMILVETSYTEVLPTLFSLLTCNETQQNDPTIGGRTIQNCFILRTITSIISEHPNEYSLEVLRNVRFLITENVVNKELLLIEFMWQRLLLQIIDSSIPVDFGTIPQISKSHGSQFQINNVAFAILSDILLYCMFNKESFGSLFEETAALINLSFLSQQNAQRIVLRILSEIISATTTLFEKRFHDEDPTNIQSELKRSNDLSIVVENLYHLINMVCYYHFLSPLQNTPNILIQNENQYTNSQFNENTKKPKKDTKDKNKNKNKKNKNKKDQKDQKDQKDCEKNQCSLEQQQQQQKAGKPKILIRTVSTVFSKPKKQKDFQENSAFSSTKKKRGDTENPTVIPSHFRPIPISTSQPMIPSFLKDTTNIISEETNQMVNMRKITNKALMLLYSLLDSCSFFDKKGIKLHDKTSTRAIYKMVLLSILDSIDSFEGLENEKNLMFLARLFQGPLKITSRSLSKNPEPMMLTLCYLFRILESYQRDLHQENNTEQDLEKNPKILQIATIFQILMRDGYSFLFETLCDSHENSDLVPRKKSKESFIEHRNISQFIRSLFDSKWKDIFQTKFSIIESKIDLEISQNQELFSQVLFKNTQLTKIRVSENTKEDLLLSEKFRIEIDKNVNTMMSIETRRRANKREGDQKKARFAQLNYHRLTKKIVTHHKIKTQNQSGQHWKLDKIEDHLRCRRRMKIEYNFSQYPDSSVHQDSSLTNNAERKIDELNLQISQIDDKNAQNRNIKDLNEVFGDSSTISEIDSDDGNEDIDDQEIADNMDYSEMHMNDLNDLNDFNDFSESKRNSISHENKPSHFGSIKLKDIFLRRKTISIPTTARYTCHLILPLSRTPGIFEVTNSHISFYVDEKRIEENPNLYRKEDIHNKDYNWSVSSIIGLHKRRYIYSHCAIEIFLNTKKNFFLTFEADLRDKIFAQITTHKSLGLPSTPANFVTSPRSFLKKTRLTRKWKRRKISNFEYLMCLNTLSGRTYNDLSQYPVFPWILCDYNSPEIDLNDPNIYRDLSKPIGALSKNILPMLNERYNSFPKGTPAFHHGTHYSNPGIVLNYMVRVYPFTSLAIKFQGGKFDKPDRMFSSIPNTWEDLMRNNADVKELIPEFFYLPEMFENCNKINLGKKQNNEEVGDVLLPPWAHSSQEFVRIHREALESEYVSLHLSEWIDLIFGYKQTGEEAIKSYNVFHYISYENCVDLSKVDPSDISSVQSQIEYYGQTPIKLFRKPHPKRLPQTQIQKELSFWNPSKIRESFKYFTFHVSDNSLVFLGFSEFSPNFVTTNLNGRIWVFDESRKLMEHRFIISRNQSIDQKLNQNEKQNENQNEKQNQNEKQNQNEKQNQNQNQNQNQNQNQNQNQNQNKNQNQNQNQNQNQYQNQLEKENLDQNRIISLDIDTSKNSPQIGVSFSKEIKNISNCFKLSSNSKFFISCGYWDDSLKIFHLESSKLTDTIHMHKNIVTCTAVEKNILVTGSLDTTIIVWEFDYIQGKVNETPNCILSSHDSEVVCLDVNIDLDLIVGGLSDGSVVVYSLRKGKHIRTIYLSTTTTTKTSQSQYITLVKICTQGYLVVYTFEDLTIHLFSLNGKHLVSSSCPQIVYSWAFAKNHPFFVLGGKSGMLQIRELYSLKILFSADMKTAIRSVALSPNERWIFGANGNGDVICCGFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCW5</accession>
    <name>A0A9Q0LCW5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-y-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCW5"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="325" mass="38091" checksum="CB67C27F5B60F36D" modified="2023-09-13" version="1">MSICVDSLRDTFLCDSDEEETETIISSDDDNDLHVDHVVDHTFIDIVDNFSNSKKQEKHSFQFPILTFSESEDEDDNKKMLSNRHKQTVKLLFKKSQNKPHYELQKLENRRNSTSTLFVDNTLTSPDIYLVVECLSKAILCYIKNEKEKENEKDPFLIFNEEIHPISRNPPKSFYIPNENFIQRFFAAIFKGANLSPEILVIMLVYIERLIQNTKIIINPKNWRRVCISALVLATKEQTLLNLIDYNVLVTASVYAKYYFELRALSEFDNKIFPLAPLDKEEQERLESRSLLTEQKKKFFRNKKDFSSDSKLDVKKNSPAFIKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD16</accession>
    <name>A0A9Q0LD16_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD16"/>
    <dbReference type="OrthoDB" id="2376984at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="65364" checksum="C1B4C376BACC6440" modified="2023-09-13" version="1">MSSYTSLFKRLLPIGGVRSLKVREIEKTLGKNVAISETSEDDLKEEKKKEKDQNLNEIELETDSQNENENENQNENQNENEKPEKKSEDKNRFQLTETEIRLILRRSTRRYGTQNILGAFSQIQNDEKEEKRRRKRRKRRKKSKLLASFWLWVVLVALLILFCTKLFRSACLSIQLYRQQIIGDLQQGSCFNDRPDISDYPETVSVYAIQLINQFSDYCPIDQKPLENSFKNFMYRFSRYQVNKIMNAISVVTGISAFIAFIILLLLWRSIFNLYRKRIMLLRQGKKPFNDFDQAKTVLVTSYTNLQIWLGLISFLVVWIIVFIILFLIPALYWFVSKDFVVKVITVIIIFLAIVFVYQIIFGIVIQKIMNKYFVDKEQITNRTAFSIYDFIKFFMTVFSGATSAVKKLLGTTGGSVSTIFRLDDEKSIDESYSAMMLIDHQTNNPILRVFANYLMNLLKHQKQMIRHITEKKPDISEKEISMAVSYLENHPITGEPFEIEKIRKKYLFLLTIAANKKIQELRKNVIETERKRKEFLKQKEDKIWETIKNAKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDE8</accession>
    <name>A0A9Q0LDE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDE8"/>
    <dbReference type="OMA" id="NTHLACD"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="198" mass="22641" checksum="8017FF3C3992B91B" modified="2023-09-13" version="1">MLKGNNLLHCACLVGIKIDVIEFLIACGININQSNQRTPLHIAIKYQTNNIEILSLLLSSGADVNCKTNETPLHYACRKKANEDVFKLLFSYNADIHVKKGMTALHFCCRYNRDKKFIQLLIDEGSLINEPNGWTPLHFACFYNDNNTDSIKLLIKNGADINYKNEEIPLNYLNSNLLKDIQTFIEEMKEKTSKKMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDP3</accession>
    <name>A0A9Q0LDP3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDP3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="385"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="565" mass="67524" checksum="25FDF6959C941E1E" modified="2023-09-13" version="1">MDNNNNNQIENQNQNQNENEMKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLFISLNQFNKKEMESILSYIYYGNISFENQENLFQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNIWIKKRVNSLKLKKYENKMNAKKRLFHSFSSLFDKDSISKQDFDKLKQFDFFLPKSFFIKKQKKLIQENKIQEKKIQEKEKKIKRRDKRIKERDKRIKSFESEIRNLKSENKKKEKEIENKEKENQEIEEKWKKEVENKNKENKEMKPIFDKYRDQYQMEIIKQIFSDSEIVKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFDSQNWHKAVDGKGKTLVIIKTKQNFIFGGFTQVGFKNVQSGGEWINDPNAFIFSLRNDKGDRIPAKFTAKEGSAIYSNLSCGPIFGKPNAANDFYLKSSLQPGYSNFGYGYNLPNGITYNTYQAQSYLAGSYDKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDX5</accession>
    <name>A0A9Q0LDX5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Elks/rab6-interacting/cast protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDX5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="301" mass="34818" checksum="FEB0DD6E69D5C01F" modified="2023-09-13" version="1">MGNANNAKHKVTKSTLKKYKKKIYSSKDAVMVTIVGKSCVEANDAAVEMFEASSRDELIKFQPELLSPKFQSHLNKTTQEVIMEGWKKISESAEGYLDLVFEHVSIKGNHFFVHVWVTAINFLGQLAAQSVLKKVQKPNPAEKKIESISDVDTSLIKPKFDDESSDTLFDSQSETNLKSEKQTSNGALAKDNLDKEIQRLDKELEKGMKEKARLERIKFKVLEKQLNEKIQENTQLKNEIFVIQQLLDEMKKSNQNENESQFQEEIERIKEKKKKFKTEVERLTNRLKMVEFEKENLKKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEB9</accession>
    <name>A0A9Q0LEB9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_11465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEB9"/>
    <dbReference type="OMA" id="PWRWYNL"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="13">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5069953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="259" mass="29953" checksum="F2782DF90415B9AC" modified="2023-09-13" version="1">MEFGIYHEVQKDDALCAAHCLNSLLQGQYFSAGELTEIAETLDELERQTMAQNGIDSVDFLKFMAQDSKNVDLSGNFSVQVLIKALEAFNISLIPLFHPSEKNSRENPHLQNAFIANYMSHWFTIRKFGGSIWFNLNSLFKEPEYVSSTFLSLLLSQLQQEGYTIFVVKGILPESKADQFLEGLTELPNYKKYQKPKQKPKIEKMKKKDSIEINPILKETIEKSKREMINKEEFDEQQQMELAIQLSLLEINKEEKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEJ3</accession>
    <name>A0A9Q0LEJ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEJ3"/>
    <dbReference type="OMA" id="ASKYSYW"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF60">
        <property type="entry name" value="COUNTIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040165508" evidence="3">
        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="4">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="138" mass="15004" checksum="8B6B7E24B425606B" modified="2023-09-13" version="1">MKVILFFLLIVAAFADIWTDCSQAGDDFKITDVVITPNPPVKGQPMTAEIKGALSKTITGGTAELMVYYNGIKLLDITKDICTIDPDLPCPINANPSVDLKFTETIPSYVPSGKYTGQAVMKDQDGKEIVCVKFDLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF95</accession>
    <name>A0A9Q0LF95_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_10427</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF95"/>
    <dbReference type="OMA" id="RTIVECM"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000011">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="13">
        <location>
            <begin position="617"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="14">
        <location>
            <begin position="756"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5071365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="872" mass="99608" checksum="2F3B4029AED21DFE" modified="2023-09-13" version="1">MQQNQIKKTKPFLHLDPSKVIQDAEIFQEYPIQTKKCLSQVTKILYILSQGYSTKITKKEATRLFFAVTKLFESNDVVLRRFVYLLISELAKLSEDVIIVTQSLSKDMNSTSAVFRANGLRTLPRIIDQTMIPHLERYIKQAIVDKNPYVASSALIAGHHFYKMSPSLIKKWVNELLSAGSLNSTSSIVQYLSLGLIIRIKSEDKLALTKFVSVMTRRKEKILSPYSHCLIMRFGKQIITPETNPKIKELFFDYCYSCLKYKNEMVILEAAKTICSIPNTPKATIALAVSVLQLFLNSQRAILRFASMKIIADLGKKDPTLISSCNENLEVLAKDKHKTISTLAITTLMKSGSISQIRSLVPELINITFTMDDNLKITIIEALRDLCVQIPAEYPLYINFFSQCLRKRGKFEYKKTVMNALIYVIKMIPDSKELGMKNICEIIEDFEYDQLIVILISFLGEEGSKLPNPERFIKFIYNRLVLDKGFVRSVAVNALSKFVINNPSDPLISKKILFIISQALNDSDDEVRDRATFYSSFFNDFFKSNHLDQNSLFYFQKVECSLDSLESTLLEYKNSLVDSPLDIKALFKRGAEIDEMQKRIILQQQESKSFNINELDKHFKDLGRLYKISDIQPLTEKETEYIVKCVKYLFPNHIIFRFECTNTLKDVVLENVQIRMEKREENEFIAKKTIPIPKLKFNKTKSAFICYEFPSKSFPSGSFTNTLLFESKECDPTTGEIIGESIQDEYQLEDLTITISDYILKTEIPNFNHNWKIMKESKIPKVTQVIQFSSMKNLQDAVGTICDFLGLAPCDGTDVVKSQNSHILLLSGTFLGDSLVLAKLGMKYSKNDGVSIHVVIQSESDLICKAILGSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG98</accession>
    <name>A0A9Q0LG98_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_01924</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG98"/>
    <dbReference type="OMA" id="KEMMGMA"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000279">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018451">
        <property type="entry name" value="NAF/FISL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004041">
        <property type="entry name" value="NAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03822">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50816">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="NAF" evidence="13">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5070943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="424" mass="48801" checksum="6937F0906092798A" modified="2023-09-13" version="1">MSNRIGPYEIGKTLGEGTFGKVKQAVNVETNELVAIKVMEKKKILKENMAEQVKKEISVMKMINHPHIVRLIDVLVSKSRIFLVLELVTGGELFYKIAHDGKFDDHTSRYYFQQLITGVEFCHSQGVVHRDLKPENILLDSKNNIKISDFGLSALRSETEELLQTACGTPNYVAPEVLDGHGYDGKIADIWSCGVILYVFLAGFLPIDDSNLEKLFVKIKNAEIVYPSWFSPHSVSLLKKILVANPTKRATIQQIKQDPWFRIGYQPFHRIRAVSHIENFFKTQQKTNTDEKSNANLNAFEIISKSGAFDITRLLHKNPREKIFSYTRFTSKTKPEEIFQHLTKIFEQNPEAQIKIKKEKFKIKAHIKPQDSHPFEIHVQIFSLVSNLYLVEFTRKTGDYFGFMDLYKKIRDEIAKYIDISGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGJ5</accession>
    <name>A0A9Q0LGJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGJ5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="97" mass="11720" checksum="D521EDA8A2106CB7" modified="2023-09-13" version="1">MSEIILDQIENQISKFEYNINHNKIQKIKLDDLKEIISELPPINYLEEKKMRDFGYRLWNLGITLKNKEEKNEENRTFLNCENPDEDEDEDDIEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGQ4</accession>
    <name>A0A9Q0LGQ4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGQ4"/>
    <dbReference type="OMA" id="SQRKCRD"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="635" mass="73347" checksum="284B028E824DE601" modified="2023-09-13" version="1">MSSDLDVEKQESKQIDSKPDDSLLKQQNQNEYEYDDSELGPTEKRKCRDFFWVVLFILFWIGMLIVMAVAFSKGSPKRLYYPTDYRGNVCGFNNKDVKDQLKKDGYSDLDVSFLQDLTDKTHCFFPYDDTSNEFCVSECPSSGSFSSPPCSSGGVYDYYTSIEHCNYESESHLRRCIPTSDDQGILDTLKKDVAGSISVTMGDLAQSWWIMLVTAGIALVLSFIWFWLMKKFSGFMIWLTVFALFVVLIIFTWYLWKQVQTSEAKKTFESDKTNAKWFKVLFSLMVVVDFVFVLLVIFLRNRIRLAAGIIREAAKAISAIPSLVFFPFWTFLMLLVLYLYWIPVTLFLMSAGKPTLEPYGSNSYKLHYKNDTSTNYATIYHLFGLLWTTLVIIALTQATIAGAVSSWYWARDKHNLPKSPVMTSFKRMLRYHFGSLCFGSFLIAVVQLIRMIIRFIEKQLKKRNLDNKCVKYCFYCMKCFFACLESWLKFISRNAYIMIAVYGESFCKSTKRAFHLIARNIIRIMVLNVFGDLLLWIGKIIVTIISTMIAISILRSRKDISFYLIPALVCALLSYGIASAFMAVFEMAIDTIFLSFCEDSERHDGSSPDKEPYATEDLRKYMNEHKPKEKEKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH41</accession>
    <name>A0A9Q0LH41_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_10410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH41"/>
    <dbReference type="OMA" id="FWVGFRY"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="382"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="579" mass="67876" checksum="40C838752094BDF7" modified="2023-09-13" version="1">MEKEKEKLKEKTLSNIFKATQENEASKLIEILNSGQNPNQTDIYGFTPLHYCTIFDNFRGAKILIQKGALVDLTGGELNYTPLHIASIVGSSIVAQLLIKNGADPNKKDSQGFSPIHLAAQNNHHLFCHILISNGVSFNEVDNQSRTALHWAVLKNHIRVARYFIYNHADISIQDNDGCTPLHWAILLHRPEITKILLKNKSDLRIKDHYNSTPRDCALETQNFKTIMLIDHIQKIKKQKYKIFSPKQLSLLGFTLFFFAIISFLSIFPLFLNLLIIPLFTKMYFRFFDPILKVSEVDYSSFATSASFLVLFLSTSIFRIIPKCFSHYPKIVFIFLISVAILIYKFLITSLRDPGKIPQKIINPEELIQEENPLLKYHSSFLEKNFCETCRIFQPLRSKHDSTLQRCISRYDHFCSWTSNAVGEKNHSTFLSFISFSIISFVFYFILSLLFLLNNHQITQSSFEFFHFLYLSYFYQPWIFFLSIFSLVLLIWIIFLFIEQFLNISNNITLNERINQVRYIHFWKNQRQHNPFDLGSIYKNILQFFKLNYSVDWSKIFWFDDLKYGDCQHLKSFLIDESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH86</accession>
    <name>A0A9Q0LH86_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH86"/>
    <dbReference type="OMA" id="GYTGQFF"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="74"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="218" mass="25187" checksum="7357387BA07EFC77" modified="2023-09-13" version="1">MQPNFGDFYEAPYQKTPQNRFQNTDRVFFQDSLGQNRTTSTTRLDFDQDFNEPPLLEELGINFSHIYKKILSVLNPFKRVDHFFLQDSDLAGPLLFFSLLGFCFLLSGKIHFGYIYGVGTLGNLLIYFVLNLMSTEQINLYQTISITGYCLLPLVILAFCRLLLPFGFVFILVPVCILWSSYAASTIFVEILEMKEQKWLVGYPVFLFFTCFAIMAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH96</accession>
    <name>A0A9Q0LH96_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH96"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25969" checksum="F098DFDB7F9581CE" modified="2023-09-13" version="1">MGNKVLKRKETKIYYSMVQKSKEAITIINLDGTFNFANESAIRCFCVPSLEYLFNHDIYTISPKNQPFLLKDSQSTFDSILQKLNSENEENWLDCSAISLTINNKQVIQVLLIEIFPMNQEKLEELRKDFELGIFNQEIEDLIRSSFYPLLKNNKKQNSTPKIAKKRSVSVAYPSNQLQSKSDSNINFNLTQIKMIMKMLIILKLKMINIFLNQHLVILNLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHP8</accession>
    <name>A0A9Q0LHP8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NUC153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHP8"/>
    <dbReference type="OMA" id="YEMEMSW"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="141"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="277"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="91078" checksum="A52A97B5C8293150" modified="2023-09-13" version="1">MNPNENDDRFSARFSDPKFKKFSKRNLKIKVDSRFQKMNENKDFQKTAKYDKYGRKIKTKTFEPNNYFEIETEETQRKGNKANKKMKFIELENQLENHKSNSKSKSKNKFKSVSIESSENDEDEKDNNFYYDKNHLDGEETKRIAIVNIDWNFIHAVDLLSLFRSFLPTTGAVLSVKIYPSQYGLKMMEKDEIYGPPRDIIQEKEKSNINKDDKNINKDDKNIIDDKNINDDENINDDKNINDDKNIIDDENNIIDDDENIIDDDNIFGTEYSLSNFQESNDESFDQEKLRKYEKQKMRYYFAVAEFDSKETALSVYNNCEGMEYIQSSNLLNLSFVPDEMEFEQKPKEVATDVPSGYHPINFYTKALQHSKVELTWDQPDARRQIILNSKLEDQEINEDIYQEFIASDSESESESESESQPKMEPNEAANSNSEKTETNDEKINDEKKNNIQNEEEVKKLKPKYRNRFKELLEHIHQKEKEQEDIEITFIPGLSEKAQEILESKKEKEESQNKSSWEKYKDKLKEKNKLKKKSKQDKNRSKDEDENSQDENDDQSLFSDDIEIDEDDPFFISELGNSFRSKKKTNKKKNNKKKQMDQETKNEEMKKENQEKAELELLMLNDKVKFGDNLSKQKSQENEKLILNQKNKKKRKKEIKEDQNFQFNPQDERFNRLYDSHLYNLDPTNPLYQSSQATNEIRKEQLKRHEHLHEDFENVDQIKKTKLSLNSNQNSNQNSNQKKEFKNRNSQIDSLVSRIKRNISQKSFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHR7</accession>
    <name>A0A9Q0LHR7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tumor suppressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHR7"/>
    <dbReference type="OMA" id="LWLPEPY"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="11">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="10">
        <location>
            <begin position="268"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="335" mass="39458" checksum="B212EB8C96D584FB" modified="2023-09-13" version="1">MSNIVEFWNKALIPYSHKNEVKTALEEICLLYTDLSIGVCPFKKGDGKLVQVLHLKGNINATQNGKNIRIPLGIFLFEDFPNSAPWCQVFPPNPNIKLKNTKNVDFMGRIYLPYLVKWKSHHNLTELFEHLVSILQTDIPFEIPKPQPPPPQKKLEDPPNLKRFDSSLYPKEKTLKEKVVEKITDELDEFQKKHQTEVDNLFQKQAELEQNYDNIKSLIAFFNTQAEEFQNISYVLNEKQKEFEKWSEEYLSKNFDSLDINELIIPQDELTRQLFETYAEDASIEEAIYYLDKALKNKVLDFNEYLDQIRSLTQKQFLAKYLQKKVLETQKKLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LII4</accession>
    <name>A0A9Q0LII4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">26s proteasome non-atpase regulatory subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LII4"/>
    <dbReference type="OMA" id="IMFGRQE"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="6">
        <location>
            <begin position="800"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="860"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="965"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="875"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="991" mass="112313" checksum="63C1DECF97AD1661" modified="2023-09-13" version="1">MNANLTSVSPIISYLEEEDPKLQTYALKKLNELVDQFWPEIADSIGLIEKLCEDQDFVSKELASLVASKVYYHLGSMNEALNYALAAGDLFDLSNKSEFVETIVAKCIDEYILIRSQTEEEKSQEQLRKQAELLFNIENVISKMFQRCFEDGEFKQAIGIAIESKRLDLIKETIYKSGNIPETLEYCLKITNKYVLKRSFRQQILQLLIEIYQSEQKEDHIRICELLLLMEDTEKISEILMNLIDSEKEIDILTAYQIGFDLCENAGQKMLSEIKSRIPDPIEEKQQTKMQEEKKLNNDNDNDNDEKKLEEKTEETKETPKPNLKPEKIKKLKAILNQEYSLKLLLQFLNLNNHTDFQILRQIKTKMDTRKIALRTTTVTAHGFMQAGTTVDSFLRGNLEWLRKINNWGKFSSTASLGVIHKGHIAQALDLLSPYLPQNGRSESPYSEAGALYALGIINVNHGETSTPYLLNMLRSLDGNEILQHGACLGLGLSAMGTLNEEIYEDLKAICYSDSAIAGETAGLAMGLVMLGSASESAIQDMLVYAHETQHEKIIRSLAIGISLIMYGKEEAADTLIEQLLLDKDPILRYGAMYTIAMAYAGTSNDKALKRLLHVGVSDVNDDVRRAAVIAIAFLLFKEPEQIPQTLSLLSKSYNPHVRFGAAISLGIGCSSVKSLQVKKQAIDLLFPLTKDPVDFVRQGSFLGLAMVLMQINELQEPRAKLVRDMFFQSVSDKAETLMAKIGAILGAGIIDAGGRNVVISLQTNSGMNDITSIVGLSIFTQFWFWHPFVHLLSLSFQPTALIGLNINLEMPKFKVKSNANPDLFAYPKPLEISEQKKDITIEKAVLSFTAKALKREEMKKEKKQEENQENQENQEIKENQENQENQEIKENQENQEIQKKDIPKKENFEILQNPTRITLIQRDYVSLDIDERYRSIKSNAQFGVILLHDTKPDENEELVIVEEKIQTESPQDEGEEPEPPEPFEWIEDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIQ4</accession>
    <name>A0A9Q0LIQ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIQ4"/>
    <dbReference type="OMA" id="NDFIFGE"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="86"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="708" mass="83441" checksum="7D3F456D3CA1B1D8" modified="2023-09-13" version="1">MTETSINFFDIKKKEKDYLWKIETIRTIHKRRYNFKHSSMEIFFQKSRKFVFFNFPTMETRNEVYEKIQKHKFINIDQSKYNYSGNDPTKWIEKTQVVKQWQEGKLTNFEYLMYLNTISGRTYQDVSQYPIFPWIVCDYGSEKLDLEHPETFRDLSKPIGKLNNKIMTYFEKYQKKGKEKEIQFNYHKYYSNPEIVSSYLVRLEPFTSIFLQGKYAIFKSIPETWKTIKESNNDFIFGELIPEFFHLPDFLRKPTVFKQENEAFKQIANVELPKWAKTPEEFIRKHKEALESEYVSQHLNEWIDLIFGYKQKGEEAKKALNLFHPNLYEENADFSELEQIRKEIQAKGQVPIQLFTKKHPKRLSKKEIQQKSFPFSFSLSLSSSAGFQWGNISLSESFHSTKFKISSNPIIFINFQEVAKEDATPKFQHQITTIDKERILGKHGWEFLNKPNSKNRFFNFYLHAMTEKQAKIGVSFSQDFHNLQGSFQMDKNLRFLICCGFCDDTFKIFDAENYKMTQSVSRHKDIVNCLAIDSRYLVTGSKDTTVIVWEFSLRSGKVRQEPQTVFFEHEKEVRSVALSVDYDIVLSGSVDGKLIFHSLNKAKASNIITFSENSKILRLFTINGYLIKEETCSQNIYAISITQDSSVVFLGGDKGIFETRNLFDLQLIRFFDFKEKIYSLSIIEKVFIVMIGLGNGQIKVGNFIENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ45</accession>
    <name>A0A9Q0LJ45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="KNEIQMQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480:SF1">
        <property type="entry name" value="ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1556" mass="183927" checksum="D93C86D5C1A7D23B" modified="2023-09-13" version="1">MKYKTTQINETIDQIIDKKESKSKSKSKSKSKSKSKSKSKSKSKSESKSKSKSESKSKSESKSESKSESESKSESKSKSKSKSEKDEIIDKNEIQIQQETQQETEKETEKETEKETEKETEKETEKETEKETEKETEKETEKETEKETEQETTTQINETIDQIIDKKESKSESKSKSKSKSKSKSKSESKSESKSKSESKSKSKSESKSKSKSESESEKDEIIDKNEIQMQQETEKKTEQETTTQINETIDKIIDKKESKSKSKSKSKSKSKSKSKSKSESKSKSKSKSKSKSESKSKSKSKSKSKSKSKSESKSESKSESKSKSKSESKSEKDEIIDKNEIQMQQEIQQETEKETEKETEKEIEKETTTQINETIDQIIDKKESKSESKSKSKSKSKSKSKSESKSESKSKSESKSKSKSESKSKSKSESESEKDEIIDKNEIQIQQETEKKTEQETTTQINETIDKIIDKKESKSKSKSKSKSKSKSKSKSESESESESYSEKYRIIDKEEIYKSNTLSNIENQNGNIKQIEDNQEIIKKPENINQIQNQIENENENENENITYYIQKFYELIFNTKINYSNIKFNQKEFIENLNEKEKKIFKKIKKIDKIGIIKYEINENENENLQNCILHHEELYQLLETIDAILDQLLIYIKDGLIEDSNILLSTFIQIADQSFDESTYSDNEIKKHLSVFYKNEEIYFEEFKKLNVSENNTNLQELFNNFLEIYEPFLDQNNTKISEKLYSKFQEIGNQIKQTTQIMKQKIKIFKTKVENNFKQIEKFLKLKKENNQIEYNNEIEDNNQIEYNNQIEDNNEIEDNNQIKDNNQIKDNNQIKDNNEIEDINQIKDNNEIKDINQIKDNNQIEDNNQIKDNNQIKDNNQIKDNNQIEDINQIKDNNQIKDNNQIKDNNQIKDNNQIKDNNQIEDNNQIKDNNQIKDNNQIKDNNEIEDNNEIKDNNQIEDNNQIKDINKIEDNKEIEDINQIKDNNQIEDNNQIKDINQIEDNKEIEDINQIKDNNQIKDNNEIEDINQIEDNNQIEDINQIEDNNEIEDNNEIEDINQIKDINEIEDINQIKDNNEIEDNNEIEDNNEIEDNNQIKDNNQIEDNNQIEYNNQIEDNNQIEDNNEIEDNSQIEYNNQIEDNNEIEDNNEIEDNNEIEDNNEIEDNNQFKDNNEIEYNNQIEYNNQIEDNNQIEYNNQIEDNNEIEDNNQIEDNNEIKDNNQIEYNNQIKDNQIEDNNQIEDNNQIKDNNEIEDNNEIEDNNEIEYNNQIEDNNQIEYINQIKDNNEIEDNNQIKDINEIEYNNQIEDNNEIEDNNQIEDNKDINQIQNQIQNENENENENENITYHIQKFYELIFNTKINYSNIKFNQKEFIENLNEKEKKIFKKIKKIDKIGIIKYEINENENENLQNSILHHEELYQLLETIDAILDQLLIYIKDGLIEDSNILLSTFIQIADQSFDESFYSDNEIKKHLSVFYKNEEIYFEEFKKLNVSENNTNLQELFNNFLEIYEPFLDQNNTKISEKLYSKFQEIGNQIKQTTQIMKQKSKYLKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJA1</accession>
    <name>A0A9Q0LJA1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase tnni3k-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01458</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJA1"/>
    <dbReference type="OMA" id="AVHICQY"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000034">
        <property type="entry name" value="Kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="120"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="373" mass="42631" checksum="6669FC1A2C7156C2" modified="2023-09-13" version="1">MKQDDKIPMDVASPEIKEFLSQIQQNPSKKPEIIKQNENIQEKKDEPKKIEAKKPIKNIIQEIEPSDSETSSTDDELGTVVLTKRDTVKEESIIQKQDDPNSVLDYPIMKIDKEIEFEQLDFVKFIARGSFKEVFKGLWLGLEVALMKLLCSGNLSESELREFKSELSLLSQLAHPNIVQFYGACTKEPNLCIVTEFCHGGTLLDYLQSDAEITRKHQYEIALDIVRGIYYLHANKIVHRDLKTPNILLDRHGDAKIADFGLSKTVNAARTHLNTLVGTFNWMAPEVMYGQNYSFPADIYALAIILWEISTRKIPFEGISAANLTKMIAIEKKRLPLPQDGIFNSLIEKCWDQDPNKRPTIKEVLMKLQRIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJN2</accession>
    <name>A0A9Q0LJN2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJN2"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="489"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="67927" checksum="5A6BFF50C2CBE5B5" modified="2023-09-13" version="1">MINLNQLIRKGDLKEIKNNITKENISIRYNETPLHIACKFGADFEVIDYFISIGADPNAKNNATPLHFCCMKKAPFNVFEKLILAGAIVNSLDNDSPLHSACKNKLDKNIIELLIKSGANANLQDGNTSLHNACAFNLSDELIKLLILSTNDVNIQNKRTPLHNVCFGKTPSLEIIKLLIEAKADVNLKDGFTSLHLICQKKSSYEIALCLIKAGAKIDEKDDNIPLHFALENQNDLKFIEVLVSNKIGINQPNGNFPLHLYCKSGSSQNIVELLIKSGANINCQNGETPLHFACLLGDSNFIHFLVSIGAKINVINKDTPLHFTCRNYKNLQSIYWLCLFGSEIHLKNNEKPVDCTYNQEVKEFFERFESVCEDIGKLFKRREFCDYEIKLKDCVIPVHKLILQTRIGETKFEKAINFLKKKRKFEIEIILKFIYSGLIKENDYQRNYEIINEFAEGIEENEEWIKKKKERKGLIEDLKKLYEDENGKDFIIISEDKEIKVHKLILQARSELFRGMFVSVNDNSNRVNDYSDKSNESLSYFIKFLYYDEIDYGMKESIYDDLEELQDFYQLNERSFLRDHIDNLKSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLP2</accession>
    <name>A0A9Q0LLP2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLP2"/>
    <dbReference type="OMA" id="EHYWITE"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="306"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="526" mass="60855" checksum="17AC3A8E85595881" modified="2023-09-13" version="1">MQNEIKNQFPSGNNFKAKRKIGKGSYGTVYLGKTLKTKEICAIKKIDLSQTENQEKTRRNVLLEIQIMKKVKHENCVKLFFIEPENYQKSDLIYVVMEYCNMNDLNHYIQSKNKRISIEEMKEIFRQIFQGLKYLYEQGIVHRDLKPENILLQKNEDSKFGYTIKLADFGFARKIPKDDLGKSLNMQSLVGSPIYAAPEILFGESYTSKADLWSLGVILYEIVTGSIPFSAFGINDLVLIYKNTTKKSLPKKVLNVVPKECNDLVEKLLTVDPELRISRQDLHNHPFISEQLKESVEKSQSLLDLEKGIIGITKEDFESKENDKLSFKKGDIIEIIKIKKDKEICEGILKEEKGIIELKSIDLYQKIENIFSIIESNNKIKKFQKRIIGITKYRYQANQFSLPKGELIEITLINGEMEICEIQFENQKDEIPFFFLDFYEQIGGNNGNQNQIQIQNQIQNENQNENQNKLIGIARVDSQDNEDEHFLSFSKGDEVEILEINEKIGIAKLNGKEGEILIDDFDIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLS9</accession>
    <name>A0A9Q0LLS9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_06708</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLS9"/>
    <dbReference type="OMA" id="HNDANRN"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="12">
        <location>
            <begin position="227"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="553" mass="65234" checksum="402257B129E28469" modified="2023-09-13" version="1">MEYFKRLPKFIQIIFIFILIGQFIIFIILNNQISSKNNLLNEKEIILIKNENEIICENEIICKNKCENIIKENNTLPKSFQIIKEIDSEITRRCSERFGDLFIKNWRETQINICSGYGLSHIQCYKRGNSPKPQLLCVAENSEIRGYSPYYIADSSDISKITHVEINKGFLHVDCDDSMRKWIPETEWEERLNFVMGNMETNSDIKCEHWINHTVFWIWRWAEAVTYHFFEDFITVFIQLLVLNEDPQNVQPVFIDDIARGPQLYDFWSVLFGYEPKILRVDPFPKNTCFKKSIFRMSASFSILYIELWLNSEKKCKFPMLYALKNYIFERSNISFDNHIHKSPYTIAFVKRENYNGTIIKRTIPNYDIVFNYIEQKLPKNWKIVKFQPEKMTIPEQIQFSSNISIIIGPHGSALTYLLFMPEHSHLIEIFGGNRSPNMGHYKNICTYLNHEYHNAGYFNDDVSEKEIWRGFIVGLLSGAIIMPYITFGTTRKILLLICIPLLGAYFAILFIFFYRDIDGNSWCSFCKYITCIPVKDWCDNIGPEKHTKTDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLZ9</accession>
    <name>A0A9Q0LLZ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLZ9"/>
    <dbReference type="OrthoDB" id="449062at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="688"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="728"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="803" mass="94819" checksum="C5FBC11AC4AFD47D" modified="2023-09-13" version="1">MSFECPICFERYSSKRKPYTICQEGHCICGLCLQQLAECPFCRVSLDYYPQTFNRTLLQEMEEQERKKLEKKKKKMQQIQQEKIEQQKEVKLEVIPPDQYQKEKLKGIEAMIKVMNNFPNNENIQYQGCQSLTAFALKNQENQKEIQEKKGTEAIIKAMNNFPNSENIQNQGCEALKNISLNNQENQKEIREKKGIEAIIKAMSNFPNSENIQYKGCEILKNLSLNNQENQKEIQEKKGTEAIIKAMNNFPNSENIQYKGCEILKNISLNNQENQKEIQEKKGTEAIIKAMNNFPNSENIQYQGCEVLKNLSLNNQEMQIHFQFPILNTQNSTNQFGKKINWSPISNKNKEKDLKGYYQRKKQKKKEKKRRQNQNRINHQKKSNSIFGFFKEDYKEKDKSKKDKKEKDKKSKKDKKDKYREKDKYKEENENQKIPTLDLNLISIIIKAMNNFPNSENIQYQGCEVLKNLSLNNQENQKEIQEKKGIEAIIKAMNNFPNSENIQYKGCEILKTLSLNNQYIQIHFIFEIDEKSKTHKNSIPQSNRNQNPIYNRNQNPIYNRNQNPIYNRNQNPIYNQNQYQIRNRNQNPIYNQNKYQNQYQNQYQNQYQNQYQNQYQNQIQIEFESESESESESEYENENQKIPKLHLNVISIIIKAMNNFPNNENIQYQGCEVLKNLSFNNQEIREKKGIEAIIKAMNNFPNNENIQYQGCEVLKNLSFNNQKIREKKGIEAIIKAMNNFPNSENIQYKGCEALKNLSFNNQENLDEIQSLQGIQLIINLMNNFPNNSSLQEIACETLSQLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMI4</accession>
    <name>A0A9Q0LMI4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMI4"/>
    <dbReference type="OrthoDB" id="9991832at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="7">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="431"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="500"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5074505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="65912" checksum="CFCA49B490D010FC" modified="2023-09-13" version="1">MSFIDLWDSHDLIQDLTKETSQKGKEFQDFFAILAITHLEYSRELKKFSDKYEAKMSSKVTRSPVSSSWASLLNESRIISSIMEQANKDLTDNITKIRQPIQSYIDPYYSLQKIKAEKEELDKAEKEFESIKRTYFQKSKELEKYEIKAFKTKKPIPQLQTMRKNQANLESQYMEFHSKLEKLYKQFKENSQKNLIAVQEAEQNKVNQVKEILTTYLEQQKQFLEEIQTSIKKERENITFTNEEIEEYIKKHFGIEENYNPIITKTTYENKYPHEEIKKEEDKKEEEKKPKRKYKKPKKIQYKDSEDSEDSEDSEDSEDSEDSEDSEDSEDNEDKKDKRKKFKDKENQSKIIKKGILEGMNFDFDVMKNIRMKEAEDIPQKKLNKGLRKIKDQSYRPRSLSQTEIENVKPKNPKSSAIQIVTQDNTRPQKSNKIYAKVISDYDPQKEGYLAIKAGEIIKIISQNESGWWESEKNDIVGLVPSTYLEVVGHEQRSLSVEIKTTKKVVSNYNYRKRDETELDMKDGEVFTLINKFEGWYFVSNSEGREGYVPACFVDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP81</accession>
    <name>A0A9Q0LP81_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MORN repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP81"/>
    <dbReference type="OMA" id="RRYVGEW"/>
    <dbReference type="OrthoDB" id="423343at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="85547" checksum="BF8AD9D14ABD92DC" modified="2023-09-13" version="1">MKELERMMSSRITGSFIRKLISKSEIPIDISYILNLPIERLEEYASFVKQFYVITPRDHPDIPNLIKLQEEFKEITIFVQQKISNDIILDPQSEELISKLKISRVEVGKVTKYDYNPKMNGKSVQLYLFTNAIAWCLPDEKSSVYSLDYFVSINLVWLKERASGKDHLGILNLDETETENETETETERQIFNQSENQSENQSENQNQNENQNENQSDSENENENQNQIENFNQNLFQTHNKVHSKIKSQNQNRDSKQYTISTLDEFEIIVPERRIKIELPTKTEFIENTLNNMVTECGFTMEEITSNQPRFVKYVFHNQTEFSGYFQDAISTGESELRYPNGTFYKGSFLRGKKNGEGVLTFPNGDVIKGTWKHDHLNGKCEVIYKSGSKFIGDYFYGKRNGKGELLFFDGSSYVGDFSNDLYHGKGILKLPNGSVYEGSFKNNFRDGFGTFIDNNEKYEGEWKNDLRNGKGTQNYSNGDVYSGFWKDNLRNGEGTLTKNSSQIYSGEWKNDLKCGFGTIVYDSSKSYSGEWLDDCRHGKGEFINSNLSYDGEWKEDFPNGFGELKRALKSFPIHKIEISNTSNNQNNNNNIQIQDNFPNIPIKILEKIIGQFQNGIPTGKIKHIIEDRFESEMNLVEGKKKGKGSISFHNGSKVTSYWDDEKFNPDKQTEMKFLDGDKLTNITYSPKHNFAEKLELNSGKSNTQITKQIEEHIFRIKESPNNWLYPPLDSLLFESFWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQC2</accession>
    <name>A0A9Q0LQC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sorting and assembly machinery component 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_05531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQC2"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="119"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="453" mass="51875" checksum="0898ADF77D9ABFB6" modified="2023-09-13" version="1">MNQQKFFDQPLKILAIKIIGLKNTKKDIIEKNFNKFQQVKTVGDAFYITEEIFTKLKNLSIFKSIKFNLDKAIVKDNSNANLSVLDVEFEEKSRGPNLQISGNFSKKGFGGSISSKIINMFGRGEKLHGNFSIGKDSRNLLFDFSKPILSIFEEKIPTINFQAFHNINPNEKLNFKEKIIGSQIIMSSDIINPELDNTRRGIGFSNLLHSLSFVCESRSVKTLKENSVDETNQKYLGHSWKTSLVHDLYLDRRDNHLFPSKGYYFHVSNEIATTFANQTSSFIKSTIQTQKNFPIYKSLRLNILNSFGFILPLFSSQEIKINDLFPEHTRSFCRGFKLNENPDSKNFGGNIYNFLSAILSFKLPIPNSEKVPIYPQLFTSIGNIQFKESLQFSNFFQFFHQLLKLSDSVLGFGLATQLGASRLEINASYPIITKEKEKKEFSKISFSFDLHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQY2</accession>
    <name>A0A9Q0LQY2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQY2"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="670"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="853"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="906"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="935" mass="108751" checksum="DA00D933F7F6F8EE" modified="2023-09-13" version="1">MSLNEKIKNLIINNSISELKTIIKDFDIRSELDKLSVLHIACRNKPKEEMIIFLLDQGADIEQKSGNTPLLHACRNNASYEVIKLLIEEGANYDVMNIHNALSLSFLYHDDINVIKLFLDLGLDPEMKFDYNLLHFAKIRTVYNPEIFNLIIKRTDGRLLEQRDGFIPLHHAVEKGIIDYVKILIDNGSDVNSIVNGRTPIHMCPNIEVAKLLIKSGASLKAVDNSSVLHYICSSFPDPELIKFLIDQGADPKALDNVIFFSHFFFMGHTPLIRLFSRKSNVEAVKIFLNKEQIELMTSRGVNVFSIAVNEDTPLPILELLIEYITKPYESTTYEISFFEAISRKKFTSLMALILKRFPITKFNDLTISNFFANIKSPEVIETFIDGLQVPDEQLIENLMDFNLDSQIVTKLLKRINFSNFSHKAIYIQKSISLLNFNFFIAFINEWKDEPLPIYGLRSEKENLLHKVIQYRDPSIIKLLISKGDDVNFISSGKTVLETLIEHNPNPNKEILKILIEAGADLTRIVNGKPLYNMINDKVLLSSMILSKPYNDKKIYLNTILKDVEQFITKNENLEKITIETKPKAIKTSKELIELNFGKEKKEKVIEILSKKTEKEAKLILDWLCYDKFTSQDEVKIIRKFSEEVLDISLKTNILPFGITFEHLLNEESKDFTLIDKNFSFEVHRLILQVRCPFFQKFTKESKLDLTEFYFSTLAIKAFIEFLYFDWIDLDIDYSTLNQFKLILDFFKIPIAKDIVKIINSYQRVHSVHLIYNNFKKNSKDLKDLKDLEDLEDLKDLKDLEDSKDLKDLEDSKDLKDLEDSKDLKDLKENLKENLKENLKDNSKDLKENLKENLKENSKENLKENLKDLKDLEENSKDSKDLKENLKENLKENLKENLKENLKENLKENLKDSKDLKENLKENLKENLKENLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRB7</accession>
    <name>A0A9Q0LRB7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Twinfilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_00565</name>
        <name evidence="11" type="ORF">M0811_00594</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRB7"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="177"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5077274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="438" mass="50805" checksum="86C32D7E504A45E3" modified="2023-09-13" version="1">MTLSSKIKEKLQQSFESDKTRAIIIGFEQENELEAIYVMDDSLSTTSNSDFEKIKKELKADEPNYILYKLKDSPRNHPKWLLINFVPDDAKVREKMTYSSSTNILKNFVGKLLTDTWQVSDIKVFSWNDYQQSKDKSFKPWSRGEILRFKAREMEDTARFEMETQQSLTKKIGGYHSVEIPFNNEVENSIKEFINGEFNWIELQISQNKKEIIIGSKKRLQRGSPEDIKEYIDKDQPRFYLHQDRTVTHFIYSCPPNSPIQLRMVYSTAKPGITSQSARLGLTINRKHEIIDLDDLMSSYSRRRSWPGKEANTFSQFGYQTRRTTNFYNPQQNLRKTTWRSSTGNEPKFPKPRTNVSRTGLAFSGINQTVSSPPRTRVNQNSNTSYSPPSYRSQNQNTRFPRARKTAQLPGYVSWSSAIKSNAEVKKNIVVAPRGGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS33</accession>
    <name>A0A9Q0LS33_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G1/s-specific cyclin-e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS33"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="457"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="778" mass="91686" checksum="005159701780CEBB" modified="2023-09-13" version="1">MLSYNRSDIDNTFLFNVKMPLSQQINYPYHKPLIRNKQTAFGSKKSSIKQGGKEEEEERLEIKNNNTIQNNKEGGYIYRNSYGNSYDYDYDCNYNYNYNYRNGNQDIRSQNQRINVNEPIQADCFTYPSHSSVYNSHDSLNYAYNLNQFFVFPFVDKPYNSTQKSTDFNFLQNCKENQLTMLQPNYLSFPGFVSDKNNSANFMVEGKQMANSYPNGRIWYGSNSLDLEEQERRIRNEKMKIDQEMKMKKNGKMIVNNKMTVNNNMTSNNNMALNNNMIVNNKLVLNDRINMNHKMALNRKITQSNYILDNSLSPDSDSHSHPNSDPDFDNLPRVNSIFMSHVSFPSKSKFPPPDFQSQMTSCNRNPTHFPKYTFDSYHLNINRHVTSPKNTYSPLSSCYDTLAQEQPSDVIEANSTESELFQQLRFTMFDTEAKFQADPNYLYRLQLNEMSRVTTLETISRISCQFDLKMETFLLAVNIYDRYLSTFQKIGSKQFQLLLIATTSLVIASKLEEVYPISIVTICKNFKQKFQKEDVIQMEIEILKKLNYSLLAITANTWISLYLFYSCWIWESIQFPKHYVKKGSFDLFIQYSQFHPKKHHLDQVLSFFCTSKSQNQNLCTKKLLHIIKFPVDLYHDLMQLIHLAILDPFSLNFYPSLLAASALSLYFSYDAVKKITNYSKRELYQCREWLKIFISFPSRSHRNDDFVTSQYNNQTNSNFNQSRNQSQNFNYENNSFLLHYHSPFAESFVKNLIYKRRIPNSYQNEFSQKFNSFQSQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS44</accession>
    <name>A0A9Q0LS44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS44"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="214" mass="25699" checksum="EB11BD44E14132D6" modified="2023-09-13" version="1">MNQKYYFFFYPGKNETSNDISFFIINDPKHSKELNLLENENENENENENKNENENKISTFIYVFEDKDENIQQIGSIKISIFYQKTGKNISSNLKFEPNNYFYFIISDTLKEKDHTQIGIFFLHKIFGEFIIQNDTQNSSKFFQVLKAIKSLEKLEIFQNEFPLIISKYLRMIFKNQIQNQIEIENQNENQNQNQNQNQNQNQNQNQNQNQIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSN9</accession>
    <name>A0A9Q0LSN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSN9"/>
    <dbReference type="OrthoDB" id="10673337at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF15">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="403" mass="46283" checksum="4CC3B865CB445EAA" modified="2023-09-13" version="1">MNEPTLDLVILFLKNQANLNSEDKNNPLHFACLNEVETEIIERLTTTTNLNSQNGYTPLHFACMGNNPKTVELLLKSGAKPNTKSGWTPLLLACEFYGNVEMVEHLIKYKAKTNIKTQRTPLHIVSQTKENPKLLIELLLNAKNDKDQKDKLTFDQYLDLFTTEGLGNLSENRSLIPIDSKKKLQFSICNLDSRIIDDFKKNLRGHSIFKMYKKDLFNLSGDAIVIPTNSFGILINTLGTISKDFFGVEFETEIQERIKKEFYGEILVGECMIHPIDSRNSNFPYAIIAPTARVNEKNPKSINPFLTFRGILIEIFKHNQKCQEDSSIRPIYNVILNGLTTKKVEPISQSFPKELFEAYKIVSEYFSSEKKEKKPFPDSFDLVDQQNAYFFDTKIKLNSNFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT75</accession>
    <name>A0A9Q0LT75_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Microtubule-associated protein rp/eb family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_04883</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT75"/>
    <dbReference type="OMA" id="ETMPMNS"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="13">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="209"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5078558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="311" mass="35940" checksum="4D509291C9EFA9EF" modified="2023-09-13" version="1">MANTSIGMMDGAFFIGRKELLSWLNNLLKLDYTKIEECKTGAAYCQIVDACFPGKVALHQVKFDTKFEYEYTQNYKILQSAFQKLRVEFSADATKLMKGSYQDNLEFLQWMKRWYELNNQSEDEYDAVSRRKESGITVKSPTPQKNTPRTSTTKTKTTQKIVRRQTKPTPKKKTTSTTTPTSKTSKTNLNPSKNTKKIVKKITKTSGDTSQIDKEKELLEQQKEELSNLLEQSKEIAEGIEKERDFYFEKLKKIEELCLENQENETLSNILDVIYAGSDDEDEKEVVENEDDNDNDNDNDEQEQEQSDDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTQ7</accession>
    <name>A0A9Q0LTQ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Golgi apparatus membrane protein tvp15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_05435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTQ7"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="197" mass="21645" checksum="9AC32ADD44C9E642" modified="2023-09-13" version="1">MGTPHLVFLLKVLSGIVSTAMFLCGFIGIAKSTGGSFKVDEFYLTFNALFFSIVIAVAEFMEFPFFFQKLGFAKGYTGRGFLSILLGSFGVACGQNHTYLLIVGILTCIYGLAILILGMTILQDERKGIESDLLSTTYSRKAVYTTAVADQDNKEENQTIQPKNQEENKEDQQNKDEKETTTTTSSTSSDSDSDSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTU4</accession>
    <name>A0A9Q0LTU4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pci domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTU4"/>
    <dbReference type="OMA" id="INRMFTL"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="202"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="386" mass="45748" checksum="C3EF064CB364BCD9" modified="2023-09-13" version="1">MFRNYLLNIKKNIQEKNGIELAHLLSISQENQNNQIIKEIQEQNINFEDDCFKLLPNDWVQIIISHLESLLSISIEQKFQTHSESLNNFLDLARDQTNWLISVLQQMAKDLRKLSIHIYKQNKVNEEFLSKAARVLNKCLEITNNDHSSLETSKKWGALSIILELFRIYFFTNKLHNCGHFINVVEDSSFPNFENFPIYEKVTYKYYVGRMHLLSEEYQLAQEDLNYAFQNCSKKYPKHLKMILFYLVPVNLYFGKIPSDSLLQKYDLGFYIQIVHSFIKGNVNFYDQEIQKYQTLFLKKGIFVIFQSIRILVFRNFMKKFHSIIQNTKIPIEDIQKGLNIIGVDICDNEIKCILSILIYQERIRGYISYTHPFLVLAKKDPFTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU57</accession>
    <name>A0A9Q0LU57_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rcc1-like g exchanging factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU57"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="328"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="497"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="600" mass="70191" checksum="36D61AB1695DEDD1" modified="2023-09-13" version="1">MNDCLFFGRNKEPKLFKNKPEKITKPIQFKFENENENENENENENENEKQIKQISSSEFSTIFLFKNGKAIEYLKDSNQNPQKIQIENIRKVSVGYDNEAILTIEGNVFAKGKDIKPKNPNEFINISSLIEDTNDRIIKDIVSGRNSIYLLTSNQNAYGIGSNKYSQFGFDSETLPKTEKPILIMKNISKIFSGNNSFHIFLLNSNQELFGCGGNFYGQLGLGESRIKETEIHKLTQIQNIPKGKIIDIQCGYFHSIMLIENENENENRDENPKRKLYSCGNWIYNGLGKNKNTYEFTEIKSSLFENDDNILDFSIGLEHSLILTSKGKLFSFGDNVFGQLGTGDTNVQLIPIQIELPKLRFNEDISNYHVLCGRYNSFLYYSPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNEIEKLQEIISNKSIKESNQIFEMIYSNRIINPILYSEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLIKKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUA7</accession>
    <name>A0A9Q0LUA7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="12">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_04519</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="12"/>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUA7"/>
    <dbReference type="OMA" id="AFLYQMC"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="16">
        <location>
            <begin position="321"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="421"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="680"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="977"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="724"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1131"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1006"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5078796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1180" mass="140798" checksum="8CF8B61D6F918885" modified="2023-09-13" version="1">MGVPAFFRWLTRKYPKIITACKKQKEEEENVDYRNPNPNGIEFDNLYLDMNGIIHPCFHPDSGLKPKSWLEIFHNIFLWIDKLFAIVRPRKVLYMAIDGVAPRAKMNQQRSRRFRSARDYLAKKRSKQNEKVFTHENIGNIDLEKEKEEEENFPLTDSNIITPGTEFMQKLAKQLIFYICDRLTNNPAWENLKIILSDSNAPGEGEHKIMEFIRRQRIQPGYNPNTKHVLYGLDADLIMLGLATHEAHFTILREVQFFSEAQRESYIESNNQAPWTTEEIQYYPMSDSTEKDPDPYIFLHLSILREYLFHDLYNPNLPFGFNLDRILDDWVFLCFFVGNDFLPHLPSLEISENAIGVLMDLYYQLLPSFDGYLTENGDVQFSSLKLFLAKLGEYEDNIFKRRRERDLARVIEQERRKAEENKYKKNMDNFNPNSIGHGNNKSPLHNNNKKENANTQDLNNAKEQEDNSDLDDVDRVQLGVEGWKERYYEDKFKIQITNYKQISKISYHYIQGLQWVMKYYYQGCCSWRWFYPYHYSPFASDLSEFMPQKVDFVKGAPFSPLEQLMAVLPPLSRHALPVPFRDLMIKKNSPLISYYPEKFIVDLNGKPKEWMGVALLPFIDEDKLLNNLNLLYPKLNDNELERNSIREHLFFVRYSDKVVSTLLKLIPEVNDEIPKIVNKNTQENNLNEKPYLQKQNPRKRSIDSNNNLEKDFTEDEIIKRTKTKGNQNQNQNQIENQIENQIENENQNQNQNQIENEIENQNQNQIQIENQIENENQNENENQIENQIENENQIENENENQIENENQIENQIENENENQIENRNENENQIENENQIENQIEIENQIQIENQIENRNENQIENQIGWVWITTCFGNDDFFGNIKRSQYSILFGKTYKSTILDFCPSIPKNLGLIFTYKNPTNIPENYIFESRLLQGINPPRRMIRSNDVYFTKNRPKQSSKFLQNIVNINNNTRYSRSFHSNNLTSHSPYSEKDHQNYHNQSGYNNNHHHHHHNHNHNHNHNHNHNHNHRSSPNFYSKSHSLNPENLPNNILNQYYQQQYINYPQYQQQYITNPQYQQYINNPQQQYYQQYYQQQYINNPQQQYYQIQNQNQNQNQIQIQNLNQNQNQNQIQNQNQIQNQNQNQNLNQIQNQIQNQNLNQNLNQNQIQNQNQNQNLNQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUR5</accession>
    <name>A0A9Q0LUR5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">S-adenosylmethionine carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_14699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000043">
        <property type="protein sequence ID" value="KAJ5079036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUR5"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="110"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="223"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5079036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="412" mass="47797" checksum="8E9208F3504FD91E" modified="2023-09-13" version="1">MNKTNEEKEIKKEFEPIKHLIAGGVSRIVSVILTAPFDTMKTRVQFHGSHLKSRGYMKGILASLVSTVPSTALSFFLYHYVKTQNQYKNFDEDILPIHHSHFHGLFLHAKNFLINSRPFLDAALARMIVLSIRNPIEISKQRMQLERTALIPHMTLFQTLLYLYRHYGISELFTGYSAYLLRDIISTPIYWFTYDYIRNFPKSGSNKKLNSNLKNQKEKIQKIHPIKHILSVSAATIMSTTLTIPVDVIKTKMQTRRLVENGDKKYSTIMQTAKTVYQENGVKYFIKGLGSRLFSVLPSSIISHFVYEWILEIWDHYKLILSQKMSSFYLSSTLSKGSRISILSSPYYYQENSSFNPLDYFSEHFHSKKKNSNLNPNSNSNPKNILSSLIPFNLTSFKKFPITLNQRFLNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUS1</accession>
    <name>A0A9Q0LUS1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_05058</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUS1"/>
    <dbReference type="OMA" id="IETWART"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5078270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="117" mass="13531" checksum="02E20241E167D719" modified="2023-09-13" version="1">MEPFFDFCPVCHNYLNYTSIQSNSIICDVCGYETDVIDLDGKTHQSIHHLEDEINFLSDEAEDLEEEKESRSLINELCPKCGHNKLLFNTAQLRSADEGQTIFYECPKCHYSWSQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV55</accession>
    <name>A0A9Q0LV55_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rho-related gtp-binding protein rhoq</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000025">
        <property type="protein sequence ID" value="KAJ5079592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV55"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="73" mass="8654" checksum="C7D10F7A780B770D" modified="2023-09-13" version="1">MFSQTQKGIKTIFDDQAVRVDFKIKCVVVGDDNSQRTEMLYNFKVDEFSDQEIPEICENFVVEIESQEKEYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWK9</accession>
    <name>A0A9Q0LWK9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_04236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWK9"/>
    <dbReference type="OMA" id="HEVKAFD"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="142"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="357"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5079215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="576" mass="66918" checksum="150D9954F6362C32" modified="2023-09-13" version="1">MSSKKNRKHKKRKDLENLSEEKFDKKFKEKKNKKNENKNENEQNQEELDQNYTENIFEKINKETSQNENTNKNQTIRLPLWIRKGKSITTNLQEIDETKSKEVFFGVSPIIQETLREDFGITTLFPTQYEVIPSIMETIKNSHFLLSSNDICVQAPTGSGKTLAYVIPIIQSLLNRVIVRLRAVVLLPTRQLVLQVRNVFEKFCSRCSLKVVSSVGESSLTQSARMLIQNNESNNEKENQFANTSSKVDILICTPGRLMELLQNIPEFSLEDLRFLVIDEADRLLTQSYSDWLYRINTIIKSSQKTTSKTRTDLISVKKMIFTATLTKNPEKMSSLLLHNPLYFFASSNLRFKIPSSLQQYYIICQEEQKPLYLYALLERLSIQNKEQTLCFTGSVEATHRLFYLVKLMSKEKFKVQEYSSSLNSKKREEILKKFHRGEINVLVSSDIMARGMDIVGIQNVINYNAPTFVQNYIHRIGRTARAGRIGKTYTLVTQDTKSYFLRMIKRKIVHESPILKENINQNVISELEVDYENNLKKLKIMIDQENIATSNFSCVNNQDILKETIRKQLTKTIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4E3</accession>
    <name>A0A9Q0R4E3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adp-ribosylation factor f-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_03133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4E3"/>
    <dbReference type="OMA" id="LIDQMCL"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="177" mass="19895" checksum="77071A81706E5AA6" modified="2023-09-13" version="1">MGVCESCMKKADPFNIIMFGLSGGGKTSILYKLKTGTTVEPAITSGANNEIIKVENTEFHIWDIAGNESSQSNWKFFCNFPQAIVYVVDSTDSQKILKGKEEMRKIVFQPDFNKLPLLVFGNKSDDQNSIPINQVMELLSLNEIQDRQWFLQKSSSVSGEGLFEGLKWLSDILKMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4K1</accession>
    <name>A0A9Q0R4K1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Condensin-2 complex subunit h2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_13272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND2 H2 (condensin-2 subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4K1"/>
    <dbReference type="OMA" id="FDPPEHK"/>
    <dbReference type="OrthoDB" id="10038475at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051306">
        <property type="term" value="P:mitotic sister chromatid separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031737">
        <property type="entry name" value="CNDH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009378">
        <property type="entry name" value="H2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031739">
        <property type="entry name" value="Ncaph2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14324">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14324:SF3">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16858">
        <property type="entry name" value="CNDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06278">
        <property type="entry name" value="CNDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin II complex subunit H2 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin-2 complex subunit H2 C-terminal" evidence="6">
        <location>
            <begin position="514"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="691" mass="80417" checksum="0CD1567C5CE825F0" modified="2023-09-13" version="1">MEDFDNREKKYSHLLKPIRGLAENWNIDIAKELEEYLTELESIKFTFDGGKTHLNFAEAALLIQGSACVYSKKVEYLYNLLYQTLDLLTEKRKNQKSKNLSNKEDGDEDMNLENEEEEQFLVLDDNLKIDKNIDLEDSFDINQILGISDRTTNRTRNKTKITENKIKLLSRTPIYLLGSTENQQSKANIEYYMTNCLIHPTGTLLLDERDLLTFGSELNSLTNQKINRSFLQTPKNKTAFKDLQNKEEQKQNEDNKTQEEKNKEKNEESESDEADLLDDDSDEDEVKTDQEKPKENIIETVAKNISTNILSTLRKPRSETKRDKDIDMDGKTRKGLFMKGSKQLDPWILLDPYDSSDLNPKPFAKGQTFRVPKLSEYYQIKKSQQTKGITCFGIHQEIEIPKNRKDLKNLYFPEFEALFQKERQNILSHFKKQKKKLGKEITLTDEKHDEMETALVGDLIMDNSDFSENDVEYPDQDDEDMNIDLGSEPDDFEPPKFAHEIEPIALDDDVHVKTYEDLCRDHIENFLSNAAIYVQETDLTRRVADWQSKITPLLEEQNSRSNFDIHEYGNLILDKFESNLNGNGWKKESIDSHSIFTGLPKFDICRHFLSLLQLVNNENVQISQENQGFDFSSYDPVLENDNSFQVKILTKQFAFEKISNSDPQNDLFVLHDEKSKKGRTRRGTGKRKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R563</accession>
    <name>A0A9Q0R563_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R563"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF36">
        <property type="entry name" value="CASPASE FAMILY P20 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040291536" description="F-box domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="392" mass="46373" checksum="E48FEFDFDCFC9A90" modified="2023-09-13" version="1">MLLFELLIYIFTFLPKSKLCITAQVCKKWKEASFHASLWREIFIDQQKISRFQLSKLFSRTKQLRSFILHWPKALTSKMSIDDILSLISKKCPVVQSLRFSQMFLTFNLRNELTNMKKFQNLTDFRLISCKLFSNLQIVSQCRKLKVLHLETIGLANLDKEFSELVELEELNLGFNNFNTIPPEILKLPKLIKLNMDSNLISSLDSPEIIQFIDQLEYLLLSYNQISSIPVLNNDPKLIKLDLSFNRFSSIDSLLQFKNLRMLNLFNNELTQFPKEIHQWKFLKKIYLSFNHLSQVDSITQLENCTKIWIDNNRITHLPLQFLQMKKLKLFNCSYNQIQIFPIELALCQSLEYLTFSENPWIDQEISHMAQLRATREEIQRYFTNSLGNDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5A2</accession>
    <name>A0A9Q0R5A2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5A2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="394"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68617" checksum="BB1D2C969D8E5DDD" modified="2023-09-13" version="1">MNEILFFGKNQYPELFKNESYSITKPIQFKFENENENENEKQIKQISTGDFSTIFLFKNGKAIEYLNENDSNQNPKKIQIEENIQKVTVGVDVEAILTKEGNVFAKGYNINPDNPNEFINISSLIEDTNDRIIQDIVSGDSSIYLLTSNQNAYGIGSNYYGQLGFDSETLETTEKPILMMKNVSKIFSGNNSRSTFLLNSNQELFGCGWNEYGKLGLGESRKEETIQKLTKIQNIPKGKIIDIQCAYSHSVMLIENQNQNPKRKLYSCGRYFFNGLGQDEDTYEFTEIKSSLFENYDNIREFSVGCFHTLILTSNNKLIGFGSNSYGQLGTGNTNTQSIPFQSELPKLRFNENISNYHISCGYDNSFLYYSPFISPFSNLEEDLVKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVKDYSEISNKSFQIFEYWIYSNQIKDGMKITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5D7</accession>
    <name>A0A9Q0R5D7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5D7"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="486"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69691" checksum="B8DC9C845E00C037" modified="2023-09-13" version="1">MNDCLFFGKNTRPILIKNEPDKITRPIQFKFENENENEKQIKQILIGIFSTIFLFKNGKAIEYLNKNDSNQNPEKIQIENIQKVTVGVRNEAILTKEGNVFAKGKYINTDNPNQFINISSLIEDPNDRIIQDIVSAWSSIYLLTSNQNAYGIGSNEKCQLGFDSETLEKTEKPILIMKNVSKIFSGNSSNHAFLLNSNQELFGCGWNHYSQLGLGESRKEEEIQKLTKIQNIPKGKIIDIKCGYAHSIMLIENENENPKRKLYSCGFYRYNEIGQEYEEDSYKFTEIKSSLFENDDNILEISVGRDHNLILTSNSKLISFGNNWYGQLGTGDTKSQLSPIQIELPKLRFNENISNYHISCGVDSSFLYYSPFLSPFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIEITQEIINEIEIGIDYFQLNQTNPNLFDLLINKFNNQNQNKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5G1</accession>
    <name>A0A9Q0R5G1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tenascin-r</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5G1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040216565" evidence="3">
        <location>
            <begin position="18"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="443"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="880" mass="97439" checksum="9D71AE7E1F6A29DC" modified="2023-09-13" version="1">MIKTLLLLFLFFNVVLIKSIQNQEEAMIKKGLNEIYESNLIQTFNFGSTNPFSLSIYGDCLVIGIPDLNQLFVYRYNGTHLNSQINLTAPGTTKLGFSVSLYENVLAASDLQSHRVSFYRYNGTDWNYEGYRYESTGQFGNSVSVYKNVTVIGAAQGYSVFISRFNGTDWVSDGSFVGSYGSNLGYSVSVYENLFIAGAPDTKQALIYEYNGSAWNLNTTITQLSSQYFGTSVAISDGVLAVGAWGAKTVSIYRLNGTNWILEKTYSGGSITLGWRVLFFQDFLLAGTYFNSNAAFLYRYNGTNWNTEKTFSQSGYFGCPIGISENLIAVGIEGTSDVFVYEYHLSQVNIINCSSFFSSFDCYWDQPQLSNLKYQINYGFDWIDIESPNLLNGNVYYKEFDSYYANITGNEDYSIQIRDCDLISNTCGEPSSPSINLTTRIDSVQDFQLSNPTNDSVNISWNHPNVAVVEGIPHLDHYNISYFKQSEPGVIAYVSIYNSSISYLLNTLECITDYNISIWGCRTLECQGEDQGDVVESSISTIFGEVSDLYCSISNILEVNCSWNSPINCGIPSSYNFTYQATSQDDSGNSQQNSTNQNFSAQIPNQEYQINVSACDLNDKCGLISTISITTDNLTAPNINNLTSRIEEIEINFTKVPYSNNYSISLNDGIDWQNFTKLNLTGNEGIGTISGIGGNIQFNISVRGCTDLNCQTLYLGLPSSINSTKAILGNITSLVCESLIYGFQCTWDQLILSNGLQGYSFTYGSTNICLSKSITNFSVSGLIGGIYYPISIYSSANESCSFSEYSGFTSTTSITTLFPNQTKSSSSNTSIIVISVVVPIVAIIGIIIAIILIRKKRKSFKTILKQREKELEKTGGIEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5M5</accession>
    <name>A0A9Q0R5M5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAj domain (Prokaryotic heat shock protein)-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5M5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="542" mass="65058" checksum="E6B600844E0FA9D7" modified="2023-09-13" version="1">MVDWFNLNTKDDVEKNTRQNLQHRVIERLVYAISQHPHNFTIQHKSIDLLGSLAFESKENRNKILQTDGIIEMILTAYYSNTLNRNQEFDQLQLNSGFLLSYFFEYNKEIILEIYNHINELKKTNSLIVEEKNLFISILRILKEIKKEKIKETINYQSISKLDFQKILSNNKDFFTQHDDPIHLNFQILDASRFFYMTNEKDLINEATQFRLHILQNLQKEKPNEILFKPNLRDLDFHRIKILISTYDVEQNPNEKINKLVVSFFQNLVFDQNSIDLNFQILDASRFFYMTNEKDLINEATQFRLHILQNLQKEKLNEILFKPNLRDLDFHRIKILISTYDVEQNPNEKNNLVVSLFQNLDLIRIIFQILDRSNSSNLKDDPKTKFQATQFRLHILKILQNLQKEKPNEILFKPNLRDLDFHRIKILISTYDVEQNPNEKNNLVVSFFQNLDQTLKNKKKIFLRANQKKAQELSQKWELICTQLPNKKPNHIQIQIQIQNQNQNQNQNQNQNQNQKQKPKKKLKQKQNRKRNQKQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6H3</accession>
    <name>A0A9Q0R6H3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5069009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6H3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="262"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="482"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68356" checksum="E567BECA35F52465" modified="2023-09-13" version="1">MNDCLFFGSNNHPKLLKNELNAITKPIQFKFENENENENQIKQISTGYFATIFLFKNGKAIEYLNERNSKRNPQKIQIENIQKVTVGFQNEAILTIEGNVFAKGKNINPENNPKEFMNISLLIEDSNDRIIQDIVSGNNSIYLLTSNQNAYGICSNQYGQLGFDSKTLPKTEKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGCGNNDHGQLGLGESRKEEETDKLTKIQNIPKGKIIDIQCGSNSVMLIEDENENENPKRKLYSCGISLYNGLGQTENTYEFTEIKSSLFENDDIIDFSVGNSHTLILTSKPKLIGFGNNEYGQLGTGNREGQLIPIQIELPKLRFNEDIYSYHILCGNENSFLYYSPFLYFSNLEEDLIKLFRRKEFCDISFKTQNGEIIEAHKLILQTIIGQDENQIEQLKQIISKKSTKEANQIFEMIYSNKSTINPKLYEEIEIEFNLFESIEELMKELIDFEKEKDIIIERKEKQYKFPKLILIMRSELYREKFLSVTEGDSTKFTDYSELSNKSFEIFEYWIYSNQVKEEIEITQEIINEIKRGIDYFQLNQTHPNLFDLLINKFNNQNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6Q1</accession>
    <name>A0A9Q0R6Q1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Intein-containing hbs1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6Q1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030908">
        <property type="term" value="P:protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="698"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="303"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1129" mass="129823" checksum="B80068F4E215F21A" modified="2023-09-13" version="1">MSRRRQIIISDDEFGSYGRKYDYPEDNSFGFSPSIERFMIDPNQEGVEISLEQYDDEQNNDQSNSNSEDIDINEQEFLEDIVTIKDFFENKFTEREIEDALIESDYNPHDAIELLQDFLNSQKNNQNNQTQNQQDKQEISNPIAINGKKTRNQGINANEQLNKPQRNNGKKKKKKKKKKKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNKNQNKIKNDIQNQIKNDIQNNIQNNIHNDIHNDIHNDIEKDISFEDGFGFEIQTVYKKSNKKRNKKKKNNQNPNTKKQSSLMNIANISLDSPQNQKNQKNQNQKNQNQKNQKNQNQNQKNINQTNQKNQTPKINPKTKNQNNQTPKNLNQNNQTPKIKNPKISKISTPKTPKTPKTPKTPKNLNSEQSTPKKIQHQRSKKNKKLIVEITEKENLQNVNKKEHLNLVVCGHVDSGKCFKKNTEILMSNGQIKLVQDIKQNDEIMGFNSIPRKVVNITKGHGELFEIRQSCGSNYTVNKHHVLTLAARSTFSREYQVVDISVRKFLTIPKNQRKNFYGIQSSVDFPTKSTSQNPFEFGKSIGKQICKLIDNMDQEIPLIIPDELKSNSVYIRKNLLEGILDSLYLYYNTNSNSFLIPLKQKINTEIYKDLLFVSRSLGVECISRENEIEMKYNIFLQDKERNFNTITMSELEIEFVGEDEYYGFQLDRQAKERFFLGNFTITHNSTIMGHLLLDLGLVSQHQLSKNERESEKIGRKSFKFAWFLDEHEDERSHGVTIDVGVKHFETKNKSITLLDTPGHSDFIPNMISGASQADVAILVVDADVGAFEKGFFYGQTKEHVQLVRSMGITQLIVAVNKMDCVDYSNKRFDEIKSKLQVFLVKIGFQQENIQWIPCSGFEGWNLFSNQNFSKEILEKTKWYNGNPLVDAIDSFKSVARDLEKPFRLCISDVFSHQIYGLTVTGKVESGNVMVSDKILVMPIAQVCTIKNLKLDQKDVQFAQAGDNIQIGISGVDESLLSTGQILCDPEFPIPIVTEFKAHILTRDLPNPIVRGSPGILYSQSLNESAIIKEIIGLIDKTTNQLLPKKVKVITSHSLAMVLIETSRPVCLENFENMKQFGRFAFRFQGKTVASGIVKEIMTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7Q7</accession>
    <name>A0A9Q0R7Q7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Replication protein a 70 kDa DNA-binding subunit a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_02338</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7Q7"/>
    <dbReference type="OMA" id="CATISFM"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003871">
        <property type="entry name" value="RFA1B/D_OB_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02721">
        <property type="entry name" value="DUF223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication protein A 70 kDa DNA-binding subunit B/D first OB fold" evidence="10">
        <location>
            <begin position="131"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="12">
        <location>
            <begin position="247"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="11">
        <location>
            <begin position="413"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5069761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="564" mass="65566" checksum="9C10C001B64FA0BA" modified="2023-09-13" version="1">MDNLNQFDCVVTNFQTNEQGLTVYVSSGDNAGTVTISEEIRERFLKFVQEGVQLRTLLDTSKNPLEIVDFQFLDPQIQQQYEQQIQQQYPEQQQQQQPQQQQQQQPQQQYQQQQQYQEQSEDIDGHVTPFKSINPIDQNFLIKARIISKSEIGTFSNTTREGRMCSINLIDEEGSEMKATMFDDSIDKFYEQIEEDSVYYIKNGKMKINNSPVQTTIFQMTFSNRTVMQKCEDDGSIPKMTFSFTPIGKIKELKSQTLVDIIGILIEMGNLENLTTKDGRAVAKRRLVLIDQTSKIEVTLWKKSAEKVEDLIRQHQTPNAPNVIAIKRGKVAEFNGKYININDLSQIFWMPNCPEAKKLIQDSMQIHNQKDQMESLSGGEFNWYSHKRILISDIPNVGKGKTESETVIISGVLAHVQHKNIDRLFYPSCINKNCNKKVQEREGGWYCPKCNQIYPKCGYRFMSSVCINDFSDSYWCTIFDNQAQKIFMTTAEKMRELILNSSQLEIQKYFEKFSFQKFLFRIQLKSDFYQDEEKIKATITGSCPLNEMLIDESKYLIENIKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7S7</accession>
    <name>A0A9Q0R7S7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7S7"/>
    <dbReference type="OMA" id="WFYEERI"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="559" mass="66311" checksum="52F02425315559C2" modified="2023-09-13" version="1">MNQILFHLNLIKIKSYSSKTKTKKRKKKRNEEEKRRKFLKQFKGRLFLFLLLLFAIITIFIILINVYIDTNLSSNILYFFIPLFISILITIPFLFYLFKFLQDFKFSIYGIGTAILFIEVLLIGLRIETTIKGSWLLIFIPFFILVGFIIIYYIILILKKNDLFYKLLVLLSIFVLFLIFLILLGLRLDETIKSNYGIIFIPLFLINLVTFIILFYLIYREPKDEDDAYLFDGSINRISYAFIPIYALSAIKIGKEHLNELKKGEYCEFAEYLKLAPEEENLILEMLPEEVLLYIFQFLSPGDLIRVASTCQTLNELSEDTNTWRNISYNYNQFFLLNKVEVQRRPYRYQENQIPIYGIIKETQLLTDNIDAFVIAFLLNVHIDKKQSSNVIYVFIPFLLPVFIFIILFFILYKYKSQFEFSIYGFAMLILFIQLLLIGLRSDSTIKGSWLLIFLPFLIFFVVLIIGSIILYQKENADCIATTPITIFIMILLFLIFLGLRLDEKVTWNYGIVFIPLFFINLFFIILFYLWIFCEDDVSGIFFFFFFFCLLKFSISLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R889</accession>
    <name>A0A9Q0R889_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R889"/>
    <dbReference type="OrthoDB" id="1510206at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016615">
        <property type="term" value="F:malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="237"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="408" mass="46894" checksum="04A39EA302DE2647" modified="2023-09-13" version="1">MSHDLQKKIAYTCFAINAVVFVTVFYKQYKKGKDNKDDQDNQDNIDNKDDKDNKDNIDNKDDKGKYNKDNIDNKDDKGKDENQNENENENQNVNENENEFEFSKFVEFPDLIHICFTNATNPLAYSLIFQVIGGNLFTDTPLAIHLLDQKENEKKLNGIVMEIQDCAYSSVKQILPTSNAEEAFDGCDFAFLIEPYKEDEKKNDLDHLKENAILFKTYGNAISKKVNQDFRAVVVENRAKTVLSKKFLVHPESIQDIFVWGHNSSLTKFPDFSNACYIQNGEEQKFVNSESESEQNDFVNKFNERTQLIQQKKKSPNYISIAKATCDQINDWIVNPTNKLTSVGVYSKGEYGVEKGMVFSFPCFSNGSDWNVKKKISLSNPAVNSMNLSKQELKKEWEEILKLNNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8N5</accession>
    <name>A0A9Q0R8N5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-related protein rab-5c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8N5"/>
    <dbReference type="OMA" id="TSHATYF"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="196" mass="22341" checksum="D0DA7CE67394AF59" modified="2023-09-13" version="1">MSEKPSIVSKVVLLGHAAVGKTCLVKYLMTGEFERDTQTTSHATYFVYDFEFTEQIIKLQIWDTAGEERFQELAPIYYHGAMGAVVVYDITDEYSFTRAKFWINELYRQGSVNISIILVGNKKDLEDKRVVKLSDVENFANENSIKHIQTSAKTGENVENTFRTLAHKILQSGQQTKTKEIDLNKKKNEGKKKGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8N7</accession>
    <name>A0A9Q0R8N7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8N7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="370" mass="44248" checksum="BF2284A5028D6038" modified="2023-09-13" version="1">MRKSRSREKMSKSQSQEGIVEILEETGNTHRYIFSYGISVFILWFLNILNQFVDMGSTKMQYSPKNWFIPGQEMFFVWWILDVIFIFFILFLVFTQDTQTRRRAVSRVYIFFPICIVLDIVHMFLWQAGKIKYTLIPLTLLLVFTGTIYIRLGTMGRWRLKQGIAWIRQLRRKKYQNDERSDQNPKYYFANDLENFIETQSENQDQNSGIDLDDDKPEDAILLDEMNVAYEPEPDYASWGELLFVHGPFSLFLSWIITLLLFNILMVSYHVDPHNWLSTKSGCIFLIFLSFIILLFLIYFFRDPFFPWIYLGLYLNSIVYNRNETSVFVSALICFIIVIIVSVFVFWISFRKRKRRKEESMSLLNEKYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8V4</accession>
    <name>A0A9Q0R8V4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8V4"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="143" mass="17162" checksum="4AB45D50C3037269" modified="2023-09-13" version="1">MSNKEKITTRSKSKRKIETYKLEKDPQALLLPTESKRILLIWLFYNIQNPYPSKKEKQELCEKANMNLDQVNHFFINARRRILRPIVEAIQEEEKNKESPLTHQMRLKSGRKIPVSEIDFEHSPSIKDRDRYQSFFQNQNETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8X8</accession>
    <name>A0A9Q0R8X8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8X8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="275"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="651" mass="75834" checksum="5C198834E6925241" modified="2023-09-13" version="1">MNEILFFGSNQLRKLIKNEPDKITKPIQFKFENENENENEKQIKQISSGYFGTIFLFKNGKAIEYLKENDSNPEEIQIEENIQKVTVDTNDRIIQDIVSGLSSIYLLTSNQNAYGIGSNNYGQLGFDPETLEKTEKPILMMKNISKIFSGNDSFSVFLLNSNQELFGCGYNYDGQLGLGRSTQIHKLTQIQNIPKGKIIDIQCGFFHSLMLIENENENENPKRKLYSCGYYEYNGLGKIHNTYEFTEIKSSLFENDDILDFSCGCVHTLILTSKGKLFIFGGNSYGQLGTGDRKYQKVPIQIELPKLRFNENIYNYHVLCGYSNSFIYYSPPSFSNLEEDLIKLFKRKEFCDISFKTKNGEIIEVHKLILKYRLNQNQNQNQIEKLKEIISTKSIKESNQIFKMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSISKLSEASDSKECIVVVVDYADNIQEFRHQWTTEEYHKAKFWSLLCFSILYGEQILYYDVISVETEKNGFLVQPSIDIFSKFFTQKIKEGKLSKKQNNWTSILTVVDISKIKMLEKFVILNILKLFGSVFSCLISRNSFRISTLAKLFGIKNRYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9B0</accession>
    <name>A0A9Q0R9B0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9B0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="96" mass="11149" checksum="5DBE32C8F2CC05CE" modified="2023-09-13" version="1">MVESTQKTEQIDPEDFQKTETDFDSTKKELEKIILQSKDLKEKHDTIKSEYENRVSKRNAQKRNKIILASIPVILISGSLAAKYFGLIDFNFKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9F2</accession>
    <name>A0A9Q0R9F2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9F2"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="DnaJ-like protein C11 C-terminal" evidence="3">
        <location>
            <begin position="395"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="513" mass="60245" checksum="1E34F91A798B9B2C" modified="2023-09-13" version="1">MNDNQQNFQVGFFDKPIFELIKNNQTENQNENRNENQNENQNQNFSFPKNNIFIKIGLNLNQFFSNYKKQNFWNQNVKRQNPIISKIQLQNNIEIKPTNKSQILIQSLIKKSPLLFEPKFNVLFGGSISKNYEFNTQIGFSEEKTPKIKLITKQQLPNSITNTISSTLNANRNDPKKPPLMINAHAYKSFSKIPYVNLKDPLLHLRLESNYLLPLLKLQHKNGAVEFDFLKGKFMFSHEQTDSKTRFFFKTSFTHPFLNPSLYFDHLIPRFEFGFYQNFHNASKNHKFEFSNTNFIQKYVGLQFGIHHQITNNTTLSGFFSIGLKGISLNLGFDSNKFHVNIPILLTDKLDLVSFLSYVVIPSTIFIFVKKFVINLVWKKLIRKNNEETKDEDSTENKNQQISNLYSDLLQQSVNIRREKEEKKDGLIIQEARYGDLKSDKYIDVTSQLQFQVEDSKLKIYGDYPKSKLFLFEDPSPDSSKSLWIRYLYQKKIHEATFKDLEEVEIPNENQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9I2</accession>
    <name>A0A9Q0R9I2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4e-binding protein thor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF4E-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9I2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008606">
        <property type="entry name" value="EIF4EBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12669:SF12">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05456">
        <property type="entry name" value="eIF_4EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="138" mass="15541" checksum="E58362C66ECD9039" modified="2023-09-13" version="1">MSNEQNKTPTIRIKGKNDEILEINLPPNLSKTPGGTIFGTTPGGSKIVYTRDQLIKLSTSPLSHTSPPNIPKIAGITKDFNDSQSNIDQDQMNESNLVNSDVIDEYEYEDENENENEMEFENENEKGDQDTEEVFKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA96</accession>
    <name>A0A9Q0RA96_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA96"/>
    <dbReference type="OMA" id="WHVRLHQ"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="68"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="225" mass="25556" checksum="EFCE782809D06D80" modified="2023-09-13" version="1">MSDSDSSYSTSNEDPETSSGSEIIDDDDDEDYDSDDDFGFDAIKPTNEKREDKIDPVEDELAKRATTVATKALVKEFRAMKALGPEQGIKTELVKDDLFHWHVRLSDFDPKEGLQKDLLKTKDKNILLSVQFPEGFPFDPPYIRVVRPRFQFLTGHVTIGGAICTQLLTKSGWTPAYSMESVIIQLRAGMDEGKARLDLNRHDEYGEMEAKQAFMRFVSKYGWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAI8</accession>
    <name>A0A9Q0RAI8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mtl1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAI8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="299" mass="35901" checksum="949F7CFB3799B8E1" modified="2023-09-13" version="1">MTNQTETGAWGGKGGPKTLTGKESLNRNYNQNLIRNYNQNQNRNYNENQNQNQNYNQNQDQNQNYNQNQNYNQNQNYNQNQNYNENQNYNENENQNQNYNENQNYNENQNQNQNQNQNQNQLNQNQLNQNQNQNQNQDQDENREPHIHVWVFENEIETKIQTLFTLLEYFTETRTVIFAKQEYLKLITYHLRTNDWPGLYYDNNKKDGILKSYEEGFDPILVLTENESDLITNRSIKIPYCVIFWDVLSSETMINVFTKKEIGHLYIFHPLFKTQFTDGIIEMIKGFNEKPEENLLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAJ8</accession>
    <name>A0A9Q0RAJ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine/uracil permease-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAJ8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="97" mass="11349" checksum="AC47968CC35FE4FD" modified="2023-09-13" version="1">MKRKKYTFKPITHNFISTPSRDRNLKFQDLIETIPAVVCIIAIPELDSIIDGVTSGYFVLILLWITGKNRMWKQIKFPMIIIFIVSIFGLFFPRTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAS3</accession>
    <name>A0A9Q0RAS3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAS3"/>
    <dbReference type="OMA" id="WIARHAN"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="208" mass="24475" checksum="096203B88A06B571" modified="2023-09-13" version="1">MKRSIWIIRHGERIDDVDENWEKTAKNKYDPTLTENGKQQAFKTGKRLKNESISLIFSSPFLRCLQTAKAVADQINLEINCEQGLSEFINKNWFPSINDIKLELEFFQNQNQFEKINQNYQSFITISNPETIQEMFQRYQNTANKIIQNYQNQNILFVTHGYGISSIVQLFMEEDFISELDYCSICKINESNDGNFEIEFINETSHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBC0</accession>
    <name>A0A9Q0RBC0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase 3 regulatory subunit b alpha isoform type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBC0"/>
    <dbReference type="OMA" id="LKFAFRM"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="183" mass="21210" checksum="FEDEF9B8757D04F6" modified="2023-09-13" version="1">MGNTAPYKVLTQTELSELQENTNLSQKQIISLFKRFEALDKDDTGIITYDKLFSIPELAMNPLVLRVIGLFDPKEPDPEKIQFNFTQFIQTLSVFSEKASNEEKIRFAFQSYDVSNSGFIDSDNMKKILKFFVGDCLNEKQISEIIQKTFEEYDKEKNGKISFEDFQKIIDIDDICDKMTILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBM3</accession>
    <name>A0A9Q0RBM3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBM3"/>
    <dbReference type="OMA" id="SEMTHVA"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="184"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="464" mass="52833" checksum="8888B419231CA708" modified="2023-09-13" version="1">MNKLKLTTLSNGIRIATFPLKTPLTTIALASFAGSRYETTKELGIYRILEKMMLTKTKKRSTEEREETINRLGGYIDTKISAEAFLMHGSVISNRSDLLIEIFQDSIQNLVHSQKEINSKIQQYIEKSKETRLIGREIIDDLVHAAAYAPKKLKILKANEYHFSNLGLAQNSKSLLFSEKKLKSITSSKLKNAMKKVFYGENMVFSNVGMDHDLFCKKIDNAFGKMPKKPPQNLPQNRSSYKGGYINYPQKIVDDQNTTVYIDGKLPLNAEMSYLGWFYPGADLFSDDIFAYFVLQFIIGDAASFSSGGPGKGMYSRSCRNIMSKHFFIDSIEAKNFSYSDSGLFGIVAGLNSQFLENGCEIIHNEFLQLANVPVPNQELERAKNRLKMMLFMILEEREVFAEDIVHQILFYGYWMNPDYICKKIDSVTQKDILRISNNCLNSPLTLAAWGDTTSLKNYEKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC43</accession>
    <name>A0A9Q0RC43_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beach domain-containing protein lvsc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC43"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="80" mass="9130" checksum="1B32E839D3C9661B" modified="2023-09-13" version="1">MTLLHCFSSWFLTNDGEFLVTGNRDGFVRFIFLKNLKIFRKFSFGKSITSLILNFDEKFIVGGLCDGHLLIGNLKNPVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCW9</accession>
    <name>A0A9Q0RCW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCW9"/>
    <dbReference type="OMA" id="ITEMRIC"/>
    <dbReference type="OrthoDB" id="18598at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041245">
        <property type="entry name" value="CARMIL_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17888">
        <property type="entry name" value="Carm_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARMIL pleckstrin homology" evidence="3">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="869"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="934" mass="106810" checksum="47E883681D115E28" modified="2023-09-13" version="1">MAAPSFKIVTVEDFHFVHNLMKSKNEKTHFFVWVREKKVNEKIYDRLVIVTKYRLITVSKKQDNLKIDQNIHFFDLKEVASVNPLRVIISTSNSKIDCYTDQADQICEHLLTNYLKVTQGFSERNFIKFLTNPPDRLGPFNYKPKIALGFIQMYKAWCNYYELEPNRNFLKYLTNEIIQNENPENQVNFNLSSFPGFDNLLSNTKELNPIKDTLKYNRYFQTLTITNIGNRDIISPISESISETMNITKLVLTGSTGTGGLDALGKALEKNQKINITYLDVSRNRITASVLKHGFGMGVEKMNSHSLSYLDLHGCDMNPSTMLHFFKHFAKNTDHCIKYLSLSNNQFKKKGSEGFESWIKSLNQNFLQELYLASCSLDFSIVGRAIKESNSLNNLRILDLSNNPMHQGQETALYSFIQNNNSLKELDLTSTNIFPKSAAQLIYEVLVNEHYSGFILRLAKNAFGPKGAEFISETFHSFPKSSSLEELILDDCDFSAEGMNSLFGNSERGIFLNKSLKKLSVSRNIEKNKTKNLQPETLVNLLSNSNLECLRIQGDFKHSLGNKLSQSLDKMKSINLLSLDISENSLGDETLRKFAKILSDPSSKLLSLSFDKNQLSFEALQSFAYVFKTNYVFFDFIWPKFDITKLLSVSSKKEKKKLKQNVKNLKQEITQNCNRNNNKGLDVPKISSDFSQLTSSQSSNLQESTSIESTPIKNRLLRANTEFVSPSPSHDIFHTKRDLSEIIRENSQISETDKTSETEKSSEKEKLTPFKKPIIPSQIPKSTSKEQNLTDQQENQNQPQPQPQNLPQKNKNIQRHITIEKYDSKKDDLKNEKQNTPIKSRPNNPAPKLSGIKPQKPQSKPPPFRKPRNPNQNPNIKQNPNPKQNPNIKQNPKQNPNLKQNSNIKQNSNIKQNPKQNPNLKQNLTKSKTTSDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCZ1</accession>
    <name>A0A9Q0RCZ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Actin-10-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCZ1"/>
    <dbReference type="OrthoDB" id="3057171at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10169">
        <property type="entry name" value="ASKHA_NBD_actin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="182" mass="21115" checksum="92075AE74010450E" modified="2023-09-13" version="1">MIEEDIDYQAIVIDNGSFEIRSVIQFKKELLKIGIIWRKCGIISFYNELKIAPEEHPVLIADSPFNPRNLKKKIQEIMFETFNTPAFYLGNSGILTLYSTGRTTGFVFGIGHEITFTEPIYEGYEIYNIIDQYQFGGNDLTNYLIKLLKEQDYSFDKSSDIEIAKKILKKNYVIVLLIFNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD17</accession>
    <name>A0A9Q0RD17_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="WILALPE"/>
    <dbReference type="OrthoDB" id="10631851at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF15">
        <property type="entry name" value="RECEPTOR FOR RETINOL UPTAKE STRA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1321"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1350"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1379"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1601"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1701"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1760"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1795"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1830"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1459"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2008"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1459"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1496"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2021"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2038"/>
            <end position="2058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5076061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2058" mass="232016" checksum="06CB201A7ED108BB" modified="2023-09-13" version="1">MKRVGKIYYDKQTHSIKGLHTPVFLDLTQDRVRLRLLTMFLFLFILSIAAFQAISALFYQRSVVDDENPDTMTFTKFPDSEVYYNTPFTNVPNTRISNMFEIGLESKTVSISATYDPAIPFQSNQNGKTLIQIRDQEIYPVSFQGTTQSKTDEDGFTDFSSLQLNYGPIGAVVLNYSCESVWTTFTVYTKTNVSIINTTDLPPYSESGNSTEEFGVPLTVQPEVRIFDSEGNPLAGHYVRIYNNPNQFATSLYYQRFALFEGEVAGPSDENGTIKFTDFTVIGATTKDLYFAFFSERDPIMDPNVINWVYYTNNQTGIGTYGQPVIFSTDVSNVEIIIQPSENVTEGVPFSPQPKIRVTNSGGEGIPNKIVFARFKKKMGEIVSDVSELDNEYVKNLLNVISGKTDAQGEVQFENLTVGVEGTSNNTEDNSTAYTLSFICDGVESEESTNFWILSSVTKMVWLQNSTESSLLDGWQYSEKQNLSDLYGMFTPSPMLRVTDKDENPVAGKFAWILALPEDGNISSIDDMSEIRVDGKYSVSDLDGIISFPYLRIVSLYNSSKTRLKLVAYCDELIVESDWINITLGNSSTTRCSQLYFKSGNFTDYLSKPFHVGVDEPFNMTVKVLDFRGRPLANQTIRTGTQLFVETFDNFVPTSFMFPLEADNVTDEYGEANFTNVFFSGYTGAGYFFVYALNLEESYHWKTSNVEFDCLTEFTVHLTNNIQNIVVQVPETHVEIAKGFSQPIIVQVNDSDPNQKGEYYVDVITMEFPLYLIYAWITISIGPSEDLITPDNQFNVPGDMKFYRNPVKVNCSDTGTLNITDLQLLYPGEYSLILRVGGVFTHVLPTIIAYAPVEIIAITIPPNDSSQPVISGKIFDQQPEVYILNSTGGGVPNVFVVAETNETGSLYTDNIYTVAVSSKSDSAGKATFTNLRFRSVTEPGTYIICFSFYNSSDLTSPMIRNCSNQGINATTLVDHITLTGLPSAASPGVIFYTSPVVTVFDVNSSPLSGALVMAKFSSKPAGSGDKTIDLYMENYFGETDVTGRVILDSMYFYTNVSLGVYEIVFTCDGINSNIMEIELTNTVDKLEILIQPSPNITIGIPFPATSDFYVGSEVIGGQVAVQAFIKSGAPLPYKGITAVVGENAAKGNFALDVSRSVETTDGYGIAKFELKAIAGKPDYKYTIYFTSDGVQSKDTDSFSVFNPVAQVLIIEQPGIGSNDFVELDEKLPDQPLILVLDHDNKGMEHKTITVKTVQHGTISTSSGGPVSEPGGYYRFTDLKITSGSTQDYELIFIVDGIESQKSQKFNVHDPSSPDLSGFKKLKGLIILATLIMLFPFFGNSERQNRRWGMLLPFGVSIFILVLVGTIWGNSKDSLLKNGYVITSLIILTLVTLFSVGLLWFLIIVNLWADPNKWEFCPKRLKNYKNLVRRLLPIGSVRFFVLQRIREKFESDFKSEKLKWKEDQNEDDQKEKGKENEKEKKNQNEIELESDLDNKQNENNNNNNNNNNNENDDDIPIDSIRKKNFDDLNDQEISKLITNFINKDSEEKEEDNKTESALTRFGHKMKSVGGKVKSKISDLLASEENPHARFETKKDFFYPQRLFIAITLTSFIIFYMFLIFVKINSYIKYKVIIWRQEILELEARLQGFISQSKYSVENAFHTSFDLDLNFNSTSDFLPQNILRVVSFLGSVDNDKVDKYFEISLIAICVSSVLSAAVIGVLWYLIMKLYRQRIMRMRQGHKIFRQPMPPPAATSYSGIQGWLAGITFVLFVLIFLAIIVCLGFAPLRKFLWRHLWPILLGILLSVVIKAVIVALIKYFIARDGEIVHPRLFYLWDFIWLFLNIVSGLATAIIRLVVLMFANLAFFMRLDQPSLSGSLSILDSGHRSYVSVLQMDHKFNNPVVSLFIRGLTRGFKYRRQIQKGFLSKDGCCAKISKSELDIAMNFFKNDMEYLNALNKQKAALRILLLITLRNNPKVAKYRYFNVGKDDKFEKKIENEFEKLDKDVHGYLENLKKNSSSSDDDNNKENKEDNKENKEDNNDNNDNDDNDLQINEIDDQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD87</accession>
    <name>A0A9Q0RD87_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD87"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.20">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="820" mass="97961" checksum="0EA36F5096F8B3DD" modified="2023-09-13" version="1">MEIENQEKNTYEKNFHNFFLNQIFNLKIQQQENEQKQKTMIENLKKILHDYSWENIEQNESHIFQDSKKDRLENNPIRNNQIIYIIDDLHIFLFSKSKILSSLQTQLQNKNISINLLIFTHTPFGNLSFTKSQIKQARKNLKKTQGKIIFIDDLFIISELVPISSSLEYHFQSKKSFSHHKNKFRLHFLNIKNEPLFSCSLIMNESDLKLSEKFDLNVKIYSALSSFKIQEFIRNKFEINPLNFSRIFFCQVSIKNIPFLTTLAKNNLVLFGIMNNFHSFIVVFEPLTMFIGKVTLYSLQNEKILNDFLNSKNQISYDYLYFEEEEKEKVNEESNSIKSFIFHQEIFFTYQQIYKHFDEQEMEIENEKKSIPEFKLLEDIFLSFQNPIKFENENQNVNKINNFLDDQFMKYLKELNENQNLNENQNENQNQNQNENENENQNQNLNQNLNQNENQNQNQTIIIILKEIKSLKQKYKEFLSEKKPNKPLFISPLTKMITYKIMETKDLITRQKYIQNFVNYISKNLIIPPKKLRNKYKKLTIISTKKDSTKNINEIVQKKIVEYQLQILFRFDLIKFRLLQNPKLIETNNQFISKLVQEMIDLIEDFSFLIDFEEEKTGLSSFIFHLRSIYIENEFNSIFSQISEYFNLTFVSTIQSKIEESKIEESKIKESKIEESKIKEPKIKESKIKEPKIKESKIKEPKIKEPKIKESKIKEPKIKESKIKESKIPNSKIKESKIEESKIEESKIKESKIKESKIPNSKIQSKIQKSNLNLQKLINSNLFVQKTISFSKFKNNYKSNSPEKSKKEKEKSKKKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDJ2</accession>
    <name>A0A9Q0RDJ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDJ2"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="345"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="440" mass="51047" checksum="B260FE38A8634F26" modified="2023-09-13" version="1">MNLIEAVKKNNLELISKCIEDGQDINQTDKNTPLHIACDKNPNPQVIELLISSGAKVDSVNRNYPLHFLARNDSVECLKILLQKEVDANCKNKWTPLHFACYHNSPNVVRELIKFGVDLNSLANVNQKLILIIFYILIILFIQDNNSPINLAARYNQNYEIIKELIFAGCNVNLLNRENPIHRLFLEKKVDQRSLNLLLSSKCSLDEKNNETPLDLVQDGESKNLLDHYLSIIPDLRDLLERKEKCDLNIQCSDGEIFCHQMIFRARFLEKFNLEKIQTVLSKYKTNQVNEYLEFIYLGEIDYPKSFKLITEISEKFEIKNIENKIGILSLISDLTELSKDQKSKDFTILVSKKKICIHSTILLARSELYRGMFVSVDDKSNQVSDYSKLSFETLSILFNFFYTDSLPQKMKKKYKKELEVAIDYFQLNSNTNLKKLLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDM9</accession>
    <name>A0A9Q0RDM9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nnp-1 protein putative nuclear protein 1 nop52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10692125at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1421" mass="167036" checksum="406FED2AC59DB83E" modified="2023-09-13" version="1">MEENNNNNNNLENNETQIKKIISNKITEKIEISNIISEFDSNGKPILIQSKIQDFQTQENKFITNPNIAKNSKKITKQTLVYVSQGFVDFNLKIITNSLFVSAIIKLRKKKIKVISNSKKIYEVPFNENQKIFLHPKDFTLFAIQLNTSTSFVGSMETSFERDLFCHSFLSFLHKSTQKQDYNKPPIILSSYKFASNHLFEESILKLPVDSSSNSYDKFFSDLIFSKNTSQYLVQSIPNESPQNKPGEVFKLNLYNSFQENIGIGRILLFDDHFAVKISDQEFKRKYSSYSTLQFFSNQELFCRFYIDEHCFIVMKFDNEEKRNHFLQSFVSKSSKITEIFDSQQKTGNEFKCKVVSSESNESESCQITFDSETFDVQIGSDFQITKKYSLDQEISETDLQKDQKNSLNFSIGMNDYLVLSFDDPNQMQDFKSKFEEKRSRYFANAFDTSIEINQFDVDIRQEKSSNRNQLNISAGHLILASSSLTIIWKDDFILDSIQNIKVSKDEKNYPGFIILNLIKFKSACLIKFKDLESQHKFHSLITKLKSNTELFKEHQDHQYNVLFYSKLGKLQYSGNVYLRKDFILLLNSNGEEIKKQISNTQFSLHLNNNCVCGLFFKDIELLVILKFDRKEDLDHFIEELKIRKKMIIDKNKKKEIEKEIEKEIEKEIENENQNQNQNQNENQNQNQNENQNQNQNQNQNDINLDGLYLPFLSKKSLKKAECSFLNKQLETIDQGFLELDENAVIIKTSSQKLRKSYANKAKVSKSPKNKNVIKIDFMDGNSFIVSFESINQATEFLDLWKFQRKKNDELDVTPRKEPPIHSFSIKLITKDFVQIDSGFLKMKGETFLLDFEKQIVVKPFNPQTNILQISQNKRVIKISFSDGEEFMLVFDTEQQKVEFLKIFNQLKQELSNQKTRQFEPHKDIRTPFFSVNSPDEGRFLVGILAKDFEILEKAHLIIKNQKIKIKSKKKKIVKEQTDKMKLSFFSTNPNIVKLQFDSEIITVLFFNSEERELFSKRFQFQRSMSMKSLVVPQKQIKNSAEKLTEEKSTEKPEGVYEVNVLDSKFKKIDKGTLKINEKSIFMKTSKETISEPFSDQLKLFQNSEKGNIFKLELKNHKSFILSFDKSQDLSKFSKVYRFQRTKSLGSFPLKRKTQIKKGIEQKELSKTSPKKPVKAFSQVEHQRNLGNKKFQAYIIDNSFLRTDKVEMSLGDDFHFKTSTVNYHFEYYQKFKLMKHPKYSDILRFHFTEGSYMVSFQSEEEKNDFVKSLKEAKMSYYQKKQFEKEKQEKQQENQDLSEKRKEMARNDEIELEDFSFIDENISFFNATITESPQSPDLVNQEIKIEVSPEYFSFSTSNDVSKSFPFSDPLKLFAMSRENIYKAKLIFSTEEEFVFQLKELEQFEELIRRIKVYRKKEITQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDV4</accession>
    <name>A0A9Q0RDV4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDV4"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="449"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="788"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="892" mass="103538" checksum="58C900A503198DEC" modified="2023-09-13" version="1">MQEANKNSITTSSRNIIKQPNIPKEIPEQIKSILSKEYQTSSSILDKIIKTKKKISQKNPKYIEEILKKTNESSEELFAPKKPDSFKEEKQIDIIVNLEEKLSQEDNQKIEKLLNTVDGYTNNTQNFISVLTNVFKEIDDAFPKVNKQNLQISQHTQSLETFGTKKTFNPKKSQYQLLAAIFSILESNSVQGFTNQIKNEITDLIYEMNISFENLYINWIKVVYLLKENKIVSGPEDNVLISLETLFSYYIYTQNFKQQLTQTLLEKFLSQNSQLISKIKKTVFNLIDYNVPGKIQFEVFIQPLKILISELSEDSENTEEEAKTIIEEVRKKSFSTTLKSIILHYMPKEVKFEINQSLTAKDKDSELKRWFERGKMYLEHLLSEDDLYFLTAIFNKTLFLPFIKEAANPVFYLFEMFGESLNLILFTISQVVLSTVSAGTLLKEDFAGEFTKIYTFENGKKFLQEILSKPIIEYCKSNDSLDLDPSNANFEGNLEENTEKMKHYLQSFSKAILSSAQKVPENFKVISSLIKQDLMSRFPDNVISVICTFILSNFICEILKNPFEYEIINFEPNPKSKRGLENLSLVFETLSIGAAFGSNKKNFQPLNSVMIQQFSARSNFINSISGLKSFEYQVVKKEEVHEQSTKLKKIKPNSAMATLQQGILKKKALMKCFLDIGSHILITQNKSIDYSTNIGNFYIQKIHNQFRSIYQKMNKLNEFIDDLDMLLDNYQDKKEEIHEEKENQNPNQNPNQIENQNENQNEKNSLYDFNKMNQKQLIEIWNNLSEVEISKEGKLHFSNSGGAFSWKKRYFILKSNLLAIFQDKSHAKESNAKEIIVLHSSILIGYSNSISYYKKKVFQITRTDQSILYLCSDSQKENEDWVHTLRNARKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDY9</accession>
    <name>A0A9Q0RDY9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDY9"/>
    <dbReference type="OMA" id="ASELEYC"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="1"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="785"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1167" mass="139123" checksum="567E161353B1A6C5" modified="2023-09-13" version="1">MLSQYDNLFKLAKYFEHDPLLLDSAWKSANWIEFERTIKKEMIHDSQFVLYIGYLRFQKSQKNLSLILQNSFVNQYLNQYQNINQNQNQNQNINQNQYQNQNQNINQNQYQNQNQNQNQNKNQNQNQNQNQNQHQNQNINQNQNKNQNQNQYQNQNQNINQNQNINQNKRYQIRTRQTSSLTPNFQVKEFNTPNLQTSIYNKNFFANKKYPQYQKSKLQYHKQSPNLSSEQKTLISNEFLDHEKIYTKIRSLLLSEWASLPKQLDNLHIKFLQKLQYHHEFMESVALFPQIANAPSQEITNRLNYFFRTWQERLPLKCEDLMVWENVFNWRKQVYSYIWDFIQKIDPIFQNNPICIHEYGKMIAKIANIHQKHGAIPQCLNSLNKVFILANISSSDMVKNLKTKAKCYQQMPEKIPEMLDFLTEDNLSHFPDPNQRSVFKRLKAELLTRIGNYSEANKEFSESVQTSEKIGKNWESWGKFCDQLYTTTKNPVWGQQAITYYLRSVYLLNDKNFALIPRILYLYNHPEVFKLSFGMSMSISPFHLPLNLWIPWFLEILNGVFQKSDPQIYRHILNKIAAKYPQSIYYTVKVMIQILVIGKIKGKKFEEAINALNELMENLKRYENENFEIHQMYKFQVPTQQIDLLIRSIIANYHKDEEIMKMETSFDVLLKMLRKCKSLQDHVPIEKLSFIANSTPRTPKNSKNSFDPNNPKISSTLSLKECFERFLRFRYEKEPEFRMKRKSKNLEKEDEFLARFQGQELVEIPGQYLVLKLNPSQHVKIHRIYPEIQAIPNHPSSDRKIIFIGDDGKLYPFRVHKSSHSEIFTESRITQLLQFLNFHLDNYIQTAKRGIHFHASPVIAITKDTQLISEDSTKLWFEQVYFDYCTNTRHNMEPFLYHFENVVETGDPQKDLQNKINVFKEIQDLYVPENILHRFVFSMLSSVRDTWIFRKQFILELGLNYWLRFLFSSWEYVPNYYSFDSQTGQVEHTRIKIKIDENQVLRPLTQNSVAFRLTPNITNFMTQIGILGLFSTVLSSTSQCFSEKSFEFRNYMNILIQDQLIFIQLNKMQKIVKLQNLSNSNSNPNPKSTFYSFAKKQIFPYLTLTTPILEKVEKNVELIMERIAFFDPRKKQFEEKNQKKKSLKDLIQQCQSLEKIAMVNPGLFPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE45</accession>
    <name>A0A9Q0RE45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE45"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="364"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="537" mass="64119" checksum="6CAE72743CE64B5D" modified="2023-09-13" version="1">MDNNNNNQIQNANQNQNENEMKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNKFLREESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLKSNEIEMKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNKRLKGKKYKHKMNEKKRLFHSFFSLFDKDSISKQDFDKLKQFQIFLPNSFLVDIQNKVIQDNQKEIEEKWKKEVEDKNKEIEDKWKKEVEKNQKEIENKDKENQQMKIEIEEKWKKEVEDLKSKFELMELKNNFPQFSDSEIIKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHNAVDRKGKTLVIIKTKQNFIFGGFTQVGFNGNSGWIKDSSAFIFSLRNDKGDRIPAKFTYNGNGLAIYSHLNYGPVFGNNDFRLDSNLQPGWSNFGYSYNLPNGITYGTDEAKSYLAGSYKSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFL0</accession>
    <name>A0A9Q0RFL0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFL0"/>
    <dbReference type="OrthoDB" id="2400221at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="296" mass="35640" checksum="D73984872E545C3D" modified="2023-09-13" version="1">MSFPIVDYLIKTIPEIYDFENIYKDLNQKIFNEECFNQIERKFEMRLERLYKDLKPFKIEVSNFVYSDSDLEFRREIEEDFKFKEQGLNLRECNQMLDEIDKKSQTQNCKFLLDQIYKLLQKKYSEMLTNEYLETTIYNFAKEKVKNDLIDGIVDASPNFKTIPKLKNVPFLQKEIQERLIDPFENIPTIFKKKLLKMDGILSEAFSKINSSKLFNLFKVIIEHLKDKNQNQNQNQNNIPEFGNLKEYLIDFAIDKDQNQNQLAQQIRDYFPSNLQMENFIEVFKLLNNFIRSRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFL6</accession>
    <name>A0A9Q0RFL6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFL6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="534" mass="60623" checksum="9F2DE63B955C67CE" modified="2023-09-13" version="1">MTEFHQKLKDKYIRKQILKQKQEEKQQFEEIIAKVIEGNQHGIDKKFFETLDQYKLEQKIFELTEKLKELKTKKHDLFELMRAILSSEPSETNLENTEKKSTTQKDMKEKLPEIYGQITPTQGHQTGLLFHTTALVQLQQQAPVGYHTVLTETGKGGIIQQHPTTVEYKESGGIIEDPARGIYIQTNSGGIDSKVMGRPQAQDRYQHYSVKAYPKITKKPKYPSPNFTKAPSHPLQNSLRRYPSPRESSRYLSTSNSPPPTGQTIKYSTQSIGINPHPSKVYLSPHEQSQNIQNTSIENSNTNTPPNLTTNPPKNSINFESRKSRFVLDRLQSVSQRSPISGRAPPRYTTNDHGADMVSSPNAKPPTLVETGHLRANTNPNANSHKPPIIPPTSLATQMRPPQKPYSISHHILPPRSSNDPDSPYDPQQHGQGFPYQSNSPLDRSSYSSPKQTGDTPNFKTSSLHDHPQEFSQKDDFRKTFYSPNPQMHPSRNPHDPPNSLNNSSQMSSKFSSREKKRQQSIYLDHPDIKRANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFQ2</accession>
    <name>A0A9Q0RFQ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase -related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFQ2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="149" mass="16864" checksum="3220A7D189AE2EA8" modified="2023-09-13" version="1">MDTSFKTLVGKSNAQFLGVCALFLIIGIVLGGIGYSGAVYELGYIGTGIFALSIIFVLVILSVFCTRTYQCFWIKTIWFILSTNSKSKKDSNSKSISISTNSKSNSNSKPIQNQIPNQNQNQNQNQNQFQNQFKQFQQFQQFQQFQQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG30</accession>
    <name>A0A9Q0RG30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG30"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="298"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="486" mass="57401" checksum="64BCC9630A682414" modified="2023-09-13" version="1">MESYSNLEKLSNDLKNLFPNEEESYFDFEIICEQNKISFKTHKAILSARSQYFKSLFKSKMKEYQENKLILKDFSSSIISSILNYFYSGKIEINLENAIEILIFSSKYLIDELIEFSSNFIKKHFQFETVVDVLKLSESMNFNQLIDPSYQFILENFDEFMKTSFFLELEENHLNFILSKDTIPTEEFENFQSIIKWGKHKSNISQEKENQKLEKEEKDKLKNGISDLIYKIRFIDFSQDEIGNVLKEDLVGNQVSQKLVQFQKMQKNKKDLNQLIEKENQNPHSFIFKSRFKFKSLIIKEMEYYNKIREWINDDEFLSKMKLGFSAKRDGFSDVTFYEKCDNKGKTLVIIKTKTDFIFGGFTSVGFTTDILKWKESFGSWGNISDPEAFIFSLRNDKNDRKPEKFPVQKDKSHKAISYYPGYGPRFGDGNSDIAVFSDFQRENYSNFGDCYTLPDGVVRGSKDSYKYLAGTWYNWEIEELECFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG32</accession>
    <name>A0A9Q0RG32_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nnp-1 protein putative nuclear protein 1 nop52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG32"/>
    <dbReference type="OrthoDB" id="17995at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="907"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="927" mass="107268" checksum="422481AA7666C0C2" modified="2023-09-13" version="1">MQQETDYFANEMVESFEYDDEDDDFCENENDESDEDYDDDYDEKFKNYSQNLYSGPLDIPLNVIKMLTEKPKKKAKIGTKIKLTTRNLVKIFSQMKNSNPKLQSIIYNAKYNGRAFKKHSLFNSTIFISVLKVPINGLVTIPLFNQNIAISKSKIIQIKNEKTDTNTNTNIEEKKEIVLSFGVQNNNYCFITNETGNYTIEVEFLVPYLTERGKELNLQIPVSIQNELIYSVPGDQKVKIFCSEAIDNANQKWEEITQIENIENQQPEGQIPGKGVTTFQSTFLSRSNISISWTEPQKIDLFDSEPESESEQESDLEIDDKEKKEDKQEAKKNKKEVIINVEQHILHSIGEGVVLTNAQFNFEINNGTKSFFEIAVPTVRSTPKFKILSVKGHSIKKWKVVSKEENEKDNENENEKDDESDESDESDENNEKNNENNENNNENNNENNNENNNDNENNNESDDEIDQEMKETTSSMQTIQKKQILKIWLEYGVESNYNLLLETELEMKSTSCYVSLPVFECLGKINRETGFVAIEARTNVEINECESKNLAKISTQEVSDEIYDVSKGSLLYAYKFLIPSFDIILKVTKHKDASVLISIIEVAHITILYSKNGEILHNCKLKVRNTQKQFLRVYMQEKDKSSHDPKSSNCELWSTLVDGKSVKPAIDKDSSILVPLNKSDSSNPDQPPFIVEFVFIQHNQAPLKEKGKLSVSIASFDLPINYLCVTLYVPKNMKFSEFDGDLKEVYAFSKEPNLITQRLYGKRNEISPTLKIYQEEKMKEKIQDKKKKKKKTKSKTKDIPKKKPMMKKISMKEQIFLDESEIQDDFESEDFFNEEKGGKLGISTGKSFQQQEKAAGVLAVHIEDIQTQRSFLFERLFLTKKPLKLTADFQEIHKKFYEKRTTLDTKYLTKVFLFILFFVFTLWFKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG59</accession>
    <name>A0A9Q0RG59_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dd-gdca protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GLACQNG"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052326">
        <property type="entry name" value="Diff-Dev_Assoc_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33459">
        <property type="entry name" value="DD-GDCA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33459:SF7">
        <property type="entry name" value="DD-GDCA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040205504" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="317"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="607"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="898"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="1478"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1593"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1650"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1593"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1677" mass="179690" checksum="38564F46B95CF88E" modified="2023-09-13" version="1">MKGLLSLSIILFVISVVLTTQFFTDSIQKELNQVEDGCTPVTLGGLGDFCNETNYQGCYDELWCNSTNVCAEKNDGASCVSDSDCSGGLCQNQTCTGKVVAGRPCQYDTQCYTGNCTGNFCVGIAENQACTLDKPYTCDVGLFCDANTSTCIPQIQPGQQFQLKFAGPGELCDEFQNIYCYDALWCNETSHTCAYDNTGTSCTVDDDCAYEVCANGTCSGPKDAGDNCVVDKECMSGNCTGGVCVGLPSGATCNATGEDGQCGVAKSSWSHFSGELDFILICTPGYICEPTNYSHIEGYCTQLYSQMSGQSCVINEVCEFGLACQNGTCVEHTEYCDMDHMSCPVSSYCSCSDNYINGTCKSVVNRHCEPEIHDLVNCMANNSCPFGEFEFVPGTCAYEKCLAEYNIAECCLQYGHQDTFYLPNGMTCPNVTCPVQVTFAGPGELCDYDDNIICYEHLWCNSSHLCAYDNTGSSCTVDTDCALRVCANGTCSGKKDAGDNCVVNNECMTENCTGGVCVGLPSGATCDVNGHDQQCDVGLFCDKITNTCIPSIQPGQECWSHVAGEIDFILICTPGYICEPTNYSYSEGYCTALYSQMEGLACIIDEVCEFGLACQNGTCVEHPEYCDMNTMLCPVGSYCNCSDNYINGTCVQLANRHCEPEIHDLMNCMANNNCPFGEVEFIPGTCGYEYCHDESVIVECCLQHDHNTTYYLPNGVTCPNLTCPIQITLVGPGDICDHDNNIMCYEHLWCNETSHTCVYDNTGDNCTVDTDCAYRVCANGTCSGPKDAGDNCTIDNECMTRNCTGGVCVGLPSGAVCNLTGHHQQCGAGLFCDANTSTCIPSIQPGLECLSHISGELDFILACTPGYICEPTDYTFTDGYCTKLFSAQHDSQCVIEQVCEYGLACQNGICVFETPSCDMANMSCADNAYCNCSDNYMNGTCVEVANRFCGPELTDLMNCLINNSCPLGFAEFIPGACAYDKCYDQSVAAECCAQYDHSDTYFLSNGITCIKATCPVQLTFAGPGAHCDLTQDIFCYENLWCNSSNLCDYDNTGESCTVDDDCALRVCANGTCSGKKDAGDNCTVDNGCVSGNCTGGVCVGLPSGAHCSLNGKDGQCGAGLFCDANTSTCIPSIQPGLECWSHIAGELDFILACTPGYVCEPTNYTYSEGYCTALYSQMSGQACVIEQVCEFGLACQNGTCVEHTEYCDMNTMLCPVSSYCNCSDNYVNGTCVHLTNRHCEPEIHDLLSCMNANNCPLGYGEFVPGACAYDKCYDQSVTAECCLQYDHSDTYFTSHGITCHNATCPVRLTFSGPGDICDYDNDIVCYEHLWCNSSHTCVYDNTGESCTVDDDCAYRVCANGTCSGPKDAGDNCTVSQECMTENCTGGVCVGLPSGATCNVTGHHQQCDAELFCDKITNTCIPAIQPGLECMSHIADRLDFMLACTPGYVCEPTDYTFTDGNCTELFSATAGQSCVIEQICAFGLACQNGTCVNQTTYCDMETMACPDNAYCNCSDNYINGTCVEVANINCASEMNALMTCLMNNKCPIGFAELVPGACQYDKCFAETQTAECCLQTNYTSTYYLSKSIVCGSPSPSPSPSPSPSPSIAPTPTTAASSSSKSKLGLGLGLGLGLPLGLAAIGGVLFIVLKKRKKKTSSTDTDALIGDDDDDGNPDYKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGS9</accession>
    <name>A0A9Q0RGS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGS9"/>
    <dbReference type="OrthoDB" id="411646at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="295"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="497" mass="58389" checksum="5EE9283E5CD676F7" modified="2023-09-13" version="1">MEEISKNPFFIDLKKKFSTLYEKASGNQWLVCVPSKSSFTKSQINQEFAEMHVLKPSISFKDVFDTNTNPPKSIQIDGTTIKTREGFSKKRNISIITKEIFFNENFQPFNAVLIETPLVEPVEKEVKEKPQKELRQKPVVEKQRQQTQTNQKKKPKEKIQIVPEPEFNIYNTQEVISLSGEIITVSSIFPPHKTLEEISKFLTKFHENFQVFPKIKEKLKEFKQSYFFVKKYEEDAANRIEKLCEDTFSIFINVNPKFSVLANQKYNKIELLSIMKMYVLGTLNIYKKMRELYSEEDDNCYQQIKKEYQKNLLILISNLQLKFFQNIFQRKTPFEMMLVLDATIQKLTKLAYPGKESKSKLLSTDDLLPLLIYTITLSQPTQLYSRMIYCSSFNLTNISTSKFGFIDASFQTSVLTIHEGNACSKYEIEQRERREVERKEQIRLKQEKKKEEEKKERLSQIKRTNQSPRVIDLNKKQGEVKVGGFLSNLLSRDDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGU5</accession>
    <name>A0A9Q0RGU5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_14599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000037">
        <property type="protein sequence ID" value="KAJ5079123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1319"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1390"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1416"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1449"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1501"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1542"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1574"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1605"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1639"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1715"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1747"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1786"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1817"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1879"/>
            <end position="1899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1905"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="304"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="835"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="966"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="432"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="579"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5079123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2024" mass="236176" checksum="1EC00F185D82E183" modified="2023-09-13" version="1">MLRNIKSKNQKKKKKKKKKKKKKKKKNEKEKSSQSEDKSDKEDLNQIDSETESEIDSETESESISKTISETESEIDSETESETENANENDQKRKIQIPNQNQNQKINIQNQVDMILRNQTKMENQILNFIENQSKNQLLTQTTQQKAKKTTTKTEKQIQNLVQNLIQNQSHIQNLLNNLIQIQFQNQNQIIQIQNQNKIMEMQKQIQMEIYNQNGIQNQNQNQNLNLNQNQNQNQNQNQNQNQIENKIQFEIKKNSFQEIYFEEKSKKIQISKLYQFIPQEYNIFLICELISNFKTMLQNEENCDFVIYVGNNNEKIFCNKSILNARSRFFYEENHQNPNKDELYLQKFEFEIVKPIISFCYDSEFKFDLNKFEKYFQVAKYFKLTSLKIKIEKEITQTINEKNVIMIYFKSILIKSHFLSNICEIFIQKNIDKIIEENQIEENQIEENQIQENKIEENQIQENKIEENQIQENKIEENQIGEINDTQIKKIIQIIQSTPKENKIDLIWKLAHQWKQKFEKKNKNLINKYQYIDPIQIQEIQDNIEDFYYIIDNIKNDKYNINDPKIQNNPILPSNHQLELINQKNQQLNQENQQLDQENQQLNQENQKLNQENQKIKTSHQENNQKIQKIEKQLQQFQQTNQKQNEEINQKKLLIEKQKQKKKQLKQELAENVSEKAKYILQKSQNQIPNLNEKSIEEIIKFMKQCPKYQDIQENGSLILKEFIQTYQNNRDIIIKLNGIETIIKAMINFPNNQNIQYNGFQIFNHIVFDTQIYRLKMKQNEKMGIILQMIQNFLKDEFILENSLLILQRLSSGLEKNQTENRKKNGIEIFQLNGIQPIIQSMRNWVNHESIQEKAISILINIALLLENQNEIRKLNGIETIIKSMNNFPNNRDIQEKGCEALLNISINNQENQNEIKKLNGIETIIKSMNNFPNNRDIQEKGCEALLNISINNQENQNEIRKLKGIETIIKAMNNFPNNRDIQEKGCGALRNIIINNQENQNEIKKLKGIETIIKAMNNFPNNQIIQYQGCGTLLNISINNKKNQNEIRKLKGIETIIKAMNNFPNNQIIQYQGCGTLRNIAINNEKNQKEIKKLKGIETIIKAMNNFPKNKNIQYKGCGTLLNISINNEENQKEIRKLKGIETIIKAMNNFPKNKNIQYKGCETLLNISINNEENQKEIRKLKGIETIITAMNNFPNKLVIQYQGCTLLVNFLIKKENQKEIRELKGIETIITAMINFPNNQVIQYQGFEALLNISNNNKKNQKEIRELKGIEAIITAMINFSNNQVIQEKGFEALWILSNNNKANKLFQTFDIPISLFVFLNLLIFKIYHFVFNLFLNSNKNEEMNNNNNNNSNNSIAIISRTNEREGEKESNLNIYYSNDRKMNIYVNTETGILLYLQYLFFFSSIKYTNIMITILSMFIGVGVSNAFKLIFNTNISTRRSSTMKFVGSLFIISSFFVIFILLNSTQFAQKINNPILHHHQLLHYLGNTIESTTKMMNILFFSVPIGVASPLILYLSSLTSMMIDLNSSKFVPKSSSISTVLLISLTVSFPFAIWQVFFCGSFDFLRSFLFWILLVFYIIISVLVRFLGFMNTIYISNKFAGLTFYLMYIITFVSVLISRFFDVSVNDISLKSTFFLFFLVLVGMILIDFSNINTRPTSSVYTTVEYLNQEEMVQSHGNEVKFIIFNKDKMTATLHSLFKEIFNSKESRSLFLFFSINFIFMFFEFAYGIMTNSLGLISDAFHMLFDCTSLIIGLVASIISRWESNDKFPFGYQRTQIISGFSNSCLLIFISVFVFFEAIERTLNPPVIYTDHLILISVLGFFVNILGIILFSDTSTTAITESGLENSSLSLDEENLNSLGNGVPKKNPNLQGVFFHIIADTLGSVAVIISSLLVHFYNWVIMDSICSMILSCTIFLSVFGLFKNTLRTLLDQTPDISTFINQVIPKIESIPQVESVKNFHFNHVSESLLSASLSVVTVFQDRIPNSHLILQQIKQILFDSQIVHPNNVSIQLETQKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RJ25</accession>
    <name>A0A9Q0RJ25_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_03869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RJ25"/>
    <dbReference type="OMA" id="RLQCFLG"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5080384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="155" mass="17438" checksum="B60316C4EAF6FF0D" modified="2023-09-13" version="1">MQSIKDKFNAIKEGVSSENNSLGTTDRLKGFVLLFILGIVSIAISFIRLTPVAFSPRKFALMYTLGNLIIIGSIGFLVGFKKQFSSMFEESRRLASILYLFLTFLTFYVATKSQKTIIVIPLLIMQIFSLFWYSLSYIPFGRTVVSSCLNICSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6Z8</accession>
    <name>A0A9Q0L6Z8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chascon isoform d-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6Z8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="461" mass="54511" checksum="C7BCF1C46F1CA9F6" modified="2023-09-13" version="1">MSEENLPFYAQIILDNKKDSDYYRITIESIQLTFFNLRTKKEEKFKIQTDSTAYLNQKEPNQILLYIGGTIRFQLKFDSPTFASNFGQLISQKKAELQRLKQEQQQPTLEYIGTRIRKSFDCVLTTPFGLQISKVKLIIKRKGLMLVEGEFVHFQNKFSQNDEDIEILENKQSPLHWTIHLKNQGLFCLKVETEEIATEMKNAFIKYLKKFKQSLKEEEPILEEDLSDSKEQEVSDHYSSEKEEKNQNNENQQVNNEVEDFQEIFQPTKNIQLNSNEFHIYIISTKQLGTISVKPKSLLVTLPKGNAPFIYEKDMQISISKANNSLLISIQSKNIHLVFRSKEERQNFIDLFLENKHKYFRENVQKQDKKKSDDEDSTEKEYKSKSDDDDDEKEKEKKSKSDDEKEKEKQSDDEKEKEKKSDDDEKEKKSDDEKEKEKKSDDEKEKKSDDEKEKEKDDENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L789</accession>
    <name>A0A9Q0L789_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rcc1-like g exchanging factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L789"/>
    <dbReference type="OrthoDB" id="70707at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="219"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="297"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="414" mass="47590" checksum="182122B72E1490EF" modified="2023-09-13" version="1">MNEILFFGLNKNPKLFKNKPKKITKPIRFKFENENENENENENENENENENENENENEKQIKQISSVHDSTIFLFENGKAIEYLSENDSNQNPEKIQIENIQKVTVGWKNEAILTKEGNVFAKGRYINRKNPKEFINISSLIEDTNDRIIQDIVSGSHSFYLLTSNQNAYGIGSNNYGQIGFDSVTLNETEKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGCGYSQDGQLGLGESRKKWKIEKLTKIQNIPKGKIIDIQYTYEFTEIKSSLFENDNNILDFSCGNAHTLILTSNSNLIGFGDNSYGQLGTGNTKSQLIPIQIELPKLRFNENISNYHISCGGNKSFLYYYSPSFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7N0</accession>
    <name>A0A9Q0L7N0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7N0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="40020" checksum="BBBAD292A61C6B2E" modified="2023-09-13" version="1">MNDCLFFGSNQFPKLIKNEPNEITKPIQFKFENENENENENEKQIKQISSGYYSTIFLFKNGKAIEYLFNSKQNPEKIQIEENIQKVTVGYDNEAILTIERNVFAKGYYVNSKNPNKFINISSLIEDKNDRIIQDVVSGYDSIYLLTSNQNAYGIGYNFDGQLGFDSKTLPKTEKPILMMKNVSKIFSGNTSYSVFLLNSNQELFGCGWNNYGQVGLGESIKEKKIQKLTKIQNIPKGKIIDIQCGYDYSIMLIENENENENPKRKLYSCGYWQYNGLGKNEDTYEFTEIKSSLFENDDNILDFSVGNVHTLILTSNSKLIGFGHNFSGQLATGDTNDQKFQFKLNFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L856</accession>
    <name>A0A9Q0L856_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor i-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L856"/>
    <dbReference type="OMA" id="CISICEH"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF366">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="261"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="419"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="657" mass="76860" checksum="650A7F3E10C13BC7" modified="2023-09-13" version="1">MATPQKYKLPPLPSTLPKPPPLPSTLPKPPRLQKSQSTQIPTQTQNINQNQNQITNSIEKPIEKPKKETELPKKKEIDFEKHPRKILYQDPSIDRSKWHLKLIEKHPEIQDLRERLIPIERTQSFGEIYNFGTHDVKENLSDDMILQVIMQHLGCLGYKKTRSILEEESKIKYQENHFKESRLRGLLRISLKEIEKIYDIVMESSDSKEEDPRNELLEQLIKLGYEDEDENEIVNDVFIWDEPPDSESNIIYADESDKSLGEKEIKAATLNKLIEKLTHDGSGIKIDSFLMTFQSFTTKEKLLQKLIHRYHVPKSKELSEEEYQKKKKSIQLKVINVLLKWVDNYFSEFSKQLIQQFQEFIENTLIEDNKTLADKLKNAIYKKQKGLDAKKTVFESPNIPDPIVPKNIFSPNLSIFHVHEEEIARQMTLIEFKLYSKIQPTELLNQAWSKAKYKHRAPNVLSFIQRFNDTSGWVATTITKSDRLQHRVHTIEKFIKIAEHLRALNNFNGLTSVLAGLNNAAVYRLKHSWSSIKLNYQQTLESLKNQMDSSGAYKTYRELLKNVNPPCIPYLGIYLTDLTFIEDGVPDFIGNLINYTKRSQISKVILNIQQYQQKSYEFQYVHQISQLLLKIRNLDDSELYNKSLEIEPRNRDISEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L868</accession>
    <name>A0A9Q0L868_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Macroglobulin / complement</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="QSARIDM"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02891">
        <property type="entry name" value="A2M_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="4">
        <location>
            <begin position="361"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="5">
        <location>
            <begin position="735"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="567"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1446" mass="164807" checksum="7BF9C7BE8AD8080D" modified="2023-09-13" version="1">MGSNQTKKKPTNQKKEEEQKDNKQDIIANLQNKGNFWNIGKEMEYYFKTSRFITLISTDKITYKPGEKIYIRIIALDAFTHRPFNITENFYGEAKCEIMDPMNVNVFKSDIEISEQSTFSLSWDIPKNIKGGEFTIKFSMMEFAGFPPTLRKFTIRSYSPPRLKSELEFIQKAYGEGDEVQANLSVQRAEGGIPEGATVTAIARLDNQEIYRGNYSIDKNGKCLVSFKLPNQISVGIGSLNCSIKDGGVTESASKSLPIVLRKLDVKIYPEGGELIAGVRCGVYFEAITPNGKPGDFEGILICDKDKDQNQEKGIIIKTSHEGRGRFEFIPQFNTQYSIKINKPFGVTVPVMLPKALKTGVSLISNKTVFNYKEPITISIASPQEIKELAVVLFKKEQEICHKKIQKLEKEQIVELDHKIFDGVLRVTVYDIKNKKPLAERIVFALPEDEIVFNIIPDKQTYCPGDSVNLTIESQTKSGKPVEAFCGITVTDDAIYQMTEKRERPPRLPAMYFLENEVEHLEDCQIYLSPQIQIQNQNQDQKENEKENQNQYQNLDLLLGTQVSLDDDYETDDDYDDDDDYDDESESDGEDEDEDEDEDEIIESRFKRREDIKFKKNDSIKAKSKPQPKKEKQINENENENENENENESENENEKQNENEMEIEEEKEREEMPIAKPIMQKEMQSKFSKEIMMKPAFMEDLKEIKPTRITRPYLREYAHTGKPKTSNQRQDFTSTLYYCGCLKTEKRKDKILRKISFQLNDSVSSFKVFIDGFTNEGILGYSESFVLNSQKPFYLEPRLPLEVSFGDQITVPVALVNSLSQNINLLLEANVLDKGLSLKGDSKVKEVLKPNERTKKHFQMIVNNAREDSRVKIQGVDESNQQIKDDVTRTISIKPAGFPTKLQMSGVLNPDEKKNYNFDIYKNILQGSLRTYCAIYPSPMSNLADALKSLIREPYGCFEQTSTTVYPLIMAQQYFKSHSGVDPNFIIESNKKLENGYKRLIGYECKEGGFSWFGSSPASEALTAMGILEFTDLSYVFPVDRVMLERTKSWLFSKLDTEKGIFIRNSYAPDHLSHAPDEITNAYIAWSLSESNIEIKQFKSAIDYLIKNTKEGGFANDSYFLALVSLILFNFGMKDDAFQLAKKLLDLEAQEADGVVKKSKTSITSSSGRNLWMETTSFAVLSWLNFGDSFMENIIKGIQYINSNCRGGSFGSTQATILALRAIIKYDIINATIRKEGSVELKLNGNSIDALGFNANHHEPLVFPDFANEIKIGEENNFELEMVEGSALSFALEIQYTTLEPNSDEECQIDLSTRIIKANSNDQKENKIKQGELTEIEVIVSNKKNIVAPMTIAIIGLPGGFEPRYDQLKELKNKNVFAFFELFGARELVFYWYNLKPNEKISFNIDVLAAVPGIYQGPPSRAYLYYSNDLRVWNEPLKIEILSDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8W1</accession>
    <name>A0A9Q0L8W1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8W1"/>
    <dbReference type="OMA" id="CKETNGA"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="191" mass="21263" checksum="CCEB0F837E2342B3" modified="2023-09-13" version="1">MNTLKIVVVGGGGVGKSALTIQFVHSKFIETYEPTIEDSYRRQVEIDTEVLLLEILDTAGQEEYAIIRDTHLRSGDGFMLVFSLTSKVSFQEISLLRDQIIKSKDSENLPILIVGNKSDLAKERKVDSKEAQALAKTYNCQYIETSAKTRTNVDEAFFALAKLIRKKAGYSTSDVSKGPKPPKKKKSCQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L945</accession>
    <name>A0A9Q0L945_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L945"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="143" mass="17342" checksum="68A854F002BD5099" modified="2023-09-13" version="1">MIYSNRIINPKLYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDELETGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L946</accession>
    <name>A0A9Q0L946_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 2-alpha kinase eif2-alpha kinase -related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="710"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="615"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="487"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1575" mass="182406" checksum="83CE3245F2B48DF0" modified="2023-09-13" version="1">MEIHIIDILKTIYDEDLIERHNTNDQQNRVFSVILKPSKTDRLVSVMIDIDWKLGISIFSLGKTQGLSQSEIKHLRQIIQSKNNIPDGDIFWNLQYIKEYLSDLCSQDISITSSPISSTDELVITTQNDIFENSFLQYNKKPNNQSQIEPTQNNNLSKNLPEDNLRSFRDKFRETAYQKINSQTKPKKSPPKKLNRKPSLTPNSILGLPFDSDESTSQNTSSRSYSNSNLSVPDKPLLLSLSPQEQTPRKFPIHEKQQALLNQLLKFACSAIHSSTNLFPFVKKSLIDLNLLADSKEISDQELESHFQQLVQNFPQENSLLSQFFHNIKESALYKKSRYQTDFTDIQILGKGGSGTVVRAKNVLDEKIYAIKIIPFPSNLNVQNKILSEVASISELHHKNIVRYHNAWIGGLEAAIGESDEEFQSRQSDSNQDLKSKKNQYQKTSESIEILSTSTPTQKSIENLDKRNSAHSANPSRVRFLDEEMNKNQNNKNKNQNNKNKNQNNKNKNQNNKNKNQKNKNQNKNQNNKNNQNNKNQNNKTKNQNKKKNQNNNNFEFPEDIFFKPINKNQNNKNQNNKNKNQNKNNNKNQNNNNFEFPEDIFFKPINKNKNQKIKNQKNKNQKNQNQKNQNSDTDSDTSSDLPFDFDAINIDFDESFNFTISDPKSTEDLENYIIFDYSKSKQKENQNNQNQNNKNNQIKKNQSDSEQNSPAISFEELSPLNSLYKTRQNEDITTNSRRIITPDSVFENIQPQWMDNDDFDFKSRSDSEEEQNIGEIRSLDDFQNFFENSNSEISENEDETKNKTYLFIQMEYCVMTLKKLLKERCLNEERLWVIFREILEGLKHIHTNKIVHRDLKPDNIFFDTNDVVKIGDFGLAKKYDEQAKNINSQNTPIGKGQPSGTYLYIPPEHFTSSRPIDETFDLFSLGIIFFEMWQPFSTQMERVKMIQMLRNEHKLPPEFEFHFPIQAQIVKNLTDPDPTKRHSAKYLLEESELLRRFLHEDSILPAINLIADRNIIEKEHLKKLIKAVFHLQNRLDFQDQKSNKGDNELTNGNSLEKSPVDDILPDFENSTFLHSLDPLDILQLQSRLKSRLSKIGELFCAIRIDLPLFESMKEIPVRYDNSTEMMDNVGNISLLRENLLVPYVRFVVENRIRNIRSYTHGSVIRANGRRAEEFRFDVIQCSGKEPVFFDLDPLFVLDTTVHSLDNVVTENHDKFSPRSPYQQLSISSLLQKIQEHRLGLPGYTIKISHTEMLKSIMHICGVLDHTPQSLAHICSVLSPRRSNENQSLNLSQKQLFFLSQFRGLHGTLQNVILFYEKNLQKQLTSELKGISDLKFLSKALQSTSISSRIRFEISLFDPQMSFYRGFFYHAICAIPRENFITRILTPKKPSRKSRKFHYDSNSVDSVVIASGGRYDSLLSWNVQYSQQGVAQDPTASGFALSLNNFISSALLPFQIAFQQFQYRSSSFSSIVSPSPDLIIVLFSNDFLQKASLLLSLLRASEIKALMKMSNKNRIVDLIENAKILNVRIVIIYEKSGSIKLKDLLYSNDNEYSDQDTQDILNKIKYLLRKKKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9F8</accession>
    <name>A0A9Q0L9F8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9F8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="483" mass="56757" checksum="623334EE7348CBE7" modified="2023-09-13" version="1">MEHFTQFYQEKSSNEIEKNKNINEIPNNQTNEKETFIENNKQNKTTENPNLNTNLNANFNSNSNTNFNSNFNSKPNSNFKSNYNSNFNPNYNSNFNSNYSPNFNSNYNSNYNRNLTSNFNSNFNPNFNPNFNSKKFSNEEDSIDLKQDFEHKYDMKQNYGIKDPSNVNIFENRYEIPDLANQNGFDTRTEKSNIQNMLFSGGNPVDSRFDNSFIPSNFDNSISEKRYSNPLANQSISNESLVRRFFSNTNDEYKSNQEKEFLDAINYFNGENTNEDENLNENLNENQNLNQNEFNIPKKSLNLEKELESETETESDNEIENENDNENDNDLENENENENENDNENDNFNFGENKLQEKNEFENEEQQKANQPNHLEALSSDEQIIQEFLMQPLNPKEKINRKNPSFGVIIYLYIKNNIRTHCKKSTLPAKYQMMKKANSTSLRKGRCTPELAKWIIRSGYLNKVAQMKKQKRNKRKIENTNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA29</accession>
    <name>A0A9Q0LA29_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA29"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="89" mass="10308" checksum="E21FDBA4B526E71D" modified="2023-09-13" version="1">MTVQEIFMIILISDSESTCNISLLGRQFIALEILFSNSYSVFFLMSCCFDCFGSKLQVLVLAKRGANWQLLLFLLLQPIFHMMINREFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAN0</accession>
    <name>A0A9Q0LAN0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division cycle 14 isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_12303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAN0"/>
    <dbReference type="OrthoDB" id="266663at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="282"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="371"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="718" mass="84177" checksum="54F872DE1FABA7B2" modified="2023-09-13" version="1">MNSRLKVVEFIKNKLYFCPTNKKIKPEKMKHHYFTIDPIFEYLSFFEDFGPFHLGYLAVFCHITLKKINNPNLKKKIIFYCKNTEEQKANCSFLISAFMLICQNKSPQEAYKPLKPLEPLKPFRDASPEPSNYPLTVLDFLEGLDLAIKNKFFDFDTFNIDDYLFYEQVENGDFNWIIPNKLLAFCSPRDDDVDMDNVYKDFYHLTDEENLNEDLKENSNENSNEDLKEDLKENSNEDLNENSNQNPNEDLNENSNQNLNENSNQNLKENSNQNPNENQTEEERLQNDNKLLMEFGWSPERYIPLFQKLGVTSVVRLNVPLYDKQKFINASFQHFDLYYQDGGLPDWDIIHNFLHICEQEYEEDEIRNEKENSIQNSKENPKENSNQNSKNQKKRIIAVHCKAGLGRTGTLIGAHLIKNYGFSAKQAISYIRLCRPGSVIGCQQHFLSAIEQDLKKEHEKEKKKSEEKKRKHINKKKERISMLHPLTPQPRKVAQVLSSKKEPPKTQKSNFSQARISHRKSLKKLDNQNQNLDLGTVRKNLTNIFNLEKEKKKKKQNDKMNILDEKSKSKSKSKSKSIQKNSKSKKRIKIDSSEDSEQNEEQIKIKRPKSKSKSKSKSKSKTNQNNNSNLKKQNSPQKKPKIIKKSSKLTNNPSPKKKPIKNAKKPIKVVEFELANKKKPKEKEKEKEKEKEIPIKKKKKKKKISVYSPRKYFLRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB27</accession>
    <name>A0A9Q0LB27_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB27"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF0">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="6">
        <location>
            <begin position="331"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="583" mass="69138" checksum="CBBAEF31809E7644" modified="2023-09-13" version="1">MNNKNKKEFKLLEKQKITPRNQTLDRFLMPVNRNQNQNQNYNQNQNQNQNQNTQFLNLNQNQNQNQNQNHNQNTQILNLNLNHNTQFLNQNHNQNQNYNQNTQILNLNLNHNHNHKHKHNKRKHQYQQIQISPKKSKNTTFINLPWNKKNKIEINNKKIPKWTFMKECWKEVKTPKDFMLSILNFHPEYKEKWNLFGLHQFFKRYQKKQENEIFMKETFTKIVSLAQKKVIKEPIKLMKQNQESSFTLTQEQVACLMANAFLCTFKPRKWAHPNDPNALASINFIDLYNESQNTFLVAQKIKALIHYLLRVNEHKNYSNIVFTKKVLHQFPKWEDSDFPILFVRISLDKNIEDFPKENHAHVDFANKFIGGGVLNHGIVQEEILFITQPELIISRLFIPELLPNEALIIQGTEKFSTYSGYGNTFKSILNFKDQTEIDKKTNIRKNTIIAIDALKFGYNQSQFEKNQILRELNKAFCGFNFQIEGVETIVTGHWGCGVFGGNKDLKAILQLMAASQAQKKIIYCTFNDVHFSQRFQKVLDLIYQKNLKVGDLWKLLVLYHESKFESKIQFFDFLLEINQIDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBA6</accession>
    <name>A0A9Q0LBA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBA6"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="486"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="764"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="869" mass="100992" checksum="FCFC54ED4C262B6A" modified="2023-09-13" version="1">MEMEISENINNNNNNNNTENTNENINENTNQDIKAKSYVGPIMYPRVEVKEIVECFKKSFLLNLSVQYFIPSHWVSFHNSKVLKRIIWGDQEYSPNSDIVCLILHSNSFVPKNILDSKQNLLVTLNFKNKNQNSPFLSKRRNGICSRETLRAQNGIAVVVEKCETTLEVPKTLFSIEEIQIQFYEDVLQIENVKKARIDQKDFRIKKKPITQLFNETELENDEEFDDIFSQESIIFSLSNDPCRSYSLEAIRDSGFQPDSWTSYRFQREVLYLESPLERYEISLNQEGLFRFAIVLEPEIYDISRLLSEKIVPMKNDQINIVEDGLKWSDFRWSESSILIPIQYLKENSKQNLKENSNQNPQKIKIPNIKKVCICSQRIEAVLTFEGNIFAKGKDINSNNPNEFINICELIENTNDRIIEDIVCGYGSIYLLTSKRNVYGIGSNHFGQLGFDSPNKADTPVLMMRSVSKIFSGNCSLSVFVLNSNQELFACGNNSCDQLGLGELKTKSQIQKLTQIGNIPKGKIIDIQCGYMHSIMLIEDEDGKRKLYSCGDYNYNGIGKKDRQNTKKFTEIKSSLFENDNILDFSVGDKHTLILTLNEKLIGFGNNFSGELGIENSLIQSTPIQIELPKLSFNDDISNYHVYCGFSNSFLYYSFFSNLEDDLIKLFRRKEFCDISFKTINGEVIQAHKLILNFRIGTEQNQMEKLQKIISKKTMKEANEIFEIIYSSKTNFFSSLKTEIQREFDMYENITETMKRIYYSEETKDFIIKRNEKLIKFPKLILIMRSELYRGMFLSVTEDKSNQVNDYSELSDEAFEIFEYWIYSNQIKEGIKITKELINEIEQGIDYFQLNESNPNLFDLLIKQFNNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBD8</accession>
    <name>A0A9Q0LBD8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBD8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040236892" evidence="2">
        <location>
            <begin position="25"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="622" mass="70753" checksum="C0571E322CC8D6F2" modified="2023-09-13" version="1">MANNFKFNLFQFIFLIFLIEIRLSQVNKQFEFKFNEGKGDIAASLPDQTFFFSGVSGNWLYPSLFSSGVNMTQTNVLQSNFIYCNCSDLTQGCGLNSTSYTEQASFEFWFLQPPANQSIYTLFQILSGDWFFVATTDTSQSPPQIQIAIFDQNQNPKVLYSNISSFGFLNHIVFTYKKNGNFSTYYNGTLINSIIHSDGNNYLTMTQNEAELTTVAIFTRFMYLGVYGSELSSSYILSRFNNGPPPAPPSILINSLNIQTNKTFQLKDIISLESFTNETNDTFILKTINIFDLNYGSIYTFFDGIKTNLIYNEQELNVNLSSQFLFEGNLYQDSYITKWNISLFDKTNNFSTFPNPPYSIQFNVSINPPNPYCSSLSTYCINIDKSCQISLIGNDQYSNLDNAIINSIPLNGSIYQILSNQTKGSKIISNDTIVDYRSFDNWSVIYEYEENLNHSSQQLINFSYFVTNNRGKNSTNCNENIIIQNFLQVNNQKVNLETGKIEGIELECESILKQYNFTVIIENILEANGANFYSDSEGYITIKTGSTLPQNSKMIYILGGKETIITINYSIYEEINSTIYYSTTATLNISIPNSPFSNSPSFLFNSLSISISIFFFSFLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBI1</accession>
    <name>A0A9Q0LBI1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peflin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBI1"/>
    <dbReference type="OMA" id="CVIMQDA"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="267" mass="32085" checksum="97DEAF39951CF2F0" modified="2023-09-13" version="1">MYPFQQRMFQKTTPNTTTNTTTNTTQTRMVQQFNQPQYQQYQYQQQQFSPQQQNQYGYQHQNYNQQQYQQYFQYQQQQQQQQQQQQQVYFQQQQQQMQLNMQLMTWFQQVDVDKSGTIEAEELKKALELSSEKFTYETCSKLIKLFDFQKKGGINFQEFKQLFQFLRMMRTAFEKIDLDGNGTLEMDELIPALQHAGYNNLSKETVEVLMGKFGKNGKHVAYDAFISLCILLQQSKNIFIWFDQDHDGKVTLDLSLFTYMMSFMKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBL6</accession>
    <name>A0A9Q0LBL6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cathepsin l1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBL6"/>
    <dbReference type="OrthoDB" id="3789175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040144525" evidence="2">
        <location>
            <begin position="18"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="4">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="124"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="459" mass="51583" checksum="DA4610AF899A7DB6" modified="2023-09-13" version="1">MRIYLLSFLLIFSFVFSKKISFKQGLTNSLKEEKPTPHPFEVYTQNFNKIYEPEEYETRKEIYMKNRKKIKAHNLYFLNTWKAGENQFTDWTDEEFNAYLTKFPTPESEFTPLDRSKLQPLTDIPTSFDCSGNMTSAKNQGSCGASWAFSAIGITEGAFAIHEDILIDLSQQDAISCDGSDSGCYSGTTYGGLGYLSVSGACADHLWPYEESNGTCGGTQKTDCESQKYVYLNQINSTDLTSLPENERVDVLMQIVSTYGPVGGFIDASLLDTYSWGLWNIPWCSSNTSDANQFVTIVGYGIEGTTPFWKIKNSWGTDWGEAGYFRFVKGLNVCGIENYAFFAESVMNFGLTKFNGAVTGLKVVSNSSKSFEISWDPYPGADKYFVKASLYNGEYLYVWETSNTSFSKSIKFRYITATCWVGPIKDSQYGNLGVSITFDSAHTISLSFFALLLILFNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCP7</accession>
    <name>A0A9Q0LCP7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCP7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="210" mass="24782" checksum="681E7B8C46809882" modified="2023-09-13" version="1">MSFLIVGSLFLTKNLQNTTIEEVLKQEEQKKQRKEILAKERKERIQWEKELEAKKQKMGFWKRKKETQLDKYYQSVQEQKEKHKMHVENVNAEVEDSSDSIDSDINIDSDDDFDSSDDNPNDESKKKELRKKKTQALFDQLEPNSSQNLQETKNVEKKNPKKNSQSESSIDSDNLDDFDVSSLDESTDSDLEEKKKKERKENTQKLFQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD78</accession>
    <name>A0A9Q0LD78_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Import inner membrane translocase subunit tim16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_11881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD78"/>
    <dbReference type="OMA" id="CSTFING"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5069125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="130" mass="14467" checksum="674F41D31CEC14AA" modified="2023-09-13" version="1">MTALTDLVKIGARTTSNFFEVLLKSYKEAACANAPSGGVLQRFLGATLGLKAQNPLSVQEAFSILGLSQKETSEEKILQRAKELFKINNPRNGGSPYLQSKILTAQQVLMKNKHENENENEKEKEKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDB7</accession>
    <name>A0A9Q0LDB7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDB7"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053086">
        <property type="entry name" value="RhoGEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45834:SF3">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45834">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="225"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="446"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="709" mass="83874" checksum="DD21CB62A28241A0" modified="2023-09-13" version="1">MISKLSKREEAVLELIETEFSYVRNLEVVVNIFLEPIVKQGILSKPDIAMIFSNIETIYWINKLICQEIDAKISQTENYNINEIRIGKLFKSLSGQFNIYRHYCRDHSDANQTFKKVLNQSNFAKFHKQASEKKECSKKILPDFLIEPVQRLMKYPLLLQEIIKYTDNDHPDYQDLQDAKKSIQDIIEFINEDKREMENQEKLILLQNSIEGLPSNIILTNNKRKLILEGAVAKISHGRSQERYFFLFDDILIYSKILSLKKSKYQYKDSIPLSVILINEIQDSPKKDTSFQLIRSDKKTKYILNFKSKYERDQWFKEIEKYSTQKIAESSENSLVKNPRRTLAKSFRNTSMIDLLSTNVTQNQLSFDEVQKQLLEKFNSLPNEVNESNIQIVDDQNYKGFENEMEIIKPREDVIEKANLQTLINIEKQIQFNSKNKFQLSSSERKFIVEGELKKISESGKKSSIHLWLFNDGIIIASKMRFKTKYQFKNFIPISSITQTRILSNTEILQNSFSILQKNSKKKLIFRCESDEDKVMWVNLIRKQMKLNSIEKENQEKEKEENNQENNQENNQENRENLSTISTFTETSENDEIEIPEINQEQEIENENEIEIENENENEIGIENEIGIENEIIDEKPPPLPPKINTMFTKEILLTKNQNELIQIFLSIQKKYQNFKQKKINLKKLFEEKQNEFYIFLDKLTQDIHQEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDJ4</accession>
    <name>A0A9Q0LDJ4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_11427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELAPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039181">
        <property type="entry name" value="Elapor1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727:SF15">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727">
        <property type="entry name" value="PROTEIN CBG13728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040444301" description="MRH domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1500"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="551"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="1297"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1557"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1568"/>
            <end position="1582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5069915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1609" mass="181036" checksum="A50B4CB0AE427A62" modified="2023-09-13" version="1">MKVLILLNFFLFLNLINSKTFPKICDEGQYLNQENNSCVNCANGTYSLGGGILYNNWTSLPENFQITCTGNNCISWITEGSYIKSGNSGTDSTDSILKYWVYLNKDGKIEFSYKVNSQENKDGFIFYIDGFPRINLESSILEYQTVSFFLSSGIHQFEWVYHKDSSISTGLDCAQIEYIKVIGINYSANQCELCSKGYSSFSTSSECFICERNYYSPKEGSEQCLQCNSTEYSDIGADHCIQRENCTDDDYQFYFSDCENNKRTKKWRLIEPSICSNVSDKPDEPGYSCADCNPGSVMNNSVCEFCQEGFQRNQSSSVCSPCEEGHKASIAKYITNFIDLPNEMYTDCYGECGYPGWRPMVDYLDSGVGHLGFIQNSIVQFINLSNPGNIIFNYTLQCENVTTYQVYCGFNFFIDNVVYYSMYDKNITNQVVEYNLTSGEHTVGWIFWKAYPNRSYSNNDFARINQIIIHGVSPQEGGADTCQICPEGTYSEGNSSFCSLCKPGQYGNQTGLSKCYDCQENTFSKDSGSTSCLDCGPGTTSQSGASECNTHNCTFTINELNITYNLQPLESNNSMNGPVFDSYGNKYYLSICNQNPTNNTCLDENNQPILTYACQESSSNISIDIGNIIGFETLSSNPRDGLIVSFGNGEIGCDSNQHRNSSITFNCDIVSGIGHPIPDGNVIDPQNPCNFKFIWNTQYACPLCTERDYSFFYTDCINAQRQKIYYWIENPKKCFGGVSLPANEIVSCTDDIVCGAGQYSNGTDCVDCSQGSYSLGGGVIYNLSNFNQIFQMGCVSFDNIVNQNCSNWTVIGNQTLFAGFGKESWFSLITNFEVDGKISFVFESFAILPNQKLVFSIDNEAFFTYEGLLEFSQHSQPISNGPHIFKWNFTNENDFDNSSLYSIIIQQISAQGIAKSADACTVCPPGSYSNQTGSSKCELCPINTKQPQNNSIDCIPCDENYYSLSGQTECIPKNPQCFEGIDYYPVYSPCKSNSQSKNYKWYLAYPTCIGNLPEPEIVECHCNPGEYSNSSTDYNCTTCPKGSYSLDQDAQKCIQANLGQAAILSLNLSNFIDQFLIEEHKTFCSGDCQLSTGWRIGDNYLDSGIAGNQEVNSEFIFPNVSIIEDGIISFDYKLVMNQSQKNKNYNYNNKENGFNAILEFIINGEPVIGALDNATENYQHASFPLSKGIYELRWVYHQQCCIQGQAYLLNIFINGTSVGKSQQLINCDNGYFSNETDSINCSLCEPGSFTNSSINGYSSCFLCENGTFSDQYGMQFCLDCGNGTYSNKVNGSTECLTDCIFSFDNNIQFNLTTLNNKGINSIINPNNVTEKFYYSVCDKISNTDFCKDSNGNALDTYICEIGKNYDINFGKVLSISEITALINNENYTGIRINYTYGDVINQEYAQTQVDFICDLSFGIGVPVVIEKHLNNQDPNAIKYLEWRSQYGCRICLSSDYDRIEGDCNKGTKKITYIPNKDDCVSINPPPSETENCSVMEISPFLLILFPILFVFVITFLLIFWCQKRKIYHKYTQLKNQRVGEIEFDLADDFLQDKTQSLTQTENEHENENQNENENENENENENEQIQKRDEMILESEDIRKNWVLSQLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDT0</accession>
    <name>A0A9Q0LDT0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDT0"/>
    <dbReference type="OrthoDB" id="17015at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="656"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="761" mass="89628" checksum="1F2FE942C8C10690" modified="2023-09-13" version="1">MRKFEETFNNPKKILLLVCILLIQMLIFFRCLDKYNNFMNQGIPPTNQNINNLCACLKRILPTYEDHSIIFTVSVSGLKWSHAIFSCWWTGMPPTNYFATTINGDNLFQAINRASKSCSNQNQNQNQIQNQNQNQLENKNQNQNQNPNFKLKFVGTEWPLLTVLGGKEKINHLFDEIEIIKDQDCYPYIYPEIQDPIILNQKLKDVRSKNQSLIMYSSIFDHEAHDTETERLNFLDNSIVELFKKDTLINFIKENPDYLLILSSDHGDSLSQFHGESQTLPTKNIGFFLFYHPDFQYQKWIQIKDVDITATLTSFLKSVDIPFFSFGKIGNSYISRNLEDEYKIELMRNIIQLKNVANYYEKEIEPNFYYPHQNQNEFDQFLQSSSVETLSRIASLYRAILSSPFKQNYLFDMIFLIILCVSISLILLILNYENLIIETFTLIWTFWPLLTVWWQFKEYFINQKLFFPLSNLLLSLILIKIEPTYKFPILKIELLSAIILFINIFDPFSPSIYQKIGLIIISFIIYLFRNEPEHQMEIIQKSQTKLKQNKETIIVLILHIFIILFFITQDINWFYFLFDFHIFAFGFYSIIFGIMITSFIKKDTKIGVEALCWMIFILQNYYILYSDLFLGKQALDWNVDVTPGEVGITSWNLYPIFSAFLMFIGKTGTLIIPIIYSIIFLKNYIFSLLLLLLEVSISSLALIWGISIFNDEGTGPIVELFDLMIIYSIILIILILFHFFQEFRNFTQRNQNRNEIIEGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE52</accession>
    <name>A0A9Q0LE52_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exportin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE52"/>
    <dbReference type="OMA" id="AENEFLM"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exportin-2 central" evidence="2">
        <location>
            <begin position="112"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-2 C-terminal" evidence="1">
        <location>
            <begin position="484"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="936" mass="109129" checksum="3B23304D50414654" modified="2023-09-13" version="1">MNFDEETINNLTTLFQNTLSTNKEIRKQDRWDEDNEEIGLTSEEKEKVKENIVTLILTTPKLIQRQLSDSLSVIAFFDFPDRWKNLVPELLQKLATKDFSTINGILSILIPIIKHFRYEEPSDELFLEIKYVLENLQQPLLDLAQEISNHFDTTDNNDIGYVNMMLSSLIKISKIFYSLCVQVLPEFFEDNMKPWMEIFHKFLNYENSSIISQTDDPTNIEKLQTNIIQNINLYVTKYTTEFDEFIKNFLTDTWTLLLKTTQDMRYDRLVSTGITFLTSVAKGLQKNLFEDNEVLKNICEKIVIPNMYFRDTEEELFEFHPVEYIRRDIEGSNEDTRRRSACELVKALRSNPNIETLVTEIFSEYVQIMFNEYAENAEQNWKSKDAAISLVISLATIASTQSSGVTKINELININDFYRSHILSELNTEDINQFPVLQADSLKFVLSFRNQLPKEELIGIFNYLIRLLTSQIYVLNTYSSIVIEKLLISRDLQTRLSRFTHDDIKPFIESLLENLFSILTFPDEKVNDYVMKAILRVIVVAKSYILPYAEVALKQLCSILLDICKNPTNPMFNHYLFESIAALIRNCKSENQDLQSFDEVLFPAFDEVLQQEGTDLSPYVFQIISQMLELSGQNISNSFFSVFLTILSSPLWESRGNVPALSRFIQSFLSKASQVILEKQQLEAVLGIFQKLIASRANEVEAFNILNSIIKNIDLSHILPFLERIIRIILLRLEKNKTEKFKRLLAIFTFLFISRNDVLTFVKQVEMLQEGLFQRLLDAYILPVVSKIYNHKEQRISIIGLTKLLTESKLILEKNFSPFWTRILLSILELINNYEKTTEKQADKMSKLNDDKQVEELDFNTKVEFSTRFSLLIFSTTKIHDNFVLPNPKEFFINQLKIFVNQNSSVNFHNFIQQSEPDLYQQIIEFLDSLGFAFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEC5</accession>
    <name>A0A9Q0LEC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEC5"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="172" mass="20270" checksum="E8A176DD64CBB0A8" modified="2023-09-13" version="1">MQNVFDENYNPTIDDLHRKQIMKGEQQALLEIRDTAGQEEFRNTLDRHLRETKGIIIVFSIDSKKSLQRAKKLWNLSSETKETKKFPVIFVGNKSDLEELRAVTEEDEKQLNEEFGVPVIESSAKTGKNIKRLFDQIINLIDQIDEEKKEEKKEEKTEEKEEKEKKKKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEQ0</accession>
    <name>A0A9Q0LEQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEQ0"/>
    <dbReference type="OMA" id="SEETHKW"/>
    <dbReference type="OrthoDB" id="45963at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028260">
        <property type="entry name" value="FAM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206:SF1">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14774">
        <property type="entry name" value="FAM177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="362" mass="43507" checksum="43CFD396BAF504C3" modified="2023-09-13" version="1">MNDFDSDEDEKDNPKNQTKENNEDIWDYLSWGFSKVLNGIDFVGEKIANFLGLTDSKYQHWVDLYFDELEKQREERAEEQKSYLDNIDHLESKGFFDNDNDDEINSIQIDNLSLSQKSQKPIDNDIFSIEKPEIIIENQNENENENQNENENENENENQNENQNENENENQNENENQNENENENQNENQIENENENENENENENQNENENENENENQNENQNENENENQNENQNEIENENQNENQNQIENENQIENENQNQNENQNQNENENENENENENQNENENQNENENQNENENENENENENENENENQIENQIENENQNENENENENENEIENENENENENENQNEIENENQNENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEQ6</accession>
    <name>A0A9Q0LEQ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hyccin related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEQ6"/>
    <dbReference type="OrthoDB" id="18937at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF1">
        <property type="entry name" value="GH21176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="505" mass="58166" checksum="20AFE03592C1B765" modified="2023-09-13" version="1">MTNIHEAVQNSDSKLVLQLLDKGEDINKKTEQLTPLHLACSLGNTKMAKLLIEHGAEVNSKNNRTPLHYACQANAVASLIQLLLDSGADINSRDDDTPLHFACFNKLNEESMKALLSCKPSLNITNNYTPLDCAIKKIAQKEVIEMLKLAGAKTKNVANSDFQSLFNEITQAMKKKQLLVTYIDTINNFKEQIVDSLVENEGFTNNLVHHSLLRKSYEDCQAICHWFYDWYQSGTSKLQIFTIKYFPILVWKFLYFYTHSSIPQAKQKQQITEGDLQKLASIQAFLLSVFYSEIESKEKRVFHPVSLEIPSVFHKPFAQKVQKLTESSLQKHDFQEQQRKLVYIENIPMIKSFSTLNSALFAKVLLSKFNQYHSEMPINSLQNYCAICARIATIGSEKAFDIDQETVTKQIHQISQEKWVEYMLYYPEYHEKEKKIKIENEIKFYLSNELFQEMLSGIMLCFSRSQDLINSAKLSLSLIHYRAVYDLIPEVLLTTNSMMKISENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEZ8</accession>
    <name>A0A9Q0LEZ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEZ8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="25011" checksum="0505569D1986A10A" modified="2023-09-13" version="1">MQFSHNFFKEEKFVYIGDAIKETQGLIIRIFIFHEYSPIPKSFELRIKSILPRFKRICYGQNVHNYDYSYDKIRKLIDLSYCSTETFITPNIDIIEVKQNKDITLYSLYSRYKKQVFSTRDIIQKDEIIQLKTTDKLDLNSINECYLFSGKRFDSFDIESGLHTIYIYRVFSNKEMKSRYTQYFVFEQFSYYPEYEIKYRLHNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEZ9</accession>
    <name>A0A9Q0LEZ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Suppressor of swi4 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEZ9"/>
    <dbReference type="OMA" id="KDYTVMT"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="25"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="395" mass="46176" checksum="D56345AD5DAC441B" modified="2023-09-13" version="1">MGRIKRTKRKQKRKKRKELEDDENPFSLIFNKGSVGKKIKELIANMRKVMNPYTSTNLRIKNSNTMQDILQVCGPLSVSHLMIFTSKKFSAYIRITRFPRGPTMTFKLREFSNSRDVIKLHPNPPSPNKEFAKSPLVVLSGFAESSVVPLDNEQDTLRKKRALKLTSTMLQNMFPPIKISEINLPDCKRVALFHYIPEEDTIDFRHYLVRMRPIGITNGIESLLHKKIPDLSKIEDISEYILDSVKDNTENLQNEKSNEKSNDAIVNIQSNTNSSQNRQKAIRLIEIGPRMKFELIKVEEGLLTGEVLYHKYIHKSPDQINLLKEKHLAKQRFKQQNQNQNQNQNQNENQNENEKEKEVQNENQQNLEQNPKRLKNLKKKHSKKRNDLKNSRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF19</accession>
    <name>A0A9Q0LF19_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF19"/>
    <dbReference type="OMA" id="MSENEWR"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10688" checksum="194FF83960568638" modified="2023-09-13" version="1">MADDIYYSPKYYDDEFEYRHVILPKTMGRKIPSDHLLSETEWRAIGICMSRGWIHYHYHKPEPNILLFRRPLTEDQKHLQKQLGTQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF52</accession>
    <name>A0A9Q0LF52_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear transcription factor y subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF52"/>
    <dbReference type="OMA" id="GDDHTDY"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="92" mass="10952" checksum="E66A589363F579BB" modified="2023-09-13" version="1">MRRNANLFKLTHFEQIRFISNEVPHVISKATEFFITELTRRAWFESQIFQRKTIKPEDIATGATKSEIFDFLIDFLPEDLNVDFEKDDINLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFB0</accession>
    <name>A0A9Q0LFB0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine-protein kinase ulk3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_09997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFB0"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="81"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5071837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="626" mass="70367" checksum="A51FBE597B71DE8D" modified="2023-09-13" version="1">METVKCAICFERFDSKRKPIIICSNGHSICEKCVENVKTCPFCRLRLDKSKFITNISLLQIAEEIGERISDVPVIPLEEIIIDPNPFQTGASADIFKAKWGNQNIVVKKLRVGGDENAEKQLKDEINLSIGLSHPNIIQIYGIVKFENTSGIIMEFAEQGSLLESIPNLTKHESITIGLGIINGLKFLHRKKIAHRDLKPANILLTKGNPKITDFGISRVLQTVNRNTTVAGTIAYTAPELLDEGTIYGSSCDVYSLSIIFYQLFSKQEPYKGISVGRLVLKIMKGERPDIEKDFPNDMNELKELIKKGWDHEQENRPNLDEFEKCFKKMEIESGMKDLTLHSKMNMKPNYEQSPPKSPKITTTTEISNQVKSKIVPVKTIGIKWKDDTDTEETKKLRFNMIGDLKSKSNFRNIFNSSILQAIEVVPRHLFTFSQRRKGWNQTSQLQSSEILLAYTYSRAMKASTQSNTSSPEIVGAQLSLVHLSPGFSVLFVGAKGGYIQSIAAQIVGLNGKIVVYSSQNEALEKAQGICQHNTPLSNIMDWIYNESIEDVQPIKDKGPFDAILFGGYVTEINQDYKNLLSDNGTLLAPLQVDGSQRLTTVYRESGSSFRVNIIKDWRVRFGKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFQ0</accession>
    <name>A0A9Q0LFQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFQ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="222" mass="26076" checksum="EA7027905D49490E" modified="2023-09-13" version="1">MKKKNSNSNSNEEKSNLNSNEEKSNLNLNQEKLNQEKLNQEKLKSNENLNSNENLNSNPKANLPLIFYPSFNAFNGKVSAQISVSKNLFFDSPFSIHKEKILISINKPNSQNLNQFASHFQSFNFRCIIFDNYFRRGTIISFTDGNHTIKANNKRKIYKEKCNQREKNYYKKDKELMIQRLLDQGIRIKSKELIIICTVFLSSKMKRKYPAQLIHEEKTKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG30</accession>
    <name>A0A9Q0LG30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG30"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="126" mass="15321" checksum="1D543BB5FC8AC2E6" modified="2023-09-13" version="1">MKQTKNKKKQKDEQTKEIKDKQSKEIKDEQSKEIKDEQPKEIKDEQTKETEIKSKETEIKSKETKDEQPKETKDEQTKETEIKSKETEIKSKETKDEQTKETKDEQTKRNRNKIKRNRNKIKRNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG46</accession>
    <name>A0A9Q0LG46_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG46"/>
    <dbReference type="OMA" id="RSCFNTD"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054472">
        <property type="entry name" value="WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22977">
        <property type="entry name" value="WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="593"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="845"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1072" mass="123066" checksum="DC449067C9EF631C" modified="2023-09-13" version="1">MEFITELTKECENAKYLINDFIQKILTLDISIPFESDVEYLELMEAHYMMSSLTLDGNNNISDVLGVPQPKDKPLNFEETQKMVISIQKVKTKIEEIKEAKLKTMARKPRIIRWAQKLKTTEKESLALHYILLLHVGSKIRGLKIRESQDPVSLALHAKMTITELLEFVKPQRLYIKQGIFEYFDTTHALQNNMSLKQEIILALVGQDLTGEQSLKIDNTALSEVLDEEKDPEELKKKKELEKKIREEEKLKKEQEMNKNVPDFEDESDLYNFISQQVIAEKTKPDEIEDELEQQLKIEMENQLENQLENELENELENELENQLENQLENQLEKEDDLDKDKEDKDKDEDEDQMKPYKTDLEYLEDHFSRFTMLIRVSNEKQNEAQSRYYGGSSQSEAVIREYSAKERVARMKCEKRLELTKEAGDWLPRMERLAEARKLNEFEKYVVLFLIGSNISQDMQNAGAARGSNVESILRIFCENLQDQISKRKYFYKSGALIRDGIIRASGSGLDNNLNDLYLMVDRRMLDFVMGLDTEMSELIEGSHLYTSKVKLESVILPEEQKKLITETMKNYESFTKCRKKLGLDEVISYGGGIVMLFYGASGTGKTMMANALGNELGRKIMLVNFPSLGQMSAGENMKYIFREAKIHQAILFFDECEALFESREHGKYDVNLLLTEIERFDGIIILATNRSFDLDEGMHRRITVAVEFAKPDPLLRERIWMTHLPQTLKSSEDVDIKALAMKYELTGGFIKNAVLSALSVAVSRDGPDNVVLTQSDLEQGAKLQLRGRLRMTEFHRRVVPQRGLDNLVLPKETVETLIEIINSEKARQVLYNWGFDKKIGFERGTTVLFTGPPGTGKTLAAEAIGFEIGKPLKVINAAEVLSKWVGDTPKNIDSLFEEATMHDSLLVFDEAEGLFGRRHETQDTSTDRYANIDVGLLLYHMEKFNGVVILCTNVIGAIDPAFFRRMKYIVEFKIPEIQLREALWKKLIPDSAPKADDIDFSKLAKLYEFAGGNIKNSVFRAASRAALRPQDKRLITMDDLINAANEENIKVKRSRGELLDNEKEKNSIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG82</accession>
    <name>A0A9Q0LG82_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tripartite motif-containing protein 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG82"/>
    <dbReference type="OMA" id="YSEEWIQ"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="758"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="814"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="939"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="758"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1050" mass="124939" checksum="54235DBD8C6DE981" modified="2023-09-13" version="1">MDEDEKLNNFFTCPICYNIFKDPRILNCGHTFCFDCLERMFKESQGKIKCPLCRKKTFLQSINNLPKNFTINDFLENFLEKKQKEKEKQKEDEEFFKNLARNRNIYRNRNQNLNQNQNLNQNQNRNQNLNQNLNQNLNQNRNQNRNQNQNLNQNRNQNLNQNRNQNQNQNQNLNQNQNLNQNQNQNQNRNQIQNLIQQEIRNQNLVENLFQIYEGNFVDENELYSEEWIQFNQNREQRELDLFNIIQNFQNQNQNQNQSESQSESQNESQSENEDENEDEDLIFFEEQNRNRNRNSNRNRNRNQISNDSNSLISENEDEDEDENENDLLSFHSISSISENENESQNESENESQNESQNESQNESQNESQNESENESENESQNESDIEIQIQNEDEIQIQNLDENYEVIFQNENEDENYSGNENDLLSFHSISSISENENENESENESESQNENESENESENENESQNESQNENENENQNENESENESQNENENENESQNENENESENENESENEDENENQNESENESQSENESQSENESEIDLINLEDENQNQNINQNQNQNQNQNQNQNQNINQNQNQNINQNQNQNQNQNQNQNIIENQNINQIQIQNEIDLINLEDENVEEQIQNFGYFPINENENQINELLQSDSISSLNGIKSQSYSESESENESENENESQNESQNQNENENQNEIDLINFENQNESENENESQNESQNESQNENENEIDLINFENQNINQNQNLNQDENQIQNQNQNQIQNQNQTEDENQIQNQNQNENENENENQNENENQSQSDFETESESDLMNFENGNEIEIENENENEIQSQSDFETESESDLMNFENENQNQDEDENQIENEIEIQNQIQTQIEKQIESDLIDLENFAEFISLNKTQNEMNNQLDFQSNDNQSELFQKFLDDFKYSKDRVLKLIDINGFNNPLDNINDLKNKNQNISQNINQNQIQNQIQNQNQNINQIKNQNQNQNENQNQNINQNINQIQNINQIENQNQIQIENQNQIENQNQIQIENQNQNINQNINQNINQIQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGH1</accession>
    <name>A0A9Q0LGH1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activating transcription factor-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGH1"/>
    <dbReference type="OrthoDB" id="551672at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="204" mass="24298" checksum="BC41AB4E8F6DA30F" modified="2023-09-13" version="1">MFCLNNFSVNPLDLFDNDQQNLLYDFDIPEENNTEENQNETLMSTFSISTNKDQQEIESQETEKETEEAKEGQKEKKTRRNSNLQQKVMIGNKEYDLGGYLTRDQLKKLTEEQKRARRMIKNRKSARKCREKIKRKLDDLEIESQEIKRLNVDLTKQLEDLRKERDSLKSEITHLKTKLVEAANQKERTSNPVFSNQNQLRYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGX8</accession>
    <name>A0A9Q0LGX8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGX8"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="128"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="574"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="617"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="363"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="725" mass="85600" checksum="4D89EEDFFA9355F6" modified="2023-09-13" version="1">MDNSSNKTKLKKNPKSLKMQIQDMFQNQNKNLLQIRNQIQNQIQIQIEDLFEKQNQMFFQNQIQIQNQNQNQNQNFNLNQIQKIYFDKKPRKIEISKLYQFPLQELNKFLIYELLSNYKTMFQNEENCDFIIYAGEINQKIPCHKNILNSRSRFFYEKNHEKADMDELYLPKFEYDVVEPIISFFYGSEFKFNSNNFEKYFEVAKFFKLSSLRIKIEKEVSQKINAKNAIVIYLKSILIESNYLSSICEKFIKENIDQIILNDEIGEINNKELRNIIEFIQSTPKENKIDLIWKLSRDWKEKFKKTNKNLINKEEYIDPIQIQQIPEDINDFYYIVDSIKNAQLITSNSKTENNPFLPSTDQLRLMFQKNQKLQEENQKIKEENEKLKEENEKIKEENQKIKEENEKIQKTQTEQTEIIKQKNQEINQLMESIQEKDQEINQIKRPIQQKEKNKIKQIQSELDSNVTEKAKQTFLKFTTRISELKKDSIKEIIDTMEEFSFSQDIQEFGCYLLQMISAENERNPVEIQKLKGLQTLIKTMNNFPNNQLVQYHGCGAVGNICADFKNKNIIRKLNGIQPVIDAINNFPNDSDVQYHACGALWNFANNEPNRIEIRKLNGIQPIINAMNRFPDNEGIQLHGCGGLKNLAANEENRIEIPKLNGIEAIINAVNKFPNNPQIQMQGSSALWNLASQNKENQKRIIKLNGISLLKQSMNIFPNIQNFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH63</accession>
    <name>A0A9Q0LH63_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Motile sperm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH63"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039283">
        <property type="entry name" value="MOSPD1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34441:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34441">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="7">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="190" mass="22125" checksum="43797A27FEC2E7D9" modified="2023-09-13" version="1">MNLADFVINPKQISFKSSEERPTRIIRIFNKNKSRVRYQIKSNSPKHYSVKHTSGDIEPDSMTTIPITLKEPITTDCKHLFKIEIFEPNNEKAIFSKKIPSQLLVDSQSESPEPNDTQNDDEKIPDSPPKTYPFNSYLKSVKGFFRKYAIFILIFFLIKLIAKDKRAWVTFFIGAIFGYFYNFIKGILDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHI4</accession>
    <name>A0A9Q0LHI4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">tRNA (adenine(58)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_01580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 8"/>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHI4"/>
    <dbReference type="OMA" id="RPDHRMI"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="10">
        <location>
            <begin position="65"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5072565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="307" mass="34814" checksum="5E482FC5D8F8505A" modified="2023-09-13" version="1">MLSENEVCKEGDHVMIYAGRQILFSVVLEKGGQITKKFGTIKHKDIIGKKFGTRLGFVNPNYPDIYVLKPSPHLWTFCLDHFTQIIHYTDIAVIAFQLELRSGSIVLESGTGSASLTTSLAKFVAPLGHVHTFDIDSSRVENAKISLEKNGFGNIVSVLERNVVEQGFPFEKEFADSVVLDLPSPFLVIEEVARVLKKSGTICSFSPCIEQVQQTCSKLEENAFTGIETFECLLREHKVCVFGGFVDDEEKEKKQTEDQMEVFEYKRRKRKKMKEEKKEENIKLFTRAIPEARGHTGYLTFAKKNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHU5</accession>
    <name>A0A9Q0LHU5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHU5"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="92" mass="11367" checksum="93FA982953B91913" modified="2023-09-13" version="1">MKRIYLNENEKDFIIERKEKQYKFPKLILIMRSKLYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIKITQEIINEIRNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI95</accession>
    <name>A0A9Q0LI95_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_09350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI95"/>
    <dbReference type="OMA" id="KAAGYMT"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5072904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="516" mass="57116" checksum="D87931DFE41D190F" modified="2023-09-13" version="1">MEKIEFQQKNKILLKLIITTILLILFIGSVSSIPFLFKQENKITTSIGIIEEPKNVTKSNNVILIIPDGFGVASQTLAREYEGVDFLTLDQIQKGTCHTNSASSPITDSAAAGTALACGLKTYNGRIAIDTNGNPCVTLIEKAMDNSMATGIVVKSRITHATPASFSSHQLDRNQELDIAVQQLNSAFGKIDILFGGGRDMFIPTSLGGKRTDGRNLETEAESKGYTVIHTTNELNQTNLQTPILGLFTSDNYPYVIDRQNLTDFPTLQQTSQKALELLSQKAQEEDINGFFLLIECSLIDYCGHQNDPAAQVRETLQCNQVVKQMMDFIDSDSNENNTLLVVVADHETGGLYLDTSLEEIYKSQLTYVWNPDILKPITKSAYSMTDLVYYNGYSVEDVLSDFAQISNLTQSELDELNAALNSHSFDQLNYALSDVISQRAQVGWTTHGHTGVDVIVYSYGNDSNSFVGSMDNTDIPKKIDQFLQFESLESQKILENSEISFYSSDSPKINDSFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIF3</accession>
    <name>A0A9Q0LIF3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIF3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="407" mass="48003" checksum="3A8BFFDA4DC6CAD6" modified="2023-09-13" version="1">MINPLCQKDHIILHPELLFAEELEPRGYQEQVHLFYRDLETPQIRTIAHEKDPNETAFQMKQNLDSCQIQNGQTSCHQYFENFGCQNKKEMRSCQRYLQNDSYEKRNEKTRSSRWMSVEKNDREEDGDGEKFEDYEIGEMEYDEMNEFSLLNQLNQLNQLNQFDELNQFSEFNQLNQINQINQFNQFNELNELNQINQFDELNQINQINQNNLNNPNNPNNPNNPNKSNNPNKSNNQKKLTVNPSLPSKPSRKKRKNKKQKSNKSKTNPNQNPNSNDLQELEEFLRKPVTKIGERLDKLAKHHPSLFNGWESKTYKMFVKKGIVPDHVEIHNDVIKILLQIQGKKGEKKSKAPRGNSKIVKTKHWRNTRRGIVGFFSRTMKMINITSHQHGKITFEKPKNPQPSINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIN3</accession>
    <name>A0A9Q0LIN3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammecr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIN3"/>
    <dbReference type="OMA" id="THCHNRR"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="199" mass="23387" checksum="273786FFF85C0874" modified="2023-09-13" version="1">MSSIEATLEMTYICFETLLEIFDYKYEPTKLTEKESKSKLPLFVSFHKIKENKNTLRGCIGTFEKQKLEEGLKKYTKKAAFHDSRFKPLKKSELKNLECSVSLLTNFENAKNYLDWELGKHGIRIEFLNYHATYLPHVAPNRSWDKITTIQHLARKAGFKKDLNDNILNQIKLEKFQASKISSLFLDFLKAKKMDNFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ31</accession>
    <name>A0A9Q0LJ31_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related c3 botulinum toxin substrate 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ31"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="349"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="585" mass="70129" checksum="19D8E5EFC689C0CC" modified="2023-09-13" version="1">MQKENQKKKEKIKRKSKRNAKKKKSKRNQKENQKENQKKIKKKKSKEIKNEKNQKENQKENQKENQKENQKEIQKENQREIQKENQREIQKVKCVVVGNGGIGKTAMLLSYTKGVYLGEYISTIFDNYSANVKVNGEPINLDLWDTAGDEDYDRMRHLSYLDSDIFLICFSLISPSSFESVKDKWIHEIHYYCENAPIILVGLKLDSRDDQETINELEERGLSPITYQQGSKMAEEINAVKYIECSYVTQQNLKTVFDEAVKTVLYRRKIFKKEKKLKRKQEKLERDEEFKKRKQEKLQRDKELRKKSRKELKKKQKMRLEKKNGIKSPIPKENYKIYPELKKISRKKREQLQIPKEKFERKKEEIKEEQKKEIKEEQKEEQKEELKQELKQELKQELKQELKEEKKKTIKMKFGLIGDENSKKNELIFGLFDKKIPKDFIPKPFRIYRKKMVFDGKEFVIRIKDTSEKGKFDKEKISWYSDADFFFVCFSLISPSSFETVKSKFIPQIKQNFPNIPIILVGTELDKRNNLITEELKQEILNVITYEEGFGFAKENQSIKFYLECRLKSRKCFETILKRIFKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK24</accession>
    <name>A0A9Q0LK24_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-related protein rab-5c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK24"/>
    <dbReference type="OMA" id="VDMESDR"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="208" mass="23377" checksum="83F82495F8B972E5" modified="2023-09-13" version="1">MINPTTSSASKLVVLGYASVGKSSLVLRFCKGLFYEYQEPTVGAAFLTQTITFGTTETKLEIWDTAGQERYQSLAPMYYRGAAAALIVFDITNYESFIKAKNWVKEVKQQSQSNEILVLVGNKVDMESDRKVDYSEAENYAIELNLAYFETSAKSGYNVKEVFIEVAKMLPQTPIDQKLPEIVTKPTDQFKVTDEDPSQIKKKKKACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKC6</accession>
    <name>A0A9Q0LKC6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKC6"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35397:SF1">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35397">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="689" mass="81958" checksum="57A630ED4FB525A2" modified="2023-09-13" version="1">MQNQIFLTEPQKKILKNLSELFKLMQKLENVFNIKSSIREKAENLLECLPFLQLHSFHYKKISKKRAMIQIFLRIWSHLLNDVGAAIFDKRHLFYKSISAIARREEFSILSNQPENDRILSQYRSLMIETQTLVDSKLITEKGKGFSLIFPFCVDMLAVNFFRLPGVSHALVSHFWDNYQRKKVKHNLHFRRIFQIFSSFEKSLQSLNFQENKQIPINSQEIFSNQGYFYQFNTELEKSLAQPFVFPKKLEKSLSIANDLKKTKNSTDLFQVRTMQAGKLNLFKKKNNNKWASTTFQANPTSIVSQIAVFERWENEGPVWIDRMEHMNFLIMFIGSIFRFVEPIYGKNLSYWKFPGFIEIIKALIFEICKIKPEDITKELTIKLIDELSNIQIINIIFQVYLKRTNAYNAHCVDCTLSNCETIIKRVYLKSCQNSNLKFINSSTLKFLNLNLLLESIRTLLETDNYQNLMTTLAFIYNIIDFLPDNFRNQLISDFILSEKFFFKFFLSSFEVVRDYFCYIVVFKVQRTKIRTGFALEPEKQTQDQKLFTQIELRFRSIEERTGYDLMKFSNFSQKYEPVLEKNEWIEIFKDFVDFTYFPKSLEVYLLLALKSLEKVKAEVKLPKELIYYPTNYIHLEKATIDRIPKFEKSKNNQQNNKNNQQKKKHLKKKILQKNQNQNQNQNENENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKN8</accession>
    <name>A0A9Q0LKN8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKN8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="162"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="280"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="567" mass="66795" checksum="BB25EC57F5BD7404" modified="2023-09-13" version="1">MNDCLFFGLNQNPILFKNKPEEITKPIQFKFENENENENENEKQIKQISSSDFSTIFLFENGKAIEYLNENDSKQKPEKIQIEENIQKVTVDRIIEDIVSGFSSIYLLTSNQNAYGIGDNYYGQFGINTRIYERKPILMMRNVSKIFSGNTSLYVFLLNSNQELFGCGYNGYGQLGLGKSIIEEEEEEIKKLTKIQNIPKGKIIDIQCGSWHSVMLIENEDENPKRKLYSCGYWKYNLFGKNTYEFTEIKSSLFENDDDNDNIIDFSVGNEHTLILTSKGKFIVFGNNRYGQLGTEDTNDQLIPIQIELPKLRFNEEISNYHISCGFNNSFLYYSPFSSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLQEIISKKSIQESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIQITQEIINEIQIGIDYFQLNQTHPNLFDLLIKKFNNQNYNNKEEKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKS9</accession>
    <name>A0A9Q0LKS9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKS9"/>
    <dbReference type="OMA" id="WTFMQIF"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040535645" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5074446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="418" mass="47485" checksum="408BC12DE0A685D2" modified="2023-09-13" version="1">MKIISIKQLIIITLFLLIINNQNINKVYSHPIIIINDIDPSQIENLTKTSINGNECFSGYIEVNKTYGATLFYIFHPSQSNPLQNPFGIWLQGGPGDSAMVGMFMENGPVLISSNGTLYNNPYSWNKLLNMLYIDNPAGTGFSYVNNSAGYVVDEDDMANELYIGLTIFFQKYTKYFGNDLYIFGESYGGKYTPSIAYKIMSKGNILNLKGIGIGDGWTDPINQVTTFANYSVSTGLIDPNQKSEIEEIQNQCVNFIENQEWLQASEYFRGIIETITNMSGGVNIYDIREYGDYDYTSLSNFLNSPETQKSLGVNKTWIRHSSLVMKNLFEDMSKSVRSFVSALLYNNYKVLIYNGEFDLIVNTVGTLKWINQLNWKYIDNFKNTTAVTWEVDNKFAGLVRNYENLWQIFVSDAGHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LME9</accession>
    <name>A0A9Q0LME9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LME9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40980" checksum="EAFD5A10670A138F" modified="2023-09-13" version="1">MGVSNSAKKKISKREIKEYKMRVEKCSESILLVDNKANFIEANKAAVKMFKAKSKKDVLEKGPNGLAGPYQPAFKMPTMQASALVLKNAFESPDGFYDFDFLHVDCENKEFWCHVWVTPINWGGELVLQGYARPVSEPGITKTFDLSEEAAFFIKPVAEKMLQAKSTSNSKTETDSQTDSFIGDDFKTTTELSDTENPVNFSEVTSQTDQERKPKTSSKKQKETINSSFPNVILFDNDEDEIQLENRIDKIKSVVRSHDNPVLEKTVVQELNEIKKIFSNSTQNLEKKISRLVDKLQKERNQHQQKYSQLESHLQKNLSKSQEAQNEYEVLFSKMKSIQEIFDDKVNQILNPKIEKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMQ0</accession>
    <name>A0A9Q0LMQ0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_06370</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="FRINCKN"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030908">
        <property type="term" value="P:protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="884"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1080"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="145"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="280"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1416"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="814"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="283"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5076371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1474" mass="168770" checksum="C847EB5EB2C23B28" modified="2023-09-13" version="1">MSQKVDYFANVDLSSGFQVKKPKTNKNSNSNSNSNSFINDKGNNNFEGITNSQFLSNPIKNKNNVNIFDKLKAFQGALPTTVNPLSTNLLPKTMQNSSNNLLNSPKSTKQQKQQQNLSNFNNPSLLNSPNKTPIIFQSNSQIKIQNSNSNLNSNPNPNSNSNTNSNTNSNTNSNTNSNSNTNSNSNSNSNSFTKNNSFQENSLYKIQNQIIKKPVQIIYANHYRNQLENISFLSHVEMEEMNLEELSRKIQEFAHIISLIGNQVNEMSQIMESKLKRGILNHNSNNSNNSNNSNNSNNSNNSNNSNNPNNSNNSNNSNTSNNSNNSNNFSNYFSNNSNNSNNSNNFSNNSNNSNNSNNSNNSNYFSTNLNNLNNISNNLSNNLSNNLSNNLNNFSNNLSNNLNNGFVSANNLFTISKNTPNFTEIEKTPTYENKKDLRQQLYSNISTSKITSFGDETSNANIIFSKNTPNIGTFDDLYDNDFNNDFTEKPRQSFTNNQNFQEFDRPKQELDFTEYEPVNVFHSQPKIMTEEEMKSHFQFLMSDEKEKMKVNTDYDQYRQKTFSWSSEIQKTMPLFGISKFRTHQQEIINASMLGKDIFVIMPTGGGKCHPKGTKVMLINGKMKCVEKVRVGDKLMGEDSKPRNVIALCSGKDQMYRVVAETGEYFDVTSAHLISVVDQKTGCVFDIEAQNLMNLPLQIKERIRLFKVQVSFEGIKSKPMKISPYKAGKMLFRINCKNEFNTKIRRIPSVYKYATQKQQMEFLWGIIEGSIEIWEDSKFPDRIILSRGNFSGSKWRKDVQFIGRCIGIEIRIRKIYIDEEEIEKLNEKMQKHERRKHNGKMHKIWVAEFPQNYINNRKQTGLKPGTHYSLRKFQVYPIEEAEYYGFELDGTQRYLLEDFTVTHNSLCYQLPSLVNKGVTVVVSPLISLIRDQVMYLKSVGIPAESFNTGDEEHIYQSLERSDEVIKILYVTPEKINSSRRFFSLLTRLNQENKLQRFAIDEAHCVSQWGHDFRPSYKDLQELKRRFSGVPIIALTATATPTVMKDVVQILGINGCEIFIQSFNRPNLIYEVVPKTKKVNTQIIKFIKSVYPNQTGIVYCFSKGDCNRLASEMQKSGIRCGIYHRDDSERDDTQQRWLNGEIKVVIATIAFGMGINKSDVRFVIHQTIPKCLEGYYQESGRAGRDGKPACCRIYYSSADKIRIAKAILSNDEESAQNSLHSEYMKTHQLHLLESMANYCEQNHKCRRVALLKYFKEKFPSSQCHSSCDFCRESQENEFPLKDVTDDSIHVINTIKEHQNKNKKQLVRLLNTNKRKDSNNSPVSLSQAYLNTLFQLLVVKKILKEEFSLFSTRSSSSKCVTINFLLGPKSQDVLNGKKKIFLIKKDLRTVRSKKNKIRSEDIDGRTLSDSNQYLKQNQNSNQNQSSYFNQNSINSQNQERNGNVLNQNLQTDLSNFADTGITNSHYFINSNFINSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMS8</accession>
    <name>A0A9Q0LMS8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beach domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_08010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GVCHLIE"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="12">
        <location>
            <begin position="2355"/>
            <end position="2510"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="11">
        <location>
            <begin position="2530"/>
            <end position="2821"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="2919"/>
            <end position="2956"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="2966"/>
            <end position="3007"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="3163"/>
            <end position="3223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1564"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1727"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2247"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="2318"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1576"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1588"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1736"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1752"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1774"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2255"/>
            <end position="2268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2270"/>
            <end position="2280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2288"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2309"/>
            <end position="2318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5074655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3225" mass="378398" checksum="617756E9B9A78875" modified="2023-09-13" version="1">MSWFRNLIKNKDKKKNKKNKNQKTSNSNEKTIFEENTKPKNIDSKLLNLQKIQEIRQLWNEFSQLNDKNSQKNLLNQIVVMFYELFCSQENNSITEFGDTRNFSFVIAKYFINLLIKLTKEINSSDPNLLSKIINFPINHQNNIYYFQLSATLLLLSQQEINIESLLNSKLTLNLLNFLKLFSQFDLNQISYEENNNQEKNENRNETENDFILLFVDILQENSKNQKSIDQLIQSDTLIILFEIINSNSNKNYLIKKLQNVSQLILSQFMNENLIFYIQTKNIIKIQLETLSETSKLSSFRISNSISFIINLLISSFPKTHKFFDEFIKLSGYKLFGKIVADMLHNKSTSISDLESIIKNISSLVFCGDFNIKSIFDQEKEINTNFSIQNTDALQILSNIFLLSANSSFKQLSLFTLQQLFLILQKNPHNYYVMSQSKVIELVLAKFPLYENEIQVDLLKIIKFVASSLQITPKLDLKVLIQLFKNNPKIEVVQLITNLFKDLISFKNEFKTIIFQLGLFNSIYTYIQKEISQNKYRYQKKSQSTNLIIFYIQTIEFFVNDNLENMNLLYEKKGINLLFELIKLKNYQQLVLSLIESLAIQDKAQKLDIIKLILDEISSMKITQLSLYTAFLICLTSIFKKNQTSQVHFQKIQGYEIIFNKILPESLVKIQNIEAQNQFLQNLFQMIICSLSDSKINQIHFHHIYTHEKLVNSITRSGNFHSLLKNSQKYHLFCLLLDLSILSNELLHTNNTLVPDSSKLKIVFPHPIMVVVDLMKDIPLESAAELMTKILVLAHVNHINKTKMNSVKISTLLMKKYQEFLFDEDNLLNPVLTNFLQMIQTSNSSIKEFRKFFRLFKKNKNIPNSILSAFKSMIHDGNQPSFIEFDLQESSNAKLSLEYSNDKSWPPSSSYSLSFWIYFDSFGEIFTQKKENQPINLFSVFSSKNQLEMIFSISNGKLSITSSSNSSISFDKFKFREFHWYHAVIVHSKHKFTQSSITLFVDGSSKQTRKINYPNSIQSPFKFVIGNENISENPPHIKWKLGSCFLYESALSLQDIQKIFLLGPNYSGSFINPFSQFTNFQIVNNYIVDNLFKNGENFEDIMKQLDLSIASIPIVNEKLIFCLSPIHTKKVLENILNESENEKIEEINSQNKESNYKNENFLKQSLSIQNLAILNGKPYGILSGNANAFLSKGAIMQISKIGGPIICFLLFEKITTEIHFQQLFAILVNLINLNYTNLKEFERMNGYKIMSHFLKENSHFINVNIINLLFELIGTQESTNISSLIKNLGIIEIVCFDQEIWSKTSNLVQEYFFAKFQTFISIDNKNQDFNINQLRKLRFVKYLFKLLRENIFDDSVINKIVSLLDLIFNHSLISDEFSLFQTFITSTLNYKQEKSDPENTKFQNIFAKIHGLLLDMIFGLIVKNGTKENNHELIVKILTPNFALSIIEHSKALSTKTKALKLTTALLLIYPLFFQKFKQNYGFPILTLILSKIEQNSNFYYYLFCLLFGVSEILDKENFEVKETNFKEVLLNNSSIFKKTSQIYCSEAFFLILTLLREKKEQRKKENLKENENENENQNQNQNQNQNENEKENEKENEKDLQQNLLQLAKTLPYLFKKVRRKTITKNDELEEVYVFPKIKKRRSKRRQSETRSITQRSHISPYSKKLPKILQLQIQQQNEIIKFLISFFNNYPNFRDTFKKLEFIEALVEIIFINYSEIQMEVDESLNNNNNNNQSKEDSSQIEKDTKDKQQIINTELSQNQTSKSQEIPLFKDQTKQIEQENEQKPKLDEENESKSKSKESLKQDEFLNEFDIIQINPKSQIINKRLKRIIFNHPTTLLIFDFLTRLATQSISNDQKSHHIIESILDSPPNYVPEQIIPSFEQDLFISIMEHLEVNIRRERFSSSKFSNNISKFSQLVVDKMNNEIFQRKNRFIFQFFVTMIKLIIGDTLAKIEDLINFKSSKHQNTGLQSLYKGLNQAILFILSFKTFHKDELMKLLLLILKEKNIVMNPYNSDVEFISCFCLSLYRLLRSGEDEIIAKTFEIWKYFAKSQNENIKPLFVYKNDNKETKNLFSTMLEYMSNEKEFIDYLIQNEQEIHQAFNYHIVKAWKFYKEIKNKNNLEQVNSWISRRKTRLKNRRKKDRGDQEIHKRFQDYGKFHIEKLANFESNRNQNERLKLNDMHQYIVFEWEKFKKEFTRERGIWGSKKQDQDAKWKLDTNEGPERMRMRLEKNFNFRDYKECARYDEELDDNPEQDEKKNEEKKDLISKKLSSMDNSSFLNKKKLNGDSDDESSENESENENTKEIINENENININENVNVKENVNENENENENINEENQEEEEEDQRVLRMLEEGDHQILRKYNCSRVIGLESQPALLLICSNNLYIIDNYAVSSNQEIIEIDEKLSGLLSNKLIAFEIEEYSNKEPFTNSWTAKEKSNVPEMYDNYDKQKSSIIGHKCIKLPISDLIGVVKRRYLLQPIALEVFSGDGRNYLFYFNVKQRNEIFSQILSLISTKKNENRGYKFESEMIYAIRELSKSSSTQKWVNGEISNFEYLMILNLMAGRTYNDLTQYPVFPWVIADYESETINLKDSKIYRDLSKPMGALGENRANEFRTRYEMWEDPIIPKFHYGAHYSSAGIVLYYLIRLEPFTTQFVHLQGGKFDHPERLFHSVQKTFLSASKVTMSDVKELIPEFFYLPEFLMNQNKFYFGKKQSNDLVDGVTLPPWSHKDAYEFVRINRQALESDYVSEHLNEWIDLIFGYKQRGKRAVQALNVFYYLTYEGAVNINKIKDRVELESILSQINNFGQTPRQLFKKAHPKKQKKFFTLSTEYSDDFNLGIFSYPNYLKFSVVKELNEPIGDIFSFGDKTFSVGNYKNILLAPNGVVSKYLSWKNIDFSIRIYSLDGDKLLSSQEGLHFESEITCLFVSSCGEYMATGGKDYVVNLWRIESKKSEKKTQDFNLLERFYGHLNKITCLFISRNFGIIISGSKDQTCIIWDLNKLRFIRQFVGFQDEISGLSMNNLSGEIIVCSGNEIRILTINGYELVSKIFTNEPVLEKISSVTMTRFSEWNNNHLYITGHENGKICFWQIEHLRTKEDIKEDTKENIKIRELKLIWQTTQSLSSVTKLFVSNDNSKFFSGHFDGKVLCWSLPEEGITTHWIKDKEVNSCQVCNKIFSVKMRKHHCRKCGRVVCKECTQNKIQIIDLHFFKPTRVCNDCYNQLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP95</accession>
    <name>A0A9Q0LP95_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine protease 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP95"/>
    <dbReference type="OMA" id="MRQWYHQ"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040108351" evidence="6">
        <location>
            <begin position="19"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="458" mass="52181" checksum="C63809DAFADDE9CE" modified="2023-09-13" version="1">MKVFYFLVLIFVLSSIQAYKHKAFHEVIQEKPSDPENVFWFDQELDHFDFLSKETFRQRYYVNDTNYVAGGPVFLFLGGEGELTDKWIQEGLTVELSVMYNALVVALEHRYYGESMPFDELKTENMKYLSSQQALADILKFRDLIMKKYSLPENTKWISFGCSYSGALSLWLRIKYPHLIAGAYSGSSPVEAKMDYVEYDETCEAALSATDSSCLNSVQTAFSSIRDLLETENGRVQLQQMFNTCQPIDTDDRIKLFKYNVIGAIQGSVQYNNAPSFPRLALCQAMNSATDKISAYAQLNNEMNGNLCLDLTYDFITNRTAAPENNGRPWYWQKASEFAYYKNSPDGSQIFFRDIDAEFHNKIVEIGFGEYLTPRVGFTNEFYGSKSPVVNDAIFTNGLYDPWSKLSVLKDIGDVSSIIYTSSGHCAPVYPFDPKMPSDVQKARNDVGVFVRNIILQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPB1</accession>
    <name>A0A9Q0LPB1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Structural maintenance of chromosomes 56 smc5 smc6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPB1"/>
    <dbReference type="OMA" id="TTRANCA"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="333" mass="39667" checksum="D2257689BF57B9BD" modified="2023-09-13" version="1">MQNSKIDPKQQQLQLSLKELARVNIEHKKLLKQLEIEEVAKTQMLQEKQKLQKQNSDLQKEIKNLTEKNEKLENQLKENQNQNQNQNQDQEYVIEQNLLDKIESFNISIENTDANSVVYVLLEQLSQQTENFSSLKSLNESLQQTLQQKEEKIEKYKNKSKSMKSEILKEKESFNQIQNEKIQLENQIKLLENQIQNQNQNQNQENQTKSPNQNQIEIHNIKEKYKKLKKENKLILEQKNKLENQVSLLNSEKSKIESKYQKYQNKSQSVKSELKKEKESFIQIQNEKIQLENQIKLLQTQNQENQTKLPNQIQDTSKLHNIKEKYKKIKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQA6</accession>
    <name>A0A9Q0LQA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQA6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="574" mass="68200" checksum="0E60458A3B971A3C" modified="2023-09-13" version="1">MNKNHNKNKKETNFHKLDTTKIDLELSKEVLNNIKQIFKKFQKEADFFFYCGKNRKIVACHKLILQASCPKIYLENREKEIDSIEFPNYEHEVVKKVVKFFYSGKIKIEMNNFEQIYKISHFLGLELLKIKVEKEAEKFINLENIFNLFCIFSEIKSNHLIKLCHSFIRKNVTKILSKEKKSNQLSKLDEAQFLNFSGIIASSRINKKKLIISKLMKTYQKKFQKSIQSINIQTVNFQSDPKTEIVNQIFFLLDWMKSHRFHPPPQKLLLPFDHQIQNLNQNIEEEFQNDRNQEDEIEEKKDEIKEKEKQITRYQNKIKKEKREKKKQERIKRKKEEEKKRKQQINNQNNQNIQNNQNNQNNQNNQNNQNNQNNQNISNNQNIPNNQSNQNNQNNQNYQNNQNYPNISTYQEGLQQTTYTIPDFNINRQQNFHPALDNLNDEEKITLSIQRLSEEKENEQVQADQCLILGELANERPQNQELIQVFGGIRLIIEAMKNFPNNTELQENALFAMKKFSIDETNQIVIRELFGIEQIISAMNKFKNAKKIQINGCAALRGLENKKSKNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQF1</accession>
    <name>A0A9Q0LQF1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQF1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="17156" checksum="A8228A2C239005FE" modified="2023-09-13" version="1">MSNFSNQKEKSIFSDPEFIDSTQKIKTNDIKNAQKQKQKQKQKQKQKQNQQNNNSNNKMTFDTLFSDEENSHWQTVPDLKKVTIEFSALVLSSILGLLFFILGFSLLTKHSTFAAFFLFLAIFMVISFLIALRNYNIKKQEENLTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRB0</accession>
    <name>A0A9Q0LRB0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Duf614 family protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRB0"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="147" mass="16562" checksum="24DA53A551340622" modified="2023-09-13" version="1">MFMFQPLSSEQAKSDFKKKANIFVGCVVALKVSSTIIQKVKPIRQFFMANDWSSSLFACFGDFKICLCGTFCPPYLAAKNKSGADGRDCTICDCICCPREYYTRQQIRSTYGFEESPVNDFLVMWCCGPCGACQDARELQTRGDMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRE7</accession>
    <name>A0A9Q0LRE7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-binding protein m</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRE7"/>
    <dbReference type="OMA" id="WELMENT"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="701"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="637"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="896" mass="102483" checksum="8D1C220552879533" modified="2023-09-13" version="1">MALPVRKCVLFRHGIGYFEREEEIEGDQNLVLSFKEDVMNDVLKSLTTYDDGQGYVSGISYEGIGEKKPNILINLDSSKSMSQLMAETQGAKVSITYGGEAYKGIILGIEAKKKTNDEKQNQVIETEIVSILTEENQVRSFDLMEVEDVEFLDEEIKRDLQHLLDVLISSKKKSVKNVTVFCKGKKKRNFRATYIIPLPVWKTSYRVMLGAKEPILQGWAIVDNTTEEDWKNIKLELVSGLPVSFIHDLYSPRFQVRPKIEVQDEAAFAPPVLEQSIERLQSFGESLEMEMAFDDMGGDLLSLQANGPPPMMAMSMMAPKMPSMMGRGMHRNAKPTMVSKEKKMEAFTQSVQPDVQTRKSEAVDLCHYSISVPVSVKRDQSALVPIYQGNFGGEQVCVYNESVRAKNPMSTILFKNTTGLILEGGPITMYEKGEYIGEGMLDTIQPNDEKLISYAVELGCIVSSNNGVESQSIHQSVVNNGILSTQKFYYYWRKYEINNKSTKKLDFILEHPFTYQTQLFNTMDPYEKTDSYYRFRFPVPPKQKIVFVVVERKQISDTFYLDNLNERQIVNWHSQKLIDQKTKEILQELAIKFQIRQNLSSQISITKSELNEHFQNQRRITQNMKSLRDSSDQRKLRDRYVQELTTSEDEIETLRAKIKEHEKNLRVLQTQLTKELNAIRYETFLNVPKAVLPQSQIKIRAEKLNQKLTHFHEKVDEALPSGFDEDYIRIGIEHSSELRTIHDKRETDEECIVRSNFPIPDSVKIYYFEMTVEDPGTSEAIGIGAVPDDHNLKGMPGWENSIGYHGDDGNLFFCDGKGQEFGPTYSKNDTVGFGLDRNTKNAFFTHNGKLIKIVPDNKFSLFSKTLYPAIGLHSKNAKISVNFGTIPFLYKLESKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRV0</accession>
    <name>A0A9Q0LRV0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">von willebrand factor a domain-containing protein 5a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRV0"/>
    <dbReference type="OMA" id="FNVIRFD"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049886">
        <property type="entry name" value="CFI_box_CTERM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041770">
        <property type="entry name" value="CFI_box_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="4">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="298"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="740" mass="83997" checksum="73C441AC41EB0B26" modified="2023-09-13" version="1">MFGLISKTQEDIPLVGVSVKAKIFDFVAKVVVRQKYENNYDHPIEAVYKFPMDEAAAICGFEAYIDGKIVKGVSKEKNEAQQIYDDALAQGHGAYLMEQETEDIFTLSVGNLPSKKQVVISIFYVAELEAEDDDQIRFVLPTVISPRYTPPNKNLEEKAERITPKYVSSVPYGLKVDIKVGMQSKIVNVLSPSHDIDVKYPSKFTAAIELGNPKKTTSLDRDFVLKIKTEQPFEPRVWVEGSKENKPEKNEKEKKKKKKKNQKEKHEKKPKKDQKKHDPGMMVTFYPEIKVEDKFEMEMIFVIDRSGSMSGDRIRSASKTMEQVIKQLPDNCYFNVIGFGTKVEQLFDESVQISKEIREKALTHVSIMQADLGGTDLHKPLEQIFSIIPAKNRPRQIFILTDGDISNTEEVMKMIRRNSSTARCFSFGIGAGASRELVNGIARAGNGKAVFIDDSGKDLEKKVIKQIQRGMQPALTQIKIDWDGLNIDQAPKVLPPIFNHDRFIAYGFLADDINNIKGKVVKLTAALPTGEEVCFKLSLDSVQIIYDDIIKTLAAKALIKELTMADIEDKDKIVELATKYGLASKHTSFVAVEERDNDGEIEEMELVDVPSLNPMDYQEEYSAMRSAPMLNQSSDLCYSAAPKYSRKKSACFIATAAYGTSMHPKLDSLRWMRDNIFPNKLTQFYYYVSPPIADFISKHDSLRFLVRVLLWPLVYLIDNPRSFFSFLTIFILIFSIYLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRW3</accession>
    <name>A0A9Q0LRW3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Maspardin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_05547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRW3"/>
    <dbReference type="OMA" id="NQHILAT"/>
    <dbReference type="OrthoDB" id="10264550at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026151">
        <property type="entry name" value="Maspardin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913">
        <property type="entry name" value="ACID CLUSTER PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913:SF0">
        <property type="entry name" value="MASPARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="48"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5077857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="49928" checksum="5389BC5BC655BF44" modified="2023-09-13" version="1">MKSLQESYKNFLSSVPKKKVICIIREVEKQWVVFDCNTQEESDKTKAPIICLHGVAGTADIFFKQILSLSSRGYRVISVQYPPFDSHQDWIQGFNQFLNQYKIDKFHLIGHGLGGFLAMLFASKYDGHVLSFIFSNSYSTTSYFRTGKKAPKYTLFPEFMLKKKILSTFPKGELLSNIADSIDFMVEQVETLSRAEVRSRLVLQGEPGVGRLLFYPQERILLLNSLDSTDYTDEMRQAMQKKFPESKVAEMRTGGNFPFIGNYEEFNMFVLIHLRNVELMTSDPKNEGNLENFLETQNNKESDNENNNNNNNNNNNNNNNLNQEKDKNKDNKVKNQKDNKDSKEKKKHHHHHHHHKKHQKKDEKPKEEKPKDEKPKDEKPKEEKKEDKQEKDEKKEDKKEDKQDKKDEKKEDKKEDFENIFLSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS49</accession>
    <name>A0A9Q0LS49_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease t2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS49"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040370962" evidence="3">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="228" mass="26778" checksum="E71A209C7E501F09" modified="2023-09-13" version="1">MKIILFIFLFTLFSFSFSDPDWDFWLLNMQWPLADCINYANCSVPSWYSSFALHTFEPRTDSNVPVFCDSQYPFNISEISNITYSLAYIWPDFWNFSYPQAFWKTNWEKHGTCSLSVLKTEYEYFYTGYQFRESLDPTTWLWKNNIVPSNTTFYTYDQIDQAVTQAISGLKPTISCNTYLGKTILHEIGFCYGKDLKLFSCSDTLRTNVGEKCGNRTSIWMLDFPNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSP0</accession>
    <name>A0A9Q0LSP0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSP0"/>
    <dbReference type="OMA" id="MITNIPI"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="339" mass="40564" checksum="09F58AC387E10B8E" modified="2023-09-13" version="1">MITNIPIIGPIKYSQINFEDIRLMLQFQNLENFIFSVFIPGSDISKSNPSVQERNIWGYPVYDPSSDIVAILFHSDACHDEIQSFGGIATFQFFKMSDNQSFISKRHQNIRSRTSKHKNYGIMIQEFNFIQSEDEIPDHFLSLEEIKRKFFIHKFKLTGKQKFFLSHDHIVFVKEKNGKLYLKEITKHQNSKKAKKLEKKNKKRKKYFDLNVVFSISNDPCFKYSLDLMKDKGVETEKLTCYRFDEEVLYIETIDERFELARMNQKFRLSRLINPKPFDIHIISKQFDVPLNDKYLEVINNDLDWLSIKWSEDSIYFNDFIIYPKKCFWIKKKKKMDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSV1</accession>
    <name>A0A9Q0LSV1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSV1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="95" mass="11419" checksum="FBC4E79CF8B15B1A" modified="2023-09-13" version="1">MKNLIAFFKLQVFKPSKIFFRFLISKIKETFNFIKNEFIPNVVKPIIKNLIAFKNSTFEFFVSVKNSLVSLYFQVYQFITNFVKKFTTKKEVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUQ3</accession>
    <name>A0A9Q0LUQ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolases superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUQ3"/>
    <dbReference type="OMA" id="CTNLRIN"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008536">
        <property type="entry name" value="DUF818"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05677">
        <property type="entry name" value="DUF818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="410" mass="47439" checksum="D5FBCF930E87FCD5" modified="2023-09-13" version="1">MGQITNQLTFQPPQNPPQLPKTNCEFVKTKTKKKYQIPVIWFTPQTIDFDEQEIDNLENTNIDIDTNTNIDINIKSKSRDDITDSWNKKEKKIKKEKEKKIKKEKEKEIKKKEEKKLNELDIHNRFTFIFSHGNAESITFLDKWAQIFSNRTNSNILLYEYCGYPFTEGISTEENTYLSAEAAYDYIIEKKGIKENQIILFGHSLGTGPTIHLAMNKKCRAVVLMSSILSCVRTVVSPKFSCNSIDMFVNIDKAQFVKQPTLVIHGVDDQIADFSHGKKLYESLPNTVKPLWIEGAGHNNIQDDFADIFYKRILKFLEDLLNYSENQNQIENQNQKENMDLLLNINSFSNSNSNSNSNSNSICEQKSSNFSTLSDFLQENKPQKGIFSACKRSTHTRFFKLDDKLWEDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUS9</accession>
    <name>A0A9Q0LUS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUS9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="224"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="456"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="621"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="726" mass="84758" checksum="1AEA15DD2C5838ED" modified="2023-09-13" version="1">MNDIWFFGLNKFPKIFQNEKEKIINPIKLNFYKKNKNKNEKNENQLELNFDFEFDHEFEFEFEFGFGLRIKSIGSNETTVIFLFENGKAIEYLKDSNENPHKIEIENIKSISAGYKVTSILTFEGNVFSKGEIINPNDPKKYINISSLIEDPNDRIIQDVVSGTNSIYLLSSNHNVYGIGSNNFSQLGLSSIFSTRNPVLMMKNVSKMFSGNSSSSVFLLNSNQELFGCGWNDFGQLGLGESSAKNIPELTKIQNIPKGKILDIQIGGGHSIMLIENEDDQNQNQNENENENKIEIEIEIEIENQNQNQIQNQNQNQNQNQNQNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNENQNENQNQNENQNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNPKRKLYSCGYSQYNGFSSSTNKTEFTEIKSPLFENDDNILDFSVGCLHTLILTKKGKMYGFGNNLYGQLGTGNTENQPIPIQIELPKLLSFDISNYHIHSDSFNSFLFCPIISSLGLDLIKLFERKEFCDISFKTINPNEIIEAHKLILKYRLNQNQIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIIKKESINESMKRIYLNENENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVRDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIINEIETGIDYFQLNQTKPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUV1</accession>
    <name>A0A9Q0LUV1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytokine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000036">
        <property type="protein sequence ID" value="KAJ5079135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUV1"/>
    <dbReference type="OrthoDB" id="5985842at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040461439" evidence="3">
        <location>
            <begin position="23"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="250"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="695" mass="79048" checksum="A2470FB5787B6A6D" modified="2023-09-13" version="1">MKLNLFFSFFFFLIINIFLIQSNQNQNQKSIQSSLISILPILKEIKTLTETTRYYSSFNEVWIWNLLDQFSGSSGDYFGWSVSIYENVTVIGAYSANQAFIYRYNGLIWNQEQNLNESASYFGYSVSIYENFTVIGTDGANQAFVYQFIQIPQVNIINCSSSFSSFDCYWDEIQIPNLKYQINYGFDWIDIDYPILEDENVYYQQFNSSIYDNITGNEYYSIQIKACDNETSMKCGESSSFINLSTKIDSVKYFQLSNPSNNSINVTWNYPNVQINEGIAHLDHYNLSYFIQSQPDLISFISVDNSSLDYFLNNFESENDYNISIFGCRTHECEGDDKGEIVESSISLLFGEVTNLTCSISNLIDINCNWNQPIIKCSIPFYYNLTYQSIYQNDSGNYQPTSSNQQFTVQFQNQEYQINISACNSNGKCGYISSISIKTDNLTSPTIYETISKIEEIEFNFTKLTNANNYSISLDNGTNWQKFTSLDLSGNEIIGIISEISGNIEYNISIRGCIDLNCETPYLGEPSSIISTRAKLGNITSLNCYSLINGFVCSWNSLILSGGLKAYSFTYNSTSICLTNLINYYSISGLQGGEYYEISVQQSSTLNCLNNEYSGINSTTSITILSPYQPTQSTDSNNSNTTAITIGIFIPILIILIVIIAILLYQKKTRTKKQKQTKNLNQKQEEKELQDNLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUY6</accession>
    <name>A0A9Q0LUY6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUY6"/>
    <dbReference type="OrthoDB" id="9450922at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="163"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="209" mass="24067" checksum="5F926D1519E0B708" modified="2023-09-13" version="1">MNIKIELQENIFELIEIQLNWTIKELKDLILKKIQINFPQFSLVFNDKILEENKTIEFYNITEGSIIKIKEVNEKDVFGLLNGFGGTGNPPPKISTLFPTIESLQEVSNDSLMQDFFDLVQDKPEYIEELVSNSPEMQILLKNDSDFFEVIHDSKLLQSSILQNEQNPFQNQLQALIEMGFQDTNQNLQALITTNGNLENSIELILSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV15</accession>
    <name>A0A9Q0LV15_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proline-serine-threonine phosphatase interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV15"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14890">
        <property type="entry name" value="Intein_splicing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="7">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="289"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="6">
        <location>
            <begin position="571"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="975" mass="115237" checksum="23581E291A0CB095" modified="2023-09-13" version="1">MNDLYNSLLSKTQQMVKETNQICELLHKRAIVETKYSEKLTETKNNFETSIEIEKGIHGLMSEIVFSYAKELQNRSINQDVLGKFFEEHYKQISKLSKDYENEFQKMLFKLKRNMKDYEKYHLENRKSCQKYMEKCLSQESIFHDLTSKTGLIQRNFPKIESKYKMAQKEALNSQKEYDEIYNQLTKSYESIKQEYELIFQKMVQFEKDRSNLLNDFSKHYYLFLEQITNDTLQQSKNLLQRFESFNPEKEIENGIKSIQETKTTGIQENIPIYQPKSLNPENIMTIFSVVETVIAKENFEAIEENELSFQKGDKIDILEIDESGWFFAKINDKFGFVPKINHFQTPFLNEQLKIEEGKVLNFWKKESPINMLTFRLESGKSINITQGGKFLILEGDQIKWKLVQDLEVGEFIATSRKIKISFPKNLQLFHLVSNDVLLQNNFEFIPLEINRIIQQFEKNPKILKKIQMNLKENQVFQLFLLKLNEEISKLGKKELIDKFSQEFPFILKENKERKDIQVSDLKIFSKFFGNCLEFSSVFKMKDNSHSNSKEIEIEIEIEIPKEFNQEFAYYVGLMFGGGFIYSRKNKKEIHFCNKNISIRDKFSSMTTSIFKIPKSKIYSSSTRVDFECEVLLNLLENLGIQKVDRLHKMEISNFILSLEKNLLQHFLKGIFDGSDSVVIGTKKQKSHSNQENVYIQFTTLSKKVAIFLQMMLLRWEIQTKFTKIKRVNLFGNEKNTKNTKNMNNIKNTKNIKNGINIQNSINQKKNSKENQEFNFVIKNSRKTFQKENENFPKINQKEMNKKSRNSTSRKEPKITSQNLNHFQLKIEGKENIEKFQKIINFRSKDQKEKLEEILKQKKWNRTLKLDFIPETKKLLATTKKELKSFLTPDLMLLYSSKIETRQKLQELIQKTEFIIEKSTEKKNIAFENLKIFANSDIFWDKIISIDIGKPNEKFVYGLSSTEDQLLANGIFVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVT6</accession>
    <name>A0A9Q0LVT6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVT6"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="370"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="475" mass="53972" checksum="44F3C8B922ECE0E4" modified="2023-09-13" version="1">MEETKKIIELLEKDNPKKALKLIKRNSSLNAYGVGENGDTLLIVASRKGFLEIVQEILKSGPSINAINDGEFALYVASKKGYEEIVEELLACKIFVDQRNKNGETSLFVASKKGHLNIVSRLLRAKANPNLFNNENSALQKASLKARTNIVVELLKFNADVNHQNKGNTSLHFAVMSQNEEIVQILLENNSFVDMKNFKFTPLQIASRLSNINIVQELLNYGASPVVKNIGNSSINLATNPEIKHRLKCYTSYTDDFISLIDETISSDVQIECLDGYINSVSQLIEIRLGIPISNFIEISKKYQKETILKILKWVHGREWELLLESEFEFSNMKKILISMGIEEKRILLNGGRKGLLRDMMKIYEDRKSADFSIFVSGEEIKVHKFVLFCRSELYKGMFLCVQNDKSNQAPDLSGRSFDAVQNLVKFLYFDHLDPNISVNTAEQLLDAVDYYQLNNDSLLSEEVWDKLSNQFDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWY1</accession>
    <name>A0A9Q0LWY1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWY1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="147" mass="17279" checksum="B6E03CF1BA98443C" modified="2023-09-13" version="1">MENKEKEIEKEIKEILKSLQKENEKEISIQKIFEIMKQFPLNETIQETGFLIFKKILDRNEHKEKILKEFENEIETIIKTMNNFPNNESIQFIGCISFGQMKSQNQKKKATDTVIKSMNNFPNNQFIQADGCITLGDVGFRNEKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYZ3</accession>
    <name>A0A9Q0LYZ3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="3 7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_03900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3 7 9"/>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYZ3"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000001">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003591">
        <property type="entry name" value="PRK05254.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="58"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5080415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="235" mass="27263" checksum="4273763F1CEF60AB" modified="2023-09-13" version="1">MDSFSVKGFEMLMEPSWRKILHSQFNQPYFKRIVDFLIQKEKNEIIYPPKNFIFEAFRLCPFDKIKVVIIGQDPYHGKGQAHGLAFSVQKGIAIPKSLHNIYKEVGDNYKTFKKPKHGNLESWAKQGVFLINTVLTVTEHKPESHKKSGWKEFINEVIRIISKKKKHVVFLLWGRHSQACASLIDSKRHHILKAAHPSPLSSKKFFGCKHFSKTNEILTKHSLEPINWNSLNESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4C6</accession>
    <name>A0A9Q0R4C6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger ccch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4C6"/>
    <dbReference type="OMA" id="KMIRCAM"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="745"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1267" mass="157799" checksum="F427C9E806629CC3" modified="2023-09-13" version="1">MSNLNSNNNQINTDWFFLLAIKLMNKSNFQSQNQFINSNTNFQNLRLNLNEKSKQNQKKKSVGIISPFFSRFSKQKKANSIKNPNSIIKPNFYKQNQIKNKQKRKIKENHFQDEKIEQELKRKKLNKKKFNQKNIFKGILTFNNDDQKIKTTDKQNERRNINLINQINLFQGFEDEFENDDKNTHFLFNKNHINSNPFEFQNLLFKNQSLNNFFRSKKYLKNFKNDLENHYIYNYNNEENSKYLHSISKKIQPYYYLKDESIQNQKNKENKKKNLEIDKTISDNLISIDDEINFENLLDQMRNEYQNENENENENENENENENENENENENENENENENENENENENENENENENENENESENENEYENESENESENENKYQYQYENESENENEYENENENENENENENENKYQYQYQYQNENESENESENENENENENENENKYQYQYQNEYENENENENENENENENENQYENEYENESENENENEYEYESENENENQNQYEYENENENENENEYQYQYQYQNENQNENENENESENENENENKYQYQYQNENENKYQYQYENQNQYQNQNENENKNQNQNEYQYQNQNQYQYQNENQYQYQNENQNENQNQYQNQNQYQYQYQNQNQYQNQNQNQNQNQYQYQNENQYQYQNQNQNQNQNENQYQYQNQNENQYQYQYQNQNQNQNQNENEYQNQNQNQNQNENQNEYQNQNQNEIQYKNENQYQNQNQNQNQNENENQYQYQNQNQNEIQYKNQNQNQNENENENEYKNENENQYQNQNENENEIQYKNENQNLNQNQNQNEIQYKNENQNLNQNQNQNEIQNENENQNLNQNQNQNENEYKNENQNQYQNQYQNQNQNEIQYKNENQYQYQNQNENENENQNQNQNQYQNQNQNQNQYQYQNQNQNQNQNQNQNENQNQNQNQYQYQNENENENQNQNQNQYQNQNQNQYQNQYQNQNQNQNENQNQNENIFEFENDFESENEFQNKIEIEIESENEFENEFKNEFKNEFEIENEFEIENEFEFKNEFEIENESEDDFENDLKNEFKFEFENDFENDFDFENEYENEYENEYENENENENENENENENQNENQNENQNENQNQNENQNENQNQNENQNQNQNEYENDFGLEKNFQKIITKKQKQHQYNRINSLSSFLKKNINLSTEKKLDIIYQFYPDLINGWNQETFEKITKEKKYPKKIQIDNRIFPIWNQAYYRTSNRYRLKILSQKMRLEITNFLIKKLHFHLDKNVSKKGKTILIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4Z9</accession>
    <name>A0A9Q0R4Z9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein fmp42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_02775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4Z9"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1108"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1108"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1193"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1224" mass="142589" checksum="76ACD585CE30001B" modified="2023-09-13" version="1">MEKTCKCENCTCKDCKCTMKDGICTCECKSREKVEKKKCNNKDCKCENCNCKDCQCKDGICKCKDCQSKDCKCDNCTCKDCQCKDGICNCKDCQSKDCKCENCTCKDCQCKDGICKCKDCQSKDCKCENCNCKDCQCKDGISSRNQYKSLCSENASIEDDLCFEQKKRLDLIFATCIGVIGISSYVWGEFHDRFGPRKTCILGSSLLLSGSLLLIWANSKTFDSYFPGFYLISSGGVAINFGYVSIANLFFGWESTILTIFSALYGASAFIFLLFRNLYEKGISWKAIFIGYSVFLTIQLLTAFLFPNKPFPRINKNDLNKNNNKVYGSLDSENQLIIEENHQENENFYLANSNLNKKENLEEETSTNGTKKSFDNDVDNVNENYSQEMSENSEKIIDAKNKETEQNEENLNKNSNNNNSDLQQEKQNQNKDNKTSQSNDKDSILVDKNEEVSKEKQNSIENIKNEVENKIEEYNNEEQVKDMLLLEKKNEEDEPKKDGLIKLLLTQEFIWFTLFLSAANLIIVFYLGTVEMQLESIDSQKSKQLTENFTWFLSFGFVMTPIFGVLLDKFRTWFCFIIVEMTFIFFLIFASISNIDIQYITFILISIVKPATYGLLYSYFGKLFPFKHFGKLTGISVFLSAIFSLLQYPLLIMTSTWFHNKYIISNAIQFALIVPFFVLISSKISPKKFINVEQHYLSLKQISSIFNEFPKIQSQKKNLIANLFLERESLLNQTFFQYSLIGTTSNSIEFHNQSFQSFSNFQQINLFRLNLSNIYELTNFLGIKTFNSSLNIGNEALSEKRIICNLVYGESNENQNQFENQNQFKNQFENEIQFENEIQFENENQFENQFENENENENENQFKIQFENEIQFENENENENENQFKIQFENENQFENENQKNAFEYDLYGFPDQITNDLNSIIIEGHAHFFNPNDNIIFYGLQDIFASSQFQNLEESDNDEWSDLSGELETTEQVKNEDVQKWFETSFKVSDSNPQISQTQNDIDNSIDLDYDGQFPFFDDSGFGTKKVELDWVSDQIVNFENSDSKFIGFQFSDNFNENSSKVPDSVGLDYNGQFPFLNDSEVITKNVEISWSSDEVESFEYEMIEENENEYEDENENENENENENEFENEIQFENENEIQIENQNENQIENQNENENQNENQNQNQNENENENENQNQNENQNENENENENQNENQNQNQNENQNENQNQNENQNQNENQNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5D9</accession>
    <name>A0A9Q0R5D9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ragulator complex protein lamtor2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5D9"/>
    <dbReference type="OMA" id="WAAYEKN"/>
    <dbReference type="OrthoDB" id="271745at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000004">
        <property type="entry name" value="ragulator complex protein LAMTOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="123" mass="13536" checksum="3E7FA47C43759692" modified="2023-09-13" version="1">MLKPKLLTKTLQQTNTDGINGTMLFNSDGSLIASSGDRDKNRTIAAITANIWQTYQKKSNDPLINSDLNVVMINCKEGKVIIKEVCKMFLCVHSGNDVPTGILKEKLISLAKFLEPSLSKIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6S1</accession>
    <name>A0A9Q0R6S1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6S1"/>
    <dbReference type="OMA" id="HERIGHT"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="270" mass="32404" checksum="EAD22CCA071EFEBD" modified="2023-09-13" version="1">MKKFQRTKRFLLPSDDFFLDGNLEREAFVKHSVSEIKIEELEKLFIDSNNPKNNGKKNEEQKEDDEENQEEKMILIECQFPGCESKFYSIEDYQNHYDHSHRNTCYSCGKIFPSEYLLDLHVRETHDTLFKLLSKRKPSYKCFVETCNATFWSPKKRAEHLVHIHNYPEKFFGSLRSVKKIDSFKNKVEQAKLKKQKQFSEQKKNNSQKVEQINPKKKVHQWNYKKKKQNINEKNMEIEEISNKLSKIHIPDEIHFGMKRGLRKKHFGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7E4</accession>
    <name>A0A9Q0R7E4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7E4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="251"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="371"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="532"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="653" mass="75824" checksum="01478EAEAE534D31" modified="2023-09-13" version="1">MNEILFFGLNENPKLIKNKPNKITKPIQFKFENENENENEKQIKQISSGNISTIFLFKNGKAIEYLKEDEKSKLSKNEIKIENLNQNENQLDQIPTINSQIISLVEDDKSIKYLIDKKEYSPDPEKIQIEENIQKVTVGSQNVAILTKEGNVFAKGKDINPNNSNEFINISSLIEDKNDRIIQDIVSGANSIYLLTSNQNVYGIGLNNNSQLGFDYQILPKTEKPILMMKNVSKIFSGNSSYFVFLLNSNQELFGCGDNGYGQLGLGESRNEIEINKLTQIQNIPKGKIIDIQCGYWQSIMLIENENENENENENPKRKLYSCGHNGFNGLGKNEDTYEFTEIKSSLFENDDNILDFSVGSYHTLILTSNSKLIGFGGNSYGQLGTGDTEYQLIPIQIKLPKLRFNENISNYHISCGENNSFLYYSSPSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNEKLKEIISNKSIKESNQIFEMIYSNNSNINPKLYFEIKEIINSNEKIEETMKRIYLNEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTKDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDKIQITQQIIDEIEIGIDYFQLNQTNPNLFHLLIKKFNNQNYIQNQNQKKEKNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7S6</accession>
    <name>A0A9Q0R7S6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger c3hc4 type (Ring finger) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_10879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7S6"/>
    <dbReference type="OMA" id="YNDIPTH"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="318" mass="37831" checksum="5D3AFD6D69AA9F95" modified="2023-09-13" version="1">MEIFSYSRKGKLPTICPPKRVEQQMHEQKYEETSRFIYQQLQLYFKKQFPEKIKSHIQKLCEQNLDFIDKTIMNEINKDPTFQTFNVSSDFFKSVKPSFLYPNLNEKNKENQFQKNKENSFQKHKENSFQKQKEDQDPQAIIAQFIQRRFNPSFMDYNDIPTHENNPEDIKKIKGIQKYKVTSAMIRKDFTCAVCRDQFKVEEDVALLPCQHTFHQSCIYDWFPISLSCPICRFDLSNKKIENENQIENQIENQIENQIENQSENQSENQIISKKSESTLEPVLGSQHSFSKFTKPDDQTSENLDLFDFTFIESDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7U8</accession>
    <name>A0A9Q0R7U8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7U8"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="302"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="490" mass="57566" checksum="52022D184A23D2CA" modified="2023-09-13" version="1">MFAEFSNQLKLSSDLTKLFNQNEENYFDFEIVCKWKNKEHLFKTHKSILSVRSEYFKGLFNSKMKEFQENKMVLEDVSKKTLNSILNYFYSGKIQINLENAVKILLFSSKYLIQELTDYISNFVMQTCQIEIVVDLLKIFESRNINLLVDFCYEFIQENFAQFIQSEFFLKLKESQLMQVLSKDNLDVNEFAIFEGLIKWGRHNSNIQNDLDQMDQSEKKTLSDSLSNLMKNIRFIEFSNQELENALQTGVIPEGMNKEIVDFQNFTPFVKDHMFNQFLQKKQRTSQYSLIFRKRSQFNSSIISKKKHIKYLKEWIGKNSIFSSLKLGFSTENNGWNCEKWHDICDDKGPTLVIIKTTKGFVFGGYSEVGWITNMEKWTSFFADPAGNIGDPNAFIFSLKNPQNSKPQKFTLEKEKQKRAIYYDYSKNGPHFGSNDVWLTKDMHTGFSFEFGFQYALPFGISFRSDQAKNFFAGENGKWKVATMETFFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7Y6</accession>
    <name>A0A9Q0R7Y6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tail specific protease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7Y6"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040333273" description="Tail specific protease domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="81593" checksum="B333D0C457B0A71F" modified="2023-09-13" version="1">MKLFIFLLIFILFLFSNTQLCYFESNSFYNYSSIIECAKSIPFQENNTVIETVNQMIEEYVFKDIVQNISTEFHHFQINLTEEFNQINQQMFSNDFDFQQSISDVFDSLYDAHTIYIKPQCYVSLYLVFPLQLSLKENQYSNPEVYVSGILANSDNIANIYESITGIDPRDYIGETIITIDNQDAWYYLLVESSKLSISKDPSSCLNEYLQNDFMALNLGYSPIPEKENRTIQFNSGFVDFPFIGMCTSNFSSQSDFQTQCLCNWIKCKNLEKSKSKNFKEKERKEVLSPVLEKRKRIKQMIREYFTSKDNENKNENQKEEQENVIDGSVIIFNTSDSVNFEVFTGDSGIQYGILQVISFMPDDLNEFGEIIDYGMEYIQSNNIDYLVIDLKQNGGGYIDLSYQLFHYFFNLTNEPIFGNYDFRHSNLNDQLFIKCAENENCKGDSESLYSPLLWYNQTEQQFNNSDYYTPGISYLRGEEVSQYSIPIHEVSNISYKSPIQFDKNHFILLSDGICGSSCAVFSSKIIQNNLSTTFTIGGIPNSEMGFNSFPGGQVYNSESLLYDLLIQFPYIYGITIDNPPTPFESDNEVSFTYREIYPFDTNEINNSTIPLEFMFLPTENKLNIWDFSNESLIYQGIDSYLNPIPSPTPTPAPVNGNSKSSKTGLIVGVIIVIIVIIGLLIGFATYRLKKKKNLETQMYSQLIDDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9E2</accession>
    <name>A0A9Q0R9E2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9E2"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="115" mass="13013" checksum="412DC1078FA94818" modified="2023-09-13" version="1">MGNVVSSLTFQPPKEVPKLDSTAKFVRTKNGFSIPLLIFRPPKEPTYKTSSIQNKYQKSISNSLPYTFIFSHGNSDSITLITDFAVDFVLKTKSNFVLYEYCGYPYAEGEVSFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9Z9</accession>
    <name>A0A9Q0R9Z9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rabconnectin-3b isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="YACEAIS"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1283" mass="147640" checksum="A32601C887F44158" modified="2023-09-13" version="1">MFENAIQFVVWNSVLPPKHEISVILVSQEPVHIITGTQTGQIFLWEINEKNNSNNSNNSNNSNNSNNLEIFPRALLLGHQTQITAITNTFFDSHKAFASVSIDGSFCIWKLDDGYCLQSKIELFQCSPTTIVTHIFNRRCVVAAGNSNFIEIANIDLLQIVQRINFDSWIESLSLYAIEGGDLTPTILTALGTDQSLSFWKLPSKNEMMQNKTTYTTPQILRRVIFPYSNPSSISFSPNQLLIIFSTKESIYIYDNSGIKKLYEIPSCDNLTWIKARFIDDNNIIAWDISGKGKIFKMPEIDFTQIPCLIEKFFGSEYKVVLVQDNKTHKLSLSEISFEESILQNENIKDKENDNITVENSDTKEKNPKTIKKFGFGFGFGFGFGFLVLRGSHHYNSKENNQNERECFNGEKYTISQFYLSEKRYIACGDSQGRLCVWDLDLIKKSISQSKKDFVKCGSIYLQKENVVCEPTVRSSLKHNWYMKYQKKCNRLLSWNENEIQLKNEIQLKIQLKNQIQLKNQEKDKDPFITCSIIVEEDLNELVLIQGFSDGTIEIKDIPFSLEWPVKFESEKQDKITALFSPQLKITKTNEKKNSILRPIIISGSENGVIYVRNRITRKTIVEYNHHRGRIRHIFSPPEKVGEILDDYFIVFGDDKVISVCSLSHFQILYLFGGFLSTPKKIFWRNANDFIGIECDDQTIYVWDLSTGKLDRILLSQNSINISGITNFNQYRNIFEKKWNHISSRTQFQDYLLGCAPLYPFAFREITHVTDIYIDNQESNNIIYVNVNTLLNNLVSNLKENPRELKGKLRLITHFFSWGLDRKFDEYIEKMFHIYTPNHEMAVGIIGSCQNISLMIPRKVDDQMASKLTISEQITAIFSIIPLALAMALSTLESSQMQQIGSEIALYYTEILRNKLGKEYVTPCLEFLCIYWCDDCVYIENAARTLIRSVISRMSPNQKSSLIEIWKKVLSGPLSETRRETGFLVLGIMCICSPESVSSTLFSQVCQNLLNMIRKKGRKAAIAIDLLASGFKNFQKFIENQEELICYLFNLICISDSTRKESARVSILLVGLHHPLLVLTSLESQIHMKNTLITSQETARLLTVLMIQKNANSIYPHLLKTVEILVKSMEVINSDSTLFEIDKSAITQLLKTFPMTDFDEDHQRLVVGSIDSKMTIFDFKLNHVFVPKQIHKNPISAVSFAKNGKLLASYSLDDEKIVIWRVRISLYKIFHELAKQKKIIQVPFKQKVKLTEQLDKMNLKWTSDNTISLTIKDFTFNFNIKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA30</accession>
    <name>A0A9Q0RA30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ig-like domain repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA30"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040264158" evidence="1">
        <location>
            <begin position="22"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="696" mass="78723" checksum="9E0775BBC59374EF" modified="2023-09-13" version="1">MNFFFLFFVSFACFFVLLAQSEVVLSNSLTFIPGETNVMGTFLDEDEGFIYFLDERNYKYSYIWKYDLNTLEFLNYTHIEEDYVNCGAIDFKNKFLYLATSNSHKFLKFNLTSFQVVDNATLNVSSGSQAIRVEIDIINQKAYVGFTAPITIVKFDLVKWGESSSLPLSGDRLSGSIIDIDNGILYVAIDSYSGNNATIYKIDLSTFTLVDSLKVNLPGAKFLNFGVIDSPTQMMYFGIDQTPMRIAKIDIKNFTSVGVLNLLSQSYCYGAGIDTFNRIGYFLAGNGYLMKLNLTDFSLIDSLHFSNYWVGAMAIDFSAKNAYIESGNSQFVRVNLTSLTEVNKTGLIVYTDPVFILIDEQNQTAYVCFNDHGGLIAKVDLQSFSLIDYLILGLSDDIYQGEIDTKNGFIYLFFFDNLTISKVLLSNFSLSETVSLDSGSYTILTSFDQENQILYLLYANSSNYYYLLKISCPDLEITDSLPLQENIFAYGLYPDPWHGFIYCWIIEYYGPGSGYFLYKVQLSTFSKVGQVNLTEYGVAHPVFDKTHQLIYFGDFSESIYRVDLINMDVMNGYLDIRWADFVSSFIESTDSWVFFVVNYYNSASGDFDIPVILQIDSSSNQLISNTTFDLVSSSIIDMYDPTTNYAYAIIPNSVPFILYQLSFPTPPPTPTPSPSSSQQILFSFLIFGIMMILGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAG9</accession>
    <name>A0A9Q0RAG9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pq loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAG9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="262" mass="30734" checksum="416E4910EAC00F0D" modified="2023-09-13" version="1">MQSKNSKLEGIQTLMIILLVGFFINRLINSFAYPFLNSFEAKNLIGLLVIISVQTIELLICFWIWKNRENKQFEETNFGQIESILNKLAIFEQILLIIKGFYDPLILHFQAYLLTIIPFTIFVLLIVYFPKQKEPSTKTEKKWCFSHSMKFAYLVLVFVIQSIIVSFVILFSWNHTNSQMFKNFAKNAIKSGFLNWILLLFSFIIVNLFNVLATKFDEVFARKKTKKWIIILNLIISFISLFSSIPQIALFSFVISILYRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB73</accession>
    <name>A0A9Q0RB73_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB73"/>
    <dbReference type="OrthoDB" id="10428994at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="90" mass="10079" checksum="377A9E53E7F8CB49" modified="2023-09-13" version="1">MDTVGKKITAGVVITALLAAATYPLVKSKKETRTMSTVQTPKTQKFNHDEFDQCDCKPLWECMQSGGDCTQLEKDLRNCVNRVKSQLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB78</accession>
    <name>A0A9Q0RB78_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA replication atp-dependent helicase/nuclease DNA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_08403</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="306218at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="15">
        <location>
            <begin position="42"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="16">
        <location>
            <begin position="1082"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="16">
        <location>
            <begin position="1195"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="17">
        <location>
            <begin position="1272"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="707"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="797"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="902"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="976"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1531"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="804"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="977"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5073839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1821" mass="210070" checksum="A1361089BDEDFE80" modified="2023-09-13" version="1">MNKQIKNKPNYVQIKNQEKYMIKSIIKNKTNRYFVLRHATEGTLSVVVPKGKWRNSILNVGNYVRIFISPENCDYKQKEYFCLTNTDIMIVEPDVLVNVTTVHQSEWCLRKVVLSQKFPRSYNELTEATLLVGNILHLIFQKFLQFALISCDHSLLEKIVREVILENWESMLLSPTTQVNQLISEIFKSIPHFLDWRKSFFIDSSEILFESDRLVRFKCLNLLSSEESVWSPLLGLKGRLDAVIETLFFPNLSNQIQNSDQIQKNPFLSSEEKEQSQQQIAILPLELKNSTKMNASSHLAQVVLYLQLLKNRYLQDIPCGLLHYLPLKPQQSMLGVEHNQHVLVDLMIQRNKIVDSFKQNHLPDFDDPSRFKCQKCGFRKICGIFEQLDHDPFTQPQFDLTSSQELLSQNHVNFLKKWNRLINLEENELISTQQNIWIQKRSERESLGLTITRLSLIQDSVSTRFTWIYKFYRAPDPKMNSKGKKQESLLKMDHFSEGTRVIISEDFLEDEEFSKFYSNKIGICEGYIVALSRYTIEIEVHQRIFWLDKKNQQENQFWRLDCSEHTHSLSLARDNLFKLFSEPSNLGLREMVVDLNSPQFMNENKTNINNLFKNNQNQLILNQLQESSLKNQFQINSLLNSNPKPNLNLSNSLNNNNNQLETKYQEKSPQIKLIPLNFHNSNQNLNSNLNSNSNQNLNQKLNQNLNLNLNSNSNQNSNSNQNSNQNSNSNSNSNQNSNQNLNSNLNQNLNQNSNQNSKLNSNQNQNSNQNLNLNRFKSFSPLTIKINQNLNQNKNMLPLTPLKLNPLFNQNSNSNSNSNSNSNQKKFNPQPLTKLKLKPLLNLNQNQNQTLNLNSNPKPNSNSNQNLNLNLNLSNSKQNLNLNLSNSKPNLNLNLSNSKQNLNLNLSNSNPNSNQNQNLNLNLSNSKQNSNSKPNSNSKQNLNLNSNSKQINPLNQLETKYQEKSPQIKLIKLNFHNSNSNSNSNSNSNSNSNSNSNLNSNSNSNKNSNLYQNSNSNSNSNSNSNSNSNSNSNLYQNSNSNSNSNKNLKLYQKIDLELENLKKEQTLLNLSQKRIEKLSKFLNEDQLEAIKKVLLSQNYTLILGFPGTGKTTLISELIKILISNNKSVLLSAFTNIAVDNVLLKIKDFFQKHSTKFIRIGSSQRTHKEIYEFTLENMVKSMDPENIEESFVINFRENLEKIQLVATTTSGMNHNFFRTRKSHFDFCIIDEASQVSVPNTIGPLLYAEKFVLVGDQNQLPPLVINPIARAEGLSTSLFETLYVHHPESSVSLTTQYRMNQEIMSVANELFYNHKLRCPNSLISSAKLSLNFSSQILSTFFNPKIPLEILKAIDPDLPVLFIDTQKDSSFRETHDSGSLYNIKEAELTLGILNAFAISGLSGSDIGVISPYNAQVKILKHMIKSSKSQNLIKSQSSNSSPSLINSSNDLDGLEIHTIDSYQGRDKECLIITFVRSNDRKEIGTLIPDWRRINVALTRAKKKLIMIGDLNTLDNCDFISKLANLVRKNKWVFEITNLEPNLQENLNQIENLNQNQNQIQIENLNQIENLNQNQIQIENLNQNQNQIQNLNQIENLNQNQNQIQIENLNQNLNQNQNQNQNQIENLNQIENLNQNLYQNQIENLNQIENLNQNQNLNQNQNQIQIENLNQNQNLNQNENLNQIQNQIQNQNQNQNQIQIENLNQNQIQIEIENLNQIENLNQNQNQNQNQNQNLNQNQNLNQNQIENLNQNQIQIQIENLNQIENLNQIENLNQIENLNQIENQNKNQNEKEKNLLKNSETRKREQNFNSICTFYNEKRNKLSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB86</accession>
    <name>A0A9Q0RB86_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Presequence protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB86"/>
    <dbReference type="OMA" id="CVEGPFW"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="1">
        <location>
            <begin position="457"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1043" mass="120499" checksum="925DBC8AAE723889" modified="2023-09-13" version="1">MQTNHWEKIQEVSIEAGILLQKFQSKLTNIVVAIAQVEGPMVNGYVAIPTEAKDDDGCPHVLEHSIFLGSEEYPYKGLLDLVANRCFAEGTNAWTATDHTAYVYQTAGDQGFLQLLPVFIDHILFPLLQQEGFLTEVHHIDGEGKDSGVVYNEMQAIENTNSRLSYRTLKQKLFTDESGYSSETGGKVENLRKLQLEKVKQFHKQLYRPDNMEIIIIGKINPEDVFQKLYPIEMKIKKKNEDQKEKSNERPWSSPLPKLQESVDVTVKFPDDAEETGIVRIGFRGLKYNQFLKNHAIELLLDYLTETAISPLQSAMIEIEDPFCTEIAAGTFDYSETASMFTFEGVPKSKLYMIKDKFFEVINKIISEKNFDLDRMTALMTRQRLQYLDILESKPQSRIPYFFIFDFLYNDPKNADNFKQIFNVNERLKELEAKDKQFWLDLIKESFGEKHYVCVVGEPSKEKGKELQEAEKLRLEKQKQELGDQRIKELDEELKKAIETVSKEIPKEVINSFEIPDISRIGKIPITTQINDEKSLEINEDKEKAEKLYAHLGMQEDPHVPFFIQFDQITSSFVEYRVLLDSSKLPSNLRPFIELYLEVIFKTQIQQEGGELISHEQVVSKLEKDTISYSNSVGFEGSQNFSCGAFGQLVILQIKCESAKYRLGIEWIRDILWNTLFPIERLKVAATTLLNDVARNKRDGMKVAFSGIKSLLFDKEKSNHVATNMINQHKFLTQFMKDLEQNEKSAIDLFYQFRNQLCKLENLRIQVVGDILSLEKPKEPWNDIFVPSKIKEQKMEEKTENEKINQNQSFIAQLTQFKNSNQLKREKKEKIGAVIGLSSVESTFSVQAVNGLESFDHNDIPALSIAIKYLTTMEGIMWNKIRGLGLAYGYGIFSLVEQGFIYFYLYRAGDSVKAYLQTKEMIDDFLSKKIQFEKDEFDAAKTVVISSLIRRESKTSSRGLQSLMDLFRKIPRYNQLLLIKTQQVQIDDLYLVLEKYLKPLFDENSTDLILVTNPSNVQSIQQGFEKMNRKLELFEDVESFFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB91</accession>
    <name>A0A9Q0RB91_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras gtpase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB91"/>
    <dbReference type="OMA" id="INDXQIN"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="170" mass="19206" checksum="28B341129BD3ECF2" modified="2023-09-13" version="1">MGEHKYQVVIAGPGSVGKSAITLQFISQQFIRDYDPTIEECYKKHIFVDNEVAYLDILDTAGQEEYSSLRSHHFQNGDGFLLVYACDNRKSFEEIGEFRDEIIRAKDDDDVPIVLLANKCDLPKGDQQNVINIEESFAQCVREIRKRRAVDPSGPTAGQTGKKKKGCLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBB8</accession>
    <name>A0A9Q0RBB8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_08786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBB8"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5073378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="92" mass="10907" checksum="5B0CFBB7C91DBFB4" modified="2023-09-13" version="1">MTDQRQKKETKMMDQPINVIFRHLQSKARIQLMLYDQKDLRIEGYLIGFDEFMNLVLDDAEEISMKKQSRKSVGRIMLKGDNIICIIDTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBZ1</accession>
    <name>A0A9Q0RBZ1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Adenylosuccinate lyase</fullName>
            <shortName evidence="6">ASL</shortName>
            <ecNumber evidence="2 6">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01238</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="2 6"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBZ1"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="352"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5074607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="431" mass="49067" checksum="6C7C02B0C8B7E6A0" modified="2023-09-13" version="1">MDWISRYETPISEIFSAENKLKLQIEVELTILKALGEIGKIPKETYSVMKELIEKEPILLERVKEIESEIHHDIMAMVKAIAERSEKYGEYVHFGCTSQDINDTVQALQLVQAKNILLQSILDLKKTLKNLILENQDVVQIGRTHGQHAIPLTVGFKFANFLYEISVAENHLKRTTINIAKLGGAIGTFAALGTKDVQTIALKELGLEPAPISTQVLTRLHLVDFVFSLTTGSCVLERIAKEIRNLQRIEIDEFSEEFIPKQVGSSTMPQKRNPHKSERICGITRLVHAQLNPLIETIALEHERDLTNSVVERVSVSTSVILYHFQLLSLTQILSKLYVNKESIERNLHFLKGKQLAERLMIELTSKIGRQKAHELLRVLSFEKDFEKALREDETIKQIFSEEQIKELLIPETYIGLAKEISLEIAEKFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCE0</accession>
    <name>A0A9Q0RCE0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Guanine nucleotide-binding protein g(O) subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_07619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCE0"/>
    <dbReference type="OMA" id="NCFGESD"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF362">
        <property type="entry name" value="G PROTEIN ALPHA O SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5075266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="354" mass="40964" checksum="E88C9F2122FF37FF" modified="2023-09-13" version="1">MGSKLSRAKRLRKQEEKKNKEIEERLQKEKEIAAKEIKLLITGTGDSGKSTFVKQIQILFKEGFTDEDKKAYLNVIRFNLIAHTKMLINAARELNIPLLKENEDLADDFLESAGLSKTMVPPNVVQSIKRLWKDPALRIAYDRRSEFQLPDSASYFLDNIDRIIEPSYSPSEQDVLRSRIPTTGVKVLTFTLKDLPWRVVDVGGQRSERRKWIHQFDDVTVLIYVVALSEYDQKLYEDESINRMRESLALFDKTVNHPSFKKKNCILLFNKRDLFEEKISKVDLTVCWPEYDGGLNYNNATEFIKNKFLETGTIKSKKAQRQIITHFTCATDTDNIKNVFDSIQNTVVTSNNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCX9</accession>
    <name>A0A9Q0RCX9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCX9"/>
    <dbReference type="OMA" id="GQYWDAW"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10789">
        <property type="entry name" value="GH38N_AMII_ER_cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="7">
        <location>
            <begin position="560"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1132" mass="131551" checksum="E8EB9FBDE02F420D" modified="2023-09-13" version="1">MNFAKFPRDMKYRVPRAKKYLEFIQPKTRKYTITSNTIESAHNEPGAFKFPTNLSWNPTQIVAFGIHASSFHYFKSTLSVPNNWNISGLDNLEIVINITPNFQVENTWDDTFPAGPEGRVWVNEKLVGAYDNEHNRILLKNLFPSKTRKFDIVLAMFSGRVTALHTIPQFSLNYIDLQTQSLYRDLSVCIDLIEVLKDEDPSKQVLLNAIDAVVLNIDITEELNPLPVIYPKEYIRDPKQFVSQPREKSDILMQYLSQNLIDQTKPSVACIGHSHIDLAWLWPFSVTKHKIVNTFSTQLRLLHQNPNYIFLQSSAQAYKWVEQNIPEQFKEIKNMIKQNRWEVEGSSWVEFDSNIPNGESLSRQILFGKRYFRKKFGVDTKTLWLPDCFGFSASLPSILAAANIEYFITSKISWSEYNKFPYQTFNWVGLDGKSSVLSKFISTPSKWGFSTYNALMTIEEIDRIWKEFNHKNILQDMPLLTFGYGDGGGGPTQKMLDTAYRLSGNSFINNSQNQNEISPLNFLPLPNFPKVKMTKISDLMNSLSSIKQEFPVYDGELYLEYHRGTYTSQAWIKRFHRKFEISLHNLEFLCSLSSLFSTLNLVDNQFIYPKKEIDLLWEQLLLFEFHDVLPGTSVHETYDEIHQKIPSIKEKIHDIKSSALQFIFNLIDRKKFQNPLVLLNSLSWNRSDPILYNEIHSDLNLDNFEVPSFGWTVVENPFESINSNESLTSNDPNPFDLVYKEADFHLSINKPQNKSSVSKINDTYYLKNDFWILQINMNGEIISLFDQKNGRNVQADGQILNKFRLFQDRWDINLYYNEMELPGPKCISIEPIYENNACGVQVFWQFPQVKDHPDISKITQKIILYSTNPRIDFITDVSYYEHHKLLKVDFPVNIRSQTATFEIQFGHISRNTHWNTQFDIAKFETIGHKFVDLSEHGYGVSLINDCKYGYNIHSNIIQLTLIKSSTQPDLIADRLQHFFTYSLIPHKNSFQESRIIQAGYEMNYQIHVSKQYPLSGKINSSFSLLHCSSPSVIIETIKRAEDFENSFVLRVYESYGGHSFNSTIFVSDLFPLKQVKVINLIEDDILLEKDLKLLNFQFDSSKNSFSFDISPFQILTFLLDFEKSNKIEENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDA6</accession>
    <name>A0A9Q0RDA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDA6"/>
    <dbReference type="OMA" id="LAFMDVM"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="140" mass="15991" checksum="BE225005BE51A5D4" modified="2023-09-13" version="1">MENQKNCIFCKIIKGEIPSYKIYEDENTLAFLDIKPLSKGHVLVIPKKHVEYLNELDEETAKEVMGIIPKIASAVISQEGVEGWNLLSNNGKFSGQEIFHIHFHIIPRRNKDGLGYRWNTGDLDSDYAAEFVKNVSEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDY0</accession>
    <name>A0A9Q0RDY0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDY0"/>
    <dbReference type="OMA" id="GMTELGW"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="64"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="245" mass="28855" checksum="1AB1814B03FA7F4A" modified="2023-09-13" version="1">MDQLDNKKQEKVRQFISFTTATEETAIACLKRFHWSLERAVNDFFENPPPPQPVKKSPVTKRKTNREELEKLFRKYKKSGENKIDAQGVANFFNDLGVDMTDILTLIIAWKLRSKSFSCDSISAIKNKLPDLRKEINDKTKFTEFYSFIFDFGKEHPDHKFLKNEIASALWEVVLKGRFKFLDNWLEFLKKPQNVKQTINKDTWNLLPEFGETTNLDLSNYDESAAWPVLIDEFVEYLQELKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF99</accession>
    <name>A0A9Q0RF99_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF99"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="588" mass="68688" checksum="B9D80D446B4967AD" modified="2023-09-13" version="1">MNDCLFFGSNQYPKLIKNESDKITKPIQFKFENENENENEKQIKQISSGGFSTIFLFKNGKAIEYLRSSNQKPQKIQIEENIQKVTVGFSNEAILTIEGNVFAKGNYINSKNPNEFINISSLIEDTNDRIIKDIVSGAEQIYLLTSNQNAYGIGSNEYGQLGFDSKTLEKTEKPILMMKNVSKIFSGNCSYHFFLLNSNQELFGCGFNYNGQIGLGESRKKETMIKKLTKIQNIPKGKIIDIQCGHYNSLMLIEKENENPKRKLYSCGRYQYNGLGKDEENTYEFTEIKSSLFENDYNILDFSVGYFHNLILTSNSKLIGFGNNEHGQLGTGNTNNQRIPIQTELPKLRFNEDISNYHISCGNLYSSFLYYSPFLSPFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNEIEIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYYEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIDELERGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGH9</accession>
    <name>A0A9Q0RGH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGH9"/>
    <dbReference type="OMA" id="VWVIEIN"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="355" mass="42302" checksum="B532ABEDAD9A1B0B" modified="2023-09-13" version="1">MSLAEKLKKVQLKQTETKDSSKPDITAKEYDENEIKIYQNKVLDINIEEWLDLIPEFTFKTKLFPLKYEDAELFFQAYELKMKENKELTENIKNQIEKLAENLQKVINEIKQDDPQVFVKSSSRSAKDTGPYQQKFIMEYQAKLKAKKLRDDNDKMISLLEAGYEMLKVKSAKELLMNWVFSERIYQDMFIAIKHKSRFKENFVIRKWVDMDPDMEFRGFVSNGKLTALSQYNHLCFWPRLVQMKSYLEKIIVDYFYSNIQKKLESNFKNYIIDFCVVGEKLDQIWVIELNPFLSTTDGCLFSWENEKSLIENGPFEFRINSKIRSGGKSLMQTSWREIFEKYSNIDNEEDEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH07</accession>
    <name>A0A9Q0RH07_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gtp-binding protein rho4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000004">
        <property type="protein sequence ID" value="KAJ5080681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH07"/>
    <dbReference type="OMA" id="NIESKWV"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="198" mass="22375" checksum="AD7591500E788B20" modified="2023-09-13" version="1">MTTLAQNRFKLVCVGDGATGKTCMLITFIENKFPSGYVPTVFENYNAKFDVDGKPYEMSVWDTAGQEEYDSLRPLSYPNANIILICFAIDNHFSYENVVTKWAGEVRHYCSNAPVILVGTKTDLRTDPLAQEEMKKNNASFITPQMGQDLAKKINATKYLECSAKTRHNLKEIFEEAIRTITSKNDKPAVKKKKCILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHA6</accession>
    <name>A0A9Q0RHA6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHA6"/>
    <dbReference type="OMA" id="NIFGEYT"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="15"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="191" mass="21465" checksum="1EC4112D2DA2130F" modified="2023-09-13" version="1">MELQKNFPQFADSEIVQDIEYVKKLQEWINNNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKQNFIFGGFTQVGFKHSYGESINDSSAFIFSLRNDKGDRIPAKFTYKQGYAIYSSLGNGPTFGAGNGNDFYLNSSLQPGYSNFGCSYNLPNGITQGTNEAQSYLAGSYSSWVVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHG4</accession>
    <name>A0A9Q0RHG4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_14156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHG4"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040208755" description="Fibronectin type-III domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="169"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="342"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="553"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="654"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5080139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="801" mass="88415" checksum="CA6F78B64B77A1C0" modified="2023-09-13" version="1">MNLKKKLFIFFILLILFNEVITTKDKIAPKERKKEKQKEKEKEEDELIWNEIEQILSNDGSTRDLFSYSISISENRKYLVVGAPFASANGKADQGKVYVFENNGTNWIQTQILLPSDGDNDQYFGSSSSISRDGTFIVVGSPSATVSGYPSEGKAYIFENNAGNWIQTQMLFANDSESYEYFGSSIAISQNQTYLFIGAPFATVNGRTSQGKVYVFGNNAGNWVQTQILFTTDTGFYYQFGTSISISENENYLVIGAPGAAVNETSHQGKAYVFENNAGNWVQTQSLIASDGGLYYQFGTSISISENENDLFIGAPFATVNGSSSQGKVHVFRKNAGNWVESQPLIASDGGLYYHFGSSISVSQNDTFLVVGAPGANIGANNSQGKAYVFENNGTDWVQTQIIAESDGNPSDRFGFSVCALLNDIFVGATFASVGGNSSQGKIYVFAKFSAPSQVNLLNCSSLFSSFNCYWNQIPNDSSHIEYQIIYNSSWEVIKSPNLNQGTYYQLFNSSIYPTIIGNADYSIQIKACDKTKTPKVCGKSSNAWNLQTRIDSVTDFYLKALSENSIQVSWNYPNVPIIDSVPKLSHYVVSYKKQSSYQTSNISVLNSSTSYQITNLDTETLYSISVWGCRSEGCSGEDQGKITSGSISTLFGKVLNLQCSNLKDYHVSCSWNPPTIGTPSYYNLTYRATTQNDFNTINTNMLSQEFTVKFLNQEYQIDVSACDSFLQCGTVSSVKITTLNSNQSSQSSSKSTKIALGVVFSIIGVALIALGIFWFQRKKNRITKYEKLELEKGEIKANQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHK6</accession>
    <name>A0A9Q0RHK6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000021">
        <property type="protein sequence ID" value="KAJ5079918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHK6"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="3">
        <location>
            <begin position="284"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="397"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="717" mass="86739" checksum="CB68864FF3F7857B" modified="2023-09-13" version="1">MINQLINFKSSSIQNPQELITICFSFLFSYIQNENENKNENEREAKKKILLTYLQILMQENYNFLFGLFSSQNKKHSLLPRKSNNSFVFSCKNIDEFEEEIMKKKWEKAVKIVFFPINEKICKDIEENEKEFVRIQSNNISYLKKIFNQEYIITKKEISIISNKLEKQKQNIISKEKKRKLKTETNQKKELFSLQKFNKMIKNLILEKYPLSSNSIIILDKEFKNEQQNYYIKLSEIEDEMRRQKKLKFYSQKNENENKQNLIKLNQKIKTKINEIEEKLSQIQNDDNNSFTTKCEIISKTKITKGIFEITENSINFFNFDLKKEKEKSYSWKIENIEPIHKRRYLFNHSALEIFFENRKCTFFNFETMEKRNEIYEKIQNHKLTSIYQSKYNYSGNESTKWIEKTQITEQWQERKISNFEYIMYLNTISGRSYQDISQYPIFPWIISDYESEKLDLNNPEVFRDLSKPIGILNNKIITYSEKYQIKGKEQEFDFNYQTLYSNPEIVSSYLIRLEPFTSICLEEKYPIFKSIPETWKKIKESSNDFNTELIPEFFHLPDFLRKRKIFSNENEIENQIENEIENVELPKWAKTPEEFIQIHKEALESEYVSEHINEWIDLIFGYKQKGKEAKKSINLFHPNLYEENIDFSKFEKMKKSKKKFKEKDKFQYNYLQKSIQKDLQKKRSNKDLFHLLSHYLNGKISCYQIQLSILSEKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHT6</accession>
    <name>A0A9Q0RHT6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000007">
        <property type="protein sequence ID" value="KAJ5080577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHT6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="551" mass="63789" checksum="5841E3F3330C6057" modified="2023-09-13" version="1">MNDCLFFGRNYQPTLIRNKSYEIIRPIQFKFENENENENEKQIKQISSGSYSIIFLFKNGKAIEYLNENDLKQNPSKIQIEENIQKVTVGFQNEAILTIEGNVFAKGKDINPNNPKEFINISSLIEDTNDKIIEDIVSGHSSIYLLTSNQNAYGIGSNQNGQLGFDSETLNETQKPILIMKNVSKIFSGNTSNSIFLLNSNQELFGCGNNKFGQLGLGESRRKIKIQKLTQLQNIPKGKIIDIQCGSTHSIMLIENENQNQNPKRKLYSCGNYEYNGLGQHAEKSYEFTEIKLTLFENDYIIDFSVGNAHTLILTSHLKLIGFGGNLFGQLGTGKTNRSQLIPIQIELPKLRFNKDISSYHISCGYRNSFIYYSPFSFSNLEEDLIKLFERKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNKIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFRILDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHU8</accession>
    <name>A0A9Q0RHU8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHU8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="386"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="557"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="591"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="625"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="894" mass="104134" checksum="4E7E12A1901C8FC7" modified="2023-09-13" version="1">MSQNKNNKKKTKKQTISIEEIIEKQDIESLRKLKRIPKEQLENVGKPVLHFAIQKKVSKEMIEELIKKGANVKAKTNQNQSVLHYACQYRNSLDVFKLLVEKGADVNAKTTENQSVLQCACQYQAPLQVFKLLVEKGADIHIKNNYNHTILFYTCFYPSSLSVIKFLAEKGVDINAKNNYGLTAFQEAFYYKNKNMLKYVLLDDIDVDHLYKSQINKEFVESFSNVYSINQEMSNLLTSDEISGDFKIKCNDGSIINAHKLILLTRFNNDETILQKFVDNCYKKDNEVVKLVISFLYTGFVAFEEFTQKLKDVSKNYKEYTNLYDWLCNYGANGDEVMSPDFKEKEQKIEDFFKEIGLDSNWMKSKKGRKPLLKDLDQLYQNEETKDFTIICEENGKEKEIKTHKLILMIRSELFKGMFLSVNDSSNKVHDYSGKPFETINQLIYFIYHDNFDGTKITKENIEEYEYLKGFYQLNENSIIDLLLLDVYNNFNIHTDIEEIIEKQDIESLQKLQRIPEEQLKNVGKPILHFAIQKKVSEEMIEELIDKGVDVKAKTKENQSVLHYACQYQSPLQVFKLLVEEGADVNAKTNQKQSVLHYACQYRNSLDVFKLLVEKGADVNAKTTENQSVLQCACQYQAPLQVFKLLVEKGADIHIKNNYNHTILFYTCFYPSSLSVIKLLAEKGVDINAKNNYGLTAFQEAFYYKNKNMLKYVLLDDIDVDHLYKSQINKEFVESFSNVYSINQEMSNLLTSDEISGDFKIKCNDGSIINAHKLILLTRFNNDETILQKFVDNCHKKDNEVVKLVISFLYTGFVAFEEFTQKLRDVSKNYKGYTQLYDWLCDYGTNGDEVMSPDFKEKEQKIEDFFKEIGLDSNWMKSKRKKTIIERFRSIISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RIH8</accession>
    <name>A0A9Q0RIH8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sister chromatid cohesion protein dcc1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RIH8"/>
    <dbReference type="OMA" id="DSESWPF"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="396" mass="46666" checksum="C7947D3BB76F0D29" modified="2023-09-13" version="1">MNSKEKLNIFFSDNFDEKNDYLLLEISEDVLENLQKTQGKLYFKGNEDENIVLCSNDKTFEVKNAESTNSLFLIPHKIKNENNKLLVEESNLSQNDIHILDIDSIQIISKHNSNIELNQTSPKLHKLRELLNQNKYKGINKNGERIENTDANMYSFDDLLDNIQASKKEIEKYLLDLNAFEFHGKWQVLDTSFQNELLDMILSTIEENNWSLENVLYSDCVQALNLMENIKYEERIIQHGLESLSKTPRSLVSKNQDIYSLDSEKICQFRAKQLFQKQKKWVVDKFMDEWEEIVPFGISPNLSMLKKFIIYENMEDTESIDNTNLNSIRYIDLDQLSHIVEERFEQLFTIKKEWGGEEIQPFLDQIIGPNQTLESLLLKNSRKCKTLDQRIYYCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5I5</accession>
    <name>A0A9Q0L5I5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5I5"/>
    <dbReference type="OMA" id="QIQNNYH"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="352" mass="43793" checksum="720D32D0F027E719" modified="2023-09-13" version="1">MNSRKHLQNNKRNGEEQEQKQEQEQEEIKRKRKENKKEQKIKIKNEQERIIQKDANPKQNYYNYYKNQNNKNNNEIKNRIRIQNLIQIRIQNENQIRYQNENQIRYQNENENENENENENENENQNENENENENENENENENENENENENENENENENENENENENENENENENENENENENENENENKNENENENENENENENENENENENENQNENENENENENENENENENENENENGNENENENENQNENQIQNNYNQNQNNYHQNNYHQNNYLQNNYHQNNYHQNQIQNQNNYHQNNYHQNNQIQNNYHQNQIQNNYHQIQNQNNYHQNNYHQNQIQNQIQNNYHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5J5</accession>
    <name>A0A9Q0L5J5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tobamovirus multiplication protein 1-like isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_13372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5J5"/>
    <dbReference type="OrthoDB" id="19353at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="7">
        <location>
            <begin position="10"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="265" mass="31401" checksum="80A03A45C1688C0E" modified="2023-09-13" version="1">MVKAEFWVEISFYSVLFVFLFIQIIRLKIYREIQLFYNLQLKFHVLSIIFAIARIIVTFLENFLKARKLEIFIVKRIAYLSFFTSFTLLLFGLQHNDKTPNSVKIPLVITNIVFYLFTLISIFIFSTHIQEPDYSSKFYQVNSSIVAAAFFIVSISFMIYGIVLIRKFKKMFQTLLNRKRYLKKTTFLSLFISLCFLLKFAVFLCYPITQKKFNDMLFIFIGYVIPELIPAFIQSIIMGPKSQKVMEPIEMHLLETEIQHNNQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5R8</accession>
    <name>A0A9Q0L5R8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HYDIN/VesB/CFA65-like Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="KGGYHYR"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211:SF1">
        <property type="entry name" value="ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ASH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39211">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1357"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1448"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1375"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1448"/>
            <end position="1474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2996" mass="347390" checksum="246154DC851ECCFC" modified="2023-09-13" version="1">MTTKKQPNLIEIQVGEKKTKQFDKKIEIDFGEVTLNGKSELKSIKITNKEDFDLEISIKSEKNAVWFQSQNPNLQFKDSNKHNQIFNHVSLIERFELQGRQTKDIVLNLQVPEEVTKAKKAKMETKEGLVQEVNGNDHHHCMTFCTSAFFTATPKNPQAVNVFSSTQIELVTLVSGCRSSMSLELGGANEIFLDQCVVGHWSFREFTIRNKSSITLAFRFASTSLNSIGGVVEFSDFESGSIIEEGEIPGYSTKIIMLKYKPAQKGELEFEILVENLNDDRHSKILRVRTSTGKSGPTQRLILVNPRINFAACYTNTKNQKEINIQNISQEHIVIKLSSDLGKEVTFGIKEEEDPYTKNQDNGFGKNNQMGQSISTSTSHEDLERISNSDERSLSFFKNKKENSEHGNHEDDRENNLIEEISLMPGKGRTIVVWYKPKDDETQILEKRVELKSRKFNIFAKVHTYTNKEERLLGKSTIFCKAKICTSMIILPTSVVNFGDCNIGTTSYRKIPIVNISALPSNIEVRFASRILRVKMHNFTIQPNNSVELELSIAPTIPNPEYHKQITIRNSNNPQNEVILKVQSNNVDQNRITFHALFYNIKTNSEGNLIDFGHCFVNNQTIQKIELKNITDDDIVIQLDSSSPQEISFLQHLELPRESRIRKLLKQASKNREQMAEFLERRTEEMLMIAAKTNDLSTLTHIQRQGDIVHGEGLRKKSSISISREDSSDQEMDLLGHRQINKRKFSKALSSGNVMLLEKMPYISNSQSLSDMDTNSDKEETIERDTETETETDSDNKRNADTISLKDSHEFGKNDFFGNPKNDPKQNQAQEKNDEIKMLQELEKMDHKFMSVEEVFEEMAKHQQYETQIFANHKQELNFINKFISARRMMEFYTKFGILQDITGKEVRIPRYSRVEIFVLLNTKHELRPEIIGKWVKREENVLVKLLYFNKNLAQKLQEFRHLRTLSTDHMPVRKIPLRVRLCRSTMKIPQKNLNFSRLEKYENRTKSITLSNISDAPLMFRILKSGSISSSYLHFDEYLGLIKPFKRKEISFTFQSRIVGSYNEKVIVENVLDSANNQVVEFKAFIYRKPVFNVNPESIDFGPLLINARSHPHIISVVNSSKHSRLFKLDHETPSEFEAQEGLQIHVFYELVANNDDPTASIILTKEQLHNLEILEKQLKISIRKGYTNKMQEIQKKIDTIRFGAKKKKSLKLEKTPLKSQTQPQKPSISEESLVFSLRGETRQKISVSLAFQISPQAHKKSPSIQNTLKDRSIIINDFIRVYETNDLDIFKKISVSAVLCKTTTKYLSKQNKFLFNSDNYWLNVRLGTTSKVLVTELRNLVEMRNAHHENNIEKQRISPHSHSQSQPPPPPSLTQKNTKTFSNKTVYPEKSSDLKIDPAFLDLGQIDLNTTITCSFTFENLASRSIRFKVSHKSVSQNPNKFGNILMNPNLNQKQNVNQNSNTKKTPKNQQSRNKEIFDIKPKSGWASKDQKITVKFSFKINHYTPDSQVRRIFLNDLISNVSIPLIISYTIKQGNFLRIYHQKNTEKEVPDLIPFISDPESTFFKENFQLLVKKSEINDFQEIDFGVRYVDKQHEFTKPIPLFIESISSSPICVKISSNLPKQIHIFDDYELKHETKFIQLLPNQRKPVYFGLRPYISPELILKGRLRRIVGGIQIKIYSEIEDKTEIQGEYANENSKKNQDLDEQKVVIDKEILPEQEFKDENFRQKYPYLIHKHILPFSVFAGVSILHFKPKFIELGVTEKIGEKFRGQFQIINKSVLPTEWQLESSANIELEKTEGRVGKRGKETVKFCVESKNYGLYYESITLINKMALSQHKYMHLRLFVSDNSIEVRGLGRNEQNIEQLNFNQVYVTSTNKPHVFELSEHQIKKYHQFQIVNNKKIPICLRPKTNLNSLVIWEKYSKENRQKALSEFREQVLHSKISRDSPYSNIKLGGSLFLIPPQQTVDVFVTLPSKMSERKIHKLELGKTARFHGILLFEDVTTSQQRLTKMITLCGDYCFSLGKILTPKISLGKIGITSPNQGKPVEFSFFIQNQQEPDLHIKFEHIPPEMELVSQSPQITQQFSDFRITKISDLIIASKTKQRVVMLLYPEKISKEVRDYRQQIVIHNFTNPKNKMEIEVHATNMPQKKLLLQRLEQPGNILNVPKLKIPGELKGSKISEWFTLANNLDDENINVDVDFELSENAKKYFQCEILSRRSNVPVKTLVVEAKKEYELRVVISQKNQTTSTLSMIETAKGFIYGEIHISYGQHSKPERVVIKGDIDRKAMFKLRNSPVQFSYAHSDREQSDFFEIVNVSKDFPLKYKVLSKISSPNINSTTLRVEPHEGVILPIAKQTIHVFMSPNTQMPKPHEIEITVVDLSGREPEGKKVPIRVLQRSEVSENIDNENNHPIVKNIIQKNIIQNDNQKIIIQNQNKNNIIQNENQNNNIQNENQKLELKGCLTLNQNEERYLINIHHHPIKGLPTPSIIKRQIEITNPTHQTIEFQIRNFNPKDEECLIIKPNTKSIPKFSSTQIDFDILMDKVKTNCIHVVIENKTNIEDIKIIRFQIKVSPNESVHQESKNNENIENQQKSKVEEVDLLFGIISNGKYHQAGIEMAVLHLGNLYSGTLYNKYSFILKNPQNFPLEIELICDLNTKKKTELRFSLSPEVPKFTEIFSIAPRSQQQIYLHFIPYFEDSNKKEIWVSAKFGGNWKPHKILKLTMFVFEPTITISRNNVLFNLEKRAGHIWIVPEKALVTITKDAPKMKHPNDFSENQSHIWIRNESMHFICDTNQEEILFTPKIRHSDIVIKPREDLIKQSIANFRENHSWVIEEHIAIYTKENPSERYRIHIRLTGNNSLQLFLTSLESHRRFLLNMIEDKIIRFVKDFRNFIQKNNGNSVQNALFLNYFHIVDELVFFGLREWNGDSIQNLARLFFSSVFDQFFLEKTQFYQNYTELFENFVIQLSYFLSHFPDQSIQLLDVPELEKYLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7D1</accession>
    <name>A0A9Q0L7D1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Claudin-like in caenorhabditis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7D1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="179" mass="20320" checksum="F7C9D64BA3F620A7" modified="2023-09-13" version="1">MFRLITLITLLACGVLSFLSWVMPYLFSHWYSGSNSYRISYGNFQSTCTGDPCSNPWIYQSMKLSDWKDQDKDVYNGLCANIAMTLIGFIIFVASLFLLFKKSGITHLVFVTGGIFVFIGIMVFVGKFQNSKTHDYWEHSHETNSDYHWSYSASTAFSIIVFIVSLPGAFFALKAKSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7I4</accession>
    <name>A0A9Q0L7I4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ptp/dsp-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7I4"/>
    <dbReference type="OMA" id="AFYCKAG"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="167"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="302" mass="35459" checksum="8A8879A3813678F5" modified="2023-09-13" version="1">MENQLKYRSITLEKVENFRELRFNEKIKPGMIYRSASLGNASEKDIKELKQRVKLIIDLRRSEEIAVEPGEHKIYQEFPFEEKKTEEEKEDQNETYFDVEKKSAIQMSIMTGDFFERALKKESRKEKLKVVGMKTFNFLSCGGCCGFYKMNVNGKIYQLVMGETIGTFYIKVVDFAQSELRHVLMHYTRKENYPILVHCSLGKDRTGVIVALLLAILGLSIDVIAEDYSKTRQLLSKETVDMIKKHCEIKKINFEDIISSDESFIRNMFKHIDEKYKSLDNYFDTIGITKKYRDQIREILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8D7</accession>
    <name>A0A9Q0L8D7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8D7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="481"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="598" mass="69846" checksum="8A701C5C25F6CEFD" modified="2023-09-13" version="1">MNEIIFFGYNHYPKLIKNELNSIKKPIQFKFENENENEKQIKQISSSNFSTIFLFKNGKAIEYLKQNDPNQNPQKIQIEENIQKVTVGFQNEAILTKEGNVFAKGININPNNPKEFINISSLIEDINDRIIEDIVSGHSSIYLLTSNQNAYGIGSNKSGQLGFDSETLKKTEKPILMMKNISKIFSGNSSYSVILNSNQELFGCGYNKFGQLGLGKSRKEDVYIHKLTKIQNIPKGKIIDIQCGVFHSIMLIENEKENPKRKLYSCGDYSYNGLDKNQNTYEFTEIKSSLFENDNIIDLSVGNKHTLILTSNSKLIGFANNDYGQLGIEDRKYHYIPFQIELPKLRFNEDVSNYHISCGENNSFLYYSPFLSSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNENQIEKLQEIISNKSIKESNQIFEMIYSNKIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNQIKDEIEITQEIIDEIQIGIDYFQLNQTNPNLFDLLIKKFNNQNPKEKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Q7</accession>
    <name>A0A9Q0L8Q7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clustered mitochondria protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8Q7"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="3">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="729" mass="85169" checksum="C98E25012C6FEFFF" modified="2023-09-13" version="1">MEQLKQNETNIEKYNEIMDLIGNFLQTATYCAQTIIDEYPLKKSDKTFKPLFKSKENHQLKKQFHQQEHFEDDQFQEIQYESSGLTFKFYHKYKPELENEELSMKMANHLIQNGKFIQEANILGIQIPLQCIVDYKGFRMHISAKLPQDKEPVKLKDIQNLQLKQKIDLLLRKYGIAMNDEIMESIQVIELSGNENYLLNVEKFFPNEKSKSKSKSIEIKNLKENVVNRIRPELLVDIIKNNTNQNENDDISQIASDYLFSNTLPNFILQTDDLKIIPLDSEELKKEMHKNGINMRHLGVLANLTKIPHVRQLFMIDMIARICKKILFQQLRKTSKRIKNIESKEFPNLEVTEFDKKIMDSKEETETISNQKQIVFQTPNKSIKKNLFSEFNTPQNQKTINRINDNVSTVVIDFFNLVLGSSEECEMYWNSVLIPSVEKKFGFKIEYFLVHKPALFLSMQYHTGVEFLDSDEYDFTKELPVEKQDFIAIHPKPKIFYNENIFDGKIPSNLNEHNQMIQNLNFKLSVQKSIYGIENMEVSRILTKLSNLHFEQKDYSNSILCANAALGASRKFHGFISLTYLILMKAKYQVGDTKSAIECFKYSLDAIRFHLTEYHPLLIDAYNEIAHLYQRENNIQYALKFYTKALELSKKVIGIAHSKTAWCFFYVGGCYIKTNNFQDALSNLESGLAVIDSLFGKQNFSASIFHFIISEILVSKRRSFKKQKSTMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA03</accession>
    <name>A0A9Q0LA03_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA03"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="490"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="640" mass="74691" checksum="CF6EC8D2B5F0FF47" modified="2023-09-13" version="1">MNPNQNFILFFGQNEYQKLLKNELEEITKPIQFKFENENENENEKQIKKVSSSQNSINILFENGKAIEYLTENDLNQNPEKIQIENIQKLVSGRSIKAILKSEGNVLAKGYDINSNNPNQFINISSLIEDTNDRIIQDIVSGADSIYLLTSNHNAYGIGLNEDGQLGFDSKRSGEKKPILMMKNVSKIFSGSYSKSVFILNSNQELFGSGNNFSGKLGLGESRKKETQIKKLTKIQNIPKGKIIDIQSGGFHSIMLIEKEDQNQNPKRKLYSCGHSNYNGKDETTCEFTEIKSSLFENDDNILDFSVGYFHVLIITSKPKLIGFGSNFYGQLGPKDTPTVFKKTPTLIELPELRFNEDIFNYHVLCGYQNSFLYYSPPLFSNLEEDLIKLFGRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISTKSIKESNQIFEMIYSNNSKINSKLYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITNDIIEEIEIGIDYFQLNQTNPNLFDLLIRKFTKEGKKLRRKKYEERKLEKEKEKEKEKEKEKEKEKEKEKEKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA53</accession>
    <name>A0A9Q0LA53_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA53"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="43943" checksum="BFFE9348D89E882B" modified="2023-09-13" version="1">MKSRLKNEKFEREIFLKIFEQKSKKANQKVFNLKKTQKQKKKTNQFNAFIKIDLWNAFKTGKPIKFDHSFLHTKKSSLSKISSKIILPPFHELPQIEKHFNQDSTQEFFQFYEKGLVLINLQTGKIENRQNLIKFDQVDEKTKKKGKKEPKEKKPKKERIRNPKTPKTPKTPKNPKNPKTPKNPKTPKTPKTPKTPKNPRNPKNPKKSTTDKKIIFLQPNIKFGLKALSNFWKSLKERSKIPRDPKIKAKMINESTNKPRIFENKQRKKKRFAMQDDQIKHFDQLIWRDEEIILFHEFVLAFGRNWDQVAILLGGSKSTTQVKNLYYQKRKELFSSALGLVKSENEEKGKSKSKPKPNQNQNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB56</accession>
    <name>A0A9Q0LB56_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19599at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="1719"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="2055"/>
            <end position="2234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1203"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2837"/>
            <end position="2856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2163"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2703"/>
            <end position="2734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2988" mass="359927" checksum="66A6CB3B45B1A35A" modified="2023-09-13" version="1">MHLFQFSCSQNASYQIKNQEPKPITSQIIFESTKKDGFLIISSLLDFKDDFELLDFLEILNALKQNEFENIILNDLNKKKIILKKNPELLARLLFILKPSKKVKKIMDNISKCEANDFIKTNYLIFSAYYKTNKKELFESLKEFLQLFNKYSNRKSYKINFLPLFILFEQEFEFPKTTKKINDNIRNAIENVFSFYLQKEMNSYFKKEVLENIFGTKFDLSNPLWNNFMNSRFFSKSINKLIDFPEFKEKLKAENFKTVLDIFKFLLKMNEIAEQLTIQANQSKNLPIFDFNQKINIDDYLFKHPTLIDDNPNHISKISTITDIFKDKIYIDYIKKVDKKNLLKYKFIIDFEEQFQEIYMEDAKYEFKNIINNQTYLRFIPLNIHIHCWIKYVDFNQNQNQNQNQNQLLNWNDIIQKNEINSNKWRNVLLWFLTFKKSSPPLIKLIKDTKRINQNFEKQLNNYEKELNEYFKKLQDYPNTKIEDWKIFFRNEEIFTKFIKLKISNENEQNKIIEENRKKYIDLDEKISKIKYFFDQFKEKEKEKEKEGFKFDGLPKNFDKDSTLKDMENYLKKTEKKTETKTEKKTETTKSINLFLKNSFYKQKFIKYLKNLKKEKEQEKIKIEEICKTINEEWEKWKKETFNLEISFQKLKTESQINDEKRFKDEIESFGISEDLQIKINIFFELQRLIETINPFIEFCKIFLQENELNEINEIKEFTKKKENEIKLKDVENIKKEIIDKIKFDLSFLEFIKQLIQKNENKNENKNKSIIEWLKEKIQNKEFEEIIKKLNRNDDVIQKMRNSLIQLKDLFSDLFSKKFKNFKHFIKELEKIQELKSKKEKEEKEEIDIKLLYQSLFYIEEKNEEKDKEEDLPQKIENTFKQSQIIFNITKPLFQLNITNHKNENYESCLNMFRFILNQKQKQKAEMDENQNQNQKENRYIVEYQKLFESIEDIYNKMKKFSNIKSLYNLGKKSIDITNDPKSYKDKIKNFREELSEILGNWKIHKKEIKRINLSGFLSIHQLIYFYQFLKNKGDNFQLTESQIIIYQRNEKMFLSVLQLIFGKKEIIQEFIQNLENADITQFYKEFFEIIDKHYSLYSSIQLTLDYDDYFTSQQQNFRKQLIEKIDEKKTGGIHDSKIFITIMDNEEEEKQILNRILLIYHLYSNKFPLRKEILICDSKTTSNDITSFFSIYKYYNEKEKENINENENKKEKENKKANKNENQKENQKENENKETKFLFSITQTKFLSLKNIIHLISQIDSIDYITKFPMIIFDSISSDNLLQNRLKRDKLYINFQDKSISDIKPILSSIMKNNRYYKQIHVFFSKNQGDGKSFQIKQFCYSKIQQDYYHYYQLIQLHKGTVSELIKLLNQNDEKINKLKNEKRVIHIEFPSKCSNNITKALWGLIMWGSIEDQNPNSKNCELTECSYKKDEVSFKKYEFDKDKFKLKEDDDDDLKKVANCLIKIDNNTFFLKKTNFKTFQNPFFPNLQRDEKKEFIDISKKMLKEVSENIDSNSKNGITISYKLLSEFWFSMKMFINPILNWELIKTKLDNQNNKDNQDNNDELDNLQKLIKYWIFSIARFTIIPYLSTKKPEIFQNLYGFIFKLKTEENTKRIDVSQNPNEQFKNGIAFFYEQYNLSKEEQQIIEDLSKKYKFENKSWNNLEHDEKIKKFFKYISFLRENEVDPKLIQEHINNESKYVLTTDNISKMILIQFRTFIGIPTIISGETGCGKTALINYLFEDILNYKLITIHVNGGTTKKDIEESIEKAKNYISENVILFFDELNTAPENCISIFKHLFIDKTFEGKKIEDKIKLIAAINPYREQNYDDDPIGEFGLNVNDYENDDQNQKFFKQNRNLAYRVHEISESLKSCVIDFHSLQSEKEEKYIEKMVENSLENQDKNRYKNKITKYISKSQKFIRTNQNQNSNQNQNSNQNQNQNQNQNQISNLQKNLNASVSLRDVSRFLRIFHWIFYEEKIKNLFVGYIVRQQNKKQDEYYKEIFEKKKKVRKQKEILEKIQDKFINSLDYDFEEKMIAKNTAIKENCLLLFICIYTNIPIFIIGKPGTSKTLSVEIILKSFELKYKENKLIEKLRIRSLKESLLQCSKLTTSEAIKDIFKNAKENTTNKKLGVVILEEVALADLNKKNPLKVLHSKLEKSEKILYKLKKNQNENENEIQNQNENENENENEIQIQIQNQNQNQVSVVSISNWVLDLSNMNRGIFLRRDSETDLENTAFQILSSSSSSKTSQNFIQIPKEFSNQLTKVYKDIINISQNNQKNRTYFGLRDFYYFLKMIRYSNQNNILYYNDSGLIANSLLRNFSSKPNIISNFDKLNELNKLNVSTYLNINNKTLISQNLKRKIFESYGFKETTVNFHFSRFIMILIENICNIPFILQEIEMINEQDYNILFGSSLYKDQKSIRIVKDLNKIQNYVREGKTVILINNENLYPSLYDLLNLNFRKEGNDYYTQISFGNITSNIKVHPNFKCISIIEKEYAYEKETPTILNRFEKYLVKPKEFIEKTSEHFYKEQKDIIENICRLTKIRENDLFPCYNDDLLYSLTLKYQYAIKKQFKDENEKEMKQFKQQFKKQWIRICKLEKILFIELFIKNKGENLQRTDKDLLIEICKEYMNEYCKDLNSLIQKFILPKDKDSKVQRSIVLTSESDLLKSKEKLEIENFNVEELEFTDYESDKEFKKKIKDIILHNKNENEKKKEEKKEEKKEEKKEEKNLIIIHFTPKILSQIIFHQFKYIIDSLFKTKNEKTKKKEMKNEEMKKQIENYYFLFLVHLSSTEETNTDFSFLFENNWEYYYIDNIYEPYFKLSILLNLQKEQKQKEEQKQEQEQKQKEEQKQKEQEKDLLQIDIKNNWEKIIESILQSSLLSFMKHDQIENAINFIKNEKKDGTILYKKLQNMIEKGKEKGINLYEWDRNKLIQQKHSSSKQNFESFNSFIQLEFRRKVKSILSIFFSQIMVNDNFKIKLNTNEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBM3</accession>
    <name>A0A9Q0LBM3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBM3"/>
    <dbReference type="OMA" id="FECKWNK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="483" mass="58016" checksum="CD1FACADD6718CD5" modified="2023-09-13" version="1">MKLMEHFVNLKDLQDVIANQENQENQNENEIQNQNQIQNQNQIENENENQNENQIQNENQIQNENENENQNQNENQNENQNENENENENQNNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNENQNQNQNEIEIENQNQNQNQNQNEIENKNENENENENQIQNQNQIENENQIQNENQIQNENQIQNENENQIQNQNEIKKIQRNSKNHKNHKNHKNHKNHTKKSKTSQKKNHKSKNKSKIISKNKSKNKNKRKEHSEKSSSNLSSQTNINNQNNNGNEKTHENNEEHDKKDLDPSQNEEMKIETKEIEIENPYQSPNPYQSPNKYDNTNQIEYGSPNQIENENQIENENQIEKENQIENQNQNQIENQIENQIENQNQNQIENQIENQNLNQIENQNQNQNQIENQIENQNQNQNQNQIKKEKKSKSKSKGKSKENKKEKSKSHKKHNHKQKHNHKRKKKTYKQEKSPKIHNNHKKLLKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC11</accession>
    <name>A0A9Q0LC11_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho gtpase-activating protein 68f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC11"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="149" mass="17546" checksum="189886E1A6BCD66A" modified="2023-09-13" version="1">MTTYNIAAVFAPNLWSKNRNDLSVGNAFPIQQMLVNYEQIFNKQSLINSVNFLDNQEIQIRQNNSEKDEIKERLNKRKKKGYNIDVLLDSEQKKALAKTLKILNNKSDNTKNKQRSNYNIQKYLKILIPFIILIIFLILFKLLTKKNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC69</accession>
    <name>A0A9Q0LC69_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell growth-regulating nucleolar protein lyar</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC69"/>
    <dbReference type="OrthoDB" id="10677189at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="435" mass="52283" checksum="11AA19ECC8B993B2" modified="2023-09-13" version="1">MSFSIKSASVYQIYQLLEFLDLFKSEKQKEKEKEKEKENEKEKEKQKQNEKEKEKEKEKEMEKEINEKEIVFWNVFKANKFEMDFINSSFNTIQQTLSQINPQIQIIFNENEKVLNIQKMNGNNSNYINIKEYNELISILEDQINKKGLFDYMSLAKDFLDEIKKYCLKKFPFISKEEIEPIYIKENVGFQEEWSTFFDLSFESGDDYGNCISCPNPNNFNKRLLDACYDARLIGYGRVYADYFESIFTHIPHEFVHCIQSKKKQLDYSERSWITEHDASILGTSFFYHIVKNMNQKTFHKFFPIEGLIEQFILYEFNHTIELKEKYSNENIQKLYLNWIDDYGLNYPEEDDPNINEETNYYMKQRVSIEGFFYSEDLFNTCFDYCLKDRTGDLKKLKKIIPNQIKIDQQKTSISKLSKPLKEELILKFIERIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCG5</accession>
    <name>A0A9Q0LCG5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCG5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="449"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="556" mass="64742" checksum="F388A305FB44B7F3" modified="2023-09-13" version="1">MNDCLFFGQNQYPILIKNETNKIITKTIKFKFENENENENEKQIKQISSSNFGTIFLFENGKAIEYLNENDSNQNPSKIQIKNIQKVTVGYNNEAILTIEGNVFAKGKDINPKNTNEFINISSLIEDTNDRIIEDIVSGNNLIYLLTSNQNAYGIGSNEYGQLGFDSETLKKTEKPILMMKNVSKIFSGNSSKHVFLLNSNQELFGCGDNISGQLGLGESREEETKIQKLTKIQNIPKGDKYTNEFTEIKSSLFENDDNILEISVGNAHTLILTSNSKLIGFGDNGYGQLGTEDTSWYQLIPFQIELPKLRFNENIYNYHISCGVSKSFLYYSPSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNENEIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYFEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEMIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCH0</accession>
    <name>A0A9Q0LCH0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCH0"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="143"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="344" mass="38052" checksum="399C4D215AE53AF6" modified="2023-09-13" version="1">MEDIKDRITEAKARIKELKESIRQKSQELNDTTLIHAAANVKEFDPSILGVRRELKGHLAKIYAMHWSEDNTHLVSAGQDGRLFVWNAYTNNKIHVIALRSHWVMGCGYSPSGNLIASGGLDNLCTIYNVRSEDPQLKPLCELSAHTGYVSSCRFLNDNQILTSSGDMSCILWDIETSTKITEFADHNGDVMSISLQKDNNMFVSGGAEGVAKLWDIKSGNSVATFEGHQADINSVKFFPDGQAFATGSDDATCRIFDIRSGRELIQLTNDDILCGIGAVDFSLSGRILFGGYDNNHCYGWDTLKGHQVFDLKSHTEKVSCLGVSKDGFALCTGSWDRELKIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE34</accession>
    <name>A0A9Q0LE34_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_11062</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE34"/>
    <dbReference type="OMA" id="PNNQIKF"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="640"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="458"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5070215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="946" mass="112271" checksum="CD2BC4487C1D987C" modified="2023-09-13" version="1">MSKKYFQEMNQEINQENLKKKNKINQNLIENKFPKFSKKNINPFDNKNKKVFSQKIKKTIINQENNLDKKQNLEENQIKNKFEPQNKTTFSRLCRIYQPRFKVKINQNKLNPNNQNKFNKNNQINQIKFNPNNQIKSNKNNQNNQNKLNKNNQIKLNQNNQNKFNPNNQFNQNPNNQNKFNKNNQNKFNKNNQNKFNPNNQNKLNPNNRNKLNPNNQIKFNPNNQIKLNKNNQNKLNPNNQIKLNKNNQNKLNKNNQNELNPNNQIKLNKNNQNKNKNQIKLNKNNQNNQNKFNPNNQIKFNKNNQNELNKNNQNNQNKLNKNNQNKLNKNNQIKLNKNNQIKFNKNNQIKLNKNNQNNQNKFNPNNQIKFNKNNQNELNKNNQIKLNPNNQIKSNKNNQIKFNKNNQIKLNKNNQIKFNPNNQIKFNKNNQIKLNPNNQIKLNKNNQNKLNKNNQIKLNKNNQNKFNPNNQIKLNKNNQNKFNKNNQNKFNPNNQFNQNPNNQNKLNKNNRNKLNKNNQIKFNKNNPCIVAHKINLIIPSKKENNQNQNQNQNQNQNLNQNQNQNQIQIQTKFRKPILTSKQKPNIKILNQLTEFEKHEIIQYCKVYFLGNKLMKMENNFNDSKGFYKCIIGDHIFYRYEILKILGRGAFGQVILCKDHKIYNSQVAIKIIRNRKKLYNQGKIEIEILKYIKSCGKGSNKNIVEIYHSFNFRGHLCIVFELLGPNLFDIIKQNHFRGLNIQFVKEVANQLLKSMNILSKEKIIHCDIKPENVLIKNVKKNNEIKLIDFGSSCFENNTIYTYIQSRFYRSPEVILGMKYGLPIDIWSLGCLLVELFTGLPLFPGESEQEQLLLIMQVIGVPSKEFIQKGTRSKYFFNDDYSPIIFPNSRGLLHKPSSKKLCSILHLPSDSLFLHFVSSCLEWEPEKRITPENALKHIWFKFHEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE53</accession>
    <name>A0A9Q0LE53_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pleckstrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_10479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE53"/>
    <dbReference type="OrthoDB" id="70570at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051765">
        <property type="entry name" value="PH_domain-containing_F"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280:SF3">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="43"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="163"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="378" mass="44620" checksum="58FB304201484300" modified="2023-09-13" version="1">MKKNTPQKNSTEIYKSKDQSIIETEKINRIIKKLRNPKKIERKLINHGPVMKISRKKKEKRYLILCSDIFIVAGFGKISKKRLVVHWIFNLETINVYDTPENNSDIPNSFSIKTPCKSFVVLTPNQEDKMKWITKLNKQIKKIKQELNIPDFEKQEAPIWLPDELVKQCYICKQKFTFVRRRHHCRNCGKIVCGNCSSHKMLLPNISEKSKRVCDNCYQEGLKKKAFEERFKNLTENSPNLKSENEKLRRRATIFVPVFETNKTLIEKPQNQPKIESKFSQRSKSKTLDNLEIKEINSNSNSRSQKNPKSPRFTIYQSPRLNIPLSPRFQKQNQKQNQNQNQKQNQNQKQKQKQNQNQNQKQNSPKNIFSSSFPRNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE84</accession>
    <name>A0A9Q0LE84_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase fhke-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE84"/>
    <dbReference type="OMA" id="HCTISRE"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="134"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="273" mass="31189" checksum="AA7A4CE0D376D220" modified="2023-09-13" version="1">MEEQKVDAWGKLVSLVQELPDIELIGEEMVTFGSSDKCTYVIKNQSISKFHCSFQLKKGQNSSAKIKDYSIHGTFVNGKRIGKGFSRPLFHTDEISFASIRDKSKPRPVACYILKLFSVLPREKSDESEIKKIYKIGRLLGTGKFAEVRMATDKQGKRYAMKIVDKQKFQEGETDDQQAQRDPAMDEMNILTKISHENIVGIHQVFNTENHIYLVLDLCTGGELLDKITAKGFYKENDAIVVMKQLFSALAYLHKMQFAHRDLKVFKLLEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE96</accession>
    <name>A0A9Q0LE96_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE96"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="312"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="542"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="645" mass="77346" checksum="8F60F0B82C77DDE3" modified="2023-09-13" version="1">MKQTEISQEFILKCKKGAIKEIQNLIPKEINVNSKNSLNETPLHLIFKYKKNEENLFEITKYLIENGADVNSKTIFDKQSILHYLFRFQKHQNLLEITKYLVEKGADINSKDKSNETALNFAFKYYIQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNKNQNKNQNQNQIQNQNQNQNQNQNQYQNQNQNQNQNQNQNQIQNQIQNQNQIQKNSLEIIKYLIEKGADVNTKDKYHETPLYYICHFHNPKIAIEITKYLIEKGADINSKNHQNKTPLHYVCQFQENKQKAFQIAKYFIKNGSNINSKDKNEETPFHYAIQKRNTKLIKYLLMNGANIFDLPMNIFKSNQMILSNFKFIKQFLLLRFDNNETILQKFINICSQKSKEYVQIALNFLYTGFIDFDNFMKIFHNLFDYCNQFQENEDNLQEDIVTWFTYHQENNKINNLFEKEIEKGFGIFQKENEIILTLFKEIGIDSNWIELKKGRKGIIKDLSKLYKENETKDFTIIFDNEKEIKVHKLILIIRSELFKGMFLNVQDKSNQVHDYSGKSFQTIHQFIYFIYHDKFSKNIKKEKEIILEEYFDLKDYYQLNQNSIIDLLLKEKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEA8</accession>
    <name>A0A9Q0LEA8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEA8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="147" mass="17961" checksum="90AD4F70DEEA4F62" modified="2023-09-13" version="1">MIYSNRIINPILYFEIKEIINLNEKIEETIKRIYLNKNENIKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSEESFQIFEYWIYSNQIKDEIEITQEIINEIKKGIDYFQLNQTYPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEG8</accession>
    <name>A0A9Q0LEG8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEG8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="87" mass="9996" checksum="35CA8DF4CF06E43C" modified="2023-09-13" version="1">MMMGQQPMMGQQPMMMGQQPMMGQQPMMMGQQPMMMPQQPMMQPTVHTEVHHKDHKKDKKHKKKDKKEKKKKGGFLKSALKALGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEH5</accession>
    <name>A0A9Q0LEH5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEH5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040188327" evidence="1">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="113" mass="13227" checksum="545D679C6497B654" modified="2023-09-13" version="1">MNYSILLFSFLFFFCFSQSEKQFNISKYEDFLFKGSWIKSNSNSEINIYLTRETGNAFLHFNNSNFTAEPFIVRGYLTLEDGTYLDDPKHFLFFVGEYDTITKKIHGPALSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LES9</accession>
    <name>A0A9Q0LES9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="3 8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="3 8"/>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LES9"/>
    <dbReference type="OMA" id="CVHMNDS"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="68"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="439" mass="49236" checksum="EDAC6ECABC47D5BD" modified="2023-09-13" version="1">MSTNQLQKIYKGTIIDSSKNGTFRLLKGILGISTEGKILFREKEEELGNITAKYNVQKEQIDDLERNFLIPGFVDTHIHGPQYKFMGTGLDLPLLKWLEKYTFPTESKFSNEDLAKNVYGKVIDQTLKNGTTTACYFATIHLTASKIFSDLVIQKGQRALIGKVSMDRNSPDFYVEKTQDSLDQNEEFIKYVKEKKNDLVEPIVTPRFVPTCSPQMMKGLGELAAKYNIAIQSHISENVNEVEWVKSLHPDEDGYAAVYDKYGLLNNRTIMAHGIYLTDKEIELFKQRNAAVAHCPNSNFSLSSGVLHLKKLLRNGIKVGFGTDVSGGYSPSMMDCIRQAIIASKATMFNTKNPDDELSYQDAFYFATLGGASALGLDSKTGNFDVGKDFDACIVSPFVSSANFHVFDDDDDIEIFQKFLFSGDDRNILKVFVKGRQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LET5</accession>
    <name>A0A9Q0LET5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sesquipedalian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LET5"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="8"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="240" mass="28496" checksum="B6464B3A7ADB4AC4" modified="2023-09-13" version="1">MSGIDDKEIYCEGWGVKEGHFVKSWQRRFFVLRGYTVLYFSNKPVHATSGNIVGTPKGSFNVYKANIKIIKNKKKKKKANCLKIKLIKGVKYYIAFPSEDEVESWRYIIKRVSKGEKPPKVNEINEHKKQRKMMKHPQMNQPQMMNQQTYQQQQMMYQQPQMMYSNPNQMMYSNPNPNQMMYSNQNQNQMMYSNPNQNQMMYSNQNQMMFQNQNPKSKSNSKSNDVSKIQIKIQIQLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF99</accession>
    <name>A0A9Q0LF99_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Wd repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_11204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF99"/>
    <dbReference type="OMA" id="ECGGWRR"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="263"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5070175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1269" mass="147353" checksum="191D794CE01AC40E" modified="2023-09-13" version="1">MAFIGHITALRYSIVNPDLIFCGSGPYLIAFNTKTSNEICRIKLTTNLRIHGIKLGNKDSNIFVFGQRKAFYVGFNIKDGSFKVISKYEMCTDWILDIISLNQVDSLVAFGFSHNYIELWDFSCEKLIISLKGTENCLLYSLAFFQNGNFDDLFVASGTVFGHIIIWKIGFLEEVFKGYQNQNENQNQIQIENENENQNQNQNQIQYQIQYQIQNQIQIQNQNQIQIIKELFRITEHDGTQFQMIEHQNRTVKHFLFDFNSNQNENQNQIENQNENEIEIENQNQIENQIENQNKIEIENQIEIQNEIEIENQNQIENENQIENQNKIEIQNENQNQNENQNQIENQIENEIQIENKIENQIENQNKIENENKIENKIENQIEIQNEIEIENQNIVQNQYKMIFQAYGHYSRIWDCKTLHDSVVSCGEDSTCIVWDFQGKQQKIFRGHAGKNIWCIDVNYDETELASGGQDGSIKLWSLLENKSLKLSSFQIPNYKTVKEIEVKEKPKKKRMKKKKKLKENENEKIEENGNNMDVDNLITKIVQKAFYDNLRSIKLISLDSVVFGTSEGNIYFLDYTTGIFNHIHKNEGEKNGIRQIQTSPSKEYAVALDFNDNALIVSIKDHKFIYQWQVNKAWKVFWLQEEIVVITTFDGEIYFWNVKEILKEAKEKKVELWKTFQINSKKMIFSAIMSEDGNFFICGDARGAVFCFGIGIAEFENSDQFSIRTHGRSVINKIRRFGKYYYSLGSDGKIGKYEIQKNQEQKSNGNKIGYDFVRLSVAKMPESLERLVGMFVSPNQEQQIIVALLQDDVVVWDLSQNTEIFRCYYGGGFRPMDYKATPDLSQMTLTFSSRGNIQVLYRYPFMYRSLGTSFHEEECFGSIFLTVPNWKRKKLFENARSDLERKQIEYTLQNTIFFCTGSLVKTIKIWKFEKETNKLTCIQTLEDHSSSIKTFALISNEEEDCWLLFSAGGLDKIICWEVLLTTNMNRLELFVQPLSTLVSFDKDVNDYRNRINGLAVFKHKSITNANTNNSENAVSSNQYFIVAGYSDSSIKTFIFDRKKKSFSLVEVLKDYHFGPILSITQTLINSNQNLDQRKIPIIWTSSTDGSVICWNCENHLHIQPIQIQRKRHSCGANCVSVANFSNKNFLSQFRFSQNYRILVSGGDDQSICVDLISIIDGKSVELIDSQVIWNVHSAGIRGIQVINDRIFSSGNDMRLNQWFIDFDKELKLNFSDQTKFVDIPSINNLVVNSDNSFVLVIGHGLELIPISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFC4</accession>
    <name>A0A9Q0LFC4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFC4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="70202" checksum="7BB907758D809554" modified="2023-09-13" version="1">MSDCLFFGQNQFPKLIKNEPDKITKPTQFKFENENENENEKQIKQVLRGSPFKTIFLFKNGKAIEYGEGLFRMEIKKIQIENIQKVTVGYNNKAILTKEGNVIGKVSLIESNREINISSLFEDPNDRIIQDIVSGYKSIYLLTSNQNAYGIGSNKHGQLGFDSKTLNKTEKPILIMKNVSKIFSGNSSNHVFLLNLNQELFGCGYNKYGQLGLGESMKEKKIQKLTKIQNIPKGNIIDIQCGDSHSIMLIEDEDENPKRKLYSCGHHLNNGLGKNGDTYEFTEIESSLFENDDDDNILDFSVGNTHNLILTSKGKLIGFGSNSFGQLGTGNTEDQSIPIQIELPKLRFNEDIPNYHISCGFYNSFLYYYSFLSNLEEDLIKLFRRKEFCDISFKTKNGEIIEAHKLILETIIGKDENQFEKLQKIISNKSTKESNQIFEMIYSNNPKINPKLYSEIEIEFNLFNPIEETMKELFENENEKDFIIERKEKQYKFPKLLLMMRSELYLGMFLSVTEDKSNKVTDYSELSDESFQILEYWIYSNQIKEEIQITQEIIYEIETGMDYFQLNQTNPNLLDLLMNQFDIQIQQQIQNQKRKKKLFTFYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFJ2</accession>
    <name>A0A9Q0LFJ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spliceosome-associated protein cwc27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFJ2"/>
    <dbReference type="OMA" id="SHNEAFE"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="69721" checksum="203E47412412BD71" modified="2023-09-13" version="1">MAQSYSNSPPTNGKVILHTTSGDLLIELWSKEAPLAARNFAQLCMEGYYNNTIFHRVVKNFLVQGGDPTNTGLNGESIYEKPFKIEIHSRLRFSFRGIVAMAANDEGNGSQFFITLDKCEELNKKFTIFGKVTGDTIYNLVTIGEKETDSNEKPLFPDKIISTEVIQPPFDDIFPRKIKKKENSNQIDLENQAKNNLIKDKRRRNLNLLSFGEDFNDEDFNDEDFNDEDENENQNLNQNLNQNQNQNQIQNQIQNQNQNQNQNQNLNQNQNQNQNQNQNQNQNQNQIQNQNQNQNQNQNQNQNQNQNQNQNQNKNQNQNEIQNQNEIKMDIVNEIQPNQKSLANSITKNIQDKIIPKENSKEENKKIEEEMIKLKYDILTLISPDSVQDSILNQQNQNEETNLSYIEQMRNKYKVKNSLNQTNRQEFALKKLAEFRKNLKNSKKFQGINSNQNEKNIQNKTQKSNQINNSNQNNKINHFEDEKNKEMNDANIDIDAKIEEETDEGWMNHQLVFKKIPGDYRDPMRKSENEKNQNELDPIQKIKEIEKEQHKKHRKEKHRKKERKDKKEKKKDNSEKYSNKKTRRKRKIPLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG25</accession>
    <name>A0A9Q0LG25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Longevity assurance factor 1 lag1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG25"/>
    <dbReference type="OMA" id="THAAEFK"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="57"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="311" mass="36828" checksum="47FEEE6EFBC319B8" modified="2023-09-13" version="1">MKDLISSLVFYQLGNGSCEIGQNDLFSIGFWILVVLIFRFICSQILTPFIVKNFAKRQSPKFEETFFLSVHYILAFFFGYLVLHDKYWFRLLYMAWKDRKGLWEHDGDPFPCDVKIYYAFQLGFYIVDLPFAFFKQKQPYLILAHHITTITLIGTSWYYLHYQIGTLLMILHDISDVFLYSAQAFNYLGYSTMKTACFVPFVLTFFFFRLIILPFLDYSELIEYKGRTGFVGDVLTGGLPILVLIFMHIYWFFLILRIIYRMFVAEKPVFDIRSDDEDDEVKDDKKNNDKNTPPVQTAKPKEENSDIKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGK2</accession>
    <name>A0A9Q0LGK2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGK2"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF8">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="106" mass="12372" checksum="A9F987F7E153E115" modified="2023-09-13" version="1">MTKLIPPINFGMVEDDLYRSGFPNELNFPFLEKLALKTIISLGPEDLPQKCTLIGCLRKIQRWNLATIFEEYRRFAGSKVRLNNEQFIELFDTDLVQIPEEPPSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHA4</accession>
    <name>A0A9Q0LHA4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dactylin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHA4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="629" mass="75567" checksum="86B3E9FFD7839E88" modified="2023-09-13" version="1">MIPNQNQKQKQNKTPYYQIIETFPNISYNTFLQEIYPSSKANKMISLIEKNSYNYNYYDYDYDDEYDYDYDSIHQYKGNRYKKSFPEFTNKNVDLYSNINLNFIEKENEKEKEDEDEDENEDYFDWLPEELILMIFEYLDKPSHLCICEATCSQFQRISNEPILWRNVLRKTAPYLDFLMVSSSVSKYATTVSCYFSFKGVIGICKYFEEEYERLLEQQKEENYFDKKKKLKKKKKKKKPIVHLNNDYKDSLLDPLLESDYDPNYQNQISKPTFYQNIPYDRYSESIRNLEIEKSVVRLIENNPKKLIVQQINKFESAYRLAEKGFKFYESHHQYPEKVDKALKIFEEGVVPILFSLSFLITIILSMLKLDLIIETNCIYIFIPVEIFLCCLLYIGFCFYFMKTNRNSYHLTISMIISIISTIIFLILLSIKLEYSNSFPWFIILIPHLTSFGAWIYFPIKAYRKIRDEEDYLINIIISYILIFHIPITIFMILFILYKQNISGITQNSIFIPLFIIDILPTALFIFWPIYLRYCRKHMDSWKSVRNLPKPYDSYLKINFISLFIYQIPMLILFIQELLIYLKLNQKIFIEWITVSIPSIITLGGILIFGIILEVDYIKKELFSSKYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHV5</accession>
    <name>A0A9Q0LHV5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHV5"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="152"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="446" mass="51929" checksum="A6FB14A68665D1AA" modified="2023-09-13" version="1">MNEIIFFGRNKYSQIIKNKTEKIIKPIQFKFENENENENEKQIKQIATSYFSTIFLFENGKAIEYLTDEEEYSNQNPEKIQIEENIQKVTVGFFNEAILTTEGNVFAKGRNINPNNPNEFINISSLIEDTNDRIIEDIVCSRNSLYLLTSNHNAYGIGSNHYGQLGFDSETLKKTDKPILMMKNISKMFSGISSDHVFLLNLKQELFSCGYNYYGEIIDIQCGFNHSILLIENENQNQNQNPKRKLYSCGDYHYNGLGQDQDTREFTEIKSSLFENDDNILEISVGQRHNLVFTSKGKIMVFGDNLYGQLGTGDTKSQSIPIQIELPKLRFNEDISNYHICCSDFKSFLYYSPPPFSNLEEDLIKLFERKEFCDISFKTKNGEIIEARKLILKYRLNQNENEIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKNYKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHZ0</accession>
    <name>A0A9Q0LHZ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHZ0"/>
    <dbReference type="OMA" id="RSMNATH"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="268" mass="31248" checksum="DC7C1A504E5B8DC3" modified="2023-09-13" version="1">MTSSGFFRFDYIYKQGWLWKRGHFRKNWKKRYMVLRGNVISYFPNQTTDNSKARGLIDCEGATISDYPKRTNGFLVRESTGKEFPMSAKSEEEKNEWIEVLSHVSQNKAPPPKQTTKSNSNQNLNQNLNQNENQNQNQIQNLNQNPNLNPNLNQNPIENPIENQTNLSPDNLQNVQQNSTSQSENFNPNNSIQNIDNNNNKIDNLNDNIINDDKKNQNENFNENPNQDQDQDQDQDDDSDDDDDSDSDSDDEYRNMQNQEGDEWTFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIY1</accession>
    <name>A0A9Q0LIY1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duf614 family protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIY1"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040345791" evidence="1">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="84" mass="9405" checksum="EC8976749D2A8F3D" modified="2023-09-13" version="1">MFVSICGLLCPPILAARNKSEADERECTVCDCLCCPPEYFTRQQIRSKYNFETDTCSDCLVITFCGSCAACQDAREMKSRGKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJS6</accession>
    <name>A0A9Q0LJS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJS6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="162" mass="18555" checksum="AA9BB41F4B3AB436" modified="2023-09-13" version="1">MMKNVSKIFSGNSSQFVFLLNSNQELFVSGDNEYGQLGLGESERNEKKIKKLTKIQNIPKGKIIDIQCGWAFSIILIENEIENENQNENPKRKLYSCGAYEYNGLDKRNKPTHEFTEIKSSLFENDDNILDFSVGNVHTLVLTSKGKMIGWKYRMSIFSNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK64</accession>
    <name>A0A9Q0LK64_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoporin nup43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK64"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="332" mass="37775" checksum="988331E6ADF90C1C" modified="2023-09-13" version="1">MKKLFITGSKLRSIKFLTRDEETNNSIDFVIGSWGETENTLTFYTLENPDMYDDPHISQTHTISHNGNVNSIVTYPYSSLNNMENINQRPQLNPFLLTSSNGNVTLYHIENLHNKSTPNNQRVEKIQEYKLSKLPINSIDIESFSQQLISAAGDDGNVHIFSIEQQKHKSSSQHQPPPHIKLFDIRDKNQKPNKIFLNKRNLSSNYSLALHPTNPDQIVVGSADGSISVWDMRFESLEPIVSRIHSSAIWNLMFHPIYSNFLFSCSEDGSLDRLDFNRSTLNKHNNSLQIFSSSLFTQPLAINSFDIFADLIIGVSDSQNILIGNSQEFKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKS5</accession>
    <name>A0A9Q0LKS5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKS5"/>
    <dbReference type="OMA" id="DLIFNWQ"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="171" mass="19855" checksum="DEC75CAC6CD9F836" modified="2023-09-13" version="1">MIKAVIVVNNHGKPRFIKFYDEIPEEKRIKLVKEVFQKITQRGDVLCNFLDGTHVSTEIADWSSDIKFVYRHFATLYFIFVIDSSESELGTLDLIQVFVEALDQAFENICELDIIFHPDRVLYILDQMIMGGLVFETDIKQIVFISEECDRLADEAKIKGQGRDKDPSFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLX6</accession>
    <name>A0A9Q0LLX6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gdp-fucose transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLX6"/>
    <dbReference type="OMA" id="SHHISAN"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="28"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="247" mass="28271" checksum="E91CD202BA378ECD" modified="2023-09-13" version="1">MSDTKRTEDLEKKKTESEYEKNIKMVTMTVSFYFIISMTVVFLNKYLLSNSKFEFNGALFMTWYQLIVSLFCILIISVLRPHYPIFDFMPKLEFEIEKAKKVSIVTVFFIGMVGLNNLCLKYVSVSFYQVARSLTVVFNIVFSKMILGITTSNKILQACGVVIFGFFIGSGGEIDFSLIGTIFGVASSASLSLYSIYVKKYIKILNDDHFLLLIYNTILAIIFLFPIVLLTGEFTLFFNTKLSNPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM23</accession>
    <name>A0A9Q0LM23_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 33a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM23"/>
    <dbReference type="OMA" id="NWIGITR"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="627" mass="73330" checksum="164A9A4C1D8040DA" modified="2023-09-13" version="1">MSGSVFLNNIQFVPSLNEMRETIRDKFREKMKKITGRKEIILDPKSVGSLGLMIDITIMKECGIQKFLYLKDNLPPLEKYTNRIFFIPPKLLLIKTLTNYLQKVKKFTKKEEIERYEEIKKENHYLFLYPRKTILCDEILEEDGVYDLITVDDFDLGIIPFETDVLTLELDSDFRKYRMNDISSLYYITTSLLNLQKHVGKIPEIKWIGEKSKFVAEMLKKHQEETENQNQNQNAKKSEIDSLIIFDRKTDMITPLVTQINYEGLINEVFVIKNTYVELPAKWLDFNKEKEEKSQLEDNKEQQQPVVKTDPNKRQKYVLNSTDLLFTEIRDRNMGEVGAILNSKAKEISKEYGTRFEPNQSISSLRKFVQKLPHLQDQHFSLSVHIKMTQEILAITSKPHFSDRMENELALLAGEITDANEYIENLINKQDKIQSVFRILCLQSLILNGLKQKDFDFFRKEIVQVYGHKYIFSLYNLQKFGILKLSESKSNFPQIRKIFNLINFDFDKSDDHVYSVFSGYAPISVRIIQQAFEPGWESIKNQLFLLENSSFGTIYNVSKKELIEMEEKRKKTKVVLVFFIGGVTHAEISGLRLLEKDQGNKFHYVIATTKIIDGAYVSKSFIDPLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMN8</accession>
    <name>A0A9Q0LMN8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Four and a half lim domains protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMN8"/>
    <dbReference type="OMA" id="WHKECFF"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="73"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="173"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="314" mass="36342" checksum="E58CAF21CD23E278" modified="2023-09-13" version="1">MSYEYLSSRFKNNETDHTLEAMLGKEKNQGRNEHQTVRSGNYRCSGCNKLIERGEMVEYEGKYYHRQCVDIDFRCERCGGVVIGKVVRTSTSKTYHPKCFTCEHCGHKLAPEGTYTERMGHLLCNDCVVEIESFKRNNPPRNNQPNKNRTNVDRQKQIREREQFLDNQNQGKEICGVCGKVIMKDAIIALDVFFHKECFTCKGCGKQFNETQFQMYDGFPYHPECYSRKYGKFCAGCNKEIEGKFIVALGKDWHHGCFRCTKCGASFGDEGFLEKDGKPYCVDCYPKQPQKKVVTTTKRRGFVIDPRTGQKRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNU0</accession>
    <name>A0A9Q0LNU0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thap domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNU0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF141">
        <property type="entry name" value="TRANSPOSASE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="5">
        <location>
            <begin position="177"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C19 ubiquitin carboxyl-terminal hydrolase" evidence="4">
        <location>
            <begin position="426"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="614"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1116"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1116"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1169" mass="135543" checksum="6D36F4506CAE2254" modified="2023-09-13" version="1">MKPFQIDKKIFEMIQHFKTNRKIIRSRVYEFGHDDILEEDKVIIDPQNPYGIRINWKLASTYPLLLKVLTGYTLEGFLDCFQYVKDIISPFNQRAPKRILSPEDIWLAFLTYFYSYCPFSSMEVFFGIPRASMNSLFKKFLVPIHNELKNQIHWISKKEQKKNNIGFPNYPKAMAVVDATVQEIQRPKNKTKRTLTYSGKHKKYCFKSLTIHSPNGLMMDCVPGVTGKNHDKIVWDITDWSDKCEEIVRDKNGKKKKKRYQILADSGFQGIQKQCKAVLPSKKTSAGLTQEKIHNNIKLSSDRVLVENYYGRLKKFNIMMFKFRGNMTDFRLLFNYNPRKKKSKCNKPNFFQMNEDDQFELIQDSPKSDRSSKENSPKQSKKRKMIVEPPSNPLSQSNSPKKPALNFFSDLKSDGPSQKSNLSLKGIENPCNSCFMISVLQLFLRTNGEFFNPQGSLVEKILSISQQMKTEKETVPYSYLVSLQNDLKGIKKMYGPNPSQKDAHDFLDFLLDNLRIDSLLLYNNTLNKKIQIPIRENLSLIRAHCGLEKKKIFYGACGHWSETETEFYSLNIFLHPPVANTPIHLLDLIDSYFSLIHPDKDNLMICEECKKQKKKNSNEKSTSSTKKEISLTPEKTEKLSQKTKRRRKGRKHQSKTHEVTSPKDIPKKEEITPKSQSQQFFISDFPHFFWIHLERFWWKKDGSTGKKNWPVVIPDKIDLQKYGEENWIPHNIQDISTPPCILSNQSSPLNEVDERIESIETNQSNNLKEKDLLNENNQSLYSSSLVFSSKSSQSNQIDERIESIETNQIDERIESIETNQSNNLKEKDLLNENNQSLYSSSLVFSSKSSQSNQIDERIESIETNQIDERIESIETNQIDERIESIETNQSNNLKEKDLLNENNQSLYSSSLIFSSKSSQSNQIDERIESIETNQIDERIESIETNQSNNLKEKDLLNENNQSLYLSPLVFSSKSSQSNQIDESIESIETNQIDERIESIETNQIDERIESIETNQSNNLKEKDLLNENNQSLYLSPLVFSSKSSQSNQIDERIESIETNQSNNLKEKDLLNETNKSINKDNKEYSLRGAILHLGISLKEGITLRYGGIRKMMKNSNQNKSEYSSPNLKKVENNSVLKKTEDEKTSKVDMRMLSQDNIQNLINQLKDQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP90</accession>
    <name>A0A9Q0LP90_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP90"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="497"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="774"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="880" mass="102684" checksum="B246E77A1F4D0CF6" modified="2023-09-13" version="1">MQIEYDSTLNLLAKFSNDQETVKDILPSLKEAVFKQKKNLNFSQQQNTIKIILEIMNNFRDDKNIQKDGFLILSFIEFNQENQNEVRRLNGIEIIINSMKKFRDKKNIQADGCRALAFIVFNNEENQNEVRRLNGIEIIINSMKKFRDKKNIQANGCRALASIVFNNEENQNEIRRLKGIKIIINSMKKFRDKKNIQMYGSATLFHCSCSNEENQMEIKLSKGVETLIETMENFPNDIRIQKFGTWIILNVSLQDENQISLIKNKGFEALKQLENYYPNLNNNPNSSPQFETFRKRFNIFNQEKLKEKSNDILQFDTRIFQPTNFKLLTQEEKGKQIKQISSSNRFKNFLYYDGELFQEPNSEIDEQNSKPEKIQIENIQKVSVGYQHEAILTEEGDVFAKGKEINRENPNEFINISSLIEYPNDRTMKDVVCSRNSIYLLTSNKNVYGIGSNEFGQLGFDYLKLKKTEKPILMMENVSKIFSGTSSEHVFLLNSNQELFGCGANNFGQLGLRVTEIPNISKPLKIRNIPKGKIIDIQCGVFHSIMLIEDENDEKRRLYSCGSYQCNGLGKKNQDAREFTEIKSPLFDDDDDNTILDFSVAKYQTLILTSNAKLISFGDNINNSLRTKIQSETQLVPIGIEIRELLYDISNYHVFCGVNNSFIYSSYFSSLEHDLVQLLKRKEFCDISFITQDREIISAHKLILKWRIGPHQIEKLQTIISQKSSQESNQIFEMIYGNHNIESQKLKKEMEDIFHLYNPISLNLGEMYSTENEKDFFIIRNENEISFDKLILIARSELYRGMFLSVTNDTSNKVTDYSELSNESFEILKYWMYTNSIKEEIQITQEIIEEIEIAIDYFQLNEKNPNLFDLLNELYEEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPS0</accession>
    <name>A0A9Q0LPS0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tyrosine-protein phosphatase 69d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPS0"/>
    <dbReference type="OrthoDB" id="5985842at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="138" mass="15966" checksum="2ADA5586DA20B489" modified="2023-09-13" version="1">MLNCSSLFSSFECYWNQIISTLNDIEYQINYQNGIENWELIQSPILNQNILYQIFNSSIYQDISGNVDYSIQIKSCNTTTTACGNPSNQINLTTRIDSVKNLNFESYSNSIQLNWNYPNVPIINSIPKLNHYIISYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPT0</accession>
    <name>A0A9Q0LPT0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPT0"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="477"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="586" mass="68021" checksum="B58F96B694502378" modified="2023-09-13" version="1">MNEIIFFGLNQKPKLIQNKPDRIKKPIQFKFENEKQIKQIKQISSGNLGTIFLFKNGKAIEYLNEEDSNQNHEKIQIEENIQKVTVGYQNEAILTKEGNVFAKGNDINSKNPKEFINISSLIEDTNDRIIEDIVSGANSIYLLTSNQNAYGIGSNHNGQLGFDCETLKETEKPILMMKNVSKIFSGNCSFHVFLLNSNQELFVCGDNEYGQLGLGESTKEETNIQKLIQIQNIPKGEIIDIQCGYSHSIMLIEDENENRKLYSCGNYELNGLGKNENTYEFTEIKSSLFENDGYIIEISIGFSHSLILTEKGKMVVFGYNFYGELGTGDTEYQLNPIQIKLPELRFNEEISNYHILCGDGKSFLYYSPPPFSNLEEDLIKLFRRKEFCNISFKTENGDIISAHKLILQTIIGQDDQIENLKEIISTKSTKESNQIFEMIYSNRIINPKLYEEIEIEFNLFGLIEEKMKELFDFENEKDFIIERKEKQYKFPKLILIMRSELYREMFLSVTKDKSNKVTDYSKLSEESFQILEYWIYSNQIKDDIQITQEIINEIEIGIDYFQLNQTYPNLLDLLINKFNNQNQNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ67</accession>
    <name>A0A9Q0LQ67_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter ant1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ67"/>
    <dbReference type="OMA" id="WIRNISK"/>
    <dbReference type="OrthoDB" id="438030at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="80"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="469" mass="52296" checksum="61D83BBB43496292" modified="2023-09-13" version="1">MSDEELIINKPSDSGIGTESISEANLQGEVSLNETNENITETETQPILESTSIDNLVTFRKFQLPIVTKFLKRTKTEIPKTGFLQSSFNFFKGFVCTGIIAEPYAFKEAGIVTAIISLVLLSLLSFHTMSILVTAKRFVMNKYDLQYLTFTDIGEYLLGKWGKNAIDFFLFLTQFGFCCAYVIFISGTLGNIFSKSPAIFVPVAFLPLYLLTLIRNVKKLVPYEIAGSFLLLFSLSIVVGIECVDPEKGRKVSAAEWKTLPIFFGIVAYSFEGIGIILPIENSMKKPQKFKKLMGINLFFVTIVYIVFGLLGYLAYGTDTKGNVITNLEQNPLNIVMKSAYVLVVLLTYPLQMFPAVELLEIKNCFRKHMGKKHWELRRNLLRFGLVLISSLIGLAIPQFGLFLSLIGSLGSTALCFILPAVFDIQLRRENGKNRTVWKVKNYAIVIFGAIAAVAGTVVSIQNIISALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQG1</accession>
    <name>A0A9Q0LQG1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_06897</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQG1"/>
    <dbReference type="OMA" id="DHTWEQT"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="212"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="416"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5076035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="686" mass="78138" checksum="3AAD8C4B80D02DD6" modified="2023-09-13" version="1">MSDSFEDKYFADEDEKDQTSITNFNQNDNESSSESEDALDKFMNDLEKDDPNKKNNKEKQIRNDIDEIDEIDSYLHLTGHDIGISNLEPHLKNENFLLQQKSEFEIEFDSDDNPIVDLKSRKKAVVPLDEVNHSEIEYFEFNKNFYQENPQIATLSDQEVKKIRNEKQIRVSAFDVPKPVLSFQQCGFSSLVLNILKKMNIVEPTPIQSQAIPAILSGRDVYGIAKTGSGKTLAYVLPLIIHCLDQPHIQKGDGPISVILVPTRELAHQVYLVTTQLAKPHNLIVKEITGGIKKYEQTKELKKGCEIIVATPGRLIDQIRLKGTNLLRCTYLVLDEADKMFDFGFESQVMSIVQAIRPDRQILLFCATTKRAIENLVRDQLADYVRITIGKVGVATQNVVQNTLIFKNIEEKKSWLFENLPNFLDSGTVLIFVTSKELSEQLAIEINDHGFRCGALHGDLSPYDRNIMVKGFQKGNISILVATDIFSRGVDIRSIKTVVNFEVARDVNTHVNRVGRTGRAGDKGVAYNLIMESESNFAAVLFHSLKLADQEVPEKLLEIAMQNKNFRKNSIQKLLSHKKKPKQTGKIKEVLDSWKEKEDLHLENEKNETEKNHLNFQKIFHSARRKGNKKGIGFSEISGRKKRKDKNDLQINIGSFRSFQNTFVSSDNLNSTSKKLEDDLKKPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQQ2</accession>
    <name>A0A9Q0LQQ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tom1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQQ2"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="1">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="79" mass="9417" checksum="23F819EF8F58EA7F" modified="2023-09-13" version="1">MDFQNLIEQATQSTLEEPDWTKNFEIIDQLTKNTTIYPAFLKSLRTKILNQNEQTQELAIELLFAYWKNLPFNFSINLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRG6</accession>
    <name>A0A9Q0LRG6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhogap domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRG6"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="492" mass="59041" checksum="795AE7F7B06C5B35" modified="2023-09-13" version="1">MRKWKILFIGDYYVGKTSLLMTYYEKKLPEEYLPTVFESFSNIFQIKNEEIERIEENEQNQIENQQNQQNQQNQIEIENKFQIEFWDSAIHEDNYRFLQIFCQEADIIVFCFSIIDYYSFENIQSFWIPNTEKYLKNKKRILIGTKMDLRNNEERINQLKEKNQKLITKEEGMDLAKKIKAIKYFECSSLNQKGIETIFNEIALICIGKYDKKEKKKGSIFVGSRVVGKTSLLLTYYEKKLPEKYIPTIFDIFQKTFKIEKNKEIEISFWDSERPEDRDRLFPLIYPETDLIAICFSIIDSNSFERIENFWIPEIEQYSPNSKRILIGTKIDLRNELKEDNQKLITKEEGMEFAKKIKAIKYFECSSFTQKGIETIFNEIPLVCIGKYDKEENKKGFIFIGDGAIGKTSLLLTYDLKYLPEEYIPTIYDNFSKNFKIEENKEIEIAFWDTARRDYDDRLFPLYYPWKQILIVICFAIDDYYSFENIENFWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRX1</accession>
    <name>A0A9Q0LRX1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRX1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="720" mass="82912" checksum="4647466DB33BD8DA" modified="2023-09-13" version="1">MLNFENQFVIQEKLKEPSTSAKKIIDSINSIISDKKQTKKIRSLLQDLCIFRIEQHQIDNFLSCAFKILSQYDNEKIIRLTHYLITSLGKLDLKQSTSLYNQLEKEIKSTNIGNQILSIHTLGTCLCVNTFKESFLNYLIERMEMGFQTQITPKKKGFSKKSKQSDDYIFLQTACLKVAAIRFPRSQKLKSIVLKLMESKDEEAVRLSINLFYGLMNKNINMYQSLMGILPTNATFESKFIVKKKHTKKKDEKNFLQNPEINLTSIQSQSSFLRLIEKMMVSIPKEAKPKFYNAVLLVMKYNINLEELNTGSRKNEPENSKTNESQGEQSAQTTSKVGLTHQMKHLEIFLAGIGALSSGENSWEIMHQLSINHQEFPLNKRAHNFEQFSEQKYSINDFILQQIYIIISRYNFQLRKSRSSGFSVFGDPETTSSKIDFVPEKNPRDIGNAELVGTLRALCKFVTSFNSSNPPNKFAKNLSIFHPIQNQLYELASLSKSPTIKMWVVCSLICSYQPPHNLQSQESAPVQSQQTQQLQNVYEFQNQNSFKILQEIIIKEIKKKTFTPHLFNFILKTFEERLQITPKITPVALSIFQKVSQKSIELFESSLLVSHFEKIIQFNSYNRILMETIIIILDSDPKPEFFLTLKNIKSKIIHFVGNQIHKILGLSVDSLYSPLAQDNPSTNAAKTLLDSIILRLKHFAILGDYDLQIQSILAIWKIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS35</accession>
    <name>A0A9Q0LS35_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rabconnectin-3b isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS35"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1159" mass="134913" checksum="6C5E43C8995D2DF7" modified="2023-09-13" version="1">MENSKIKLLLWKNLNSFSYSISSLLLSKNSIHLITGDLNGNVILWKFFKNQFIKKMFLLAHNSKITSIIEIIYFSEKSFITVSIDGFVAIWKFKDGLCLKLFPNLLSCSPKIIKQIPNHLFKFVAVGESNIIEIFDIEKSQVIQVLYGHDTWISSVYLSSFQVNEYTLMISLGNDGKLCFWKFDPNSNDNQNQNSDQFLLRRVTISIENIISSTFSPNEELFLVVSDLFIQIYDCKGVKIYYTINCLKNEFWKDAYFLDSFHIVAFTRYGKCFIYQIPKLEKENLISLSQAFLKADLSSKSIKTKNTRKSNDSNLLKMKKSKTEPNISSNIPHKQISFNFFENLNSPSILAILNQKLENGESTIFANYNSKFIISGDSSGSISLWKWEQIIQEVNQFYPKKINITSLSKNINENENERKKDPFITSTLFFEKESQNQILIINGYSNGEITVKYFPLSSSKPIKFIGDHSDRIITLFVAEFLNKNKSEYYLISVSKDYIICVWDLTKKIKIATFSHHIALIKYIIQPSKNQNLLLFIDEDNVVSICDPLKNQIFHILGHSKNSKIVKIYWEKSSLNLGVEFENCLLYFWNLRKGKLDRVIENQNQFYLSSFVKYPQNYLVYTRNEKQNQFVLEQRKTFQKNLNFLSFSQIGSGYNNIILLDIVLFLETMIRRLKQGKVLKNKFQLIEYFIELDNMNIFEKSLKKNPNNQEQNIEFGLVGNSNTLTLFISQEESSLDNLKKNNPMFASIVSLLSVSFGMSLAKLPKKKYQILGTQMALNYIEKMIQEMNNQHLISIFENLFKYWMHSNEDIQQSSRSILQYISNQIEAKKIIKLTSKWRQNVQISSTKTLKANNLLLLGVLCLYCSNHVEKSFQSKIVSNLIKLVQKKEIQGLIAIELITTQFSSFKQYIPNIDQFIGFVFQYVLIEKNEIFFTTSRSILFSIGFLEPGLILLTLKNEIQKNQFTKIQFEKILSVIFEIVSKKPIIFTDYIFKIVEITLQIFPIEGSSNSDNLLKIEEIFHLLSNTYQIFAYHQEIRKILIGTESKVIFYDLNNSKIEPLISYHKSNITNVSFSPNGKLFASFSLDDKLLLIWKIKNSTFSKKLKKLTNLFKSIQTPDFSSLLNQKINRKIDRFKNIELFWTNSSIISLKIESNQYNFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSR4</accession>
    <name>A0A9Q0LSR4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase 2 (Formerly 2a) regulatory subunit a beta isoform-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSR4"/>
    <dbReference type="OMA" id="DIAEVRC"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="372"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="490"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="529"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="595" mass="68060" checksum="E4EB9693CC255CE7" modified="2023-09-13" version="1">MNKMDIEKEKEKEKETINPLETFTEDLHNENRNVRLSALQKTTKIAEILGSKKTLEELIPTLSESIDDSDEDEILSTFAEEIGKLVNFIEEKYVYVLVPLLKNFLTVEESIVREKSVDSISRIAEKLTDKEIETHLFTLVNELQSGEWFSPRISALQLMPLVYPKVPLEKKDTLIVALSDLVENETTMVRRAAAKSLSEIVRIADSEIVQEHLLPLVKIIANDDEDSVRLLSIDVCISLLKLFHSENEISQFILPILESLVEDRSWRVRYSLAEQICELEHNIEPQIVVKIIVPIFVKLISDNEGEVRTRTSYKIDEFCSYIHEFPDVIVNEIIPVCSEMINEKSTNTKAGFASSISSLSTILGQDLTMKYLLPLYLEMLSEEKYQVRLAVISKLKEITNVIGVESLAKEIFPSIIKLSDDPQWRIRKTIIEFIPNLPSENIGITLIDDKIADLYFNWLKDPVSIIRDVAAQNLFKLCGFLGSDWVEQKLLEKILSLISDSNYLIRETGLKTTSLLAPVFNKEILKQKIIPNILLAQKDSVPNVRFSLAQVLGEISAFLDTETLEQKIYPCFEELKKDKDEDVRFFAEKFSSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT23</accession>
    <name>A0A9Q0LT23_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT23"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="387" mass="46204" checksum="8CEEB7231BD872A7" modified="2023-09-13" version="1">MSKNTDLKKEDEKIQIITESESENESENESEQQQQQQSDWDIFMTKFTKLFAEPFIYGAALGLGQSFGQAKKIKRKAKHQFIDLFSTTEKQEEEPKTEKEKEEKETNENPFQKFISEHAKFIPKNNPLIQNMIKNQQQEQEETEKPQRKTHTRIGQEIYHLLFENQNFRLFQNESKLISTHQVQKFLPHRTTYIFDMRTDDEHAPEILLRSGDGISGQIPHFLVENNTEILEKMEETIQLLKELSWSFPEYRKIKKKQHIQSEIQRVNNQKKQLEERIQSLSKKIENKQQNEIIFMKLDHQVNDIFKASSKIEINKSQQKPKKIQVNQSDSSFYLNLCGIQTEEPEDKKKDKKKKKKKRKKGITNWNDFQKKNKNKNKNHNHNHNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTC2</accession>
    <name>A0A9Q0LTC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_14831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000052">
        <property type="protein sequence ID" value="KAJ5078647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTC2"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="7">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="326" mass="39159" checksum="44E78E0416888679" modified="2023-09-13" version="1">MKSDIIYNELKQQYNIIEKHRQDNPLNFLELKIKFQKLGNQENLKQFQKDMEEIKQAFTIVSSHRDLILHIKNTVSISSSKEELNILQEEVPKLQKQIGVIDKQTELIQTKASKIENFKKTIINYEVDMNSAYIQSMNILSLIDKFSAYSQVKLRVFAQVEEEFAKYYQEAQDIIKELINLVTWYRLFLSAYEQLLREIVRRNQEFKRQLEIVNKCKEEFLLMYETEFRKRQYFYDFYGQYLPQQLCPSIYDFPTMFHIVPEDVENNLPSIELSYDSDNLENVNEINSTQLHHFQQQLQHMQLHSLLTPTPNFFMNQNKSNDQNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTP7</accession>
    <name>A0A9Q0LTP7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab5 gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTP7"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="371"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="960" mass="112105" checksum="7326BD58CDF5AE78" modified="2023-09-13" version="1">MKPFKRKIKESIFLRAFTENGDFLLNFLEFELSILTPVNESLKNIIITRNVIETHTIFINESNPKQFVCLNGVLGVFRSLKSMEDETQITLVQFWKKIEEDIIELIKNNKISEIFKREFQENNLDVEFESLPEVIGQSKMKFAKNCKTTSIFFINKPFDISESYQIKSSAMLKRTKKSRLENDLKIEEKKEQKESENINKEEISANIADEFLDVSDGVFEDIDDIDEKQPQENFITDTKSLDKFIQSNPDDKMISLQIRYFIKYVEKMGDFDIKEISSYIENFVATLSKKCFSHSSLMKFRPEFSQKEFRALNAFQQISLKRRCVLLDPDLLGGLMTKIKEKISNIRGLFEDYIMEYLHDFLFGVLKINNKIMDEKIKVRLRKLSKIPQLTIDFFQLPVEVLDYEAMILESKQKLITINMEKTPKKKLECLAQSCQLLLQIIEKVNMESGADNLLSFFSYILLQVNPPFIYSNIQYIDYFRKSVDISMTKSGFFYTNLLSAVGFLEKISGKDLRVHPVIFENYMRKPESKEKYYLKRLKKSQTEVPFKFKSEIIILDDSSNEEDENADESQDNSSNSHGKSLENINSFERKTNQKRQINLVHYPVNPTKIKNKSYSDRQRIDLEKQSGFQMIENENFKRKIEKDSRKDFESELNENLENNLNENLENNLNENLENNLNENSENNLNENSENNLNRNSDVKTRNRSNTIISPHKNFRSNSNINQRSSLNLNQLSKSISTPNEYLRNYSEIQEYEYEEKMDSINSFIILDYLKPTNQIPNSNLNTNSNSNTNLNTNSNTKKSNSKKSKQNSKKSKSKKSKKPKKLNPKKSISVSNPISISNLNPIKNSNSNPIKNLISNPNLNPNSIKNLISKKSSKSLIQQPLKTGEIIYSNGDLISRNQKENLSLRVSEILSQNDNFKFQNLENTRNLTPRELEDLLHEYQKLKKDFECLKTFLKEKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU08</accession>
    <name>A0A9Q0LU08_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5079008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="PEHATHN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="883"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1427" mass="167517" checksum="319D5808375D06AC" modified="2023-09-13" version="1">MEEKIKKTNFKLLVKNFPLLKEQNIKELSDTLSDKIEKIFKNGSKIIFRLEEPIFQCQINEEKEILNFEDFISMWRVALNKKNKSQSQALDENLNEDKEFSLLRQFEVLFETIQSINTYLEKFIPIKYYKQIPGINEEIKINEDDNTYSAKMEELEKNINQALKNWEEDSKNISKEQLSGILSTNQLLLVSTPLLNIQEKNKVIYPILKLIFGKKRSVPQEILHNIISQQTDNWINSSTGFFNLIKNNFTWPIIKNSLNEINIQSRTNLSNELIKQINKRDGNISNPKIFIKEVKTDSFIHNEVTMIYYLYSNYLPQREQILFCDSNTTVGDVKNFFSIYKYYNEEYSNSKKQTYQEEEKVIFSIINATLLSQTSQSEVISQIRSINFITHFPLTIFVLEGEQNAFLMSQLQEGKLIINLENDSILNEIIKKSTFFHHFKVFYSQNEGDGKSYQIRKFCNSQNDNIDYKYYLIQLTTGEIQELIVELNKIPIEKKNENEELFIHIEFPTECSLQMTDSLWQLSMWGSIEDRQAKDPYNICWTLPPNAKLFFEIPSQNDIWKYFYPLQKFQPKECSCSVNEIKFKMYEVDDQKKIQEIDDNDLKKVANLLIETQNNTLFNNFQNLDNWKQKLSTQNPDPNSFFNKSQHIIQIISNQLNPNYNFHKSFRLFYQFWNSLKKFINLILNWEIYDDEDEDDYNNDNSQQISFIRRQEIIRCWMFSVARLNLISFFSTKEGVFDNFYSFILNLQFQNGNPISIYNPNIFGSVGEVGLFIKDNFDNSNLLEFERNLHSQSISDPNFNLGGSISNNVNDLKTEYKKMLDFFSFLNSNKPQKNENSDNESSDDENDNNNNKENNENDTRKGKYVLTFDNLSKMMFIQFRMFTGFSLIISGETGCGKTALIEYLFRDILNYQFSKFNSEEELNENEKEKNHFITFNAKKYHQTLNLLQQLIHIEKENQKQFLKIKIMKDQNNENQNNKDQNKEEEVCGLLFDYGDKKNKEQEEIRNAVYRVHKIPNSLENSVLSFESLKSTQEKVYISKMVDNTFYSILNNNDKKFRDYQTIRSSFEEYISKSHSYIRKDGDSNQTNDDFKRNLAALISLRDVSRTLRVFQWLVESKAGRFLLSENEQEEEREEELFQKAIYLSLFVCYASRQTTNKDQYFEAIFERNDNLLGNCQNVIENSQEKLIESLEYDFSKKMIAKNIPLKENCLLIFVCVYAQIPLFIIGKPGTSKSISVEVIMESLKPPYEANNFAKKIELRTFRESFLQCSPITTTQGIEDVFKIAKSKTKENDLGVVILDEVALAELSPDLPLKALHSQLEESEKEISRINQDNKKIQDIIKENGGVSVVAISNWVLDPSNTNRGILLRRESTTQLGTTAQQILCTKTVGMNSMIPEIFASYLSKIYEKIVKKNKKKIQKVNQDLILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU34</accession>
    <name>A0A9Q0LU34_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Btb-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU34"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="305"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="492" mass="58721" checksum="F0ECED7136BA8059" modified="2023-09-13" version="1">MIKYSNLEKLSNDLKNLFQNQNKNEKESYFDFEIICEQNKTSFKTHKSILSSRSQYFKSLFKSKMKEYQENKLILKDVSSSILFPILNYLYSGKIKINSENAIQILIFSSKYLIDDLIKICSNFIKKNLQFENVVDILKLSESMNLNQLFDSSYQFISENFEEFIKTPFFLELEENRLNSILSNNFIDTDEFEIFESIIKWGKHKLNINQEKDNQKLNKEEKEKIQDQILNVIEKIRFIHFSQEELEYTLKEDLIPNQYLRELVHFLLLRNKENENELEEFIEKENQIQNSFIFKPRFGLNFSEIIQEKEDFKKIKEWINDNEFFYRMGLGFSAERDGFNSFEWHKKCDEKGKTLVIIKTKDNFIFGGFTSVGFTTDKSKWRKENREDEDGYIPDPNAFIFSLRNDKDNRVPVKFPIKKDEEENAIFYQKISGPNFGNRDFYLFPNLYKIDSNFGSTYKLPYGIKYGTKKAKSYLAGSYDKLIVDELETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUG5</accession>
    <name>A0A9Q0LUG5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">fructokinase</fullName>
            <ecNumber evidence="11">2.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_04284</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.4" evidence="11"/>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUG5"/>
    <dbReference type="OMA" id="DIQAYYI"/>
    <dbReference type="OrthoDB" id="10260668at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24067">
        <property type="entry name" value="ASKHA_NBD_ROK_BsFRK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000136">
        <property type="entry name" value="Putative fructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000153">
        <property type="entry name" value="Putative fructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051804">
        <property type="entry name" value="Carb_Metab_Reg_Kinase/Isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049874">
        <property type="entry name" value="ROK_cs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42742:SF3">
        <property type="entry name" value="FRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42742">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR MPRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5079263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="304" mass="33074" checksum="FF516F040BF91507" modified="2023-09-13" version="1">MLQKSLVFAGIEAGGTTFALGIAKGSPTNIIEKTVVDTTNPKETFEKVKSWFSEKKFDGLGIASFGPLELDKSNPKYGYITSTPKPGWKDTNFLGFFKEAFPNIPIGFETDVNAAALAEFNYGGHKELKTCVYVTVGTGIGVGAVVEGNCVHGILHPEVGHIYVPVSKDEEPNFNGTCPFHGCCLEGMACSGSLSKRLGIEPKELRKIPNDHKVWNLFTHYMSHLCVNLTLTYSPNVIILGGGIMQRDPLFPFIRQKTVSLLNGYVAHDLILKNSDQFIVPSKFGSNIGLIGAMEVANLEISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUN1</accession>
    <name>A0A9Q0LUN1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUN1"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="237"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="824" mass="96417" checksum="9F74DA4C3EADB250" modified="2023-09-13" version="1">MTNIPDFLKPKVEEKKESDFFYIPEKKSNNEFSTDLIPPPIIESIEPPKFLDNSNFDNIPPPIIDNIPPPIIDDDIPPPIIEESPPKEIDSFEMNENKPKKEKPKKQRKVVPQSTQEQFEKDLEKLKEMRQLISLESKKNFEVEKEIKSLDQKMVLVEQNKISIEDLQVSIIDPDQIENKIIEDEKISKKYGAFFFLLFQEPKYLAGLARFINTKECDDFLETIMFTIYGNHYNQHEERQLLILFELALRNEFKNCSHINILLRANTTVTKLLFTYTRRGPGQLYLKDVLANQIEEIIQNDDLNLEINPVLIYEEWLKKEEQSNNEQSGLKRKLTHDEAVQNPKVMELLRPRVVKLKGVFDKLLKVISDHIEEVPYGIRLICKQIKKLTLEFFPNAEQNEISALIGGFFILRFVNPALATPTAFHLIEGKLTESARRNLTLLAKMLQLLSNMVSVFGKKEIYMDILRDFMKEKKKQLTHFLDRLCEVEDLDFSQAMNNEISTNREKLFINIRLNEIYNFHDLMKKYCERISDDPEDPMKSIISTIGDAPKQVVREQNFTLELELVNQFSNVKQKKEKSKLYNQTKEMLATVYQQLTAGFTEQEMEQINFVKSIQRLRAEAKSAKDRKANRKLKKILLNMKKLLQEKTISKHGNYKKLREDIANYISQRNQEHGKIVMELETLSSVQEYVDIHTEYLRNQVKIYQEYLKTRKMSIESKQSEDLQKKKKAAIKYSFKEFDKTGALANSQIPKERQRFVFFTITPGLLNGSVVFEAAYRNRPNPICSKTIRLEELMELHQKAQNVLDLDSIGLNVNGMINLLKKNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUW9</accession>
    <name>A0A9Q0LUW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000031">
        <property type="protein sequence ID" value="KAJ5079503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="SHNNIER"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF36">
        <property type="entry name" value="CENTRIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1485"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="269"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="492"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="630"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1368"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1487"/>
            <end position="1546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1619" mass="192281" checksum="E477CF1FA73F67E0" modified="2023-09-13" version="1">MSQNSKSMDLTKREIKPKRKTNKLIKKNNKNQNPNKNIKNNNNKNNNNNNDNNNNNDILSNRKKSARKRISTLNNKTPNGVQYFPCYITEELIKKKSKKENLLDIIELNLHLNKKEEGSIHYIEKLDGLKNLKELNLNGNSIEKIYGLKNLIQLKVLDLSDNEISIIQGIDHLIHLEVLNLSGNKITRITPSIKKLSNLTELKLNNNNLTNLRDIIHLKEISNLSILSIQNNPISELDHCQDFVIFYLPNLKKYNEIPVSDEMREHANQRFRRQELNKLEEDLKNLNQKYSKLKKQYDELSEKFEDQEEELSKIISENNKLSHENNLVKEQLRTKSGLLVKKTKELTNTCELLYSVQQELAFYKIDQSFQGDWNEFGGAFTWKQTSDGPSIVFNQIPLQQDNVDYKKPRAKKSLEFIENIEKFDNQRKHFENISNEKEQEIYHLKAKQNELEFKKRELEKGVIVMKNIMEKQTADYIKDTESQPKIQEMENIQLARLENEKNTNKLKEILEEKKKLYSDMKSNNSILEKGNPLLSTEKIKLKKEMQAIEEELQNINNKKERLDKYYAELEQENKKIKTPIAQINQDDFQIIKPILSNVIDNKQLQKFEKEKPQKILESLETELNRITTFGQKTQEQIQQLQKEKQFTQSQIIQEEEKYKKIKEEFNEELTEKEDSLPLDGKETITENPVKSRMIEQKLNQLTSLLREKDSIIEKQRQEINELTEQQEDLIETGFGGEILQESIAHFRSQSLEKPTVVMIDQSTNTEEFFSSQQEKENEEMRNQLILLNRQNQEMETRIHNLKQEKMELDSKKKNAIIELKVVDPEFAEFENIPSIDFLDKMKDAIIQQQSQLEQSEYEKAMMIQQKNNNNNNNNQEKVMVEQEIQTDQSIISQLEMKIKNYEEQIRDLQENSMNKPLTSEEEKLQIQKQKEQFLNSISELQNENKKLKEEQKENLQKLVNEKGELQKELDKLNDEFKKLKIENGRLKEEMEIKNEELEKMQKEKVPKDGNENENEEQQKLEEFGDLLEIIKSKKEKLKQLDEQIKSKELEMENKKGKIESKKLKLLELQKEINKIKQEILEKAEVNEELEKEIERKREELEMLNQEEIDEDFLQQMIEEKEMLEKELLQKDEELKNANSKLSKDLEKLKEKESKYTQTEQDSQQEDHLKDKLLKLKQQKIENEEFGFDQQKSLLKPTAQSILIRKLNSGGENDQEMVQAIQNMKEELERDIDKMIELLETNKLLKNEIDQQIKHLENMRNQTKRELNEAKDLDNYNYIDDDNDDVDDLFRSSIRVIPKYGIEKPIEIEYPHFLKRSSRSYFDFRKRNNSQFADSLNFKLKSNSGRFDNTANQSNYLSRSQIITKPSLQNEYENENKILKKENQTIKNENEEMRQRIQKLLREIYILKEEMKQKEDEYLTLKNIIEQKFDFENEIKKDDPNFQYILAKLKEFIRINKKLEYKLKRIEEERTEQFNILHKSLNLEENTNSNQNQNQNSNQNKNQNLNQNQNQNSNQNQNLNQNQNLNQNSNQNQNLNSNQNQNLNQNQNLNSNLNQKLISSLKHQRNPFLENFLDKLHKKELGKLSKEISHKNSLMFSALKDLRKASEKCNLSLSLHKSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVA1</accession>
    <name>A0A9Q0LVA1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ornithine decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_04381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVA1"/>
    <dbReference type="OMA" id="FTCYSVK"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="12">
        <location>
            <begin position="52"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="11">
        <location>
            <begin position="293"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5079360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="48677" checksum="D1BBB8E8E80C60A6" modified="2023-09-13" version="1">MFLDNIINDPDTKPYQIPPLTKTPLVRKLQEKIKQILSTDQKKSFAFVYLPEIVSRLEEWKKNLNRIKPFYAIKCNSDPEILRLMANNEDFGFDCASAKEIKQILTLGVDPNRIIFAHPCKPKSDILFAKQNKVKKTTFDSIEELDKISSIYPEAELVLRIKTEDQSSFFPLSTKFGANIADVEKILDHALKLKLNVIGVAFHVGSNCQESSPYIKALENCYNIFEMAKKKDIQMRLIDIGGGFPGAGEEISNTSNKGRFLDFSKDISEKISELFGEGNIEFIAEPGRYFATTTTTLVLEVISKRLVVDENEKKKFQYFIGDGLYGCLNNIALDHCEPRAYLVRKLRSDNEKEVFQSSLFGPTCCSMDCVAKSIMLPELYVGDWLVFYNMGSYTCSIATSFNQCFLEDFYYFSDEKDDILHYQIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVJ3</accession>
    <name>A0A9Q0LVJ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Syntaxin-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_05006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVJ3"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="86"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5078218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="318" mass="37397" checksum="DF3F4AFA0E06CF72" modified="2023-09-13" version="1">MIEPASFQDRTEEFFSIIENLKTQEKEIFNKKQNNNEKTQKQKKKTGFMIAASYIGKQIYSTCLKLSKLSKLAQSNSLVYDTSQEIQELTHIIKQEIQELNSKIQELQTYLNNNKPNNSQSSNHTKNIIDSLKNNLKNATKDFQNVLEQRNENLKIQQERKSRLGDDSNINMLKQQQTPIYHRPLTYEADPLNQFVLNEEQEKKSGNQEENFFEDFQTQKTIANQSTRYYQERVDAVEDIEKTINEVSSVFNQLSVIINEQDVQIDWIEKNVEDTLVNVEKGETELTKYMQSLKSNRWLIFKIFIVLIIFIIIFSLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVL9</accession>
    <name>A0A9Q0LVL9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVL9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="481"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="588" mass="68637" checksum="B49587A65BAB3CBB" modified="2023-09-13" version="1">MKNFLFFNLNEKPIRIKNKPDEIAKLIQFENENENENEVKQIATGNFSIILLFENGKAIEYSEYSIQNPHKIQIENIQKVTVGAYNTTILTIEGNVFAKGEYIDPQNPDEFINISSLIEDTNDRIIEDIVSGYNTIYLLSSNQNVYGIGSNEYGQLGFDSETLYKTEKPILMMKNVSKIFSGISSYYVFLLNSNQELFGCGYNETNQVALPESITIRKGVRKLTKIQNIPKGKIIDIQCELNHSIMLIEEEDENRNPKRKLYSCGYCVYNGLGKNKITNEFTEIKSSLFENDNILDFSCGYENALILTSKGKLITFGNEFGQLGNGNTNNQLIPIQIELPKLRFNEDISNYHVNYRYNNSFLYYSPPSFSNLEEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLNQNEIEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSKLYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIQITQQIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNHNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVQ8</accession>
    <name>A0A9Q0LVQ8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_04190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="LQAQVYF"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14890">
        <property type="entry name" value="Intein_splicing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="12">
        <location>
            <begin position="668"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5079877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1588" mass="180461" checksum="EA6E3EF5F426C868" modified="2023-09-13" version="1">MDFNNSNIQMEDEDEDELNQESSWKVISAFFRQKGLVRQQLDSFNEFLEHSIQEIADSTEEIKVFVEPKHTPGLSYVDAVESYSLKLEKTFLTPPTITQDDGTRKSLLPNVARLRDLTYVARLLVGVELTNPNGEIIKTEPPPELGAIPIMVKSSYCSLSKCPTEIDLVQAGECPYDQGGYFIIRGGERVLIAQERQANNRVFVFKKKQPSKYSHVAEIRSSEGPLKPVSTLSVKLMTKRTRQNFEGPPMSATIPYIREEIPVVVVFRALGFIADRTIIDHIVYDTHDREMMDALRPSLQESFVIQDRETALDFIGRRGHRVGAVYDKRLRYAKDILQKRMLPHISVEEFQETPKAYFLGYMIHRLLLCSLGRNQEDDRDHYGNKRLDLAGPLLASLFNQLFKRLIRDIRKRLTTQANANGVDSENLRNIFNSQIISDGLRYSLATGNWGASRSQDQKVGVSQPLNRLNYIATLSHLRRVNTPIGREGKLAKPRQLHNTHWGIVCVTRDTKILLGDGLNTLQAGKLEMNFCDSSIATINSSTLKESKSGIAAFQTINPTILCKKLYKITTISGRQICATEDHPFLTISGWKRAENLYPNDLVRVRPTLVDLEDIYGCENFATPLQIIPSLKDIPFESYKELRSFHEISKLGLIPLMSDNSKMELISRILGFFFTSGMLDIQNALCSFHLRERRDIQVLSNDIQSLGFNDAGSPNKTIKITNGFKYQIGGLFYAFLTLLTQKSNTRNFPNWIHKCTRVIQREFLGSFFGGGDASSFLVKLYNKNAKICTILPMYIRTTKSNIKELGSIRQFLTEIQSMLERFGVSSFPTRICKRVDEENEIGFSITQTEENIHKFITRIGYRYSTHKDYEGRYVNEFLMIKKHYPYYLETFLKECEAQEGTIYVRIAKIEEIEDEIVVDFTTKNEDHSFVANGFVTHNCPCESPEGQSCGLVKNLALMTTISVGSSTESILEVLDEWTVETLEEIQSNAILGSTKVFVNGNWYCIHRDPKKLVDALRQLRRSGDISREASIVYDVAQKELRIQTDPGRCSRPLYIVKDQKLEIKKSHVARLERESNNTWETLIESGLIEYVDIEEEETAMIAMMVDDLKRAQQSQEKAYTRTYTHCEIHPSMILGVSASIIPFPDHNQSPRNTYQSAMGKQAIGIHALNYELRMDTLAHVLFYPQKPLVTTHPMEYLHFKELPTGQNSIVAISCYSGYNQEDSVIMNQSAIDRGLFRSTFYRTYTDIEEEIGYGGKEQFEIPQRSDTKGIKPGTYGKLDIDGIVPPGTRVVGGDIIIDHSRSNQKDSSVSVRHGEIGVVDKVVITHNEANKKFVKVRVRSTRVPEIGDKFSSLHGQKGTIGFTMRQEDMPFTAEGITPDIIVNPHAIPSRMTIGQLIECLLGKVSAIDGVEGSATPFTIEQTVDKISDNLHKFGYQLRGNDVMYNGRTGRKMAAQIFMGPTYYQRLKHMVIDKIHSRARGPLQELTRQPVEGRSREGGLRFGEMERDCMISHGASRFLKERLFDQSDYYSVYVCENCGLMVPMKNQTKTIICNNCGNQKTEIARVEIPYAAKLLFQELMSMSISPRLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWL4</accession>
    <name>A0A9Q0LWL4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWL4"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="245" mass="28109" checksum="E881B5E9C9F58269" modified="2023-09-13" version="1">MMKNVSKIFLENSSNHVFLLNSNQELFGCGFNSYGQLGLGESNAESEINKLTKIQNVPKGKIIDIKENFIHAEIRNLMDLAKDEKTYEFTEIKSSLFEDDDNILEFSVGSYHTLILTSNSKLIGFGNNSNGQLGTGDTKDQLIPIQIELFEFLLDYDLSNYHVSCGAFNSFLYYSPSSLSNLEEDLIKLFRRKEFCNISFKTENGEIISAHKLILKYRLKDENQIEELQEIISKNQLKNQIKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWS0</accession>
    <name>A0A9Q0LWS0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000012">
        <property type="protein sequence ID" value="KAJ5080170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWS0"/>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="372"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="724" mass="84251" checksum="167B4BACC3C166C5" modified="2023-09-13" version="1">MNKNELTIVMAGDGGVGKSCITIRYVKQIFHDHYDPTLEESYRTQVEIDNSVVTLDIIDTAGQEEFKVLRDTHLSQGDGYILVFSIIEKSGLDEIEKLRGQILRFHDIDPTEPNTNPPFPIMIAGNKSDLEEYREVPTETAKQMADQWGLPYIETSAKNGTNISELYAECVRMVRKYKKGPTTDTPNTEIKTEIKTQPKQIPKEKSSSYFIDKEENLIITKSSILEVYSVKNDQLILKFQAKMFGLIEDISSTKISIIYYEKSIHNIRTIGMHYFEDQEMLEKQHFKHKPFLKKDPRNSCFGFQMDNIFLAILPITEGNHWATIFNDQSFQVLQDFPENENENEKENQNQNQNQNQNQNQNQNQNENEKENQNQNQNQNQNQNQNQNQNQNENENQIQNQNENENENENQNQNQVENENENENEMENQNQIEMENENQNENENEWDLEKIIQDVQSKQKIKNENENEKKEDKNLNSNSFSKSQNRPLGSFYFGNDQTKSVISEPFLINLKKQKLFDCVDFCFLEGYFEPTIAVLHRGFKKKDRKSKHIEIICFVTVLSMDLITKKDYVIWRKSGLPADSYSIISLPISVGGGYAVFSQNMIFFINEHHNLAIATNAYPFSIPQIAEQYYKRFNIKKDYINKTTLDSYHRDVIDATLIKGGAISISTSSCTLNDKYLFLGSKMGDSFLIKYNLNLETLADTEHKFPEEEYSMEDELNLQEKDVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX84</accession>
    <name>A0A9Q0LX84_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX84"/>
    <dbReference type="OrthoDB" id="495719at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="425"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="660" mass="77070" checksum="D83EF131E0429D9D" modified="2023-09-13" version="1">MNWEKLSFDHSIPCARGFHSIVNRELQRELILFGGTNNEHSFNDLWRFNYEFLRWEKIKVESKEKPSPRHSCTGVLVNDDEKLLIFGGFTGHYSGPLNDIWIFDFESNKWEEMIQKNTVSGQKDHTTCVLGNRVYTLGGAQNNAFMRDLTNKFQCFDITTKKWTELPSFPFNIRWHTMVAHKNQLIVFGGYVNSQYSNQTWSFDIKLNQWIEIKPSESFIPETREGHTAAMGLASDAQDNIMFVFGGHKYDLSTSTRFYLMELLALDLESKAWIRIKESGDISGRKAQSLNIVKNSRGSFIIVFGGRYRDPQLDFHYFDEFYMMQLQFSASLLHLYARKELCDLEIKSKNGVLLAHQLVLKLRLRENYSTFLIRCLGETWQNVDIQLKNIYGRYSSSIPKVFDNIPLKNFQDDMLVLFRDFEDSKDFTIVVQKSEKEKKIRVHKLILAAKSDLFRGMFLSVVDDDSNTAPDFSGRSYKAVKTLVRFLYFETLPSSTDPIVAAELIDASSYYMLSSSFLNILCYQIIHENLNLQNVIQIFSIISKKLYVDEAYLIRDECLNVFQKHFRVINKEFQDLLNINEAIEVIQSLILSQSQLNTLLKSCDSIKDDNFREEIKKEVEKLIEKSRLHSTKIESQPQTESDNSKKKKKEKKKKKKFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXI1</accession>
    <name>A0A9Q0LXI1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXI1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="140" mass="16737" checksum="275DC432B46203A5" modified="2023-09-13" version="1">MDNNNNNNNQIENANQIQNQNEMKNLEKKVTKNLIEDYSNLLNGNSFKDFSILLRINQILLKLKFINQFYLQDLLFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXK2</accession>
    <name>A0A9Q0LXK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXK2"/>
    <dbReference type="OMA" id="ANIQWTN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052503">
        <property type="entry name" value="S100-fused_Epidermal_Struct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22571:SF51">
        <property type="entry name" value="FILAGGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22571">
        <property type="entry name" value="FILAGGRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="746" mass="87708" checksum="9BE038CB1AC33196" modified="2023-09-13" version="1">MSQNVEKILKEIHASRKDLLHIYNYIKLLEQKMETLKQENEVLKKELLKERNEKKEIKPKEDENENENKKQIISQEENEKNEDKIPDDFEFTENDSTFVNPKKESKSIEKSNEKSKEKSKEKSIEKSKGKSNGKSNEKSKGKSIEKSKEKSKEKSKGKSIEKSNEKSNEKSNEKSKEKSKEKSKEKSKGKSKGKSKGNKDNVVKTHKSHHHKKRKNKQKNQNQNENEDENENENENENENENEDENENENEDENENQKISEKIIPFYTLESKEIANTLKRIIMQIAVDIKAIKTHEDFQNPILLAEFINSINPSIQMNLIDNEEKEKSIQLILTTAQSFGCQIQHISPESFINSKIHLIDFAYEISKVKIFNFFPSNFPDLVCIFQTKLPTKSKKRIDKITELVHDLYDKTPEKVIFDLCEYFLHKPLENPLLDISNPENLAKIINTRSKNSVKISKNDNIELKAKKIMEALKKLKSRRYINEKSIVSSSFYLNLLFLLKFFSKKLTIKSELKKEDKELIEKICEEKEANIQWTNEKTYRLWITHILQLNSNHISNWKQEIENCTLLFKAINKIDSKKIEWKKVIQQNSNIESIKQNQTYFSSLGFQFSEENLSENIWQVILFYYQKKLKISKKKHIPKIQKEIDKLAKSTLKSELLKSYKEKLSSLSEKTQFYFALFDSIIQKTIDLELINKSDEDQNEELGYLFYLVNLIRKFGGLILFQPKDLLQENAQLETILKAEILLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXT8</accession>
    <name>A0A9Q0LXT8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000007">
        <property type="protein sequence ID" value="KAJ5080569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXT8"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="114" mass="13982" checksum="C86AF0AF9D55451C" modified="2023-09-13" version="1">MKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIIDEIKIKIKIKIKIKIKIKIKIKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZB7</accession>
    <name>A0A9Q0LZB7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000006">
        <property type="protein sequence ID" value="KAJ5080610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZB7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="136" mass="16547" checksum="8332726A17D1D602" modified="2023-09-13" version="1">MEEKRKKTKITKRSLFKEKQGIKLNVKNSILNEQIFLNYTFPFKFFSPNSQIQKTPFCFNISFILNSLGYYYSKQFLVQDSDLSFAFDFFFATVYYRSNCLDQKTIFQFRLGILRSYLWHKNSKKKFLKWKELVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0M066</accession>
    <name>A0A9Q0M066_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin ligase protein chfr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0M066"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="92" mass="11057" checksum="E40CF4B95B9D2029" modified="2023-09-13" version="1">MSQVIQRDFEIIEEIEQIRKEVKKIIEEDETKYKEAKKMKIKEKEEDEQKNKCDICGNPKTEICTLKVCPHTFCRKKCIESYVQRKTKMSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4P0</accession>
    <name>A0A9Q0R4P0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fip1[iii]-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_13213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4P0"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044976">
        <property type="entry name" value="FIPS5/FIPS3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36884">
        <property type="entry name" value="FIP1[III]-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FIP1[III]-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
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        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAJ5067164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="467" mass="55088" checksum="50EB56FEE1482DA3" modified="2023-09-13" version="1">MSTNIENQNLNENQNKNENQNKNENQNENLEISINEDKLNIPQQDDTDTDDLSSEDENITIILQPENLPRESTPIQTRKLGQPRAHKSIFEMRGFMRAGSLADPNYVLNCSGRHPDDPTKSIFEFDIDKAEKKPWLTPGVDLTDYFNYGFIPETWKKYCQEKIEAKQNNLHQKQIEVFAKTDKTKETKPKKINEQSNIPSNPPRFQVPPNSNDFNPMPFPFPFPFMLPPNLHPPSLKTTSQKPSNEKETITKNQENKQNKDDNKENTNQEISQKPKTENDPKNSVNDPKNQLKIETHPLQPPFLPNQLNHMFPHQNPIPFNFGPFPPFPQMRPPNFPQKPTEQDPRKRKYEPPQAKYNPQNESQYHSDGSRGRYAHEKPINFEREENEKKEINSNPHHTSRYDNTERFQSSNYDNKDRNPRSHFRDRKYINEREKFDEFKRRDDRDHSGHRSSNTSYHKNYEPNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4P1</accession>
    <name>A0A9Q0R4P1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="132" mass="15897" checksum="3D3AE5E4CD42D0E0" modified="2023-09-13" version="1">MENISLQNLEKEIDYKINNVIKELQKTENQNQKLDNYISQISIYEEKISDYEKTIIFLEKESENIENSLNNLQQNQNIEQKSEKLKEIHLKFLQLKTEKEQTEKLFSELNNLQTKSQKQFEEIETLKEIENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R543</accession>
    <name>A0A9Q0R543_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP001149090">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
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        </location>
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            <begin position="79"/>
            <end position="89"/>
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            <end position="108"/>
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            <begin position="122"/>
            <end position="148"/>
        </location>
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            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
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            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="23349" checksum="E98586FAA516BB82" modified="2023-09-13" version="1">MNENEIKQEEIKQEIKQETNENEIKQEIKQELNQNQNQNETKLNTNEKEIKQELNQNQNENENENEIKQELNENEIKQELNQNQIKQELNQNQIKQESNENQNQNQNENENENENEIKQELNENQNENENQNENENQNEIKQELNQNQIKQKSDQNQKENQNENENQNENQNENENQNENQNQNQNQNQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5I4</accession>
    <name>A0A9Q0R5I4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5I4"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05467">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32518">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32518:SF3">
        <property type="entry name" value="4-ALPHA-GLUCANOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Starch-binding domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="393"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="502" mass="59472" checksum="96207A3572BA5D39" modified="2023-09-13" version="1">MNFTEVTFYYHYKYTNPGDSILITGNILEFGFWKPEKGMELKTNSKLFPIWKVKVFLPSSIKIQYKYVIKKANGNFNWETTGTWNNRNLTISEEESQVVFDNFSLFFNVSTQGIKLLLENGHSLSEGKTPLIYNIYYDYNFDIKNVIDIFLKLGVDINEKDDGNTALLTSLSYQPQPNLIEFLLEKGADPNLPNKTEIPLVYCLKYTSYYYPINEILKLLLIYGANVTLDCFPLVFNSNDLDRLKLFLNFCNYQFIQKVLDQIKIDNLEMKMLIPRFNQINQDLHFLLNEGKIISDFFIKDKNGNEYHLHKSILRSRNVIFQQFENFFKENETEDIQDFLEWIYSGNVNNSDILFGNASKLIEGIPNKKCFYQKCYRKGIVHDLKKLYSNQETNCVILTEKNEEIKVHKEILFARSKSFREIISSFNQKEEIQIKLDKSNHKTIENLIKFIYTDKIDFSNLSEIFYDLEELIDHFELSPNNLLEYHLITFKRINQKFWYKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R768</accession>
    <name>A0A9Q0R768_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rab gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAPVD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5069028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R768"/>
    <dbReference type="OMA" id="IMENHRA"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="8">
        <location>
            <begin position="137"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="9">
        <location>
            <begin position="736"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="917"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5069028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="948" mass="111132" checksum="2C51BD1EAA17654B" modified="2023-09-13" version="1">MFDFDDKSSFAELVKIQKLLKKEKTSESAEQKIITNCKKEIQKLTRQLQVNLVEFINLSKFSESLTESQVDFSLHYEQKKMNEWKVEFYDFVDLPLSNLQTSDYQKMITLLRQNLEVLGRAIIVTPGMKREYTEILSHSAIPSLLGHLCNDHEEFKMLNQVCFEEQLKLVPDPRELLISNKLLSRLISAYTKNTHTSLFLLSSLRNPILSILQDPIFLITNHSSEISKEVNDKIISITTSLLQSLEKKVPLLPYGIRFITKKIISYCHKFKREKDQDKIISGFLLVRLINPALITPGYYKILKKRKINKILIFKKNKRYGIIDDIPIMENHRAIFQQIAKILLSLCSTKNDPRSSIQKMFPELTNLGLSLSKFFVLVGNVIDKLKQHDTEENDGEKDDFFFETKPILKSSLVTPNDLFALHKLLFDYGTTLQNNIKNHSHLAFPAIKHIFQIGKPPELIPAKQNKYFEFSFESFLPQVPNMKLFKEKTEFRGKSFFSRSSNYRPLYLVNPVSFNKTDVELSVLHEQIEKKLRQTLCLIQFENLNEYKEKSLLEILEIEKEKSLGRSSYEVFCLLDSTIRTIKKRPQQENENIYNFFLVLLKQNYTERLTKLEKMNKEKNRHLGIANRLRELVEQSEMRMNFFEQFIQSWASRSFVIKYNERLKNESEKLQNAYSKQDLIKKIADFFDTIQKCLRADLSFTIFSNAYNILSISIENHVFVDIYDEIFYPKCLKNSYEKEDILFSNKINKVKKYLTPTILHIPEQFWSTDMWSLAIEELKTLNHYKTPSLKILVLAHCAKIIFNILEFNGITEIGADLIFPIVIYVILYSNPPNLPSNMHYVEMFGDRESLNHEHEYWLTTFKSGYTYLFEIDMEVTKSEYERELKKEKEKEKAKKVNIDSSDGIDLLVDSDGINDDISFEEKNNSDVDSYNTIEIDSESSKKEKSNDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7E2</accession>
    <name>A0A9Q0R7E2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ACIDIC ribosomal protein P0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7E2"/>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="5">
        <location>
            <begin position="114"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="329" mass="36457" checksum="3952089CCCCEF8A0" modified="2023-09-13" version="1">MSGDRTRVYSQRKKDYLIRVGEYLRKYKRIIVASCNNVSANQIQSIRKTLLGKAILLMGKNTMMKKAIRENLNVDPKLTQLSTVLRGNVGLFFSDENLNELTEQITSLTISAPAKAGAVAPNDVIVPAGLTGLEPTQTSFLQALNINTRITKRQIEIISDVHLIRKGEKVGSSEAALLSKLNINPFIYGMKVLWIYDGGYLYHPKVLKITPDMIGNKLRKGIEDMTALGLALNYPLQTSVPYLISNTFQDILALSIATGFEIEEAREIREFLADPSKFVVEQEPVDEPEKKDDNEDEKKDDAPKSDKSDQQDSDDGSGGDLFGGGGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7E5</accession>
    <name>A0A9Q0R7E5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase faf-x-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="1822"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2109"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2217"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2325"/>
            <end position="2361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2451"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1638"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2126"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2138"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2223"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2258"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2270"/>
            <end position="2284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2943" mass="348374" checksum="F4B8D3C3D4EB2D3B" modified="2023-09-13" version="1">MSEKIKLKEINYEFLRDKPFTPNFFTYSEFDEMDTDDFQTFKTSLREIIHNLKHTNSITFKNSLYSIIELIQAVKKMSLGTEKQEKLLIDIGLEHIINAIINRRDIDLDFTSDIAILFREIIELIILKIKQRKFTKLIELLPILFSTSSYSWDNPQKFIPFDRNYKKKRAIYISPLSELEYIAYKSDSESESSDEDDNVSEQFRQLSNDNKSEIVIYNLLKIPKHLKKPNFLFATILFTDYKTSLFLLENIQHFGHLNGFNELIKQTGKLEIDTLLNLARFVHMIRNFFAFEFAQDFLSSYIEKLTENLEFLWTNPPTNLPTFSRDSYRVIEIIDRLDWVINKRRHKLAPSVLISIGQKSIEQDNTSTQYLGWKFILGVLQIADKSLRNLATSKDIAYPDLEEQYNSLNELIHKIITWLCEYRLIEKQLLRNPKFKYIFDLLFNILLQMAIREKIPKITIEIIWYLMFNMEKELSQIEKEVTQIIITDFGFEVVDPEIYEVPNYHKKEENLQKSKVEKNNQKKQKPKKDSNTDKEKGDDSDDSDDSTSVSDSYDEDDDYDYQVKTNNENVQEEQSQPQNKLEIDIWRILANSISFIAKFEKPENLQFINDQVANLKPSELTDDVIKVISQFIVSSATRKKKIYRIQYTSHCLYKLWEIVKENSTYPLHIKNSAKKEIRKILLHPECSIHREFYKRLCIKNITKHTSVLLSLEMLKVILLVFKEELTDEQKPKKIRKRINQFERRHHFLNLFIKDFIFYNQIASDSAAKIRQVSKGISQIQKENKTGDNQIIATSFNIDLKTKSLVGEQPHSMEINGRLTFLDFYIMKSTLYLSYIHLSTLWELLYLKPISPEETDQFFLWICKFDSTRAKFPIQFDDLDKFFQDNLSGMNFLKLTITGWEAIRRLFLALNRTSKRIFLNDKIDIRSLTQSSVFKYSLQYSQLLHFNVIWEIVLKTSNIDVAQNCIDFICKLYLSISPKANNPTTTIWESLIDVVLNSIDKANFNLSRIDMINGDEKERKAGNVFLLQIQRCALMLDNFVELYVSKYQTRTTDPNSIASHRKKMGFHQVNLDIKVDRDQSRNFRISLHDSTTISELKQGIANHLNLKLTDFRIHFHQNELHYAYEKKTLRNLGITGSSLFILVQLLNYSENYSEQNYQTINQNQNQNQNEFENENEFENENKKSKNKNSPKKEIKSSNKKNLKNTAEEEQNSIYQNESDPVHPKRFPIRVLSKEKNFHTLFDLLNLPAKISESLWNLIIKLPTNAKIFLKFNKISSEIQDEYLFFQEEKTYQLLKTEHVSAKAKELFKVIHLDWDEVLNPKKGWFSFYYSLQIIEALMVRGIKTQQQNAGFFNEKNIKNDEFCTKFISKRGHVQLLSAFITFCNDIANVQEQSDSQSFIENHLYIFPIITVLLNVLEFTSSGDYFDFKSIPEMHLNEEVFAQMMLNDKQLPKEILVAIHKLLSSLPQISIWEKIPFESVDDINYVCNGACGLYILLITRFPDLFEYSMSQIPSFQKWIMQILLAQKNPLIRRSIINFLFILATKTNLDSRNIRSLLRESEQNSQVELKSKNIVCYGKNIPMKFIFHHTAGLLSQIHQFEITCEEYFSMIVRFIEYIQKNPHQNFEKEDENDSKKKNKNKKENKNKKENKQEMNIFINYEIEEESQNQKDSVNQIPSIDLNQILEDYDPQLIDFLVNRVKEKQVIETKKIQDNILYGFLQLIKQILQSYPEEKQTRIGIQLGFIDELLNTCLFSFFSNKKPKCKHPLTRTLAMDLIACLINNNPQNTQFLFKFLTLQAKHIQPTKDWIYGFKSDNEEEFQSKYVGLKNQGATCYMNSILQQLFFTPEFRRYFLDVRKKHPLFSSFAKDDKLQSTFSSKKDLMKKNELPKIENDSSIKKPTKEEELKEANEVFVNLQTIFAFLQESESIYYDPMHFCKVFKDPTTKKPINVHQQQDANEFLNVLLEKIEKSLANTNKRYLLNQVFGGELIHQVICNNHFHSSQRIEPFFTIDVQVKNQRKLEDSLNTFVQNDLLNGDNQYFCSACNEKTDALKNCCIKKLPNILIIHLKRFEFDFERMENIKVDTRFEFPKELNMKPYTLEALNLHLNENEKQNEKQNQNEKQNQNQNEKQKQNQNENEKQNQNQNQNQNQNENENEKQKQNQNQNESESDLFKSDSSLFQSNLIENENENENENENENNDDEIKNQFEETVENDMINNIFDQSNENEKENEKENEKENEKENEKKNENENENENQNQNQNEKENENEKENENQNQNQNQNQNQNQNEKSKEYYEYELVGVVVHSGSSNYGHYYSYIDVAPSEETFLIENENDNEIEIENQIENQNQNQNLKKKQEQNINIEKDESVGNDLFNLLKSEPETTTKSHDLFENSQNLEANQKFKQNPKKANWKEFNDTRVSDFNLKNLEKETFGDWEDNSRNQIRHRRFNAYMLFYRRKKIQIEFKEEEKSEEKSEENLKDIQDVIEQIQVKNNFQKLEEDVYDYTYANFIWKMIEQDHSWMSRMDSFENSMQTKPEQLTLVKFSTIFCLNVISRAHDAAKFTEWTKQLEVIYHNWEIASKWFIYKILTSKWWKSFLIECPFSQMKDSFVNLLLEVFKSVHHSDKNIYNDFISLSEFQSDLKSFGENEEILNKDFDSNELIAKSILIQLINKMIGNVQKYIKVGILPHHYLQVIENFASLGKEEIIYLFSEKTLEILFQLFNTKCMNVLYEQRMLDHQKKGFSIESNKYETVESVKPIHFKSIVEIVRLIISGIILNQNENQNQIENENENQNQNQNQNQITLQFFKKYKDFFINIINQNVNNNSIIRLIHSLNSTNQEITEFFEEICFNELHSKRLSDINIESFTDILFGILRIEEDDNLKQTQKIMNKLAQTVIDITYNQGYAKILFKKIINEAKTHPNAKKYILQNPDLWSSIGSQLGANLKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7N8</accession>
    <name>A0A9Q0R7N8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7N8"/>
    <dbReference type="OMA" id="YELMWAC"/>
    <dbReference type="OrthoDB" id="17763at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="260" mass="30229" checksum="4C97810CE46EF192" modified="2023-09-13" version="1">MQENETKQRKGKETKIIEKNNKEKVEKIEKTKTQFKHAKFIRISGIVLGIYYILAIGVSRYITRGPDSFYDNWWVCNAGMILGVIGMLTLKLQMVGGACLLIFFPSIFWCIDVVSYLVAGKLPLGSASYMFKDDTPFLEIASTTHHLWYLPFALFIISLETRININSWLISNVFVTFIVVGARIFTPKYTLLPDGRNFLLNINMAYNFWDDCPIKFMHYFDDWHPVVYLTYMNFIGYFGFHLVAFIICRTISRLISRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7U3</accession>
    <name>A0A9Q0R7U3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7U3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="507"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="612" mass="71226" checksum="65A271DCD3526F2C" modified="2023-09-13" version="1">MNLFEKNKNDKNDCLFFGSNENPKLLKLKAEIIKNPIQFKFENENENENEKQIKQIKQIKQIASSYFGTIFLFENGKAIEYLKDSKQNPEKIPIENIKKVTVGGKIEGFLTSEGIAFKKEKTIESQKIKGYINLSELIEDPNDRVIQDIVCGSRSIYLLTSNQNAYGFGYNDCGQLGFDSEKLPKAEKPILMMKNVYRIFSGISSVHVFLLNSNQELFGCGFNGRGQLGLGKNQLKSNELIQIQNIPKGNIIDIQCSNYSSLMLIEEDDDRRKFYLSGSKGEFSKMISDDGKENSMVFNEFRLTLGENETERYLDDELGNDNILDFSVGYNHTLVLTYGGKLFGFGGNTSGQLGSEKTNVYKFITNEIKLPKLRFNEDTSNYHVSCGFNKSFLYYSRYFSNLEEDLIKLFQRKEFCDISFKTINGEIIEAHKLILKYRLKHYEDGIEKLQEIISKKTTKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7V0</accession>
    <name>A0A9Q0R7V0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7V0"/>
    <dbReference type="OMA" id="MEKVICA"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="874" mass="105132" checksum="D465D777B9E98552" modified="2023-09-13" version="1">MKVKQDPAIKIIQKPFNLKKIVEIIKLRKELKKQPEILLQKFRHFNFENKGKDWILFLLEYIYRNDGKEKLNNFIQNGKLKKNDLAKNLIKSYSNSKRLSNNLFKKSTVLNFWIKNNYLTNIPDEIVEESSEEIQMIAQNLGMIDKKVKSKEIIHMILSTTEIFLKINLEPFYSLLKFILETGNTEKEKIEEMREIHWPTTPKATFPEDLIKNLNKIFICENNHINIINKPNEEKLMKCRICDSRIIKNDGIKKSFFKKPFSYTFSKYPNTNPLYSIRELNPIIFRFIRLAIHCFFLPFIIISEKASKNFISILNDLFFQSKNQDDLINSFLEHIENDFEIFTKLLKFSKEESLIYYYQILSNFRSKFKSQKQSVIDFKNIEGRNSFEKIVEDIYQKNNQKILESIFSEQIEKNELIQEIKKSSSEKKWMFISFERNEIFEIIDLMISKNPEERRKSIIHFIIENSNKLKILKLFPKFLTFSSIIFNELNGKIRKEETKIMKINEFLNQENDLDSKTNLQKIYQDFEKFWNLCLKEIKYLIVKESLPQEFEDIKMNENQIIDYCLPGNEPNHLFIEMMINHSIRLNNEMIKKMKELKEIQQNNHEWNHQEKPFLISFPISIEKFNGISILDIDPDKIEKEFKNQFIDKYFLRILEFKINSQIKMNLTNFRDLEINQINQFIYSNPETIIEQYQIPKLEFKDEKLAINEWEQILNDLEKHSQIKNCQELVKQIWQGIQKIDPKNVTDELFEKTVYDYVLNDLQNHEIEEISKSSPNFKSLKKILSIYQQEMTNLFSSFSKNEILELERIWKEFISTFLKDNLDENEKIKKFLIQIEPENEQLNEQIEKNFPESIKLKFCIGAFKYFERNLKTFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R876</accession>
    <name>A0A9Q0R876_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="447"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="515"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="685"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="719"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="753"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="787"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="821"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="855"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="889"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="923"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="957"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1127"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1161"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1446"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1380"/>
            <end position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1545" mass="178675" checksum="13F417876B36FACA" modified="2023-09-13" version="1">MNSNKKLNKVYKAIKTNNLKFFDSIPTLRGSKKIEKENESFIFYALKNNSSNEIIQKLIEKGTNLNCVDYYKNTPLHIALQYKYSKEIIELLISKESNINSKNKQNETPLHIALQYQNSKEIIELLISKGADLNSKNNKNETPLHIALQYQNSNEIIELLISKGADLNSKNICIWDETPLHFALKNKYSNEIIELLIYKGANINSKNYQNETPLHFALKNKYSNEIIELLIYKGANLNSKNNKNETPLHIALKNQYSNEIIELLISKESNLNSKNNKNETSLHIALQNQYSNEIIELLISKGSNINSKNRWNKTPLHIALQNKYSNQIIELLIYKESDINSKNNQNEIPLDIALQNKYSNQIIELLISKGSNINLMHRWNEIPLHIALQNKYPNQIIELLISKESNINPKNNQNEIPLHIALQNKYSNEIIELLISKEADINSKNNQNETPLHIALKNKYSNEIIKLLISKGVDINSKNNQNETPLHIALQNQYSNEIIKLLISKESDINSKNNQNEIPLHIALQNQYSNEIIKLLISKGSDINSKNNQNEIPLHIALQNKCSNQIIELLISKGSDINSKNKQNEMPLHIALQNQYSNQIIELLISKGVDINSKNNQDEIPLHIALQNKYPNQIIKLLISKGVDINSKNNQNEIPLHIALQNKYSNEIIELLISKGSDINSKNNQNEIPLHIALQNKNPNEIIKLLISKGVDINSKNNQNEIPLHIALQNKYSNQIIELLISKDSNLNSKNYWNEIPLHIALQNKNSNQIIELLISKGVDLNSKNNQNEIPLHIALQNKNPNEIIKLLISKGSDINSKNKQNEIPLHIALQNKNSNEIIELLISKGSDINSKNNQNEIPLHIALQNKYSNQIIELLISKESDINSKNNQNEIPLHIALQNKYPKEIIELLISKGSDINSKNNQNETPLHIALQNKYSNQIIELLISKGSDLNSKNNQDEIPLHIALKNKYPNQIIELLISKGSNLNSKNNQNEIPLHFVLKNKYSNQIIKLLIYKGSDLNSKNNQNEIPLHFVLKNKYPKEIIELLISKGSDINLKIDGNEIPLHFALKNKYPNQIIELLISKGSNINSKNNQNEIPLHIALKNKYPNQIIELLIYKGSDINSKNNENQIPLHIALKNKYLKEIIELLISKGSDVNLKNQWNQIPLHIALENKYPNEIIELLICKGSDLNSKNKWNEIPLNIALKNQNSNEIIELLISKGSNINLKSKWDEIPLDIALQNKYSNEIKILLMRDLNIFELEKNRITQEMIDLFPKIYSFNEDLNNFLKSNEFKDIEIKSNDGSIIKVHKQILLIRFNNNPKILTKFINICRRKPKEIIQFALNFLYTGFIDFDKFIEKFNQKFIQKKSQIYSDYKFFFSNEIEFEEQKKEQELILNEIENKNEKYEKILIYDLFKENGFDSKWIKEKEGIRGILKDFGKLYEQNETKDFTIIIEEKEIKVHKLILQIRSELFKGMFLLNTSDSTNQVHDYSEKSFETINQLIYFLYNDKIDETKITKENISEYIDISEYYQLNQNSIFDKFLLNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8N2</accession>
    <name>A0A9Q0R8N2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_10504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8N2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5071232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="377" mass="43215" checksum="51ADEC6A282F25DF" modified="2023-09-13" version="1">MSEEIKPIVIDNGSSLTKAGFAGEESPKSVFPTIVGKKRYLDIIRVGMGEKNYYIGDEANGNRGYLELEFPIEKGIIQNMDYMEKIWHHIFYNELRVSPEQYPVLLTQVPFNPKNQRELTTQIMFETFNVPSFYMANQGILPLYSTGKTTGISVNIGDGVSFTYPVYNSHSLSHCMIKSSFAGKDITNFLIRLLTERGYFFETTPEFQIVNELKEKLCYVSLDFDKELEISNQNDSLILKNFELPNGKILTIGNQLFRCPEALFQPKLIGKEQKGIHQMIFDSIMKCDIHTRKDLFQNIILVGGSTFFPGFLERLQNEMNKLVPPSMKIQFIVPSERKYSVWIGGSIFASLSSFQKKVILKEEYEEYGPGIIHEKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8R4</accession>
    <name>A0A9Q0R8R4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8R4"/>
    <dbReference type="OrthoDB" id="5983325at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="166" mass="19426" checksum="87241B9F97BEA8F4" modified="2023-09-13" version="1">MELGFSAKRDFFDCNKWHSKCDNKGKTLVIIKTKDNFIFGGFTQVGWTTDRSKWKEEEVNNPWGYIIDPKSFIFSLRNDKNDRKSEKFKIKSAQTMHSIFYYSEGGPSFGRGLDICIRSNLKDSYSNFGYSYHLPHGVEYNTKEAKSYLAGSYNHWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8U0</accession>
    <name>A0A9Q0R8U0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8U0"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="316" mass="37222" checksum="930E788C00B3B156" modified="2023-09-13" version="1">MNQILFFGRNKYPRLIENEPEKIKKPIQFKFENENEKQIKQIESSYFSTIFLFENGKAIEYLNDSYQNPEKIQIEENIQKVTVVSRSEAILTKEGNVFENQEKKTIQKLTQIQNIPKGKIIDIQCGYWHSIMLIENPERKLYSCGYYQYNGLGNNQTTYEFTEIKSSLFENDNIIDFSVGNLHTLILTSNPKLIGFGENYYAQLGIGNTYNQSIPIQIELPKLRFNENISNYHVLCRNEKSFLYYSPPSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLKEIISKKSIQRIKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8W4</accession>
    <name>A0A9Q0R8W4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorbin and sh3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8W4"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="232" mass="27904" checksum="B3BCB328E6610858" modified="2023-09-13" version="1">MSHLYAIAIENQKSDSNKQLPFNSGDYIVIIRKLSNDLYEGVCNGIIGIFPESKVNFLNEDQIQKEFFTDLSRTSEINSLNIEENQNFLDDEFAFSDFLKKEKEKMFMIESETFETQENQENQENQIQENQEIEEIEENQIQENQNQEIQENKYQEIEEIEENQNQEIQENQDIEEIQEIEEIQENKYQEIEEIQNQNQNENQNENQDEYQNQNQNEYQDENQDENDNENPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R921</accession>
    <name>A0A9Q0R921_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_10061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R921"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040350271" description="Fibronectin type-III domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="469"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5071652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="903" mass="102302" checksum="DD365BFB0171EE08" modified="2023-09-13" version="1">MESNLFFLFLLFLIINIFLIQSNQNQNQQQKSISTIIQELETTIGTTRYYSTPDEAWIWNLLDQFSDSTGNFGRSVSIYKDVLVIGTQYANKTFIYRYNGSIWNQEQILSEPLVPYFGFSVSIYEDVIVIGAPNANKAFVYRYNGTNWNEEKILNESSASGFGISVSIYENVTVIGDYGAFKTFIYRYNGSIWNQEQNLSEPLVPYFGFSVSIYEDVLVVGTYGANQAFIYRYNGSFWNEEQFLNESALYFGWSVSVYENVTVVGAYYANQAFIYRYNGSIWNQEQNLSEPLVPYFGWSVSIYEDVIVIGAPNANKAFVYRYNGTNWNEEKILNQPSVSQFGSSVSIYGNFTVIGTSGADQAFVYEASLIPQVNILNCSSLFSSFDCYWDKVEFFRTLIYQINYGYDWIDIDSPILEDGNVYYQLFNSSIYNNITGNEYYSIQIKACDNETMKCGESSSFINLTTKIDSVKDFQLSNPSNNSINVTWDYPNVQINEGIAHLNHYNLSYLNQSELDLIYFISVDNSSLSYFLNNLECENDYNISICGCRTHECEGDDKGEIVESSISLIFGEITNFSCLISNSIDINCNWNQPINCSIPSYYNLTYQSIYQNDSGNYRPTSSNQQFTVQFPNQEYQINISSCNSNGKCGYISSISITTDNLTSPIIYETISKIEEIEFNFTKLTNAKNYSISLDNGINWEKFTSLDLIGNEVIGMISGISGNIEYNISIRGCVDLNCETPYLGLPSSIISTRAKLGNITSLNCYSLINGFECNWNSLILSSGLKAYSFTYNSTSICLTNLTTIYSISSGLNEGEYYEISIYSSADLNCLFNQYSGINSTTSITISTINEPNNNSNTTIIVLGIVIPIIVISIIIIGIILYKKKKRKQVIKEIIKEKELHTDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R971</accession>
    <name>A0A9Q0R971_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein kinase tnni3k-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R971"/>
    <dbReference type="OMA" id="WEIVFRE"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="189"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="459" mass="52818" checksum="9EE990B11A5AD723" modified="2023-09-13" version="1">MDEFFEAIWRNDNLAIKKLLDEGYDVNTKNEMDGKTPLHIAVQEGKNEVIKMLLEKGANPNECDVYGATPLKIAVTNSSRNITEILLQNGADVDLADENLETPLHVAVISSNNRIIKLLLEFGANPLLRDSYDEKAIDLAENDSVRKFIEIYTLEFIDYSPSLYFRFVNEYKNETLQNLTDFALDSAKLKEISFIKSGAFGDVWKGEYNGKVVAIKKFPKLQQQNLELFHREVALLCKSNHPNIVQTIAFNINQDQDPDKYPTCIVLEYVPKGNLFDRLKKLKKKKLKLKKSTIVNYAKDIAEGMKYLHSMNIIHRDLKSSNLLITEDNRIKITDFGLARFKSNEDQIDQEMSLNVGTFNWMAPEILRGEANYSSKVDVYNYGLVLWEIVFREVPYKAHLISIQNYDLRNEVGFKRVRPDLPTTEQAPQEIIDLIQRCWDHDPDVRPAFDEVCDILAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R984</accession>
    <name>A0A9Q0R984_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R984"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="479"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="605" mass="70541" checksum="0CAA33F6F0ADC513" modified="2023-09-13" version="1">MNDCLFFGRNQNPKLIKNEPEKITKPIQFKFENENENEKQIKQISTGNYSTIFLFENGKAIEYLNRNDSNKNPEKIQIEENIQKVTVGYQNEAILTIEGNVFAKGNDINSKNSNEFINISSLIEDKNDRIIEDIVSGACSIYLLTSNQNVYGIGLNHWCQLGFDSETLKETEKPILMMKNVSKIFSGNTSYHIFLLNSNQELFGCGYNQSGQLGLGKSIKERTIQKLTKIQNIPKGKIIDIQCGIAHSIMLIENQNPKRKLYSCGDRNYNGLGKYKNAYEFTEIKSSLFENDNILGFSVGCFHTLILTSNSKLIGFGANYYGQLGTGDTKNQLIPIQIELPKLRFNEEISNYHISCGYHKSFLYYSPSFSNLEEDLIKLFKRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQLFEYWIYSNQIKEEIQITKEIINEIQFGIDYFQLNQTNPNLFDLLINKFNNQNQNLTKQKEKEKEKEKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9D2</accession>
    <name>A0A9Q0R9D2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9D2"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="545" mass="63775" checksum="462C43FE827B6107" modified="2023-09-13" version="1">MLNAILFTVDSISRGNQLVFRFPPPQTQSTVHSSLQIPFSNLEAQTRHEFLPCEETVFQYSQDFLANLLCPDKSQLENIFELSVNNLLFIGFPLSLSVKKKNRFGSFKKFSSFNFQKQNSQTDSTLNDYFQQSNNLFSNSIIEEDNPKYVENTQEEITMFHIVFAACKLHCSQEKFPEIHHDKKIVTSNSDYLQQFIDSISLVAKQVSNAFHYLEKHSKYISTQVETIFEIIDTHKKSTQLEDEISLIKVILEKSSLARELRQIYHDLTGSLRQTTEVIINNWLRLSLSLRNPNMELFPGFHFTAFKTLLLLDTKSKLRRDLPHGSSPLLLRLINNLDPTKNFLELEIITKIPRNQLFRLSAHLVFWKKARIISPITSESIYSPAPNSNLKMKQYEDSFSNFFKHKIRLPEILEMISTFKEIGKYKIRTDVNIIDILIWLLRNNLAIQIEKTIFFKYNKDDKSELSHEEQIQYYLSTLNPEDEKTKLFQKLAPFLNGLFPLTEILKIVELTSESINPFLKYFEDVIFVIYKLPESYPKEQQINFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9K2</accession>
    <name>A0A9Q0R9K2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exported protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5071981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9K2"/>
    <dbReference type="OrthoDB" id="10265253at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39201">
        <property type="entry name" value="EXPORTED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39201:SF1">
        <property type="entry name" value="FLAVODOXIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="186" mass="21450" checksum="3B03083FC71CE31C" modified="2023-09-13" version="1">MISAKPVKISSNLIRFFSTNKEKILIVFHSRSGNTKKIAQEIQNKFKKEFETDLEEIKTEKRYSKLGIIFAAGKDAMTKKLTNIAPPQKDVSQYSTVVVGTPIWAWTITPAVRTYLESQKKKFKKTAFFCTFGSSGDQGTFQEMKKILNLDPISTLPITRKELRNKSYEQKMEKFIEKIKLNLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA27</accession>
    <name>A0A9Q0RA27_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="DNNSRED"/>
    <dbReference type="OrthoDB" id="372958at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="938"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1537" mass="183959" checksum="62D5E8EEC114418D" modified="2023-09-13" version="1">MNQNFEQQQEQDKTENNQDKDNIQQDNIEQDKDNIEQDKDNIQQDKDNIEQDNIENDNIQQDKDNIEQNNIEQDNIEQNNIGHDKDNIEQDKDNIEQDKDNIQQDKDNIEQNNIEHDNDNIEQDNIEQDKDNIEHDNIEQDNIGQDNIGHDNIEKDKDNIEQDNIEQNNDNIQQDNIEQNKDNIEQDKDNIEQDKDNIQQDKDNIQQDNIQQDKDNIGHDNIQQDKDNIEQDNIEQDNIEQNKDNIQQDKDNIEKDKDNIEQDKDNIQQDNIEQDNIEQNKDNIEQDNIEQNNIGHDKDNIENDNIEQNKDNIQQDKDNIEQDNIQQDNDNIQQNNIEKDNIEQGKDNIEQDNIEQNKDNIENDNIQQDKDNIEQNNIEQDNIEQNNIGHDKDNIENDNIEQNNIEKDKDNIQQDNIEQDNIQQDNIEQDNIEQDNIQQDNIGQDNIGHDNIEKDKDNIEQDNIEQNNDNIQQDNIEQNKDNIEQDKDNIEQDKDNIQQDKDNIQQNNIEKDNIEQGKDNIEQDNIEQNNDNIQQDNIEQNKDNIEQDKDNIEQDKDNIQQDKDNIQQNNIEKDNIEQDNIQQNNIENDNIEQEQDKTENNQEKDNIEQDNIEQDNIGQDNIEQNKDNIEQDKDNIEQNKDNIQQDKDNIEQEQDKTENNQEKDNIEQNKNNIQQNKNNIEHDNIEQNKDNIQQDKGNIEQDNIQQDNIEQDKDNIEQDNIQQDNIQQDNIQQNDKDNIDKDNIEQNKDNIQQDNIEQNKDNIQQDNDNIEQDKDNIQQDKNNIQQNNDNIEQNNIENDNIQQDKIEQNNDNIQQDNIEQNKDNIEQDKDNIEHDKDNIQQDNIEQNKDNIEQDKDNIQQDKDNIEHDNIEQNKDNIEHDNIEHDNIEQDKDNIEQNKDNIEQDNIEQNKDNIQQDNIEQDNIEKDNIEHYNIEQDNIEKDNIQQDNIEQDKDNIQQDNIQQDNIEHDNDNIQQDNIEQNKDNIQQDKDNIEQDKDNIQQDKDNIEQDNIEQDNIQQDNIQQDNDNIEQNNDNIEQDNIEQNKDNIEQDNIEQNNIEQNKDNIEQDNIEQNNIEQNNDNIEQDNIEQNNDNIQQDKDNIQQNNIEQNNDNIEQDKDNIEHDNIEHDSDNIQQDKDNIEHDNIEHDSDNIQQNNIQQNNDNIQQDNDNIQKESIEEYNIEQNENDKQKYTIHQDQNTVEPDESQQQIEFNLDESGFNDFQNFTENMQFEEFSSFEQISHQEFETQQVNSQIENQIENQIENQIENQNENQIENQNENQNENENENQNDQFQTSFFDENQENQNENENEQIETTFKPFEDSTIKFTEYNENENENDFNPDFSEFNEFQDFSGFQQNFDDFPPLNEETLQNQFENENQNEIENKNEIENQNEFENENQNQNQNQFENQNQNQIEKENEIPKEIYQIQTNLYQQTNLSLIQNQILKIFNKNQEKKKKLEILSSFTNEIKWNQNTLTNNYNFDKNDLNQILLFSQDLFQKVINQQNQVENSNENVLDNKFDKISEQFLSSIPDLGFMNLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA86</accession>
    <name>A0A9Q0RA86_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA86"/>
    <dbReference type="OMA" id="VMWISWI"/>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="438"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5072731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="626" mass="72779" checksum="DA9AD72B3CE8DE14" modified="2023-09-13" version="1">MNENTNQNINLNENINLNQNENTNQNENINTNQNENININQNINQNRYYQMEKLHVLSEATKHGNFKLVKEIIESGFDVNTLDSRNATALHWCAAKDSFHIAKILISKGANINTPGGPRKQSPLIWAVVSQAIMFSQVLVNNHANLYQKDSIGLSPIHHSGRHKRLLMCHYLIERGVPYDLLDDSGRTTLHHACGSGSVEIIRYLISLGSSPNTIDSFGRTPLHYAVISGNLEAVKILVQHGAKINIEDKSQKTPIQIAREKRMFYISEFLESVKKELQILQNPFIRSHLKILFGFFPLFTFLIMNLIFSNFPFALSLFSIPLIIYLFLKIGKKYPSKIKGQSPIVFGTVTAMYLIDYLTYFFQVLPTTIKIYPKSTILFIFPNVIMMWMFSILILKDPGFIQQKPLNIEKKITEEIEKNEKRMKKKPETKPKVSISDGNFCATCQSLKPLRSKHDAKSNRCVAKFDHFCPWTLNVVGDKNHIIFIIYEIAMPITQLIFIFFSYLFASSNPEIPKLTFSSIPSFISSIYHYYPWLLSVCLQTLFYFSWEINILYYQIFNILHNITTNERINLKRYQFFWKDGIFLNPFDLGKQNNLLQFFKLKYRVDWYSIFRFEDLPYFNPLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAW0</accession>
    <name>A0A9Q0RAW0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inhibitory regulator protein ira1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="CHEGEME"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1054"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1299"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1299"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1388"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1459"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1672" mass="193402" checksum="951CBD935E938449" modified="2023-09-13" version="1">MFTEYFEKLIRRVSHINYIQIFNQVIEAFTKIKSGNEDVQIRKLNLIKYLDYDNIKLSELFRVFKSIFYLFPKNHTKLISEVLKRIWNWINHRPSQFTELSQSKKTMEGNPDTLFDYFQKHGQELKKESHLFWPTETMLLILCPDILISLTMGDKQALSSSKGIFFNELQSSLKLKGEISDMAARCLVDFCQASTYVSKADISGLRYLVPIIRPDLNKKLLDQSKPYQDLEIIAQYLIASFKINPRDSFDNCKDENAPLSLKYSLTKALRIISQEEPLPWNPTISGAYSIASFIKNLFKENIANIREIQSNQLNLGKPKNISNLLNSPTIKKKEKEQLIIAQLRIDSINEIIKLFSFDPSFFLYYPFDENQDQNIQFKKMKTEAKQMFKLLTSFLDDSFSNEITYSANLAIRNLFIPEYIVKWCPDDIIRGFYEIGSIIFFSIGNLIVESIEISQEHTNLLLDLLHYLLRKRNEFLLANQSFSFSQIPENVIRQHFNSNTQIEIALLILLCNSDPNVCSQAAQCFDFLCEEVKIIGNLEHSNNTIGALYNEYKQLSQLGQLKTGRIAQQKAIHSLFRRIDIATFGNMPAWKKIYERWEYATNIITSNLESTINENISKIKSKQKGSTQTTSSKEFSDADLNRTKIEWNNYTGFLCSLAAVAKKIPESSKESQQKGKMMVDSFIEKVLDLIICDVDYIKEIIIQTISCISPAVYHLLFEKIVEKINNNIMKDGNVISSEKATLFIDQVISLIKQILDQPFELDDFSTIDLESLVISIVHYLSYITVDSKTLRIKCKLCQLVELMIKRRGSLLFRNETKFRNELVEKIMEWFSIYQDGSDSNKDKTSNNSMNEINQINSNILSQQTNDENKKISSKLQFYSKDSLEYNTELSRMKRELDITAMRVVETLLEKLVLQKYRAVEVKQQQTGDEILEQKSKLFSQYFLFFSTMLSRLQKKKLLDEDAKKLYQHTTMAVSNMIHSNVSVGLRHALPMGYSADIESRASFLEVLTIILKQGTEFGSLKETVQDKYKNIIDMILSDDLVVTKAIFSITKVTESDLISKLLVRINEYNGTAIRLLKWSIQDEVIGTPQDQPQMLFRRNSFASKMLGVYSNMVGLEYLKNLLSDLVKNLTNELTINHKTIEINKALLKEGEDINSNLVNLQNFTQQFLDKILNSVEMIPKPILYLSSYLSSSVGERFPEYIRITVAGFFFLRFLCPVIISPDNFDIVSDRISPDVRRALILITKTIQNLANNVLFGKKEEYMIPLNTFIESNKEKIEDFITKITQLSINEKVEKIENNSNVMNDSIQKTEQPQVKSPTKQRMSPINLDENENENENEKSPKITTRPRFPRGRIPRTKTENETEQQETKRQDNIQSRIPRARSRNAQLSSRTTSIISTGISPRATRTSRTTTRTGFQRASPRSRLPPKTTSPPRTKSPQRTTSPQRTTSPKLPPKPKSPDQISKNENQNQISKNENQDQISKNQKDDKDKSLLSSSIQISKEEISQDFSTIHSFLYSNIEELSLYFQHQKEQNVSKIGEKFLSILNELGKPQKQENDKQKSSPNLLSNVSLTESSTLSENTKRNRKFKRIYESNERKNTSRFENVFQEGKSKRRTCFYFIPRRIQQSDDMGILVYHIFKNFESYFAKETQPFIVVVDGTMFSSQHEIPKTWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC70</accession>
    <name>A0A9Q0RC70_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC70"/>
    <dbReference type="OrthoDB" id="18783at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="350" mass="39246" checksum="16557CBCAC055490" modified="2023-09-13" version="1">MIQFLLISYSPQNVLQYSLLMSKKMFGEIAVNYHMDLNLSTINPNQVLFDSTADSFGNIILIASDESSKFEMFLWNNMSNTLDLITTDSFNSSQNLQKSSFAFVKDSDFIVQIFTDDLNDLNIQLWSFEFNQNIFRIDQIGDPINILENIANDVFDDFTIAAIQDPGDDQFIHFLTSFSVQQKINATIGTISKTGELIKITPSTTVTFGSSPKFSVISFQSQIFVVLTNENGTCHQNEHKNKDANIQLCDQEPEPTVNLLNYASGLLETWREYLTGETNILNVCGDQIIVGEYDMGKNSISELILDQENNDIIFIEIHDGLTESIDSNCGAASSYSGVILDGFRIPFANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDB7</accession>
    <name>A0A9Q0RDB7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_06816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDB7"/>
    <dbReference type="OMA" id="APYWTTY"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="68"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="463" mass="53266" checksum="97E38EBD5E86EC8F" modified="2023-09-13" version="1">MNLNEKLNEKVNEKLNEKLNEKLNENEKEIKTIFNTKNWVKNHIQKIKMSSTLEMNMKMKKLEDQGKKVYKFGFGQSPFPIPEKMIENIKENVHENAYPPVEGIKELRQTIAKFESIQKKQDPTFYSENNVIIGTGSKINMFNLMTIANCTVIVVTPAWVSYAKHTEILDLPIEYIHTSFEDNYKLKPQILQEKLSKINGNALLVINSPNNPTGLSYSKQEIEELSVVLKKHPVIVLADEIYSLLSFDNDYHSIAEFCPERTIISSGISKTFGAGGWRLGYFVFPEELTFLIQPMKIITSHTFSAANLPVQFTTKFAYSNFEQFQEEINKSIIILRSIANFGYKTFTKAKIRTIFPNGGFYFYIDFENFRTSLESNNIKDCDSLCEHILQDANVALLAANSFDRDINELAARLAFVNFDGKLVLDNFSYEYVQKDGFLSDSFLREFCSETIEGFEKLADWVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REP9</accession>
    <name>A0A9Q0REP9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Microtubule-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REP9"/>
    <dbReference type="OrthoDB" id="17995at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="884" mass="102212" checksum="FD94F2C3ADA9DF4B" modified="2023-09-13" version="1">MSFNFNTDQLTDMCDDVMDEMVEMDQIEDVLYNNLTDMCDEIIDNFDDDELLRELEELEKSEKSSNYLSFTPRPLDIPFSIIKILTEKSKTIINDKWKSNVKLTTRNLLKILSQMKNSNPQLKFIVYNAVYNGLAYKKHSLFNSTIYISVLKVPINGFITIPLFDKNISIVESDIQLLENGKQLVSKEEQQGFSNIEVGESSYNFITNQAGNFEVGIEYLVPYSTERGKELNFRIPISIKNELIYSIPSDQKVKVFCSEAIDNSNQRWEEKKEMENVDNKIEGKGLTTLKSNFLSQNKLSISWIEPQKMEFSESESESESESDQENKIEEEKKEGEEKEEKKEMITNVEQNVLHSIGEGVVLTIAEFNYEISNGAKSYLEIAIPNIGSKPKFKILNLKGHSIKKWEVSSRKEEDENDENDENDENDENDENNENNENNENNENDENDENNENNENNENNENIENDENDENIIQKKQILKIWLECSVENNYHLILETELEMKSTSCDVVLPVFECMGKINRETGFVAVEARTNVEINECEITNLIKISTYEIYDKFYQFSRGGSLLYAYKFLIPEFDIVLKVTKHKDAKVLISIIETAHIKVLYSENGEVLYTCKLKVRNTQNQFLRVLMEEKTSEKEKENDEDEDEDSKSSDCELWSTLVDGKSVKPAIDKNSLILVPLKKSDSSNPDQPPFDIEFVFIKHHQSPLKKSGKLFISTPIFDLPINYLCITLYVPKNYKFSEFVGDLIEINSFSKNPNTEIQEPQSKRKSSSSIINQLSKMGGKGKQKQNQKQKMNFLKKKVAPISQKGLNFGQNFNSNYRGFLEQESFDEIYDLVDQDVTKQQYKEKEKVAGVLAVHISDIYTQKQFLFEKLFVLKKSLKLFANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REU5</accession>
    <name>A0A9Q0REU5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REU5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="135" mass="15282" checksum="3C25EB512AAE6C16" modified="2023-09-13" version="1">MKRKLQQKNQKVVEVRRVKNLKKNTSRKDESAVLQHVCLMITATPQSWKVVKASFIRMWTLETLHDQICTQDGLNKISQLQNTQNSIAQIYGFVCSINVNLLLDTKLRTALLHTDCKSGALILNVSCVLLVLSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF81</accession>
    <name>A0A9Q0RF81_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear localization sequence-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF81"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="621"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="555"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="765" mass="93856" checksum="456BA1C3AE579A2F" modified="2023-09-13" version="1">MFYQKQVQDNSIFPDLHSYTQKGQEIPTIDKHLPSFEYSRQFMNSSFQNPFENSISKRITDKDSIHQFSQNNQISNRITDIEQSQFPNNSIFKRKILEKEPISKRITDMEPIHQFPNNSSLLSDPSFLNDSSFLNDSSFLSDPNFPNNSNFPNNLNFPISKRITDMDSFVRLPSQNNHSSRHLSDVDSVIPYSPYYNNNNNDKNTFQNYGNHKDYQYNKDRQDYQDHQNDKDYSHYKDYRNDKNYRNDKNYRNDKNYKNDKNYKNYRNDKNYRNDKNYKNYKNYRNDKNYKNDKNYKNYRIVKSYDNYANDKNQKNYKNYRNNKNFRIVKSYDNYSDDGNYRDNRNFKKYNNYKYDKDYKHEKDYKHDKDDKDYKYDKDDKDYKYDKDDKDYKYDKNDKDYKYEKDYKNDKDYKYDKDYQNEKDYQNDKDYQNDKDYKNDKDYKNDKDYKNDKDYQNDKDYQNDKDYQNDKDYGKDKDYNHDKDYGKDEKTIPDLEPIIEYSDQNNISDNKSKEKENQNEIPNQNQIEIENQNQNQNQIENQNESQNQIENQNENEIENENQNENENENENRNKDQNEYSQEYENKRPRKFFDLPPRHYYKSYLNREKKTMRFGKETRPTRSLFIGNLSFSVTDNFLYKLFSTIGEVDNAVVGFDKKTGRSKGYGFVSFYDVNDAKKAFEYFENYRIDQRRIRIDWDPGLDKKVFPSDPYDHTGSKLSKNNYYRNRHRNKYEDEYYSKRRKEDLDNKTKYDSVIEISKEEKEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFB6</accession>
    <name>A0A9Q0RFB6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sorting nexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFB6"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="512"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="781" mass="92658" checksum="2565EBCD9F682A8D" modified="2023-09-13" version="1">MSIEFSIKISIFFLGIKRNKTKETPKQEEKQKQNKNKNQKSTQLIDIDLGFDFGDSNSKKEQKEKEQEKELELEKEKEKQKQKEKEKQKEKEKEKEKQKQKQKQLTKQKQKELELQKQKELELQKQKEKEKQKEKQKQKQKELELEKQKQKQKQKELELELQKQKELELQKQKQKELELQKQKELELQKQKQKQKKKPKPIPKPIPKQKVINKKIPSETSSETSSETDTETETETDTDTYTSETNSGTYTYTSEIDSSEIEILDTEKYTKTKKKVESKKKVESKNKVESKINKSKSKQIDKDKNETQEKPHRKHTSHHKNEKEKESTQKSKESKKRRIKRRRKEELKRRIKRSTKRRKIQFQNKICKTKNNINETKKETEKEVIEKDTKREKNHVEKPTEKNEPQKKLTLEQETSLKKVMEQSKTISVPRRARGIKGRRRPSKKKLENIQTIQITQDAKKEINTSNDQTKQHQKSRIPKENYRNQTGNKEEKKAENLLVSQSIIPPEKIPSPFTQIHVSLPQLVGTGRKKSVSFEVSFSANLSESQIMINRKFEDFLWLRKSLTEEVPNFIIPVPVEKSMIKKMDPESSEILRRALERFLLRISYHPVLGNSASFHLFFETDDSSIIQTQTLFDEDYLNIKTQELNILEKNAQILSRTISNKSLLGFLYHNLKSHFSVFLAQHKLEKQIWNNQLRKFFSKFQVVNPQLITSKNPNLRSKDKKISKAKTEVGKISQQGIPSKEEKCKYQGKRGSRFFTCKDLVLHHKNLHTYKLFKMKLIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG76</accession>
    <name>A0A9Q0RG76_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1728" mass="205293" checksum="1C7F606A305FF90B" modified="2023-09-13" version="1">MNKNKFYIWLVIKNHTIENLKKFQVKLLIDSSDKEEEIKLKKPSLSKNIWFAKFEREAKKNEDKHLLKFHFQIEQNIKSTQYIIEKNEFKSVFIEFFEFVSLNRNPKYFQNESVLKLLDSMIFLSKEFSYQKIPQISTFISSLINQKTPDNERLRKWILKKSKKLNSKKSNSNSKSKSKSKSKSKLEKSEKSKMQNFLLLSILDYIYDSTIATNLLFPENDLQEQIIVFAKILMEVLEDKSQINEEIQIKIKNVFEKYLLNLNDLKKEIILYSFILIHLEIQFSFVELLHSNKISKNYFFELLDIGLSSKELVHFINPTLFAFLFGSDYFKDKFWLDILLELFQSHEDLLTKFFRAFNGNAVYTFQLFRNSSFEDPLSFFTFWNAFYLRFRKISTQKNTDNQNENIFVDPYLSLNFDSNSPVNIQDEIIESFFNQKFIDLSNPLSNLKILCESQGVMDKIKESPQEMFEKLEIFLKTWYHKIRKESLIENTEIIKQIDFLKIQCPEWENYILIDVHSMQNTKTNIVELIPEFKKGDQNIIYRLSLGFKWLKIYKESFPEFNNKKHALTKLLGKYSQQILDFGNRIHSSEASYQEFVHLNKYRGDFTILFDVVLSQKLVFKEVNTKYLQVSFNMDLLKTFDNFYLREDSEHFGNIKSQIQQIQETKEPLHKMQEIFKKSQINFSFLRWIHSLQNSNIFQNLWNSTLKPFMKENLDINEFQNKFIPKICEEWAQLYNSIESEEITFSALGDLFPIDKDGNWIDKEIKFFSPEYQHQNPQAREKIDEKIRSFLEFRKQKLDIISFRKFCSFYTFKSSKDGLAKDISIDWKNSTLKKIKQISDNLKSTIPSFDSIPLSFFGELIPANYPKEISTKKLFSKIELNTTLIDWLRTNKKSSHFNPDIFEDQRDKVTAQYLLVLQERMQKYIYKTEFSSFKEFVKLIAKEEKKWQTKKQDISFSLIHKLLPEISGLLSSQSDSSQMRAKSNVVKIFNPETKFFFRSESQKSQVFICEVDNLKFSFNDFEDLYAVFYNYQVPNDEKEQRAETNQAILAFLDFFELIQKSIDLLWELILNFHFEYKFNFFKMFVYGSKEIFQNFLSQFHNQLILDLKEWKKNIQEVFNTMGYLSFFSTEQTLHILHALKSHSLSKSTPKKKEQEQEQEQILLKLLGLYSHKISFETIASKLKNKITQFQGYAKTLNSILQKSFEKQRVIEIPRELLDTSQNFQDMQKLLISNFNRKSGKVADPKIFMCHITQEIKIYDYVSSFFFLFSYHFPLREQVLICEKETTEEDILHFLKVYELYNTNKNLVTNSVTHPSLFVVVHADQLSKKNQNIFISNINSISFETQFPMAIFCSGPKSLFKNLYHAFHSGFINEIGKICINKDQLQKFVSKNTSTSRMKVFTSQLAGSGKTFQIRKFCYEQNQNSQESSYHQILITSENRNEIITKLNSICRKQKPTTKYYIHVELPYFTQSKISDYLWTLLMWGSIENKHAFSLDNSAWNLSENVTLVFEIPSHRFEAPSNESLNETLMFFPPLRYLPENICKVRGKIVSFDRYIPRNGSISKERDEDLIGVVNLFRLYDEKFQSLNKESDERRMVFSIFQEGKDTLFLYQKSKSILQANSKQQLTFRLLSNFWEILKSHIKGFMTYTLIIPSISAEVFGNNLNGELFRTQFIDAYIKSVVNMVERSFDWTSSQIRSDSNEVEMEDMCNTFKQMVPWDSRQLFYYYPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L581</accession>
    <name>A0A9Q0L581_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_13538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000141">
        <property type="protein sequence ID" value="KAJ5066512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="1209"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1641"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1687"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="691"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1074"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1076"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1116"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1847" mass="214973" checksum="437A5D7715B9443C" modified="2023-09-13" version="1">MVNSSGFSMISYLLKKIHPKHIPSKIFIPIQKLISESANKKLQKHLLFNLLMDFDLWIYCPLSIQKTILSIFSKKILYIRKEEDVDLSVRHLFDLMRNYYWIEPAKYSRGKEKKIETINGTALGQRPKKEDILEIREQLLRLAEMLMSCVVEFKSLGQNFKFLVVSLFIEEEKEFSLKILKMIQRLMSKNREKYVDVLQEVDFMDIFILSMDTEDEKIREESLRIVKMLDELSVEMEQYSGLKKKRKLISRVSDRIGYHLIHRILKKYKLTKEIAECLETLIRREIPSKSKFGKKEERRRLKFENFQIFSTLFRLIGTSLNSLGSEVAERLRLMILQSPQSKEKIIEYFEWQRWVIELIEMKIKLKIKIKIKIKLKIKIKIKIKIKIKLKIKNQNQNQNQIENEIENNENQNKSLFVNQIGEIAVNIIKELHIYALLIMKDGWKHVERTVWFVKVFYFPKKIAFQQLLLFQIFDDIIDGLSGIFQKKNQRKSRQTELSDTFIENLFHLLVLVDSFLNDGDKHLMVQPKEEREVQDELHDISTEKDGEQEKQWFRINEQSDEETTKKKIGNDEWRFFLLSKKIIGFLDLINFFDKNGVSFGDKSSSATAAEIVVVLMLNLVRMNVGIDEEIYHLDLLMKFLVGPLQLVSLSEKVRHLAVFVFSIIFTFYTKETNDLTTNELKNLPRIDVSDHLRDRNPQNKFSVETEEKRTAEVDSQSSGQKQQQSKNQQAQRQTHRELCVRRAGMYLSYLHFLVLKTKNFVLEYPQKQLRTLAVQKEMQTLRAQNLGAEDIVELFAHPNWKFALIKCFETECGKIAVEQMGRQMTYQERVQRATSGLKEQYQADHLERKKTSDRIKKNAQKTISLLVSRERERRGIKDSTWTYKQVDVAQRCRSILHGIVHGRGLWSRDQESSTDIHWQLDSREMFLRMRNRMKQNFNFNNHKEASLRRDLGGPIAETEMRIETQIKLAQQAKRSLSTIERALESPDVLDADQNPKQIRETPLNEVENSKITIKSDHEKIFIDSDFDHEDSVKNAVIFSSKCVFVKPLFKEEGILEITSRTISFLIKNQEEENLEENLNSNQNSNQNSNQNLNQSSKQNSNQNLNQNLKENLNQNLNQNSNQNLNQNSNQNSNQNSKEKGKSRVWQASSVVAIFPRRFLHQRTAIEIFFSTRKTIMINFPTIEIRKKAQRRLRAIEPEKLTGSSSYYAQQIRNLKAVADRTRKWRRREITNFEYLMDLNTLAGRTYKDLSQYPVFPWVLADYESEELDLKKPQTFRDLSRPVGALDETRWVGLQKKFSAFPEDMAPFHHGSHYSNPGIVLWFLLRLEPFTTLAVKFQDDKFDKPDRLFSSIQLAWMNCNKNPADVKELIPEMFYLPEMLRNENCFDLGIQQNKIQVGDVELPPWASTPEIFVRKHREALESDYVSENLHHWIDLIFGVRQQGSLAVESLNVFHSLTYSDLVDFGTIPENDLASVYAQIENYGQTPKQLFRKPHLQRRTRVQIAFENFVWSSNWIKNDLQHLYVQLSTDPLLFLHLIELGKSLAFLGSYNKLIVFDAAMKFRLFDCIPNTSPTSPFPFSFDVDTTTTKHQRAHLPLRRHANLRRFPNFFTLAPDAQSFICCGFWDNSFKIINIDTSRTEQSITTHKSPVTCVALAGDILATGSMDTTVALWEFDSHRGRVSTSPIHILHGHNDSIVSLDLSIIFDLVVTGSSDGTCMFFSLTEGKHIRTLSVAKKNTPVSLVKISVAGIIVVYSESNCNLSAFSINGHLLASLDSPHDISSIVLLKNSPFLVCSTFSGFVQFRSLHDLTLVRSFDAKSPVVSLALSLNETFVLAGTQDGRLFFGFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5C1</accession>
    <name>A0A9Q0L5C1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_13677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5C1"/>
    <dbReference type="OMA" id="RHGASQM"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="216" mass="24918" checksum="C6A1F705121BC336" modified="2023-09-13" version="1">MSRRQQNPDIKISKTLSYLLRHGAKKEKIKMRTDGFVLVSDLLEHRSLKRITFEDIKRIVENNDKKRFLLSKDENQNDIIKATQGHTIEVKDLSLTKITKENLPQCAVHGTNRKNWNIIKNQGLSKMKRNHIHFAPKEPGKGQVISGMRTSSEIMIFVDLEKALEDGIQFFQSENEVILSEGIDGIIPPKYFSKVVDSKTQKIIFSSNENEKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5N0</accession>
    <name>A0A9Q0L5N0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5N0"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040493792" description="Right handed beta helix domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53832" checksum="C51104FEE4ED7E77" modified="2023-09-13" version="1">MNKILIFAFFFILVNSTVIYVSNSGSDSTGNGSISNPYQTINFAINKSTNYDHIQIDKGEYQELINLNKMVLLSGSSYYETKVIGGVVFNQSSIIWTGIVLQNLIFENTSYMWTIQTAMTFSNVEFRNVQFKLNGNLTTKNALFHFGGYITATGSEGFTMDNIYFYTGTYENPEGAVFGFRISGGPVTVTGSKVEGYSPTNQSAQVNFCCHFNNLTIKNSETNNGGNFYVSLVTDLYVQDNIFNGGPIAICACHDAYINNNLFNNSGDYPIYGPGPDPFSEHTGGIGIIGVDFDNPTTQNVYIYKNLFAGRVRSASVLVNRWTDPPTPDTFSNVVVYQNDFSQIDDYPTSMVIDIAFPGAIIDAKRNYWGSYYGPTTCSVGDLNCSFTSTKPLRVRGNVYVSPWYCDSNMQTETTSGEDCLYLPSSSSQENSSIVVALSVSLPLAFILVVVILIFIYRKRKVYRIRKEIFKSYESSEWSSVLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5U9</accession>
    <name>A0A9Q0L5U9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helicase and polymerase-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5U9"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057220">
        <property type="entry name" value="DUF7898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25453">
        <property type="entry name" value="DUF7898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hint" evidence="6">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Hint" evidence="7">
        <location>
            <begin position="173"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Hint" evidence="6">
        <location>
            <begin position="521"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1079" mass="125873" checksum="3A8CFAACA3E0AAE0" modified="2023-09-13" version="1">MGIRNYSQNKLIEPKKMIIKNESLLINHQKFFLKGLFNSTSFKSKNNIGIFKRRNLQIIKQIKGLILTCFGTDSGIFVDYGYKKQIYNLLMKEYLKKQKLFKLKIFFNLFTQNMGKNSLQFFVSIFKDWEQKTKFEMREFLVKGLTKKEKVYDIEVDLDHNYIINQENLIIAHNCIHEETRVKMSNQKEIFKKAKDIQIGDYVAGIDNNGVVSRGRVKRIFHRTGNARKITFSNGDKLIFSNHPIWMFDKRWENSDNLKIGDKIALITNFNKMETNYSFKEKIISLTNSNEKQNSEHFYDQKRISKKENLPQDDLFYFLIPFICGLFFICGKIVKKGSEKIIKIKIKIKIRHEKQRKESQKLFANILKLLQIKYTKKVEKNKIEFKIISETLSFIIQEFILHNDKKKMNEFFFVSSEEQMKFILGIFSGCNYTKNKSNLLNFSFGKDEEMRNSVCDILLLIGINFSKRKQQNLYSIELSKLSKYKIETIKDQLKKVILKIKNEKHQNAFSTNSIQEILKMKEKKNFVNVIKIREMEKQPLINYQVDVIETFICERIATHNCGRAGRVGIDTEGESILIAPKKQEEIDNIFQVLVNSPLPPLESTFTLNESKGLRRILIECVSSGLIRTKYDAERLMQSTLCNFFEEKKQKGKMEELLVNSLNYLKENGFIQNNEDEDIYQISDLGQGVVDSCLDLNDSLVLYQELLKAKEGLILDSELHALYYIVPISHNIPVNWQIYEEVYCRMNRGLKKVADLLGVSEGYIFRVTSRIIDPQNDTVDEIARIHRKFFVALLLFDLIQETPLPIVSEKYGVDRGEIQSLMNSAGSFSFQVATFCEKIGFHLLHPIMISISERVNFGVKGEIVNLTQIPYVKPYRARKLYQAGYVSIEDVAKAKVEDIEKLIKINKPMVPSGKFELDNNQEYDQEQEDIQKRIQRKIAFKIVYGARALLKQKQATLISGLDISQDENERNLKQKSMSLLQSQLFSQRFENEKDESKEPLSIHTDSTSYSYSYSSSHKSDNFENDLYNSKNENFSIYPQTESKNSFGFNGNGVFGDFGGEYVDILDNLRNEFNFDDYDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6I9</accession>
    <name>A0A9Q0L6I9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6I9"/>
    <dbReference type="OMA" id="AHIAQNI"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="92"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="183"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="264"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="307"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="350"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="393"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="469" mass="50925" checksum="57AFBF3FFC767A3F" modified="2023-09-13" version="1">MTTTLESLKSIVSGIDAAQGTPQVLVNHFITLNNLAMEDKNQPLIRQSGAIEAIIKTLKNNAENNNILEKGIGALGNISVDDTNALEIGKLGGITVVIQTMKDHQVYLTLQEKCCAAIWNLSFQDENKVLIAKEGGIRVLLNLLRYHKDKPQILAKGFGAMLTLALHDSISSIVAKEGGVVLIINLMKQHQSNLDIQEKGLSALFNLAANDVNGILIGRGGGIDLVVSLIENNMDKQQLLNRCIGLISNLSVNNENSKLIGSKGGLVAVLSVMQKYSNNTQILQRCLSALHNLAMLEQNRLTIGQNDGVLVILQVMKANPLEPSIQERVLGVLLTLALDAENQVSIAQNGGIELLIQAMKNFPSNFRVLERVVSVISNLSFDETARRLVGEKGAIQSVIELLKSNTHQETFVDKACGCLMNMSCDNDNRQIISRLDGVQILSNILKLYPSNPNIQKRASGAISNLGSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7K6</accession>
    <name>A0A9Q0L7K6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7K6"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="177"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="333"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="437"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="542" mass="63105" checksum="077D422B7EA27353" modified="2023-09-13" version="1">MNDCLFFGENEYQTLIKNEPEKIIKPIQFKFENENENENENENENENEKQIKQISSENIQKVTFGCRNGAILTTEGNVFAKGKNINQNNPKEFINISSLIEDKNDRIIQDIVSGVSSIYLLTSNQNVYGIGGNYSSQLGFDSKTLEITEKPILMMKNVSKIFSGTDSYHVFLLNSNQELFVCGNNNSGQVGLGESRKYETKIHKLTKIQNIPKGKIIDIQYENTYEFTEIKSSLFENDDYILEISCGAGHTLILTSNSKLIGFGNNSFGQLGTGYTKDKIPFQIELPKLRFNEDIYNYHLSCGENNSFLYYSPFSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNENQNQNQNQNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETIKRIYLNENENGKDFIIERKENQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQILEYWIYSNQIKDDIQITQEIIDEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7R5</accession>
    <name>A0A9Q0L7R5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7R5"/>
    <dbReference type="OrthoDB" id="70707at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="296"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="42179" checksum="E9A534D8C67FC54B" modified="2023-09-13" version="1">MNEIIFFGWNQYPILIKNKPDEITKPIQFKFENENENENENENKNEKQIKQIVTGGFATIFLFENGKAIEYLNENDSYQNPEKIQIEENIQKKNPKEFINISSLIEDTNDRIIQDIVSGYQSIYLLTSNQNAYGIGLNQYDQLGFDSETLEKTKKPILMMKNVSKILSGNYSSCVFLLNSNQELFGCGYNVYGQIGLGESRKEIKIQKLTQIQNIPKGKIIDIQCGYFHSIMLIENENENGKRKLYSCGNYLYNGLGKNKNTYEFTEIKSSLFEENDNFIDFSVGDEHNLILTSKGKVIGFGNNLYGQLGTEDTNYQSIPIQIELPKLRFNEEISNYHISCGDNRSFLYYSPPPFSNLEEDLIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8B3</accession>
    <name>A0A9Q0L8B3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related protein rab11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8B3"/>
    <dbReference type="OMA" id="TEKKXRS"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5067639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="215" mass="24676" checksum="6B34313B051AE276" modified="2023-09-13" version="1">MIAYETQWDYLFKILLIGDSGVGKTNLLTRFCQNTFDQDSKSTIGVEFSTKIIDVGQYIIKAQLWDTAGQERYNAVTKSYFRGAVGAFIVYDITSFVSFQNVTKWLNLVREFSNPNTQIFLIGNKSDLNHLRQVTQQDAKKFASQNDIFFQETSALDGSNVEKSFLILSEKILQNLVTSKQSPNNPQNFLVRFDEKFIQENKEKNSQKKKKSNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAJ9</accession>
    <name>A0A9Q0LAJ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 4b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAJ9"/>
    <dbReference type="OrthoDB" id="1748655at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="177" mass="21371" checksum="71ADFFDEDEDD9665" modified="2023-09-13" version="1">MKTKLKDLKPKDFEFPRSYEQKLFFFAEFETLEELKNLVEGNPKDIDESIENISPAEPKKEFQPRQDYNRRDRFSPKYSRNDRYLSKSDNFDKRSPKREFPKERPRLNLQERSKDTTQKGYRDPNIFGKAKPIDNKQKEKEIKKENKEKAKIRQLENQPKKQIPQNKFALLSDKIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB44</accession>
    <name>A0A9Q0LB44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB44"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="237"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="416"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="627" mass="74455" checksum="99CC68331F7A95C4" modified="2023-09-13" version="1">MLQQNNNNNNQLQVYKIGIFGDGNSGKTNFTYQFIQQIFIGENDPTIEDTYRKEIEIDKKKIIIEIFDTTDQEEFTYWTTSRKMQLCDGFIFIYSITSRRSFDEISILIENVLRVKDTDSVPIFIVGNKIDLEDQRQVRKEEAETFCIERNLPFMELDCHNYEQVESVVIQLSKLMKNWDHYIETEKRKKKKKWLRKLLVPKKECELPDEFTLPSIDIQQSSLQFDYDKIFQDKINTDVKFSFFDNSNNQGYSSFDAHQAILASRCFTFGKIFRGLKENKLEEIQQTCNSVNLKLIENKGEILTLSTEYFSIQSFYSMIRFLYSAIIDEEVKKSVKLSNDLLSISQIFKIDSLKNIMNKSISILDLQDKLKEKKENEKEILTQISDLENQISELLSNEIITMSNRFAMLLRKSPFSDFRIIIKEDEKARERRFFVHSPILSQRCEYFQLVLRNEMMEKKKEEILLSDISFDSFLLVIEYIYSDRFLPPNVITAKQTGNTKQIIQANKIMLELLIICDYFQIPRLHQLCQKDLMENLHEDMLVFALNVSSQCNAQILEEFCMIQIGKNFQKFKKDPQFKNYLDQEQKDQIKKYQFPPENYIKYHKKFKVKLAKKFGLIEKEDERLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBH5</accession>
    <name>A0A9Q0LBH5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBH5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="256"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="310"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="473"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="69257" checksum="CCD94EFCDDC92FEC" modified="2023-09-13" version="1">MNYCLFFGLNQFPILIKNKPNKITKPIQFKFENENEKQIKQILSGNISIIFLFKNGKAIKYLNQNPEKIQIEENIQKVAIGSRNEAILTKERNLFAKGKDINPNNSNEFINISSLIEDKNDRVIKDIVSGNSSIYLLTSNQNVYGNGSNYYGQLGFDSKTLKETKKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGSGNNFYFQLGLGESITEAIIQKLTKIQNIPKGKIIDIQTGFNFSIMLIENENENENPKRKLYSCGNYQYNGLGKNEDAYEFTEIKSSLFENDNNNILDFSVGNSHNLILTSNSKLIGFGGNSYGQLGTGDTEYQLIPIQIKLPKLRFNENISNYHISCGENKSFLYYSPLSFSNLEEDLIKLFERREFCDISFKTKNGEIIEAHKLILKYRLKDENQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYFEIKEIINSNEKIEETMKRIYLNEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTKDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDKIQITQQIIDEIEIGIDYFQLNETNPNLFHLLINKFNNQNYIQNQNQKKEKNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC68</accession>
    <name>A0A9Q0LC68_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavodoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC68"/>
    <dbReference type="OMA" id="TARGDMM"/>
    <dbReference type="OrthoDB" id="10259461at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051796">
        <property type="entry name" value="ISF_SsuE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43278">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN-CONTAINING OXIDOREDUCTASE YWQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43278:SF4">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN-CONTAINING OXIDOREDUCTASE YWQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="200" mass="22635" checksum="849170DB3855BD64" modified="2023-09-13" version="1">MSDLIKKPLKVFAVNGSPRYRGNTHWMIETMFDVFKDKNIKTESIQIGKKMIQGCLDCRSCYKTEKCAIEDDCINECYQKIKESDGVIIASPVYIAGPSGQIRTFIDRVGHLASMNRDKKRHSPFYHKVGASIAVNRRGGAAGTFSQLNYLFLAHSFIIPGSTYWNLTVGYNKGDSKEDKEGKFNIIDVAEEMSCLYFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC81</accession>
    <name>A0A9Q0LC81_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell growth-regulating nucleolar protein lyar</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC81"/>
    <dbReference type="OrthoDB" id="10677189at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="442" mass="52775" checksum="C46A26EF6069CF5E" modified="2023-09-13" version="1">MSFSIKSASVYQIYQLLEFLDLFKSEKQKEKEKEKENEKENEKENEKEKEMEKEKEKGNENENENEINEKEINEKEIVFWNVFKANKFEMDFINASFNTIQQTLSQINPQIQIIFNENEKVLNIQKMNGNNSSYINIKEYNELISILEDQINKKGLFDYMSLAKDFLDEIKKYCLKKFPFISKEEIEPIYIKENVGFQEEWSVHFDLAFESGDDYGNCISCPNPNNFNKRLLDACYELRGSGYGRVYADYFQSFFTHITHEFVHCIQSKKKQLDYSSLNWIIEHDASILGTSFFYHIVKNMDQKTFHKFFPIEGLIEQFILYEFNEALRLHKKSYTENIQKLYLNWIDDYGLNYPEEDDPNLVGQSVYYMKQRVSIEGFFYSEDLFNTCFEYCLKDRTGDLKKLKKIIPNQIKVDQQKTSISKLSKPLKEELILKFIERIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD83</accession>
    <name>A0A9Q0LD83_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytokine receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD83"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040302299" evidence="3">
        <location>
            <begin position="23"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="322"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="695"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="923" mass="102844" checksum="BE3BA4FE4477EF60" modified="2023-09-13" version="1">MKQNKLFFILIFLSLSITIFNSKTYQITEKQKAKTNFHKIECIPKDFNQKNYQEKCGKEISVSKNLILIGFPEASIRNNKNQGKVYVYRKEGSNWNKEATLIASDGIANGYFGSSCSILEDDILLVQTKGINSNQNSNQNLNQNLNQNSNQNSNQNSNLNSNQNSNQNSNQNSNQNLNQNLNLNSNLNSNQNSVYLFKFNGKNWIESKIPFSNLQNYLNFHEQVTPDNVTIINCTTLFSSFECYWYNVSQDNITYKINYNGDWNIIQNPEVQDNTLYQIFDSSNYPNISGNENYTIQIIACDAEDQCGNSTNEVNLTTRIDSVKNLSAITLSSTSIDISWNYPNVPIIEGVPKLDHYAISYSLNMEEEVGDATINNSSTSYNLSNLNSGSNYSISIWACQTSECQGDSKGEVSTISNTTIFGQVNLSCSISDSFTIICSWDEPNGTLSPSFYNFSYQSQNGEVIGSLNLTITNETITANYSNEEYYIYVSACDINGICGDVSNTTVNTLIFGQVNNLNCSISDSFTIICLWDEPNGTLIPSSYNFTYQSQNGEDIGSLNLTITNETITANYSNEEYYIYVSACDINGICGDISNTTVNTLIFEQVNNLSCSISDSFTIICLWDKPNGTLSPSFYNFSYQSQNGEDIGSLNLTITNETITANYSNEEYYIYVSACDINGICGDVSNKIVNTTIFGQVNNLNCSISDSFTIICSWNEPNGTLIPSFYNFTYQSQNGEDIGSFNLTITNETITANYSDEEYYIYVSACDINGICGDASNTTVTTTIFGQVNLNCSISDSFTIICSWDEPNGTLIPSFYNFTYQSQNGEDNGSFNLTITNETITANYSDQEYYIYVSACDINGICGNVSNTTINTTIFGEVNLSCSISDSFTIICLWNEPNGTLSPSFYNFTYQSQNGEDIGSKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD92</accession>
    <name>A0A9Q0LD92_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fam11a b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD92"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="500" mass="58987" checksum="8C9E0973F389DB44" modified="2023-09-13" version="1">MNPQTYLTLEFHLDWLKPETIKELKDLEENSNLNPNPNSENYFENFPDELMLLIFQYLDKPFQLGFCSCVNNQFNRISNDWSLWKPMLKKYRDKLDFLKLKLNYRDAKHFEMEGSNGICQYFLKNSNENENKNEIQNEKKSEYQNEYLDFEDQNIKIVDENQLKKITEEIEKDPRKVFQNQAMKINGLKKMYEKHKRKIDFENRVSNFKDKIVLNPFVMGLAFILGMTVPLILIILKLENKIDISWVVAFLPIFYTCIHLGMVGSVKILEGEGHGDRDIFLFWSLAAGSVIFMISLIFGGLKLDQKGIFKDTPIFVCAIPFFVLSILISTLVTLQILQQYRDKRYPFYFSFTTISLIIYFPIYTIFFSIFLILASLKVDYNFDLSWTKCFIPLFICDFLPVIGITMACLYRATTSHVYYSSIHQLNFIQLIVGTTFFAVEIMLLRKWDNKLSISYWLISLPILIPEVLGNLLIIGILIIEAYENYQRNKRTYDFDSNRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF82</accession>
    <name>A0A9Q0LF82_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquitin-like-conjugating enzyme atg3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_10020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF82"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040126939" evidence="9">
        <location>
            <begin position="19"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5071611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="465" mass="54020" checksum="942CE208BCF07FC6" modified="2023-09-13" version="1">MKILNFFYFAFILQIISPFYFDLPPLIGTCFEEFLEANQLIQGFYEAANDIPIDFLVLCPEKHTLYQKDSHPKEDFSFISHESGRYMFCFLPNKKTVVFSYKMPFKIKFEILPFLKSPDYSEFEELSMIEKEIKNINMFTNKIQDNMEYFKSREETMRDTNESTNSRVMWFSFLSIFVLCVAKFMKHKAHSAWLQLANKISGPLKKSALLDKGVITPEEFVIAGDFLTYVSKTWKWQPAKPGLSKSYLPEDKQFLLTEKIPSTKRAIDLVNMCVENLLEDDWVSPDFSKIQDDEVIVDESKNTKPEIKSESQSEAESDSDIPEAEDFDDDILIQTKDDAELSQDLILQARTYDISIVYDQYYSTPRVFLSGYNENGKPLTKQEIFQDISAEHSGKTVTFDPHPHLGTKQASIHPCKHAQIMKLMINQMKENGKEMSPAFYLIIFLKFIATVIPTIKFDFTHTFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFU9</accession>
    <name>A0A9Q0LFU9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin acylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFU9"/>
    <dbReference type="OMA" id="EMDVRRH"/>
    <dbReference type="OrthoDB" id="330152at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03747">
        <property type="entry name" value="Ntn_PGA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="entry name" value="Penicillin Amidohydrolase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218:SF4">
        <property type="entry name" value="ACYL-HOMOSERINE LACTONE ACYLASE QUIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PEPTIDASE S45 PENICILLIN AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="842" mass="97961" checksum="FFE1ABBDB2E06285" modified="2023-09-13" version="1">MNILNNIIGSFFKTVAYSKLPKIEGKIKTDKLSSPVEIKRDKYGVPHIYAKNINDLLFAQGYVHSQDRYFQMELVRRIISGTASSVLGYDPDLLLSDMFFRSCQFYKLAEQEYKSSSLELRKLIQSYCDGINFYLSECYKSNSFSFEISLLKIKPRNWDFLDVAAVMRFIGAEMTYDVFRKLYLAQLSQQLGIEKTMEFCNAPINKPTVVENGIEVNDVIEKVISNTMENVKTIHKTKKKITGGFAGSNCFAISGKYTESGKPFLCSDPHLELRIPSFFYENHLISKDGYDLYGYSIAGAPYILIGFNGTFSWGITLGMADSEDAYLEKIKGDEYLYKNEWKKLESYRETIQIKDHPDRIFNILKTRHGPLISTFYDSKLNLNQLENQNQNQNQNQNQNQNQNQNQNENQNQNDEIQYHISFQSIIFQHYSGKSLVNALYLVSQAKTYEEFSSVVDNCYYGSFNFTFADNNGNIGYYLSGKYPIRNEKWIKQFILPGWTGEYEWEEMIPFEKNPHSLNPKQGYVVSTNNNPGKTEYYIGTNFDNYRAERLNYLIQTFIDSGKKFKYQDLMKIQTDIKTFSGRDISLAIQNQFEEVLKSHDNKKISELYDILKKWNYDMDIKSVGATIYFLFIIKFFEVVIKEQVKDYHLSKFLIGSNCNTLIRGDEPESLTYPSFILSTITNPKCKWIEDCGGLNEVIKTIFEKIYEFGKEYFKSENIEEWEYGKLHIIQLDHAFSAESKIFNSFNIGPLPIFGCGTTINLQTYHPSYENFYKSSVGPVMRMIFDLGQPEDSFGVICTGNSENVTSEFYDNQFKLWYELKYHPLLMKEDDILEKEKYRLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFY4</accession>
    <name>A0A9Q0LFY4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFY4"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF134">
        <property type="entry name" value="PFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="505"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="718" mass="81353" checksum="5F8F5333B691E0D6" modified="2023-09-13" version="1">MTDLKEKANKKNGNTPLHFAVYKKSNIQVFEKIIQSGADLNSKTYENTPLHLAVSDPLTPLEILKILVESGADVNIQNKFTPLNLAIEKNANLEVIQYLINSGADINITDGYSPLMNSIYYHRDQAIIQLLLDSNPDLSLKTKETALFLAIQTKLANHIIQTLITKGADPNSSNNENCLFVACVKKHDLSIIQLLCESGADINQISDETPIEIAFRYGSSNEIIQLLLEKGGKINRQLKGVMSPIARVCSSHSFEVFKLIFDYGGDLNFKSDGSTLLHLVCTYDSKIDVEKKALYLLEKGIEIDAENNVSLLLENDLKMIIILKNETGSLWYAVNTRKYKVAQILLVKGADINHENRVKKRKKNKYFCVLILKWKFFLLIDTTLKTMLEKYGTLANDLSNLLLSGVGSDLELQTSETPLKTYRTLLELRLGKNNISNLESEVKKLNLNKAQKLIKMIVVGILIYTEDPQFKITYKSFGLTDLENFLGIQKLKQDLKRLYNDEESKNAVVIVDETKIRVHREILLARSNFFKDLYQSNEGDKDVFIDTNGKSAEAVSVLIRFLYYDEIDENELSDSVINELKDAKAVYKLNTNSRIDDILNNLGKTEEEIIESILGRNNNNNNNNNNNNNNNNNNRKKLSLMQQLQQSIKTTKKKKGKALSDPENSLTEKESVKPKRRDSFDNLINPNSLEKKQVDKKIEKSKSKSKSKSDSDNELDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG39</accession>
    <name>A0A9Q0LG39_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG39"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040150839" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="455"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="898" mass="101092" checksum="AE8AFB95849EA4B8" modified="2023-09-13" version="1">MKSNLFFFLILNIFLIQSIQTQQKSISTIIQELRTETTRYYSTPNEAWIWNLLSNFSGSTGYFGCSVSIQKDVLVIGTFLANQAFIYRYNGTNFELEQILSEPVLYFGGDVSVDGNVIAVGAHYGFQVYVYRYNGTIWNLEQILSEPSIPYFGYSVTVSGNVIGVGSYYGYQVCVYRYNGTIWNLEKHFQGVAEYFGFSLSIYGDALAVGAPGPNQTFIYRYNGSNWNLEQILSESISGFGWSCSIYENSIVVSSDNGNQVYVYRYNGSNWNLEQILSESISYFGNYVSIYGDVIAIGTGAKQAFIYRYNGTNWNEEEIFSDSALYFGTFISVYGNFTAIGAPGENQAFVYEAHLIPQVNILNCSSLFSSFDCYWDEIQFFRTVKYQINYGYDWIDIDSPILEDENVYYQQFNSSFYDNITGNEYYSIQIKACDVSTMKCGESSSFINLTTKIDSVKGFHLSNPSNYSINVTWNYPNVQINEGIAHLNHYNLSYFIQSEPDSISFISVDNSSLSYLLNNLECDNDYNVSICGCRTQECEGDDKGEVVESSISLFFEEVTNFSCSISNSIDINCNWNQPINCSIPFYYNFTYQSIYQNDSGNYQPTSSNQQFTAQFPNQEYQINISACNSNGKCGDISSISIKTDNLTAPIIYETISKIEEIEFNFTKLTNAKNYSISLNNGTNWEKFTSLDLSGNEVIGIISGIPGNIEYNISIRGCIDLNCETPYLGLPSSIISTRAKLGNITSLNCYSLINGFVCNWHPLILSSGLKGYSFTYNSTLICLPNLMNYYSITSGLKGGEYYEISVYSSSDLNCSFNEYSGMNSTTSITTLSPYEPCEPCQKTENSTNSNTTTITVGIIVPVAVISAIILAIILYKKKRKKQVIKEIIKEKELHTDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGC5</accession>
    <name>A0A9Q0LGC5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGC5"/>
    <dbReference type="OrthoDB" id="5560627at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="58"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="227" mass="27269" checksum="0F54264C772515AF" modified="2023-09-13" version="1">MNNNNNNQIENQNQNQNQNQNQNQNQNANQIEMKNLEKKVTKNLIKDYSNLLKGNSFKDFSIFVENKSNTFEIKAHKSILSSRSPFFNEFLKGKNHLNSISLKQFNKKEMESILSYIYYGNISFENQENLLQLLEISIYFKLNLLKEIIQKKIPNSINYSNFFQFFFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKKKKKKFFNLIFFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGE4</accession>
    <name>A0A9Q0LGE4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGE4"/>
    <dbReference type="OrthoDB" id="741027at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="466" mass="54617" checksum="71B571939ACC728A" modified="2023-09-13" version="1">MDLFEDLEKSKSFFELDPNTKHKIIQSENIPIHVYIDGDEKLPTILTFHDIFSNYQMSFQTFISHPIVQQKILKNFHFVHVEAPYHEFGNKITKKKIGKFTLEKLSKHVENIVHHLKLENLILLGIGAGNLVLFRFACNNIKSVKALIFFGGTSSTQGWIEWGKFQYILKIMNIWGITDYVVDSFVQKFFSSETIKSNLDLLENFKLQISKLNPVSVSEYIRAYSSREKIDSDKYKNVFDLDSLFIVGNESQDLEDSITFYSLFNKVSSTLLKLDSKGALITLEDPDILVNPLILFFIGIGYIHLNKYITSSTSLAKNRNQNEIENENQNQNQNQNENKNKNENENQNQNQNQNQNKINLENENQNQNQNQNQNQNQNQNQNRNQNQNQNQNENENENENENENENENENENENINEIQIKNENQNKNQNQNENQNQNEIKNENENQNKNKNENKINLENENKFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHG2</accession>
    <name>A0A9Q0LHG2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="2782"/>
            <end position="2880"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="2897"/>
            <end position="3168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3317"/>
            <end position="3349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="752"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="960"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2334"/>
            <end position="2475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="761"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="981"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="993"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3521" mass="420091" checksum="8341A20085E70B53" modified="2023-09-13" version="1">MEFIEEKKEEEFFSTFPNGNEIIQIWEKIKSKNPNEMNQEILEFCLLFKNAFRNWNPLQTKSNENLNPNQNEFEKYFEDEEINEAILNKEAHPIELIIFSITLLMYSKDLLQDQNQENKFLISLSIISILCKSKFNRQICFESGIFQILQDLLEISKNLFQSMRNLRNSNSSLSIYYLIEFQFIISEVMSILNHFLRERQVFPNEKILESIKQLKIISLLIECFEMILNLRKSYIFTEKQFYIQLKILENFENFYRLNLFTEKQKIEIIQFFSTFFNPPNLSSSLPNIGFPNQEEIEIEIEIEDFLQTNYFIFDPKIKKQENPFIFQNFKSLESNLNHFEFNFRSNALKFLIQITKRENIIDQITNNNNILYLRDLILWVSYDFKTKLPKKSEHLIKENDSNSLSNLAKMDSKEMENINPKKVSQIKLYNPYLDTLFQNLRSFQKIEKSNENELKKQNIRKELDKYTNETETHVNNFKERLVLIYLSLFKNTNSEISHPSLIHNISNEKIIQIQKYIKDICPELQLYILFEFNRMIINDNDQQILDFFQKNSGWEICFSDYFIRKQSIYLNSKENEMSINLQTLLIQFVFNVIVKYQEDFYYQLLFNQIFGNQNIKSDLFILNRFLEMIIEIIKTQPQIASKKINKIKALKEIEETAFQFIEEHENKTFNLSLEILDLLFQNTDIEIFFQNEEMVNSLMGLFENKNTRQIPLIHIPKVLEKIKMTNLEKENSFFSYLIQRILFLSQKINSKSNHQQKSNENENENENENENENENENENENENENENENENENENENENENENENENENENENENEKSNENENENELNDIEKLVSRFSESISNNREVIQQIFFTSNSLLIVKTLLNDKEQRLTYLILSILKEIMRKNERIISQFHNIVETKELIELLYETEKGNPSQKLLQILLDLMVNNGNFSIENNFIIRNRIMIEIILGIYSQNQNQNQNNQNNENHNNQNNQNNENHNNENNENHNNENNENQNQNQNQNQNQIQNQNNQNQNNQNQNNQNNQNTNQNQNKIQNQNQNQNQNQNQNQNNQIQNQNNQNQNNQNNQNNQNNQNNENQNQNQNQNNENQNQNNENQNNQNNQNQNNQNQNQNQNQNNENNKNNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNNQNQNQNQNQNHNQNNQNQNENENNQNNQNNQNNQNQIQNNQNQKSLFNVTLEIFDQICDKSIHNIYCCCEQGIISLLLKVISKIENLKLFNQIIQFIGKIGTHKILVSEMKEYFLILKDQLKKGKNQFANLMIDQLRKMIKENQNESQINFFDFYEENSNIQLPSFKNKLISKYFSFVTWIRIEDFQMDNFSSSRKDQNSEKYYQTKIFDFFTETLEGIQLLLSFDKENKKPELLIYQLYGNQDEELFEIRFPFGIETKRWYFFVFTQKYKTSSSELEISTYLDGKQIASTKIKVTRKIGNEKDFIKNEIGSDFMFSAQQAKIINPKSFFGQMGTIYLFHQFLNENQVEKIYFLGPNYQSFFYPNEILKYANPKIEKELKEIFNGELTQKIIIYHNPRQTQHNLCLNQSPSNIIKEHSKTKGICSFKTIPFQDIIRYLSGIEILLYLILEIDELFEEQREEEIFQVNQQNVFVVGIGNGNEITTQMLFEKILKMIPDVLLNDSIFQEQMIQKQGFQILSYILKSINPKYFSNHIYNLFRKLKEKIKNQEFQIQLKTHLLFDYEIWKNFRFDIQKKIVLENIQKNKHLPKTTTKLSEIDEIEEMVKTSEKSQENPENITIFDLLEILIYYDEVLNKILESDSFPHFSQLQKRIEDSTENLFSIIEILLDQIENEISKSKYIQSLISSCFFFKTEKFIEKTLSFFQKFINKNPEQNWKQLLSIKLFKPFIHLMKENPSTKIMELCLDIIFFIAISLHENQEVIQMLQSKKGFEIDELKDLYPLIHRILIDNNSEMSKEIVDLLFKMLIYENRNNKFQFSIIGNPCILQTICEILNYSPNLVDILHLHKLYFLMVESNLNKEKILSQFGWQKLLLYLINFLHYQFEPNQNELSNENQHQDNVNEIIFKMFKLLFIYCFHNPSYNFPEIFENFLSSVSLVHFSATNKETIPKIIETIIHDIFEDINHRSKKQNDSKNIYNKNSKRQNKNFINNLFYLLKVLNGISFNLSKNGIEVKQSEKQPQNQFIQSTFSKHFTKILKTKKAKKAKKTKHNLNLNTKTNLNNIFEVKFDLFGKKEILKNLLPILEKIGFFKEKGIRFKKKKEKRAIYKIIIFLIFATIPNSNIQTTNLLLSKLSEMINSPLNFKASSIRNSQELITICLSFLFSYIQNQNQNQNLNQNENENQNENQNQNQNQNQNQNQNQNQNQNQNENQNQNQNLNQNLNQNQNQNQNQNQNQNQNQNLNQNQNQNQNQNLNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNENQNQNQNLNQNQNQNQNQNQNQNQNQNQNQNQNQNLNEIEKNEIEKNEIEKNEIEKNEIEKNEIEKNEKNQDEDERKAKRNLFLLHLQIIMQENYNFLFGLFSNQNRKQSLLTENPQNSFIFSSQNIEEFQEEIMKEKWTKAANIIFLPINQKILEDIEENEKEFIKIQSNNIFYLKDSFNQVFKIKQKEIEDISQKIQIQIRNLILKEKKRILKKGIDQRKDMVYLQKFKKMLKNSILGKYPWVSNEMIISDGKFEKENIYPKLSETEDEMRRQKKINFHFKPNANQSGNECENQVKNEKKNLIKLNEKIKTKIIDQTDKLLKVQEQIKQIQKPNAKRRNISLSKKCEVISKTKRIQGIFQLADNSINFFEELNLKKEKEKNYLWNLEMIKSIHKRRLAFKHSALEIFFGNNRKCIFFNFETMEERNEIYDDILKQKFVNIDLTKYNYSGNEPTKWIEKSQMTKKWKERKISNFEYLMYLNTISGRTYQDLSQYPIFPWIISDYESEKIDLNNPKIFRKLSQPVGLLNNKVIVYFEKYEIDGKEKEFDFNYKQMYSNPELVSSYLIRLEPFKAICLKEKYPIFKSIPETWKAIKENAFIGELIPEFFHLPDFLRKPVIFENENEISSVELPKWAKTPEEFIQMHKEALESEYVSEHLNEWIDLIFGYKQRGKEAKQSYNLFHPSSYEENINFLNLEEEKTKKEIPIKGQIPIQLFTTKHPKRFSKEEIQQKNSSIFNLFEWKNILFPNEQFNLKSQHFSISENAIIFIHYREVKDIAFAQNYDQIITFDQERMIGNHKFDLIDSNPKKVNFSFAIDEKMKEQIGVAFSQDFKNFQGCFAIDKTADHLFCCGFCDNTFKTFKMENYKMIQSVSKHKDTVNCLALDWKYIVTGSKDTRVIVWEFDFKERKVKENPKHIFFEHEKEVKSVAISIEYDAILSGSIDGKLIFHSLHKGKCIQSIVFSDKQPISIIKISKEGNIITFSDNSAKLRLFTINGYLIQEVKCLQNIYSISITQDSNFIFLGGEKGILEIRKLFDLKTIQNFDIKETIYSTSIIDNNFLIVLGLENGELNIANFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI33</accession>
    <name>A0A9Q0LI33_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gigyf family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI33"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="1">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="167" mass="19864" checksum="C97C3FBA02A526BB" modified="2023-09-13" version="1">MNQENCYNKKELLSLFADLNWFMYFQKGEGATTETILQPVCFTISKGLSKDLSKDSPTDLSTESLKNEEKKETQWFYLDMEFKVQGPFEQKEMRDWFLDDFFPPYLFISREQDLIFSPLNQVYPYEKTTFLPDSIPQFPDYQTQIGSFPSQISWYTQKKLIQIFGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI91</accession>
    <name>A0A9Q0LI91_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI91"/>
    <dbReference type="OMA" id="IVEPWIA"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="247" mass="29126" checksum="B4A92B1FE5D5746A" modified="2023-09-13" version="1">MQDNQPKEEQKIIPETLKKKKEQIEKIKQERQKKREQQIERQKKNRQLAHDNAAKYEEEYKKMERDLVEKRRAAKAEGNIYVEPEPKLALVIRIKGITGVAPRQRKILQLMRLRQINNAVFIKLNKTSLRMLHFVAPYIAWGYPTLGTIRKLIYKRGYGKIRSQRIPLLTNEIIAKRLGKKNIVSVEDIVHEIYTVGPNFKYANNFLWPFKLNTARGGLSYIKRNFIEGGDAGNREEYINKLVKRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LID5</accession>
    <name>A0A9Q0LID5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LID5"/>
    <dbReference type="OMA" id="MQYEMQK"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="117" mass="14016" checksum="512DC431B6ACCFD2" modified="2023-09-13" version="1">MQQSELNKLQQQQQQKQQKQNNAEMQKKQAAMEEQRKAILSQILSTEARERLSRIALVRPEHARQIENFILQSGIRQQISEQQLIDFVEEFTKQTKKETTVKIQRKHWSDDSDEDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJC9</accession>
    <name>A0A9Q0LJC9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJC9"/>
    <dbReference type="OMA" id="HIICENN"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="434"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="636"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="669"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="704"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="739"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="807"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="841"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="938"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1109"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1212" mass="140378" checksum="DC9BD39613F912EC" modified="2023-09-13" version="1">MNIWEIILENNIEKLKQIKNISKNKLKERKKGKTILHFAIKKKVSKEIIEYLISKGVDINAKTNKKETVLHYACQSNSKEIIEYLISKGVDINAKTNKNETVLHFAFLHFACQSNSLEVIEYLISKDFDINSKTDINETVLHYAFEVIEYLISKGLNINAKTIYLHLLPLHIACQKNSIEVIEYLISKGADINAKTKQNETILHYACQNNSIEVIEYLISKGADINAKTKRNQTILHYACQSNSIKVIEYLISKGLNINAKTIGNQTLLHYACRTNTFEVIKFLVEKGINIHEKIRSENRTTLHFACQNNNLSIEIIEYLISKGADINSKTKYQKKTPFHIICENNSTLEMIEFMIENGADINAKTKQNQTVLHYACQSNSKEIIEYLIEKGLDINAKTNDDETILHFACRKNSVEIIEYLISKGVDINAKTKQNRTVLHYACQYENTLEIIEYLISKGVDINAKTKKNETALHYACRKKSFEIIKFLVEKGIDINIKSRYQLHTALHIACETNNSPKVIEYLISKGADINAKADRDITPLHYACQKSSKEVIEYLISNGADIKAKTDTNQTSLHFACRLNSIEIIKYLISKGADVNEKTNQNETVLHISCQNTPTFEIIEYLIFNGVDINAKTDINETALHFACRYLSIEIIRYLVEKGLDINAKTIYDQNPLELACQNQHLSLEIIKCLIENGADINTKTKQNKNALHFACQNSSLKPEIIEYLISKGIDINAKTDENKTALYLACRYDLSFEVIEYLIENGADINAKTNRNESILHISCLHISSFETIKYLIEKGIDINAKTDENLNALHYACRNKNTFKVIEYLVEKGVDINAKTNQNENALHFVCRNNLSFEISEYLISKGIDINAKTNSGMSVLSLAIKKQNYELIKILLMNDVNVFDLKLNEITNEFIKLFSQIYSINEDMNNLLKSNQFSDLTIQSNDYSKFFVHKLILLIRFDNNESILQKFINICYKKSKEDIQFILNFIYTGFIDFEKLKNNLSINQNQNQNQIQIQNLNLNQNQNQNQIQNQNQNQNQNKIQNQNQNQNQNIEEYQNEYLNELKTKKSKIKEFLKEIEIKKEWIKRKKGRKGIIKDLSKLYEKEETKNFKIICSNEKEIKVHKLILIIRSELFKAMFELNIQDSTNQVHDYSKKRNETIQQFIYFLYHDEFKIEINKNKNYEEINEELEDIKDYFQLNPNSIIDLILNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJK9</accession>
    <name>A0A9Q0LJK9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJK9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68756" checksum="AF7A5920E801B5B7" modified="2023-09-13" version="1">MNEILFFGLNQYPKLIKNKPNKITKPIQFKFENENEKQIKQISTGHFSIIFLFKDGKAIEYLKKNNSKQNPEKIQIEENIQKVTVGNENEAILTIEGNVFAKGEDINPQNTKEFINISSLIEDKNDRIIEDIVSGARSIYLLTSNQNVYGIGSNGYAQLGVDSETLPKTKKPILMMKNVSKIFSGNTSNHVFLLNSNQELFGCGNNEQGQLGLRKSIKEDTIQKLTKIQNIPKGKIIDIQGGNKHSIMLIENQNQNENENPKRKLYSCGYYEYNGFGKKYQNTYEFTEIKSSLFENNDNIIEISVGYFHTLILTSNSKLIGFGYNKFCELGTGDTNKQSIPIQIELPKLKFNENVFNYHIHCGFFNSFLYYSPPSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYFEIKEIINSNEKIEETMKRIYLNENENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVRDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJM2</accession>
    <name>A0A9Q0LJM2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase-associated protein leo1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJM2"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="242" mass="28862" checksum="44C4522D376A01FC" modified="2023-09-13" version="1">MQNDNENDNEIEIEIENDSQGFSNESFINSDSEISSIELDVTNIPDENMKEKQNEEEKYLEEKIELNQEGYEIKEYEEIPEENKIYVGKKTRFIQFEEDEFKEKKIIKENIENLTKSGYVVRWRYNDKTKQKESNSRIVKWSDGSVHLVIGSEYVNIEKLKHDNSHLFCLSKENNLLLFERTLLEKFSYKPVSLNTKIHHAFSRDIKERHKEKPKSRMLVPIQVENRQVTKKSKTNKHSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJY1</accession>
    <name>A0A9Q0LJY1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras and ef-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJY1"/>
    <dbReference type="OMA" id="NIMTQFT"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="204" mass="23159" checksum="FA8C8A2599E5B954" modified="2023-09-13" version="1">MSNVSDSLLLKLIIIGRSMAGKSCILLRFCDNKFESNLGFTIGVDFRFVSLNKNDETIGLQIWDTAGQERFRTITSSYYRDADGVMIVYDITDENSFDQVDHWFDEISKQAPPSVVKILVGNKTDLENKRKISTERGLNAANSRSCPFIEVSAKSGENVKKAFEMLVDAWTEKSKQHITKPRKKKARQKITNESFEKKDKGNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK26</accession>
    <name>A0A9Q0LK26_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK26"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="320" mass="37934" checksum="58F040B37D5078AD" modified="2023-09-13" version="1">MVSTIELIKRTARGASKTGSPQLYIISFTSLFLALLFLYEIIRTIRITKSIWKNVTSRFRILVLSFSFIGLFIQTLTALISFNWESIFLIFFFYVNLVYWFIYSSYIAYIFYVVKTLQLIEGKQTKIRKYSDLIFGILIIITFALLILFCYLDAKNLNDNTKFSDAYRLQNLYNIIWILPLSIIFIVISIKSYKKFGGYILVKIQKERIKYVLILTIIGCCFFGAFLIWVIFSVSGANKMSNNLKSYLENEEYSKFDNFNLFFHFIFFFIPSFIIFFFLHHILTIEKRMFQREENILLADPDDDGIIYNKNEYKLMDIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK77</accession>
    <name>A0A9Q0LK77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sesquipedalian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK77"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Clu" evidence="3">
        <location>
            <begin position="157"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="419" mass="49383" checksum="438F9B5D4E3D8A99" modified="2023-09-13" version="1">MEEKQIEFSGFLFQKAVFNRWNKRFVKLTKNGKLLIFKDKNDTKTKHEMDVTNYEVKTVPVSKFKKQNVFFLGMNISKGKKKKIYFSCSSEKEKNDWLEMINNVLHKRQDNYRPSLSLKSLQSLSPSSIKLHYSKQQNNQNNQSTTVSPTSTSKTALDYTDDESEFGQEVPNFIEDEMDWNETLRLLLQQLPPQRTYEKFYEIHENVQHEISILQLLGNFLHTAAYCAQILIDEYPLKKSQKIIKPIFNENCDPKQKNFLMEKEHFEEDQIPGIQYETSNMIFRFYHRYPGKLESTELSMKMANHLVQNGKFIQEANIIGVYVPLQCIVDYKGFRIHVSAQLPNNKRRVKLGEVVSPKIKKKLKDLLQKYCLNLDMENVDLLEVLEISENEVYLLNVEQLFPTEKFNYEDPIINLLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKG6</accession>
    <name>A0A9Q0LKG6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKG6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="338" mass="40149" checksum="345D2E1C9F35A694" modified="2023-09-13" version="1">MQNISKIQYLDENGYIDPNYLNEIIPWFRGGENLTPLRYSIFFEPNELLKFMLCYGAYLELDNPIYTYRSFPFKSQALLQLSGFTQKTISNIQHSYYSYYSRKKPNPKIDLDNIQSYLSICEDFEYLVGNEELSDMKFPGGFPAHSLLVKCRTGIEDLFKITEYFQTKTSEEIKAFLEWVYCGKINHLYPIYQYAKDLGIQNFVEKTFVEGLRNSLKELYEQDETKDFTIFVQGTEIKVHKLIFFVRSQLYRGMFLLVNDESSEVQDYSGKSADTFKIFVKFVYYDFWDETFSNDIVFELGDVIDYYQLNENSGLKKEIAKMKKKRKKENRRKLKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKT4</accession>
    <name>A0A9Q0LKT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inositol phosphorylceramide synthase catalytic subunit aur1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKT4"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5074747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="342" mass="40181" checksum="4D531B8E85961231" modified="2023-09-13" version="1">MNTNSNINQNSNRNSNFIDWHIFYCGNANFIHKKFPYISSRLLITLLPMISYFALPTIFHLLPKEDKPTIDIQGLPRLEYVIFRGFFHRWITQFINPVFDLISGTLYILHYIIPFIFSLYIWKKYKNPSRVAYLFWCLGIINTIGVTIQLLVPTSPPWFWEKSIALGYTPQLPTQGDPAGLSRVDSLIHYDLFKNIYSNSKIVFGLAAVYLWHHFLMDLIGGAFIVFLVLCFFPAPLNEIKNDIKIKNDIENGNDIKNEIEIKNEIENDFEIENDIEIKNEIEIENDIDNENENDIDIENENENDNDIDNENENENDIDFNSIFIVEKEEQNLNSFEIKYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL27</accession>
    <name>A0A9Q0LL27_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL27"/>
    <dbReference type="OrthoDB" id="5990167at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="589"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="626"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="924"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1024" mass="119671" checksum="B294E8A2B46E5AD9" modified="2023-09-13" version="1">MNQIEKNKKLFSVCQIGSIKEIKSLIEQGADITIKNSIFQTPLDLICKFQTKEDSFEIIKYLVEKGADVNSKSFGNETPLLLICRNKNSNSFEIIKYLVEKGADINSKNFGNETPLLLICQNKNPNLFEIIKYLVEKGADINVKSQFNDTLLHLICQNKNPNLFEIIKYLVEKGVNINAKNQFNDTLLHLICQNKNPNLFEIIKYLVEKGANINVKNQFNDTLLHLICQSKNSNLFEIIKYLVEKGADINAQNLQNETPLHLICQNKIPNQNTLQIIKYLIEKKTILDAKNNQNETALFSSFKNYLQNNNPIWIEIIKYLVEKGASVNVSSYHHGNLLSYTFQFYLQNPNPNLFEIIKYLVAKGANINAKNPSSESLLHSLFQVQNFNLLEMTKYLVEKGIDINTKNTQSETPLHLICQNTNPHSFEIIKYLVEKRVHLNLPSYQKQTPLFYLFKYKNEKAFEILKYLIEKGANINTQNDQNETLLYSACQSQNTNSFEIIKYLVEKGVGVHTTNKYNETLLHFVCRYKNTNSFEIIKYLIEKGVDIHTKTHSNQTSIHYVCQYQNEFSFEIIKYLIEKGVDINVKDNSNKTALHYVCQYQNEFSFETIKYLVEKGADINVKENSSNQTPLHYVCINGRKNPNLFEIIKYLVEKGANIHLKNNQNRSIIHLLFWNQAQIMEEEKLIQIINFLIQKGIDINAKANQDETVFSLAISKNCGKSIKFLMMNDVNVFDLKFPQIIPKILEYFPKVYSINEDMNNLLKSSGNFSDYQIESSDFSKFPVHKLILLSRFNNDDSILQKFVELCQKKPKKHVQFALNFLYTGFPDFDNFWEKIQRFKDLYNEYLQSQNDYKLSKFSWSEINKTRENIESSRKDLSKVEGEQQIISQLFKEIGFDSKWIETKKGRRGIVEDLQKLFKEDVSKKDFLIICSEKEIKAHKLILLIRSELFKGMFLSVEDSSNQVHDYSGKSFETIYQFIYFLYHDEFDKTKKQNKQMIEEEYQDLKDYYQLNQNSIIDLLLEDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLT3</accession>
    <name>A0A9Q0LLT3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLT3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="478" mass="56694" checksum="537406CFD5447A5B" modified="2023-09-13" version="1">MENYSNLEKLSNDLKNLFQNQNQNEKDEESYFDFEIICEQNKTSFKTHKSILSSRSEYFKSLFKSKTKELQEDKLILKDVSSSILSSILNYLYSGKIEFNSENAVQILIFSTKYLIDELIETSSDFIKNNLKFETVVDVLKLSESMDLNLLLHYCYQFILDHFKEFSKTSFFLELEENQLIPFLASNCFLGNEVELFQSVIKWGRHKSNINQKKANSKLNKKEKEKLQDQISNVIQKIRFIDFPKKELQKTLKEDLIPNQISRKLKKLLTLKTKKDEKKIKKFIKKEKAKAKEKEEEEKAKKEKDENENEDEDEDEDEDEEKENFLIFNPRLNFKSRIIKKKRYIQKLRKWINDDKIFYNVQLGFSTHYIGFSTRKWHELCDDCENTLVIIKTKDNFIFGGFTKVGFITDKSKWNEDQVFESRRICDISFPFSLGIGRSNFGETYNLPKGIKLKKAEALSYLSGSIVWEIDEVETFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN57</accession>
    <name>A0A9Q0LN57_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_01099</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN57"/>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040282451" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="163"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5074468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="520" mass="59427" checksum="3A41EB4467401DCD" modified="2023-09-13" version="1">MNFFHLLIILSLLLSLNFSQAPLIWPKPQSATYGTKEVIVDPTTFAIHLQGAGSTSQILQEQVQYYLGLLFPFTVVKSKVDNLDSSINLLVLNVKSDNEDLQLGVDESYNISIYSSAATADANTIYGALRALETFSQLVSYNYTTEQYTIENTPITIIDYPRFPWRGILIDTARHFLPVSAIKETIAGMAYSKFNTFHWHGVDAQSFPLYITKYPQITTNALFYKNYFYSTQDIQEIINYAKKFGIRVVLELDGPGHSASLGFGMPELTAKCPKYESNINNIPVDPTKDFTFEVLNDIWTEMSSYLLDQHIHFGGDEVVTGCWLDDPDIKQWMADHGMSTTQLEEYYWVHMNQIRDNLGKKSVVWQEVYNLQNSTILKNAMVQVWNDISNIQDIVNNGYEAINSYGWYLDKQIPGTQTHYEWIDTWIDFYNLEPYNYISTNRDKFLGGEACSWSEQVNWSSLANRLWPRAAAVAERLWSSKDTNDVSDATVRLNQQSCRLVQRGINSAPLYPGFCFVGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNI3</accession>
    <name>A0A9Q0LNI3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fukutin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNI3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040174686" evidence="2">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="231" mass="28101" checksum="BB96F2A9AB705857" modified="2023-09-13" version="1">MKFLFLLIFIQLILIQSILTQEEENSSNEQEKVNSESSKGSLLELYEYVIQYLKKEQEESENLQKGFISLIEALREFIKNFKDEFDSEKTEEKFKEFIVELREDPLYQKVFVALLFRNENSLIQAFPEVALKLKDFSPQLGSFFGNFLAKTFGVEKRTKRRTKRRTKRRTKRRTKRRTKRRTKRKTKTKRKTKTKKKQKQKQKEKQKQKEKEKQKQKKEKKEKEKEKEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2024-05-29" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNK7</accession>
    <name>A0A9Q0LNK7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1516" mass="181894" checksum="F93205B828E44DE0" modified="2023-09-13" version="1">MLFLSDVSIFSLIHQLFSDSILLYRPSLMNSFSQQKLNLEEKIDRLYDNDDGDFNSTLSIIQYCLFEGKNLIIFDYPEIYTFIYQLFSSFRIEENGIFSTHLFVKNETRRITVNKRFRLVVVVTNPLRYELQHPDFLDCFEKHFVDHSFLEKTVSTLKADIIQNVESILKPFGKFKPKKIPKEELIVAFNSNLSISLTLKYEQNEILIKKKLIQFCKFEKMVEIRELLKNKKKPNSNSKQVQEIIDLYFNSFYKNFDDLFTKEIIHQKIKNSIIFTRTKASEYPFLKEQYNSYSFININFQTSFGMDNKLIDQLVSKIDKTEIVTFAHFTQSQAEDFYKFKLILDEIILQNEKRSQTEKTNFDIANHFKKEKKQCYFILVIHLTSNTKIQEFPFCFEKNWEHYYVEELFPKLPLQNLPDDLSSFFILLQENKFDDLWKNMAGLILSRNFSFMHEKYFDLVNFIQESFLVLKKDLITAKIGSMIQNGIKENHYIYKFNIADFFQKQLKEKEKEKEKEKTFHELIYEHFMDKMIEIIHIFFTNINLNGNLLLALLSSTSTSELSSKHKNRRKKNRDSVFWKIFEKFQVPWFEIKSPNSHNFEMQADFSSIIFSLLFDEQKKQNQNENNKKESVEKYFFPKISLITYPFDNNRMNKFSHNKQEKEDAFIQKYFQDWAKLMLDTKQKENFDKLNIDFVLWIKKILGKEEKNCQEISLKKACDIFIKQILPNLYHLIEISPLVISEKQKDYFSFQIFMKTLITNFNEKNPRMIIKVDSVESLFRFFIEIECKKGESSKKYKNLYKNWEIQKLRNANLSPTLLETLLSKSSQQNHQMNGFSLPYKRIKDEMRLDIISVEYLNNLFNSDHNHKKFVICPKSKQKPLIYLNENENENENEKCPICQHKLHKKRKHFHAIKKKDIQKYREDLIEKILQFARFLSFYGNILFERFLFDNKFNGFFNFQKMKSFVDFCIEQRTLFSFSFTNKNNQNPNEVFDLIFAPLLNNIFSLEFDKTKDFINEILQTKNSDIIFLSLSKFLIQNEEILHNLSKNWDLNENMEINLDQQNYNLEEVVRIINKRNDLMKNPEDIDDGMKEMLMRDYMEPWLKFVFYQIEIARGRDHLREFVKEKFSSYKKKNSLIRTIMKNKKRGDSQKKPKKKEEDQSLFDLYEAKQTEIEKSKSKSKSKSKNKRDSQESIDSWFLRKDISQLKNIFKDKKEIFLKPAILTLELISKSKLEPFTKLLSFHFVSKNYSKETHNIQKIYFPAMGGYPFTKWHFKNRTKWKVCKAKHLNWNLPVFNQLNNICQFCNENLEGSKVNSHFFDNARSYFVPCNPNTNLGFKIRQMHPVTFRIIRLFTHLSAVLVAVLSPKFLSSFIEIMNDYIFKPRKEQLIDQLFAHIENDFLILSELLFVSVYQASLYYIKFLDLIQESSILKDFLNFDEFENIETRNNFEKMFNDIYKQNDKIILSKIKKITEDEIVQKLEQSPDLKIFLIFQNQIYFPLRKIFIKIAKGKITKKFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNL7</accession>
    <name>A0A9Q0LNL7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNL7"/>
    <dbReference type="OrthoDB" id="6418787at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="230" mass="27500" checksum="5565CC52CFD84889" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFQNQNQNEKEEETYFDFEIICEQDQTSFKTHKSILSSRSQYFKSLFNSKMKEYQENKLILQEVSSPILSSILNYFYSGKIEINSENAIQILIFSSKYLIDELIEFSSNFIKNNLQFEIIIDILKLSESMNFNQLLDSSYKFILDNFEEFIKTSFFLELEENHLNSILSNDNISINEFKLFQSIIKWGKHKSNINQKFEQRRKRKNSKSNFQCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPS6</accession>
    <name>A0A9Q0LPS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPS6"/>
    <dbReference type="OMA" id="NIEHPEC"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="125"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="540" mass="61209" checksum="8CAA181468A197A1" modified="2023-09-13" version="1">MQAQVPMSGFKIMLTIKCQNLLKKDKLSDSDPMGVLFAKDANTHELTEIGRTEVIKNNLSPKFTTTFELIYLFEVIQIYRVTIYDIDNESEKLEKHDVIGSIDFNLGELMASPGQTLHRRLEYAKLPARQNGMCSVIAEAMSNTNLRAIFDCCAHKVDKKDTFGKSDPFLTISRLKEMEWIPVHQTEYIKNTLDPVWKKFKVSLDILCGGDLNRKLKFEVYIGGKPDFIGEFETTAQGILDSPTKKFDLINPKLAEKKKKYQNSGIFEFKYFEVGKKPTFIDYLAGGLEISLIIAVGFGRSYEMEIIEPIPRFSEEIHNDYKTAILTVGSILAQYDTDGSIPAFGFGAEVGEKIWTTHPLNNNIEHPECDGVKGVLKAFESVFEIPNFQLSSLIVSPIIEKVARIVREEKKDKQKYHILLVLVNESIPDLSSTKQAIIKASDYPLSIVFVGIGDNNFRDLEILDADDGKLKYDGKDPKLVRSEKIKAKRDIVQFVPFRDFKTKGMDKLAKATLAEIPKQVVQYFSKRNIPPNPPRMPLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPZ5</accession>
    <name>A0A9Q0LPZ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein rab-35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPZ5"/>
    <dbReference type="OMA" id="ECKIRIW"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001329">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="208" mass="23614" checksum="6501BC7794188218" modified="2023-09-13" version="1">MSFDRLIKLSLLGSAFVGKSSLITKFVDNTFIMSTTTTIGVDFRAKDVDVDGKIIRLEIWDTAGQETFRSGLGNAIFHEKEGFILVFDLTEEDTLKEINNFLVLINQNCPPNVLIVLVGNKCDLENQFENLEEKIKEILPNNEFKLFKTSAKDGTNVNELFEYIAKTLKENQPKSKNEYLLKNEKNLARNGFVNILEPVPKIKKSKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQE0</accession>
    <name>A0A9Q0LQE0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQE0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="279" mass="32988" checksum="C90E6771348776EF" modified="2023-09-13" version="1">MMILFSKFNNSNSFLQFQQFYFSSIFQEKINQAQKYSRKKNTNFNFYFSSFQVFKFSSFQVVKFSSFQVVKLSSCQVVNEKILNQLFVSSTNIQVINQVICEFYKYSSNKSSYQVICKFHKYSSNESSYFYQVICEFHKYSSIKSSCQVICEFHKYSSNKSSYQVICEFHKYSIIKLFVSSTNIQVLNQVIKLFVSFINIQVLNQVICEFHKYSSDKSIIKLFVSSTNNQVLNQVIFIKLFVSSTNIQVINQVICEFHKYSSNKSSYFQAYYHYTIPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQG0</accession>
    <name>A0A9Q0LQG0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_05591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQG0"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="181"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5077901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="467" mass="54230" checksum="3BDCAB49F438FA63" modified="2023-09-13" version="1">MEEEKVNEFKSQANDLFQKMKYEEAIELYTKAIEIKPNAILYSNRSICLMKLEKFMQGLEDANKSIELDPKYPKGYYRKGSALFELMKFEEAIEAFKQVVLLAPNNKLAREKYQLCQKEIKRILFEKAISRELEKSPFETLTFNKNDIPNDYDGFILPENNILTFEIVKEMIESFKNEKIIHSYYAFEILKQIREILSKLPNVLELSVSENQLLTVCGDIHGQFYDLLNIFEINGYPTENHFYLFNGDMVDRGSFSLEVILTLFSLKIVFPQSVHLHRGNHESSNMNSIFGFFNEVRTKLDFKFVGLFTELFDLLPLSSIVENKIFIVHGGLPSKEDFKIEELKKIDRKQQPDTGIMCDLLWSDPGYAIGIRPSPRGLGVVFGADRTQKFLENNDLQLIIRSHEVKMGGYEVTHNDKLITVFSAPNYGDNMNNFGSYINFRSDLKVDIKQFQAVPHPKTRTYYANMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQP0</accession>
    <name>A0A9Q0LQP0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQP0"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="652"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="685"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="959"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1058" mass="120691" checksum="8F00DEDD6775AEE5" modified="2023-09-13" version="1">MYDYNWSGPKDIYEAIQRRNKEFIQEYVKSHKKPLNLDILRTALKEKLEKNLIISLTKKGVIMEEQKKDEIPLLYLACEKNLDVDIIRLLLDLGFDPNEKSIYTKQTPLHLSCENKNSLSTIQLLVERGAQTNKVDLKEYIPLFYALENSDLNVIKFLLQNSDFSSYKKPKNMNFLHFVLCKPDARLDVVEYLLSYGVNPNEQDLDLRTPLHYACANKCQTSILDLLIKKSENFPKISLKTFGNIDHQKNLESTENIHQQDTPIKIVNVLDIHKQTPLHELCVLNYTEDRINVLLKAGADPNIQNPKGKTPFHLICELNPSLNLVKMFLESGASVDIQDLEGKTPLYAAIEQDATYDVIYELISKASNFEISDKTTNVTLLHLAFKKSLDLELIKIILERGAKINAQDSSKKTPLHYCTEKNKRQEIGKILLEIQKEKLNSGNLDDNTTSLNLFCEFSTDAETIKTLINKGADPLASDSEGQTPLHFACINHPTFEVVDILLRAGADPKSKNRRRQLPLHLALEAKAEQNVLEMLIKFLGSKEILSLDFKKQTPLEIALRKKYSFSTIKFLIENGAMKENKSGRGGQTPLHIAFLPPIDSKVVKLLLDNGADPDKPNILGKTPLVLAIMNNASQEVLDLVVTQKNFDFPAKSGKTPLFFASSANNIEMMQLLIKKGAQIQVHDKKRKSILHYAILKGANVEVIQLLLDHNADPNEILDNNTTCLDLCFLGKESPSPVVELLLKICKFDSSVQNPFEKAFSLALSHDASFPSLLLLAETGIDLTTFKMERLSFLDSVYIMKNINQIRLALSFDLNLSIDFFYENEKMLICKDFYSIMNDFERILESGDLSDFNIVLSDGSIPVHKFILQNRICLPNEKIAFEKALDIFHSGLCDFQMSEVKPFLRFVYSGYIDHKDKKYEQNILKIGSLFNLEHEWFNEKKGRRGLLKDLKRLWFDDKSKDFAVIVGDENVKLHKLILAIRSELFRGLFLSVDDPSNKVSEYSGRSPQTIKQLLKFFYFDELDFVISSVVASELDEAADFYQTNEKTLTWKILYNAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQS3</accession>
    <name>A0A9Q0LQS3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ell-associated factor eaf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_00331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQS3"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="367" mass="42095" checksum="277BCCE8956AE23E" modified="2023-09-13" version="1">MDIDPQIRKDIEYSLNLGETFFTKDENNFFLSFRYDFKPQSINKDKPGNLEIINQRKANLTLSSKKNTHEKFEGTFSDPNERDCLLIFDPETNTFRLEKMGAHVTNLRHITTLTSHTQTININDNTNKRKHSRKDPKSKTKSKLQKNSKNSKKGKKGKVKKKSHKKSSQTENQNGHDKKIQNQNHILNSNKNNDYLFPQPNQVNYEKNSPFDSTNSDFDSKNLSTSNSNQKNNQEDYEEDNGENGEFFITLYTPGENENENENENENENENGNQNQNQNQNQNQNQNEKANYINIIESKPLINSNENSPQNTPIHQAVKPNLKPISLREQGMGIPNSFSSSVSDSESESDPKSESDFSSNSDSKDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRW9</accession>
    <name>A0A9Q0LRW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gata zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1593"/>
            <end position="1637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1640" mass="194093" checksum="B71C3DC290912046" modified="2023-09-13" version="1">MESFHPNHKIIENFITQIAQLLFVREYNRINEKEKETFTDFVKSQFGNEFPFPSNNSQIFYISQEKLDERLLILKKQIILASSTNLALIIKNFFPYRNLNLPQNILFSTFGKSSETPSPFDSNLFPNMLFVLETIYQCLNYLLSLQNEFLLSEISTDFVENLFSIIIGSENFSSKPVKELAADCLKIINSRNSKNMEIISNLFLANTKAQLSLSSPYLIDPQFCSKFLQFYCPISLEIKIATNLIKEYYKIIHNVSNIHLRREICQTLTYIFSSIFPRLTDFEEIWRRKKTAFEKPKEQDSEFFNTLFTHFNQVLELMLNWIKKDLNSFVYLDCLIQLNEGYQNIEEGLQQSFNKTTKKIFSFLISRLRKKQTFQDILFELSFLFFRSNFGFPPFVSVEKFLSNYSDIVKKFTPFLLNQEKKINTRNQIQSLSKIIYEICVKNEKICQDFLYDNIKNSPKQSAMKISCIQALCWIVTPQEQKSRTLHLNELNITQIQNPPSFFANPMIHFRFFSFFFDTLLNPENLVTLTFHEHENNIETEEPKTKKITEQKKLPDSEFSSLLLIKTLSVFPHFKSAKLNENILITKKLLVLILQDDTEISKQAIKSIFNFISLKQEGIIQIYLEIFEIMVDLFQKLSFFIPFGNESENQNQNNIPRLRPLIQAMIRLLTELKPILKKNPNWEPTIRFPHWLGLRLRFQGCCVFWLSFIDLIPWIQQDILLLIRNFGDNSIKNLEKMILLEENRKKNQEILSDQINFPHLSDTLVTNQNEKPVFFRDSEEYHQFIRADIFTHFYSVNWAWNISYYNFFQHSQITKMIANPSSKQFACIILGFMSYAAFLYSDDFYLFRINKYLKLNEFRDKNEDPEKNISLENQGKKVSEELPNASQLKKLSSHHRIQREYFQSQLTEENYISDSQTLNKDNVFDSSLRPLLYVHFLGIIAKLITQKEDHFARKIMIKKITNLQPSSFEHLIHFIYFRAKFEQEQNTLTTQNTKQPSDQFVSLQDHLLLLLEKKMSKLSPKFYEIADKFHVLLKSFIASWHGVCVRNNSQIKYKQRKRIINIIYFFLLKLTQLCAPDLEQNNNNNNNNENQIRNSNSFENSSILKIIIELVRMLLFHKCVIEKEATSRYKTKMVQRALLSINMSLKFMTEIEKVEKDEKMTRFFISSMRTFGDFAFKPACLSLQTILSQNPLNYDMFCHLSYNFDKGDEFLSQMSYQFFKAITNTFLQNGEKWINIENRFSLEEILIFILIHLSSLNNKIFKKISSLVYYLAHLEKHPLRPQNENSKFLFSVPHQNSDSNIHIALLYSHSISLSFPKFTESVIIHFAKIFPIFNPETKWNLIEILKPWIRNFRFLENLNFDHHQQSSILNAMILISKDLFESSLLVKQLSSFWVSLFDSSKLTIFSQTEKKDDQIQQKWTFVLSFILDILTASIKTKTIYSFPLINFIFLSLCQENSKFVIDFLLDHLTLFDEPPEETPKFRKWIQDKVDLHCDYEDAVLILLSNIVIEYPNYSIHYLPKILFYCIVNHPGSPISNNIIYNIINSLIFQAAKSKEEYFQAMLFLKSLKNEYEWNSFKPLKTGAIEYGYWFEKLDETQRSNQNQFNENQNENQNQNENQNQNQNINQNQNKIQNQNSKFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS41</accession>
    <name>A0A9Q0LS41_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_05800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS41"/>
    <dbReference type="OMA" id="PETRINW"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="437"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5077701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="57803" checksum="B945C9189D71FCF4" modified="2023-09-13" version="1">MAKSQPLLKIGHYEIGKTIGEGTFGKVKIGTHDKTGHQVAIKILNKNKINTHKMTAKVVREIQIMKMFIHPHVTRLLEVIQANTDIFMIMEYIPGGELFDYITKNEISEIQARKFFQQLISGVHYCHQRRVVHRDLKPENLLLNENLELKIADFGLSKIMEDGEFLATSCGSPYYASPEVVSGTIYVGPEIDVWSCGVILFALLTKKLPFNDKRTSILFQKIRKAEYIIPPFVSSSAADLISKMLNPDPIKRITISQIMEHSWFSEEIPNYILEWKSYGEILTRIEKPDPEILKLLCIYLNSNEKTALKLLKSGQNQEYILFYKLIYEKKLEEKKNENNDNKNKNENENETKSNQEEFNLKDIYSIPTILKKNQRESQSKRGVIHDKQWNLGVVLRESPEKIMSEVYRVMKLCKLEWFIENDFRLRCRISKTENDFQNSNKQIPDIEIQICLFSLVKNEKKFVLDFRKIRGEIFWFFHVCSFMINSLEIEKFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSD0</accession>
    <name>A0A9Q0LSD0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26s proteasome non-atpase regulatory subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSD0"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="164"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="380" mass="44355" checksum="25EF7CAC4F6BA648" modified="2023-09-13" version="1">METLQILSEQIPQLQGDFAIIQQLYEKKLWHQLTEKLDELMTNPVFRIGDILQTFYTGFLMKIETKLNPLKVVSFVIEVSRTIPDLEEKIKLLQNLLRKVEKSISSAILLKLEISRILLKQNDLIKVNEILQDTKTLIEGSGGISLIESNVLASYYQVSYSYFKFKEDYDKFYHQAMLYLTFEKLENVPVFNQQDLAFNLGLAALISETIFNFGELIAHPILESLKNSNYNWMYELLHAYNNGDMKKYEEIISIHNDEMENEILLKKHHELLKQKITASALVEFIFRQPTESRVLSFESIAQFLQTQVDSVELLIMKCMSLNLIKGTIDQVDQVLKVTWVIPRVLSQNQIQVLKDRLQSWNSRVHEKLLLLESETQELFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTN7</accession>
    <name>A0A9Q0LTN7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cofilin/actin-depolymerizing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTN7"/>
    <dbReference type="OMA" id="QCRFAVY"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="140" mass="16293" checksum="94F048EA9272A4A7" modified="2023-09-13" version="1">MDAGIRAEDECIKKFNEFKMGNSISYLIYRLSDDLKRIIIEKIGEKEETFEDFVSSFPDESCRYGVYCVNYEIDDGSKRSKIVFFSWNPEKAPTKEKMLFASSRSNFKKQLVGLSVEFAVSDKNEFMIENVIEKVTSKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTR6</accession>
    <name>A0A9Q0LTR6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MHD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTR6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057984">
        <property type="entry name" value="PATROL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008528">
        <property type="entry name" value="unc-13_homologue"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31280">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31280:SF2">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25761">
        <property type="entry name" value="TPR_PATROL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD2" evidence="1">
        <location>
            <begin position="268"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="413" mass="49260" checksum="867B31125F1B580A" modified="2023-09-13" version="1">MNFNFIHSIFDLWKVVVSIKEIFYQVLSQEIIELIAKPFFEDLYQIFRKYSRLVRITFSKSKKSNQQIISNESQKNQQIKQKSNQFIPNESQKNQQIKQKSNQQIISNESQKNQQIKQKSNQQIISNESQKNHQFITNESQRIKTIELIVDNKFPRYLISQNCVRLNNLSLVIDLFNKLCNEFKQKTEEMMKQEEYFDYGNILNENNNNNNNNEKNIKAFPFQTTQNKLKNFVKKKCVFPTAKFISSQIIFYQLREAFSFKLYLPDINYRINNVLIYLVSILSEIQNDLTNEEHKQNLFDFIYDDFLKCFEYVLLEGGRFYSPDDTPIIVEDLDFIIQFFAGKKNSDIKFSISEDQVNNKIQKIRKILLNLFPLSTENLISLFSTLGTIIQEKEPFIKINFQRILLERKDFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU23</accession>
    <name>A0A9Q0LU23_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-related protein racc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000050">
        <property type="protein sequence ID" value="KAJ5078676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU23"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="403" mass="46959" checksum="F60BC49DD26BB035" modified="2023-09-13" version="1">MLLRRDTPVVKCVLVGDSKVGQNEILISYLEKKYPEGYIQTVFENFSVKLNVDNEEIELSLFQTSGLEEYDSLRPLSYPNSSVVLMFFSIDNHSSYTNIVTKWAGEMRHYIEGVPVILVGNRVELRDDLEMIKDLKQRGTHLISHEEGLELAKKIKAVKYLECSPQTQKGIKTIFDQAVRVGLNYQKSQKIVYSKKEKKQKIKEEKQKIKEESQDFKIKCVVVGDDNSQRTEMLYNFKVDEFSDQEIPEICENFVVEIESQERIYVLNIFDTTGKEEYEEFRKFTYPDTHFVLICFSIINSISFDSVISKWVPEIKKNCPHVPFILVGNQNELRNDPQITKIIEEKGLKIITYQQGLELAKKIQAINYLECSSRNKKDLKAIFDEIVQYFNNLKSKKQKCSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU45</accession>
    <name>A0A9Q0LU45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU45"/>
    <dbReference type="OMA" id="TIRIMPF"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="877" mass="100133" checksum="CFD4FB093827A4AC" modified="2023-09-13" version="1">MSNPEISLEKCPKLTDEDRQKVKGAVGRRMRIDFQGWILKNNIKHQRIEERILVLTQYQIITIGKRKTSVRTTVCRKAHLNDLVRMRSYDKNHIKFVFREFYIDIYSEEADAIYRKTLRNIFSIQRGFAEKFRVKYDTRNENEIKLKHLSDQGFLESYKSMCQQHNTPPSTLFMKFIEETISIRNPVERRKLDFSKFRNIDLYLEQAVNPEPIIEALTHNRHFRELRVIDLYRKDALQIFCPCFRYNTTLRKITFSGMDSPLGFDEFGNAMKENPETQICYIDFSRNSFTKKKTMDFFEGLEKMNRGLIHLDFSTCQIDSSLASSLFSSLNKNQNHHSLRVLNLSFNKKIGSKGTSALVEFIENSKANSLRILSLANCSLNLEMLFKSFTKNSSTSVLSYLNVSGNSFDKNTYDSCVEMLQSTRSLESLDISKTKVTSDQVGNLIEMIQKSKTIQKFTLNSSFNNLGLSGAKAIVESLQKTSESTVLRELILDSSGFGANGMEELLLSNGVLGGNKGIECLSLSYNWTKSEAAKVVDVLCKMAETESPLFIKFLRIRGNKNGCLGPNLQNFFKNLSRLTSISGLDITGNEVGSEGMSNIAKSLNSNKQSNLQSFFFDGNSSRRFLAKNIKVILKLKLKMFSWPNQDEAEFIEKDPKEYEHYHDRIPKIKEKFSLYLQNSRSSFPSFVRITPDSSEIWSKNSMQSHHCMQDLLQYQLETFQVTNSEDFFGLVNDLSDTNEDQQDMIIPPAYEAKEGEQSDDEMNPDAKKNKTPKKNRTPNSTPKSTPKSTPKSLRRSNSKSNSKSNSKSNPKSNRKNSSNIPTEIVPPPDDLQDLPPPVIQNSDDTFPPPVNLENIPPPVIDSDDLPPPPPISNDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU87</accession>
    <name>A0A9Q0LU87_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="2">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000014">
        <property type="protein sequence ID" value="KAJ5080076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU87"/>
    <dbReference type="OMA" id="QPIMFRR"/>
    <dbReference type="OrthoDB" id="1845775at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1510.10">
        <property type="entry name" value="Domain 2, N(10)-formyltetrahydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5080076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="620" mass="68001" checksum="9A3357BF482E5869" modified="2023-09-13" version="1">MKKLEIKTPTPTDIEISQSSELLTIEELSKEIGLLSNEYEIHGKYRGKITLEVLERLKNQENGNYVLVTGINPTSFGEGKTTTSLGLSQSLGAHLNKKVFTCLRCPSRGPTFGIKGGASGGGYSLVVPMDEFNLFLPDIDAVSIANNLCAAAIDTRMFHESYQKDIDLFNRLCPKDKNGNRLFTKSMLIRLKKLGIEKQKPEDLTDLEINQFCRLNIDPQTITWKRVVDVSDRYLRKITVGQSQTEKGRIRETGFDIAVASEVMAILALANSLQDLRERIGRIVVARDKDSRPVTTEDLGVAGAMTVLLKDVIKPNLMQTIEKTPVLVHSGPFANIAHGNSSIIADKIALKLVGKDGYVVTEAGFGADCGAEKFFNIKCRSSGLTPNCCVIVCSLRALKTHGGIPLSECKKPNIEGVIKGCSNLKQHIENISKFGIPTVVCINQFINDTDEEIAAVITEAKKAGAFDAVSSTHYARGGEGAIQLATSVIEACQMKNNFKFLYELNLPIKSKIEIIAKEIYRADSVKYEGTTEEDIENFEKNGFGNLPICIAKTQYSFSHDPKLLGTPNGFVFPIREIRASIGAGFIFPISGDISTMPGLPTRPAYYDIDIDEKGNITGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUI0</accession>
    <name>A0A9Q0LUI0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUI0"/>
    <dbReference type="OrthoDB" id="2324840at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="307"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="483" mass="57205" checksum="159E930DF1B418AC" modified="2023-09-13" version="1">METYLNYEKLSNDLKTLIENQNENYYDFEIICDFNSNENSIQNSNQNSNENSFKTHKSILSSRSHYFKSLFRSKMKEFQQNKIILKDVSSQILSSILNYFYSGKIEVNLENVIEILIFSSKYLIDELIEFCLNFIKKNCQLEIVVDLLKLSDSRNLKELLDFCYQFILERFDEFLNSPFFIQLEENHLISILSNDEISTNEFEIFHKITKWGKNRLNINQEKRIIDNQEKEQFKNLISNVIDKIRFIDFSKEELDHVLKEDLIPNQISEKLTEFQKLEQNDEKELEEFIENQNSFIFKQRFRFRSSIIQEKQQVNQLKEWINDDKNFARMKKGFSAKQDGFSGEDFHNKCDNKGRTLIIIKTSNDSIFGAYTKVGFISGNERFIEDPNAFIFSFKNPNNDPPQKFSIKEGEEAFALYHRPGFGPYFGKGYDICFNYNLQPKMFNFGLSYNLPNGISYASDEARSFIAGFFGTWRVEEFECHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUS5</accession>
    <name>A0A9Q0LUS5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUS5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5078904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="382" mass="43904" checksum="47E2F35C77D86EDB" modified="2023-09-13" version="1">MINFEDFNQEYQPLVIDNGSGMIKAGFAGDDAPRSIFPSISIKPRFYNPLITNEKPKFLGGDEPQINREIMKINYPLENGIISNWDDMEKIWHNVFYNELRVSPEEHPVLLTQIPFNPNSNKEKTAQIMFETFNVPGFYIANDLCLSIFLSGKETGIVIDLGDSISHSGVVYQLNILPHSVQRINFGGKHLTEYLTKIVNEKGFSFTSKLSDVEIIKDLKEKFCYVALDFEEEMVLEKQNIEKIQKNYELLDGKFIQVSNERFKIPEILFNPNLLGLETYGIHNSIYKSIMSCDLELHDSLFDNIVLSGGSSMFPGIEERLQKEFSFLVKNQNFQIVSPSERKYSVWIGGSILASLSTFRNSWILKEEYEENGIKIIYQKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUW8</accession>
    <name>A0A9Q0LUW8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000037">
        <property type="protein sequence ID" value="KAJ5079111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUW8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="486"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="70448" checksum="869F083C2C66DC26" modified="2023-09-13" version="1">MNDCLFFGENNKQKFLKNEPEKITKLTQFKFENENENENENQIKQISSGYFSIIFLFKNGKAIEYLRNQNPQKIQIKNIQKVIVGCQNEAILTKEGNVFAKGRNINSNYPNQFTNISSLIEDTNDRIIEDIVSGYSSIYLLTSNQNAYGIGDNYYSRIRSNFITLEKTEKPILMMKNVSKIFSGTDSNHVFLLNSNQELFGCGDNETGQLGLGESRKEEKRIDKLTKIQNIPKGKIIDIQCGFYHSIMLIEDENENQNPKRKLYSCGYYQFNGLGINDQNTYEFTEIKSSLFENENDYIREICVGADHTLILTSNSKLIGFGGNWSGQLGTGDTKNQKIPIQIELPKLRFNENIYDYHLSCGENNSFLYYSPFLSFFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSVKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERNEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIKEIEIGIDYFQLNQTYPNLFDLLINKFNNQNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVW0</accession>
    <name>A0A9Q0LVW0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-amp-activated protein kinase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVW0"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10414" checksum="E082643D1019A7A8" modified="2023-09-13" version="1">MSQLFPVTFRYLGEATSAFLYLSIDQWQKPHEMKKTENGFEVSLNLPAGKFYYRFAVKQNNKIFWVVDSEAPKEKNNKIFFLLIQKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWV6</accession>
    <name>A0A9Q0LWV6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWV6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="105" mass="12519" checksum="C019D05FAA30DED2" modified="2023-09-13" version="1">MQTNLTSSLFLIKNTRSFYFSPKINYLLINLGVQLFTCPSLEISNIYKSIQNSKSNPQKKNQQQNVLIEMNDFRIELEQKDKNKKDKNQKKNQKNYLDFLDDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX69</accession>
    <name>A0A9Q0LX69_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX69"/>
    <dbReference type="OrthoDB" id="27341at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="163"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="334" mass="39631" checksum="F5D5D30527E1B815" modified="2023-09-13" version="1">MKNLEKKNERLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFPKSFLVDIQNKIIQDNQKENQQMKIEIEEKWKKEVEDKKKEIEEKNKEIQQMKIEIEEKWKKEVEDKNKEIEKMKPVFDEYEKDLELQKKLEPIKKNFPQFSETRIITEEEYVKKLQEWINNNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGFNGNTGWTNDANAFIFSLRNDKGDRIPAKFTYKQGWAIRSDLSLGPVFGDDFYLVSNLQPGYSNIGYSYNPPNGITFNTNESKSYLAGSYDKWVVDELESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX86</accession>
    <name>A0A9Q0LX86_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX86"/>
    <dbReference type="OMA" id="HPPICAY"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF148">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="486"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="563" mass="66087" checksum="E9087CAF17AEEF62" modified="2023-09-13" version="1">MSQNNNNNNNNKDKPHNNSQKPNKDEPTIQTQIIQKNENEKPNENLNENISNPNENQNEKEIQIENDGDEDEFQTLENENEKENENEKEKEKEPKKQTKREIKREEKEVTSFRRKKFSKRRYFFRKRSPELFELFSMCEKFPKKVRIPRLGIKKHEIEKTAFDLKVWDRIKGSKNSGGWVYQNVEEVKKQRGIVWQIVKNIASNLVSKESDLEYFSLPVSVFEPRSYLERLLDSYCYAPIFLNLAAEEKKPVERMKLVICMILAGLHNTIIQLKPFNPILGETFQGLFPDGTKIYCEQISHHPPISSWQLISIENQFHLYGKGKFVSTFKGMSILGYQKGVITVEFRNNEKIEFTTPSLSLKGLAFGERIVHYVGKSTFVDKKNGLQCEINFTPHSSGFFKSIFGKGNKKPTDFFEGDIIKTTKSTKDNQEIETTEKLCHIQGSWLGKIDFDDQTYFSVNDKFPKFKPIPVDKPLPSDSRYRDDLIALKKQNLKEAAKAKHKLEEIQRRDRKLRREYHPNDSQKEIQAIVIDHPTEENYEELEKEAMKYVKEEDKKKKQNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXC3</accession>
    <name>A0A9Q0LXC3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXC3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="461"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="566" mass="65756" checksum="9A349BA95D3004D4" modified="2023-09-13" version="1">MNDCLFLQISSSLFSTIFLFKNGKAIEYLNENDSNENPSKIKIENIQKISIGHDNIAILTIEGNVFAKGKNINPKNPKQFINISSLIEDKNDRIIQDVVSGACSIYLLTSNQNAYGIGSNQDCQLGSDYITFPKTKKPILMMKNVSKIFSGNTSKHVFLLNSNQELFGCGYNFHSKLGLGESRKEVKIRKLTKIQNIPKGKIIDIQCGFTFSIMLIEIEIEIEIEIEIEIENQNPKRKLYSCGNYQSNGLGKNDTYEFTEIKSSLFENDNILDFSVGNRHTLILTIKGKLIGFGNNSSGQLGTGDTKNQLIPIQIELPKLRFNEDISNYHIYCENEKSFIYYSPPSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINSKLYFEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVRDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXE8</accession>
    <name>A0A9Q0LXE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000041">
        <property type="protein sequence ID" value="KAJ5079070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXE8"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="262"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="436" mass="49636" checksum="66DB28031E360866" modified="2023-09-13" version="1">MKKLPKIFGWGYNFYNQLGFQNDGFYVQNPNAFHIFPGHFVSQISSAIENTCFVSSSDEIILQGYFCEKKKIDPKIKLPGIKKIQSTGRGTFIANTISGSVYCWGIPMSEINLGVSLNLNTPQKVLVFEDMFIKDIACGKNQMYFLSQNGDLFACGNWGIKNILGDTSSFLYSPNGEKTSLFLLFKNVDKIYSDACCSEAFFITKDFRIYCIGLNVWGQLGLGHFKEVWQPFEHTKFFAEQIMDIRMTSSSTIFLVKEKGCGQIYSCGKSEFNGLNSHNAINRPQKLEMPDHDIIAITTGSSHSIVLTSKNEILIWGASNSYGQLGKPSLKENAKTPFLHSISQILQSTPFHIAISSGPITSFIFYPLDSYLIQDFLRFFQREENCDSKIVFFDGEKNVHSNVLNMRIGKEKCSKLFSILKKEYKFENFKRYWIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0M007</accession>
    <name>A0A9Q0M007_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0M007"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="242" mass="27541" checksum="AE92C096FCEFCEBE" modified="2023-09-13" version="1">MNEIIFFGQNQFPKLIKNEPDEITKPIQFKFENENENENENEKQIKQISSDYFSTIFLFENGKAIEYLSENDSNQNPHKIQIENIQKVTVVGNNQAILTIEGNVFAKGKDINPENPKEFINISSLIEDTNDRIIQDIIFSANSIYLLNSNQNAYGIGSNKYGQLGFGYETLEQTEKPILMMKNVSKIFSGNFSLSVFLLNSNQELFGSGNNNDGELGLGESIKETKIQKLTKITKYSKRQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R415</accession>
    <name>A0A9Q0R415_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R415"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="16909" checksum="F71EC37C70104183" modified="2023-09-13" version="1">MENFNNFKINLLEARDCGVGHVFLEEHNAKKNDVEKQINDFLQRHNLKPLTDWIHINETKGKEMLLGFLEKDLAYHSRLMSFEQAQGFTNQFFEFFDLNSLQVFTNAEIDGTSVSWSGVTQATFDQIIVCIDNRYIGFVCFEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4B6</accession>
    <name>A0A9Q0R4B6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4B6"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="685"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="725" mass="84416" checksum="02BA2EDE7F9E01D7" modified="2023-09-13" version="1">MNTNTMNTNIMNTNIMNTNTMNTNTMNENTMNTNTMNTNTMNTNTMNTNAMNTNTMNTMNTNTMNTNTMNTNTMNTNAMNTNAMNTNTMNTMNTNIMNTNTMNTNTMNTNTMNTNTMNAMNTNTMNAMNTNTMNAMNTNLLNLPNNQLDALLSDECTIDLKALLKTEAALSDFTIICGKNLKEFRCHKLILSSRSQFFHSLFRQKDLEIINFAEFEYGIVDPVMGFLYTGEIKIPQQSFDSYHKLADKLILPKLKIKIEKDIQQSLNQDNLVDVYSKSKRISSDFLIQSCGDLLTQNIDQMIQSNQVQKINQHEVICFIEMMLLNKTTNKLKLIPGLVIEWFKYNNLKPQREYSKLHLKNLQIPFYKSIFQLLEHIQFLHPISDYQMYQIQKFSFFPFETVVEIYNHHIETSIQAKEQKLIQEKKDLKKKTKELIQEKEDLTKDKETLTKEKEDNKKKQKEIKIKEKDVTKKEAELGKKETDLGKKETDLGKKETDLGKKETDLGKMEKKNAKEKKENQKKEKELTKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKKEIDLGKMEKKNAKEKKENQKKEKELTKKETDLGNKEQELIKKEKELLEREKDLLSRIQSNNVEIEKELKLLDDEFNKSDYTYGATLLHYFAQKEPINKDLFNHFINLGDDWNKQDNNLSNNLYNILIILFIILILTLILSLSLLIYIFKYSLYPLLDLFSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4K8</accession>
    <name>A0A9Q0R4K8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4K8"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="33188" checksum="FBD0A147B32A47E3" modified="2023-09-13" version="1">MESSDYEEDITIQSLFNGLTNILSSWEIIKLIKETLIFSDKTEDKIQDFEDDLMFFFQENLDKNKQIEEFEVKNILLDSLSNILHIDLQDGSELNVVKELVLLYQNISSNNLDYVENLISRLEKEKEKENLNEKENQNENEKEKEKEKEKEKKKKKRKRKIKIKIKIKIKIKIKIKIKIKNQNQNQNQNQNQNQNQNQNRNQNQNQNQIQNQNQNINQNRKKKNNKKKNKNRNLKNFNNKKTSNNSQTKDNEDDDDNEDDDDNEDNDGWFIVKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4S6</accession>
    <name>A0A9Q0R4S6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4S6"/>
    <dbReference type="OMA" id="NEMNIHR"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012389">
        <property type="entry name" value="Cyclin_P/U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027110">
        <property type="entry name" value="PREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR027110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="200" mass="23446" checksum="A4D01BFBA6DA912A" modified="2023-09-13" version="1">MDHLLIKLSTNISNLLSQLVNLCEDEEKDTNNIFSVDLPSISIHDYVQRLVDNLRCSQQCFVVAIAYILRIIKQNSNIFLTKYNIHRFLVTAVMSAAKFFDDQFYNNKFYATVGGIPLEEMNKLELEFLFLIDFQLVISREEFTKIFRGILAFENKQTTPKQPFPSRKRKNENIDVVVHQKNIQENIYSSHFQTKQICLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5C7</accession>
    <name>A0A9Q0R5C7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_12769</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000123">
        <property type="protein sequence ID" value="KAJ5067962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="7">
        <location>
            <begin position="1207"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1638"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1684"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2065"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2185"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2216"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2249"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2316"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2421"/>
            <end position="2453"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2454"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2487"/>
            <end position="2519"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2637"/>
            <end position="2669"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2670"/>
            <end position="2702"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2703"/>
            <end position="2735"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2736"/>
            <end position="2768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1911"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="742"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="859"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1056"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1936"/>
            <end position="1946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2832" mass="326830" checksum="4C577C60A435F4BC" modified="2023-09-13" version="1">MFCSLVFITLTEMMIRNKQNQEDMITSSGFSMISYFLKQINSENLSSKIFDSIQKLLIETQDKKFRRDLVENFLMDFDIWIYCRPKIQKAVLSVFSMLISCSQKKEDVVIKVHDLVDIMRVYYWLKPDKYSRCQEDKIGKMAGEFFEKRPNTQDIREMRTKFLHIIELMMNSISELNNSSVNLEFLLVSCFVSQETEFIHEIIQLIQRIFTKDLQLFGEVLPSIGFMDLFIFLMDTQDDSIRENCLQIINKLEEYFVVFNDDQILKKKMKLESRVSEHSGFNLIHDILVKYPLTTPIANTLFSLIVNKKASKTKNINKSKTKNNGNITIHKWDIQNTFIFKTIFQLIGSSQNHLGIDVLKAAKNIILWNQQNKNIFVSQFGWQKWMIELIGIVPNQQGKHIKDARSNGNQSENLGDLEEEKEVRLSDLDISVISDDQTTTTTESDEKERVHKIRLWKSQSFFIKSKTKNINQNIDEISNINTDSQQSILELSQEVLSLFKDLHLHSIFFIKDGWKHLETTISLINLFFISKRNMDHESLIFKFLEDIFEGILEKLEADEKKYLQINKIFIENMYKLIVFLDVFHNKSWNESQPKPTQSLMSPLNRATSLNAIQFNKQRMDEKNLAKIFQRNWMKKKRTSQRNKYDNLTKILVKVLDQMHFFEKKAIPFGDQAKAHLVNDIVLEFLLNIVFVEEKAKKKIKYLGILEQFLEQKIKIHKLNERTRRIILVVFSHLMKFFFVELKNVDELKIEEENENIQKIKVELNKLMKNKKEGINEEEKLEEKDRNKQLCLIYVAFMFNLLPQKSRNYIFSHLEKQKGKNIFEKETTTTTTKLDSSNEAYLMQIFMGRDWKALLSHNFLEERKKIYEEIMKRNKEYNDRQAIVVENVKHILENEYKINRLFAKTKRAEIKKKIQKLVKKERNRIDKQNIQRSAKYRFVEKKCNRILRGIIYGRGPWSDELSKQKLHWKLDFSEDHLRRRIKLKPNHKYKDHKKAGISRGRNMESVESPIVLETERELSRQAKESMTTLQRILERSNEAEKKETRQSTTEWAGPKSDTNDSDRSVEFEQDIETERNKIQALSMKEGEQVQETLYRCNCWRIYGLNKQESMLEISTSLLSLVVSKKEEVDQQVYTNTGGGKEYYWQMAWIIAVFFRRYIHKETAIEIFFQNGRSLLINLENKTKSEEVFRKIISHKHVRSRGNVQYFTGHPRSYLRKLGLKKKWRKREISNFEYLMHLNTISGRSYNDFGQYPVFPWVLSNYTSSVIDLKNTENFRDLSKPIGALNEERLKSFKERYNSFNDDMMPFLYGTHYSSPGVVLWYLIRMEPFTSFAVQYQGGKFDRPDRIFHSLELAWQNCLRNPTDLKELIPEFFYLPDFLENSNSLDLGALQSSNRVLDDVELPRWASSPEEFIRMNRDALESEYVSENLNQWIDLIFGYQQQGKEAEKANNVFHYLTYPNLVNFDKIDPRDLLSVQSQIENYGQTPTQLFYKKHPKRISIVDFDVRQTLWNFTNISSPTHMFSLQISENPIVFVKLIGSHQNLSFLGSFGRVVLVDKNRVIHNGEWIPLSESKTSFPFLFDQERSAGTGKSFAISFSRDMKNFSNCMALSTTNHCLMCCGFWDCSFKSINIENLRIIQNVKKHQNIVTCLAIQKSVLVTGSKDTTVIVWRFDPKKGKVKRNPVHILVGHDDEVSCVDISIELNIVISGSKDGTCIISTLKEGEYVRTFSSSTQNPVSALKISSRGYVVVYSEQDMMIRLFSINGKFLKEIPCYQQISSLQISKDNNFIILGGNKGFVEIRSLYDLLLVHQINIGSPIFSLEISESERFIIVGTILIPSRECVFELSTKSRKNTKSLLNIILDAFKENFPNDKPLNIEYLQICGKKYLPTEKVRIDSNCKTVIVSEREKVDQRKKPVAPSLDIQEIKTKRRKRSTSSKNYSESSVFTDSENSERSSQDDPQTPISYRRSSRSSFRSFDEALFDFELFKNQFSMSNEPQSPIKKLAKAIKQKNTSLLKEVLASENLSFDLFTKENDGITPLILCTQYEYLEGCRELIELGVSVDEEDQEGYTALHWAGYNGNAEIVDFLIQKGASPSHQSRSGKTPIYSSFNRNQKKCVLIMIKMCMKTLIKTITFKKKSDDFDDSIEEDDSIGGWNELHIAVLENDISKVEEILSKKEIEINSRSSNEGFAALHLAVDFPECLKLLLDNGADVNLIDNFFETPLHKASQIGNLKSVEILVSSKANINFNNIFQATPIHFCATEGHVECMNVLLKNGANPNSVDFSLSTPLNDASYNGKIECVKLLLEQKNILVNTSDQVGFTPLHDACSNGNLEIIDLLLEAGANIEAKDIRGKTALIICTIYNQMEAFLLLLRHGAQLLNSDNEKATSLHWAVSEYKIEIATKIMEIIHKNRSKYNMDITDQDGVTAVHEAAYIGNLEVIELLVQYGANFQARSSEGWTALHWAGHGGCVKSVEKVLSFGAEIDAFDFTGRTPLFVAVEAEMMGAIQTLVENGANILQCNYTGCSILHTMANTKSSDVIDFILNSLRTRCAEISQLKVEVLDLNNFSPTPTNSLSESTKTKLSTFLELDDHTQSTFKSMLNMRDYEKKTAIMHCCEKGNDLFLTKLLKSGAEPSLKDISEQTPLHLAALNNEAKCIELLFKNSQCLQLPDNLGHFPLHCCSATRSFESAQILLHNNADVNCRDKLLSTPLHDAACNNDVRSIALFLDFNANINISDSAGVTPILAAAMSGAIDAVMFLIQAGADLLCLDNEKNNIFHFVVQSDSPKLLQFLLDFPHLLNIVNKTNIYNKSPLDISLDLENHEMSELLLPFSSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5Z8</accession>
    <name>A0A9Q0R5Z8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5Z8"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04519">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="376"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="758"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="919" mass="108386" checksum="E7D74F9D8E9F7296" modified="2023-09-13" version="1">MENSLKQKSQKELDFEIEILTNLINESKEEIKNIKTELKKTTKKIKKRSQTPLFVINEQRINCFDLSNLSNRAIMDLSEINCEFQTVLEILDQNFRFDKQDGNKLRNIFCGEDKFQKEHFLNKKIHLFIFSELEKIILHYTHIDLSSKIALILVQFIKKTFEKENQKDPFLNAVQLSQVLKDNGFKFDEESPIFYTICNLMFFIDFQNNFQNEIISQLSHLLSSRKIVQSKSQNQQIISETLERIFQKYFYGNYQNEHFAQNLVKFLKKIKEKEAEQKIDRIVSISFKNSLGITINTLFKNFVDSQKMDTILNFIQESKQTAEIPNLQNPNRKQIDHLNHIKTLKRVHELISNYLPSEEMIELFVAVSNSNVFEYPPEILVNILFKILDRLGILLPFLQVIIFSECMTNVLSGTLFRANNLTSKMLSKFSKNFGKSFLKTTFGSIINEIYSCEKSFDIEDLNLPEEQKQQNFSNLFYFYEKFMDSLVQNIPNLPIPLKIVCHHLYCASQETYPEKFQDILNGFLLLRFFCPAITSPNSYGICKNPPSRMISQGLLSISSSVQHWGYGYEFGPEKPEMAPINEITKRKYPKFTSFDFTSNPVPKGSNQNKTILYDQKTLNIDSKQFIRELRSSIFNFINPITSFFPKSSVHILSTISKEIFQNAQKFQIIIQNFAQNLENIPQFYQEIIENAQIHFKLKQEENNQENIIQENNQENIIQENIIQEENIFIIKDNDKSEQIFQADFIFSDSHQFEIKNEIKIENQNENQIQNQNQNENENENQIQNQIQIENQNEIENQNLIENENQNENLIKTWKQLNHIPSHLESFCTFRIENISQKVHICLKLNFIGIQKIKPFEKIIEIINLSKDLKVYEVRDSQNSKLRSICLEKDQDHSKIFITFDNESEHISWFENIKFLLKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R652</accession>
    <name>A0A9Q0R652_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R652"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="100" mass="12222" checksum="0B9464C5138E5007" modified="2023-09-13" version="1">MIIFLQNEILNQKIIRTLNLCENFKKYSQNWNEEKKNEEIKQIEKMIKAKRDLKALEKYIPQILIFEYQNNIILREKQIQILSKICEFYENQKLNSNSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6A3</accession>
    <name>A0A9Q0R6A3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6A3"/>
    <dbReference type="OMA" id="LSPNKIM"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="418"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="653" mass="77203" checksum="A903FE2EC30363F3" modified="2023-09-13" version="1">MNNFNQFYNSQNYSPFLTTIPRTDPQFEKIIFVAGKHFLKYFDGIKKNFVQNNPQQDNQNVEKESFVIYQRKRESQSLQDIKYRIVSFSSIKQVNFNLTPGFRYQKTQKEEVVLSLNENGNLFPTFYFLEKNKLDELLTKLEEIKKDLELDFQILNQNLNPNPNQSQILNQSQNLNPNQFLSPNKIMNPNPNPNQSQILNQSQNLNQNQFLSPNKIMNPNQNLNQNQILNPNPNPNQNQSQILNQTQLENQILNPNPNPNQSQILNQNLNQNQFLSPNKIMNPNQNQSQNLNQTQLENQILNPNPNPNPNQNQSQNLNQNQNQSQNLNQSQNQSQNQNQNQNQSQNQSQNLNQSQNQNLNQSQNQSQNLNQSQNQNLNQNQNENQILIPRNIQTNKSQNLNPNQFLSPNKIMNPNPNPNQSQFPNQFPNQMMNPNQFPNPNQFPNQNQFPNQNQFPNQNQFPNQNQFPNQNQFPNQNQFPNQNQFPNQMMNQNQFPNQNQFLNQFPNQFPNQMMNPNQFPNQFPNQNQFPNQFPNQMMNQNQKQFPNQNQFQNQNQMMNQNQFPNQFPNQIPNQMMNPNQFPNQNQFPNQNQLQNQFQNQFQNPNQFQNQFQNQFQNQNQFQNQFPNQILNQNQNQNQNSKSKSKSKSKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6G3</accession>
    <name>A0A9Q0R6G3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ring finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5068979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6G3"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1138" mass="137799" checksum="568A5F0BEC5633B7" modified="2023-09-13" version="1">MINKITNELIEELFSENINYKNQNFNEKCSICEEEIEENDTKHFRTIRKSKIEEYRKEIINIFHKFSKYLTFYGRIIFQQFLFKKKLTKKFNFGFIQKFLNYSIEKIEIFLKVKQIENIYSIFYPILKNLLSFIQNENSNEDNKEIINFIDKFLENTNQEILENKPENIILISCIKIINENEEIRNNIKSIQQNLFKNQDSPNLKKESKPNLKEKNIITAISKNQFSIQNIIKFIEKRKMLLRNPKKIIQKFKNSFSKKSGEIWIKFIFNEIENDKGRNYLQKFIEKEIPDKIKKLEISQNVLNSKRNDSIIIEYPKKNKDQSLLYYYEQKEIENDLSLKFEYSHISFVSEHKISYIISQFYRKFWEIEKEIENKEIFKMIIQSVEFIDNIKLEPFQFLFSSDLLFEVGESQLKQEMLEKLYFLSMGSHPFQQEFEKEKGYWKLCENKHLNFVKSSNIKLQNWCEFCKSSLKENEINSKFFENVLSYSVSKIPNSNPLLTYRNLHPITFRIIRLLIHSSILPFSIICEKFSNHFISMINNCVFKPKNQKELIKQLISHIGNDLFIISKLTNLTNYQSILYYYETLKLFSKKRIPNFLLRKDNFKEVEKRNKLEEIFSDIFKENHEKIISNIKRKYKINKKLQQSKTKINLFDLSKPNLYPIINLYIQKKEEDFEKYPLIKFIIENYSKLEILNLFEGFIKFTSLIMKKMNGKISKKEAKVIQIQKFIETENNPIINKLYLQFEKFWKLSSKEIKYLQITKEINDDNFKDEIKKEDIIDFCLTGKENYNLMIPILIEHSINLHNELIKSPFLKSIFQDSQHNQNNENNENQNNENNQEFKESILHFPKILNSDFIKIIKFNIQEFQEFINYNNLIQELDYIEEFIRKKLNYLKETNIFKIEIENFNYYGKQIEIKKEFLETEKKWEQEELNHDQWKQIKEELEKNNLFETFEKLIEYIILGCQNIKNENKFSKLKDLSIIEFIKTKLEFQFKFEFKNLEDIENDLSKFKQFAKMKHLLFIHKQFKDNFENILENLDKKFKWEMTSFQISLLENSLEKITKKIPIFDFICVLKDFIKKLKGNLNINNNNNNNSFRKLFLFSIKDKTTIIYKEIEENFDNDEEILLGNISHVYQFCSNIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6P3</accession>
    <name>A0A9Q0R6P3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-binding protein m</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6P3"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="532" mass="62281" checksum="924B340BD79BAB26" modified="2023-09-13" version="1">MSILTFFDDNTEQTIGPSKLILSKEQIYAKLENENTVIYSQDPPGGKDAGCVKTDEPFRTDQRIGYFEVEIIDCGVNFEMSVGVSSKKFETTTILGAEYSYAIICKNGNKIAEKRSYNYGPEFEKGDIIGCCVDFHQKCIFFTKNGTKLPTAFSQISDNFYPTICVRSKGEQARIILQAPFRFPIDYYIESQIAKENEKIDSVKINQQSIFNLVQKYLLFHCLVGTIQKLGILLDEDVKHKLQTRKSIIELIKNGEVNQAIKLLQEFYPYFLIFPKEYNLNYEKMKIQKYKKRKEENLERKEGNQKRKISSKQKQQNSNENLKQILNENLKQILNENINENINENINENQIENQIENINENINENQIENINENQMDIQEEYYSFDKLESNPKNQTIQNQNYEKVTEEEEKKRNLLVIDLMCQEFVELIRKNNIIEAFDFARKKLYNEKNKSNQKASQKIMNVIGLLGVPKVKENVNQERRNKIARKLNAQLAKYDGFAINDSLDRFIKQLFIVKFLHRKNLLKRGEIFQIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7I9</accession>
    <name>A0A9Q0R7I9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7I9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="415" mass="47894" checksum="DD2D66A4E9BE61A7" modified="2023-09-13" version="1">MNEILFFGLNKNPKLIKNEPDEITKPIQFKFENENENENEKQIKQISTGDYSTIFLFKNGKAIEYLFNSNQNPRKIQIEENIQKVTVGYRNEAILTIEGNVFAKGRYINSKNSKEFINISSLIQDPNDRIIEDVVSGSGSIYLLTSNQNAYGIGDIKMVNLVLILTPLDSLKNQRNIKRRKIHKLTQIQNIPNEKIIDIQCGFIHSIMLIEDENLNLKRKLCSCGYYHYNGLGKNENTYEFTEIKSSLFENDDNILDFSVGNAHTLILTSKSKLIGFGNNFNAQLGTGDTNNQLIPIQIELPELRFNEDISNYHIYCGGSCSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNEIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7S0</accession>
    <name>A0A9Q0R7S0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7S0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="90" mass="10488" checksum="8680BA5ACB40806D" modified="2023-09-13" version="1">MDNNNNNNNQIENANQNENENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R880</accession>
    <name>A0A9Q0R880_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho gtpase-activating protein 68f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R880"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="13"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="473" mass="56664" checksum="78C011476E4F71C7" modified="2023-09-13" version="1">MNSKYKRIFSKNIKLEKEIPFFIQECFKFLIKIKNPNEKIFFKNVNPQVINSIKKMVDVGTPINLEVLGQSVVCAVIKHYLLELPLPLFSNDYYNMFEKVIEKPETEQKSSLMIVIQKIPIINLKIFVQILKLITHFTQIDKLTNSTISIISLFGSLIFQKESTETIEFIMFLACQNMKNIENYLKQMIEKSNQKKEIKSQNMNQKQKEILENDKIIATLLLKKEIDLVSNEKKQLSQKYQSKKFEIEEEIQQINKINGIYEEMNENFENQKEDQIVGKNYQILQKNGKIKKKKHLKTFHYWKLNMKRKSREILRLEKRREEIAFEMKDILKKTQKSKFEKSKIQQELSTFEKQLQIEYLKVETEQKLNESRKSQFDLFMKAFQEERERFTNLKLMKNEEMNKLSQDFTKFLEISSNSQELFETIEKIENYKIDLRNYIKIIEKQRNQSKLIEKMLIEKGLISKDDLKSNETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R998</accession>
    <name>A0A9Q0R998_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R998"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="605" mass="71327" checksum="402B78A01833BCA3" modified="2023-09-13" version="1">MEGIIEKMKSKYSRTKSLSYELLSTIFNPNLDQDIILKSKIGNEKKSDSGKKLYLFSTILKSRSPGFEAKIKEKQMELELEYNYYAVKTVVEYLYTGSFAIPIKHPENESLDPFKLASDLYSFCCEYSISELITKSEKYLLAELQRDDPSLVQNQSNFKNKMLNRFKDIQKLEGVSKNIRQEESIVEKFLRVIDKNFKRIVLDCDYLHLDDLNLGKILERDTLDVENELEIFYLVIDYSEQVYQKKMESTKTRKSTSKEKDSKEKDSKEKDLKEDLKEDLKEDEQIILTENTKENLRSNLIKRVRFGAMNLNELQIVNDFQILTNEELNDISNFIENEIDEDYEENEQIIQDYKARGFDWFKPKRMYFDHEYCNSFQKLVKSPYEKVTITQKQIDDCLLGQYKKILEPWMKNDSLQKMKFRFISTKDHNLNCRDFHEICDNKGPVIVFIESEGSVFGGYTSVGWKKTENQNQNENPNQNQNQNQNSNQNQNQNPNQNQNHDQIQSIEDEEAFLFILKSQKENNKQEMIPLIPEKKNSALVYYSQRGPIFGDGWDLSVSGDLKTFYANPGFTYRLPGNIQYRSKKAKMFFTGTYNEGLIQRFEVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9C2</accession>
    <name>A0A9Q0R9C2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9C2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="89" mass="11069" checksum="6DE69B54C7D996DD" modified="2023-09-13" version="1">MFLREKDEILCRINCMKRKDFQFVIRLLFRKFSREISVKVDLSLERFFEVLRFLMKSISEEIEDERGFEKDEMKMKQSQTDYLYFSVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9C4</accession>
    <name>A0A9Q0R9C4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GSTDWPA"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="4">
        <location>
            <begin position="655"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1495"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1495"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1519"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1534"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1549"/>
            <end position="1568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1595" mass="188006" checksum="C77F9BE748BC4B3D" modified="2023-09-13" version="1">MEINQEKQSLQNSLDKPAISSNLENVLNQIIGTTKCFIDSQTSLIIQAEIEKLKQEQRIHLIPVKLIISLFDDLIVSIDKIEEELKIDNFLKTSNNSNSISNSNSISNSNLDSNSKLDSNSNLNLDSNSNLDFSQNNLSNWLKGLDWILIILKIMNSDKINYQIYQEEYLVKIVKFIENTIKLFIFPFSKNKYEDPIKNQMKQIVNKMCILIEEIHGLIINSYLTDEILLKISTFTLSLFLTPQIKKQLRYLSISILREIFTRYESHRMHIFQELFSEISTQNSDAILRSKNDLNISMLNESFIQLFTALILQLIQCCSGVPKIKKSKNKNMKKSTEKQPKEQNPLEEKNNTERDIQKEMIIRSLKNKYKTKNTYGSCLTNSRRFAQLFLDKISTKNEKQKIFEKLLELFIDDLLRALNQPEWPSAELLLDVFTSMILQLFENSQQKQLKKALLIHFLSRIYMGITQHTLFMKENRNQIEEKGEKMRELLNKDGSNFTFQIAIQKTILDHLLKIIPKEASVIYSYRFFVSKWFDENEDLRVREFYRYEWKKTTKKQMLMNNHFQKSGDDLKNLQNIERQDIRSFCLYLSSTRPLFANYGKIINILISQIASKKQKTRHQAVKGICLILQKEPQLLAKQTVFSPIISQRLYDPSPLIRCEILSLIGTLIFNKTELFELYYQRFVERILDKSVIVRKKVISILHNFIKKQFFHKKIFQIIQILVKRLEDDDEKIQEIVSNILQELWFETRIEESYQVEESIISKDFDENFENELEKFSGLIENKVLIQRFAQIIHCIPLSISSINLRSVDVHPFKHQWLVELIQSSKKKDETSTTLICKDYLKLLFHEIQLIFSPSFRFRHSVISRNLQINLRVYVNNIVALLGVLSKVFPHFLLPKFQFLCSYIPSNTFGMNSVNLDFLKKIIIVIDGVLSEVANDSMINSDILLDLENKLYFIVFSTETEIARVSLQCLCKLEKKILKNYHHLASILSKFVLYLDFQLEFIENSKSNQLIENDEKTIIINNNNNNLYLNEKNQNIAKYLFLSGILYRSFNFQKYKTSFDFSIPMTQLLSKHSSIDNILYSIFKQFFEKNIFDRDIQIKALNSLGNIFISNPKFESQLVQLISQIFEESKNDYDQRERIQVIQILLKMIEKENKAINKLQDQEDKMNENENENENENISAFAKIHKSAQILQKYLEQIIHLCFSENSNLRYLVLHLLNKIYQVGYIHPFKFVSIFVGFLFENTARNSEFSFQILCNLHKRHPKLIQERIIEGIITGYKLNPTFQKKESNYSFGSFSRLYELIIESSNGSMNQILNGIMDKFVFDEIVDLPVQDLFFYKYLVYLVANLPFTRIDEPLFIINRINRIVSLKGDLIVSELKKYFLKKKNKNGNDPKMFVNVQLALLLSILLLLKKYLITVYGIPIQKCENYLEMSKSSNSSLIRKVKQDLIFDTNLLKLSNENCGKFWMKREFEKFYKLMKEDEEGEYLFESIKKEEKEKEKEKEKEKEKKKKRKKEEELKRSRNRRIRTKRKIVNESNDESYESYETESNESSDSNDSNESYKSDSNYESDSNYESESSESNESYKSESNESYESDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9D4</accession>
    <name>A0A9Q0R9D4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beach domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="2532"/>
            <end position="2640"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="2648"/>
            <end position="2939"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3129"/>
            <end position="3170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1633"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1877"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1996"/>
            <end position="2045"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="875"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1640"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2005"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2019"/>
            <end position="2038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3304" mass="388130" checksum="EFB47C9C48FD96C7" modified="2023-09-13" version="1">MEIFQLHSLWNNFLKSQNPQTQKNHLKNFLQQFILKFENQNKQLIELQFGETSTLYNLIFKIFYSKLNLFLSSRKNIKTEILYDKFLSKNLIHLLLKTLSILPITQENPCLESYPTAFINLLLSSSKSQIFTNLKHQKNIFVKGYHFPKFKSLVNKPFPPFVEFESLAKSFRNKQKRKAVDDSKTSFKKNSNQNKFKTQNSIIFIIEILNNLLQNPKALSQMMEPRNLLALLHIIFLDLPSQIIRYLLRIFFIPFKNTLLQVPQSKIHYKISFIEHLLYIVEENFNSEPKLSVVVDIFELILVLLHQQSKWSLIFFNEFEQNFGLKTLFESIVFIGNLQNLSKRKKYLLKTINCLAQFVFLGSSKLIKSSQSGEPTNLECDKNSLFTQIISLTSMMTPKFSSSPFDDEDFTQNPKINDLLLELQIKEKLYKVVRNFDAFQIILDIYFPDSFNWGIEGFLLRVIEIILTEHPANFLFLQDTNVLNFLFKVFPKLDSENQDKTLKILEFVLFHYDLSTQLFGYCRVLLNENPQIVRKVSEHMISLILQYPSFDDKLQEAGVIEVISSILKKILKQKFSDQDQDQDENDENDENDQNNENNQNNQNNQNNENNQNKDDDPNSSQIKTKFIEFNSGDYSVFHLIALLLKNNQQNRIKFQSVQGFQMLYDLVSSSKTRWSLLKVIIEVCIHSSKQESEKIFEDLLMLLQLSGSSSSLERNLLLTRIDILASLTILFRELPHLKNNFNIGFFWAFSVIHVIGKSIKLEKEKIVNLDENLKQNARREIEYSAFMIIDVLFRTMIVVLKDNIENQKLFINELQFQSLYESIELTKLFYSPFAELLAETFLNLSVGGGIKPKIRNLDPFNKYNNPNPNQNQLQIQNQIQNQNQFENQKENQNQIQNQKENQIQIQNQKENLNDNNKNNNFDPQNIYSEILNKISFDSESNPFISITEIAFPSYPLRDPHSKFVVKYPDIIKLLLLLLSKPMEKQAIQMNVVENVLDDIIYLIENFEVNSKHLSSQRIISHILNQFKWIIEDERLTQICKHQIIPSYVRKILVEDKKKTGIIEFPISEKISFSSKGFSFYFWFNPTQRAIDSLNKNNFKSIQLLSFHDLNSSAFIRIFFTYQKKIYLEMFDQKYCILFKTFQFKPDYWYQVSLIFEFKKESQLSIDFFVNGNHIKSYTINISFENELKKCKLISVGGGFFFLKNPHSDIETSQFQFVDFHDPKNQKEKFLFTESTITLQERANSTQKSLNTSQRKLTPIKSQKRYWLFSSLFVFSEPLNAKKVLSLYLVGPNYTKTFEKSLENHIYYHFINSHNYKKVAHYFANGLCKLSDYELAEIRNSLIFVYTANTPIALISIKGPIIHDSQSDLLTSFYNQRENSNEYVQTKRFCHGCDSVISLGGIKLILYFISTCLFRKPKFQIESLHLLHTFISRILFNNQHDFLGMDVFLLLKRLLENNLWIVNMETLSICFKICGISKNQKLHRVNLEDVYLKSDENNENIFDENNNENDGNELFNIGIIKNINAFNHLIINWKIWKRAPDNVKISLFSSLYSLISSNDEVAKFNISIFRSANFLTKILQILDQDLTFPTSLLSSVMKIIEIIAIKSRDVEKIFNFILLFHYEESFIIQQSKSNSDSTNLNKNENTNENINENTNENTNENEIKIEIEIENIQPQRKYYIPYHGSNDESKQRIFLKELKPYQSQSQIFLIRTLSNLIRKNMIQKKNTNEFLDNLDPKFFYPLLSHNAEEVRIELVKLMKEFLKSPSFRSRFLHKKGCYLVTHYLKKKPYSLALVDEMFGSLLITQKVSPILLGMIIYSDEFAIKNHILKTIKDLYQKNESLQISFMEIELVYTIVDIVIHEEFMNENESMNEQISVSIKEQNSSVEIETDEKSEDDSKNRNHKRSDLGNKFLLNIKQGLKTDIEKEAFAFLISICENAIQVPNGFQNVVSRIVFVFGSRNFEIPTLKVRFLQQFILISVGDLFLKINGILVMDSKEKEKEKENQNQKENQNQNENENQNENEKEKENQKENQNQNEKENQNQNQNQNQNEKKEIFFDNFIEFVQLSTNLIIFWTEKEFSFADKTSYPVDFDMFFIQSILRIFTEFEKSELYPIEKRRVVLNQIINIIIYFINLSKFPILQNSVINFAAGHPNILLSIRLHEQFALTFLYHVISAFINSLHDEKIQQKIQFLYNYLIRDEKITEILNEKITKNPPNTPITIEKIDLPSLQSMIKTSFNTLHERYENQKKNFYDDYLFFTQNPQQNQNSYRQYFGQEIAESQEMFDSKFYKLSFGRIAELEKSILLEKEIPKKWEEIIYWSQEEGSVWKNESFLTLFFLDDAECTQRKRMRIRKLFLNLGDDISSHDVKFNSPFIFRKTKSNDLQIENEIEIENQNQNQNQKNESENFRDEEEKLRVTVKIKIQAKNIREINYINKFDLEPETTHYVSVKIGFVSSLKDKNYSSENDSCSSNEKIKFQNKRNMKKLRKQELKQGEDQELYSSRIMKEINDIPIPTLRPEFEQLARYFIKKKYYIPTNETKKKIFHCKLITIYTDSIVKLIFTDKGIHLFIKKLMKKEGEFSLDLFKKVARNHFKIGYQEIEQIHRIKYLLKDIAVEIFLTSGRTMFFAFENREKREEIIEEIFKNTLENYFDYEQEYSVSKIQKLWIKDKMSNFEYLMHLNTLAGRSANDLAQYPVFPNVIADYNSEVLDITNESTFRNVSKPMGALDHERMQRFVSKYNDLKETGTMPFHYGTHYSNIGSVLGFLVRLEPFASLLIDFQSGQFDLPDRLFDSMERNWKMSSSLSNVDIKELIPEFFYLPDCLTNLNGFDFGKKQNGVRVDDVVLPKWANNDPRLFVHKQLMALESNYISINLNKWIDLIFGFKQRGQAAVDSVNVFHPNTYQGITDFELIQDDNERQGVIKMLKNFGQTPKQLFKSLHQSKSKFKKIQREMERKQSSSRSLLKIEEIDVNNQTENPINQSFNEFDEKISENIITNEKITDLKKTIQDTTHHLLKRVIYQNPSSYRAFGFKIGQLFLLGNRIIAVSQNQCIIYPMKTIYSTWKNTDQTLRIYTLDEELVFFADNPFDDHIICCDSSTKEKILVTGGSKCFLTIWQMVAIENKFINMYVRNILYGHTQPILCVVCSSDFHIIVSGSADKTAIIWDLNDFSCLYKLDGCDGPISTIAINKSNGDILTFDSCSNSQKKINSLKLWTINGRLIKKVELEEQELVKSAVFTNGNVGVFQNVVLTGMYSGKIFAWDSFDLSFICCFKTTHNSPVTALFVTDTLENMYSGDENGNCFQWNLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA88</accession>
    <name>A0A9Q0RA88_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inositol 5-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA88"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF291">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="521" mass="60569" checksum="AB2DA8FFB691AF6D" modified="2023-09-13" version="1">MNINEFTREGFLKKRGGSYKSWKKRWCSLHENKLFYYEKQEHSNMKNHIPKGFIYLEDCSISVKSLEKNQFEICVRDKKRKYLIEANSNDEMMEWILAIFIHRDQYYFAQIGAMTPTRDENYRRNSFNLPQIFNVEQFVTFEVQKIEKTKKKPFRCFVISKEDGTIGIGKGNMKKRSKTVTKAITKSGNTFGSLQDAFQFYQKFNPENLIRFERAVSDKTKIRLMWDVKGHFNDYIFTSGVARERFINEITQIKVQCLGKKELALLYENIKIKLFIGTWNIGSAAPPDDLSDWIPNNQDIDIFAIATQECDYSPRQGYSNTQDDWTVTLSMHLGTKYTLIAKQSLMGIKLHVFIKEIYIKHVHCIQTETKATGVAGVVGNKGACGVAFQLHDSSFCFVGSHLAAREERIAIRAENYRDIIGGLHFGIPGVDITEQFQYLFWFGDLNYRCEYPFDVGVELGMKKDYQKLLEKDQLKREMSQGKVFQGFSEGKIDFPPSYRYTRGEVNIFSDQPQILVLPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAT0</accession>
    <name>A0A9Q0RAT0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glomulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAT0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="349" mass="40889" checksum="627DA4785DCBC0CC" modified="2023-09-13" version="1">MILIKSTKINIEDTLAHLEKYYPSQPQNIKNNNEENTKSSNQLISNSTEELPPWPLLGISHLFYLIYIQDFKYENFFTSKIKQIDLFTILKLVKPLIVSSDPKEVTEISYSKGMTLLFFGLLQTKGESFDAKIFEENKTQFVEIFKLIANNLLGCRSQEEFSSLKGLFEHFFSLFKVEVAIPFILDLIVSTPFQMILALLISLLQFALTVILREHFLNQKSFDDHLFNRLLSTCSFLLNMKDKPDVENWIDFIMSVANFYRFLLTIDLQNDHFFGFWKKQFHEEIQLIFFEPLFKNIPITINDLKEDIKIAKESEKDHLLAIQAKFDLLLSTVQMLSDFIKENIDNIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAU3</accession>
    <name>A0A9Q0RAU3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAU3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040368793" description="Fibronectin type-III domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="460"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="900" mass="101217" checksum="34FF4166B85FF512" modified="2023-09-13" version="1">MKSNIFFFFLIINIFLIQSIQTQPKSISSLISTIQAEIGTTRYYSTPDEGWFWSLINNYSGSGYFGNSVSVYEDVLVIGAEGVAQVFVYRYNGTNFELEQNIYQPGTHFGWSVSVYKDALVIGNRLDAYKVDVYRYNGTYWNEEQMISQVAGQFGYFVSIYENVTVVGTYADTRVFVYRYNGTFWNQEQIITKSVTNFGSSVSVYDDVIAVGTYQTSQAFVYRYNGTFWNEEQSFSVALSWFGHSVSVYGNALAIGAAGPKQAYIYRYNETYWNQEQIINGPGSSSFGWSLSVYNDSLVVGAIDTKQGFIYRYNGTFWNEVQVFTQSSVTDFGYSVSIYKNFTAIGSQHGEQGFIYQHYLIPQVNILNCSSFFSSFDCYWDETEIPPTLKYQINYGYDWIDIDSPILEDGNVYYQQFNSSIYDNITGNEYYSIQIRACYNETMSCGEPSSSINLTTRIDSVKDFQLSNPSDYSINANWDYPNVQVDEGVAHLDHYNLSYFNQSDPDSISFFSVDNSSLSYLLENINCGYDYNISIWGCRTLECEGDDKGEVCESSISILFAQVPNLSCSISNLLDIDCSWDQPINCSIPDYYNFTYQAISQDDSGNYQSNSTNQHFKAQFPNQEYQINVSACPSNGNCGDITTTSITTGNLIAPTIYETIPKIEEIEFNFTKVSNANNYSISLDNGTNWQNFTSLDLSGNEVIGTLSEIAGNVQYNISIRGCVDSDCEPQYFGLPSSITSTRVILGNITSLNCSALPFGFECNWDALVLSSGLQAYSFNYNSTTICLTNLTTSVSISLLLPEEYYEISVYSSADENCLGSEYSGINSTTSITTSNLEVPTIYETIPKIEEIELNFTKVSNANNYSISLDNGTNWQNFTSLDLSGNEIQIVNLNISDCQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBL8</accession>
    <name>A0A9Q0RBL8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBL8"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="266"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="486"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="591" mass="69104" checksum="92018619239C169F" modified="2023-09-13" version="1">MNEIIFFGDNQYPKLFKNEPEKIKSIQFNFENENENENENEKQIKQISSGLFSTIFLFENERAIEYLNEKDSKQNPSKIQIEENIQKVSVGFQNEAILTKEGNVFAKGKDISSNNSNEFINISSLIEDLDDIVIEDVVSGIFSIYLLTSNQNAYGIGDNSYGQLGVDSKTLKETEKPILMMKNVSKIFSGNFSHRVFLLNSNQELFGCGLNRYGQIGLGESSKEETIYKLTKIQNIPKGKIIDIQCGNFHSIMLIENEDENQNPKRKLYSCGYYEFNGLGKTENTYEFTEIKLSLFENDIIIDFSVGNNHTLILTSNSNLIGFGNNEYGQLGTEDRKSQLIPIQIELPKLRFNEDIFNYHVLCGYYRSFLYYSPLSFSNLEEDLIKLFKRKEFCDISFKTENGEIIEAHKLILKYRLNQNENQIEKLKEIISNKSIKESNQIFEMIYSNRILNPKLYFEIKEIINSNEKIEETMKRIYLNENENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIKITQEIIDEIERGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBS9</accession>
    <name>A0A9Q0RBS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBS9"/>
    <dbReference type="OrthoDB" id="6678352at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040122929" evidence="4">
        <location>
            <begin position="19"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="6">
        <location>
            <begin position="39"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="536"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="809"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="999" mass="114252" checksum="2B81C3944562BF8C" modified="2023-09-13" version="1">MNNLIFLLFIFFAIQTNEQTCETGRITRYTVGSSGGHQAGTCGFGPVYNDVALFKDNLIVAASQDFYNGFHTNLDFSTTCITQNLVSCGLRCGECVEITGTKGSFPFIVADICDYNAVGEECGQSTTQFDISEFGQTSGEEYWRCLADSLGYEEATYKIIPCPTEGNIGFYMPESGSNSYSVAFTPYNYKVGISKMEKIGAGNGVNTPNDWMELPRSWTNKFEWRGAGSQQIPGQSGAIENGGTGFRLRITSLYDEVIESDIITIPSQNPQDYRYSFNAQFTQTQAYPLGCPWSGPSRKIYDESVEVRNTRLYFEGNVWLTEWWFVTQWGLPNINFEYSTSCSSGSHCIYTGSADTSAGFIIGSSAEFNFNAFTSLTFKARTVSGTYSSLSLVWDDCSTYYYAGEITSSWQTFTIPMDQIACGSKAKNLKFLVNGCSGLVLDQISLVYDGSSPTGSNLADCVYPPSSPQTDSSSSSNTGKIVGGVFAALIAVSLIVFVIVSYKKNNSKKLSNDLKNLFQNQNQNENQKQKKEESYFDFEIICEQNKISFKTHKSILSSRSEYFKSLFDSKMKENKENKLILKDVPSSILFSILNYFYSGKIEINLENAIQILIFSSKYLINELIEICLNFIKNNLQFETIIDVLKLSETMNLNQLLDSSYKFILENFEKFIKTSFFLELEENHLNFILLNDFIPINEFEMFQSIIEWGKHKSNINQEKVGKKEKEKLQNQISNIIHKIRFIDFTKQEIEDTFKEDLIPNQIFQKLIQFLILKDQENEKELNEFIEKENQNQNQNQNSFIFKSRFRFNSQIIKEKEHFKKLKEWINDDEFFSKMKKGYSRKRDGFDSKKWHSICDNKGKTLIIIKTTNNFIFGGFTQVGFTNDKSKWRKEDSNKIYGYIKDPNAFIFSLRNDKNDRNPEKFPIKKDQEENALFFYPSMSGPTFGNGADFCLNANLQTGYSDFGESYNLPYEIRRNTYESKSYLAGSYNEWIVDELETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBW1</accession>
    <name>A0A9Q0RBW1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protease s28 pro-x carboxypeptidase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBW1"/>
    <dbReference type="OMA" id="NDYIDSQ"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040446863" evidence="6">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="437" mass="49776" checksum="4C7154A60F3841C4" modified="2023-09-13" version="1">MKLFFAFFFVLFVFYVSAGYVNLTMNQKLDHFNYLDDRTFKQHYVVNADYYQPGGPVFLDITGEAPLEYFIKTYGFPIELASKYNALFVSLEHRYYGTSHPFPNNPTNEQMTYLSSQQQLADLAAFHDLIMDQFNLPENTTWIAFGCSYAGMLSAWFRMKYPHMIAGSYSGSSPVHAKIDFFEYNLVCQEALDPSCLASLNQALTDVKTLLQTPDGQLQLQQMFNVCTPFTDNFQIVSFEYSIVDYFQGVIQYNNPPNYPKETMCQILTSAPDPLQAYAELVVSDSNGNCIDLSSNGLKSVASGGNSWWWQCLTEFGFYQTFLANESFGFPDINVEYYQEINNIVFGITMDPDADFINQFFGSTDPKDVTNIIFTNSKYDPFLRNISDTVTSYVYTSAGHCAPFHFFNSEMQQDVIDARNAIDEFVQNIISSSKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC02</accession>
    <name>A0A9Q0RC02_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nad kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_07989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC02"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="609"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="651"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5074634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="776" mass="91171" checksum="2C65EF7E4CFDD6C6" modified="2023-09-13" version="1">MSSGFKFGLKCRRPTTGFEDDHVEMTIDNSQLTNQFWGNKAMRLFWNTRMKTVLVIKKRNDARAKRKALKIINYLLSEKFEVLIEPSAQDDFPDIPAYKEKDAKNLNKIVDLVVCLGGDGTILHVSSLFYHQLVPPVIAFNLGTLGFLAEFDIKHFRNYLQSVTHGEFYITLRARLSCRAYSKKKNKYKEYEALNEIVVDRGPEPFLANLECYCDNRCFTTVQGDGIIISTPTGSTAYSLSAGGSMVHPTVPGILFTPICPHTLSNRPLIFPENATITIKLPQNSRGAAYTSIDGRQGIKLNQGDYVDIRTNFYPFLSVNKTDAISDWFVGLSCILHWNDTITQKVLHTEANLERFQSNVPVLEYPVDASESSEQKKLEVIQNDDEKQKIEKNKFLLKKQKNRFVIKKDDTEEIIEEQDEKIEFILKKEDNEEIIEEKDEKKDIIITKYYKQELIKEDKQQINDKQQINDKKQINDKQQIKDKQQINDKQQINDKQQINDKQQINDKQQINDKQQINDKQQINDKQQINDKQQINDKQQIIDKQQINDKQQINDKQQIIDKKDDKQQINDKQQINDKQQINDKKEINDKQQIIDKKEINDKQIIDKQQINDKQQINDKKQINDKKDDKKEINDKQQIDDKQQINDKKQINDKQQINDKQQINDKQQINDKQQINDKQQINDKQQIDDKKQINDKKQINDKQQIIDKKQINDKQIDDKQQINDKQQINDKQQINDKKDDKQQINDKQQINDKQQINDKKDYIKDDIKDDIKQIIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCI4</accession>
    <name>A0A9Q0RCI4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein WDR12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_01224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCI4"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="409"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5074593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="488" mass="56821" checksum="404FBB906D241271" modified="2023-09-13" version="1">MEIENETEEKKQTETVQVIFTTKYKEYQVIETPFEIPVSLTRYGLSEVINHLLGKEKPIPFEFLINEEFLRTSLKQFLDEKNLSSEKQVTLEYVPALPQPKQFNQFLHDDWVSAVDGKNSFNIFATGCYDNLVRIWKSGLYKLKGNEIEEKKPIHVNLNQNQNQNQEQPSLILSHHSKPIKSVKWLKFNENISNQKYHLLLSASLDEQIILWKISSNLNSYSILTKFIGHSEGINDIALNPKRNLFCSCGNDSLCFIWDINDKKNEYQNQEENQEENQNENQNENKIIENNTPIASLRGHTQAVSAAIWPSQSSIYTTSYDYTIKKWDVEKQSLVWEAFSKNTIHCLHYNQYEYPYLNFESNQNQNQNQNQTRKESELLLTGHSDGIIRLWDNRIPSNSEESCVIKTLFKSHTSWISSLKWKPNSDFVFASGSYDGSVKIWDIRTKIPLFTLKRNSEKILDIDWLDSQNLLTASADQTVKQIILKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDE2</accession>
    <name>A0A9Q0RDE2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gtp-binding protein engb-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDE2"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="584"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="645" mass="75238" checksum="A00980E155F067E5" modified="2023-09-13" version="1">MNPKQQRNLPNEQFNSNHPSNKKPLSRSRQPPPKFPNRNPPNNQNNQQIKTRTPPQNNQNNQNNRNNQNNQNNQNNQIHRIQEQPQNPEYSNEHFMIAKISTQKKPNEISNVISFTGNTHSGKSTLINALLTSNKFNGKTGNVGISPKIGIETNLAMPPTTGNLWVIDDPNNNNYRYLDFEGNSAGSRVPIDIDIETKNFLKENKIKEQKYAKKRRKSVEEHFPRLSYLVSNVIVYISTLDFADNIYYSELLKIAKKSTKKVQSAEKPALILVKNKYPENPELLRWYSEVHCVSLPNFDIEEPNSIEIFQKEIERLKELINQVIEKQNQNKKKLGILYNQFIWIILFELVVKKFQENIRMSSILSRCLLYDLEEALYSFRFFEMIMKEMSLEDYLLSEKNAIKHLAITFVVQEIENLIKINMNATPLLDYQKKGMEFFDKLYPQLLNQQPCQSIQSNFRNLSQKEQKKIPKEGIQCSFTRGNHTQEHCNTDYYFDRDGKFRRKIKSAFSKAKPISWKGNFQFPETETQSKKIFSETILNFREFIEKSNNLQNSLQQIYLQYAILNKEINDHDHTLRSYLPSDTCTICFHPAQEKRLTCGHLVCGKCIEIFGNLPDLIESNLNNETIQNPIGFCSYCKDKVGVQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDG3</accession>
    <name>A0A9Q0RDG3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor i-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDG3"/>
    <dbReference type="OMA" id="IWEELTH"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF366">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="339"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="498"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="736" mass="89040" checksum="D6A97BBE8FBCC2AD" modified="2023-09-13" version="1">MDQLKNLKNKKKRSYKRTNLTRTTSQTLTEKEQTDKEEERIRKELEEKERIRKELEEKERIRKQQEEEEERIRKQKEEEERIRKQQEEEEERIRKQKEEEERIRKQEEEEERIRKQKEEEERIRKQQQQQEEERIRKQKEEEERIRKQEEEERIRKQKEEEERIRKQQQQKEEERIRKQKEEERIRKEEEERIRKQKEEEERIKKQEEERIKKEKEEEEIIKKQQQQEEKMQKELEKDEHKENTNENDTENPNQNVEKITLQAPPSPRVLPPPPKNLPPPPVNPKLQKEEEKIQEKKEKVINYDEKPHLRFETEEEESLDDVYIWKEPNDSESNILLADKSEIKAANLNKLIEKLTSQQNYGVTLDTFLMTYQSFTTPKKLLTKLIQRYHVPKTQNENEDEYAKRKKVIQIKVINVCTKWIENHFSDFTEKILKELHEFIDQTLAQDDKLIAKKLRDTVIKKQKGIDKKKIIHESENIPEPKVPKNIFNSSLSLLDVDEEEIARQLTLVEFDIFSQIKPSELLNQAWSKPKLRHRAKNVLAMIQRFNDLSGWVSTTIINCDKLKHRVRVLTRFLKILEFCRQLNNFNAVMALLAGFNSSAIYRLKFTWGEIPRRQIEVFDQLEKEMSSDSSYKGYREALKGVNPPCIPYLGVHLTDLTFIEDGNPDFIGNLINFSKRLQISKVIRNIQQYQQKGYELQPVHQIQQLLIKFKNLGETETYDKSLKIEPRNADIEDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REH1</accession>
    <name>A0A9Q0REH1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REH1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="155" mass="18865" checksum="C9D0E8AB491B656A" modified="2023-09-13" version="1">MNTYFHKSSQNISPFYFKHKEIKMENFTTKKKQELINKEQELMKEKQELMKEKQELINKEQKLINKEQELMKEKQELMKEKQELINKEQELMKEKESNNVEIEKELKLLDDEFNKSDYTDEATLLHYFAQKEPINKGLFNHFINSGADWNKQDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REW0</accession>
    <name>A0A9Q0REW0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REW0"/>
    <dbReference type="OMA" id="QDEEVPF"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="269" mass="32884" checksum="ACEF406415A05DFE" modified="2023-09-13" version="1">MGGSMKRMKLSKKMSNQKRRRKKRFKEKENKINKEKENQTNKEKENQTNKENPFQNQELEHFMKRKKMEQKEKENQIENQIENKNQIENQNQNQNQNKNQNQNQNQNQNQNQNQNQNQNKNKNENKNQKVEQNQNKNQIENKNQNQNQNQNQNENQNENQNQNQNQNKNENQNKNQNHNLQNNNNLNIQNLDSIWNFLSNKKINENFEEKNIQNENIFIKRKNESTQTEKEKEKENEENKQIKKENEELKKLIQKQNIIIQTIFMSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF30</accession>
    <name>A0A9Q0RF30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF30"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="488"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="593" mass="69020" checksum="ACC2F75DF8ED1185" modified="2023-09-13" version="1">MNESIFFGRNQYPKFLKNEPDEITKPIQFKFENENENENENEKQIKQISSGLFSTIFLFENGKAIEYLKENDSNQNPEKIQIEEDIQKVTVGFSNETILTTEGNVFAKGYDINPRNPNEFINISSLIEDKNDRIVRDVVSIYSSIYLLTSNQNAYGIGDNYFGQLGFDSETLPKTEKPILMMKNVSKIFSGNSSNCIFLLNSNQELFGCGYNYSGQLGLGESIKETEIQKLTKIQNIPKGKIIDIQGGFNHSIMLIENEDQNENPKRKLYSCGDYQYNGLGKHEDTHEFTEIKSSLFENDDDILDFSVGNTHNLILTSNSKLIIFGDNEFGQLGTGDTNNQFIPIQIELPKLRFNENISNYHISCGFNKSFLYYSPSLSPFSNLEEDLIKLLRRKGFCNISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLKEIISKKSIQESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDELETGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFN2</accession>
    <name>A0A9Q0RFN2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 14</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Deubiquitinating enzyme 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin thioesterase 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin-specific-processing protease 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_05160</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFN2"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052476">
        <property type="entry name" value="UBAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46738">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46738:SF1">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5078372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="251" mass="29214" checksum="76C0FF69F24EF787" modified="2023-09-13" version="1">MDININLPVDEEIDLEFLRAKTPPENEQLFEEDELGNEMKLTEKIPVADENIVSQLELFGFPKNRAEKAALTTQNASTEIALNWLLEHQDDPDIDVPFSFKEKQKDDFVDDPIIIEQLTSMGFSKEQSIFALRQTQNNPDRAVDYLFNHQDDIEMLMIQESTKKQEKSQDDVVFDDDENLCEIENENDKEKKHAKFVLSSFIVHMGSTPQSGHYVAYIKKNDKWILFNDSKVVIDDDPYFGTGYIYFFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG56</accession>
    <name>A0A9Q0RG56_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_05191</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG56"/>
    <dbReference type="OMA" id="HNIESAI"/>
    <dbReference type="OrthoDB" id="70570at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF263">
        <property type="entry name" value="PLECKSTRIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="383"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5078403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="612" mass="70545" checksum="6CA551F0939770B2" modified="2023-09-13" version="1">MSSVSTTSTSDSEVEMTSRELSARKLLQFEKDYLSQLDAFLKFVYEGLSESSRSGDPIISKQNLQTIFHNISEIYQSTTSFLRNYEFRLLTWMNDSEIGDLLVQINPILEQYISYVKNYHFALKTLEECESNKHFVKYCEEMKASPACNGTPFRTYLEMPLKHPILYNKFIQDIYKYTEPNHPDREAISNFLKNLDVKLKKIKSIIQKDKEAEKEKEKDKEKDKVKDSSQKTQKETSRVEEDSIPKLLLRFSGKLPKIDKPGRKFISEYNVMKASRKKNQKRVLFLFNDILLVAGPHKVLKRKLTLHRLLSLEATKIVDISDSKIVKNAVGLKGPGKSFTLFADSPENKKKIYSSIFEQIHITMKEKGIDPSKVSEAPIWKQDKEVKLCMICGTKFTLTKRRHHCRNCGNIICNSCSSKKMRLPHISQTLQRVCDYCYNDLNEKSLLAIGETKQEKTETKKPEPGPLKQNRSKRKLPAPPPIAKQNQKETQSNPQTEKTKKNSKHSNNKESKSSKSSSPNETYKNETEKTKKNSSKSKTEIPIQKQEEKKEEKQEETDLNKLLDLITLEDESDGDETETDTDSNSYYYSNSDSESESNENSIDTFDLSTDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGB6</accession>
    <name>A0A9Q0RGB6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGB6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="183"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="429"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="740" mass="88196" checksum="F45CDD947F98BA24" modified="2023-09-13" version="1">MNQNQKRNKDKSKSKKDEKKEEKQKDPKKETKKSGIKKYSKSGIKKDSKKYQETKQESNLENQKEFNKESNLENQKEFIKESNLKNQKEFNKEFNKESKLKNQKEFIKESNLKNQKEFNKEFNKESNLENQKEFNKDSNLKNQKEKEMKKIKKKKNKKLNKKMRKSLEKDFDQLYHSKSDQSKDFSIFVSGKEKKEVEFKVHKSILKCRSPFFEAALNESDTSQMNFRDTTPQSMDAVLKYIYTGNAKFDEQKQDLTGIMKISNKFKLGLLSLILENKIIDSLNSSNVCRVFRESENLDSKKIEEYCLDFIGSNFDKIKKNRTFLVLEEQQLNKIIQEKIKRKEKLEMEMFQIVEDWMIQRVVNFYNNDTINKIEIKRITEKLFSGIHRGFIDDKAFDHLQNSDFFSSNLRKVKEIELGFQEKDMKEKMEENTKKLGLVQQENQNLKSKIKNKEKEKKENQKNIKKLQSELNAIKNEREELKSQLNKKIEILRTEFESKWKKEIEESQLQKQNWEIQKEKMENEIQSMNQMVRDQTYKIDNLESRIEKLKTNSELTENFQGSSIIDNYFYIDTLKEWIQDNNFFNKMRLGFSIKKDTRSNDRLVNKILKKKKTLILVKTTKKNIFGFFTQLGLKSKKKQIKDPKSFLFSLENPKMNLPRKFAFRNRSESHSIYAEENILSFGEDIFISDLEKCSSAKFGMDFSLPEGMKSGTLEAQNYLVSVNEKSEFDIDEIECYFIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGS8</accession>
    <name>A0A9Q0RGS8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGS8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="689"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="750"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1075" mass="124842" checksum="D3E48FA301B2C9A9" modified="2023-09-13" version="1">MNEIIVFGRNQFPKLFKNKPIKIIKPIQFKFENKNENENENENENEKQIKQISSGYFSTIFLFENGKAIEYLNKNDSNQNPSKIQIEENIQKVTVGFQNEAILTIEGNVFAKGKDINPYNPKEFINISSLIEDKNDRIIQDIVSGDSSIYLLTSNQNVYGIGSNEYGQLGFDSKTLYKTQKPILMMKNISKIFSGNTSAHVFLLNSNQELFGCGNNQDGQLGLGLSMKETKIDKLTKIQNIPKGKIIDIQCGYFHSIMMIEDQEKKRKLYSCGDNKYNGFDKNIYEFTEIKSSLFENDDDNILEFSVGNVHTLILTFNSKLIVFGGNDYGELGIGDTTEYQKIPIQIELPKLRFNEDISNYHVLCGFNKSFIYYSPSPFSNLEEDLIKLFGRKEFCDISFKTKNEEIIEAHKLILKYRLNQNQNQIEKLKEIISNKSIKESNQIFEMIYSNNSKINPILYFEIKEIINSNEKIEETMKRIFLNENENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSYFSTIFLFENGKAIEYLSENDSKQNPEKIQIEKNIQKVTVGFQNEAILTIEGNVFAKGKDINPENPNKFINISSLIEDTNDRILEDIVSGDSSIYLLTSNQNVYGIGSNEKGQLGFDSETLYKTEKPILMMKNVSKIFSGNTSAHIFLLNSNQELFGCGYNSYGELGLGKSRKEETIQKLTKIQNIPKGKIIDIQCGWFHSIMLIEDENENPKRKLYSCGDYRYNALGKNENTYEFTEIKSSLFENDNILEFSVGNVHTLILTSNSKLIGFGGNFSSQLGTGDTTNYQLIPIQIEFPKLRFNENISNYHISCGFNKSFIYYSPSFSNLEEDLIKLFRRKEFCDISFKTKNEEIIEAHKLILKYRLNQNENQIEKLKEIISNKSIKESNQIFEMIYSNNSKINSKLYLEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSSNKVTDYSELSNKSFQILEYWIYSNQIKDEIQITQEIIDELETGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI62</accession>
    <name>A0A9Q0RI62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI62"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="224"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="267"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="353"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="356"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="396"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="439"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="482"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="566"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="741" mass="85543" checksum="5B4C5FAAEB015A39" modified="2023-09-13" version="1">MEQIQNQINELQKRMNEKDNQINELQKRMDEKDKQIKELQQNLFNIIQNNYNNNNNNNQNTKPETEKKAENFLKSFLNENQNENQNEKLISIEEIINLINQFPKNEKIQENGCFILEKISTKNEEIQKLKGIEIAKYQGILFILKAINNFPNNQIIQEKSISILANIAFDSQNQIEIKEMKGIEPIIKSIINFPNNRDIQFQGIRCLNNLALNNENQIEIRKLKGIKPIINAMNNFSKDINIQSESCDSLFNISHNGKNKNKIKELNGIEPIIQSMINFPNDEYIQNSGCKALTNISINDENKIQIRELNGIEPIIQSMINFPNDEYIQFNGCEALTNISINKENKNKIKELNGIEPIIQSMINFPNDEDIQNSGCKALSNISINDENKNKIKELNGIEPIIQSMINFPNNRDIQFNGCGALINISINKENKIKIKELNGIEPIIQSMINFPNDEYIQNSGCKALSNISINDENKIQIRELNGIETIIKSMINFPNNKDIQFNACEALTNLSINDENRIKIEELNGIEIIIDVLKSGFYIPEMYYNIFKALSIFSLDEENKIKIRELDGISRITYAMNSWYENEEIQKFGCKIFYNLSTNKENQNKIINEVSHKIIATMNRFPNNEEIQNYGCGILSNITINSDNAYYLKSINGIKPVIKAMISFSNNEQIQEKSFEALFNFSKNSMNLNTILELNGIEMIIKAMINFPKNENIQNQGIQVLMNILDNKEIKKHNKTNQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RIA1</accession>
    <name>A0A9Q0RIA1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_14398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RIA1"/>
    <dbReference type="OMA" id="VMMRPLS"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="6">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="7">
        <location>
            <begin position="334"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="525" mass="58432" checksum="ECA68EE8DFB438AA" modified="2023-09-13" version="1">MSFMITRKFSVSIASRIGKKSLLSKVCKPEDTIKFFEDGQALGWSGFTPVGYPKVVPVTVADYVEKTGKKMKFDLYIGASVGAETEDRWAKLGMINRRWPYQTGKNIANGINTGKIQMGDIHLCNYASNLKFGFFTKERKGKLDLGIIEVTEILPDGGLVLAGSVGAVPEVCDISEKLILELNTSMPSYLGLHDIPPDEVPPNRRPYLISRVDDRIGKLYVPVDTEKIVAIVESTKPDNGRPLSPPDEVSEKIAQNILDFLENEVHAGRAPPDLLPLQSGVGNIANAVVAGLAKGQFRNVKVWTEVLQDTMLDFFDTGKLDFATATALTLSTEGFERLYKNWEEYKQKICLRPQQITNNAEMIRRMGVIGMNTPVEVDIYGHANSTLIGGTRMINGLGGSNDFLRNCYISMMHCPSVRPTKTDPTGITCIVPKAPHIDHTEHDLDVIVTEQGLADLRGLAPRQRAMEIINKCAHPDYKPILTDYFNTAYQHCLKQKAAHEPQILSKVFKMQEYLEKNGTMKVDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RID7</accession>
    <name>A0A9Q0RID7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000002">
        <property type="protein sequence ID" value="KAJ5080758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RID7"/>
    <dbReference type="OMA" id="SELQYWS"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="3">
        <location>
            <begin position="354"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="706" mass="83052" checksum="56FE1F25A41190FC" modified="2023-09-13" version="1">MVVYLFLRDFCSCFAFTITFLIIFIYPTLTTIKKIDLENLEYKSNIKNETGFDNKTEKLFWFIHISDTHLNKFHPETIEKFEYFVSEFIPKINPSFVIHTGDITDAKSTSNLRYKNQQNIEEWIIYKNILEKYNLSSPQKWLDIRGNHDSSAIYDLYDPNNFYYRYSSLTEYLNQTQRNPVNQFLFSFDFGQYQFISLDFNPYPHISSPIGFFSFVSESMLQKLESFLNQTQANQTILFMHHPTFLHQYYPKEFLQFPLNAQNNSIRHLSSKYSILALLNGHIHQKGMYSRLSKNQNSKETLELEVGDLKKKSNFRIFAIDNDVFSFEDFDINDIDFSSQSITSQKSNEKKPKQKALIVVTNPKNARFITYNEPLNLIKKSQYIRVLIFPNNWDNVASVSCYIDGKKNPLEMKQVEKNHPLFVTKWDPQLCCDKGLHNLNIVVKNSNGEIIAEKSHSFSIDGTVKQIKPTYWNAAQKLELYQFIWSLLLFFFFLFVVGLGLVPQIVKFILKKIQIYDKFNQKMSQTIFEKPSFKSYLLLPFNHLIFNIWKYSLIPFKDFIFNFLSGIFLLFGPVSIGKMIGEDFGIAFLWGCYIDSHFISYSLPAYHALVFLSFAYFPSINTQAFASLYHLIQKKNKLYKWISLFLLLVSFFSIIMSLMIFTFVYYQGYLIIGVLTSFSLFWSSLLCLILDFRSLLKIYFSKSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5J6</accession>
    <name>A0A9Q0L5J6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_03412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5J6"/>
    <dbReference type="OMA" id="SHVLYYW"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF112">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="404"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5066079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="606" mass="70036" checksum="478AE6E2A8FE0BEA" modified="2023-09-13" version="1">MSSTSDNEFDFDADVPREQDCQLIYAAEKGDLAKVKELIHEQDADINAADGQGFTALHLCSVEKGSYEVFEYLVKLGANLDLKVGKQKLAPIHYAAITGDVRKIHLLVSNGAKPDIQNIDGLNALHMAAQEGYILACHYLLNSEYTRDHLHVNMGDTANTTPLHWASYTGKIDTVFYLLKNGASVDAVDIYGRTALHIACSQNHYEIVQQLVIHGSDLSVKNNEEKTPLASAQEKNYNEIVFYLIHIINGYGPSGIAGKLRDRKLVPYKKLISLGSFLSPLASFLLLFLLFYIFHFIIASIASGFLIRYFYYKSFWPKSYGINSRSYWEAGAAFACIFLTFVTWLFHLLESFFYDQKFYSIFLFFCGLGIFVLQYLVYSLDPGYITADKLTTSQFIYEIEDGMDARSFCSTCHIRRPLRSKHDKVANKCVSKYDHWCPWTYSPIGINTEAYLFFFLFLVVFSTLNFYFYAFKYLSISEQIPPFKSIFKFILAFYQKEKWLFFIFTMNIAFLYFEVTLLIERIIHIAKNLTINETLNLYKYRYFFDSNGLFSNPFDLGYRLNTLQFFKFSNQVNWSQMKKLSDIPVHCRNPKRSFETDSRNILNKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5M0</accession>
    <name>A0A9Q0L5M0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_03081</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5M0"/>
    <dbReference type="OMA" id="SMGTFGE"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="272"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5066737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="394" mass="41558" checksum="E10DA3E54517FF2E" modified="2023-09-13" version="1">MSQAYIISAKRTPIGGFNGTLSSLSSVELGIHAMKAVMKNVGLKGDEFDHVFMGNVIPTGLGQAPTKQAALGAGISTKVPCTGVNKVCASGMMAVILGAQMIKLGEANCILSGGMESMTNIPYHIPKARFGHRMGDGAIIDGMLYDGLTDPFEKVSMGLAGEKCAEICKLTRKDIDDYAVQSYERSIKATKEGLFFDEIEPIEVKKNKKAKPQIINVDDEVVRTKDPQALRKLRPAFTKNGLMTAGNSSTISDGAAALVLVSESMLKTLKVKPIARILGYGAGAQEPMLFTTSPAIALRAALKHANLPIDSVDYHEINEAFAVVPLANQKILSIPNDRLNVFGGAVSLGHPIGASGARIIVTLLNILKKKKGKIGAATICNGGGGASSIIIELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6B5</accession>
    <name>A0A9Q0L6B5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beach domain-containing protein lvsc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="2721"/>
            <end position="2857"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="2870"/>
            <end position="3159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3401"/>
            <end position="3434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3447"/>
            <end position="3488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2586"/>
            <end position="2613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2676"/>
            <end position="2721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2767"/>
            <end position="2796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3308"/>
            <end position="3339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="883"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2022"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2312"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2597"/>
            <end position="2611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2703"/>
            <end position="2715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2782"/>
            <end position="2792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3308"/>
            <end position="3317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3609" mass="427067" checksum="AF7CAEBB2867562E" modified="2023-09-13" version="1">MSLLKNLFKLNLKRIKDQKLFSFYFSTSSNQKKLQELWKERENQQSNKIQSFISFSKLFLNSYSKWDPNLKSFQKNEENFQKNSKKLNNKEEFIKIIQKDLIHPVDLISEVIHYINIFCYEILVKFKFKLDDQEKNKFLEPPLKSKNRIEKIQKESLSFNEYSLNSQFQIGISLEMAKILSKSFYNQDLFLHLNLFDSICYLFEISNNLISKFLEEKIENESTEYCEIYYLVDFIMNSILEIYSNFLESQNEFQNPFFKINKLFNEYQLTENLEILLKNIKEIESKFNVTIQFYDLHLCVLDFFRMINQKYSIPKNQIQSFISLAFSSLKPPPNSLPHFEHLFLFNKTKITKFSKMFNYFENENQNQNQNQNQNQNENQNENENENQNQNRNQNENRNQNQNQNENENQNQNQNQNQNINLINENLIKKDDGSFIDKEFEQKTKFQFHIRSILIQLIENSLEKYPFLLKTIYEFGDFQVITDILLWASITFPSRTFESLKKFKFFNSRNPQNPKKKNKISSNIEIFDTINYKLKIFQKQFKINSYANIVCNPKIEQIFHLLNHIYEIAIQNKSQDKNQTISNSQLVSSRKNKKTEKNIKDSNQIDYGLAICHRIIDSLLNIFNDKYNTTETNQKSRDYILNFNCELQFFVLNFFSDLILRKLLYVHNLKLWNTLFSKYFYYRVNENLKDNQLHPVIFQDLQNFLFQIFYSSFQEGNLSKEQIQVLLQFCHQNHSNIKILLHLLRLLMRVLLLRSNEVTNLIQASGLENVIAQLIQDLHQIHMENIGNKQESFPYHFPTFIKLRYLLLELLNILIENICKEQIFKNPKSAIITFCKILKPLSNLVIEAETRQFALKHIQNILFTIDENLQSDAILIFEEVISLINQLKDKKISILNQNENENENENENENKNENNKNQIKNAQIIQQVLQKISNIIKEKPKPLQYIFIKAGIFDLLISLIQHQNIGNLLVIDVLDLLKSLFHKNRKTPQMFKEKIGSQKFAESILIAENEKPREEIYKILLDMMVGEGEFEMESNFIIQNPEIVTIIFHVFAIKGKDLVPRVMDTFCELCEKSVHNRACCSNVGLISFLVQLIPIFSDNQNTQIKITTLIGIIGSQRVIVKELKLFFSLLKSLPGNFRPPYSALILSAMKQMSQKQEEGPKVFFNFKSKNASLSIPKIPKWPQKGYSFCTWIRFETFQDSFNQKSQLYQHRLFYFYNDKSQGIESLFRTSENEINTNKQQQSTTITTTTTRIPQNTYNDSLIFPLDSNLENNNNSDNYNYNISGINDSITKTKSISTKHTISFVLRISPNVNQTEFIQIPFEIDLRKWYFVSIIHTPSRWSSTAEVKLFLNGKFINSSFLKYPKLQNLSNNIIGNKLDGGESFLGQIGTIYFFNDGLSQTQIEEIYQLGPKYMYSFHPSELNESFGKLWKKFSIFDGELNSKIFLNYNIKASNDIHCFDQSPQVRKDQQDKAKLSGMFKCITASIYDIVYCIGGVKVLFPLIIQLDQPIGTPENINFGKLKEMQNIDYSIDPELSKQIFDIIVDILVHSSSNQEDMVRSDGFAIISFLFKNINSKHITHSIIESTKRLILTVQNSAFLKDLIENFILNYDHWIYSDFEIQKELIDIIKMINSSQKNFNNNNNNNKNNDEQNIDYKVKIQDLIDIIQFYFWKKPQKFSRAKIQEKYHPITREIISKRPNETQIENLRKEYLHLIEVTMNTNYEIGNLFILLRNCFVIKDNDIILNFLEQIQRILLHNFEDYARFFEENHFMDPFIALINFSNQEIGEFCLKILCQLHRQCLIYQREQKITNQSPRNESPSTPSQHSLGKSFGRVQVFLGVVIKLEFTEIVSSLLFFVLTGNDLRIQKIEKQAEAPRINNIYFLQVLFHMIHQSRNEIGVASMKILLWLFKKNKSNRDIVIQQPNWPQIFLYSFSFDALKYSFENQNQNQNLNQNQNENQYTSKINEYIFKLFGLILVPLLLENDIFIQQLEKVLLSIKLFCIKTQKAKDIVTKPFFKSILKIFDKKIKAAIQEELEQIDDQEKNQNQLKLQAISKLKSNPNFFVNFQHLIKFIGYYTLFIEKEVKAKLKTNPILDEFKKKGILIAPLRTSQSFGNDTPKFHEINTRKSRSLSRRNSFSKLVKQKGEDEKEMKRQDFHLEKYYRKISKTKKWEDEDLVIELLNVIKKMNLLEDHFMFQNNHLSENSYNIILQFILILIEKCDELELIQYVQDLQNLLLSLSYSDFVFESMNSKTFAGETKVPQYKRKGILISISKLFKLTISQTINRDFSFGDLKKLFESEKDTFLQQYYQYLAIERERKNQNKIENKIENKIENKIENKIENKIENKIENQNQNQIENKIENKIENKIENKIENKIENKIENKIENQNQNQIENKIENKIENQNQNQIENKIENQNQNKKFLQDQPTKHETIISFIQVIFRDCWPYLADIFQENNGELILKSLEVNSILTSFILYKYHLNENEKWKIILNEKIYPEYPRFIKQRQEEKITQIIEFSEKMENMKINEENEMKEFFLKCGEIQVSIEEWIGRMMNEEKQRIKHNYSEYLRKKGYVQKKWREILRSLTNERGPWGNQNQEQEQEKHWKLDKTEDNSRRRKKMKINYHFDSHFEASIRRDKGTQTEMERLIQEYQEKIKISEKFKSITSGIQMIPEYNAKENQNENENENENTQNSQENDDSSEKHENQLYSQSQQSNQMNTRESTQKKEEVIFHGHFEMIKPLSILKGVLEISGRLMKFYVYSKYESSYSMEKKSSKDEVSENQSIESNETNGNNDINENESEDEFKIPVKIYTWEIDNIQEIYKRRYLLRQSALEFFMIDHTNFFVNFDSDYRDLVFHKIIEMKPENLSFQNIQTSKRIFKQSQVMQQWQRRQLSNFEYLVKLNTIAGRSYNDISQYPIFPWILSNYESENIDLSDPKNYRNLSLPVGALNQKRVIELDQRYNELKNSEIPPFHYGSHYSSSGIVLFYLIRLEPFTTLSIKLQGGKFDWADRLFASIEESWRHSYYEVSDVKELIPEFFYLPEFLYNSNNFDFGKKQSKEKIHDCILPPWAKTAEDFIRINKEALESDYVSEHLNEWIDLIFGYKQRGKAAVEARNVFYYLTYEDMCKIDDIKDPDQRKAIVSQIENFGQTPTQLLTKPHAKRYSRHDILELMYRSTIYRRIKEVMNIQAFVLKVISDPIVFIAISKVDEIVSFLGIPDQVILVDSKRNILINSWVVTNSTSNQKTSEMDSRDFFDLDQDFNDFRTESNKNKIKNQNQNQNQNQNQNQNENLNQNQIQNLNQNQIQNQNQNQNQNQNQNLNSPDLSRKNKPNKTKETQEIPQFTFEPDPLLYKRPKIGVTFDHEIKFFQNCLTTTENQKLLISCGFWDDSFKLTNLENMQLIQSNRKHKDIVTCLKFERGILVTGSRDTTVIIWKFNTKIGQFNQEPINILYGHDDEVNCVDMSINLDVVVSGSKDGTVIIHSLNQGKYVRSIFDPQKNPIDLLSLSSEGHIVMFSEKTSTLSVYSINAKLLCSKKLVSNLTCWTISKDADFLFIGTKQGNIDVLYLHNLKLFHSFALTNSISAITLSENERYLLAGLDNGELIIGYFLFNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6N6</accession>
    <name>A0A9Q0L6N6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centrosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6N6"/>
    <dbReference type="OrthoDB" id="66599at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="1">
        <location>
            <begin position="132"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="396" mass="46095" checksum="C9B6B32192AF2309" modified="2023-09-13" version="1">MNFINFQIFSKENQEDLKNYIFQNISNFGTNSIMNGNGWISKPQSKFPKEMIISFGKEIYCQKIQLLFHEKLIPNLLKISIQSKNSQFEFLGFAKTHDNQENNFLARELRSIYIEKKCLSILIKVEEVEEVELNQTDQKIVNKLLQVFQENDILPLFSKKWITRSQAIKEITQEISEGNQKFPLEILSLLSSRLLKEKVNQVFFESLIFFSKFVENYSQSKFVFFQESIKLICEKLGDSNSRVSVSSIQTLISVCNFIDRTNILRIAIAINLPDQKTQRKPGLSQKPKTRSSSKNVQKNSFLGKFSWKPIFGLLRFIQEFIIKFGIGKEFELIMKCVRLGLLNSKREVRELAVSLCGIIYKLIPITSEKQKEKKLFSYLGKINNLLVNQIKETFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6R4</accession>
    <name>A0A9Q0L6R4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-activated chloride channel regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6R4"/>
    <dbReference type="OMA" id="ICFDATI"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="95"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="456" mass="51617" checksum="9ED13887572228ED" modified="2023-09-13" version="1">MSSCAFHGAKDTTNTRLKIRSRRTPSIPKMTYHGLFFEYYFNAGKIEKQKIFTAEPFCGIVNNLETNEKEYFLSLATKSKYDGEGIQEIGRPKLNCVIVLDISGSMSCSFTGEYHNVESHSSKLEIAKRSLLGLVGHLNDEDNFGVVIFDDDAEELIAFQNFGKIDKEKMNDKINKLKTRGGTNMAEGFIEGSRMIEKYLKSQEKEDLERENRIIFLTDAQPTTGETRSEGLFTLARKASEKAIFTTFIGIGVDFNVELIDIITKTKGANYYSVNSSSEFKRRMDTDFDYVMTPICFDATIKVDGAKILSVYGSPDAESEKETTIANISTVMPSNVNENNEVQGGVLLLKMDKSVGDGLPLNITISFKDKLGKEYQEVINIAFPELQNDQSEFFQDLSIRKAILLVRFVDIVNNFQRNDEGKEKVKKFIDYLEKEIKIIGDEKLNREVELLNDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6V6</accession>
    <name>A0A9Q0L6V6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory-associated protein of mtor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HNYDKAR"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="82"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="976"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1220"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="869"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1360" mass="155495" checksum="8A0D4EB333AFF26A" modified="2023-09-13" version="1">MSQNNFTSNSLNSNEIKNNSNSNSDLNKNENKNENQNQNENNENENSQPKVYLENKIEMKQNNKFLEEMKEVSHESWKIQSRKKTKSAILNLCLNIGVDPPDVEKPDPCSILECWINPLSLNEQKALSAIGDTLEEQYKRWQSKIRYEQLLDPSVDNLKKACIQHQRLSQNERILFHFNGHGVPKPTKNRELWFFNQNYTQYIPVSIYEILTWLGNSAILVLDCAKADLLAPAFLSKENTILNSVNSEEEKDYILLAPCQKKQDLPTNPRFPADLFTSCLTTPIKTSLLWHTHSNIYSKTLLNNIHVEDLDKIPGRLMERHSPLGELNWIFTSITDMIAWSSFSNRLFKKLYREDLLVAAIFRNFLLAERIMKSMNCTPFSIPQLPSTDQHPLWKTWDLAVDICISQLPEFLSDSSYVFKSSTFFRDNVIGFENWLLSGTQAKYGVDLLPILLQLLLSQSYRKHALHLIAKFMDLGSWAVHKALTVGIFPYMLMLLSTHELEMKLILVSIWGKILLFDKSCQADIVKEKSYIHFIDLLASSEISHDHESAAAFVLSLILDHSHEAQIGCLNSNLLPICLSKLGEKSESRKWSCLCLSKLLEGFEEAKKQAVAAGISDKLFKLLKDPNPIIRACVIYGLSNTISENNDQESRNSEEFSISISLLGTANDGSPIVRRELLVFLSKLICLHEEKVQKVAMDIDEELSQFKTESIEDENSDHHSAIFSMWWNTLMQFSSDPYDEIKELADDFINKLRNHWKPIEYIDSEETENSTLKKQKQKQTRKGSLNKNHNSALGLLRNRSDKSLFAEAVDTKKHSKSFAFSNSPTKNKMATHKILKGIQDQTMEMESCPLNKNESDVSNLKPRGSSKNLQKESRSKISQETKETEKEEKMVPLQSTLFDLCVDSYSPPEDFQANNSVSISISMSFPISSQISESNNQHKAWRIREIEKTKRSMIQNVKESSIQKAKIQLNDQRAVIDNQTAKVTSVVFHPYESMLVCSDGEDEIFVWDWVENSGKLLHHFHNGNSGQSRISYLSLMNELTANPYVISGTTNGVVKIWKNCFIQNQNKNENENENENENYNHHEKNENQNENENENQNENQNQEILNQDINKSKEKPSLVTAWAMFPSFENKGNIADSNSVFDWNPNNGIVSGFGANRMIRLWNVETENQLQTLPTNSERGLSCLNHDPKNSNILFGGSYNGKLLVYDIRVKPAMSLVQCLTEHKNQIINFKKQFDSEEVLISGSVQGDVKFWDLRKPYALKTLTPYQGLMTALEIHDYCPLIACGSNIYLVVHFNNHSNNHSVKIFNTNGDLLNIIGYYDSFIVQKLGMVHAVSFHPYQIYLAATADSLISVFIPSYLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L735</accession>
    <name>A0A9Q0L735_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nnp-1 protein putative nuclear protein 1 nop52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L735"/>
    <dbReference type="OMA" id="FAFKIIN"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="500" mass="59426" checksum="373CE40185D86D9D" modified="2023-09-13" version="1">MKMKMKMKNENQNQNQNQNQNQNQNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQKENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENENQNEINEFAFKIINILFIYSFYNTNYNFPKIFQEFISSIYLINSINNNSIIKIISRIINNIIIDITKNTSQTQEKKPTLSTIKISGVSIKKEEFTKNLFSLIQILNMAIYNLPNNNIKIKQSKQNENKKQISNEIIQAYVSNQFFKMTNLKIKKSNEEENEDENEKQNENEKSSINEILEIKIGKGIEIIGKEIIKNLIILLEKFGFFKNGGIQSKNKEETRIIYKIIIFLIFATIQNQIELTEFLLSKLREIINGPLNYKISSIQNSQELISTCFLFLFSFIHNHNQIQIQNHVEIPNEMIEKKLKRNLLLINLQMIMQENYNFIFGLFSNQNKKYNVLSQDTKNSFVFKLSRFQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L798</accession>
    <name>A0A9Q0L798_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="966"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="2284"/>
            <end position="2381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1448"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2383"/>
            <end position="2405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1461"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1484"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1501"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1519"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2385"/>
            <end position="2405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2405" mass="278942" checksum="A242831BDFD5D946" modified="2023-09-13" version="1">MDFNSVFYYQSQLKNCYPINFGGNEKSLSNISQKRFKNKLFEPYSTFPFMDSEIGMIYKKYEEKTSKIEIILASIQILVSKFVYTESPVSLAVSLQNNSFNLHEICVTETNPIPITIENRHEIETLEKMLEKFNDKTKEIQKISHLFSQLVFDYESNYSVSKLDFPFRILVVYDEPEVIEKLSESSVILRHFKKDFQFSRNTEQSEDIQQQKKDLVAFYSNQFPAKQYFDLIFAFVDEEKINPSNKRPFYFSTILYNNLKFEDSFIGNLHFYLSKLLENISNQMKNNTSILVSSLDRIEDYEKQNILRKWNGKGEEIIAKSEKVSQVGIPLIFRKIVKERKESIAIRSDTANISFIALENASNLFAAYLQQNLKMQPGTFVGVAMKHSVNTIIALLAILKIGCGYLPLDNGLSKKLSAKIVKASNTKFVFTDEQSLDKFFEIRIQLKPHLVEVVDLSRQNFDDILQECKEKNLQKSKIKVTGRNYMVMLYSFIRSHKPQFFMVSHSSIILKSLSINPPINMCNITLLHSSLASHQSLIELWGTIINAGRIIISESTNVFSPNFASLAQRHSIKVVFLSSYLFQQIVDNHVNNPYLREKRKDRNAKSLKDSDDAHSENNFPFSILELLVLYGEPIEYNLMDKFFKLNLLPEKIVFTFALTEVSSICTNLVIWDRKTLFQTKQKIAHSQSDESMQAEKENGPTDEIVQQTNLVNNANIRYYINEYKTSTNYFPLGTPSNDCRIYVLNKKLELAPIGSVGSIFISSRTLSAPVPIVEKKKELQTQSPKQVQPQRQLPKSFVPNPFQDVDSGKFLINTEVKGSIVSSGNLEFMEYSDPREIKLTYSNGDLVSISVIESVLKKNYKISQVSVVARDLHLYNRKRLIAYVVPNTKKPITVDELRRSVQEHLPSQNVPDIFVVVDETDSSKTDSNGVLDRMKIIRHYEMMNSEKKRKIRDRFSRTKSEEITKYPRNPTEEFLCQVFASVLDYEQVGIDDNFFSLGGNEIAANRIALKCIDAGFQVSVEKIIKFPVICDLSEYIIETMNFFQTNLALSANQKWFSQQKFGNVNQSSRAIFVRFNSSTNIETLRKAYFMILKQHEIFSIKFPNLKPAISPISQENKKKIKQMFTITRFDHKSTSPSEIVKQCLQIQQTLDIAKGPLVKFVIFVDQSLENSDDAVKDKNDAQFILSSDNTDTLDDIQDSDEDTKPQNHMFSMFLFHNLIIDTNSIRTFLENLHQNYTNISTMKKKIYRNLQPSFSSYYEWINEETNLEISTNAYEFWKKTAQKKPNYVKPLPKDFSTPIDNLYEYSSNIKVSFDYEKSHLLYVKTAQKNQYEFTDILMTAVALALHDWTTSIYNFIHLIEFPKNVPEKFRKLVCPKENRIPVLIGFTQPNVTADLVKSLALVKQQLTEFRENIHQYKRLMYYNTLNLPNVAETFEDLIQYDTVVNPKEKQTPLRRQSSVKDQIKRTESKSKDTEILKSPLGFEVPDHDIHPIELESDSLSDDGKEGRERSQSNRHGNADDDTISQEISSDEDDSRLKMPDNYQAELQTLEESEIGFTFLGDLEFKSFPLGSVSIDKVTDLKRIRKLNNEKSAMPYSVEIISYIQDECIYLKIVYNKKMYKPDTIKNFSRKVMKILLKLSKKLGETIPTLPPQENTNENKENVPKGRLTVDFPLAKNLTNASIQELFDENNSIENIVTPLQLHQEMLRFFLRKDQIVKRHLCQQLMLPFFTTKIDTQLFQKACSTFINNCTFLKSYFIRNPTKQSNILQVVQNQVEIPFKFSSFAKESEPMKELSISKLLSAEQQKQFKFSHPPLFSITLTKVAAHDSINEYLLTFSFEPFMLDSRSIPLLIRGIFYQYLSYYYSFNAFDPNPENENSQPQIPKDAPKNLDSSLKMHSKSSFLNFLKAEQAIPITTVKKFFQSMLHGIDFSFPMIQSRSSEQENSIEKPQENEQTQKDDFIILDQKQDSQKLGVCTQILDRILNTPSTLLEKKNTTDVDVNGQILFDNVKFKELNHVITSLEYHTINETLRSNSINLNAFLHFAWAFTLYSVTHKSTLYFGTEATGRIPEAGQGNELTVGMFSKILPFKIVLQKDIKLFSLLQHIQLNLVRINEYHKATTTKIRRWMELGRKYNLFSGGVIIYDSMHSPEEICRLKDLGNDSYDLQLDFSENFPKAKIAFSNIKIRRAFQFPLSLIIDPSCDELMVRIVYDEDKFPKSLVAKLFNNYIKIITTIGLKHKNFFNEINYFIEELIVKDINKDLYANEKPKKRRVKNKANLAQFNPDHVFKMGFLTQQRIAPSKSKWKKRWFVLKNDNRLYYFKTRNSPHLCGVIQLTNASIEPLSDSKKKNCFQIKDDQQTHLISAESSDLMRDWIKEIKNILTRQDNDEDDEDYDDDDYQEFEEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7U3</accession>
    <name>A0A9Q0L7U3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5067986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250315at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="46"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="37"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="40"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
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        </location>
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        <location>
            <begin position="1129"/>
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        <location>
            <begin position="1231"/>
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    </feature>
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        <location>
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        <location>
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            <begin position="1400"/>
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        <location>
            <begin position="1709"/>
            <end position="1777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1803" mass="205502" checksum="7E6F7DB32929AE2B" modified="2023-09-13" version="1">MNINIQQIIEKNDIESIKKIQNISENIIKPILHFAFKKEVSFEMIKLLIERGININAKNKNNETPLHLACKRNSIEEIEYLISKGADINAKTYENETVLHFACKRNSIKVIEYLISKGADINAKTYENETVLHFACKRNSLKVIEYLISKGININAKTFEKETVLHFACKRNSLEVIEYLISKGIDVNQKTEENKTALHFACKRNSLEVIEYLISKGININQKTFENETALHIACNKNSIEVVRYLISKGADIHAKTNENETPLHFASHKNSLEIVKYLVEKGIDINAKTNGNETPLHFASHMNSLEVIQYLISKGADINFKTSMNTTVLHFACQKKKLDVIQFLISKGIGVNLETNEGETALHFACRKNTVDVIEYLISKGANINAKTNDNETILHFACKKNTLEVIKYLISKGIDIHTKTKTNETILHLACKNNDIDVIKYLIEIGIDINAKTSRKRTALHFITQRNVPLEVIQFFIDKDADIYAKTNWDETVLHLASWDNSLEIIQFFVEKGVDINTKTSNENKTVLHLACQQNSIKVIQYLIEKGADINVKSSENETPLHLACWGNSLDVIQYLISKGADIHAKTDENETVLHSACQNNSLDVIQYLVEKGVDINAKTKSDENVLHFICQKTLQIETIQYFVEKGVDINAKTKDDQTVLHLACHKASFEIVKYLVEKGARINEKGNENETVLHSACFNNSLEIIQYLVEKGVDINSKTIGNQTPLHFACKSDSFEIIQYLVEKGADIHAKTKLDETVLHYACWSGSFEVIKYLIEKGIDVNSKTVENISILFFACQNNASFETVKYLIEKGANVKEKTNENQTILHTACENSTSPEIIQYLIEKGVDIHAKTNENKTTLHFACEYNASIPVIEMLIEKGADVNAKTTENETPLHILCQDNSSLEIIQYLVENGANINTKTRYNETVLHTLCQHNSSLEVIKYFVEKEIDINARTEQNKTALHLACRSTSSIEVIKYLIENNIDINATTNRNETALFFAIHNDLAFEIIDYLIEKGININSKTNQNETILHFACRNNPSLEVIEYLISKGVDIHTKTDRNETVLHYACQQSSLEIIKYLVEMGVEINTKSDYNETALHHACQYSPKLEIIKYLVDKGADVHAKTDNNQTVLHLVCENNSSFEIIKYLVEKGVDVHAKSNSNETALNFALWNKSPLEIVKYLIDNGADINTQTDQNETLLHFACQSNSSLEIIKYFIEKGLDVNAITIDNETPLHYACRNNSALEIMKYLIEKGANINARTYDNATVLHTVCQNYLSFEFIKFFIESGVDINAKTNENETALHFACQNSPFRDIKYMIEKGADINVKTNQDQTLLHYACWGESSYEVIKYLVEKGADIHQKTNDNETLLHIICHYSPSHAIIEYLLEQGIDINAKTEEDKTALHFACQNSNTNSNEIIKFLIEKGADVNAKTVYNETALHFACQSDQSLETIEYLIEKGADVHVKTNRNETVLHSACWSYSSVEVIKYLVSKGIDINAQAEDEQTALYQACSLNSSQIIDYLIEKGADINICNSYKRSPLSLSIQNRNQNAIKNLTITSNDSFKFNVHKLFLLTRFDNDEPILQKFINNCYQKPKKEVEIALNLLYTGFVDFDEINQLFVARGNDDNDSNSFSDDDDLSDDYDYYAQKNTKPSKNSLKVLTSNEEKESLIQEFFKEIGFDSKWIETKKGRKSLLKDFHNLYQNEKTKDFSIICEEEKEVKVHKLILILRSELFKGMFQLNVQDTSNQVHDYSGKSFETIQQLIYFFYHDEFEESKINHKIIEELKDAKDYYQLNPNSIIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7U9</accession>
    <name>A0A9Q0L7U9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mfs general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_13054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7U9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5067384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="486" mass="55445" checksum="2487FD57482A392F" modified="2023-09-13" version="1">MWGQVFVIAFSVVSDALNIIQSIPYIPFLIESFHITDSKKQVGYLAGLLMSISHICQIFSSITTFLFGFTFNIWWVFLTKGLSGLLYENIGIANTILNEICSSGNQALCMSVVGFSFGIGSVGGPILGGYTVHLDAKKGSFLDEYPYFLPNGICAGISIIGAISNILFLSETLKKKRPLFSCGLMSDKNFEIPKENKILSNLVLDPNFLICSPNNLNDEIISMDEFEEIEFENFTSVSDTDFLNKNQHKENYYENQNENDWAEILLVTHFPKSKMNSISTSITSEISEVENENATTFNKKDEDEDEDELDEEMDELNYQIFERNFKDDEKQSFGTFLKSHKYIFLLCLLYGLISFIFIFFDTIVPLLLFQEEKDGGLDLKHMKLQQDHQFLVLLFIFQILLYPKISRYISPLNAYRIGVGANALVFVAFPFINSIHVRFGWQAGWAFYLTAMVLRSLFESLTYSSTFILINNSAKSFRFIFITQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L888</accession>
    <name>A0A9Q0L888_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L888"/>
    <dbReference type="OrthoDB" id="5572587at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04519">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF150">
        <property type="entry name" value="RAS-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="34"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="598"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="955"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="866"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1063" mass="124685" checksum="1608E32C8D56147F" modified="2023-09-13" version="1">MTNRLEYRKLLLKVAFHKDIFRLKKKQNEKIETVHPLELLKRWINFQFKINSKTLKISNIKSDLKDCLILSQLLFILSQNENFLSISNLQNYYERALKILDFLKETDYTGFLFNPNNLIKGDEPEIIQFLVNIFLWKPNLKEIETEKEDQENNKNQNLEVKTKQKDFDYDLVLSTSSTSTDFDFDSDFDSQEDTGFSQDDFTNPIQQEKFEMISNNQLFDFKKKLKTKTNENENENQIKNENEIENENQIKNENENENEKISIKDEFIFHFLDLESFSFLQFQEMHKIEIIIQTFSKIFEEIDGNSNNTDSGKLAFLQRLKMFHLRNNYGLISNLNRNLFFQIINDILKSDFNYFNPLIQQQINQELLAQDNYGCDPLYISSQIKGILQENCKLEKEADLSLSLLFDLFTFTMVVKQQITTRLTSELIADSFINPDQMKLIRNIIYKSLDTAIFGLIDFINLTKILKHYFSFFTEKDFLSKSQLVVSQTIKIALGNTIRAIVNRILDDKSKELVEKSIAKINQEFKSFGNEKNTNSQVIEKGMEILGGYLFVEDIIFLQAALDEENCLSFQQQLVDNFYYLFLQLDIFIPMIKFLVSRQIITQKNSDMLFRANDVLAKILTKYSSHFAKDYLHETFHDIVDEIFDRIIETSDKIPFGFRIITSHIRNEMQIMGLEEFEKAIGSLIFLRFLCPAILLPISFGIIDYSIDPESERGLLLLSSTIQALGTGKQFGSNRVYLQPLNQEIQAKSSQTTELLKRISNFEGEICYPTHLTMEKILKNTPLSFLAQLYQSQLKNVKQSKANGYDLFLSVRRFIKEKKLLQNPKIEIYQTEKMIRETTQLDEKTGFLIQEIEFIEKLLSEISTKHTEKKSTIGTNESQLSHGLNDKNKSEDLSETSGETEYSDSLTIPEDVYKEKEEVYEDTLNQNEAARKFESGKTFANRNLFFLWKDNWKTPTLMEGFGLMRRKSKKKWSKVYFVLKLEFLAIYENLSVNCYKDLIDIIHITGFLKIVKLKKTSKFNKKKVKQISIMTEVPTKQEIIISSENDFNIEKWFELLIQIQNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8B4</accession>
    <name>A0A9Q0L8B4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000123">
        <property type="protein sequence ID" value="KAJ5067936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8B4"/>
    <dbReference type="OMA" id="ASWNDER"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="67"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="201" mass="23395" checksum="2F7FDF6587E6BFA5" modified="2023-09-13" version="1">MQFESFNQILPNLFLGPRFVAEKNIENLIKIGITHILNVTKEGETPYKSQFTYKTIKIEDDLGVQISDYFDSSFEFIDSSIKNNGKVYVHCDAGISRSPTIIIYYLMKSQKKTLKEAFDFVKERRTAIRPNISFFKQLLKSEVDLFGFEKPSISEEIYAFGIFKDIFPSLSYNDFCSFYEENGRDILKTEEDILSSLIRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8V6</accession>
    <name>A0A9Q0L8V6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5067990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="MCEHSEL"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="466"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="565"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="598"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="730"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="764"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="800"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="833"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="867"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="901"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="934"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1111"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1368"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1462" mass="168294" checksum="4AF0DC867AF88C0F" modified="2023-09-13" version="1">MENNFSNQIIQNLIQKEQNINLFTNNLQQNSLHFAIINNFEIEIINLLIQKQININKIDKLKNKPIHYAITELKGKKREEIVSLLISKGADLNSLNSQLKSPLHLICEFKNTKEIVNKLLNAGANPNLTGFHGKTPLHYASTSSSQDVIELLISKEAEIKLKCKQNKTSLHYACQYNSLEIVKYLVEKGIDINAKSKKNETVLHFACLNNSLEIIEYLIEKGVDINSKTNNNETVLHFACENNSLKIVRYLVEKGIDINSKTNKNETVLHYACLNNSLEIVKYLVEKGIDINSKTKNNETALHYACLNNSLEIVKYLVEKGIGINSKTKKNETVLHYACLSNSLEIVKYLVEKGIDINFKTNKNETVLHYACENNSLEIVRYLIEKGIDINSKTNNNETALHLAFKHENNSLEIVKYLIEKGIDINSKTNNNETALHLAFKHKINSFEVIKCLIEKQIDIDLKSTINEKILYLACEKNSLEIIKYLIEKGVGINSKVDQNQTILHFASQNNLIGIVKYVVEKGADINFKTNKNETALHFASQNNSLEVITYLVENGANINAKTNENKTVLHFACENNPLWIIEYLIQKGANINDKTNLEKTSLHFACHKNKLEVVKYLIEKGIDINAKTSHYETALNFACENNSFEIIRYLVEKGIQLQKNSFYRETVFHIALRKNSIEMIKYFDEKGINLFQIELPKKTLLHFACEQKCSLEIIKYLLSRGLYINAINGNRTPLYYACKHNAPFEVIKYLVEKGANINRILTRHETPLSVAFQNNSFEIIKFLIESGADIHIRNKHGNQKEVPFFYAYKNNSKDLIKYLIEKGANINGIGYQNETILHTACRDKSLEMIKFLVENGADVDARNKYHQETPLHCVCSKKETFDIIEYLISKGANVNCKTHSGQTPLHLVCKQKAFGTIKYLIEKGANINAKNDNNEIPLHYACRTNSLEIIKLLVENESNTQIKSLIEDQDALHTVCKNSNSLEIIKYFVEKGIDINSKTFYNETALHYVCMHQQHVQLDVIRYLVENGIDVNAETKLARQTALNIFCDKKANSIEIVEYLVSKGIDVNSRNISQETPLHLACKHNQQDSLEVIRYLISNGADINAKTKINEETPLHYACKQKLNSDEIVELLAKNGAEVNVFDKSNISPFSLSLNNQYPNGITSVIAILFIYGFDIFKTRLSQIPSQIIELFLKINSINEDMNNLLQLNQFSDLTIKSNDSFQFSVHKLILLKRFDNNESILQKFINNCYQKPKKEVEIALNFLYTGFADFGVYYEKLHKVIQLNNYIEMSEKLFDSKTISWREMDDIRAKVNNAMYIELKEIQNKEKINLKFFKEIGIDSKWIELKKGRRNLIKDLSKLYEENETKDFTIICENEKEIKVHKLILILRSELFKGMFQLNVQDTSNQVHDYSGKSFETIQQFIYFLYHDEFEFNNEINEELKDAKDYYQLNQNSIIDLFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB07</accession>
    <name>A0A9Q0LB07_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB07"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="235"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="340" mass="40324" checksum="25BE3F2266C47FC6" modified="2023-09-13" version="1">MLIEDENENENPKRKLYSCGDYQYNGLGKNEDTYEFTEIKSSLFENDDDILDISCGNVHTLILTSNSILIGFGNNWFDQLATGDTVEQSIPIQIELPKLRFNENISNYHISCGDDKSFLYYSPLPFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEMIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBT7</accession>
    <name>A0A9Q0LBT7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBT7"/>
    <dbReference type="OrthoDB" id="10667156at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="736" mass="87052" checksum="402AEFAC9B8B1530" modified="2023-09-13" version="1">MDIFQIKKLQNIQWLNQDETLSAVDSCEYFFVVGTSKGSIILLNQEGNLIEMVTRIHESAIKVVKIHKFKIISGATDGTIKIWDWFKNKTKEFGSKLDNNQSITSLAIPNDFMEEKHANYLYFGTSSGALVKRSGPSFFRKFNDNLIIQLGDRMPQSIEEFWFGFSSTKTQATFSIRSLELVNDLLFFSYGNSIMVYDLKRKKFVVQFEMKNLQNENENENENQNQNENENENIHKNLQKILPQFKIYHHWFIALINNIIYFCNINPDQEISIEKKYFSPIPVLSFGILNDVIVLSLLNNQNRGENKKRYIDFATLDINNLEIKATDYTSIPCKNEDSSIAFINDSITSLKAPENTFLIKKSEEKGNRFSWILCFETNLLLIRPITASEKILYYIQSAKFTKAMDLCTRFNRRKELIEVANEYACFLWKTETQQQKAMAVWAEYCLPQASREYWNIFAERLTKNNRLHLLEPYLPFNNKQLLQEKYYNIILEYYLENSLLKTFLKCVDHWPILYSIEEITNLLCQKIIELRTKNGNKISNQNHLIQQDEDEKSIRHLFNACFKLCIYQAMHIDALKCLIELEDPKVMEYFEENSLWKYFYLNINNIIQFEQLSFEIFSFQYKRTQLIQLLKKNRGNFHNLLSSNPNVMELVEIERSALLLKLIEIDKEKIFSFISIYFSEKEQIESIKKLLKNHSDLQKEFLIHFENYKKNNNNNSNNYKNNKNDIILQENETKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD13</accession>
    <name>A0A9Q0LD13_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5'-nucleotidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD13"/>
    <dbReference type="OMA" id="LWARGNR"/>
    <dbReference type="OrthoDB" id="6503940at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF12">
        <property type="entry name" value="FI20020P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="390" mass="45916" checksum="0BF1CCB660BD3360" modified="2023-09-13" version="1">MNKVNFWKQFQETRFIGFDLDNTLIQYKIQNLAKLLFECIQNYLVKEPNLSNLKECVFNPKICAKGNIIDFEKGNILKLDEENKITIAFHGSKRLSNQDIMKQYDNGFLKSFTGKRDEKFLPLATEFGIGLGSFVASLIDLFDQEIKKGNDLKYSSLANHLYSAMDRNFVEWENGQYFRTIEANPTKYVIPSPKTRLLLEKLIENKKELFVVTNSIPEYTRLLLDVCIGKDWRKFFKIIVYSSSKPRFFNLDNPFEICLPENEDKKSIVEFLHGNFKQLENELKKLTNPKNENENEKFCYFGDHLISDIQACKLNSNWITTGIISELNKINSNEHEIWGNFFYCKESLEESKTEDKKSFWKLISDKYCDYVTSSLEDFYNEYQEFLNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD65</accession>
    <name>A0A9Q0LD65_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L27A-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD65"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="17179" checksum="7D59632BCFBFE573" modified="2023-09-13" version="1">MPSRFSKTRKKRGHVVMGYGRVGKHRKHPAGRGKAGGLNHHRIAFDKYHPGYFGKIGMRRYHMLSQRYYCPIINLDKIWTLVPDEVRQKYKDAKETDEVPIIDAYKHGFFKVLGKGKLPKQPMIVRAKFFSLRAEKKIKEVGGVCIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD79</accession>
    <name>A0A9Q0LD79_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dymeclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dymeclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD79"/>
    <dbReference type="OrthoDB" id="10253409at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895:SF9">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="859" mass="100724" checksum="CE89B03BA6D4AFF6" modified="2023-09-13" version="1">MSKLIELFQDSTSLAKLTGKTTINENDNQFWKQLFEELTGPLSKLDIREIDYVIRTKFTNFPQNNESTHNFQKLLIKGIEKLQTIHKDFANEKKNDEKLTLNIVNLLFLMRVFSQYIIETNLAPFSDPEINDLDLTNDLDPRSMSKKQRRQWEKNQKKKNKKNPKLSKLSKESIINENIEKDENNMLSEQTEITELYNPTKLREHFSYPSMDLPKLLMETLTNYIIDQNDATEFSKYVILVEVIALMISLLSTSVFDVNIFENKNEVVTSELSDHFSDVVWIEVEEPSEENDSFDFSHFVYYMDNEKIRTLVTVLLGHISIQLQTPNPDESQWDNSRRGSFIFSPVFAIKKFFKHSNSDPTPLSTHALSLLLALLQTRTQDEFGFENDLLYSKDNLESNQFVSVISKLKNLNLDDDTEESIAHQIPFKMLLCNTLCSESVNEQSLLLAYHLLSKNKDFLKFTLESQDLSKTLLYFLEEIYQYTHGLEEYQQEKGSIIHLFLVILLILSENDDFGTFVFSQFVAVVNWYKETQLKNISIGSLCVLLLLELTQLHFPRLTSTELINSSLAIVHNLSSSFANLPVSTSEKLVEIVWFVSNKVKELSNYQGDDEETEIKQEFKSKKEEKKRRNELKKLEKKKKKQEKEKLKRLRNSSKKGIEPENLAEDFDITEIYFSDWTDIEELSTPPSVEPRPKRLVRPQKDNIFIKHNLQFPPELKFYTDVLLNLCEIINTAFTLKITQNIHLLVAILLNRKMLFSFEHHPRLWVYISNLHKLARFLNFEPPESAEILNHGIEEMKEIIKKKIPRFVFEEKGFQVLPHTKFKFFETNTKESFFFIETWNSIQKYSSLYLNPNKILILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDC6</accession>
    <name>A0A9Q0LDC6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDC6"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="427"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="526" mass="61768" checksum="A4A029E0927C25AC" modified="2023-09-13" version="1">MVLIGKDFSIEIIEYLIKQVLIEMDIKVQGIVLNSNQNNNENNKNETNIINTLTDSQNRNILHLLFLNKTYQNHFFQISKYLLQLSPSFIIQQDNSGSSPFHYLCRYSTDVKLIEFLIKKGANPSQTNKKLDTPLHNLCSSKNNTFFAIKYLLKNHKIQIDAKNYKNQTPLHLLCQNNQNEKILKLLIKHGANTQNIDSFKNTPLHYCCLRKPSLDFIKIIIQTKPEISPQNSEKKSPLYYLLLSKSTGESADFLLENGAIEELYNFSDGFIIKIFRTFNSCLIDLFVNWGFDIEPFMKRKNSQFIQKYRQIFSICEDFIKLFRRQELTDYEIKCIDGTISVHKIILLSRIKEIGIENFTFHLSKLEKKEANEILMFVYSGLIKKNYVKLVDFFAKMGIKKELFWKKIGRKGLLFDFKRLFEDEESKDFEIILENSQIKAHKTILIARSELFRGMFNSVQDDSNQVHDYSGFSSDTIEVLIKFIYLDEIEESLDDLVLNELFDSCEYFQLNRYSKIHGELFEQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDH5</accession>
    <name>A0A9Q0LDH5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="456"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="499"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="1275"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="57"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1387" mass="159926" checksum="D4B0AA433A0EBDA7" modified="2023-09-13" version="1">MNDSLKEIDLKENQNQNQKTSRTSLFGNPNLNQNSILFQNRNHNSNTSRTYLFGNQNQKKNQNQNEMQKQIQLLLQNQNEMQNQIQLLLQNQNKMQNQIQLLLQNQNGNQIENENENENENENENENGNENQIENENENQISNLNENSIEETITYMKQYPNDQQIQENGCRVLLNIVVNNDKNRIEISNLKGIEPVIKAMNNFPNNENIQSFGCRVLLNIAVNNDKNQNEIRELNGIGLIIKAMNKFPNNENIQIYGCLALGNIVNNNNKNQNEIRDLKGIEPVIKAMNKFPKNEDIQKYGCRILWNIVDNNNNKNQNEIRDSKVIEPIIKAMDNFPNNEDIQKHGCLALGNIVNNNNNNQDIIRDLNGIEPIIKAMNNFPNNEDIQIFGCAALLNIAANNDENQIEIRDLNGIEPIIKAMNNFPKNEDIQIFGCAALLSIAVNNDENQIEIRDLNGIEPVIKAMNNFPNNEDIQSFGCRVLLNIATNKENRIEIRDLNGIEPVIKAMNNFPNNENIQEYGCATLLNIAANKENQNEIRELNGIEPIIKAMHNFPNNENIQIYGCLALGNIVNNNNENQNEIRDSKGIEPIIKAMNKFPNNENIQKYGCSTLGNIVNNNNENQNEIRDLKGIEPIIKAMDNFPNNENIQKYGCSTLGNIVDNNNENQNEIRDLKGIEPIIKAMDNFPNNENIQKYGCRVLGNIVNNNNENQNEIRDLKVIEAITKAMDNFPNSNRIQAFGLRAILNISLQDQNQIKLIQAQGFGALKKIKNFDLKFINFPNLSSQIDKYIKRIQESRKEKLREKPNDIWEFDMKVFPSNNIEPIQNIQMKSIKVKLHDQFQSEYKSQIKQISSSNRFKNFLFQNGELFRQINTKFFNSGNDSDPNPQKIQIEENIQKVSVGEQNEAILTIEGNVFAKGYDINPKNPNEFINISSSIEDKNDRVIKDIVSGEHSIYLLTSNQNVYGIGLNQYCQLGLDSKTLEKTEKPILMMENVSKIFSGNYSNHVFLLNSNQELFGCGSNFYNQLGLGNSMESTLKKLTKIQNIPKGKIIDIQCGLFHSVMLIENENENGKTKIYYCEDYQSKFTELKNPLIDNSNISEISVGRYHTLILTSNGKLIGFRENEKHEIQKPKDQPSFTLYQIKLPKLLFDISNYHIYCGNETSFLYSAFFSSLEGDLIELFRRKEFYDISFKTKNGEMIEAHKLIITFRIGSQIEEFKELISQKTLEEANQIFEFVYGNINIESQKLKEEIQFKFNLYPSISEEMEEMHNDETEKDYTITTNGKEIKFHKLILIARSGLFRTMFSTITGYESNQVKYPNQISDKAFEIMKYWMYTNQIQEGISITKKEIKELEKAIDYFQLNQSNPNLLDLVNELYEEFFIPEIIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDL3</accession>
    <name>A0A9Q0LDL3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDL3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="219" mass="25260" checksum="708D33E6F6DC1F04" modified="2023-09-13" version="1">MDQKKAIQNKVFFEPQYHRVGSWNLGSSPQGFSFETGFRKQREELDNLRQILQNKMKSKLSKTKNSNSKLNSNPNINSNSNSNSKSNSNSKSNSNSKSTENSNENLNINSNSNLNSEIPIEKQILWSHLDGVGDDFLLRNSTLAIRDKKSIVREILFQKEERTVLFRILFLEHRSLIIKQLCHQLSKKRTYYLTADLISSNQGNTKISELMRQKTPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDT4</accession>
    <name>A0A9Q0LDT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDT4"/>
    <dbReference type="OMA" id="HRMADID"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001204">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="211" mass="23573" checksum="8EB5380466CFBEB7" modified="2023-09-13" version="1">MGEAEVDLKIILLGASGVGKTTFVNKVIYNKFEEKPETTLGASYLEKKYLSSLGSEYNFGIWDTAGQERFDSISQFYCRNAGCALIVYDITKKETFAKLDRFVDKLQHAKPDVFTIIIGTKLDMVEETKTMREVKPEEGQARAKTLNAEFFEISSKTGYNIDKVWEAIGKGYEKSLIRKGRQPANSNSNTNSNTTVKVKDISTKKGKSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDW9</accession>
    <name>A0A9Q0LDW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDW9"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="678"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="838" mass="99915" checksum="D52C75F55C30787E" modified="2023-09-13" version="1">MSFQNLNENLKQTSSANLTLQTLQSKINSLKEQKNDFLYKISLLKQQEINDFQINFKQELFDQITNLSSEIKLLKEKFSNYCFSTSQTSSNNNNNNNDNQFKKIKKKIQNLQLSESNHLAIKSQVLKYLEIISIQLKTFEKEIIYSQNKESKKLQRNLLQIENLKSQNSEMNQDLNSCNTIAETVLSVKKLENKISQERKRRIRKKRNKLNKYSHQKQELIRSRIFQLSQQYPQLTNLVFNKKTWLNLRFEEDQNDLENLNQINGIEINDEFEVSFINENDLENQNENNLENNLENDLENDLENDLENDLENDLENDLENDLENQNENDLENDLENQNENNLENDLENNLENDLENNLENDLENDLENNLENQNEINLENDLENGNHLENNLENDLENDLENQNENENDLENQNENEINLENQNENDLENDLENDLENDLENENQNENENQYQNQNDLENDLENDLENDLENDLENQNEINLENQNENNLENNLENDLENDLENENENENENKNQNENDLENENENQKENQNQNQNQNQNQNQNQNQNQIQIQNQNHLKNQNENQNQNQNQNQNQNHLKNQNHLENFDLLIDLLSDNPSNQKSNFQYKYGAFFLSNSEKQFLPFNSTSNHKNSHSLPVNIQYSQNKNQNFIRKSEIFQNKNTKIIQLLSTLYSEHQFMKREKNKLESILRNLQIFSQNKKEKEKEKENLQEIGEIIEEILKEKKKQFHFICKLSERKDDFGLTMKKKNEKIKMDLIFPKTKETEDLRRLIRRGIYCHPNKNKTAYAFLSNFYPARHTVFGAEYLTTEHSFQAQKFLWEKSTEEDKIQAEKIRIAKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF43</accession>
    <name>A0A9Q0LF43_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">M0811_10215</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 19"/>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF43"/>
    <dbReference type="OMA" id="DKDGWAS"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="24">
        <location>
            <begin position="78"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="444"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="511"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAJ5071583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="550" mass="65121" checksum="68076ECB36FE3921" modified="2023-09-13" version="1">MQDFLIEEKFKRQIQSHQSKKNQNREQPIQKLDKYFHKINLATKISLEDDLSSFSTSVTNSAQKVQKKMQNNRKRQKDVSDRHTIEQVIDGRIRMIIFKLLNQAVIDEINGCVSTGKEANVYYANSEKNGEIAVKIYKTSILIFKDRDRYVSGEFRFRSGYCRHNPRKMVRVWAEKEMRNLQRLNNAGIPSPKPIILKGHVLLMSFIGKNSIPAPRLKDALLTPQKVKKCYYQCITLMRKMFWDCKLVHADLSEYNILYYKSQCYIIDVSQSVEHDHPNALVFLRKDCTNITNFFSKKGVLTMSIIELFEYITDVTITQENEEDYLRLIESRITEKNHHLTHEQQVEQEVFKSAYIPQKLDDVINFRRDKENVLKGNADIYYQQILGMKKDLTEPNLFPEILSQENINQNLNENTNENTNENINENINQNTNENINENENINQNTNENINQNQNQNQNQNINENQNTNQNENENENENENENLTKLQINDPQFSRKKLKGDKEEIREIKKEHKKKIKKEKQEKRKIKIPKSIKKRRQRVVQRKRRGKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGD1</accession>
    <name>A0A9Q0LGD1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGD1"/>
    <dbReference type="OMA" id="WMANILT"/>
    <dbReference type="OrthoDB" id="17956at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="593"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="853" mass="99356" checksum="E9B5231552896D16" modified="2023-09-13" version="1">MKRFLHTPFKHKGKTAIKNTFSFAIISVYQLAIKNCTAWIKWKRGVHSGFTRKAFLSANGYSKWQEEFEIPCTLFQDKKTQQLEKKILHISLKIDKETKKGENTVGKLHIDISKVDPSSPPIIKKYKLLIKNQSKHKNQPIILLCLRLTKGSPKTQLTKLLLDPNIQHLISSIEKEIKESQTGPIVEEDYSEFTMQSSIATVTEDLSDDLNDEKEIKKHSSIDPIEEKYSNFKIPQNQKITRFGISNLPKNGENIQRKDIDAQHHNIFKAEEENKNQNQNQNLDIDINKKQVTIQDTKNNIKENEKNNIDLLDDDFDDDFDNDFDNDFDKEKEKEKEKEKENHFSHESKEDFETFSENDFSVGSQDDTEDKKQPVISIHEENQLNIEEDEKDGNFGFSLSDFARKEPSNTNNNNNNNTMMQKNMENSNPNIGFEENQKSKNIQNENEQIIPTNSTPFMDEIFGKNKKENEEMDPMYSLSVEEVLEKIQSNEQKIESQNALVTILSKNLKELKMVNHEKWLIERVVYFSETKYFKSLPITACILFKFFMNSNLLLGENPQLFPTFLESMKLLIQIHYEKQEYLIWILSNLVFLNSLFINTIPNPKDFLKYTKEIQSLIMKAFIFLVENIVNDIRPILKPQFLENSTLFDFHKDNSTKKISSWMANILTLANENYLPQQLVDILLSQILIFINKYLFYQILNYKHYCTLKNCFQIKFAISELEAWLSLNSLSQLNVNVIPIKEATDCITMNKTILSNVSIINDICPSLTSEQVHNLLSNFSPDELDPQPIDKTRLNSLLLTQNKNPQIVTNETQEGFSIIEDLQIDYKLIKIKDWNHIPIPLTIKNHPSFSSIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGR1</accession>
    <name>A0A9Q0LGR1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGR1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="37705" checksum="BED0F3B7BD5DE24E" modified="2023-09-13" version="1">MEQNSENEQQFSIAKSILEIVNYDDDLEIKKIIEETKQKEIERNKYRSFIYSLNNKFDELLQIKSQKIEENENFCDIFYPIIEEKLKKMEEFPIKISSQNQEIENQNRKKNLLLELENKMENEFAEQEKQKENLISEILIIKNNIIEKEILLNQKEKELEELETNIKEFENESIISEINQVETETRRFLRLKEQSDSFQNLNSDLIKKIQKLNQEEIDLRHKKNQIIKIEKKIKEFLQQRGKLEIENDLLDLKIAEMRIQQNEFEKEKENELENQNQIEIEIENGIENGIENEIENEIENQNKNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGW0</accession>
    <name>A0A9Q0LGW0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-secretase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGW0"/>
    <dbReference type="OrthoDB" id="9997853at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="1">
        <location>
            <begin position="639"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="835" mass="98066" checksum="45B54E98FB3D314A" modified="2023-09-13" version="1">MIKFNLISQLSQFQSQNIQTKVSPNLSNKLLINLNLNSNSNSILNNDIDMNEFHNPENIPQKDIFIGQNNNKILIAKQKTIDNKIKTLIDIFDIEKNVRENLYIHPTSIHCVGASINNNFKTLIFTSRIQRLETTEGHFVAQENNYYQTYLIDLRNPENIFIILPPTQEYQAVFFENEKQIIVILDGKFIRRYNISDQKIILKKNIANSVYWYQFDPISQVLYFITKISASSQETCLWFYSFKQHNKKYFAIPFVVSYLESLRKIYDHQSFSSNLVSPNSNLRISLVKIDPIPSEKQYFQQEICLCQHLTIELMNQNLKERRIRIISLYRKEEIIVSIPLKNLSSKFIMKSNTFITSLFGYLIILIPNIYLSFIDFGRSHLTMESMSFFLNDFVPHFSLVEDNLEESITLYLLKTSLQTEYFGFDIGNFELFSFEFDLSKFPLLFSLLPSDSVVKFAIHAITSHFESDNLVEEIIENICSMNISAFTSAFFQELVVGLTYGEMKKIEMKKIGKYKKVLLSTIPKSSIPGFRLYGNELVPKSYIPRMTKGKIEYSNFSLNLMEETGSFFFFQVINSGKDVKNAENDNISGVLTVKEKEDLLAKHILNHLPKNRIVNSFVEMYSKEEENSTKRVFNILKKLLIPSTVFQNENFLFTENEDEKVKLKQAFKVMKNFYSFLEEMSIPYPHFFQDLFCYLGYTSLSKNLFFRYIDNRVIIITFDFIEVLMKNNKEDPQYILYLASYLEHEKEFISVSEYFPECWKNLIEFYSSKFSSKLKSSVFSKQTSNVHRFQKSQQNQFLPFDFIVQKLNENITDDAKHVKFFCDHAVDFYAQNLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHB8</accession>
    <name>A0A9Q0LHB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHB8"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="70319" checksum="0A55B0E368D36B07" modified="2023-09-13" version="1">MSLKSENEISEKKSNKFSTTKKLTKTEDLIENLRFSLQKSRLGQDLIIEANNQKLYVYSSILSTRSPALIRNIPRGHLQLEYNYEVVKTALEYIYTSKCNIPVVDPNQVEKTPFDLTCDLLSFAKEYALHQLEFYCKKFLLSEIERVHIHNETMTQYKTQSFSTIITSPQNILQDENSGIKENDSNPQLIIIKNAIVCQLESVNTLGEPVLLEKVFSIIDKQMEDIIQHRDYLNISDLNLKMILYRDTLNISSELQILQMVIDYAIQTMENENQNQNQNQNRIQNQNSKKGMITIIDQRTHTLLKTDFIKFVRFGALNLDEFSEVIHLDLLTPDEIIDISDFIENINDGNYEENQKIIEKYTKEKEVHWFKSKRVYSNSNTIIPFENEEISKRIHPKNVEKREGPIEKFANHLQNWIGEDIFKKMKLQFVSKKEDKLTCQHFHQICDNKAPILIIIESEGNIFGGYSSAGWKKPEKQKSSDFYNDIDIDNDIDDKYFEDISYIEDDKAFLFLLKATQKDQQLKIELKEKESKKAIVYYSQRGPIFGDGWDLAISADLKTGYSNPGHTYQLPNNIEFDSKESKMFFTRDYGEWKVNKLEVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHP4</accession>
    <name>A0A9Q0LHP4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHP4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="185" mass="22173" checksum="2EB78EDC25D6B043" modified="2023-09-13" version="1">MRYQLRSWWLTPILAEVVAEVIGLSVVAGFFWTKGTDWFHKYYITILGYYVVASITLGHYFKTNGKPNIHGFFRHVIAILCGIEFYYLHEDLYLHWFGIDPKLLQAAHFLWIVFGFFFASFDDTFFWGFLSKWMKFNWIKAIFWLLVVWLFWYIFFYTPLVSDAKGTFQSEKFNQTLAVMQVNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIP4</accession>
    <name>A0A9Q0LIP4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_09538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIP4"/>
    <dbReference type="OMA" id="SIDNFML"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5072158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="516" mass="59706" checksum="DF3C9AC47B02310D" modified="2023-09-13" version="1">MIDFDDIFILIPLIKALIFLKNNYDILQFIHLSLPIVFLVIIRYLFANKYQQYFTTKKFRNVFNGIILGELTVPLLLISILNEMNENSSTFSNYSLFEKQMKLYVFMTSLFGFIPFFKTRFFIFGVILLCFSFIFYVSLSWEFLFVPIFGTIIFSQLFRLFSEVLSNSFAFAECIFLSEFFSLIISFFSVCFFAGFQLSFSKITETEMQGKSFVIMLTCLVIFASAGVAIFLSFFVSGIFQSRSSLFFYLVLISSGFFSVQFCFYFLFKRNIFMWLFGFVFSTRNRIILMALWVVMMGLLIFLMNLELFEKFHKKSANILIRKIFHLFLLFIMIPGILLDLNLLQLSLAVSVNVLFVIEAVRMKKEVWLSESINIFMQKFTDQRDSGDLILTHIYLVFGSSFSVWMVFFCQYNGLKSGFLVASSGIFLLGVGDSLASFVGSKLGTINWFGKKKTIEGTLAFFVGVLFCTGFIWLIDDIDFSFFGFCLDLLLISVLEALTDLIDNLILPIYFIILLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ23</accession>
    <name>A0A9Q0LJ23_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ23"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="387" mass="44428" checksum="97F5ADDF12FBBFED" modified="2023-09-13" version="1">MNFKQFSNINFEEIDENEPIVIENGSFFIKAGFGGDDAPRAVFPTIVGKPKRQVQMVGMGSKDYYIGDDGYHPRRALTLKYPIENGIITNWEDIEHIWHHSFYNELRVAPEEHPLLMTEPPLNPKSNREKTTEIIFETFNIPDFYLSNSPSLALFASGRTTGIIIEMGYQLCNSVSIYEGSALNDSVLRMSIGGKNLTDYLMKILNERGYSFTTTAEREIIRDIKEKLCYVSLNFDKDMEMSYITDPLEKNYELPDGNIITIGNERYRCTEPLFKPSLIGISQIGIHEIIYNSIMKCDEELRKDMFENIVLSGGTSMFQGIKERIEKEIIQLSPKNMKIKVISPPERKYSVWIGGSILSSLSFFNRITISKEEYEEFGNSIIHKKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ28</accession>
    <name>A0A9Q0LJ28_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ28"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="119" mass="14369" checksum="A045FCD591714B4A" modified="2023-09-13" version="1">MFSIKRTKCFFCGSMKSSQFKKYKNKFPLCTACYQNRTVKKKGRKKIFQKITKREKSIDLIKNEKNQKKNSSHTELAMEIEFEMYPKEKKTFSMRKKRNRKSQISLQTQFVNRPKSSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ72</accession>
    <name>A0A9Q0LJ72_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ72"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="127" mass="15491" checksum="C4D09D2F37C3BAF3" modified="2023-09-13" version="1">MPNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQLFEYWIYSNQIKDEIEITKEIINEFEIGIDYFQLNEAYPNLFDLLIIKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJY5</accession>
    <name>A0A9Q0LJY5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJY5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="428"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="540" mass="63150" checksum="7F35C88EC375C156" modified="2023-09-13" version="1">MNDSIEYLNQNDPNQHLKKIQIENIQKVTVGDYNESILTIERNVFAKGRNINPENPKEFINISSLIQDTNDRIIQDIVCGAKSIYLLTSNQNAYGIGNNYYGQLGFNSKTLPKTEKPILMMKNVSKIFSGDTSDHVFLLNPNQELFTCGWNYYSKLGLSSKKLPVINKLTKIQNIPKGKIIDIQSGYTYSIMLIENENENPKRKLYSCGNYKYNGLGKYEDTYEFTEIKSSLFENDNILDFSGGNTHTLILTANSKLIGFGNNKFGQLGTGDTENKLIPIQIELPKLRFNENIFNYHILCRNEKSFIYYSPFLSSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLKDENENQIEKLQEIISTKSIKESNQIFEMIYSNKIINPKLYSEIKEIINSNEKIEETMKRIYLNGNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSEESFQIFEYWIYSNQIKDGIQITQEIIDELKRGIDYFQLNQTYPNLFDLLINKFNNQNQNQNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKF2</accession>
    <name>A0A9Q0LKF2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related protein rabd2a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKF2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="312"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="421" mass="49973" checksum="9EEE09D77F06CDCA" modified="2023-09-13" version="1">MNKKSLGYDYDFLFKFLFIGDYGVGKTKILIRFSDNEFGDFPLSTIGVQFKIKTIEIEGKIIKLQLWDTSGQERFRALTPSYYRGVHGIFLVYDITNQDSFNNIKTRWIEDINKYANENIQIILIGNKNDLEEKRIISKEEGKELADKLQIPFYEVSAKNNINIDDAFYHLTTNILENIDEDENIIKYSIQNDFKQLFERKELCDFEIECKDAQNSLNKIKIPIHKLIIQNRLKINENQIKNELYSILSQNSEKEVNILLEWIYFGKVLYSNLSILKEWKNKLSNICEIEFKRGTKSFLKDLEILMNSEETKDFQIISNKKKIKVHKIILLARSELYRGMFINVTEDKTNQVHEYSNKQLKTIQSLIHFFYTDKLPKIEKSIIYEELKECVDYFQLNSTRLIQIIQKIENEKEKEKKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLE5</accession>
    <name>A0A9Q0LLE5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Suppression of tumorigenicity 5 st5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLE5"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF0">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="59"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="972" mass="112074" checksum="B984B357AF5E51F2" modified="2023-09-13" version="1">MVFSFFKKSKKKNNKNNNHFVIDVIELTQQERLSRMLHTTTPIEQSPQTLLEGFLVVGVSPKQIKRHKKETHFEPEILFQFPKDLSEGDQTLSFCFPCGVDITRIEAKHGSKDSQIGTEMTGKFFEKKIQLIGSESHFVFLLNSHKGPIFGFCVYVQSLLNHLPSFIKKDSYERQLEASTAVGKICYCILSRFSFYDLFFDIIHAIIALELLAFQNSKLVHNFNIKTLIKTTLETNRRLATSNFRKYLVNLSEEIIMKSRDLLSNKEAVIESPKKSKRSSSIVLDILKRCQRTKISSGESWIIIPLKDPLKNIIFPVPSTIQKLHASFGFEIMFSTLSVDIIIMMMKLALLEHSVVYISKDLRILTAITLSIFSLIYPLKWSGVFIPVLPSTLKDFLDSPVPFIIGMIEKITELEKNKEYYIINIDQNTFQFPTNPKKGKNPDLVLPKLPHEEILRKNFKKIKDLIQKKNKSSQSGKNSRRGGNKSWSRPRSAVKKREIHITRANQVKSYADDNLDLFFHKDPTTKQTNDFNELHQSLNAQIITDKSPSLSPKSRRSILRHSLHTYPLNMLDSSEIKEIDFDPSNVKSDPNDKISHIKKPILKNSEQNVINEEKYPFVENSNNNSNNNSNNNSNNNSNQNSIDLIDQNLNQNSNQNSNQNENQNQNQNQNENQNSNQNQNQNLNQNQNLNQNQNENLNQNSIDLIENSNQNLNENSNQNSNQNLNENSNKNSIDLIDENLNRNLNRNLNRNLNRNLNQNLIDLIDENLNENSNQNSNQSSNQNLIDLIDENLDQNLNQKNPKKNKPKNPLIERINETKTTKPKPPPSMHFSDSFTLEFSSFSATSSLLLKGLTNRLNSKEEDPDDFKISEIYDYLNLKPIEIVIQYTLKILKVYYQNLFADFRRHTVSDVSNRTDTVVAFVKESFLSTIPEKNLPFMELFLETQQFSVFCDELLSKAVNTLSFPIFNENEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLN2</accession>
    <name>A0A9Q0LLN2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Furry-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="133"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="631"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1376"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1594"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1924"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2057"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1924"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1951"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1968"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2069"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2080"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2159"/>
            <end position="2180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2413" mass="279288" checksum="94BAC9CAB2A0777E" modified="2023-09-13" version="1">MNRNLPRLILSTAFSELDKVMQEILEQSIPQIQNLTFLCSSLESNAKLQTVITTIASISQHYLSAVINGLIDWRQKLHKTKQNEIGIEPKRDTLKNQKSKLSKKKTLKLEAQEIERIKKEIYIVKETVFAFVCLKTLQLNPPTEKNQIFTDFASLVIEILKKLDAEIVSNQQIPTAEIQNTIFARDKLAELIGIVSYSNLENVSQLFLQNWDSKKENPELSIKMMRFLRLSLISPYAMKLSNNFILEIKNALRKKKRNLKHQICDSLSFILSNLVDEYHQLQSEFFAEWNKTTNEFFVMLKGMLKKSKNQAQTLSLMTSLLCCSDPKFFNSNYEDLLTQLHKLLKAKNAKHSAISSLSLLLKVLVKLKGDDSFTNVKKVLSQVFVFEKKSNYFSQDNIWDSLCGIVNIIRDWDTPFIMDNLVIDVLKSDSLEQILVGTRAFVSVLAKYESPSDLSIDISKESDELAERLNATTKIYEKIYNSFDSQLGNFLRFNQTKSLVELVQKEKLKGIEILRQCSRLIPHILPLPDKIIPILSGYVFHLDPELSQISFIALKKIIVNIPALRNQLFQEFINVSFKIPDKNSELIVFSLDKFNELLYLWIQTERKEQLIKRTKSTDFTSDEMNKVGFEKMESILLSYLCSTKVGIRKMALLALRNIRNIDSIISKQFEIDENNDQEQDLDSFITEQRAIDVFEEAWNEILQSTLVDTLAILPFKTSTQEKELIEKTLTLDNVIAQKNQSKSLWNNFLCRFAKLFCHISPRITSRAFQKVSQKMSQLNIEVLTKVHKIKNRKEFHQSLNQWKNYAMFATSISGTKDIEPNSTKQLFDTILPFLRSKSEEQKNAAVMALFHTNESASSYLLQGIEPLFKTIMTENEKSKGKKQRDSALIKIVDVLRLFTNSLQPETFEKNTTLKDEIYKFIQETSKYIVHPLNFDNPHLSELRYSFALFVDKFAILVNNAKLQLSKADRQYLFDLLSRYSGFGENPANKQIMVKMESFIKEKVKEPEKKQEYKTAFEEQEKSVEFVCSKAMATLLIGEFFNEKDLLITGKIFQWIFQLLSSGDAHIIDIGISAIQNFLTHNSKQLKAIYIEQAFCSYNEEYSSAFTIALSSVLIQEDIDISLPVAINLFLYNLGSSSQVVRKHAADLFFLFAPKLFPNDNNLPTLNQSSCSVRESYLQSRIKLSEFIALKRPDLALQVFKEILYRYDIFQQEMKKKPIFSQKIQETKQDMLLYLIPWLKLISFQDDVWSIEKFIFLLESLFMITHEDCKKSSFVFEQIWGSISIKSGNAQAVIEFLISLCISYPQSKFIETAKTIAIYLLKAIGKEIPEQILQRIQGITQENKFPLFSYLRENKIKLKQTDEEIEQNESLKSICGREASIILLSEMIDQEKEIFLNKLPLLIHISITGIESLNQIVSDNSKLLLINLVLALVINKSENLEEQKMISARNLIDQISVWRSNKNTEIEDENLDEIESITKNENEFIIKIEQIIEIFEPVYPKIRSDWPQEAFKWACRLDTNGKVTNSAVDLCTRSNQIFRYLPQQISVGQINKLINFFSLILTSSIHQEQIFWFALEILKTLDVIASKIESILPVPNFFWVSIALLQSDNPSLHQFALSLLGKFVNLDFAKSEVIINLLSKAPQQWNPPFQGIQPLVMRSLAVTTNELPAFKILSKFTLIDSDLMIENKQRKIVSNILGLLPWLCRFTNDSDNNDTITTARNISLFAKQQGFEGLSRIFSQYSTLQMKTQEEFLTEFSKEFSQIFFPKFLDYSISFLLKTAIDSENYRFEFLKILEYLLPFVSIKSETKSIDNMDPTIFDKLLKLNSTIYATEVTKILKLLIERTKTKEFSLDIGTQTLKKERYQKEQENLLEFSSKTIAEISSQTGEESDQQLLSQSNVPSIKPQPLISEFSFSQVEYKNRNQNQNQNQNQNQNQNQNQNQNQNPKSKSESESESESESESESESDDQIPIKENKKELEVNENINKSQFNQKIPVAEKIPVAEKIPVALVQPNKQSEFIYSEKQNDTEINDPAPPIIFHLILIQNQNQNKIQIQNQNQNQNLPPSYFSRNFDQNQNQNQNDDNDDDASDDENDENDDNDDDASDDENDENDDNDDNDDNDDNDDNDASDDDENDDNDDNDDNDDNDASDDDENDNENDNENQNQNQNQNQNQNQNQNQNQNQNQFQNQNQNQDQNQAISKEQLFQQQNEKQALISELSDNWSDISSEPFIESKQIVDTVEQSKILMKSLIEQYSITTQQIKNFKFTEEILQSTISQHEILPNFLQCSIICNLIIENQEPFEKTNQDLIDLAETTMQVFDDSRLIYMDMITSTQYHLTEISSANPTELKKIEKQIFISFLKQQDQFMVVIQNYLNFLINISKIYDLKDEDQFQKILIQIPKLQEKIQQIQQKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMJ1</accession>
    <name>A0A9Q0LMJ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase ulk3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_07490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMJ1"/>
    <dbReference type="OMA" id="WIVELKC"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="246"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5075139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="527" mass="62345" checksum="3BCF24851CB5F99E" modified="2023-09-13" version="1">MIREIQIMEKIKHENCVDLFFIEPENYQNVDLIYVVMEYCDSGDLNEYLRTKSSISLEEVKEIFGQIVFGLKFLYEKDIVHRDLKPKNILLQSNNNSKFGYTIKLADFGFARKIPRNFLRKSIEMDSFIGTRIYAAPEILSNIPYKSNVDLWSLGAILYEIITGNSPIQANGLDDSNRQIKDLPGKKSLPDSYLRIVPKECHDLVERLLTVDPNLRITREELYKHPFIFGKLNELKEKSIDISDLEKKIIGIAKEDFESKENGKLSFKKGEIIEIIEIYKDKGICEGKLKEKEGIIELNRIDLYEEIEDIFSINESNELNNDNDNQLINFEKRIIGITSNEYKSNEISLSRGDLVEINNINKENDSCKIQFGNQKDEIPFFFFGFYERHEEYISIPNQQNLNQQNLNQDLYQDLYQQNLYQNLYQQNLNQNLYQQNSNQDLYQQNSNQDLYQENSNQDLYQQDLYQQDLYQQDLYQENSNQDLYQQDLYQQNSNQQDLYQQDSNQEDEMSFSFINYESSQNMEMDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN27</accession>
    <name>A0A9Q0LN27_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-like gtp-binding protein rho</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN27"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="325" mass="39136" checksum="4887E50FDFE83E6A" modified="2023-09-13" version="1">MRKWKILFIGDYYVGKTSLLMTYYEKKLPEEYLPTVFESFSNIFQIKNEEIERIEENEQNQIENEQNQQNQQNQIEIENKFQIEFWDSAIHEDNYRFLQIFCQEADIIVFCFSIIDYYSFENIQSFWIPNTEKYLKNKKIVLIGTKIDLRNNEERINQLKEKNQKLITKEEGIELAKKIKAIKYFECSSFNQKGIETIFNEIALICIGKYDKKEKKKGSIFVGSRVVGKTSLLLTYYEKKLPEKYIPIIFDNFQKTFKIEENKEIEISFWDSERPEDRDRLFPLIYPETDLIAICFSIIDSNSFERIENFWIPEIEQYSPNSKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN98</accession>
    <name>A0A9Q0LN98_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7906 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN98"/>
    <dbReference type="OMA" id="NRYNIMD"/>
    <dbReference type="OrthoDB" id="18451at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057228">
        <property type="entry name" value="DUF7906"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31515:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31515">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25483">
        <property type="entry name" value="DUF7906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7906" evidence="3">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="749" mass="88830" checksum="274D1B71372C3994" modified="2023-09-13" version="1">MKNLKKLSKEQTKQISIPVKFSIILIGFNERNEFEFNFSTEKLKDRLSLAFNSRTPTFIETGNEFPIEYKIEYEIIDLSKHPNIGNDFNLIIQEKLNENENQNQNQNENENQNQNQNQNQNGNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQKNYCYRYENGECSQFWTSKEGYAVIDLTAGPCNFGKKKYYVNNPIKNEQNFFPRIDRNSIKNENQILSELTKLIISTIEYVFIPDLFQEILKFPENITIPIIHLSDHQKGDFSDGYPEFILINHLQNQLNQIAFPNQGIRVLKGDNDIFKYSTFYIGILQSLKPYLFTQNSYLLDQNMSWNFDFYIDTQELFKRLMESGFSVIIDSLLSFDIGELEKLSSYDSSYDLYKLKNDPFVVNRNYLENQMEMENEDLPISEQEQKNIKISQQKQQSTTNFNEKKSKKDYLDKFSFNKNIYQHFEKPYLFQTFFVLSLTELRMGNSYLDRISLFSTYDFGGFVLQPTEKTIFRNPYYYESKEYEKEIDLRNPNRNILSAVLSSICGLIPPYQKMSEHSQKIQHNYNFATGHTTYGPFSTINSLTNLTIKQCRMNTIGSQVYFALQIIDDVYNYFEDFWQKYFPNLKNNGNESNFSFVFPKKENSHSNEERMLLSFIRSFQQEFENILQIKNQITQYLKNNQLDKAFKSSQVYLYSVISLQKFTQTNIEEIESSFQCCKIIHQKINQSKNHISTSKKNALNYFFLFITFLSLIITFFSYFKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNC0</accession>
    <name>A0A9Q0LNC0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ragulator complex protein lamtor5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNC0"/>
    <dbReference type="OrthoDB" id="10692537at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024135">
        <property type="entry name" value="LAMTOR5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16672">
        <property type="entry name" value="LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="298" mass="35327" checksum="92D6B2C8B82126FB" modified="2023-09-13" version="1">MDEKIKNEMTKIMKLNQADGVIMTDKNGLCLARSGYFESDNLSGFIHSISQHSAELENLHFSKSKNNQNKQEMVFLTDNFQNEDFLENETSFITCIETNTSNKNENEIYQKFLSICTKFQIIPNFISFEKIFEDSIYKTTLITSMKKIYEENFKEEKNINSFVKNFFAISNPNFEILLHSQDKQIYPAILQLRPEKFHLIYQDKIFTFMFGNSQFKMIESLDIENIATLENQEEKQNIFTFQFKNKLEKEVVMKTFEMFSWYYKIEVEEHEINTKILGENDEIEALLLRCLNKGNLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNX9</accession>
    <name>A0A9Q0LNX9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tbc1 domain family member whacked</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNX9"/>
    <dbReference type="OMA" id="WIHMFAN"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="171"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="434" mass="51379" checksum="EA8BEF034DA7E0B2" modified="2023-09-13" version="1">MSNLPTPHWIDVAIGIVSSDDDFEDDFTKSNLRTNQNQNQQKNSPYQIELTQTTEKKASYDRYGFEITKNTDEKIFLHLLSRVGDEGNKQFSNESETSKAITNLLDPEEWNPKKRKYTPSKYTPSKNFRKPTKKEIKKELSRADKWIHMFANWEVYTTKKIKILDRRILKGIPDRVRGEAWKKIVGSDQLQKSKPNLYEQNITARNLTSEKIILKDLDRTFPEHQLFVQRQIQQKLYNVLRALANYSPETGYCQGMSFIGGLLLLYMEEKEAFYFFVKLLDDYHMKGIFQAGFPLLQYQFEEWKKMLRSHCPKIDAKLEENNVEPSFYAMKWFMTIYSNIRDFSGMAQVWENYLFRKNEFLFGFTLSLMKLSEKKILKMDPSYLLQQLQDIPNDFPISKVLEVYKKIKLSKDEKNRIQNLANNWLTQNGNSQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNY9</accession>
    <name>A0A9Q0LNY9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNY9"/>
    <dbReference type="OMA" id="YNEETRC"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="233"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="559" mass="65130" checksum="438F39DA3716C5FF" modified="2023-09-13" version="1">MDPKIQNSLITAIRRQQNNLATFASFSKKYTLLRAFLILFECPLFWEPEHLELFSQLISSVLALPNEAQVILKGWWKSIYTTNQYQPVVRLLQNFVTFRILINEPIFSIFPGKHVEDALKVLQILYSVNETRTKEINYTEFYNDAINERFKVRKNFNAWVYGEDFSYCNYPFLLNSLTKSKLMAVESETQMNNLVRGAIFESLQSGQFMPFFMLRVRREHVVEDAFNIISATPSHDLKKQLRVKFEEEAGVDAGGVKKEFFQIIVRELFDPKYGMFTYDEETHFYWFNRDSLETNSEFFLIGAILGLAIYNQVILDVHFPPVVYKKLLDKKPTLEDLKIANPDLGRGLQTLLDFDGDIKEVYDRNFQIEYESFGQIKTYDLKPNAENIILTEENRKEYVDLYVEFELVKSIEQQFNSFHRGFKEVCEGMVLSLLRPEELELLVCGDPIFDFSALQAVCKYEDGYTATSQVIKWLWEILSSFSIESQKKFLFFTCGSDRVPVGGLTEMKFVISRNGPDSDRLPTAHTCFNHLLLPEYTSKEKLREKLETAIKNSEGFGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP78</accession>
    <name>A0A9Q0LP78_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP78"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="206" mass="23869" checksum="D03386849760A663" modified="2023-09-13" version="1">MITSQQNPRLNFLKTSRLGYIGISFGSLLFSVINFGIEEGNVFQIRWFFLFPAILLILGALSNFHERKLWETSFFFIMSTFWSILCFTWTHNVWDYSIPLKGAVLKMITGFLVLICFYLALIAGITLQSNKLIFWMTFTIALGIFFTILKVAYNVNSVLVGLPFLMVFILSFYIWLALFLGDLAGKYVLPFGNPYWDWKKIKLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPV2</accession>
    <name>A0A9Q0LPV2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_07293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPV2"/>
    <dbReference type="OMA" id="SWINIRD"/>
    <dbReference type="OrthoDB" id="28186at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040416">
        <property type="entry name" value="TMEM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054077">
        <property type="entry name" value="TMEM181_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21885">
        <property type="entry name" value="TMEM181_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM181 GOLD" evidence="8">
        <location>
            <begin position="72"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="7">
        <location>
            <begin position="172"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5075323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="504" mass="59497" checksum="8C2AE71DDA3378C1" modified="2023-09-13" version="1">MHPSEMKMRAESFTKKKQVFVVVAFSVYIFTSIIVGLIGPSVLTTREAEDNLTPTSHIGLWQSIYNLDRMNLDLMVSVEIQNNKEYQIETPAKFILDLYGKSSENGDKKEIVLNDVHTRTIKCDSHSKCDSIYFIHETFIEYSIYQFFIQIEPDTLETELFSGVTFKFEFYNTHFVMFRMIFGFVYVIFSIFVLLFWTYKTSKISWKVFTFEQKWVTVLLFALVFFNNPFFPITIIGRGWFPEFLDVLFILVFVFLMLLFWLVMFDSFRFRPEERTFTKFLLPKISILFVQFVFNFALILIQRLHLKNDPEYEEADDLKGYKPLAIISIILFVVYLLWLIYSIYRAFREIHQFTNWKPVFYFFFNITIIDIILFAIFVGVGTLHSEKSNPLVFLATYGLFNFYIYTLAIGFFPTTESIDMIRGAARQQLGDDEDEIDKNEKQNQQITSSDDNLRGDDIEMDQVNKVNQKELNQSEKSEKLDQSEKSEKLDQSEKSEKLDQSDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPZ7</accession>
    <name>A0A9Q0LPZ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPZ7"/>
    <dbReference type="OMA" id="ARYRGHQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="408" mass="49636" checksum="3241390D7924834A" modified="2023-09-13" version="1">MNSNDEISQFFQDDYDQTNFSDDINFSDEETKKNQKRKSNDNFNFENQNQNENENENQNQNQNQNENENQNQNQNQNQNQNQNQNENENENENENQNQNQNQNQNQNENENQNQNENQNQNQNQIENQNQNQNQNQNQNQNQNQNENQNENQNENQNENQNQNQNQNQNQNENKNQNQNQNQFENQFESNFENENQNENQNQNENQNQNQNQNQNENQNQNQNQNQNQNQNQNQNQNENENQNENQNENQNQNQNQFENQFESNFEFDNNFYTKFDDNFNFENENQNENQNQNENQNQNQNQNENQNQNENENQNQNENENQNKNQNENQNENQNENQNKNQNQFENQFESNFEFDNNFDTKFDNNFNFENEKNIQNENQNQNQNQNQNQMKSKSKSKSKSISKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQB8</accession>
    <name>A0A9Q0LQB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Csc1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_00052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQB8"/>
    <dbReference type="OMA" id="PKRYYAH"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="356"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="732"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="804"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5076735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="851" mass="99183" checksum="2F2DB91F15072192" modified="2023-09-13" version="1">MIQDGGLLFVIVLDAIILFLMLLCFQFKKNKPKQNRQTKLKENEEIKEEKKETKEKKGFFKWIITTWKISNREIYAKSGAGSLNYLKFQKATILLFLFFTIFGVAIILPINVSAKNLPKNEIGLGSTTVNNISSQSRRLWAHWVFQILYNIVILLYLFFLYNQLTIKTNDVKHQHLLKSLKKKIKPSHFTILIENIPSNITEHDLFNAFNRKYPNEVISCYIAKQMNPYLRFRAKLIQNLDKLNFLKDHKAKGNAQIGEYFCCWESDQDLAKRIATYEKIVKRYEELVENKGNVVKQAQVGFVSFKRPSLVWVSLGDHKRSPVLSSEMRMTPAPDHNNVMWNHISLTKKGRTRISILVYLGLFLLLLIYSTPVAFLNALRKLTQTYAFRKLEDNFMLLGLISSYLPSIASYLFTSVLPGIIRSAANKTAKFTATKQLSLIMRVDFIMMFFGLLVLPVISSVCIYVAVQDYIDSEKSFWSLFSQAFVSDNGATFMNMILQFAVFGCGLELIQAFDVYHSWKMKKHARTPNEKNQLPKKIENSRTFDFGFNWALQTVIISIVMLFSIMVPLVSPFGFFYFLFKHTVDKHNMIYFYNVKLHSFGEMPSSAISQIFIGLSFMNLTIAGFYGVRNLWFFFYSSVFWFVFSIFVHFYTWRKIATFRNKIETEMLICEDHDNESFPSEEKIKKSYNYYDILTKNETKLWGDLPQSHHLLNHQKLKTILDVRGFSQQNKIDLEKTSDSTSKSDSDSDSKEIQKNNSFKEIQNEKFDKKNSKEISIETSEDESEKKVQENQDLIIFTDKNENENENQNENENENDNDNNNENDNDNDNDNDNDNDNDNDNENDNDNDNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQG3</accession>
    <name>A0A9Q0LQG3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQG3"/>
    <dbReference type="OMA" id="ACDKNRI"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="320" mass="37324" checksum="58253A0D3B5E82C1" modified="2023-09-13" version="1">MDVSSILNKAEKKPLHIPEKNDDLQYDIGNLTTLDSLSINSEEFLKDVDNNIKDLTRDNAQLLINKLFQIEGELTDTGVVIQLPDPTTKIPREKPVPEEKPLTKWEKFAREKGIKKRKKSRKVWDQNKQQWGYRSGYGKANNEMDEVIIEDKGEIEAEDPFLQRKQNKQKRIQQQKKNELMNIARSKNGKVAKQTERVIEDLSKQAGKRLTRKQRLQKMFRVVQQSTASHGLFDKRVKNEPKVKLSKKQQFNSVTEPDLKNETKNHLDVLDRILDHTDVSINLEKAINQFKDTIDDADIKPKQQKKKSKSRKPRKPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQJ0</accession>
    <name>A0A9Q0LQJ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Atp-dependent RNA helicase ddx49-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_00497</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQJ0"/>
    <dbReference type="OMA" id="IMIFTDT"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="33"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="261"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5077177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="475" mass="54170" checksum="DBDF743871240B70" modified="2023-09-13" version="1">MTTLKELGVNNWLIKACKSMRIEKPTYIQKCCIPSILQLKSVIGCAQTGSGKTAAFALPILQILANDPYGIFALVLTPTRELAIQIADQFKAFGSEINVKVATIIGGMEITQQAALLANKPHIVVGTPGRIAAHIQNSPLISFRKLKFMVFDEADRLFENKTLMKPISQILEALPENRINLFFSATITEKILKLQEISKTKIEVFMDNEDEDENENENEKNNLQNQDIKIKTEKIVYKIPSTLKQQYVFIPKYARECFLLHILQKFEKYGQEKHLSPFLVIIFTSTCLMSHETNLILKKMGIKNVPLNSSMPQRNRLESLANFRNGKIPILVATDIASRGLDIPNVELVINLNIPNSPIDYIHRIGRTARAGKNGFAISLVTQFDVERIQRIENFIGKKLDLLEVNETEALKFLKPISVSKKMAKMALLYPKNSNKQSKRQKLHLKKRRQTFLEINSEEQKQRKIEIEIEKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQS8</accession>
    <name>A0A9Q0LQS8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dedicator of cytokinesis dock</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="TFYHLGC"/>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF76">
        <property type="entry name" value="LD20667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="5">
        <location>
            <begin position="512"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="6">
        <location>
            <begin position="1411"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1843" mass="213885" checksum="35998E78F75238EB" modified="2023-09-13" version="1">MSLSRSTSREKKMSKGNSKKEIKETKETNETEENNETEEINEKNKITRNYYTLKRSEIVKKDSFSSMLRIPRDDLSVDIRDRELRVLTNLTEKEDLQKLPLFIQDRYKAFFDSWVFVQRKYRTYQKKKEVPIIERKFPEQKFEVDHELLKDKKYKSIQEVRFEDGVPINKEEKPIKLTEEDFEYEFIKSSDSQKSHLLNVEKRSKHYVNIFESFSNIDIRPVVGDPRSPSIAFRDLYVNQLFVHPISLEFAIPEEIEPFFCTLALYDLATQSKLSEDFHFELNKPNLQKMTYYDKNYDKTTIVKNAIFSFPNPSKELVFILRIDQVLKGSYDDTIDPYLKGKSISTRKLQTLQKTYPEIFANFGEYRQAFAWSFAPLFKMNALSNQIVDLFGEKEDFQFTSLYKTKELITDEKIFNFILNEAGGSGKKKTIPGSMKMRVARLEKNSEMIKDKLCLDPSLYPVALSEEFMGDMDGNVWVDSKLSTTLNRDSVSILEIQNFADMAKQEPKLSYVNNLYIYPTQLMTTVKKTYVIKIQLMEDDSNLNGSGMSHFYGVIRQKKFVNFRYTKANFQKKAPKFHDEIKLLLPQDITEKHHLLFTYYHAHCKEKKPKKIADVIGYSVLPLFDPNLVIEREIKIPILKELPNEHYLEAIQESGEKMKQYLDLRLRAVSSLYPQDGDIMGLLYYFGKKGNEAHQKLMHALERLRTTRVANEEMFHYFPTIFSIVSQLMCGFGVIPSRNSRDQQWCVLRLFHAFASVAFAIQNDQKHVDNLKIYIEHLFKNPTDYSDLFAHVAELWRAEIDKLNMETTVESSGSPFVNPAWFFYEVVIKSAILFLEEKDLLRHDSRKKYKALSREFLKNIRGLVQGVQTQVLRRMSTGLTVAKRLNRATALFLKDLLHIYNIEEVFELMQKYIRGFSGNEDAGSRATFKLDFLQIVLETEHYFALNIPVCIPFETSTTNMAVILSERHFLVGLLLREIFTIIASSHGEDVAQTSAISLLRDVLHKHETDPRLQEKNAMGRIGALYLLLVVFFIDNIAVCNNMSQDSQRNLLVSLVFVLRYIDSGYFLDWWGHENMRRRLVFFDLLRLCITVFEYPGLKQLRTLSEKRLQESPTMRTAELEDVKERLEQRYANSAIMSFRDRTPTDSPTRRFSSFKKTTPKQDVWSDDETSPQSKNTPRKLFMTYTLSNRPVVGDNTQMEANLSVQVSLTILNIIETLMVNLHSRLSADDAVQDSSVLKNLFLTMIKLFETNQSDTVVLALFASARLFVRLYRDSVFAQNNSLLQTLFHKTFAKTISPSKSVRCRANAFAFLLIKTNFKHSRNISKSEINSIIALSKLVGDPAKFQDDLSIRSAFLIMQQYASKEKLGKGQFNLLVKKHSEELTSILRDGAKLAKCQHDPEMTAELYLKIADGYKKAPDLRLTWLESLKNFNTKHENNMEAFVNGIHMCALVGEYLRTTRPECDWIAQGALTFENIARSCAEELFPRDVVDIQRLAHSPSFTTRWLELLLVSISDLANRSGFYEAKFRTDKLVMQIYEQRLDWNSLASLHSDLQKVFQNLAAESANNIQNRGFGAFYRVAFYGDFFADLDPNQFIYREPDFTHLFTLAEKLTKQYERSFGTGNVEIIQKSQDVDPKKLQPNRAYLQITSVEPYFSDEENIPRVSRFQRSFNLSKFFFETPFTKSGKPHGNINEQYLTKTILSCRGTFPYLIKRLPIINKKQSTLSPIQTSTDNMKKKNIQIQSILDSSLKNINELQSLLNGTCLASVNVGPAEIAKVFLTNPRDFPSDDVKMLISEFRLFFLNLNLLLKEHERLANDDARPFHEAVVNGFDKLKAQVEPFLDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQW3</accession>
    <name>A0A9Q0LQW3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQW3"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="351" mass="39954" checksum="2F532C9ED3D56D7E" modified="2023-09-13" version="1">MNEILFFGRNKYPKLIKNEPNLITKPIQFKFENENENENENENENEKQIKQISTGHFATIFLFENGKAIEYLKYSKQNPQKIQIEENIQKVTVGVENEAILTIEGNIQNDRIIQDIVSGSSSIYLLTSNQNAYGIGSNEYGQLGFDSETLPKTEKPVLMMKNVSKIFSGISSFYVFLLNSNQELFGCGDNRVGELGLGESRKEYYITELTKIQNIPKGKIIDIQCGYLHSIIKLYSCGNYKFNGLVKNKGIYEFTEIKSSLFKNDDNILDFSVGYDHTLILTSNSKLIGFGGNLYGELGNGDTNDQYIPIQIEIPKLRFNDNISNYHISCGYNNSFLYYSLPPSFPILKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRB6</accession>
    <name>A0A9Q0LRB6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_05667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRB6"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF263">
        <property type="entry name" value="PLECKSTRIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="289"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="502"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="650"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="808"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="956"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="927"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1091" mass="127344" checksum="F92351C4EC1B4539" modified="2023-09-13" version="1">MSQHWEKVQIELFTSWCNKVLSKRNLRLIDFETDFSDGVLLVNLLEILTDKTIKHFKNPTSVYQKLDNITQVFKVLKEYNIQILCAPYDVVNGNVPRILSLIWKVILFFDSNQRSIKFHYSKKSLNLHKKLNQEDPKQNSFKNSKEDLFKNSKEDLFKNSKENSFKNSKEDENKFDNLDLGFEVQVVEEDDNDNENDNNIENENDKENNIDSDKENNKENNIENDNNIENDNNIDNDNDNNNSFNFNDDDFVLISSFSQSQIINDSIQEQKNQKEEQIEQEKQTKQKKQRNSLVEEIYNTEKTFVENMELYLKIYLKPLQNEFRGLISTEHFKILFSQVQVILNYNKELLIELEKRWQKDKYEMILGDLFLQMSYFFKTYTQYVTDYNNSLDILSDLKKKKSFDKFLVTQKQKPEAKGLDITSFMILPVQRIPRYVLLIQSLLEKTSLDHPDRANLEKAFSKIKDVGDYLNEKKREAENMLQVICIQSIVKGVQNLAIPSRRFIRGGKLKYLKRGSQIITCYVHLFNDSFLISRDSGSKLAMIKFVPLGSHFKIGGVLSQKSISVYPEKSPKIVPKSGFSFSIHDKEKTYLFYAENETQQLEWIISFDDILTNYLNLLTSLSKTKRKFSFILHPEVVVDSAIQQNSAISRSIKHGTVFEYKDISFLEERKSRILYLLPNHLLFFQSQDSQKPLRIYDLQESSISLFPDIPNGLKIVNQKSITYISARNSLEVLDWLNMIRAQIADSLIVDKKNNQDLTKSSLSPKMDRFQLSFSMVGDFQDIIPTNINQLRRSKRTRTIHEILVAKQQKMTQQILQNNPNCADCCKENPEWASLATGMIICKDCALIHSQIPQFSKIRNLKCTHHQDHFIEELEFILSIGNTKGNEIWEGNIKLHEGSKPKSNSSVKSKLDFIYQKYVNRAYSQSSANFQQENEQNKQQNSEENHANNSLRKFLGKPLKEGYLDKQSQNPAKERKKRYVVLHSQHLLYLKDKNSSEISREIDLSLALVKQHKSSSLPNQQFAIEIVSLNRSFIFFAKSGIEMFDWIQAIRQSIDSQKNFENDHDQNDDNNKIILKEIQSNMDSGNIGKKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRI7</accession>
    <name>A0A9Q0LRI7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Wd-repeat protein bing4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRI7"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BING4 C-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="173" mass="20161" checksum="DB8108D7DB2F927E" modified="2023-09-13" version="1">MFSPFEDVLGVGLSNGFQSLIIPGAGEPNIDTYENNPFATRKERAEQTVKNLLEKVPSEMITLDPNFVGNVADSREDITLQKNKINFEANNPTQNYQRPFISQTTRLKRKLKRKQKNVIDEQTLKLQKMIEKRRIANEKRSIQAKERKKKQFQEQDVEKTKTLPALQRFLRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTP1</accession>
    <name>A0A9Q0LTP1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTP1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="65077" checksum="2D7F9761F0C62A6B" modified="2023-09-13" version="1">MFNEFTTNKTINHFHTEQDSDSNSDSDLDSNSNSYSNSDSNSYFHSYLHFHSNSYSNSDSEKEPNSNLKELEKSLTELADKFIKKSNPNPNVETEQYSESESKNRPEPNSNFETEQYSESELESEIESEIESESELESKTYYKNKSQTDFQLRKELTQELKSPLYLNSYLYQESESESDQELNQELNQELNQELNQELNQGLEELKKELEQELPEEFKQKLKKQSKKQSKKQSKKQSKKQSKKQSKKQSKKQLKKQSKKEIESNSYSDSDSEYGNELFEEEKNVRKLLEAKRYTECLNYLKNGNLKSSKLPFFYLSYARCLIVFGKINKAIKQLYNITIHNQHIPLSTIYFLFSKCFYKKKNYEKSQKNIQKAIENKPNEREFEFFSIKILIKQKNFEEAENELKKMFINRYSYYYKIYLAQIHYSQLKYSFIILNQNHKLNIKENLQKEFKENFQKNFEKLEKELIEITILYPPTNKSQYLLAKYYSFKKEHYQAAQKYYFANIIKSKSKYLYGIAYENKFIEEYSEALISLECIDLTKQKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTU3</accession>
    <name>A0A9Q0LTU3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTU3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="363" mass="44070" checksum="53D156424446B52E" modified="2023-09-13" version="1">MQIIHKLTSLFFTKQFKTILFKIKNIFILFFLFKKNLISKNIVQLAKEKAIWKTIRMIIRSDKRTTSEFEIKNQERFRNHFRKDSNQSNLKKKRISFFTFELQCHLLKLLYFGEVFQGENPRYTFQTIDIWNKNIIKIHFNLFKLFERFIIRFLLKNYQKQVFIWKLIQNQNILVIKINYWERFSNIKQLFGECSTICKDDLYLFQLTQHIKRILYIFSLFFQNLSKGASFENETEYLSPLDDLLLKYMFYLQEIFHFHFFFASIQLLLTELGKILSTEKQKIEKPKEITRVESSLLNSWLDNLTAQLKTPLFNIKQKIRMEKDILMFLLNLLILKKNSFVLVPKQDEKDRTIISCENKQDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTZ5</accession>
    <name>A0A9Q0LTZ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Necap-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000052">
        <property type="protein sequence ID" value="KAJ5078646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTZ5"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000150">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="3">
        <location>
            <begin position="11"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="477" mass="55514" checksum="71A527B3723F12C8" modified="2023-09-13" version="1">MTDDWDEDSNVERTLLTIRESHVFKIPPLQTSQGYRCSEWEGNHMWTGRLKVVAKGEDCTIRLEDSESGKIFAQCPVDTSNNQSVIPAVDSSRFFVLRIEDGKGHHAFIGMGFQERTDAFDFNLALQDHKKEIERKKNPPKFDGPTEDLSLKQGETIRINLSGMPTTTSTKKAKSTSKKITLKPPPKFNGTKYFQLKELTPKIEKAYEVAIKITEETNSNIISIETIFDRIFKAMNRLTLLETELEHQINISTEIIKGIEERSNLMKVLVEKNEKNINDASFALEDIFNQLRLKVIDKRMLQTNKQKSNINLDKNMSIQVQNQNLNEIQNLNENKNQNQNLNQNQNQNLNQNQNQNQNQNLNQNQNQNQNQNQNQNAKIINGVFDKNFFAEKENMQNNNFVDQFELKKRDNLRDLKMQFENQNQEINHDLKKKNQKELEKENINRSKNIDEQDLHILFEYVNDESVAQVEKTGKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU92</accession>
    <name>A0A9Q0LU92_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000036">
        <property type="protein sequence ID" value="KAJ5079142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU92"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="216" mass="25561" checksum="F3A562396A957B95" modified="2023-09-13" version="1">MTIFVKNSQQNPFKLKVLEGEVVYDYQIDFTTNFVKEGKDTTIIVQKKKLKESPKFEETNEKQELITKLEKQQKQQKKKEVKCGCYKKKQKFKLQHFITSVHLLIQIDTKIHFDSNQNFLIKEGLFEYSGLLNGEIYPVFRIKNAQGSVRFHHKEKLRFMDLSLSFSEVILDRRDSLLKQLGQEILDFEKIEENENEIEKQNKVVVWGTIPITNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUZ4</accession>
    <name>A0A9Q0LUZ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000034">
        <property type="protein sequence ID" value="KAJ5079195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUZ4"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="525" mass="60696" checksum="90DEE6EFAFA79318" modified="2023-09-13" version="1">MQNEIKNQFPSGNNFKAKRKIGKGSYGTVYLGKTLKTKEICAIKKIDLSQTENQEKTRRNVLLEIQIMKKVKHENCVKLFFIEPENYQKSDLIYVVMEYCNMNDLNHYIQSKNKRISIEEMKEIFRQIFQGLKYLYEQGIVHRDLKPENILLQKNDSKFGYTIKLADFGFARKIPKDDLGKSLNMQSLVGSPIYAAPEILFGESYTSKADLWSLGVILYEIVTGGIPFSAFGINDLVLIYKNTTKKSLPKKVLNVVPKECNDLVEKLLTVDPELRISRQDLHNHPFISEQLKESVEKSQSLLDLEKGIIGITKEDFESKENDKLSFKKGEVIEIIKIKKDKEICEGILKEEKGIIELKSIDLYQKIENIFSIIESNNQIKKFQKRIIGITKYRYQANQFSLPKGELIEITLINGEMEICEIQFENQKDEIPFFFLDFYEQIGGNNGNQNQIQIQNQIQNENQNENQNKLIGIARVDSQDNEDEHFLSFSKGDEVEILEINEKIGIAKLNGKEGEILIDDFDIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVC4</accession>
    <name>A0A9Q0LVC4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leukocyte receptor cluster lrc member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVC4"/>
    <dbReference type="OMA" id="VWRRDNI"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="306" mass="37375" checksum="5E8E9A1FF4C4EA9F" modified="2023-09-13" version="1">MSLNILPHKNWNVYSLKNIQKVKEDERKFKEKEEKKQTKKEQIEREARYETLLRKAGIQKKQEKQIPFSIEDLKTNHINLFQENPNLINKETNEEYEKEKKEEEKKLVQKLTTFLGQSSVEMKKEKPWYQQTQNKEKNISLIDERRKQQDDPLSKIQRSLAQRKLQKDEEKNQEEKNKTPPVFFSPLNSHSLWDQKPLEKERREEKKKRKKNKHKEKEKEKKKETEKKKKKHRKSRKKSDTNQELLKLRQERLLRESQEREKIEKLKNQLTNQNNQNNNNQNRPQQTIFSRMVRMETGGSRLRSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVG1</accession>
    <name>A0A9Q0LVG1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Defective chorion-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVG1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="433" mass="51224" checksum="9068EC9D968F5710" modified="2023-09-13" version="1">MHPQNSMQPMQQMQQIPQRLHLFRWTGDSNQNLERFKRNLDILHYGFIEQPKFRYFWFYLKNPSFVYSSPGLGFERASTIYLKCFRCKNPTPAHLIFNCNNCKTVYCFKCAQENAFSFGMDSKCDHCSKPLFSGHPLFSDSLINHASSISFNEAQNKQNSVNQDLQKYRDKWQQQMRPPQQILPPQQIPPQQIPPQNNQNPNQNQYQNQYQNQYQNQNQNQIQNQNQNQYKNQNQNRNQIQNQNRNQIQNQIQNQNQNKNKKKKVKNSNSDSDSDSDSDSDPKSKSNSDSDNEGNQSKITLVGIRFIIPINSQGRCPYWEDPNTNWCHLWDHWKNRSSLENLHPLDQCICPYLNRCNRYSRCEFRHPNPTRGDLQKAHSTYNGDPNKLQSKKYHSLYRDTRPSKIKQLCPTYSQSRSCPNPDCPFEHVDQNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVN4</accession>
    <name>A0A9Q0LVN4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVN4"/>
    <dbReference type="OMA" id="WMTYKTA"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF13">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5079732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="513" mass="57196" checksum="099F902EF64B55AF" modified="2023-09-13" version="1">MLRCQKIPTKTISAINYLSKQQRKSTITKNIFLNHFSTTKTIESTLKKQVEKYYDRAAGFVNHNSGLLGYIKQCKSTLSIILPLQVEADNKKSDFKVIEAYKAQHSHHKIPFIGGLMISDNINLEDIQAHAALKTLQCACVDIPLGGAKAGIKINKKEFTDSQIEKILRRFSSELLKRRFLGPSVDVFRPELGSGNQEMDWIQQMYQTFRPEDINRASVSTGKSPRTNGLQISYDPTGLGIFFATQEVLKDVNEMAKIGLSTGIEGKSVIISGFGAVGYSAAKSFSLRGKAKVVGVSDSNGAIYNADGFDIEKLREWKNQTGSIMNFPNSEQIENPQDLIFKEADIFIPASSVAEITGETAPKIKARIIVEGTSGGCTLEGEEQLQGRGVLIIPDIFANSGSVIASYFEWLKNLTHVDFGRMTTRYEENSKLTLLDILEKKFSVKFNDKEKEIIIRGGDEEMLIETGLEHIMKTTFKQIQLTAKKFAVNYRIAAYINSIQKVADVYTELGIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVQ1</accession>
    <name>A0A9Q0LVQ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiol protease-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000028">
        <property type="protein sequence ID" value="KAJ5079531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVQ1"/>
    <dbReference type="OMA" id="IAINAEW"/>
    <dbReference type="OrthoDB" id="387093at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000103">
        <property type="entry name" value="Hypothetical LOC496748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040406496" evidence="3">
        <location>
            <begin position="21"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="5">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="114"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="326" mass="36811" checksum="9C2C76BCE236EC66" modified="2023-09-13" version="1">MISRLFLIVFCASLLGLVYSIDLQEAKTLFKDFQNKFEKIYETEEENEYRFQVFQENLEIAKNKNAKQELTHFGITKFSDLTSEEFKSIILSEFQPIYGQNARKYEKKDELRALPDSFDWREKGAVTVVKDQGDCGSCWAFSAVGAIEGVWKLSGHDLVSLSTQQLIDCDKNDSGCDGGWMLTAFDYVIANGLETDVDYPYYAYKRTCVYDQKKVLAHISNYTTVAQDETVIAQYLMDHNPLSAALDATDLQLYDGGILFPDQCNSGEYYLNHGILLVGFGTSGRVTYWICKNSWGTGWGIQNGYFLIVRGINACGISDAVSSPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWG1</accession>
    <name>A0A9Q0LWG1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWG1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="95" mass="11459" checksum="2BC639C0DCE9C8FF" modified="2023-09-13" version="1">MRSELYRGMFLSVKDDTSNKVTDYSELSNKSFEIFEYWIYSNQIKEEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQNQKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXD9</accession>
    <name>A0A9Q0LXD9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000023">
        <property type="protein sequence ID" value="KAJ5079635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXD9"/>
    <dbReference type="OMA" id="FMDGGAW"/>
    <dbReference type="OrthoDB" id="1932795at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626">
        <property type="entry name" value="ZGC:158463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="122" mass="14193" checksum="85CEA02A8C0B3813" modified="2023-09-13" version="1">MDISLKLKGIDGRAPPGVELLFHDFMDGGAWPFLVRGVICLQQQVRDALRCSGLHTCYNVNNNKLLKLLILNKEFLVNVNHNFTLITSLPFVHTARRSYRLDNPMKFLDYFLKIIFKKWKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXS2</accession>
    <name>A0A9Q0LXS2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol-4-phosphate 5-kinase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04271</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXS2"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="425"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="4">
        <location>
            <begin position="538"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="610" mass="72140" checksum="59D8D27C483B163A" modified="2023-09-13" version="1">MTLKKEVKVYHDRSIYEGETLNGMRHGYGVYRYHSGERYEGHWFLDKKHGRGKYFYTSGGIYDGEWDFGRKTGKGSFKFPSGDLYDGTWKSDKRDDFGIYNYSIGDRYEGYWYEDQKHGKGYYMFSSKSEYIGEWVFGTKEGFGRFNFNTGDIYEGRWKNEKRDGFGVYHYGRDLDRYEGMWRDDAKHGKGFYLYKNGDWYYGYWNKGKKQGMGIFHYADNGSEYIGFWDDNYRHGFGINYFGNGDVYRGYWRKDRKDGEGDYFYSNGDRYQGGWREDQKSGFGYYFYLNGDIFESFWYSGLKHDPEAKFYPGNDTSKVIIESYSDGVQKEIKETRSATKRPSFIPRFEMEESDLKKFLDHRESRNERPEAVIPSNFANKCEMVIRSCLFSKQDYKSLITENTRAISQMEHNAAKHFSDLNFWEWSKEQVSDWLDLLEIVSIKPLFLQHCIDGYCLQFLTESDLKEMEIYDLDLIQKILKETQNLKENESLPKNFQNSHLGQKDNSNLTSDINSNHVENDLRSIPDSFKKRLEEKNINIPQEYICPLSKELMQDPVILSDGYTYERKAIEEWITKSNYSPVDGSLLSDIKLKPNTALKELIEIFKDNVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY06</accession>
    <name>A0A9Q0LY06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sorting nexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000031">
        <property type="protein sequence ID" value="KAJ5079508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY06"/>
    <dbReference type="OMA" id="FAYTDRY"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="289"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="677" mass="78363" checksum="A3814C3168E0A56C" modified="2023-09-13" version="1">MSKFAEVLFDYLPQEAEELELHAGDIISIISEDKTGWWTGEIEGQIGVFPGSYVKYLSQKEIDEILKEEQFQEELFQNQGKTSETKKEETKKETKEEETKMNFSFNEKKTSYSNNQNKSNTYSNTQNTSNTYSINQNQTTSFSNNQNNSQNSSPLNNNESNNPFQKVTYQTQNAPKTKMPTPNNNNPFYQKTIQNESKNDSKKNSSVSIKKVTPQNSKFKTKSKNTSNSNSNSNSNSNSKFSWSNKSKSNSNKNQKSKSPKITKAVPVNFKMDEKPQNVNKDHVWNETHTFFKIEVVSAEKRTKYKGFKKYTSYVVRYNNYTVERRYKHFYWLRERLWERYENIVIPPMPEKQIGGRFEEEFISRRKKELERFLNRIAEHPVLRSSSILHHFLTAEESKVWKAGKHAIEKELKTMKPFFTYVKTTLPNATQNDEQNITKFQDQNTSFGKNLKSLESIADELFSKHYNEMGDIYNKLGFSYLSLANNNNLGLGWKPNCPITKSLEDALALVGKHYNDIGNLWKLKGQLETQDVLLKLKEYHKFAEAFESALKSTGKILSSFKSAQSLQGKSSPSLNSPSPNTSKNVSQANKIKSQNKLYRKSMSVQMSVENFAELQQKANIMTHITLTEIELFQKNKTNDLKQILNQLVQTQINFHSQVCSLWQQAQHDLDSKIFKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYV2</accession>
    <name>A0A9Q0LYV2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000020">
        <property type="protein sequence ID" value="KAJ5079943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYV2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="113" mass="13447" checksum="A899C5606A251114" modified="2023-09-13" version="1">MKHEAILSHLVDQCLLSNDYPVFLLTIPDILELSPPIYYLFQSRYDCTFIVSTEEKMKDIWKFLRIFHKNYLKIAHKSKSYLTPYQFLHSAVNKIRQMIDGMIFIFSPILTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R436</accession>
    <name>A0A9Q0R436_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R436"/>
    <dbReference type="OrthoDB" id="2157354at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="985"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1026" mass="119219" checksum="A7929CDDDE425681" modified="2023-09-13" version="1">MDFEIFSTFQKLLKENKIESIQNFLKENELTQKQISKCLTLSLINRSTPFEVIQLLIKSGANINYKTLKSRKTALLTAIRESKSSEVIDFLIKSGADLDAKDSKNRTLLFYIMRHLSPETGSLISYILEKGARINDKDNLLQTPIFYAFINKQPIDIIKLLIEKGADTNIYNFYGENLMDICAKYNPNIELFQLLIDKGVEINEKDKHFKNSLTYLLQNYPKNIPEIKFLVSKGASVGKSLFPFVMDPKYFEIIKFTLSLDSSLINEKNFLQQTLLHRACFTKNNIKTIELVIQKGINVNAEDYFGNTALHFACQNKLENETIKLLISSGVNPSIQNCYNRYALQYFHKWDYSENPERSETMILLFKGIDFTAKNMPRLSETEWKNLFNNSKNEEHNSEIIKIIDKITNLKRTPPYYSVQISIEKLLLYSYKNFGIFKFLFEKSLKSGEVNFTSVITCISHSPDSSSLIKYILETLSKHPEMNVDINTAFMSFCRSTHQLENFELFLKNGADANYKDSYQNTPLMMACHYSPSMFKIDFLIESGADVLAKDYNGNTALHHFCKSGSSSFQFVDIPNLMKIFKSKGLSIHDKNNKNEDALICTCTNFHVQDELIRYLIEDGADLNSFNDSKMCAFSLYLQNRNHSLEVIKLFIEKGVKKEIIQSSFVNWIRNSDAIRDCHPLETFKFFLENNLLENKQKIIFDNSQVLHYLIDIYSIKEDELNDLLGFFIKNGANSEVKTNRNENLLHSICSKHPSFVQLVKFLLTLNLDVNAVTNSKETPLSIICRSSNQAELIPILLSQGANPNYPQNCIDLIRKNSYLLRSNSSYREYLLWYGAEDNDQQENNYYTYIFSRLLLQTYKSYQEDFLKLFKRKELTDYKIQCKYGFILVHKLIITSRLYLENQSEKEMFQKFLNFAFETPKQEMEIIVEFLYSGIIEMNNYEKHFQLLEKFAQNLGFSKNWIIQKSGKIGLIHDLERLYQDEKSKDFTIIFPDETTIQVHKLILIARSNLFRGMFLSVVDNSNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4F0</accession>
    <name>A0A9Q0R4F0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4F0"/>
    <dbReference type="OMA" id="MHEPEPH"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10808" checksum="32520F5503B05E3C" modified="2023-09-13" version="1">MEDDIYYSPKYYDDEFEYRHVILPKPMGRKIPKDHLLSEKEWRGIGICMSRGWIHYHYHKPEPNILLFRRPLSEEQKHLQKQLGIQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4W0</accession>
    <name>A0A9Q0R4W0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein cornichon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4W0"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="17268" checksum="79F29A448AD99C57" modified="2023-09-13" version="1">MSFLDLCSSTETIFWVINLIINLTQFILLLKPLLDLTDYRPEFQDPIKLCDNLNKWIIPEYFFQALSTILSLFSGKILLFLISISVTIFNGYQYYYFKYQYNPAELYRTQFKHRKEGLIKLLIALICLVYVVLKSSFCFFSFLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R505</accession>
    <name>A0A9Q0R505_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox protein extradenticle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R505"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="211" mass="25601" checksum="E71DFA2EB54AD846" modified="2023-09-13" version="1">MKNSGISFISEILKDIQQIHLEKNENEKEKEKEKEKVEQKSSFQKSIEKLDKAIEDYNKTTSNRLKKLKTKYKRETKNIEKSKEKWIRKLTKLIKIEDPKSFKTFFERMNLKFERLQERLDNNVIVMMERLTCNEKKRKKADKNSQQILENWFRSHINTQNGPYLTKEQKVKLAKQCKMTEEQIATWFGNRRRKFKDLVIEGKEKKPIWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R556</accession>
    <name>A0A9Q0R556_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R556"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="120" mass="14926" checksum="BD6FCFBC3C355FD9" modified="2023-09-13" version="1">MEFLEFLELKNWINFWEQFYQVCEKNFKKIKTEITQRKRNNDPLVEHMGTEFYFFQKKHLENIIQKNFENQKFRKLESIFMLQQIAINEIFQMKKNQKIQDLIINYIFSLFQTCFCRSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R592</accession>
    <name>A0A9Q0R592_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R592"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="477"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="584" mass="67948" checksum="39DA6EA04CC29A76" modified="2023-09-13" version="1">MNEILFFGFNYESKLFKNESNKITKPIQFKFENENEKQIKQIVSGNFSTIFLFKNGKAIEYLRENNSNQNPKRIQIEENIQKVTVGSRNEAILTIEGNVFAKGKDINSNNPKEFINISSLIEDTNDRTIQDIVCSYNSIYLLTSNQNAYGIGSNSLYQLGFDSKTLNETQKPILMMKNVSKIFSGNSSTHAFLLNSNQELFGCGWNEYGKIALGESRKDEIIQKLTQIQNIPKGKIIDIQCGFTHSIMLIENENENENPKRKLYSCGDWEYNGLGTNTYEFTEIKSSLFENDYILDFSVGFDYTLILTSNSKLIGFGNNSYGQLGTGDINNQSIPIQIELPKLKFNEEISNYHISCGASKSFIYYSPLSFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISTKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITNDIIEEIEIGIDYFQLNQTNPNLFDLLINKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5F3</accession>
    <name>A0A9Q0R5F3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5F3"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="50"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="406"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="626"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="733" mass="86814" checksum="9E4E9793DA43C11E" modified="2023-09-13" version="1">MRRFTISSPRPNLNQTKSNPLHPSQSHRVTFFELTKRPIEQEKYMDVNNLNNESIFHLIKDETNFIKSLIKLKENFIEKIESLQIIPKNIQSLLFENIKELYQHQKNFLQKVHSLAKDQSSTIKVCFKDFNFQIFRKYIQNFEVILYYFDDLLQKNAQFSQICKDLEKEMGEKIKLLLFSPLQEINQYYLNIHKFLSNIDPKSDIYSSYYPILQEIFKISEEPNFHPYLYLFEHQKELGNIEKQIDGLKDFELENPRRYLHRIGSFRRIMRNKNYPGKYYAFNDMMIVAKAPKSKETTKFDHLFKYQEIQLRNLVDDENIGIQNAIEIIFPETADLYICSFSTSEEKNTLWKELTIDFNVKIDETSLSAEKLQQMMQKKRILVSYPKDKDSNIDDFPIPKNTNTEKRGNIILEIIQTEEDYLSSLNIIIEYYKKPLVQKKIISSEDSTEIFKQIETIFGVNKQLLELLKKDLPKNPKEISDLKIGNIFLQVADFLKLYIDYCSSYTFSMKRLNKYTSNSKYTTFISNTRKTVPECKGLDLLDLLIKPIQRICRYPLLFQQLLKTTGQDHPDFLEIRKTYSKLNGIATQVDQRKKAAEAAKFLVDITSKIIGIKKKFPLLEPSNPRTLIKEGFMNKKSVKKIQERYFWLFNDVLIYAKAIIRNHKYSYKGRLFLAGAFVRDLSSTNHTFHMIPYGSKKSYIFYCNSEDEKLSWINEIKNQILNLESKEVLPRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5W1</accession>
    <name>A0A9Q0R5W1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rho gtpase-activating protein 68f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5W1"/>
    <dbReference type="OMA" id="CAGACHN"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="14"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="200" mass="23440" checksum="A26EE92735DA1C16" modified="2023-09-13" version="1">MEKKEIKSKQIFGISLTELEKREEETPIPRIVTNSVNYLKKKSIETTGIFRIPGNKTEMESIIKRWNKGEVIDYEKEKTLEFTVASLLKQFARDLPQSLLSNSLIQEFFKFENLNQREKIFQTKSLLENIPIYNCKILQKIMLLLRKISRHSDENLMNASALAMVFLPSFCHEQDLQSNETAQIISFFIKNSKLIFPDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6R6</accession>
    <name>A0A9Q0R6R6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6R6"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="206" mass="24202" checksum="4A2E6CDF31A850B0" modified="2023-09-13" version="1">MNISHKRKNQTNFNSLALMKKMQRTGSIRIGIKKKNKKDQKSGDFTKKIPEEISYKIFSNLSAKKLILSSSVNKNWKRITNDEFLWAKIVSNQCPRKGHLNSSWKQVFLAFSNEKNLKNMKEEVAETLRITDINESFGYFSGKECQTHNHPCIFAKGSPETNNQKFVISSKNFYEEVPISKWEDSFNLFYFLLKKRNYHPQFNDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6S9</accession>
    <name>A0A9Q0R6S9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6S9"/>
    <dbReference type="OMA" id="AYMITLN"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="196"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="790" mass="92907" checksum="E837F1F97D62D6EB" modified="2023-09-13" version="1">MNDKENKNKKSNVLQSNEPNFLLEPDFLLDAETPIPNTKDSNLNKNSNTRKENEDEKTSNQKTTRKKSLGIISSESQYQKDLEILERLKKKISTQSRKNFQLEKEIKGLDQKIALLIKNRISLDEIQLEAAENADDLKIISIKDERVREKYSNLFYLLFHEPRYLALVSRYVTPLECEKLLQLIMFTIYGNHYDQREEKLLLLLFEVALHEEFQNCTHTNTLLRANTTITKLLFTYSRRGPGQLYLKKLLSSPLQKIVDDEELNLEINPIRIYEQWINEQESTTGEMTNLKRKLVNEEAAEHPKVIEILAPRIQKLQELFNSLLDLVIEKIDMVPYGIRLICKQIRNLTQEFFPNADKYDSSALIGSFFILRFLNPAIVTPTAYHLVEGKLTPNSRRNLTLLAKILQNLSNMVDSFGKKEAYMAVLRDFMLEQRKKLCDFLERLCRVEDLEIDESLNKFLSLSSESQQIHISLNEIYFVHGLFRKYINDFISDQEDPLKKLLDTMGEEPKQLDRNLCPMIQLALENNLTSPVLQQKNNLNILYKETKEKLATIYQKLLKEFPPDKEVDTAMFIKGLQNLRKEAKVTKDAKINKKIKRILSNMKKLIREKVLSPDDNFKKLRADIETLLLQRDEYHQRILKEFELLESVKENVDLHREYLRKQLDIYREYLENVRRQAYEKQRNNMRGSLRRKNKTIKFSHAEFQKSGVLAESDIPENRQQSVFFKISNTESPGVFGFGLYYQNRPKALYETTINMENLLELQHNSELNLELEYLTLNVNLLIYTIKKNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7K0</accession>
    <name>A0A9Q0R7K0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">H/aca ribonucleoprotein complex subunit dkc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7K0"/>
    <dbReference type="OMA" id="FWISCEV"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="5">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="265"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="515" mass="59375" checksum="226F0D50F37F935A" modified="2023-09-13" version="1">MTEKKLHKKIEETEIPTEKWPLLLKNFDKLNVRSGTFHKLEEGYTPLRRPLTEYLKYGMINLDKPANPSSHEIVSWIKRILKAEKTGHSGTLDPKVTGCLIVCLNRATKLAKSQQGAGKEYVAIIRFDSALEDERKFKLTLQALTGALFQRPPLMSAVKKQLRVRTVYESKFIEFDNEKHIGVFWVSCEAGTYIRTMCEHIGFLVGTSAKMEELRRVRSGLLTENDSIVTMHDILDAQFLYENFNDESYLRRVVKPMEWILTGHKRIVVKDTTINSICYGAQLMIPGLLRFENGIEVGDEIVLMTTKGEAIGLGIALMTTAVMGSCSFGTVAKIKRVVMDRDTYPRKWGYGPKATQKKEMIQKGLLNKFGKPNEKTPLPWKQKYQEFTGKEIIQNKIEKPKLEEKPKKQKKPKIEEIEQQTEQQTEQIKQKPKKKKTKKVKNKNINQENQQENQQENQQENEQVVKKIRTKKSKKKKTQISQENPQISDSIQSNTILETPKKTKKKKTKIHSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7K1</accession>
    <name>A0A9Q0R7K1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho gtpase-activating protein 68f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7K1"/>
    <dbReference type="OrthoDB" id="5873004at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF127">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN GACJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="103" mass="11963" checksum="ADA13F44E22A4A0E" modified="2023-09-13" version="1">MSKVFGVSLENQKLNSENVPVIIVKLISRLKELDAQNIEGIFRIPGNHMQIELLKKEIDEDENYDFSIYNDVYVIASLLKQFFRELPESILTDSLFEEWNKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7U4</accession>
    <name>A0A9Q0R7U4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7U4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="184" mass="21418" checksum="3BCF0F59B80F207C" modified="2023-09-13" version="1">MIGLLLKISSFIEGEKNLESPTYPENMNAEYSTKSNSHLPNRKICAYYYPNVERHLKNSSICSIYGFFISKLSVPQIVFTHSTSETLHKHQILVLKLKFLDLHIMLFQYSILINCKGDPLPKLVIYLPLHTTDFIFQIHMMIQEFINHLQTNQLFTVKIPNPKLSNLLFQLAFQVENGIFPQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7U5</accession>
    <name>A0A9Q0R7U5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7U5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="492"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="609" mass="71305" checksum="C6D55BCD71ACC3B4" modified="2023-09-13" version="1">MNEILFFGYNQNPKLIKNKPNEITKPVQFKFENENENENENENEKQIKQISTGFFSTIFLFKNGKAIEYLNKNDSNQNPQKIQIENIQKVTVGFQNEAILTKEGNGFAKGKYINPKNPNKFINISSLIEDINDRIIQDIVSGANSIYLLTSNQNAYGIGSNQYCQLGFDSITFRKTEKLILMMKNVSKIFSGISSQSFFLLNSNQELFGSGNNFYGQLGLGKSRKETKIQKLTKIQNIPKGKIIDIQCENSFSIMLIENENENENPKRKLYSCGYWEYNGLDKYQDTNEFTEIKSSLFENDDNIIDFSCGFNHTLILTSNSKLIGFGRNLFGKLGIEDTNNQYIPIQIELPKLRFNEDVSNYHIFCGYDNSFLYYSPSFSNLEEDLIKLFERKEFCDISFKTKNGEIIESHKLILKYRLNQNENQNQIEKLKEIISNKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENEKENDKDFIIEKKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIEITKEIIDEIQIGIDYFQLNQTNPNLFDLLIKKFNNQNQNQNLKLKLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R847</accession>
    <name>A0A9Q0R847_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myb-like protein x</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R847"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="326" mass="39351" checksum="C4166CB2FB308D37" modified="2023-09-13" version="1">MKIKLKIKNQNENQNQNENENENQNENQNENQNENQNENQIENQNQNQNQNQNQNENQNENQNQNQNQNQNQNENQNENENQKENQNENQNENENENENLKENQNQNENQNQNQNQNENQNQNENENENENENLKENQNQNQNQNQNQNQNENQIENQNQNENQNENQNENQYQNQNENENQNQNQNQIENQNEMEMEMENLIDSKLLEKILDILTFILDMRDRSDIENWIDFIMAAANFYRFLLLSDLQNENFFGVWEIKHLDQTKEIFWDPLLQNIPNSIKEIETDISKSDPDEKSNLTSIQRKFQLLLTTILTLKDFIEKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R851</accession>
    <name>A0A9Q0R851_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Breast carcinoma-amplified sequence 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R851"/>
    <dbReference type="OrthoDB" id="25778at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022175">
        <property type="entry name" value="BCAS3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12490">
        <property type="entry name" value="BCAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="4">
        <location>
            <begin position="296"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="BCAS3" evidence="3">
        <location>
            <begin position="519"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="663" mass="77241" checksum="338009A654600DB8" modified="2023-09-13" version="1">MQQKDKEKTKKKQKPIAKDTQKSFLSTITPDFLTNTIHNFGSFIPKKVHKKIKEQFESEESFLKETINFVSFEFIELKNQNRTKIHFLVIGYSNGFQIWNIQNSQLKPKEIFSKRTGFEIRILKFIHPQKPIKNGELKDLSIAFVPSKIEENSIKNRIIIYSLTKNEEIKKLNFHSQIDGIITTTTGYIIIGTHNKIYILDQKTMKPKYKYPYMFMNNVSFNSIVDVGSRFIVFPTQEIPNPPFNKLLDIESNLERKLSNETTLVFPEQQENLSDSFIDAAKEIIQKLMDLIQNFESVPKFGNIIIKDFINDKILVHFKAHKHQISSLFFDNSGSLLFTSSIIGTHFRIFRIINNIIQPIQLLYTLVRGITPAKIFHASFSVDSKWVSVSTNHGTSHIFAINSTGESVNSFTHLPKYYHLISKLEKLEPKKRSKIYKSLSKVRQGIFSQTQSIENITENEEISENCFPITTHFTDNLKLFFIDLNGVLSLYSFILNPFQIGDLDNLPSYGFSLLMDEASCWDVCRRKNWKEKNSLSKLCFEIENLKGNSIENLNENLNENLNLNQNQNQNSDFLEHFILFNIETSTRFIDINERQIWNDPQFIFQKYSKNSKLKNQNENQKENQNENQKENLQNSQEISDLMNSALSSQIQFSSQNSEKEKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8B3</accession>
    <name>A0A9Q0R8B3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8B3"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="482"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="582" mass="67120" checksum="6A4E3FA74A481E4D" modified="2023-09-13" version="1">MNDCLFFGKNQYPKLIKNKPNKIIKPIQFKFKNENENENENGNENEKQIKQISSGAFSTIFLFKNGKAIEYSNEKDSKQNPSKIQIEENIQKVTVGFANVAILTIEGNVFAKGLYINPNNIKEFINISSLIEDKNDRVIEDVVCSADSIYLLTSNQNAYGIGSNNYGQLGFDSKTLKKTEKPILIMKNVSKIFSGISSLFVFLLNLNQELFGYGDNSDGQLGLGESRKKESKIQNIPKGKIIDIQCGNEYSIMLIENQNQNPKRKLYSCGDYRYNGLGKDGYTYEFTEIKSSLFENDYIREFSVGNGDTLILTSNSKLIVFGSNSHGQLGTGDTKHQLIPIQIELPKLRFNEDISNYHVLCGNENSFLYYSFSSFSNLEEDLINLFRRKEFCNISFKTKNGEIISAHKLILQAIIGQDDQIEKLQELISNKSSKESNQIFEMIYSNNSKINPKLYEEIKIDFNLFVSIEESMKELIEFENEKDFIIERKEKQYKFPKLILIMRSKLFREKFLSVTESDSNKVTDYSELSDESFQIFEYWIYSNQIKEDIQITQEIINEIKKGIGYFQLNQTYPNLLDLLIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA76</accession>
    <name>A0A9Q0RA76_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA76"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="222" mass="24549" checksum="1825ABFB2BA0944D" modified="2023-09-13" version="1">MNLNSMVDVLVHNNVIESDIVEQTMRKVDRKTFVPNLVEPYEDAPIPCGFNATISAPHIYGIFLELLKDHLQPGASVLDLGGGTGYSSALFGSIVGKKGKVVSIEHIPELSNLARSNLEKELPKLWKSNVFEILEMDGFNGYPKLAPYDVILIGAACEKIPKSLLLQLKPWGRLLSPVGPQDKSQYLTIVDKLPDGTVNITRGTKVKFTPFTSKEEQLSLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA99</accession>
    <name>A0A9Q0RA99_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA99"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="114"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="553" mass="63011" checksum="0BAE31A9CD3E9253" modified="2023-09-13" version="1">MALFFHVKLANFKGHNLLATDRNGKSDPYLKVNFDNNKHYKTKTIKKNLNPIWDDFEAEFDYDTVKPDRLAQKVLKVECYDHDRFGSDDKMGSHSIDLWSLATGPSHIDHLLREKGKPVGRLEYDVFMENYSEITIGLKNISTQILIGHYENNSADAFIEYFFSNKQENIQKSVVKRAQQNPEWDTVPEIIFQTTLKEIVSGTILISLKHSVRGGEDILLGDCEIFLKSILKPPFEKVMKYDIEEDLFSEGQKRATMKAELCYKHGVSGGAMLMENLPTPKDYPQKGMGGPPKVQKSKTAFMARPFSKMNHIGAKITLPVNQPTETTGQTQDTQDTQTQDTQTQETSNATVKPIVTPPINRPMNQTVDQSINQRLNSPLNQRGNNPLNPNFNRKFQPVLAPPQPTLQNSFVTQSPNSFQGSPLQNFANKSFNSLKQGLSQAFGGMNISQQNQYPQQKSIWKSISTTKSIWKSISTKKSIWKSISSTKPIWKSISSTKSIWKSIFSTKSIWKSIFSKSIWKSIWKSIFSKSIWKPIWKSIFSKSFTAYSYFSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAI3</accession>
    <name>A0A9Q0RAI3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAI3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040222753" evidence="1">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="123" mass="13300" checksum="5B253F445962ABD4" modified="2023-09-13" version="1">MKTTFVFLLLIFVSLVSAWDKNSFEISVAAGVVEYYSSDCVDPAYAGNLDANTCYPVDDHGVSSFGSDTSGYLYSYDSYNCTGSYTSTYVPAYGCVNLPNSGNLGSTFSVLLSLVSLLFFFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAR8</accession>
    <name>A0A9Q0RAR8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAR8"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="300"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="479" mass="55621" checksum="8EF6B2026403217B" modified="2023-09-13" version="1">MQAKFENSNKLSADLQKLFKFGKTFSDFNIVSPNPKTNLEEAIPCHKPILAFRSKYFENLFNSNPTINEEKHNEITFFVMNQLIEYIYSGTIEVTLENAIEIFIYSKKFQLEEVHSFVSKFIMDNPNLDTIVDVLNTAKKIESKEVYTFCLDYIIANFQAILETKQLFKLDNDDFEKNLDDSCIDIANEKQLFAFCIEWAQNKLKMEIGIDKLPLQDITKITDILSPFFNKIRFCDMKQEELDEVRKLEVVPEEILEHIFHFKDMINKSQKKEASALRIFLKEKGIFILEPRNKLRESLVIKKLEHERFLRDWVNEDVFFNDMKLKYSAKKNGFSAKLFHEMCDNNGKTLVLVRTTDGYVFGGFSDVGWSANLGDKKNITDPNAFIFSLVNPSNSPPIKMPVLPEKAKYAIGYWSNQGPDFGRNGNEILFNSALSGGWINLGCVYQLPDHLEYDSSEAKEFLTGSFSDWRIEEMEIYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBF3</accession>
    <name>A0A9Q0RBF3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBF3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="367" mass="43818" checksum="EE6EC497D4B51F73" modified="2023-09-13" version="1">MMEILEKFLLNKKEENQKIEKEITFSKFGSINQTKIFNGDSTFEDLEEDETNLTIQRVQNKENEQNQLSNKMLGIWDKLNQNHLENHLENHLENSFNFNEFEGLEEDETNLTIQRVQNKENEQNQLSNKMLGIWDKLNQNQNQLENQLENSFNFNEFEDLKGDETNLTIQRVQNKENEQNQLSNKMLGIWDKLNQNQLENHLENHLENSFNFNEQIENIKILQEENEGLRNKFDEQRDLLDKLTLENVQLSNENQKFNQQNKELLNLIKNLNQQNSFLNSQSNQESLIKEQNQKALENKIKELELKEKNLKLKLKKAKEFIEKNLKSKTLSQKMNKNQIEKKSPNQNKTIRPERKSRSHGSWKNDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC95</accession>
    <name>A0A9Q0RC95_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC95"/>
    <dbReference type="OMA" id="ESISIYF"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="204" mass="24467" checksum="BDC839A913DBD1BD" modified="2023-09-13" version="1">MNNKYEIKQNEESISIYFIKPTNIKNNEIEIEITKNTIKAKIKENQLIIYGKLYSEIDLEKSGWKIEKEKYIWILLSKKQKKSWPFVIESDLNGEIDSQSSKIKKSKNQKQTENENKNENQNENQNENQNQNQNENENQNKNKNQNENENQNENQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNKNKNKNQNKNENQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REH4</accession>
    <name>A0A9Q0REH4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REH4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="588" mass="68431" checksum="A7C5F41685AD13B6" modified="2023-09-13" version="1">MNEILFFGRNQSPKLIKNEPKKITKPIQFKFENENENQIKQISSSFFSTIFLFKNGKAIEYLNENDSKQNPEKIQIEENIQKVTVGDQNEAILTIEGNVFASGEDINPNNPNEFINISSLIEDTNDRVIQDIVCGADSIYLLTSNQNAYGIGSNYYGQLGLDSYSVKKTEKPILMMKNVYKIFSGNNSNSVFLLNSNQELFGCGYNYYGELGLGESRKETKIQKLTKIQNIPKGKIIDIQCGSLYSIMLIENQNKNPKRKLYSTGDSKYLELGKNQKIYEFTEIKSSLFENDDNILDFSVGFSHTLILTSKGKLIGFGNNQYGQLGNGVTNNKLILIPIQIELPKLRFNEDISNYHISCGYHKSFLYYSFHSFSNLEEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLNQNQNQNQKLQEIISNKSIKESNQIFEMIYSNRIINPKLYFEIKEIINSNEKIEEIMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQILEYWIYSNQIKEGIQITQEIIDEIKIGIDYFQLNETNPNLFDLLINKFNNQKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REJ6</accession>
    <name>A0A9Q0REJ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Intein-containing hbs1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_00552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REJ6"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030908">
        <property type="term" value="P:protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="642"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="249"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5077232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1069" mass="123935" checksum="37219B2DE65B8785" modified="2023-09-13" version="1">MSKKRIQIKQSSYDFYFSSSDSDDFYENDFSDNSKKQNDSKDFSIDFNISLNEQTKNQTKNQTKNQTVLDNSENSEKDIEIGLAQIYSIIGKDIFSENQIINALNESNFEIEKALEILQTNELSNNAIFSLQRNQESKNRNQNQNQNQNQIEIPIQNTNRNKNKNRNKNRNRNKNRNKNKNKNRNKNQNQNQNQNQNQNQNFNLNTQQIDNSNDLLRKEINTKQQMEYEIGEIYQKPNFDSNEKVKTTNILENLPKKPQFSKDNYFPKRNKNSIQRKQINKSQKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNHHKNQNHHKNQNQNQSLKSKSKPQIPQRSKAKQQEINKILKQQSIDQNQKKEQLNLVICGHVDSGKCFKKDTKILMENGLTKKIQEIQIGEKIMGLDSKPKSIIQLSRGFGNMFEISHQNYPEKYIVNEKHILTLKLKQKNKEKIIDIPILDYLRLPKKSQEKLYGFRTSIEFQNQKTEENPYLAGKKIAEIFSYKSIDFTIPFEYKVNSKENRIRFLFGFLSSQQEFDKNEKFYQVVLSEKQKQFHEDLLFLCRSLSIGVSSVYQKKQIIVLVDGSFFGKETNKVENNKDILNSKESRIQIKYIGKDYYYGFELWVNPNENPEQNSQRFLLEDFTVVHNSTITGHLLLDLGLVDSKLFRKYEKESEQKGRKSFKFAWVSDEHEDERNRGVTINVGIKRFETNTKELTLLDTPGHSDFIPNMISGTSQADVAILVVDSSPGDFEAGFSKGQTKEHAMLVRGFGIQQIIIAVNKMDVNGFSQDRFNYIKDQMSNFLTFVGFQEENIQYIPCSGFFGWNLFNNENAANFNYQTTWYQGKSLFEAIDNFKPVIRDYNKPFRLCISDVFSDQVSGLCVAGKIENGTLLTGDNLLIKPLNQYCNVKGIKKGKQNSKFAQSGENVEISLIGIDQSLLIPGQILCDPQHPIPITQVFSAQIITLEIDVPIVVGFQGILYVQSLTQPVTIKKIFGLIDKSTGETTKKNPRIIPKNSSAFVLFETNEPIPIEEFSENKQFGRFTLREHGKTIAIGIVKEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REU2</accession>
    <name>A0A9Q0REU2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REU2"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="247"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="297"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="462"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="564" mass="64695" checksum="259A0F6098AC3221" modified="2023-09-13" version="1">MLNNFAWGYNKYTQLGFTSSEEKIDIPQPFSILENETFKMIASAISSTTFINSRDELIVMGSDQKKTWKMEKQIDFIKIFSGSSIFFGLSTDNKVYCWGSDLFEKSSKAWIPDKPLEMLKDFKVIDIAAGASQYYILLDDHTLYTYGHDALPETQFISKYDLPQWKKLMEKISKIYSGNDAHFFFAITLDNKLYSAGLNSSGQLGIGDLQTSQSPKIVNFPQKIENIIDIQCGYYFSLVLVLENKIGQVYSSGSYQHNGLNLSKNAYTFQKIMDFENENITQISSGCAHSLALNDKNEIFVWGTNSYSQLGFITQNSLKPTKIQIENLNINNSLIVYAGTLNSFVYTQEITSLVQEFKDLLDNQEFCDDNITFLNGFKNIHSLVLEMRIGNQKIQVLKSILNKCTESTANQILKWIYTGSFSYEIQDILIQLGFNSQEISEKSNYSGLLKDLKHLNSQEKSKDFAIIVEGKEVKAHKVVLFARSELFKGMFLSVQDSSNRVNDYSNRNYQTIKILVDYLYSDSLPSNIKKEIIEELEDADDFYQFHSFQNFRKELDKFSIKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF93</accession>
    <name>A0A9Q0RF93_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF93"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="161"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="319"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="531"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="70996" checksum="879C0F775AECF5D9" modified="2023-09-13" version="1">MQIFVKTLTGKTITIEINSTDTIELLKERIYDKEGIPICDQRLIFAGKQLDENEKTLEQCNIKRESTLHIVLRLAPPRSSTYIKTSYGQSISVSKACPHCNSGGTINNLKAKIEKKYSIPFENQKLFCNGNLLENNKKYIDYGMGCSAKVYLDYDLKDFSFPIFVKSSNNKIFKVLLSSFEKVEKVEKVPNIQFNKLKQIIESITKIPQHKQKLFFKEVELKDDKTFSDYDISKESIIDLKNEFKDKDRIFQLYDSVNSFQQLYISPFWKTKQIREEFKNKNFSCWNKPLFFGNYLLEDEKTILDYGSEGFIDEIYSYMNIFIEISPKKRIDIDIEFNTNLTIKDIKELFQQKMKEELINQSFLLSFNNRILQDKQKLNECRIGNHSVLFYQIKINIQALNGKINELFISPYSTINEFLNELYLKGISEKNLNLNGKLITDFQKEQKLIECGIGNYSTLSYSIKINIQALNGKINILFIPLYSTINEFLNELYLKGISEKNLHFNGKLIKDFQKEQKLIECGIENDSTLSYLITIKIFQLIYEIDFTIECFDNETIQNLEQKIKKEKQIEEEFKLTFNGKELDKEKKINEYQIKHFSILRLIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFI5</accession>
    <name>A0A9Q0RFI5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFI5"/>
    <dbReference type="OMA" id="FIMQFVN"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38446" checksum="F207892FC1160B46" modified="2023-09-13" version="1">MTFLQEFSQSIPYCDNQINNNFFNKCFKQVPTGGWTVLGEVVNSWMAPRTISLTLTLLIFSLPMILLGSRKKLVHSNQTIYRFFKMKFIILNFLHRICYGLTLDVMLLSIFRQNRPCNCDLNGSGKSQFGSIYGMPSGDALTGGIVGIFLIDEKPFYPLYSRILGGLIMFLVAIERVGMGYHSVGQVTTGIVVGSLLHFYSKKTPQYITFVDSFVQIVFGFVFLRIDKSLDHFKKNDSNNLYAWLIFGIAFVVFESLNMFQNENENENNNEISETSSQEIENETFINEQNQLLLSDAKEIDTWKTGDYYWMLITVFVQWFIVAISIAWEQYAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFS7</accession>
    <name>A0A9Q0RFS7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fam172 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFS7"/>
    <dbReference type="OMA" id="FPFGKND"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="314" mass="37199" checksum="95396FDDD907485E" modified="2023-09-13" version="1">MKSKAKETFIVAHSYGGVSTISLMINKNKDFFNKVSKIAFTDSVHWFPVRGIPKNELKEYSNFLKTHAINWVTSTKKIDEILKFRDGVQCVSSGHTKHEWTTPSAQKSIWRFFFTEDFKFEFESKKSIFEDSENNENVSPKEELKEELKKEPKDEVKKESKNEELKEELKKEPKDETKEEPKDEVKEEVKEEPKDETKKETKEESKDETKKETKEEPKDEVKEEVKDESKDETKEEPKDETKEVKDEVKEEKQKEEVKDEVKEEEKEEPKDETKDEVKEEPKDESKDESKDESKDETKKEPKEAQKETKEEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG70</accession>
    <name>A0A9Q0RG70_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VLIG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG70"/>
    <dbReference type="OMA" id="QQYNHQY"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030383">
        <property type="entry name" value="G_VLIG_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51717">
        <property type="entry name" value="G_VLIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VLIG-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="715" mass="84219" checksum="466334525B04D0E4" modified="2023-09-13" version="1">MNFKNNNFSKNQNENKNNLHSNLKNTTNISNKNLQNSEKKIQEINNLENFDSSPYFSEYNSQNHSEINFEQSQFLNEIPIFKDESFEDFNDFNQEKEFSTLLFLENEKKTNLQNNLQNNLQNNLQNNLQNNLQNDLQNDLQNNLQNNLQNNLQNDLQNNLQNDLQNDLQNNLKNNLQNNLQNNLKNNLQNNLQNNLQNDLQNNLQNDLKNNLQNNLQNNLQNNLKNDLQNNLKNDLKNDLQNNLKNNLQNDLQNDLQNDLQNNLQNNLQNNLKNNLQNNLQNDLQNNLQNNLKNDLQNDLQNNLQNNLQNNLQNDLQNNLQNNLQNNLKNNLQNDLQNNLQNDLQNNLQNNLKNNLQNDLKNDLQNNLQNNLQNNLQNDLKNNLKNNLQNDLQNDLQNNLQNNLQTDLKNNLQNNLQNNLQNNLQNNLQNDLQNNLQNNLQNNLQNNLQNNLQNDLKNNLQNNLQNDLQNNLQNNLQNNLQNNLQNNLQNDLQNDLQNDLQNNLQNNLQNNLKNDLKNDLKNNIQNNLQNDLQNNLQNNLQNDLQNNLQNNLQNNLQNNLQNNLQNNLQNNLQNNLKNNLQTDLKNNLKNNLQNNLQNNLQNNLQNDLQNDLQNNLKNNLQNDLQNDLQNNLQNNLQNNLKNDLQNNLQNNLKNNLQNNLQNDLQNNLQNNLQNDLQNDLQNNLQNDLQNDLQNNLQNNLQNDLKNDLQNDLKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGA9</accession>
    <name>A0A9Q0RGA9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 1 regulatory (Inhibitor) subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGA9"/>
    <dbReference type="OMA" id="REPRMTI"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="140" mass="17056" checksum="CB251861B6D516EC" modified="2023-09-13" version="1">MENNMENNVHGILKEKNDQQKMQKNTSLRWDEENLRYNEENRTDTMIIDEPKTPYNYEQFNDSSSDSEDFDQKKNQINSNQISLDQLSETLFNSKTLNETILEDQQNKEKEFNEKRAQHYNEYFELQKYLKEQEKEENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGC7</accession>
    <name>A0A9Q0RGC7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGC7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="485"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="68850" checksum="8E43B6F75DFFF5C8" modified="2023-09-13" version="1">MNSSLEVIEYLISKGLDINAKTYFNETVLHYVCWMNSSFKIIKFLVEKGVDINALTDQNQTVLHYFCINNSTIKIIKYLISKGVDINALTDQNESPLHIACKNKLKKELILMQKTNQNQTALHYACQYNSSFEVIKYLIEKGIDINAKTNQNETLLHLSCQNNPPIKVIKYLIEKGIDINAKTNQNQTALHFACKNNSFEVIEYLISKGIDINTKTNNNETSLHFACKYDLPLQIIKYLVEKGIDINAKTNRNETALHYVCQNNSIHIVKYLIEKGIDINAKTNKNETALHFACQYNFFQLIQCLISKGIDINAKTNRNQTALHFACLNNPSFKVIEYLISKGIDINAKTNQNETALHYVCQFNSISIIEYFISKGIDINAKTKYNETVLSLSIKNENENLIKFLLMNDIDIDSLKQNQITNQFINLFFQIYSINQDLNNLLKSNNQFSDLIIQSNDSFKFKVHKLILLTRFDNNELILQKFINNYFTIIVSEEKQIKVHKLILIIRSELFKAMFELNIQDLSNQVHDYSKKSNETIQQLIYFFYHDKFNNEEEIIKKINEEIISEEFEDLKDYYQLNQNSIIDLILKELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGX8</accession>
    <name>A0A9Q0RGX8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centromere protein t</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGX8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="224"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="329" mass="39384" checksum="0ABD4C7252B5A54E" modified="2023-09-13" version="1">MSVYKTPRSLILKTSKHPLNPNFRQISNKKIEIKNENENENENENENENENENENNLIQNVENIDFNLNTSDFSSDGEDNFNLESDSNDIQELEIINSPKKQYQLSFTNQESSNIQRFLDLHQLRIPFNFNPIQKNQFEKKENISKFINKMNFNKSQTLSFKNPLKKRFEKIQTKRKIEENLENNENQNENQNENKNQNQNQNENENENQNQNQNQNHKRQKIHSKPEFPRSLTRKIFSQFCKLRIEEDAMIQILKLTPLFFEQLSNDIHQLSNENDYISHLHFFSLMKNQRFISEEKEEEDLKDFIQKILPFELSEIIFPIARAGNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4U1</accession>
    <name>A0A9Q0L4U1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_03515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4U1"/>
    <dbReference type="OMA" id="FIVKENW"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="97"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5066182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="285" mass="34064" checksum="61D536C15F081741" modified="2023-09-13" version="1">MCDDDEDYGDCPIWFRKSIFYSPPFILAFLATATYRSILMTNTLYWDEKPLIAKITLFSYHYFLLLYFITLYKSVFTDPGNAKRAVSRFDIENYFVEEKRFCKYCQIFKPERTHHCSHCKMCILKMDHHCPWVSNCIGFYNQKYFILFLFYSLLLTITISIIVFMSFITRTEENKQDIQIKNCYGTFFDFLLALLFVAFSLPFLYTNGRRVLKNVTVIEEIKSRNEEELKKYDLGIIENMKQTLGTNYFLWFFPTYKSVEGDGFFFKQSNKISINEKNLKEIKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L557</accession>
    <name>A0A9Q0L557_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000142">
        <property type="protein sequence ID" value="KAJ5066457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L557"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="492"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69808" checksum="FA15D30512A183C8" modified="2023-09-13" version="1">MNEILFFGLNNKPKLFKNEPNKITKPIQFKFENENENENEKQIKQISSGNYSTIFLFENGKAIEYLNEYYLNDSKQNPKKIQIENIQKVTVGSQNEAILTKEGNVFAKGKDINPNNSNEFINISSLIEDTNDRIIQDIVSGYTSIYLLTSNQNVYGIGSNQYSQLGVDSKTLKKTEKPILMMKNVSKIFSGNYSNRVFLLNSNQELFGCGYNEYGKFGLRESRRKDETIDKLTKIQNIPKGKIIDIQCGYDHSIMLIENQNENQNQNPKRKLYSCGFGEYNGLGKNGNTYEFTEIKSSLFEDDDNILEISCGYNHTLILTSKPKLIGFGNNFFHQLGTGDIKNQLVPIQIELPKLRFNEEISNYHISCCAYKSFLYYSPFLSPFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNEIEKLQEIISKKSIKESNQIFEMIYLNNSKINPKLYSEIKEIINSNEKIEETMKRVYLNENEKEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKKEIQITQEIIEEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6K2</accession>
    <name>A0A9Q0L6K2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1334" mass="155499" checksum="A130627C310A4899" modified="2023-09-13" version="1">MEIEIQEAEQFLSNIFKKTISFNLNELKFSIKICKLLKRIYPEIEFSISKNNSDENFKNFFEECKKQEIIEKETNPTTDKQIISKILLKIKEITTSPNSPKKKIKIKGPKSPKKEITSKELTAIIQERLETTKTNKKKSIKQKMNEEKIFSTIESTNVTEWVLQDPELYTKSSFDSKAPMQISPFSLLQDLEHIPQEVIASLKQKFASNESSFDALLISETGTTSTSSIAITSQNICIYIQGSLHFRYKFNASRLIKVFLSPSKQNQLKIIFPNQEFVFQTRNQLEVFLIWKVILMFQTYYGNLPETHPISGDVIGLDHEVEAIALRCEAKNEAVFPVQIYISKANKESINLKLSATHFTLFSVNSPTLSLAWESSVFHCVEFKNNSLQIQIASAIQNFDFAKEKENLDKIKKQSNANIVIDCNNIGKRKLISKCISLFSESKSFPKEKQPDLPSKQFSIKMEQEQKNNQNLLPFLAEQNLRKNCFAEFNLVDGAPTIIQSNTILEPFDSPLFFYERESELFEKHQTNTLSESRFQIETCGIRQENVELVLDVKHIQFLYHKNKKLLISPYFKETRILLHSKEPLYFVLILSPIKRFLLKTKTTTERSKIYRDFTRFFNMQEDNKQNPTKIYHTLSHISTRKYSDEITKLSQSLSSLSYLRTALFNYFPDEKIKKSQIDQDLQNSSQFNIFVANSFNQIVGIGNITLYTSHFDCYSLPLFQNDPDSLFCKFFLDEDSFVNIVFPSAQTRNIFINDFSMKRRPFVDNNVLKGFAHRCTFISSKGSEEGFINLESDHYTVKTNLDSFSLIYAHSNAIEKIDKKSGKFYFSPTTYFIVEFETEAKFEIFLDDFEIKREAFISKSAGFGYETFRTFIYEKGGKLMSAKVILSRNHIAIVTDPFVAFIHMRLNLQFLVYGVKMLKIEIPEIASLILEFSQPRRRAKFIQSCRSLQNKLFDKMFLNQNLPQVFHAFFLHEKGKPSTTKIEIHSEDIIFFTQKTIIRKYIPNIKLFFDDSFPRVYRIDFTDSQKNIFFTLADNTQHEHFTSILKHHQNELHKKRKQQIEHLTIARKNLLETDFYVSLLNNDSQLIQEGILSFSDKVIEFRNIQQNIYISLDQIANITEKSNDPKSLKIDTISFSYIFSFSSPILAKSFLKTYIFVRPQNSWIVALLDENSNFLRNAKIEISKSQIILTDNDSEISFDANDSQISSRNDQPLSVKITNQDNSYIFKLYSQPNFEQFFSQLSNIYFLKKFNIQLVDEENNQNKNAFLKFQKEQIQIEISEKEKIAFSRKQTELITNPEIGNKVKLINNNETYVILFSSLKIAEQFQKSFNRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6Q9</accession>
    <name>A0A9Q0L6Q9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sca1 complex scaffold protein scaa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17150at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037474">
        <property type="entry name" value="ScaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516:SF1">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1356" mass="159350" checksum="41755F57817CD364" modified="2023-09-13" version="1">MAEHKTKISIKTDTTIEKVSFGFNGLFSGPVVNAKKIKISKREQTNLAKFPVYLNSRGEPFNLYFNPVSINDLKKLSNEDNQSKNFEEKKFTSFNSLDKFPDPNNFINYQEYEKAVLEWKGKIEKELGYICLPTIIGKTYYRPKEVTEPLPSESEVTQGLTEQDFDFETENYSEFDDTELFDDDDFTDSDTLENNPDSIKISKENLNAFLNENENENQNQNQNENENKNQNQNENENQNQNENENENENINQNENINQNENQIKKIKIKIKNQNQNQNQNQNQNENENENQNQNQNQNQNQNQNENQNQNQNQNQTPKKETPKKQNKITIIETSNSKIKANSENKKLILTPLQQLKLLQAFDQGQDLSKIDLDSFNFDVSKAVSQFLEWNSQLIPQEPNPHFYKTYEQFERAYYRWTQICYSMLNEIPLHSDQFQEQIGLTQPRKNQIQQEAKKKDIPCVHNNWSNAITNVLQEYSLKSPRFLRKNSSDSSPSFFSISLFNSHQKKEEIQSYFGKVLKIIQENQEKFGKNTSPICGKLHGVLKKFSPNQSGATLISNGALLNNYFSANDSKRFDSESIIEGNELDFSVPEYDLRNTIQFNNIRENSVYANKIRTQILLVRFERRNQQYYSWQNLKKYPPSYQQKINQKIEEIIQKDDFNLEDFINALISPQLVNQFEELLEKLKTKQRKKEDDENFIDEDEKLFLSVIRVEQISSILDLFDLNFDQLIHVKISRFIYEMMKTEIGVTVLNHLVSQKEVRYLYFFTYGLSIYSSIPVELFPNIEEMRWVIEKKFGKGTSFLDFLKELQILYYLRTILQILRSIDSLRIFLEKSIVEQEKVVIGFVEKKPDILTKDLLDGMRSSSSTMSAFFVFLFIQTLKCEYKGFKKIVFGKKIDLIAAIRVLGKSKYQHSQNAAARIWDFMKTAKFLKLFLRIYSENHIVSDLFSHLEVEDVYSFLTKQFEEASKIMQEKILAKKKNPKNRGKKGKRERKTDSKLDHSKSKTEAHEFHKNVMKLPSKISTLAVSFGCYIFEQFPEFPDWINKEGTVAILSPNLFWLLLSGLRYSVTHGEYTAECQGISSFALEMIKCLLLLKNVVGTPYLAKMEPRKIDKKRSLPQKNQLLVSRNDLKTLLFLIENSPQEEYGFKTNILEIFRYLMKERSVFKEAFETNFNLAYKIKDFCSDGNDINFNRNAWRTFYQFFHYHTKICQKFIKNNIISSFMESISIHSRLPCSHGLRYFGKLLQINIINSNRISKGKVSARHNYKDSIKSFEKDAKLIADHLLQRGLFVRFHILYKNSIKSDNFINFSQLYQIYNVISYAPHCSKLRNEIRKDDSYRKGIEFFQNIKKPKDSQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7T3</accession>
    <name>A0A9Q0L7T3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7T3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22677" checksum="D188B8EDDF943A3F" modified="2023-09-13" version="1">MGRSIFISKIPPTLSIAIIYELLSEYTPRQGYIRGSYGFIKVNNHEEVIKKYSKIWLHEGPITMEIATGKRKGKKNNGHKKQRKRRKRSYKKKDKKKGDTTERNSTTKATALHPDQIDKQEGGVHKHTNKQGTEEVNNTNKEPIKRKIQNMKNPLQKPLIIQGENQKTKNSIRHIANEIAETWTRETPHFKIKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L818</accession>
    <name>A0A9Q0L818_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L818"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="127"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="224" mass="27154" checksum="E55F727DD7898008" modified="2023-09-13" version="1">MIHLNSKKSKEIVEIAINFIYTGFPNFDNLIQKLNNLINYKFRTVSVHNEVVNKLHLNEIFYKFEQIDNLRESEKEEEKRKEKEEMEINEEFFKEIGFDSNWIKSKSKRKGIIKDLSKLYEENDSKKDFTIICEEEKEIKVHKLILFLRSELFKGMFQLNIQDKSNQVHDYSEKSFETLNQFIYFLYHDKIEENKINLKIIEEFEDIKDYFQLNLNSIIDLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L891</accession>
    <name>A0A9Q0L891_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_13115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000131">
        <property type="protein sequence ID" value="KAJ5067245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L891"/>
    <dbReference type="OMA" id="MEFCDEC"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5067245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="107" mass="12195" checksum="5B01B0CC9C8160C5" modified="2023-09-13" version="1">MQFCPYCGNLLLFSGGSESGRLTLVCQTCPYRYNITQERIFPIDLKTKINKVTFVETNANQGQKTTTLQCPKCGKYEANFYELQIRSADEPMTTFCSCLHCGNKWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8D1</accession>
    <name>A0A9Q0L8D1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8D1"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="574"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1090" mass="128275" checksum="CDE5292484E88E8C" modified="2023-09-13" version="1">MKAFIQKSLSYSYLLTYGTYLKQNTKKEQLELFEHMRTELERHHIEIDTKTKKTVKYNSSQEYINLQEGKILNSHHKIKIQKTNIGMLEIANALDKNINGRVVKKGKNLIEIWDNKKSIDATFKKLERKKTLIKKGTRITRIDTQNNSTETIRGSSSQISKYFIKVASWNINGLIQKDKEKEIEATLLKHGIDVALIQETHMKKKKYFQYYNTILKPSYGTLGPQGGLNILYKKFYKPIVQEIENEDKDIQIIKIADLHLVNIYKRHDRAEDIIQQLQNVLDQYGREKTIIAGDFNMTAKTLQEKLKLGEFKRIRNKNYSRNNRNIDHLLTTAQTRSYSRTIRSELSDHNCIYNICEIKANAEFKTKAHITDSRKFQRQFVNCVQKDNFKIKETTMKKLERKWETKSRITITNKVPKAIQEIIAQLQLDPNKKYKLAQQIKKQFNNMLQSTNIDQQIEHNEWKTIKKIRGTNKTIQTQNKRLEEEFSKLIDGTNIRPDPQTLHQITQLPNPLPPPQEPQQIQIPRSEEYITIQLIQNTITKMANKAVRGFDKIENYKNTQKEVDEEYEALLNTLRLAFLNWRDNPTEAQLKYIKANNKIFIHKGGETWPAANYRPIAISNALPRIFLKIIYSNLEQEWDKIAKTQYGFRKLVDTRIATIDLLEKYNTMDSPTIMTLDITKCFDNVNHQLIRETIKKFVDHKPTQEFLIQYYAGDGYGTFQGDPLSPIIFAFTSHYLIGELEKTTAHTQMFADDVIMLLQESIDETKTKKVHELIAIYRQFGLKINESKTIITKNLNEVKYLGIHLERTTHIKNNLQKANATFEKYIYIFTNPTLSNAVKLQIYEAMILAQTYYGTEIFNITPEDIKKIDTQINSHLCQLLRINRHSPTLIYRTDAKIWSAYYTINKRKWKLQQKLRKLGHPLAENLKFTPENNKQDEIWKTRNQNQLKLLISKSIKEQIQNSESKKTKKYYNMIKDATHLERQKYLKWNSSTTLLKIRMRSNGLNGYSYRWNKNNQNKTPDCPFCDGNKENLKHALLKCPQYDQIRPQKIRNERDLKVIINKATTEQESFNTLTQFMNEIMKERAKRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8L0</accession>
    <name>A0A9Q0L8L0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8L0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="880"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1100" mass="128154" checksum="7D2969A2F4FC501F" modified="2023-09-13" version="1">MNFEFFSICQNLIKENKIELIQDFLKENQLTTKQLSKCLTISLINKRTSIEIIKLLIKSGANVNYRNRKSRRTALLTAICHSNSNEVIDFLVNSGSNLNIKDSRGKSILYHIMKYMKSDTRHLMNSVLERGVEINQEDRSTQNVLFYAIINQQPFGMIKFLIEKGANVDRKNLYGENLMHICAKYSPNIGLFQLLIDKGIEVNDTQQHFKTPLSYLLLDYQKNVEQIKFLVSKGANVGKSLFSFVMDAKYFEIAKFAFSIDSTSINEKNRLSETLLHRACLRKNNIKNIELIIQNGINVNEVDSFGSTALHVACQNRLENEVIKLLISSGVDPSIKNYFSYALEYFHKWDIYKDPELPEIMLLLFKGIGIDSRNQIRLSETAWRNFLSNMPKNNKELSSEIINILDTMIKLSYPYSQSYPFRRDTLEDLASYSYKNLEVFKFLFEKALEFKSKIKFTNIIYHVCNYPESSSLIVYILESLLKHPDINVVLNPSFLSFCHYSHGIEEFKLFLKMGVDVNYKDTYKITPLMYVCKFSPSFANISFLIESGADAFARDTNGNSILHHFCQSRSSSHKLIDIPELMKLFKSKGLSIHDKNNRNEDALICSCSNKFISDQLIRYLIEDGANLNSINFSNLSAFSLYLQNKNHCLETIKFFIEKGINQENIESGFIHWILDIYAIHDCHHLETFKFFFENNLLENKQKILFENSQVLHYFTDIGSITENELNDLFVLFINNGANIEIKTNQNENLLHSICLKHPSFIQLTKFLLSLNLDLNAVTNSKQTPLSIICEFSNSKELIPILLSKGANPNYPQNCIDLIKRNHFYFKSQFKDIEYLFWYGAEWKNPPSKGSIHMKINQLFLKTYKSYQEDFLNLFKRQELTDYKIQCKDGFILIHKLILTSRLYLENESEQEILQKFLNFAFQASKTEMEIIVEFLYSGIIEMSNYENDFKFLEKFAQNLGFPKNWIIQKSGKIGLIHDLEKLYQDEKSKDFTIIFQDETTIKVHKLILIARSNLFRGMFLSVVDNSNQVHDYSEIPSKTMKNLIGFLYLDSCSSFENSEIEYFQKAKDYFQLNENCSLDLFFSQPSLANQYFNDEYLNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L910</accession>
    <name>A0A9Q0L910_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="46"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="39"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="41"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
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    <sequence length="2191" mass="256251" checksum="13604BF495C562FC" modified="2023-09-13" version="1">MKYSRLFLKYKYPKEIIELLISKDSDINSKNNENEIPLHIALRNEYPKEIIELLISKCSDINSKNIENVLSLNIALKNKYPNEIIELLISKGSDINSKNDENEIPLNFALKNKYPKEIIELLIEKGSDINSKNNENEIPLHIALRNKYSKEIIELLISKGSDINSKNNQNEIPLHIALRNKYPKEIIELLISKGSDINSKNNENEIPLHIALKYQNSKEIIELLIEKGSDINSKNDENEIPLHIALKNKNPNEIIELLISKGSNINSKNNQNEIPLHIALRNKYPNEIIELLISKGSDINSKNDQNQIPLHIALRNEYPKEIIELLISKGSDINSKNDENEIPLHIALRNKYPKEIIELLISKGSDINSKNNENEIPLHIALRNKYPKEIIELLISKGSDINSKNNQNVLSLHIALKNKYPQEIIELLISKESDINSKTQFNHIPLYIALENQYPKEIIELLISKGSDINSKNNQKETPLHIALRNKYPKEIIELLISKDSDINLKTKDHHQALFHTMLQEYKFGNEFIKLLISKGSDINSKNKEKEIPLHIALRNKYSKEIIELLIEKGSDINLKNNQNEIPLHIALINQNPNEIIELLISKGSNLNSKNNENEIPLHIALKYQYAKEIIESLISKGSDINSKNNENETPLHIALKYQNPKEIIELLISKGSNINSKNNRNEIPLHIALKYKNSKEIIELLISKGSDINSKTKWNEIPLHVALRKKYPKEIIELLIEKGSDINSKNKWNEIPLHIALINKNSKEIIELLIEKGSDINSKNNQNETPLHYAFKNKNSNEIIELLISKGSDINSKNKWNEIPLHVALRNKYSKEIIELLISKDSNINSKNNENETPLHFALKYQNPNEIIELLISKGSNINSKNYWNEIPLHYALKNQYTKEIKIMLLRDLNIFELKQNKIYQEMIDLFPKIYSFNDDLNNFLKSNDFTDIEIKSNDGFKFQVNKQILLIRFDNNQTILTRFINICRRKSKEIIQFALNFLYTGFIDFDNIIEKFNNQFIQKESENNPNFQFLFSNEIEFKKEKKEQELILNEIENEKKQFQKGLIYDLFEQTGFDLKWIKEKEGIKGILKDFHKFYQQEETKDFTIICEEKEIKVHKLILIIRSYLFKGMFLSVNDSSNQVHDYSGKSFETIQQLIYFLYYDKIDETKLSKENIEEYNKMSFNNPIVLNYKLKQVYESILKKDLKFFDLIPDLQTTEQFEKENEPFLNYSFKNESTNEIIKKLIEKQTNLNWIDKNRNNSLHSALINKYPNEIIELLISKGSNINSKNNEKEIPLHISLENKYPNEIIELLIEKGSDINSKTKWNEIPLHIALRNEYPKEIIELLIEKGSNINSKNNENEIPLHFALENKYPKEIIELLISKSSDINSKTKWNEIPLHSALINKYTKEIIELLISKGSDINSKNDWNEIPLHIALRYNNPKEIIELLISKGSDINLKNYQNEIPLHIALKNKNPKEIIELLIEKGSNINSKNNRNEISLHFALESKYPKEIIELLIDKGSDINLKNNIFETPLHFALRYKNSKEIIELLISKGSNINSKFNWNQSILYYTLKNHYPKEIIELLISKGSDINSKNYQNEISLHFALRNKNTKEIIELLIEKGSDINSKNNRNEIPLYIALENQYPKEIIELLIEKGSDINSKNNIFETPLHIALRFKNPKEIIELLISEGSDINSKNNQNEIPLHIALKNNNPKEIIELLIEKGSDINSKNNENEIPLHFALRNKYTKEIIELLISKDSDINLKNNDNEIPLHFALRYNNPKEIIELLISKGSNINSKNNRNEIPLHFALKNQYSKEIIELLISKGSNINSKNNLNEISLHIALKYQNTKEIIELLISKGSDINSKNDWNEIPLHIALKNHYTNEIKIMLLRDLNIFELKQNEIYQEMIDLFPKIYSFNDDLNNFLKSNDFTDIEIKSNDGFKFQVNKQILLIRFDNNKTILTRFINICRRKSKEIIQFALNFLYTGFIDFDKFIEKFNNQFIQKESENNPNFQFLFSNEIEFKKEKKEQELILNEIENENEIFEKGLIYDLFEQTGFDLKWIKEKEGIKGILKDFHKFYQQEETKDFTIICEEKEIKVHKLILIIRSYLFKGMFLLNVNDSSNQVHDYSGKSFETIQQLIYFLYYDKIDETKLSKENIEEYVDLKDFYQLNLKSILGSYLLDFYSKSFSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L969</accession>
    <name>A0A9Q0L969_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Breast carcinoma-amplified sequence 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L998</accession>
    <name>A0A9Q0L998_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L998"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="103" mass="11941" checksum="0906D267C676230A" modified="2023-09-13" version="1">MSELVGSIIDIVQGKTVKEPILQIIGIDSFVVHNLKIIQKSKYIFGKPKNLIIFLERHSSKSNIFTIYIPHVLLRYDEENPGFDDIYNNDYKLKRRSENISSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9X7</accession>
    <name>A0A9Q0L9X7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polycystin cation channel PKD1/PKD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9X7"/>
    <dbReference type="OMA" id="VISDCIG"/>
    <dbReference type="OrthoDB" id="263481at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="7">
        <location>
            <begin position="344"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="570" mass="66147" checksum="B9791DA72C7FD0AA" modified="2023-09-13" version="1">MQNEQIYWKFLCFRISKIPLEESPYISPWRQWKKYKRIPFKFILHIFITILITYQVILITKYQIPYLKQTQVFLSGAFLPDSESYLPAMDGFIHKEIFTNQDFIDTLKSVTQTYYGFSNDSIGLFDYNINEDNQIEAPIFTIEEFTKTSFDEIKIDPQKINYETDFVSYPLTLKQPCGPFTNLSNDEVQNLFAKFRTAQISFSLLNLFVSEIVQCVQWNVLMSFSFVRRGGRLLSTIDFSVTSCGNQGIGLSDLLHTGEFFSAFFLIIFSFFSMITSIRLLSQQYTLYKNLSQKKEETKQVQRLFKSTTQFKIAFFDFWHVTALIGSVITIFAEAFYIYNQAQGLNQTQNFFALIFALASLFSWANLSGYFQWHKKFYLLILTLRKAIPNLLRFLAGTFPLFIGYAYMGTLYFGNYCEYFATIDQACVTLFAVLNGDVVRDTFNYLYRKNHGLAIFARIYMYTFTCLFIYAWLKLFITLVECAYSAVKEAQKPAHLVQRKTIKKLASSANFGISFPQSESMVTPLTTPGLSEKSKDQEETQTSLDTFSFDENVFVDTDGELSNDDDQKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA23</accession>
    <name>A0A9Q0LA23_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arsenite efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA23"/>
    <dbReference type="OMA" id="MVLMWGY"/>
    <dbReference type="OrthoDB" id="8299830at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="370" mass="42063" checksum="F0D6EF20A7009A09" modified="2023-09-13" version="1">MGGLSFIDRFLTLWIFLTIVVGLLLGRFVSAIPKFWDSLTIGSTNVPIAIGLILMMYPPLAKVKYEKIHQKLWKIRRLFVFSLVQNWFIGPFLMFFLVVGMLPDHKDYMTGLIFVGLARCIAMVIVWNDLALGDREIAAALVAFNSIFQILFYSVYAWFFTSPMLKLMKMGAVSSKVKMKDIAISVLIYLGIPFLMGIVTNLAFVKTKGEEWYKKHVIPKISPLTFIFLLFTIFVMFSLKGDKVLKIPLDILRIAIPLLCYFFLMFFISFLIAYRLGFGYQESTTLSFTAASNNFELAIATTISVFGLDSNESLSATIGPLVEVPVMLGLVHVALYFKNRLKKYQQEASPEIEKANEIDDLGWEDIDFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB89</accession>
    <name>A0A9Q0LB89_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">M0811_02259</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB89"/>
    <dbReference type="OMA" id="HIIANFF"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000084">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF19">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="298"/>
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            <begin position="1004"/>
            <end position="1025"/>
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            <end position="79"/>
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            <begin position="785"/>
            <end position="1030"/>
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</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBG7</accession>
    <name>A0A9Q0LBG7_ANAIG</name>
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        <submittedName>
            <fullName evidence="4">O-acyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">M0811_02225</name>
    </gene>
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        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">BMAN</strain>
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    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="O2_lipid_transport_reg"/>
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        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040474599" evidence="2">
        <location>
            <begin position="23"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="654"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    <sequence length="708" mass="83074" checksum="99CF96878BE5FBF1" modified="2023-09-13" version="1">MKQLFNIIILIIIVLEISVVNGQENCTTVYTKMFNFEVPDSYEAIYLATGKNIPKDAGDYELCWMLENTHHCIVDFVLDATVALLPLQWGFCFPDVCHPSEIPDALQIYLDHILPIPTTLITSTIEIHCLEDLQRDFSAGPVITIVLVVIVFILVVSAFFLAYFKFPQSKSIEGSQYFAVKSQQKNHENDSSDSAEISDNSKINKEEIINQKKDEERLEDNNWDQLDLKNKDSPKKSFLIKLLLSFNIFKNWRKMHKPYPFPEFSHFSFFRIISMFWIILGETISIQEVTGYRNIVYVISEDGPTTKWPFQFIMGAEFAADTFFVISGFLVTFYTIHKLKKKEFSFWKYYIHRFFRLFPVLFFVLIIYNNLSLHLSNGPYYHLVKDGLKNTCNKYWYSTLFFFNNFYPKDYNDECMNWCWYLANDVQFYIIAPIFSVLYIINQWIGFSIVGVFGIISLALNFYLVDHYNINFTLLDEDQYNTYRNKIYTKPYTRILPYLVGVGFAMATFSWKKLQPNRSEILEIEEQEKLVDKPKAFEKKKRITKIHYALSNIIFLVAFATMAVVQFSPYDNFKNLGNNWNNAQNAVYIGLSKLLWGLAVGLILLIFVYFHDTPSAFKKFLFFKIWVPISRLTYSVYVSHPVVMLMVIFSSRILFDYDTTPIFYNSIANVGTCYLIGFILYFLVEQPFMNLEKLIMKRFLNWGKSRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC50</accession>
    <name>A0A9Q0LC50_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC50"/>
    <dbReference type="OrthoDB" id="2376984at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="377"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="51740" checksum="BDBCF03C1B69830C" modified="2023-09-13" version="1">MIVSFWLWIVLVILLILLITKLIRSSCLITELYRQQVIGNVQQNQCFEDKPNMNDYLNTISIYGVELIQEIDSTYSSNPNPFPNSFSRFIYSFSRTKVNQILNAISITSGISGLIAFIILLLLWRSIFKLYKKRIMLLRQGKKPFPGFDTADPVKVTSYTNLQAWLGLVSFFLVWIFVFIILFIIPAIYWFISKEFLYGVFKYFLSLIIIIIVYQIIFGIIGQRIMRKYFTYKKIITNRTAFSIYDFIKFFMTIVSGATSLIKKLLGMGGGSILSILKLDDKKSFDESYAAMMLIDHQINNPILRVFSNYLINFVNQKKIMFQKIFPKGINQDLLNKEKKTQLTFIEYHPISHEPIQKEKIRKIFLFLLTLSANKNLKELRKKALKIEKRRKELKKEKEEKVQKLIEEKLKSNSEEKQQEEIIFDNQLEIPLIPRNRTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCC2</accession>
    <name>A0A9Q0LCC2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCC2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="239"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="418"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="629" mass="74571" checksum="1E2F7914F8A98E21" modified="2023-09-13" version="1">MSQQNNNNNSNQLRVYKIGVLGEGYTGKSTFIIQYIERRFIREEEYLFFYDPLRKQTEMDKERIIVQLYKNPPQEEHAILPINATIRANDGFIIMYSIANRRSFDEVPILIENVLRGKDVDSFPIFVVGNKIDLENERQVTKEEAEDFCIDKKIPFMELDCHNYEQVESVVIQLCKLMKNWDHIIETEERKKKKKWLRKLLVPKKECELPDEFTLPSIDIQQSSFQFDYDKIFQDKINTDVKFSFVDNSNNQGYSSFDAHQAILASRCFTFGKIFRGLKENKLEEVQQTCNSVNLKLIENKGEILTLSTEYFSIQSFYSMIRFLYSAIIDEEVKKSVKLSNDLLSISQTFKIDSLKNIMNKNISILDLQDKLKEKRENEKEILTQISDLENQISELLSNEIITMSNRFAMLLRKSPFSDFRIIIKEDEKARERRFFVHSPILSQRCEYFQLVLRNEMMEKKKEEILLSDISFDSFLLAIEYIYSDRFLPPNLTSAKQSGNTKQIIQANKIMLELLIICDYFQIPRLHQLCQKDLMENLHEDMFVFALNVSSQCNAQILEEFCTIQIGKNFQKFKKDPQFKNYLDQEQKDQIKKYQFPPENYIKYHKKFKVKLAKKFGLIEKEDERLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCK2</accession>
    <name>A0A9Q0LCK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCK2"/>
    <dbReference type="OMA" id="VRQGMAW"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="10"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="323" mass="35565" checksum="9B059740391D2A01" modified="2023-09-13" version="1">MKAVVVKEYGDKEKLLIEQKEIPKPVSGQILVKNLVFGINFMDLFQRKGIWKPPLPFTPGAEAAGIVEAVPEDYKEEEFKVGTRVAYFAMAAQSYAEYSLIPITSLVAIPEKISFEDACAVSVQGLTAHYLCHSSYAVKKGDTVLIMAGSGGVGGLLVQMCHMIGATVITTVSSEEKMKIAKEFGADHVINYTVSDFKEEVRKIFPNGVDAVFDGVGKAVFDKALECLRMRGNYVVFGYASGQVENFDIMRLGSLGSLNLTVCVLFHFISPPEVYKKRMTDCLNWVQEGKIKPKITVVPFEKVADAHDLVESRKSTGKVIVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCL0</accession>
    <name>A0A9Q0LCL0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCL0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="311" mass="37104" checksum="87290D0324FEFAFB" modified="2023-09-13" version="1">MNSNQNLNFENNIQKRTKFTNSSFQQNYNQNSQINLNQNYNQNSQINYNQNSNQNFNQNSQINYNQNSNQNPNQKLNQNYNQNSNNIKNLITIQNPNNNFNQNELIEGEILYLRKELFQKEKENLKLDSEITKLKTQLKNQDEIKNKVLKEEIERLQARLQFIQNDLKKKDQEIEYYKSKMSKLNNSPQNISQNISQKYSINQQNLNNNNNNSFLQKLPNQNPNSFFPEPQFLQQTKERNELSPLKLSPKNKNQNQSQNINLIQIQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNLIQNQNQNQNQNQNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD94</accession>
    <name>A0A9Q0LD94_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="4">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_10678</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + succinyl-CoA = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD94"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="752"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="858"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="940"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5070608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134218" checksum="636350E08E8C6DF9" modified="2023-09-13" version="1">MLNLNLQLKLKSKSQIIFPKNEFLRLFGNSIPKSLKLKFLEAMEKSRLLETKEEALKRRGQGVFQMSCMGHEGMIGTSFAIGKEDWIHPYYRDKPIIITRGVPLDHFFLDFFGKANGPSGGRQMPNHYNNKELHIVAGGSTVAANLLQAVGMAMHLKDFGNKQVVITGVGDASTRQGEFMESVAQAVDKQLPVIFLVEDNELGISTRTKGKTFWDFPNSIVSKDDGSKWFMGCEMYEIDGTDPEKVYESTVKAVAKAREKNQPAIILAHLVRLSSHSSSDDQRVYLSQEDIDKIAKRDPVKNYEDKLISENVISREELGKMKKEIQSLIDQAVLRAKQAPNPKEVGSPYSPLPIYLPNYETCSRPKRLPKKEGGLTMAQCISKTIEQEMERNSKITVYGEDIEDPKGEVFSVTKGLSTRFPKRVTNSPLAEATIVGTAAGRALLEGDPQVAFLQFIDFVHPALNQLWTQIGMMHWRSNGQYTTPVVLMASYGAYTPGVGAYHAATSEAQFAHNPGFNIVIPSNAADAAGLLRFALRSKRPVIYLYPKVLLHSSTDTISTPDKDCMIPFGVARIVKPGEDVTIVTYGNTVKICTQAAKIAKEQYGINAEVIDLRTIVPWDERTVLNSIKKTGKLLVVHEDAKTCGMAGEIVSEMITQGHQYLKAPPLRNTKTDDFNPFQYDLNQAILPSVESVVQNLVKLQEYKTSNLKGDLFADNLISAKVEKPKKIEEIKEEKPKQIEEIKKEKLPGEYQILHITLPQVSPSDQDSTLIKLNAKIGDHVKQGAIIAEFEASKGSFELESPYDGEIVGILAKEGDIVLVNKPVFEIHVSNTFLENIPKEKPAKPTEPEKGLKEENKQLFPVVVPRNSPSDEDATIVKFLVKPDDIVKIDQPLADCEANKGSFTITSPVNGRVRQILVNEGEIVPVEVPVIRIEVSDKSLTGEDKISEKSNEKVNQQESQSISQKEPEYQEVILSKPQLQVGALALKSQLETPTVNIQTEVNMTKIEKQRNQLKKKIEEKYHVHVTVTDIILWAVNKAMQTDHNSTFRGILDKDGKKLKVSKNVNLGFAAINQLNEDLYTPVVRNANKLNFIQFCEKVNSLSQKVRNNEIKLDDLQGATLTVTNVGFATKVKTGTPFVIPGQLGMIGVGSIMNLPRFVDGMIIPCNVLDINLVFDHRMHNGSHATRFLEDIRLYLETMDLNTLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDE4</accession>
    <name>A0A9Q0LDE4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein fem-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDE4"/>
    <dbReference type="OMA" id="CEDNEQK"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="215" mass="24634" checksum="89C3E079A023FBCC" modified="2023-09-13" version="1">MEILFNKGANFKSTNNEETLLHLVCQSQNPNLINTIKYLISKSIKINSKNKNNETPLHIACKTQNPNLLKIIKFLLRNEANIELKTKNGETPLHIICQNINQNSLKVIKYLIKKGIDINEKNNQKETPLHFACQNINGNSLEVIKYMIENGININEKNNKKETNLHFACQNINGNSLEVIKYLIEKGINIDEKNNKKETNLHFVCQNINGNSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDX8</accession>
    <name>A0A9Q0LDX8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDX8"/>
    <dbReference type="OMA" id="LMHILIE"/>
    <dbReference type="OrthoDB" id="118951at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040241490" evidence="2">
        <location>
            <begin position="23"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="217"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="639" mass="74232" checksum="C9F57351FC24C807" modified="2023-09-13" version="1">MNLNNQIIIFILITFYFSLINCDSEICKQKYMEAITNQNPEGVEMIFLATGQGIPNDLGDYDLCTILETAHHCVVSFGLNVSGIIKNFKWGFCIPKECTQDDVSDVVSLYISIFYSFATVSDQPMDVFCADTFHPNVSIGVIITLIVIAAFSFFVLFGTFLKSNQNQNQNQNQNQNQNHLKKSNWKTFWIHFFDSFALQTNWKKLIQKHPDSTLKHLNGIRVLSIFWIIYGHTFVMQLSFGYNNEAFYFGDKGQIHRLPFQFLFASEFAVDTFLFLSGFLMAHLAFERRKSFNIGLFYFHRFWRILPTLGFVLLVFIFLSPFLGNGPYFGKLIEFIHHSCGNYWYSSLFFFSNFYPKQFGQQCMSWVWYLGVDTQFYIISPIFLYSFFYSPLFGLSLVSSFIIVSIALNFWIVHHWNINYYVFGEFHEDLDDRIYSKPHTRIPPFLVGCALAMFLYLLKSKENNQINQKENDENQIQKSKSKSKSKIISEIISILILLASLTLLIAIIVIPYDNYKESGTKWSVNTSAWYIGFSKFGWGIGIAGIVFIYYYYPTLKSIVKDFLSLDIWTPLAKLTYSSYLVHPFVIAIVSYSSRILHNHSTLALLYNSTVNGILGFFFGLVVYFLIERPFMNIERFIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE14</accession>
    <name>A0A9Q0LE14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor h</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE14"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF366">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="486"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="645"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="896" mass="105048" checksum="60954F574041C135" modified="2023-09-13" version="1">MSKEPKEENKEEKQIPEEKQEEKQEEKQEEKQERTGNQINRSLSLSNRGWDAVLKRKKRSQSQLKENPFSDSNDSNDSNQSNNNLIDSTQKPNEINDSIQKNPDLNSNSDKKPQPNLLTRNMTTNFIPQNQNKSNLEENDKNFYSFLTEHNLISENMKLDRIPKTRSEVYRPHTIKSKKNQKKESKKIQKKESKKKNQKKEPKSEKKSKLRFSFTFRSKSKQKKKEKLKKEKFQNESNLNPNLNLNPNTKSNLNPNTKPEISPTKIQTPQINPVNLSDNLTGNPIKNQIITPQISEDEKTIMESIRKSQSQDVISENLKKNKKIEIPKSEWISHIMRKHPDVLSLREQLCSFTETKSFSKSHPMAYTESKYSLSHKFIMQLVMEFLFQKGYQRTISQLEEETQIPFKLKSKNEDRLKTMLLISLKSTQKIWEIEQTKQDDLSLDQDNEVVLNELLSFQDEKTNENIDSIWLEPENSDENILYVDQEKTILCAASINRLIQILTGVEKAKREFMRVFFMTYQTFMTPKELLKKLVERFHVPKIFQMDDEQFLSYKKIIQARVCQVLKFWLRNSYSDFDESLTQEFMKFINESLIQERYSSIAMKFRTMLSNYQHSHKHEDHSFEKYPEPKIPKNIFSRNLSIFDIDDEEIAKQMCLITSNHYTLIEPKELLNNSWNETSSQLKSQNVFSMIEFSKSITNWVVKTILSETENNVKLISKLIRISINLLNFSNYQDLSSILKGIKKPKISLTAPRFSYRRYRDHITKVQSACIPYLSVYLADLTLIEEGNKDLNGNLINFNKKQLICEKDIQNKILQKIQIEENIQKVTVGFRNETILTIEGNVFAKGYDINPKNPNEFINISSLIEDTNDRIIEDVVSGAYSIYLLTSNQNVYGIGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEM1</accession>
    <name>A0A9Q0LEM1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEM1"/>
    <dbReference type="OMA" id="EVEYIMK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF17">
        <property type="entry name" value="RETINITIS PIGMENTOSA 1-LIKE 1 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="191" mass="23194" checksum="48F078D45A810334" modified="2023-09-13" version="1">MYLNILMCYNLFSEFFEQELELLLNQLNQSKKLFDFEIKILKLKLNLKLIYKIEIEIEIEIEIKIEFEIEIEIDLEIKIEIEIEIEIEIEIDLEIEIDLEIEIDLEIEIDLEIEIEIEIEIDLEIEIEIEIEIEIDLEIEIDLEIEIKIEIEFEIEIEIEIEIEIEIEIEIEIDFEIEIDLEIEIDLEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEX1</accession>
    <name>A0A9Q0LEX1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEX1"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="882"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1009" mass="117199" checksum="E37D81BC2F53F3A1" modified="2023-09-13" version="1">MEFLSNCYSPYPRWCSGFKSQQIYQNDINNLPKQRVAHSSVIYKGKMYLYSGMKLFEETYNDIYALDLKTYQWELINQEGAKPEGKNGHSAVIYSNQMWIFGGSSIDEIYTNEIACFNFESKTWQQINPTGDIPSPRMLHSAYVTEDNQMIIYGGLDNDGDFLFDLYSYSFNENKWKKLSNPPSKMDSLSSFFFNNKLYIFDMNFQMCYFYDLNKNTWSNQLQIFGPKPPSVIGHSITNIGNKIVVFGGCSSESIITNGFYIFDPLALTFREIRNFQSTLQRYKHTAVEFSSETETKLIIFGGACNEFECLNDLIEFTLPTQHQIQGRSAHCSVIYKEKLWVFGGLNQDNYFNDLLSFGFQSQKWESHEVKGDIPSPRFGMGSVLRNNSLIIFGGKTKAGLSNQLFSLDLTSFEWSNLPNGGDPIPEVSFPYLFLYKDTLFIFGGSQNSLNNLTLYSYNFENQSFSSMQINSKSIPNPLLTNPRIFHDEKLYFLSQNKLYFLEMNHLENQNLVFNPIQIENLSEKFDLDAFGFDWFQEAKYNQDSFDEFEFTSPVVINDNLMVFGGSNPKTKQISDNLISINLKDQQRQIIRNSFNQPPGLIGYSANVYQNSVVIFGGNRLNDNTDCSNEIHFFQLDSPKNPIFEDFRNLLQTDKFSDIQLNITNNETTTTTNTFHLHSLIMQTRCRNWNSENQQKFIETMSSIDLKIIHLVVDNIYSGKLENSTITKLANKELISLFELAIELGLDLLVDQAEYNLTRERLSPNNCIEMLILFEKYKRENSVNIVLNYIRGNQEELFSNVDAFENLATTNPGCLTKIEEAMTRRDAYPFIEKKVTQVMAESQFISDMEKLFKSKEFCDFEIKIEIKNEQSNEQSNEQSNEQSLTIINTNNLQSIKVHKLILFARSPYYRNLLSNSDIQEYFDLTGKSYLTIYHIIHYIYTGTIETNIDSNTLQDILDCHDFFQFNSEYLKYIIQERKESELKIQFPSQSTIFQDLEQQIMNLNYEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFD8</accession>
    <name>A0A9Q0LFD8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cue domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFD8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040192">
        <property type="entry name" value="CUEDC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467">
        <property type="entry name" value="CUE DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13467:SF3">
        <property type="entry name" value="CUE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="240" mass="28424" checksum="33B5FD9E991B9732" modified="2023-09-13" version="1">MSQTISLKEALTTLKEMFPDFQEEILIQVIRKNQGRLERTITELLTLDPKNPQVKPARQVQSQPRQQMMQGVYPQGVYGVPQQYYMQPMQPQPRFRRSLLPPGFLQYDDDAGVTSRPRSKEEMKQIQKDSQLAQMLANREFLNTLQGDAEFREMLGNDIMRREKRAEKSKKEKEKKEKAKQKEKEKKEKQEAKKTVKKKTTRKPSRKERTRKSRLCQMIRRIAQKTICLRTWTKPLSKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFF6</accession>
    <name>A0A9Q0LFF6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFF6"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927:SF1">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="481"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="578" mass="69133" checksum="EC0E92F36922B5BD" modified="2023-09-13" version="1">MNSLNQNENENENENQLVFSAKLISLTKINQTNSQFENMGKVIVAITGIPDLFNYQIIFYQDKRNPISTIFLNKSFNFQSQNQNFLTFYEENNQKWILNFNNSQDSIEFSTQLAFILILLKNSDFDLDFDSEKINYFDISFGNDEKVIEGTKIRINYIGWIVYDISNPKIQTKFDTTYEKEIKFGCQIGDSTISKVWNLGLLGMQKGGQRIICSHPKFHFQYQYEYERMFKQKFSENSVIVYFVDLKELIPLNQIKNDQNEYYYDNYFSFQPTEQLMLDKNDPFQFNQFEQFNQFEQFDSKEFPLIENIQEHENFENIQKHESDEKTQNKIYDNIFETDEINNLNEEKKPKEIPQKEKEPKQIFIQQNYPKQPLMNINEILDLLIDTRRNGVDSKILINSLSFSFDSISQKIQQFLHSIQKMENQSDKSKKKSKLESKIDNITNQQTNIESQYLQIQSKMENLYKQFDIIEDESYFDSISQQETKDKMKELEQSIHNLKEENEKLKENEVQLQNFRSINDSNEISILQEKLDEKDEEILELKKKIEDISIKSNEEFELKQKEFEQKQKEFEQNKKNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFM9</accession>
    <name>A0A9Q0LFM9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFM9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="98" mass="11820" checksum="E4CF97AB2CF856C6" modified="2023-09-13" version="1">MYNQKHIFKTGPTIQYGKPVHHVVARGYFILACSILGFTFIIYSLIVKIIPEPKDPDFLFEFFHNDWYYTFLITFIVHTVFVFVYFEWLSYETFTRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFY9</accession>
    <name>A0A9Q0LFY9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Major vault protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_09562</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFY9"/>
    <dbReference type="OMA" id="PKRPNHI"/>
    <dbReference type="OrthoDB" id="6125719at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000002">
        <property type="entry name" value="Major vault protein-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041134">
        <property type="entry name" value="Vault_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF3">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17794">
        <property type="entry name" value="Vault_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17795">
        <property type="entry name" value="Vault_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17796">
        <property type="entry name" value="Vault_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51224">
        <property type="entry name" value="MVP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Major vault protein repeat" evidence="11">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="219"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="223"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="11">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="279"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="9">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="7">
        <location>
            <begin position="328"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="378"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="12">
        <location>
            <begin position="438"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein shoulder" evidence="10">
        <location>
            <begin position="500"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="641"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5072182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="818" mass="93273" checksum="5116201F7BB10414" modified="2023-09-13" version="1">MSGVLRLKADLYIHVLDENTNTVRLVQGPQTYTRKQNETIVSEPKKMILVPPRHYCVIRNPVLRKDNKIILDEFQQAKLKWGDTEIRFESTEPFPLYPGEELSGKIQELINLPVAQALRLRANRDFKEIIKKKEVPRSAGDEWYFFGPNTYYPRIEVDVIETVKSTVIKPNTALKIKARRNFVDRKGIQRRAGEVWLVREEGDYLPDVDEIIAGSVRAFVLTDKKALHLRATKSFKDYLNIDRKAGEEWLVTLDMTETYIPDVYEEVVGQVSKITLTTLQYCVILDPFDENNKQRIGHKELRKGECSFFLKPGEKLEKGIQSIYVLAWEEALLLRCIQPFRDETEKKDRIPGETWLVKGPIRFIPPNEVDVIEKRKSIPLDENEGIYVRDLETGNIRSVIGKTHMLEANEELWKKPLPQANQKLSVNRAKAIRDPTRVITYRVPHNSAVQIYNYQNKTSRVAFGPDLVMLDPDEQFTVLSLSGSVPKRPNVIRTISLSLGPDFMTDVLVVETSDHARLSLQLSYNWHFEVDPKNPNDAKKIFQIPDFIGAACKAIGANIRGVVARTKFDDFHKKSADIIRDAVFGRDDSEKPNPTYRFETNNLVITNIDIQSVEPVDKNTLASLQKSVQLAISITTQSQEADAKQDALRREAQAKARLERQEIDDQIKAEEKRKKLLELRAESAAVKSMGTAKAEAKAKAEAAMIEGRAKVKQAELKLQAAEIKTKTEIENMKSQFKLEFEQQKKMNQLKIAKTKKMADIEINKFKEIVSSIGKDTIKAISQAGPEVQRQLLSGLGIEEYFLDPEKSPLALLGLTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG16</accession>
    <name>A0A9Q0LG16_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo repeat-containing protein 4 armc4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG16"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 4 ARMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="306"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="521"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="593" mass="65977" checksum="15FE5B10E424518D" modified="2023-09-13" version="1">METQYTINCITSGILSNSHFPRVLQNHFAYLHLFASSPENQPLFRRTGVIKIIVTSIKKNLNNQVIVLSGLSALVAIARDKTNVSEICQHGGLQLVFDTMNAYSKVVDLIGICFELLVIFSMDDEIELQIGEKSGIQLILKLLQANIDNNKLLYIGLRALKNVLFSAQNRDIFSAINGIDVITTILNTKSINSEIQQLCASILPRTIPKTARVQSLTKGTSIDTILETIQKFTSDVPVLESCFASLIQMSMNDEVELEIGKKGGLQILNQAIEANIKQSNLILLGLKAFANLTCSPQNRDIFTIMGGIQTLIHILQNNSKNIDILKFSPKILSRICSSAKNQQFVLENNMIPLFLNLIKLVQSETQFLESWYIVLIQLSLNDDLELEIGKRGGLKVLKDSLEPHLMNPDLVLLGLKAFVNLVSSSQNQQVFIAIQGIQMLVKIINENSSKNDSKEICTKILRNILMNPKNHQFLIDKDVIPFIAQTAISLQSNLPALETFLSSIGQMSKNSQIAKIFGNAQIIPFILDIINNFNNESVLYLACGCLINISCVPENKKLIREQNGMASLSSLSTKFPNNERIQNVIKNAQSNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGF2</accession>
    <name>A0A9Q0LGF2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGF2"/>
    <dbReference type="OrthoDB" id="2722301at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="84"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1056" mass="124305" checksum="A5F868D33DBCEDF8" modified="2023-09-13" version="1">MEEPEICPICFQNYSQERKPMIICQDGHSICELCLKTVDGCPFCRTSFDDFKPILNRILLQLIQTIQKKPEEQIIPFIPLSELEVEPKPFAIGGTAQIFKAKWKGKDVVIKRINVVTDEKANEQFENELKLAMKLEHPSIIKMYGKTEMDNLIGLVVEFANQGDLSNKISSLTFEEQVDYSLQIIQGIKLLHSHSVIHRDLKPENILVCDNRPKITDFGISKVREHTLKVTSATVSFGFSAPELFRKENAYDTSCDIFSLSMILYEIFSKKKPFGSENPMMITVKVIQGQRPEFPQDFPKELSELIKKGWSSNPKERCTLNEFTECLDRIKAEILNQAKKSQDLLQEIELKRKVQHLEQEQEPKKLIQEKEEILKLLKPYFAKFKLSIQEHEKDQTKEMNEIDINFIFQCMKNFSANQFIQETCCFILRKFTETETKMNEINISLIFESMKNFSTNQFIQETCCFILRKFTEIETKMNEINISLIFESMKNFSTNQIIQETCCFILRKFTETGKKMNEINISLIFESMKNFSTNQFIQETCCFILRKFTETETKMNEINISLIFESMKNFSTNQIIQETCCFILRKFTETETKMNEINISLIFESMKNFSTNQIIQETCCFILRKFTETETKMNEINISLIFESMKNFSTNQIIQETCCFILRKFTETETKMNEININLIFESMKNFSTNQFIQETCCFILRKFTETETKMNEININLIFESMKNFSTNQIIQETCCFILRKFTETETKTCCFILRKFTETETKMNEINISLIFESMKNFSTNQIIQETCCFILRKFTETETKMNEINISLIFESMKNFSTNQFIQENCCFILRKFTETETKMNEINISLIFESMKNFSTNQFIQETCYFILRKFIETETKMNEINISLIFESMKNFPINQIIQETCCFILRKFIETGKRISFNLPNLNGFNLIIKAMNNFPFNRFLQLQSILIIINIGKENENKTQIETNSGIDTIISTMVNFTDKDKEIYNKGIEALGVLVLNKKEIQKLLKEKKKIIEKRDEIKLKQLKEEYRKSKPGRKVRFFINSFQNIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGT4</accession>
    <name>A0A9Q0LGT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extensin-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGT4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="568" mass="65432" checksum="B902893F9B29F645" modified="2023-09-13" version="1">MGRTGGRSHGRSHGRSHARSSGFRSHARSSGIRSSGIRSSTTRRSGIGTTRRTAFGTSSTSHRYHHSSTSSRRKRHVTSLSRRSGFTTTFSSTKKPISHSSNSNQLRLFTSTTSTTSNTSNTPNITLFSNSNSISNTNTSQVNTNPDLLEEYSRISYSYLDPTTKNIVIELKPPRILYYKIVQFRLQQQQNQQQIQPQQIFNPLTGVFETINMGVQQPQFQQQPPQYQQPPQYQQPQEQFQQPPPQYQQPPPQYQQPQEQFQFKSPQKNIQDMTQEEFLKYQEERQREIQKTREKQQIENEKQKQQEQQNMQQNQFNFETKPFGQESQPNYAFDFTNNKPTYNSIPQNNPVKPPLQPPQPQFQPPKPPLQPPQPQFQPPKPPFQPQQPQFQPQQPQFQPQQPQFQPQQPQFQPQQSNDSISQDPEIDNCLKFITTANIVVQNGSGFFTEAKKSYFNIFLVTRDSDDPTWLVRSAKYNAMKEPTWNMSVVTKISGSFSDEVLLFEMMKPNIFSKDELVGAFEIPLTRQSIGQQENLQLSLTEGQVNCTILITQAEVPQNQNQAQLCTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH06</accession>
    <name>A0A9Q0LH06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBIQUITIN-60S ribosomal protein L40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH06"/>
    <dbReference type="OrthoDB" id="10016665at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="461" mass="53646" checksum="29BE76AABD8FBDDA" modified="2023-09-13" version="1">MKIFILQVSKTEKHELEVEPKETITELKKKISDKLLLQNQEMTLIFAGRKLMDSQTIQFYNIQKGNTIHLMTRAKQEETYANPQQNYQQQNYQNPNQNYQQQNYQQQNYQQQNYQQQNYQNPNQNYQQQQQQSYQNPNPNPNQFYQQQQTYQQQNPNPNPNQNQNQNFQNQNFQFTSTNQIGQDVSNFINNVFSQVFSNNQGQTQTQTQTQFQFFGDDDDDDDDDYSQFTQFPFNSFQFQSNQPHSFTYSFNVTQPRVSVHEQRYSQVHETPRFEEYQYNSQTQNQQNQQNQQNQQNQQNNSQSFGQNGASRAIYKSGMKFPQNSTFPNSTIFGSSSKFGQLCHFGDSCVFGSSSKFGQLSKWGNLCVFGSSSKFDQGCEFKNQTTFGNSSVFAQNSIFGNNTTFGKSCKFSQNCVFGENCFFGDNCKFSQNCKIGSNSTIGKNSSYSQSCQFGQNCVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHN1</accession>
    <name>A0A9Q0LHN1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Morn repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="333"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="469"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="930"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1490" mass="174732" checksum="90EE4A5374C27C5A" modified="2023-09-13" version="1">MTSLIFEIGSPQYFEYLSQLTDSFKFSKKQKKQKNKNKNKNKNKNYFLNQLSQVFSVQKNTALANKELREKLSEIIPNDFPSEKKIKKCKISIKPEILSQIKRDFSQENEENEKMKEFEFHDESSKEDLKSLNSNNFIEREESFKDLQKKEKSDSNFQENLQFRIQSINKITEPKQDKISQVHFERDQMDSDIEKIIENQYQSFSKENREKIARNLYQFNKQIQANHEKTEITQLKGRFGTRSTSNIDQNMIKNLPVQIKKKSRRNSFFFAFRHRDKNQNLEKEKEQEKDKDKEQEQEQEKEQELQQQLIESPVQMASPQQGAINVENFQINTLEDVLKHELPRAYFIQFCKEEDIVDNISFIIQVKEFEKTFDPMEISKLAQNIIQEFVDRKSPHEIDGKEELRQKVIHKYQSSEITLELFRELADDIRQQFSFGVLPSFLNSHHYRQFKEDLELMKMDLKPVGPQTKRDQIFQKLFKSEEEYVQDIQEFIQEAVSPLASQIAKSISTRDYNEIFFNIHDILALNKEIYKEFFEKSQTWNYMSVISDVLMKYQPRIENLYIPYCNNYEMAVLTLDRCRRTSLTGNTLKGIENKINIKKKLLLPFKRLFRYWSLTRDLLKETDSSHPDYFKLSVFYQNLEDSIINLKENETTKMLLNLSCSDILLAKQDFICGTRATVLRCPESPHVVGQDAFLYLFEDSFAWCFSQRINGNPKYGVDSIEDSRYGESDSSLMSGMRRSDSFGISESNYYETQKSPQKNRKEVAFQNSIINETEENENSNISSRFKKSNSKKGHQNKRDSKEIKNEEDLVVLRDNPRKPLRKKTYSLMLSSSYLLPDDLKQDISHYLRETSFIDTTTKTNEPKEETKSKNKGKTKTKTKTKTKSKTKTKSKNQTKKKNVKTKNPKRRTPKIPKSNLPIKKRDSKKGETTQQNDPKQEQQNQYNQYNPHNPLHQKISPNLSFSHSLPQEFTPFETQEQIQKRENIQLINQYQIDIILPVELVWIRKDPVEFQLSHGSCYEICTPERTLVIQSKEMDEWVSIVLAQTAKILGIEKENIEKQSRRKATYIYSNGTKYTGDFEDAIPTGQAEILYPNGTLFTGFFVGGLKEGKGMIRYPSGDLLEGEWHQNKPNGKFVMNYSNGSHFEGYFINGKKDGYGEFKFSNGNFYCGSFKNDRISGKGTMIYFNGDEYIGYFQNNLRHGFGKFYKKIDGQVYIGNWENDLKNGVGKQIYSSKEIYEGEWKNNLRYGKGEYSLAESKYIGNWKFDKFHGFGKMIYNNLKVYEGEFENGIRSNQGILINNHIKYIGNWKNNLPNGFGILLFFLNRDSLLSFEKEFDLDSKLQNEQLSIYQKESAKLKTLLTKKIIGNFIDGIPSGEDIEYFNYGNYALKGTFINGNPQGLGSLFLLQKEGFGSIKGNWDGEELNLKDFVKMSIQTNSNSQFHFNKKKKKKNKYQFSSYGDNIAHGKQTMIRDSPSMWLFSPKEFEFFGSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHU8</accession>
    <name>A0A9Q0LHU8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bud site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHU8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="470" mass="56987" checksum="34C5A4204C922039" modified="2023-09-13" version="1">MEAQKQRNYYVFEIKKSNQNIIEILKKFGEIEKYGILSYDKSPKIWGWVKFSKIKKSFESDDSINLFVRRNPFYECKYCHKRLEPQYLIICDNCGKFYCFNCVIDLLKKYGTEYKCQCDQKLINIESIVGKENIPKLIEESKKLTEKEYEDILKKTKESEEEHQNQNQNQNQNRNRNRNRNQNQNQNQNENQNQNYNQNQNYNQNRNQYQNRNQNRNHNKNYNQNQYQKQDKNQNQNPNGCKFFYNSKINWCYNYEHWKNKAQNPNLHPVNECICFNLSNCKNDNCPFCHPNPIRKDIEKAQQNFHSYSDNLTLDKVKFRSFYRDTRTKKIFNQCREFIKTGTCSNYNCPYEHKYYKILPFKKNYPIQRERKKKFKRSTENQIQFRNQNQNQNQIQIQFQNQNQNQIQIQNPILTSSQELSKEIEKYSKQIGFNQSNENDESNENDESNEIDPSESNESNEWHSDSSQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI13</accession>
    <name>A0A9Q0LI13_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein nirf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI13"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040119505" evidence="1">
        <location>
            <begin position="21"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="690" mass="77340" checksum="55D3E481A3716510" modified="2023-09-13" version="1">MHFSFIFLVSLTCFFLFVESEIYETNSLDFTVGIKNSVATFIDEDSGFLYFLDERDTIYLWKYNLYTLEIVDYMNVGIASAKTGGIDTVNKFLYVPTYYQGALLVKINLDTMKVTDQITLNVSYSNHAVKVEVDEVNQKAYVGYDYPDTIIKVDLASFTEEDALNIESSIFRGSLLDTANGILYTSSDGSTGSDSSIQKIDLSNFTIVDSFVVSLSGPEYLQFGVIDSSNQMLYFGTHQDPFRIVKINLATFSSVGQLTSSQSGFCYGAGIDVTNGFAYFLSVNGYLEKVNLGTFSIDDSFSFNGSYTYSIGFDSTGQSGYISLDDARVIQVDLPALTEGNKSEDIVYTKPEFILIDEVNQTGYIYFESLQGIIAKIDLGSFSIIDYLIIGPEYAVYHGEIDTANGFMYLFFNSDVLSVLKLDLSTFSIAESITVSTEGSSSYITFDSDTHFIYATFANDSDSNNYLLKISCPDLAIDQSVLFSNADTFYGLFLDSGHGYIYVWIKDNDEYGSGYLLPKIELSTFTQIALGNLTGHYMSFPVLDKSHQRLYFTIIGYSFAYFNLQDMQSIGNWMNHEFNSAYGSIIDPSDTFVFFVIDYYNADTQSTEYALIQIATLYNDLIIQLPFDSKLFSDYLYYVDISTSIGYILNQGTTPITLYQVKFTNPFTSSSQQFLFSFLVLAITLILGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI24</accession>
    <name>A0A9Q0LI24_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho gtpase-activating protein 68f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_08904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI24"/>
    <dbReference type="OrthoDB" id="6020705at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="61"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="212"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="497"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="598" mass="70326" checksum="26D84C1B4FBA86D2" modified="2023-09-13" version="1">MQNPRKIPPSPPKTKPPPLSRQLSLQTTPTKFMKDKLEKATIQQTFTNKSFDDFNSVDFSTVYKESFLYKQGKKVKTWRKRFFRLFPETLEYYSDQKAHKPLGTIWLVDCVAGRTEARKKPTFLIKSPKRMWQIQASSIKERDDWVDTLTDQIIFAKNQQERRQEKKRQLQFFLHEQKKQEEAKKIDLERYKTVLKNYSSLYHLSGDSKKYLSLSDYLHKENEEFPYFLKEAIIFLANYGMNSDGLFRVPGSQPVIDSYLKKIQEGEFKSIAPDENPHSITGAIKLWIRSLDSPLIPITFPQILEFHKIINQQQKIEYVQEMLQKLPQINLRVLSHLIPFLYEVIMSEKNNVNFSTITIIFAPTLLGFFEDLSLDQDISSSKHMFIELLIKNHEQMFSKIFGNNQNNQNNQNNQNNQNKEDIQNIQNKEDNQDDQKIQNIQNKENIKNIENIKNIENIKNIQISNSESFSDDDIDNEISSSDNENENDNDADSEIPTNLRYMKAMFNSSENQEVLQFSAGEIVYIEKIVDETWFYGNVLNRPFSESGFVPYNFLEPINDSKKIQNILRIHENILELRKQVIQLQKKMTEMANSFNDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI29</accession>
    <name>A0A9Q0LI29_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar protein sorting 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI29"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="8">
        <location>
            <begin position="142"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="359" mass="42607" checksum="D1D80C25B1043733" modified="2023-09-13" version="1">MKINFYLFNEYVESQNIISIINDPTKQTWSDWFLDKVFEVPVYTSEEQNISQEFRQKLNNRIKKYYQSIKEIQEKFEENQKLKIQILSRIEDKKLDSTKIYSENQNQNQNQNQNQNQNQNQNQNHSNQENDLNMNLETMKKIIPSIFFSPFFDLSNTEIFQNIYEIDSDSKVSLKPHQKAQHFLELIENKLSSELLEKTPYIFSSINELSDLTYKVQNTLQKITFIRDLLNKIDQDIVIKSIQITKSKTQQQNMNKLTDKMKLISVVKNGVNTAQLLLNNRDFAGALEVITTTKFVIENQLNGIQLNYVKIFQKFCLNQNENQKEINDTYENLKPIILCLLNIKYLQDAFIQYNEKNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI92</accession>
    <name>A0A9Q0LI92_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase hectd3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI92"/>
    <dbReference type="OrthoDB" id="239701at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042469">
        <property type="entry name" value="HECTD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="245" mass="28997" checksum="4F3B06B38B074DA3" modified="2023-09-13" version="1">MTKNPPELLRTPKLLVKFDPIIEEIMRNSFTEYIQKDNSEIPEKINTINLVHFLLTNLLKEDQNLFTKCRTDSNAKPVVPYSNNLTKRKQSQYIFLGKLIGISIRNSIPINIPFPSLVWKLIVFEKPNFEDLKEVDHSLFLFLEKITQNSKSQFEQLIKDHESNFTIDSFGKSNRIELFPGGSMTRLKFEITKEYSNLCQNFRMNEFFPQIHLIQEGIKQIIPNFHIFHLFTWQEFKKLISRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIC5</accession>
    <name>A0A9Q0LIC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-rich receptor-like protein kinase perk5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIC5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059177">
        <property type="entry name" value="GH29D-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13290">
        <property type="entry name" value="CHB_HEX_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="GH29D-like beta-sandwich" evidence="3">
        <location>
            <begin position="738"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="859"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123969" checksum="CBEC2D4467F8F140" modified="2023-09-13" version="1">MDSLTMTCRICPKSYYCPGDNMPHLCYNADSSQIEYINIGENSSECSFRCTMQGYYNNLNQNCSRNPIGKFSEDGINLLDCQTLIDNRFSYFTSPGLTNETSCNSTFIFQSISNESAKNISLIPGDFTIEIFAQLDSQLLEKYLEYFPEDGFVFGLVGVYDLWELTLYIQNDSQPILENLNASLRLELSFKNNSLEEEEHKIFAPKLILSSEIFQFDDKWHHYAVIGNSKEFILSFYKDGNPIGKIWYNQSELADPSQLSEQDQEKLFLYFGGIRFRSESNFYYPKTSHWFYGELDELNIFNQSIEINQLGYFTTSKFIKYSCIGRENLLIQKDDSQILCVPKSAENTESITNYENLKAFDPNKWNSSLNSEIIHYTSQCPEYYDFFNDQCMLSCKGGSIRDNFNVQNCKCGYDEYKIWGFPNDQYLTLVFSLQNTSFPIEISEIQFVDSKGVYLEIEDCYEDDPFPQCRVLFDNIKKKSKLTMSSSSSYNFGFANVWIVSGVEPKRVTFKFLNQNANISNIAIYSSSSSNNSLIGFFDFYLSDILPPANSTNWGTKITTKINPIYSGITELIDRNTTSSYSNLTYCQKCSGNSSSSILPRTSVLDCICNQGFVRLNEPTHKCLIGKSGNSEPKLSLPSGLYARGTQVYGIMDDFSSDSYLQLEMSRFSSNGTILQKVEYFYSNSDFLSLEGSMNISATVKQDGYFDSQKVLYVYEVKPQVCQPETYPNASDPNLILPTKLVLFSRTINASIFYTVDGTDPTFSSKIYSPNDNLTAYQNLVVSAIATKSGEFPSEIVRIKFVDKILLSSSSSQDQQQSSNHFGFLGGSSQKESFLLITLLCAISILLFLIVVIPLIFWMKEKKKRKKELVDQIEFEQLLLENTKGGEIELNENENENENQNQNENQNEIKNLFSTDSKKTKESNIICDYCHQKDAVWRYPNPKNTRESLKFCGDCVDFFELYFDRLRLFCCDYCDENLAKTGKKELFFNQKTGLFSCDFCVGKQIADGFVDESDLFVVPVCDLCKKEEAVWFCSDCLDKKRFLCLDCECEAHICVFHSPEQITTWKNVKNEEIELSLENIQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ19</accession>
    <name>A0A9Q0LJ19_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ19"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="241" mass="27456" checksum="D90B6003ADFDDF1A" modified="2023-09-13" version="1">MNEILFFGLNETPKLFKNKPKIITKSIQFKFKNENENENENENENENENENEKQIKQISTGEYSTIFLFENGKAIEYLSENDSKQNPSKIQIEENIQKVSSGGWNKAILTKEGNVFAKGENINPKNSKEFINISSLIEDKNDRIIEDIVSGRFSIYLLTSNQNVYGIGSNYYGQLGFDSETLSKTEKPILMMKNVSKIFSGTGSIHVFLLNSNQELFGCGYNEFGQLGLGESRKEETRIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ74</accession>
    <name>A0A9Q0LJ74_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ74"/>
    <dbReference type="OMA" id="PLYSTHI"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="181"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="777" mass="91416" checksum="FFF01F3FB5564EAE" modified="2023-09-13" version="1">MNQKNNLTQSKSNLENENQTNEIQVDFLLDEQKVQEIQSNFQQNQQNRMTKSFHFSQIKTEAQYQEDVDKLQSLKNEISTLSRRNFQLEKEIKSLDQKIALLIKQKIPPKDVEEIQIEEQEAKPTFIKDTKWNENYGRFFHTLFYKPQFIASVLRQLNPIECEKVLQLVMFTIYGNHYDEKEEKLILMLFEYALNSEFSSCSHLNVLLRANTPITKLLFTYTRRGPGQLYLKNLLSSPLQEIANDDDLDLEINPVRIYENFINEKESELGEVSNLKKKITYEESLSIPEVKNSLNKRLKSIKDIFDKVFSIITSNIDLIPYGIRLICKKIATLTQEYFPQANQYDRSALIGGFFVLRFLNPAIVTPTAYHLVDGKLKPKARRNLTLLAKLLQVLSNMVDIFGKKEDYMKVLEDFMQEKKKVLVSFFEKVIQVDDLIVDQEIDNFINLSEKVVSLRITLNEIYFMHRLFDDKIDNIPSTVNKSDLEILKESLVKLGEPPKDVEKPKNFVVQLKLLNEFSESLNQNTNFTVLYNNLKQMISGLYQNMINGKTDQEIDQMNIVTELQNFRNQMKKNKNSKANHKIKRILFNMKTLVKEGIISKDNNFRQFREDVEHHLRQRDKYHEKVLGDFKTLKTVRENVMVHREYLKKQISVYQEYLDNVRSLAYNNKKKKSDSKTKIKKKAVRLSHTELTKKGVISESEVPQERQRFVFFEFSTTDLPGIFQISLFYKNKPQPLYSTHIYMESLLESQHNSQPLYEIEHVILNVNLLIHFLNKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJS2</accession>
    <name>A0A9Q0LJS2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJS2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="173" mass="19518" checksum="07742AD748670745" modified="2023-09-13" version="1">MNEIIFFGANLYPKLIKNKPNKITKPIQFKNENENEKQIKQISSGNLGTIFLFKNGKAIEYLSENDSKSKPKKIQIEENIQKVSVGYRNEAILTKEGNLFSKGEDINSKNPNKFINISSLIEDKNDRIIQDIVSGAVSIYLLTSNHNAYGIGSNQFGQLGFDSETLPKTKNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJZ6</accession>
    <name>A0A9Q0LJZ6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJZ6"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="238" mass="28097" checksum="6D91B978F0E8CBF0" modified="2023-09-13" version="1">MFLNSNKFNSLFPNFKFQKNLSYEISSNQLLINSKNLIISNENFYSIKRNNKEISVFDIQKNQEISIINSNQNKFTDMCFSNWDDQFLITSNESKIKGWKINPKNQSKPFNRSKKIYPIFDLNAHNKEITSFSFHPSCSNLFASSSFDNSFKIWDLNQQETVLDINSLENSLLNFKKNFPDFIHELYYIPSRICWLGNSEMFLITGKQNDFLSFSIYDSRKLENQPIQSFEIIESQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKI4</accession>
    <name>A0A9Q0LKI4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKI4"/>
    <dbReference type="OMA" id="PRRLHEF"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH" evidence="1">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="202" mass="23952" checksum="68427D5277D4CEBB" modified="2023-09-13" version="1">MKPENLRNLESKTQKSLLRKSQITKKWQKRQITNFDYLMELNIIAGRSYNDISQYPVFPWIISNYESEELDLKDEKNYRDLSKPMGALNEERLQEFIQRYENFQDPDNVIPPFHYGSHYSSTAIVLFYLIRVEPFTTLAINLQGGKFDHADRIFIDVVNTWKNCLTNSSDVKELIPEFFYFPEFLQNLNKFDLGKRQSGKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKL8</accession>
    <name>A0A9Q0LKL8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKL8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="285"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="458"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="571" mass="66878" checksum="A32698A09F2B4C01" modified="2023-09-13" version="1">MNEILFFGLNQYPKLFKNKPNKIKKPIQFKFENENENENENKKQIKQISTGYFSTIFLFKNGKAIEYLNENDSNQNPEKIQIEENIQKVTVDKNDRIIQDIVSGSESIYLLTSNQNAYGIGSNTDGQLGFDSKTLKKTKKPILMMKNVSKIFSGISSKHVFLLNSNQELFGCGWNYFSQLGLGESRKEERVINKLTKIQNIPKGKIIDIKSGISFSIMLIENENENENPKRKLYSCGYSKFNGLGKGENTYEFTEIKSYLFENDNDNILDFSVGNVHTLILTSNSKLIGFGYNEYGQLGTGDTIDQLIPIQIELPKLRFNEDIFNYHVSCGGLHSFLYYSPPPFSNLEEDLIKLFERKEFCNISFKTEDEEIIEAHKLILKYRLNQIENQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYFEIKEIINSNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQILEYWIYSNKIKEEIQITQEIINEIQIGIDYFQLNQTYPNLFDLLINKFNNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKU3</accession>
    <name>A0A9Q0LKU3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM144 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKU3"/>
    <dbReference type="OMA" id="EFYPLAM"/>
    <dbReference type="OrthoDB" id="426527at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010651">
        <property type="entry name" value="Sugar_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012435">
        <property type="entry name" value="TMEM144"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16119:SF17">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07857">
        <property type="entry name" value="TMEM144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="320" mass="35967" checksum="3C5C77074B29016A" modified="2023-09-13" version="1">MNNLIIGYLASCIAALFFGSNFVPINKIQPKLGDGMFFQSFMSSGIYFIGILSLFLPEKPMFVQSGLIGGALVAIALLLVPITLEFLGLGLGALFWNGSDLITGYMVGRFGLFGTEKEEVKSEFYSISGFVLAFFALILFYFIKPITQEDQKSEERIRLLQDPKIIEEKKEKQFDEYLQEQNNTKLIKKIRLMKKKTKHLIGVILAIIVGIFTGVNLIPMMIWSGDHPNAGHFDFVFSHFTGIFLSGVLWAIACISWFVSTRILGFAVGYPIVCIGPILITSLWSIFYFREIKGKKNFLIFFSSFGLFIIAVTFLVLSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKV8</accession>
    <name>A0A9Q0LKV8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear pore complex protein nup160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="56"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="6">
        <location>
            <begin position="905"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="5">
        <location>
            <begin position="1258"/>
            <end position="1516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1535" mass="179950" checksum="FD503E8D438A42A1" modified="2023-09-13" version="1">MNYCESQLFSFSKKQIPTINVINLNKKPQKHQNEKHFSFPFSGLIQLNFPLKNHILSWKVENNQLLLVHLALKHTLLNNEIMFKFDEQIIYKSISITQENQQIILFIATISGTIHRISFPFNELELNTKGNEFAQSFFHNYTLNNFQFDFSSLKNSSKISTLCCLNNLTIIIGGENGNLFIIEYSEEKDKIILGPISQIQYNSSIKRFLGGLVPNFGDSKNQPSKIIAMNPIIFTQKTNDININYSETDSLNNIQFLQFFFIATISQDSKLRIWSIQSKQCIHEESLIDSPSPNTAQFLQQNIQKYSESSIQMKIISNGTNNFDIFIHAAQGNEPEFRIYSFQFDKKNTTKLTFINKIPSLQFGNLISFEISDPPIQNEDFSKIDSQFTDSNNSQSSSQRILWGLWSDEFDSLENSLNINYSLKFHILNNSQKNPKFHAWKEVICLKNELPNSPTQKEAGDSIQSIFDYFKVIIFDQNYFSHQNLLLSFEEFLKEQSLSIPLNFQSFTKEDLKEFLDYTFQNILQDFNEKYPNFEDHQIVEFAFVFFLRLFDYCIKIWHNLNLSIALNYCPILDSVCICKNSSITILRPCLISEEISQIIEHNITPIYSDFFGNSMSRLLYGLSLIRQNIPKNFLDELQDVLFNLNDPLEYCFEKLSWVSTGLIKNPEERVEFTKFNNKMLKIWNKIPYPVTLLESFINMIDIYDGNNENGDQNNKPNLFNSPALPTSSNYSEIVYSIVAERFRQSVHSNYQICRDLLLFLFFVSQARSSLITNSIETMINIDELLNQDPEAKLGKQLIESPISFFIDNVILKCVKLLKIYFILDWCFNNHYKPSQTDKTQIQVSREEDEKKILKVYIRDFFTKHGKEQNKLMRSNFWVFVEETSKEPWDNMMLNHINLRNSELIHFLSRNKFFYSLAKLCETSKTIHNIIFDHSAFAFLGKAYIELGNYDQAFQCFIKEGFFLKKYYEMISAKRDDNNINNDLDALFHFYTNVMEQFDLVSQHKLTIKIGEIAISQFDANLEYIGNFWTRIFNQNIKLKDYYSAFNALFHIPNKTTQNDCLDLFILEVCRNGYAHILVNLPQVSILSKQIVQVLSQKAEELNLDQLFFSKEPEKQANFHYYNILFNFLTSQNQFRSAAESLLPLCLRIENMIPSAISIELLSKFKTEEIFLNVNQTKSTQISRKKFLTLLDEFEKSLILIITSLELLDESCSWICVEKSKRLKSIFDFQTTSQDQTNQQLSLPERIMINREEVEIFELKQIQNQYVFIHSLRKLFMRNSIIPPTSRFNVKNLVSQLLNYSMIETALTLLVQYNLPLDPVFQTLTTKCVLIQKDFPKISENHSKLLLQRDLISPMEIELEDSITLLETEISLKDKKTTYWKVLENYLAKYDSRNSCYNLHQIVIQTILEIDPHFGLPLWLLKSYQEKDPENLLKNLIHYNLLNEAFSVAFDMIYKIEFLLETPKIEAMPNMFNIPYLLFDNLIKISSQKIQKQIDQNDYNLSTIILQDNLRLFQSKMDSFFSIISHFSKFISKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL10</accession>
    <name>A0A9Q0LL10_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonyl and alanyl tRNA synthetase second additional domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL10"/>
    <dbReference type="OMA" id="MPVEIDF"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF2">
        <property type="entry name" value="THREONYL AND ALANYL TRNA SYNTHETASE SECOND ADDITIONAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="268" mass="30448" checksum="7ECA629E816D139B" modified="2023-09-13" version="1">MNESIKAKKLNEVKYLFEPKLFTFETKVVSFKKDEIKKGTQFYRIELEDTIFHAKGGGQPNDIGKITSLEESDPNLQAEFIVQEVIADLQQNSIYHLGTLKNEQLIFKENQKVNLQIDKDRRELNSRLHSAGHLLSSIVTEGLKLPIVGFKGNHYPKQCFVEFEGVIENLQTQRDQIISKIQNAIDEAIANKLVLHRQIVSKDKLPEVCYSVPQTVFFDPVQVVSIGDFKGNICGGTHVEHIGEIGKLVIKKINQKKSVTRISYDIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLC9</accession>
    <name>A0A9Q0LLC9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adp-ribosylation factor gtpase activating protein 3 isoform h</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLC9"/>
    <dbReference type="OMA" id="NHKNYQQ"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08959">
        <property type="entry name" value="ArfGap_ArfGap1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="489" mass="56940" checksum="B0DFC0467C089370" modified="2023-09-13" version="1">MDQDEWKIELSKLRRQNANRRCFDCGASNPTWASLGFGVYICLNCAGVHRSLGVHITLVRSTTLDSWNAQQIKRMKCGGNSNAAQFFRTHGISSQMDAKQKYNSNIAKLYKNHLDELCSLQDENQNVKQETESAESSDEDSQENIIDFEEDDQEPKNQVKNPFENPIQNKKPNNLLEDKNQSQNYNYQPHFKNFKSSKTTSSSRLTNKKKINKKKSNKKKKQQEKIDSFDSQKSWDFDFGNDKSQNYQQNHKNYQQNHKNYQQKIIHTQSQNPNLYKKQDNDNFDWDQVSDKVEKAFNAIKQGGKKFFNSLHGFANQVISSLKEDEKDDDDMFPFLNPNSKKSEENFHPKNSLNKQSQKDTKGLFDDLFDSSNSTQNEKIPSPKQTQKNQSFLDIQANSSRKNQSFLDIQANSSRKNGKSHTQKNFLDEFNFDFQNSNKDSNTKPSYNDNIYNSNYNFNDNLNQNENDNDNDNDNLNDNENENGWFVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLS6</accession>
    <name>A0A9Q0LLS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLS6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="311"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="521"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="812" mass="94888" checksum="48CEE58A6429A425" modified="2023-09-13" version="1">MSQIAKNSQKFTKSQLSKINPKINEKFEQKKIEIIQNHLNVKKQEFQKFFSYLNLLISKGKDKSTEKNENQNENENQNENQNEIEIEIENENENQNENKEALINFINTFDNKKIELNLFEKTPPDLLYLKQEMKIMNIERNILFRQLSLKQKSFIIKKICNYLSNQSIFAITPGSTLKEPKNSSIFSLIRDTFTDKPLREYDNYICEVVLFELLKSLTKEIDLIPVDFYFERLVNYDQCDKKDLLPYIKSPEIAEIWESLIKLWKNSYSQGNLDPAQISSLYFPIIFRYLNPKIKIKDVEVKENDSEIFQLKNKEGYLDITTHTRHLFFFQNERQSQNFKTKYSIKCFVVIDDKYIHFYHEEKKENKIESFLLQDISVYQNNPKIEEESNDLIQNSENMNINTNTNTNANTNININTNPSLNMDFDFFSDDLEKSFIIMENNSGFSFKLKAKNSEEKNNWISEIYERKMALFNQTGLILNYLSTLNDKNLFVNLLIANDMTLLGAIVENFSTRIYSKNFESSETLGRALVYIFHSRDRIIPFLRWMIYLEVTEKTSDKSLFRSSSLSAKVLGIYSHLIGDEFLISTISSTINTASKVKSYLELDPEKVGKDQADRNRSAAMLIANEVIGKIMISVREMPLQFFQICRAIHKTVRRIFPSSSSSAINSFIFLRFFVPAIASPEAFGIVKESEITVTIRRNLVLVSKIIQNIANQIEGMIGAQACLNNFIAQSSVRVVKLYKQFVKIPEGKKDLWSFQHKPVSQEEIDNSIEVVQNYVKSHFDDLKDVLLHFNTRKYMTPYILDFIENLINLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLT6</accession>
    <name>A0A9Q0LLT6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein prenyltransferase alpha subunit repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLT6"/>
    <dbReference type="OMA" id="WEANRID"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="401" mass="48397" checksum="D27778FC53E141D4" modified="2023-09-13" version="1">MNIKQVFLKFYQILHQEKINEWGIIDKQDFPNLNFDPFYLETKKLGIPLEIMTSIHLYATKKLIKFKTINEKSSNDKKLQKIDQITLAIMFFNPLNYTAFNWRRKLLLARKINLKKELKINKICLTKDPKRSELWIFRKWMILNFILNNPNDLDLQQFILKELNLSGYCSEIYPRNYHSWTYRNWISKHLSIPNLIHQELNQNMKNWIQSHVSDYSGMNHRQSIINWVFLQENSSLETKNAILIDEINLNHNLLIQFPEHESLWHHRKFLFLKFLNINQIQFNQFLIENQSVSKNFDKDTIAIYIEKDIFNQKEFIHLDKVIQNEIVLVDYCQNLINNSQFQNSKADLPISYLIWVSQFVVLKMKDLNLIGFDEILKLINKKMEKFPNPKIYWNSFTFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM17</accession>
    <name>A0A9Q0LM17_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM17"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="170" mass="20316" checksum="90311588076FB896" modified="2023-09-13" version="1">MFQEPQKEEFKSLVNQLKQQMEQKNYQNFQNSNSFFSSPQTNQNENDESKNEKGIYSNEKNHDLTLNQELYNYIGESHTSTQNSNEKESEKESEYESEYEYENEPQTKENQTKGDDFLTPLYTPVPKSKTKQNKTKRKKTKQNKTKQNKKKKKNKTKQKKTQKKDINDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMA4</accession>
    <name>A0A9Q0LMA4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein kinase atg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMA4"/>
    <dbReference type="OMA" id="FHIKENY"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="439"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="545" mass="63476" checksum="116FEBB2B7EF276D" modified="2023-09-13" version="1">MKNEREDLLFQNFQPTKFIGKGSYGKVYLGKILKTKENCAIKRIDLRKTRNLENKRKKLNRELEIMKKVKHENCVKLFLLNQKIIKMQKVVYLVMEYCDMGDLQKYIQSKQERISIEEAQEIFGQIVLGLKYLHQKGIVHRDLKPKNILLQKNEDSKFGYTIKLADFGLAREIPRDEMGKSLEMNSILGTILYAAPEILFEGFYTSSVDLWSLGAILYEIITKNPPFQGRNIGDFVQKYNRIANKSLPKNYLKFIPKECNDLIEGLLTVNPNKRMTREELYNHPFIFEKLDELIGKSQNLSDLEKKIIGIAKEDFKSKENDKLSFKKGEVIEIIKFYRIFCEGILKEEKGFIELKRIDLYEEIKDIFSIIESSSNSLDYQKKMIGIISNDYKSDKVSLSIGDLVKIININQVNKTCEIEIGFGIENQTEEIPLFFLCFYEKIEENNENQENNENQNSIQMEIEDNQIQIEDNQIQIEETKKTKIKKKKSLIGIAKIDSQNQNKDILSFSKGDEVEIIEINGEMGIGYLNGKEGEIFIDDFDIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMI5</accession>
    <name>A0A9Q0LMI5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molting protein mlt-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMI5"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="569"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="705"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="774"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="977"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1084" mass="123337" checksum="0372406DDE9FAB03" modified="2023-09-13" version="1">MAEKEENIKYGNEHFSSLRDFIKQVGYEDPLIFGCQWGASAKIMKYLLSKYNEDLEDDETKQKNQERRIMFGNLIQRVNIEAKTSDGSNPLHLSCQYNADPKIIELLMNTGKININRKNNRGITPLHLSCQWNAGYEAVEMLIQKGADVNIGNSYDSIALHIACEFKAKKEVVKCLINAKSKIDALNFDGQTPLNLACGNIFSDSYEIIQMLLENGSDPNIIDSKKHSILMNACQNDADPKIIDLLLQKKADIHYKTIQDETALFFACKYSKNVETLKILLEKGSKTSIWNSSLQYPIHVALRYQESPQFIQILVDSYPKALHKQDTVKNHPIHIACEYQPQNLEVLKIIIGKSRKEINKQNDNKNTPLHLLCSKKTTAEAVKLMLQHGAGVNSLNFFKETPLHTNCKMNPDPKVVEMLVKAGSKVNLRNKQGYTPLHIACEYQTNPDAIFYIVEKIQNLNITLPDSKLTPLHIACHNQVDPKTVDFLLKAGADPKIKDADGNNALHHCCMDPNQNIGVVKKILETKNNIFTKNRSGFSPFELAIKNNSSMEIIEALFNPKDHLNLTWGGMSPLHYICARKGCYNVVKILLESGQNPNQISQNKRTPLLIACANHGDTDVIQLLFDHGALCEELTRQQTLLTGLCSLQNINLDSLRLLLSKGANPNIVNISHNSPLHVLCDNPNAPLEAFELLINHKADASCFSNFKEPLHHLLMQKNPNPKVVDLLLRSGAQINRMDSNRRSFLHFAAQFCENPEITKILLDYRNDPNLCDIGNNTPLHTASFNSADCMDQVAQLLIEYGSDLNALNNSRDTPLHMFARMNPNFEVLRVFLENNADYKCKNDTDALPADYLVNYRLRNYFDSFSSLSDDLLALYENSEFTDYQINCFDGSTRLHKIFITLRIGPSFLPKMHDVFKSKLTKDVVDFVRFLYTGKTDLQKVEKITILCQEIGLDFKKLNTRKNLLNDLEKLFHDEESKDFTIIAQNEPIKVHKFILGARSDLYKGMFLLVSDDSNQVNDYSNISPLALRALIRFLYLDNLEPDLPNFVINDLYDATDYYQLNMNSSFDFWLWKVGKNEENEDKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMV2</accession>
    <name>A0A9Q0LMV2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMV2"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="345" mass="40418" checksum="D8B24BBA5D5BAF71" modified="2023-09-13" version="1">MEDEKPKNIEQENTNLNIKPIKINVGGKIFETLTTTLSKWKNSKFEEIITNQKQFPIINDGIIFFDRNPKYFEIILDYLRTSEITIPTKLENKKGLEILIKESKYYSIHSLTQLLNEKLEVFKRQTFTPKEFRKCIHHSESNIPIQPYGPNGTRYPILDTGRVERQDLTGFSFSTVIFKNFEFIDCLFGPSTYFDTNFENCKFDGSRFEQVIFTEPIFRGPKLEKCSFQNVEFVNVNFPNNVPFKHHNFKGSVFKFCKLIKSNFSKSNFDNSSFIDCKIDGCNFSGCEMNNICIPEEQFKSCNTKGAKVKNLIDISKDKTKIKEIKEWNEILSNIDKWKQHKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP20</accession>
    <name>A0A9Q0LP20_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP20"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="33094" checksum="00EAC222BED4BE9B" modified="2023-09-13" version="1">MLLTAIVIICYIFFLICSFVALYFYTSFINTFQQRYNIFTVGQTPQDRFYLVPSQSLALIQTEIMKNQMNGIENIIWIGCPIGISFIKNEKRKLMVFSIFSLSLLFLSLFVYPVPVLIIPFSVLLVIESCFVIYFYFKDKYKLELVYVISNYRVFLAGNDPKIKHGQLFYWNLSDISSMRYRQVEENIGTVSFNLFDELVEPSFSHINEPHVIISTIYYLLNLNENHQNQTDFHYPKNNNVFFNNQYLSQTLVFPVNQRQDSTTTSYETYENSELSNNDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPC7</accession>
    <name>A0A9Q0LPC7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_06489</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPC7"/>
    <dbReference type="OMA" id="KNWRPHI"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015377">
        <property type="term" value="F:chloride:monoatomic cation symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="104"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="11">
        <location>
            <begin position="582"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="11">
        <location>
            <begin position="700"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="11">
        <location>
            <begin position="858"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="851"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5076210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="962" mass="108126" checksum="6732566A03BA1B6F" modified="2023-09-13" version="1">MTDTDWVTTDINTEIELESFTNPEQQEEQTQTQTLSSQTRKKGETPTTSRLFTEAQGRYRVSELLLEQPHSEFFTGKDVIEKRDNEEPSKPKTKKALIGTVLGVYFPSMQNILGILLFLRLPWIIGHAGVGLGLLIVIMCCSIALLTGLSLSAVSTNGVLPPGGAYIMISRALGPAFGGAFGLLYFLGNALLSSLHTLGAVEAFVSITHYNFTNAYNKQIFAMIAITILTLLVYIGIKHVSRFGALFLAVVLISVLSMYLGFFIGPNSRASSEYSAANASKLKSNLDSSFQDATGSTSFPRLLSVYFPAVTGIMSGANRSGDLKDAQHSIPIGTLSAIITVTIIYITCAILFGSVTTRTVLETDKFMVRNIGWPISNIIEIGIILAAIGASLQALTVSPRILQALSKDHLLPFLKPFEKMHKEQEPRRALILTWIIGMIFVQLGEMNNVAPIITVLLLLCYGGINLTCFNLSVLKAPSFRPRWKYFHWSTALIGFILSGVMMFLISWYTTFAALVLIFAIYRYIEWKGVEKEWGDSISGLRFKQALNNLLQLDPREVHHKNWRPQILTLLKVDENGEPTHRELIQFIYQLKENRGLSIAGCVIQGKETQENIIKAESIKQTITQAINQKKVRAFSNVVISQSIESGISFLIQGSGLGALTPNTVVFGWPKNWKSDPIWSFEFVNILHLCHDLGKSVIVCKSLSRFPNNDTILSGTMDLWWFVHDGGLELILALLLKRNKVWQNCELRIFTVAEAHEDENELKSKIETLMYSLRIPAKVLVIKLEAEDFLPFMSHLNEDIHDRHELFDTIHVQKSGSLLMLDEIEQGMLHQSLSLQKLNTHLKLEDEPFVEIENEDEIEKEIEKEKAKAKAKENDKENEKEIESDTDSQFFDRHALRIEAAKRLNLYMIKYSELSEMVLVNLPCPEFEQMPTDYMEYVDVLTNGLSRALLIRGTGREIITINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPE4</accession>
    <name>A0A9Q0LPE4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA recognition motif rrm domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPE4"/>
    <dbReference type="OMA" id="DLKKSWH"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="175"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="259"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="472" mass="54394" checksum="EB3BD5BD645C4E71" modified="2023-09-13" version="1">MNTEKSNATVYVGNLPFSMTEEEIETEFGKVAKVVNVRIAQKNGRPAGYAFVEMKNMEEAKKVVDKLNGAKVNGRTIKVELTKPKQQYPQQRSVFQDYNRGFPPRMPSPQTRFPPTRKPQQLIRRRRQPIIPKEESTNSNSYQKKALKLNGKEIDGRKIEVKIALVSPPKEESKTQIHVTNLPFNMEDKEFAKIFKKFKIKECRIARLRDGRSKGFGFVEFESHEDQQKSLKLNGKEIDGRKIGVKIAFESHKKELSKTRIHVSNIPFDMEDKKFAKIFKKFKTKECRIARTRDGRSKGFGFVEFESNEDQQKALELNDKEFGGRKIEVKIAFESHKKNESDSDSDSEIDSETDSEINQKSDSDSETDSEINQKSDSEIDSETDSEINQKSDSDSDSEIDSETDSEINQKSDSDSETDSEINQKSDSETDSEIDSKPKKQPHHHHHHSHHHSHHHSHHHHHHSQSKKNSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPH4</accession>
    <name>A0A9Q0LPH4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_07023</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPH4"/>
    <dbReference type="OMA" id="QDSKIHE"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="14">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5076159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="23181" checksum="495E17FCFF1EB5FC" modified="2023-09-13" version="1">MNNSTKRKQKDVLALMKTNFEVKLENENDLSVFTVKFHGPADTPYEGGVWDVRVQLPDQYPFKSPSIGFLNRIYHPNIEFSSGAVCLDVINQAWSPMFEIKHVFEVFLPQLLLYPNPSDPLNREAANLLSSNKNQYDLIVKKFVQQYAKPKNQDSKIHENTNESNKKEEISAEVTVSDISDLSDDPDSLYDSMYGSTNRSNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQE8</accession>
    <name>A0A9Q0LQE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras di-ras and rheb family members of small gtpase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQE8"/>
    <dbReference type="OMA" id="DISDICV"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="22271" checksum="705AA32F5C5FFDD5" modified="2023-09-13" version="1">MTETYSIVIAGDGGVGKSSITLRFVNNVFVDKYNPSLENSYRKTLEVDSKIFMLEITDTAGQEEFRSIRDFQLNKSDGFILVYSLFEKSTLDEISSIRDKILLLQNLEKDDLKTKKVPIVIAGNKVDLEKDQQREVYAKETKELSKSWGIPFYETSAKENINIDILFIQCVRRIRQYKQKPVPSHSKKFCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRE2</accession>
    <name>A0A9Q0LRE2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRE2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="90"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="537" mass="63924" checksum="54450E149000BCC2" modified="2023-09-13" version="1">MKMKMKNQNENENQNENENEIKNQNENENENENENQNQNQNENENENENENEIKNENQNQIQNENENQVEIENQNEIEIEKRKVNQITPTINAMNNFPNNENIQKNGLKILSKISFENEENQNEIKQNGIETIMKSINEFPENEKIQEKGLNLLFNLSLRNEEIKKQIKEKIEKSYKLEIITKPMDKFDKNEIIQICGWKLFLVLADKNKKKANENEIIKFTEIETKLKVMEIMKNNTFFHERALSSLQNQINQNRSKYEIINEIKSKKGIEIIFDTMEKVETMKKVQIKKKENIQEKALDILVNLTTNYENQNQNQNQNKIEIRNLNGIETIMKSINEFKENEKIQEKGLNLLFNLSLRNKKIKKQIKEKIEKSYKLEIITKPMDKFDKNEIIQMCGWKLFLVLADKNTNENEIIKFTEIETKLKVMEIMKNNTFFHERALSSLQNILKNQINQNRSKYEIINEIKSKKGIEIIFDTMEKVETMEKVQIKKKENIQEKALDILVNLTTNYENQNQNQNQNQNQNQNQNQIQKSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRL0</accession>
    <name>A0A9Q0LRL0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_06487</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRL0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5076208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="784" mass="93010" checksum="46199D237D2885C9" modified="2023-09-13" version="1">MQTNQSKSKSKHKKRNKQTKNFQTQSSKIPQQNNQQQLEEEKEIQQEQKKSRKSKKQQKTHQEKNEDNQQISILDHSKEEKVYKVEMIDINKNLDCPESIKNLKFNNSTPILIRQHTQQILQQIQTEDILQSYMFKGPPGVGKSYILYHIANYCSKLKNWIVLYLPNTADLRKKKSYIVAKKIIRKLNKNYGLLLKKYFFFTYDKEIWEIENPNQEQKLKMIGICEDLLNELVVSDCENIRILIAIDQWNILFRKEQESPKHILDVFKFIPKISYGFFLAAVSASFQDPDETYDDSSFFSIQTPLGIFNEDEFKSIVEWSKTNGLLPQDLSNTEIEKFTASIPKLIGFLFQSFKNHKLYNKKDWLNDAQQLAKNFYQKLILHVVNKKKKKYGAVNFISNIYLNSPIGYLSDEWESLGLFKKNDETHEFLPICESVRKAFISVMNTNFDEYINVLAREQSANPPNWKIQLTQQIYQQNSHNLDKLEPGTFLICYEDHPAIDCVAYSTNGNLFYIQISEESYSKHSKLDSIFQKKFNNTQETILEYYSRICGIKTEPNKCQVKTEETKETKETKETKRDIQLPPNQYYIYITTNPHYYKYSNTEYSNDPVILINFENISELNPELWHLISKKENKIYIQNENQNQNQNQNQNENQNQNQNENQNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQIQKKRKKNLVLILIKKIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRL9</accession>
    <name>A0A9Q0LRL9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRL9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47571" checksum="261B6901B0640737" modified="2023-09-13" version="1">MSFSNSLIENHPNLNDELNLEDQNPSDTGEYFVIEGNSVKRINEPPIVKKVPQNYQKSFYADRGIFYPRFHEDKKKRRGIENGQNPYMIEVLYPNKEILSAAFLWSVDEDNCSSCDCGCCCSGWEKFWRTVKVDLMLRRYLDAWPFVFIWINTFIALLGGYVVPSLYFAIKSYHESCGAGIWSYIIIMNIIIPFVGPEMLYGVAIMIRHRIKKKIIGVTPFSEMAIKNRYVAFMICILISLYGWISIYIVVKKPDSCVKVAKVLLGDGISVGMFSFTFMSIFCFFFCSNESEWTTTREESVFWKSSELPMHDLPQDLWNFPEIRQHIKLFSQNQPPTEQIPIQLNQGMISPYSNSGNNQMGNYYQIQNGNQVNNQNRVNNNNQIPIDNQDPNQKKDGINNDNLLDNQKDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRV7</accession>
    <name>A0A9Q0LRV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Microtubule associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_05558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5981756at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="309"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="640"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1292"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1634"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1803"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1954"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="2247"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="2577"/>
            <end position="2775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="871"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1198"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1520"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1871"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2181"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2477"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2768"/>
            <end position="2831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2858"/>
            <end position="2880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3059"/>
            <end position="3083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="882"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1198"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1212"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1244"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1265"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1520"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1531"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1552"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1577"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1881"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2194"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2206"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2499"/>
            <end position="2513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2782"/>
            <end position="2796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2815"/>
            <end position="2824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3332" mass="376860" checksum="4E77CEA260F48F44" modified="2023-09-13" version="1">MSNQNQEEVEILSKISPELELDMGDPKWTNRRDALQLVLEVLNVPKMAKGNYDKLVEILRNVLSNDSNLVVSGICIQCIEKLALGLRNDFKQYVSGIITPLFYKFKEKKLEEVVTNTLFSMHPYCYGLNDIIESLTQAIQHRTPKIRSDTITWLGKLFGRLSKYEIIQSIKPLTELLFKSVDDTVPAVRDAASKTIGEMVTITGDKVIEPLLSEIKPPTIKKIKKNYPNQNILDQANSTPAIPTTSTQPITKEDEQEEIQESKPTKQSKKKPIKSTKQKTKKKTETNIESNENLNQSQQQNIPIINQNNEITGEEVEILSKISPELELDMGDPKWTNRRDALQLVLEVLNVPKMAKGNYDKLVEILRNVLSNDSNLVVSGICIQCIEKLALGLRNDFKQYVSGIITPLFYKFKEKKLEEVVTNTLFSMHPNCYELNDIIESLTQAIQHRTPKIRSDTITWLGKLFGRLSKYEILQSIKPITELLFKSVDDTVPAVRDAASKTIGEMVTITGDKVIEPLLSEIKPPTIKKIKKNYPNQNILDQANSTPNDSKTTSFIPTSTPTTSTQPITKEDEQEEIQESKPTKQSKKKPTKSTKAKPSRKIPKTEKYSLETNIESNENANENLNQSQQQNIPITNQNNEINGEEVEILSKISPELELDMGDPKWANRRDALQSVLEVLNVPKMAKGNYDKLVEILRNVLSNDSNLVVSGICIQCIEKLALGLRNDFKQYASGIITPLFYKFKEKKLEEVVTNTLFSMHPNCYELNDIIESLTQAIQHRTPKIRSDTITWLGKLFGRLSKYEILQSIKPLTELLFKSVDDTVPAVRDAASKTIGEMVTITGDKVIEPLLSEIKPPTIKKIKKNYPNQNILDQANSIPNDSKTTSFIPTSTLTTSTQPITKEDEKEEVQESKPTKQSKKKPTKSTKAKPSRKIPKTEKYSLETNIESNENANENLNQSQQQNIPITNQNNEINGEEVEILSKISPELELDMGDPKWTNRRDALQLVLEVLNVPKMAKGNYDKLVEILRNVLSNDSNLVVSGICIQCIEKLALGLRNDFKQYVSGIITPLFYKFKEKKLEEVVTNTLFSMHPNCYELNDIIESLTQAIQHRTPKIRSDTITWLGKLFGRLSKYEILQSIKPITELLFKSVDDTVPAVRDAASKTIGEMVTITGDKVIEPLLSEIKPPTIKKIKKNYPNQNILDQANSTPNDSKTTSFIPTSTPTTSTQPIIIEDEQEEVQESKPTKQSKKKPTKSTKQKTKKKTETNIESNENANENLNQSQQKNIPITNQNNEINGEEVEILSKISPELELDMGDPKWTNRRDALQLVLEVLNVPKMAKGNYDKLVEILRNVLSNDSNLVVSGICIQCIEKLALGLRNDFKQYVSGIITPLFYKFKEKKLEEVVTNTLFSMHPNCYELNDIIESLTQAIQHRTPKIRSDTITWLGKLFGRLSKYEILQSIKPLTELLFKSVDDTVPAVRDAASKTIGEMVTITGDKVIEPLLSEIKPPTIKKIKKNYPNQNILDQANSTPVSSKTTSFIPTSTPTTSTQPIIIEDEQEDEKDDQNETNINEDNEQKKQPPKKQTTKKTTKITKKSTAKNPKKTQTKTKPSQNKKEEKPKPTPTTTNENTGFDPLSLVDPVDVLSKIPTDLEENMKEHKWTIRRDALQSVLEVLNVQKMAKGSYDKLVELLTNTLSSDSNLVVNGICIQCIEKLALGLRNDFKPYYAPLIPLLFFKFKEKKLEEAVTNALFSMHPYCYGLNDIMEQLTEAIQHKTPKIRSDTITWLGKLFAKLKKYEIIQSIKTITELLFKAVDDTVPAVRDAASKAIGEMVTITGDKVIEPLLSEINPTTLKKIKKNYPNQSILDQANSTPVEIPVAEKKQTKSKSTKKTKGANKAKTKTKGKGKGGKTKGKTTKTNQKPKKEATKKAKSPSVDNQPIDNANIDDDFVVDDSNVPVLDSVKSKWEEMIPQSTREDLESSKWKERVSGVDECDEIFSGFDANKTTENFGIIFRGLENIFHDPNIQVMQKSLKCFQKLLYKTKRVSRAILPEFIPQVINKISDPKLKTTIFEVLTSLTEIFTTQKIFQNIYEPALSHKSPKVLTEVLNWINTALLEFGTPTLDVKGFLEFIKKCFGNTNPLVKKAALDVVHTSRLYFGESIRVVFEELSPSILKTIDATIEKASKAQVPTPTKTMRIPKESPKKQESKKPKKTSKSKTSGKSKAKPKAKPKAKPKAKAKTTKKPQKGKAEPAPQQNSQQQIDEELVNLLKSKDWKMRQKALETLQSIFKSCTEKTSFPFQTEIFELLKGRLSETNKNLVVVVIQTLEAIAVPSGSDLKPHVGTIMPIVLTNFNDKKPNMREAVRLCLNEWTKQIGFDDFLPIIPEGLSSLKLSEARQDMCEWIAASIPTVKKADLLIPIMKPIFLCAEDRLAGTRKAAEDSIREMILQIGHKKIAIQMDGLKPTTQRTINSILEKYADLKPIKKEPAKGKKPRKKKEETNQNRKKSPVKKKGKSTKTKSTTGKSKAKSTNKSKKEDNSNAQNTADSETGILKMIKNGKKKREEQIHQNRFSVEDSKKVQEFFDWIREAAKLLVEESVHELLFSANFKLFIKGIDAVQKSIQTQPKTVLETVDIFFSFSAIRLHEGNMTGSIKVLEFLVELFKYLSASTYQLTECEAGIIMPILIDKVGGKDNLRNPIKEIFSMVNEMYPHPKLFVFYLDGLKHKNAKVKAENNSLNLLVESYLWLGYDEFQKCVLDLSPAAKSTIEDKIKKAPPCHPLETTAKKGAGKNKGKSKGKNAGKKNDNSGQKMTKLKTKGKGKTEKNDDGGNGKNKTPRLFTLDMESLQLPKVEFVDVPTQVMKPTPSPIKTMHPPRLPSQLRKSGANTRTSEIYQLISQLTTYNPPEMMEALSQVTQKVFLRKDEAIVPYIKNIVLTLAAQIHFLFVSKPPETSRRSKSAKSDLSSDSQLAAKIFDTLIAIYNETHLVDTLDLSSTQHLLQESLIFLVSKQIKILDTQDSLCKQINILILKILENTHKNIMYASIIRTLRLLLSSPYSELGLSNLQSPPMFENQRDESQSNRKSQKRAKDLNQKTEFTILLLKCLFYLVRNLPRNINHLNLDSLMFEIHLFLNTHPVHINPRSKKWKYENDFSLRAIKTLLVEIINIKKSDVLNHLTKIPLDSNPVIDDFKTPTKYPKSKAQNTSDETIPDEVSTQLDQILSKVVDPQKSTQAFTDLHQFSVKNPSVDIQQKLTKFPETIRGYISRGLSLRNSEHKHRVLGLKTSDDLRKNLNQLKFLLDQKKKSQQVRQPRKFNLKEQFSIAGLRDRLDALKKRSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUB9</accession>
    <name>A0A9Q0LUB9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUB9"/>
    <dbReference type="OMA" id="AIWSEDD"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010662">
        <property type="entry name" value="RBBP9/YdeN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15394">
        <property type="entry name" value="SERINE HYDROLASE RBBP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15394:SF3">
        <property type="entry name" value="SERINE HYDROLASE RBBP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06821">
        <property type="entry name" value="Ser_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="22454" checksum="4B1AD7E19A8A9E18" modified="2023-09-13" version="1">MIDVIIVHGFGCNSTNLWYSWLKKELDSTEEFQAITPDFPNPKDPELKEWIKTLEKAIESTNEKNQLILIGHSLGGFTILRYLEKLEDEEIRKRILSIYLVASPSLTRERATSFYSPKINLQKIDQLILDLKIPFFAIWSEDDKIVPKEHIDYLSGNDGLSSLQCKIINNYGHFLEKTNQYLLDLIKENHLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVV1</accession>
    <name>A0A9Q0LVV1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVV1"/>
    <dbReference type="OrthoDB" id="10689843at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="50183" checksum="4DC5FBB1A9BA6EC4" modified="2023-09-13" version="1">MHQYSTRFSAIRIQRVKNGDSTEIIETLFQVLNEFKKEPELKNEYQNYELILQENSQLKNENFELKKQNQILKERIKYSNSTQEDEKTSPDNLKEDIHLLKQVLSHQQKFGKVIENTISKVESRINEFTESQSLTSKSEEHKTSSRNNHSPRSDKPSRDYLQFKQILDQICHNMKIDDYSLITPTFVRTISKLEDYKIFTNEMSKIVKSINSQNDSSFISLTRESSSKISNSIKNADLILSNLKKWKIELYHSQILKNFKFQIQNEIEKINILKDDPNIVNKTSLPIPIPVSIPKSIEISEIAFQKIILIIKNLIDFYISNITKQNPNQFNKISNQNQNQYENENEYEKLTQIIFHFEKKLGLKTNNNPLIAINTIYLELKRIQTQLQTFQKTLNVNESNSSFSECLTKIHNLIYFEKLYKNQIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWF2</accession>
    <name>A0A9Q0LWF2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beach domain-containing protein lvsc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurobeachin alpha-solenoid region" evidence="4">
        <location>
            <begin position="664"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4704" evidence="3">
        <location>
            <begin position="1425"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1729"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1523"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2357"/>
            <end position="2388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1733"/>
            <end position="1747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2481" mass="292453" checksum="295D9B3CDE6EA9BE" modified="2023-09-13" version="1">MSNLDIRNQKKQTFFANFLVDGEILEKLWQIYQKSPDESNFYSFGQQFIISFMKWNPEQKFNSEKEKDLNLAIEMHFAHPYEVIVAIIKAFARCLENLEKIKITQKENERIDFRNSNLKCLISLEIILILCRSPYNREQLINLEIFTILSQFLEISKDFLIIISQQERNQHMFNNLFLVQYIYSKCLEIINRFFRHNDIDEEKKKFYIGFRRYGIVRKILESLKENLNLRKKYVFTKKHYDLQNHFLDILEQLFLFDIFSTDEKIEMASLLIDFFKLPNLQLPTIGIEEENEFEAEKKINDVYQTNFFGFNEKETEFEMIEENIVSKNFIPEHWECILVDVAFKFLILLVRHLSIHTLIISDSRILGLRELILWMAYRFRINKKDSRNEQDNLNSESDRESIQEENRDIIENSGYFFLSKCFFPQERLKLVLNFINFEVNTTNSHLDNMFHNLRNFALISPKGGLKTKIQNKYRALNEPYLILQKEENFPNTLRQRIFLLLFDLFRKRDGDSAFIQEIIDYHEKFAGELQIYVILELEKWVLLNDESLQQDLQFLQRSGCWDILFSKSFITPLYDQDFQPFPTPRLLIKLFIDIIKNFQEFDYQVLLNFISKNKNNLGILRLGLQILMVVTNDSKSREWVFGRLNRDEEFIIKLVKMMQSLRLENPKKVHGVEDREGIDEHEQENQQRKIMQLSEVVEMSFEILHQYILFETEQKRILMHKDVITLLVGILSNPHLKNFVLDDLGLIIDTIDSVTEDAQFLFGKIIEVMFFLAQYTDNISVFNFRIGVVKDILNVCINKISVHRNTIQTLLVNAGAFSALMSLLSNQKMSEDITETIFAIILQLLRENEMSLVQFKKQIGYTSFLTVLQDMQNRLTPENIFAILLQMLVNNGNFDFDNNYIIQNQDVILVIFELFSQPQYSGLDPSIEKNESKMKKQRPIEFETIVEIFSGICAKSVHNTSCCCDVGLISFLLNYIAKIDNFILLDKILTFIGKLGSHRILVAELKLYTALFKSFLRKKKTYIACEMVREMKKMIKQTQEGPSNFFDFNGTQSYIKLPPVDTSSVRGITLHTWLRFESFVSPLSTGKYRPRIFSFFQNKQAGFEFFLKTPKNTHQESQIILQVYSKKAMPQTQKVQCMLEPKIWYFMAFTLSTEREGTSICFYINDKLIRKLDLTKILLGKKYIKNRVGSNSKALHPFYGQMATIYMYDVVLESERIQSVYSLGPNYKSLFYQYELRNFRMFESMKSIFDGSLTSRILMCFNSNARQEMLCYNQSPVIGSHPELETAKLHHVFTCSRTTVDSIINCLGGIQAFFSLFFELGLEKYEENMDDKDKWNYVSLDEEDEDEDEDYLNNLNNLNNSNNLNNLNNLNNSNNLNNSNNSNNSNNSNNLNNLKDSNNLKDSNENSTKPNFINIPKNNPKNIIEKHMQSIFEQLFEIIVHILRSNKTYQTEIVAIQGFSIIALFLKQIHPKHITTKIIEMIKSLSLSPSEEIFLEEFKKNLLVNFGIWFKCAPKFQSQILHHISILIELQEKQQELSRIEKEKKQDKEWQIEMDEQTAEESGVLDYEKTHRKETKIEWKINLKDLVSIVRVYDHYMSRGKTETEYIARNSKEEEKEEEQTDEQKSIEDLCQQIFGHFRIFLARQEDSFRIIVDRCMTMRTGFIVQFALETILRFLKEESLVRMQMRIVEKNPWIFDPFLRMLENSGRLSARCLCIAIMQRLERLREKVQQRKEHKKKEKSRRKSRKQNTAGELVTLEEIFPLVHEIIVSKNLYQKGILENLYGIFVFEERNIYLEVERIQHPHVLKTICAVIAQKPTEFGLNILCCVKMRVEEEPLNCAAVLSQHGWQKWLLQLIGPSVIQKTGDFDEENQLHSAINETALGIFKRMHVYCLLQPNVSFVDVFEQLLFFIDALWHKTFVVGSSIVARMISDVVVGVDRQKPLDIPRHFIDNLAYLVGLVNVYIFPRRHPDAENTEPRKDELAHLKKWKRKIAPSSTALFGMWSRKDIRTLDPILLNTEIEEIPMMFEPSFVIRLTRLLNSAHLMSPKGLPIKEKHVLFGVYKTIVVLLLLSMKFAEQSELVLILDFLFDLHTQPLSLSSPIFKPVSQFLYITFSYLFSSIYSSIESRKSSEKHKLFASATQRLMRKTYDFFLSAIKKYNDNFAFLVRNVDQSFVTTGGTEEFVATITTQRWREIIHKVFDWNFVVLSEIENNQENFRLIQGHNAAIIVQIFKSISKKKRNNLKFLRSRINRNVSLMIRHERRRLSSIQLETEKQDRIRIQRFQKFERSSRHKNPADMKFENRTRFAEHSEIGYLGIRVKLDSTEDRNRRRRKTKLVYYGGDDDNNINENLNINENNLNINENLNINENNLNQNENNLNINENNLNENNLNINENNLNINENNLNQNNLNQNNLNQNNLNQNNLNINENNLNENNLNQNNLNINENNLNINQNNLNQNNLNINENNLNINENNLNENLKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWS1</accession>
    <name>A0A9Q0LWS1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000019">
        <property type="protein sequence ID" value="KAJ5079969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWS1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="386" mass="46611" checksum="F883023EA782E383" modified="2023-09-13" version="1">MKSQKNLNSFSTSSSDSLSDSESDSENLKMRSKKEKNQNQNQDEDENQNGNDEDEDEEIKFIFQNQQNHQKFTNKNKKIFNKQQQNKFQDPSFQNIKIYTQENSLGTTFQPKKSISQKDFPINTYQNKNEYQNEYENQNEYESENESENESENENYNNQNQNQIQNQNQIQNKNQYPNPNPNPNQYQYQYQYQYQYQYQNQYQNQNQYQNQNPIQNQNQNQYSNQYQNLNQNFQELTDLQQYQQYQQYRQYQQYQQELLQQMENPDTERFPQNFSENPSENPLEDNLSTFILSSADEFKEFAKYLFVPDSRTSNTQATTIEPEKVKSLGGFVINLMSRYHEALQMRNYQHQQKLDNISNSFKQHNNLFKLQIAHLNNEIEKLNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX66</accession>
    <name>A0A9Q0LX66_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydro-n-acetylmuramic acid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000028">
        <property type="protein sequence ID" value="KAJ5079530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX66"/>
    <dbReference type="OrthoDB" id="5427593at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="92" mass="10733" checksum="51FE82280C486386" modified="2023-09-13" version="1">MIFSRDSFQRTIRITEEIENYSYSPFLIFFVIPSKEIIDYKEALIFAFLALLRKNNQINTLKSVTGAKKDSIEVDLLSRRIIFSGTSSYLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXH0</accession>
    <name>A0A9Q0LXH0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="221"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="257"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="443"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="481"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="519"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="592"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="665"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="702"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="850"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="885"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="919"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="953"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1023"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1132"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1166"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1371"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1473" mass="169515" checksum="B506896ED8367816" modified="2023-09-13" version="1">MGQSESIQKLFIACKNNSFQEIKFLIQKKVNVNAKNIYEQTPLHLICQNINENSFKIIKFLIQNKADVNAKNIYEQTILHLICQNINENSFKIIKFLIENKIDINVKDYKKQIALHLICQNINEISFQIIQILIENNSKINSKTKNKQSPLHLVCQNINEKSLQIIKFLIENGADVNAKSKNQETPLHLICQKENINEISFQIIKFFIENGADVNAKNKTNKETILHLIYQNPNQITFEIIKFLIGKGADVNAKTKNDETFLHLVCKNQKQNEDVFQIIKFLIEKGADINAKIYEGEQTPFHYACQNPYLSFQIIKFLVENGADINAKTEENRETPFHSACQCQNKESFEIIKFLVENGADINAKRTDFQETPLNLVCQFQESEKSIDIIKFLIENGSKINSKTIYKQSLLHLACQNQNKNSFEIIKFLIEKKFSVNSQETSEQKTPLHFACLYQIRNEESFEIIKFLVENGADVNAKTNDDQTPLHIICRCQAQKNSIEIVKFLVENGADVNVKTKFDNSTPLHLFCQSEFNENSLEIIKFLVEKEADINIKTGFGLTALFLICQNINKYSIEIIKFLVEKGAEINAKTHEQETPLHYACQFQKQEHSMEIIKFLIENGADINAKSHISKAPLHIACQGQKETSIEIIQYLILKGADINIKDYSQETALHLVCQNQNQNSFEIIKFLIEKGAEINDTNSYSQETPLHIACKYQNENLFPIIQFLFEKKANINAKTKYTLETPLHLVCQKEKNKDLDQIIKYLVSKRADIKAQLESTLETPLHFLCQKSKSIEAINYLIKKKVNINAQDSEMQTPLHKVFSSKKSKKNSFGIVKILVSQKANLNAETKYQYETPLHFACKQKNSFQIIKYLVENGASVNVLNNFHQESPLHYACQHQKSLKIVKYLISKGAIINAKSTNNQTPLHYACQHQKSIKIIKFLVENGAVINAADDRNNTPLHLVCGNIKEKSFEIITYLISKGANVNYYTNDHESPLYYICGYSNSFELVKLLIENGAEVDCKTNTQETPLHNICTRKNAIKIIKYLVSKGANVNAKTINDETPLYLACQFQKNQDLLEIVEFLISKGADVNVPTNYQKDTCLHLLCEMKNNSLLEVAKLLISKGGADVNAKTSHNKTPLHLSCDYRQPLDVIEYLISQGADVNAKTVDNDTPLHLACDFQQTIEAIEYLISKGADVNAKNSFDETPLSLSIKTPNEDVIKVLLMNDAKIWNINEKISNSKIFESLLSQIYSINQDMIKILNSNENFSDFQIECKNSFIFLVHKLIILSRFDNNEMILKKFINICKEKPKENVKFSLNFLYTGFFEENYEENDNEIYKEIFNEIGLDSKWIESKKGRKGIIKDFDKLYKQESTKDFTIIISNENEEEKEIKVHKLILIIRSDLFKGMFLNVKDFSNQVHDYSRKSFETLNQLIYFIYHDEFEENKINDKMIEEFADVKDYYQLNPNSIIDLILEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4N4</accession>
    <name>A0A9Q0R4N4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4N4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10298" checksum="FEA91BB088E1A156" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIDEIQIGIDYFQLNQTNPNLFDLLIIKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4W4</accession>
    <name>A0A9Q0R4W4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4W4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="125" mass="13483" checksum="AF67D66FC494E2B6" modified="2023-09-13" version="1">MSRASPESLAVFAKWISLIGGIGLMVTGLISIIVWANRGYGVGFGIYALIISVPIIMTEIPWPNCWIALVGPVLNDLRIRGIVWIVFSIPAFWVWVIIIAAVLVIIGGIFHLIAGFQGAGPAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5E2</accession>
    <name>A0A9Q0R5E2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho/rac/cdc gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5E2"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032425">
        <property type="entry name" value="FERM_f0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF0">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 19D, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16511">
        <property type="entry name" value="FERM_f0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="188"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="380"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="477" mass="55505" checksum="BC9FDB161D0836BE" modified="2023-09-13" version="1">MDSQEKKMAATLLLHIVYPFHQSTQTMDSSPVALVREIKERIFKINGLDMNRFEDYGLYCTSDNGFWLEEDRTLMSYELWKQESIEFRQRIALFINVKYQKQDKNIEILEGVSLAQQLPKITREFGEENFYDFSLFHGNHPLDRNKSITNQNIDDIQNASFTLVRKVKFRQDQNQIKKEEDSTPIFTYPLSYALNRGGRQHEVPRILVKCFDFIEKNGINVEGIYRKMGTSENVAKLKEFFDQTDDLEIESVTKSPHDTAEIVKLYLRELGEPLIPNSLYDDFIKADGFSILWEKMEFLNSLVDSLPKPNFESLKLLCQHMNKVSGASSHNKMTLSNLAMFIGPLILRKKVEETQQQYSICLILFQEFEFLFLKKPKNYIPDIYAKANFAFKAEREDELEFDEGDILEIISKKIGEEDEKEGGWWFAKSVVSGKEGLIPSSYVEMTRDYVPPRKGSSSQKHKGIKAEILSLEKNFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5I8</accession>
    <name>A0A9Q0R5I8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5I8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="259"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="482"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="588" mass="68222" checksum="90E6D8120F1D60A8" modified="2023-09-13" version="1">MNEILFFGHNASPKLLENEPEKITKPTQFKFENENENENEKQIKQILSSNSSVFFLFENGKLFESSEDSNQNPEKIQIENIQKVTFGNYGNEAILTIEGNVFAKGNNINPNNPNQFINISSLIEDKNDRIIEDIVSGASSIYLLTSNQNAYGIGSNSYGQLGFDSETLKKTEKPILMMKNVSKIFSGNNSFHVFLLNLNQELFGCGYNGNGQIGLGESRKETYIKKLTKIQNIPKGKIIDIQTSYYHSIMLIENENPKRKLYSCGYSQFNGLGKDENTYEFTEVKSSLFENDDNILDFSVGDNHTLILTSNSKMIGFGNNSHGQLGTEDTETQRIPIQIELPKLRFNEEISNYHLYCGSYHSFLYYSPSSFSNLEEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLKDQNQIEKLQEIISKKSIKESNQIFEMIYSNKFKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQILEYWIYSNQIKNGIQIIQEIIDDLETGIDYFQLNQTNPNLFDLLIKKFNNQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6B9</accession>
    <name>A0A9Q0R6B9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mfs transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_12150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6B9"/>
    <dbReference type="OMA" id="RFVRCLY"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="152"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="587" mass="65479" checksum="4AA11249240D16E9" modified="2023-09-13" version="1">MSNPKIDTEEEIEINSVVIEENYKSNNNTSINLQNLRREQNSRVPIMNITSSVSNYNKSSTSQNPFQIQNQNLAGKSNGTSNQDEKKIQIQTQNSKENLNENSKENLNENSKENSKENPKEDSKENPEKNPKKDDSNDDNEEKGVEKVDKIAVLTIYFCLFIAIVAFSILIPIIPFYAYEHFQANALKVGVIEAAYSGTQFISSLFLGVLSDKSFGRKKLLLICLFGLMIGLFVTSFSKTLLQLILFRGLTGFFGGFISLTNAMITDVVPIQYRAKYLGFFGGIFGFALAIGPTIGSSVSKWQLKGACYISAILTFIGFVFAIFFLKETYVVKKSLKFKQIVAIAEDVPVEGLTTFKALVLLIKRPFLVRFQLSLFLSNLGFTGVLIIYPMLCAKLRFGLTESNIGYIYMMMGIVLLVIQGGAIGTLTKKIHLQTMVYIMVPFGGAMIFIVPEATTVKKDILMMFLVSISSAFRLPCIMSLISFTTKRTDRGTIMGLAQSLSALSRTIGPIVGGSIFDANYRLGFWIAGCLLIVSGLMMLGPKIPIRKQKQDEIEMSSIEIDDGTLPEFEKKKNYSENEWFVSSDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6E3</accession>
    <name>A0A9Q0R6E3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6E3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="308" mass="37613" checksum="1C13E81DB81546B1" modified="2023-09-13" version="1">MSIFDDKQDELLEMIAEQKQTTTPSLNLSLNLGKKKKKKQTQPKKKSTQPTTKKTTTTTTTTKTTEKKEEVEKKEEVEKKDEVEKKEEIEKKEEVEKKEEIEKKEEVEKKDEVEKKDEIEKKEEVEKKDEVEKKDEIEKKDEEKKVEEKKVEEKKENQNKPKKGKSKKPQRTQINPEDFFQDSTQDRFKKFENIDKLSQEAFDSPRKFDNRNQGYRNNYRDKDDGNNDRRRNFRNDNDNNNWRDNKNYERPQRNNFDNRNKFDNRNRYNDRNKPEDNWRNFDKSNSNFRSQNLDSKRDYNRNFSDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6G6</accession>
    <name>A0A9Q0R6G6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Counting factor associated protein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6G6"/>
    <dbReference type="OMA" id="YEIDYTS"/>
    <dbReference type="OrthoDB" id="65740at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040471992" description="Counting factor associated protein D" evidence="3">
        <location>
            <begin position="21"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="5">
        <location>
            <begin position="227"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="314"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="62038" checksum="FA06734C7823D845" modified="2023-09-13" version="1">MKFTSLIFFVLFLFFAFSDPVPPTWPEIYHVDLLFSLPYANIHIPVSTDYDNTTNNERIIYYSGLTLDYYLTVDNYEIWTTQTNQTCYKNPEPHAVNQTLVGMFPDLSTWTYIGVGVARGFKCNVWEYIYQPPGYNKTNVYHFYVDFNTNSPVQYHMLGYDIVFGSHFDEYVMDYYSYIPNQVNPNAFVLPAICNNASSHPEHKFGRNSLHFKKLTPLKSSNSETLFDLFKSKYSKNYPNEKEQQERQEIFYNNYRYINEFNQEHTDMTLGVNHFADMTIEEFRSVMLMPKGMLQRKVNHKIEEYEPRIPTSSLPTNLNWTELGAVSPVKDQAFCGSCWAFSTVGVIEGQYYLATGNFKQFSEQNVIDCSWNATHPSYGCDGSSQEFAYEALMGMGGIEFEDDYPYLSVTGYCGYTPEKRAASLLTYYTIPNSEEAVIEALNTIGPLAISYDADHESMMFYSGGVYHEPTCSTTNLDHAVLLVGYGNYPGTEEPYWLVKNSWSTHWGYYGYFLIARKDNMCGITTDVTFPVLERNFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8G0</accession>
    <name>A0A9Q0R8G0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spartin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8G0"/>
    <dbReference type="OMA" id="ERRDWMI"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="217"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="427" mass="48169" checksum="620165E7CC12FC4C" modified="2023-09-13" version="1">MQNQKQTQQTINATLIFEIDNVIVRKINDNSKQILTQGKLQILKALYEQHEIMLLKINEIVSPLLKTKSFMKVAPLSYAFPLNENEFAGILLPKNIDEDSVDLFETFLYELTEFWSVDDEDENEDQETNQNPKEETKKPETKTKHRKKHTKPTKDSESDEDQVYYEDYLNQLEEEKMVEEFQTEKPSQITSNQEIKKEDQLEFDESIHPMGPIIGNKIRKGGAFVSKMLVSGAKKGGNLIRKGGEKLTTKIKKNEKEWKPSEKTKQRMETTKAISGGIVEVSTLLLKGAVETARYAGKGANTLIKKTNVGQKLKENTSGPKMKAVKEIGISTIDAGLNIFDGIIQSGKEIVKSTSDSVSTVVGHKYGEEAANFSRRGGEVAQDVTQTVGNLSSLTKRGIATAVVKESYKEKQEEEKQEKEEEEKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R972</accession>
    <name>A0A9Q0R972_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R972"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="310" mass="35727" checksum="D7EE709A476D5FB7" modified="2023-09-13" version="1">MGQSESKDLLSSIRNTTSKTPQKYLKIIENQIDAIALLDTNGVYVGFNNAFAHLFGFEDEEIASLTLINLFSMSFDPPFKDQNDIFETIKQRFQTAISRGESNYQWKYKNLDDDPLDVYVWINPVHLKDGLYYQAILRTVIDFDTKYSKIELLIAKPEISIREIAMFCLEEAVKITKSTMGYAYMMDKKQEKLSSICWSANAMKNCKMLTKTLVYNVEETGLWGEAARQRKPIIDNDYSKPNPLKKGYPVGHVPIIRSLNVPIFNNEKKKRIVLLVGFANKEEPYTDKDSENVAKIMGEFWKVAKSQFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9L7</accession>
    <name>A0A9Q0R9L7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9L7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="261" mass="31332" checksum="BEE5F96C45809DDC" modified="2023-09-13" version="1">MTESEKIDFTQSWNEKTQKKKTQTEKLGTDLHNSIFEEIQKRAQEIHDEQTALFRKNIEKKNDERQEKERIYEEKLDKLNQDNSAKAELIEEIKEVENCIIDPKIDNEDDIKQKRQKSQKSSPIFQKIDVNRRDFKTKLAEYEKLLIELAKTKHEKKRRNAIIEMKELRNARITEQNEQKNLYLNFLQDEVKHLKLTPKKTDHIRSLNKTEKGFVGPDFKTEKIFDEETDKDIDFVIYDNRFPKKISLLYVGNKDKLIQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9Y4</accession>
    <name>A0A9Q0R9Y4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9Y4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="33234" checksum="851B7B1BA5DBA459" modified="2023-09-13" version="1">MRKSKPPVKPKTSKISFIIAICLLICGIIWAFVEIITRLKLIETDCFINDKKYILYSYNGDGTPIISPNQLENQNQNQNQNQNQNQNFNDSKYLFASIGCNTSPTDNVVSFFNITWKSKSGKSFNEFSCNFGRMCWTAKGNNCKNTKCKNSISTKECKNFVDLEKKKIFDKYQVNTSVKCWISKSKENFATIHFPLPNFAWSIFFWIFSLIFCIAPCRNFQYYYCCFSDFHVEGRKIRRERMMKMNQIENENENENENEILERSDLDSGMKDKENLLKEEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9Z1</accession>
    <name>A0A9Q0R9Z1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9Z1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="197"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="431" mass="50744" checksum="624556D870763B3C" modified="2023-09-13" version="1">MHHGHHGHRGPPRGGGGGGPRHGHHRHDFHSPPNSPPPPRGPSPPPPDSGQTQKILDELKQLSETQQQIQKEKNQLLQERNEHLESISKLEKLKQEILQQKIQLENENKKQEELITQLKKENEEKDLKIKELVSQLESKNEENGKNESERKTFEETILTKEKLINQYKKENEENEQKTKESNKYLSILFENANTFHYDFTIFAGENNTPLKCHRGILMIRTPYFFNYCKQSLSKQIKLSDVDPKIMKMILEYFYTNQINLEGFDIELLKKSWVASSKFDLNELQKKINHKINEIISNENVGFILDLAIENESKELENICLEFLNLNDNLEIFSKDEKFFNINRLKKMRRIMKMAVENENFTKYLSLFSIYSEMIENYGKHIDIEFEHPKSFLESIIPKFSDSKITDEDCSNIYKLKFLPKDLKNLFLKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAB3</accession>
    <name>A0A9Q0RAB3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear pore glycoprotein p62-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAB3"/>
    <dbReference type="OMA" id="QQIEISD"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="3">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="3">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="3">
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        <location>
            <begin position="683"/>
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            <dbReference type="SAM" id="Coils"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
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    </evidence>
    <sequence length="782" mass="90542" checksum="9D7CE38DE31DC8E1" modified="2023-09-13" version="1">MFTHQNKTSIFGNRTQNQTPTQQNQSRTSIFGNKTQTQTQTQGRTSLFGNQNQNQNQQNQQNQTQGRTGLFGNQNQNQNQQNQTQQKSTLFGNQNQNQQNQTQGRTGLFGNQNQNQNQNQQNQTQGRTGLFGNQNQNQNQNQQNQTQQKSTLFGNQNQNQQNQTQGRTGLFGNQNQQNQQNQQNQTQGRTGRTGLFGNQNQAQQTQQTQQKSTLFGNQNQQNQQNQTQGRTGLFGNQNQNQQNQTQQTRQTQQTQQTQQKSSLFGNNKTQTQQTQQTQQKSSLFGNNKTQTQISTNPVLFANKSQNQNQTQQTQQTQQTQQTQQKSSLFGNNKTQTQQTQQNQQKSSLFGNNKTQTQQTQQTQQTQQTQQNQNQNQNQNQNQNQTQQNQTQQNQTQQTQQTQQNQQKSTLFGNNKTQTQQTQQTQQKSSLFGNNKTQTQQTQQNQTQQTQQNQTQQTQQTQQTQQNQNQTQQTQQKSSLFGNNKTQIQQTQQTKQNQNQNQNQNQNQNQNQNQNQNQNQNQTQQTQQNQQKSSLFGNNKNQTQQTQQTQQKSSLFGNNKNQTQQTQQTQQKSSLFGNNKNQTQQTQQNQQNQQTQQTQTQQTQQTQNQDQSKTQTKKVLFANTNQNPSKEQAKEKVSKIQKKNLRGIRDLWSEEIETSIKEFTVKAMETKNLDGEINKNLDKIIKFQKQVELAQQSFQELDEDLDSIESQQIEISDLIDRLDHEIDEIFANSTELEKHPVVIERENTYGLGVTIDSQLIFIRENLLELVTRFNLAQNHQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB55</accession>
    <name>A0A9Q0RB55_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="KNARKCV"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="198" mass="22382" checksum="440D67EF87C2F4B7" modified="2023-09-13" version="1">MKSIKCVIVGDGAVGKTCLLISYTTNAFPEDYIPTIFDNYSANLIINDQVVNLCLWDTSGQEDYDRIRPLSYPQTDVFLICFSLISPSSFENVKSKWVPEIRHYCQNSPLILVGTKLDLRDDPNVISDLKQKNLSPISFQDGMNMAKEIKAVKYLECSAFTQTNLKNVFDQAVLTYFDPNDSNTGINKKKKKKNCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBA3</accession>
    <name>A0A9Q0RBA3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase unc-51-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBA3"/>
    <dbReference type="OMA" id="QWFIVEQ"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="116" mass="13515" checksum="9086CE1CD3F128D5" modified="2023-09-13" version="1">MTICGTPLYMAPEVLREDSYNYKADLWSLGAILYEMITGYAAFNEAPSSKAIRKMHEKNTVKELPQKLKMDVPQECKELVKSLLTVDPNKRITRQEVKNHPFVLPYLNKKDEKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBI8</accession>
    <name>A0A9Q0RBI8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1015 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBI8"/>
    <dbReference type="OMA" id="EPVFFAY"/>
    <dbReference type="OrthoDB" id="5004at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454:SF1">
        <property type="entry name" value="DUF1015 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="LMO2823 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="50532" checksum="DB9C83B210DCF371" modified="2023-09-13" version="1">MVKIKAFLGYSPPKSLEKKVPSPPYDVISSEEARKFAEGNEQCFLHVNKPEIDLPEDTNPYSDEVYKQAKINLDAFIEKGYLVKETQPQLYIYAQTRGNHTQKGYILLASIDDYEKGLIKKHEFTRKDKEEDRTKIINIQNANAGPVFLSYSSKQSLDDFLETLSKRDPDFDFFADWEGERHQVWKVSDKKIIESIQGEFDSVPALYICDGHHRMQSAANVAKMRKAEIEKNGGTVTGEEPFNFVMTVVFPHTQLAIFDYNRVLFKQKKKKEELMEFLKQSFDIKEVEKKENVPDNTITPPHYAKPTEKRVFSMYLDKKWYYLHVHKDKVDESDPVKSIDSQILTEQILTPFFGIQDLRSEKNIDFIGGTRGYQALQNLVDKNDAQKQNDEISVAFGIFPVTMLELMNVADSGRTMPPKSTWFLPKLLSGLVVRLIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBL9</accession>
    <name>A0A9Q0RBL9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBL9"/>
    <dbReference type="OMA" id="ANGKFNT"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="224"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="757" mass="88839" checksum="64522E0B0F5D46C0" modified="2023-09-13" version="1">MQSKKSTKKSTKKSSKKSTKNKHKKSKKKEKKDKKAQKKEKKEISSKESDIQEQESDIQESGQESEKGLKSNENYSNSKNEKKSQKKEEEYSTNLDTKFTKIFSQNTKLKYDFELCSVFQPDFFDSIFDSTTKIHQHKKRIKPTKSLDSNTQSELNEISNDVVNSNKTENETPHKVKKPKDLIIDTSPSITPNSTRRITDLQSPSTPITPQSLYPKIIENNESGGLQNLGNTCYFNSVLQCLLNIPQLKQFFLKQKIPSKYPISFSFRNLMINYWKSKESSLEPLNELYKKIINRTSQFKVQRQEDAHEFLVYLLEKLDDELKVYNKEKNPQNKKQSTKIQDLFQGEIESTIKSQECTHQSTKTEVVYTFELPIQGKKLENTKEIAVLFVREPYKDSKVQIKLNDFPEFKKEIAEKTKLDPQLIYLYSEENSRFVKKIETTKELYNEVNRHIYAIEIEPQIQFGETNAIDSFPDNFPVEQTHIIGKSKTSKFEYVGYPFLIQLREGLFNKNKIFELVTLHASRITEKFRYNPNDVSKQTKALCKKYNFDLNEIKYFKLFLINSNVNEIEIFPTSENVKIEQTTKFRILWNPIISTSLPFFKMTYFQNLRLHNVVNKTTLKNCLDGYTTEEELNYENKWYCEICKKHVMAKKQISIKKFPKFSIFQLKRFDANGKFNTEVDYGDIIVLNSTGIQKPYYFFAAINHQSSSVSYGHYTSVVHIRESLWYHFDDNVSKKLDENKKSLSEVYLLFYTPEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBS6</accession>
    <name>A0A9Q0RBS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinitis pigmentosa 1-like 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="TITIREQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="912"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="922"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="937"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1610" mass="194328" checksum="FD91B41A145C991C" modified="2023-09-13" version="1">MELVIDNLKSTNEENKLLTRHIMILCENIVILPIIVEKIKDKFPKQEIKLLYGTSFHEDKKIQTYQDLKNIANLISEPNIIILCKFFSHISFGASTTRVNIHPLSRIIVIMEKERAYQNLSIAVLNRFEKQFITSNDFLNSTGIELRKQLRKNFKNIENITKTDHFKNIENITKTIPKTITIREQELFKGYSKHLIDSLSFELQQKENQNQNQNQNQNQKEKEFSMNKYLFQILKTESILQIQNSLIEKEEKEEEEIIKNLRKYLSQQPKNLNELISQINSSSENKNKHSIIITNSLASELKKKIQEQNEKEKENKKEKEYEYEYDIIQISNFGKRSEFEKEIQNIISKKENEKEKNLFIQIEENEKENIMKKFQYIKNIIEENDIFNNPKQIINIIILVHIFSNQTKFQICFEEKWENYYLEDLNPIFSFPSKFKFSLSSIYDQIIRLKINQNKNNQNNENDENNENNEIEPINENEKQKREEEIKKEIFEEIFEISFNKSNKNIKEYDEEIKKLIYKKFQESFDSNKIVNQKWEKIIELILNNKITSYFESLNSVIYRNWNDFSIKIIIQIIEEIDKFGNLNLYKEEYSKEIWEKCFDKFQIFEVDYQQLEKNQKIEQIEFPFKKESFIEIEIEKKEVNKNNQEIEKNNEKIKDQIEKITKFRSELFLINQEKTEQFDNIKNLINKFKNEAGIDLQNKNKNEKDLLFKIYNSKLQEQNQNQNQNQNQNQNQNQNQNQNENENENQNEKEKEKEKEKEQKIIFLRFSRFIKLIQFFESENQNQNQNENEIENQNENQTENQNQNQIQIQIQKIIFNEILNELEKLIEIFDLKLEDVLKFIQKFIQKFNQKQNTKQIQREIQNQIQNQNQNQNEIISTKLPKNWIWNSIPKIGINSLILLFENENENENEKIKKEFPITCENENENENESENESENQNENQNQNENENENQNQNQNQNQNESESESESENESENESENENQNESESENESENENQNESESENQNESESESESESESENQNQNQNQNQNQNQNQNESESESENESESENENENQNESESESENQNENESENQSENENQNESQSENENQNQNQNQNQNQNESESESENESESESENQNQNQNQNQNQNESQNQNENENESENQNQNQNENQNQNQNENQNQNENQNENESENENESENENQNQNQNQNENQNENENKNQNQNENENENKKEIYLSKTTLDEFCKQPKFKEYYCEDFCYVWNQYYLYKPNEKLILISPQTKLKEINETKEFLNIFEYFIQKYNKMIKILKQNFPLKNFQISCKKEIELIYEQEFPKILEIKKNEINSFIQENLIEEISSLHLIENFIQDQFKNIKFQKLQIKSTNFEEKGMKIEKEKLKQIKDKFEKNKFEQNKLGKNKLKQNKLRKDIIQELEHFRILPNSIYYLVILIEFLSKKEFKKEEEINEWKNLNIKTIITTKKIGKQVENQIPKFIHSILFGIIKDYIDECPNFANIKMNELIDLYKTLFKYFIDPCEKVDSKFKQHLSYQQKKEVKKFLKEEESNILKNILENILRRIENLKIENDPETENIFSFPDYALSQRLTEFFKELKLKYIIHLYRICYKIYQKKRRENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC55</accession>
    <name>A0A9Q0RC55_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_07700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC55"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="373"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5074996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="449" mass="52304" checksum="96C64D7B3DA8680D" modified="2023-09-13" version="1">MELEQEKEINPWEIEKFTSEDNPDGLLEVSTFSVIFPKYREKYLQSIWGKVTQSLKAVKINCELDLIHGTMSVSTTEKTYDPYIILKARDMIKLLSRSMPYEQAVKILEDGMACEIIQIGKMVKNKERFVKRRQRLIGPRSQTLKALELLTNCYILVQGNTVSVMGDYKGLKQVQRVVEDCMNNIHPVYHIQELMIKRELAKDPSLQNENWDRYLPHFQKRNLKRKEKKKKKKIEKKDYSPFPPPQLPRKIDLQMESGEYFLSEKQKYRNGKKAQKKKQISEEKRRKFNQIFVPPKEEDFSNQSQSPSQKNSNPISKKKIDKIKNGFNKNFRQNINANSQQKQKNEINNYLIQVPQQDDLKQPLKKPKKSKSKQNSNSNSNSNSKQNSNSNSNSKSKQNSNSKSKQNSKSKQNSNSNSNSNSNSKQNSNSKQNSNSKQNSNSKWNIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC71</accession>
    <name>A0A9Q0RC71_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC71"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="359" mass="41517" checksum="DB3799C18EB0E73E" modified="2023-09-13" version="1">MKIGFVILQKIVIIQKSNSDISYSLDTDAYNYEVDEFLDDDTQEQFIFYILSKTKNKLRLKEIVSSTLNSACCERLISDVTHVIYSKEDEESEEYKEALSLKKILVKDEDVYEFFDDPIKLTNFLKSNRKNSNEKTSSYKKSPILVNSTNFGGLKQLQTPEKFKHELSNENTPLSIKKITNSKNPNSKNPNSKNPNSKNPNSFQTIISPCKIVSPTTTSPKNNLEIIDVLFSKQKSPSHKVKEKYLENLENSKQNQFRRSDLNIFSQFYDNSQVEKNDLKKTESKEKNENENENENENDNENDDDEPNPIVIWENSNQENGKNIQTFSSNDSDVDLFKINGSGSKTFIEAYHKMKNKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD01</accession>
    <name>A0A9Q0RD01_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD01"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="375" mass="43226" checksum="E9D814BBAF17C7B8" modified="2023-09-13" version="1">MIEEDIGYQAIVIDNGSFEIRSGFAGDDLPKKNTRNIIGNLINESNLINLSKSQYIGNEAQENKEILNLSYPIQKGIIENWDNMEKMWHHIFYNELKIAPEEHPVLMADSPFNPRNSKDKIKQIMFETFNTPAFYLGNSGILTLYSTGRTTGFVFGIGHEITFTEPIYEGYEIYNIIDQYQFGGNDLTNYLIKLLKEQDYSFEKSNDTEIARDIKEKLCYCSLNFQQELNQNETELEEAYELKNGDIISISNERIKCCECLFEPKIIGIDLEGIHKLIYNSIMKCDISSRKDFFNNIILTGGTTLFPNFKERLEKEIKQIIPDKMEIKIIADPDRKYSSWIGGSILASLSTFQSVWISKEEYDESGPSITRGRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD28</accession>
    <name>A0A9Q0RD28_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD28"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="22760" checksum="A3FD62A8C85C5B85" modified="2023-09-13" version="1">MDKNPIISIIGNGGVGKTSFTIQFCYSQFVEEYDSMIEESFRKQIEIDNEILIIEILDYHYYDEWNNRIKQKIYEKTQGFIVVYSINDKYSFNELENYLNEIYKYKKVNDFPIIIIIGNKNDLEDERQISKEEGNEFAIKHGCPFYETSAKTRYNIEETVFTLLREIRKYPFDSKSNSNSNSNSIQIPNQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE06</accession>
    <name>A0A9Q0RE06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE06"/>
    <dbReference type="OMA" id="PGHGKKM"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="168" mass="20113" checksum="E37F63CE2B0DF4DF" modified="2023-09-13" version="1">MKLEICSFSGTKIVPGRGMRFVRSDGKSFIFFSKKCYSLFDNKKNPRKIAWTQFYRRIHKKNEDAFIKKKKTRRVQKYQRGIEGASIEQIKARRQQKPEVRQQLREEAIKELKARKQQKEEQRKKLSQQKKKVSKDTKVAQKISNREKKKMQKSQNRGKVSQQSGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RET1</accession>
    <name>A0A9Q0RET1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_06896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RET1"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24363">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24363:SF0">
        <property type="entry name" value="SERINE_THREONINE KINASE LIKE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="13">
        <location>
            <begin position="49"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="791"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5076034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1271" mass="148848" checksum="268828331E521CAA" modified="2023-09-13" version="1">MNENLSENHPWRVKNQIPLDRNLTNQEFNKFLKEISEEENQIVIQIGDFVMESEILKNFLNGKNMSDLIIEPFFYLLSQRSQRENYPPIISMDCFFYEDLSTQGYDEVKARVYCTSPIKEPPIFLIPFHPNPEDWALAIIHFPLQTMFLYDPFHNNHKEVAKNLLEWFQKEYQQKKETIFDFKVSPNFNYKNVKKIVKPETSEDTGLFCCMFAYYITHPNIPFDYKLNDVQDFRVELLKMFMNNRVDPVGTKQEEIEEQIQTISNEEKQSTEHSFLQVLYYQNTRFCKIINYLNYLLAENELSSSLEECMELKEYLSRFLQSIINAIVDEVDVQSVDGFDWETAVSNYEALEDLISVIEMGMKSNVIKSDEYSEEMESLVSSACTIRSQILGVVMQFFEEFHPSELLSSIQSSQKEFDETLELLEQKLSPTIFKYDEFENQVQLLGDFSRALDISFIKSQFIELLKYKQYSLQINALMDKLLGLKDFEYLQNVLQERQSILDKFEQFINNTQNHMQISTEIQQIFELQNFENAQDVSLQIQERDELAKAISVDSKILRNGISNLVSEISNLYPKDENSLSKTNFENFQTDSDQFVSFVSSLKNINQIAQNLEKVFAENSQSISALLEQGLRSIIEANQPLQILENNNFFQFIDNDLIFLTDQDPQKEYKLSEISEQFESVFSQCSDYKSRITTSEFFYHILPDLDKKLQFLKEFDFKISFHFLKKKAIEKIIDKEQKIYPEITKLSQDLIQAQISARDLMDKYPMDEKALKSIHQLKSDHQSWKRIFETLQREKLFLYNSNFPELLYSNIKSSNTDLSQFPLDFRFVSRSIEEDYIKINTNFFQLKETKNTPKCMLIKAEYPLEYIRLLLKINHPLISPIQSYFYSKSENAYYLQLPYYPNGNVSELLKRGINRAQFILILQEILIALDHLHSQSLINNQINLDQIFVDQNGFAIVSPPAPEPDFSRSIDFIAPELVKSYKNGEKYISSKESDLYSVGVLMKKAISFISELSEDKQFISISEKLIDSSPEKRPSANDLLNDRLLNQNLFEDYDPITREPKYKLLPIDQSLFNILNKIPHEGINSISQTISKTPQIISVQEIKNPILESQFSSIKTKIYNSIQRKNKTPNDFEKYLYFDKIFLNNEQDCDRICKFGFSSCDFISGVFGKGLYFQSNENNEVGSFLDQKVEQEKKIIFENKENIEEKSFVLFLCRVFSGSVFQTKNTLLSLSEPPQKDGIEFHSVLGQKGSSKRHVIFNPLFVFPVFKIIIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFT9</accession>
    <name>A0A9Q0RFT9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-tubulin complex component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFT9"/>
    <dbReference type="OMA" id="GCSFANC"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="314"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="430"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="775" mass="91211" checksum="570FEEAF5E1A395C" modified="2023-09-13" version="1">MSNIYFKKRIKQPSNPEQPIFIFDNTLDISLSSLLHQILPLCTNFYIISEFVDSRFDFQYGLTNHAFCAAINQLLQDYHSLVTTFEYQQRTGQLTLQKLWYLLQPSIKTFATLSRLIIESKKMKARGGQLINLIHQQNNLFGGDTKTMELFEYLLEKAAQPYLEMVGNWVYKGSINDPHSEFLVVENKRVHKENLKRDFNDAYWERRYTLRKDEIKPSRNYKSRRSHEERERLRSSPDSFLSSVPFFLALSTEKLLMTGKYLNVIKECGIEINYPYEEKFYYTPNEQEYIEMIDKAHSYASTLLLDIMIKENKLFDHLNALKRYFLLGTGDFMSLFIDTAKEELDKNVIEVVPSKLVSFLGIALSSSVSSRDLMKDNLSCQLLPNNLISQLLTILNIKHLEKEKADKIKAKFTGKNMFVYQAKNPIKSEEKELFEKIIENENQNQNLNQNENDENESDENIPMLDAIINQQQPNVTGFDAFSLDYEVKWPVSLVINRKALTKYQIIFRHLFNCKKIEKQICDTWAAQQSTKEIDLELALLGAYTLRQKMLYFLQHLQYYMHFEVIEQNWKKFIARLADVSSVDELMLYHNDFLDSCLKECLLTNPRLLRIMSKLLMTCEIFSTHTTRLTESLTVTKHDELPLESRLPSFSSQYNDSLSDLLTPKENQEHLKSIEDHKTRFSKRAQRIDVQTAHVHKMFQEKGYLGMVRNSEEKFIFHLGMLIKSLQAYTHTDADPHMIDLITRLDYNNFYSKFFDSEEFKELRRKNQSSLLFKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGB9</accession>
    <name>A0A9Q0RGB9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of g-protein signaling 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGB9"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="249"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="385" mass="46112" checksum="0279200B538B9A49" modified="2023-09-13" version="1">MDFQIQKIVDLNDRSVQIVSPNSKQMDISRNITPVRSSHLLRQENRSFSFSAHLFNSEFQSSRHHSPTPNYHKATDFSGLKDKRVLLKRSNMTTSTPVKEESKENINYNKPKSPQNLEKISPKKPRKRKSEEHIPIQKEIPKKEPKKTELKRHKSFSMILNQIKKIRTRKKKPNEKQQKPKRILEKEIPKKQEITKKILEPISAKKTKPRRSRKIKKTKFQKQKENKKKETDHDQKEEIEQKKRFLVHKFDEVLHSKFALGYFRSFLKSEFSDENVDFWATVQVFKKLNKKSDISKMAQLIYNKYIKEGSQREVNIDYLDRRKVESVFLKGDYDKALFESSQDKIYRLMETDCFPRFLKSQFCNDLIIYILQNQKDIQEEWCKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGJ4</accession>
    <name>A0A9Q0RGJ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spatacsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018754at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028107">
        <property type="entry name" value="Spatacsin_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14649">
        <property type="entry name" value="Spatacsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spatacsin C-terminal" evidence="2">
        <location>
            <begin position="2302"/>
            <end position="2604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2658" mass="316284" checksum="100D44D9032125F3" modified="2023-09-13" version="1">MISNSLTFSIQNFNSNCGIENFENAKLNFPFLAFLSNDNKKLLIAKFKNLKSQPYLQKISNLEIENIKNFYWQTIEQTKTKYLFICDTSNVIYIYYFINKKMFDELENSSFEKKNFLQKGILVDFRNEMANIVKITFEDENQMENEDYNFVFKCKITPKFINEILYTKFVSIKEIQTIQILNLIQSSTSTLQSTLIIDQKYSLVCSFHKHKVICLNTFSLSLPKHVQEMYFYSTSKFLFGDIIPRKTSRIFIWNISNGSRIGPITSTITTKVARKNKIFVTPDNLVVVLFAANFPSIEIIELDKYFRNHSTKTKLKQEKFFSFKKKFVEFTESVITSFQLNFKTKEDKKEDKKEEKEKEEKESKTKHKRSKSHSQLIKKDDQEPDSMHEWKIGHFVISKKQLGLCLPIKRSQIPFIWHWDKMIHFSSFSQPYSPYWLSTPKNFLHSKYNGFNFQSSTFQMKIQKEESKTKAKNSPSRSKKRDGKLTHHHHKSKHHKKRKSQQQQQQKLIISDKIFSFDDTVSSCFFYIHDSNAKTWKLYRKSDENQINQEDHFDIKMDEDPAIFFADPHIVFHFRKIKNFESQGVLYFFNCKKHSENSRMLNYLPIDSNIFSFQSCCGKIKSLFYIPQKTFSFQFTLLNWEKQNFINYLLHLKTPEFVEKLHSLNNWEYPHSFFSDISKIAIETQSYDLIKYSFSKMNQHDSHSVFKYLVNSSESKLKYFLPHFTRDLTSFCLFFVSKFLLQISSKIQENTEIESEAIEKFLNELQYLIPQTDSIFLKTIQDSFIISDHENQNQNQNIMMMLHLHNLIQKIRSIYKMGYNQFHQLAKQYSERLKMNESKKQNTKKIHIQKKIIPQLHSIFFGRDNNKINEKTCLEQILSSLSHNEISRSCSLLISTKLYKNLKKIDSQLINNIQENKNYMDTLKSITLNLVYSMLQKNAKIKKIYQLLRGMNLDPLYILKNIAQSTLDRKIHNTLLDHMIQKDVFTKSQIEDALFLEMCEKVFPASDYLSQLNSHEKIRNIMFQDDLQIIRSLEEKSFVWIRTIKISQDDNWNPQTLFDNYSSHLQNKNISDDGIKFQNLFPALKSFKKLIDPQPKNSPHQKSSLNQSGYFTAKLNWIQNWDHETRQRIMIEKNNSLKNLPQKEYSWFSQLKYFVCHFNPLRLSLPDLSSLTNKLKSSKFSQILSLCSPAIKKFILSHSTISDPIHFTLQNESQILQNLSSNSKLFSSQNTLNEIPKEFFNWLIFQFIENNLVNLIIFISYHFPKIINFQNEKISNFPLIKFLALSSENEITNLINDQEKIINNLCQINKTEPENEQDMQEIHLFKILGEFCLSKKFLSHSEYFQQEYSSNFWKALSNFFPKFSLILKQTFSQLDHKTSHSKIQLKYTDQGYSKIELNDRIFFSLKQAKPILAFKFWLLMVFEKQISTSKDIQENTENILDQEKRSISFPILEFSLKNFLISSIISSCASFLTLLEVNPERFNLIIWSARLMFAYFLNENSIQSWNFDRTIKENIELLNRKGNQNVEKVVQKIQNQIYAKIEKITKENPDQNDKMETYKVLNLTINFLKKEKNNFQSKFWNQQSPDLIIRFRNEFRIEEKQENLSPLEKIFDLNLNWAQLLYWIDNLEIPDLQIPSKILETSSNIHQSHFKMCLKNSIQEQPPKIIEKEKIEKKTNIFETSNEISEQIKKKNQIQILDNPYFLEKLMNNQNSFIILLISSLLKKEDNNSYDDDIFLYVFNSKNEKLAQKDWVDIIKLIVKNKEHFASFLFHLTENHQLFVVIKSMQIFYPENLHLINFLHFVHHFSNGHYSLSEKYLRKVSLQNEDNIEEKIHWEKIFQQKCIEKFLGSNNFQTKIFLDLVTKCSENEKYHFLKRILDIFQEIHNEIPQLNILNNHEINLVLMINQNKFSHAKRFCKECKIPYFRGKLQKIVVGAMQEHVNEKWHSFKHIIANNDVYSKEILQRNLSFRLFELIKYSIHFVQKKENLIERIIWRRRNLKANRDIAQALILQNHQKIPEMLLIWLPQYTQEFIQLTQLENDKSEQNIIQKETRKVNEEEKKILDQVFDHLLNHELVDKAQKIAEEYQYRPHQILQMKICKQIASNEQITISQIREFFTQETQNIQISNLTTIEQRIDVLKELSLKNETIKKTFGKYIFDYKISQLIFKEISFVEDNPQEALKHLFGYGHEALQTIRQFIAFHKKELKEKLPEITATLLYETLSWKIEKKTKHSAVNATKFSISKFMSIENIVISSDQTFEKSPSFNEKKEVESLDIFQGILSVLENKKGFEKIVNLSQDPISIGNLLFDFAKDKKKPTTNKDELDIELIIASYKCFQISFDPRGFDKIYNFVHERAPQYFQAGKLNLLSRLIIHIRDQKQVEFMLEFLFQQNRLDAILVEISDTEEYDHIKNSLFHFLKKNCPSDEEKLVLYYCSFDMWNELGNFLMENALSKINEIASQLSIKDHKTNFQIIKKNFRELNQSGQYLYNAIHEFEKSKQFQKIITCFSFLIFIVVQSQYPNLNILGMIRIKNVKREMLYPVLLSVPNFFHALEIVETLNFNQFEIWSEILFSQVLLKQNWGYLFNFFQIFHHDKELYDQVVTFYNSYPKSSGLEERMKIFLTNMDDQQFQYELACANHFDDLVHQLERVASFHLLKQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH83</accession>
    <name>A0A9Q0RH83_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000018">
        <property type="protein sequence ID" value="KAJ5079977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH83"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="118" mass="13784" checksum="E74AC3F14D5924CC" modified="2023-09-13" version="1">MQKERKSRKRKSRNLTNRKTESLAIIKTRNNCIFGGFTEIGFVPKKGFSKGFKSNGKWNPSNTIWFGNGGYIELKIYQQKGISDFGYRDQGFEMPLGMKYGEESRNFCRIKELEYCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5A7</accession>
    <name>A0A9Q0L5A7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Piwi-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000140">
        <property type="protein sequence ID" value="KAJ5066557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5A7"/>
    <dbReference type="OMA" id="IVHYHVD"/>
    <dbReference type="OrthoDB" id="445936at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="212"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="486"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="789" mass="91294" checksum="2344BD1B96B9F5AC" modified="2023-09-13" version="1">MTDNDLLAKKHQQDNQQPQSQVKIAPSLVPTPKFGTKGTKINLITNYFPLNASTGQTYQYRVSFDPPVLSRRPRSRMLEIIKKSMSPFVYDGGELVYSKERFEDFTKEISFRRTATKISFQHTNIITPTDTYSISQVLNITFSLVLQALGLQQIRRNYFDSKKSIKDERSHSELWQGYQTTIYDTKAGLCLNLDILNKIIRTDTVYDKLSTLYSDYYHQYSHRELDFRDRGFQDFIRKNLKEQSVMTLYNNRFYTITDLDFSKNPNYEFKFKDKTISLYRYYQDTYHLKIKNGSQPLLLIKKETKTSDGQKSHNLIYLIPELCYMAGGTAKKAPVPKPFMRHVHVPPRERIQRLLDFIKQMNSDRNSQEILKLWQFQVQSMYCKVTGRVLPSQKIMVQDRTITPDQTANWKKDMRNVKLIKTLKFPKWVIFHSPNFNTRQFESEISKISKGLEIPFGKPKTVSCRFDHYDEFSSKIRDELTSDCSLAVFILPDSRKDHYDMIKHETATRIPIPTQCILGSTISDPKKLSAVCGQIIMQVNCKAGGALWGIGLPKRDIMYVGIDSARDSQNKTKSITAIVSSTNSQCTEYYSSIVIQQPRQESITGLTEVFHKALDQYYLKNKGKPPGHLIIYRDGVTDPQIQLVLEKEIPQIQEGCRKCSPKYKPHITYVVVQKRIKTRFFDGDNNPPPGTILDQDITTPNRFDFFLVPQKVNMGSATPVHFTCVYDSANIPADALQEVTFQLCHLYYNWSGTVRVPSVCQYASKLTSLISQSVHEDIRPELKDKLYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5R2</accession>
    <name>A0A9Q0L5R2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5R2"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="285"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="461" mass="54515" checksum="672A39BD9E993CB3" modified="2023-09-13" version="1">MENYLNLEKLSNDLKNLFQNQNQNENQKESYFDFEIICEQNKTSFKTHKSILSSRSQYFKSLFKSKMKEYQENKLILKDVSSSILFSILNYFYSGKIEINLENAIEILIFSSKYLIDELIEISSNFIKNNFQFETIVDVLKLSESMNFNQLLDSCYKFISKNFDKFIKTSFFLELEENHLNSILINDGIEINEFELFQSIIKWGKYKSNINQISNVIEKIRFIDFPNEKLGDILKEDLIPNQISQKLIQFQKLQNQNDGNELDQFIKKENQNSLIFKTRIKLSEIIQENKDINKLKEWINDNEFFSKMKKGFSAKRDGFDSQKWHKSCDDKGKTLVIIKTKDNFIFGGFTQVGFKPSKRGIWIQDENAFIFSFRNDKNDRKPEKFPIIEEKKEDAIYSRENLGPLFSNAIYLNSDLQPGYSNFGYTYNLPDGIEYRTDEARNYLAGSYSEWVVDELETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L730</accession>
    <name>A0A9Q0L730_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rcc1-like g exchanging factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L730"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="483"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="588" mass="68362" checksum="FF184C0DC6265B2C" modified="2023-09-13" version="1">MNEILFFGSNQYPILFKNKADKITKPIKFENENENENEKQIKQISTGGFATIFLFKNGKAIEYLNENDSKQNPEKIQIEENIQKVTVGYQNEAILTKEGNVFAKGSNINPNNPNKFINISSLIEDKNDRIIQDIVAGFNSIYLLTSNQNVYGIGSNEFGQLGFDSKAFQKTEKPILMMKNVSKILSGNYSNYVFLLNSNQELFGCGYNLYGQLGLGESIKDETEIQKLTKIQNIPKCKIIDIQCGASYSIMLIENENQNQNQNPKRKLYSCGDWQYNGIDEGTYEFTEIKSSLFENDDDILDLSVGDFHTLILTSKGKLIGFGHNEYGQVGTGDTNYQSIPIQIKLPKLRFNEDISNYHISCGYYKSFLYYSPLPFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLKEIISKKSIQESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKKGIKITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7P1</accession>
    <name>A0A9Q0L7P1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A-macroglobulin complement component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02891">
        <property type="entry name" value="A2M_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0882">Thioester bond</keyword>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="4">
        <location>
            <begin position="812"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="681"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1527" mass="174339" checksum="407F158F377665C0" modified="2023-09-13" version="1">MGQKPTKKKPENEQKTEEKKEEKKDEKKDEKKDEKKDEKKDKEMTPMETVYFGSTRYSLLISTDKKTYKPGETVYIRGILLEAFTHKPVENFAGNGNPYMKILSPKGDTVLESTISYQSDSVYSFSWAIPEDSVGGEYKMQIYHKSGKGIPINERGFTIRVFRPPRLKSDLEFIQKAYGAGDEVKASLSVERAEGGFPEGANVTAIARLDNEEVYRGDYVLDKNGKCIISFKLPDEIKEGIGNLNCSITDGGVNENASKTLPVVLKKMDVQVFPEGGELVYGLKCGVYFEAVTPSGSPADFEGILVCSKGDKLNKDIKMKTNHEGRGRFEFTPQKEINYEIKIIKPAGVTVPVQLPEIKSEGVSIISNKKSFHFKEKISITISSTRKEEYIVGVYKREKEISTKEIKFKKERESQKIELETKENDGILRITVWKKTDLTPMAERIVFVHPVDEIIFEIEPDKKTYCPGDTVSLTIKSKTKSGKPIQAICGVTVTDDSVFKMTEKRERPPRLPAMYFLENEVEHLEDCQIYLSPDQDKDKEKEKDNQEKEKLEKFTELDLLLGTQGWRRFLKIDEKLLDDPDKEKLEKLFVVYCDPNILSREIRKVKRKDEIQQIKTNVLNQEIFKEEKVFERDAILENQIQMNFNEIDEIKRKTSIGDEMEQPQLLIMEMEKAPPPMLEMKQKQQLPPPMPQMQQQQQLQPPMPQKQMQALAPPKPMPAMAPVPPFVQKKIMMEEMEKPQMKRMKMKPVMMRRREMEREMEIEEDEYWSDEDDEIWDDEVLAPTPTIPYFREFIHRRKPDRQPGERNDFVDTLFYISSIRTEKTKDIFEQKIEFDLNDSVSSFRVFIDGFNSEGLLGFSESFVVDSKEPFYLEPKFPLEVSFGDKINLPVALVNSLPNDMDITLKTEILSKSLAIEGDSEWKGQLKSEERTKKFFNLTVNQSLEKAKLKINGNDTKNPAIKDQVTREIEVKPAGFPLSLDVSGMLEPEGTVTQKMTIPDEIIEGSITTYCSVFPSPMGTLTESLKSFIREPCGCFEQTSMTVYPLTMAQQYFKTHTGVDPNFVTESNEKLERGYKRLIGYECKKGGYEWFGEDPGHEALTAMGIMEFTDLSQVFPVDQEMLKRTTSWVLTRINKSKGVFERNSLALDYFGGAPPHTTDAYITWALSESKIEYKELKPVVDNLIKQSQKEFKEDSYFLSLLSLILFNFGFKDQSLELCKKLTALQNKESKDIKEKGHLTKAKTSITRSSGFNLNMETTSLSVVSWLNFPDQFAENIEDAMQFITSNCKGGNFGSTQSTVLALKAIMKYDIYSAKATKEGSIELIVNDESVEALGFVPDQKGAMIFPDFSSFLQKGKENVMELKMIEGSKMPFVIQLSLTTPKPDSNPNCKVNLSTKLISTNKKESKTNTIKQGEATEIEVIVTNKTDEGIPMTVAIIGLPGGLEVRYDQLKELVKKGIIASFEMIGARELVFYWRAMKPKEVIKFSVDVIAAVPGIYTGPSSRVYLYYTNDEKIWIDPLKIEILPDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7R8</accession>
    <name>A0A9Q0L7R8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fmrfamide receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7R8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="445" mass="53511" checksum="1B18943AF0C8E813" modified="2023-09-13" version="1">MNEDEVPVQIQIRKQLKGVSIKIDDLPKEALNHENPYFRKTFHLKKGKHHIILLLEEWSKGDKDNTIDRYINITKATTINVSDGLDDLDDNQNENENENENQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIENENQLQNQNENENEIKIENEIKNQNQIENENENENQIENENQNQIENENQNQNQNQNQNQNENQNQNQNQNQNENENENENENQIENENQLQNQNENENEIKIENENENQNQIENENQIENENQNENQNQNQIENQIENQNQNQNQIENQNQNQIENQNENENQIENENENENENENENEIKIENEIKNDEIDEMQERIDLGYYIKKSSKDMLAILFLFKIFEFFFSFFRKKKPEQRNENKPQEEPQQKQKLKSISHIFLEFFKPVGMLLLTILFVYLSFISLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L859</accession>
    <name>A0A9Q0L859_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L859"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="229" mass="26594" checksum="F803E8A85431EB2F" modified="2023-09-13" version="1">MRSELYRGMFLFVTEDKSNKATDYSGIKNYSPMLFLFENEKAIEYSNKNYSFQNHSKIQIEENIQKYCFWIWFLIYLLTSNQNAYGIGSNYFGQLGFDSKHLIKTEKPILMMKNVSKIFSGNSSYFVFFLNSNQELFGCGDNHYGQLGLGESVGSQIPKINQNPKYSKKAKIIDIKCADSHSIMLIEEDDQNQNPKRKLYSCGIIRYNGLGKNEDTYEFTEIKSSLFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8L1</accession>
    <name>A0A9Q0L8L1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8L1"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="289"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="475" mass="56321" checksum="00FED84F41534752" modified="2023-09-13" version="1">MENYSNLEKLSNDLKNLFQNQNQNQNESYFDFEIICEQNQTSIKTHKSILSSRSEYFKSLFNSKMKEYQENKLILKDVSSSILSSILNYFYSGKIEINLENVIQILIFSSKYLIDELIEICLNFIKNNLQIEIIVDVLKLSESMNFNQLMDSSYKFILENFNKFIKTSFFLELEENHLNSILLNDEILINEFELFQSIIKWGKHKLDINQEKELEKEEKEQIQNQISNVIEKIRFIDFSKQELEDILKEDLIPKQISEQLIQFQNQNQNQNQNQLIFQTRNAFKFDSIIIQEKEDFSKLRKWINDDKFFSKMKKGYSTKKEGFDSQKWHSICDNKGKTLVIMKTTNGFIFGGFTEVGFTTDKSKWREEDIDYQNGYIRDSKSFIFSIRNARNELAQKFMIKKDQEQNSLYYFLKNGPSFGGSDIRLNSDLRSGYTNFGYSYNLPKGIEFKTNEAKSYLAGSYSSWKIEELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8W4</accession>
    <name>A0A9Q0L8W4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidyl peptidase four (Iv) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5068005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8W4"/>
    <dbReference type="OMA" id="GNDCPAN"/>
    <dbReference type="OrthoDB" id="10264969at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42972:SF8">
        <property type="entry name" value="POLYHYDROXYBUTYRATE DEPOLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42972">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040456346" evidence="1">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="326" mass="36168" checksum="F80EDE9AAB33EC6C" modified="2023-09-13" version="1">MIIHFFLFLFLFWIVIALNINTSAVSVSGISSGGYFAVQYHVAHSSEIMGAGIIAGGPYWCSQANVDIALTSCMTDPILISVDVLIAETYYAEGLLSIDPVSHLRDDKVFLVSGLNDTVVVQGVMKKLQTYYEKIGVRSIQTNFNIEAEHCFPTENYGNIPCTFLGSPYINKCGYDMAGQILQNIYGKLKSKVSYNPNNIRTINQHDFVPLHVDPELIGINSKGYVYVPTNCANSKSSCKLHVVFHGCLQSTENIGEVFILNAGYLEWAEANNIVVVFPQTQSNVLNPKACWDWWGYSGVDFATKIGPQIITINNIINYIESSKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB05</accession>
    <name>A0A9Q0LB05_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB05"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="197" mass="23336" checksum="162C438594F32298" modified="2023-09-13" version="1">MEIEIGIEIGEKIYIEGFLLKKGLIVQSFRKRYFVANQFCIKYSKKENEKPRGIIFLSDIEKISMLEEKFLQIFTPTRIFFISCLTKINRDKWFKALNYLLIGYRQEVSLDDEYFQKRVQFQPETVSESEVEVEVEFESQLQSFSNGEEKINSFDLNKQNIPKREKLEREVFTVSNKKPETKSIKSNQEIAMNPNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBY3</accession>
    <name>A0A9Q0LBY3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inner membrane protein yaah</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBY3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047623">
        <property type="entry name" value="SatP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30178:SF3">
        <property type="entry name" value="SUCCINATE-ACETATE_PROTON SYMPORTER SATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="266" mass="30412" checksum="A989187EFAD2B7D9" modified="2023-09-13" version="1">MSEQISTQTDEWDSIHTDQEKQKTETEIEMKEITSTDSQPLLVKRQEIRPTPRNRVRVAKEIANAQTKDNFLGPTQLGYMGLSFGSFVVAVLNLGLWSENIQSLYWFVLIPAILVLLAAILSYLLHNNLEASIFFVLSVFLFAVSSTWVVDLWDNLNPLPPGKMRLLASFFVTLFIFLVFFTFFTLQMAQMIFWLFFSLSLAMFFLIFRIIYSANNILVGVPLIMTTCLSVYLSVSLTLNNLVGKQVLPLGNPLYNWSNFNLHLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC19</accession>
    <name>A0A9Q0LC19_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC19"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="90" mass="10812" checksum="21D983310E490115" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIINELDRGIDYFQLNQTNPNLFDLLINKFNNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC83</accession>
    <name>A0A9Q0LC83_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_11064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC83"/>
    <dbReference type="OrthoDB" id="7903616at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="10">
        <location>
            <begin position="560"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5070217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="813" mass="96287" checksum="3B143081DB88D64F" modified="2023-09-13" version="1">MNNNSKSKNTTIKVSKNTIFSLSKDTLNKSKIISSQNSNSPISSQSSSQNSQFQSQIVKNLLYRDVWEEIKNDPKSLLSFTGEKRQTIEFLINGIQTAFPNKQNSSPPNSPSRNEKLVDLPNRLLILLTWIKHYCSYSFLAVIWRIGTTTVKRYIEEVLTQLKTILENQIQFPPREELIRLEAEWNQVGLPSVIGVIDGTDFPRSRILKDEKAWYSMKRGTSCMKAIVVCDRKGVIIFFAVGFEGSMHDSPAVYACDLDKKLKPYKVLGDKAFHHSYSITPFKKRKKGFTKEQKDRNDLINKERSIIENVFSILKVKRILREKVRLNLHLHKAVILVCAALYNLSAKGRTLRKTTRNEKETKIYEKKQENKKVIKEIKRAQKEEKLKKEEEKNKSKMENKQQRKRRKTTKKGKLNEEKKINIIQNDEKKASCDRNNSNSEPISKKKDKQKHKSKDKSKDKSKDKSKHKSKHKSKHKSKHKSKDKSKHKSKHKSKHKSKHKSKHKSKHKSKHKSKHKSKQTEKEKKESEKNERNIQEEIGKQQNMQQNLDLIYNLENIDQIIETLRINESLDPGRFTTWRDRILSWIPTKNWFSTSDIDNFFQILYCYKRPQHLFIFDSGNLEMIRSQIIQNSELLAIKNEWIIPLFYQHHWILAVFHRNKNELEIFNSKPHQIYSRGINQLNSLLKAKLKVIKWKQKELQKNSNDCGPFICLFGFLRCFLRWECPQIVNFIQKKHGRKTRYMLAFLLEREEVQTIHFRIRRLYQQIQFLKNKLEEKGKEDPNLRAILNTISLKFREIFFWESFPFHNFVEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCL6</accession>
    <name>A0A9Q0LCL6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCL6"/>
    <dbReference type="OMA" id="KWSEKDT"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF122">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN SKYWALKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="210"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="398" mass="47375" checksum="4D1F94003297069D" modified="2023-09-13" version="1">MDNNNQNENANQNQNQNENEKFRKKNFSIFVEKESNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILNSISKQDFDKLKQFDIFLPNSFLIDIERTIFEIQDQENQTRIKEKDKKIKRRDKRIKEKDKKIKSFESETQNLKNENEKKEKEVEDKNKEIEKMKPVFDKYQEQYQQYLEYELKKKLEEIKKNFPQFSNSKIIQDIEYVKKLQEWINDNKFFSKIKKGFSAKKDGFDSQKLHSKCDNKGKTLVIIKTKDNFIFGGFTQVGFTNDKSKWSEKDTKYDWGFIPDSNAFIFSLRNDKGDRKPEKFTIKQGEEKYAIFYHLNYGPTFGGIDISLYSSLQSGYSNFGQSYNLPNGIKEETDEVQSYLAGSWNKWEVDELESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCR9</accession>
    <name>A0A9Q0LCR9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1327" mass="150415" checksum="C0DB77DBDD7FFD8D" modified="2023-09-13" version="1">MKNKCSKFWKKVFKWIGKPQFLDFVGDDVIWRTMTILFLASFFIFTFGIAIRYLLEGLDLREDKIATNLAFFKFPNETEVFYGQPISAKLRVSKKFKSDGIFDCAVSVQASSFDSVEKESDFTLLELREKIKSDPQLFGGLTQYSDQDGIVKFSDISIISGSSNTVKLTFSSNCNWKNELDLSGPNRKINLGYDSKATEIEFPVTMKSKIQNFYLLNNDSINKGTFDYGEEILLVMNITNKEEFLNSELEGVRFSFVPGNRSLVYAEYEAYAVYELVDYSLDENGLANNTIKFLGSTSTQMRFTSFAQGVQLSYEDPLGNDVEGYFELNFTTKVKSVGISQNGSLSVKEGEKFSTPWIISVKDENDFPIPNKPVFVKLSKDCNTEVSEDQEPFIDEKSLYNSLVFTDESGNAVFTDLKFSIYGFTTSSCRFQIKFISDGVSVVTDDIQVNSSISKIVWTNKMTNLTILYTSQMNADFWPVIQVQDELGKGIANKLVYLVISNFTLSPSYFQTDQNGFALIHTDIAQMGLVEGLSEQTYYVSGEILNLDIVIQDFYGDIIEDDFYVSAFIAIQDVALDYLIIPEEGYWQISNGSGTISTRIFGKEMQSVIFLVASRYEIPDVNHSECWNYFRFVLANDVEEVEISYSPDVDNYFIPHQSFGNESIRVKVSGNNLTGTDVTVHVAALNAWDPYFDIFGLNSSYRARNLTNVLFESNYTLDGNNELILDDFVINDQTNYGIDFQHEPFDLLVFVNGIPATSEIFINLKFSNQSLHLNVTWDTSESFTSGYNRVTHQPTMRITDDLGDPVEGYYGYFWIANGFLSWPFDYVHTYDAQDPVVRSVAPSDENGTVTWNLSFQYVRNTQETYAYVYVWQEGYYGTQVVYFNVTEEFPLLQYFNFPEKVFINQDFPTSPTILVYDYYTSQPIVNKYVNLLSWNDSTYSFDYKGYEITNQNGIVQFSLNSTGYEDQGFMFIKFEVDYQNSLNFSIKVITFPTHILIASQPINGSQIGYPFLFPTETLDVDGSLVMGSVVVQLFAYSNLVEGKILSAEIEENAGNGVLDPETTSAITDQNGVALFNLKMISGNSGYYTIKFSYNNITMATDPFYLQNPIDSVTSQVYDFRDNIQIGDKFSATVTVNFNEGYQEGINFPITIITKCCNVSIPESSISISSEGFAYFQNIQFDSISGTSDCLIQTNKENKVKGEVSFSILGIQSDYHTFLITSPDSVVLTKAVDSLKQSVLFWVVCLSLAVPFFLNSLKKHNIVTFVVALALMIILMCFLPQLIPKAKKVESRQYISLSFFEGILVFFCSFAFIHSFIITNYPKISHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCV1</accession>
    <name>A0A9Q0LCV1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="6">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="6"/>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCV1"/>
    <dbReference type="OMA" id="CFDNEIA"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19504">
        <property type="entry name" value="RecA-like_NSF-SEC18_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000115">
        <property type="entry name" value="N-ethylmaleimide-sensitive fusion protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="261"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="541"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="745" mass="84037" checksum="ED9F70E4D60CEC02" modified="2023-09-13" version="1">MFLKPTNSPDTEHTLTNKVFVSQDDYYQIISDQNKEPHHYAMINGHFIYNISPSPKISKGQVALSNIQRMTCSIGYSDMVELKQFFIPEEDFYISDLTLEMGLAVKNPVAKKTKIDSGKLCEKIIRTLNNQVLTLKQKFVIDYEVLFLKCLVKDVKVVSLSEMMGESSEISEISVKEDKDNPQFRGLLTSQTQIFFEKTGESEITISGQSNRTRTSIFRPDWNFESMGIGGLDKEFSDIFRRAFASRVFPPSVIRKLGVSHVRGILLWGPPGTGKTLMARQIGKMLNGKEPKVVNGPEILNKYVGQSEENIRKLFEDAEKEQLERGDESDLHIIIFDEIDAICRKRGTRNDGTGVGDTVVNQLLAKIDGVDSLNNILVIGMTNRKDMIDEALLRPGRLEVQMEINLPNEYGRIQIFRIHTSKMQKEKMLAKDVNLEELAKLTKNFSGAEIEGLVKSATSFALNRRIDPDNLSKPVSVEGIQVTRDDFLTALREVKPAFGVEEDQFEPCLRNGIINYGSRFDKLYEIGMSYLQQVSVSERTPLISVLVKGAAGTGKTAFAAKLSMDSKFPFVKMISADSMIGMSEIGKCNQIGKVFDDAYRSPFSIIVIDDIERIFDFVPIGPRFSNSVLQTLLVMLKKIPPVNRKLLVFATTSSPDVLQEVGFESVFSAHITVPQLVGFNEISSVLLKLNVFNDKELKDNFSRLDDKTIGIKQLIMVIEMYQQIKKKKGSNFDSFLQCWEDFILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDB3</accession>
    <name>A0A9Q0LDB3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras and ef-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDB3"/>
    <dbReference type="OMA" id="RMLYTET"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="23104" checksum="77DDB7F48FD6ABF4" modified="2023-09-13" version="1">MSIPKPTDSITKIVLIGDSVVGKTCILKQFCDNDFDPDVPNTIGVDFRFQTIKIKGKTTQLQIWDTAGQEVFRSITHNYYRNADGVIVVYDITNENSFKCVEEWFDNLAEKAPQKAKRMLMGNKKDLAFKRVVNEKSGRKLANQYGALFFEVSAKSGENIFDAFQTLATEILKDHQVVEEKPQTVPVSTPKKKKTKKQNSQGCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDB8</accession>
    <name>A0A9Q0LDB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase cyp63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDB8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1253" mass="147042" checksum="C422F5761FBB9AD5" modified="2023-09-13" version="1">MNFLSNTPTYLLIFPRSYEYVFHSISDFSFQHFKKELNEVILNFKKGENSLQFSSISILLEHSKAILRHLLTFEEENFFLNEIIPSILLILNENKFLSNLSQETCEIINKFYQNLINLVLDRIEKDETVYFYQLLSRILNTDSYKWNQKNNQFKDSIYLEKVELLQILNDFEIVSKINSNNLKDSNNLKDSNNLKDLKDSKDLKNSKDLNNLNNLKDSKDSKNNSNNLKDSKDSKDSKDLNNSKDLKDLKDSKNNSKDLKDLKDLKDLKDLNNSKDSKNLKYSKNNSNNSKNLNENDSFVLLNDNLKYSKDSNNLKDLNNLKDSKDLKNLKNLKDSKDSKDSKDLKDSKYSKYSKDSKNLKNLKDLKDLKDLKENDSNSDDSDGFVLINDNSKDLKDLKENDSNSDDSDDFVLINDNGNNPTIYGNPPKPLSIYYHLEQDIVSPKIYFLENIQFFGNHWGFELLERILCDPNYEITISQLSYLIQLISKITESIATNLYPIITKFIEGSVNHLKRIWETENFESNASDLTSKILDNIKLTLLAYGNYPQTMSKIIKYTLDLAETLYKRENVSEAQMTAFVLIQYSINQNKAFATNYPLEKTHSNKISLFIVNWIKSTSFLFKFYSRNLTAKDVNLIEMSGHILSYILSIDIDLKILDILWLKATQQNFEDILIKQTLFKTIILLIKHDQPDILQNLSDKFDSIADLSVVDEFVFEALECLISKAIRNSKLCGERILWNILSNSKNLPNNLITKARELFQKSIRESDSFRLFFEEKSVVNISQNLNVNFAIYTLHTIFSVYNTSNLQFNIRQRIQFLDKKYSLFDLLIQDLENCVSHKSNPKQLQDEKRKMLLQIKHIKNLQIKIRFIFNLILHLSSSEQNKFFCKTCKIMINNIISDYERNAFFEILKEWFLNKSLSQIFLSKQFIKCIILLFKNSDLSKTTFVQSQVFIIIFILKNFANYQKFLDYFDQELYLKHPTNSAKFACADLLWQISLQARKKDTNKFIRKILTKCHLNNSTNGIENFIETSYDFLSNFLNSYLSNPNSKSSQDLLFKISRILSIITNFIHQYDKQFKHLVDYKSPHVSFKKRIDFKICSYIITEQDKKPEAIQVLSNLTLYYFFVFLSKKFHLKVRYFSLSVSGYEITFQEDSTLNQPIYSLYISNKCLFDTNEINIKTFDSNFGLYRVSKIQKDLEFNFSDRFPVQLLLKKKIFPNLIKILNLEKIVAKKAWKLIQELPLCKNLVIYFLKKISWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDV0</accession>
    <name>A0A9Q0LDV0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Colon cancer-associated protein mic1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDV0"/>
    <dbReference type="OMA" id="SDCQRED"/>
    <dbReference type="OrthoDB" id="26384at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009755">
        <property type="entry name" value="RMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049040">
        <property type="entry name" value="RMC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07035">
        <property type="entry name" value="RMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21029">
        <property type="entry name" value="RMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator of MON1-CCZ1 complex N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Mic1" evidence="2">
        <location>
            <begin position="506"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="771" mass="91677" checksum="C9AD7936DA074D1B" modified="2023-09-13" version="1">MENSEFLVELMNPIHFIPSEYDFVFFDETLQEIILLSKNIIYCVSLDHKITEIKIPKIGIENQNISQIKLSPNKKFFAIIQKNDPRFYIFSVKNENENENENSIQIKYLPKKYKDKHFVPISFEWLDSNEILFITTFSLEHHHLDLKKKTVQKIGAYSFVFIHCYLYQPQHKIILLCTDLNYINIRGFQFRINEIIQIPKFQLDIPVKEMYSKIKTNSNQGKESIEYKIRSNQNNITKSISIIQLYNKLYCTHIMIDESIRELRLYRLSKHTPHRDVLRLPKIGSGFSVNVVDNLLLIHNSEIQLSILYDFGPHKNGNLSFAFSIKPFVPFEEKIFIVENGINLKKILGNNENQNQNQNQNENQNQIQNQIQNQIQNENENENQNQNENQNQIQNQNQNQIQYQNQNQNQNQNQNENENQIQIQNQFKYENQIQNQNQFKNENQNQFKNIIQFKNTIDLYKPEWKHYQPNFVFDPKDGFLFHFELDLKSVALCVENLSQFEFLLRRSNCKNVALDVIKEIIAQYKNISIINWIFDLLNKNYSLALSKATETSLTGLSSQKSQIFQLQNPKNWNQQNIKRIQKTVSPNNPKSFVVIDQEDIYYEVFEKLHKNKIVDEKFLIVVITEYIRSLTSYNIEVSLMICNRLIDLFVISNQLHKLFQFIQHRVFKDSFEIANKLIGMQAIDPKCRNFGIDILKRLDNKQEMFDIFLSYGMLNQIMKHFTQDELVVFFDEDKLKIFKSKLLKSNNDLQIFTISKVFSELFKEKYDNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE49</accession>
    <name>A0A9Q0LE49_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tobamovirus multiplication protein 1-like isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE49"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="7">
        <location>
            <begin position="8"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="263" mass="30781" checksum="89F644939001CC9E" modified="2023-09-13" version="1">MTDSKNVLFGFLMFFFIFLFVIAIWKLTLLFLRTPQLYHQKIFFFLISIGSCGRIVCFFFQTFFWDFYSDNSKNTFNPLMAFFSDFFLSAFFTLIFTLAQVNFQVKNFSPLDAKHQLRNFIIVFTLTNVVVYAVHIPLIATHTDKLNFFLVSMYSICAIGLLGYSSLLLSSFYKKRPMANVMIIKKIFYVLLASTICYILRIPILIIGNLNSDDISDNQYALISFFYYLICEILPLCLIIFVLFVSPPKRNKYEITENNTMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEE6</accession>
    <name>A0A9Q0LEE6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEE6"/>
    <dbReference type="OMA" id="CCESASI"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="486" mass="56627" checksum="EC6180309819A021" modified="2023-09-13" version="1">MNSRKNKTNENKSQLFSVTHQHQHQQILPKEKIVFRTRKQISKQTNRNITPLHVACRNCHSLEVINLLIEKGADISAKSSHNETPLHYACQFQKENSVNVIKLLIESGAGINAVDDLHKTPLHYACQFQYKNSFNVIKLLIEKGADVNAKTYLREIPLHFACQFQNKTNFLGIVKLLIQYGSNATANAKTKLNKTPLHYVCQYQKENLDSVEEVLNFLLSKGAYLNAKNNENKIPLHYACECRNINAFTAIKVLVENGSDINAKTKDNQTPLHLLIRSKMKKRNQNQNQQENLNQNLNLNQNINQNQNINQNQNLNQNQNLNQNQNQNQNQNQNLNQNQNQNQNQNQNQNLNQNINQNQNQNQNQNQNQNQNQNQNQNQNINQNQNQNQNINQNQNINQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNLNQNQNINQNQNINQNQNINQNQNQNQNINQNQNQNQNQNQNQNQIKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEH4</accession>
    <name>A0A9Q0LEH4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von willebrand factor a domain-containing protein 5a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEH4"/>
    <dbReference type="OMA" id="QCSPMPM"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="268"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="814" mass="93496" checksum="B74D2292438BCB38" modified="2023-09-13" version="1">MSRIGLFNKSNNSQIPLKKVKFQTNIIDFAAKVSVDQVFENEEKFPIETVFVFPLNSNSAIFGFEILINNEKIIGKVKEKEKAQQIYNDSISKGKTAFKLDQETPDIFVTNVGNLAPKQSCTITILYVTTLYENEKNQYGLFLPTSITKCYVPLSDQERAQNLNSQTLQYSTDIGVDIEFSFRIKMSSRIVSITSITHSLPNQINIEKNESNFLFSPQKKEIGKDFLISIQEETPHAPRVISEVDETEEIVSMITMYPQLPKDKLNTELIFLVDRSGSMSGKSIDYVKSTLEQFLQIIPKSSYFNIVGFGSSFVYLFPKSRKYSSESIKEAGDHVSQMSANLGGTELKEPLKSIFENEPPVGFSRQIFLLTDGAVSNTEEIISLVKSESKTTRIFTFGIGHGASKELIENIAKITNANFEMILDHSSIQSQVMKQFERSLQPSITNLNISWEGVSAKHITPYYLPPIFSNQRYLFFAFISNQKEKVEKATVIISGQILDEKVEWKLDFNPQNLQRDSTLHKLAAKSMIKDLEQKSSSFHTKMGKLKKGLRKEAVEQEILRLSLKNQIVSSQTSFVSYVQDPLNLNHFQEMKFVPIEIQSPTQSSPKKNTRKSSFNNFSCFAQRVTRSEFSQKEDFQEDQKNFHKMEKEVHQVLHEIYQEMGKDSPVEIYKRMNEREEQKDVEITEVFKQKILEKHLESLEKIKNENFQIPKIVLNVGSFDIISSSQTQEGNWEISQELCSAVGISQEVIENSNPFISFSLKTWFNILIISLIQVCFPKFIQISKKAEEWLKKEEIQNIDLIIEETKRRIFIRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEL4</accession>
    <name>A0A9Q0LEL4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEL4"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042846">
        <property type="entry name" value="BTBD19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46965">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46965:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="307"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="485" mass="57355" checksum="88FD28A22B107AAD" modified="2023-09-13" version="1">METINKTFSNTEKLSQDLENLITQNNNEDNYSDFEIICYSSNQNQFSFNCHKSILSSRSQYFKSMFHSKMKEYQENKIIFQDVSKEAFSIVLQYLYTGKCNLNLENAVEILIFSSKYLIEELTSFASDFIKENFQIEILSDILKISETMNIKDLNYFCYQFISEHFNSLLKIKFFEELEEYHLERILSSDDVIAKEFDIFQTIIKWGKSKLHIQKEKLNNIEREELKSKISKLINKIRFIEFSKKEIKQVSKMNIIEDEVLKKVFKLKKIQNSNFEEFDKLLLEYQEEYKKNNLLFFNLRFHLISNIIKDTSIFRLIRSWIQDNQFFTKMKLRFSAKKDGFSSKEFHKVCDDKGPTLIIVKSAKGYIMGGFTKVGFKSQNPGHVKDDSSFIFTIKNPKNSPPQKFPIIEERIEKAIYSNNDYGPYFGDFGYYGDLCVYSTLDNGRSNLGRVYQLPNGYTYKTDETRTFLAGEYVGWKIEDLEAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEX7</accession>
    <name>A0A9Q0LEX7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enolase-phosphatase e1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEX7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="371" mass="43805" checksum="A1578376135A35A8" modified="2023-09-13" version="1">MATDLIELIIDAIKWFKEQFDNKAKAGKIVIQVLGRIDRLTKNNTILISSNANNSTNRINKYAKKGVFARLTSSSGFLEDIEEQNNLLDQLEHDLNLEVTIKQRVELQEFKKTISSTQSPNQIIQPISQNIIPKDKNSKDNEKPKYQSSIINTIQKMFCLNDKRFTTVSDIFGEKAVKFFEIYDTDDNEFLDRNELYEAFKQILNVTFFLQFWLSYKKQEKDISNLSKHEMNNIEFQIKELINEQNIISKVHEIFQELPITKKEQEGIQIQIQNQNQNQNQNQNQNQNQNQNQNQNQIQNQNQNQNQNQNQNQNQNQNQIQNQNQNQNQNQNQIQINQIQNQNQNQNQNQIQNQNQNQIQNQIQNQIQIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF14</accession>
    <name>A0A9Q0LF14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF14"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="438"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="543" mass="63445" checksum="DF53B1ED041A880B" modified="2023-09-13" version="1">MNEVLFFGLNQEPILLKNEPEIITKPIQFKFENENENENENEKQIKQISSNFFSTIFLFKNGKAIEYLNENDLNQNPEKIQIEENIQKVTVGYKNEAILTIEGNVFAKGNDVNPNNPNEFINISSLIEDTNDRIIEDIVCSAFSIYLLTLNQNAYGIGSNDSDQLGIDSQTLKETEKPILMMKNVSKIFSGNTSNHVFFLNSNQELFVCGSNEFCELGLGESRKEYITKLTKIQNIPKGEIIDIQCGSCHSIMLIENQNQNPKRKLYSCGNFRYNGLGKKYGHTYEFTEIKSSLFENDNNILDFSVGYRHTLILTSNSKLIGFGYNLYEDLINLFQRKEFCDISFKTKNGEIISAHKLILKYRLNQNEIQNQIEKLQEIISTKSIKESNQIFEMIYSNNSKINPKLYFEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDNSNKVTDYSELSNKSFQLFEYWIYSNQIKDEIQITKEIIDEIEIGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF36</accession>
    <name>A0A9Q0LF36_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF36"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="17100" checksum="28A2DD875DEAEDCC" modified="2023-09-13" version="1">MIFDFKDPEFKLKRSKNRKAIQIVVPAYSLVFSLQNENEQEDFLKELQNSRSLLKVEISKCSNPKLEKTTTLIDYIDSYMVFTTENFEVYKFKIHPNSKLKKSQKSPLIQIELENNGIWVLKFTNFEQIQKFVAKLHEGGAYRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFE6</accession>
    <name>A0A9Q0LFE6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFE6"/>
    <dbReference type="OrthoDB" id="2160519at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="78"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="201" mass="24022" checksum="838B8A0109B266AC" modified="2023-09-13" version="1">MDMKFLIYGLLNKRNCKRTLKEDIIPNQISQKLNELLILINQEDEKELEEFIHKEKEKEKENSFIFQTRFNFKLHSSIIKEKEHIQKLKEWINDDEFFYKMKRGFSAKRDGFDCQKWHDEVDDKGKTLIVIKTEDNFVFGGFTQIGLSWGVYGYIQDPNAFLFSLRNNHNDRLPEKFPIKPRKAKDALLNHSLNGPNFLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFQ4</accession>
    <name>A0A9Q0LFQ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFQ4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="749" mass="88240" checksum="93F129ED738C913C" modified="2023-09-13" version="1">MTEQIVSEDFEWISSLIHENINLNLTEKKLWLRLCKAAQIFAPEILVNLSKSTEKNKHTFISVCEKMGVSKKMLTIKKRKDLIPLINALYEKLYMSHKIQTNIKLTAEILSSTFQKIGLAEIFIHNGTLTISSLSQSESEKCDLNIQIDAHKQNSNILRIIFPSGTYFIAKFPPKMADTFYQTFKAAQFIYSKGRMYPRKKFLPSNPLDDQFEEIEPDLQYQIQTRNKKTKDKKKPLKQPQKAANEQEEFSKTRDVELFNENKFRIDLIDQDQQYFKGLIHLQKNEMQIKLSRKIYHSKYNRLLRIYYDANTKTIFKILLNHHEFLVQFRNEILAHKFLICYQNFRNSYIREARTRINEKKSKSVSQLMNYKTTETDSTESRTDWDRSQNIQRNVTSQIIPSVNYTQQNEELNFDDFLPIQKEQLIQMEDESEKSENSFSSIPTDSERDSRDKSFSFPITILNNDFQPTEKARFIIKSGIASFQTSSKEIKRGLMKDIQLSHHPKNPLVSVIVFPKSNATLFSFETKEDEKVVISLFYYNQTYLLEKNFWSENPHKSPKISNFLVNVYSKNFEKLEQANLTIQENRVCLELSNESYFSSVQTVNWVSIPEHEGFAVLHLDSNQFIISFVNEDEEIKFIDQLPKVIKTEKKKKPKRSQNIPFFYVSIVDSNFKKVSDIQVIFEEDELTIIKKKKKIASTSYGESVLQVLSHPRFNWIVSLKFPGFDELISFESWSQKNQFLQRMEDKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG31</accession>
    <name>A0A9Q0LG31_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG31"/>
    <dbReference type="OMA" id="WIPEIHY"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="429" mass="50864" checksum="2D38EFFC16D28866" modified="2023-09-13" version="1">MKSIKCVLVGDGGIGKISFLISYTTNAFPGEYVPTVFDNYSANVMVDGEPINLGLWDTAGQQDYDRLRPLSYPQTDVFLICFSLISPSSFESVKDKWIPEIHYHCSNIPFILVGLKLDLRDDQETIMKLEEKGLSPISYQQGLGMAKEIKAVKYIECSALTQKNLKTVFDEAIRAVLYPIKLSKKEKKLKMKQEKLERDEELKKKKEEQKKLEKEEKNQKEELKKLEKEKKLKIKNRTKSKIPKEKYEIIQKLERKNQKKLKIPKIKYQKQNQKQYQNQNQNQNQNQNQNQNQNQYQNQNQNQNQNQNENQNQNQYQNENQNQNQNQNQNQNQNQYQYQNQNQNQYENENQNLNQNQNQYQNQNQNQNQNENQNQNQNQNQNQNQYQNQNQNQNENQNQNQNQNQNQIKIKTKSKSKSISKSKSKPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGF3</accession>
    <name>A0A9Q0LGF3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGF3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5072831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="80" mass="9594" checksum="466948CD5E66EEBD" modified="2023-09-13" version="1">MDRDSRFNNIHHRNNFLTNIITEEWKKSSLPNEELIDSLPLPEETLNPEFEFVDLSIDLFEQEDENKWGDLSLQNFLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHQ7</accession>
    <name>A0A9Q0LHQ7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHQ7"/>
    <dbReference type="OMA" id="QTKPENK"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="855"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1190" mass="139037" checksum="26E486DC61324F35" modified="2023-09-13" version="1">MNKNKNTNKLKKSKSQSQTRFRNRFRNRFRNRFRNAITFIPKSKSKSKSKSKSKSKSKSKSKNQNQNQIKKEELKPTNETNKKRKSNKKKGNKKEEQKQKSKNRNKKGEQKSKPKSNTNKSKKEEQKPKQKSNTNKSNKEEQKPKQNTNTNKSNKGEQKPKQKSNTNTKEQKPKNRNKKGEQKQKPKSNTNKSNKEEQKPKQKSKNRNKKGEQKSKSKSNTNKSNTKEQKPKSNTNKSKKEEQKPKQKPNTNTKEPKPKSNTNKSNKEEQKSKSNTNKSKKEEQKPKSKSNQSNKGEQKSKPKSNTNKSKKEEQKPKQKSKNRNKKGEQKPKSKSNTNKSNKEEQKSKSNTNKSNKGEQKPKPKSNTNKSNKEEQKQKPKSKNRNKKEEQKPKSNKKKGNKKEEQKPKSNTNKSKKGEQKQKPKSNTNKSKKEEQKPKSNTNKSNTKEQKSKSKNRNKKGEQKSKPKSNTNKSNTKEQKSNTKKQKSKPNTKKSKSNTKKPKSKSNTKKPKSKNRNKKEEQKPKSNKKKGNKKEEQKPKSNTNKSKKGEQKQKSKSNTNKSKKGEQKPKPKSNTNKSKKEEQKQKSKNRNKKGEQKPKPKSNTNKSNKEEQKQKQKSKNRNKKEEQKPKPNKKKGNKKEEQKPKSKPNTKKPKSNKKKGNKKEEQKPKPKSNTKKQKSKNRNKKKGNKKEEQKSKPKSKPKSNTNTNQKDKQELKSKTNQSNKEEPNKRESKLISKSLSISISRSNSQNIKPNNESNNSNPIQKITMVEKEYFGRIGDMGIKTAIIQKPIINITENIIYPPKITEEFCNQNGLCWHFFNKGFCFKNCKKRHPIEFIICPNLYTEKGYEIPNEIQNENQNENQNQIQDQIQFENQNENQNENQNQNENQIQNQNQNQNQNQNENQNQIENQNQDKDQIQDQNPNQNKDQIQDQNQIQDQIQNQNQNQIQDAIPIAKKISYLKILLKSPIKKSEITNCKKFKKKGICQKLDCKYQHRCGPKKRNKKKIKNKNKNKNKNKINNFVDNPRKYDNYKSIPHKYKLRNASKSEFLMIENIWNSQSEGTKPPKIKSIKIIENNFLETRFKYIEQKNNESTKFQGILWGFHGTKKDAVDSICKSGFDANHQNRNAFGKGTYFARNPNISVNYCDKTNQIFLVQVCFIEGKYIYVSNNQFYIVPDVELLRPFALIKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHW1</accession>
    <name>A0A9Q0LHW1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHW1"/>
    <dbReference type="OrthoDB" id="411646at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="187"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="334"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="590"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="695" mass="82210" checksum="6646784DD647F314" modified="2023-09-13" version="1">MKKIEKNTKIFSFCTKNSIKDFKSLVEKGADVNAKNTYKQTPLHIFCLNQNENSLEIIKYLVEKGADVNAKNIYNQTPLHYVCSNEKQTQEEILEIIKYLVEKGANVNAKNNNKETPLHILCLNQKNEKLFEITKYLVEKGANINERNDINETPLHYICKNQKNENLLEIIKYLVEKGANVNEKNNNKETPLHILCLNQKNEKLFEIIKYLVEKDANVNEKNDINETPLHYICKNQKNENLFEIIKYLVEKGANVNEKNNNKETSLHILCLNQNEKLFEIIKYLVEKGANVNEKNNNKETPLHYICKNQKNEKLFEIIKYLVEKDANVNEKNNNKETPLHILCLNQKNEKLFEITKYLVEKGANVNEKNIQNQTVLFFAIRSGYFNLVQFLLMNDANVFDLEIEHFAPQIGEFFHKVYSLNNDMNIFWKSKDNFSDIQITSNDFSRFSAHNLILLTRLNNNRLILQKFIRACQQKSKEIVQIALNFLYTGFPDFDNFIQRFNSLHHFCSQYQNLKINTYSSKISGNKFFQRKKEMQQLKEKKSKNNQEQQIVDDFFKEIGFDSKWIQSKKGRKGIIKDFQKLYQENESKKDFTIICQEENEEKEIKAHKLILAIRSELFKGMFLNVEDNSNKVHDYSGKSFETINQLIYFFYHDQFNQIKLDDEIIQEFEDVKDFYQLNQNSIIDLFLEEEILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI12</accession>
    <name>A0A9Q0LI12_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09266</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="32"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ENTH" evidence="11">
        <location>
            <begin position="810"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="515"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1087"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1193"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1317"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1193"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1222"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1243"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1321"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1346"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1367"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1392"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1441"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1481"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1509"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1534"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1588"/>
            <end position="1610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1655" mass="194255" checksum="3878AE870C23B1CE" modified="2023-09-13" version="1">MNFLKKIGLVSTTQTTSNPEIGKSIKIGKKNLKIDSLIAEGGFGFVYLAKDEETNEEFALKKMAVSNKEQLISIKREVKFQKKFIKHKNIVKLYDAISVKEDRGADFVYIMMEFCPGSLVSKMNSLLKQDKKFTEKEALKIFYDICKGVYYLHKSNPPVAHRDLKVENVLIGKDKIFKLCDFGSATQRVYTLKSQQERYEAEDDIQKNTTLSYRAPEMIDLFRKQKINEKVDIWALGCVLYKILFFEGPFEEGSELQILNENYEIPKSSYSKETISMIKWLLNSDPESRPDIFDVIEKVAKFLGVKPLKRPEKTQVVEKEKPIEEKINLPKKTNQKENKSKKEENNQPEEQNSFFAMLDWQPNESNQNQKPKPKPKIESNQNPKIESNQNQNQNQNQNQNQNQNSKRKSQNHKKHHHKHHHSKNSPQKENNEQLQQNQPQLNPVEKNDQPILIFDPQEFENQMKQYQDKKETIIDSTSEKNDQSEEKQVENKMINRNKRSFLDSDEFFFGEQNQNQNQNQNQNPISFQSDSENENENQNQNQNQNQNQNQNPISFQSDNENENENLFKNQNQNQNQNQNPILFQSDSENENENLFKNQNQNQSPISFQSDQESNKESQDENDENDENDEKGNDEQKKFSLQEILHDKKTNEQIKIQQNEMNQERIIVETKTEKSKPKPKRRHKHRDHKHGIKLEDQSQSISSDNLNEKLNEKLNEKLNENGNLNENENSKLNENENENENKKHHLLKEKRSKEKPIKTVAVKPEGNPNFKLSSQPHLKPITNQSSINIDNLKLEPSTEKTTKLSKFQDFAKATFSSRHNKWVIKAINSELSESKPKYVRKLILMTWKEPQNIQSFYQSIIKRPIGKDSIVGLKFAHLILKMIQEGSPAFLEYTKKRDDLFSKLLESWKKIQKGIFPVLLVKYLNILIEKIDFHKSRPEFEGNLSLGTYIINSFEKGIIDPLYDYEKCTGEDLVSEKTVKSLLSLYEKIIDYGKISFSNSFQNLEKLDSCQTSSLIPIIKEATNLFQIITNFTSKLISNGKLKTPSKEEIIKKYKSCFPILKEFVFQAKSIQMISSLITVTELPIREKKKKEEEERKKQLEEEEERKKQQQKLEEEERKKQLEEEEEKKRQLEEAEKNTQEIFFDIGNFNTNINDSNDNIIQENQNQNQNQNQNQNENQPKLFSQDFFDDNIFQQNQNQNPNQNQNPNQNQSQEILPGFENFGNDQKQTNQSFIGFDDDFDTFSSPKQQPKQQNQSIPKIQEKEKNTQEIFFDIGNFNTNINDSNNNIIQENENQNQNENQNENQNQPKLFSQDFFDDNIFQQNPNPNQNSNSNQSQEILPGFENFGNDQKQTNQSFIGFDDDFDTFSSPKQQPKQQNQSNQNLNFFDDNIFQQNPNQNSNQNQNQNQNQNQIQIQNQKKPKQTKQDFIGFDDDFDSFGSPKQKEKPKQEIKPKQEIKPKQIEKPKQEEKKSKQEEIEKTKAINQMEQLTNKVTKQVTNQQTIMNQNQDKKKHHHSREKKHHHSKTKPKPLPKTNQEKPKSNPKTNQEKPKSNPKTNQEKSKSNQEKPKSNPKTNQEKSKTNQEKPKSNPKSNPRKIQNQIQNQIQNQIQKQIKKNKSKTNQEKSKSNSKIKIKIKIKIKIKIQNQNQIKIKQKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIM4</accession>
    <name>A0A9Q0LIM4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIM4"/>
    <dbReference type="OMA" id="HEVRDFK"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="199" mass="22592" checksum="41FAFEF76D9A40EE" modified="2023-09-13" version="1">MGDELYKLVVIGGGSVGKSCLTVRYLQGKFIQDYDPTIEENYRKMVIVDDRPCMLEILDTAGQEEYRTVRDKYLKQGQGFLLCYSITSRASFSEAKKLHETLRIVKKTNKIPIVTVGNKTDLESDRLVSTEEGEQLAQEFSCEFIETSAKTGLNVTEAYESLVRAVRKWKIEQETSTTTVTTNGQKPQLKKKKKLCMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIX3</accession>
    <name>A0A9Q0LIX3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mtl1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIX3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="506" mass="60888" checksum="CC79667B1B93A51E" modified="2023-09-13" version="1">MLIYEKINQNKNQIENENENQNENENENENQNQNQNENENENQNENQNQNQNQNQNQNQNQNQNQNQNQNQKNDKYFRNSINVSDQKTLEKLFYQEYSNFIWELIKVDPSLVLRITHKDSSSFLISTVKLATLFVFKIKIFVQDEIYLKDWFNQLSQLYLNYKEASYWFFKILLEKKWIISITTEYTSNKIAKYFVNLVGNITSVILQEEREIYLNEKKDLEKSQKSILIECIDFLIENLEMVLSSNRNPKYYLKLISNFSVLGKEECRYLFQKGILKNLENFFLEKFQDKTFNQRTQPTFRFDKFESFKKEEKEEKIDPKNFSPILKIFYYVYSFCEITEINSSKKKEVELNEMILTVEEIKQEKRFFLLCISESVNRKMMKKIAHFFSIQNKILSSFFEEICFDLMNVAQKEEKLIPSIEILETLMIIEDQQQESRIWNILSKVSNLLKTRKKNNLETLIGSIEKIFTNLIQNNISILNLIKSNREIKKLFLIRQILQKNKNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ77</accession>
    <name>A0A9Q0LJ77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gtp-binding protein rho5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ77"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001179">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="600"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="322"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="808" mass="95036" checksum="B7AD3483A4177930" modified="2023-09-13" version="1">MENSIKCVFKGDGAVGKTCLLIASTTNAFPGEYIPTVYDNTTFEITEGGVTKTLGLWDTAGPSSDWDRLHLLVYPETKVLALCFSLVEHNSFENVKNKWIPEFESYCPLTPIVLIGTKMDLRTDEETVQRLRQSNLGPITTEQGKRLAKEIGAVSYIECSALTQQNLREVLVALLKASDVEIKKKESKKNKILRKMLVPKKESPKLPSKPPIPPFVSVPSTFSVDILSCFNDPTYSDVHFIVPDKDDSNNLVEKTIYCHSMIISTRSRIFNQIIRNFEIDTFRRKFAQYRIYKNEDRGDLISNQFFQMLGKGKVKPDEEVKITGKNENQNENENENENQNENQIQNQNENENQNQNENENENQNENQIENENQNQIQNQNENQNQNQNENQIENQIENQNENQNQIQNQNQIQIQNQNQIQIQNQNQIINENIKSNDENAELIKTISNQIHIQKIKSNQIQIQKTPKQLEYKPKNSLYKFYADFSYKPFFLFLLFLYSGTIPEELKPKKDDNNNNNNRKQNQEKEEKQKELVDQFYEILDIFKMNSVKPILDLIIPDKKNPRNSNDIIDNEIQAKNLIDEEIKKLRENIGKILLMRQDLSDFIIEVDDGKGRIQKIKAHKVILNQRSDYFKLMTESKMKEEKESRVVFKDMDYETVLRFITFLYCDELQIYGTILSDKKSRKYKKEISEFNRKLFELLVISDYFQCDKLKNLCEAKLIEKIPTFLLIDGLKISESVNARNLYNYCVWKMGIKYSKIHKMSNFKKQLTKEQRREIRKERWPPKEYEKYHSKFKVKLAKKFNLIEKEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ85</accession>
    <name>A0A9Q0LJ85_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hermansky-pudlak syndrome 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255480at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017216">
        <property type="entry name" value="HPS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28633:SF1">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28633">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="613"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1288" mass="149084" checksum="9E333E757AB652B5" modified="2023-09-13" version="1">MIPLDIFDHQHNLESQNEPKTICTSPFSNLVVVGTERNTIQINLVENKNSTIICTFITFGKIIALKLVYNLIISLEKERKTNYVRIYYGWHKLVEQKQTFYSDKILKPQKVEKKQLKEKHKEYEKLLICYTIPSSPTKEIISVCDFSGKLGFCQGNDIIIYKLFTNTAIATKLYSIRTGLNVQHLSISGKYIAYATDFIAKIIYVTFHKQIKTKYEVEKNAIEHFSPISTQNTYELKFDSENLVSDMIPDNWIQSDTSKEIPAYIRYGPLRDDSNFVIPENHCMNYENIQAFPFKQAHQEHPKTPRDAMYSGHKYKKLMSKLSSQSTFKVSADEQKKQLEIPTVYLLFQQRFPETKKQSVNNILLMNDYSATIFPDALANETQKKWEFPKQNEEFLVIQESTNQEFIHQKYLLETEQSRKLKCLICSGTDGYLYDISNPSLVCKFKFQNQALFACASNSFLFVMEANSLEILTIPPSKFNSKTDSKPKQVGLKHFFVDLSRSTSQNSLSSNQSSDSFISINVDDIKNDTNDQIISVTKKPQKNIDSNQKIKITQNHIWNIYVLHRTEIAQIYSEVHSILSQNELDQLKYSEILTANHFLLSGYYYELVEIAKMDSILGNLNLNENENENLDENQNENLEKNENEKSNLNIQINLIEDENQESKNNKNTKTTENLYVQGKYKDQIEKFNHLFQQSAGILGKIMLELKDYEICAQLFSISDIYFKDVFELFIAKKVPQEYFTVYLNVALFRFDMIDATRTINDLSDGEEDNIQEVIEKPGNLSNMILELYSELSPDMLPSIVLGSCLDDYDQSVAIDLLEKTFHKIQDANGYCNSENLIARGLLLLGNERVLDAIQLFESVPTSLFVEFCLENPALLYTDRNIFRNKIDEFAEIEDHEKNNENNNESQSESEQSVVSKEDVFEDSFIPQENAVPSLGSIMRKVMPHALVDVLVAIPDMVSIETALSLLSEDPIILGLKKPTTIHAIETKQLVQDYLENLLLRIVKVEKNNCLDPKNPIYDLIISYESLVQKSEFDVLIARLVSMYIQNILDSLNSTNFLSAKELVLNENDMKRKHAFLLFGERDSWIKKLEKFLLDQQNSKNEKTEKKLAENVLKLETILCKLPISKPNAEKTLQLVQNLGNFFPRICIEMICLPFAGKFKESIDLILEQKPWILFGYSEKSCENQFENWKVVLDQTFLKIDKIQKEIQKEVQQDVFLQKKNLLEILKKQLELIFSKILSVYNFHTILKLVPSNGNPLFFLPLIERSFFFQNSEKIVEEIIKESLFCHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK53</accession>
    <name>A0A9Q0LK53_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK53"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5072878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="123" mass="14316" checksum="C986D3C4A0314B6C" modified="2023-09-13" version="1">MNDCLFFGSNENPKLFKNKPDSITKPIQFKFENENENENEKQIKQISSHIFAIIFLFENGKAIEYLNRNDSNQNPEKIQIEENIQKVTVGYQNEAILTIEGNVFAKGKYINPKNPKNLSIFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK65</accession>
    <name>A0A9Q0LK65_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK65"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="157" mass="19064" checksum="411B46B637AE8438" modified="2023-09-13" version="1">MQENINKEIIFKDIKFESLLMILEYIYSNRFFPPSVELAIIEKNTTFICNSNKIILDLFILSDYFQMDRLKQLCEVNLSQTLSHEMLIPTLQIAKTYNSEFLLEFCYWEIGNNFINFQKRKDFKKLEKEDLVKIKKFQYPPQEYIDWQKKYGELNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN45</accession>
    <name>A0A9Q0LN45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN45"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="202"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="307" mass="36620" checksum="F0D1BC97EE663FBB" modified="2023-09-13" version="1">MWEFTEIKSSLFEENDNILEIYVGDYHNLILTSNSKLIAFGNNEFGQLGTGNTNKQYSPIQIKLPKLKFNENISNYHISCGYSNSFLYYSPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNM2</accession>
    <name>A0A9Q0LNM2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rrp15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNM2"/>
    <dbReference type="OMA" id="MQDERIT"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="235" mass="28149" checksum="FB845169F8F50E04" modified="2023-09-13" version="1">MNKKNKEIEEEKEIETENEFDEIKQIIKEAKQKRRKKKQKKKNFNKKKKQQNSTEKTNQFKTQILQILNEDIKKVDQPILSQNKTSSKKINQIEKQKKEKREEKLFKASQIENKNKQYKLPTNDEYDRKLNRIATIGVVRLFNAIQKQQSIPTENSDLDSKQLSKGKFLEMLKSQDVKVSKNQDQKNIQENSPQNNQKWEVFRDDFLLDAKMKDWDQKNENENENHDSISEESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNN1</accession>
    <name>A0A9Q0LNN1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNN1"/>
    <dbReference type="OrthoDB" id="298084at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="26"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="203"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="498" mass="58625" checksum="37F41AB42CEF6DD3" modified="2023-09-13" version="1">MENYSNLEKLSNDLKTLFENQEENYFDFEIICQQNEDSIPITFKTHKSILSSRSQYFKSLFNSKMKEFQENKVVLKDFSSSIISLILNYFYSGKIGINLENAIEILIFSTKYLIDELIEITLNFIQNNLQLEIVVDVLKFSESMNFNQLFDSAYQFLLANFHEFIKTPFFVELEENHLNSILSNDEIFINELEIFESLMKWGKHKVNLNQEKENQKLDKEEKEKLQKQISNVIDKIRFVDFSKEELENTLKEEEDLIPNDIKEKLIEFQKLENPEEFIEKESQNEKSFIFKSRIRIDSTIIKEIKDFRKLKEWINDNEFLSKMKKGFSTKRDGLNSKLWCQKVMEKGKVLVIAKTTDNFIFGGYTKAGWTEDRSKWSFDYGADGFIPDPDAFIFSLRNDKNDREPMKFPVKQEEVGYALYYDHLGSRPNFGRGELSPDLGNEYYPDFWFDRKFKGGGSNFGVSFELPDGIEKGTNEAKSYLAGSPKSWEVDELETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ94</accession>
    <name>A0A9Q0LQ94_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein diaphanous</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ94"/>
    <dbReference type="OMA" id="SLEFRMH"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="25"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="798"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1230"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="448"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1274" mass="144984" checksum="61B1C8A4627C8573" modified="2023-09-13" version="1">MGNCAAKPKTNLEKSTSIMALDELPPLPPPKELAEKFESFISQLNLPSEKIDGIRLLPDQNKWLLVCQKEHKDEIKEEKETPQHFISVLNGEYSKDDIVNLRVCLTNLEMDFVSQFIKGKGHEALLEVYQYEQQKAKATQESVAHAELIRSLKALMNNSIGLQAVLKTPNSINILINSVDSTNIKIRAFTLELLAAVTLVPPHGYQLVAAAMENFKKSRGKIIEEIIVKELFNGEKNGFAVVRICMLFINALLFQGDFDQRINYRFKFIQYGLNDLINKFSDNLLESDDELNRQITIFKDSRDEDNEKLMNGFGTFEVNVSDIREMISKLDVAIFNPIPEERITHFLQLITYLTHATHFDPQSVWKTFKSFLENSIELSSKTNDFRSLIAFGNELFDLQQKMQKSRDSEVSNQMNKTKIQELQRDLGDRGADAISSLDTIEKELVSSLTSIAEQKSKISEKLKQKQRKHELRTEELHKGLEKDIKRYKKEIVTLKKQMIDGINPNQAQKLAPSKRSKSHRAHRNNNNNNQNEIELDIEDESEDFKLKSDSQANTYEDTTWIDQDQTYEVATDLSEDEFEAQLKKDFIEKHKPEIESQFKNEFFEQHKEEIEKKLVEEIEINNQKISQQITKQKTIIEEEKKKKETESEGLSKTITNLKEKLEEKKSSIEKLKNDLKKLQENMSIDEIEEKVNENSGGPPPPTGGPPPPMGGPPPPMGGPPPPMGGPPPPMGGPPPPMGGPPPPMGGPPPPMGGPPPPMGGPPPPMGGPPPPMGGPPPPMGAGPPPPMGGPPIPMGPPKKKSVKPKQPMKNLHWDKIPPIKIDNTLWKDLDEDEIEFQEDDFVESFAKKIIPPPNPKENNGNGGDVVVEQPKKQKIQLIDGKKSTNIALVLPSFKMSNEEIKIAIFEVDENKLTEHNISTLQSSIPTDEEMESLKNFEGDKNDLFESEQFLLEIIQVPRLKQRIESMFFKKQFPQLMEDIVPNINALKNATEQLKTSKNFQRFLEIILAFGNFMNGGSRQGGAYGFRLDTLLKLKDTKGTSNPRINLLHWIVDFIENKEPDVIKFPEELKDSENASKVSLDDLRSNITEVSKHLSALEKELPFHEEPANENDKFGEKMREFFDDAKNQFDKIQDDFQNAQTQYEEILSHFGETNPKTKPEEFYGNLFRFIQDFLTAIKDNKQRKEQQERELKKQQNKGRRAKKGGAHQNKEISQDEKGVMDSIIADMRNGTAFKISRESTTRKISKLKQTERQPPPPQIADFRMHLKKVNRNNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRC5</accession>
    <name>A0A9Q0LRC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thyroid hormone up-regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PAAF1/RPN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRC5"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF19">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT RPN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="474" mass="53759" checksum="5E03873D24E919F0" modified="2023-09-13" version="1">MSIRLQSDWNKGNSFWVQCSKLNGTQTIYSELKLNENQEYQDLKGIFTTEKIGNKKNLLKIKCKESKYESETTFQGAIKEYGKVHGTEPKKQAILSIDISPQSQLTVSGSTNGSLKVFETETGEIRRDLVGHIMGVSVAKFFPSGQVVLSGGEDFRLRIWDISDGECEAVFVGHKSRVNAAAFIERGRNILSTSNDGSSRLWNSGTEQQIALFSRNNFFNQNSPFANFDVRNFDCCVSHLDAQKYPSLFRYNSNLVLDQNEFGTDGKILFVSSNKGNVDVFDVRNKKEIWNLMLTSEDFKNQNQNLEKLEMDCVNYDMNCVNFLPDSFTVVSGCENKLVQWDLRTGRILSIDYVGSLGNLQSIKPVIFSNPNLKEKEKGNEKEKEKEKENENEKNCQNNSQNSQNGENIQNNQTGLWISSSDGECFLWDLVNKKRIFSLSGADYDSINSFAFNQNKIVTGSKDGFIRIYNTKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS01</accession>
    <name>A0A9Q0LS01_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A-type inclusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS01"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="358" mass="40620" checksum="99F9331D25E8C547" modified="2023-09-13" version="1">MGNVNSAKKKILKKQTKEYKKKIAQFSEAITHSDEKGNFLYVNKAAVKMFKAKSKNEILSRNAGSLAAAYQPAFKMPTYQAIGVIGKNIFESPDGFYDFDFLHIDLDGKEFWCHVWLTPINLGGKMVLQGYTRPVSEPGITKTLDLSQEAAFFVKPVSEKQSKSNSKSSNSKTETDSQTDSFVGDGLKSTTELSDTENPVNFSEKTKTESIQKTKDLQDRIESLTTSSHSSIILFDNDENEVQLQNRIDKIKSTVRSHDNPVLEKTVVEELNEIKKIFSNSTQTFQKQISQLAEKLQKERNQNQEKYSQLESHLQKSLAKTQEAQNGYETLVNKMKIIEEVFDNKLNQILHPKSEKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS79</accession>
    <name>A0A9Q0LS79_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS79"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="336"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="434" mass="49633" checksum="CC0EE6C9FB8B77DC" modified="2023-09-13" version="1">MSSLLFKKIEENNYEGVLEALETESLRTRSEKKTKQKQGLSPLHAAILFHTNLDIVKLLVEKGADINEKSGYSPLHYAMEGYSSDDISAFLILKGADVNIKMNYTPFHFACIHQASPKIIKLFIEAGAEINLPANNTPLHYACIYKSGFEVVKLLIENGANIHAKTKLTPLHCACQYKNDPKIVHLLIELGADFLARTKGLLPINLTTNPEIHKLFLQQKCILEEMKNLFEQQELTDLTIQCSDGKIGIIQCLIQKKIGGVQELFRIINFFKFKKVELAKIFFSFLYSGIIEEKNRGILKEQVKELGLAKDWIKRNKGRNGVIPNLQELYFEDETKDFVIVVEEKKFKVHKFILFARTGLFRGMFLSVDDKSNSVSDYLGSSSDAISSFLKFLYFDKLDESLSSEIINELENFIEYYQMNENSLLFDNLKKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSX3</accession>
    <name>A0A9Q0LSX3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gem-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSX3"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="258" mass="30300" checksum="ECF82BA69FFC78B4" modified="2023-09-13" version="1">MNPKETIPFFIPSISNSIISNSIPINAEEYLISVRNEANRLPNILQNPYNLDPNRSQKKRQKNNDNKIDDNKRTRKNKEHINSNKIDDLKPDDSFKIPSKKWEENLTLNFNFLQNQIQNSQQNSIVQIPTKLKTQEWLEFLKSTPPQIQILQQFDHVIITRLLKLLINKFSKTTKLIKKNKENKEENIKLIIDILSPWIFALFATIDLPLEPDTCSNFRDLLRICLDSRKINEEINLIASFNILITIITKIFKQGFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTF9</accession>
    <name>A0A9Q0LTF9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000049">
        <property type="protein sequence ID" value="KAJ5078692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTF9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="76" mass="9081" checksum="351C5C7CFDFBFB3F" modified="2023-09-13" version="1">MKKKKNRKKQALNKFTSVKAKIKENIYGMLVWILEEIELLCKKYYSSESLNLLIDNLKKYSKIESKRCSKFGEIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTJ9</accession>
    <name>A0A9Q0LTJ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_05077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTJ9"/>
    <dbReference type="OrthoDB" id="2311693at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="189"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="474"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="426"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5078289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="650" mass="77519" checksum="629562E9851FA90B" modified="2023-09-13" version="1">MNSTRNTDSDEKKHLKRNSNSNSNEKSKEKPKEKSKEKSKEKPKEKSKEKSKEKSKEKSNQKSKEKSKEKSKEKSNEKSNQKSNKSNNSNEKSNQKSNKSNNSNEKSKEKSNEKSNKKSKEKSKSNEKSNEKSKEKSNEKPNKNSNEKSNQKSNQKYIKSRKEKEKEKHSKKMLHEDFLNCYTSFNHLTNFTIFIKNSENPPIEFKTHKIILSTRSPFFHKYFCVRHCPEIYFENINPEMMKLVLDYIYLGKLFHKQQKKEDLISLLKMSIHLELDFFVNYVTKKITKSLDQQNIFYFFKNNEIVKSSKIESKCLHFIHSHFSQFDKQSFSNLEEHQICQIIQSKIDTDKYLPINYFQMIESWHKSKLKTEMQIIQKNRLNRIINGLFQNFSPKLVDKQFIEDLRSFTFLSDFFLRFDQFEVEEKNKKLQDQIDIQDKEMEKQKKNYIKNQQKYEKEANEMQRKINFNLMDTFLLENFEYIQILKKWINDDNFFSKMQLGFSAKRDGFSSKNFHDFCDNKGKTLVIIQSKNNFIFGGFTEVGWISGENNRGIKDLNAFLFSLKNPEQTSPQKFPFKREAENEFALQYNLEWGPYFGNSDLAIISSNLKNGSSIYFGQSYVLPEKIDFKTKQSRNYFEKLKKFFVFHLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTS5</accession>
    <name>A0A9Q0LTS5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinitis pigmentosa gtpase regulator a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTS5"/>
    <dbReference type="OMA" id="HHSNDHK"/>
    <dbReference type="OrthoDB" id="348671at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="449"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="669" mass="80654" checksum="996C4B37F95ADDA1" modified="2023-09-13" version="1">MQNQIPFQYPSPFQNPNQNPNQNPNQNQNPNQNLNQNPNQNPSPNPDQNQNQNQNQNPNQNQNNQNNQNQNQNQNQNQFQNPNPYQNQNQNNQNNQNPNQFQNQNQFQFQNPNPYQNQNQNNQNNQNQNQFQNPNPYQNQNQNNQNNQNPNQFQNPNPYQNPNQFQNQNQFQNPNQNPNQNPNQFQNPNQNQFQNQNQFQNPNPFQNYYQNSTICPNLLKDKWCHGWDHVKHKDPILHPPEMILCFNILRHGKCNDINCPYQHVNPINKFYQKIMDIADPQRQYRDRNKPKNSFFLCELKMKNTVCPRTTTRTTNSNQFNKPIQKPIQKPIQQPIQKPIQQLFNQQKPIPFENSQICPDLFNPKKKTVRKCTDPNCKFAHPNPNLLKSKKNIDLNFLTSMNRQVCINFNKDGCTHKKCTYQHITIKNKKELDKLISQQNQQNPNNQFENQMNQNQNNQFQNQVNQLNQLQNQMNQNQNQLNQLQNQMNQNNQMNQNNQYQNQMNQMNQMNQMNQMNQMNQYQNQMNQNNQYQNQMNQNQMNQNQMNQNQMNQNQKENKHKHHSNDHKKDKHKHSRDHKKDKPKHKHHSNDHKKDKPKHKHSHDHKIKEKENEHKHSHSHKSKEKEKKHKHHSNDHKKDKPKHKHSHNHKSKEKENEKKHKHHSHGHKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTX1</accession>
    <name>A0A9Q0LTX1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras guanine nucleotide exchange factor c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTX1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="200" mass="23913" checksum="546C32BB15408B7B" modified="2023-09-13" version="1">MQENKQSQEIKENLNEERICVECKTQESGIWTKINIKPPTFLCQTCYYKYRTKQILQSPKNSNLKLNKNSFQEYESKQIKSKESNGNENENENENENENENENENENENENENGNVIEIENKIEIENINQNQNQNQNQNQNQNQNINQNQKNQNQNQNQNKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU13</accession>
    <name>A0A9Q0LU13_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Btb (Poz) domain-containing 2a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04854</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU13"/>
    <dbReference type="OrthoDB" id="7873042at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="606"/>
            <end position="660"/>
        </location>
    </feature>
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            <begin position="271"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5078529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="664" mass="78368" checksum="238DBF7FD04EB60C" modified="2023-09-13" version="1">MDKTQKKYLYKKINFSFIQTSKNSFESSIKFPDTIIYCGSNKTQFKCHKSILSSHSNYFDLAFKENSFNKVFFPNISKQTMKGILDFIYTSELDFSGLSPLEIWKTSQMFKLDELTQITEDEMSQNLNQDFVFVILQETRKKEKSNLELECYEWIEDHFQDFLESQKIHLLSSKQLMDVIEIRIKYHSEMDLETVFLLLNNWKKSRKSSNQGLSEFRQLKTSSRFKEIVTSLANDFFQKKKNPKILGSDFFDLIPQEILLKAECGIQIGAKRNKVENREEAKKEFQKLKQIRILSRKSAKSNLEIKSLLDSNEKYLNQIENLKKEKKQMKEKITNLGSKFEIEKENLQKQNQNLFQKVGLLEDSLNENKKEKEKLKKRCSQYQSTINSNESRYQDLKQRLLDTKSKFEIEKENLQKQNQNLFQKVGLLEDSLNENKKEKEELKKRCSQYQSTINSNESRYQDLKQKFINLEMEMKQRKEEKVKENFIDKETKTELNHQLAIIAQNGDLSKVMNCIKQGADPHYESQKGIKLMHFFAMKASVSDFKSFLQKTQTTLDNSKTNFGWSIFHFAAHGGNKELYRWLKKKLRKDPKIVNVGLSFTPFGLRLSGFYCDKCHASPIIGTRYHCLICENFDLCEFCKDSQFGRHRITHPLEKNEPQTEFNCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUA8</accession>
    <name>A0A9Q0LUA8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="2">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_05302</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUA8"/>
    <dbReference type="OMA" id="IMFASIN"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="14">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5078045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="299" mass="32878" checksum="2A27C180F3E5A69B" modified="2023-09-13" version="1">MSQEFIEAEMRLFAQQSKEVDIIITTAQIPGKRAPLLIKREHVELMKEGSVVVDMAADSGGNCEVTQKGQIINYKGVTVIGVTDLPSRMAAQSSQMYGTNLLNLMDEMKRAKDFVVDLNNEIITGMCVTYQGEAKWPPPKKDPPKQAPPPNQAPKPQILKPVEVAAPKKRRSLGARITIGVILWIIGLAIFCVFGLWGPETFLTHLSIFVLSCIVGWTVIWNVTPALHTPLLSVTNAISGIVILGGMTLISHGSWKNTTTFFAAFSIMFASINAAGGFLVTYKMLRMFKREDETTGRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVA4</accession>
    <name>A0A9Q0LVA4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000004">
        <property type="protein sequence ID" value="KAJ5080676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVA4"/>
    <dbReference type="OMA" id="SLMEIAC"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="401"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="4">
        <location>
            <begin position="410"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="445"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="532"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="575"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="651"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="656"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5080676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="768" mass="88618" checksum="8AB8DA766D2DBA90" modified="2023-09-13" version="1">MMKTKNKMKIIQNQNQIQKSNSKSKSIHKHHKHHKHHKHHKHHKHHKHHKHHNNHNNHNNQNQNNENNENHENNENQIQNNENQNNNNNENNQIQNHENQNHENNENQNQNQNENNQIQNNENNENNENLNQIQNNQNQNNENQNQNQNEIEEMKNRIKLKKNKYLEKIEKKIQEMKIQIEKLNEIEIEKIIQEFKNEIELKKIEYFKQIDEEIKNIQKKIDEEKSKIKILQSPEKAIIFLQELSNSIQQHDKTKTQELIGIDVPFIAECMNNFRTNEGIQQNGCSILQKFAKENEDNPMEIKKINAIEPLINSMNNFPNNEDIQIKSSEALLIFSGGLKSEEIENRKLKGTEISNLKGIEPIINAMDKFPDNQIIQEKSISILINIALNSKNQNEIKKLNGIEPIIKAMDKFSNNQDIQYKASGALLNIAVRNKENQNQIRELKGIEPIIKAMNNYSNNEAIQENGCLALWSIAANTENKVEIRNLKGIEPIIKTMNNFPNNQLIQFNGCWALLNIAVKDKENKVEIRKLNGIEPIIKAMNKFPDNEDIQENGCGALWNISKDDENQIEIRKLNGIEPIIKAMNKFPDNQIIQVNGCGALLNIAGNDENQIEIKKLNGIEPIINAMDKFPDNQGIQYNGCWALLNIAANNGIEPIIKAMNKFPDNKDIQGNGCGALLNIAKNDENQIEIKKLNGIEPIIKAMDKFSKNEIIQVNGCGALLNIAEIENQIEIKNLKGIEVIKKAMENFPENQLIQERGKLILVKLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW49</accession>
    <name>A0A9Q0LW49_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW49"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13136" checksum="FBBD86607119A6A7" modified="2023-09-13" version="1">MFQKDFSKNFKLKLNINDIDVFSNFILFLAILNKFNLKFRNLILFLEGREQGRRNRIWNRERNPLCLYSYCFTASLPLALCLCLALYFQNCIAAFAQNFCRRLLAQASATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW75</accession>
    <name>A0A9Q0LW75_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inner centromere protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_03677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW75"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="8">
        <location>
            <begin position="372"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5080193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="420" mass="49163" checksum="152D3CD3D86FEDA1" modified="2023-09-13" version="1">METILEISQTLEKQSNDHILTFQQNYQKQIDWLQLFVQKISSSISRRKEAFLTKTNLIQQIQQNLVIQKNSNDSQKNHKSTKKKKNNNNNKKNKLNKNSQKTRKLKSPTFFSSELPKIQEENNEENNIVIGENQNKNQENILKEEVEKDQQKELKKKNIQEPSTLRTEIIVAEELSQSNEKPKINRKLNLQQEIEKQDELSGFDLTKEKLEDEKPQKLGRISEKQKDEEVNYESNDESNYKSFEDLIEESSEETDSEDSYHPSENSEKEEEIQQQQDSKYEVLIDDSDDSEDSYHPSENSEKEEEIQQKQDIQKKQEIKQVPQSCPFLSNSLKFYADSDIDSDSDSESYSNSNADDLEYQMTDHDSSESSNYDSDDLTSNDDSHNGKKIPKWALKPKLHENLILQQTIDPDSIFPLNYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWM0</accession>
    <name>A0A9Q0LWM0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWM0"/>
    <dbReference type="OMA" id="EDCFMEA"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="664" mass="77025" checksum="5EF6093A90B8FC19" modified="2023-09-13" version="1">MVLVQIKNLFQFFQNLVNSQEKQPILIFVAPDCDSICSCKILSFLFQTEMISYSIQPVEGYDEIEEITSKLRDSGIINQTIICINCGGNSDIYKFSNSELDWKFFIFDSHRPIHLENVFSKDQVYVFDDGSIQLAIPTLEPVNTELISPFLSKELEEDLSFENDEDLEDSDFSDIENNENIENIENLSENNENNENNENIENIENLSENEQNSDDFEQEIISVKRRRKKKPKKKDQKTMKISPLIENDEVISELDKYKKNKTNIEKYYSTTTYGLSTSVMLYTLSTQLNRKNPKLLWFAILGLTEHYLLEKIGHRDYLEIVKDFQEEVSYYFPVNNPEKSQSLDSLRFGDEYRLMLFRHWNIYESMLHSSFVASRLGVWKESGFSNLNVMLAKMGLPLDECKQDYQSMNLKLKEQLPQTFRKFAPQFGLKGLIFPSFFKKSAYDVEVTASDIVYLITSLIESAHLNIPQISDINKNFNSNEFSTQNEFSTQNDFKMENFWKAYDSLSNCSSDLFKNGIQLAIRIQKQIVSEGINLIERHSIVSSRSFRHAYLTELSGDRLFFKSATNLSKLGHFLIDIFRQSKKEVKPLILSSLIKEQNIYLVVGVSGTRSFGDISRNKFGQAFLNAATQIKAQIKRDRFESSVMEISIENMKNFMQVLHTLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWM1</accession>
    <name>A0A9Q0LWM1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWM1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="321"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="673"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="801"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="971"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1078" mass="125228" checksum="0A7FEE6F99C26DA1" modified="2023-09-13" version="1">MDEIIFFGLNEKSILFKNKPDSITKPIQFKFENENENENEKQIKQISSGNYSTIFLFKNGKAIEYLNEENDSKQNPSKIQIEENIQKVTVGFRNEAILTIEGNVFAKGKDINSENPNEFINISSLIEDINDRIIQDVVSGAYSIYLLTSNQNVYGIGLNYYGQLDVDSEILKKTKKPILMMKNVSKIFSGNDSFHVFLLNSNQELFGCGNNYYGQLGLGESRKQETKIQKLTKIQNIPKGEIIDIQCGYAHSVMLIENEDENENENPKRKIYSCGKCGVNGLDQNKTTYEFTEIKSSLFENDDNIEFSVGTEHTLILTSNSKLIGFGRNYFGQLGTGDTKDQLIPIQIELPKLRFNENISNYHISCGFNNSFLYYSPLPFSNLEEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLNQNQNEIEKLQEIISKKSIQESNQIFEMIYSNNSNINPKLYSEIKEIINSNEKIEETIKRIYLNENDKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELTIEYLKDSNPNPEKIQIEENIQKVTVGYHNEAILTIEGNVFAKEENINPNNPNEFINISSLIEDTNDRIIKDIVSGYRSIYLLTSNQNVYGIGSNDSGQLGFDSKTLPKTEKPILMMKNVSKIFSGNSSIHVFLLNSNQELFGCGWNFYAQLGLGESRKQETTIQKLTKIQNIPKGKIIDIQCGYRHSIMLIENENENQNQNQNQNQNQNQNPKRKLYSCGSYQLNGLDQNKNIYEFTEIKSSLFENDNIIDFSCGTDHTLILTSNSKLIGFGDNSHGQLGTRDTNTQSIPIQIEFPKLRFNEDISNYHISCGFRNSFLYYSPFLSSFSNIEEDLIKLFERKEFCDISFKTKNGEIIKAHKLILKYRLNQNENEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETIKRIYLNENENEKDFIIERKEKEYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNQIKDEIQITQEIINEIQFGIDYFQLNQTNPNLFDLLINKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWP0</accession>
    <name>A0A9Q0LWP0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger fyve domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000021">
        <property type="protein sequence ID" value="KAJ5079924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWP0"/>
    <dbReference type="OMA" id="QPARICD"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="56456" checksum="6BBC1BDF39425AC8" modified="2023-09-13" version="1">MQINYEENEDYLEDMNEIRELGSKPTVTIAAIVSKDEWLPDDSLQNCLICSSVFTTTKRRHHCRFCGLLICSSCTSKSLDFNLGKTTQPARICDGCRALLSNDSNTEKIPGIMDVAIREGLYSPDEEYDVAKQKRYAGVYFVNLVHDFSKYISVADPNNEIEENETTNQTNFKIQRLSLQTLIKLTYNNERNQEIIRTTPNIFDTLFTVAFSHHQSKHLALELLANISITTISNDLFDPNLRLLSQMKKIPNFILNCKDETAQKPSIRFLYNYLQFCLDERLEFIEEAEFSFLLRIVSVYKTQNPVLTTLALGSISIILSNKKLQHFMISTGGIGLIFQILSDFIHSETRIPLSCLFFATKILWDLVENDENVDSILIYDIRPLLRIVLEVPNAPQIIHHVLNFIMGVSKFPSIEKRFSEDACLVPVIFAIFQPKFPKATKLKALKVVSKLANFVHLKKFLIENQFINFLTVLSSSNDSGIQRLAAEAIQELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXZ9</accession>
    <name>A0A9Q0LXZ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000031">
        <property type="protein sequence ID" value="KAJ5079493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXZ9"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="341"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="380"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="423"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="525" mass="61316" checksum="6121EDC332F739CD" modified="2023-09-13" version="1">MKKEYLQEFNKRIINLKDLFEQNRKKDLENFQKKIEEIQNKFKERKNINLEEIDKKYQELINFPKLKTEEDLKLFEETIQQFKNEFEQNRKEIQEFKEFIQQNKIENENENLEKIIQEIKNRIKFQKNKYLEIIEKKIQEIEIKNENLNEIEKIIQDFNNEIEKRKNEFYSKINPQIKNIQNEIENQKLKIQILQSPEKTTNFLQDLSNSIQQQDQKNGCFILQKFAKENEDNQIEIKKFNGIEPLINVMNNFPNNEDIQIKASEALLIFSGGLKREEIENRKLQGIEISKLNGIKTIINTINNYPNNQIIQEKSISILINIAINSENKIEIRNLKGIEPIIKSMNNFPNNQNIQEKGCGALINIAANDKENKIEIRNLKGIETIIKSMNNFPNNQDIQEKGCGALLNIAANKENKIEIRNLKGIEPIIKAMNNFPNNQDIQKQGCGALWNIAVGNENKIEIRNLKGIEPIIKSMNNFPNNQDIQKNGCGALWNIAAFNKDIQENGCGALLNIAVDNVSKIKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYD0</accession>
    <name>A0A9Q0LYD0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000027">
        <property type="protein sequence ID" value="KAJ5079550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYD0"/>
    <dbReference type="OrthoDB" id="18650at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="112" mass="12753" checksum="B14613746E6DDBA4" modified="2023-09-13" version="1">MIQGSAGSIGSLFRSLGPFLAGSYFSFAEYINFPALVFITLGFIYFIGFLLMLFIKSPELEKSSHFLLKENVTKEEDETNSEKDFLIKIDEKNSETNSERESLIKNDEHQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYJ3</accession>
    <name>A0A9Q0LYJ3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">M0811_04091</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYJ3"/>
    <dbReference type="OMA" id="TLESYMN"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5079778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="95" mass="10885" checksum="49912B9A35BDC92B" modified="2023-09-13" version="1">MTTLRDYVDKKVAVISCDGRFIVGILFGFDQAINIILKDCEERIISEDRSIKKVQLDHIEILRGDDIVLIGEFDTNFEDQFESGMKTDPIKPLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZ52</accession>
    <name>A0A9Q0LZ52_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cortexillin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000014">
        <property type="protein sequence ID" value="KAJ5080078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZ52"/>
    <dbReference type="OMA" id="EMEICRE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="65"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="179"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="429"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="763"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="930"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1131" mass="134687" checksum="A4DC04393065227B" modified="2023-09-13" version="1">MTSNQNQNQNQNQNQNQNQSQNLIRKVSSEEKITTESQNFFSNFFNQRKSRILKHLDRTLSFSEQTQKKTLEKWVQFNLNERNLTFDDLKTDFQDGIKLINLLEVLSGKTIPKYQTKPTTRVLQLENITLCLNLAKSIGISYSICAEDILEQNEILILGMIWNFVQFFSIYSLIPNKEIKPLNLILFWCKKCASSFKIRVDNFSTSFYDGFAFASIIKTYFPDKIDLKNLDSNENEKNVKQVFDILQELGIPQIIDIQEFLERKTDEKSIFIYISILFQKFVKKEEANKLIEQYKVNIREMKKRLQRKNSVDDSQNIQQGISKTNKSPSLSKIKAVKFQNENPDFSLEQMHDKHRKEVQKIEKENEMQILQLFKQLQETQKKIQQTRLQIKKQKERKGIKSNLPSNQDFNINININIENENQNENLPDKTETITKIENLKENLKSIESDINSSQTKFKNESEQFEEKIKLLEKEISEHQKSQEEEQNEKTSLITEKNQLEIELSVMRKEYEKMDARLQKIRTRRLKQEKQLKKVSKISQNETNLKIEEKNENLKKQIEENQLEIDDLIDKNKQKKTNLEKNVVKLKILWEQKSLKNQELKNQLIDDRKNFENERVLLEKHAESYQEKLNVYTEKISKLQNKKKGIKNSIKELEVKKQGIEEEEKQILEEQNLIEKNILGIEEEIRKNEEKLEKLKEDKGSEIDLKNEEIHSSLSKELEELKQKNRDLERKNNMKQRSLKLEISRNEDLKNLIDLNQKLDREQISQLKNEISSLKMMIKNDQENFQKQMEQRLLELRKINGILIDKNEKIQSLEDEVNELQFKIDNDNKRHGKAIVQLEEEIEKEKLQSEKLSKANSALSREFEDSIAKYSTQIEILKERVDDIEENAKKKRKNAKTKLIIEKTFELSRELNFEQQESQIKQVHSDYDTLSRMLNSKIQEIINNKKKIQNEQENEENMRKLIENFVEKNNEYILRIKELEETLKINHEKNNENEEKNRLLSELKEKESKYQDLLKELKKLQFEGEINRQESIRILNQLIKTRLENDSKEKDLNENAQNQNLKELVEKLINSFADSLIHVKKLENEKTEIEKGILSDEEMIKIQKMNTYSKEIEDDQFNLLYELERLNLLSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0M0C6</accession>
    <name>A0A9Q0M0C6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000002">
        <property type="protein sequence ID" value="KAJ5080738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0M0C6"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="195"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="290"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="403" mass="47817" checksum="2311224F95FB0C2D" modified="2023-09-13" version="1">MFLKYFQEILQIIQVGLGESRKEERIQKLTKIQNIPKGKIIDIQCGYSHSIMLIENQNQNQNPKRKIYSCGNWRYNGLGKNQDTYEFTEIKSSLFKNDNILDFSVGYAHTLILTSKSKLIVFGYNEYGQLGTGNTNDYSIPIQIELPKLRFNEDISNYHISCGYSKSFIYYSPFLSPFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNQIEKLQEIISKKSIKELNQIFEIIYSNNSIINPKLYSEIKEIINSNEKSEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIEIGIDYFQLNQTNPNLFDLLINKFNNQKKKNDCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R467</accession>
    <name>A0A9Q0R467_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000143">
        <property type="protein sequence ID" value="KAJ5066414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R467"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="481"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="586" mass="68373" checksum="2605C5927B26341A" modified="2023-09-13" version="1">MNEILFFGKNKYPKFFKNKPYKITKPIQIKFENENENENEKQIKQISTGYFEIIFLFKNGKAIEYLDEEDSKQNPQKIQIEENIQKVTVGYGNEAILTIEGNIFAKGRNINPNNTKEFINISSLIEDTNDRIIQDIVSGANSIYLLTSNHIVYGIGSNEYDQLGFDSKTLPKTEKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGCGWNNSGQLGLGESKKEEEKIDKLTKIQNIPKGKIIDIQCGYTHSIMLIENENPKRKLYLCGNYQFNGLGKNQFTYEFTEIKSSLFENDDYILDFSVGHVHTLILTSNPKLIGFGNNEFGQLGTGDTINQLIPIQIELPKLRFNENIFNYHLSCGYLNSFLYYSALSFSNLEEDLIKLFQRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETIKTIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVKDYSELSNKSFQIFEYWIYSNQIKKEIQITEEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4V2</accession>
    <name>A0A9Q0R4V2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4V2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="119" mass="14478" checksum="20C512C8D581F57F" modified="2023-09-13" version="1">MEKKNAKEKKENQRKKRINQERSRIKNKENAKELKGIKKNLIERKNQRNKKELLKREKRFTFSNTRVDWNKQDNNLSNNLYNILIILFIILIPTLILISLLINISKYSLYPFLDLFYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4X9</accession>
    <name>A0A9Q0R4X9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosylmethionine carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4X9"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="110"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="223"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5067419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="409" mass="47413" checksum="5AE256E88EC22E86" modified="2023-09-13" version="1">MNKTNEEKEIKKEFEPIKHLIAGGVSRIVSVILTAPFDTMKTRVQFHGSHLKSRGYMKGILASLVSTVPSTALSFFLYHYVKTQNQYKNFDEDILPIHHSHFHGLFLHAKNFLINSRPFLDAALARMIVLSIRNPIEISKQRMQLERTALIPHMTLSQTLLYLYRHYGISELFTGYSAYLLRDIISTPVYWFTYDYIRNFPKSGSNKKLNSNLKNQKEKIQKIHPIKHILSVSAATIMSTTLTIPVDVIKTKMQTRRLVENGDKKYSTIMQTAKTVYQENGVKYFIKGLGSRLFSVLPSSIISHFVYEWILEIWDHYKLILSQKMSSFYLSSTLSKGSRISILSSPYYYQENSSFNPLDYFSEHFHSKKKNSNLNQNSNSNPKNILSSLIPFNLTSFKKFPITLNQRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R589</accession>
    <name>A0A9Q0R589_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ovarian carcinoma antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5067003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R589"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nbr1 FW" evidence="1">
        <location>
            <begin position="133"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="224" mass="26245" checksum="23A13BFFDF70B2B3" modified="2023-09-13" version="1">MSQFINIYLQLENESRFYSIPKNITFQLFLDFIYQDTGLKISSINYFDDESDWIFLNSTLELQEAFQSFSDDRLIIKIPNQNENENENENENENQIQNQNQNQNQNQIQNSGTKINEKMSAIIKAKDENNKIELKANENGEFSWIIENNGARKWEGNPIFVFVGGDNFFDSVEFHIKQLNPKESIIVSLKITAPSQKGRFLTFWKLKINDENIGNKTWIDLQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5A1</accession>
    <name>A0A9Q0R5A1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5A1"/>
    <dbReference type="OMA" id="KWETIIA"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1133" mass="135917" checksum="E8B0A50FB19712BB" modified="2023-09-13" version="1">MKLLYIQFKLFAKLPVIFEGGNKKERLFMIKYLSEEIMKQEILIQKIKPTTKPEEIINIITTAEKFVTPSSEINVFFDEINRGSKECIILLKEILLERYIKDTRISNQINLLASIKSFSVNKYNKYDSKDLNKNKYQRKEIDKNIISKLQVIPDSFFEDIYDFGKSIESEESITSLIIYKVLEKLEIFKKLKENSITKSVNLLIKRLFLFYQDYIQNENLNLNENENENENLSIFLKIFKWILNNEIDIKLENQNQNQNENQNQKENQKENDIEYLFERITKSILISLFVVYEYKFKPKSNKQQFFQNLKEYLKKYDVGEIREHFKKIDIQKYLDSMIENLIEKLDIKDKAEKKHIGINQRLKENIFFIFICCFSQIPLYIIGESGSSKVTSLEFILELFNQRDKENKPKFSLSFPHLKEFEIPSNKLIESNKIKDIFKKISKEIDENTINVITLKEINVLKKEVLITFCSEIENNELIKPSVIILSNSEFQLPILYIKLKLERMETYELEQTTESILKSFSKNIADYQIKFLVKILSGIYRNESKIISKQFVQILKGRKPSNQIYGIQDYYSFIKDIGYSISNEQQKKQFSDIYFESLFKHFGIRENILNNILKRENIEEFIDIPKFDLIKLLKEISNNNDNNNLEKISRHLMIFIPDVSIFSILYENFFNNSVLIFETKKENELNFNLEKIEKCVQNGETLVIFNYQKIYNAIYDLLKQNYKTYIYSSINEKTEKINIHPNFKLIIITSKAMKYEFNQPYLLSFFEKYYFDLSYFQNLEKYLNLKQKIETELIKPIKKIQKNEISNEELIIGYNENLIYSLILKYQKEEEKEKKILKLMKNKLIEFFKIEQMIEIYLLNQKQEPQKQKSSLSKTKKEIEIDQAQKKIEENIKYYFTKFERGFSELFQEEIVKKEKKKWIIITQYEEIDIQNIQKQNTDYSFQIEYLEKIKNKEYLIQKIQDEQKNDKFVLFIDVKQNEMKSFYEMKMMIDHKFSESNNNNNENENENENNNNNQNEIEIENENLIISKGKKVDIPNPNSTESIDYFEELKKFGKLKSICEQVFKIALSRIIDLTQEIFKKNNLIKQKILGNQSDNFFNEIETIIKENDYSSEWDLKNYQNKIMEDHSKILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6C2</accession>
    <name>A0A9Q0R6C2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Titin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_12573</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003368">
        <property type="entry name" value="POMP_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01376">
        <property type="entry name" value="POMP_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF73">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040234740" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1485"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="327"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="420"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="520"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="610"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="704"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="805"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="908"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1098"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1194"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1287"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1380"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1528"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1532"/>
            <end position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5068113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1583" mass="174950" checksum="8783D50DBC936443" modified="2023-09-13" version="1">MKQILLSFLIFVFLAIFVFSIPCDFYVDVNGEDNGECTESRPCQKIKFVLDLLQSSGKTICINEGTYQIERTLQHPEFAFNLIGLDGPDVTEINGGNAFRCLFYNLRLDQPEVIIHGITFRHCFSIQGDGGAIKIECEQPLQTNIISNCYFYENNAQKSGGAIYADNCHLSLQNLRIEGNQADNTGGGFACYSATDHPDIEFNNVTIVDNAGGEPLNIDDISLTRGSFISPKAPLSSCTYNTGLPLKDCNLCFNGGNCQPNGECVCQPGSGQPSPQCEFCQLGYYSDLGQDCMECENDKYAPQKGTIQCLDCPGLTKTYGTGQYECTPQQVTNVHLITATSTSLEIGWTNPTLFSIDGYTIYYKLEGGSEQSTQIVGEITQTEITNLESGNYTIRIIAYNPRGDGEETPPYLFQTLNISSPSEVTNLQESTQEKTSTSWKIVWSHPLNDGGSPITTYEIGYCEIGKDDWVYHNVSTSVTSYVANGLLSGEYNVTVRAANNYHFGNISNITIWTLPAISPSIMDPVSLHSKTSVSLELTWIPPTSNGGKSIYGYEIVGYGPQSIQIEVENITTYNITGLLSGEYSIKIRALNGIPGNFSNSVNFSTNDPKPPSKIENIQFISNTQSSINFNWTIPENGGSSLIGYRLSYRISGSNDSWTYVTISPPINIYEIDSLLNGSYDIIIQAKNEKGLGIESDIVTFNTASPTEPSQIITANKIEGETTSISLRWEEPFNGGLLIDNYQIDYKVSTDPEFNESAFTNSTNTSITIEGLQSGKNYSFIIRASNQIGWGNFSIIFTFSTGNSSTPSTVQNLQSISSTSTSITLQWEEPSNTGGEEIIKYTIYYKRLDYPGWLYNNYFVEPSQSIFNYTITGLLSSNYTINVTASNLNGEGDISSINTQTQLPTTPDQPRNISLISSTKGSVYITWQQPLSNGGAQITNYSISWESIDEGTTTGNIMIPSTPLSRNLSVNYSGNYTIYISAINIAGNGTNQTSSVETLSATVPEQINELTHNGSTTTSFSIGWKRPYHGGKEILYFDINCTDGESIFEYTLQTSNQSIIYEVTNLFYATYSCQVSSNNSIGRSLISNTCDFYTLYPSAPSSVRNISLINRTSSSLFLNWIEPLSTGGKPIYTYEITHNHSFNAIETNSTETYFNLTELESGNYSIQIWAKNSRGASPDCDPFNTETLEAQIPFSVDTFRADDVNRYSIKYKWNQPPSSGKPILSYIFTVNQTIDSTIVTNQTLSNTTFEYLVNGLNHSSNYTAQIFAINVLGAGTSITIINETRGFIPEQISEVNSTSYYYQVLFEWIYDDPDLTGYTINITSNDNTTNKTIKVLNPTASSSIITNLIPATDYEIIIRAEIYQNYSEWSLPYSVRTLDYHPEKIQNISMIRKTDTSLTLEWNEPRNNGQPITKYNLDISDETGIIEFIIEAATNSVVIGDLNSTTTYLIQISAVNDIGEGEWSDIMNFTTDSKQETSSSNSKAPVYIGVGVSAGVVVVGLGLFIFFYRRKKAVKVTASVNVYSVNDDDDDLGRDLDDPQNDIPKKGDEDDVSGIVMQTIKAEEDLYLQSVKNESSVFSTTKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7E9</accession>
    <name>A0A9Q0R7E9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7E9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="121" mass="14401" checksum="B8977263F102AC5C" modified="2023-09-13" version="1">MEIENESEKEKEKEKEKEIESESDEESEDEDEDEDEDEDEDEDEDEDEESEGDEIKSNEETDEDEDEDEDESELNNFLVKSDESEEDQEYNDKKSDEDEDDDDDNILETDEDEDEDEDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8N1</accession>
    <name>A0A9Q0R8N1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8N1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="489"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="616" mass="72037" checksum="E7BFAF48275DC34A" modified="2023-09-13" version="1">MNEIIFFGSNKYPKLIQNETEIITKPIQFKFENENENENEKQIKQISSSYFSTIFLFKNGKAIEYLNEKDSKQNPSKIQIENIQKVSVGEQNEAILTKEGNVFAKGNIINPKNPKEFINISSLIEDKNDKVIKDIASGEHSIYLLTSNQNVYGIGLNQYCQLGLDSKTLEKTEKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGCGSNFYDQLGLGNSMESTLKKLTKIQNIPKGKIIDIQCGLFHSVMLIENENENENENENENPKRKLYSCGDWKYNGFDSRGIISKFTEMRSFFFGNNDILDFSVGNSHTLILTTNGKMFGFGNNYSGELGTGNTEFQRGVIQIELPKLRFNEDISNYHLSCGFDRTFIYYSPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLKDENENQIEKLQEIISKKSIKESNQLFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVRDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFKNQKTEQDPEKEEKEEKEEKKNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9S0</accession>
    <name>A0A9Q0R9S0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9S0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000956">
        <property type="entry name" value="CAMK family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="70741" checksum="8D7C29742E29AD99" modified="2023-09-13" version="1">MKKVKKIGNYNLIKVIGSGATGKVKLGEHIETGEKVAVKIIPRVDSIQSITTKQGKKLQSQREITVLKLLNHPSILKICNIYETKQHIFIVMEYMENGELFDYLVKKQFIMNSEALLIFQQLIYALEYCHNHFICHRDLKLENILLDKFGNVKIGDFGMVGFLKNSSLLKTFCGSPQYVAPEIIEGKEYDGTKSDIWSCGVILYILLVGKLPFEGQNTQSILQKIMEEELEFPENFPIHQEELLKGMLMKEPEKRYSIDQIKKNTWFCSNFPLGFVPPSAVLRQRFIRPILNKTISNQVLLELKTFGWDETNIRDQLKKEEPNMEKIFYILFYRKFKKKLKGVIKKDQNSQEKEKEHEKEKDDNDDDEKNSIKKLRLENRKLKRSNSNYQSYSNDFTNELFWIHNEKEKEKEKEKEIEKEKKRSQNSSKNPVQIQLQKKSKTQSKIKIKLKKEPKTTYQWFSNDLNRRRGQNKKRKTPFQNCELQYHKKFIQSKQFQMENLNKSFSKNHKVSVKTKKEIMFIMLQCQIVLNKYGFEWKFPNIFTLKARRRGLKIRFKITKSSISSSDSEKELYFIYKRGEPIEFIQICNQFVDQMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA45</accession>
    <name>A0A9Q0RA45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Ero1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M0811_01626</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA45"/>
    <dbReference type="OMA" id="PCGIRSE"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="29"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="264"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5072611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="344" mass="40189" checksum="7EAE7EEA55CB43E6" modified="2023-09-13" version="1">MIVVNTIYFKYFKVDFLRECPFWVQNYVCSIELGGGCEICVCDDSEIPLPWKEKKTDFVNKNVSSTFHEWYEQKDEDIWIKSDDDKDAMFIDLTLNPEKYTGYGGYNATRIWNSIYSENCFVDAENSDCKEHRVFYRLISGLHGSITVHISQNYYQDGFFFPNVDFYYWKLGKFPERVKNIYFTYLFLTRAIQKSEPFLRNMKIDTGNPENDLKAESLKNKILDTVTGCSPTFEESGMFENQDLKKQMRTKFQNISSLFDCISCQSCKVHAKLQLLGIGTALKLNLAGKGIEPHFERNEIIALFNTFAKFSDSVKIIQEMEAKIQNQNQNQNQNQNQNQKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA58</accession>
    <name>A0A9Q0RA58_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09474</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA58"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="38"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="274"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="579"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="642" mass="74694" checksum="C31E3FBDE7C4C7CA" modified="2023-09-13" version="1">MATAGEWDLLPIQLNQKTKQVLAHFGFTKMTPVQRATIPLLIKNKDTAVGACTGSGKTLAYLIPLFEILNRRQKPFQNNEIGAIVIVPTRELARQVFKITKIFTNFFTQFSVSLITGGKSKKKRNQEKETMEANIIIATPGRLLEYLRNPPQKQKFLLSSLDILILDEADRLLDLGFQLSISNILSYLPKQRRTGLFSATMTDDLDDLIKAGLRNPVYVKVKVENVHNQNDNQNDNQNDNNQDLENENSDNISKNQSIPTSLSNFYYICDYHQKLNQLVHFLLQNINKKFIIFFLTCAQVDFFAAILKSFPFFQSLSKSNDFFLYNLHGRLNQNKRNQTYQSFLDCKNGALLTTDLSSRGVDIPNVDWIIQLDPPQDPNSFIHRVGRTARIGNFGSAILFLSQQEDSYIDFLEMSDVPIKEMKLEDFNPEKKFKEYPNFENLSCKEILDQSPGDIMKIGKQNVLEDRDLFDKGKIAFVSFIRGYKEHKLKYVFQFKNLNIGNLANLFLLIQLPIMKEFKFKSVDDFKPLDININDIKYKNPKKEQARLKKLQEISNSNSKHVPKFEKKYNSFVEKKIKQKINKKKRKKLIENLKKQQEEEAIQKMKEREKEWKELEKETNALKKLKKGKISEKQFEKQFENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAE5</accession>
    <name>A0A9Q0RAE5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAE5"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="447"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="552" mass="64850" checksum="6717FE38C542E77A" modified="2023-09-13" version="1">MNEILFFGSNKYPKLIKNEPDKITKPIQFKFENENENENEKQIKQISSSYFSTIFLFKNGKAIEYLSENDSNQNPEKIQIEENIQKVTVGFDNEAILTIEGNVFAKGKYINPNNLNEFINISSLIEDKNDRIIQNIISGDSSIYLLTSNQNEMIQNHVFLLNSNQELFGCGYNYWGQLGLGESRKEIEIQKLTKIQNIPKGEIIDIKCGIDYSIMLIENENQNPKRKLYSCGYHIDNGLGKNEDTYEFTEIKSSLFENDNDILDFSVGNAHNLILTSNSKLIVFGNNRYYQLGTGDTNNQLIPIQIELPKLRFNENISNYHISCGYNNSFLYYSSPSFSNLEEDLIKLFERKEFCDISFKTRNGEIIEAHKLILKYRLNQNQNENEIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEMIDEIKIGIDYFQLNETNPNLFDLLINKFKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAG3</accession>
    <name>A0A9Q0RAG3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_09215</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5073001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAG3"/>
    <dbReference type="OMA" id="PVRMYCL"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5073001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="276" mass="32083" checksum="35A444D6390244F5" modified="2023-09-13" version="1">MPPRTHKNKLRKKKKIKLKRKKQKIQKQKQKIQQQKLQKIQKIIKGKNMSGNKIENYEKLFTSKDDWYAKSKQFWKESEPTVNGMLGGYEEISEEDTQHSIQFLSQFLDRFSQSKTKYALDCGSGIGRVTKNVFLPSFDAVDLVDSENSFLEVAKQNLDPKKVLNFYCSPLEKFTPDPNKYDLIWVQWVAIYFADDDFVIFLKNCKQALKENGIIIIKDNSSKNNGFVLDESDNSIIRSIPHYKSIFKEANLEILKEETILFTGASLYPVTTFALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAX6</accession>
    <name>A0A9Q0RAX6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAX6"/>
    <dbReference type="OrthoDB" id="10615755at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="311" mass="36591" checksum="33ACA54CFBA0836E" modified="2023-09-13" version="1">MSIQFVPTFGPLKYYLGGLYAPKNEIKYNPDDYLNSLIQRIEKKESKAILETISQLINDSELNFDKINIYEIEFVNYGSLEIIFRLKFTYKSKEMSFIIVSSQLPSLIEKVHQDFIHTKEFHKHFPNLILEVFNYDEFQLSKSKLSISFFTQIDLNLCRCIAKNKSYSENWGIYNPEPIYRFEPFDNELSEFTKQMIIASLIGTYNHKLQKGISCSRASGGDFVLLRNFDYSQKSLKECWRMISVRNEIEIDFQNYCDLIIKEFQISSKISDQKVIDDSLKINHNSKEAFKLETIQKGIELGKEMNKIWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBB1</accession>
    <name>A0A9Q0RBB1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBB1"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="381" mass="43323" checksum="FC2A4D3902A00529" modified="2023-09-13" version="1">MNDCLFFGSNQFPKLIENEPNKIRKPIQFKFENENEKQIKQISTSFSSTIFLFKNGKAIEYSSQNYSNPNPSKIRIEESIQKVTVGGDNVAILTIEGNVFTRGRDINYKNPKEFINISSLIEDKNDRIIQDIIPGAKSIYLLTSNQNAYGIGSNYNGQLGFDSEKLKKTEKPILMMKNVSKISSGNSSSQVFLLNLNQELFVSGYNYYGQFGLGYTIKERKINKLTKIQNIPKGKIIDIQCGTNNSIMLIEDENQNENPKRKLYSCGNYRFNGFGKDENTYEFTEIKSSLFENDDNILDFSVGFSHTLILTSKGKLIGFGNNSYGQLGIGDTKHQLIPTQIEVPKLRFNEDISNYHVLCGNQKSFLYYSPSLSFFPILKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBB3</accession>
    <name>A0A9Q0RBB3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">M0811_08771</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="YGMAVSH"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="18 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="1489"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="1516"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="1546"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="1573"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="24">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="24">
        <location>
            <begin position="210"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="29">
        <location>
            <begin position="1077"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="28">
        <location>
            <begin position="1227"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1443"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="26">
        <location>
            <begin position="1449"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAJ5073363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1609" mass="178262" checksum="C4784765391DD064" modified="2023-09-13" version="1">MNEIIFFGENKYPKLIKNEPEIITKPIQFKFENENQNQNENENENENEKQIKQIATGFFSTIFLFENGKAIEYLNERDSKQNPSKIQIEENIQKVTVGHQNEAILTKEGNVFAKGYNINPKNTKEFTNISSLIEDKNDRIIEDNVSGANSIYLLTSNQNVYGIGSNEYGQLGFDSETLQKTEKPILMMKNVSKIFSGNSSFNVFLLNSNQELFVCGNNEFEQLGLGESITEQEETKIHKLTKIQNIPKGKIIDIQSGSAHSIMLIENENQNENQNENPKRKLYSCGNYFVNGLGNYREDTYEFTEIKSSLFENDDNIIDFSVGNSHTLILTSNSKLIGFGYNEFGQLGTGDTNDQLIPIQIELPELRFNENISNYHIYCGFSRSFLYYSPLSFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLNQIENQIEKLKEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELMSDALQGLTETINILAALLFIFSLYGLRHQETSKKGNFYGMGGMVIAIVALLFSENIKGSGYIVFVIALVPGLIIGLIMAIRVKMTGMPQMVGILNSFGGLAAFLASVSMYLDPGISSTFKGAEMLLLKIFLILGVSIGIITFVGSVFACLKLQGLPGFRGVLQLPGKHFINTILLLGIIGVAVPFVMDDVPNGMWALGIVTALSALYGFHFVMCIGGADMPVVISMLNSMSGWAGVMAGFSVSNDLLITTGSLVGSSGAILSYIMCRAMNRSFLNVFKGGEIAKKPKKGMEQIKEKEPEIYVETNVDEMAQTLLDSKKILITPGYGMAVSQAQHLVSEISKHLRSRGKEVIFGIHPVAGRLPGHMNVLLAEAQVPYDIVLSMDEVNPTIADNDLAIVIGANDTVNPSAVEDPHSAIAGMPVIEVWKAKQVVVIKRTMGHKGYAGIPNPLFYKPNTKMLLGDAKEQISCLLSKIKDIEKQRGVKDSDQIADFDSKCKVDQESKTDTDWVDLDEFETTELETELETYRKIGVVKEIKPNETRVAITPDIAQKLVKKGFEILVETGAGVLANFSDSDYRRFGATILPSASKVWKQADIVLKLEPPMLNNETGVHELDLLPEGGMFASFIYPSQNEDLLERLKHRKVTALSMELVPRITRAQKLDALSSMAKVGGYRAVIESAYHFEKFFLGEVTAAGKYPPAIVMIIGAGVAGLGAIGTAKNLGAIVRAFDTRPVVKEQVESMGGEFLELDFKEDGTGVGGYAKVMSEEFIAAEMRLFAQQAREVDIIITTAQIPGRKAPLLIKKEHVDVMKKGSVIVDMAAQSGGNCEVTRPGEIYKYNGVTVIGLTDLPSKLSTQSSQMYATNLLNLMEEMGNAKNFTFDLENEIIDGMCVSHNGTLRWPKPKPPTPAPAPEPEKKSGPDVPPSPQPPAIKQKKPKSLGRKIFDTTLFWLIAIAIFSLIGIYAPDSFLPHLGILALACVVGWTLVWGVAAALHTPLMSVTNAISGIVILGGMTLVSNQAYTHQSTLLAAFSIFVASINIAGGFLVTQKMLLMFKTEEKVIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBN9</accession>
    <name>A0A9Q0RBN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBN9"/>
    <dbReference type="OrthoDB" id="10615361at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040267638" evidence="2">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="174" mass="19529" checksum="924276273FC49CE2" modified="2023-09-13" version="1">MKFLLILLLFLFVISTHQKETVSELNKENKKINTEKSELFLTITLTLAIVIPVLILNCADNDNSQSTIGGDVFIERSPNAPSKTVTNQINLRYGQADQDLGLTSQYQYGGTVNDILGQNRSQPYQPPVYNQPNMGNQTGDNVGFYMPPPPPNYQQGNNFYQPNQPVAPPSYRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBT1</accession>
    <name>A0A9Q0RBT1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBT1"/>
    <dbReference type="OMA" id="LAYCHNC"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000837">
        <property type="entry name" value="STE family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF2">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5074576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="483" mass="54795" checksum="AB74050095366B86" modified="2023-09-13" version="1">MSVEQNLRGLGIEISTVDPTNLFELMEELGKGSYGSVHKAMHRGTRAIYAIKMICIEAEEDIADIKTEINILKKCSHKNIVRYYGTYFKTDSLWIVMEYCGGGSVSDICQILDHGLNENQIAAVLYGTIEGLKYLHTNHKIHRDIKGGNILLTDKGTVKLADFGVSVQLTKTLSKRNTFIGTPYWMAPEVIQNLEYDSRADIWSLGITAIEMAEIVPPRSDIHPMRVLFKIPMEDPPTLQEPEKWSTEFKNFLSRCLKKNQKERPKSHEISNDPFITGKGKKMYHSNILAELVDEVNRVVSERGYKFPTEEQAVKESESESESESESQTSSSYTDTSESESEDEKKENDKQENKKSRDSWKSVKTNQTFVETKDTSIVEKIKALDRKNCSIPLPFLNLSVIPPEVIVSTSPEHNDIKGALRGLSNDELDFENAQFSSNVGNVIKTFGYYKNKLENVPLNPNETESTNRIYTDLMTTLKTIFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC85</accession>
    <name>A0A9Q0RC85_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC85"/>
    <dbReference type="OrthoDB" id="5987961at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="858"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="928"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="957"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1031" mass="116044" checksum="6339F14626B61F2C" modified="2023-09-13" version="1">MKTEFPGSSGSLTIQNTILRNCKANTSISTILAPVIHATNTNITIDSCEIYGNSIEITNENSSATYSGAIYIENAQEIEIISSLFQSNNNSFNGAGSVYIVEDTTTSNSEMRINGNQFISNIGDIGAIYLQINQVQTAVSLYLENTSFINNNGKTYGAFYIEDNLKNKQLNTEFVDNYFSKNSAEFNGAMGIRHSQSTIFSTSFTNNTFFMNKGSTRTAALSIVFNKLQKVTYQFDSNNFTYNEGFYGAASFQMISTIEQSYSTSVNEDVLVFQQNVFENNNGKLGGSLYFDIRNCNITFSKNQFSNNTAIQGGAIFLTGDGNFFDDGSVYDGNSGEIVSTIFSRITKIFQMNNIVIKTDQNDTIFMEILTDDSSLISTSLKLLQCPIENNWEAKEETHFQFEKQLVFECKRCPIDTYNFATGLESLETEPCFDCPLGGICLGGSDVRANSDYWGVQTDYQGSLKFYFCPFGYCTVKKEEDLHLYNECGNNREGILCGKCKDGYTETLNPSGECVEKTKCSSDSGVYIALALPKALFYAIILLYIPQMKTAHFHIFMHFFQVLMIVLPSIVENPFVALGEILDSFSALFNLQTNLAIFGDAGACPAKSLNAVQKILMQLIGPIVFILAIIFVFLLIKLIQLLRGKNSKNLENENENENENENENKQLDFGDKDKLIEDQEKDKDNNTIPDQKLISDSEIAKWQRAEQQISENVIPPDSQNKNIDNNPDSDTSSLPTLANDEDLSDLADVDIKDINIDKLMKIYPELQKLNLSSEDEGGFGELIERLKEQRDMKGPPYPSYSLGKRLLVGLLTLGIMSHFIILKTLLELTYCIKIKFASGEELRMFRDGEIKCYTTGQIIAIIFTIIVCAFPLVLFFILKKFKKSRRVFTILSPLYFPFKDKYYWYSALMIGWRIALIVVFILINEPVLKAYIVSTFCLLIALIHFQTKPFVSNFHNFLQTVSLMALTFFSSLTVIQAGWSYGGVSLLKQPTKDVNNGLTYFVYALGALSSFYALIIFFYMLFRNIFLEKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCG8</accession>
    <name>A0A9Q0RCG8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCG8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="339" mass="40356" checksum="97FA692777607CC6" modified="2023-09-13" version="1">MEIPSQPHHFHSDTILNPFPNFSFHSNKENFEVSPFENTFHSMKENFDISHLEKQEKQQKNLNQQENNKKKRYQENKQDKNTMLIILDYAVNIQEYRGRWSIPDFYDAKAWSLLNGTLLFGEKRWYIDLKQDLVQSGLEILEGIIKELIEQKEFEPPPRLAIYSDGPRQFKSNSYILFLATRMRKIFQKVEIYTFVAYHGKSACDMHFGSIAKNKKSYGDITSVKDLQNYLGSCLKNTQCKILYPRKGSFKVIQRIPDLRKFHLIRRYNDSLWYEEKLPTQEETQKLKKKNPTKKRRKTDSISPKSISQPISKDPLITRRKYNLRKKQAPERFQKFQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCW5</accession>
    <name>A0A9Q0RCW5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCW5"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="331"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="406"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="499"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="613" mass="71646" checksum="AA6565E921CE588E" modified="2023-09-13" version="1">MNEIIFFGQNQYPKLIKNKPNKITKPIQFKFENENENENENENENENENENENEKQIKQISSGYFSTIFLFENGKAIEYLTEKYSILNVEKIQIEENIQKVTVGGENEAILTIEGNVFAKGKDINPNNPKELINISSLIEDTNDRIIQDVVSGYTSIYLLTSNQNAYGIGDNYYGQLGIDSETLQRTEKPILMMKNVSKIFSGNTSSFVFLLNSNQELFVCGYNNSGQAGLGESIEETQIHKLTKIQNIPKGKIIDIQCRSSYSIMLIENENQNPKRKLYSCGYYQFNGLGKEYQNTYEFTEIKSSLFENDDNILDFSCGDLHTLILTKKGKLIGFGDNEYGQLGTGNTENQLIPIQIKLPKLRFNENIFNYHISCGYLNSFLYYSPSFSNLEEDLINLFRRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNEFENFKEIISKKSIQESNQIFEMIYSNNSKINPKLYSEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVRDYSELSNKSFQIFEYWIYSNQIKDEIEITKEIINEIKKGIDYFQLNQTNPNLFDLLTKKFNNQNQKKNNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDW0</accession>
    <name>A0A9Q0RDW0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDW0"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="142"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="390" mass="44644" checksum="F5484E47C72BEB48" modified="2023-09-13" version="1">MKLFNGKAIKYSKQNPSKIQIENIQKVTVGDQNEAILTIEGNVFAKGKYINPENPKEFINISSLIEDKNDRVIKDIVSGRDSIYLLTSNQNAYGIGSNHWGQLGVDSKTLEKTEKPILIMKNVSKIFSGISSLHVFLLNSNQELFGSGNNVHGQIGLGESIRRKQIKIQKPTKIQNIPKGKIIDIQCGEFHSITLIENENQNPKRKLYSCGFWKDNGFGKDMRKFTEIKSSLFENDDYILDFSCGYNHTLILTSNSKLIGFGDNSFNQLGTGDTKNQSIPIQIELPKLRFNENISNYHISCGYHKSFFYYSPPSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REB2</accession>
    <name>A0A9Q0REB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REB2"/>
    <dbReference type="OrthoDB" id="272549at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="775"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="899" mass="104301" checksum="818D98ED2568A726" modified="2023-09-13" version="1">MSIQEFKSFIPEDNSLVNNFIENLNEKISFSTWVRKQKSKKKFEDRILVITNYRLITIGKRKAHFKYQICRNIHFFSLKEINVLEEKKIQFIFEKFILLCFSDKIPQILQTIFLNFSKFGTQLSKNRTFKFTTKIPEISACFNPEPFVASGFVNLYRSWCNYYQVSPNEEFIKYILNEILNHELESQRTIFNLSNFQGVNDLIQDTKMLSSLIKTLKYNKYFEGFIVDNILKKDTLKSFTSIFKTNSKISKVIISGAQNDIGFAELGKALANNSSININYLDLSLNNFPESAMSSGFYDGISQMKSSLTHLDLSFCQMNSSSISKLFSALSANPRHKIITYLNLSHNNFGESGSSAFANWLKNTHQLYQNENSNESISSKHKFLEYLNLSNCSLKWNIVSQAIADYLSTDHLLFLDLSQNRIQKNSLSSILNMIKKLTTIKFLNLSKLNLIRNSAAQVLSAILSNSNLSGICLNLSGNRLGSTGAESISKIFESSKESNSLEELVIDDCFLKPFGLAILVRSDQKILGNQKRKKIKKIQTNQENQENQENKENKEKEPTKPVEINQNSNENENSNENENDDDYENDDENDDDMETEFENEMDIEIDNSKFSLYSLSSLAFQQNDEYIQPEIDTKDLVFNQSLKRISISRSFLPVTKKKEKHMIEYSFSKLFLQNGLECLRIRGSLNQSFPSQIQIFGSIEKTRLKKLDISQNKLGEILLKQLSQKISNVNCKIQILKVDNNDNTIMSLQEFVYALQNNPNFYYLDWPKEDVKKFLQGKKKKVKRAKEHIQKLRKTIKNYRKNENTYSHYRKRFSRLFNPENLSPKETDDGPEFFFEDCFDITSPDSFHYIQSLEYYKFKKLCQFNIIASFLGNELEFCNNSIFDDDLSDPHFTESSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REB4</accession>
    <name>A0A9Q0REB4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REB4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="405" mass="46830" checksum="FE4EFA3033566D01" modified="2023-09-13" version="1">MVSPHFCMNSFRIAFCCFFLPAFIWLIIDVVTRSKFEKVDCEITDKYYVEYLVEGITDTYVPSYTTPQYRLPNPLDLSPKNVTPFHSFSPHSVSLENLFGANCFPRPTINYISFFQLNYTTKDGTKYSEYACNFGRRCFTRRGTSCKSSSCDKKITSQECKNFANLETDDMYEKYDLGDATCWYSKKYNEYATVHFPLPNFLWSLFFWVPLFFTCIPVFLWLRSEKKGSCDCFKSYDDVCCNCNSRRRGVRNPPIPNNQPMEISGPTQDTHKMSVPEPVGELDGKPDEIKVFDKPPPKLTGNEDFEKMVQIYEDQNQTGNQTGNQTGNQTGNQTGNQTGNNDDIYNEPTGNDEIPMEVIQMQMNEYNSSYNQYYNQQEPQTNDQTNTGPLYNPYNQDSNQGNKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REK8</accession>
    <name>A0A9Q0REK8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport protein trapp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058538">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057651">
        <property type="entry name" value="Ig_TPPC8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24544">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24542">
        <property type="entry name" value="Ig_TPPC8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 second Ig-like" evidence="3">
        <location>
            <begin position="863"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 C-terminal Ig-like" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1401" mass="164367" checksum="9DD63525FC197756" modified="2023-09-13" version="1">MSSYDPPFKIPLSMRRLKNWVWKQYSPLVLVTTSTDAEEICQRNGLSFVEMIRPFATLKDSVSRVQSIQNPSEFQKLPNFHIRFLPLEEISPIDSSEVESRFNSILQQFSNNGKIDSTWPIKNIQSNLFQIPKFKDNPNPWFQPLRRELMNSLRALDFETLNHPVSVISVVSSEIKDPSKVIDSLTEQFDLGKPPQFMKENNMSVDIIRYIVLVHDVAESDINQYFKIEHFIPFSKKNSKVKLGCRLNKNDITALKSKIKISKEDLAKRFRLFKPKGNDIKITKTYTDTSVEMKYRLLADYYFFLRDFQEASNQYKIASNLFKKHQSWNHYLACQEMIILSSIFARLTIDESTIESAILASEKITNNNLKIRLYWNCADVLKMKEEKVSKAADVYISASKIQDNFFAPLSLEQSAFCYYNSNPIQFRKYILYLMLAGKNYGDLNYHSYAIRCLSRCLIGLEGFQWRLAEDHLNHKLARHSFSLKQHQQAITLFKKVFLDSKQQAHMQSVFLTEFQDFFQEFQKLKKYKPIIENFQALSIDLESILISLTDDIFPQLKNTHLFPQEWMRLQEDLLNYITTNLINKKTKQGIKIGNQNQNENQNQNQNEIKIDMQSNQMYNFTGLNSTFRFWNQKNENKAQSFMRRSTVVSEPISIDCVLHNTLKIELQLSRVHIVATYMKEREKKEEKKQQIEMTENEINTELNENIKSESKSESKSESKSKSKSESKSKSNHKSKSKSRSNHKSKSNHKSNHKSKSIGDTKKHHKKDRKQIQFEEREITLEPLEYRKITLKITPLKTGVLKIRGVHATISNSFSTLIEFIPKKYRKNKIHRSFELIVIPEMPLLEAQIENLPKKIFQGSETTAILKLTNKGKIPLHNVYAKIGRPKFFVFGRRNEMGTKIPRFYEQNEEKNKNEEKTIFLEESMISRLVISERNVVKIDTDIIHPGETVSLPLWFRGATTGSVPFPFCFYYESSDPNPMMQFRIHRLLAKSQVLQSLKINTDLQFSFTSISQRILVMKIESYCKNHTLNINQISSLSPEWIIEPLNFKESSVSNKMQNPETNKKHLDLKKKHMFSLDSENQAVVLICKIIPSKKVQMQNSKKEEDQLFKFIVRDLCLHTNAPVDCSQIPHINFLQRERLFSYSRSLLFDSSHNLNQRENKYEMQKSISILNQKKKSSENEDPNKQQNELHRKMRKIMKDHQLDLVLMWEIDGNYGQHNICNIELTTEISTVIYTPRFFSSLVKDKYFNQIIQLQLDAPNSLIHDFSKSPLLLCSVVLHIKNNSQFNFKLDISPEKTKKRRTFHKNSSIIDNFNDSSFFWIEFSKFQIKEFRAYSHIQVPLQICFTKKGVFNIHNFYVHALPFISEEILLSENIKMNLFDLKKFETEIKFHDINEHLIDVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REL8</accession>
    <name>A0A9Q0REL8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rcc1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REL8"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="479"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="582" mass="67612" checksum="E90EBA47A7C7499C" modified="2023-09-13" version="1">MNDCLFFGENQFPKLIKNEPDRITKPIQFKFENENENENENEKQIKQISSRELLIIFLFKNGKAIEHLSENDSKQKIEKIQIENIQKVTVGNGNEAILTKEGNVFAKGEDINPKNPNKFINISSLIKNKKDRIIQDIVSGHSSIYLLTSNQNVYGIGSNIYGQLGSKKPINSKKPILMMKNVSKIFSGNTSKHVFLLNSNQELFSCGYNLFGQLGLGESRKEETEIQLTKIQNIPKGKIIDIQSGNFHSIMLIEDENQNPKRKLYSCGFAKYNGLEKDGTKREFTEIKSSLFENYDNILDFSVGNAHTLILTSKGKLIGFGNNVYGQLGTGDTNFQSIPIQIELPKLRFNENISNYHISCGYYKSFLYYSPLSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETIKRIYLNENGKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIKITQEIIDEIKIGIDYFQLNQTNPNLFDLLIRKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFB5</accession>
    <name>A0A9Q0RFB5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000050">
        <property type="protein sequence ID" value="KAJ5078686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFB5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="236" mass="27062" checksum="366F9438C0C60015" modified="2023-09-13" version="1">MNDCLFFGSNQKPKLIKNKPNEIKKPIQFKFENENENENEKQIKQISSSFFSIIFLFKNGKAIEYLRDSKQNPEKIQIENIQKVTVGALNETILTIEGNVFAKGMNINPKNPYQFINISSLIEDTNDRIIEDIVSGYNSIYLLTSNHNVYGIGDNEHGQFGFDSVTLRKTEKPILMMKNVSKIFSGNSSKYVFLLNPNQELFGCGYNYSSQLGLGESRRNEKKIQKLTKIQNIPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFD0</accession>
    <name>A0A9Q0RFD0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_05266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFD0"/>
    <dbReference type="OMA" id="QIININH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5078009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="907" mass="106507" checksum="AF360F67D9FFF145" modified="2023-09-13" version="1">MKLYKKIKGGFQKETNETYDDQIININHRAIKLERKVAEGGFGFIYEGIDQNTYEKFAVKKLAVFNDEQFEQLQNEVKFQKKLSDHENIVSLFDSQTTHIGNKKNVVILMEYCPDTLVKMMERKLEHSSQFSEDQVLKIFHSICMGVHHMHTQDPPIAHRDLKIENVLIGNDSIFKLCDFGSATTKQYFLESQQERYEAEEDIQANTTLTYRAPEMIDLYRENPITEKVDIWALGCVLYQLLFFKEAFDQGSELQILNGTYEIPKSQANMYSKEIIQLLHLMFTQDPEERPDIFDILDSVCNLMGKKPPQKPKNSIRKKQQNKKQNSQAKNQPNISKQPSHQGDQSQQFFSNFQWYDETNEEVDEPKLDKKGSKKLQKKPNTKMNSKSGKKPVLNLPKNQNRNQNRSQNQNQNQIQNQNQNQSLLDLDFSITPNNYQNLNQHQRISFIDSPNDSNLTRQESELVFDENEYEKQMISQQNQNQDQDQDQIQNQNQNQNQNQNQDQDQNQNALDKTKIELSKEQKFAIFNQVKNDFENKMKQKSLKIQIPKLVIDPKEFVSKRFKKDQLPQFQNKLQKWVATLLKDDPKVWDIKYQTKIISLLWTHKNELKNLMMLLSKFDIGVNPVVGLKSSMLIFQILQDGSFEILRNLCSYYPMFIQLRDGWKKLQTGVFPTLNYHYLNLIIKKIEFHEKFPYFEGSYSLDYFLSQLYDNGIKNSFIFRKSCLLQPPISIETVENLMDLITSFIEFGNLIVSPDFQNIKLLNSCQSNSFLIITNEIQLIYQTICFCLSKLVFVGLSSYKPKDPIFDNFQSLFDKMKNFHLQIKNASEISSLIQVPNFPSKFPDFHLKKTRLNSSSNQSLDEVIYLKTLSYTLRSKFDQEKESKTTPFKKKNYSYSITNKKIEKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFI6</accession>
    <name>A0A9Q0RFI6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_05433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFI6"/>
    <dbReference type="OMA" id="ECRVESM"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="718"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5077743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="844" mass="99625" checksum="CD68B85C8AE72C1C" modified="2023-09-13" version="1">MDNIESKTNLESQTNLETNSQTNLKTNSKTQTNLKTNLKTNSKTNSKTEEDFMNISQTNQNSQTNEDFMNISQTNQNSQTNEDYMNNSQTNDLKTNEDYMNNSQTNQNSQTEEYFMNISQTNQNENNENNQNENNENNENENNENNENNQNENENQKSLPFFVSHFLDCLQIVLEKDSFANTIYFNQNELQIIKNFIQNTSLNEKKIYLRLFARKNLLFRFSEIQQRYSQEIDSSTPLKSILQNLKTQKLFLDNKNKSNISSEQMCQYLKKKDLIEVIQKSAISSPKLSPSKLNASNKKNLKKMILDSIQKQQSNKSFQMTLFGQPILTKNILLSVFGDFVQLDPSKKEIFQRVLFVIFLNDNTSSFSFYSSSSNSNSNSISNSISSDSNSFFPLQETKYPNYKIIKKTPLFQSRQDLLDYIQAREIYLQFHSALYEESELSKQSAFDIFETALSFISDFAHNEQKLNNFISLPQYMQNFSQFWIYIKILTKGIPEFLQKKRNSKKEKQILKLLLSLNFNHPLRNEWFDRITILFNTHLKSKAKAQTWCQKALNDKYLNNLFRFKIERRLTRVQSSPKRKKDEKQEKDDQEEQQLQLSFNLPKEKIIYAKPFRSPKPTSRFAKRLYFSETNPDEILTVEEFALEHYIMEKYYENCVHTETSLWKMLFVVLLWQEIYETQVPDVFQTPYQTYPLDLFTTDFYKNRKTQIDQKLAQISQMNTQELNQYFSLKWESHYGTACIAVSWEKFDFSILLDILACLGGLRLSKILRYFAIDFKLHSSGMPDLCSWSSVKQEFENICLIEVKSQNDRLSDIQKYWITILQKCGVYVEICRVLDFDEKEQKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFU5</accession>
    <name>A0A9Q0RFU5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M7gpppn-mRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFU5"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
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        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA decapping protein 2 Box A" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="76" mass="9565" checksum="A16977A2A58A39E1" modified="2023-09-13" version="1">MQSKLNLFRDLASRFVINSEEFKNEDLIGIIFNIEKAYWFYLDYYYLKFQNDQKFPKFSFHDFYKKYILLKFFKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG16</accession>
    <name>A0A9Q0RG16_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
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                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000046">
        <property type="protein sequence ID" value="KAJ5078747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="16"/>
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        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="37"/>
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        <property type="match status" value="44"/>
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        <property type="entry name" value="USP_3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="596"/>
            <end position="896"/>
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        </source>
    </evidence>
    <sequence length="3018" mass="349717" checksum="47E57819A299E287" modified="2023-09-13" version="1">MSLFFVTFSNKFALFQVEKIINFKNFRKEISFIFSLRNEIKSFYYFFLQKKIEIKNNSSLEIFVGLVKKKHEDLEVYGNIGVLHINYESKIKKNLKKEVNGTVKQFIHKNSFLTLNETNFSVYCSICDKELQGISKWKIQRHCSNRRMKEDATLIQKNQPYFRILEHLQTFSNTDFYSRKEIPTYRTGLSKKRIFKQISDSLPNVDYRKFCFYSSHYFCLKHNTPIFFQCEKCANPNPQKVANHRNKVQMMRNFFKDEVQDPTKLVIILDFGENIQEYRDGWNTQEFYIKNSWVIFNICLIQGTEFEYYDYISEEKSKDSVFVMESLGKFAQILDQKQRKKKLSSYESISIFSDGGSSLKNNLVIPTIIQLFSSNFKKITIGYFLTNHGKNYSDAHFGNISRNRSSFGNIRTIEELDNYLKTLKNTFSTIMSVDRSIKYSYTQGIPYLKKTHLFFYDKGHFEAWFNPQRRGRKRRIPIIKKIQIYDKDLANHNFQIQDVNEKNHSKLIQPISQNLPISRKENEKDVDNQQKEENQKRPFLSQKITKSKKRKNQMIEIDNENQQIEKKNKSNKIPELEIQNLLPLNQNLNRENQVIQTIPNSGNSCYIASIVQILIRTSARNLLPLGDISEKLWDIFNSKQRYIEVQDLRKEVGKHFVNFDNLNQQDLHEFFINLFELLDKETILDIPDKDDLLYHAFDLWNKTILNDFCIRLIQKVKCLECKHFSFSFPQEIGILLSLESEKDCNLIELLNSFFSKNYFDENNLLFCEHCQKKVQSSFQFFLIHIPKFFMIFVKRSFYDPILKEERKNMARIQVPRKIQLNNFLFSPSSSMSNSLSFWGSIHHQGEEQEAKGGHFWAEVKDERNAGDFQVFDDSTTLTIPNPCRKSNSYVLMTYQRDDKRNLLQISIINQSKIEIIKLLIKKGIDINSKTEENETALHFACQYHSFEVIKYLVEKGIDVNIKRIDQKIALHLACQYNSFEVIKFLIENGSDINSQADAKLSPLYFVLKYQKSIEMIKFLVSKGADPTLTTLFNETPLHLVCQYQKPNEIIEYFISKGIDINSKNINHETVLHLVCQYKQPLEIIEYLISKGIDINSKTNGNETALHYACKFQNTLKVIQYLISKGVDINAKTKWNETALHYAFSHKNSNEIIKFLIEKGIDINVKSDFNETVLHIACKNPNSIEMVKILVEKGIDIHATTNQNQIALHIASFFNSLEIVKLLVEKGSDINSTISYREETALHLACQNNPSIEIAKYLISKGIDINAKTIEGKTALHYACQNNSSLEVIQYLVEKGIDINAKTNYNKETALHFACQTNLPLKLIEYLVSKGVDINSQTINNETPLHHACGNINENSLEIIKFLASKGADIAAQTRYNQATPLHFACQHQNQNQNENLFEVIQFLVSKEMELKTHINKTSNQTSDHDHLIYFRKVPSGYLTFNRKTPLHLFCENGNLNSNSIQIIKFLLESGIDINAKTSYGEETALHCLCKNKNQENSNELIKCLIEKGIDINAKTNENQTALHLACQNQNKNSIELIKCLIEKGIDINAKTKRNQTALHFVCQNKNPNSFEVIKLLVSKGIDINAKVYNNQSALHIIYQYQPPKSFDITKFLIESGIDINVKTSHNETALHFTLKYQSNLFEFVEYLISKGIDINAKTNQNETALHYASERNSSIQIVKYLISKGADINSKTNQNETALSISIKKQNENIIKFLLMNNANIDDLKKEYITQEFIDLIPQIYSINEDMNNLLKSNNQFSDLIIQSNDLFKFKVHKLILLTRFDNNELILQKFINNCYQKPKKEIEIILNFIYTGFYNFDKFIEKFNSKQIENENENEKQNENGNENENEKEIIQKFIKEIGIETDWIETKKGRKGIINDLSKLYKENETKDFKIIIEEKEIKIHKLILIIRKLIEIIEYLISNKININEKTNSNKTILHYACEYNSIKIIEYLISKGININLKTNSNETILHFACQNNSIEVIEYLISKGININDKTNKNETVLHYACKKNSIQVIEYLISKGININYKTNQYKTILHYACKNNSLEVIKYLISKGIDINSKTKWNETILHYACKKNSLEVIKYLISKEIDINAKTNRHKTILHYACQNNSLEVIKYLISKGMDINSKTIWNETALHYACQNNSLKVIEYLISKGADINAITGDNATVLHYACESNSVDVIKYLVSKGIDINAITSDNETTLHFACRNNPSFKVIEYLISKGVDINEKNKWNRTLIHLVCENNPSIQVIEYLISKGVDIHEKTKWNEAVLHSACRYNPSIEVIEYLVEKGININAKTNQNETVLHSACQYNPSFEVIEYLVEKGIDINAKTNYDEKPLLSACRNNSSTEIIEYLISKGADINAKTDYNETILHLACRNNSSFEIIQYLISKEIDINAKTNYDETILHYACENDSLQVIEYLISKGADINAKTNQNETVLHYACRSKPLVEVIKYLISKGIDINAKTNQNETVLHLACRNNPSLEVIEYLISKGIDINAKTNGNETALHYACQNNTSLEVIKYLISKGIDINEKTNRNQTALHIACQYNSPFEVIEYLVEKGVNINAKTNQNQTVLHFACRNNSSLEIIEYLISKGIDINAKTRRNQTALHIACEYNSPFEVIQYLISKGIDINAKTNFNETALHFVCENNPSIQIIEYLISKGIDINAKADENETALHYACRNNLSFEIIEYLISKGIDINAKTDENQTALHLISRFNSIQTVQYLVSKGIDINAKNNQNETALHLACQFNFFQIIQYLISKGIDINAKTNQNETALHYTCQNNLSLKVVEYLISKGIDINAKNNQNETALHLACQFNSIQIVEYLIFKGADINSKTNQNETILSISIKKQNENIIKFLLMNDMNIYNLKQKQITKQFIKLFSQIYSINEDMNNLLKSNNQFSDLIIQSNDLFKFKVHKLILLTRFDNNELILQKFINNCYQKPKKEIEIILNFIYTGFYNFDKFIDKFNSKQNENENEKENENEKENENENENENENENEKEIIQNFIKEIGIDSKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG51</accession>
    <name>A0A9Q0RG51_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_05176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG51"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF23">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="315" mass="36162" checksum="D2E4B0EC972829B9" modified="2023-09-13" version="1">MSLNIFLTNDDGYQSPLIIPFIKELEEQKHKVFCCFPEKNWSFSSRIHTVVNVEAKTTELKMGENKTKEIWITNGSPATCGQLGIFHLFKDEKIDLVISGPNSGANYGSFILCSGTIGAAAETACAGLKSISLSFHSYDFGYFRNPQDSTRKKFCNASKISCQVIEKIYKNWPVQEVKYNNIFFNVNVPLDVDPENPSVYYCNPYNDYYGSLLMQVEENSKENSKENSKENSKENSKENSKENSKENQNPNEQKFKKFKLRNDWRVPSENIPYDNDVFALLDDSVSVTVFQPFMKNIKEPIIFKRNEDNSKEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHE0</accession>
    <name>A0A9Q0RHE0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-protein coupled receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_14213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000015">
        <property type="protein sequence ID" value="KAJ5080064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHE0"/>
    <dbReference type="OMA" id="HYNINGR"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022340">
        <property type="entry name" value="GPCR_GCR1_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02000">
        <property type="entry name" value="GCR1PLANT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5080064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="320" mass="37606" checksum="26222DEDF979C8E5" modified="2023-09-13" version="1">MKKPQEICTIIGSSLGFIGSLLIIIFYLLFNQLYFLYRKLIFILSVYDLIQSISYLLPGHSNRIFCRIQFELITGFATCAQFWSASISFISFLKVVKEFDDKKLNKIQKFLHVAMWFISITFILLSFFVGNPEESTTYWCMSTEKPIIIPLYSVNWVYIIACFIFYIFTIIKIRKIIKLNSQGNYGPKTSQMSQVWIQFRLSLIPLIYILIFIPATIRRIRTLINPSANDIFSVDIIHSLFASTQGFWDFWIFVVFDLEMRKKIGNCFSCYSKNRQNAAQLDIEDYKNLRNETFTFSKDLLNSKESERKSLIQNDELEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHQ4</accession>
    <name>A0A9Q0RHQ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor 3b subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHQ4"/>
    <dbReference type="OMA" id="KGEPIGQ"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="290"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="581" mass="68743" checksum="DAF1FFC64924735E" modified="2023-09-13" version="1">MENQFKLSRNQKRNLKRKLRRKKKQLQKKQQQNQNENQNEKENQNQNQNQNEKLETNNAKEEQNQNQNQNLNLEIFYNNPSFKNILEKFNQESLEENQEKNYKDKEDKMKENSDDESDDISDDNDDNNFDKLTDDEKISKKKLKKNFRLTIAELKQLVRKPEVVELHDTNSRDPRLLIYLKSYRNTVPVPPHWSQKRKYLQGKKGFLKPPFKLPHFIEATGISKIRQSLNEKDDSKTLKQKGREKIQPKMGTIEIDYQILHDAFFKYQTKPSLTKHGDLYYERKEQEMKYKSKRPGELSSRLKEALGMPEGAPPPWLIHMQRYGPPPSYPNLKIPGLNAPIPVGAKYGYHPGGWGKCPVDEFGRPLYGGDVFGNMPNQILDQNFDTGIEKIHWGVLEEEFVSESESESESEDIDEKKEDEEIEDQEQLKTEEEKQKQKQRTDLNPEVFEKGITSIPIGFETPDMINLRKGKIKDKENQEEEKKQKSSIQKEEPTLYTVLEEKNTKIGKELVGSSHVYEIPQIQKDDIIINKQFHQQKEIENLKEVEMIIEEKEKEKEKEKLDEKEKKKKKKKKKEKYDFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHW1</accession>
    <name>A0A9Q0RHW1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHW1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="178" mass="20966" checksum="52E40FEE2D1D12DD" modified="2023-09-13" version="1">MAKKLSAFVYFKLLKNNQEIFNEIRNDSIIVFFDGRFDSSRDAQFCTIIFMESGLFPIIWVGNTNLNRANQLFIDGTFKISPKKFTQDLEGKFQIEKQLHQDLKFSMQEGSDLEFGSTFIFLLLQFLPYLKVDRNIIINLDDLSNVKIKNTILNRLKELANNPEKFVQHYEYLTKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI18</accession>
    <name>A0A9Q0RI18_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_04355</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI18"/>
    <dbReference type="OMA" id="QYRVPDN"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000191">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000534">
        <property type="entry name" value="Serine/threonine-protein kinase PKH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="34"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="309"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5079334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="502" mass="57974" checksum="BDDEFFFB9295BD41" modified="2023-09-13" version="1">MSIDPNEEKNSNEDSNSQDKNTINSKKTKTLDDFELGKVLGEGSFGQVLKATEKATGNTFAIKILSKQHILKERKERYVKMERNVLTSLHHPNIIKLFYAFQDQDNLYFVTELAEGGELHDVIRKVGSINEEGSQFIAAEVLSALEYIHSKNIIHRDLKPENILFSADHHIKIIDFGTSKILQPTDGQTVRSGSFCGTAEYVSPEMLKNKEATQASDLWAFGCVIFQLFAGKPPFRASNDYQIFQKILKRDFKFPNGFPKLARDLVEKLLVLDPQKRLGSGGNYAAIKQHPFFEGINFENLQNLEPPTFKPYLPTLEETKNKPEKESQRKSKRRNKSKKENENGNSQDEKSKKPDKDGNSNDEKEENEYDGIDPNRVKLLEEQKKKSKWAKFLLRNELIIESGLVFKKKGLFPRKRHLILTDFPRFLYFDPSKMVKKGEIEWHEKIRAEAKNEKIFYIIIPKRTYHLEDIPCESQRWINAVSKMKDLLTQKSKDATETNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RIB2</accession>
    <name>A0A9Q0RIB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ovarian-specific serine/threonine-protein kinase lok-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_14382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000025">
        <property type="protein sequence ID" value="KAJ5079604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5986703at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="623"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="958"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="515"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5079604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1293" mass="151826" checksum="3521E8CB96BDB87E" modified="2023-09-13" version="1">MSNKNKNLITSFSFNKKITPLHAALSLKAPIQFIQALISRKPDLNIQNVNLKFSMKKKPFYLFDFFLESKSKKNIHRKFKMFLITYSYPKKLMTPLHMALKEKSTDEVVILLLKNGADTSIKDGKISLHYANTCLQIKNILDSNLVDPNIMDGNTPLHDFVIRQSYIEIQYLIDRGASVNLRNKKETPFFLACKYNHFEIAKLLVANGANFKKNAKKDPLNFLENKYKNYLIKKEEMMKYQTKKEQNENKYILYLATFQNEESAFSTQIKKVMGIIENIPQKEIEIKSAKNKLKQIEEINKQILEQIKEKKENFSDLIQKRNGLIIDLQKEVAENANLISKQMEKKTQLKELEKILLEEMKIVFEKTRLISIRTKIAIDHKQKEINKKLAEISKKTPINTREICNAFEVFSCFSTIYGSECKKIVEGYSTLQEESAKKISTGNINDWQETNKQLKESYLKMINFKNKIQIGIYFEVVYNLMWMLRYFIVDFRKSLKKSQNTNKWIKMLSQKARLFTEKKIEMERINSEIVQLEKEKKKIKVEKLNLKIKKEKHFENLEESDSNRLSILKKQHKNTKLEMQKKEKAINKIKHQFYPEMLSEKGYHKTFLWTYLLEKGISMEKNFENVEEIGNENYLNENENENIEKDGDSSLKIRVFKAQKKKGDGSWLIVKAIPLIEIEHLHREVPILVVYDHPNIIHAKMFFQENQYIHLVLPFCNKGNLYQFLLSEKKSPTTSTYISRCFQLIAIFTQILMGLNYLHSEGIYHRNLNLFNILINFENQQIVKLIGFAEDIRFKSTNSGFSEQQKRIHERYIAPEVLQGNPSNTESDMYSFGVVIYDAIFITEKTKNILFQKKPQVSPKEKLEFPDKFTNPTLENLLNRLLNTDPKKRLSAKETLLHSFFTITPNRLQEMISESDKRISTMKTLLSQSTRNRNEQKLYLNRNNMFYESVQAFNQWIDQENLFSPFRSTFDQESAIDAGGLTKDLFSMFFDFAFHPDQKLFRKNDEKSDCYLPVEDPLDRTKAQTYFVIGKAILKSMILQKPINLPMPPIFFAFLLKKENEERSLEDWLSELGHVDGELANQYHTVLLMPDASVIGFEFQNENGEDILVTNNNRREFIVSSCRKILIDNCRSALEKIREGFEISNYIRKNEISDDNSTLKCIQQNLDSFTPSELNLLICGNFQIDSTSVLNEIEFKDWKPQHKTKDFFVRFLKENDKNPNNLRRFLRYVTGLASIPIGGFKKRIFIFYSPQDQINAHTCFNNVDCPEFNDYETFEAMLLSELANLNTGRMKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4U0</accession>
    <name>A0A9Q0L4U0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Negative elongation factor a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4U0"/>
    <dbReference type="OMA" id="METWIND"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="332"/>
            <end position="390"/>
        </location>
    </feature>
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        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="540"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="658" mass="79025" checksum="A66544780B6C7504" modified="2023-09-13" version="1">MSNSFFYSNFNLDKNYSKFRSNKQAPKYQQRQWKHPLKTNSNQQNEQTSKPESLRWKKTNKTKTSEFTKTSENNDKQQEKIEHNQTQTKSRFKKIKSKPDLENETEYEITKIEQKLQKFPPLTDKNNLKENKQQSNNLYEQNQDKIQNKNEIQNEKQDFLIKDKVQDSKTNKPKKHIWKLKKDTKNKNQNFKVSRFTKKKVWNTSQNQNQNQDKNQDKNQDKNQNQNQNQNQNQNQNQDKNQDKNQNQNQNQNQNQNQNQNQNQNQNKNQNKNQNQNQNQNQNQNQNQIQNQDQDQIQNQNQIQNQNQNQNQNQIQIQIQDQDKNQIQNQNQIQNQNQEENKKKSSDKHKRLRSKKNEIKNENENQTQNQNEKTEENKNEQKQNLATENITRNLNSQKNLIENSIEKSNQSNLEFGKLKLGSNDSIRHEDLENHIDLEIQKQQQQQLQLQQKEEEKTKAAGVTFSPHLKIKTNIGLKFGKHQEKNKTENQFQQSRIFSQQKHTTLKKKNILDRAVISFEKGNPKEEERKSIQQEKLNYQLKTKEDQKSQIEIQKEENVKQDINKEEDKKLNSEQLQPKYSQQNQQNQQNQQNQQNQNLNQQNQQNQNLNQNLNQNQNQNQNQQNQNLNQNQNQNQNQNQNQNQNLNQNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L652</accession>
    <name>A0A9Q0L652_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Drab5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000141">
        <property type="protein sequence ID" value="KAJ5066520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L652"/>
    <dbReference type="OMA" id="NDECHHT"/>
    <dbReference type="OrthoDB" id="9988443at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="3">
        <location>
            <begin position="292"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="782" mass="92445" checksum="D776E4C93C8F4898" modified="2023-09-13" version="1">MSFTKSHKLVLLGDSGVGKTSVTFRFANDEFFQYQFPTIGVHNLEKIVQIEDEEIKFIIYDTAGQERFWSITPMYYRDAVAALVVYDITNEDLFEFRDFAEFGKFPKGEIFFIMKQNKGRYFHAGFYYHHNKQTNDTIYFTCSDPKCRGTMRWKNGVPYGGQNHSKECQELSKNRSGPGPFWETVENLAETKTQPSKIFKIAKETSEEWAKNNNNVVQIPNQKLCFYRIREIRKNNSTEDAIQLIQKDPYSRTLNKSTFLRCSINIQCEKEEKIMIWFSDELAKILYQNQQVFVDGTFLSAAKPFQQIVIFMTVDAETNSFVPVVYCALTNKIHTLYTAAFRIIQSLFQQRWKPQCFMCDFEKSLQSSIKAVFQPQILKGCYFHFKQALVKRLEKMKKFQLKDKDTSSALLERIDDLCLVPHDQIPTKIAELQQEFPNYEDFFDYFERTWIKLFPPFLWSNFDDPEFVKRTNCSLERYNRRLNDECHHTKPDLFQMVELLRKEDEHFRTEINNKRKENLTAEKPKNNNKKKSKKQRKRKIEIPFSSNDSLDINQGKVQISHFSSQIKKEENQRMNQTKIENSQLILTNSQETNQKESPHLGILTQEEKQFFHLEIDNQNNDNTNNNNNNNQNENIQKKDLEKTNSEKVKSDPENNQICSFLNFPIKPKIELSPKENGLEKGIVLNSTEKEEEKKIFNQENNLKQNMKGKLEYNKKEDLIQTSFIVGKNDPWEEIVKGEIWSKHMKEIRTEMKKRKIHNTSTLRKGPLIKKFQEYFSQNSQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6M8</accession>
    <name>A0A9Q0L6M8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5067008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6M8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="134" mass="15840" checksum="C9ED4E028CB85716" modified="2023-09-13" version="1">MENNLNQRKTKTNEKTKQNSNQNSNEKLIEKTNENSNQNSNEKSNEKSNENSNQNSNEKTNENSNEKTNEKLIENSLLDKKLEIDKQKLLKYYRERKAGTQIRLGTKLDICVYVSLILAIYIIWVYYYKLPFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L784</accession>
    <name>A0A9Q0L784_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcium binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2157896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1320" mass="148906" checksum="0BD962A3D8BA105D" modified="2023-09-13" version="1">MVTEIISKILQLLQAIREQFSIAESEERERTRVFSLVNKLTEPIQILNESPEEAAQKKEDLEATQNALIDYYQFLSSQVKNENKINPFLRTKETREIFETLESKLNDCITRLSSSIGIEPIEFDISQVIEPQDPNLSSQVMNMGMMMMNLENSNQNWQSPSHTFYISNQENLIPDLARIDSNAESYTFDILREKFGLDKQSAKILFDTFDIERKGSITPQEFKERRKIIEKGSVPDKASFVFKSWDLDKNGFLDIDEVKYALENAYILITKFYFIRKFGNLDKYMKSLNGLEKKRFKKEFKSKVKEMMKKNEVEKYINYMFDQAVKNEDDELSLEEFVKYCEQPNNIVFTFLNALSETMNIFIHEKDIPKEVLDEMKKEKQRMNKKQNKQEKAKLIQEEVQVIEVTTPIKLVKEFSYPNVLLLASDDREEYLNDVENSIKSNGTCFVTTINGKVFIPSFDDLLNFNIIFLYADYNWLDNKQLSENLKLYVESGGKLIICSAFALATDFPNKDLVGSILDYIPLSKGVVSRNEPVKIDLKFGHKILEGVNSFDGGDKSFRIKTNNVNGGQILVKWDDGTPLVTQKTVLGKGGKNGNVIVLNMFPCSTNAIPTGWDRKTNGHRLIANTIYHSFYSPNSIYILPPPRPIPNILIVASDDRDAFLNDVKSSIKINGNCYVKTFNGRISTPKLKKLMKYDVVFLYADYNWLDNLTLSNNLQAFVESGGRLVMCSAFALSNQHPNKDIVGSFLSLVPFSKGIVSRDGPVYLDKTNSPILEGVNYFDGGTASFRIKTNDINGGQVLALWSDGNPLIVQKQIRGYQGKDGLIMVLNMFPCSTDALQVGWNPETDGRKLISNVVQYAFQYQPIILPKEMMFSGLNVLIVASDDRDSYLNDVKASIQANGNCYIKTFNGRISTPSIEDLVIYDVVFLYSDFNWADNKTLSNNLQAFVQSGGRLVMCSAFNLSTQHPQKDLVGSFLSLVPFSKGIISRSGPFYLDKNNNHPILEGVNYFDGGTASFRIQSTNIKKGAEILAKWNDGYPLIVQKQIRGYQGKDGLIVLLNMFPCSNNALQVGWNSQTDGRKLISNVVKYAFEYQPVILPEEIGFSAANVLVVASDDRDSYLNDVKSSIQTNGDCNITTFNGKSSTPTIQDLMGYDVVFLYSDFNWADNTTLSNNLKTFVQSGGKLVMSSAFNLSSQHPKKDLVGDFVSLVPLSKGVVSRDGPVYLDKRNSHEILEGINSFDGGKASFRIKTNEVNGGEILAKWTDGYPLITKKVIKSYQGKNGLIVLLNMFPISSNAISTGWNIQTDGGRLISNIIKYALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7C3</accession>
    <name>A0A9Q0L7C3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7C3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="169" mass="19574" checksum="92FE47C9D0501061" modified="2023-09-13" version="1">MQKYETMLVRVMSVDELTNTNSNINTNSNTNSNINTNSNINTNTNSNTNIDLNIDSNSNSNINSNSNSNSNLTESILTVIKEIEEDIHNFEEGIYQEKLLNYFLEKLSEIVCSLLKEYFQSEIAQEINSFFQVCLRFCSTKIEEENFFALKIISSILHLKKDYKFYENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9L4</accession>
    <name>A0A9Q0L9L4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9L4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="150" mass="17912" checksum="0EB2A2271C1E8589" modified="2023-09-13" version="1">MRNIKKDNNNNNNNNNSNNNNNNNNNDNKNSFILMSLDGNILCRFGSEFKDITTNIIQKKHIPNHHQHFTLINEIRKTLFIFGLLKFHWGIFEIGRNKNKEIRNDIEQELNNFYQLQENFKDNFSQNLSTFKKKIHFNLEQISKNNSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAA8</accession>
    <name>A0A9Q0LAA8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="2">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAA8"/>
    <dbReference type="OMA" id="VAMTWAY"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017702">
        <property type="entry name" value="Carbamoyltransferase_YgeW"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005538">
        <property type="entry name" value="PRK07200.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03316">
        <property type="entry name" value="ygeW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="7">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="6">
        <location>
            <begin position="215"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5067913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="404" mass="45631" checksum="A3435AA9D2E225D6" modified="2023-09-13" version="1">MTEKDKFIEKAKENIEKLKQLKTEIHGTDFLRTWDHTKNDLEAVVYVAQALENMIKANISCQVFKGGLAISNFRDQSTRTRFSYSSAANLVGLANSEIDESKSQVAHGETVRETANMISFFAEFYGIRDDIFLGEGHKFQKEVSDAVADGFKQGVLNSKPPIINLQCDEDHPTQSLSDLIHIAQYFGGLENLKGKKIAMTWAFSPSYGKPLSVPQAIIALMTRFGMDVRLAHPEGYDLIPEIVDLAKKNAEENGGKFTQFNNMEDAFKDADIVYPKSWAPFVVMQERTKLLKQGNAVADQLKQLEKKCIEKNKEFIECDEEKMKLTKDGKALYMHCLPADITGVSCEHGEVSAQVFDKYRIDTYKEAGHKMYVISAMMLLTKFKDVPELLTQLIKENTPRKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAH1</accession>
    <name>A0A9Q0LAH1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAH1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="195" mass="23138" checksum="16053FE5CD2BB205" modified="2023-09-13" version="1">MNFIFKTKRRKYYDIFIDNSKEEVDDDFINLENQIGDLNNNENQEIDVEPITEINIGEEIIYINLENENLLNKKESPKNQLKSIDYSTSLYNDMKGQKLFSKITHLILEIELKLCSSNDIIQYLLQQNALKPFFDLLLQFKTNQNEGKRNFLIQYISIIQKLIQNKNFNLKLIKFIEVEKIIQEILNHLNSTKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBH9</accession>
    <name>A0A9Q0LBH9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBH9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="266"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="706"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="769"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1095" mass="126949" checksum="63A558F4C9DCDECC" modified="2023-09-13" version="1">MNDCLFFGSNQYPKLLKNKPYKIITKPIQFKFENENENENENENENEKQIKKISSSFSTIFLFKNGKAIEYSNPNPEKIQIEENIQKVTVGFGNEAILTIEGNVFAKGYDINSKNPNEFINISSLIEDKNDRIIQDIVSGNSSIYLLTSNQNAYGIGSNQFGQLGFDSETLYKTEKPILMMKNVSKIFSGNASLHVFLLNSNQELFGCGDNEYGQIGLGESRKEIKIQKLAKIQNIPKGKIIDIKCGDSHSIMLIENENQNQNPKRKLYSCGAYLYNGLGKYEDTYEFTEIKSSLFENDDNILEFSCGQSHTLILTYNSKLIGFGWNYYGQLGNGDTKNQLIPIQIKLPKLRFNEDISNYHISCGDYRSFLYYSPSFSNLEEDLIKLFRRKEFCDISFKTKNGSIIKAHKLILKYRLNQDENEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENEKDFIIEREEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELTKPIQFKFENENENENENEKQIKQIASGGFSIIFLFKNGKAIEYSNPNPEKIQIEENIQKVTVGFGNEAILTIEGNVFAKGEDINSKNPNEFINISSLIEDINDRIIQDIVSGDSSIYLLTSNQNVYVIGSNQYGQLDFDSETLEKTEKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGCGTNQFGQLGLGESRKEKKIQNLTKIQNIPKGKIIDIQCGYDHSIMLIENENQNQNPKRKLYSCGNHEYNGLGKNDENTCEFTELKLSLFENDDDILDFSVGNEHTLILTSNSKLIGFGNNNLCQLGNGDTKNQLIPIQIELPKLRFNEDISNYHFSCGYYKSFLYYSPSFSNLEEDLINLFRRKEFCDISFKAENGEIIKAHKLILKYRLNQNQNKIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYFEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNGIQITQQIINEIKIGIDYFQLNETNPNLFDLLIKKSNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBP1</accession>
    <name>A0A9Q0LBP1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase ii subunit rpb3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBP1"/>
    <dbReference type="OMA" id="DETKFHF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="316" mass="35723" checksum="38CF79E91F56B511" modified="2023-09-13" version="1">MNERKFDSTPEIQILEIERDSIKFKLSNVDTSFANALRRIMIAEVPTMAIDLVEFEVNTSILNDEFLAHRLGLIPLTSSSVDEFRYTRDCDCELDDPCGKCSVILNLDVWNKSSGDQSMDRNAKTDAETQLVTSDHLKSADPRVTPVHSMDDDQDDTSHKILIAKLGPDQRLKFKAIAKKGFGQEHAKWSPVCVATYRFVPKIKISYQSPNSEKTQSAYSKIVDSCPARVFKMNQDRIEIENEDRCFFCEECTKKANELDAGINIAIESEPNTFVFSVESTGALKPTEIVLSALRILKEKLRAIHGRLPEDNDLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC02</accession>
    <name>A0A9Q0LC02_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_11291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC02"/>
    <dbReference type="OMA" id="GKEWRIN"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5070087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="452" mass="55887" checksum="E854B8DD290F1C07" modified="2023-09-13" version="1">MGRITIKNQIRSIQRFLSKPNLPENIIEAQKEKLEQLQKRLENKKEAKKSTTLKKNWKKIRFYDKKNILKEIKKVEKELKGIENKNETKIEELEKKLEQLRKDYEYVFYFPKDEEYISLFSENNQKEFHEKMREKIDEMISQKKNKENEKIQESLNEKINEEKIQIQKKKTNEKTNEKTNEKTNEKKSGKKSGKINEEKIQIQKKKINEKNEEKKNEEKDINIFEDEFFKPNSNKNDTNNKQIKQLVIDIDSIEKKEGNKAKKFFHKNKNNFERNKNNFDRNKNNFDRNKNNFDRNRNNFERNKNNFDRNKNNFDRNKNNFDRNKNNFDRNRNNFDRNKNNFDRNKNNFDRNKNNFDRNRNNFERNKNNFDRNKNNFDRNKNNFDRNKNNFDRNKNNFDRNRNNFERNKNNFERNKFKKEIDEDQNNNFKKHKTNIQINTNQKLNKHIRFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCC8</accession>
    <name>A0A9Q0LCC8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ada2a-containing complex component 3 isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCC8"/>
    <dbReference type="OrthoDB" id="301040at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="378"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="663"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="697"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="731"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="765"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1102" mass="126850" checksum="D5376F31DA36E4BD" modified="2023-09-13" version="1">MDLFTIIEQNQIEKLKEIKFIEEKEPQTKQIQVQNSKKEKEKEIILNFAIIKKSSKEMIELLIAKGVKTHLQDQNGRNSLHIAIINNSPIEILDLLIQKGISVNSTDKQNQTCLHFACQNNSSIKVIKYLISKGGDINARTRQNQTILHYACRNQSLEIIKYLVSKKLNIHSKTNYNETLLHYACQHNSIEVIEYLLEKGLDVNAKTFGKETALHYACQHNSIEVIEYLLEKGLDINEKTNFNQSTLHLACQYSSSIEVIKYLIQEGVDINATTNSNQTALHYACQKNSSIEILKYLVEKGIDINAKTATNQNALFYACQSKLSIEIIKFLVEKGIDVNAKTNLNETVLHIACQHKLPFETIKFLVEKGIDINAQTNQQKTALHFACQYNASFEIIKFLVEKGIDINAQTRTEQTALHFASRQNQTVLHYLCQNPNLSFEAIKFLVEKGIDINCKTNQNQTVLHYLCQNPNAPFEVIKFLVEKGIDVNAKTNENETVLHIACQHKLPFETIKFLVEKGIDINAQTSFKQTALHFACQYNASFEIIKFLIEKGIDINAESNLKYTALHLAFQNDSSFEIIKLLLYKGIDINAKAFHEESVLHFACQFNASIEIIKYLVENGVDINAKTASGETALDYLCSKKPSFEIIQYLVEKGIDLHSKSNHNHTSLHLVCLSNPSFEIIRYLIEKGVDVNTKTERNETALHFACQSNPSLDTIKLLVGKAVDINAKAYHNETALHFACHYKLSFEIIKYLIESGIDIHAKTDANQTALHYACQINPSFAVVEYLISKGIDINLKTASNETPLSISIQNGNQKLVQILLNNQANFYDLQEKEISKEFLESFLQVYSINEDFSNFFISDDNFPDYKIESNDFFKFNVHKLILLTRFDNDETILQKFIDICKTKSKEEVQIILNFLYTGFPNFGEIIEKFQHQIEKNSQNDSKSSYFWGGRQFEEQKTILREIEQNQTRIEDFFKQMGFDSNWIESKKGRKGIIKDLHQLYQNESTKDFTIIVEEKEIKAHKLILIIRSELFKGMFLSVQDSSNQVHDYSKKSFETINQLIYFFYHNEFDETKEITKEIIQEFKGLKDYFQLNQHSKIDFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCE2</accession>
    <name>A0A9Q0LCE2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_11512</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCE2"/>
    <dbReference type="OMA" id="FTHRNGR"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="72"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="269"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5069850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="413" mass="47749" checksum="A322188B06AC183A" modified="2023-09-13" version="1">MANYQNQNRYHRNRNYGRSRGRQYNDHKQEEIESNWDICVESFDKMGLKEELSRGIYGYGYEEPSIIQQKGIQPIIEGRDVIGQAQSGTGKTATFAIGVLQKIERNYLTQALILAPTRELASQIGLVVEGLSEYMDVKSYVCIGGTDVEKDKEMLRKGQNIIVGTPGRVIHMIIDEHLKTENIKMLIMDEADELLSRGFKDQIYQIFQELPKDVQVLLFSATMPRDVLEVTKKFMRDPAKILVKKEELTLQGITQFYVDVRQANWKFGTLCDLYKTISVTQCLIFCNKKEDVEDIAKQMLEKDFVVYKMHGEMEPREREQIMRMFRKGKARVLITTDLLSRGIDVQQVSLVINYDLPQKKESYIHRIGRSGRFGRKGVAINFVTEEDFSILKDIQTFYSTQIEEMPGNIADYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCN6</accession>
    <name>A0A9Q0LCN6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transcription initiation factor iih tfiih polypeptide 3-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_11446</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCN6"/>
    <dbReference type="OMA" id="QGCDITS"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5069934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="349" mass="40455" checksum="BF6F6742C911ABBA" modified="2023-09-13" version="1">MSSILGLILDTNIKSWVILEKKYPKIKFKSFLEKLLLFLNSFKILNEKNKYIVIGNNQFKTEFIYPNQNEKEEEEKKSFEEFVDSVQKHLFTTQKLAKKSQEKQPEKSLLSQALSRSLCYLNSEIQKDLEKDKIPKFLKQKNIIKSILTRNKLENEQKNTEEKKTGNISNQQEKTGRNDEIKTDFLAIQPRIFVIQISSDSPSQYIPLMNCVFAAQKSQIPIDVLMLSSQDSQFLQQAAKLTNGIYFRPEIFDESQIFKLMISTYLIDSNSRSNFLFPEPININNSATCFSSGKNIELGFVCSACFSIFSQFYPICPTCKSKISILKPFSKIIEDENENENEIENEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD04</accession>
    <name>A0A9Q0LD04_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_10913</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD04"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000051">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="421"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="648"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5070441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="688" mass="81231" checksum="81FF1A9B95BED82B" modified="2023-09-13" version="1">MNYDEVLAQLVEMFPNKNPMEIKNVIENINNTKNNPNNLFELAIEQLIGNEVENNPQQEEPKNEPDFGFNPFFLTHQNGENVGTNGENFQMNPTNFGINGENFFVNGENKKTKGEKHKTKEDRMHKHLQQHTHRHLHHKHKHEHNYPDFYQPNMEKRKPHNMNLDEKRDELLVSILNMYPEMDPTYLSTLIQTLDEDQLSSPEILMAQLLEDPRAQVNRGGDEVEKMKIYTEDELFASILEILPDAQHKWIKEQINKNFDPQKEMDGLTQVMDVILKQKEYPRQKKEPSKEEIRKKQEEEELKINYYTLKTVLDEEYQRTALNYLLNEFVFVQEKKIKQYFKSNFFRYAPTYKAIREAINDKKIKTQKRPRQKKEFPFTKSDSVIHKELAFIQRQLKAEQAKLDEELAKKLNEEQYEKEGALIECACCFTDVPLDEMVSCNGGHLFCSTCLKRLVEEAISQRKREIYCMSMDGCREKFSREMIEKAVPSKTWNLYQRLLQEQDVDLAGLTNLKKCPFCEYAVIIDDPNTTVLECKNPSCMKASCLKCGELDHRPLKCEEVERDSDTKRRKFIEEQMTSAFLHECNKCHQKYYKVEGCNKIVCSKCSEIMCYVCGKSINREKYGHFGNGKCPLWSTEKEDDERVKKVEEDAKQKMLEDKKKELVELQKHKKENEKNKFDQLLEELKNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDH0</accession>
    <name>A0A9Q0LDH0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDH0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="163" mass="19080" checksum="67F45816270A84EA" modified="2023-09-13" version="1">MENQENNQNIIIDSTIEIQQPQINEAKTLEEKLKILEELFEKSDTKNNEGGTLLHHFATIKPIDMDLFNHFIKEGVDWNQQNWSPVHYLCRNQSITFDVIKLLVDNGANFKLDGWTPLHDLCENTSITKDMVQLLFDKGADFHIQYVNFLNQQKKNIKIHKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE07</accession>
    <name>A0A9Q0LE07_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Non-specific serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE07"/>
    <dbReference type="OMA" id="ECKSFIA"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000537">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="214"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="478"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5069788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="582" mass="67793" checksum="7DFB2CC420260BD2" modified="2023-09-13" version="1">MSNQKRIRRSNKHLHQETTTPDERSLSQKRTENKGKKKTKNRVQYWPAKRKSIFRKIVTPSHVGPTIKFNIIKINSYGKKQRRAITLSKRGLSNISGKSTKWFINSRDIYGIKRSRNRKRFTLVAFHRYHFQCQNEGQANEILTLFKKLNLFHTQQNITDSNSDSSDYESSDEDSDEEINENIPEVEKKKRFSWRRRSKKIQVEEPEKIEQDSFEILKMIGKGSFGKVYLVRKKDNQKLYAMKILVKSELYRRKQIEHTKTEQRVLASLDHPFIVKLHHSFQTKFKLYLILDYVQGGELFFHLKRAGQKRFPQELAVFYVAEIVLAIEYLHQKDIVYRDLKPENILLESNGHIKITDFGLSKEGIVSNDGKTEGEKATTICGTAEYLAPEVITSEGHGKAVDWWSVGILIYEMLVGNPPFYSENRNEMFMKAIQAKPPIPDFLSEEAKDIIRKLLTRSPALRLGANGTHEIKSHPFFKNIDWELLSQKRLDPPFKPKIPENDPSDTSCFDSRFTTFKSEDDQTETNNVDAYLLANLFPHFSFSRKEENNEDQDDNSDFYVNSNSNPNSDSDSDTDSDFHVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LES1</accession>
    <name>A0A9Q0LES1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_10450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LES1"/>
    <dbReference type="OMA" id="MGVMKPD"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5071388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="108" mass="10927" checksum="066013FB1A4032D1" modified="2023-09-13" version="1">MASIIGIYGLIIAVIITTGITEDNYPKYLGFSHLAAGLAVGLSGLGAGMTIGIVGDAGVRGYASQNKIFVAMILILIFAEALALYGLIIGLILGSRSSSAKCNPNPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF92</accession>
    <name>A0A9Q0LF92_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF92"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26087" checksum="088CF1D758EEC333" modified="2023-09-13" version="1">MNEIIFFGENNLGFCFKNEPNKITKPILIPIKFENENENENENEKQIKQISSSIYSTIFLFKNGKAIEYLNKNDSNENPKKIQIENIQKVSSNFDNRAILTKEGNVFAKGRNINPYNPKEFINISSLIEDTNDRVIEDIVSGGSSIYLLTSNQNAYGIGSNEKGQLGLDSGSLKKTEKPILMMKNVSKIFSGNASKHVFLLNSNQELFGCGYNDDGQLGLGESRKEETQIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGE5</accession>
    <name>A0A9Q0LGE5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGE5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="335" mass="39058" checksum="51028E1F3452B487" modified="2023-09-13" version="1">MGVPSSKFISRKMEDFYRKAIQNTAEPILILNQKGSLIEFNRSILNILGFTQPNELLEHSLIDFCPLFQERMGVLSPHAIALLIGSLIENSQKSQNVLFSRFPFQLKDSHNEVVSVEICGSVFIVKKQYYIMFSITPTTHKMTKKPFHPNSLTFSTSSSVITESGDFSSLEELSFEIDKTSIIQPEFFIPNKNTQIQKFNKNIQQQTISSKLKKIITIKTDSKTQKILQTQIQEMEEFFSKNFVRKQTALKYYISKLIQQKNSFRSDVIQFDSILIQKLKEWKKLKLENRKEIFEKLKLKDIVDSTSKFLPLQIDTNFSWIENFENLEFIDSKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGW8</accession>
    <name>A0A9Q0LGW8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGW8"/>
    <dbReference type="OMA" id="SNANHND"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="185" mass="21758" checksum="799C219E630FE2D3" modified="2023-09-13" version="1">MYQPLQKNKSKRKSKRKSNQNQSNQNQIKPKSNQNQSNKSNQNQSNQNQSNQNKSNEINDSSNEKLKKKKSKRKTKNQSNQNKSNKNQLNQNQSNEINDSSNEKLKKKKSKRKTKNQSNQNKSNKNKSNQNKSNEINDSSNEKLKKKKSKRKTKNQLNQNQSNEINDSSNKKQKRRNQKEKQKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGX7</accession>
    <name>A0A9Q0LGX7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGX7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="167" mass="20484" checksum="37AE41D5DF9970E8" modified="2023-09-13" version="1">MIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIETGIDYFQLNQTNPNLFDLLINKFNNQNHDQKKKRKPFLEKERFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGZ5</accession>
    <name>A0A9Q0LGZ5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_10094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGZ5"/>
    <dbReference type="OMA" id="FAGIHFT"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="59"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="547" mass="61222" checksum="C649C7C275E427A7" modified="2023-09-13" version="1">MAQFSRFLIPVPTNQPCWNYVPGTESAIKLKQACEKMRKELPYDVPLIINGKEVRNGKKKEQLICSDHKNVLCKFDVVDENLIQKAVDGAMKAKKHWEELPFETRAGIFLKAADLMVGKYRYEMMASTILGQGKNVWQAEIDCIAELADFLRFNVKFAEEIYSMQPKINPAGMWNRVEYRPLEGFVLAITPFNFTAIGGNLPTSPAILGNVSLWKPSSTSILSNYIFAKILQEAGLPDGVIQFIPGSGSVIGRTLLSNKNLGGVHFTGSTEVFKHIWMEAAKFTMDTYKSYPRIVGETGGKNYHFIHESADLDHVANSTVRGAYEYQGQKCSATSRMYVPKNVWPKLREKLEAIIKQIKMGQSDDFSVFMSAVIDKASFDNIKNYIEGAKKDPDSEVIIGGKCDDSVGWFVEPTVILTKNPKSKTMVEEIFGPVLTIYLYDPDKYEETLDLCDNTSEYGLCGAIFAQERNALDYAVKRLRNTAGNFYINDKSTGSVVGQQPFGGARASGNNQKAGAIINLLNWCSPRSIKENFVPLTDFRYPHMGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIS9</accession>
    <name>A0A9Q0LIS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIS9"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF28">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="874"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="876"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="922" mass="106136" checksum="1BE3FE5024B457F5" modified="2023-09-13" version="1">MGNKPIISKNSPLVFLPQKELENQIECEFCRTGKVTIDKKIFDQIILHKPPIQILRLSFNQLEERSMLAPLLRMKELKALFLQNNKLMELPENFSQELEKLETLNLSSNSFSNITFETDKPLKSLTSLNLSRNHFHIISQSLCKLKSLTYLNLSENHVLEIPNEISYLKNLIELDLSFCLIEKCSSRLGELKNLQKLYLNNNRLITFEPTFSEENNLLELNLAFNKFSETPRCIFQLKHLQWLDLSFNTGMKLEIETENLSSLKTLRLNSLGLEELPKEISSLAETIEEIRIRNNQLVEFPIQLLLPFRRLKTLDLTGNLIDKLEKQIFLRFPSLENFSMGFNKITEIIESLYESGLSLKRLFLNGNPFNQKEQKIIDLGMKKLLRNIEENKPKFADVSQPKKKINPKHELRENSIIIQDHVEKKRDSKVITMNSFQSFRGNKQITIENLNENQNLNENNENNENQNINENNENNENNENNENNENKNENQNENQNENENENQNENENEKEKEKEKENQNENQNQNEKEKEKENQNQNQNQNENQTEKQIEEKIDSNSNKTTQITQISEPVAIPTARRQSKIAIPREKITLEISELKDKIKGTIFGACLGDAIGLASEFLTKKNVAQHYDYELINFNKFIRDRHRKRWIIGDWTDDSDQMILILKSLIDCYGDVDPKDFAKKLLSWAQFGFPELGDSSGTGIGTTVGTVLLNEEFTTNPHKCAFDAWKGKKDNASNGAIMRTSILGIPLFYENKTVIENTVKIAKVTHADPRCHASSVCVTLIIAQILQGKTDLNQIIDLAAQESLNLLSSEDHKKIFKYYISAEKWSDLNLDEKGKIGFTFKALGSAILSLKLFEEPDDFKQILTDLVFEAGDADTNGAVSGALLGCQIGFNKLPQDWIQSLPHSIWLEDLIEKLFLLLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIT1</accession>
    <name>A0A9Q0LIT1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIT1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="141" mass="17136" checksum="236504E5D3E21B18" modified="2023-09-13" version="1">MKLKIFPNKLFVFDPKIKKEENHFILQNFKPLKGNLIHFEFDFRSNIFQFLVKIIEEENIIEQIINNNNISYIGDFILWVSYYFQLALPKNLKEDQNQNENIKPKKVSEINLYNHYLDILFNHIRNFKRLEKSNENDLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIU5</accession>
    <name>A0A9Q0LIU5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucosylceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIU5"/>
    <dbReference type="OMA" id="TEACEGP"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040495102" evidence="4">
        <location>
            <begin position="17"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="5">
        <location>
            <begin position="65"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="403"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="468" mass="53010" checksum="8A80B8ED5FA434E3" modified="2023-09-13" version="1">MKQILILLLFFTFFFSQNFTQIIHVIQTAEFTGDRLTPKADITFQSTPISNITIKLSDANKYQTILGFGGAFTEAAAINFNKLNATLQQQIIEAYYVNLNYRVGRVPINSCDYSASSYSFDDTPDDYSLSQWKLSNGHDLHTVIPMIKAALKATGPNFHLFGSPWSPPWWMKSNGQMNGSNRPGLINDPLIYQSWALYFSKWISAYEAEGIPIWGITIQNEPGFDAPGEACIYSADQEADFLAYYLGPQLKTDYPDVKIMIYDYNKDDVYNYSKTILNRAEAAKYVDGVAFHWYSGPYFENVLKTHEDFPEYFLLASEACVCPGSRGAIWYSGEQYAYDIIGDLNSWAVGWVDWNMLLDMLGGPNHLNASCASPIMIDQNSKTIVYNSEYYYMGQFSKFILPGSVRIDCQIIGSQDIFATSFLTPDGQIVTVVMNLNDVPRFFDLEFNQKFAHVQLPQHSIATFSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ97</accession>
    <name>A0A9Q0LJ97_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Intein-containing myotubularin-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ97"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="430"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="554"/>
            <end position="557"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1237" mass="144984" checksum="480C01FAA76A4506" modified="2023-09-13" version="1">MSKTGFLKNFRIKIGGDQVPNLQEKEDKDKNENENENENENKNGNENMDRKLTFTNRFIDVHTKANQKEKIKKTNEIDNTKKSNENENENKNENKNENENENEIENENEIDNTKKSNKDDKKDDLFGFIDFEDLIRDDFDEEDFDEKIDSLLQIEKNEKFEDLLHQAENKLGIHLESTENEREDDPDILNIENQFSDIDYLSENEEPNDEQENLMEDSIELNNEDEKEKSDSKNDSEVSKHPKKTIIRMDLAKIISPTTKDNSNSRSKFRTIKSMKSIHTAFQFEENETDALENEQIIDIAEKVTWICPLPTGNTLPLVGELHLTNFRLIFVPKELTAHNKVYNRQRNPEFTLGAIQKVEKFGGQSSSRGKLAYGFDVTSNEFQTAKFCFVRKNHSRRHLYLNLIAKSFNSNMTKSFAFEHKTKKVIDSGWEIFDIRKEFQRQGIPNTEWVISGINQKYSLCSTYPNRIVIPAKISERYLKSVAHFRTENRLPLLTWKAPDRPSALIRSSQPKTYSKKSKGAEDEKFITQIFRTNPNGSALRVLDCRSQTEVSNSAKELGFESPDKYREVIHEFLGIEKPQIVRESYNKLRNLCLTSIFQDRKWFSSMEETNWLQMIQKIMEAAKKVVNYMKGDYSVLVHSTYGWDRSVTEDTPVICRLFGSKIIIRKISQLAKENKWEMENEFISREIAEPLESLEVWTEKGFTKVNQIIRHQTNEDIIRVSTQTASVDVTTGHSLLDPNGSKIRSDSVVIGDPLLHVDCPKLEENEISNLSKEISWIFGLFCANGNLNTKEKVLEKKWNILSMNNQVLNKAKSIIEELIFKQEMNQFSGTEIVILCAENEGNTFQLIINPNADTQLKHRFIEYWKNIFCKIHENDEESTDKIEIPDFIFNCENKIKSKFWEGFSSGVKTNFGNWQQKNMSKIQFKSTNTSLICGTYLLAQYFGYKPTIRIENNIKEYENCEYSLRLWKKAKNKNKTEYDQITNLTRYSLPNKKCYVYDISTENHHFHAGIGRMVVHNTAQVCALAELFQDPYYRTITGFEVLIEKEWISFGHPFFSNNGNSFHTSKNKNNSENDFYPIFIQWLDCVYQCLIQFPNYLEFNEAFLLAIAENIYSLRFGTFLFVSEKERNRLKTQENCYSLWTFLNENRENYINPSFMKSNFVLEPSTSMLHIKFWTNYYLQYLFPSIIEEFGTKENFILSKCLDISERINEMEKEEQEIMKEIEEMKKKLKKKDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJF1</accession>
    <name>A0A9Q0LJF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Snf1-related protein kinase regulatory subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJF1"/>
    <dbReference type="OMA" id="HEYKFMV"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043554">
        <property type="entry name" value="KINB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46316">
        <property type="entry name" value="SNF1-RELATED PROTEIN KINASE REGULATORY SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46316:SF5">
        <property type="entry name" value="SNF1-RELATED PROTEIN KINASE REGULATORY SUBUNIT BETA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="183"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="268" mass="31182" checksum="73FA9B6245D7AD3B" modified="2023-09-13" version="1">MGQKNSRGDYETFLEEESQKQTKKKKEKEKEKEKEKQNEKQNEKEKEKQKEKNKKNQEAKNLQEKSKQIPRERRTSKDKNKKPQTTPEVLVPTVFRWKGGGNNVKIKASFTNWEPIKMSQSESDFTLILNLPVGQHKYVYVVDGETAISYHEPITMDENGEMLNITEIKTIDEEMLSPNNSLKKSSPREYSQHVPPILSYQTYPPKIPPLLHHPPITLDTGDDPSHMSIPSHVILNHLYSITREDVVIYSSTNRYKSKFVTTVLYKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJR9</accession>
    <name>A0A9Q0LJR9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJR9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="174" mass="21257" checksum="A538981BD3376775" modified="2023-09-13" version="1">MVNYIHFEFPIHPKKETLNLIWKFLMWGVIEQKRSILNAQLLFWKFEDNFDISFEIPSNRGANSESGLKQFTPLKFIQEFKCELKEEVFGFIEYEINENFEIERKEDRKLKEVARFIEIGKNNFIEFDKPNLKNRQKETYQEPDKNKFWQFLLNTFSEESKEKEKRTINFQTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK20</accession>
    <name>A0A9Q0LK20_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Udp-glucose glycoprotein:glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="QNHENIR"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040284422" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="4">
        <location>
            <begin position="35"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="5">
        <location>
            <begin position="304"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="6">
        <location>
            <begin position="1255"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1532"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1544"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1560"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1592"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1607"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1656"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1666" mass="196647" checksum="B7D689A974B3A473" modified="2023-09-13" version="1">MNNFFFLFLIFSLIFLPNINSNSILTSTIKTKWNKTPLIMEASEFFGLQRNDFFWNFLKEFNNQVQKNETVFYSDKKCYEIVKKIAKNFLTELQIDILDWSIAIHYFNPLVEIHRQLSNNAFEKLSHCDPSLPFIQISKKKFICSLDSIEKDIQKIKENENNLEIFPFDHIFPTNNQIINTKNKITPIILYADITQKTHHLWITKIISIIENLPESQKSIHLVFRHHLVNSKLEEFNVQGYGMFLLPYKNPQYEDFYYNHVPTSVYLQTQNHYSLQDTQIKKIKNEQENFHFQNKQLLSQIRNEMQEESYSNIGLKVAQFIYQSQDPLESLAFISQNFPLISNTIQKIEIDKEFQDKFGKQSDKRNLLKEIVNRENIVVLNGKLLQIEKIDPFYLTQKLTEEIQNYFLLQQFFQDKLLFIGNTSFMLQILDQKPQNHENIRISFGSFEDKIFYLNDQQKSNIIPENNSIEYLVENKMTKYDLYFTNKNLYNIVLMLDPSDSKSLDDVISFYDKMTVGTPFRFGVVFGKNLDSEDDISNPHNYDENDIPIRDLVTGLFAYCREKGGARYPIRFLEEIMNIARSMTDFYESSGIEHNLKKSLFITPRIIKRAFCNIYRGSADLDSLTDCIRKVDHIISKEKYQNIILENEQFLTQKGFTFFPMLSINGRIFPKGLPIPDLINVAKEETFYIEELVKNSQLTSKDDFMQKLSDSQNVFNRWNFDVISTIPTFINFDLNNPFTREFLDTIQYWEPTDPSDIKSITVWIVGDLQSIETVKFLEFFHQSILENQNQKEYNILSELRIAFIHAKDPYQKSQENPTFSSSILCLLGQDINQNCRKSSTPSSLLKIPEKTVQIHKDFYNQYLSDKINMDSPNLIHFVINGRLFSIDLQEPQSSSFENLLLCFQYEFIQRSQNIKDEILAQIEQKSTETKKIDSSRDISDFVSIISSKKGNEKIQRVYKVSQKDIEKVPNLIPIFSTNFSEKNQSFYSELTLILDPLTQHAQKLSHIAHEIQKHIPHLKLNVLLKPQLDADSNARSLDMIYRYLLSGEIVFDEKNNQNDLNNIIVFTDIPQNESFTLFEDVPSNWMVEKISSNADTTAIYIDKWKTKDIQNKNNFLYVDYQLSSILTTGVCMHITSKNFERLPPAEIQLIATKQLLPLSSFQTQEKSHSKDSTFVIISNGYFQLKTEPGIWRITLNDEIKPGFQIYNKETQQNFTDIWITSFIGKTDCNLKIFNTPHAQTKKRSPKDESNDQEHIDIFVPTYGNFQEWSAKILAISVVKHTNSPVKFWFLQNYLSPEFKMELPKLASKYNFTYGTVSYKWPDWIYYKPHKARILSAFKTLFLDVLFPVDVERIIILDPEKLICKDLLSLMKIDFSSYGIAIPKNCYYQDHTKPFIEWKKGYWNKYFQDFPQSKNSFYVVNLDIFRKRPYSDIYRNLYYKLFLLSPNLNPHFDQHLIHYSEQTIPLFILPQNWLWFDFQCGIEKISTNKTFDLCANAFSDEVSLQVFNLIKDEWNLLNEELKNGNEIEIKNQIKNENENENENENEIKNENENEIKNENQNENENENENENENENENEIKNENQNEIENENENQIKKENENEIKNENENEIENENENENENENENENENENQIENENEIENENEIENEIEIEIENENQIKKENEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKK0</accession>
    <name>A0A9Q0LKK0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKK0"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053354">
        <property type="entry name" value="MGDG_epimerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43558">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43558:SF6">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="637" mass="75932" checksum="0ABDD9E6A889F320" modified="2023-09-13" version="1">MKKARKTKTTTKTKRKKIQPIPSLKNICFLQAVKSLETTQNFQTNIEKYKQIPKELLQEIVNHTSFPVFCEFYLRKEFNEIFQKKGSEIFNRKLMEIEQGYRYLFAKKRKDPKLNDPFLLSFDPYKFLERLEYKKWDEYEENVPKLLIPKDFERKISGLSITPKFENFKKNFDIFTENQLDSLDWNNIIVAGGSVLACLQDLPSEVTSTKLNHRKYYLENPCYAKSDIDIFIYGLNKIQAKKKVEQIIALVKNENPHQVYVVRSLRCLTLFSLYPYRNIQIIFRLYKSPAEVLLGFDVDSCAVGYNGKEILMNYRCCRALTKQYNLIDLSRRSPSYEYRLYKYHFRGFAVVIPDYDPKRVDQSIFLKFPNHKQALGLAKLLLLDKFGWEDNPAIYEKAKTRTNQKKNNKNKNKNKKENQMEIEKTKHDDKQYEVLNDPYDKSKRLYMFDKDTWEFREIRILEKSYFHKHFKEMLPEPDFAELANKFAKYETGIPYSDYSAVHVPFGPEIEPEKVIFCLRKKRLLVNSYWRYCRSTTCFPKVTCGIGTDLASTTADMRNFVQSHGWLFWCYEWQDEEDILAFQKLADKFYVNMSRNFAIEWIVTNPGQQLIGSFHPLNADDWFEKAYNEKREEKPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKN6</accession>
    <name>A0A9Q0LKN6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_08027</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle</location>
            <location evidence="8">COPII-coated vesicle membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKN6"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="10">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="11">
        <location>
            <begin position="109"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="12">
        <location>
            <begin position="387"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="656"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5074672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="882" mass="101607" checksum="D9A4E261016D34F2" modified="2023-09-13" version="1">MNEIDNQNKDIFSWKTPNLSPKLFTNIPFSCLFTPLNNKTSIQKLKSNPIYCKQCGSVLNRFSSIDKQTNTWICDFCFSRNEIEKGNMEKTEEITNSTIEYELQKTEKNSPIFIFVIDTAISQSELKSLKNSVLEFIKTLPNNCLVGLITFGKFINIYSLIDSNQEKSYVFQATKTYTEEQIQQFMMTNKTNQDKQSRESNVIQPLHNCRKIISVLVEDIEQDSFYSDDQNRPLRCSGTALLFASTIIPNPEGSGRILLFLGGSCTIGQGSIAEFNKKQPLRFYHDIVNKTENAKLSENAALYYQGIANSLLQKNVAVDIFSCSLDQTGIFEMKECSRKTGGILVSTTKFDSNEFRNSLENLIFPQEDKETDSFDEISLTNQKSLLGFNSSIQIFTSRQLKIKGIIGNCESLNTTSSFVSENVVGIGGTSKWKMCGIDPLATFSIYFDVIAQQLNDPKNVQCLVQILTTYNSIDNKNFIRSTTFSFPSIKDQKINEKEIIEMLNIQTAAILVAKQFVFKREYEQQDEKQFLQLIDNQTFNFLHQVISVPQNKKLKTTPNWIPSKIIEYCELIYELKRSNLVRVFNVSPDESAFLRSIFFRENLTNSLLMIRPQLFSYSLSTPTQTLVDLSFSSIKSNVILIMDSFFLILVFFGKEIAQLQSNLNENQNLNENQNLNQNQNLNENQNQNQNENQNLNQNQNLNENQNLNENQNLNENQNLNENQNLNENQNQNQNENQNENQILNENQNLNQNQNQNQNQIQILNENQNQIQNQIQNQNQIQNQIQNQNQNLNQNQNQNQIQTLINNASKDAQIILKSRFPTPRFIECEQGKSQARYLLSKCKPEKLSNQIKNKSQSILTEEQNFEDYLNFINLELIKSKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLD5</accession>
    <name>A0A9Q0LLD5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLD5"/>
    <dbReference type="OrthoDB" id="2359033at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="299"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="492" mass="57849" checksum="54C82BC561E47B57" modified="2023-09-13" version="1">MENYLNLEKLSNDLKNLFQNQNQNESYFDFEIICEQNQISFKAHKSILSSRSQYFKSLFKSKMKEYQENKMILKDVSSSILFPILNYFYSGKIEINLENAIQILIFSSKYLIDELIQISSNFIKNNLQIETIVDVLKLSEAMNFNQLLNSSYQFISDNFNKFIKTSFFLELEENHLNSILSNDLIPANEFELFQKIMKWGKHKLNINQKKLEKEEKKQLQIQISNIIDKIRFIDFSKQELENILKQDLIPNEISQKLIQFQKLENENDEKELKQFIQKENQNLNSLIFKPRIKLNSSEIIKDKEHIKKIQEWINDDEFFYKMKKGFSGKKDRFNSQKWHNKCDDKGKTLVIIKTKNNCIFGGFTSVGWTTDKSKWSKENRNNSNGWIPDSNAFIFSLRNDKGDRKPEKLPIKKDSKEHAIYYNYSSCGPTFGEGSNGGCDISLNFNLQNGCTNAGNYYKLPKGLKFNSKESRGYLAGSHDKWVVEELETYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLM6</accession>
    <name>A0A9Q0LLM6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sac3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLM6"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="214"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1094" mass="128342" checksum="B24A917BCCB8E810" modified="2023-09-13" version="1">MNTNKKSFFSFISNKTNSTKPKNTLFNTNFQQNKNEEIKTKSVFASIQNKNKNGNENQIQIQNLFQKNKPNNFSLFPKKEDIKQNENQNQNQNQNRNQNESFFKTNKTNLNLFPKKEETQKNENQNGSFFKTSKTNLNLFPKKEEIQKNENQNGSFFKTNKTNLNLLPKKEEIQKNENQNESFFEKIKKKQNQNSLQKIKTNQGNSIVGTCTQMCPQQEIQDRQETHDINYFEVDPETINLDVKYWMIKPEFAVKKYPKTTMEHDPNNIRTLQTLLSTFNYLLNNILERNDVPFYQVHNFLRDRFRSIIQDLNVQNIRNSSTILILETVIRFHILSDYELCTETMENFEASQNNELLDKNLSTLLEIYDENWKKNSNEREEYKNEAEFRCYYLLSSLNSRTPILQKTPTQIITSDDFQFALKVLTDYSTNSFYSFFNNLKKASFLQACLIDRLSNSMRIKGIEIFKKSTPKEKIFPNDDLMDIFGFQTKDDLLFFFQFFNVETSSDFINLKYIQTDASLSRFHSSLIDSKKENYSKLDILLGKSNEYFPIPPKQNINSISISVFPKYQPKILNQETNLIEQKIQFPIQKEKKNLFPKPTSFPIQEEKKTLFPKPTSFLIQEENEIQEENEIQIPIQEEKKTLFPKPIPIQKEKQTLFPKPISIQKENDIQIPFQEEKKTLIQNETLFPKPTSFPIQKENQIQIPFQEEKQTLIQNETLFPKQISIQKENEIKEIQISLFKNQPKNISKIKKRTLEESPLENEHKKPKSIKSKPKSKPKSKSKSKSKSKSNEKPKSKLKSKSKSTKSKSNEKPKSKSTPKSKTKPKSTPKSKSKSKSNEKPKLKSTPKSNEKPKSKSKSKSKSKSKLNEKPKSKSTPKSKSTKSKPKSKSKSKSKSKSNEKPKSKSKSKSKSKSKSKSKSKSKSKSKSKLKLEPNSHLKLKSNKKSNKKLKKEKETESSEYELYFAYPEEEKINENINIISDEEIEINSDQISEEINYNYNYNDLNKENNFNFPQNYSNLIEENQENSFEQNEEMIIQENPNISFLERKMEEEQQEWQENNQKEIEDLESIFRSFNLNPLIVSSSDKLKNLISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMS9</accession>
    <name>A0A9Q0LMS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMS9"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="678" mass="79507" checksum="4E7DFB0D55A64E99" modified="2023-09-13" version="1">MFESNIFNQNEKSKESISLNKKDYDKEIIEEMHNYWKKLTPKFQKLNENQNQIQPDFEIICESGKFCCHKLIVSRSSFLFKKILEGNNKIKLNYPKKLVKKIVQYLYYGKFKIKEYDFIHLFIIADELGLEKFKEKISYEMHKFITKENILDFWIEISSFKEHSLGQKINEILLRNLTLVPENKIGLLSLEKLISLLKLIDQRNNQEEINQNDEIFKDPGGFVLKKMVYIWMQINGPHLISLISRPPKTIINSLSNLQNKDIKYQVDEESNIVVSSQQKYESINEDERNNIKVIIEIMKENLQTENSKSNLDSYNLLNSLSSLSRFCTEGSKLKSYQKTIQEFDGISFVIESLEKFPDNSLLQSNGFDLLANLTIDNFEIQNQIRELKGIEIIINSLKYFPNEIEIQRNGILALSNLIIGNEKNQEIIQKEKGINIIIDSISRSKNIFPIAFSGIFALSNFSFEKPQNQKLIQQREIQIIIEILKKYKEKFSIQSNGFDLLANLTIDNFKIQNQIRKLKGIELIINSLKDFPNEIEIQRNGILALSNLIIGNEKNQEIIQKENIENIIFQVWKEFPDSEDLIENGFLLLKNSKLILKKEIFKESIPKIINLLSKWIENEVIQESGSNLLNRYLKIPEFRKLIKRKVDQILPIIINAKEKFPNSKKIKNFFNKMQNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN16</accession>
    <name>A0A9Q0LN16_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN16"/>
    <dbReference type="OrthoDB" id="239701at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="389"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="57518" checksum="38A77524B72273BD" modified="2023-09-13" version="1">MNEIIFFGLNEYPKLIKNEPDEITKPIQFKFENENENENENENENEKQIKQISSGYNSTIFLFENGKAIEYLKDSKQNPSKIQIEENIQKVTVGNENETILTKEGNVFAKGEDINPKNRKEFINISSLIEDTNDRIIEDIVSGADSIYLLTSNQNVYGIGSNYYGQLGFDSETLETKKPILMMKNVSKIFSGNDSLHVFLLNSNQELFVSGWNYWGQVGLGESIKEEKEITKLTKIQNIPKGKIIDIQCGEYHSIMLIENEDEDENPKRKLYSCGYFRYNGLGKNENTYEFTEIKSSLFENDDYILDFSVGYAHTLILTSNSNLIGFGYNGYGELGTGNTNDQSIPIQIELPKLRFNENISNYHVSCGSYNSFLYYYPSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILRYRLNQNQNQNEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYLEIKEIINSNEKIEETMKRIYLNENEKKMKRFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN96</accession>
    <name>A0A9Q0LN96_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gm2 ganglioside activator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN96"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040127772" evidence="3">
        <location>
            <begin position="20"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="4">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="550" mass="65033" checksum="9B6940CD10F4E4F1" modified="2023-09-13" version="1">MKIITFFVFFLIFLNYSFASFSFNNCGADTDPVVFESYDFPDNFLQINQPITFSFNYSVIPGASIPEGSSATVTIWYQDFAGEPWMKVPVDICSVSNQINCPVSPGEYIFQEINLDVPELPLGQWKVQILLSNSTNRLACNEIYFTTNNGTSPYPSNCEYTSSYKFTATIQQSDVHFQIPDVSSRHKDDWLQIGSLVNYSYSYYSYYSYYSYYSYYYYYSYYYSYYYSYYYSYYSYSYYYSYSYSYYSYYSYYSYYSYYSYYSYSYYSYSYYSYYSYYYYYSYYYSYYSYYSYYSYYSYYSYYSYYYSYSYSYSYSYSYSYSYSYSYSYSYSYYYYYSYSYSLIDSFGNYLNSSQFLWAVNATISQILTDSTYYAYEYSGNFWIGSTELDMNSWTKCFIKGDTVFTVKYLKTNLQLSSLTGEVDVIPITSFPNGWNGPVSFGRLNPATISLDPTSRTLTIEKSEVLCQCEVDPCGVCGGDGSTCQTSKSESKTGVIVASVVVPVVVVSAIIIFLVIYQKRRSKRKLRDDIMNPNIPSYNSSDWTRIGDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNJ9</accession>
    <name>A0A9Q0LNJ9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNJ9"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="218"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="274"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="497"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="603" mass="70508" checksum="40C86445634FCC1E" modified="2023-09-13" version="1">MNEILFFGLNDKPILLKNEANEIKKPIQFKFENENENENEKQIKQISSSFFSTIFLFENGKAIEYLNEDMYGDGDLYEDEDENENNSNQNPEKIQIEENIQKVTVGHEDEAILTIEGNVFAKGKEINSKNPKEFINISSLIEDTNDRIIEDIVSGNSSIYLLTSNQNVYGIGDNQYDQLGFDSETLEKTEKPILMMKNVSKIFSGSSSYHVFLLNSNQELFGYGFNYHGQVGLGESRKKETKIQNIPKGKIIDIKCGLDHSIMLIENQNQNPKRKLYSCGYSEYNGLGKDENTYEFTEIKSSLFENDDDIIDISVGCYHTLILTSNSKLIGFGYNYYGQLGTEDKENQLIPIQIELPKLRFNEDISNYHVSCGYHRSFLYYSPPSFSNLEEDLIKLFKRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNRIINPELYSEIKKIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIINELETGIDYFQLNQTNPNLFDLLINKFNNQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNW9</accession>
    <name>A0A9Q0LNW9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNW9"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="249"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="354" mass="42303" checksum="0505D52EA00DDD14" modified="2023-09-13" version="1">MLIEDEDENPKRKLYSCGYYQLNGLVKNEEKTYEFTEIKSSLFENDDNIIEISVGDYHSLILTSKQKLIAFGNNDFGQLGTGDTNEQLIPIQIEFPKLRFNENIFNYHIYCGDFRSFLYYSPSLSPFSNLEEDLIKLFRRKEFCNISFKTKNEEIISAHKLILKYRLNQNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINLNEKIEETMKRIYLNENENENENENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDELEIGIDYFQLNQTNPNLIDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQY1</accession>
    <name>A0A9Q0LQY1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_05869</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQY1"/>
    <dbReference type="OMA" id="IVWELMI"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000505">
        <property type="entry name" value="Splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5077347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="264" mass="30057" checksum="E252F6C8C441CA22" modified="2023-09-13" version="1">MSAVIKERNQEATLYIGDLDKQVDEELLWELFIQAGPVVSVYIPKDRVTNENQGYGFVEFRSEFDAIYAQLIMNMIKLYGKPMKIARSSQDKKTFDVGSNIFIGGLDPDVDEKMLYDAFSIFGQMISSPNIVRDPETSISKGYGFVSYDSFEASDAAIEAMNGQYLYNKVISVSYAYKKDGRGERHGTLEERYLAAKSANRKMLEMNMFGRSLPNIQPNIQPNIQPNIQPINQRIHNQPINQFPPLNPSFQQPMINPNNPSRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRN3</accession>
    <name>A0A9Q0LRN3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydrogenase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRN3"/>
    <dbReference type="OMA" id="CCIYKER"/>
    <dbReference type="OrthoDB" id="24758at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10549">
        <property type="entry name" value="MtMvhB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027631">
        <property type="entry name" value="Mono_FeFe_hydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050294">
        <property type="entry name" value="RnfB_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04105">
        <property type="entry name" value="FeFe_hydrog_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42859:SF10">
        <property type="entry name" value="DIMETHYLSULFOXIDE REDUCTASE CHAIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42859">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5077269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="517" mass="57339" checksum="90A7E3EA2EAFAA8F" modified="2023-09-13" version="1">MSYVSRKLDWQENFTQKQRVGNEAVRYVRMVLIEIAKLTFQDKLVELVDSLPVKLLPKDRVPIRCCQYKERAVLKQRIMAGLGFGADEIDMDWTPLSVYAQRALNRTKITRPILTIMDIACEHCVQSQYIVTDACAGCFAKPCVNSCPKDAISILPNAKAKIDPGKCIKCGNCMRSCPYHSIIRIPIPCEESCPVQAITRNPKTGFQVLDFNKCISCGACVDSCLFGAIAHKSQVIDVCKFIKDTRRSRQVVAMLAPSIVGQFGKSDLFQIVAAIKMLGFSQVVEVAHGADVTTQHEAKEFLERINADPNTVMTTSCCFSYLELVHKHIPTVKGFVSQTPTPMHYTAELVKNNIPNAICVFIGPCFSKKQESIEDPIVDYAITFEELACLFLAKGIDPIKVKPDTNLLFGNAHKEGRGYPYTGGVSAAVASIIGNKAKVNIHKIDGFSDKTAECLEKFAHHKTPYNLLEVMACKGGCLRGPAVLSRKIVENKKKVQNLQKKSDSLLDNLNPQKETNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS07</accession>
    <name>A0A9Q0LS07_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_05214</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS07"/>
    <dbReference type="OMA" id="IECASTS"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="11"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="206"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="337"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="394"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="546"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="631"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5077957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="807" mass="94136" checksum="8668D089036413F6" modified="2023-09-13" version="1">MKTKIKKLGKQKPTTQDLQATKYFEEYLKRIGLDESQEEREQREIVLAQLSEIFSQFVKEVASKKNLSSQFDGQGSSYIFTYGSYRLGVHDAGADIDTLCVAPHHVTKEDFFKVLPRILSERSEVTEMTPVENAYVPIIKLKFSGISIDLIFAQLSLSVVPRNLDLLNDSILRGVDEKSVRALNGCRVTDQILKFVPNNEAFRTTLRGVSYAILTARICQLYPYSSANFLLPRFFKFYQKWQWPTPISLNEIKESVPGLTHRVWNPKRNQIDQKHLMPIITPAYPAINSTVNVFRSSLTVIKKEFLRACDVCEKFINNCYEKEQVNQFCDELFEKSDFFFRYRNYLMVTASGPDQETHRKWKGFIESRLRTLARSLECEDISYIHLFPKEFDPNIDTKQQNNQNEENNSANNLEKTKSSENNLSNNDLKEEEKKENESKNLQDSNDNKSKKSEEEKEEPKVTFECCWFLGLELKKSHIGNALQQRNINLSKKVTIFINKTFSEVEGEMKGIEPLEIVHLKASELPQFVYDEKDLEKLKQIKREKINKRVKSRQKSHEKETNEIKPEEISSEFSDLNKESENANQETENITQNISDLSNNSDTSPQMIFIENDSNNVNLNNSDQDKNLEMDQNQNGNQNQNLNQNGNQNQNQNQNGNQNQNQDQNENENENLNQNQNQNQNGNQNQNQNQNLNQNQNENQNQNENQNLNGNQNQNQNQNQNQNENQNQNKNQNQNQNENQNQNLNENENQNENENQNQNQNEQQSIQNNHKIDKVRKDLQNDIIHLQTPKIPRISRRKRKKQKLKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT26</accession>
    <name>A0A9Q0LT26_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1222"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="596"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="686"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="965"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1397"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5078196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1625" mass="191460" checksum="B2BCFB4286989364" modified="2023-09-13" version="1">MDVLGIRAIANLIESIPTATRAVVHSDVLQGLISQLSTFKDLDLAELTLSVIEKLTHEHNREVLRNGGLVSVLQFIDFFSVHGQKISAAAAANMCRSIPDSSNDAVISAVPLLIKTLNFHEQKVVDLCCLSIERICDHFINFSDKFIQLQTDEMLQKLILLIQNTTTSLATSISAIKILTNFCIKNPPITLKLYKLDIFTILQKLLNPYNKQETELVQSSSPNLNEVFCSTNKLFHIITFISNLLPPISFEILPEHIQQPLCIESIYANLIEKMSSFQNPLDDNNEHLELLKKNPDFLTQFASSLLNSILFVYDEVIEPYINIQCLLIIFKSFYWLNQLDPTNSIFVYEEEFQSVSEFIISLVSPHLDSHIIGFGIQLSFVLLQNNEVFKYFFLTNGLLDNFHSLLNLYSPLSNDFILISKLYEDLEKEKEKENLEKEKEKENLEKEKENLEKEDLEKEKEKEKEKENNLQNNRKRKYKPKEEKLKRFFFFGSRKKSNKEKKEISKSHNVKINQLPEPQKKTKINYNSQTALWIVKKIQVIIHLFFNEYQNPKSNNLKIYKIDVQISNKHFNEKTQQFSDFKFKTKKIKQNNHEIKSNLKDDQNQDQQFHFDKSRPKMKTSKSAPEFKQTIQQMITRSSSYQFKTSFSHSPYKILSNDEEINDLIERIRSFSKYFFRTQDKNQNLNENQNQNLNENQNQNQNQNQNQNENQNQNENQNQNQNQNQIQNQNQNQNQNQNQNQNQNQIQNQIQNQNQNEEYHLIISEDKDKENENENENKNIETQENNNISPFHILVRKLQQILNKFEQFPVILLSQPKHQLFDRLIRIIFITPRNEKKILKISSDEIYIDPFITVKKMKKVITDKIYGNIKKLRISTIFLKRITLIYYHPSLENQITPIKYLLTLEIQGVALESQRCLLQELYKILFLNHHSKNEKDFLVKSLSEEYHGLIDHIFESSHEIIIRSSEAKNHQEKSPKKSLTKHNSKTKTKNPNKKIKTKNENSNQKPKKHTLKDNLSNIPTKRNENLTNLLEKYGSLQSWIRKLIFLEKDEDFFQVKIPNLNEEEKQDFLQNQKLALKIIKLLYALHEINKSWFFLEQIDENFINYINSYQQAISDSEFISKRLSLKLFRQLGDQFIVYSYYSMPKWIAMLMKKDFLFLFPFNVRLLYFRLKLVGIVRSVLQLQMSLEKHVEDYKNIKLLRLNRFKIRIDRKMLMKSFIKLMKMPKIRGELMVEVEYFDEVGVGSGPTNEFFDIISHELQKKYLGIWIDHGTNKKDIYDSYAETSFGLFPCPLLQEELAITFKSFESKSIEDFTVSRLELFYYIGIFVARAIMDERILDLSFSYPFFKLITGESLTINDLFLIEPEIAKAMIEFSWLVTKYETIKKDRIEQKIREKEEKLKRKKEEESNENDEEKSIKVSLTREEELEIESELEEMEELKYKKVKISDLSLDFTLPGYQEIELIPNGKETDVQLSNLSKYVQLVLEYKLDVGIRKQNLIHLINGYQEKWTKELLLENIKCEHGYTEKDNLVQNLVEILCDLDPTEQKLFLKFVTGNSRLPVGGIACLNPRLTVVKKDVGWCFPDDYLPTVMTCANYLKIPDYSTKDVLKKRIFKAMRDGQSSFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTC1</accession>
    <name>A0A9Q0LTC1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTC1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="716"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="892" mass="104149" checksum="321C027FCA170394" modified="2023-09-13" version="1">MTTEKNEEIKLNTTDQEIKNDSKKPEEDEDKFKIEEVKNKEEKEEENKIEEEKKENKIEKDNIETDKQKEEEETKTNEKKRKEENELENKEEKQNSKEEEKKKAKEETRKFSGILRGKLKSVARHSIQIANTQPVIARSQTFRNQKKGFFDELIEINKAFETENVNEDVLKRFPTAGRLMGYWDSYSRNTFAAKNLMVQSKTTNGKSSTTSTKQSTKKSNFANEKQVKKSPLSIPNNQNHDSKENIIPSLENADNQSENLNDDLFGNISKESVSDSDKNLKNEPKKTKKNQSKSRSNSNPKQKTRSKSRSNSKSQEKQIPQEIQVDSNQEIKPQKIRKQSVLSYAEQLFLDPFALDSDSIFNSDSDAIDKESDEIELPKSPKIKANSKLKSKQKITKKKEKQVENVNQKDDQKTATPDQILKVQTMEITQREFIQTGYELCEIPEFNLEFPLLSNEKPKENIFFKALLDFGDDTQLEFEIDNLMKHSLLKDFSIENVLKIIEDDKIELKKSSHLELVNLKKCYISKDIISICRKAYQIYYLTLDLVEILFEKKESLQENDQTDEKIRNQKIISKIVQFLTKFQVVKHGYISKKTMIENSFINEEERKGKIHKLIHKMTKIRKKRSEEYQEKFNKLFGDVRTTSGLRVDKLAQVVESEEEQIQSSDIYLFINAFTKHLIFKYDIPDEYYKLIYILSSRLIFPKISSFCSKLIESKYGQKDREFAKKTFLLKKMQLKKIGLSSCLLPRKNQNAPKYEIIKNKPENENIESKQTNSKNNSFPFEHAIQKFITIGFRSVPYDSLMFFNKIFNLIIEEAKFYKSSQKKKRNPNQVVLTPKEISSTLSYVLIQANPVNLQTCVAFIQNFSSPEDLESNAGKNFKLFCDSIEFIEQLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTJ6</accession>
    <name>A0A9Q0LTJ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-dependent kinase 11a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTJ6"/>
    <dbReference type="OMA" id="QNTIMFR"/>
    <dbReference type="OrthoDB" id="647at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010556">
        <property type="term" value="P:regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000533">
        <property type="entry name" value="cyclin-dependent kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000172">
        <property type="entry name" value="cyclin-dependent kinase G-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="201"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5078445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="510" mass="60416" checksum="37B690116E11B728" modified="2023-09-13" version="1">MNKRGFDDFNIPENKIYLDNEEINQNQNQNQIQNQFENQNQNQFENQNENQNQNQNQNQNQFGNQFENQNQNQFENQNQNQFENQFENQNQNLNQNQNQNQFENENQFENQFNNQNQNQNENQNQFENENQNQNQFGNQFENQNENQNQNQNQNQNQNENQNQNQNQNKFENENENENENIKKRRTKYQTKFTPCGSVEKYEKINPISEGTYGVVYRARDRKTGEIVALKRIKMDTRQEGFPLTSLREINVLMKHKHQNIVNVREIVVGSSLDRVFMVMEYLDHDLHMLMKTRKNQWTESEVKCLILQLLEGVSHLHKNWIIHRDLKTSNLLLSNNGILKIADFGMAREYGDPLKPYTPVVVTLWYRAIEVLLGSPVYSTAIDMWSVGCIFAELIQGYPLFDAQTEVELIKQIVDLLGPINENNFSGFSKLSISKRIKFNQSQKPKLRAKFNYVSNLCFNLLSELLTYDPEMRISADSAIQHPYFMEHPKPKSSWAMPFYPPTNEHENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUP0</accession>
    <name>A0A9Q0LUP0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUP0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="382" mass="44912" checksum="92ABC936CCF361B4" modified="2023-09-13" version="1">MSLKNKIKENVRHLFITGKAQFNLRISETIFPINLILTHENITIIIGTENKTTEILDYQNTILEVSKKNHIIFRLSILNSLSYIIQTQNYEERLTIYKLFNLFKKYQIRSETIISNNFQIQGKIYNSTSEIRFIAERLYFLEKAHFQLDVIISNKTWISSIIMDQNNFSISSENLPQFSTPWSSNLNCTITEDKFIKVDFDPTKKLYILANSDNLKKLFLQTFHQFFSSRRLFEPNQNIPNSPFFKSPKNIEKHLGSPKKIKKGIQKIRTLGYDQKPEYNRQLTPILIPEEKKLEIFQFEVNLLNPNFSLVHKNIKLLVSSQSIEVVSQTVSTIFKKERTLVSRHSQRNDIFRISIGNHCIYIQFINMNDSDRFAKKVGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUP1</accession>
    <name>A0A9Q0LUP1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar complex 2 and rad4-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUP1"/>
    <dbReference type="OMA" id="WINNDFE"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="518" mass="61445" checksum="A35CBC74A067295C" modified="2023-09-13" version="1">MEISQLKNIIEKNSFITIQNINEILENLQKINKNNFEQFDSEFVLLSIEKIALTFDKILQFDSKKWTKYSNIGIENKKLPNDCEEWNQIMDICLIFVNFVLLLLKENFFEVEKIILKKINQNLLPYFACFETEKAHLGQLLLDFWINNDFEIRKLAFGIYRKISIFSQIDEFQKNLEQIYFQFLKISDYLNSKEESYTNFLQNSILDLYGIDEDISYQLIFIYLRQFAVYLRNATISKELDSICKNICNWQFVNSLKLWGIFFQQKTGMNQKFKPLIYSFIELCIATLKILNSERFIPIRLMIIEILNNLSSETNLFIPTTAFIIEILSFSGNAQNLDQNLDQLKNILYFKSQEEISFFRNQILENALGSLMFFLDLHSYSISFPELVIPIESILKKLVKSIDNISLVGKIDLFLDVLKKNEQFVLNGRKKVIFSEKIISDSGSFLLKERELNKSPISIFLAKEKVNRNEIKEKEKIRKNKKQNQSQQKMKQEMKQEMKQEMKPEMKQEKQQEKQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV12</accession>
    <name>A0A9Q0LV12_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab2a member ras oncogene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000028">
        <property type="protein sequence ID" value="KAJ5079532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV12"/>
    <dbReference type="OMA" id="ISKSYMR"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="206" mass="23270" checksum="99C6A88724F61836" modified="2023-09-13" version="1">MSHSDYDFCFKIVIVGDPHCGKSCILIRYTEDKFTDDYETTLSVGIGTRMIKVDNFQLKLDIWDTAGQDTFKALTKSYFRGAAGAFVVYDITRKDTFETAKVWMNDLRDEVPGIPIILIGNKYDLAHRRQVTSEQAEGFANENKILFQETSAKEGIGIEDAFRGLSKKILIQAQKGENKEVISGKKSSPNIQISSDFEEQKKNKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV71</accession>
    <name>A0A9Q0LV71_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000006">
        <property type="protein sequence ID" value="KAJ5080616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV71"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="311"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="500" mass="59415" checksum="FF9B61365FE8C9C7" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFQNQKQKQSKNQNQNQEESHFDFEIISEQDQISFKTHKSILSSRSEYFKTLFNSKMSEYQEKITLTDIPSPTLFAILNYFYSGKIEINLENAIEILIFASRYLIDELIETSSYFIKNNLQMQTIVDVLNLSEEMSLNQLLEFCYQFISENFYEFIKTSFFLELEENHLNSILSNDKIFTNEFETFQSIIKWGKHKSNINKEKENQKLDNQEREQLQDKISSLVDKIRFIDFSKKEIAKTLKEELIPKQISQKLMNFLILKNEKDQGELSQFIQKETEDPKSLIFKERYKFDSEIIQEKGYVNKLKKWINDNRFFFKMKKGFSAKKDGFDCKKWHDICDNKGKTLVIIKTKDNFIFGGFTQIGFTTDKSKWREDSHYFEDGWITDPNSFIFSLRNDKNDRKSEKFSIKQTQDNFAVYYNYSNKGPTFGKGNDFILNSNLQHGYSNFGYTYNLPKGFDYDTKESRGYLAGSYDSWEVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVP3</accession>
    <name>A0A9Q0LVP3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cerebellar degeneration-related antigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000026">
        <property type="protein sequence ID" value="KAJ5079585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVP3"/>
    <dbReference type="OMA" id="QTKNSRD"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="144" mass="15997" checksum="9F0DD13DA1FD5B62" modified="2023-09-13" version="1">MDQIRLTLEKKPNQNAKLFEKNSNEIQNEIERIKNEINKRISSMSKQTGIKIPFQINQTNLNQDIETKEDNKSNSKSNSNSNSNSKSKSKSKSKSKSKSKSKSKSKSNSKSNSNSNSNSKSKSKSKSNSNSNSNSNSNSNSNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVU9</accession>
    <name>A0A9Q0LVU9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVU9"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="245" mass="29432" checksum="47B187DDAF28353A" modified="2023-09-13" version="1">MKTNQKFKSNSKINLQEFQKRNFQIQELIEDFSQNPPRKDPKIIPTERLLNESNKNLIEIFGKYRDLKKNLILKDGIKKFFLDLLVDPSDIVIYIIFWNFKARKVNELTQMEFVNGWNSFSCQTLEEMKNAIPKFRESVSAIDDFKKFYLYLFSLGSGEPKKVIEIDFAFEIWQKIFSETSEIARNWIKFIDKIKDQIKSITYDTWELTFDFFQEFDSNLNNYDPLSYWPVLIDDFVENFKKNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWN5</accession>
    <name>A0A9Q0LWN5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBP34/UBP24/USP9X/USP9Y-like ARM repeat region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWN5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056850">
        <property type="entry name" value="ARM_UBP34_24_USP9X_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25010">
        <property type="entry name" value="ARM_UBP24_USP9X-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBP34/UBP24/USP9X/USP9Y-like ARM repeat region" evidence="4">
        <location>
            <begin position="542"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1232" mass="144823" checksum="0112EE3AB86D0C24" modified="2023-09-13" version="1">MNENDWEEFRIDLPQKITQEIQEIEKLNNKFQQLIDNKNLDSKQNESILEFTTEVTNSFVDTLTSIGDSFNQKSKIFYEKTIPLFLTFVNLKPFETFEASNSLQFIYQEIILKCIRNFNFDKYKNQKDVKPSLLENALIKKSFKMNFSGQIWTNSTVYSQLEFEDLKTSLYLIENIQFFGSFAGFDLFLNEISSSKSLKLIHIEKMTEIIDRNYFNFDLGFQTHFNEIFVQSVISRLRSFKPEIYQEETQSLFNIFAFFQKKIPILSTDTKINTNSLTAKIEIFINFLLSKSGIEKKNIFFQELDKELESITTKIQDIKEAKLEENCQTFQNIAVALFQYYISTVFDGCCENQLKSNFAKYLKTLLVWLLKYGIFPNELINQIWIFLVNDYLPSKINDTKSMEIMNLFTKIVSFLTTENLSELNNLFQDLEISHPDSRLVSFIDSITRKAIRNKNLNNRNSAKSIEVYLNKISKESKDNIPEKQLISEIEQINIEGFGLLTLWKLLNTVYTGRNLGSQIKKTFQEILFLGECGIYRDYFKLVCLKNLLKRQDIPSSLDLLNEILSFVDPNKSNAKDLNKLSWVEFINAEKKYHLIDLIIEDLSTYYDFSIIEFQKMKGVSEEKFAYHEPFDANAKCLAGNFSHADEIRKRLEFLECLLEKPKITLTFLQINKIWDIIITKHITKTEIDIFFQWLEKLIKENSESGNDEQQSVFEVGKIQSKEINNLATKSTNSIQTDILKKLFTNNICGLDPAHLYPSQFEVFREYFLFHNKENSAIIPLEEDSHRYKVGFEHLLNIISSAIDNSVGQHAIDFCVQLFLSISTQETRKDQFSFLETCMEKFREVSHKYKTESKIQPKETRQSKTKSIMQNSFLVYDPTEITELRIIRFISLFKEFVIQYDEKFSYFKFTEELLPHISRIGFESIKVQIRTENTLCFSFKTYTHIPLLSIVNLVSEIMEIPVNELDSDTCVLSFTRVPNGHPDSISEITQNTQQMKETSVGCFVKMKKLNILSSKTKSYFTANARFPALFLLYEENFDHLVTLWNFSHLIASETFELISLLPTNFRFVEPLFNVSSTIPPPAHIPPNVLKKKADMDEYFKEKSKRKKQNDKQIENPNKTQTEELQNDTIQWDFINKNNFYKLLYQLQTMQLFFFHKEDLCKEKYHFFHFKNYNWCEALFAKGGVDHLITIFTDIVNYFHKKMEELEKKKLSEEQLENKHFSTNFQSGKISELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWX4</accession>
    <name>A0A9Q0LWX4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Serine/threonine-protein kinase fhke-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_03729</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HIWKENI"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="49"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="156"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="430"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="574"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1139"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="441"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1143"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5080245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1448" mass="168940" checksum="7CBEE8E0CA85E405" modified="2023-09-13" version="1">MADIAETLIENDNGLNSSQSQNEMNGIWGKLIPYDRSFEVIDLIGEEPITIGRNLNCSRVFTDRRISTNHCSIFKKPEPNNPNHILIYIKDTSTNGTFINNNKLKKGQQTVLYDSDQISLGSFSGSHIPPVVTYAFRNFLEKKKPIEQSGIHQFYDIRDKILGIGQFATVKEGTEKSTGKQYAIKIIDKNKFILTGQSNNEEKLMTEVDVLKKIQHENIISFKDLFQTETHIYIVLELARGGDLHTQVTHNGKYSEEDAKKILKQLLSVIKYLHEKGIVHRDLKPENILLASKDSTTLIKVTDFGVARVLPESGELSTIAGTRAFLAPEVLLNEVSGGYGKECDLWSCGVILYFLLSGIIPFTETREEKALHQQIIEGDYNFPFDYFKDVSQQGIDLIKRFLVVDPNSRITPEKALEHIWFSNKNLKKSDEIENENENEIENQNQNQNQSEYQSEYQSEYQSEYQSEYQNEYQSEYQSEYQSENEKINQNKIQNKIQNQSEYESEYQSERQNFVSILNDPKQSNLNHWMLGKVIEAPNYMTIFPKISEKYEKSLNLRLKTHFQEMKQLDRIFQQNQKRKKLSEEKRKERNEIPKNIQNNENNNNNNNNNINLDDPSSITIEYIHQIVPQIYFSDKFDLSNNDLFETIYPQSENLQKVLEKQDGFLSLVEKKLLYEVSSKTNSIFTSMVDLSNLKQTVGISLNQISSTRINLHKLDEKSVEDPLTVIKYKTQQSNILKLLKISELLKCAQESIIMINQFILKKDFINALAQIAASNALFNRELKGLDCVKTMKKKIEEEKTKMKDLLIIRFSEICFNESLEDENYQNQTNEKNPDDRLEKIIQSMIIMECVEDSFFNYSQLLGKKIEVTINFELEHLLFPEKSIKMEFGKLISHPERLFSDKQSLLTDNSYIINDERKEKISKIHPKEFRVALKKIYYEIIKVIQNSVEIDKDLEIILQKIPQSLEEKQEKAQIKEKKIMKAKEIWEEYLDQEKQKNIANVQSIPQHLIEQTKKDSKNTIKRACEIAQNKMKKIIHIWKENITQKYNSALLSQTSKEIIQIYKETKNFVKIIQELAKSKFTQLKLEFVDLMKDFLGSLHQNKSAHLEEILNNESWKKQRVSFEFQEIFDKISISSEKSHEYWKNGNNNENNENNENNNNNDEQDQEKKIRTVNYLIVDESKEKRIYVVGSLLMLLKVIEDYIDFARIFPKFARQEIMHQIISILNLFNSKICQLVLGAGAIHVAGLKRITTRNLALASQSLNLIMELSTKLKSIFVHIFSKNDQNLVSGFDKVFEDVQNHKHEIFEKLKSMITKKLQRQIDIFNDYFFPVSNPSKKDKSPKKKPLVVETQQVFFDSLSQDTLKLYNSLNKIIFEHELKEVFKQIQAFFVQEFTKCFSKIDISVFPKSKRDKINQEMVSTINLLNSLQEKCGIKIDFKAVLNLQENFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX48</accession>
    <name>A0A9Q0LX48_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium-independent phospholipase a2-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_14481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000031">
        <property type="protein sequence ID" value="KAJ5079500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX48"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="364"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="738"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="368"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="400"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="566"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="944" mass="109692" checksum="60AF14DF0AF43A7B" modified="2023-09-13" version="1">MKQENNNNNKEEIKNNSFLKLTEKLKEDLQFKSLMQKIFDKQKENQKENQTNENQNQNQNQNFTIKNNERKNKESKTFLEKDLANKNVLQNFKNVSEFTQNHFFNIVKPKIIEKKEENEDDKLEAKITLKDLEDLFGKDCEKQEKEILESKDNERLVDLIVLDILGKDKKEKKKILESQTLDRLIPPIVNSLTGNPQPFMMKNPNLLLLEAKQLLGDKRYQQSYRILDNLFKDEDIDVFTKKIIEETLKNVKEEIENEEKVKQKEEEKNEMKANSWIWKSLIQFDLGNYEESIVNLLNSLLFLDPKDERAGMIQDVLKYIIPEKKEEEKKEEEKEEEKKFKFIEEPEINPKTKQTKDPSKKFILSIDGGGTKGIVPCILLTEIERRTHLRIQDIFDFYAGTSTGGIISLALTRGPISLSLKEILDIYIGEQRYKLFERWSSNSRTILDPIMNGPDFLLYSAYTRKGIDGELDKIFGGCTITDTIKNRGIMVTTSAENYGPCVFANYPISDPYKSGLFRLNEDYSLTLIDDSSFKMAHVAGATSAAAPILPPLTLEKNDGKRITFVDGGFIINNPAAAALVTCRDISNYSLDDTYLLSLNTGTDNLTPVYNWRANLGVIGFLTQSKNFLCKENQVTANLTNRICRDMIGDRYFRFTPFDPEIDAVMLDDVSPENIRRIWNYGVEMIEDLDNQEDNLLNKFCDIVEEYRYANYEFSGTPNPRRFGIGYVTNKVFETTRQQLEEKTKKKEKEKEKEEEKEKEEEREGLGIGRYRMDKESFKKIDEIFTKQEIDEKELSKRLKKFFDARLYSFLKKNDEIKYANFSRWSKHPSVCIASSVGHLSSLQYYSQTNSPLDSIKGPSDWTALHYAAANNEIDSIQFLIFYDILSSNISEEVALNKLKYMECLTDKKKTALQLAKEEKSKQAIELLTELKKFFEKFIKTNQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXF0</accession>
    <name>A0A9Q0LXF0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXF0"/>
    <dbReference type="OMA" id="TEECWER"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="282"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="371" mass="42406" checksum="899A2DF15B47A548" modified="2023-09-13" version="1">MNEILFFGENEKPKLIKNEPDIITKSIQFQFENENENENEKQIKQISSENIQKVVAGAWNEAILTSKGNVFAKGENINSKNPKEFINISSLIEDPNDRIIEDIVSGAYSIYLLTSNQNVYGIGSNRRYQLCYDLGTYTETEKPILMIKNVSKIFSGIISSSVFLLSPNQELFGCGNNQFGQLGLGRTRKDIIPRLLQLQNIPKGKIIDIQSGLTHSIMMIENENQNPKRKLYSCGLYRYNGLGRNENAYEFTEIKSSLFENDDNILDFSVGNEHTLILTTKGKLISFGRNDYGQLGTGDTKHQSIPIQIELPKLRFNEDISNYHISCGFNNSFLYYSPISFFSNLEEDLIKLFERKEFCNVSFKTKNERNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXG5</accession>
    <name>A0A9Q0LXG5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-coa mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000008">
        <property type="protein sequence ID" value="KAJ5080545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXG5"/>
    <dbReference type="OMA" id="WMWERID"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03114">
        <property type="entry name" value="MMAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006958">
        <property type="entry name" value="PRK09435.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408:SF3">
        <property type="entry name" value="METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03308">
        <property type="entry name" value="MeaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="416" mass="46592" checksum="C1DB55DE5B29B0FB" modified="2023-09-13" version="1">MQKQLISKINFPSRYFSSLLHSSILSPLKFDKNDNENREKEVNKGYQFGISKQIESTKPTQKTQELAQSVIEGKRYSLSKAITLTESERIDHQIQASHLLSIILNKRNEKILNRKKISSNQHFSSSVNRSDLMFNSNSFRVGITGPPGAGKSTFIEALGVHLCNLGFRVAVLPVDPSSKLSGGSILGDRTRMEELSRQPNAYIRPAPSNNIVGGVSLHTFDAIHLCESAGYEIILVETVGVGQSEVAVGDLTDFFLLLLPPGGGDQLQGIKKGVVELVDLVVINKCDGDLVSAAKRIQRDYQNALHLLRPKSLNWIPEVLLCSSFDENSVAKVWETAMKFRSNLIKSGEFESKRKDQRKIELWTQINQLIIQNLKERKNVRNLLRNLDNLVSDGILSTREASFKILDSFFEDVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXT5</accession>
    <name>A0A9Q0LXT5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000003">
        <property type="protein sequence ID" value="KAJ5080725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXT5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="163" mass="19675" checksum="07D93E39F4BECEE3" modified="2023-09-13" version="1">MKIKIKNQNQNENQIENQNQIQNQIQNQIQNQIQNQNQNQNENQIKNQNQNENQNQIQIQIENENQIEIKVHKLMLILRSDLFKGMFQLNISDSSNQVHDYSKKSIETIQNLIYFLYHNKFDKNKKIKKGIIEEEYSDLKDYYQLNENSIIDLILEKKKKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXX2</accession>
    <name>A0A9Q0LXX2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sca1 complex scaffold protein scaa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000005">
        <property type="protein sequence ID" value="KAJ5080641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NFFDYEQ"/>
    <dbReference type="OrthoDB" id="17150at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037474">
        <property type="entry name" value="ScaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516:SF1">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1293" mass="151435" checksum="36A6DC53EDD8B6F2" modified="2023-09-13" version="1">MSKKVSKTTLKRKKTISNLSNIVLQSDSTTSLYSFETRDKKTYSGPDITPFHIHDHPKTDNRKFPVYYDIEGNYYDIHYRRVSQELVTRNELEKTKLETEKNLETELSNAQEDDIEFIRNKNSALISNFPDDLQDIPSFPKSQGFSSFDDFEQALIAWKNKITSRFGFVQHPIYIGRSYPRPYLAAEQSEKKQDQEERSSVTDSERMSTDSKRTSEQIPRTSSTSKDSPRTSSIGKSKIIETAHIERRHSTIDEHLDHFSQKKMDKLPDFMEGTSLFISDKEQWSNKLIPPEPKPDNYSSFEEFEKAFQRWSQIVMGTLPKIPIHSRQLSEIYGILTEKEIEEKETKRRKEENALIFIERVKKTKKQIPEIDRYYYWMKRLNYSFFTSLVSSGILSYDYLQYLVYKKTKEEILSEIEIEKQNQEKMEIMNREKQKKLKNLEKQEKEMVMKLSMTQEDRSNIEQTTFGKDTPKVNLSEEAIKGVQNFFSILNEKKEKNFSFYRSFCKPIIGKIHGTLPKSDLAFQQQKLATEQKGGLLQTSRASLYLRRTDLTGPMINSSMDCPSEVDGKNVLFAVPPYEISDAFDFEKIYNEQSRKATISQISKVDNQKRLDQIQFWYNPAKYSLEKFNEQKIKINQLINQSSDKFTIDTLRQILCIEMCLDQFTNLLSDYVIFKNKQVPYSQVFLSCITADNFSEILKIFRETTSFQIHAQLAQFVSETLQAGISKQIIEKYVREHDVNNLYYMAYAFNFLEDSPIPIFPQDSEVLYLSKKHFSGATLSLEKSIFTHYYLSLIWKGLNRGNQNFLFVNVNSQIQQYLKNLKNSFGMTIQSNLQFLRTDLFKAIESSSIKISGYYLLLLMFLIKAEDKVLDEILQSKETALIDKIKYLTNSKYTHVRFSCLQIWNQLLTFPGWTNFLVNYYTENIEVLLKEFTPPLLNDFKENEEEDKKARFMLVLIDNLFEVVFEEIISKSNKESILINPDLYFELIKKLETYIRENYTNSTLIYIGKFLRNLVSSFSSLKLIDPISKEDKTKIVTSQFKKKLRISEEDCLRILSIVGKAPHSLDQMKTYLIEIVCDLIRPEGIFEIIRSSTGFFPQFISLFRDCKNFELSDQFWRLYYETILYHPNVVVHFKKINHLKPMIELISTSSDASITVVGLQYLYKILTMDQKEDRRIQRGESSSRPFEKDSVKKIAKDVKAFADFFDKNALFVKIHMIYMNFQDKAGIKYGGKKFINLAKVYEAIMTNPSCSKIAQTGLKKSDYKEGMELIHSFFGIDEKQKKSKKSGKRGHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R459</accession>
    <name>A0A9Q0R459_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 33a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000142">
        <property type="protein sequence ID" value="KAJ5066462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R459"/>
    <dbReference type="OMA" id="EFHIFFV"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="593" mass="68434" checksum="2869DE130FA508F4" modified="2023-09-13" version="1">MSGAINLENSRIIKDLGLIRDEIQQELFRILDSIEGPKGIVFENELMIPLGLIAEFHSLKERLVQNVFSLNSDPIRTKLKTLIFFVRPKMKMMDHIAKHLRFHDTEDKSQKKRCFIYFVPRKTFICEKLLEQAGVKGAAVIREFNLDLIPLDHDVLTLGLETSFKEFISGDTSSLYYVSSSVHKLQRFFGLIPDIKYVGKNGKIAGEMLLRMRRESPIDENIAPKINHVIFIDRNVDLVTPVITQLTYEGLIDEMYTIKHSYVELDGSFLGKDNQTKEKYALNSNDILFEELRDLNMGEVGPFLSQKAKKISQDYNSRHDLQELQEYKVFIGKLPTLQKEHFSLKIHLSIVEDILNKTKDDDQFRDKIDTEMGILINNIQANDTIQNMIYREKPLEDVLRMLCLQSLVNNDFKSKSFDNFRREILETYGFQHIFTLANLEKIGMFKKSEGRSKTRFNFNQLKKSLNLISENFEETKDISSVFSGYAPITVRLVQKAFSSGWQGLEDSVFRYLSDGVFGQFSQENDLSNSEQSMISEKRNVCLVFFINGVTFAEISALRLLSQMQDHSLDYIVATTHIISGKSLIESAYENFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4H6</accession>
    <name>A0A9Q0R4H6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras and ef-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4H6"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="175" mass="19932" checksum="26AADA7AF23D91FF" modified="2023-09-13" version="1">MNPKFSQPKVMKLLLVGDSLVDFTSLDVEKTPIKLQIWDSAGQERFRSITRTYYRNADGIMVVFDLTNTSTFKQVSQWFSEISSYAPKHTNIILIANKSDLTDERTVSYEEAKKIADEHNCKYFEVSAKNGENLDEAFKTLVADALENFKKIQAEDPNYVLRPTTDVAKTKKGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5C5</accession>
    <name>A0A9Q0R5C5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radial spoke head 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5C5"/>
    <dbReference type="OMA" id="EIKGIWE"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="443"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="509" mass="60102" checksum="C2D71460DACBAFEC" modified="2023-09-13" version="1">MNLIRRTYDDGSIYEGEFYDEMRHGYGSYTFYTNDFYRGNWRFDQKHGKGVYIFATGGIYEGDWDNGRKTGQGVFIFPSGDQYTGTWKDDKRNGFGIYQYNNGDRYEGFWFEDQKHGLGYYQYASGSEYIGEWTKGIKAGFGRFYFKIGDIYEGQWQEEKRNGWGIYLYARDGDRYYGHWRSDNKHGLGTYIYQNGDWYFGIWKDGEKEGIGVFHYAESDSQYIGFWHRNQRHGFGIYYFASGDIYKGYWKMDQKDGKGDYFYPNGDKFQGEWRDDQKSGLGTYFYGTGEIHSSKWRNGVKHDPFAKIFPIKPANVVIMKQFVNGIPQTQSEPIKCNPKEKPEFEYNQFQTEEELLRKRLKIADLKLSHPKFIIPRSIAIICSKVILSSRFSAPRFHLLMNPEMFPIETVDVYYWDNENCLNINLYNQNILEDYLKNKPLLDWSTEDVETWLNIIGVPNLRDLLRQNGVDGKSLSSFDSIMMKNFGFREIGYRIKIIQKLKAIREYQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5X0</accession>
    <name>A0A9Q0R5X0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras guanine nucleotide exchange factor i-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5X0"/>
    <dbReference type="OMA" id="YWETELY"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF366">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="472"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="631"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5068502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="864" mass="101269" checksum="FC3CE6A160D2D8BE" modified="2023-09-13" version="1">MKIKINKIKLKTNQNQQNQNQNKNQNENQIENQNQNQQNQNQNQNQQNQNKIENQNQNQIENQIENQIENQIENQNQIENQIQNENQNENQIENQIENQTENQNQNQNQNENENQIQIQNQNENENETENQNQLQSQIQNYIQKPISFPKLKPKSRLAQEPKFKKESKSKSKLKPKSKSPQRNNPKKTGSDQESKKESISQTFSKSNEINNSLDKKLNRNTLSIFTSKSEEIKQLQQTLSDNTKISKNWDKQQQHVENKTPKIHQQAKLTRGQTIDVYNKKPSVTLNLPNEDNIEEKEKIEKEEKQETNEDQKSEKQIPKNEWFATVLRNHPDVLHLKEKLRYLTNGESFGKLIQIGFTESKESLQKRIMIKLIMEHLQLNKFHKTLKSLEIESQFKSEFSSKKKSTLKTLLTFSLQSIEDIWNSNYPMQSLSLDPEVNIIPEFNSFDDEDSQNDVPIWNEPPDSEENIIFTGERIRAANLNKLVEKLTSERALDLKFVEIFLLTYQSFTTPQKLFQKLVERFNVYTNKEKTKEIKQMNLRIQLRVANVIKNWIEKHFTDFDDALLAKINNFISNELPKANLSSLSTQIRNLITKKIEGKESESVNFLEIPPEPKIPKNIFSKNLSLIDVDEEEIARQITLKDFEIFVEIEPCELLNLAWSKPKLKHRAPNVLKLISQFNQISGWITTEIVSGDDIQHRVKLITKFIRLAEYFEKINNFNGLISVVSGLNDASINRLKATWEKVQPKNMSSFERIIEAMKPTGSYKNYRNILKNVNPPCLPYLGVYLTDLTFIEDGNKDFVGNLINFHKRFLVGDIITQVQQFQQKKYNFQQVYQISLLFENLHIISSKEAYDKSLIIEPRKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R628</accession>
    <name>A0A9Q0R628_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R628"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="590" mass="68876" checksum="6922D9CF550760A7" modified="2023-09-13" version="1">MNEILFFGYNKYPILIKNETNIIIKKPIQFKFENENENENENEKQIKQISSSFFSTIFLFKNGKAIEYLKDSNQNPSKIQIEENIQKVTVGYQNEAILTKEGNVFAKGKDIDPDNPNEFINISSLIEDTNDRIIQDIVSGENSIYLLTSNQNVYGIGSNELGQLGLYSKTLNETEKPILIMKNVSKIFSGIDSKHVFLLNSNQELFGCGYNEYAQLGLGESRKQETKIQKLTKIQNIPKGEIIDIQCGTSHSIMFIENQNQNPKRKLYSCGNYRFNGLDKYKHTNEFTEIKSSLFENDDNILDFSVGNIHTLILTSKEKLIGFGNNNFGQLGTGYTNEQSIPIQIELPKLRFNEDISNYHVLCGYRRSFLYYSHPSFSNLEEDLIKLFERKEFCDISFKTKNGEIIKAHKLILKYRLDQNENQIEKLKEIISKKSIKESNQIFEMIYSNNSKINPKLYLEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIEITQQIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7D3</accession>
    <name>A0A9Q0R7D3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7D3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="97" mass="12051" checksum="97F304A4BA994281" modified="2023-09-13" version="1">MLFEDEEIVKLFDKMIYLQVDTDEMFQRRMARFDEPHYYHLENEEPSEDWKERYFNEVVKIEAPKYSTCRNYQVHFIDAKLTQEEILEESLKYILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7I2</accession>
    <name>A0A9Q0R7I2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26s proteasome non-atpase regulatory subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7I2"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="78"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="264" mass="31537" checksum="4A12A2ABDE948D2D" modified="2023-09-13" version="1">MDFNELYRLLSSFTNSVENDFPDFQYCNELLTQLKIQLAEQNILFSSKLEKQNIEGLKIARQTLEFAVILSVKMKENKSFERHISQLKPYYYDYENFLEPSELKLKILGIYLLFLLSQNRIAEFHTELELIKIEERKSKFISFPMRLEEFILDGNYFKIREAFSEKPSELFDFFLEELILSLRSQIAECVQVSYPHLKVKDAFEILMLKDKNDLIEIAQQNDWLISEDDTIHFKLENDNENVQIPSDRLIREIITYAKEMERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R813</accession>
    <name>A0A9Q0R813_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26s proteasome non-atpase regulatory subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R813"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="318" mass="36824" checksum="8D5B039D2EF3937D" modified="2023-09-13" version="1">MSYTTVVVHPLVLLSVVDHYHRIAKDTRRRVIGCLLGELTTKHTLHVTNSFAVPFEEDDKNPKIWFVDHSYLETMFAMFKKVNAREYVVGWYSSGPKLRPTDLQIHEMFRKYAQDPVFVVINVHMNEKELGIPTQAYRSIEEIKGDGKISHITFQHIPSEITAFEAEEVGVEHLLRDITDTKSTSLITTISEKINSLKGLEKRINEIMNYLDKVLEKEIPDNQEILGKIQDIFNIALNLDVQNLFQPIAILNNDQTLIMYLSSMVRAVLALHDLINNKIANKRLEFDLQTKIEEAEERKKNQLEKLKENQKEVQSNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8C7</accession>
    <name>A0A9Q0R8C7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8C7"/>
    <dbReference type="OMA" id="LEVHWLS"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF177">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040547906" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="21"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="553" mass="65119" checksum="B91FA1C3B67E830A" modified="2023-09-13" version="1">MKYFSLFIKISFLIFLFVNAKNGASHNNLIYINKIASKFNPHQVYSLDDFQFCFIDYESPKEDQSLSEIFEGSHPYQTLFQIPFNSEIISTEICKTSINKEIYSHLEKAIKDNAYFEFDFNGLPLTIPIGNSFIDNDQSTKLNIYRHFVFKFYYNKDQVISAQIFSDSESKMSLQTLKSQGRTEFYISVFWIPTEYTYENRLELYKSKINLITEEKIRWISVGSSILLNLFFIGLIWLLTRKIWKSKYQFSQNKDLEDIEDSSGWKAIYGDVFRIPENIQILSSFFGIGAYFLIIIIFLLIFVQLTPFMTHFQGYMTKIVLNIVLTTLLFSLPLFLIFLTLNFFAFLYSSEITLPFSLLFKLFLLWIFVTLPLSLLFGLIGKNSKATLDVPCRVNPRPKQIPDLPWYLKTKMSILISGAVPFSIIHVELFYAFSSFWTIYIYGYQSTLFLSFLLLIISVITSVVLMTYLRISAMDYNWWWKSFFNGGSIGIYIFFYSFFYYFFQSTMNGFLQFLYFFGYSIIFSSIFFLLFGSIGFFASFIFLKKVYQEIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8Y9</accession>
    <name>A0A9Q0R8Y9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Repeat outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="CLESAYY"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1507"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1531"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1671"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1726"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1776"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1802"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1832"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1864"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2048" mass="232517" checksum="84DD758998AB33F3" modified="2023-09-13" version="1">MVKKQFIYFTLILFFQIIFLNFKINCNLPFPENCTFDDPNTYYLEAGKEYNFSCILEQGTDITILCKDYLNETTLFYVDIMTEAGKNIFFDMQNCGPNLTFGLNISVDNFTNLNFSNVYFNSSARISANSSSLNLNNCSINGTNEFNEDEYFIETLDSTVVIEMLNNPNPSSFPNLLFKQEFNITSEVTVTYCDENFNFTLDGIQTILTNCTPLELTINNTHLTLADNYSEINNLIIDNSDFTISDLVVRKLSLYGNSSISAPFVNVNESLFIYGSSSDSKGISTYLYFNGTVFASEETEIEIKNRLTISSSACNYETTNLTFLVNNGVLEINNPITIKEIEFNGLSSLNGTGSLQILDFIHFTETGDKIISASLKILNLSNSETSIPFDGFVLLYSDFFINTSLDSVMLPSLKLVGPETNLKLYSEVSNTNYTVPFLRIDGGSITGNETNFLLVEDKTNFYNYSVINYIQIDSNETSLFGIGSINFQNSARLYTSIANSESGSNFNLFGSGFFTTELLNVEGNLSFDGILNPKNIEIKENAILEGIIEEYYFSSVNVTLNGSFIIKYSSLDNVFDSFICYSQNSFPLTLINSDMHFGENQFALPPLKMTNSIISNFSSILQGLFLEGSNSFIDSSITFENGLIQSKEYAYSFLDLNSTTLNFDDYSGLNLSSSSSLRIFSSDYTTLNLFYDGVTNSTFSVSNDSSLKLENIRLEVNGDSVLDLNGTILVNGSYLRIYNFNYKWIGNLEIINSSSEVYLESSLKMKNLSFSQGKLTFDHIHASDYNSSLIFGDGKSEDAIVNENKATQATIYSLGYIEINNNTVFNKIGFDIQNGSLVINGANLTDPSYQSNITNQGEIKINPNIAHELNEKQDGGYLDEESSDFYIDFSVQNQGGIIRCYQNVRFIRMLTSSGIIETSNNLTFENGLDLWGTGKIQGLWGEKPNIFINESLYMHESSQIEFFNIYIDKSFSVSGSTNKSIIDSNLTAKSFYCDFGAQFHLNGSIATIQEDYFFNYECFLTSSTYSYSSEFYNYGNFFVENLISISFDVDFFSYGNISADSSGILFKKLKSYGDFQLNNSNLTLLEDSFLDNRDIDNHPGVTHLTQSIIEMRNGKNMTFLGFFIIEDGLSVLGNFQMNESSNVTLKLKNYDSYLLINEPSSIDWEISLNLLSESEGGVRNEPYSVIKFNGSSNFSQDQLKTFDEQYIEFSEYGDYLIAKVKGCRKGQFSQSFDQKCFPCDNGTYNNQYGAFSCNLCPIGYFSKDKGQEECQPCDPGSYQQERGKMECSLCSQGTFSSQNGSYYCKECPPGQYNTINGSSSCEICGIGNFSDNPTRCEFCPKGTFNPQEGSFLCYPCFMGTYNDLLGQRFCASCGRDSYQDEMGKETCKGCPANSETNVYGASDINDCLCSLGFYGIASEACKTCPTGSVCNDVGIIVPSAEEGYWHSSSDPETFLECSVKEACPGGGSNNCNKELGYSGNLCSVCLKGFYKFGEQCMKCPNNQKNRLIIVGFFIVFLCLFLFIIARKIRNYFASFSIMFSFLQVLAVISGLKLNWPDSIESTWRSISIFNFNIDYLAVECSLSLTYTQKWILCMVFPFILLIVLLLVYFFVFLHSKIIEKCGAGFMRKFPRFCSKPSRKTTNKYLFIFSWLRFKISQLFTHGFGKEQRKSLYNNLINSYSTILSFIYLFLSYKTLQIFDCKKQSEGTYTFGGDPSLFCYEQWWKDIFPWAIACIVLYVFGIPFVLTTFFFVSSKKLDEQTFDLRFGLLCARYTKTWFFWEIFVMIRKLFLTIAQIFLSFDSIIQSVVCVIVLLFALVLQIHAKPFISDRHNTLEFVLICFSEIILFSGMIFVSNDLEQSSARGILATIIVVIIWISFSTLIIMILFEIRHRLRVHKGKDVDEIKESINIASGQTILKFLASNPSFFLVWDWILESSDHKNKLQREFFHQIKEYYDSKETEKQKLKTEQFWQKTLTKWRDSFYVILESWFIQASLQEKIQFINILTKIRFEGLLYGNSNFTQKERRRTRRLSVKYFKKNLVSNPSKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R962</accession>
    <name>A0A9Q0R962_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R962"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="86" mass="10312" checksum="B2F2A47404BB30B7" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIETGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9X8</accession>
    <name>A0A9Q0R9X8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fam11a b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9X8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="299" mass="35233" checksum="B33221F1E42E167E" modified="2023-09-13" version="1">MMRYIQSIPNPGNELISKSKLIDQKFKERKQKFEELRKNQAEMNRKYSILRKFENLIISDVFFFIFCVLTFLILLSVYVDANLSSNPIYILIPLFIPILIFSSLLLLKSFYDFDYSKVFDRVTSGIAFLLFIQILMIGLKSGKIIQISWLFVLILILIFVGILVLITIGIFYNQQNYYNFFLLFTSSMIFLFFIFLGLKLDGTIKQSYFMVFSPLFLVDLVPCFICVLEYVNNNFRHNDFILLVVILSVVLGPFIIFEILIFCYLQFSGFKYISFTFIPFYLEILVIGCCLLFSRSFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA07</accession>
    <name>A0A9Q0RA07_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Style cell-cycle inhibitor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA07"/>
    <dbReference type="OMA" id="MFAMYLD"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="355" mass="42962" checksum="F5A4347B8F4F5DDD" modified="2023-09-13" version="1">MESKDINKHHRNENKHRHKHKNEKQKKHKHSKSKSKSKSKNKDKNEHKHKKHKHSKSKSKSKSKSNSNLNLNLKLLNQIPENFVPISKENYFNKHDEFAMWLKQEKNIFFDDESSKKTHKLFEEFVEEWNSRKLDPIYYSQIDPLILRGQRTSHKWNIKEDPKLKSGEFDNIVEQVKYQSNLTWDEITGKKPNTKRNDEFNRKNRFEETNKKFESNTQSNQKNLSESDRIFAEEEQRIQQSYLNRMNRKKYTEQKKVELEELVPKKTGIERTRELKKIKSEYTRKREDSPEFDDNFIFGQDNFNSMLQKRKVQEVERKKQKEEDLAAKVLEYQQQEKEKVNSLLESLGLKPDHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAH5</accession>
    <name>A0A9Q0RAH5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAH5"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="441"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="513"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="548"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="585"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="621"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="659"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="696"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="732"/>
            <end position="767"/>
        </location>
    </feature>
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        <location>
            <begin position="768"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="804"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="877"/>
            <end position="912"/>
        </location>
    </feature>
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        <location>
            <begin position="1125"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1236" mass="144417" checksum="B2E25FE30441BBE3" modified="2023-09-13" version="1">MENQELNNLLIRACKNEYKYKKQSSFETIKYLISKGADINTKNNDEKTPLHLVCQYQKKNTLEIIKYLISKGADINYKTNNKETPLHYACGYQKQNTLEIIKYLIEKGADINAKNNKETPLHLVCKFQKENTLEIIKYLIEKGADINAKNNQEETPLHIICQNQNEQNTFEIIKYLIEKGANINSKNNQETSLHIICKFQKENTLEIIKYLIEKGADINAEANYTKEIPLHLVCQYQKENTLEIIKYLIEKGSDINSKNNSGQTPLHYACQIQKKDTFEIIKYLIEKGADINAQNKYNQTPLHNVCRDQKQNTLEIIKYLIEKGADIKNYVNEGPLHILCQYKTENKTEIIKYLVEKGADINAKNNKDEAPLHIVCQYTNQKENIFEIIKCLIEKGADINIKANNKETPLHYACGYQKQNILEIIKYLLFKGADINAKANNGQTPLHIICQYKNENTFEIIKYLISKGANINIKANNNQTALHFICQYQNENTLQIIKYLISKGSDVNDLSKYNQTPLLYVCQYQKQNTFEIIKYLISKGANINSKTSEETAIHLVCMYQKENILEIIKYLIKKGVDVNSKAYTNKETALHIVCRNQKQNILEIIKYLIKKGSDINIKTNKKQTPLHIVCQYQTKNENILEIIKYLLSKGLDINAKANNKQTPLHYVCKYQNKENKFEIIKYLISKGANINIKANNNQTALHFICQYQNENTLQIIKYLISKGSDVNDLSKYNQTALHYVCQYQKQNTFEIIKYLISKGADINAKNKSNKTTLHYTCQYQNKYAFEIIKYLISKGADINAKNNDEETPLTFALKYQKHKETIKVIKYLIKNGADVNAKNNFNVSILELISKYQIKNYFEIIKYLIKKGLDVNAKYKNNRTPSHIICLNNNEKAVDLMKLLIEKGADINTKNISNKLPLNYAIQNKNQELIKLLIMNESDIPDSDTYEITKEIIDLFLKTYSINQDLNNLLNSNDNLSDFEIKTNDSFKFKVHKQILLLRFDYNQSNLQKFINNCLQKPKEIVEIAINFIYTGFPNFDNFIQKFQNLKNYLIKIKKLKKNSSKKKLKKQLKTKEEELKIKETKQNEINEEFFKEIGLNSNWIKSKSKRKGIIKDLSKLYKENNSKKDFTIICEEKEIKVHKLILFLRSELFQGMFQLNIEDKSNQVHDYSRKSFETINQFIYFLYHDKIEENKFNSKIIEEFEDIKDYFQLNQNSIIDLFLNDLISSNKFKNTKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAM7</accession>
    <name>A0A9Q0RAM7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyadenylate-binding protein rbp47c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAM7"/>
    <dbReference type="OMA" id="DYAPERN"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="117"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="271" mass="29640" checksum="2E1DC7E7EC29D2D0" modified="2023-09-13" version="1">MSEPISLFVGDLPQTVTQVYLKQLFAERYHSVIASKIITDTNTGQSKGYGFVTFTNDEDARRALVEMNGFFLFGGTIRVSTAHSKTSLIPNSTPTFPALSTTPATPTANITGDASNTTVYVGKLDPTVSVEELKSHAEKFGEITYCKIPPGKGCGFVQFTTRDSAENCLNNLTGQVIGCHPVKCSWGRIQPKTTTTTTPTIQTPTNLTNVAQRITIPQIPSTPLILQQTSVEEVLKPLNIEEENSKFSEKKLKHSTLSLSSLYPIFNIFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAQ6</accession>
    <name>A0A9Q0RAQ6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAQ6"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF122">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN SKYWALKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="152" mass="17792" checksum="26486DA8E6DA0D16" modified="2023-09-13" version="1">MKLRFSTKKEEFDCKKWHSKCDDKGKTLIIIKTKDNYIFGGFTSIGFKKDKRWIYDSNSFIFSLRNDKNDRKPEKLSIKKGQESNAIYSHSDYGLLFGNDIYLLSNLQPGYSNTGVYYNIPNEITPRSNEAKNYLTGSYNSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAQ9</accession>
    <name>A0A9Q0RAQ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Germinal-center associated nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAQ9"/>
    <dbReference type="OMA" id="YELCERN"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="67"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="435" mass="52326" checksum="5B6EB3D53096FCF2" modified="2023-09-13" version="1">MENKKSFNFNKSKNFQFKKRNFQFKKKRNSKFKNRKLKFTEENINDQKNNKKNNISNNTLKGTCEEMCPKNEYILRNRIKDFSFFETDIKTLNTKTPKMDINLAVKKYPKTGKKPDPKNIRTLATLNNTMNYLIDRILDREDRSFHEVYSFLRDRIRGVIQDVTCQNIRGKYAISIYEQAIRFHILSDYELCERNQDEFDQIQNTDLIMKYLISLMELYDFNRKNKENQNQNQNQNQNQNLNLNQNQNQNNINQNEAEFRAYHLLIVANSTEINYLNIPKEILVSEQFQFALEIYSHFHNLNLFQFFKLKNKSTFLQMCLINRLSNELRINGIKILKKATYYSRCKWFPIQDLLELLGFEQKKEMIIFLNSIGIKEMDEKSVNIYQFNSNEANFPVCLRFFDFKLLGLKRSDIIKKEYKIIISSKMKWIEENSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB36</accession>
    <name>A0A9Q0RB36_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB36"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="140"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="613" mass="70953" checksum="89369E7B57DD8FAE" modified="2023-09-13" version="1">MDIEEQQQEQEQNQSQNEQEIEQNQIQIQEQTNSKWKRQFTPGLPTILPTNLPDDILQAIALRLRLEEIHRQIHLNEFDINEVLRGEEEPDPIYDTNGKRINTREQLAKDRLNEEKQEIIEKITALYPNFNPVGYRPKPTKKILKIYIPQKQFPEINFMGLLIGPRGKTLKQIEGKTKTKVSIRGKGSMKEGKIKQPYKPDDDDDLHALIFGDTDDSVQKAASMIRKILKPIPDEHNELKKQQLRELAILNGTLREDYAINPVFQRLPNFPDQTGFDSAMQSQRFDAEYESLISQLNSEIAIAEKKSNPKEVSQTTMQINKGVNSNQINPMAQNSLQSQQILQRSSTNNPQQQIYPQYSAQNVPIHDPNNPGFYLQQNLMKPLNQPKQGIEESQFNEQKMKAIQALQAMQANEQKNQMNQMNQMNQMTQLNQFNQSNQMNQMTQLNQFNQSNQQNQNEHSQLPFSRHPSHLQMQHPYPSQLHFQRNSPQENSLHLPNQNQQDPRYNVQNSNESTRFSQNHSHSYQSQQQQQQQQQQNSNSMISPSHSPSNSHSHSHFHSHSHSHSHHSHHSHHSHSHHSHSHSNQTQQQKNPYGVGNSTISTSHLPDAPPGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB70</accession>
    <name>A0A9Q0RB70_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB70"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="651"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1013" mass="118691" checksum="6A90CB37B5BB0160" modified="2023-09-13" version="1">MVKKISCQETFGNISFDDDTNNEKNESKYKYIIHLKLLNSQLYLTSNNERELDSWINYIQIVRNFVSLFNLIPHPILSISKMKNDQLLSYLYNIYHWIVSEIKREEEENTSSENLLQLYQEYDEFSFISLQHQLQLSYQKISHLELWKNRVLYKISRVEFSDLLQKNPDILLAFSERPSGIEIQIFKQKQGESTTHHLLPYLNYSQEKWFVLDRDDLSNFEKKGANDPEHSSQFFAAHPLEKTEKSSQKGLVFSKNIHIITPEILSFDQNTLLQFIYRQFLDLITSSIPPPVYFEGYVYFIPHHKFRTTSCTKAWMRINKNVVEFFTDKFQTKNLNTLKLGDFSIVKNIQIKIDKEVTSKGFEIVQDKKPTKIGSFKEQETTNLMAFFEKILLFRNFPISIDTLFSNDILDSGFKAYDLLINIRDWMDTQVAEFKTKLEEISKIFYQNDLVLIHPKEQEAMKKQYLSYSKALQQTENWRKIVLSYLLRHRIGKNDDNKPRAYWKASSTDENKRWFEIANVQQISDGKIDLIQEQEIKSVIFENIDIIFPIRLRDFTMEPSREKHHQPKETKTKKPKKTENPKKKEKPKKTEKPKKQKKPKKTKQKNVDPNKPVDTTSSGLSQQERESLLVVLLLPQMILPFCLLEEVNIREMDMLCKNLIFIFEYVQQPILPLLKQLIEAEIKSTTSEAVLFRGKSTAIKIISEFCGIYGKYFLEMSIKKPLEKVIEANKTLEIYPGKVESDEQLKENITELIEYSEIMLNQIFESLYFFPIVLRELNYKLFQITAEKFPSSRYVIVAGLVFLRLICPAIVAPEIFGLASSPPNKDARRALVLISKVIQSIANGMMFDLKSPMAVCNPLLEKMIPLTKKFMDRLLQPCFEVKIKEDYPSLDLKQNQSVVCLGMSDDEKTLFAKITPESHQLIYDVRKIPVEYVDIQNKDLYLDTMFESVNFESNQLEVSLKHIHSLLSNQVLFEKVNLKVNEKIALCEDSLSLKMIFTDSFKALTQLPEFKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBA4</accession>
    <name>A0A9Q0RBA4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBA4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="138" mass="16143" checksum="FCB349B7049288C6" modified="2023-09-13" version="1">MTKNFFQVNFSNACDLQFIVGFPKEKSLEEFNKILQNKPEKKRKETTDLIEENIKQKRDFQSNQNTIQMETETESEFANQIQSTQNDEINKQTEKKNPTKKYKSKSKSKPKSKKKSKSKPKSKSKSKSKSKSKIKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBA7</accession>
    <name>A0A9Q0RBA7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBA7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="159" mass="18460" checksum="A3C38F65AC84B2B1" modified="2023-09-13" version="1">MDEKRVRIKMTYGKKAKRTQFPINSTLDSLSPVTKDLTGIEINEQFFSQFSLFFQIENDNQFQFAIQPKKSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSNSLLRFLVLKKEEIEKEKNNSKEIKKLKKEIKKLKQENEKLKMKINQQIILKNLKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBL6</accession>
    <name>A0A9Q0RBL6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_00876</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBL6"/>
    <dbReference type="OMA" id="RECSHHK"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16534">
        <property type="entry name" value="RING-HC_RNF5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5074247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="323" mass="38737" checksum="90B0E322161A05CD" modified="2023-09-13" version="1">MKNENENQNQNQNQNQNQNENENENQNENQNENQNQNQNQNQNENENQNENENENQNQNQNQNQNQNQNQNQNQIENQNQIENQNQIQNQNQNQNQNQNQNQNENQNENQNQNQNQNKNQNQNQNQNQNQNQNQIENQNQNQNQNQYSFLFERPPQRYSINFAKKNKPDDENEKDYKCNICFETACDPVVSKCGHLFCWECLYMWLQKKNECPVCKNVINSKEDIIPLYGRGRECSHHKYNTFQIPKRPEGRRSKNQNNNPFANSETSQNDSHHNNISFFGFDLNFGDSNQQTLSSQERNRPDKKKLIIFLLILFYMIFFHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCC3</accession>
    <name>A0A9Q0RCC3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCC3"/>
    <dbReference type="OrthoDB" id="297375at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="181"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="302" mass="34269" checksum="1FEB052B533DECEF" modified="2023-09-13" version="1">MNDCLFFGSNKYPILIKNEPEKITKPIQFKFENENENEKQIKQISSDEEFSTIFLFKNGKAIEYLITVGYSNEAILTIEGNVFAKGYDIKLKNPKEFINISSLIKNTNDRIIEDIVSGDSSIYLLTSNQNVYGIGANYSGQFGVDYKTLSKTEKPILMMKNVSKIFSGNSSFHVFLLNSNQELFGCGDNTSGQIGLGESRNGEELKKLTKIQNIPKGKIIDIKCGSLYSIMLIEDQNQNPKRKLYSCGDYRYNGLGKTEDTYEFTEIKSSLFGNDDDILDFSVGLNHTLILTSKFKIDWIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCD2</accession>
    <name>A0A9Q0RCD2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCD2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="226" mass="26140" checksum="C9387C4EDD60CE3A" modified="2023-09-13" version="1">MGNLERSITKYSNNPNENPLLSEMNIVLKMMGKEETPIIGYQEEISEAHILTQKKWRYSGKKSIIRINFGNDKESRDTIFNFIYFFDPIKISKNSVTIQKRTYNTSYIIYMTKIDPAAIFDIMNSNRNEQAIAKFRTFLSGENVQVNKPQENLISNEIDLEEPLNVIQDFDDRNSSIPICRIERKPLPSTCCGCCDGGDWWNADYPIYIDGDGVSWKKENTTICDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCJ5</accession>
    <name>A0A9Q0RCJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCJ5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="796"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="846" mass="102207" checksum="500BB5418007E3C2" modified="2023-09-13" version="1">MIIPTPKIEKPYSFYQIQNSIKNEETRNELFSLINHFQNFLKNLIEIEIGSSFFGLAVFNNLAILIRIIQIYDEIFETHIDQRIDKFKIHSEPFYQFYYQGNLFLNILEANKISELKQFYDKFGTKQNGFGFRVTKVFSLNIQEEIQFLTSFVENEFSDDELISNFQIIISPEIKKDGFIKKEKFYEKHFKKEIHSFLKTQIEEIKQKWEKEKKYLHLGLFYETQISEGEQGVNTLKTCEYYLKYFEQNNQSISDQSIFEKAKNNLEKRGKFDKNKNLYTIQKSLKNFQQILPKNEVEQIKNELDFLKISAFHLHNSSSYLHKNTINLYQKCIKKSENKEEKIIFSAFISDLAMERKYWKTAFNFLDYLLEKSFSNEELIKKYQDLFIYNRKICLIELGKFDEIIEEIKDSDSNPYYLFLKLWAYFQKNQFNEAIKIANILRNKFNEKPFSSNKLKELENKMKLFEAQKQFNSKNYSKSYELFSQVYSEYPDSSILKIFLFKLKRLQNSNEIKLDFELKRNFQKLIIYELFCQQKEKYSIQIDSKFYSVQNLINFEEEIKKRNGLKIYKIICDSIFQTSKFVFKIVQRKEQQNQSRKIIESIESLYQPNLSPYISNLKPKENFIIDSQNHNPPIGRMKENSFSFHFTKYQNFEINPFFNPFISNQNQNQNQILIEEEKQDYFSESISQSIKIINEKRREFEENENEKYIHENEIISNIQSKSSLELIDEFCLIRTKPLIQSSLLIEYLLSDISLLEKESFRNFVLLTFFEKDYLFKQIQIESEIIKQIDKLLEYFKNFIEKNENENENENENENEKEMQKIEKEIEKEMQKIEKEMKTKTENEKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCV0</accession>
    <name>A0A9Q0RCV0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCV0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="130" mass="15718" checksum="BD927C8D34574A94" modified="2023-09-13" version="1">MNQKINIDYKLLEFIIELFPSNNNSQQISSSEEILIWMQINFYLKEPLFKCIIQTEKSNERNIEDFINMLSVALDKKPKIIFGDNQENQSKIEKEYILIQQYEELFKTIDKIYQNLKRFIQFNIIKNSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCW2</accession>
    <name>A0A9Q0RCW2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein Dnt1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCW2"/>
    <dbReference type="OMA" id="NWISANQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018844">
        <property type="entry name" value="Dnt1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF8">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10407">
        <property type="entry name" value="Cytokin_check_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein Dnt1-like N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="986" mass="113905" checksum="10BC9B32262D1450" modified="2023-09-13" version="1">MNQFFQLNVSGIENTKFIILVDKNFTIKKLMKIISETYEKTYHQKVKVKMLMNSQQADLFFGYKVNDIFEDGDLVIVKDFEIENLQTNSKSQSKSKSQSKSNKKSKLDSKSKIDLQPDLQPNTKSNTKSNTKINSKSKIDLQPDLQSITKLDLKSNTKSNTKSNTKSNTKSNTKLVLKPNLQSNKKSKLDSKSKIDLQPDLQPNTKSNKKSNTKSNTKSNTKLILKPNLKSNAKSNKSKLDSKSKLDLQPDLQSNTKSNTKSNTKSNTKSNTKSKLKSKLESKLDLQPNTKSNTKSNTKLVLKPNLQSNTKSNTKSNQKSNQKSNTKPNTKSNTKSNTKSNTKLVLKPNLQSNKSNTKSNTKSNTKSNTKSNTKSNTKSNQKSNTKSNTKSNTKSNTKSNTKSNTKSNTKLVLKPNLQSNKSNTKSNTKSNTKSNTKSNTKSNQKSKSKSNTKPNKKSKLDLQPDLQSITKLDLKSNTKPKSKNLESKLILRSESESESEFEQESESDLIPNLIPDLISISESENDFEIENENENENDFEIENEIENDLQSNSKIDLKPNIKQVPSQIDKRNLKKKKRKKSEINHQVELDQSSKNNQIKNLETKQFEINTSLQSKTKQEETNLKQKKKKPRIRVAKRRISTNNWIIVNDIEDTNKKNQNQEKNELKINSNENKTTNLRNSNEKINQIIPKKQSENLEMNNTENNLIQNEMKNIFYGEFAAILHHLKTRDEQLIKLTNTLTDLVQELKSPLKMAKQQEINLQFSPIHPLMRINEKDDLKYFQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNKNQIQNQIQNQNQNENENQNQNQNQNQNQNQNQNQIQIQNQNQNQNQNQNKNQIQNQIQNQNQNQNQNKNQIQNQNQNQNENENQIQIQNQNQNQNQNQNQNQMEKEKENQMQNQIQNQNKIQNQNQNQNQNQIQNQNQIQNQNQIQNQNQNQIQNQNQNQNQNQKSKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDA3</accession>
    <name>A0A9Q0RDA3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDA3"/>
    <dbReference type="OMA" id="SHANIGQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05122">
        <property type="entry name" value="PKc_STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001091">
        <property type="entry name" value="STE family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF2">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="71"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5074519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="665" mass="76404" checksum="C70C63BD09F0A523" modified="2023-09-13" version="1">MDEQKKVVKSKSKSKPNSNSKPNSNSKTKTKTKTKTKPKTKTKTKTNNLNEENLKKTIDLLIDTNETSDNFRIKRFIGQGAFGRVYHAEHKVTKIQVAIKEMTIQSDMVDKLRNEINLLRDCRNPTIVSYYGTVKKDESIWIIMEYCSQGSIHDIMKKIKKPLTEEQAQAVLKSTIDGLSYLHSQKILHRDIKAGNIFVTDSGEIKLGDFGVSKKLDEFNQTVSFVGSAFWMAPELIQAKPYDAKVDVWSLGITAIEFVEKKPPYFNKPSMTVLNVIPSADPPSVQFPQKYSEEFQDFLKKCLVKDPEKRASIDDLKKHPFIQKKINPKTIPMLVREVKDEIKRQKEAKLIKMGLLQNKTELDKEIIPKLDTKESDTIKKIPNEQKETVITDPRKEESNTIIIDPRKEESNTIIIDPRKEESNTVIVDPRKEEKNTVVNDSKNQEENQKNDSILTSKSSMDNSKHLKPSKTKSKKIEEKLNEESETSRDTEDSGENQENQENQENQENQENQDSEDSGEDESYTNIDTDTDTESESTTNTDSESDSDSESDSLQNDSSILTRKYSRHFVHTISSREAEQNKLEAIILSIEFPNSFSDLLSSIKLTIHNKEGGLDWMSIFSTIFFLIMLYRMDKFGWLAFLFIFGLSFMKIRKNKKKNSNRFPNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDG9</accession>
    <name>A0A9Q0RDG9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDG9"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178:SF41">
        <property type="entry name" value="ANKYRIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178">
        <property type="entry name" value="MOLTING PROTEIN MLT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="410"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="497" mass="58009" checksum="4AE03EA5E4A372F8" modified="2023-09-13" version="1">MIEKKANINAKNKYNETPLHLLCEFQHPNTLKLIEYFIENKAEINAQTKTDRQEKKETPLHVACKCNYKKTTQVIKFLIEKGADINAKTKNNDTPLHFACQLHKGDSLKIIQYLIKKGADINAKNKDDKTPLHFVCHNQNQRTLEFVKFLIANGADINAKTKFGKTPLHLITQFQNEYSFEIAKFLIAKGADINAKNKDGKSSFNFVQKIKKIKNQFIKQENDPKLINLMIENNANIFDLKNSKIPKEVVNSFFRNYSINQDLNNLFKLNDNFSDLQIESLDGCKFPVHKLILLTRLNNDESLLESFVKICSEKPKENVQLALNFLYTGFPNFDILTQILETLPDLESEVSKTEKIQEVETLFEKEEQKIALIQDFFKEISLDSDWIESKSKRKGILQDFTKLYEDNSTKDFKIICENKQIQVHKLILIIRSGLFKNMFLKVQDTSNQVHDYSGKSFETFKNFIYFLYHDEFDETTIIDEKLNQDLKYLKSFYQVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDM7</accession>
    <name>A0A9Q0RDM7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDM7"/>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ataxin-10" evidence="4">
        <location>
            <begin position="271"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="335"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="5">
        <location>
            <begin position="382"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="539" mass="63291" checksum="5D1DCC3A73A1E16C" modified="2023-09-13" version="1">MNKSSQFQNENENQNQNENQNENQNENQFENENQNQFENQNQNQFQNENENQNQNQNKNQNENQNQNQNQNQNQNQNQNQFQNENENQNQNENENQNQNQNENQNQNQNQNQNENENENQFENQNQNQNENENENVEKNRLEMEQTILQNFVNKTSNIDEKSIEEIIKLMEKYPNNENIQEKGFIILQKFIQEKNQENRDKMRELKGIEAIIKLMINIPNNEDIENNDEYKELMNTAFQDQQIKTPKGIETIIKLMNNFPNNENIQENGFEILADTSFDNKKNQNEIRILKGIETIIKSMNNFPNNENIQEKGCGALWNISNDNKKNQNEIRILKGIESIIKLMNNFPNNEDIQENGCGALWSISNDNQKNQNEIRILKGIETIIKSMNNFPNNENIQENGCGALWSISNDNKKNQNEIRILKGIETIIKSMNNFPNNEDIQYQGCGALWNISNDNQKNQNEIRILKGIESIIKSMNNFPNNENIQENGCEALLSISNDNKKNQEIIKTLNGINIIKKAIENFLDNENIQEKINFIDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE19</accession>
    <name>A0A9Q0RE19_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE19"/>
    <dbReference type="OrthoDB" id="10673829at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="739" mass="85631" checksum="AD9B0CB3A309CF40" modified="2023-09-13" version="1">MNNKRSKEIWKLKEGEEKHQFYNLIWDFGLFLCEYQGDKKITFTVLEIADLYRKKYKELPAQVDKFIGDIAELFLQIGVFAQATRRNKTNFRLNHFWKPIFESRKRLDRVNLEKGIPPDSKRTRSDRTIAMLSFLIADQLKYEPKTRDDLADNTGFSRQRICTVLSVYKSVGLIHESTEQKGNIYWNHDQSLVLPKIDKYTSYLLDLRKTRRDLCLNSLQLLQKIKLKNKSKEKKDLSFENPENYQKSIELFIRNLSHKIFQNYNTSFPSSQPIIFRDSFNTQIITYKSISEKDVSIIRIFQFFGFNTSFILNEGETPIKPSYRTQSKRSAKSKNKSKETKTKAKNKNKTKTKSNSKPKKKAKSNKKNSTNKKMQKNGSKKRKKNNKSDLSSFSQETQTHKNEGKAKGKEKEKEAIKKAKNGNSKKMILRSQKTGDTIGEKERNGYGNMNYMNDMNDMNELTYLGDINQIHYMHNVNNNNNVNNNVNNNNNTVRDSNYSNQNNQNTRSFEQQKQNFTQYQNQNSNNQVAIKMPSFSSRVSDPSQINREILGLSDEPLEGEMNKFFPSIRTQNDSQIGYTPSPNIEKILPFDLNSPETTINHHSSHNPSTNHTNSFPSHDLGFSGDHPRNMFDSSKPKNYFSMMGTTPPPHFQMNSNPDSPFSPSPLSFHHRQDPQYSFMTSSISPNFLLSTSRVSPQFFFSIYDPIPSPFQLQFPPTNSSENSNISSGNENSRKKAEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RED6</accession>
    <name>A0A9Q0RED6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear pore complex protein nup98-nup96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RED6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore complex protein NUP96 C-terminal" evidence="1">
        <location>
            <begin position="164"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="559" mass="67079" checksum="716E1D44A62346DB" modified="2023-09-13" version="1">MQKIRFNSSFKVSFTFDGKIIIPINPKNDKISNQSIPKKISIYPKLILLDSFSKFIQNKESLEKIKQFHKFYFESIERMNLEQFDYLSKTHLDFLDNFVKKIEEKSELNQYFSSIQKIWELLYHFINRENQNEPNSFSTKKISNFLKQRIQKNFQKINHPNYFQKIYHLLITNQFEKACKEAIINQEYQLAILITDYFDNESQKLIANHLNFLEEKQTNPKTKIDDYLLKIYHLLASKKSEKINDLFLTQNVIWEELLAIQIWSSPSNYSISQILSIFVQNYQEFFKKKETQIQTENIEIKLIQILLKKSIDLNDIKPLNNYPNSFIFQLEKCLADNSITFHKKKENQIGNQIAKSARNYLLDLQSLGLWNQSFQLAISLEFHSLIQSMIYWDYSQNFFQIDSHYLKENIESWKKESQKIHQKIQNQKISDLVLSQNLQKSLILNQKNEMNELIILVKKEKTHKFDPLTKLILDYFKLKFDKSIPSPNIELVKEIFNKLKIISTPENDIQKQLCLKLIKDKCIKYCFRNQFQIDKQFISENLIEYLKFQRIKKETWNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REN6</accession>
    <name>A0A9Q0REN6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secretion-regulating guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REN6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF70">
        <property type="entry name" value="SECRETION-REGULATING GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="717"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1176"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1229" mass="142396" checksum="1AA1B81066C52F0D" modified="2023-09-13" version="1">MIYSNKKINPKLYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIKITQEMIDEIKIGIDYFQLNQTNPNLFDLLIKKFNYQENKKKEENQKSKILLNQLKKNNPNFLNLLLNQFNNKNQNQNQNQNQNINQNQNQNQNQNQNQNQNQNQNQNQNQIQNKNQNQNQNQNQNPNTNKSPLFGNSNQNPNTNKSPLFGNSNQNQNTNKSPLFGNSNQNQNANKSPLFGNSNQNPNTNKSSLFGNPNQNPNISKSSLFGNSNQNPNTNKSSLFGNSNQNPNTNKSPLFGNSNQNQNTNKSPLFGNSNQNPNTNKSSLFGNSNQNLNTNKSSLFGNTNQNPNISKSSLFGNSNQNPNTNKSSLFGNSNQNPNTNKSPLFGNSNQNPNQNTNKSSLFENSNQNPNISKSSLFGNSNQNSNTNKSSLFRNSNQNPNTNKSSLFGNSNQNSNLSQNQDQNTNRTSLFRMNEILFCGQNQYPKLIKNKPDKLSKRTQFKFENQNQNRNQIKQISSGLFSTIFLFENGKAIEHLQNTHQNPHKIPIENIQKVSVGYHNKAILTLEGNVFAKGKHFNPNEFINISSLIEDKNDRVIEDIICTFKSIYLLTSNQNAYGTGANKDAQLGISPKTLRKTQKPILMMKNVSKIFSGNNSYHVFLLNLNQELFGCGDNDNSQVGLGESTKEKWKIKKLTKIQNIPKGKIIDIQCGASHSIMLIENQNENPKRKLYSCGDYRFNGLGKDEEDTYEFTEIKSSLFENDDDNILGFSCGYDFTSILTSHSKIIAFGGNEFGQFGIKDTKKYQLTPIQIELPKLRFNENIFNYHISCGYQNSFVYYSPFSPFSNLEEDLIKLFRRKEFCDISFKTKNEEIIEAHKLILKYRLNQNENENQNQIEKLQKIISKKSTKESNQIFEMIYSNKKINPKLYSEIKEIINLNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILAMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIEITQEMIDEIKTGIDYFQLNQTNPNLFDLLINKFNYQNQDLHEISDESEDSFQNDNYSDNDNDNDSDSDSDSDSDLEYESMIFNLFLKELENQYRNFNLMSFQNSKPKPKPKSKPKSKPKPKSNQKPKPKPKPKPKQNPQPKPKRKPKKRPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFE0</accession>
    <name>A0A9Q0RFE0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFE0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="104" mass="12411" checksum="EF88820F2B63B567" modified="2023-09-13" version="1">MSDSLSLVKTQLDENEQFEEIQQSLIFTKYSQKLTNLLYRLNGKYLSFPDFIQDWKKVKKNEKICICSLCFLPIIEKEEEVEIESKSYHLLCGNFWNHLTINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG97</accession>
    <name>A0A9Q0RG97_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spectrin beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG97"/>
    <dbReference type="OMA" id="NTMIENE"/>
    <dbReference type="OrthoDB" id="10057795at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CH_dom"/>
    </dbReference>
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        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="111"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="799"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="910"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="984" mass="117024" checksum="F44D8F4FB59E7B12" modified="2023-09-13" version="1">MGAFQIWVQTNLSDSCGDFRSVIHGFEDGACLINLLQNLSGQNMRNFITNPTSKEDKLSNVKIALQFGKKLGLPLHISPNDIIEHKENNILLMVWEIAMFFRMREIPYGDFQPEEILLPWCQMCSEPFGLEVYDLTDGLLDGKIFCAIIAFHKPDLIQKSIFESQQKNETFKEVSRACEILRIPFIMDIEDLEKGKIDKKVTLVFLADLYHKFITESELEKLGEYIEEYQNNQILPDEMQQKVAIPLSLNLKSFLTKHPTTLKKSERKLQEKVKEIEKKHEEKIMELFNELKASEKQVNQLRDELERLKQPKQMKNEAKIETQEEKEKKEEIERQKNEIIAKNKEKISQLTKEIEDLDEQSRGESFQYALQIEDMETSAKKLEEEIEEIEKKQTKEIEELKEIAANEQKQLEAQVEELKTQAEKLEKELEEQPEPVEMEDDELDQLRHNREELERQMQDLELKMQSTQESMEDYKESRQELEEQIEESEKKNLGEKNTMENYLQEIREEIEQSKVEIMQEESREQELKHTLAKKDEELEVLKKQLEDKLENERSNEKEGKLFLFIQNLEKKIQESESRLKQFENLHMKKELQNQILNKKKNQIEQLIQKNAEFKSFTELNKKIYEEESLKLQEENERLKKQLVHQREKFEKELSQKSEEIKQYTRLNIEKEERQQVLEEEISETKSKIISQKKILDSNLEKLEEKLKEERTKFEQLQKDNVALTRNLEDVIANYNFDLESLKEVVDDTKTLIESKKKKSKQDKLLLESIDLISIKLEYEKQKSQAQQLHTDYDSLSRMLNAKIETISSHRKQIARIEENKKIKLHDLTQLENKYDILNENYQSLLRSSQTNSKSDDKEKEQLLAQLNQYEEVIQKTSRQLMFLQLREKGKNSPQDSIETSEKDQSIIFDMNIANQLIEKLRKSLERSQSKLKKVEQEKEQVDRELQISQIELKRLEEMKIKTQKLHQQNQLLVIELERLDSLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGC2</accession>
    <name>A0A9Q0RGC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGC2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
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            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
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            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
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            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
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        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
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        <location>
            <begin position="420"/>
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        </location>
    </feature>
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        </location>
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    </feature>
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            <end position="565"/>
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    </feature>
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        </location>
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    </feature>
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            <begin position="895"/>
            <end position="930"/>
        </location>
    </feature>
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            <begin position="1128"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1224" mass="142429" checksum="3ACB59D36ACC8797" modified="2023-09-13" version="1">MGQTESKQKLFEICENINEKSLKIIKSIISKGGEINIRNIQKETLLHLICKNPNEYSNEIIKFLIEKGIKINLQNINKETPLHLICQKLNQYSFEIIKFIVSKKADINSKNINKETPLHLICKNENENLFEIIKLFIENGAKINIQNNKKETLLHLICQKENQNEIIKFLIEKGIKINLQNINKETPLHLICKNLNQYSNEIIKFLVEKGIDISSKNINEETPLHLICKNPNQYSFEIIKYFLSQEIDINSKNINKETPLHLICQNQNEKSIQIIKYLLFQGANINLQNKNEETILHFACKNENENSIEIIKYLLSKGISINSETKYKKETPLHLICKNPNPNSFAIIKLLVERGANVNTKTDYYCETVFAYKKGADVNAKSTDNKTPFYFACKNKHKKANDIIKLLIEKGAVINFENNEKETALHLICQNLNENSIEIIELLVENGADVNAKTNENKTPLHFACQFQNSNSFDIVKILVSKGADVNAKTNDNQTPLDLAYQSQTQNSIEIIKFFIEKGADINSKTLNQETPLHFACKNQNLNENSLEMIKFLVEKGIDVNAKTQSNQDTALHYLCRSQEENSIEIMKFLISKGADVNAKSKNQKTPLHLICENQSQNKRVIEIIKLFIEKGADVNAKINNEISPLHLICQNQNENEYSFEIIKLLIEKGADVNIETTYKITPLHLLSTHKHYNSLYIIKFLVSKGASINVKTLNQETSLHFACQNQNEYSFEIIKFLVEKGANINSKILNQETPLHLICQNKNENLFEIIKYFVEKGADINSKTKTQETPLHLICKNQNENLFEIIKFLVEKGADINSKTKTQETPLHFICKYQNENLFEIIKYFVEKGADINSKTKTQETPLHFICKYQNENLFEIIKFLVEKGANINSKTKTQETPLHLVCKYQNQNLFEIIKFFIKKGVDINSKTYNNKTPLSLLIQNSKSDEKSIQFLLMNDAIFPYLKQSNFDFPKKFIPLLFKIYSINQDLNNLLKSNENFSDLIIQSNDSFKFKVHKLILLIRFDNNEFILSKFIKICSQKSKEEVKNALNFIYTGFFDFDSFFNQISLLSNQKQYQQFEKEKNKFEEKEKEIEKLFKEIEIDLKWINEKKGRKGIIKDLFKLYQQNETKDFTIIISKEKEIKVHKLILIIRSELYKGMFELNVEDSSNQVHDYSNKSNETIQQLIYFLYNDKFENEIPKEIKEEYLDLKDYYQLNQNSIIDLFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGR0</accession>
    <name>A0A9Q0RGR0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_03836</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family. USP20/USP33 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGR0"/>
    <dbReference type="OMA" id="YLISANW"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF86">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="15">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="193"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="16">
        <location>
            <begin position="644"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="16">
        <location>
            <begin position="758"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="884"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="982"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="101"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="887"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5080351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1090" mass="129270" checksum="62A32DB19DA99353" modified="2023-09-13" version="1">MKKTNFCYHLKEIKIKHLEEKLKQSQLIYKIPFLNCNSCRKKVEPLFLCLNKNCSYVGCYYQNMHIYEHYLASKHSLFLNLSSKNQHQNQNINQNQNINQNQNINQNINQNINQNQNINQNINQNQNINQNINQNQNQNQNINQNQNQNQNQNQKEKKIYQILNSDTEEYTILNQLRNLLNIPDQPNNTLGISGLINQGNTCYFNSILQALSSCVPLKKYLLDCTFDFADRFDSLLYHFYEYIYTVWKGNSSIIKPVSLLRELGKINKFFAGFDQHDAQELLIFLLSHFDSILSKNFRDKCHEFHPQKFQDIENREVKKQLQKEIEIELSSDSDENNQNQNINQNQNQNQNINQNQNDEILNAVPRFDSIISKLFEGTYQSSITCENCGTISKKIDNFFTLSLQIPQNKNDIEKGENEQNKNDIEKENKKENFQNPNEYDGEDDYDNYNLKSSFAPSSCLVPMSFSFSKFFNFFNFFSSETLSLEDCFTLFCREIKLEGKNKYHCEKCKKKTTARKKIEFTFFPEILAIHFKRLQYGKLWNNKIATSVSFPSKNLDLTNFISGKNNGKITYDLFAVVIHSGGASYGHYLCYSLNEYDNKWYLFNDSIVTQVSEKEVLKSEAYILFYQRKRTATHQSEHIQLYHQIVKCSQNIEKKFTHDQIQKNPHIFGLSRIWLSNLYSMYNPGQILNCDLVCKHGKLKYLNHLTKIPPKNPKIQIPIQIRNRILYVDKPLWQKITSLYGDTELIQDFTECNECMQEIEEMEKEKFEELQIMEKINPTSFEKDDFYYLISANWGQKWKFYIRSHCIDFPPPGIIDNNVLLLDDQKTLRKKMILGYHYLYINQRAWEFLHKKYGGGPEIKSVSRDIYFQNLNEKQNENEINNEIKNENNNGINNEIKNGINNENQNQNQNQNQNQNQNQNQNQNQNLNQNQNENQNINQNKNQNKNQNKNQNQNQNQNQNENENENKINNKIENQNQNQNQNQNINQNQNQNQNQNQNQNQNQKIKIKIKIKIKIKIKKIKIKIKIKIKIKIKIKIKIKIKIKIKIKIKISFNSNFNFNSNFNFNFNSNSILIPLFNKKKRKIFCFNFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGU0</accession>
    <name>A0A9Q0RGU0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase -related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000038">
        <property type="protein sequence ID" value="KAJ5079108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGU0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="582" mass="69773" checksum="2694803FE5E81FED" modified="2023-09-13" version="1">MEIELDENNENEEETFQELKKELQMIFSLGYQSETIVNCLLRFKIIGSVQTYSTAESIEIVTQLWRSYFIDATAFLKAIEILRNQNNEDMKPPIPPLFENSSHILGDEHFYETDMDNSLDNFPFLERSYEENESEIDQVFSNHTYVNENTRRNISPYSGEQRRMRREQELGDGRESQNSSQKKKCSLCFQYKSKPHICPCENEMRDLGTLEIFKRCANNIREGEKRRYIYSRCVNNASEQYLEENINKEILDWKQTRRNNNPPKRTNPTLVNMEENLHILHQENDPEVKKQKLIQNQRRNNHISNITNDNLNNDRNKSNTTTITNNNNNNNQHHYFTNNLSNNTHANNRSNYRSQRRKNIFPNQNQNQNQNQNQNQNRKHNLFQFQIQIQIQNQNQIQIQNRKHNLFQFQFQIQNQIQIQIQDQNRNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNRKSKSKPKSKSKSKSTTFLKHQKPKMKSKKKLQFSEFSEQFQQTETEEQNYRGNQNIDLVNKEDHSTYKVIQQQQQRRFFVPINAEKESSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH21</accession>
    <name>A0A9Q0RH21_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_04369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH21"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="647"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="678"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="280"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="945"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="647"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="368"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="467"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5079348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="968" mass="113321" checksum="C5348C4A8E47016F" modified="2023-09-13" version="1">MNRNYGNYQNKIRNNQSRFGSHKTNTYYKPQFKYVRKQNTNKPETKNEDSNNEKFPTKKTHFWSRNSQQKSNESKNDSDLKNDSDLKNNSDLKNDSDLKNDSDSKNNSDLKNDSDLKNDSNLKNNSDLKNDSDLKNDSNLKNNSDLKNDSDLKNDSDEYSWGDSNSDSDNDNDSDNDSDNDNDNDNSPQYKYQEKFDSKSNQKKLSSNTTKSTHLKTDENISTQNNNNTTDDHFQSQDSRNRNFSKPFNRQNNYYYQQNSRNYHYSHYNRQNQGYWNQHTNFHSDQRENPNQEHYYDHEGPPNNNPRTWKTTNSRFIHTQKPWQQANKQHDSQDQKQDAMQDDKEYNQQNENSKYDYRYNKQYDKGYNRNYNYRYNKPYNEGYNKRYNNRYNNRQYNNRYANPNDNWRARGDDEDENQYYKDPNQQEVDNEIPNDQESQEDNIENPNSNPNPNPNPNPNYQYHSDSRSYPNSRSYPNSKSYSKSYSKSYSNSRSRSPSRSPSRSPSRSPIHSPNRITEQKTRNSHNFFPSFNRNQNTFSTKFGPTISDIDDNWRDKGEKHKQKLKALTRESQIHQDPKFRNDKAFSYFTQNETFFQAHIDKSQPRKPKEPENTSSSPQNSANKNRNLAIYENAQVEISGENLINPIESFDDLDIGEIVYNNIISVGYEHPTPVQKYAFPIIIGKRDLMACAQTGSGKTAAFLCPIISQILFNGITDPRSCKDEIPQARPLCLVLAPTRELAVQTYQESLNFSQNSPLISAVAYGGTPIQSQIYEIQKGVHILAATPGRLIDLMRRNAVSLRDIKYLVLDEADRMLDMGFEPQIRQIIDSSDIPKKTRQTLMFSATFPQSIQKLAADFLQSYLFLAVGRVGTTTDLVVQTILFTKTHDEKLQELTRLLREVYGLTLIFVERKRDADSLERYLQENNFDATSIHGDRHQNEREEALSSFRTYQTPHSCRHRRCGSRSRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHE8</accession>
    <name>A0A9Q0RHE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHE8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="91" mass="10786" checksum="9FA24CBC3855A685" modified="2023-09-13" version="1">MIQKKSNQIYINFDYENLIAKTKKIIIIKEKGNQIDKYSSFHLCIKPKKNSPITLYLFSQFKNNTIKKIYISVDKIDIKTESLNRNTKKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHH7</accession>
    <name>A0A9Q0RHH7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000046">
        <property type="protein sequence ID" value="KAJ5078749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHH7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="67" mass="7650" checksum="28359BE7D49473D2" modified="2023-09-13" version="1">MQSQVITKTLAISFNQAIPSFQLLNVFGFPESVDNEKPSDLNTYSFVCDSHIINILHYVCEYHDVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RJ09</accession>
    <name>A0A9Q0RJ09_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_03824</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="CMGLQLH"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="1082"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="717"/>
            <end position="719"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="724"/>
            <end position="730"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="794"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5080339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1299" mass="149752" checksum="93EA25D9187CF520" modified="2023-09-13" version="1">MVKKKIDQRIRTLIENGIKTDYRGIIIIVGDRGRNQVVNLHYILSKSTMKERPNVLWCYKKDLGFTTHPTKRAKIAKKKKKKEFRKQIKKQTLVEPVKEDPFELFLSATKIRYCYYHETHKILGNTYGMCVLQDFEALTPNILARTIETVEGGGLIVFLLNTLNSLQQLYNLTMDVHNKFRTESHQNVVPRFNERFILSLSSCQAALVVDDELNVLPISNYSREIKPVYINSKNQNENQNENENQNENQNENDKIDVYQERFNQFQKNQRESDNHLQEIKQSLNSTPIIGKLIQITKTFDQAKSLLSFVEAISEKTLNTTISMTASRGRGKSASLGLAITAAIAYGYSNIFVTSPSPENLKTLFEFIFKGFDQINYQEHIDYEIIQASKSSMNKAIIRVNIFREHRQTIQYIQPQDYTKLGQAELLIIDEAAAIPLPIVKNLLGNYLVFMSSTISGYEGTGRSLSLKLISQLRETSVILKDDDNDDNDNKEINKNNENNENENENDNQNGNNLIRGKRKEFKKKPKKGSIERFQKIGPTKSITPSRFLREITLEEPIRYRFGDPIEEWMNNLLCLNVMIEPLENKMCPIPSKCELYYVNRDALFSYQASSESFLRKLMALFVSSHYKNSPNDLQLLSDAPAHCLFVLLSPINEQTSKMPDILCAIQLSLEGEISKKSVDKAFSEGKRNAGDLIPWTLSQHFQDNNFPKLSGARVVRIATRPDIFRMGYGTRALELLEAYYSNQITNLEEEINIEKNRNEKISLFTKLEKRKPENLHYLGVSFGLTLQLLKFWKKSKYKPVYIRLTPNEITGEHTCIMLRKLPNLQIEKNEWVENFVADFKRRFISLLSYNFRIFSPALSLSILDSKGIKQESINANELLIFFSHYDLKRIQSYSQNLIDYQIFLDLVPTMAKLFFMEKIDIQLSPVQKGIFLMLGLQHHLLSEIEKELKISQSQILALFNKAMRRFNDFFQKLLEQGIQDQNPSLKESDSHEIILKSMKPLQESIDEELEQEEVKVNKFLEQTQKEMIGIGELNSYKIDGSNEDWENALKNSDDFKSNQTIKLKIFIFSFFIFKKYNKKYNKKYIMAEVLGRNKLSRHLKSKIRVTVGKRTLVGQFLAFDRHMNIVLGDCEEFRRIKPKKGQKEIKEEKRTLGLLILRGETIVSISIESPPPQETQTTKLQSQKKPEGIAKAVGRGMPTPLVTQPSMLQGPIRGIGGPTLGVMTPQHQTIQHTIPPTIQQPFPRGRMPQMGFQQPIMPMRGAFPPRPQIPQMGIPNQMGIPNPMGMQQSRQSPQIPRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6T5</accession>
    <name>A0A9Q0L6T5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1219"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1459" mass="170160" checksum="1EAC60784C0C54E0" modified="2023-09-13" version="1">MSLRKHFSFQSENNLKPQLNSKEVNQVLSEIKKNLDIKKAREKPVLLKETKQNLEGDKISQKPIKPAKLSRSLSSVHQRPVTLAPNKGKRKKNTFILPEYLEKDNSVYQISDDLVESKLEQLLNSWDLDSNQRRIIESLSTEKKRRFLALNKEESDDLSMTTTPISDRFEFQIPAPFSNRKHLRRKKAEKKVDLIDQENISQTETQENKTNHIDNNQIENKEMEENKENQNINPNTKDIKPTSSKITGNYRVNTAVSNDKMLVWMAMYSKMFKVFSRQLMRKLKSLIGIKGIALFYFVLTCLPDSPFVYLKKVEKKKKPLQMKRVDQKASHKKRINVIKTLINLTKNSSFFSELAKKADIALINIEVESLVIPLVIPLCLFDLLRSYFPEINKPKFPKITNFQIDFVRLLEILQAQSIPKDIQICGLTLMGRITKILISANVELDDKFFINLQKFVEDLPDSSKQKLEDYDFDFDLFDKKQKELPKLEEIRKQNGEKLGLTISIPSNDDLKMDENQNESDKVSKRKNPTVSHNFSITLPDGNASPFKVTEKTTAKDVVDEFLKSVNSITEEYGIFATFNLETQPTTPRMEVQKLKSFTSFNVENPTIFDGNFIPSDSPIILYSNQNLQFRKKPPPKIDVILPQNPHELKQKHTSFPVNTLISTALAKLCFDLQTTKQEYGLLLKIPKKTIKKETKKILDSESSDSESSYEIPQLSFVSSDKNKFFKDGFSTSIPEAAFGVWMEDEKQRTFFSYICQYYVGGYIYSVFQPKPGEVTISYPILDNQSEKKIIQKEMKIIIDFTIQTKIFIKEFTKAYCNWTDSKFSLFQVIYGYDELSTEDFETDLNSENLSEDENIINQIKKNQNKKEKNKKIVELNFLSEDLPFNLQGIKVGDNLKLIQNESELGIKQQYSQMQEFFDGSLSFDDYETNRNKDPQMDLNLVLSNEKIEEIFDFEEVTIDTKNQKIITKSQYEILKKRELEENSVDNNLDKLPFWEEFGANYKSIIYEPDSQQNENNNKNNNSLNGNGNEIERTKASSLNKAIEMLVFTEENVDEFAKMFIELLTTITEDEIFLQKLFDVFQMPAINPKTNTEFSLEEKTKIQSRIVHIIILFCIVSRTTIRHETKSLIQNFIQNHLIQHKSIKFQHKEKENEKKELKNSKSVRIQETKEARFDDESTDNEMEKMIEFEKTQNEYPITKIPKSKVPRIKNIKKLTLFKISPEEAARQLTLVTFSKFSKIQTKELLGTAWTKRNKNLISPNVIETVSWFDHLANWVTCNVLLYSKMKERVKFIEQLIKLMDCLFEMQNYNDGVAIISGLQHVTVDRLSKTWQLVSPKFMSKYKSFDDLTSALGGFRELREKLSKIQPPSVPFLGYYLSDLAKIEEMPNRVANNLIFWKKRKRMFLAVKQLKSFQKIPFLFKPVEIIQNFFYDESNIFSEKEMWEKSFKIQENVPFGNFQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L781</accession>
    <name>A0A9Q0L781_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Atp-binding cassette sub-family c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_13036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="755"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="878"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="976"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1004"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="72"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="469"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="758"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5067366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1353" mass="155847" checksum="E79CD5BB38E7AA32" modified="2023-09-13" version="1">MGFFSSFTFSGISSLISLAKSKRLNFEDISTQFQNESVSELEKESKKLLKKNRFLRHSVSKSINQQFRGALIGSGIIKFIHDVLLFMFPLLIAATIEHVSDRTKDKNWGYFFVFGFLLVAFFEGLTEEFYFSLAIKTGIKIRTSLISVIFNKLLIIQQAGANVSGKLLKLISFDCERVVSYPQDIHNLWTQPLIVIAAVLLIANQIGAFSLIGAGILLLFIPINSAMSHAKETQTIMIDNISSRRSNLIFSIFDSIKFIKINSWEEPFNRKVNELRNMELKPIEKSQRIKAWSWTLFMFSLILAVTITFICYVYADNTLTPKKAFVSLVLYYILRNALVSFPQLWPKYKLIKQSFARIEQYIKSEKDQTIYENEMIADFPENINEAMEENDYHKPIRDIAPIALVNQWINVETRQNYSSKYGNRIENEDEFSDSDFKENQTDIDLIDSFSDDETDQKSEVEKLYKQAKLQVLNGYFGFANNQILKQISIQLMSEEIIGIAGTNPTEKTALLLGLLGQVKMVSGKIYLDGKISYIPAHPWFQKTTVKNNIIGSFKYHQQHYQKILTVCGLNNFIHNLSMKDETIMDPNLNLNEEMKQRISFARALYHNSDIYLIDDFSEKLTEHIRNDLVDRCIFGFLKNKSRILISNNPQILSRTNEIYVIEKGEIVANGTFQKICNDNNELLLNVIKSDKKRFENDLYRSVFITENEGNELDKLQIDLFRTKKENEDEDESLLAPRKPEMKTTSYVKLSGGYGYYSLLFFLYLVTSAGVVFSYFWLSFWTDGEWDKKRKFYTSLFAVINAAIIVVYALKSCLMAHASVIASKTIHSKLFLNLIQVPLSFFNNMGRSMIQKAFGSHLHMMDSNIISSMNFTFNYLTQLIAILITICIVFPWFIIPLVVVIFFYWRIDRSYTAVSKQLRALEVSSKNVIHSEFENTLEGIATINCFENKHHLVHQNHKTIDSNYRVLLSENEAHRWLGFRVHIIFTVIITCVAIIAVTTRGDVDTGYVALAIAASFIVSNYLGSFIRMKVELQAKTKVISSISNLQFIHKEPGLDRLENRLPFGWIKNGEIQFQDVKLGYSSDSKTVLKNVNFHIFAGEKIGICGPSGSGKSVLLSSFFRLFEPKQGTILIDDHDIQKLPPQNLRSEMVYIPERPIYIGGTIRENFTPYPLNDPRRIPDQIIWENLDKLGLKDIISDIPQQLDADISELQKLSMETQHLFSFARALTYKNKQIVLVDDLLKNVLNKKDFEIRLQQILHSYFKHSTILIVTNSPTILLRTDRTMIMSSKKIHEFDSPEKLLLNSGSLFFSFLNKLNPSIIQVYQEYGFDKLTELDIHQIMEDDFAKEIFELSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7D7</accession>
    <name>A0A9Q0L7D7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="IEYDPFK"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48134">
        <property type="entry name" value="GLYCOPROTEIN 96-92-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48134:SF2">
        <property type="entry name" value="OS04G0609100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1384" mass="159488" checksum="937BA3D6EE019313" modified="2023-09-13" version="1">MNLIKEDFKKFPTCLSNSNNPELKVEKDKFTATIIVHKTKTNNKFFKKKKNPNQATITSDETIPVNCGLFYFEVKILSIAKEGKISIGFLEKRSPVKNLPGITPYSFGYFSDTGKTFYDNSEGENYGPCFKSNDIIGCCANLLEKNIFYTYNGNLLPIAFKKFNLKSKIFPSIGLKENGSKIYVNFGQIPFIYNIDNYFQQKKQKINSKIYSYPCCDLNQAMFSSVSSFLISRGLVDTFKALNKEFFSYSTLQNSNFVENNNRAIFFSNIKLLILDGQIQQSSSLIFSSKNFNESNYTLELNLVLQTQNLIELFRKFPLNYKLIFQQGKALLLLKNHLSRLYSFSTNFRIYDKIQESSEEKLKKKKKKNISWRNSNQRLAYSSSMIRRNAFYGTFPSRGSYTNNFRSQKKNIRFFDSINSNAFKRWSQINFPKVHLKKKKRRQNQIQRNGRLIIERIEGYSFSNYDESDYDSDETESDYDSDETESDFYSDENDDDTDETDETDDETDDESDDDTDETDDESDDYIDDETDDDIDDDIDDYIDDETDDETESTSYEIKKKIKDKKEKKDKVSSKRSRSLDANEGNPFDFNPFKEDESEKEKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSDIEYDPFKEDESEKERSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSNSNSKSDIESDDIFADNEPNSNSKLKELDPFANKKSKSKLKLKSKELDRFRDQKFNKSNSNSNSKSKSKPKSESKSKSKSKSKPKSESKSKSKSKPKSSKSKPKSKSNSKSNLNSNSKSKSESESKSKSKSKPKSKSNSKSNSNSKSKSKSESESKSKSKSKSKSDIEYDDLFKEDESEKEQQKLDPFRNKKSKSKSKSKLSPKKSKLKKDLNTESESKSESESNSKSESKSKSKSKSKSESKSKPKSKSKSKSDIEYDDLFEEDESEKEQQKLDTFRNKKSKSKSKLKLSPKKSKLKKDLNTESESKSESKSKSKSKSKSESESKSDIEYDPFKEDESEKERSKSKSKSKPKSKPKSKSKSKSDIEYDDIFADNEPNSNSKLKELDPFANKKSKSKLKLKSKELDRFRDQKFNKSNSNSNSKSKPKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKPKSKSKSKSKSKSKSKSKSKSKSKSESTSKSKSKSKSKSESKSKSESKSESESDRLTYSYEYDSDLQMKKKKKKKMKKKKIKMEKMKMMKMEMMKMKKKMKKEIKKEMKTKSNTLKKKENILKDFEFWKEYINSKKIEEVLQLITFSSTNTFLNNPLFNQIEREKTYYFVKKFTLQILDQKPFSLLEQIIKHLNLTKKKMIRNKLVNSPFLSLINTEEIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8G0</accession>
    <name>A0A9Q0L8G0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8G0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="304"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="507" mass="60512" checksum="585F9986D9EBAAEB" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFQNQNENENEEESYFDFEIICEQNQVSFKTHKSILSSRSYYFKTLFKSKMKEYQENKMILKDVSSSILSSILNYFYSGKIEINLENAIQILIFSSKYLIDELIEISSNFIKKNLQFETIIDILKLSETMNLNQLLNSCYQFISENLDKFIKTPFFFELEENHLNFILLNDIIPINEFELFQSIIKWGKHKSNINQEKENQNIEKEEKEKFQNQISNIINKIRFIDFTKQELKDTLKEDLIPSQISEKLIQFQIFQNHKNETNFQEFIEKEFQNENSYIFKTRFKSSIIQEKDHIDKLREWINDDNFFLKMKLRYSTKKEGIDCKKWHSICDNKGKTLVVIKSKDNFIFGGFTSVGWISDESKWSRIYGNDGYISDPHAFIFSLRNDKNDRKPERFKIKQKRKDYAISYNQHFGPNFGGENPYKSYLYFNFNLQQGKSHDFCFNSNLKQGDSNFGHTYNLSNDIKYKTNEPKNYLAGSSSFEIEELETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8L6</accession>
    <name>A0A9Q0L8L6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Wd40 repeat family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_12330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8L6"/>
    <dbReference type="OMA" id="CDIRTNQ"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="8">
        <location>
            <begin position="205"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="402" mass="46155" checksum="0421176B0763279B" modified="2023-09-13" version="1">MRSELYRGMFLSVTKDTSNKVTDYSELNILEHQIWKDYCPIYYDFIYTIPLSFQSLTVQWLPYQEKTTDNFLKQRLILATFTERKSRDYLQVVELEIPLDDAVIDSSTYKTDGSFGNLGGIETKPIKVISRMFHPTEINRARYMPQNSDLIAVISSEAVWVYNSKQPKEKPIKLEGQTEEGYGLSWSNHIKGNILSGSFDQYVRTWNIENQNKLFSYKLPNKIGDASWHPRDANYFGAACDNGNFYLFDTRTKEPTISLQAHSEETNCLSFNPIFSELFATGSSDTNIHIWDVRNLSQPLRKLKGHSNGVFVLSWNPLNPSVLGSCGDDNVVILWDLSNQNHPILFQHNGHTDTVREFSWNENIPFVIASVSFGNILQIWEMNGELYSGLNQITNIPSIQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Y0</accession>
    <name>A0A9Q0L8Y0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8Y0"/>
    <dbReference type="OMA" id="QFMYNEY"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="190" mass="21748" checksum="11383D7B74C18649" modified="2023-09-13" version="1">MSDLKIAVVGGGGVGKSALTVQFVHSKFLADYEPTIEDSFRRQVKIDEKVWMLHILDTAGQEEFSIVNDTHLRKGDGFLLIYSIIDFASFSEIPKIRSKILMIKEETSNVPIVIVGNKSDLEKQRKVHLSEAQDLAKSFQTPFFETSAKTRYNVDEIFFSIARMIRNQKFPEFSDSKNIKKKKKKRCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA98</accession>
    <name>A0A9Q0LA98_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA98"/>
    <dbReference type="OMA" id="GWTSHNI"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="216" mass="24406" checksum="76C6A09A9522896E" modified="2023-09-13" version="1">MQTNQKPQQINLENQSEDKLYTKEEVMKHCSIAFIQGWTSHNIFLSEQQNKQNKQNKKNKNKKNKNQNQNQNQNQKNSNQNQNQKSKFKSKFNALTRKSNEYKLVLIVNMGLGMRTGKIAAQCGHATLSAYKKALKLDPNGLRNWENSGQPKITLKAPNTEYLVELDSVARSLNIPSARIYDAGRTQVESGSFTCLAIGPALGELIDQITGNLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAI2</accession>
    <name>A0A9Q0LAI2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Piwi-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_11877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAI2"/>
    <dbReference type="OMA" id="CFAQQQH"/>
    <dbReference type="OrthoDB" id="445936at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="PAZ" evidence="7">
        <location>
            <begin position="211"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="8">
        <location>
            <begin position="481"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5069121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="769" mass="89769" checksum="4124787ABBFA0AB4" modified="2023-09-13" version="1">MDLKNIPEPRLGQNGYKTPMIANYFPVSIRVKEIYQYDVKFEEPLQAIRPRFSLLSQIEKDLGSFVYDGFSILYMMQKIPDYEKVVPFRRKNVKVIIKLTKVLSSDDNDLQPFEQLYNIIFGRVMNCLDFQQIRRNYYDNRNPVRNDQFHFELWHGFFHAIYKTKKGLSLNLDLIHKVVRQDTVLDQIKMVVSFMSDRRGGGYDRDRRSPSRIDYSNPAIQQRIVEEVSNSVVMTIYNNKYYSVTSVDFSKSPMFSFEDARKGTKITLKDYYANQYHKNIADPDQPLLVVERKKKDSTGRPIREEIYLIPELCSMTGLTNSMREDRKLMQSLSKHLHISPDERCSRLKEFVQTILKNEKARKIMDEWGMRIDPNVVRVEGRILDPIKVFFKNKVHDGERPSWDGLLKQATVISPQTFNRWMIVYPQSIDRDIDGFLNALIDVGQRMGIEFDPNKVDLNSVRYPEAKNYLEQLEKLTPEYSLVICVLPRQQKSKYDAIKQIITLHKPVVSQCILANNLRRSPKLMSICTKIVMQINCKAGGSLWGIELPKNKEIMFCGLDVCHDPYKRSQSVAGFVSSTNHNCTNFYSRVIMQKTKEELVNNLASFFFEGIKMYRLKNDKVAPKHIMVFRDGVGDSQMQYVIENEIPAIFEAFKKTPDSYQRPNVTFVVVQKRIKTRIFEAKNGTYKNPQPGTVVDLDITTPNRFDFLHDSSICDILQQITFKLCHLYYNWPGPVRVPAVCQYAHKLSFLVGQSIHQEVHSHLHDKLYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAL9</accession>
    <name>A0A9Q0LAL9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAL9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="152" mass="18500" checksum="AAEE04073E954236" modified="2023-09-13" version="1">MKNKKKKKIKIKINKIKKKKKRDYYQSKKKEREQNENQNEESKISQNQQQNQNQKNQQNQQQNEQQNEKQNEKELLSKMTKDERRAYYQSKLGDKAIPKNNQQNQKKNEKELLSKMTKDERRAYYQSKLGDKAIPKNQKNQNQNQNQKTKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB35</accession>
    <name>A0A9Q0LB35_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB35"/>
    <dbReference type="OrthoDB" id="18070at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="422" mass="49617" checksum="25CCB3F576E5AF07" modified="2023-09-13" version="1">MNLISADVNWIQIMKSINKKIAINEEYRMQKLLGICMKLSLYDYKEAIMRIKLGYTIGIYYLNSEHFHKADQILMEVIMIFEKIGNKITENYKSTESTRKRFASKRSIKKSNNENQQQNFYRSMILNPIISEFGANSLMVFADSLLVNSKYKYALLALENALEILKVIDKTKYSRLLNKMAVICYENNDLKNSLKYYYQILRGMRKEKKVNEVVFVCEVMTKILVLLGEFQQAKQLVQEVSTFLNFEVSKSNSFKQLNSQYVSLQLTLSEILLKGLEIEKAITLLRFLTSISLPIALKSDTFILLAKVYMKKGWFNEGIECLKEYENEEISKIENPNNFESYRNKSSINNVFDENYNKLKKERRMSRTYSTGHVRNPKLVTVQQEISKYYEMKNENKNPNPFEFNSDEFTENEPVFRPFIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBZ6</accession>
    <name>A0A9Q0LBZ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetracycline-efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_02413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBZ6"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="10"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="595" mass="69154" checksum="4997712C8F007AA5" modified="2023-09-13" version="1">MKNRFISFAIYMEVMILEIMGSLSSTAYRDYLLVKVLNSNKSKASFYEGIIEGTQSLLMIFVNSFMGVFSDRFGRKKSFLLILLFSGIYPIIFVLHPTIWTAFLSRIIYSVSYSNYQVCAACFADLKETGKFTTQIGNTIGFNQFGSVIGSVLGLIFVSVFHRNDVWILIASFLIGMFNLLFVFAIFPETIKQKGIWDWKKANPVGGLAYLKKYKVVWRLLPLIFFYIFSFFAVSTIWQYYSYSQFNWGKKEVYLSFLIIGISNSLAASFGTKFFVSKLGNKKAYHFGAFFGVIQYIALLINPISWISYIIFCISSFCIICSSSVSYYYERSVPEKEKGIVFGATEIPSDLSYLQQDMPIIFFLVLLNASTNKKHFYFPKLSFVIALFFAIVNFLASFKLIPKKFIHPFNSQIQNDEIIPINTKEISDEKSNDEKISDEKSNDESSNFLTDSENENQKLIKSNFENLNENENQNQNQNQFENQNQNQNQNQNQNQNQNQNQNQNQYQFENLNLNQNQNENLNENQNQFENQNLNQYQNLNLNQNENQNENENLNQNLNLNLNQNQNENENENQNQNENLNQNQNQNENLNQNEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC51</accession>
    <name>A0A9Q0LC51_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-actinin sarcomeric-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC51"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="894"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="720"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1024" mass="123070" checksum="11A6EC9235D910BE" modified="2023-09-13" version="1">MDKKFKQLLDLANAKKLILDDHLKREEFIEKVRQMNDEHKDKYEKLVKCQLNLFNIYDNEYKNYQENDLVEFHKLGDDTMAQKYQTEYSEYIFNETKYQGKTFGKNQFSDLTDRHDDMDKKFKQLSEWANAKKLILDDHMKREEFIANVRRMNNEHQDRHGKLVKWFETKKAYLEIKEEINSIPDASKYLDIFNSYVNEYNEYKENDLVELKKLGEKTMAQKYSTEYSEYIFNETKYQGKTFGKNQFSDLTDRHDDMDKKFQELLEWANAKKLILDDHLKREEFIADVRGMNDEHKDKYEKLVKWFETKKAYLEIKEEINSVSEARTQLNLFNIYVNEYTKYKEKILVEFKKFGEKTMAQKYQTEYSEYIFNETKYQGKTFGKNQFSDLTDRHDDMDKKFKQLLEWANAKNLILDDHLKREEFIDKVRQMNNEHKDQYEKLVKWFVDQKAYLEKREEIQWLKNIQTEYSEYIFNETKYQGKTFGKNQFSDLTDRHDDLDKKFQELLELANAKKVILDDHLKREEFIEKVRVMNNEHKNKHEKLVKWFEIKKAYLDKCEEINSVSEATTALNLFDSYVEEYKAYQEKDLVDFKKFGDNTIAQKYSNEYSEYVYDETKYQGKTFGKNKFSDITDRHDDMDKKFQELADLAKNKKAYLDDQLQLEKKKEKLRLDFANAVSEYTALVKLEIENASLREFGFTLEEVEAFRAVIDDSDKKTMENVNKMKTECEKVKKELDVYQVTDNPYTKLTLDDVEKSLASLKEALSERIKAYEIELKRQRDNDELCRKFAGLADPFSKWITEQKDGITASKESLEKQLEFINNCIKQLPEEKKKLDPLKDLQEKMDKAGIQNNRHTTLTLKDLIVQWEQYESFLNRKKKMLEEEIEHQKLRGITEEQMQEIEENFKQFDFDNSGTIDRKELMACLYSLGEERTPKEINKIMEEYGDGKDISYERFKDFMIVLFGDTDTKDEIINGFILINRGFKVAKKDLMELVMEDQDIEYIFKTAPQVEDGYDYHTWTEEVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCJ3</accession>
    <name>A0A9Q0LCJ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab5 gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCJ3"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="311"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="546" mass="64390" checksum="1261C16B1744B6C0" modified="2023-09-13" version="1">MQDSLTDKSLSPFLQFIKNESYKELGFLLIYSPTILIPSEYSLKSIKLTIPFIETHIIFVNKQKNEQFVTANGALGIISKKYHKRFFEVLKSPPKIIEKKNYQLIQNRKYREFFEINQAAFKKKPKEIIAKCYYMKKTTFQFNPKLPESTIIFVSQPLVFSKCFWGQVVYENFLTKMYQFHVQYLSQSQKISKKRILSEEEFEKYIENNKTSQISHEILHFIIGFPSKKSTQKTYTSLIEGFLQNFTEKFSSFPFLSSLSTENLPNENISNTETEAPKKSINTEELYHVSKQFIMKRLHEKLFNVNLEENSNLDSRTHLNFSRLQFLSLKNFRVQLEQNEYEKISSAQEKLSEINQKLTPNDKLDCIVETCKNLMKMTDNSFLIQNRRHFSTLLSYVILKTNPEKLYSNIRFIQNFEDPQALEISGKGYFLSLFLQCVTFLEKTAKHFSSHFDLHESNDLRDESTVSEECLHRFTLLSQHLENAKKILLSRNNELINRSIFDIPIILAQRSSLDEITMKEVPLLLKEYQSVVKLLSFLHERLEFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCN2</accession>
    <name>A0A9Q0LCN2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sorting nexin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCN2"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="100" mass="11910" checksum="DE219F79FBFE293C" modified="2023-09-13" version="1">MSEAKFDWRDEIPPKAQESAKKTEELFFLIGDTWEQIGKSYIEQSNLELDKLPPYFIEYDRIISSFQPVFKNRDHAQLNYHNSQNALIKLERQIPSVEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2024-05-29" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD54</accession>
    <name>A0A9Q0LD54_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calmin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026314">
        <property type="entry name" value="YLP_motif_con_p1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413">
        <property type="entry name" value="YLP MOTIF CONTAINING PROTEIN NUCLEAR PROTEIN ZAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413:SF0">
        <property type="entry name" value="YLP MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1521"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1909"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1782"/>
            <end position="1809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2252" mass="265620" checksum="51D7CE8A9934ED1B" modified="2023-09-13" version="1">MEWFINFLEEPISFDSEDSVLSRSLCVGLNKIEKNLCSISSNSIENYNNFIIGCKKYGVEIQNEPILANFIGNLVYENKNKKIINKTNLEHPKNDGKKLLSSLTHVFGKRKQKKEKFETPKKKIQNLRKIFSLSENNQKNININIDSNPNLNRNPNQNSNQNQNSNQNQNSNQNQNSNQSISQIKQFYSDGKSSFKVFLIENKKKEIECNLTITKKEIKCFDSFGALQFQQNILDAKIILNELNLTTFVVKIEDRNYTIKTKNEDDHFLIWKIFKMFQFYSNNLSQINGSILGKENEIDALLASFLSQQNAYFVVDVSLGKSNFENAFILFDFNHITIATFNSYPFVVSLDKMTFSLHPSLDIVYMKFLLKDFISSHDIKNEESLEIVVNCKSYFDKILFAKTLVIFKQMFFFYPPNFHKKKPQQFLISKQMLNSMTHNSFLIPNILARKFANNKQFSNEGFPIIFQSRKQISNLPWDSSLITNEDTQIQIRKISIITKRLDQFVYQKFASFKINVIFQDQINPAILYFDQSTISLQLEKDSEFILKTNYTSVKGIHLHSIIPIYFVIQTIRDNFFFCSARSIWQRDLICNLFEKSAGITSFKTPFISTSISPHSLKPSKDLENIYRICFERLNTQQTSFEIIEDEVTDVSQERVSNEMASFQVKIIDSTREVSSNGVIVLMNDEFSISNDNSEIKKKYSLYTTVHPSDNSNHSCWVALDEFNFIEVLFENISTKSRFISSFNSKRNQYCKFDLNPIICECFVSSNVLEKVEALAILYDSYLRIMTVDDINDISIPYTFANSLSNSKSENSIKIKLFGEYLIHLIFASNQKLSFFIDNFTKLTDKFIFPHETHRYQLKISSSEMEPIQAQLRLSHVQLALISELFFLVFKNEEFAFLWKTQNNKEVEMLLPEKNKLELEFNTPEDSLDLFRNLTKTEFPGNKDGNENLFNISFPTPKETSNNSGTIQIVNSKIIMNNNSNNNIMVHDITKSQLFSNNNDFKLTFPILGYENLFKFQSKTEDHNFCKIFTSISNSQPFQVEEFPFLKISSDSQNYLQLNIKIDSVYQANILNSNLDEIGSCEVSIQNEILTIKTMEQRKVLNLKTDKIKVASKLHENIIKIMSHEKAYHISFQSNEEKSNFITDIIKVNFNIEHYLPKTKIQREPKKKHKPRSHIEKEKHTRFDNLHMKEKQEIQIEEKINPKYQVTLLSPKLTEMGYCQLALQNEIFMISSKDQNSICNLEKESINLESKPNQSILRITIQGKSTIVLFKSNEEKDQFIEDIIQIKKKYHQSSKNNQENEEEKENKGINYQVTLFNSNFVELGSCQVSLQNEIFTINSKDQNLIFNLEKDDIKLGSKSDQTMVKFTIKDKSYIIEFKSIEEKNDFILKFMEIKSKLQKSLLKTEQKQEPKQEPKQEPKQEEFKYSGAFLNSNFVEMGSCQLIIQNEFFTITGMNQILKFNLEKDDIKLGSKSDQPMIKFTIKDYSYIIEFKSIEEKKHFISKFMEIKSKYHKSLLKQELKQEQKQELKQEPKQEPKQEPKEIKIEKEPKETKIEIEKEQKQEEFKYSGAFLNSNFVEMGSCQLIIQNEIFTITGMNQNLKFNLEKDDIKLGSKSDQPMVKFTIKDYSYIIEFKSIEEKNGFISKFMEIKSKYHKSLLKTELKQEQKQELKQEQKQEPKQEPKEIKIEKETKIEKESKKKFKYSGAFLNSNFAEMGSCQLIIQNEIFTITGMNQNLKFNLEKDDIKLGSKSDQKMIKFTIKDYSYIIEFKSIEEKNVQNKIRNEILNQVRNQIENELENKYKESNHWKKRFLMNYKENNYQNQLNHQENIYQFNQSIYTNKNQTDNDNIRIGKTQEKQEQIEQKTFHKSNQTQIQTHTHNKTSYLTRILANSFRNTTFNHLNIENKNQNQNENQNQNQNQNQNQNQNQNQNENQIENQNQIENKIQNKIQNQNQIENQNQNQNQIENQNQIENKIQNKIQNQNQNKNQNKIQIENQIENKNQIENKIQNQIENQIENQNQIENKIENKNQNQIENQNQIQNQIQNQIQNQIENQIQNENQNQNQIQIENQIENQIENQIENQIQNENQNQNQIENQIENQIENQIENQNENQIENQIENQNENEIENQNENQNQIENQNENKIQNQIKNQNQNQIENQNQIENQNQIENQIENQIQNQIENQNQIENQIEIQNQNQFENENEIENQNQNQIENENENQIENQNENQNQNQIENEIENKNQIQIQNQIENQNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDB2</accession>
    <name>A0A9Q0LDB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras and ef-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDB2"/>
    <dbReference type="OMA" id="SAHGVMC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="197" mass="22277" checksum="130D11B350103AB1" modified="2023-09-13" version="1">MAEDEEKTLKILIIGNSLVGKSSILLRYCDNQFTEEMGTTIGVDFRFATLKINDEEVKLQIWDTAGQERFRTITGTYYRNADGIMIVYDITKKDSFSQVKHWFQEIKTNAPENVVNLLVGNKADLENQRDVTEESGKKLAKHFKCSFFEVSAKTGNNVSEAFHLLAEQTLAANGNFSTKKKSPTVNFAKKKNKKSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDE7</accession>
    <name>A0A9Q0LDE7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDE7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="349" mass="41205" checksum="8D142F97D00BDF97" modified="2023-09-13" version="1">MKQNFKTDIRDTQRWNETEEEYIKRKGETRKVGKLKKIEEKEIMELIHISDISDVVLFPINKQNPIKALVIADLHFIPKIEGDNSIDFNSKTLDILDKVVSNEKPTHLFILGDIFQKIVQDKSFIYQQFENFCKYEIPVICLGGNHDTKILSKAKKHFLKKGSEKLKKFLQIHETLFFQLSNEFGNENKNQNQNQNQIKNQNENQNQNQIENQNQNQNQNQIENQNQNQNENQNQNQNQNQNQIENQIENQNQNQTFYDNIFLSHHGGNNYKIVYSEMVPFIRGLKLQNNKLISEKDFLLIGHVHVMFHFFNENFGSIGMFSSKWEDLISYAIIKSNSNNKLTIEIKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDI7</accession>
    <name>A0A9Q0LDI7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDI7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="477" mass="56200" checksum="B38CD19E5A282190" modified="2023-09-13" version="1">MADSEDNAVVLCFNSLQEMIGNRIFTKKENYEKKEKENIEVNLIFTKLPSEIILLICKFLSPGEIIKFGMTCKIAHFITNETYLWRIKSMEYHTYFIWKKIQIITHFNEKTIIGFQYDIQSEIKKITAKKNTPNHNKFYLQDNEEKIKNKHRKSPPIFLNGKIGKFFSSKKQRIKYIQLLKDPQSELLGRAQKLFLKLKELKEMKRVQEIIDTRKRIADSKKNLLIKYLTIFAGLVPSAFLITLIIFNFTLSYEINHKAKFAISPLVILGLGFVVILGKHIFFQSFDTTFFLLFLIAFSWVFGFISFSLKHDEIVDMRWIAIFLPIWVTLAIIFWIVYKDPYLSILTRFEQIFYFGFCVSFASSFFLLSLRLDWGLLIPYFYIFAPIILLFLITLVRITAPQTIRLRTTTSPDIVLVGIFMCLLSVVVLVFRLHNFFHNFTLAFLPFYLILLPVSFLFCFFLLHFSAVEMSEDDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDX7</accession>
    <name>A0A9Q0LDX7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDX7"/>
    <dbReference type="OMA" id="YIAHSHY"/>
    <dbReference type="OrthoDB" id="18598at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="782" mass="89113" checksum="4A8AF43AB4C1C0DC" modified="2023-09-13" version="1">MGDFREVTEQDRTTAQALVENYGVIMTLCWFQIQKTKKKKEDRLFVVSNFHFIVIPGTKNGIKKKILQTAHLYNIKKVESSGEKKLKITFDSFEVELESVEADNIYRLIESKYMKIVQGFPEEKKAKFICQPEGRIVPFQVPAMTSSDAFVNRYEAYCRYHLTNKNQEFIDYVEKELFLSEDLSKKYNFDLTNFKALDKIKADDNQINAIRDALRNDYHFTQFTIFNSDRPDFLKIFSETFTENTTIRKVTISGLETAEGFDELGNALQKNKNIAVEYMDLSVNKIPDKVMMSSLSKGIEEMSSKLTHLDLSFCQLGPKGISSLFNALAKSGGKGKLIYLNLSNNVFSKQGSQAFKKWIESTKENNPIEFLNLANTGLEMKVVTETITEFLSESKLKYLNLADNDVLAKKKDDCVVKMIQTSKTLRLLDLARTKIIGEMAGDIVDAVLGNEKLLQFTLNLTNNDLGIPGAKSITRVLMKNRDSAALQELILDDCKIRTDGLIALCGLDGFLSNKSIERLSLSRNIAKGKDVAKISEPLSQLSEMKNLRYFRMRGNDKFHLAKNIQDLLAKLQKNTNLLALDISGNRCGLDALKELTNMLSQDACNLQLVFFDNNCSTFSNLQEFVWSLKNNTKLFRFQWPKSDIEQMLSSMSKKEAKSTKKKIKELKEKANFYANRNFHSVQTPQISPDYEELEGADSSLIHKSSLKLLNDFQMIPDYVNLKEEENIQKSSLSNLDPSKSIRSAPLPPLPPVPQIESDNDEKEKQSDNDDEKEKEKDKDKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDZ0</accession>
    <name>A0A9Q0LDZ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nucleolar RNA-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_01917</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDZ0"/>
    <dbReference type="OMA" id="NPHGGKE"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="211"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="376"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="531"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="733"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="885"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="13">
        <location>
            <begin position="1046"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5070936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1175" mass="138401" checksum="FED5D9E466768EE4" modified="2023-09-13" version="1">MEEVIDMRSSDESENSNNEETEQELSSEIEIENENEIENDFENDFDLNEFINENENENENNQLIQNQNDQLNQKNLNQKLPSRKELSQIKENQEILYSNIYKIQIELLLKKIGLDYKKKTQDIKEYLFELKNKIDGIENIKFQIKKNQITINQLQKSQQNQKQFIYSFKKSNFPNLKLSNDTLRMNILKPSNTYLIGSFLTESLVKPYLNIDVGIEIPSDVFEQEDIFDYKYHDKRAIYLHLISQYLQYIDPEQFTNANMHFSFFKGNRRKPILVIKPGFINIATENNTKSEKQKKRTKRKKERLEKRKTKFVIRIIPMISQKTFDINKLSLESNNLKKNSNQNSTPFYNNSILEDMFFYHHLETIHETITNSKSISEGILLIKEWLHKRKLYSYEDGISGFLASIILVFLIYKKRVIPSMTSYQVFRLFLEFFNKSDELISQGIIIDDQNRKIQEKDKLILQSFRKHFDIVILDEFKACNLAAHFKLSSFYAIKEDARITLDLLRNGENNRSLTILNFQNIFLIPTNLNLKYDGYITISSIENFKKKAKKIKYQDCGFENYFKRKIYRILQKGYGNRISSLAVFKPNEDDYGDCNIQESMKNHFKSKFSLIIGINLNPENCFKIVDRGPEADDQIKAAKFRKLWGKLSELRRFTDGSILEAVAWEKYTEKQESIPRAIAEFLLAHHFGLEVGKHFHFIGDKFSKLIKIQKMVIRSGFQGKKKTVLSHYHQICELVISSFQKISQNMKELDELPLDIISIQPLSDIFSQTSIDVNKPIEFKLEFETSAKWPDNIQAIKHLKIAFLIEISKGLEKYHKINSKISLDYLDVFTNSGFVLRFFLSNGKENDLLEKNRPQDYKEIEKKILFEPNHRDFITQNFTKKNQIYPELTRLCKQWIHSNYLSDYFSNELIEILVGYLFSTSNIRYSQPNSLYSGFLRFLDFMINFEFQNFPIILDPNHILSAQDLEKIDKQFQSLKNKVPIYVSTSQYPIGTRYTSENPTKLIMKRMQKIAQKTLNELLSIFETQEITNKELFNQIQKIFQVQITDFDLIIKLKNSRLIRKKLEKNGIDFYSGFSPKEKFLQELNNKLGFAILFFHNQMELDSEIGIVFKPSSFLPKEFKLSDLTSINCAIPTKIQEDNLITIPNIFEIISSIWIIGEGIIESIESNFENKILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE41</accession>
    <name>A0A9Q0LE41_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE41"/>
    <dbReference type="OMA" id="CDTFQEQ"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054472">
        <property type="entry name" value="WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22977">
        <property type="entry name" value="WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="603"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="856"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1071" mass="123383" checksum="81413E9E914938FD" modified="2023-09-13" version="1">MEFIEEFEKKSTFAKYLLNPFFRQVLQFDPKKPFNSDAEYFELMEARLWFCFLEHELQTNNADSLVLPIGKTLHLNFEQVIEVLSLIKSLDQKVIEIRESKLSVMKLKPRVVRWSQKVGLSEKEALGFTYLVLNQTGNHVRGLEDFQINIPVNFVTYTGMNSHELMGFFRETRKHIKESIFEYFDPHYFLQNTLYIAEEVLVALLNGKMSEEQILKIDKTTLQEVIDEEKTEDKIEVKEKEKEKEKDKTEVKEKIEETDLFEFIKKEMTADKITNKTDENLKDFAERFNKQVKEEKDFGYGDDQTQLTEEVEKDIEKITGQIENVEIVEKIGNVKKVELTEITENGDKMENTEMVDKEENSADLKPYKTDLEYLEDYFEKFTVLIRISNERQNEMQSRIYGGYAQSEVILRQLIAKERVLGKKCERRLELTKKEGEWLPRIERLSEARRLNEFEKEVVLFLVGSNISQSMQNAGAVRDLSVARLIRFFCRTLHEEMEKRKFFYKTGTLIRDGIVRVLGAGFHNNLDDLYLTVDRRMLDFVMGIDTEMSEMVEGSHLYSSQVELDNVILGTEQKQTIVRTVLEYDNFVKCRNKLGLEDVITFSGGIVMLFYGESGTGKTMMANALGNALKKKIMLVNFPTLGQSEAGENIKYIFREAKIYQALLFFDECEALFESREHGKYDVNLLLTEIERFDGIIILATNRAFDLDEGMHRRITIAAEFTKPDALLREKIWRTHLPPSLSLDKDVNIKALASKYELTGGFIKNAVLSALSLALAESESHTNVTLTHKHLEQGAQFQLRSRLRMVDFHRRVVPQRGMDAVVLPKETQDILFEIINAEKARQVLHNWGFDSQCGFQRGTTVLFTGLPGTGKTLAAEAIGFETGKPLKIVNAAEVLSKFVGDTSKNIDSLFHQAAVHDSLLVFDEAEGLFGKRHLDQTNSVDRYANVDVGLLLYHMEQYNGIVILCTNKIDLIDPAFFRRMKYVVDFSLPSPSLREKLWKILIPNAAPCDSDIQFSLLARDFAFAGGNIKNAIFRAASKVALRDEGDRSIHMDDLIKAARDEQRKMEKSKLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEC9</accession>
    <name>A0A9Q0LEC9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonucleic acid binding protein s1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEC9"/>
    <dbReference type="OMA" id="HRPKVNE"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="309" mass="35750" checksum="B3AF95D78A1033B9" modified="2023-09-13" version="1">MSSSRTLWVGNLSYRTRARDLERDFSKYGTVLRVDIPYWPGTSRPKGFAFLEFEHNDDAEYAKKKMHKKIIDGREVVCEWAGSPPKKRSVARKGYLGSRSRSRTPRRYSRSPRRYRREKSPPRTYTRHKRRYSRSRSYSRSITSSVSRSRSYSRSYSRSRSKSKSNSRSYSRSKSRSNSRSKSRSNSRSKSRSYSKSNSRSKSRSYSKSNSRSYSRSNSKSNLKPKSKSKSKSKSISKSNSKSKSKSKSKSKSISKSISKSISKSISKSKSKSNSRSKSKSNSRSKSKSKSISHSHEIKRRRKKTESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF16</accession>
    <name>A0A9Q0LF16_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF16"/>
    <dbReference type="OMA" id="MSYATNR"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="195" mass="22062" checksum="EA3DCD0D1C291B8E" modified="2023-09-13" version="1">MIQSIKSVLVGDGSVGKTCLLLSYTTNSFPVDYIPTVFDNYSANTMYKNKVINLCLWDTAGQEDYDRLRPLSYPQTDVFVVCFSLISRSSFENVKTKWIPEIRHHCPNSPIVLVGTKLDLRSDSNIISKLEAKNSSPVSYQEGYDLAQQIHAYKYVECSALTQKNLFNVFDETIAAVLEPKTSNDKKKRKKCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF77</accession>
    <name>A0A9Q0LF77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF77"/>
    <dbReference type="OrthoDB" id="16573at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057228">
        <property type="entry name" value="DUF7906"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31515:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31515">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25483">
        <property type="entry name" value="DUF7906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040307494" evidence="3">
        <location>
            <begin position="21"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7906" evidence="4">
        <location>
            <begin position="414"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="924" mass="108072" checksum="6B421382490181EC" modified="2023-09-13" version="1">MNSFFFFFLFLIFFIHLSLNQENNSNSKLNSNSNSKLTSKSKLNSNSNSNLNLNSKLTSNSNSKLTSNSNLNSNSNLNSTLKLNSNSTSKSKLNSKLNSNSNSKLTSNSNSKLTSNSNSNSNSTSKLNSNSNSNSNSTSTLNSNLNLNSNLKLFSDEEMILAKWIKYENLSNAFEIYHFPTTKLQFHLNILFVGFEGENTEYLGFSTIYTNTWLYSQIKLITHKIITENFQTKENQDLQYQPIMHYYYLHPKVEIALKNAILILKRQDKIRNDPKNLNQSDSFPVYQVDVDKFSEILLDLLNELRLNNNSYNLFIFNFKNPFKYEQTYGYRKGFSDSEIEWIRNLDLNSLQLPNCQIESESDDLHFKQRNSPIFSMFRDTEIWSDKQIEEQKKTFLNPPQKFECRSKNSFYKGDHSGESIALQILSGFGNLEEKKYLKQIREDFSIHEDCLVDTWISSERFAFIDLSAGPFEYGFWKGGKGTRTHRTLPIYKNLKPEEQDQFLLENDYEKYFLAKISSIIERFINAIIMPHSISMDEKMGKFYPRVIFHFFIISEYSENKGNKLRGFDTQKFREELMRLKNPKQEFSIIFHEISLTVDAKLAFAFSQSLKTSNVTVSYNQEGEVQEERLYIDSGHLVNFLKDNFEFQKEIQEKNERIFDKKNHKDISVFFFSLDRKTPVYIDKYYLSRAVSDIVLIVQSNFSEIKGDYICNGKRNYINMNNPLKPALLSFASLFAGLPDEQKENIDQDYLFSVGNNPFSTTSYHPNFKFSQIHIDMIYRHYITYSLLKSLNILEESISILEKIKTTENLFKIKNLIPSYEIVQIYFLFNFHKNNLESYVSNLNFVQALLISKELVLLSKKFQNVIHQFQFVLEQNNCLNNHQIDFHFDDYSVFKINLIISFSLFIVAVFVFVNSKRKRPKVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFC3</accession>
    <name>A0A9Q0LFC3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFC3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="514" mass="58513" checksum="869C8376F49A1D8E" modified="2023-09-13" version="1">MESIEKNLFKFLELNQNAIPQFLESNLNQFLDSFSFDESNNFIGDKSVKEPKAIVIIHSAIDNFDESEINSKTSKNEEKQTIQGVNLKNQASLAIMMEIVKAFNPKNIQVVYLGISQMKDPKKANELIFEILKKADFKEKYCISIHGYSETVNVDQGPVTITISYENTHKRIYNMIKTISEKEYDPNPFQFISHEQYNRFGLVNLKIDDDCEVLPLCFPISQMQEKESLISLNDLSKVYVITMRMLELLDRSRYHYTSFYEETPNVVPDAEPSLNTDLLLDLMRIASPTGYEKRLRDYICKNILTANDILFETDSFGNIFSLNLPNRPLLCAHIDTVQQMKDVIYIDTVKRTGNIISGQGIIGADDKCGVFVILDLLLNHKMNFNWLLTCGEEKHLLGAKAFIESSHAYKLFELPYALILDGGGSRRVIRCYESGFGPYSLDLFLSNIGSSFGYSSYFSTGSNDARVLSTFINSATISVAACNIHREEEFVDIFGLIDAHKFVKKCLESEFSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFG5</accession>
    <name>A0A9Q0LFG5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ada2a-containing complex component 3 isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFG5"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="576"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5071731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="688" mass="81537" checksum="1AD4F3B3F55E71A5" modified="2023-09-13" version="1">MENQELNDLLINACQNEYKHKNKNTFETIKYLISNGADVNFGNFYNQTPLHLICEYQKENTLKIMKYLIEKGADINIKRQYFYNQTPLHLICQYQKENTLEIIKYLIKKGADINEKTQKEEIPLHLVCQHQQKNTLEIIKYLISKGADINAKNKGTQTLLHYVCQYQKNEKALETIKYLIKKGLDVNASSKYKQTPLHFACQYQKNENSFEIIKYLIEKGADINVKNKSNKTPLHYVCRDQKQNTLEIIKYLIEKGVDINAITNEKETPLHYACKYQKHEKALEVIEYLIKNGADINAKNRYDETPLHFVCEYKKQKALDFIKLLIENGADINSKTLFNQVPLHLIFQIRNKKFLVEITKYFISKGSDINIKSNSNKLPLNYAIKDKNQKLIKLLIMNESDIPDSDTNEITKEIIDLFLKTYSINQDLNNLLNSNDNLSDFEIETNDLFKFKVHKQILLLRFDYNQSNLQKFINNCLQKPKEIVEIAINFIYTGFPNFDNFIQKLQILKNYIIKIDELKTKEEEEELKIKETKQNEINEEFFKEIGFDLNWIKSKSKRKGIIKDLSKLYEENDSKKDFTIICSEEKEIKVHKLILFLRSELFKGMFQLNIQDKSNQVHDYSRKSFETINQFIYFLYHDKIEENKFNSKIIEEFEDIKDYFQLNQNSIIDLFLNDLISSNKFKNIKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFJ1</accession>
    <name>A0A9Q0LFJ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sorting nexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFJ1"/>
    <dbReference type="OrthoDB" id="10680125at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="128"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="9">
        <location>
            <begin position="238"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="457" mass="53251" checksum="B15DE2832DD2744E" modified="2023-09-13" version="1">MKIKLKMKMKIEIENENQIENENQNENNYEFQDENQIENQNNYEFFDESLPPPPKIIAEDFTQNFEPILEQDLPPIPIEFQTQAKYFLDENFVWKLDEKFVPLKFEVSLLPSNSKSGGKLDKMKFLVVSSSQEYTVERTFFQFRTFRDQLSEQFQSCAIPSLVNIKKNDSPDKILAIFLNRIASHPILGTSDLFKDFIGIEVEIKESNKFDFENEFESAVSIANTTYKISIEKFGLFLQNLENQFKELRSGFNSQTTKYKELSVIFSDLASKVTGFSKIGLDWRTKENLDEDTINTIAAISNSLVGLSSCLYKLYKIYENDLRIPNDLICDFFNEYFGIFSAFDDVWKQKDRIKAQKELVTQTYQKLQTSTSKNFQKISIEGEKLEKTTKLDAKFELAILAEMENFRYSLSSDFKSNLENYVQSQIDISEQMTELWKDMIPLIDSIDVKKGSKENSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFP0</accession>
    <name>A0A9Q0LFP0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFP0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="416" mass="47339" checksum="9F4F9107C52644CA" modified="2023-09-13" version="1">MANLWGKRPEHSTGNSSPSQNKPQNGTTGLTLFSNKNLNTPTQNTKPGLFSSNFKNLPQQSPIRQTTSFFAKQGGPVFGQSLANRTNSQHVNEQTMSQSSQMEVSKTQDLFAKKQTHNLFANFSLSQNNPPNSSFFAKRDQNQNQNQNQNQPKTSIFSTQNQNQPKTSIFSTQNQNQPKTSFFANSQKNQNQNQNQNQNPNPNPNQQTPLKLPFLSTQNQNQNPNPNQQTPPKTSFFANPQKNQNQPKTSFFANSQKNQNQNQNQTQQTPPKTSFFANPQKNQNENPNQNQSPVKRTSIFSTQNQNQNQNQNQNQNPNQNPNQQIKIKIKTKVLPVKRTSIFSTQNQNQNQNQNQNQNQNQIQTQIQIQNQNQNQIQNQNFEGLSEQDIKAYKADKFQPGQIPLFPPPPSLIQQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFU1</accession>
    <name>A0A9Q0LFU1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFU1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="191" mass="22369" checksum="2FF7B948AFC85D1C" modified="2023-09-13" version="1">MDHDQVKSLGRKGRRNKRKKRKKTGHRLHVSPCSKRLGNSIQKGIGWGFANLAKSRLDKKLAKDLCRKFDSNFSISAKELEQQIQKEHSIDNSSHFERLMKNNLNHFANKDEKIEKNSYNDFLFSSQIANDLIKEFGFEMFDPLGEETRNNMINGNENENENEILRNELTDIIIELLEEYEIVDNEKENID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGW9</accession>
    <name>A0A9Q0LGW9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_01637</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGW9"/>
    <dbReference type="OMA" id="FIVCLNF"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000040">
        <property type="entry name" value="Putative ribosomal RNA methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="11">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="321" mass="36312" checksum="B2232A0B00BADFE4" modified="2023-09-13" version="1">MGRKTKDRRDIFYRKAKLEGFRARSAFKLMQLDEEFKLLSNVERVVDLCAAPGSWSQVIANKVYHSRNEEERKNVKIIAVDIQPMAPLEGVKQIQGDITKQSTADQIIDFFEGKKADLVVSDGAPDVTGLHDMDEYIQSQLVLSALNIATNILKEGGNFVAKIFRGKDVSLLYSQLRIFFQHVSVSKPKSSRNASIESFVVCHSFKIPENYTPTMTQPILLQNYDQDHQLTGLNRFIAPFLACGNLSPFDSDANYSLNANLGEKTPNQSIQSNQINSNIPQEKDEKSKEKPDELYKFKPPVQNPISPPYSKAIQKRTKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGZ4</accession>
    <name>A0A9Q0LGZ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGZ4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040455000" evidence="2">
        <location>
            <begin position="21"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="692" mass="78749" checksum="009D2ADD5873D6A6" modified="2023-09-13" version="1">MNSFVLFLISISCFFLMVKSEFNLKSSLNLPLGIDYAQQTYLDEDEGYIYFVDKRRNNDYFLWKYDMYTLDYLDYSKIIDNFETGAIDTVNKLLYVVPSSGSQVAKIDLNTMQVVDSITLSVPSYSNSKKVEIDTLNQKAYVGYRDPICIVKVDLASFTEESNLTLSNDKVTGSVIDVDNGILYAATDSTFGGNAIIYKIALSTFTQVDSLLVNLSGVSYLRYGVIDNSTQMMYFGTNQYPMNIVKINLTDLTSVGSINPSLQPSCLGTGIDVPNGFAYFLSEYYLSKLDLTTFTIADSYNLQNDYFTSMAIDSSAQNAYIATSEHEIYQVNLPALTNGSKSNDMIYIFAQLILVDETNQIAYIYFDSYGGVIVKINLQSFSFVDYLIIGLSLDIYDGEIDNTNGFIYLFPDNGNLVIMKIRLSDFSINETVQVASSGSVSYTYFDKQNQLLYVVFHNSSDNTRNLMEISCPDLQIIDSLDFGNVDVSRAFFDISREYSYIWYYNFSAVGSRYFVYKVELSNLSIIDQIDLTGYDIDECILDKTDQLLYILYYNIDYYFLRSIDLVNMQVMNNTLNTTYNYYFIFLIEPNDALLFLDMGYYNESSDEYEGVVLLQIEASSNELISNTSFDHDLFDYYEYGSDPSTNYGYLLDFSSNPVTFYQISFTSPPSSSQQILFSFLIFGIMILILGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH72</accession>
    <name>A0A9Q0LH72_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH72"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="266"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="68988" checksum="D6B5069DF9591753" modified="2023-09-13" version="1">MNDCLFFGLNYAPKLLKNELFEIRKPIKFKFENENENENEKQIKQIPTGDFGTIFLFKNGKAIEYLNENDSNQNPEKIQIEENIQKVSVGWGNEAILTIEGNVFAKGRDINPKNPKEFINISSLIEDTNDRIIEDIVSGFSSIYLLTSNQNAYGIGLNVNGQLGYDFETLKKTEKPILMMKNVSRIFSGNSSTHVFLLNSNQELFGCGNNQYGQLGLGETRRKETYIQKLTKIQNIPKGKIINIQCGIFHSIMLIENENENENPKRKLYSCGAYTLNGLGKYENTYEFTEIKSPLFENDDNILEFSCGYKHNLILTSNSKLIAFGSNSYGQLGTGDTKNQSIPIQIELPKLRFNENISNYHVSCGYQNSFLYYYSPSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNQIEKLQQIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH76</accession>
    <name>A0A9Q0LH76_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH76"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="151" mass="16984" checksum="D91DE6B4C3C1E162" modified="2023-09-13" version="1">MGRMFGRGKGMSGSAIPYKRTAPAWLKITPEEVVALICQMAKKGMTPSQIGSRLRDVHGVGQVKAVTSSKILRILKGNGLAPKIPEDLYHLIKKAVSIRKHLEKNRKDKDSKFRLILVESKIHRLSRYYKTNKQLPPTWKYESSTASALVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHI7</accession>
    <name>A0A9Q0LHI7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nodal modulator 1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09242</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHI7"/>
    <dbReference type="OMA" id="NQYTIHA"/>
    <dbReference type="OrthoDB" id="10263633at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055074">
        <property type="entry name" value="NOMO1-3_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055073">
        <property type="entry name" value="NOMO1-like_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056190">
        <property type="entry name" value="NOMO_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056319">
        <property type="entry name" value="NOMO_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056187">
        <property type="entry name" value="NOMO_8th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051417">
        <property type="entry name" value="SDr/BOS_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303:SF14">
        <property type="entry name" value="BOS COMPLEX SUBUNIT NOMO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303">
        <property type="entry name" value="CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23141">
        <property type="entry name" value="Ig_NOMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22904">
        <property type="entry name" value="NOMO1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22902">
        <property type="entry name" value="NOMO1-like_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23194">
        <property type="entry name" value="NOMO_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23660">
        <property type="entry name" value="NOMO_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49478">
        <property type="entry name" value="Cna protein B-type domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040413005" evidence="5">
        <location>
            <begin position="20"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1077"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="SD-repeat containing protein B" evidence="6">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO fifth transthyretin-like" evidence="10">
        <location>
            <begin position="358"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO second beta-sandwich" evidence="8">
        <location>
            <begin position="465"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO seventh transthyretin-like" evidence="9">
        <location>
            <begin position="551"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO eighth prealbumin-like" evidence="11">
        <location>
            <begin position="619"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like ninth beta-sandwich" evidence="7">
        <location>
            <begin position="721"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1154" mass="132622" checksum="C5149A74F33959CA" modified="2023-09-13" version="1">MKIIQILFLSFFLIFLINSQDSIKGCGGFIKISNELKNLIKTIDLTEISIELYNTDTNFLKEKQNCAPNVPNEFKVESTCDNCEKGVKGINVNLIQNERIIRTSKTNEKGIYTFKNLLPDKYSFEIDKSTFPNSWIFDIDMIKDYQIDFINHNVNKPLTIKRFSIEGKVLDSEQNLENNKIANAKFILFTTKEMIEKNGFKIENEIKTIKEEEIEYFPILTTESDLNGLFTFSEIPCGDYVIIPVSIPFQLEPNFKKISVVNNVFDAGNFKVLGFTAVGYVKNKGGSPISNVLITINDKETAITNEEGQFKFGNLQKGNFQIKAQKNHFYFDNELTKNIILSPSNYQIQDIIAVGYDLCGTIKLQNNQELKRKINLQMIDSHERKFTQITDNKGEYCFKVISGEEYIIQPILTQKEIENGFSLNSITVFPIQVQNEPIFNIDFIQTILSISGKINCILSNCFDLKIKVILKENSKQISQETFINKDGSFVIDNVIPGNYKIRVDEETFCWENEEYPVQIETENIANIVFQQKGFLLKAQSSNSFIAECEILSFTQDSETIAKIPIQFNQGLNLICLEKWGLYRIKPDDCFLFEKEEYFYNYQKSRNEVIDFKLTHIKVEGILEIEEKEENLNEIQIDIKTIKTKTSDEGEITDTKTQTIFAQAQSSSKPSSYQFTHYAKIDSKTIYIPKSKSLLFYPKNQEIENLNGQECPIKLRIFEGKKGKFITGKITPALEDVRIIIKNEAEKEEYETKTDSKGKYKYGPVEDPGKYQISAIKAGYVFTEEAEKGMFRFRKLGIVQAIGSNNIVGVDGTFLYQNLEPGEYYLSVMLKEYDFTPSSGLIKVEEGKDVDFSIEAFKVAFSLFGSITTLNNKPITGLTIRAESQNLKEIHQEETQSNSNGNYRIRGLKPNVNYLISVMKKSSSQKIIPNQISVHIDQSDVSNLNFIGFDNKNNLSQIIGIVNSSYINNITIELVPKLDSIKKEMEKKNFPMKVHPIPLSLNQSFFYFPNVLYGNYSVILNTDLSRNEYTFDKNPQIEIIINENENEKLFGNLSLNDLIQFDFYPKNLDNSQFNSSSYSPFISLFFLLLLAISVIAGLNYKITLEFYKNYQQSKSFKISFQKIWKKNQTKIDDSNDFLNHKHFGRTKINKGKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHS4</accession>
    <name>A0A9Q0LHS4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmc family peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHS4"/>
    <dbReference type="OrthoDB" id="3906254at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052924">
        <property type="entry name" value="OsmC/Ohr_hydroprdx_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35368:SF1">
        <property type="entry name" value="HYDROPEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040340519" evidence="1">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="120" mass="13551" checksum="77831B681FCDBB20" modified="2023-09-13" version="1">MFPTGPSPIYLLLSSLAGCEVILIRLVAKQKNVQIGEVKIQVNGELDPKAFENLEIFSGFQTIEVQLKLECEADDKIIQEIVDLAEKTCPITNMFGTHPKIKFTSKWERLSKSNQDEKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHZ6</accession>
    <name>A0A9Q0LHZ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Limr family protein -related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHZ6"/>
    <dbReference type="OMA" id="KSAMCWV"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31652">
        <property type="entry name" value="LIMR FAMILY PROTEIN DDB_G0283707-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31652:SF0">
        <property type="entry name" value="LIMR FAMILY PROTEIN DDB_G0283707-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="472" mass="54260" checksum="927D855D617338F7" modified="2023-09-13" version="1">MINIILLITMIVLFVLVVIGSLYFLVYFQHEEDKNTAWFPKIVVILGLSLSCFNVLLLPMDVINRNTQGGLNIFIALEIFLMATAGFVLVIIPFSIFYYENVDDGRHPIRRAIIWTFITFFIFALIIILLYLFVGKAEIEVTLLQGGTIPETDPVQTTPCTLNCSRKYGFWDVKVSVVVYIIAILSFAGWLLFMLFGGIGIIAIPLDLILGWVHRPRRIKLEQYARYKTDINRRASDLLLDARKIDESRRIGKGSKMKQRRKYNEFRKAVFFLEEDYKNLNLAYKEFGGSPVKHFLKLLLGIVSLVVSIIWILHIILYMLPKKPISLFMNNYLNSLDDAFSLFGAITYGIFSFYLLWAVVKGNVKFGFRIFFFSVHPMRINGTIMSSLLFNTALILLSSITVSQFCAMAFADYARLTSFDMLYGVQVTNLQGFRVVWKVFTDILMGIIGLTLIILIIKPRDRSKNKILRFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIE8</accession>
    <name>A0A9Q0LIE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein vps13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1378"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2518" mass="295635" checksum="8B87E2B51BB3EDD0" modified="2023-09-13" version="1">MKFKFQKQNPLTLDMKIQAPIIQVPEFFHKPGNSLILNFGQLYLRNNSKDNSLDSTNSFESKPTKSSSQIFLNLKNAHALIFENQEQKINFEEKQNPSNYILNKFSIDLIINIPEDEETQTKLFGKIPVLDLHLSTLQYPIFIHLIGHISKSIQSIIQSKTTKIRQITHSNKINFQKKLNIDKKKLDEIGSYIEILSLEFLLQIAKLTIKDSEENQIANIQFNQSSFHFTKRPYDSQYTLLIESIFAHECSSEKQKEEPFLFTKLNDKRNQKKNIQKSVIKLSGAHHNPKSPFYKGKKSQIRIFFSELGGIIQPNLIASFINFFKLGVNSENDNIQKIEKNNNNNLKATNKPQEKKLKKKIHILKRESEKNPEYSLMEVLLKLQIRVEKTELTLVNEKKNLSRLSMNHTVFQLINYENLDKMFHIQTKNAEIFELINGNSQLIFLLENEPSQFTIQKKNQIPLKLFLNINNSLFIFSHQFVSEILRLIKEIAIFKQIIHDTIKKSKQKIEDFVKEKKVINLNFTFNNPRILIPQSDSGNEVIALSLDRLRLFNNIKRVSISEKQKAGFSYFGEEDSILMDEISIFSESLKIGTECLQKGVLNLFSDKEGTLLHPVTTKIIVNRVINHEIPCSPLVEISCKVSDIVVTSNQKQIGFFKTTLVNLSNLITILKENLKNEENLKNEENLKNNKNLKNNKNNENIENNKNIENIQNNENIKDIENIENNENIKNNENNENNENIENIKNNENIKNNENIKNNENIKNIENIENNENIKNNENIKNNENNENIENIKNNENIKDIENNQNNENIENIKNIKNIENIKNNQNIKNNQNNENNENNENIKNNENNENNENIQNNQNNENNENIENNKNNENIENIQNNKNIENIKNNENIENNENNENNQNVKNPTYFPSRLLLVFFDIEIKRIEIQLLNTHKEKKRSGNKFLLGIEGEEAKIIFSLNKTNEKKIEIITKDISFVDARTTSSTSNMHKIFSPSSLNSNHFIIHYLIDEEKNQELQIIIQSSKILLIWDFFFEIYKFIIPDIFQPQQTIGYLPELKIMVQVMGVEFVLLGKRKKEKDLLDLVTAKIDTLFMIYNDLRIKKIIDMNISRITISLKKKNLLIENLSEEDYLVDLNDIQLKKDDGFLLIDFDALGIPKIEKKDSQLQQRIENKNKQINKFTDSRSDIAKFKNNFNITSFAEEKLILKFNQVNLTLKDDWEKTIRPILNLDISKFVLNASGLISNILNQKKNFLEDYDQIPKEKDIDINIDIENKQNRKITFNQLLTKSLFEPIQISLDYILLMNYFNYHKVHWEPFIEKWNFEMKGYEYFLQTETIFNFEFNLLDRLNINITEAFFNSITFTADELISIRRSRARSKPNPKSNILSKSDSKLQTNSKLKTDSKSKRKARAKYYHFNPYWIENQTGKTLYFSLYPDFKNPFVILSRNRQPISEKYENKLSKDERNLKYKKEGNAIPSVAYISFQNDGGSKQKISLNNAGFYDLLLNKNEKEKEKEKGFFYQVFNEKGEINILKLRSNVMISNKASLEFSVGTRNKSGLCVVIGTVKNNEDLPIPQELIDEQNDFSLSVVSKRKSEELWFSFAHIKTQNVPLIFSFPKSKKTFSVRFIIEEVKKGNRLKESCYTFTIIPLAFIHNLLPFTLKATFSSSKEILPVSSYEKKEIQIFNSLQEKMMLSLFYKSRKKYTTKSEILLDLSPKTQKSFVQKLQIIDKWENTTELNMEISFTSNLICEIVIFTSNLLINDTGKDIFFTVDGKVLPGQNQVKEIERARIEQDVRQNEMIPIICEQKFFTIQMMEDDPRKKRKAMFLPSIKISTANPIAKRSTLVPFEGKTFYEFGFSVHRRKQELHRTQLFVFTPRIIIYNHLKTSIRVSQFLEHEQQKCILNIPSREWKPYNYWSSNKRFRALSLILDDENRDGSWFTYSWSQGFFATQIGTHIVSIKEYKVYKENQKENDISRKKRIKTEPISDREVHVSVDIKKKESTFYLILKMIHEFDFPYIITNNTSQMLRISQRNCKQERFIHPFTFIYYTWENPLEAKQINVYLMQTSLSFRFNLKKNMKTEPFQIMNSSTKYYFEVVRSHHTTELKLDTITKENQEMCNLDDQILQSELCHSAVLDFLPGLGISIVSNKREEILFGLFEGITGTINVSRSKILFHWEIHDFQVDNQLYSSNFPVFISEEKQNNHHFLSFDITKSRLEESIHLFLNFDLKIQPIYIMADEVLLTSLFLFYKEIVSQLTGFMGYFERKFISQKNFESHKAKTKKIIDDFRSYSRLRFCFKNFSIDPIYAIISTRIQELRYLSILTNGIGNIDAKWVFGSFSFRDRYLDEDSFLDEIKIHYLNYFNEYLISFLNRELVTKLNFSNYSFAFFGDDSPITQKVKKRLPRNFGQNQVVIPYDPDLALGQFLLYSQLKGGQFEKENCILFIKSGKKALVFSENILLYVSDFEDQKNIKSFFIPLKKASLNFVENDLFAIVYEESKIQVQIQDSKTMDKILDLISKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIT6</accession>
    <name>A0A9Q0LIT6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="MMDNLFL"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="5">
        <location>
            <begin position="556"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1392"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1682" mass="196683" checksum="35CCEC3643C0069A" modified="2023-09-13" version="1">MEKWLIEPFEKIESFCRNAKIEKQIRESCLEAKKLLKEHLQNSNSSKELLKNSSNILFKPTHLSLTSKLSKFIIPSLEVINKLIAYGIFDWKMKAINQPENRLIEQIIEDIIYCSTFFDDTIHFYVTKTLFEIGMNKSAEIYGSNLLKIIRTLFRLYMETKNITNQQTTEFLLSQLVIHILSKVESKEVQNEINQEKEKEKEKEKERERETNIFEKPIEDVKQFSSFFVNSIINKVLEDKEQKFIKEKEIIIQDTKSEFTHLNRYQADVQGLLFSICQESLKETPNFKGKQLSLDLIYQIIEKSGDILSNLEVFKNALKENVCVSIMKNGVSPVVGIIRKSHLIFLSLFKKFRFDLKNEIGIILDNVFLKILESPLSSAKQKIEILSTILQLFREPQNILDIFINYDCDEKEINSNIFERLVNVISKISQQKSIEGSENYTALVEYTKIGKIALKVLVIMTSSIFKWCFNFNYEENQLETENPNQNQNQNPNQNQNQNQNQNQNQNQIENQNISYTTTEEKSEENENSKSSNSQLLMSRENSFSNSQKIQIQKPEIFEKRKNMKTQFYEGVKLFNIDYKKGIKYLLSTKQLKKTTENFLQFFQTKELSKKQIGEFYGKPDEFNVSVLDAFTQGLNFQNQGFYSSLRKFLSHFRLPGESQQIERIMDKFAIKFHQDNPNIFASPDSVFILSYSVIMLHTDAHNPRIKDKMTKEEFVKNNRKINAGQDLPREFLEDLYTEVLSSEMRLEGDNETEKMDNESVIEKSKEVLRENKNWLNDSLFYSAIYLGHAKLMFQVSWFSLLAAFSSIISETDDFDIILSCFTGLRICVRISGLLDLDIEREAFVSSLTNFTSLSNLDQMKPLNIEAIKILLSLANTDGNYLKNSWGNVLKCISQLNHLHLISETKFAKNSLSENSLLIDTTPKNKSQINQDTNHLANTQDRLLLQLSNSQHISSTIPQDEIERVFINSVNLKVDVMVDFIRNLCLVSEKELTNFKIPRTFSHEKIIEVIIYNLTRIKTLWTGIWKDLSNHFKFICCFQDKSVSLLGINNLRLLTNQILSKHALKQLFFQRDMIDLFYYIIKHQKDIEIQQYILQSIYQIILEKSLMIKAGWKSIFEILSYISKQGNKDLFLTSFNIFQSALDCHAEIDEESFPFSINLLALFLDKHPDLGISPKALYCVKKISSQLSKRHFISLNSKFEKAQDENSQLENEHEQKKKKFTSEFVYRFWFPIFGLLSQLISNPSTSMQNRQQAEIMFFHFLHTNGDKFNSETWGIIFKSVILPMFDILRVVQQSQVFNTLSNEQQEWISTTCISLIQECFKLLVGLFPKISFLLKNFFEIIQMAIIPEFQGLISVSLTYFNEFIKRRGSELSEEMMLIIIQQLSRLFEETLPIELLEQNLNQNQNQNLIENENENENLNQIIQKIKIHNFDVINLNLQFENLKEQNGNHFENLSKHFVTFSVKDLSHEIIQETTQKVLLSQHFNLQNGKIVETSKEITEKYTIIRNKCIAQLNLIQIAHTIVLVAADKLQKNHYQLLLENLQNSNIFANSFNHNLILRFELFKQSFTQHQLPNLFKQEATIIKIFVNKVLIWKLKINRNQGSSLLTKEEIRLIESSYKNHIETYEVVIGFILVKILNLPEDLFQSWINSIYPLLIQLSRSSNINIQEMTMEILLRSWKSKNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ41</accession>
    <name>A0A9Q0LJ41_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ41"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="68982" checksum="1DCB8185223F072A" modified="2023-09-13" version="1">MNEIIFFGSNEYPKLIKNEPNKITKPIQFKFENENENENENEKQIKKISTSYFSTIFLFENGKAIEYLKENDSNQNPSKIQIKENIQKVTVGYQNEAILTIEGNVFAKGKDINPKKFINISSLIEDTNDRIIQDIVSGSVSLYLLTSNQNAYGIGSNYSSQLGFDSETFPKTRKPILMMKNVSKIFSGINKKSVFLLNSNQELFGCGDNELDQLGLGESRKQAYIQKLTKIQNIPKGKIIDIQSGATFSIMLIENENENQNPKRKLYSCGNHLYNGLGKYENTYEFTEIKSSLFEENDYILDFSVGYSHTLILTSNSKLIGFGYNEYGQLGTGDTNNQLIPIQIELPKLRFNENISNYHVLCGYNNSFLYYSPSSFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDELEIGIDYFQLNQTNPNLFDLLIKKFNIQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJD7</accession>
    <name>A0A9Q0LJD7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJD7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="183" mass="21246" checksum="557425E23EF21871" modified="2023-09-13" version="1">MSVYKTPRSLIRSLSNILTPSNNNINNQNQNIQNIQNIQNNKLNSLNKRNNNKNFSTNFTPSPIQTPKALIQKIIQAKAIKTSKHPLNPNFRQISNKKIEIKNENENENENENNLIQNVENIDFNLNTSDFSSDGEDNFNLESDSNDIQELEIINSPKKQYQLSFTNQENLKKYKQKEKLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJZ4</accession>
    <name>A0A9Q0LJZ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJZ4"/>
    <dbReference type="OrthoDB" id="10687830at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="355"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="535" mass="64054" checksum="26D0A8FB0F603C7F" modified="2023-09-13" version="1">MDNNDNNQIQNANQNQNENEMKNLEKKVTKNLIKNYSNLLNGNSFTDFSIFVENKSNPFEIKVHKSILSSRSPFFNKFLREEKYPYSISLNQFNKKEIESILSYIYYGNISFENQENLIELLEISIYFKLNLLKEIIEKKISNSINYSNFFQFLFQNRNLKLNEIEIKCFELINQNFSQIQNNENLFNLTKEEINKFIQFKQEKKEIFQFDFFQFLNNWIEKRNQRLKGKKEKEKEKEKGIEKKRLFHSFFSLFNQDSISKQDFDKFKQFDIFPNSFLIDIQNKVIQDKDKEIENKEKENQQMKIEIEGKWKKEVEEKNKENQQMQIEIEDKWKKEVEKMKQQMEFQKIFPETKIITEEEYAKKLKEWINDNDFFSKMKKGFSAKRDGFSSKIWHKAVDGQGKTLVLIKTKDNFIFGGFTQVGFKHVQTGGEWIKDSNAFIFSLRNDKGDRKPEKFTIKKGEEPYAIHSHYTYYGPLFGRGADFRLVSNLQPGYSNFGYSYNLPNGIIWNPNEAQSYLAGSYNKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK97</accession>
    <name>A0A9Q0LK97_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK97"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="542" mass="62736" checksum="2FF8E3CB6A876C77" modified="2023-09-13" version="1">MNDCLFFGRNEYPKLIKNEPDKITKPIQFKFENENENENEKQIKQISTGGFSTIFLFKNGKAIEYLNQNPSKIQIEESIQKVTVSFENEAILTIEGNVFAKGRDINPKNPKEFINILSLIEDTNDRIIEDIVSGAYSVYLLTSNHNIYGIGSNHFGQLGFDSKTLKKTEKPILMMKNVSKIFSGNTSIHVFLLNSNQELFGCGYNGDTQVGLGESRKEEAKIEKLTKIQNIPKGKIIDIQCGYYHSIMLIENENQNQNPKRKLYSCGWSRYNGLGTNTYEFTEIKSSLFEDDDYILEISVGFEHTLILTSNSKLIVFGNNTYGQLGTGDTNNQTKSIPNQIELPKLRFNENISNYHISCGFGTSFIYYSSPPFSNLEEDLIKLFERKEFCNISFKTENGEIIEAHKLILKYRLNQNQNEIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYYEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILILRSELYRGMFLSVTEDKSNKVTDYSELSNESLFSIKSNKSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKE9</accession>
    <name>A0A9Q0LKE9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKE9"/>
    <dbReference type="OrthoDB" id="6142720at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="434" mass="51558" checksum="014A589A78F11DC2" modified="2023-09-13" version="1">MENYSNLEKLSNDLKNLFQNQNQNENQNENESYFDFQIICEQNKTSFKTHKSILSSRSQYFKSLFKTKMKEYQENKLILKDVSSSILSSILNYFYSGKIEINLENAIQILIFSSKYLIDELIQFSSNFIKKNLQFETIIDILKLSESMNLNQLLDSCYKFISQNFEEFSKTSFFLELEENHLNSILSNDEIPINEFELFQSIIKWGKYKSNINQEMNKKEKEKLQKQISNIINKIRFIHFSEQEFEDILKEDLIPKQISEKLTQFQKLQKQNDEKELNQFIEKENQNSLIFKTRFRLDSEIIQEKEHSKKLKEWINDNEFFSKMKKGYSAKEMDLIVKNGMIKNDKNDRKPEKFFIRKGKEKYAIQYFSSIWGPVFGKNGLDFCIGINLQPGDATFGRSYNLPKGIHYDTDEAKNYLAGSLSEWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKQ2</accession>
    <name>A0A9Q0LKQ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deneddylase 1 isoform c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKQ2"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.130">
        <property type="entry name" value="Ubiquitin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="516" mass="61004" checksum="4E031A5AC865A693" modified="2023-09-13" version="1">MDFPILENFNQNILWKEFQCSKTDLKRHLKVPNLKTIYPLKNKKIYLKCFSSNKILYEKINEINWVFGKYIIHSKENSCQEGYIPLDTIDIRNFQKISISSISQNENNLSQNSDSENQNDSSQEINTTSDQTSTTEYNSLDDQKISSLIENQKKRLELLNTQFKSIQNQSIKKIPQNSTIDLTKEDYSNDNDNDNNNFGNLFGNSNTQDEQEFSKIFKNIQSKYQNQNQKDLESLKMKKLADFVISILYDGIPDEIVIDLFGLQITRIQLINFFDKKHLIWEIASIFLKILQQNYPNCRIFDLNFYPRLKSFESLKKQEIKKLIPIQKGLLNFEKLIFPIFDQETSHFSLSVVDIRNRIFFNIDSLPNHEDLRSLHNVYKLLSSIANLYSKNTFKSGGIWDWKTRVDLERENILVPTQESEDQKIDDLINDYDDYDENESFDLKIPQNDSIVFMCFFAKLVVSNALDFTNKKIIFPEKYDHLRIRSEMIKKIWKFQQNQFDNPFQRSVYGNSLFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMN7</accession>
    <name>A0A9Q0LMN7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMN7"/>
    <dbReference type="OMA" id="ICEPNIK"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="306" mass="34754" checksum="8E5DB81F464B7D49" modified="2023-09-13" version="1">MEYLNQLDNQIEQLLSYEPLPEVEVKQLCSKVQELLLKEPNVVPISCPVTICGDIHGQFPDLLELFRITGKCPDTNFLFMGDYVDRGLYSIETVTCLIAMKVRYPSRITLLRGNHESRPITQVYGFYDECIKKYGNANVWKMLTDIFDYLPIGAVVNEKILCIHGGLSPSIQTLDQISRLDRFKEIPTEGSMCDLMWSDPNDISDGFGPSARGAGYTFGKDVSRKFNQRNGLTLTVRAHQLIMEGYSIHHDGAVVTLFSAPNYCMRCENKGAIMEVDDYMNRKFIQFETSPGTEKVISDQPPEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNB3</accession>
    <name>A0A9Q0LNB3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNB3"/>
    <dbReference type="OrthoDB" id="10644637at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37530" checksum="4160E90E9038F08E" modified="2023-09-13" version="1">MGNSQKINTVISLKKKRAYLRVFANSKEAIVIVDVSGSFVYVNSSSLELYQASSELELSMHKFLNLSAVNQPQLGVSSEQAEIKIINTVLNEPNQTTDFDWVLKTIKKKEICVHIWATLVDLAGDITLKFIIRPTINFLDPKVMKSQEIKFSTPQLLNIDENDLSSTDHFSSTENQTNQNPQKQILISLEDQDLEDTLENKIDEIKMTVRSSDDPDIELRIVKVLNSLHNLSTNWLSSKNTEIQKLSEKIQIERQSFRKKYQQLESHLQRRLDGYETERDVKKNVVSENKELKEKFHFLIKLIRDQFQVTEKLYSFYRSDLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNC2</accession>
    <name>A0A9Q0LNC2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNC2"/>
    <dbReference type="OMA" id="YQRQSMQ"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="333" mass="37912" checksum="C2F1608A7C06FE20" modified="2023-09-13" version="1">MKKTHKQIPQPIRVYRGHSESISSVRFISDNTIFASGSNDGEIRIWKSQSNQLVSIINSNSKKGILHIEKIDSSSFATQSRDGVIKLWNCENSDFISNFEFQTNSKFSFCKFSLSLDFSSLAIPSENPDEIELFDFKSGKKISKMQTEKSGMCMTLGFLKDQLFAGFENGKLYGFDTRMLSEDFIQPVSSLSCFEQPFLSLAISQKYETIFTGSVDPKFLLVQVSSENISQKDPFSDEKGGLILKDEIQLGHEGTSEICLRNDDQIFAFCGWDKRIRVFQFKNKTPKPLAILKFHTETVNSIHFSEDLLNGYLLAGSKDKKITLWQLYPKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNS7</accession>
    <name>A0A9Q0LNS7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_06501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNS7"/>
    <dbReference type="OMA" id="KFFVFPC"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="617"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="865"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="843"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="956"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5076222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1020" mass="119820" checksum="FDA4363BBB88AAE8" modified="2023-09-13" version="1">MTTLEDFNDSSSDQERIIEDEDIPDKILNTTIEQEQEEILEDDAPLFVLEQVKFNTSSEYVDMVAANQIIFIAFKDNKIMRLNLEDRSKITNLDFIPKKEENSIRKLFLDPYGAHLIINCTNGDNYYYYNTMEKPKILSKLKGISIESVAWNTEIKAPQRVTQEILIGDSKGTIYETSIDKKELYLKQLYQLEEQEPITGMYFQRYNTNSDLIFVIVTTPNRLREFIGKKTLEAVFEKYMTVKPGFHPFLGKLNYSELHIQKEKGYAHSFSWLTQSGIYHGTIDTSKRNIDPEKNNVISNASFVPYLIPTQANPPLSFVQTDYHFLFVFPEEFAAVCKLNQDIVVQLDKEFFDISEIGKLKAFAHDFTGDIIWLFSERGFYRIFVNNEKKDIWKIYLNQKQFEMAIESCSNDYQRNQVYKSQAKFHYANQEYNYAAALYAKTNIPFEKIVLKFLNIDNNALKDFLTHKIDAIGEQDFTQLKIICAWLTEIYLSSLNQIHLKIEELETEKKPKNEIEKLKEQFKQTLQDFKYFLVENKRHLNPEITYEMISKHGRIDILLDYALSVGDFERVISHHIQNENYKEALKVIQGQKSDEIIYKYSPILMNHLPVETVDLWILKASNLNTVSLLPAIMRYDPAKNPSHVKSNQAIRYLEFCVKQLHNRDPTIHNFLLALYASNNQDSELLNFLNMEIHQTFYDLKYALRLCTKYRKKDACVYIYSQMGLYEEAVDLALNDNYMKEKNPKRKNINEKNFNNENIKNQNDIQFEDNQEKEIKDIKLATINALKPEDDDLKKQLLLKIARDLMEKQKNIKKAIEFIDEHEQISIEDLLPLFPNSVKIDDFKDQIKKTLDNYISKIRNLKQEMDSTTKSTDIIREDIKLLRDRYSTINPNPRCDLCGTSILNKDFCFFNCGHLFHTSCLQNELLEKNLVSNSKKKRILELNQMIINEQSKHQSDNKNTNQNQPQKPSIDKTQEYIQHLKLELHKMITFDCVICGEVVIKTIDMPFFDEENQSLINSWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQD6</accession>
    <name>A0A9Q0LQD6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras di-ras and rheb family members of small gtpase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQD6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="295"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="403" mass="47467" checksum="5C3291CA50BAB5A8" modified="2023-09-13" version="1">METDGKKIRISIFGTEGTGRQSIALRFCNNAFLEVPNRMNTSSFQKKTVFQDRTIFFEIIVYSKDHYGSDFPIYYAPSSDCVFFIYSIESEKSFEEIASICGTFQNSIKDMEKFELIPKILVANKKDLENERKIPFKQGQDLAYQYGMHFTEVSTKTNENIDSLFEKAALEVLRTNNYLFEFLRTFQQEMIQFLERKELSDFSFEFDSQNEEPIPLHSLILKYRIGNDFEAKLEKLKNQEKKDVVQFLSLIYSGLERYNNSKIQELSKETGIEIKIGREKLIEDMKKLYLDQESKDFSIMIQEKEIKVHKIILALRSEVYREMFNKVLDDSGKVKDYTNSKFKTFQTLIQFFYTDTIEENISLETIQELKNAEDFYQLNSKSSLQPQLEHFESKKKGKSCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQI9</accession>
    <name>A0A9Q0LQI9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQI9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="196" mass="23854" checksum="5E74811F75AD456B" modified="2023-09-13" version="1">MKLDFCKFYYKFGNCKVNNCKFQHINANKISEKQYPNQYPNQYPNQYPNQFTNQYPNQYTNQNQNQNQNQNPIPNQYQYQYQYSSPTRFQNPIPIPIPDPNLKKFEFPNPNLMNQQFSQMNVSNSNVIESDKKKHKHKHKHKHKKEEERDRSPRHKNKERTKEKKHHKHHSHHNHSKSHKNKNKNESENGVEKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQQ4</accession>
    <name>A0A9Q0LQQ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein lin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQQ4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="501" mass="60038" checksum="F3D84729A94E8054" modified="2023-09-13" version="1">MNNSLNVFWNEQEIRAFYKNYRKFGCFWNRYNDLPRKTPEMMKIFFQKHHRVLDSNQFSENLFVSLIKDDDFFKESTQNTLIIPQENDSIKMQIEENLNLTEEIQKSIKKKDPNFPFLHFNFPDRKYLIHSKEMKQKNESKELMIESKQKKNEKFILIKEKQEEKQEEKQKEKQKEKQKEKQEEKQKNIEMEIESQKDSKSMHLKKVKTRVNLPKKNRFQVESLPQENNDNKQKEIQDKKQQNKNEIQQTEKNPIQRGYSKNNRKFQKLQHAQSSWLEKLSGQISSDRIRKFCICEWFVADSIIPFFEDSKVKKKLQTKSGNFRKELTKLEWRILKTQLFEKELSNNSQQILVNAKKKQYYKYSPVELSNLLKIESSGLIPLPIGDIIRPPVKASFLNIKRQAIQNKINSEILIQNDPSRKVDFKKEIQLFQQSSPQIIPIQSLKTNSKIGIYNNLRKFSAKVKSKQKNQIEIKFQDENLSNISFDEIILKNLKVLYLEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR19</accession>
    <name>A0A9Q0LR19_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR19"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF70">
        <property type="entry name" value="SECRETION-REGULATING GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="147"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="260"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="390"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="603" mass="70223" checksum="DBD2AA650C3BD546" modified="2023-09-13" version="1">MNEILFFGSNYSKIFKNKPNEITKPIQFKFENENENEKQIKQISSGSYSTIFLFKNGKAIEYSKEDDSNQNPEKIQIEENIQKVTVGDQNEAILTIEGNVFASGEDINPNNPNEFINISSLIEDKNDRVIQDIVCGADSIYLITSNQNAYGIGSNDYGQLGLDSKTLKRTEKPILMMKNVSKIFSGNNSNSVFLLNSNQELFGCGYNYYGELGLGESRKETKIQKLTKIQNIPKGKIIDIQCGSLYSIMLIENQNKNPKRKIYSTGDSKYLELGKNQKIYEFTEIKSSLFENDNILDFSVGFSHTLILTSKGKLIGFGNNQYGQLGNGVTNNKLILIPIQIELPKLRFNEDISNYHLSCGYHKSFLYYSFHSFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNQNQNQKLQEIISNKSIKESNQIFEMIYSNRITNPKLYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIEEIQIGIDYFQLNQTNPNLFDLLINKFNNQNWNQNQNQNQKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRA6</accession>
    <name>A0A9Q0LRA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRA6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="74" mass="8879" checksum="0CE15574B8ACAEA3" modified="2023-09-13" version="1">MNQSKQPQKKQVVVKKKPQQRKDVKSVENFYAGCSTEEERKQRRDFADEHFLQRPVSPPPFLFEKEDDQEDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRB2</accession>
    <name>A0A9Q0LRB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-secretase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRB2"/>
    <dbReference type="OrthoDB" id="19866at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="1">
        <location>
            <begin position="694"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="905" mass="106991" checksum="DA03E8F270B45F40" modified="2023-09-13" version="1">MLNFRLILNFSTPMKRETTLRTLETEQKDNLLSMKKKENSQITEQFFFIGQESNNKLLILRYIQDDESSPTTIIDLVDLTTKTRKTLFSKKPIMSIVGASLSIDSSFLLITMKFTHQIKHSKQILLDKPKYQIFLVELKNNSQFREITKLSYQYQRAFFISKKDESKKQTILVIIDQKIVQVIQIGMKSETKKGNNIKLITKIKNTETICEEFLWYQWNPQHEQLFLLKQGKSADKNELICYSFHHKQTKVILTTEFEIIENNIESKMNKFDYFHDNNMHGLYPPSLSFQFYIAKISRGNFCLCRQQITTQDQKKFLQISIWILYRRERIDVSIPIKDVSKAENAHVIFSSIYELLIIYVPGMCLEFFDCTILHDPIKPVHFEEEEYVTSFFDSASYLCPIELHKKKTYIPNENFVINNLNGKLYSFNIALGVLKHVFLQRNSELSSFIAHICFTHFNNPKFADALFDLICKAEPTCITPKLVQEYLIASTFQILFIKQNMPSKLIEHRKLFLSTIPMTQSKPFKNSLTFISQENCAKDIQIQTHNFQDKNPISYVNYQRIDFSKLLEELTKNEIQKEFPEEENEIDEERTQTAGIFSASQLKQIFKNRFLESIEKTTKNKKQIAEELTTLYYKTISMQIEKIFHFVVVNLIQEFSNLVITPSENKMLQFSSRRNQDINSKINSECQNQDLKNTILAQLRLKQRQVFDVLEKFYMALEEFSLPFPNHFHYYFCRLGFSCLPRELFLQHLDRNIFRVDSGFISDLIKPKRKNDTELLNSTVEKLQKTEDIIKILIKYKDSQNIRNLIEFYSREISHDYISLIESQNHKLSNSDLFHLQTEKIEDIEFSPLEIAIERIEKINNENLFSPIIFISENYKQSYDFHVGFLENEMNNQNNQQNEFNNQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRG0</accession>
    <name>A0A9Q0LRG0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRG0"/>
    <dbReference type="OMA" id="QPAKCGA"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5075905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="189" mass="21346" checksum="4229386586FF7F7B" modified="2023-09-13" version="1">MSNENISPMVLKRVMKELAELNKTPLDGIKIIFEEDNISEIHAIIQGPEKTPYEGGNFTMKLVLSSDFPHSAPKGYFITKIFHPNVSKTGEICVNTIKRDWSPNLGIKHIFLVIKCLLINPNPESALNEEAGKLILENYEEFSKYAKLMTQIHAIKKTDSNIQTNSKTNSKSKSKSKSNQIKKNKSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRP6</accession>
    <name>A0A9Q0LRP6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1526" mass="175896" checksum="B65979994E5E986D" modified="2023-09-13" version="1">MTNINSALHLLKHKKYEPAIIAFNKLIKKTPNDAQLFYHRGNCELGLNKQEEAIKDFTTAITLDLRNTDYYIARGDSYTETKQYEKAIEDYSKVITNLKEDHSILNTRGITYFKMGEYEKSIADFTEAIKINSGIHSYWHNRGYSYYLMENHERAIEDFSMAVKLNPQDEESFNNRGLCYFYMKENKKAIQDYSEAIRISPKVWVFYDNRGSALFKDSRIDDAIADFKAALKLNADSGNVLCHLATALQKKGSYDEALDTLAKALRIDPHNPALYAQRGEVYRLVGNLQKAADDYLLAISILPDDPRLFFGLGKIFSDLKDHKNALVYLTKACELAPDEEEYVFSRAMVWMGFGRYDYARADFERVYEINSNSIDSIVRIGMCYYKQHKFPQALEVFSRAAEKHGENCTDAYYLSARIYEKQKRYKEALEQISQCIKTEGLKPRSLLVRGRVLYKMRNFADAAKDFSVVLEAEPSMKTHILRIKAYLYHNHTKSLEDLDAAFKLYGDHHMLRLLRGKMLFKMDRFADSVSEFTNAIATRKNFAPFYFYRGLSFHKQSELDKALADISSAIALDPKSHKYRHSRAFVFFEKNMFRECISDFVFSAPSYLDDPDFHLNLGVAHWSVGQIRKSVSDFSRAIALKNDDPELFEFRARSHYKTSNFEAAVADYTAMIKLAPKSPAGYLGRSRAYMGLGSFHHAANDLNIVLTSEPENPKCLFFRGRCFIAMNKLSKALDDLALSIKFRVNVQFWYRSLVHFLLGNQKLAIQDATSAIEQTKYLSSCYSLRGLVFLCKYESCILGISTDKKIQKIQKIEKIQKIQKIQKIENSLSLEIIKAEAEEDFLESILLKDEKFPVSMSKAHLTFLASEYKTAISRYTAVLAKIKSKPFRPYLFFLRASCFFHLGLLNSAVDDLHASLLASNFVFRLPALLADNIFNLLSEKIPSCYSQSNITELSITLSSLTKLIKTRKPQEQSLSILSNNLLNSVLLPEISLLQNSPQKFNLIEKFLPILEILSPSIAFPDPLSDPLTKLFNPSTILALNSPPFLFHLLLFFLPKSNSPLKISFENDIFPEIIDTFHSWSPRSQELFLLALQFIDTSKMSDPNKQILFSFLIHFLDHTFPDRVVQCFFACLNKILFEFSQENKSQLLSSLLSFMQPTSGFRLLHARIFQFITSHFSFALLSSFFPQFITSYTTNSSLLDASSHRIILSSITRPNLVSLGAEKLSVLIKHFFRIWLEFPNLRSIIQILFDWSFSEMVKNINQLKPALDEFAKALLSQIQIPGTNRPDAVRLFTNFAQHRQYSSKEFTTLFLSPLTLILASPMQPQPFYDSLSFCLYTLFVLVPDYQEPIKNFLDDLPKNSILFVPVHRIIKKQLNALFNVIEDCLDDISVLHFIIYLLNTPEARNFFPLFFKYSLNLYKNYSISKRKKLLVFLEDLLFSSQENISLFDVLLDLCNVFSQEEFIPLKWLIAKLILEIESKNFLKFLSEKKQPVINNLIQELDSVAKFFYSLKPFMGFGLFEFDFSDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRU4</accession>
    <name>A0A9Q0LRU4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Androgen-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_05528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRU4"/>
    <dbReference type="OMA" id="ISYFWIS"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5077838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="222" mass="26236" checksum="42FB8597BB818F8C" modified="2023-09-13" version="1">MNFKRIFLFNFHLFIVIASTISYFWISSITTFGIRSLQFYTIWNLLTVLFFYAKNLYKDIQLFRTGKTSDSSTSLLTLVFVMNIIMEIVFWSLTLYDPTLILPKTFVIPPVLNHFLHTFPLFYDFIEIFFLPEYFAKMSSKYLDFLFVLLLALGYALVSFSVTFIYGDVIYPFLSMMSPLFFFIFFLVATIFAYSFVMLSRKLISTGISRNLKKKEEEKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRV5</accession>
    <name>A0A9Q0LRV5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRV5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="76" mass="9100" checksum="0948957A28D95CC3" modified="2023-09-13" version="1">MEVMIMIGGLFIHIYGDKRKLQERKIVKVGDMIIKINISKQKENQIKNQNQNQLIKHQYQYGNSKINIKIKNQRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS19</accession>
    <name>A0A9Q0LS19_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rab7l1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS19"/>
    <dbReference type="OMA" id="NNFIGWT"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001800">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="22924" checksum="7C238466CEE6EBCF" modified="2023-09-13" version="1">MTDMLYHKIIVIGSSGCGKTSIIKRYTGSPFSNNYKATIGVDFVEVSVEVDDQQVHLQLWDIAGQERYGLMKTLYYKKSSAAIVVFDITRKNTFEEAKKWRDDVVEKVALSNGVPVPIMLLANKCDLKTQAIPDQEIEEFSTTNEFFAWFKTSAKENLNISNAMTTLAKHIVKTQVPEPRSEGFHLVDPPQRIKNQRKGGCCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS52</accession>
    <name>A0A9Q0LS52_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Karyopherin (Importin) beta 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS52"/>
    <dbReference type="OMA" id="CERMSHE"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1034" mass="121340" checksum="61C038DC3A5F2BBF" modified="2023-09-13" version="1">MQNFNNLENILLKILSPNNEERKNSEQKYWDLCDFSTQEMILKLISTFEITKHLPVKLLSMVLLRQIFYKDIFQENESEKNWNKFSQDQQNSIIEKLIQFLNLDEKIIVKRKVCDLIVILVQDFDETTWQQMFKFILDQLQDSNIKDLMLYLLEQIVFYSPSIFENITNELFQIQSNFIHENNPFQIRLLSFNLICSQVQIAKKNERDSLKIASFFNSKFLVTFIEKADQNLLENFNEDILRNLILLPIEMMLEIEENEDWENEELLPSSFKTAQTNLQIISKTFQEPILSIISSILQELFSSQNWKNIIVGLGIISAISEGIPNILVDQVQEIVQEIQPFSQNSNPRILYQLYLSISQICIHLSPQAQKKTNQILIPIISLGINQMNYPKIQIAALDALIDFCYYSSSNTILTPFAQEILENLMQLISCDIIEVQEKIITAISFIAQASKNQFEQYYHSLMDFLKRIYLLANKIEFQTLKAKTFLCMGLIGNAVGKPVFAKDAIEIMESFDSNDFSFEENSQCTLYILRSWKKILNILNTDFYPFLQKIFPIVFQQAAKQPDMFLVTPFNESHLDPKDHDFIILGDQKIAIRNSSIKEKYQSLKIIDQVVDIFSEIPFEFIQETQNIIISNYTFIYDENIRIICAEITIKLLKIYLNLQNKQNVNQDELFKNIHSLLLQIFQYLSIAINQEIEPRVIQMFTWSFKKLLKLSQNTFGSDFLEPFIQILFNIIKEGFERISRIFNNNDSPDLEMEKIIKQSTKTERWIQFNISKILSLINIFHHNHFIQINGNGLFDLFKNYLIPNQLNSPVIQEFLIDFILILLNSDEPQLIQPIISEWTPYIISNSNISNYFVSKKFVDFINLFSTKYTQLFLPFAQDSLIRLHLFISSDFQHFPQKLIEEVQDLHDFAIFVFGNVCKNSHQTIDFQDSFHNWLIQIPLLVNNTSTNQIYQLFWEFIETKNEQVFGQDLSQLPIILSIIANSFSFPSQIIEESVLSNFVMFLKELKENLSEDQFSQLMNSLEPQLSSKLTNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS87</accession>
    <name>A0A9Q0LS87_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="MFITHIS"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="625"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1345" mass="155644" checksum="27408CC4C5890E3E" modified="2023-09-13" version="1">MEYLCSVENNHQVRVNGFKMLLYLIDAQEEETDAKCKELLKNAVSLQPFLGEYPQNSVTLKTKLIQVEGISTKVKCTNSAKENIELFDLLMSFITNTASNKTMWLEILKKEFITSFYPNICQELNIIDKDDTSGFKTHYQKMSSVLFDNLENTQIVVEIFRQALLLSTQHESTVTESISQYEKWFLNKEKPHLIRAQLQSYFRMFITHISDAIRISTTSNDLEVLSARFIKMISIFEKISQEENDYLSSLTWKFLLEKVVDLITAIARSMNANADILKIFEMIVGNLYGTLFTIWVNSRTTQRFLWCKLKELFAITREQFPVVVQWKRTLLKLTGMLHHFLYNTKEKILTQKEEAEISRRSSDILFLKLDSDSRNKNTFEPEKDVQLLPTTTQEEKSIPYFLMFRENNWNNKIGLFFWANIFHLIGNIDTIQNSDIKTYCMASYVEIYDALFRIKHLIPDSIYSMDPPINELFIPIFLESVSYDDKFKKARNIGCGGFSIMLCHTHIPLSEEMLSYFYLGLAKALSLTDHELTSTILRYTSHLFGYCFPGVNCLINAYLSRLEIFFNPNYQKPIDDNIYIHGIALLSSLICIQDQFSNAEIFDITNLMNLHKETWPDFVQIQTEYTNEIQQREEFASNLDEAKEEKEKIIQNEKERQQKTKENWEKKNIFKDIQFLFDSNEQIRFRILKILSGIVSKNKSDSVTNYVLSVICSLCVAELKTPSLKTFPIVEESISIFLRHISHESEVVSQMSSNYISILAKFSEQIHKLNKDFVPSIITKLSNKIIEELGQVSNNKIKGILPNTYFGFESLVQLLINSSCLLEESQTPSLVFQSTVNALSKFNNNIGNFEVTIQNKSKRSLEDISQNLLFRSLNYMNNFPFLEGPEVISSRIKEGEHDIDTKDQKITQYTQAFSFGTNTLIIAHKLPDSDGRKIRITIRDSTGKYTWDLENILNLDDGIMQKSIDLKKRPLPKIHQNGSDINLKPFARSKANIPEYTDGIDISNVNVFHEMLDYIHEKFNEKIEQKVKKNEQLISDYNNQTSKVEEAIKSLPKTTTTIANAKETEPTVPENLSHFCRLFLSHIGMINLQNHNQLVQLAHNEKLFKSIQQLDSISERQTFSVGVIFQGREQRTALELVSNENGSPLYEEFVNCLGWDVDFEYHLGFSGEFPSLKKATVIFPYFANSELEMVFHVLTRIPNDPQDEKQNQKKQMLSKFPVNIVWCESERDYSQLILPSAGLYSTIIVYPLPNGMFRIQVLIKTKNPFYGPTIDAMILNKASLPFLIRESIIVANKFFILQNQDSKEQITKRKDLIRQIIQQSQLQPPFTNYHAANVIGKSHSENSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSH0</accession>
    <name>A0A9Q0LSH0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSH0"/>
    <dbReference type="OMA" id="YACIKNA"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="345" mass="40681" checksum="30475B8BE88AC2AE" modified="2023-09-13" version="1">MEDEKPKNIEQENTNLNIKPIKINVGGKIFETLTTTLLKWKNSKFEEIITNQKQFPIINDGIIFFDRNPKYFEIILDYLRTSEITIPTKLENKKGLEILIKESKYYSIHSLTQLLNEKFEVFKRQTFTPKEFRKCIQHSESNTPIQHYGSNTALYPILDTKRIERQDLTGFSFSTIRFKNFEFIDCLFGPSTYFDTNFENCKFDGSRFEQVIFTAPSMMRPKFEKCSFQNVEFVNVNFPNNVSFQNHNFKGSVFKFCKLIKSNFSKSNFDNSSFIDCKFDKCDFSGCEMNNICIPEKQFKSCNTKGAKVKNLIDISKDKTKIKEIKEWNEILSNIDKWKQHKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSW5</accession>
    <name>A0A9Q0LSW5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSW5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="492"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69860" checksum="F1FB5F6A39FA6FF0" modified="2023-09-13" version="1">MNEIIFFGSNKNPKFFFDGPDSIKKPIQFKFEIENENENENENENEKQIKQIITNEFETIFLFENGKAIEYLRDSIRNPQKIQIEENIQKVTVGISNEAILTKEGNVFAKGKDINPNNPKEFINISSLIEDPKDRIIQDIACGYYSIYLLTSNQNVYGIGSNQFSQLGLDSKTLRKTQKPILMMKNVSKIFSGNFSDSVFLLNSNQELLCCGNNDYGKLGLGESRNETEIQELTKIQNIPKGKIIDIQCGFYHSIMLIENENQNQNPKRKLYSCGYYQDNGLGKNEDTYEFTEIKSSLFENDDIILDFSVRGEHTLILAEKAKLIGFGNNSYYQLGTGDTKSQKIPIQIELPKLRFNEDISNYHISCGFSNSFLYYSPPPFSNLEEDLIKLFRRKEFCDISFKTKNEEIIKAHKLILKYRLNQNQNQIEQLKEIISKKSIQESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELNNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU82</accession>
    <name>A0A9Q0LU82_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_14603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000037">
        <property type="protein sequence ID" value="KAJ5079127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU82"/>
    <dbReference type="OMA" id="YQEIKMH"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="205"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5079127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="35147" checksum="964A6FEBC1F6754D" modified="2023-09-13" version="1">MERDYIAKVLFNPVTKSIIMIQDKKVIGGVSFRPFLEQKFAEIVFLAVSSKSQNKGLGRTILAHLKTYCRSELQIFDLLTYADNKATGFFQKQGFSNRIRIDPKRWKGYIKDYELSTLMHCVIYPKVDYLKLNETIEQQKQNLYHLIQVISNRQIFYSGLCFSEEVKEIPFDKIPGIDKEFATQIKNQYSLQLKPSLKELVDYLKNHPSIWPFLQPVDPHFAPDYDKVVKNPIDLSIIEKKVENLEYFDQIHFIEDIELMCRNCFLYNNKETVFYQSGQAILIAFRKKVKSMKKAKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUM0</accession>
    <name>A0A9Q0LUM0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUM0"/>
    <dbReference type="OrthoDB" id="73037at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="138" mass="15890" checksum="9D49ED90459AC5CF" modified="2023-09-13" version="1">MNNFPNNQFVQMLGIMALGDLGYLNKKNQNEILEKKGIETIINSMNNFTNNQGIQFYGCETLKDIISFDQRNENEIMKLKGIETIIKSMNNFPNIQQIQKNGCQILGNLSFQNEKIQNEIVENKGIETIIKLMNNFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUQ9</accession>
    <name>A0A9Q0LUQ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUQ9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="150" mass="18114" checksum="79876A3EBECC2188" modified="2023-09-13" version="1">MIYSNNSKINPKLYSEIKEIINSNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDDIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW35</accession>
    <name>A0A9Q0LW35_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000020">
        <property type="protein sequence ID" value="KAJ5079942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW35"/>
    <dbReference type="OrthoDB" id="18070at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="217" mass="25523" checksum="C744E762E323AB4E" modified="2023-09-13" version="1">MDMILPHLNFNETILTFLETLIINENHKYTGFEMDLFLLDYMLHPKEFLPIHPIKGKSKSKKESQKQEVQKMNLLGSKKPSKQVEIVDDYPIVLVCSKWLQVLPWEELFEQNTVRSFSGLKFANLEQISNDEELGMVAQPHYFTCYSLPEISKKFTIQKIRQQQKSIYKELVFNLHHSDNPNLNGKESQNKPPFHSPLVKYGTPKKTLEKITKYYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX36</accession>
    <name>A0A9Q0LX36_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von willebrand factor a domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000003">
        <property type="protein sequence ID" value="KAJ5080718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX36"/>
    <dbReference type="OMA" id="KAKHSHF"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="250"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="927" mass="105412" checksum="88BEDC30B332213A" modified="2023-09-13" version="1">MVKLGLINKKTEENVPLRGVSVTANIKLIFVFPLDPECSICGFEVFMEGKHVIGEVKEKEKAKDKYDDAIAQGHTAIKMEQEIEGVFNMSVGNIPPEKQCIVTIRYVTELIATENKELRFFLPTTITPPFVPNEMEINDVTPLLETNYTPKVTFGLSLNLNVTMASEITNIKSQSHEISSQINKKFATVTLLSDPKESFSKDFEVLIEVSEPHQPRAIIQYEKTKNEEEKEYAALLSFYPDLSEKDVRTELIFLIDRSGSMSGSPIRSVAETLKIFLHAIPETCVFNIIGFGSKYKTLFPESETYSQKSLEKAKEHANKLKANLGGTSLLGPLKYIFSKEPKTGYARQVFLLTDGEVYNTDEIINLVRFQSSTTRVFTFGVGASASRALVSGIAEAGGGKAEFIVNNEDIRPSVMRQLKRALQPAITNVKIEWKGTKPDIVVPYRLPSIFAETRLLVYALLKNGEEVEATLRGISSEKKVEWKMKLNPKEDGIEGKSIHCLAARKMIKDLENKISQFHDENGKVITGKTEKDIDKKIIELSTKAGVMSSKTSFISVVKDLEQDSNEQDLGEMITRKISVQQTETNIYNQNSVPVIPINSWKLHPSQTNRGILLSQNNQNSNNYLLPPDPNSNSFHNQNQYQHQYQNLNFNQNLNFNQNFNQYRKFSQLHNRNQNFNQFHNFNQFHNQNQYQPQYQNQNSLNYSLQNQYNNSLPQNSHIHHSKAKHSHFHHSKAKHSHFHHSKAKHSHSRDYKMSENHSKHKNKHKNKHKKKNKNKNQKSESESKSKSESKSKSKSKSKSKSKSESKSESKSKSKSKSKESSKPTKPTQPSGNLYKVIDLQNADGSFPLSSSFISLMGIDKKKITDNIPKDISEIIWATAIALAYFEIFFNDKSIEWELIAKKASNWIGKNCKTMKADELKQKAKQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXA1</accession>
    <name>A0A9Q0LXA1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000036">
        <property type="protein sequence ID" value="KAJ5079133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXA1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040413280" evidence="1">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="104" mass="12221" checksum="3D66A5D836DA602A" modified="2023-09-13" version="1">MKLNLFFSFFFFLIINIFLIQSNQNKNQKSIQSSLISISPILTEIKTLTETTRYYSSFNEAWIWNLLDQFSVYEDVIVVGAHGAKQAFIYRYNGTILESRTNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXF9</accession>
    <name>A0A9Q0LXF9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXF9"/>
    <dbReference type="OMA" id="MGFEMFC"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="12"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5080329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="382" mass="43444" checksum="57D1D2A61FA0380F" modified="2023-09-13" version="1">MKALYEACEDKNKADLSIGEYKDGEGKSMVLNVVREVETDISERDDLTKDYLPIAGDREFCHYAEKLVFGSKCKALNENRICSVQSIGGTGGVRLAAELIKKCAPKKIIYIPDPTWVNHKSIFTRCSLEIREYGYFKNGFDFLHLIKDLKAAEEGSFILLHACAHNPTGTDPMPDEWKQIFDILQEKNITPVFDSAYLGFATGNYQKDALAIREAVSRGIPCLVAQSFSKNLGLYSDRVGCLSVVCDSEKEAENVFSQLKAIIRPMYSNPPTHGSLIAGTIFANPFLIRKWKSEMKGMSKRIKDMRQLLYRELHRKKTKRSWDQVIQQIGMFSYLDLEKEHIEKLRNEYHIFMSPSGRASISGVNYGNINYIVKSIHTVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXR7</accession>
    <name>A0A9Q0LXR7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXR7"/>
    <dbReference type="OrthoDB" id="27341at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="174" mass="20359" checksum="D0D966B90E564219" modified="2023-09-13" version="1">MKKLKEWIPNEEFFNKMKIGFSLQKDGFSRKKDKSPRKKDKSPRKKDGFPAQKFHSKCDNKGETLVIIQTTDKYIFGGFLEIGFPSGDFRYLKDPNAFIFSLKNPNNNIPQKFKIQEGKEDYAIRYNRNDGPRFDFGATYSLPNGLVHGTDEARNYLAGSFKDWKIEEMEIYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY17</accession>
    <name>A0A9Q0LY17_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000028">
        <property type="protein sequence ID" value="KAJ5079523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY17"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="160" mass="19279" checksum="3697B1F877F545EB" modified="2023-09-13" version="1">MEVENQKEKITLKRLNEIISHFEIAIKFFSHQKFLNDFIEIRIYLAKLYLKYAEICHENIKLKKFIIGFKNFLDIQSCFPLNQELLQNLTKNQMFSKLESYLHSFLQKIINFLSSSQKFKKLNDSFKEIYKFSLINKGKTEIIFKELEKVIKNINNLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYU3</accession>
    <name>A0A9Q0LYU3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammecr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYU3"/>
    <dbReference type="OMA" id="GTHTHGN"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="198" mass="22995" checksum="0039A146B88486B7" modified="2023-09-13" version="1">MTEIIATKEMCYFAFETLLSQFDKKFKMEKYSFSEKVSCPLFVTLKKAAKGSLKLRGCIGTFEDKPLESGLREFTKEAAFRDPRFSKLENKEIPSLTIGISLLINFEKAQNYLDWEVGKHGIRISLDGYGATFLPEVAPEQGWDKETTIFYLVRKSHYYGDLDHDAKNRIQLTRYQSSKISASYEEYLDWKKKMESNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZV7</accession>
    <name>A0A9Q0LZV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZV7"/>
    <dbReference type="OMA" id="VIDMAYQ"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="66"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5080330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="443" mass="50650" checksum="DB3F1AA6401ADEDB" modified="2023-09-13" version="1">MLSLITKSDIVNKQIMNTLINTIKQDLRSKTEQIKSNFQPFAKIQPLPPDKIFHMKALYEACEDKNKADLSIGEYKDGEGKSMVLKVVREVEIDISERDDLTKDYLPIAGDRKFCHYAEKLVFGSKCKALNENRICSVQSIGGTGGVRLAAELIKKCAPKKIIYIPDPTWINHKSIFTRCSLEIREYGYFKNGFDFLHLIKDLKAAEEGSFILLHACAHNPTGTDPMPDEWKQIFDILKEKNITPVFDSAYLGFATGNYQKDALAIREAVSRGIPCLVAQSFSKNLGLYSDRVGCLSVVCDSEKEAENVFSQLKAIIRPMYSNPPTHGSLIAGTIFSNTFLIRKWKSEMKEMSKRIKDMRQLLYRELHRKKTKRSWDQVIQQIGMFSYLDLEKEHIEKLRNEYHIFMSPSGRASISGVNYGNINYIVKSIHQVLENEHFIANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4U8</accession>
    <name>A0A9Q0R4U8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyubiquitin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4U8"/>
    <dbReference type="OMA" id="VHENTRR"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000009">
        <property type="entry name" value="Ubiquitin-60S ribosomal protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="157"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="310" mass="35229" checksum="566A40AD26496238" modified="2023-09-13" version="1">MNFQIFVKTLTGRTITLDVDSNDSIENIKSKIQEKEGISPEQQRLIFAGKQLEDSRTLNDYSIQKDSTIHLVLRLRGGNFQIFVKTLTGRTITLDVDPNDSIENIKSKIQEKEGISSEQQRLIFAGKQLEDSRTLNDYSIQKESTIHLVLRLRGGNFQIFVKTLTGRTITLDVDSNDSIENIKSKIQEKEGISSEQQRLIFAGKQLEDSRTLNDYSIQKDSTIHLVLRLRGGNFQIFVKTLTGRTITLDVDSNDSIENIKSKIQEKEGISPEQQRLIFAGKQLEDSRTLNDYSVQKDSTIHLVLRLRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5D0</accession>
    <name>A0A9Q0R5D0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transient receptor potential cation channel subfamily a member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5D0"/>
    <dbReference type="OMA" id="CLNGHDK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="565"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="705"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="859" mass="97425" checksum="AF961332C05EC0E7" modified="2023-09-13" version="1">MQKPNISLEIIKYLISKGIDINSKTNQNETALHYACQNPNISLEIIKYLISKGININSKTKQNETALHYAYKNQNISFEIIEYLILKGIDVNPKTKQNKEVLDYFCNNSTNEIIKYLISKGIDINSITKQNETILHIACLNPNISLPIIKYLISSGIDINSKTNQNKTVLHYTCKNPNISFEIIKYLISKGIDINSKTNQNETILHNACLNPNISLEIIKYLISSGIDINSKTNQNETALHIACQNQNISLEIIKYLISSGIDINSKTNQNETVLHIACQNQNISLEIIEYLISSGIDINSKTNQNETVLHIAFLHIACLNPNISFEIIKYLISSGIDINSKTNQNETILHIACLNPNISLEIIKYLISSGIDINSKTNQNETVLHIACKNPNISLEIIKYLISSGIDINSKTNQNETVLHIACKNQNISLEIIEYLISSGIDINSITKEKKKTALHYACKQKNISFEIIEYLISKGININSKTNKNLTILHYACLNPNISLEIIEYLISSRIDINSKTNKNETVLHYTCQNQNISLEIIKYLISSGIDINSKTNKNETILHYACKNSILHIACKNPNISLEIIEYLISKGIDINSKTNQNLTILHIACLNSSISLEIIEYLISSGIDINSKTNKNETVLHIACKNSSISLEIIEYLISKGIDINSKTNKNETALHSTCLNPNISFEIIKYLISSGIDINSKTNQNETALHIALKNKYPNKIIKYLISSGIDINSKTNKNKTALYYACQNKNISLMKLLMINGGNVFDLKENEINQEMIDLFRKIYSFNEDLNNFLKSNEFKDIEIKCNDGEIIKVHHLILLTRFDNNQTNFNKIYQYLQKKTKKRYSISFKFSLYWIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R701</accession>
    <name>A0A9Q0R701_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R701"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="282"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="426"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="862" mass="101221" checksum="42A583A70C9CBF91" modified="2023-09-13" version="1">MSKKDWTLFPSQIGSFFKSSAQSAIQWGQKQINLVTETETEKDKEKDKEKEKEKEKEKEKHKEKDKEKDKEKDKEKEKHKETETEKHIENENENQNQNQIQNKNQNQNQNQNQNKNQNQNKNQNQNQNKNQNQIKNQNQNQNQNQNQNQNQNQNQNQNQNQIENQIQIENQNQNQNQNQIKIKIKIKIKIKIKIKFKIKIKIKIKIKFKIKIKFKIKIKIKIKIKIKIKIKIKIKIKIKIKFKIKIKMKKNLVKNVVYEKVKQFGETIESSFQQNFAEEFIDYVTSSGYHAQNHKVITRDFYELCLFSIDKKNTEMNPAKVVLLQHGFLDNAFSWIINGKNSSLAFLLANNGFTVFLANSRGNGISNKHLTLKTKDSDYWKFSWEDMAKFDIPAVVDYILTFTGAKTLTYIGHGQGASILLVALCLDQEVKNSNQNQNQIQNQNQNQNQIENQNQNQNQIQNQNQNQIENQIENKIENKIENENKIENQIENQIENQIENQIENKIENKIENKIENQIENQIENQNQNQNQNQNRKSIENKIENQIENQNQNQNQNQNQNENKIEHNYFSSLSSKINLFIALAPMCSLYSTKNKLLRKLSSFSNDSLFLTLGYKEFKADSEILLQINNRIEKQNKTESKSQIESKLQTEPKLQTESKLQTESKSKIESKSKTESKLQTESKSKIEPKLQTESKSKIESKLQTESKPKTESKSKTESKSELKPTHLFHFLDGQNIYQQRIEIYESYLLGKTSVMNLKHWIMMINSKNFLKFADLDSNNQKLSQSSSEYNLGLIDECCPPIAVFYGKLDELSTPNDIESSLLSKLGKKPFYIEKNEEFGHIDYLLARKVTRKIYIKILAILRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R832</accession>
    <name>A0A9Q0R832_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R832"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="280" mass="31641" checksum="0B1A81CB68098894" modified="2023-09-13" version="1">MKKTKINSLVKNYADGLTISCGILACFIFAFVFFQSIFFPGKVYCNDYSCPNKLNPKVNRILVIVISCIFDVFVILIGIPILNSPGHALKNAKRTKGVFILIFGLIPFSFFQSIFPEIEKGYVATYYSAHNYSVEITLKTGSSAEVNFTNIFSEYTSSMTGMVVVYEATGDEVGIYDLSPVAHQVYRDKKKDSSFEITSSVTSISREISNLEDSKYYMWTIIPAKIISDKTYPADRPWTSTKYSINFASGYNVSDAFVDRRIYRLCKWSSYNGCEYSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8J9</accession>
    <name>A0A9Q0R8J9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8J9"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="250" mass="29565" checksum="EC50E8E59E4AA73C" modified="2023-09-13" version="1">MVDIIHSGWLQKRGERNSALKTRWFILRTSGDIEYRKKPNTSILGIIKFSLIISTFPVNEKTKKIKEKFVGRSFKIMYPKREYFLVAENATIRDRWVYLINDFIYRQNKKKISQDKEDLTEKIQKISSKIKKDQVIEDLKESHDTLLSSALSKGVNLVEEPDSIFSKDEYIQKCHQIKLLQEVNQSLRKKIQNFSLENDFENNNQTFSDSKPKQENLINLIDIFSNLRDLLDELDISYPSEITYIFEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R999</accession>
    <name>A0A9Q0R999_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytochrome-interacting ankyrin-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R999"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="216" mass="25037" checksum="5AB480D7225E587A" modified="2023-09-13" version="1">MKQNQNYQIKLNRKLFSACQENSIENVKLAIENGSDVNFKSDKGKSPLHFACQNQKSNSFEIIKYLISKKASINVKTKKGQETPLHLACQFQKNKNSIEIIKYLIENGADVNVRNKENDSPLHLACQFQKNQKAFEMIKYLIENKAYVNARNANNKTPLHLVCQFQNQPNSIEIVKYLIEKEADVNVKSHPLIQTPLHYVFQYQKIKKMNLKLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9E7</accession>
    <name>A0A9Q0R9E7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9E7"/>
    <dbReference type="OrthoDB" id="10660840at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42858" checksum="E29D52F288D60010" modified="2023-09-13" version="1">MGNKEFSLQIPKKKLKRYMKSFNESKEPMIIVDNLTKIDQVNKAFLDLTGLVSETQIVGEQISLISAKEQPHLNLATDMAVLLVLKKVLQSETGTYNTSWLFGKSRSGNNIWVSVWITLLYLAGKPAAQLIIRESENPIKADEQEKLKQEMAPNQLKLDTSSDTGVDVDSDSRSQKSQGAGDQTRAVRTSSLSHSRSVEQTPNQVVLEEQIQKIQNLVKNMKNEKLEEKVSNNLNQISSSIQDAIKHKDDQINKLNERLQQERKEHRKKYEKLESHLQRRLGGMETEKSVKQSILEENLSIKRKLKQLISIIQKQNTITDELYSLIDMSQNTNPQDESFDSFNESHGNEFTSPEDLDSTSKEDDDPKKDDNSKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9G0</accession>
    <name>A0A9Q0R9G0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9G0"/>
    <dbReference type="OMA" id="PRIEMNE"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF370">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="598"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="813"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="79"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="241"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="407"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1048" mass="125241" checksum="ADF1F3E1C4CCF792" modified="2023-09-13" version="1">MIDFSKNSHHQLVEIANKLKQENDRNTRKITLLEDNLKKNETLYSQQRWFYRNKIKEMIEKMSQIEKYKDKYEVISSQKQYSTKKINQLEEKIQKMEENEKKIESEIFSSFKERVNAIVKDRDDLYSQLSKLQNQIEEKDLEIHKNKQLFNDLIEEINEKESLIKEREKNVQEFFQKTKLEEETLQQKYEQIKQELEAEKKDRQNEKEMVKQEDESIRNKIILLIQQRNALNKTNQGIIFFVILQEKAEFEKNELQKQLEKQNQAKFVQKYGELIYENEDLRKDVALLSQEKTTLQIENNKNEKQIKQLKKEIEELKKENQQISKEKKEYYKVYMEQQSKMKWLEMENQEKQQLILDNKSTHNLIKHLQSNLYETRTEKEQYVIEKEDILRQNEELHKMVTFKENQILQMISEKSILEEQVRQLIKKNQDLEIAHLQISKSNLPVNEQPLENKQEISKNLEEKLTDKINKKRIKNHVLQKGLANATEKLTETQKENSRIREESIKLKAEIELLKFEKNQLKYEIEDEKQRGLNQIGKYESTINVLKKLNPVEPNFTSTNNDEMVQILKEFLDTKGGNLDTKILELEDPNQLIFERQEQKISVRYASFDMLIELLINEHNQDPEYLFTFLMVIRKFADQIKALENLFILFKKMTHEELKKMGKQKKTKMEKRNEKKKIQKNNSAQNEVNEEDFPRIEMNENKRDKNEKKEKTDFLFEQKRIVTLIWLWVENYSLDFSKYPKVSEIVFKFLEFIEHNSKHEAILLLSSKIKLRLNNEIKGINVSEERSPVLETKQAPEPFIPRKITLDSGIQAIKPIEAARQITIIEMKMFQKIQIHELCGQAWSSKEREKRAPNVVSMIQKFNDFSFWISHQIIKNNSTKTRASYIKTFIEIGAEFEKLNNFNSLMEIIGALHNASVFRLKKSWDKLSPEDKKTFEKLTAIMGSQNSYKNFREEIQKREKEPLIPYIGVFLTDLTFIEEGNPDQINGLINFSKQIKLSRVISKIQSFQQKSYNLIPVESLQNYFMNAVCPLSEHQLYQLSLENEPRESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9R7</accession>
    <name>A0A9Q0R9R7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle transport v-snare 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_01961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9R7"/>
    <dbReference type="OMA" id="MEYEAND"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5070979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="222" mass="25743" checksum="5C0E7BF759408865" modified="2023-09-13" version="1">MDMIENYEEEFLSLAKTIQEKNTKIPTLSGDERRQNIRSAQKELEEAFDMLQQMETEARSLTQENRNEANKKIQKLQDKYNNLQKDLKNAIASFSYQEDRDSLFSGRPDLQVTSQDQRKTLLEANEKLDRTTGILEDTQRVAFETEELGTQVLGDLHNQRKVLENSRSNLKTADVSVDKSHRLLSIMGRRAIVNKIIFVIIILVLLAIIIVIIYFTQIKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB81</accession>
    <name>A0A9Q0RB81_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB81"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5072449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="116" mass="14223" checksum="B5F63C874EF3A9E9" modified="2023-09-13" version="1">MIMELDNIIIEYYQYSEIFVQNQPTLEIEIELEIEIELEIEIELEIEIEIEIEIEIEIEIEIEIEIEIEIEIELELEIEIEIEIEIEIEIELEIRNRNKTEKNRNRIKLELELELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBR0</accession>
    <name>A0A9Q0RBR0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBR0"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="33"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="308" mass="36303" checksum="2A9308E4F3BB64E8" modified="2023-09-13" version="1">MQQVIKKIKKDNLKGRAKRVMKKKEPQIVEVVKSAMFVSGNKTSATIRQTLLDLYMLKKPHAIHLSRKHDIHPFDDEVPLEKYSYTYECSWFVFGSNTKRRPNNLIFGRLFDYHVIEMMEFQVEDYKSISEFEGQKCQNESKPCLIFNGEEFEHKFEYQKFRNMMIDLYRGKVVSSLNLAAIDKIFSFTIINNKIYFKVYVSQLKRTGTKFPRIELVEMGPSMILTLRRTKFATEDTMKLATQVHKSLKQKKKKNVSQSNFGDIVGQIHLDQQNLSSIVTKRPKALRRTKRKTQEKPNDNELEKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBT9</accession>
    <name>A0A9Q0RBT9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBT9"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="163" mass="18592" checksum="CF4CF8F0A9142780" modified="2023-09-13" version="1">MNEIIFFGRNEEPKLFKNEPEKIKKPIQFKFENENENENENGKQIKQIASGFYGTIFLFKNGKAIEYLKDSKQNPKKIQIEENIQKVTIGAQNEAILTLEGNVFAKGIDINSKKPKEFINISSLIEDTNDRIIQDIVSGAHSIYLLTSNQNAYGIGSNEYCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCJ0</accession>
    <name>A0A9Q0RCJ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCJ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="6">
        <location>
            <begin position="410"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="71554" checksum="BCF44BC096CD0947" modified="2023-09-13" version="1">MDNNNNNQIENANQNQNQIENQNENQIENANQNENENEMKNLEKKVTKNLIKDYSNLLKENSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNKFLKERNEIDKIFLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEFIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNERLKGKKEKEKEKKRLFHSFFSLFDKDSIPKQDFYKLKQFDFFLPNSFLVDIQNKVIQDNQKENQIQKEEIDNKEKKIPKKMIRANKKQEKKIQRRDKKIQRRDKKISSFKSENQKQKQEIEKQKKDIQNLKSENEKKDNILKQKDEEIQNLKLSIEKSNQNEKKLLNMFPDSIIQEIEYVLKLQEWINDNEFFSKMKKGFSAKKDGFTGNKWHSICDNKGKTLIIIKTTDNYIFGGFTQVGFKSGSNRYIKDSNAFIFSLKNPKNDLPQKFEIQENREDYAIRYVSSNGPRFGDHRNQYCTDILISSDLHKGHTDFGATYKLPNGLKHDTNEAKSYLAGSYSDWTVDEIETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCP6</accession>
    <name>A0A9Q0RCP6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCP6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="622" mass="75021" checksum="12503206E623EA20" modified="2023-09-13" version="1">MDNNNNNNQIENANQNENENEMKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNEFLRRKNDIDKIFLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFFFQNRNLKLNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLDNWIKKRNERLKGKKYEHKMNAKKRLFHSFFSLFDKDSISKKDFDKLKQFDIFLPNSFLINFERTIFEIKDKEKEKKIKENQTKIKKKDKKIEEKEKKIKRRDKRIKSFQSETQNLKSENQDLKLENEKNKKENKEIQEKLKKENKKKDKILKQKDKEIQNLKLSFEKEIEKENQKEESNQNQNQNQNQNQNQNQNQKEESNQKQNQNKLLKIFSDSEIIKDIEYVKKLKEWINDNDFFSKMKKGYSAKRDGFNCKNWHYICNNKGKALVIIKTKDNFIFGGFTQVGFTNDKSKWREEDRNDNWGFIPDSNAFIFSLRNDKEDRNPAKFTIKQGKEEYAIYYHLNDGPTFGSDIHLKFDLQSGRSNFGNSYNLPNGIKYYTNEAQSYLAGSFDKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCU8</accession>
    <name>A0A9Q0RCU8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCU8"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000009">
        <property type="entry name" value="Ubiquitin-60S ribosomal protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="156" mass="17775" checksum="B294DDB2FDB34BC8" modified="2023-09-13" version="1">MNFQIFVKTLTGRTITLDVDPNDSIENIKSKIQEKEGISPEQQRLIFAGKQLEDSRTLNDYSIQKDSTIHLVLRLRGGNFQIFVKTLTGRTITLDVDSNDSIENIKSKIQEKEGISPEQQRLIFAGKQLEDSRTLNDYSIQKESTIHLVLRLRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCX4</accession>
    <name>A0A9Q0RCX4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">X-ray repair cross-complementing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_06758</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCX4"/>
    <dbReference type="OMA" id="YKLECQI"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="12">
        <location>
            <begin position="302"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="564" mass="66002" checksum="2F6BB47A33A96170" modified="2023-09-13" version="1">MSFFEGFQFENENENENENEFSLFRDCILFLIDGSFQMLNSSTSNIEIALKCFLFTLTDKIATNPSDMTALCFFNSKNEKNLNGFSNIYVLYDFQKPSIKRIKEVINFTSKNTNEQYSLQIGSSDDNSKTTFEQVLIACSTLFSSNQDANKADYKRIFIFTNNDSPNNFDNQLNEKSYEIGTKLMNSGIVFELFALDQNFQLENFYENFLFPKNDLNLQTRNAFVKLNENYVEDLYAQVRRKEHQIKSIANIPMKLPGNLEISIKVYPVIKKNPKKNLVWLNPNNLNQQLEKRTVWVSKTTDQIHRQSQIGQYCEYDGTQIPLTNDELSLLKYYSQPCLDIFGFKSKNYLKFLYNISTSFLVYPNEYLQEGSSTLLSTLYQKMIEKNVIAIEKKDQNDDLILQKGFGLIPLPYSDDIRKIPLKPLNYPNQIQNSIQNSIDFIQKFQINFDSWDFEDPALQQFYLKLHQLALSNHFSILNSNSNSNSNSNSNEIIDRIKPDSERIGKYSKLFSNFDQSINECVNKDNKEEKEKKKKKRKEKEKEKDKKKGKEKKKKSKKNKRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCX7</accession>
    <name>A0A9Q0RCX7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein diaphanous</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCX7"/>
    <dbReference type="OMA" id="QAWICER"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="806"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="568"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="655"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="747"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1227" mass="140599" checksum="ABAD05330B7F5461" modified="2023-09-13" version="1">MKSSTVVDDEQVLGLQVQVESLIKERNELEKRVNELENKMGFNDDEGTKVIIVELNERIIGLNAQIEEQRQTITSLTEDIETYQQTILLLQEEYENAQEQLREHLEEDDEVEKKPQRDSKNIRELKEQLDKANRELEETKQELKATQELLDEEITQPKGKVTDGDTMGDSDKDEEIFLLKQQIEQLSNDCAAFQRVLSNTRTKYEEQIDELTEQLQLYQKGDEKVSSIWQKRYQLLDNEKNEEIRKMEENMVLLKEEYSSEIKELNSLVANLQNDSDNYQRTISIVKETYQNQISELTQRLESKAQITSEYRELKSVEAEKETLEKMLSDSKEKYQEEKLINDQTVSNLRQIVRDMEDDAKNQQQALDLLHERVQELEDDATAYQRALMSMKLGYEEQLQQAQEELESLRENAQMSDQKDSSQIAVKSDSKEELANLRRQNNMLISKTKDMEAYERMMSSLRKEVEDLKKESQKHAARADEFTEKYAKVKEERAKSEEIYQKDITKLKAQLSSLQLSNEERTETTGPQNGARQPDTKRFINLENKVRMLSTELANERSLAKLTQNTLQKRYESQVEVLRSKLQTAEAQMQEISQEMLRERREMEEQMRKMMESSRMLSGKKQDRRENLREIQKGTPVKQGELSDEMGAQEISLMRQGYEQRIKSLNTQLATYMDLEKKHKEEIEELRRSYEAKISAISRYVTPTETPSLETPQDDSDSTQTPLKTSGKYSRPLPRGRRTGGGFTAQRRQFEDTIRKLETEVAALKRKLAEAKPETEDSQQALALELFSGVGNTQFVPRVFEKRKEAKPNPDPSVPMKNLNWSRISNARVEKTIWNNLSDQEVQINKSALEAAFRSTSSGETTSTKSGQTTTSAQTSRSKSKSQTVTILSPKRSEAIALMLSGLQISFLGIKEAVLSLDDAALTTDQLILLRQNAPKVSEIEALEEFQHLSPTRFGKAEQFFLQIRHIPRFSARIQAWICERTFADKIQNICSLADDVIAACKEIQESEKFSAVLSTILAVGNYMNGGTHKGGAYGFRVSTLVKLNQIRGTGSFPTLLHFVVNLVKTNQPQNVSFSEQIPHISGAAKASGKFISTEVNEMTKDLKIVGLEIENCAGESTGEVFKTRMLKFFANASKQHREMVEKVKLMEDTFNSTAVFFGEEIENSDPAKFFTAINIFISAFDRIAAGKSQEVKPRSQTKFFKKQGNVGVVDGLINSLKSGRISKQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD39</accession>
    <name>A0A9Q0RD39_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1603"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1869"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1603"/>
            <end position="1614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1957" mass="229426" checksum="322DBC90D984FE56" modified="2023-09-13" version="1">MVISGFVIPETNSFCRATIKETLSQIMKSNPDWISFLLDIIDNIQSLISVSSFHKFLLYPFNKWRPKISDFLILKKWILRGEKNHICMFAREIISKINFGFADDEEDEDEFNQFNQFNQFTNTNTNTNIDSNTNIDSNININSNTNINSNSNIDPDLPQANIHEIFGTKKKTLFVHPYLHRLCLLILTEFWITVLVSKKSKNQILLSETNTFTKFCWDTAYSLNLYTKFGESRLPKFDISGKEIDPQITFLKQYISKKTKLDAFIANTILLTTNAFGLYSSSVRNSPTVFSRELIKAFLERDLIPKFSITLYHIIPEFVQMNVVQQTNSQQLNIKNIKNRNTNKKQAAINNKSFANKPEYNTKLITQKLRRKSVKRASFYFYQCLSPLLSFFFTEDSFMKALELFDFVSYDSDNTLKEEVDEVFENRSTTKPNPNDPNTLHPLSIFGNIASIMIYHREKEKKVFESQVVEQSKGIPSDILKIRYENSESPNLIDIFTKNYKIKQHFLREEVFEHPSLLPFTKCSQQFCEKLATEFSFFLFETLIFETEMERELTQAIGEIITRSDKPIKSMKQDVFIMQHLNYVYWWSFFAQHNYSILSPLIWQMIFKIYFSFLMYTNKSSSFPQKELLFGSKLFELVDFPKESLNQFLSQTKNYFSNSDTAIIFSTMQRWLATDIEQLYITAEDHFLRNVDFYDFGKLKSLFLPNSKLWMELVDRNGVFMRIKRIAQKNFPHYEDDNTTTIFTSNNSEISDFNYDSTQNIDMDDNNNNNNKNNNSNNNNNESNKTKNSYDYDSISFENIQKESDREIFSFLHTKTKDNAKLSKSKQKTRQKYIPITKTNSDFETIDHKKKTVCQNTKQLNYYDFVSTPYLFEKEIVFSKSSEIDFQKNANKMKEYLKIIELSSKQFQYYSSIHKQADEIFINLLPRIFTKAAKKEISIQDTSSNTTEKPISLVPNFQEYPREMVCAVLISNRKKISKFTNRKTNPNNKIASNIIAAMINITSYIDRIIYAYKKQQKQELFIKDGANKSNQDLAVLDLQHRSKIDFEEMGLKWFKLLLRFNQDECQEDPLFDILLHQTIPKLFHFFVKKTQKITKYIIGNPSSFPFLVKEMDPAKKDENLMMLYQVVVESFTQESSPANAKALDTLFIHFNFQKWIETPQREKSFYLELAKNQISIFTSDLEEKFPGLFFHISRNIQVLMRTIYRSNFPDILKFILDKTIENKVNLQVWTFLNEILGVCVYAGNADQIADILHNFLDSQTKTAQIPNELYLSLSRYLPYLVVFLNKILYHHNTSLRNYHQDLFVLTFDFIWKIFEPFFIAANHEKIHINNYNFNLNFAHEIFNNEKIILKIFSQYILALQKQDPSAMKNFASHFLDLFNEDFSFSSDVCSVLVSDLPWYKVQIEEDLSKKFLAIHQFLSFDFLTSIVPKLDHSILVSGDSSSQKAVEENILLFIIYLSIRKERKRISNNSKLKWVEFIISILGKTKSITISHPVFDSICSSIFNTFENIELKKLPYTSLTPLDSVYTFNQKNTPFPFSIIQFIGQIKNPENFNHLCSYISTIITAISISIQRIEYENSLKSTKYGLNKKFLNKNFHQSSFEGLNPKQLNDSNLLSPKKGNQNNNNNNNNSVICNTDLGINDVSYLISHLFQNLEFWNQAISSDKSKKSNILTQISSLFDILNADLLQKMLNLTFQFIKKTETQNIVFFACSLTNEITESQVTFAILFEFYISEYLVRPQSSFSKLLIEMKESKHLSLLDNPSLEDSFLITGSVLSLCSIFLIKFQENSQKQSQKNAQFFIPFIDEIIQWIYSIKLENSHKIKVIFFVEIWLVLISDILKTNPGIFAQKQKHFAYDLVRTFKEISQIEDLNENENENQNLNQSEIQNENQIQIQIQNRKSNSKEKENEKENENYLHFPQLKNSNNEIILFSKILSQFMEQSLNITEMNSKDIFPFFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REN5</accession>
    <name>A0A9Q0REN5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_05223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="904"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1270"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="170"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5077966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1383" mass="162418" checksum="49693C68DDA8A7F4" modified="2023-09-13" version="1">MSHNFPKNLLSLLKLVKNISIEEVKKLNLKDTKENQVEISLQILKNWINKYLSKTTNKQHINDLSADIQKLEIFSSVISLLIPDIDLSAISQQNDYQSSIKFIFSKIKESSYLSYTCDPQTFINGNENDIIKFIASLFIWHKSNFFDSESESESGDEDQNLQENLQENLQENLTENLTENLTENENQNENQNEKENQIENQIENQIENQIENQIEKENQIENQNENQIQNENQNENQNEKENQIENQNEKGNQIENQNEYQIENQIQNQIQNENQIENQNEYQNENNQIENQNQIENQNQNQNQNQNENENQNQNENLIGNENLIINQVKIPNNYFSDLEFLFNKGYFDDLENISQNLEIDNIIQRNLDNNLENKKISLEDEKNIEKSVNEILESISKAKKFIENQKKELEKKIQEISQHKSKPDSNLFIITNKDKDEDEDEDEIQAHPILQNSIDSEETQMEMKGNEQNQALGKKSYLNSQELLRKKSLSQNIAQSPKRVTFSLDPNEEYFDSKLIKDIKKDPNDTNQTVENENMSQINKRKQEINEKNWDEYFQNKKENEYLKQEISHKKQAIEVLKSQIKGLKELEEYKELKGEKSSKPFLFKSSNEDFANKFLVFEEEIIRSLQPVRFDLKKFLRDITSIPKASPSLLEILNAKIYDENIEKISTETLGIIEKFIEYLILILQEINISFPVTSGKRFIFGLRNLDELSADPSEIYLMIKKLFEENSIILSKKDIVIANSLCDLFVFVVTFKQNLTQKLSTFFEDNDLSFQNYELDSIPDLIYYHLNYVVDFSPNFKDLIDLFIESFNGINIPNSNEKLTEIINSSRREALGKTIHCISKRLLKENYQNKLTQEFAQHKETPKQSIMDEMEQANEYLKEYLNPLDLQYILFLIDVNYCGDEIDSLSPSLLNLFDSFGLSIHLLKLAISREIKQTQSIQYFFRSATFCSKLISDFSFSVGINYLISTLKPVVMEMSQVKTSFEVDSYLTDDCESGQKNLSEYFFKITNSIFESVPNIPFYFREIANHIKTEMLKRFPEDALLGIGSYILHRFFCPAIVSPKLYNIVDYNLNEQISRGLLLISSSLANLASGKLFGVNREYMNFMNKNIEKQHEKLNQFFESVSFVEDQETQYISIDNNRFIVYISSIYRKSNQNNQISKNEDQKEKFAIFLDLLIPNEKKPQTSFNKKKIFQMETVYQNLEQIVFDFQESNSILSKLNEKLKEIQQIKSSPSHLSNLLSEPQKKIRKKPTLFCNQNLISKWAALWEQKPELEGWLSSFAIKNQKKIKRAKRYLVFKKNIIAVFESNVENSVPLHVIIIDNSTKINQEKSSKFHKKKRLSIFRKGEEEIECWLTFDSDETYQNWFSILHRARKKFTKSNQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REP2</accession>
    <name>A0A9Q0REP2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REP2"/>
    <dbReference type="OMA" id="XITELQN"/>
    <dbReference type="OrthoDB" id="10067969at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053236">
        <property type="entry name" value="Cornifin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13884">
        <property type="entry name" value="DUF853 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13884:SF9">
        <property type="entry name" value="PROTEIN CBG13449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="652" mass="78617" checksum="117219225B976740" modified="2023-09-13" version="1">MKDLFFEKAYSSERVTKNTQECTQILMNLGDAKRNLLIQLKGKLEFIGGLKDINRKPDLAHPFPCSLTHQPFPLLTYLLALSLTHPLRQISEIKELKNKIIKESNNQRVKESKNRRIKEVKELKNKIIKESKSQRIKESKSKRIEESNNQRVKESKSQRSKNQRIKESKNQRVKESKSKRIERIKELIKESKSKRIKESKKLKSQRIKESKSQRIEESNNQRVKESKSQRIKESKNQRIKIKNNQRVKESKNQRIKESKNQRIKESKNQRIKESKNQRIKESKNQRIKESKSKRIKESNNQRVKESKNQRIKRIKESKESKSQKNQKNQKNQRIKESKESKNQRIKESKNQRIKESKNQRIKESKSQRIKESKNQRVKNQRIKESKNQRSQRIEESKNQRIKESKSQRVKESKNQRIKESKNQRIKESKNQRIKESKKSKNQRIKESKESNNQRIKESKNQRIKESKESKNQRVKESKNQRVKESKNQRIKESKNQRIKELKNKRIKESKNQRIKESKESKNQRVKESKSKRIKRIKESKNQRVKESKSKRIKESKNQRVKEIKESKNQRIKESKNQRIKESKNQRIKELKSQRIKEPKSKRIKESKNQRIKESKNQRIKESKNKRIKESKNQRIKESKSKRVKGSKSQRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFK5</accession>
    <name>A0A9Q0RFK5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFK5"/>
    <dbReference type="OrthoDB" id="8187571at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="220" mass="25458" checksum="CCFF24E2530E1058" modified="2023-09-13" version="1">MSSSSSPSDFDDISETEKFHLRCEKLYQNYRPENIWNINESNLQYDYTRETTLSPRGKKQVLARNKINQKQSCTLIGCIAGDGNKLPLGFIFKEGKYAKKWMREDTPCVLIVDNFKTHINSTFIEFAKKKEVLIELIPQNMTGQLRPLDKLIFRQFKGKYKEEITGIINKLDCAQTKRTKVSEGCIKIWNSILGLTITNSFRLTGIIKPSDEFICFANFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFL1</accession>
    <name>A0A9Q0RFL1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of g protein signaling</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000043">
        <property type="protein sequence ID" value="KAJ5079016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFL1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="55"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="178" mass="21282" checksum="1BBFE9300BBE0AA1" modified="2023-09-13" version="1">MKKKKTKTKFKTKIKRKRKRKNKIQKEKENVQKDSPHSLPERTKIQKVNPKRSNQLLFWFHVHNYQQFCLLWEDSIAKIHAEYIINNFLKEDSQNTINIPQEIQQNILLQLNQMGENPVATLFDEALKIVHSSLISDKILHYRFLRSLHYKELLSEINEYKGLSSQNKKIITIITIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFY4</accession>
    <name>A0A9Q0RFY4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFY4"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="7">
        <location>
            <begin position="431"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="656" mass="74826" checksum="DD737F24798B6537" modified="2023-09-13" version="1">MISSLSLNTLNKPLNTKIAYFHLFRKYLPNLIDNQNQNSEKSKSKSKEEEKKYKILTRKNILLSAAIGTGLAISTYTIFPQEKEIGEIGIQSIISRIENTLKIKDFQQVFELLKELNSKITTKIFSSNLAEINLLLITRYLFSWTKNIDYSLNTTSKFQFFTKENNLNTKNTQKLKLRILGEIFAILSLIINQDEEFKILDIIKKNLPFDTIFRLSLHKKINENFFDSKRTIDSEQTTFDFDSQIMGLVQSLIQEIGKSQEEKKAKDNLINVLINFNNETQFSLFHNSIIQPNYQKQAKFLLKALLQIDFTPQIFKIFMANSGFQILHFIAKLNPSNKDSQKSIPNIVSKLIESDASLHLDSTIYTKIQEELLSSGLLKYFCIWIKNDDIYISSNITRVLLNLVSRKQTYLTGINVVHPQFPIIDQEGIDIVFVHGLKGNFVKTWRGWFQSGNFWIQSLLPKDINKSARIVSVSVKTFLGGWGSEGGSLQDMSLILLQNLQKAGIGKNRPVIFVSHSLGGLVVKELVVSAQTKYPYLFRNIRGCVFYSTPHFGMSISSQSKYFELLFGPNSSLNILTDKNSLISLNKKFGTLKIPTLSFAESKSIIPGIIVVSPQSANPGFGKFILTKESHRTISKHKSRDDPIYQELITFINENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG00</accession>
    <name>A0A9Q0RG00_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000052">
        <property type="protein sequence ID" value="KAJ5078639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG00"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="129" mass="15582" checksum="64E15B9D88F45289" modified="2023-09-13" version="1">MEKDQKKLKNYKKLFIEFREIPDSFFDHIFDFGSLDDESEKLYLNEMIKQKFRNNWGFIQDEINESIELYKHLLSKSHQFAKLKSFDTKSSISLRDAARTLKIWEYLLNDDLTLNLFIDPEEFRAMEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGV0</accession>
    <name>A0A9Q0RGV0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBIQUITIN-60S ribosomal protein L40-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGV0"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="87" mass="10309" checksum="F082B4D41171130D" modified="2023-09-13" version="1">MQIEVKDFTGIMGYFEMDSNDSIKKLKTKIKKQEKIPINEQRIFHLGKELENERTFNDYEIDQRDTLEFVAKLPEKSHCSCCSCFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHD5</accession>
    <name>A0A9Q0RHD5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000015">
        <property type="protein sequence ID" value="KAJ5080049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHD5"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="155" mass="18535" checksum="1DDA2141D2473773" modified="2023-09-13" version="1">MIKLRKLIKLISSGYSLSKKDQTNQIWIQIRMSLIPLIEIIITIPLTIRRIREIINPSVSQILSLDIISSLLFSSQGFWDFWIFIIFDPEIRSKLKNCCSYSYSKYYQQNSFDLDFFDSKNDKDNDNDKDIYLIENLEEKKKEKNEKNEKTKNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5A6</accession>
    <name>A0A9Q0L5A6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000145">
        <property type="protein sequence ID" value="KAJ5066366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5A6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="76" mass="8683" checksum="D251DA454262FB3D" modified="2023-09-13" version="1">MRSYRVLCRFSSKCSNVFFNFTSPNAPAFGLSATLRRGGSVDDLGLYTKTTNVAFLIYFFSLLFLYCSILIRIINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5F4</accession>
    <name>A0A9Q0L5F4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein rad57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5F4"/>
    <dbReference type="OMA" id="PCLGLQW"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="1">
        <location>
            <begin position="92"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="364" mass="41503" checksum="298BBA3672DBB88C" modified="2023-09-13" version="1">MNSNSLLNPLNFEKFTLFNFLDGKISKEIIDEFESKGFTPSQILLQSNFGLFEDDKIKLKKEDIQKLLYTLSINICGIPKTLSEIIDSENEKKILFTTNDNIIDKAIGGGFSIDFGLCEIAGEAGTGKTQFCLHLLSCLPKNCFAFYVSTEHSTQIERLSEIAKENLEENNQNELTDLFNRIYVNNEIHKESQLNELIFHQIPNLCDRVKLVIIDSIASIFRSQTDIIKRSSSLLKISNFCKYLSKQFGVVFIFVNQVTSIIQSETNPFLIRIPNTGIMFSPPNQNSPFKPSLGLVWSNCINSRIMLYKTSKNYSSNENLINQKNEEQINENFERIRKLEIVFSPILSNNSCNFLITKKGLKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L641</accession>
    <name>A0A9Q0L641_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000143">
        <property type="protein sequence ID" value="KAJ5066424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L641"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="570"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="96655" checksum="ED29536862C94223" modified="2023-09-13" version="1">MSTIGFDFGTEKSVVAIAQSGGVDVLQNEFSERETLSIIHFESHKKTIGTNAEKSRISNHENILILMKRMLGKKIDEEIIKKLIESTKYSNIIEGENKRIEYQISYGDSTKILSAEQATAIMLSKLQEIAQFDHQTKETVLSYPIYFTDKQRCALIDSAKISGINLVGMISEPLAISIAYGFPKRNFPPINQKPYRVCFVDFGASHITSTITEFWQGKMQIISTAFDNNIGGYSIDNIIYKKVSEMLFNQFAIDVNNLKHKMQVRLLFSCISLKKKFSRNQKEAVIFGNFTENQEVSLTFKFEDFEQIISSEIEKAISVVEKSIILSKLEKEEIDSIEIVGGSSRILLFKKKLTQFFGKSLSTTMHTTECVARGCAYHAVLKSSRFGTKPFEYSDIYPFGVSLSWTSDAEDIHSIFTLNPISAFTLDLVQPFQAIPVVYQVHLVRNLNFILQIQYSSHQIKPFVLEEHLQEDFISQYLFSLQKASVYQSNESLSSPKIIQIIPHFYKQTEQKNVIFPNYFSQNEKDYKQIEMKENHIQENEMNLQKNNRSLQKISNFIEKDPRLTILNGNENQNENQIKIKNQNQNENQNLNENKNQYEYLNQYFNQYQVSKLEEIHPLKNENGMKQEQLQNLIQEEMEMEKNHSVVLETENARNELEKYAYTLRKGFEYQWTTYITQQHVNSVLPHITDLIDWIYSEGYNETKQEYQKRLQQLHSFGDPIENRKLQFENISEGFQSFSILLDSHLQNAIQQNQNFSISHDDFKLIQDKTSEMRQWIEAKSKEFSVFPMTEDPPFDSLIILQKQNEYEKFCQNILNSEQQKTTTTTTTTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6H5</accession>
    <name>A0A9Q0L6H5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Atpase asna1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000131">
        <property type="protein sequence ID" value="KAJ5067247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6H5"/>
    <dbReference type="OMA" id="MDAPYEF"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="2">
        <location>
            <begin position="310"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="364" mass="41974" checksum="72BDD690FA6E4459" modified="2023-09-13" version="1">MESEIKINKTTLSNLLQRKSLQWIMFGGKGGVGKTTISCSFAIELSKFRESVLIISTDPAHNLSDAFDQKITSEPTKINGFTNLYAMETNNSFELDEKDDLEKKLDNSQSNPTFNFFQNATKSFPGIDEMMNFFNFMKLVSDMEFSVVVFDTAPTGHTLKLLSLPEFLNKPFSKIFDLKSTALKLATKLMPDFLSESDEPEEEQMDILNKSLDQVTAQLRDSEKTTFINVCIAEFLSLYETERMVQELFKFGINTNNLVVNQLIIPEKSEKILEILKQDQQTQEEIANGIQTKLKINSQNDSENLRFLKNCPLCDSRSRLQKKYLDDIDILYEDFYVTKMPLFPFEIRGIERLKRFSQLLFDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6V3</accession>
    <name>A0A9Q0L6V3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6V3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040293589" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13088" checksum="53E93DFA494D59FE" modified="2023-09-13" version="1">MNFKIFVLFALLAFAFCDSFKTTTNTTLNVYNDNACTNLEGALNMVANQCLNLTGDSLSSSSQGSLESTNATTVYYYQTTSDCSGNAEGIVMQAGKCYPISSDAPIQSVVLGLLMILSLVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L756</accession>
    <name>A0A9Q0L756_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L756"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="514" mass="59798" checksum="33BFE00799E06023" modified="2023-09-13" version="1">MNNIWIVGKYHPNLLKNQPEKVTRPMRITFENENENENEKQIKQISSSSYSTIFLFENGKAIEYLNEKQKPQKIQIEENIQKVTVGFGNEAILTIEGNVFAKGKDIISKNPKEFINISLLIEDTNDRKIEDIVCGRSSIYLLTSNRNAYGIGSNDHGQLGFDYETLEKTEKPILMMKNVSKIFSGNSSKYVFLLNSNQELFGCGDNKYGQLGLGESITEQKIKQLTKIEDIPKGEIIDIQCGCYHSIIKLYSCGNSQFNAQYGYRDSKKFTEIKSSLFENDQIRVFSVGTYHTLILTYNGKMIGFGVHYFPRLPTDTYSYFDYNQIAELEPPKFIFDISNYQISCGDENSFLYYSPFLSNLEEDLIKLFRRKEFCNLSFKTENGEIIEAHKLILKYRLKDQNQIEIEKLQKIISNKSIQESNQIFEMIYSNNSKINPKLYSEIKEIINSNESIEETMKRIYLNENDFIIERKEKQYKFPKLILIMRSELYRGMFLAVTDDTSSQNLKLELIIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L758</accession>
    <name>A0A9Q0L758_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L758"/>
    <dbReference type="OMA" id="QRANITM"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="37"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="138" mass="16565" checksum="9C281DB12655269D" modified="2023-09-13" version="1">MLSNFNENTKIQPKTITNVFDEENRIEKREEEILEHKRRKRVKTGLPPTSKRILLIWLFYNVENPYPTKEEKEELCQRANITMAQINNFFINSRRRILKPLLGDYHTKELAHQIKTRKRKKVPMDQIDFETSPVLSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7U8</accession>
    <name>A0A9Q0L7U8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor ap-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_13422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7U8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="193"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5066653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="304" mass="35483" checksum="3A61F8BFAEBD07F7" modified="2023-09-13" version="1">MFSTHSFKIPAESNNISKTINNNNNNEIFDLDYFDHFDTFGVEDFTDLFGNQSYGQNYQISDSKEQIFQETTDTTGNGQQTETLEKTETLEKTENAQLKEVLKQETKSKTKSRTKNKRKNKKRKSKSKSKSKSKSKSKNKKQKGKKSKCKRCKSNKCKLMNTIIQVTDPTNQIRTLDLSGKLTREELKLLSPKQKKLRRMLKNRKSAQRCRERIRDRITQLEVESEQMKNSQLQLEDEVKFYENANSLLKKEIEIMRRELFRRETSLAFTNQNPFYFPDADLIPISTNGFSAQISDSNSYGIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L954</accession>
    <name>A0A9Q0L954_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_12354</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L954"/>
    <dbReference type="OMA" id="LRLCPWF"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5068371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="217" mass="26235" checksum="16DF93DD5C17500D" modified="2023-09-13" version="1">MENLDKTQMEFMNDEYCIVVDLNDKPQRSETKIKCHQENILHRAFSVFIFNTKNELLLQKRSENKITFPNVWTNTCCSHPLYNQQELQEKNQEGVKRAAIRKLEHELGIHNEVKWEEIIFITRIYYEAKFDDKWGEHEIDYILLIHKDVNVQINYNEVSEIKYVNEDELKKIIEEGNVSPWFKLISEKFLFDLWEKLKEKDYDFNKGNDFSKIIHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L979</accession>
    <name>A0A9Q0L979_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000119">
        <property type="protein sequence ID" value="KAJ5068170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L979"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="236"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="349"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="522"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="627" mass="73118" checksum="0FABDC45F87B31F9" modified="2023-09-13" version="1">MNPNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNEFLFFGLNDFPKLTTNEPEKIKKPIQFKFENENENENENKKQIKQISSGSFSTIFLFENGKAIQYLKGNQNTQKIQIKNIQKVSGIYHIEAILTKEGNVFAKGNDVNPKNPHQLINISSLIEDKNDRIIQDIVSGNTSVYLLTSNQNVYGIGSNEYGQLGLDSKMFGYKQKPILMMKNVSKIFSGNFSEYVFLLDSNQELFGCGWNSYGQLGLGESRKGKIQKLTKIQNIPKGKIIDIQCSDAHSIMMIANDVGKRKLYSCGNYYSNGLGTEKYEEDTYEFTEIKSSLFENDYIIDFSVGFNHTLILTYNSKLIGFGNNEFGQLGTEDIEYDQLTPIQIELPKLRFNENISNYHLSCGDSDSFLYYSPFLSSFFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLKDENQIEKLQEIISNKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVKDYSELSNKPFQILEYWIYSNQIKDGIQITEEIIDEIQIGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9U9</accession>
    <name>A0A9Q0L9U9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenosine/guanosine diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5068972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9U9"/>
    <dbReference type="OMA" id="WTCRIKE"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24003">
        <property type="entry name" value="ASKHA_NBD_GDA1_CD39_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="551" mass="62977" checksum="28A1077A174AB565" modified="2023-09-13" version="1">MINRTKITLLILFTLSISCILVTVFVKVHQKTIKEKTNYAIVIDAGSTGSRLHIFYWETPNGFDTPYIEEMETFNETEPGISDCLNNLTQIDFLIGNLLDAAIQFIPQENHQETPVFLKATAGMRLLSKQNQDIIIQKCQDVVSKYPFLYNPQEIQVISGEDEGLYGWISINYLAGNFLNYVENKVTYGSLDLGGASTQIAFIPKENQLLYNYSKSVHINSTDYILYSTSFLGYGITESNIDVIDYLISQNEYLVEDVIQSPCFPLGLNANFCRTNGDDCRTINGTGNFSQCSDIIKQAKFPNASCQYPHCSINGTFQPEVTDYYYATSVYYYVNEFFFGNSNNTSSIQDIQQQGIAYCNLTFSEIINKYGNDSDLLPFLEIYCFDSAYLTTLLHSGFGFQTSGQQTINKVDSINGISVSWTLGAIIAENQFFEYSTQSSSSRFVTKIPGIILVSFFSLFIVVLLILYCRLRSKSKKSSIYHFSDQDDVEDLHSSDDYKFSHIDKYKDEEIKEENLRLYDSQEIFNLIQFKSKELNNKIFFRFNFLIYNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA84</accession>
    <name>A0A9Q0LA84_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA84"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="159" mass="19258" checksum="A5F9D5414CE51F37" modified="2023-09-13" version="1">MDNNNNNNNQIENENQNENENEMKNLEKKVTKNLIKDYSNLLNGNSNSFKDFSIFVENEPNTFEIKVHKSILFSRSSFFNKFLRDRDQINKIFLRQFNKREMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAK7</accession>
    <name>A0A9Q0LAK7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAK7"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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    </dbReference>
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        <property type="entry name" value="GTPase activation domain, GAP"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="169"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="834"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="835"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="874" mass="101213" checksum="D1483DA981C235AA" modified="2023-09-13" version="1">MNEVPQLYIQIIRVHVQEPTLVYPNVFVTVKFQRHKLKTTPKQTLEPKWNESFLFFVKNNNSVIILKLWNRLNSKKEIRLGKVNIPLNSLTNEEPVEKSFDFLPLKKKNKDTPIGRIYVKLHYTYSKVRLYDTQREIQWRKSLPELIDLICGNNFEILNALTDVIQSGDIDKLTETLITILYPFGKAVSFIKNAIEREIANTSSPHQLFRTNSISTKAMSTLCMIICKDYLSKTLKIPIQEVLKIDKIFELDPVLIKPNDSIDENFRLIKTYISRFISSIVSSKKNMPLEIIDIASFLRQSVRKKFPENEMISVAGFIFLRLLSPAIINPQAYEVINDPPNQISRKNLIWIAKIIQIIANRTGFSVKDFLLLPLQEFHDLKLPLIEEFQKQVSLPLQKEYKPTLEKDPETILFSDIVNLINFLNQNLYKIETVLSPPETEDPNKTGEKGSSLFSFLSETDKVTQFAIVLNEFGIPPERAFHKFHTISNEVIQKRKAMKITEAKPGRLSSEETKDEELIGLLNNESVFSSEPRDPETVSEILAETLRELFYNTMSTKTELVINSKPNTNVVSKKSNANSGKGLFVYPFWNWIDLQKNSKYLEFTQVGIGELKLIDPQKIPNINRLGFWLNIYNILFVHSCVENQGPPQSAYQLKRFMSENKYKIGNCVYSLDDIFQGVLHGNHKNFSTNRYFKKKTDPLTGPAFYVFHRDSTEKELFRSAQFLIENYGQIKDTTQDPSVSLPTFFKYHRSDFGKKEEELIDFILSVLEITESSLYLKLKNLTHSLLNYEIKYKDIVFIQGKTELFDEKNQKLFQKIPLVHTQKLSQLIFSEKENIGNQNKNNNGNQNKNNNGNQNNNNNNGNQNESLQNENLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAU2</accession>
    <name>A0A9Q0LAU2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAU2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="313"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="46196" checksum="A65FBA4E99B2B938" modified="2023-09-13" version="1">MNDCLFFGLNQFPILIKNKPNKITKPIQFKFENENENENEKQIKQILSGNISIIFLFKNGKAIEYLNQNPEKIQIEENIQKVTIGSRNVAILTKEGNLFAKGKDINPNNPNEFINISSLIEDKNDRIIQDIVSGNSSIYLLTSNQNVYGIGLNYFGQLGFDFKTLKETKKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGSGNNFYFQLGLGESITEAIIQKLTKIQNIPKGKIIDIQTGFNFSIMLIENENENENPKRKFYSCGNYQFNGLGKNEDTYEFTEIKLSLFENDDNILDFSVGSYHTLMLTSNSKLIGFGGNSYGQLGTGDTEYQSFPIQIKLPKLRFNENISNYHISCGENNSFLYYSPFLSSFSNLEEDLIKLFRRKEFCDISFKTKKWRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBG6</accession>
    <name>A0A9Q0LBG6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myb-like protein x</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBG6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="32"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1104" mass="127954" checksum="A960F2AC719FEA08" modified="2023-09-13" version="1">MELPFDVRALLYRVAFHAEAKLLKTNPEDVNLTPIQTLQKWVNFHLKNKNQKEISNFNEDLKNCIALSFLLSEITTTDLDFVSVAKWPIESQRSQKFLDLLKQTDFTGPFCTETDIEKPNEAELVKLVSNLFLWSPAVKNKPTKKQAQKTTTTSTPNVFSSNVQKILSKTKTTSTMSILEKLKMNKQAAQNTSNKTTNMTTSVNTTSNAKTNPKPNPVLNSKSNDTNSVQNQQTVENQALPQKTVLNPFSKYRKNPVLSTSTTSYTSSTTQNKAVENPQTQTTEPKKDINEIIAKIKRQQSQPSISFQSPPKEQPSNIVAKPIPHTQSLSKFTAPQPEQKQQVENEESKSNTGNFRVKKAEDQLKKLEEDLVKKTNDLESTQSMVDEEKQKIEDLKSKLVSIEKKLQSTKNLKENVNEKKDNKETDEKRPIVFLMSENIDVEKAQILINFANYNMEIIKQSETLWNQISSNFSIMNTILNKFSLPFDLMNISQEINSIKQRRANEDIISSIPHLLNAIQKVVSFYGLNLVKKSFLDPIKKEISLGFDRLVFIEYELFQHIVEENHISFDEEFEFITSVRILFVIFMFNFNFNKFLAHHIVLLLKENALLKDGVSREECGIIEQQLFRCFDNILNIKVLWNRIPAFLSSLFSTLGLTDPDKTAHQILFKIQNELLETMKTQPINNKNFHPREIREMIANKTQPNTPQENLLDENVFEKIFNGESEQEQIPIKIKEQIPLRKRESISPLLLYRLFEPSFLSSNSNEIPNININTNTNINTTQDPKIIAEIMSSIQEYLFDFMDDYLSEMGIMRLERIYKDLNRNLSHVRDLKTLFHETNSQLKSKQSKYMMSQFIQESKENKENKENKEKENKEKENQEKTDKKPIHIITSTQELEVVSNQNQKQESQYKQESPYQNKSKKTDSTQMKQVYRNSKEQQIEKQSKRVSPLSPRLSSQKNLSKSPTPIKMQNSNQSSDQKPKMMIQHLDFEFIRDHFEENYPSLFNTPNIKQGLLNWKTSNKKSFKKKFIQLKEKFLLIYKDQPSSPVDFPEEWIYLDSSIRISLDSTKSKKGGSFSIKQSKNVYSISSDSKTDLDNWMVLIRKATKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCI4</accession>
    <name>A0A9Q0LCI4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCI4"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="83" mass="10031" checksum="C1C60948CE5AAD23" modified="2023-09-13" version="1">MRSKLFREKFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIEELETGIDYFQLNQTNPNLFDLLIKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDM7</accession>
    <name>A0A9Q0LDM7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDM7"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="455" mass="54371" checksum="0F79706CE2253F58" modified="2023-09-13" version="1">MENYLNLEKLSNDLKNLFQNKNEKEEESYFDFEIICEQNQISFKTHKSILSSRSYYFKSLFNSKMKEYQENKLILKDVSSSILFSILNYFYSGKIEINLENAIQILIFSSKYLIDELIEITSNFIKKNLQIETIIDVLKLSESMNLNKLLGFSYKFISKNFEEFIKTPFFLELEENHLNSILSNDYISTKESEIFQSIIKWGKHKSNINQETDLEKEEKRTNTKSNFKYILKEDLIPNQISEKLIQFQKLQKSKDEKELNQFIEKENQNSFIFKTRFKSSTIIKEKEHFDKLKEWINDDEFFYKMKKGFSAKKDGFDCKKWHDICDNKGKTLIKSKWKENYRNKDDGLIEDENAFIFSLRNDKNDRKAEKFQIKQGEGDHALGYYYSNYGPYFGGNESYYYPDFHLNSKLTSGWTNFGFSYDLPNEFRIRTTEAKSYLAGSYNEWIVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEA1</accession>
    <name>A0A9Q0LEA1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEA1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33907" checksum="C4537A4885A916A4" modified="2023-09-13" version="1">MEAFWITIIALGSILFILYCVCYLLFAYRFHLLTMELSKGRQRIKKFENADSVKAKLFALPEGSLNAISFKRKKKKKYFAVIALIGIAPTIYPWRYIQLGWETVFYSCYFGAAASVVAVFIICYYLKKIKKTTKTKNKVAFAISSHRIFLVGNPNEHSIFSWEISKISTIFARDEKQNSKTLVFKFEDEIEEPEFQFLPNVDQINLFIEELKKNLLNNKSNEIDYEKLELSNSQQVWILDSQVIDEIIDEDGFMELFDNRKPIDNDIEDQRLMETSSNKSEIEMIEDKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEG7</accession>
    <name>A0A9Q0LEG7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEG7"/>
    <dbReference type="OrthoDB" id="438783at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF61">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_2, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="405"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="569"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="715" mass="83052" checksum="31196D7BC309A3CF" modified="2023-09-13" version="1">MINNNNNDNNNINNNNNNLIDTLLIASINGNLKKIKRLVSYGKSLSIRDKCTPLLLACKTNNNYDVIKLLIDLGSDVNETNNQTCLHLSILNNPQLNVIELLISSGCRINSQDAVKLNKFKKYFSIKIYLIFVLIFLETLHNACHHQLPKEIIELLLKYGATPKITNDVEILFLQIFIFSDTPLHLACIHKSNNETIRLLIKFGAVVNSWNFNTPLHIAVFNNISTQSIRLLIDSQSEGLTPLHLACLHARYETVLVLLDCGADMNIKDKGKIPLDYAENNLITQKIFQAHQSIVEDFRQLFLRQEFCDLEIKTLNGSVFAHEIIIKCRIGKSQMKKFTTFFETFEKPQVVKFIEFLYTGELKETEKEIITSISERIQLQNFQRKLGKKGLIKDLTKLYFDEASKDFEVIVENVSLKIHKVILLARSDLYRGMFLYVSDPSNKVTDQSGRSIDSIKALFQFLYTDTIKDCSESVIEELKDASDYYQLNINGMIDPYLKVQEFMIKTQCCYPNECLYYLILTNGDLEEAICLRSLCLLQESQQQQQNPYYQYQYPYPFPFCFPNQINKPETEKETETETTEKAKNLKDSFSEKTKQKSKKRKEIPITTELLHKFLFQKPAPRWQYRLDAFKLLDSTLVNGWPDECEAANNIDQKTQEKQSFRVEVSSRIFTYYLDDQRNFKTKQNLKRGLVQFFQSRGFAQSKEVKNKLIFIREIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFE3</accession>
    <name>A0A9Q0LFE3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFE3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="220"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="337"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="510"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="641" mass="75184" checksum="AE317CF3BCDD3A38" modified="2023-09-13" version="1">MNEIIFFGQNEYPKLFKNEPDKITKPIQFKFENKNKNENENENENENENENENENENKNEKQIKQIATGYFGTIFLFNNGKAIEYLRDSKQNPEKIQIEENIQKATVGFQNKAILTKEGNAFAKGKGINSKNPNQFTNISSLIEDPNDRIIKDIASAWSSIYLLTSNQNAYGIGLNENCQLGFDFKKLKKTEKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGCGNNEQRQLGLGESRRKEIKIKKLTQIQNIPKGKIIDIQCGYAHSIMLIEEDDEKENPKRKFYSCGRYFFNGLEKNGDTYEFTEIKSSLFENDDNILDFSVGCFHNFILTSKGKLLRFGYNEYGQLGTGDTENRPVPIQIELPELRFNEEISNYHISCGFHKSFIYYSPFLSSFSNLEEDLIKLFERKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPNLYSEIKEIINSNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVKDYSELSNNSFQILEYWIYSNQIKDEIQITQEIIDEIKIGIDYFQLNQTYPNLLDLLINKFNIQNPKQNTNQIQIQIQNQNQKKKDKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFI8</accession>
    <name>A0A9Q0LFI8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Phosphatidylserine synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_10292</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFI8"/>
    <dbReference type="OMA" id="YMENCNS"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5071449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="395" mass="46872" checksum="6E7D72F2F9B89600" modified="2023-09-13" version="1">MLRISTIFAIIIFAIFFIHFTFFSQVYSRLTQMRITVGMVVILFIILSVPYIQDSYFNWPHPLVFKLAKAISLLYLGFVSFLLFLSREEARKVFLFFDSSLGKPLVEFDYAQSCDIYTPNDPTSNFRNVKNVVLDVYVLAHLLGWFVKTLIFRDIVMLWGISIVFEFLEITFQHLLENLSECWWDHIIVDALGCNAIAMFVGMWVIKKAKLQKFHWFGHTIENENEKDNQQKSKPRFLSLSWFSQTWKNYHWDMFDSPKKFFAAIFLFSFAEISELNVFFMKYPLWIPPEHPLNPIRLIIFALSGVETIKEFYEYINTPNSKYHFQMYISFLVVIIETILGIKFGQGLYPRNMPTYIRNSWIIFFLVFGTSSFIHFYRKNKSLEKTSPKNPKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFT7</accession>
    <name>A0A9Q0LFT7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFT7"/>
    <dbReference type="OrthoDB" id="410551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="152"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="582" mass="67611" checksum="D4CF6EE3876DCC85" modified="2023-09-13" version="1">MNDCLFFGYNTNPIFIKNKPNKIKKPIQFKFENENENENENEKQIKQISSSYYSTIFLFKNGKAIEYLNENDSNQNPEKIQIEENIQKVTVGEQNEAILTIEGNVFAKGYNINPNNPNEFINISSLIEDPNDRIIQDIVSGFSSVYLLTSNQNSYGIGSNSFGQLGFDSETISKTEKPILMMKNVSKIFSGTGSFHVFLLNSNQELFACGYNEYDQIGLGESIEETNIHKLTQFQNIPKGKIIDIQCGEYYSIMLIENENENPKRKLYSCGNSGLNGLDTDTYEFTEIKSPLFENDNIRDFSVANSHTLILTSNNKLIGFGYNDYGQLGTGDTNNQLIPIQIELPKLRFNENISNYHISCGFNNSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIKAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIIDELETGIDYFQLNQTNPNLFDLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFU4</accession>
    <name>A0A9Q0LFU4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFU4"/>
    <dbReference type="OMA" id="LQITCID"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040380851" evidence="7">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="8">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="144" mass="16278" checksum="A5700FE8F6B562A3" modified="2023-09-13" version="1">MNFSLIFLLFLPILFNFCFTNDWTDCSESNDTLKIKSLTFIPDPPESGKLFTIHLDADVLRKIDAATAYATVYFNGIKILQIQENFCSIINITCPITDPVLHFQVTETIPSYVPSGEYSGQIEVIDNNNQQVTCIKYDLPIVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFU6</accession>
    <name>A0A9Q0LFU6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFU6"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="262"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="479"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="588" mass="68649" checksum="68BB2B074A1CEA45" modified="2023-09-13" version="1">MNEILFFGSNQYPKFIKNEPNKIIKPTQFKFENENENEKQIKQISSCFSRTIFLFKNGKAIEYLKYPNKKPEKIQIEDNIQKVTVGVHNEAILTKEGNVFAKGIDINTNNPNEFINISSLIEDTNDRIIEDIVSGYNSIYLLTSNKNVYGIGSNEDGQLGFDSKTLPETEKPILMMKNVSKIFSGNSSNHVFLLNSNQELFGCGNNQFWKLGLGESRKYETKIQELTKIQNIPKGKIIDIQCGNNHSIMLIENENEDENGKRKLYSCGYSQYNGLGKNEYIYEFTELKSSLFEDNNILEISVGDTHNLILTSNSKLIGFGNNYDGQLGTGDTNNQSIPIEIELPKLRFNENISNYHISCGYNNSFIYYSPPFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLQEIISNKSIQESNQIFEMIYSNRIINPKLYYEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKKYKFPKLILIMRSKLYRGMFLSVKEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIINEIKIGIDYFQLNQTNPNLFDLLINKFNNQNKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG78</accession>
    <name>A0A9Q0LG78_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chascon isoform d-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG78"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="694"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="746" mass="89006" checksum="48306E90AC2826EE" modified="2023-09-13" version="1">MAFYQLKLEEALSKEKLKIHALNSDVYLPIKKIASKLSKFFKDQQGFYPRPKIKPKRAKKKPQSKTKGKKGKKKKKTKKAPAKRNPNQRETQINDPFYQAYHTREIALERIPAYKMLVTEVNKREKLRDLYNFLISPVVMATLLGLKPCFCFDLVFEMKINIVNVPPQEFYDLYKQFPEKYEQTPRLIAGLYSLTLKNVISEFFPGKFVFLLFLKGSEWSFFAVNRNHPLSVKYLSGEMTGCKPNKLYFIKREINLAHKELGEIYGYDFSNCCLFQKNEAERIQLQKDQEELQKQKEKATEKKKKEIEKKQKYLRKQMSREKIIGKIFFEKRQKSLETTMYSCQDLVWELHEVETGMKKLEGYRVWFEYFLSKLKSIKLGKILIDIREYQLKVNDLMGKDGINAFYSSKEQQVLDWMQMIEKLSEQNKSQIKTMSPQDLKKSDIILDQIDDDQDDDQDDDQDQNQDQNQNQNQNQNQNQDNRNIKSDEILKINENINANDSSNINENLNTNEQLLQNSKSKENIIQNLKTNEQIIKKANEKIQELNETIIQSTDQKMQELNQKISEELKQKQNEKQNEKQNENENENKKQNEKQNEKQKENENENQNENENEKQNENENENENEKQKENENENLKEKENEKENEKQNEKQNEKQNENENEKQNEKQNETFKIEEINEDETFKIEEINENETFKIEEINEDEKQYEIEITETKVKIEEINEDETIETQKEIKKETRVKIEELSDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGL3</accession>
    <name>A0A9Q0LGL3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGL3"/>
    <dbReference type="OMA" id="LEWAENY"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000004">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="242" mass="28024" checksum="27DFF2E67E058E3D" modified="2023-09-13" version="1">MPRKKSQYSFTKTKKDGKQRKAKLIEKVQKAVEQYKSIWVLSFTHFKQEYFNQIRLDWRDSELFLGKKKVMLVALGRNSNDEFRPNLSKLGDFLKGNSGLFFTNEKEEDILKYFSQLRVASYAIAGETATETVTLQKGPYPQFPHSMEPFLRNLGIPTTLSKQVVNVVADYIVCEKGKPLTSEAARILKLLQIQMSSLNVQCLCCWNNSKITTFNQNNNDKVDKEKTNSNMEEEDEKEKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGP1</accession>
    <name>A0A9Q0LGP1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGP1"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="610"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="705" mass="81618" checksum="1282B630E7680D0F" modified="2023-09-13" version="1">MFFFADSDSDSDSENILKIEEAISENNLEFLKNTKIDIDIKTTNNMTFLHFACEKLASIETFKCLLEKGFDINVIDSEFSKETPLHTLCKSNPPFANVKFLLENGADVNAKDINGTTPFHLICQTNNAKTLIELMLEKKAEINLQNNYGLSAIHYACSSFPSLEKIQTLLENGADINLLTKSLYSPLYFLVHNSKDYSLIEFLLSKGANPNIMNIEGLSPFLLLLQLGLHEDYIFLFLKYGADPSQINPKNWNSVLHQFCVKTNEKSAKIFQILFEKSEFETYDIKNKSGQTPLHFLCEYAGDITLLKFLLEKKCDVNLPDNNNQTPLLIVLNSPLFRPEIAKLLIEYGADVNVKDSFGQTPLLLACRTNHDAELLQKIIDCGADFSVRTETGKSPLQEASFGNTSTECLELLLKHTPQQDIDNEPGERTSLEYALSSYRKEAIIFLYGSWMDFDLSKGFYLDSHSKSLLEHLRSFHFDLKQFLIQQELTDLQISLNEGGLIKLHKDILFPRFDLILLDDPQKETQKRNQFLENLSNVCKDKSREKVMEFFEFVYTGIIENKKFKDCYQFLFDFIQELGIESPKQWIDKKKGRNGIISDFQKLYENDKEKDFSIVVESRDLKVHKVILALRSDLYRAMFLFVRDNSNTVQDYTQRSYFEMTQIIKFLYIDSIDQEFIKNHYSEMEETIDYFQLNPNSMLKWFAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGY4</accession>
    <name>A0A9Q0LGY4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGY4"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="489"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="773" mass="92245" checksum="3CDB68C4582EBC80" modified="2023-09-13" version="1">MNQNLFQESKKLNFKVNFVITSLQEFKPLSSIIISLRKNSNKFQTKEINIDSNGKAILKQKFSFPLSNIKNNDFSNQIFKFETYFKIPQIQNDYKKITFVNFDLSKFNPNELFEQKKISLNLINLKEKKEKGEQITFLLKLELDQNNQNSNFYKEENKFNQKKIPKKNLEQEILDQKVQISIEKKKNQKLMNQIRNYVSKYSIKKDKMDQMKKEFESKNEEMKKNNESLLQKINESKKMQNELMENKREMAKMESQIENLKIQNSSLDKSQKELKKENEELSESIKKYQQDQQNIKELHSIQMEKLKSETDLKQDELNQKKNHLDKLLESKNQEFGLLQKELEKKTEENIIQNKILISLKNYIRKLNNIQKENWIIKRCFFVSEQIYSNGIPVSASLVTQFFCNNGYLDGNNSNEPISRVLIESFEMLLKKFEKKNTNKIYWLLSNTIYFKHLFHKIFLSKTRQQQNPNEEYSNFLQHSFLPKNNNQNEKILKLISEIDRLFSVIYNLIIEKIRKRISTMILKILSQKSSKSNNPIRKLPDESYYNPQILVNYFDQLNQIFQKNSFPLDLINSIFSQIIYFIRSIILNSFLNNKSICRYGFAMDFKLTLSALFDWFESSSFSNLKENLDSIKEIIDCVLANKLLLMDTLSFSSCFSVCKSLNLFQVHKLLTNYGIDEFDQEKIFPKDLELFYNQAIIYYSKKDLIHNFDPKKLELDESFIFQIENNFKQIQIDKWEEIEIPKAIQDREKTINIIKNEKENEFDSFCLLFEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH14</accession>
    <name>A0A9Q0LH14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">32 kDa heat shock protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH14"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DUF4704" evidence="3">
        <location>
            <begin position="26"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="672" mass="80046" checksum="1635952FF049EC02" modified="2023-09-13" version="1">MPNWKQKYIRIQERFSAKNQMRSKLARDILVLLSKCQIIQNNKIVFALLQQILRIISKNISILIDDLVEINFLDPFIFLLNNSSEKVRILCFEIIYHLHKYLLLIKKKDEKEPKQLISTPNKNKNKNKNKNKNNKIEQKNQSQEIYQKIDLHKSRLNSPDGFEMFHNVVIRFQPTQKIVDQLFNLLLIKLPYSQNMENQKMIKIQTPWILRTLFYLIRKNPNQVGLNIANRVFSLFNGNEANVKIFASQNYWQEWILQGFYFSEFSLDNSNDNPKDNSNDNSNDNFEQKINNTLLSIIKFVFKFIFINQEMVALDILKILNTLGIMEKDEQEFAFEQKNVFIHIFYQELLVGIDESIEYEMSKINLKESKKEYSLIFKSKFLDKIKKIKGAFESNLGDLVILIGYFILFDNKKEAMTLNFSQKKPKQSFVDPTTQLNQKLVQNLVLFLDKFGFIDSGLFFRNEEQGKQVFRFVLLFLFFEIEVSEFQNCSKYLDMLQRLFYIHGTRSKIEKQILEERKELIFITTSYLFKVLRFLDENENENQNENENQLENQNQNANSKINKQRLIAVHLQTLIRNFYEMFASFLKLQNGGNLLPKNIDLTKFSTYNSTELIDIFRSKKWEFAIKNQLSSIGIQFSEDIQERRNRYEEEIQNQYKKFESKLTEKLMAKKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH34</accession>
    <name>A0A9Q0LH34_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH34"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="191" mass="22286" checksum="7704E10809A55DBE" modified="2023-09-13" version="1">MVFLILKSLFGSTTLSLFAACLFVVTCLLSLILIFFRIRTIIQSQTETETETEAERGLSLGTEIQTRLESQNEIIRYLRRNQETQLLELALSSRDFSEQDYERLLSLDNETPTKILQRASQVEINRLPVRVISKNEELRLAQNQRFCSVCLSEFKENDVVKTLPCFHFFHQSCIEKWLKIKKKCPVCDSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH60</accession>
    <name>A0A9Q0LH60_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger cchc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH60"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="720" mass="86251" checksum="3F59BE5A6AB80978" modified="2023-09-13" version="1">MKPNNPQIPFKNFVLPLPRNKMEKLISNNQTFQTCDLMNFDQDELANLDPKQFYNFQQFNNYPQFNYQTNLQQTKTNKNLNKNLNKNLNKKHHSKNNSKNNSKNNSNSFPQQNFNSDFNSYLNSAENFNQNQPFHSDQNLMQNQMDYESIQQQQEMWLNLEKHKAFQNLSSAMNTEDKTDKKEEEEDEKEGYQYQFQYQNQFPNQFPKNQFENQKELQKRIKKANHSTSKEEGNDYLREKSFEIPSQQISEESTDLSNENLTESELKERKEEQICRFFLQKPLDFNHKSQRGNPSFGTVIYSYIRKTIATHQKKSNQDQKYLHFVDETEGMINSGKCDAKLAKWIVKRRFLARKKKRRQIKRRKNKQKSKPKSTQTQNQIQNQNQIQNQIQNINQNQIQNENENQIQNINQNQNQNQNINQNQNINQNQNINQNQIQNLNKNQNKNENQNQNQNQNINQNQIQNINQNQNQNENENQNENENQNININENQNINENQNQIQNININEIENQNQNQNQNENQNENENQNQIQNQNQNQNQNQNQNQNQNQNQIEIQNINQNQNENQNQNQNQNENQNQNQNQNQNQNQNQNKNQIQNIIENQNQNQNQNQNQNENQNQNQNINQNININENQNQNENQNQIQNQNQNQSKSFDQKFFDQKSIEPKSNETKSIEPKSNDQKSNDQKLNNHKLIEQKLNEYNLNQKEFQQKSIDQKSIDQNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH70</accession>
    <name>A0A9Q0LH70_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA cleavage complex 2 protein pcf11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH70"/>
    <dbReference type="OMA" id="QISEHYI"/>
    <dbReference type="OrthoDB" id="343582at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="485" mass="58499" checksum="D66E96A47D9791CE" modified="2023-09-13" version="1">MNSILLTEFQKELKTLEKPNKDKISILTSFAKVHVNLSKEITRIIAIHIRKVEQNKRLSILYLIDSIVKLAGNFYSKEFEKDILAIFIHVLSGSDMKTKFKLQELVETWKQKKLFGEVRIKMMKKKLLESLNEKIKEQWIVPEKDSDQNTENNQFNEKMEQKLNLNQNNQFNQKMEQKSNFKKVQFNEKMEQELNLNQNNQFNQKMEEKSNLNQNNQFNEKIEQKSNFKKVQFNEKMEQELNLNQNNKFNEKMEQKSNLNQNNKFNQKMEQKSNLNENNQFNQKIEQKSNLNQNNKFNEKIEQKSNLNQNNKFNQKIEEKLNLNQNNQFNEKIEQKSNLNQNNQFNQKIEQKSNLNQNNQFNEKMEQKLNLNQNNKFNQKIEEKLNLNQNNQFNQKIEQKSNFKKVQFNQKIEQKLNLNQNNQFNQKIEQKSNLNQNNQFNEKMEQKSNLNQNNQFNQKMEQKSNLNQNNQFNEKIGTKIKFKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHH0</accession>
    <name>A0A9Q0LHH0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tm2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHH0"/>
    <dbReference type="OMA" id="HANCNSA"/>
    <dbReference type="OrthoDB" id="10257855at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF7">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040233538" evidence="8">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="125"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="21673" checksum="D8774E20F71C62D4" modified="2023-09-13" version="1">MKFIFLLILFLLQIKIGISIDCVDVQASLLDCNYSTNCTFGEDTETSCTVPLSINCSGLRDFNKTHTCQFCYQTDDYLHICSNKTSCHVGRKESYYLATCDVRDDIFCAGTRTFPKYQYCNFASKKSWKKTLILSITLGGFGGDRFYLGNYGAGIGKLFTLGGFGVWTIIDVVLIATGYIRPSDGGFYQDYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI83</accession>
    <name>A0A9Q0LI83_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI83"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="234"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="351" mass="41524" checksum="C60273323A40F250" modified="2023-09-13" version="1">MLIENEDENQNPKRKLYSCGDYELNGLGKNKDTYEFTEIKSSLFENDDIILEFSVGNTHTLILTSNSKLIVFGGNNHGQLGTGDTDDQSIPIQIELPKLRFNEKIYNYHVSCGYEKSFLYYSPPSFSNLEEDLIKLFRRKEFCNVSFKTENGEIISAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEETIKRIYLNEKEKDFIIERKEKQYKFPKLILIMRSDLYRGMFLSVTNDTSNKVTDYSELCDKSFEIFEYWIYSNQIKDEIQITQEIINEIQRGIDYFQLNQTCPNLFDLLINKFNNQNQNQKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIE6</accession>
    <name>A0A9Q0LIE6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIE6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="142" mass="16380" checksum="A52CD4543A1CF98B" modified="2023-09-13" version="1">MSRELKEIVGLTKLNDFLINNKEVQIKEQIKQKLDSKQNELKEKNEKNNKEKEEKKPVILNIENSYDFSRYKEREKWEGPIKPESIKTQVSKPDIDQNSILSCNGICSNCAFKNLCGFGLQNLTEKLADVSVDSIKKLASKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIE9</accession>
    <name>A0A9Q0LIE9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIE9"/>
    <dbReference type="OMA" id="KWSKVIV"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="125" mass="14052" checksum="10EF13F2EBBEE472" modified="2023-09-13" version="1">MPPKKDKGKDKGKDKGKGKGKTGKSDKNLGKQKKSKKKKWTKGKVREKVIKPVLLEKETFDKILKEVPKYKVITPSIVGERMRVNLGTAKKIISDLETKGLIKPVSKHSTLLIYTRSIEPKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIK2</accession>
    <name>A0A9Q0LIK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bud site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIK2"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1003" mass="117802" checksum="79E266C159932E5B" modified="2023-09-13" version="1">MSDVLSLTHEAEEAIFGESLLAREIQLKLIKTGLGPLDLCHVIKTESFNHKKKTKTNQKAHKVVGFYHYVIGVDTSNIGSIVKYLHLLLKSQENARFLKKKWSIVSCSYYSFNAFSKIDLHIHFTLPNKLQFFFIDRGGVCVDVEPHITSLISSVQKPNALKTENDGLNESTFDEDYLNYEENLNEKNSNQKKLKNSNEKNSNQKNSNEKNLNEKNSNENKFKNQKNIKFRNRNFRNSKFEQTNDKSFSTTEISSGKDFEDDKKFLMSDNFGISDEKNIKISQNDDDDYDYDDYHITDNNDNYNSQDNLEKSRINKHTVTRINANQSSQKIRKYRKQATVWDETLISSFFRKVISHYINPFQKIPIVNIVENQFDYENENQLFNLTEAVFWKGKKLGCSQPRIVPSNGYNFYVKLVQRYLFGQYRFNLFIKFFTQFLDEEPEVAIPISKAYLKLKDAKSALTVLTNQYKKKINSVPLISQLIKTLLVSNKINKAVKLARHLTSIVPFYPKPYLLLAKAHLRQKNFHSVLVNLNNIPFQTNNNCSRNSIICFDEMFPTPARITIPNSSKFKANFEYLCSQNFEDPIFLKKSGKIPEIKEKSKSKFSDLPSLSLKNPLEKKIYKILIDFSNEYGWERMMESRVEVFQKNIRSLVGNKKKKRVPFGEIIDYNFQNFSEITQKEKDELIEIIEENESKMIQKAKNMKNMKNMKNMKNIKKIQNLKKMQNLKNIQNMKSNQGKDTLIDNQENSYSISTEISTEDSFARNFWNENANENLNEKFADESNAFFCEDHIKLNQEKSTKRILKLRSAPEAQIKPYYVRIEYQKWLDILIQYLYSDLKCFNTFLKNEEKTKKNYENQSEVEKYSYSDFDLIGDLARKLKNFRVAKNSYILAIQFSGNRIKKVNRKICLKLLEMNIKRGTLNEVLVTANRLLYYLDKKILPYEEEFLFKNTIEKSIFKLIFRNGLVSLNSFISKRFNEKDNKIHPKLKDLIELAKKFEIDGTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ32</accession>
    <name>A0A9Q0LJ32_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ32"/>
    <dbReference type="OrthoDB" id="5591912at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="977" mass="115422" checksum="C6250E1FE589A268" modified="2023-09-13" version="1">MSKTNRIQANLLDRELRKIDKTQVYFSSHHLNILSKKIKRSLINFKISNDPKNNKLLRIKSDKKSIYLKLKSKKDTNIFMQHYREFLIENQNQNQNQNQNQNQDQNQNQNQNQEDNLGHWIPLGNSANTKNSKSKSEQKKPNLQLKQRIQQNQNLRAKSEQKKTNQNLNQNQNQNQNQNQNQNQNLIQNQNQNLRTKSEQSKISQNINLTSIPTQEIIKQIPIDILNSQYQKLYSGFVQFENDKFRIINTNKTVEHLLPKNLEIQDKYKNEGILEIKSYFSNYVLKFQYKSDLKQFLEYFYLFINKKPETKKIVSPSQKSPQMENKIQKPKVIQEKKTQININNNNNQYFQENANFSIPSPTKKPLYFWQPNVFRVGILDPSFQVIDFGEISINNELLDFSSRTYFSQNIPIYLIEFFPSSINHKMAKIRFPDLLSLIVSFYSEDQCGKFEQIIDSSKNKYSHLLPKSVGNQKPPLQRNEAYFSRENQIILDQNEFRYENQNQIQNQNQNQNQIQMQIHYDLEKENEYEKEVIQQQSENNLISNSLDNQEIEKKEEISIQNDEDYQDIDFTDESFSKANENQFMIQIIGEESNKIGNGIISFEENNILINSDLINESLVYKKTKLKMNKKNLLRIEIISSNPKKKFQIIFDSKGDEIKEKERRKETTTTKSEEKGTTKIKSKKEIKSKKEINLNQEIKSKNEIKSKDEINSKDEINSKDEIKSKDEIKLKDEINSKDEINLNQEINSKDEINLNQEINSKDEINLNQEINSKDEINSNQEINSKDEINSNQEINLKDEINLNQEINLKDEINLNQEINLKDEINSNQEINLKDEINSNQEIKSNQKEHKQKKRKMKKIIYNSKIKENLNQSRNKSSNQKIKQQQVNQRINFSIFIHNKESSSKKIGILSINNKKIEIKREGDQKTIFGFADLRFFKSKKDPKIIRLVSGEKSEVIEFFPNEIGQFGSSLKEFMNYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ58</accession>
    <name>A0A9Q0LJ58_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ58"/>
    <dbReference type="OMA" id="FNPKERC"/>
    <dbReference type="OrthoDB" id="535509at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053215">
        <property type="entry name" value="TKL_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45756">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45756:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="231"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="471"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="908"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1098" mass="126789" checksum="459FA376B95A789B" modified="2023-09-13" version="1">MNKLNQFPKWKSKDVVIKKFNILNDEKAKKEFHNEIKLATKLNHPSIVRIYGIVEMDSMLGIVMDYALEGIKFLHSKSIIHRDLKPENILIFSNKPKISDFGVSRVKEHTMKVTKSTDSFRYSAPELFNEGNEYDASCDIYSLAMILYSIFAKKEPFDNLNFIQVTMTVMNGNRPEFPNNFPKELSELIKKGWNFNPKERCSLDQFTQCLKKLKPSGINEQIKPIPLKELQIESKPFSIGETCQIFKAKWKSKDVVIKRFNILNDEKAKKEFHNEINFATKLNHPSIVRIYGIVEIDSMLGIVMDYAGEGIKFLHSKSIIHRDLKPENILISGNKPKISDFGVSRVKEHTMKVTKSTDSFRYSAPELFNEGNEYDASCDIYSLAMILYSIFAKKEPFDNLNFIQVTMTVMNGNRPEFPNNFPKELSELIKKGWDFNPKERCSLDQFTQCLKKLKPSGINEQIKPIPLKELQIESKPFSIGETCQIFKAKWKSKDVVIKKFNILNDEKAKKEFHNEINFATKLNHPSIVRIYGIVEMDSMLGIVMDYALEGDLKNKIINLTFDEQIRFSLDIIEGIKFLHSKSIIHRDLKPENILIFSNKPKISDFGVSRVKEHTMKVTKTTGSFRYSAPELFNEGNEYDASCDIYSLAMILYSIFAKKEPFDNLNFIQVTMTVMNGNRPEFTNNFPKELSELIKKGWDFNPKERCSLDQFTQCLKKLKPSDPRKPHSPNRTISPNKTNQSNQLQSPNQKPVMNQFHSPNRTISPNKTNQSNQFHSPNRTISPNKTNQSNQFQSSNQKPVMNQFHSPNRTISPNKTNQSNQFHSPNQKPVMNQFQLNNQSTENQETTNKPKSLSRTQKQSNLNRVKSPKNNIENKIPSPKPDSNSIISDILPKKLENLKKDFDASEMHNKSTTFHFFATQPSLDIDILQYFIESGADLNQKDWSPVHYFCRNLNITYSHIELLAKNNSNFNLNGWTPLHDLCRNKSITKEIVELILEKTKANFHIQMFSPLHELCGNISITTDILKLLIEKGLNFNLKMLTPLHFLCNNRSVNEDMIKLLKETNANFYSKTQGMWRIGRTIVSSKTPKDLLKENLKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJH0</accession>
    <name>A0A9Q0LJH0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kruppel-like factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJH0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="173"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="485" mass="58856" checksum="8555BDA5961C3B44" modified="2023-09-13" version="1">MLIEMKIKIQKENFIHELEIQNQLIPIQIELPKLRFNEDISNYHISCGYNKSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKEIIQVNDYQELNEEKFEILEYFDNTKQITKEIIEIDDYNELINQNQIQNQNQNQNQIQNQNQNQNQNQNQNQNQNQIENQNENQNENENENQNQNQIENQNQIQIQNQNQNQNQNQIQNQNQNQNQNQNQNQKNQNQIQNQNQNQIENQNQIENQNQNQIQNQIENQNQNENQNENQNENENKIKITKEILNEIETGIDYFQLNQTHPNLFDLLRKEFIKFEMNERKKITNKKEKENCFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLB7</accession>
    <name>A0A9Q0LLB7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLB7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="484"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="591" mass="69061" checksum="7B00C6185C8A5016" modified="2023-09-13" version="1">MNEILFFGINEKPKLFKNEPKIITKPIQFKFENENEKQIKQILTSQFSTIFLFKNGKAIEYLNDENSNQNPQEIQIEENIRKVTVGDRNEAILTKEGNVFAKAKGINPDNPNEFINISSLIKDTNDRIIEDIVSGRNSIYLLTSNQNAYGIDSNHFCQLGFDYKKLEKTEKSILMMKNVSKIFSGNSSAHVFLLNSNQELFGCGNNYHRQVGLGESRKEKKIQELTKIQNIPKGKIIDIQCGFAYSVMLIENENENENLKRKLYSCGYYGLNGLGKDKNTYEFTEIKSSLFENDDIIDFSVGNAHTLILTSNSKFIVFGYNKYGQLGAEDRNNQPIPIQIELPKLRFNENIFNYHISCGFNKSFIYYSPLSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNEIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNERIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTDDTSNKVTDYSELSNKSFQILEYWIYSNQIKDGIQITQEIIEEIQIGIDYFQLNQTNPNLFDLLINKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM74</accession>
    <name>A0A9Q0LM74_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 4g1 isoform b-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM74"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1020" mass="121671" checksum="970C7EBDD12035EF" modified="2023-09-13" version="1">MLQLFLEVSKNLEKRNDLETNYFEKNETLHQIWKEFNPKNTGFEIVEKMKQFVPLFIENYFNWYPPQEKTDIFDFELLPDDLKYQRELISEEIISAIENHSAHPLQLINSIITYDCFSFSSISNFINQNQNLNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNLNENQNLNENQNENQNQNLNENQNENQKQNENQKQNENQNENENQNQNQNENQNENQNQNQNQNQNQNQNQNQNININQNINLLDFEENLETTSDLSQESNEFGETEMEKEELNNNVQKYSQFDHLEIRKSFKISKEIDFNSLRSLQMISILSRSKYNRTILRCFNVLEILISYIKLITQIINIIQIQRKTKPEIAVNNLFMVQFIHTQVLDIISKFFKIHEVLPPREMLTEAKNQKLVSSLLECFEEMLKLRESFLFTRKQYDLLLTHLDILEKLTNLEIYSEEDEANIVKLLFNFFKQPNSSLPNLGITRNQNQNQNLNLNLKQNELESFSVYENSLSDYYKTKFFHFEIASRKTIKLESSYSNLTIQENHLIEKFTLNHLEFQLFNTSMNFLLNLLKDFGIEEFAANCNVIHNLREFAHWAFIKLSNFLIQKKNQKKTGNPNQINNNDNQIQKPQENLHPKKIISLENFDFSRSQEISGFIKPSYFINKEQQNRAQNKYPSEPYIDELFQKFRLFINTEFSQKSTLLGNYISQSLKRFEINQEKSQITPKLSAKEIVSSFLQRFFYIYIDIFSSFENDPPLVKKSLQILNNEYPALQFYILFEFEKNFQPDDWKTIYPKLFWKVFLSNYFLFDPQFNTKNDPKFVSSRKCLSILLTKISSELILNSPISIYDLNDFATENIDNFSILSFWIKILSYIFTQNVKKAINRLSKMNGFETFTTILSHLLSSSPNNDKYFSKVMGIFHVFLCYKKNHLRLFNHPETYEMLLSWIFYPKTKAFAHYHLSEMMKKIPNNYHEMNILPFFNQIISEIFIREKSLPSIKINNLNENLNENLNENENNLNENENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNT6</accession>
    <name>A0A9Q0LNT6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNT6"/>
    <dbReference type="OMA" id="WHNAFAQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="160" mass="20424" checksum="D92B213252D9E59B" modified="2023-09-13" version="1">MDWIFVPDDMEKSFKTVLTNLIFLKDDKNAKRKKMRDLRKKITSFETEQKEKEKEKLKEQKEEKEKIIKEKEEKKEKQKQKEEQKKEKERKQKEKEIKKTKTKRKKRKKKKKRRKRKKKKKRKEKEKKKRKKKKKKKKRKKEKRKRKTRRKTKKKKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP43</accession>
    <name>A0A9Q0LP43_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exosome component 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP43"/>
    <dbReference type="OMA" id="MIISLNH"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="217"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="467" mass="55040" checksum="76EE0610C1D07E6F" modified="2023-09-13" version="1">MQKKEQNLLQKNIGECLKTVFKTTKKSNSFIKTGDYLYLQTYSSFLNQMNDLSDTILNTINICTQFLKLDPEKSILNEKTHDEKYKIMSHLIGDIVDLIDKHIDDAIEDRKAKKDDKTRGIIKKVGNFKIFHAKQVMRPQFTFQDKIDNFGPFIPKFPAKKNSLIQTNSNENNPQNHLGNTENSHLYEYEILHSKLPNHLFEIPEQNSFLEIQDTPLIFVDTLEKFKEIISHLKKEKEIGVEVENHVYHSYQGFICILKISTRKQDILIDTIKLRSNINEMNEIFTDSNIIKIFNNGSEQILHLQRDFNVYVVNMFDLFISSSLLLDSNDHSIADVIKIFLNIQIEHEFDLVDWRIRPLPKEVLEFARQELHYFIPLYDKLRSILIMKAKEENQNQNQNQNENQNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENQNSKSKSKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPC4</accession>
    <name>A0A9Q0LPC4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Wd repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPC4"/>
    <dbReference type="OMA" id="WDTKEIQ"/>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057852">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057854">
        <property type="entry name" value="TPR_WDR11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23751">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23752">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23753">
        <property type="entry name" value="TPR_WDR11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR11 first beta-propeller" evidence="3">
        <location>
            <begin position="13"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="4">
        <location>
            <begin position="404"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 TPR" evidence="5">
        <location>
            <begin position="854"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="818"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1168" mass="135461" checksum="54C9D24CF7175E63" modified="2023-09-13" version="1">MEVIKRIIPGALDKENIGALDWGIQNLVAYAARNTIVILNPQTMQVVQTLDGHKANIKSIKWTRNIFNREITDEYQLLLASGDKAGYIILWDIFLGKALGTIFSDIAQHSPVYAMEWIGQNPSYLFTFHFPSIFTLWSIKKFPYQRPTKVWDLELAQRIQSISFNPFHDKELAFCTEEGSLFIIEDFNTSEKPKKIQYKFRVDTTKSEQKPEHKPKKSTTPKKQVEQPKTNTLRQIKYSTTHKDMLYFLFPREIFILDLTISQSVGYTEIPQTKYSLSEMIYLKDSQKSFVCLHEDGSLSGWIQESNSKMFFLQISSFSDQFRITRSGKFGALLTTGIVPSPIKPNTFIVVSLDGKVWKWNFDTQKIQLQNQDVSHSSIEATSALELKEVLENSSAQTSAIKVSGNSSNSHLIAIGKKSGIILIGDLLTGEIISSFRVHPNPVEQIIWISENSLISYSLEKLPDNSFINCSIILDIHTGRQKLFRSDIVNEDDYIKGMRLSPSKKYLAILFNERPFEIWNLITMSRLPTLEHQIIQDLQWRNRNKTRREYFCFSCKGQSIIFQYCVDGSLLKKKKEMPYTSSLGIISHISWINRNFVIVNSSGVIYLFDSSMKKPIPLNAGLKPIIKVISNHQKSEFWTLLVLYSNGETEIYDLEHKTKISSDSKQNHYLSVDIDWMSTTHPILAANDGSIRIFNETRQNCHHNFQLEPKPKLHSPYLLSLENGLRLKIWMKFGLNTHSNTENHPKLLSIDKNTMDPIEKELLSFPDYIVPRKLFSKLQNSDTPTRCMLVEKFYSNKKEEKFWRLALFYLNKYSSDRKNVIKNQEDKIEEKIEEKIEDKTEDKIEDKIEEKIEEKIEEKIEDKIEEKIEEKIEEKIEEKIEDKIEDKTEDKTEDKINLLLSDGIYRNEKSLRNSMKEKAEMTENNRNNRYPLAQKAYQEYVYLNEQNRALETLFYTPHDHPDFFPNLLKSAIISAAISPELFTQTVLRISNSLAEQNRIVEASNILCLTGQTELACDLLQINGFWKEAYFIAKLNLPQDRIQFFLSRHANYLVSQNRHFKAIKIYLTIGYFVEVLKLLKQVQHDDTAGLFLMACQEYNLLQEDSPLVSKTDSKNQNSLTVKEIRQIVNLAMIQYLESLGLTQFSHSYEHHIGAKVFSQKSDKKNVSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPN9</accession>
    <name>A0A9Q0LPN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N(Alpha)-acetyltransferase 15/16 isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="783"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1393"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1332"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1567" mass="184102" checksum="B33062FC6605F2CE" modified="2023-09-13" version="1">MEITIITDIGKKISEKIKSEEKVSNLKNQLSLFTGIPDNKLILYCNSKELLNDSQITKHLKEEEKNLIFCYDADKSKFSSITEYLSKTKRTDFEIKEEKEDTQEDQIPENYLQYYKKFQENKNKLDFHIKNLQTNLSKLEIPNNLILSLQNAYMVTLRHFVGKLEYLKKITKRKSYTDKLAKYQKKFEDLKNCPIISSLLEKNPDKKTLYDYHQDEFNQLVEEFKEKSEEITKIIEENQDNFKELENFINNLKEIWKINIKALYQIDKSQEQVSTVFSTLDASALNYFKSFKSIQATFPHLLFKQLIELQKVQSENKKILFEILNGKEIPHENLPEILSNQNKLISSIEANRMISNVFEKFLVNSEKLSQFIHEKLYQISGKLVEFRKKIKELFVSIGKKVHEEQFLYERIKLVKYFRSSYESFLVELVNRTDIEETFQNGINSFVENFKLELERREYFKNGISSYLPKEFVNMLANNLSFSVIPVQENNPNQISIYLSDIQDVVNPKLLRCLVKDQNQTNEESKSNSLIMDFSDSQEETTISEANSQNNLVESLHLFSNENQKNSNSNSNSINNLKQEENKENDENLNINSIANKMEEKEKEFQQKEENLIKEKAKLEQEIEEYNQEFISKQSTMSNLSEQIQILLKEKEAQKQILKHTEQEKEILKNELEKIKNETSKNSSKRKKKSKSKKKRSNSHKLNSQDSSKKPKEEDHILFILKTGFYSTPDKLVILSSKSARKLRSLEETLPKFVIGKVTSVQNIKISNERNFLNLPVGSFVYEVDCWQIYGILNRQHGNFVEAIKCYKNSLRHEPNNLNIINDLSTVQMQVGDYQGNKESRETLLKAKPTEKRSWISFAIANHLTGDYETAINTLKSYTSLVTSQKKDEKFPHYEKSELALYQNLIIEESGKYQEGLQHLYTIRSFVTDKTIWNEKCVFYLMKLNKLQDAHKIILQLLETNSENMGYLKLLHQSLGIESLENLPEESIKKLNTLFDELSQKHKFSYAIPYYQLLYNKDEEFILRLKKYVIPQLRKGVPSLFQTLKQIYSDEKKAKQIEDIFLGFLKSLSENKNLEDQENGDESKAAFFWITFFLSQHYDYLEDFPKAFEFIDKAINHTPTVLDAYSLKGRIFKHAGDSHKASELLEQARLMDLADRDINTESVKYLLRDSQIEKADEVITLFTRDGSGYSNLKDVQSSWYENELGKAELKLGNIGKALKMFESVSKHYIQISHDKYDFYMFSMRNNTIPNYIRMLRYQEGLFAHHFYRTASKGLIECYLRLFDQPEKYKKIKESESEKNKINENEKDKDNQKDNEKDKDQENIKDEDVTDDVNVEKKKLSKSEKDRQRAKKFQETKKTESDDDPDGLKLMNIEKSLDEALKYVQILEKSADRFIETHLLAFEVYLRKLDFVNAFNALKKAIQLDPNNPRNHLNKFRLILKADESIINEVKKEFKIEDHSSYNQEYLKAFSKSIPHRLVVFKVMLLLGEDKSQAVQMVSQLEDDFIAGNKRKNAICSEVLKEIMLVDEKEAEVYKKKCSEKFIFDLAFKSEVENQEIKENQEIKENKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPT1</accession>
    <name>A0A9Q0LPT1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DENND10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPT1"/>
    <dbReference type="OMA" id="HKDIAMF"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042431">
        <property type="entry name" value="FAM45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28544:SF1">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28544">
        <property type="entry name" value="PROTEIN FAM45A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="336" mass="38563" checksum="8474B0620AB23B44" modified="2023-09-13" version="1">MEALQSISIIELDLQDDLIVSWTYPSISEDLQQIIAQRSLLKEQNTNFQEFSFSKFQSTWIYIYSYAFKKESKSLPEIKAFSIALLAQEFHPEKYKALAKLLSKTYRRKGNPLHILEQYLSVFSQGKWDNFNISSFDRAKALSATSINEIITLFGEDFMLIWCALMMKKNIVVFSHNLDEVLKIIRGLPLFVWHRENFDILRPFVQINNIQLQDLQSTLGWVAGFTDPDIRKQNFYDVFVDLTTKTIEVGERAQGQIVLTEEQKSLGQTIFAAVESGKKSDQAIIKALTRKNKEFISKIKSISGENQLTIETIQKLNLPKPTEIFVLSLASAEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPX2</accession>
    <name>A0A9Q0LPX2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPX2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="280" mass="33070" checksum="4D1E571CB9C26DB1" modified="2023-09-13" version="1">MKEFLQLLHWNQMKRTFKRPMKIFKKGISEYFTQIFIREEADLMNFLDLKNPKHLTVATLFSLAKHFCLRGEEVTNLEVGQLTFEHRENEDFIIYRQGESKNNKVVTHNTNFEPKISKLFRLSDHPKDPYNVIKVYWDYRRRLDTEKSSLFFRAINFNSTNGNLLKNQSIKSQTLLKHFKAVAKKRQEFQKKISKTLFLLIRLDGHKSISSLQIYKRSSIEKEKKVDSLLHLPLEVSQTSDNSHFSNEVTTSKEDLNHSGISSLLIIILFLLLFNFLLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ44</accession>
    <name>A0A9Q0LQ44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger hit domain containing protein 2 protein fon -related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ44"/>
    <dbReference type="OMA" id="WHLWRLL"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="336" mass="39144" checksum="8FCDFCE2CD0A5488" modified="2023-09-13" version="1">MNHKKCSVCRKNIAKYTCPKCSVEYCSTECYKKHSLICTESFYKESIENDLRKSKVNEESQKKALESLQKHSFDLIENIEDPNPNEGEEISEEEMKALKKLVNKEDLSIDDLTKSQKEAFFNALKLGKLNDIEIYEPWWSDSSVKKNDYLIEEIKGEKKEENPKKYDKIVPLSNLIKKEPSPKLKYNLVDILYCYAYIMRMYNGEINDSNKDEVFASISSISGVLGSDQVYSNFDECLDSCLKNTQQSSLIFVSDEYSLMIFKDVVSILKMGKNYVLRAIQELKWFISLIGSKKSQRTSMKLKFFLSWINEQNSLEFFEQIYQSIELILNTIDLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQM4</accession>
    <name>A0A9Q0LQM4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tbc1 domain family member whacked</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQM4"/>
    <dbReference type="OMA" id="QICHKYL"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="96"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="362" mass="43400" checksum="7CE7BC6257B86E96" modified="2023-09-13" version="1">MSDKDFNIESDESLEINETKTNLNSNQETKTTEKFDEYGFLIDEENVQISQKKQKKIKSKEEQEEKKKVKWNQFFKNWNFYFEKKKKKIGKQVIKGIPNSLRKEAWLRLSGSFEMLSNEKYSELYNNCLKKKDPKFQEMIVNDVKRTFSTNRFYKEKDGKEKLIRVLTAIAAYDPQIGYCQGMSSIAGLLLFYMDEKESFLTFLSLLERYHMSGTFRPGFPLILIQMHQWKRSLEKNLPKIHQHFKENEIIPEYYANVWFITLFADLISFDSLLRIWDVFLFEGFPFIFKVGLSYLKIFQKQLLSFSMNEILHKIQNLDEFSIEELINTANSFQIRSEELVEWRDEFFIEHKNISLLFENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR47</accession>
    <name>A0A9Q0LR47_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR47"/>
    <dbReference type="OMA" id="RCEGVNW"/>
    <dbReference type="OrthoDB" id="27234at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="3">
        <location>
            <begin position="329"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="680" mass="78389" checksum="70C3FFF8BB9A3F3F" modified="2023-09-13" version="1">MKLHFQICRDFFFHFVIIITILINVFAPVTYKQTKKIDDFDLGYQVKKEATFGNGTDRLFYFMQVSDTHISKYVSTREKHFSTFCNDFARAFDPSFVIHSGDITDDKANKRGIFMNHPNEEEWETYANTLKQSGFYHQSNWMDIRGNHDASAIIGKYSDNNYYYTYSPWGQYLNSIGRPQVYNSMRHMIFGTYNFIAIDFTTYPQVSAPLGFFGFITKDILDDLEAILVDAEQNHQVNQTILIHHFPFSLLSSQAVKSSKGNSIKDLISKYRIIALLDGHLHSTKAEARILDGKVLDLSLGDMKKHKSFRICAFDEDIFSFIDTDIDHTDPIILITNPKDCRYLSPREPLEKIKYSQNIRALVFSPIGFDSTTIAKATCQIDGNTVSSNMTKISDVPLMYTAPWDPNRYAGETHDIAIHLMDKNGNIITSQSQSFSTTYHPKKIGKGIFEIIQHQNVSTSIIAWMTILYLFYGFGFVILPKILRLVLLKTKSYEKFDHKMNNFCERKAKWWKFPYHQFLSMIWKFGKIPNSIWFIFLWAVLSPLFIPFVLGPMIVHTWGAGFIWGVAIHHSVTFYPMIGFYFILYFLGMIFPALTVVSLPFVDRDLRNFSDFLRNPTAILSACGILAIDGWFIYLLVLGYGAAGLLLSVVFMWNSGILVFLIIYTIKSHSKKKVYEKLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRG3</accession>
    <name>A0A9Q0LRG3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRG3"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="228"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="362" mass="43091" checksum="C4FF872D155F2EF3" modified="2023-09-13" version="1">MLVEFQAKRRLYSCGHNKYNGLGIFDEDTYEFTEIKPSLFENDDILDFSVGFDHTLILTSNSKLIGFGDNTYGQLGNGITEAQLIPIQIELPKLRFNENISNYHVFCGYFKSFLYFPPSSSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNENEKLQEIISKKSIKESNQIFEMIYSNNPKINPKLYFEIKEIINSNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQLLEYWIYSNQIKDEIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFDNQNQNQNQNQNQIQNQNQNQNQKKRKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS95</accession>
    <name>A0A9Q0LS95_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mob kinase activator-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS95"/>
    <dbReference type="OMA" id="WIEIRIN"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="218" mass="25807" checksum="9F0EBE2CEF645C75" modified="2023-09-13" version="1">MDFSKNKKSLTFRPKKRFRKGSKRHQLHQLAKETIHASNLREAVTLPDGESKEDWLAVNIVDFFNQILLIYGSIQQFCTKESCPVMSAGKKYEYLWMDNQKYKKPTKLSAPEYITELLDWVQDLLNNEQIFPTADQFPEDFFSIISQITKRLFRIYAHIYYSHPTELEQLGALGHTNACFKHFMYFVNEFNLIQKRELAPLEELINELFSKEPNQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSA9</accession>
    <name>A0A9Q0LSA9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1297"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1330"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1577"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1673"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1736"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1768"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1506"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1940"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1430"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1463"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1508"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1983" mass="228219" checksum="C1871294AA762856" modified="2023-09-13" version="1">MKNKCSKFWKKVFKWIGKPQFLDFVGDDVIWRTMTILFLASFFIFTFGIAIRYLLEGLDLREDKIATNLAFFKFPNETEVFYGQPISAELRVFKKFKSDGIFDCAVSVRASSFDSVEKESDFSLLELREKIKSDPQLFGGLTQYSDQDGIVKFSDISIISGSSNTVKLTFSSNCNWKNELDLSGPNRKINLGYDSNGSEIEFPVTMKSKIKHFHLLNNDSINKGTFDYGEEILLVMNITNKEEFSDSELEGITFSFVPGNRSLVYAEYEAYAVYELVDYSLDGNGYGNNIIKFLGSTSTKMRFTSFAQGVQLSSEDALGNDVEGYFELNFTTKVKSVGISQNGSLSVKEDEKFSTPWIISVKDENDFPIPNKPVFAKISGFCGVEISEDQQIYVDEKRLENSLVFTDELGNAIFTDLKFSLSGTTYSFCGFQIKFISDGVSVVTDDIQVNSSISKMVWTNQMTKLEIFYTSQMGADSWPVVQVQDELGKGIANKFINFEISNFTFNPSYFQTDQNGFALIHTDIAHMGLVEDYSEQIYDVWIDNYISETFPVNVTNGFVFQDPRRISILNLNSTIRSGEILNLDVIVEDFYGDIIEDDWYVTAFVRPQDVALGYLIIPEEGYWQISNGSGTISTRIFGKAVKTQFCLIVSRYEIPDPNHGECWDCFTLVMTNDVEEVEISYSPDVDNYFIPHQTFGNESIRVKVSGNNLTGTDVTVHVAALNAWDPYFDIFGLNSSYRARNLTNVLFESNYTLDGNNELILDDFVINDQTNYDIDFQHEPFDLVVFVNGIPATSEVFINLKFSNQSLHLNVTWDTSESFTSGNNRVTHQPTMRITDDLGDPVQGYYGYFWVANSGLTWPFDYVHTYDTVYPVVRSVAPSDENGTVTWNLSFQYVRNTQETYAYVYVWQEGYYGNEIVYFNVTEEFPSFEIYQMPDRVFINQDFPTSPTILLYDYYTLQPMMNKYVNLLSWNDSTYHYDYQGYEITNENGVVQFSLNSTGYEDQSFMALIFIVDYKQTGYYWIDLLTFPTHIFIKSQPINGSQIGYPFLFPTETLSVDGSLVMGSVVVQLFAYSNFVEGKILSAEIEENAGNGVLDPETTLSTTGNNGVALFNLKMISGNSGYYTIKFSYKNITMTSDPFYLQNPIDSVTSQVYDFPDDIQIGDKFSATVTVNFNGGYQEGVNFPITIITKCCNVSIPESSISISSEGVAYFQNIQFDSISGTSDCLIQTNKENKVKGEVSFSILGIQSDYHTFLMSSPDSVVLTKAVDSLKQSILFWVVCLSLAVPFFLNSLKKHNIVTFVVALALMIILMCFLPQLIPKAKKVESRQYISLSFFEGVLVSFALLLLFILLLSRIIPKFPIWIERYVFVHERMSSYTSLLKRLLPIGGVRSLKVREIEKTLGKNVAISKTSEDDLKEEKKKEKDQNLNEIELETDSQNENENENENENENENQNENENQNENQNEKPEKKSEDKNRFQLTETEIRLILRRSTRRYGTQNVLGAFSQIQKDEKEEKREKEEKEEKNPSKLKRSWKWIVKQFKKLYKKIKLKFKEKPNPHKEYETYFDFYYPQRLLASFWLWVVLVALLILFCTKLFRSACLSIQLYRQQIIGDLQQSSCFNDRPDISDYPETISVYAIQLINQFSDYCPIDQKPLENSFKNFMYRFSRYQVNKIMNAISVVAGISAFIAFMILLLLWRSIFNLYRKRIMLLRQGKKPFNDFDQAKTVLVTSYTNLQIWLGLISFLFVWIIVFIILFLIPALYWFVSKDFVVKVITVIIIFLAIVFVYQIIFGIVIQKIMNKYFVDKEQITNRTAFSIYDFIKFFMTVFSGATSAVKKLLGTTGGSVSTIFRLDDEKSIDESYSAMMLIDHQTNNPILRVFSNYLMNILKHQKEMIRHIPEKKPDISEKEISMDVSYLENHPITGEPFEIEKIRKKYLFLLTIAANKKIQELRKNVIETEKKRKEFLKQKEDKIWETIKNAKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSI5</accession>
    <name>A0A9Q0LSI5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_06253</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16773">
        <property type="entry name" value="RING-HC_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1219"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1311"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1229"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1317"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5076673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1444" mass="169427" checksum="96B2B30C91FD9A06" modified="2023-09-13" version="1">MDPTSLTYYLSQLGYDRREIRKALRETKSTNVDEIVMYINNSKYDAQKKKDDEEQEKQKQLKLEEEKKQKEQLEKENQEKEQKEKEKKEQEQKERELKEQKKKEEIAKKKLERKKKKKKQSYSDSDDNKEWNDSNSYEYSGNDLSGDSEQENENENENETLKPEDTETPTPYPNDFENDDDGLDVLIAEEKKKIKTSVLTEDELIRKQEKLISKVSEIIDRNYEETRLLLRKNQWNEEKFLSKYFANPQTTCQEAGIKYTGKSTKKKISSFMCGICGEDFEDNPDEMFALDCGHAFCKDCWRNYLNLKIKEAQVGAIPCPGFRCQNKVSSEVIRSIVTEGTFKQYIRFQAHSFVEENPDVKWCPAPGCGRAVHPSQVQFHMVKCDCGHRYCFECQEEPHGPATCQQVEEWKKRINEGKKDTETDSWMNENTKPCPKCKVLIEKNGGCNHMTCYKCHYEFCWICLDPWAGHTSYYTCLAKGTEILIYRNNKIEIEKVENVKNGDLLVGDDETKGTKNQRLVSDVFSHSGKLYQITQSNADPYSVNEHHLLSLRLTKNPQIVLLHNEIFTEFSWMIEYFDPKTHNRKYVLNDVFENEICQMSQEKMQKYWKKQEYFDSDGSFFEKESKELGIKLDAKMLRKLQESFYIVYKELKRMILKGKTAVAGDVIDISVRNYIHKKTNEWKELHKGFQVSGFCEKQTILFDPYSFAFELALSKATNFLPENVVYNSPEIQAKALAGLMDSMAQEEDGEIVFHFSVLDPLVDDVCFLCKSLGLVSKQEHYFDKNQKSSRIQVSISGRKLKEIPIRNFEIKNLKCEEENLQDIEIDEVKYNVIHKESGKKIFAGKNHLLDLVFEPNEAIRYLVGVKDSQKRIRKLQAFSDEKEVEKFVSLKQKMEGNGNYDKNNNKKNFQLKGESFYQQKLEEKEGSLVVITSEKNFPNNLINKTEFSSYIAIEIQEYLKLSTELKSTLKSFYYTKQNGLNCQIRKEKREEIQVQKSINGEGRYYGITVDGDKRFLLKDFTVTHNCNRYEKAKENEAKLKKELNYDREDERRYNHHFDRYQNHSRSLEFENRMLKKVSQDLQRMKPKDPNYRRVTTIRDALDVLIDNRYSLKYSYVFGYYCPRGTVQDLFLFMQTDLEKSTEDLSHSIEHLQKVDTIYLQNLTKLASSRRYALLEILTDIDKDGNMIYIPEQKSTNRTPNQSRWAEDDEKPQIKEEPIVEEIQTRRILPTQPRTRISPTQPRTSPTRISPTQTRTSPTQPRTRITTTTTTRSTATSTESVNPDALERQLLNNITSIFSQQLPRMERLRTQFSDRRNPPPPPQNPPPPPQNPIRPPPNNPFQFQQPPPPPPRQNNPPPPQNVRNPPPPPPPDFFIPEDNNQNPIARFFLQPRFWAILAQDDRFSQYLTDNEFTRKVATIRNNLSTLDSFLDDQRIIRLLETFVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSJ6</accession>
    <name>A0A9Q0LSJ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patterned expression site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="KGVLVHW"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="33"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="747"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1349" mass="158031" checksum="FC557D463722BE7D" modified="2023-09-13" version="1">MEKILEQHLKKTRSVLDTALDEVRKKKLAHEYLTRLQEIKEWIEEILSIDLGSAADLGISLQNGVVLAHLAEKFAPQVVGKIVTFKMLSLKHTDNINYFIEMQKLFKIPDVVFFEVNDLYSLKNVINVVYSVYYTATKLHKKGLAPPVKSLKGKAKFTEEEQKKAIKQLEKADVSKIEQMSQLTKKKTKAEEWIEKYNKEEALPAILIIQSVIKCKFSHIHKKELSQLFNSEEYKKWLLSLQGAFKHQHLQKQHQEHLEFLKENKEEVSKIQEAAKGFIERQKSNQNTNFLKENEEDVSKIQEAAKGFIARQKTLDVNNFYKENEEDVSKIQEAAKGFIARQKSLETTNFYKENEEDENEEDVSKIQEAAKGFIARQKSNQNTNFLKENEEDVSKIQEAAKGFIARQKSNQNTNFLKENEEDVSKIQEAAKGFIARQKSNETIDSFKKNEEEIAKIQQIVKGFMERKKFQEISKMGKEEYDGNNGFGNDFGEDDFEIDDFEDNENENTEKTDGLDPQRRGRKKMSPRLLGVLTIQKHVKRMLIQREMRRRRRFFRSQKKPISKIQAFRKQYLAHQHFKRQRKSAVKIQKTFRGFKSREMKRSLAGQNEMTLETMANILRMFRVRSGMIYDNEKMTNDEKIKTTQEEDLTKLREDWVKEIRQNNDLQHEVQRVDKKISLLVKNRISIQEIDSQSSKRKKQDESKENMIPSQYIEIYQHLFYLLQTEPKYLAKTLFYIQPNELEGFVQTMILTLYGYAFSPREEYLLLRLFTLSIGEQIFKQKKASEFTKDDPIITKMFVFYFRRVQYQTFLKELLEPVVEKVLKQEDLVIELNTTRMYQAMINKEETRTGQKSDLPRTANHEDAIKHQAISELYEKNINELSEICRHFVNQISKSIHTIPYGIRFICKAVRRSILEKFPDTNEDEISRIIGYIIYYRYLLPAIVQPDTFGVVAPDFNISLTARQNLALISKMMQSVATHKLFEKNEPYMIPLNNLIEELSLKSFDYFKEIPNVLELEEQLQITSDYDLTQQKMPTIFVSPKEIFYTHQILKKFLSKIAPEKNDPLRIILDDLKDVKIPSKPSEMEIQLMLINKFQTDAIKDTETQTIYNDTKKLIKDLLTSAPPDLLRSNSNLIELIFNDDLTQNSLQDILVPLRKNITFLEEKGVLNKADNFKNLIKEIVHEIRNASKLYRQNQVEIARLKKNLSIVRQSKQYLIEQMKQYNDYLDSVRKKQYELSVQKMNKKNLKKKKSEYICGPVSKKYKALAKANIIISSDIPKATWGATSFVFTSKQTGIFDIQAKFAGASVEKITINVEDLLEFQSSGKSEYPVERLTLNVNLLIHFLNKMMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSP9</accession>
    <name>A0A9Q0LSP9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSP9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040321260" description="Fibronectin type-III domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="100785" checksum="4221ACDC834C2E37" modified="2023-09-13" version="1">MKSNQFFFFSFFFFLIINIFLIQSNQNNQKSISSSIIPSSIIQEIETTRLLTETTRYYSTPDEAWIWNLLDQFSGSGWFGWSVSIYEDVIVIGTYTAKQAFIYRYNGTNWNQEQILIESVSYFGYSVSIYEDVIVIGTYGANQAFIYRYNGTDFYEDVIVIGANNAKQAFIYRYNGTNWNQEQILSESASYFGYSVSIYEDVIVIGAYGAKQAFIYRYNGTNWIQEQILSEPSASYFGYSVSIYEDVIVIGTNFANQAFIYRYNGTNWNQEQILSESATYFGFSVSIYEDVIVIGAYYANQVFIYRYNGTNWNKEQNLNGLSYSYFGFSVSIYENFTAIGAPLANQAFVYEANLIPQVNILNCSSLFSSFDCYWNKIEFPSTLKYQINYGYDWIDIDSSILEDENVYYQLFNSSFYDNITGNEYYSIQIRTCDNATMKCGESSSFINLTTKIDSVKDFQLSNPSNYSINVTWNYPNVQINEGIAHLNHYNLSYLNQSQPDLISFISVDNSSLYYLWNNFECENDYNISICGCRTQECEVDDKGEIVESSISLIFGEITNISCSISNLVDINCTWNQSINCSIPFYYNFTYQSIYQNDSGNYQPTSSNQQFTAQFPNQEYQINISSCNSNDKCGYISSISIKTDNLSSPIIYETISKIEEIEFNFTKLINAKNYSISLDNKTNWQKFTSLDLSENEIIGIISGISGNVEYNISIRGCIDLNCETPYLGLPSSIISTKAKLGNISSLNCNSLINGFVCTWNPLILSNGLKGYSFTYNSTSEKNIMKFQFIQSSDLNCSFNEYSGINSTTSITTLSPYEPCEPCQKTDNSTKTTTITIGIIIPIIDSTLSFRWRFPIQLTHLALNHLSSGFGMCPGVFDWIWPNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTE6</accession>
    <name>A0A9Q0LTE6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTE6"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="272"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="325"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="494"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="599" mass="69916" checksum="CAA17F9239A1C0E2" modified="2023-09-13" version="1">MNEILFFGQNFYPNLFKNEPDSITKPIQFKFENENENENENEKQIKQISTGFFSIVFLFENGKAIEYLNEEEYLKYSNQNLEKIQIEENIQKVTVGYYNEAILTKEGNVFAKGYNINPKNPKEFINISSLIEDTNDRIIQDIVSGYGTIYLLTSNQNAYGIGSNQYGQLGFDSETLKKTEKPILMMKNISKIFSGNCSDHVFLLNSNQELFGCGSNYDGQLGLGKSRKQEKKIQKLTKIQNIPEGKIIDIKCANFHSIMLTENENENENPKRKFYSCGNYQYNGLGKNKNTYEFTEIKSSLFEKDDNILDFSCGQEHTLILTSNSKLIGFGDNLYGELGTGDTVEQLIPIQIELPKLRFNENISNYHVSCGNAQSFLYYSPPSFSNLEEDLIKLFQRKEFCNISFKTKNEEIIEAHKLILKYRLNQNQNQISKLQEIISNKSIKESNQIFEMIYSNNSKINLKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITKEIINEIEIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTF1</accession>
    <name>A0A9Q0LTF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTF1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="67" mass="8287" checksum="9277A55BEA663A02" modified="2023-09-13" version="1">MLKEIKSRKIKKDKDYEKRNRIKTKKQKIAENDKDKAAMIKEKEKKDEKKKKKKKKDKRLKTKNDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTJ5</accession>
    <name>A0A9Q0LTJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_04776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="329"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="414"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1167"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1358"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="1903"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="8">
        <location>
            <begin position="2324"/>
            <end position="2517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1442"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2031"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2252"/>
            <end position="2284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1442"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1462"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2037"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2252"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2270"/>
            <end position="2279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5078451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2712" mass="319964" checksum="138EF955E27AA9B3" modified="2023-09-13" version="1">MAFSSIALFDYLAQFKNILNFQRGEIIEIEKIENGWNFGISTKSKQKGKFPENFTFPINNLNPQKEILTSIQKTQNSKIISSQTLRINEMKINANIEKFSPTNPEIFSSNFGIPEKYRTLEEPKEKIKRLFLKFDEQQTDIDLEALFDKKAVVNLLENETLNHKKGFLILENNTLSFYNTTDFNQTQDISTKIFSINFNNPLSFYPYISDPVIPSTLEIAANQQKYFLQFENQLELESWNSTLKLIQVFQNLPKRKLDYYDKDLLKTLLEFLEQLKIQTLKQKQDEKNDHFLNQNVELIIFRHKLQTIQKWEQFILHNLFLIHQDLYSSPRQFLLVVENFMPRNEKELQLQKFDLINLLEAYQDTYWFGENNGKVGWFPINNTVLLIPDKIVIDDKNQNENLIQNSNCDLQDLEIKFQNNLLLYNSRSKQDVWKQKWAQISQNHFFIYNSKYDSIPEISYKLSELKSVKKIDSQENDPFSFSVYIQDSMNTFGVVEQNLLDEWIQIMRLVMNWNMINNSHISSPDINSSLNYEKMTNELVFWIEQKRADILGFAEETRIKLHKKLFELNRILIGSNPKSKSKLKSNSNFSIKSEEQKEIEEEKDTRTKSLAEFNIQNKKKTPLKNRKLNSRGLSFVESPKNTRMNLNDKIHQQRFSSKYKTNHGAPQILSKATTQYEFQHIKMDQFPSQDPEIEFNNKQNKYQNIITQLKQNLSVFENEISSLNRLRSQLLNLYVITHFPNNEAEEMGYSISPYLSLKFKPFPHIPFGFGEWICDIKPYDSHFLQGCVGKITGLIPRNRCEIIPLHFANELRRKNSGNIPQSQADKVIALQITTGKAEKLFNDFADYEKKNEFFPPIQKNGLLETQIATIKSRERKIINKKFWVFLKGWFFGVFQQSNKNKPVFGIDLRKVVQISQLVDKENPGKYTIKIREKGVSESRFFFSTENYEEFIEWMDALLISHLFYQLSQAPQTLEDKKKHTLATMSIVEFLDSFKLEMENQNSSFILMDNIGKFRLFLMNMDAQSNMKKEDDLHKMVLAWKSYQPLKRNQLSFKRGDWMTLVRKPQGGIMKVHFHGKVGDVPEKNVEMVTMDDQEQEISDLHDVSQREFECIARPQVIEEFSKSRSSKSAVFESNTFILPPNQKKPKIPSFEFSGIQAKLPIFLEDEVYLRRGLFNEIPSQNRDVWKLRWMMINSWTLYLFRNKRDSMVESGAEFILHLSEFADVENHAEVQNGKYFFRILDKQKKVWFFGADSHTKIKQWMNACEIAQNLYTLLISPFSQQKREEKDFHEQYIKAISWLQREIALESDLQLRLMANQSLGVAHKKEIQKTHYWLKNLQDWRKMCLSRVCRLLITSQFDFNKRVFCLENYNAKNQNELAFSQNEFLVLIKMQSSESWLCKNLEGKTGLIPSNKVEIVLPSSPMSFIRESPNSTQDSQLKLKFSKEQSRIQHQEKQNPKEKFSSPKNNLNQSKISSNRKKDPKTSQDSPHLNLSKKDLLISSNINLIQQQKESQNTNIQSNQQLPQILKNQPANLLRQPLIEKVVHYLDDEYHNNLNEIDQNQAVEFALNFLRKWNIDKHDDIMNFPVYHQGNLHEFVENSWIRWWVKTLMIIIIIINLFSKIFRINKYLKIQKNLLNYPESIQNTFSNSNQPPNPQNSNPFSSDLTTNFLFQISFLISQTYFAVENNDELNKWLNKINKISEFTNFFQIPKIFSNENGNEKQSALDTLFNLYQWSETEIIREKEEKIGYQNLLQFYENYDDYSYISTKKKINFSSSKIRNHKRWRNLILSKICWILFSNLSNFDKMIFGFSFRENLQQTKNTKKLKYQKYQWFVIDSQYTNILNREHQLILATNLTNNENGFIDPKNMRIIKKMELDKQSTQIYSFLSNKVQPTVFHFHIIKPPINKTGTLFVLQSKRFTSSKWKKYWAKINGSDLEFYNDINDVRSVKTIKMDEIDEIRLLNEEEKSLLEKYIVLLPKTAQGNLFHLKNDSKTWIISTFSREVAQKWVDSFNILKTFQLLIGDPINNPISKIGDLSQNQNQNQNQNQNQNQNQNQNQNQNQKNIIQNSKRLAKFQLDLQDARDWLESQMDICLNQIDSLRKIYLQTHDHQIDLQKQQSIQNQFSKFQSNIKLYEIWELITLSNLLRIHIANDSDNNPRAYVPSKYLQLLSTMNLIQEKDSDSNFKKNESIPSFNQPKDQWFNIEIPKNHDEIVNGKILVEKNGKYYYIDSSNVKIVFPSRITLQAIQITKSKSKGKSKSKSKSKSKMENENENENENENENQNQNQNQLKILNNEEKAQFMELLFIQNINFPLIILEEIGSFNSETLCKDMIIIFAYHKKPLISLIEELVRKEVNSTTNISCLFRGKSESSKILSEMAKMFGRFHLKKSIGKTIQEIMDCNSAFEIYPEDGIQNDMNRENLIKIRDYSEELLHNIFSSISYMPVIYRIVCQILSEITFKKFPDEKTKYVVLSGFVFLRFICPSIVTPEQFGITNTTPTSTNRRALVLISKVIQSIANRAMFPEGSTMESLNDVVDSFIPQTKKFMERLLEPINIVQMKPNLSQESIPNFQPNEQVICLLKNYEEKKLICKKEINLQNMIDFEKRECLFSDVDFSTEKVLDQNVQFFPYFETLNIDENIYYDALNHIYNLFMNIKYRNDIFARIVSDYSSLENWDEIMEKMIIMLINLSILSENEKDGYFEGFEKDEQEDEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTP2</accession>
    <name>A0A9Q0LTP2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTP2"/>
    <dbReference type="OrthoDB" id="10588867at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="750"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1246" mass="143478" checksum="7AD71E1FA6D8C785" modified="2023-09-13" version="1">MESGVKRKNLASVQRYVKESKEYLEKNGDVFEKNEKGQKFKSRKTKEILRQANGALGWSQSALKRKEPEKALKYWTECKEKAQPLLSEPKFEAIPDVKKFLDEFHEFEKTIEGDAESQVKQKELETDKKKIENTFYWIKNCYTKKEAENSLKKAADFQSDWEQFMQKYGDEQSLAGFIKDTQDILDKIHEEAPKWIEDKEVEKVIHGCKSQLSWLNSALQRKEAEKASNYRQKLEEAAIPLRSQFGENKMAQEFIEKEVDPILEKVEAELGVIIEDQEVDKIIQKCTSIKSWLQSTLSRSEAQKASEYRKQLEEAVIPLREAHADHEKAKKFLDETDKLLEEVEKQLGVIIKQLEIKQYSQPINGIMSWLESAIKQKNVDNVVKYREQLVQAANPLRRYEEESDVKNTLSKVDALLQRLETELGELITEKEVNRLLPGVKSTFSWLESAFKQKSVAKVQIYQKQLEEKLNPLQEFSQHKDAEEWITKSQALIKQVEDSMGELIAEMEINEQKTRVESAIRFFEDAMNKSDVNAIVRKREALLTVIAPLREKYGSHNLAQPLLTKADTALHRCETDLGEVIANEKAKEISGKIMPLSNLLKQAFAQNDNSAACAYVLKIQKLVHPLRVEYPTVNAVMKLTSEIDSSNNQIQVKLSSYQEKDLHKYLDPITEALNQTGAFKVPRDLTPFITKSLPLRQNYIHIQNVRDTLVKFDTICLKMIGRVPEPVEEYAPIFEVHWKLPQQVQTALKGINETSKQINSLMDEAKNSIEEVSTTGETQMHRNLADQFVDHYDKVSSHITRLERELEKLESADPEHAGIALVKESIAKLRQILPQKKNEAVEKCNYAFSVASIYGPCVAGGAGVVENAIESSDAKNCSISFDNVLMRSNAFMWGGPRLSGMSHSSMWPTVISWFEYTKGKAEEVKRMRPDNHPEVDMIIKQLDASFITAQNHFLETTKKWAVLYYKDGSYESGDRFISEYEKVYPNTGYLDDIKKQCVAIKQEVEDRRRREEEERKRKAEEERMRKVNLAIELEKKFKEPFDDGVIQTPDSGKWKYTKDGTLTCLDGAYIGLSFKLQRSERSGTLDLVSETGAHGWGEFNGTDFYWGHQLGWPLHLKFDTEEYPHRLNWEKFDTVKKLVEATQSSGNVPPFCVVWCAMFHASQKYIQRYKEAEQERLQKEREEKQRKDTLNNLISKFGSCKRCHTSGANIRCCPDCHYVFCTNCSNSGRGVNVCPSCGEYHCETHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTU6</accession>
    <name>A0A9Q0LTU6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA n6-adenosine threonylcarbamoyltransferase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTU6"/>
    <dbReference type="OMA" id="KRAMAHC"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gcp-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="137" mass="15565" checksum="6C9AE21E46C90BBF" modified="2023-09-13" version="1">MDVSFSGILSYIESNGLELLQKGECTVEDLCFSLQETIFAMLVEITERAMAHCQKNEVLIVGGVGSNVRLQEMIKLMVEERSGKIFSMDERYCIDNGAMIGYTGILMYLNGARENVENTFVTQRFRTDEVDANWRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUF2</accession>
    <name>A0A9Q0LUF2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUF2"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="1">
        <location>
            <begin position="147"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="743" mass="87767" checksum="3164D18EB8D98831" modified="2023-09-13" version="1">MEQQKIQKEKEFKINSKINQVQFFQDLQYLDQVKKKVLVQLNSNYELEKQVINYDHQISHLLQKQISTAQEGLKTQTQNENISIEKEITKKIIDEQKYVDFIFLLYYKPIYISKIIHTIPGIQSPKFLEIVMNSIYEDQESQNTDILLSSTFNLSLHEEFKKNQYLNTILRSNSTLSKILTRYTRRNSGINYLKEVLSDFIQSIATNEEQNLEINPIKIYEEIYNENQGNNSDMKDPKEISYGECENFKEITNRSKKRLIQLQKFFEQLVDNIFQSVEKIPKGIRLICKRIRDFSQEFLTEINEFSLTALVGGFFILRFINPAIVGAKSLDIIEKDVNSDCKRTSVLLAKMLQNLSNMVDIFEDKEKYMTVFRDIILSKRNDLISFINSICKVEEYEIDEEIIQFNDLLSGAPEISIRINDIYFLHELFSKNIDEIGLDLNDPLKNLLNSLGSVQTQIPAEQNYLMKIPLKKSITSTIGHRKSSYFVIYKDTLLNLTTIYHEIQKKTTKNEILKYEKFIKILNQIRQEAKNFHNLKMNNKIKHLLSNIKILIRERVILPENDFQKLHFDVQDILSNIKETHSKIFEEINLLEKVHSYLLLQRKPLQTKKDSYPQYLANINVELQTKPTLVNRSKSMKMNPKSRVLKKQFFEKTHEELEKSGVLVSSAIPEERQEFVYFVFRKTEKTGIYLLDVMVQQKKEPLETLTLLMRDLLQDRLNSKKNFDLEYLKLDVEKMIKLLEEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUQ8</accession>
    <name>A0A9Q0LUQ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUQ8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="81" mass="9297" checksum="A3B606564C8F2893" modified="2023-09-13" version="1">MNEIIFFGFFSTIFLFENGKAIEYLNENDSKQKIEKIQIENIQKVTVGFGNEAILTIEGNVFAKGKEVNPKTQMNLSIFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUT6</accession>
    <name>A0A9Q0LUT6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUT6"/>
    <dbReference type="OMA" id="VHWPSEG"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="312" mass="36312" checksum="0ACBDF29F4226818" modified="2023-09-13" version="1">MEYIELNTKQKIPALGIGTYRSPKGEVGKAIKIALETGFRHIDCAYFYGNEDEIGEILKETFDQGKIKREDVWITSKLWNIFHDPKDVQEGCEKTIKDLQCGYLDLFLIHWPVCFEKRNDLDLLPRKDENTMSTVDIPLIETWHAMEKLVEIGLVKSIGISNFTKERIEEIYEKAKIKPVINQIENHPYLQQEELCEYCRKNGIQITAYSPLGTSHFKKENPSLLQDPIILEIAKKHNVSPAQILIKWQIQRGNTVIPKAVKPEHIKDNFECLKVKLTEEDMKQIATLDRHFRFVNPLNFWNIDVYGEANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUV7</accession>
    <name>A0A9Q0LUV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">M18 family aminopeptidase 1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUV7"/>
    <dbReference type="OMA" id="DWPIAKI"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002600">
        <property type="entry name" value="PRK02256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF2">
        <property type="entry name" value="M18 FAMILY AMINOPEPTIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="477" mass="53723" checksum="EA00C30B46768C39" modified="2023-09-13" version="1">MEKNQEITEKDLKSKLFWEKKNGYEEIDEKSLNEIFEFAEEFKKFLDSSKTERECINTIEEISEKSGFVEISKASKTDKNIFCQFDRVCGALIYLKDPQKLEDGFLIVGSHIDSPRLDLKQMPIYETLDMGYAKTHYYGGIKKYQWVTRPLALHGVVILQTGEVKKIVIGENLNDPVFTINDLLPHLAANQMEKKGNKVIEGENLNILIGSIPLNLKKDTNSIKLNILNILHEKYGIVEEDFISSELQLVPAGLSRDVGLDRSFVGGYGQDDRVCSFCGMKAFLDLTLNHQDLISKNIMMLFFDKEEIGSQGNSGANSNLVKRIFSQILEIHGKKEYNSLLQTLTNSQLLSADVEGGIEPEWKNLWEERNGSKIGYGVSLSKYTGSRGKSGCNEAHAEFVSRIRKVFNENGVHYQPSELGKIDQGGGGTISKYLANLGMQVCDCGTPILSMHSPFEVSSKADIFHTFKAFQAFFQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVF4</accession>
    <name>A0A9Q0LVF4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol 5-phosphate 4-kinase isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVF4"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="254"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="605" mass="70997" checksum="852606A8EF3F4A3E" modified="2023-09-13" version="1">MNQNQSFQNKHELSPFLLNIDLNEDFSKYNPKLEENQNQNTNSNININSNSNQTQNQEKNQQIIFAQVARKIYKEIFNSILLDTSKITEILIDEQFLFLMENEKTQFKMQRLINDLPTLGKLFEQNILLRKDQMKFHKLVQREIDGILKIGMNKENVSQFLEIAEELHSSKLRINEELNYIYDFIDEIISNHIPENKYSISQNSQNLQNSIYDKISQTQFISDNLGKSFINSIAFQGSLTAGKSTSKFLSKIKFQNFLKIGLITGIEETGKILKLMEKRKKEDFKKINLNQKSVKIKIEKESYHFFNEKNEYLPDYINFKEYHPFYFHQIRFNHHINYYKFMEGLCGDGKLPKHMQTGAGRSGALFFLSTNQAFVIKNISKPDSKILRRLTNLYFQHLKKNPESLLPGIYGHYKIEFGNSCEYFMIMNNVFQTNLEIDEKYDLKGSTVKRGGKSKTKVPEAVYKDNDLVDFIYLGEATKKKIISQIREDITFLQKQNIMDYSLLVGISFIDNKKIQDLQSQVSLFQQNHFLKSFFGGIRAISVDENGRECVYFLGLIDILQEYTITKKVERSLKAVRYLTVNQMSSINPKSYLKRFLKMVERRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVN1</accession>
    <name>A0A9Q0LVN1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molting protein mlt-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVN1"/>
    <dbReference type="OMA" id="SANDNCA"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="491" mass="54920" checksum="FB66C62C4971C5CB" modified="2023-09-13" version="1">MELNNLFKAIKENKKEVIEEFIASKKDINKVDENKNTVFHICAKTGNIENFKLLYNSNADLNIHNFLNKTPLDIAKENNHLEIVSFIQSINRNLKKELSQQFSKEENIERKFTDLHKAILTGEIKKAKELIIEGKIDKEYPAKNGETPLMMASQSESDEIVELLLTYPEVNINRTSDNGRTALHFASSSNRLKSLKMLVDSGGDINIQSLNGETCLHLSAFNGQVDTTKFLLEKGANPFLKSFDQHTPLDLAIINRHQKLIHFLRLNGCPTKLNKSNLATECLDLLQSIKIFRAVLDNNPQELINLIEKNTPINITKEGFSLLHIAANQGFSTILSVLLSYGANFNQDTPNGLTALHLASSKGHVKCVQLLIKFGSEINKQNKEGFTALHLACLNGHAKCAEELLNSKADTTIETYKGMTAFTFCVFTWQRECISILIKKKVNVNHKPKKGLSALQLSAFLGKEEICIFLLQNGATLIGLKPTAHELAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVW3</accession>
    <name>A0A9Q0LVW3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurofilament triplet m protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVW3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="788" mass="95950" checksum="03DE16180F3A5FD7" modified="2023-09-13" version="1">MKIVVYFDPEITKLLITDLNLIQFYFKIQTKQRNRKHKVITKTVVEKQEMKHFPFTNILFSDFDVSKYFKEKEKEKEKEIIFSFIQEKEKEKEKEKEKEKEKQKEKEKEKEKEMEEKILSEKINLKSNFHFTIFENQNKQNNSKINTNDVISDFLNFLFISLFYQNDSNNNNNNIDSNTDTKNDLLIFGESLQIISHVCKSQIYEWLLFPFISNFSETNPISIKEKFALLCLNQHTMRDNYFFTRLLYKPQSLIFQLIDLIITFFENAEKDPNSVFLKNSLKNTLLFQLEIKTPEPIILQYYPVFKRLSFNFFDEFDKKKYSEKLVKQKFYDSILDDYIKEQYCIDFLDFSPKYFEGFKCFLQCFNLWNQFWKKINSWNKEENEENEKFIKSLEESIKKNVENQNFWQKDPKKSLELIIESEKEKEKEKFENVILDILTERSQYYYDNTEKEKIIIDDNIIKNIPLLIQINSWEKFVGENPSKFIEFYESKDRKIQTIWVLTLSWFKKIIKFKKEKENENPKFLENLQKYDKEILEHFNHFNNKKCTFEELLHFLSKKEDYIQFSKYTFKQLFENKVHIAKIENFLKQRFIELNESQIFQNIIKNFIDSRIKELQEKEKKEEIISFTSFRDTIIPSANKKWNKLAKDIFDKEIILSKIDKIFPIENDESFIKKELNFLRNQDFNIKSKEKEKKEYSEENANELLLLIQKYREFQNEFSKIDSNIKIFFEKFKFINENNSKFFDKTWQNSQKIKEIPTLKTILDCFKPNPKNSFSTMIITSNHLIDYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW83</accession>
    <name>A0A9Q0LW83_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW83"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="27905" checksum="B8BFF5BDE2BDC7AD" modified="2023-09-13" version="1">MNNGNKENQLNNKEISDLLLFFQNLHLKTQKKQIEKQFIIQNEENSFQDEKIQNEELLENLSLLEKNYFETRTKEKFSEELSTYLLKYLGLKNQNEQEIKKQKKNLKQEKNQVQKLDEKIIMLEKDLIKIQDRNQQILLKTFQTIQENKKLYQEIVKKKQKKNQFGKNEMIPDNFLSQENKEEREKEKQEIEKLKAYRNGLENIFKNLIIESGIDWSKIPSLKKIILNKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY62</accession>
    <name>A0A9Q0LY62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nf-e2 inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000001">
        <property type="protein sequence ID" value="KAJ5080794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY62"/>
    <dbReference type="OMA" id="FNCKFDS"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="528" mass="62290" checksum="3055B85CC12299E3" modified="2023-09-13" version="1">MDFYYLKRTRFLKQEKNIVLQNQNGPCPLVAIINALHLNGQIPIPLNLEIISHSQLLSLLTNFLLANNRPFKNENLRINQEKILADIMELMPSLGFGLDVNVKFTSVTSFEYTVGCSLFDMLNIRLVHGWLADPDDPQSHKVISPLSYNQMVDIKLKKDLLISNSKSENLSQIIQEKEKEFKEKEKEKEKGIQEIKEKEREKPKFNVDLDFDESSDSEDTNIIQNQPKIEEQNKEQEFTKEIEEQNKEEEFAKKIQEQLRNFQNEKTKKQTQKEREEAFKDMTEEQKNQIIYEGKIIEKFLEDNPSQLTFYGITQLHSKLKDHEIAVLFRNNHFMTIFKYKFHLFSLLTDEGYKDSPHIVWESLTTVGGDNDFYNHRFHVSRNLSNQNLNQNLNQKLNQKSNQKSNQNSNQKSNQNSNQNSNQIEKDRQLALKLLREQQQEEQIQQRQLAALQNQAFDSDIVYDNPMLYQNQHVNQQRFYNSPNEMYQAQALQHQQLMQERLAREQINPPRVRQRRKVPTKKGGCNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R423</accession>
    <name>A0A9Q0R423_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_03630</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R423"/>
    <dbReference type="OMA" id="ENCYNIQ"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="216"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5066297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="385" mass="46329" checksum="975338551642D5EC" modified="2023-09-13" version="1">MISKWCCIIGKEIEQNEKDWKKCIKKNEKYFIEEIPVVVKIKLNPKTISKENEEKDEELWVSKEGYEKNQKILIEILEKLEINENKNQNENQNENKNENQNENENQNQNKNQNQNEDENQNQNQNQNQNQNQNENQNENQNENQNQNQNKNQNKNQNQNQNQNENQNENQNENENENENENENENENENQNENQNENENEDEDEDEDEDEDPNYQCNICLQTATDPVVSKCGHLFCWECLYLWLQQKQECPLCKNPINSKEDVIPLYGRGKEKDSHRFNTQDIPKRPSGKRSAFNFSQARRRRNHNQNVFGNFDLQFGFGPFGTGFTFTNFGNNENQNEENQNEENLTEEERRKRRNQKRILRVIFFLFIFILFFSNFLEFRYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4R9</accession>
    <name>A0A9Q0R4R9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylyl cyclase-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4R9"/>
    <dbReference type="OMA" id="SCKSGDM"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="161" mass="18011" checksum="4EB021A3D3333DE4" modified="2023-09-13" version="1">MTAVCGFDGDKTWKAGYQKDNQQIIFEVKNIKESVSIYKCENCVIQIKGKTTNITVSECKNTGVVFENSITGLSIVRCNKCQFQATGVCSMFTIDNSEACTMFVTREQYKSIEFVSSKSSEIHIIVPGPTEDSDPMEFTIPAQFTTKFEGNTFKTKPVEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4T6</accession>
    <name>A0A9Q0R4T6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4T6"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="161" mass="19206" checksum="0315E806B83DEB83" modified="2023-09-13" version="1">MDNNNNNQIQNANQNENENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENFIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5P9</accession>
    <name>A0A9Q0R5P9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5P9"/>
    <dbReference type="OMA" id="AGFWFFG"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040111055" description="Phosphate transporter" evidence="9">
        <location>
            <begin position="20"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="603" mass="67318" checksum="E1AE9D0D6EFD8DBC" modified="2023-09-13" version="1">MGVLLFFLIFGAICCFLMAFGIGMNNAANSVGTAVGSKAISAKKALLIGSFFEFCGAVLIGSFVSQTIRKGIITTTDFIGNEKEFSLGMLSSLLGSTLWLVLATYWALPVSTTHSIVGGILGFAMYVYGPKVVNTKSLINIVLSWVISPVSGFVVSWAMYTLVKKTILNKKTNEQSFKAAKLWTPIHFGFTISTMVLFFLESGSKWFNFKFAIWIMVLIFFLSWILAWFICYKWILKIYLRKALKPKEFDIDVDAHKMNHQIGVFDSFGIIDLNLEEYQDHGFIKDERAAEEFKFIIEPEKLTEIPVDDKNWKILTEDEFITEFSESIPDKEAEIKLEEFELQELKTDEDQNTDQNENNKDNNKDNKKEVRFENQTESNIDDDDDFDSNDELNLMKQIERKRKQKQIKEGKDPNEPVISPYKAEIEKLGGTVPLFMLLQVITAMFVAFGHGGNDTPNATAPFGSIYSVYTSGDVTKVQVSFWVLAIGGFALALGLLIFGHRVLITVGEKITLLTPTGGYISQLSTALTTVVCSRLGMPISTTHILIGAVLGYGVSLYGWSTGINGKMIFKIVVSWLVTLPISSITAIMIFAVLRPLCGNFSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5S8</accession>
    <name>A0A9Q0R5S8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation/h exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_12386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5S8"/>
    <dbReference type="OMA" id="VHGINIF"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="363"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="620"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="572"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5068274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="775" mass="88290" checksum="A0EED79F24E6649B" modified="2023-09-13" version="1">MNLKSDLQLSLLDNQQDNELIIENENENENENQNQNENQNENENQNEIELEIENQNQNQNQNQNENENELIIENQNEIELEIENQNQNQNQNQNNNNNQIIHTSDSSEKDISSKEENIPKISLKNRQEHLNALFGFKPWSSGIIQRKSPQKIPEMNNFLDNSVENSNENRKKKTSLISFGNILWVILFGWWLALIYLILSLIMLLTFFGKKYSKKLFILSGYIIWPFGKFLIKSNQSKSSIIDKIGKFFWYIIPAPLLAIIHTISFLLNYFFIFFIPMGKFNMTLFKELMKNPELIQVSKILTSNPRFETKPILFTIRAVNKHYYKYSINGVNILLVDLIPIVVISILFGLLIPEDKPLGNPLLVFFLCLLSTIPCAYFIGLAISSLSAQSTFAVGAVLNATFGSIVELILYYFSVKKNLLKMVRSAVTGSLMGTMLLLPGLSMVISGMKFKEQSFNTISAGVSSVLLLISVIGGFVPTVYYQVYAKYQLSCGSCISQNPLDCQECTYKEHDLDNDYNYTHSAKPLMYVCACVLPLAYILGLVYTLKTHAHIYDQQYFVNREEERKNLKILQKKRSKNSKNQKNEENQEKIKENQENQENQKIHKKKAEHDAPEWSRLKSIIVLLIATVIFATVAEILSKKIEPSLKKLGLSENFVGLTFIALIPNTAEFVNAIQFALQNNISLSIEIGSSAAIQIGLIQIPVLVLFTALTSSGHASTSYTLIFSNLDVFCVIFAVLILNYMSNRGRANYFEGIALVFIYALFLSAFYFVPDNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6A6</accession>
    <name>A0A9Q0R6A6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_12667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6A6"/>
    <dbReference type="OMA" id="NVTRGFN"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5068081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="378" mass="45561" checksum="61F408F046EAA763" modified="2023-09-13" version="1">MIEFNQNLKKPRTEEEIQKENQDKTQNLKIYYDYFFPFQQIFEWLSYGNLDFFHFREFSFLSSNIIRRFVSFENVTEFQRYVSMNIPQKIDYGAIYNYPPNKRNEITEFQPKKKELIFDIDITDYDDCRTCCSGTNICNKCWIFLVVAIKTLEYILRNQFAFRNILWVFSGRRGVHCWVCDKTVLDSSDSLRKNIVNFIFFENDEKKPLTPNQLEIYNEILEPYFKKVIETQELFEKPENWQKVLKFVKEEEIQKKIEKDFEQLPDSKSRYEYLQTMDYSKILPQIIFGVIYPRLDINVSKTMNHLLKSPFCIHPSTQQVCVPIDPQKCEDFDLKLVPQLNNLVDEFNEKGINSIPQSKFLNYYIKKLFIQDFLDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6H7</accession>
    <name>A0A9Q0R6H7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6H7"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="310"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="475"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="408"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="588" mass="68951" checksum="84EAAF821256B3C3" modified="2023-09-13" version="1">MNEIIFFGDNQYLNIFKNKPNIIKKPIQFKFENENEKQIKQISSSFFSTIFLFENRKVIEYLPFSKRNPQKIQIEENIQKVTVGNQNEAILTIEGNVFAKGYYINPNNPKEFINISSLIEDTNDRIIQDIVSGDSSIYLLTSNQNAYGIGSNEYGQLGFDSKTLEKTEKPILMMKNVSKIFSGDTSNHVFLLNSNQELFGCGNNQYSQLGLRESIKETKIQKLTKIQNIPKGKIIDIQCGYCHSIMLIENENENPKRKLYSCGRYLFNGLGKKEDTYEFTEIKSSLFENDDDILDISVGSFHTLILTTKGKLIGFGNNDSGELGIGDTEKQLIPIQIELPKLRFNESISNYHVYCGNYNSFLYYSPPFSNLEEDLIKLFRRKEFCDISFKTENEERIEAHKLILKYRLNQNENQIENLQEIISNKSIKESNQIFEMIYSNRIINQKLYSEIKEIINSNEKIEETIKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQEIINEIVRAIDYFQLNQTNPNLFDLLINKFNNQKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R700</accession>
    <name>A0A9Q0R700_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_12123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R700"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5068951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="456" mass="53005" checksum="BBA6B0002151BD5B" modified="2023-09-13" version="1">MLNPEANKVNILYECNCGEKVGVEDTYYCKSCGKFYCNNCTFEEIIQYYCPVSFDTFGLSEINQIQGKSQKHFECPRCSSQLSPMVENQNETISSYSLKCNYCNWTTKEIGIETENIKSLINIIIQNEKEQKITVENQKQMKQLINYYNKKINPTKNLFKYSSPRNSPLNSPLKMVSSPYKPSYLYQPISNQSLSTQFSSVLSNNPKERVTVSELENELEKREKEVIIRSKNVDKDSIIDDEIEKKELFGNIDLNESINLERKLQEIPNQPKNEKDLFPKRIKLKSKKGRLCLSCGHPLIKPDLQQNVRFKIQNFGLLELPKITLLNYPIFKTKEKTEVFIVFTNLSSTPIQINSLKFSLESSLLENQNSPTNFIVQKFQESFFQSGSPSKQTIIEDLKSSNIAIYNNKVYIKEFITLQEEIKEKFLNLRLEFNIELEEGENKKEIKLKAIIHIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R799</accession>
    <name>A0A9Q0R799_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fam11a b protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R799"/>
    <dbReference type="OrthoDB" id="5955317at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="89"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="509" mass="60992" checksum="1D3E9D9A9E44E5D1" modified="2023-09-13" version="1">MLIIWIEIEKKNGVFLFEIFFIFFLCENKMRKSIKRNLKSTENIETRFHLKIYKSKGVIIIPKNAIELIKNGKYLESNKNNQISPTEPNLIIEKLPLEILFMICEYLSPGDFIKFGMTCSSFQDICNDQETWRRIAKSYQKFFIYDYIQRDSYTNEIVGFQSWNNPKFETFSLKNGNEKNREKMKAKRKKEQSKYFNNFIVDESTKQNSSGRNRPIIQSSKQERIEYIDSLENPKEEMIEKGKEIYEIFLEEKLEQEKSKRNQKFDLKRSIFEDKSEAFLTPILLILLSFGSTVFLVMIHLKIEKKIDYKLIYLMHLEIFEINDISDFFEFPSRILTLFSILQVIFIALRVDDYIHWNWIVVFIPLLVFLVFMGIFLLITIQNMEFGNLGIFPIFLLFFFFLFFLFLGLRMDETIKWKYGIVFIPLYLEFFLECCGSAILQNLTGVIDLFLLRLIVIIYFCVHLICLITIPIYFENSQQISLYFFFSFLYLLFLILDFGSIFFFKKRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7K8</accession>
    <name>A0A9Q0R7K8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7K8"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="125"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="436"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="71166" checksum="11151B756498BC4D" modified="2023-09-13" version="1">METNLLNQKAIARLNYRSNDLSLLCFNENDEIIINEQINKKWVKGKLIKNNIEGIFPLNYVKLQNPIDPKLDPKLKYQKNFNQEIMKIFLTDLNPETSYLESALLKKQTVPLIKLYKPTRLPLFPFSRKGWLMIGSSNGKWKKKYCVLEDLSLRYFPSEKENENEMKSIYIDKIMCVIRDSFQTTEKNSDSKTKANSNQKSKSKSNNKNDENFAFRIITKNQKNYHFQANSKKEMDDWINIIYLCQDILKFCSYSSTTEDIPTLKSLIQLMEIVYRRILEIKSKKNDQENRKMRDRLKVIDLWMNLWLFKYYLVLKNKFNGESYAISIRDQESEAHNGLELRKYDSARILFAKQEEKWIGKGEKSDGYFTQESIALLAFDSNQENGQKSDEKIVDEPLFFERKETRNFVSNDLPEGFLINKALSILNYETKTNEFVIQKNGILYYQYEKQQESPQGWKKKYLILSNFYLNIYASDKEKNPEQTILLDKTTKIEKLQQKDKKNIFTISTTKGLVFKFYSTNLFVIQEWIQMIQISIYLLNIYEPINPENREIESKIHEIEELLKWIQESILNSEILISSLRKMENDCKDQVQEVGRQPYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R900</accession>
    <name>A0A9Q0R900_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R900"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29638" checksum="1CC53BEC0465CDF0" modified="2023-09-13" version="1">MNDCLFFGRNKKPKLIKNESYRITKPIQFENENENENENENENENENEKQIKQISTRNYSTIFLFKNGKAIEYLENSNENPQKIQIEENIQKVTVGNLNEAILTKEGNVFAKGKDINSKNPKEFINISLLIKDTNDRIIEDFVSSRDSIYLLTSNQNAYGIGSNGNCELGFDSETLKKTEKPILMMKNISKIFSGNDSTQVFFLNSNQELFSCGLNDYGQLGLGESRKKEINIQKLTKIQNIPKGKIIDIQCGNYHSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R954</accession>
    <name>A0A9Q0R954_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uba domain-containing protein rup1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R954"/>
    <dbReference type="OMA" id="HENGTDE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="224"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="976" mass="114974" checksum="FE39E245182F5250" modified="2023-09-13" version="1">MSGEFPFSHLNLESEECQKTISQLKEMGFLEDKIKFGIRKVGNFPEAVIHFLFGENTMDVNKEEPDLPQTNKDSGQNKNDSKTHIIKDKPNKEEKPLFTDVDIASGYAQKEIQKVMTLGYDYDKIIDAIRYVGIGSIDIINYLKTKMTPKEIIESNQQPLEVFEKVMGQSVINFPDTLQDMSHGGIIDRSSDFNDKDMEITHNLNMENIFREPVDPYQMLKKKDFLSGLVNGNQSLNSLLLSLFFIPQIQNIFLQNKLENSENSIFNQIRLIFSKLIQSKKNIVEGKEIYKQMKIRKKEKLDQNSLSNIFETFLEIMNEELKNDPKKMEIENQIEIEKNTQNSQIFKKLKEFFQIEISDLIINHENGTDEFLVNESNPIEANQLEVLLENSINSYQILNNYTSLRKTDEDDKFRSNRIDKFPSILILNLKNEESDKNSNSHKIPKFNLDEKIYLERYLIENLNEFENKREEDQNLMNKINKLNEEKEKITNFNKTDKTADFFISTTINYFTQKYGVDEKKLLLSTLNYESQRISKYVKKIDADLEKITSEKEKLFDKYKSEVYHLHAVFAKNRYYGNDYTSVFINYLQQDKWWMFNQNGSLQMTFRNVQKNLEEGVLGLIYLSESLVSNKGEFIFKNTIPDELIPQIEEENAQFQEKLDSWDKRKRNHEVDGEIHELKRKFDEGFESQIKDFSTMKEDPTKDPLLFDLISFEIGNDRYIQAKFLYISQLYSEKFNGSKLITDYETGVYAASKLLSLISEFKHFNFRRIKDEDEFEWEDYKQSIKYFLSGLVALLNGNYYESCIFLFHKQKSRKRIDDKIAFIYIRLSLQLHFNILFTQDLSTFNNIDQLLTFLINSSLLIELSMFYLKVGLSTFSLARGIDPFISKLEKQFENNLDQISENLQKNNLFNEEVSNQLFQISNNFKKIPKMGENEKTIPNQDIYENDIQKFPSLFDAFQSLTSQVREKYSQEINDLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9U5</accession>
    <name>A0A9Q0R9U5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9U5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="246" mass="28866" checksum="6490BA569D313729" modified="2023-09-13" version="1">MIHSKTKQNKTNKNNNQFSISENTIGSIVTQSKNEKNENSQTNLQIYQQNNMDIDINEFKLPNEWLSLFPKPQYKPEIYSSLIHPVDNNLKNDKNKISIIQSQISPFNNIPLLFHESENSFFIQDDDNENINENINENINQNINQNINENINKNINPNINENINKNINKNINGNINENINENINENIKILMKILIQILIQILIQILMKILIKILMKILIKILIQILMKILMEILMKILIQIKILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAT4</accession>
    <name>A0A9Q0RAT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biotin and thiamine synthesis associated domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09673</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAT4"/>
    <dbReference type="OMA" id="YLAMEVQ"/>
    <dbReference type="OrthoDB" id="10261561at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042364">
        <property type="term" value="P:water-soluble vitamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024007">
        <property type="entry name" value="FeFe-hyd_mat_HydG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034428">
        <property type="entry name" value="ThiH/NoCL/HydG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03955">
        <property type="entry name" value="rSAM_HydG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583">
        <property type="entry name" value="2-IMINOACETATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583:SF2">
        <property type="entry name" value="THIAZOLE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01081">
        <property type="entry name" value="cleavage_of_the_Ca-Cb_bond_in"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00319">
        <property type="entry name" value="Fe_hydrogenase_maturase_(HydG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="137"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="531" mass="60596" checksum="FA2FAB012866332A" modified="2023-09-13" version="1">MDPILFKSKKNIKNTLLTSNFIRKLSSSFHYNGTSWSPETETNYKLPEVRDIIEEDKIFEALKKTEHKAKDKYTIRQILEKAKDHALLKNVKEDLKDEFVQGLTLEETATLLNMDTNDRNLLDELFNTALFIKQRIYGNRIVLFAPLYVSNYCTGGCLYCGYRHDNVDIPRSKLTKSQLINEVKALENQGHKRILMLTGEHPIYTFDDFLDALKTAASVKNPPHGEIRRINVEIPALSVSDFRRLKATNCVGTYTLFQETYHRESYRKIHPYGAKADYEYRLFAMDRAQIGGIDDIGVGALYGIYDYRFEVLGLLQHAQHLDRTYHAGPHTISVPRIKPAKNTPLSDNPPYAVDDITFKKIVAILRCSVPYTGMILSTRETTEMRKEVMKLGVSQISAGSITSVGSYSKSNQNSESKGQFSISDQRNTDQVIQDLLKDGFVPSFCTGCYRLGRTGEAFMKIAKKGNIVNMCLPNALTTLTEYLIDYSSKETAQIGWNVINKEIFNIPNLKTREITKRNIEKIKKGERDLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB76</accession>
    <name>A0A9Q0RB76_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB76"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="627" mass="73335" checksum="BC417E66B3130719" modified="2023-09-13" version="1">MDFYYQQVKNKINQISQENLKKQIQEDLELFNLIPFEEKEKFLGILIEIDQSIQNQQINKIFDSIFQFEEMLKTIYMQIFGENLPLYLNSESQNYNNEIIGNSLTQTNLNITDNNSINLSKEEMDALGKLDMVNPNQKIQKRRGSFSNTIDLNNSLNTKEKKEKKEKKRRGSFSNDTGLNNLFNTKEKEKEKNNSFPNDIGLNYLLNIEEKERPKEENNSFLNDIDLDYLLNIEEKQKQKPRKRGDSFSNDIRLNHLLDRAERQKAKKRSDSFSNDTGLNNLFNENSILNRNSNKITNQYNPNNSIQTKPIPKKKPKKKPKKKSKTKTNQTNQRRGSFSNDTGLNNLFNENSILNRNSNKITNQYNPNNSIQTKSVLKKSVRKKKPKTKTNQTNQRRGSFSNDTGLNNLFNPNSSLNQNSNKITNQYNPNNSIQTKPFEKKNQKQKSNQTNQRRGSFSNDTGLNNLFNPNSSLNQNSNKITNQYNPNNSIQTKPVLKKKSVLKKKPKTKPNPRRQRRGSFSNDTGLNNLFNPNSSLNQNSNNPNPRKTNQTQQRRRRRKKKKPTNPTLNSNPNPNQYQNPNQYQNPNQYQNPNQYQNPNQYQNQYQNPPLKKQEKKLKKKKSDCFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB89</accession>
    <name>A0A9Q0RB89_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylinositide phosphatase sac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB89"/>
    <dbReference type="OMA" id="ITKAQPV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="110"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="582" mass="68945" checksum="B5C4523E03DB63FC" modified="2023-09-13" version="1">MKNEKEKENENENEILQINRKQFGMQLISQQNLDSIKQKISEQKKIEGIFGIFEWNKSYYLIVIEKSELIGYICKNPIYQIKKTEIIPFTQKEEKEIENSKSSRILIKMLRKVLQTKGLYYSPSFDLTNSVQKQFERYKNSNEEIDSKYLNFLNYQGFNSFNTEYLWNKIFIKSFIENQLQNYILPIIMGYIETREFRINNKLVQISLISRRSTFRVGKRYTRRGVNLEGKVTNFVETEQIIEQSLDQRIVSFVQIRGSIPLLWSQFPDFRYNPKKKFSEANEEQVKEAFSKHINQNNEIYGNQTLVNLIDKKGSELLLENEFKKQCDIYNKTNTKTPVKYVHFDFHAQCKNLQWGKLSILMDQLKEDQQKYQFFCFEKKENEEENVIKQTGIFRTNCVDCLDRTNVVQGLLARRNLEEELRKQGIIQENEKIEDNKELESYLKNLWANNADEISIQYSSTPALKTDYTRTGKRTKKGALNDLKNSIKRYFLNCYRDWFSQDSLDIFTGEFDISSHNSKLLDNYNERPFWKLILLILITLLLLIILLISFGKIGKNLTKKTSRKLLGFPQLIKDSSGVKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC11</accession>
    <name>A0A9Q0RC11_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC11"/>
    <dbReference type="OMA" id="PISERRC"/>
    <dbReference type="OrthoDB" id="10265866at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07726">
        <property type="entry name" value="ST1585-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037482">
        <property type="entry name" value="ST1585_MBL-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF22">
        <property type="entry name" value="METALLO BETA-LACTAMASE SUPERFAMILY LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="354" mass="40479" checksum="DC20B419C906DFCF" modified="2023-09-13" version="1">MLQTIFKTSFIKKTTQTIIKKFITTKMGDLGRSTVETIDTYYNNSEKFAAAFLLREPEVLSKEKAKEKEEVAFIENNTNKAIPFLLDRLEKQNIAFESVKYLIVTHIHLDHAGATSQLVRKLPNATVVAHPRAVPHLINPSKLIAGVTEIYGKENFEKLYGEILPIEKNRIKSVEDYETLQIGSRNLTFIHTRGHAKHHMCVYDSVSKGIFTGDSFGISYPLINKKCQNLSSILFPSTSPIDFEPDQALLSLDKIINTGASHAYLTHYGIWEDLQFGKKLMTRNINKLNDILLKAKKLKLKGEKLLEFCQKEVDNFFIEILAQEKIVDDKEAWERLYFDRTLNAEGIAFCAEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC33</accession>
    <name>A0A9Q0RC33_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase ulk3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC33"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="79" mass="9348" checksum="AF46CA58521C6B33" modified="2023-09-13" version="1">MIMEFCNMGTLASYLEKNKREITIEKIKEIFSQIFHGLNYLFKKNMVHRDLKPDNILLKRSSKSKLGFVIKLEILDSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCZ0</accession>
    <name>A0A9Q0RCZ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCZ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="239" mass="28459" checksum="97362390C986ED51" modified="2023-09-13" version="1">MSTLQNTLIQWIFQLNSIEKPKEISRSTLLLHLEKIAKSFYQNNYENFSKLNLESYLIKILQDNQISNSTIENLQEMKDESFFNIVSKIKEIIDFQVSKNSQDSDSEIDENISQKFKKIIFFRMGKEIRERIPKNSKNQILLDSNKSKRRLFRKINLKELQKNTNENNPNNDINTNNNKKKIMKLVRQKKNHKIFEIENEYENENENEQNLGMNNIAKEELKNSKTKHQICKKISKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDX4</accession>
    <name>A0A9Q0RDX4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Manganese-dependent inorganic pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDX4"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="1">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="310" mass="35830" checksum="97676795D900BEE6" modified="2023-09-13" version="1">MDYYKNNFKNKRVYVTGHLNPDVDSIISTILMEKLLKWLEIDAKGVKLMPCDEITTNVTKELKCPEVPLIKLEELKNQDIFLVDHTHPISSIGENFPANIVGIIGHNPLNEVAKAPFIINGNVGCAARLIIDLMEKEKYPVSNQEYLWALYALAIDSCCLLKTSVTKEDIELANKWEKKLEISHQFLKEKTLFECDFNDKIENLARNGFKNHLFSGKYRGFSSYIEMINVNDQKMKKIEEIQNYIEKNNEVDLWIFFVYNFADPTTTIYYYGPLAKHFSTKTYNSVVSRGITVIPEIRKQITNLVESKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE85</accession>
    <name>A0A9Q0RE85_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related protein rab-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE85"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="304"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="376" mass="44790" checksum="4B04C253A3089C91" modified="2023-09-13" version="1">MIFFLNCTYRSFSSRKIFLITRYCDGIYNSSYGSTIGVEFKIKNIYIQNRTIKLQIWYPYLDRFRQSRTFLYRGTSGYMLCYDITDEYSFEFLKDFLDEIENNGNSAAIKYLIGTKCECENQRKISKQKAQDFADQFGLKFYEVSSKENINVDESFNQMANDILDNWDLIDPTSNIKKDAFSIIEDLRKFYERKEFCDDEIGCYDGNYKKTKIPIHKFIIQNRLHINDNIFQKKIKPILSQNNKKDVESLLEWVYLGRTQSMTNYSTFRDLKEKLSKVCQTTFDIGLKGLINDFKKIMNDEESKDFEIISNKERIKVHKIMLIIRSELYRGMFLSVTEDKSNSVHDYSHFKTETIRAMINFFYTDDIPNRFKQNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF52</accession>
    <name>A0A9Q0RF52_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF52"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="225"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="47222" checksum="1B2223C2A0E3FC40" modified="2023-09-13" version="1">MDNNNNNNQIQNANENQNENEMKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILNSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIENKEKENQQMKIEIEDKWKKEVENKNKEIENKEKENQQMKIEIEEKWKKEIEKMKPVFDEYEKEFEEIQKKLEPIKKNFPQFSETRIITEEEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLIIIKTKQNFIFGGFTQVGFKYVQSSGENSNDSNAFIFSLRNDKGDRIPAKFTYKQGRAIYSNLSYGPIFGSGYDFKLESNLQPGYSNFGYSYNPPNGITWNTDSGKSYLAGSYSSWEVDELESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFA3</accession>
    <name>A0A9Q0RFA3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arp2/3 complex 41 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">p41-ARC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_06011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFA3"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5077488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="586" mass="67461" checksum="9464A6011E3CB76C" modified="2023-09-13" version="1">MIRNQRVATSITTAAFNQDMSLVAFSPNSSKLELYNSAGKEFEFVDRFHDHQQLITGIDWAPKTNRIVTCSEDRNAYVYEFSKTEKKWKPVLVLLRIQRGATDVKWSPEENKFAVSSGDKIVSVCYFDEDQQWWVSKHIKKFRSTALCVAWSPDNVSLVVGSTDMHVRIFSAHIKEVDQKNPNVQEFGSVILDSPMLSWVQSVAFSPNGEWCACTTHDSRVAFINPANQQIYDSPNLPFVCGAFLSETSYVAAGFDSNPNLFKFDGNQWKFVGEIDTEKTRGSIAEGPTKKSSNFSRSRDLFQQRVTRAQDTMEGTDLKTCHQNCIKTIQVQHGQRFATTGLDGRIVVWPFGVIEKSLNNEIEYENENENEIEYENEDEIENEDENEDEIENDENEIENDENENEDEIENEDKNEIEDKKPKSKPKSRSKSRSKSRSKSKQSKPKQKSKSRSKSKQKSKPKPKSKSKSKSKPKSKSKSKSKSKIENEIENEDEIENEIEIEYENEDENEIENEYEIENEIEIEIENEIENENEIENENENENEIEDKKPKSKSKSKQSKPKSKQSKSKSRSKSKSKSKSMKNQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFI7</accession>
    <name>A0A9Q0RFI7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_00101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFI7"/>
    <dbReference type="OMA" id="CFARHYV"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5076784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="307" mass="33246" checksum="7B6EFCA39B7CC1A3" modified="2023-09-13" version="1">MSKIVIVGVATYEMYSYVSRFPKSGETISGDSLEIGFGGKGANQAIIAQKMGAKTSLISTVGDDDFGKQVIQNLVAYSVPTDHVRTIPNKKTGISFVDIDKDGNSYTVIHAGVTKDLTSKDIEEYEEVFKDAKVVLCQLEISVDVALKALELGKKHGAFTILNPTPGLRDLPDQIFKLTDLLCPNTAEAENIIHRQIETSKDTSAAGKDFLKKGVPHVVITMGGKGSLYRTEKFSKVFPAPQVNVIDKSGCGDAFVGSLAAFIAEGMDIEKAIEFATLVATEAVKRKGSVSFCPKRDELEFLKEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFI8</accession>
    <name>A0A9Q0RFI8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFI8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="473" mass="55070" checksum="879EF5253B7A36D4" modified="2023-09-13" version="1">MTFFEPESPIDFDPSFESESFLSSPYSFGEELSIQSEYSDSLFSETGIKGANYEEKTEEKRGIKEPTNQASPNTSPMSGFEMANQTSFDTSDTTPPKQRKRNVRRKKRAKEEKTTNQNKERNKNSQKLNKKWNENHKTILEQQVSELTLKNLRAMVQTESVEEYVKVIEEEICKITINNIVLSAKVEALSDERKKSQTELERLKEQNRELRHKLGRYRKTREPTPTNSGNVSFMNNEIRDAFAKVFQQQTQPQNNDPFDFLPDNNSNVPDSLFSQVDLSLLTSMSSPKFIQELYQISQIYKAKQKILQKSQTDLSTDFEKLSVCDQDDSNIPNEYSNQIKKSKEKPVQPEYSQVVSNKKKNYTNPEYQPRKEVQNSPLKKENELKNESENEKQLENNLENQIEKNNLENELQNELKNELQNHFDSDSNSNSDSNSNSDSDSDSDDKFEFQQELLTLHHFQNEIQRLTQKLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFQ1</accession>
    <name>A0A9Q0RFQ1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFQ1"/>
    <dbReference type="OMA" id="INWNTNE"/>
    <dbReference type="OrthoDB" id="311690at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="40"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="216" mass="24618" checksum="C2401C5B93F751B0" modified="2023-09-13" version="1">MKPVFGDEIEDMKPIFDKYRDQYQKDLEYEKKMKAFSDSEIVKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKQNFIFGGFTQVGFKHSSGENINDSSAFIFSLRNDKGDRIPAKFTHNGNGRAICSGLSYGPVFGDGDDFSLSSNLQPGYSSFGRSYNLPNGINWNTNEANSYLAGSYNSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGI6</accession>
    <name>A0A9Q0RGI6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor spf27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGI6"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="61"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5079257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="213" mass="25675" checksum="AE223B36892BA66E" modified="2023-09-13" version="1">MFQNLDFLAYCDTQIEKPEIKQKVQKLIEEEKRKSIKTINEYLKEITSQDQFNQEVDDFLLKELERIQKEKENRLDFEKKYQDAVELDLDSVGNDVEKMKEKISLMKQSLENQKIKIVNTELLSEYGENLHLQFNSNLNSTKQFYANQLQKNQEEIQELNNKRMYLQLLEFKNIEKMEKQWNDLVSKNFKTRKACEKMNQEFEALNEVKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHH9</accession>
    <name>A0A9Q0RHH9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin reductase</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHH9"/>
    <dbReference type="OMA" id="GPCHVLK"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="26"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5079843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="329" mass="36212" checksum="7297137606B26F68" modified="2023-09-13" version="1">MEVQKVDKVSYDIDPKLDFSKAEHRKVIIIGSGPAGCTAGIYTARADLKPLLIRGNDPGGQLVRTTDIENYAGFIGTGPELMMKMDEQAQEQGCELIFGEVIAVDFSVRPFKLVLFPDICYTADSVIIATGASAKYLGLESEQKYMNKGVSGCATCDGPLYRNKIVSVVGGGDVAIEDALFLSRFCKEVHVIHRRRELRASKPMQKRAFENPKIIFEWDSVVDEILGDGEFVNGVMLKDVKTNEKRKLVCAGVFMAIGHKPNTDVFKKYIETDEVGYIITKNGKSHTNVEGVFCCGDAQDKEYRQAITAAGSGCKAALDCERWLATQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHS6</accession>
    <name>A0A9Q0RHS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_13992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000008">
        <property type="protein sequence ID" value="KAJ5080547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHS6"/>
    <dbReference type="OMA" id="PLMRICR"/>
    <dbReference type="OrthoDB" id="2804215at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="631"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="881"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="882"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5080547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="926" mass="106223" checksum="C97FCA66AB8E35AC" modified="2023-09-13" version="1">MEKLYDFLNRNMRFEQAYQQSQVKKNEKDENKTILHLACEYNSIDIVNKLIEDGASLTIKDNGDTPLHTACAYGYDKIAKTLITKGAPLTLQNKGMTPLHNACWGGFFKIVKLIVKKSTEIDQKNKGNTALQISCFKGFGNITKYLLSKPIFLDNQNDGRTALHLACVSKNPQIVEELLNSGANPNIKDHGFLPLHIASGNGSIKIVEHLINHKANVNLKNDKETPLLYAIQEGNIEIVKLLLENHSNVNPTDNQTPLQFAITNNHFEVIKELIRYGADVNKSNDEGCSNIHLACVQGNHETVKLLLKAKANPNDLDIGSTPLHSASENGYFLIIRVLLEKGAEIDIKNKGKTALHLACENGRIRSECDPLTIAEEKKYSEVVHILKKYINGEDYSYVLSESQDFIEIEKLLQESIKKKEEEEEKEKEKEKESHKKKRKAKRSKKKQIENQIEIENEIENENENQIENENENETTENETTENETTETETDIENENDDDDDDEKLIDLTSALIFKPSLIKENPTNNENINVEISEKKEPINNLSENTISENGINLNLIKARENLRSFLSSKDQKLAKIRTIKKNFNEQGLSLIENILIQKKQNNKLTDTDKFREQFSLTSKDRLLEFDPNSLTDVQKIGEGAYGTVFKAKMDEIDVAIKYFKFKLQKKERERATSEFKILKSLNYPFIVSFLGYSLNPYCIMMEFCDQGSLSDLIYNNKIEFTQEEMFKIFKEITFALIYLHSKQIIHRDLKSQNILIDQHGRVKLADFGLATFTDSEKQLSAVGTPNWTAPEVLQRLKYSYSVDIFSIGMIIYEVTHRIIPFDKQNIFEIMMNIQNGIRPSLKDDNIFNDIIVQCWAQDPNERPTATELLTMLSDLETQTKNQNQNQNQNSNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L742</accession>
    <name>A0A9Q0L742_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sorting and assembly machinery component 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L742"/>
    <dbReference type="OMA" id="DMNGEVF"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.310">
        <property type="entry name" value="membrane protein fhac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="482" mass="54012" checksum="669F5F85BAF243B8" modified="2023-09-13" version="1">MGNQTTSSNFKISGVNVTGLKKTKRSVIESQIEPVLQQKTYTEALKTTNQALQELQKLGIFDEIKIEFDSKNIKTCPEPKKPVLNVSVREGASEQAKIKLISVNGDVGLGGLVAAKNIFGKAENAGIIIGFGMESRLIQANYSKPFLNKFGHKNSSVHFLAYHNKIPYSLSSFQQKVTGAKFEICNDIFNPAITELIHERGLGSKKPLHFFSISSDFSDVIVDEKASWKVRKQAKHSFKLSLSHESVLDKRDSLTFPTQGIFLKSQNEVAGLLGGNVHFLKSKFQGQLHFPIIKNLLNFHLLSHFGVIIPTKVDEKIGINDKLFFGGFTPFRGIHEHSLGKKIKKPEREENEDDTMAGYDLFKDYPKFIRDFLNPNHHKFDILGGDLYGLLTGMVSLKFPFNFPCNLQFFASSGNLVSHSNLDSNYLETIQRAFDKRKTIVGVGLAFGIGSNRIEVNYTTPIKITEQDPTYPISFSMDLHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L780</accession>
    <name>A0A9Q0L780_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_02830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L780"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000592">
        <property type="entry name" value="CAMK family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="12">
        <location>
            <begin position="667"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="553"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5067642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="717" mass="82432" checksum="ED854F9E967DFED4" modified="2023-09-13" version="1">MEKQLSTKEEVKPINEYQLIETIGKGTFGEVKLALHSLSKLTVAIKVINKTQILANPEAKTRLSLELEILKNLNHPNIIKLYEFFETDDSIYIVMEYASGGELFNYLSTHGKLSEKQARKFFRQMIEGIDTCHRRNIAHRDLKPENILLDEKGGIKIIDFGLSTVIKPEELSKTFCGSPSYSSPEIIQGQEYNPMLADIWSLGIILYCLLCGKVPFYGETPQEIVKSIVKNNYKLPSGLSSEVKDLLKKMLQKKPEQRITMDEIFKHPWINIGCFSPLVPQSVEQTVAIKLDFTVLDLMNDHGFSQELILKSLKDPQMNPLAACYYLFVDAQKIENIKLYATSLQKIKDKMKRNKSNLEEKSKNDENSQNVENSKNDENSKNDEKPKNDEELKNESKTANDGKSKLDEKSKNPKKSKKEAPKSPKKTRSIFFWRRRRNKANNNNKTNRRNQRSKNNNKNNSKKKEEKQKLDENFNKLININQPGNFEDLCRLTPKKPSKPDPSENNIISIPITNPYQEEKPQRRKLRKRGNPQLLDKYFSENQKPTTPQITIAQQTAIRPRSTTATQFANSTPQSQTTASPDNEKNDQEETRKPRAITISNNIEGQQKNNELIKNISSEEDSDTREVRGVLSVSTTSTKSASDLMKLCTKVLKKNKIKFSKVGKYSFHCFFDAIEFHIEIARALNFTDLHVVVFKRISGDFWKFDRIWKILSSNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L823</accession>
    <name>A0A9Q0L823_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L823"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="141" mass="16815" checksum="CBB4775D18EE36CA" modified="2023-09-13" version="1">MILNIDNDIDFGFDLDFDNDIEEKELFNSNQLIGKRLDILAKIRPDLIKGWKSSTFKCFKKKGIIPEKVIIHDDGFHFMAQCLEITNFEELNNPTQEMKLKYQKFIKNYKRSLQKFLQNTMKMKRIKTNGKQHQPIIFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L892</accession>
    <name>A0A9Q0L892_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000119">
        <property type="protein sequence ID" value="KAJ5068167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L892"/>
    <dbReference type="OMA" id="AHRIHTH"/>
    <dbReference type="OrthoDB" id="5984158at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="98" mass="11860" checksum="AA4AE4D60086EF32" modified="2023-09-13" version="1">MNPNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8E0</accession>
    <name>A0A9Q0L8E0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8E0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="580"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="614"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="647"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="680"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="714"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="747"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1108" mass="128187" checksum="26CEAAA21948C9AF" modified="2023-09-13" version="1">MDIFQIIQENNIEKLREIELKTKDEKPILHFAIEKKVSKEMIQLLISKGIDVDLIDNKERNSLHIAIMNNSEIEIIKLLISKGVDLSAKDTMQKSILHYSLIYLKNKNISFEIVKLLIEKGIDINEKANGNQTALHFACQNNNISLEIVKFLIEKGIDVNEKAYGNQTALHFACQNNNISLEIVKFLIEKGININEKTNGDETALHFACQNKNVSFEIVKLLIEKGIDINVKENTRRTALHIICQNKNVSFEIVKLLIEKGIDINAKEFYNKTALHIICQNKNVSFEIVKLLIEKGIDINTKESDSETTLHTICQNKNISLEIVKLLIEKGIDINAKEFYNKTALHTICQNKNASLEIVKYLIEKGIDVNVQSSYGGTALYYACLNRNIPIEIIKYLIEKGININTQTPYRKKTPLHIALVNNDIKKFVNYIIEKGFDMNSKSQPKIIDSHLNFQKRSFQIVKFLVEKGIDINARAEKNETALHIACTNHSSFETIQYLIEKGIDIHAKTTDNRTALHFAFENHLPVQVIELIVEKGFDINDTQSQNKTALYYACQNEKYLEIIKLLIAKGMDINTKIISDITALHIACQYNSSLEIIQYLIEKGIDIHAKTNDNITALHFACQNTSLEIIKYLVEKGIDINAKTNDNITTLHFACQNTSLEIIKYLVENGIDINAKSVNNITALHIACQNNSSLEIIKYLVEKGIDIHAKTNDNITALHFACQYNSFEIIKYLVEKGIDINAKARFSETALHFACQYNSFETIKYLVEKGIGINAKSNLSETALSICIEKKKNPKIIKFLFRNNANIANLDEEDQFSKQFFEFIPQIYSFNDDIHTLLKSNDNFSDFQVYSNDSVKFQLHKLILLARLDNNQLILEKFTNICKQKSKEDVQMVLNFLYTGFPHFDRVIQKSHDSVSYFEQKKNIPKDYRGQKIPYEQIPVKIEELKTLRKYEKEKEDEIEIHQQKKIEEFFKEINLDSKWVESKKGRKGLLEDFHQLYKQDSTKDFTIICEKDKEIKVHKLILIIRSDLYRGMFLNVQDSSDQVHDYTGKSFETLDQLIYFFYHDEFDKTKQIKKEEYEDLKEYFQLNQNSMIDFLLEDLDFFSNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Q5</accession>
    <name>A0A9Q0L8Q5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8Q5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="292" mass="34304" checksum="9986A0FAF5B63EA3" modified="2023-09-13" version="1">MLRKHTSIPKEKYITSNGEKNPSEKQSGVSKYGTIKTGKKALKVQFEHSDPETTTVEVQQNRSISGEMSPRGIDSPRRRSQSLFVHKKQKKKKDTAEYSILFPILENFTVTQTSQKYCFLFNDCLLICDTKKHLSEFIPELYIPLHDLFIKLPLSEKNADIPKENESFFLFNSEHSLLITPQSKLDFWFEKIQRCIDDNFGVNSKENEKSLHKNDESNDNLRLFSCRGYWLDPNSKDNLRFVKKFKFVGIDLNEEILKSKIHFKLQEESGFIIKKKTFNFYPIFKFLWKMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Z9</accession>
    <name>A0A9Q0L8Z9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8Z9"/>
    <dbReference type="OrthoDB" id="10687521at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="875" mass="101949" checksum="7BE68DB14E9F9C7B" modified="2023-09-13" version="1">MFPTISKLNSSSFPFLRGIQLLEGINDVNQIRFIPGHIALCFASGNKLCVLDNIESNQTEKLTTNSNDVLFFVSESPIINFTFYKQEEFDMEIIPENQTNISVLIDNNNNNGNSNIQIVKRKFVPKNKNIDNFIFLLAVTQDGNIHLWKWNQHIFSWESFGNQNLLSESDPNSSLKTSHTKITQAQFLMNSHVVFVEKNISSSTYKMVLQKFNLEKYKADTTKKFVIFESLKKPPQKDIIESLIFSDGKSIWISDGEKLSCIPFAFLILDSNSSPKIQELQLDCSDILPNSFIRIEYDQSQLLNTTGLLVLDAKTYEVFLIDIFVDQITQKSLIQKKLICKLALSDLHNEEDLKIQNVFLFRDYISLVFFNLRFHSFEVDVHNYRTGNFLSKSDFPNVTSIQNLKESEKQNLNSEDRRSFINTQFKSAVSTANGALLFNDICNDIFIFSFSSVKEQFQTISNQIEKSNQNQNQNQNQNQNQNQNLILAEISQNWNLNRWEMKYLIQELDRIDPMKNPNEKLKIAQLLLEKIQNPELVFIFLSSLPNYNFLQEKIDKFVSEISTSPTKFFEYNSSFYNQIEPILKDFNSVTNSLFSENLESQKEDILGYNEFENISLLEMDQNEIDLMMIEDPQKLLEKFEKEVTENDFFESVNYSIEDELYSNEKTQTKKTTGFGYEFSLNQKEEKTVKKNPLFSYRCRLLYQYQPEKLVKFIKSIINLSKNEETKAKIYNLSLLSLPMLTENSKPTSLQIKSRAKILHLANRIFEGFRLFLQFKMWDFALKAIHNEKKYSTKQMGSLWLMLFKSALKSKEVNVIVKMIQDAPKSYSSFELFSMLNEFMTHELKSENDEKGIENVVVDSESLISMQHIKDLLLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L968</accession>
    <name>A0A9Q0L968_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L968"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="304"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="532" mass="63625" checksum="DCF36376D08FB61F" modified="2023-09-13" version="1">MMKNVSKIFSGNFSNFVFLLNSNQELFCCGDNIWAQLGLGYTVEWYINKLTQIENIPKGKIIDIKCANWYSIMLIEDQNQKRKLYSSALDQYNQISKYKNKDSKPFTEIKSSRFKNDHILEISCGYEHTLILTKKGKLIGFGWNAFGELGTGDTNDQSIPIKIELPKLRFNEDISNYHIYSGFHKSFFYYSPSFSNLEEDLIKLFQRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQIEIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILLMRSELYRGMFLSVTNDTSNKVTDYSELSNEAFQIFEYWIYSNQIKDGIQITKEIIQVDDYQELNEEKFEVFEYFDNTNQITKEIIQFDDYNELNEEKFKNSKHFDNKNKQDQKGIKITKKIIGEIEKGIDYFQLNQTYPNLLDLIKQEFIKFEIKQKKKQNTKQNTKQNTKQNTKQNSKQNNKECFIFNFFFFAFFFSFFFFSNKRKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9V6</accession>
    <name>A0A9Q0L9V6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Wd repeat sam and u-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9V6"/>
    <dbReference type="OrthoDB" id="10064100at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052085">
        <property type="entry name" value="WD-SAM-U-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46573:SF1">
        <property type="entry name" value="WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U-box" evidence="4">
        <location>
            <begin position="282"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="359" mass="42167" checksum="4BDCA218FE20CDA2" modified="2023-09-13" version="1">MGNKIIRKKIKTSRKTKELDLNSLLEDENFIQKVQSNLNLIWKETELLALNLSYNELNKIPSEISMLTKIEFLDLSSNKLSELPIEVGNLINLKKFYLKHNRFELFPNPILKLEKLEELDLRENLLVEVPPELGNLPLKVILLSRNINIVFPPLEILQYDSQVIINFLKEANEEKIRIENQNQNQYQNQYQNQNQNQNQNQNQNQNNQNQNQNQNQNQNQNNQNNQNDEYNLSRSLENSNISWIPFIPTEIPKIEEDHSNSSPIFELRKKLHKIQDIVGEDNIPSDFMCPITLEIFVEPVKASDGFNYEKSVISKWLENHDISPQTNEKFPNKNLIENLELKQKIQIYIKSLNEIGIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAN8</accession>
    <name>A0A9Q0LAN8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAN8"/>
    <dbReference type="OrthoDB" id="2311693at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="569" mass="67852" checksum="216DF167AD93ECEA" modified="2023-09-13" version="1">MDSINQKEINSNLIKNYQKLIKSNQNYSDITLKIGENLKEFNCHKSILSCQSPFFDVYLKENQVEEIIFKEISEENMKQIIQFIYTGNIQINELNLIEILNLSIKFKLELLYKLIEKLIIKDFNLNYFFEIFGKFNNLSINLKEKCDKFIQNNLKIILENEKFEKLNQKSISKIIEIIQKDSQKQNEIPIITLIKNLEKWVSNKVEKEKEKKKTMKTFIDQITIKTIQNLINIDTITIQKISENQMIPNEFISYLFSSKMQKDKDEKIKRIEKEKKEKDQQIEEMRFIFEQVQREKEEKEFRELQLVLKDIQKEEQIKKVEQIRIEEEQRIQEEKRIQEEKEIQRKQKEREYKESQEYKEMQEKRENQEKENQEILQTVFKESKIIQDTNYIQYLKEWISNDELFKKMELGFSAINDGFSNKKFYSRCKGKTESLAIIKTRNNCIFGGFTEIGFVPKKGFSKGFKSNGKWEVDKNAFIFTLKNPTNYPPSKFNYLNGSCIYQSPSNTIWFGNGGYIGIKDLSTKKGISDFGYRDQGFEMPLGMKYGEESRNFFAGSKSWNIAEVEVYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB75</accession>
    <name>A0A9Q0LB75_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB75"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="273"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="459" mass="55432" checksum="ADA2DB217C8C2786" modified="2023-09-13" version="1">MDNKNNNNQIENANQNQNENEMKNLEKKNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNQRLKLRKYKHKMNAKKRLFHSFFSLFDKDSISKQDFDKLKQFDIFLPNSFLIHFERTIFEIQDQENQTKIKEKEKKIQENDKQIKENEKKIKRRDKRIKENDKKIKSFETENQNMKSEFEKEIEKKEKENENKEKEKKEIQEKLKKEIEKKDKILKQKDEEIQNLKLSFEKEKIKEIHNQNQNQNQNQNQNKLLKIFSNSEIIKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFDSKKWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGWTNDKSKWREEDRNRDDGYIPDSNAFIFSLRNNKGDRIPEKFTIKQGEEKYAIGYYLDYGPTFGNDIFLNSKLQPGCSNFGESYNLPNVIKYGTNEAQSYLAGSYDKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBF0</accession>
    <name>A0A9Q0LBF0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beach domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBF0"/>
    <dbReference type="OMA" id="DQMITNI"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Neurobeachin beta-propeller" evidence="2">
        <location>
            <begin position="52"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="302" mass="34507" checksum="6B7B36E359879216" modified="2023-09-13" version="1">MPYDKIVMLDENRMLHTFQFFLPSRSGQTLANQVPFIIDPFNPPKFQRMGVTFDQMITNIDQCFATTKTGKFLVCVGFWDNTIKIFDTDNYKLIQSVCFHQDVVTCVTIDDSDQFVVTGSRDGSVIVWRFNPKSGELEETPLHVLIGHDDTVTSVDVDSDLDLVVSGSQDSTCILYSLSKGRYIRSIIRKENAPISRIKIISEGYIILFCSKNRCLSLYSLNAKLMKDVLVSNITCWFFLDHHYFLIGSNQGRLEIRKIHNLKMVEYFQFNEPLTAITASEHYGFLIIGLMNGKMMIAKMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBH6</accession>
    <name>A0A9Q0LBH6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBH6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="72" mass="8651" checksum="1360601656B6384B" modified="2023-09-13" version="1">MFLSVTEDKSNKVTDYSEFKKIYKNDRKSNPNPKYSKKAKIIDIKCGYSHSMLIENEKNPKRKLLFMWILYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBM2</accession>
    <name>A0A9Q0LBM2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type 2 inositol 1,4,5-trisphosphate 5-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBM2"/>
    <dbReference type="OMA" id="VREDAWC"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04380">
        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000132">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase OCRL-1 isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000012">
        <property type="entry name" value="Putative inositol polyphosphate 5-phosphatase OCRL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="581"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="755" mass="86851" checksum="71E1246C3846E1D8" modified="2023-09-13" version="1">MGGDESTLSIKLPDITYKIKAPSNTIQHIQKELARALRLAQKSSFSSKDIGETHHSWILNYRKDGNEQIFTDVVSTSPKNRKNSQFKELENENEAHVSRSPMFSKLREEWIHHELMKKKAEFSEKKPMRVLMGTWNVNSQKPEEDISDWVRDDNGTPDIIALGFQEIDMTASAIIGNDHTKAKNWEDYIQKMLEKHPEEYVPIKTKLLAGIMVCVYVKKIHSNFISDIQVDDVAVGVMGILGNKGAVAVKFNCYDSNIIIINSHLACHLKSVNKRNQDQRNITNGLTFNDKTSGKTIFDSDMVFWFGDLNYRISFPDKSVKAMIEKKEFDALFEKDQLQAQMKAGVAFSQFKEPKITFAPTYKYDPQSDNYDTSEKKRIPAWCDRILYYGNDIECEEYRRHEFLSSDHKAVSSIFTIQVNSIIPEKRREYQNKLIKELDRMENESIPNAAINAHQFSFKDMKYNIPVTQSLILSNTGSVWVQFKFIPKLNESEICKPWITVDKNCGIILPGCETKISLTVLVDNNSALLLNSLNDVLDDILIIHLENGKDHFISVTGNYLRSCFATSLETLVNQPRPIRFASLNEKSTTEMSIPKELWRMTNYIYNNGLHEPNIFLETGDTKEMEQIRECLDTDQPFSIDATCYSMAESILMFLSSLPVPVIPYTMYKACIENSSSYIDCLKIVKQLPSAHYHVFIYIISFIRELLKHSKSNSLNPENIAYVFSSVILRPPFTDKKQVLKDTRKRLEFLLHFVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC31</accession>
    <name>A0A9Q0LC31_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spatacsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="IWITVEI"/>
    <dbReference type="OrthoDB" id="2018754at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028107">
        <property type="entry name" value="Spatacsin_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14649">
        <property type="entry name" value="Spatacsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spatacsin C-terminal" evidence="2">
        <location>
            <begin position="2134"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2477" mass="295294" checksum="745E73A62EBBF284" modified="2023-09-13" version="1">MHLNSQFNSKKNIQFNSKQENINLSKKEYKRTEDLKPIHFIDLKLLFQNEIDNTNPSQNFQFFISKSTFSFDYFSTLFSPLIQQENLQISSLDFVFSSQKNWKRKRIAFIVNNQYIFVCSFNKNYIIQCDSILKFQESITQDPPKFSISNNFLYCLFNNHISIWKLKNGKIFGIVENPLNLKNEKIKKDFIITPDERKIIITYSKALIQIIQLDEYFFYNKLLKPKHKNTEIILIPEEKKEKKKEKTNSKTRRREHHKKHEPKREFMNRKWNMSYLIYSNRFIDLPHQVQKINSEFYVHWYQANQKRRRAPNIHPSSHGWFPHSSHYTGSRMTGFVLPKIQKKNHLQKYMSQSDPSILISQNQNKSFRSQYIFYYHLDQEQNKWKKYNQNQITMENIQKIKDIQIYSLLATNDNICFSYEDQDSQNQNSLQKNILFLEIFDDRRIKYQEHHKEMEPLLLQFNENNQVVLTISYKSIFVLTSNSISSKIIHFSKAELFQKLAFFHNIALAENLVELNDHNVLHFRENIIEHSLNYQQIEVVNDILNKITSLNSISNLEKIISILKIKLTKYRPNFSKPLILICLNLTLDLISQISTKLLNSATNSQQDSHEIQLYSSIQNQLSFKFCTQQPQQHLLKDIKLMNSILGFLIQIRILTEKLYSTLAQSSSRYFGSKKYSSQILNLEKELPNYSHSVVQDPSLQLLHLSQLVYKSLISGKISLALSQIKDPIFINKQENSLTMNQQINLDLNLFWNNFYMKTVYLLIENSQFDQASLIIENMGGNPFKIMKNLSFLTLKKEIREKLYQFLKQNNQINQSEKRRYLVLLILHKLYPSSSYNQTHKILEDNFISKNQSRKEMIKVIEQRQFLWLEAQDFQEEWKFNQENKDQFNIISKEVEEIVTFQGIELIQSYFKDVSEKKSDPKTSDNNPSLNRYLLTKFKWFLSWDKFTKQRIMFEFLQKDDPLLNKYFNFIGSLNKPPALKYLFTEFIHLISSFNYNRIQYWISNLALENINTESLKNIFESMIIYVLRGSTLKLKNLVLNLFSLKRGIYFSFDNSNETNLFRKICFNFHLLFNDEIRGYSLDKLLPKQQTNNFHQNMINLFIQNELFNIFEFYLVHFQLTLQDKMEISNPLFSIIEFCVNTNPTQKMEKYIKHLLLLNTSILLNTQISNITNQLLINQNKFLIVLGMFMFNQKGFLSNFILQENEQEYVPLETISKCILDQFPKLYSFINSVKFLSNLVTEEYKINDNKPKEMDLVSLRKDTSLLNLINKTTSIHLSKSIQDYFFSKFLDHNSNFQNNFKEILDILFYLSYGQSVSYFFQLIKQQANDSFYNSQNIEQICFLITSWSIQNFMNNLFVTSSEKIIYNYYTQKVRNDKLDGKINNLKNIFKTSIYSKKYETIFYKEFILLNNINESQISRFKYLLIMVFQSILFYKDISMIEFVCNELSIICQSQQKNQKQNYIHLSKQEKAIKTLREFIQIHSSDINFVIRDCLTWNNNNWISYLILSKFTCDSLDEFEKHTNENVTNEYLKQHLLRTSQFIKKEKSKTENIHIISDSNEIEQNLNNDNSLTKGNLFDIILNIQKNNVNPSEHLLSEAISRKEPIFALISLSFGKKEDLLDCLISFLISSNQKNINFQEKLKKTKHWEIENLNEIIIWITVEIKQILILIQAFELFDSQNLIIHFFRFLRALNMKQVRKSKDHLLMFMNSKKQKYLGKIEDIKWVEDITKTIIKNYLEKVDQYTLKCLVNILNDVEFSQEYHIYWQVMKVFENIDITELSIIKEPIENIDILTNHKKFKESVKYSEIVGVSLFYTIIPNSISLIHEYQKSGIWKIESKREILWNQLAKIVYKNTKTQKSELNVDFFLSLIKMVFVELTYNDFVVLFTFAKEWISKYKFNDETIYTQIENQIWLFSLLKEIEYKEFPSFLLKMNPEPSKEFQEIFDNVLSKNNWKEKIKLQTLNFGKNQKIQEAGKLCEMTQFKSKELAIIHACEIIQKRNEEKTNFLEMIYSQEFNKDFNIAKIIQTRYPRINFNLISKERLLNKLVNLLVFGRKYCQRLITNYQISQILKQSYEQLEKEPYQVILKLLIEKYFQSILWKFENEENLLFSSIISFTQKSDNFQKFVSLSQDSVMFGNELLEKIKEIPEENPHKEDIEVDIIIRSRQAFDIKQDSLGSRKILEIIKEKSLIYTEKTRFDLLAQLLTGMTEYQEIQLLLSILVEHNQFKLISNQIQEKLTISILKISLIEFMKTYTDDDEKLLLFYCTFRLWTELGNHFFSKAFRMISKFDPNGSFEETEMRKLIEIGDLFFNAADSFAKSDCPQKILDCISYASLIGAQIRNPDLFLLNQEKSRIKIRKLIGNETINFFDALIISEVYHFSLIEDWCEIVFKQFIEQKNINFLDMFFFYFDPQPKFFSNFMNIYIGSQKNNSIENQMKSFILMIPDKILQFEIGSQLKFDKVVYQLKLIIPDIFNIKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCS7</accession>
    <name>A0A9Q0LCS7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCS7"/>
    <dbReference type="OMA" id="IFEIRSH"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="169" mass="19303" checksum="20F4FAF2BF61F563" modified="2023-09-13" version="1">MSDKIICSKVWIEGDVSIGEGTIIHPDAELIAKDGPIKIGKNNIIEEKCIIINQKKNENDQVETLEINDYNYFEVGSYVESRKIGDNNIIGIFSNLGKNITLQNGVVINPKVDLSNESMILKTNTIAFQKPEIHFHEIPNQENFNHEQIVSHLERLRKLLPQFHELKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDS4</accession>
    <name>A0A9Q0LDS4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDS4"/>
    <dbReference type="OMA" id="RITITFH"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052671">
        <property type="entry name" value="Acrosomal_SP-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571:SF34">
        <property type="entry name" value="ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571">
        <property type="entry name" value="URINARY PROTEIN RUP /ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1205" mass="143394" checksum="A2316DC26D314F13" modified="2023-09-13" version="1">MSSLFQFRKNFKHSKLRRKVIQQNLKLILLDNFELISSTHANWCIQEIGLLINQKINKSKIKKKNKSKQNLSNDELFKSYFDIIENENENQNIIKNENENENENQNQNQNQNENQNQNENEIENQNQNQNENQNQNENQNQNQNENQNENQNQNQNQNQNQNENQNQNQNQNQNQNENQIQNQNQNQNQNQNQNQIENENQNQNQNQNQNQNQNQNQNQNINEIENQNQNQNQNQNQNQNQNENQNQNQNENQNQNQNENENENENQNQNENQNQNQNQNQNQNQNQNQNQNQNENENENQNENQNQNQNQNENQNENQNQNQIENINQIQYENQNQNQNQNQNQNINQNQNQNQNQNQNQNQNINQNQNQNQNINQNQNIIKNQNQNQNQNQNQNQNQIQIQNQNQIENENQNQNQNQNQNLIENQIQNQNENENENENENENENQIENENQNQIENENQLIKLYICYIETICLWILNLEEPPNIFVVKKALEYSRKAIKLSPENKYITFLIAMLKIANFSVMDTNTHLFDIVEANQTLETIIEEQNPLNTVLRLRFANWLGSLIYSILKKNQLISQNSQKFIYRITITFHLIEMFKKHFQVLFQQDQENIPKSQMLYLVTDYSTILVAIANLLQLNDPQDATRKAKLFYDSIKEINDVIHKNPNLYSLWKTKRVLEVSILSNFPCISSFLSLIVSTINCLLLMPVEQQFSEFNSFKDELGKIIQKLFFSQDSFHFLMSEIIRTFENQIIFYQAKNNSNLNSDSIQKSKFSVSREEILIRLIFAMIIGDACFSALEFFEFSDKLQIYQVDQNEKNLFKFLNSKHLVNSKKEIYNTILEYLRLIVSHFQHVFVYSDHFFPQLELYAKFFYSKCQATISQIQLIFCDSKNEISEAIQNGLFQIQKSFFESLEINILSTEILQFAVSFLYYLSAEYNPVFFFRALSTALLYYRFLANRDLKNELIDSLLIFLKIKFEFSNDLLFIWNANMIQDIGEIESKEQNISQIFITSTHIIIVSKQFKVNKAVLESYLITPQNIDNKTRNIPDPHRTEARKLVKKLKKHPNVIKISLNNVFSLKMIHFKPEKLVCDFPFLIRFEIADQLGKRGQIILGFSSEQERTFCFSQLSPIINIFTQKEIYDEHNFFLHNILKSPSLDNFYNQFHIFKSNTKNVTQKLNQFFSDLLEFFRQNTSIFEYENSLLPSSLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDS6</accession>
    <name>A0A9Q0LDS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ceroid-lipofuscinosis neuronal 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLN5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDS6"/>
    <dbReference type="OMA" id="FRPHQSF"/>
    <dbReference type="OrthoDB" id="10005881at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026138">
        <property type="entry name" value="CLN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15380:SF2">
        <property type="entry name" value="CEROID-LIPOFUSCINOSIS NEURONAL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15380">
        <property type="entry name" value="CEROID-LIPOFUSCINOSIS, NEURONAL 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15014">
        <property type="entry name" value="CLN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040160278" evidence="3">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="314" mass="36753" checksum="55E68486CFE8F387" modified="2023-09-13" version="1">MNKFTIIILIIFLLKLTKSNPNEDLETFSCPFSNYCPNKTEVPIFEANQTIEMYFLQAPLLKPELNNTLAGLSLYHTAIGILEVKSNEQYFIEFDAISNFVNAVFPNLVNTTNSTKIIWCDTAHVCFSKAKIFPPESYFTNSTLIGKMNGKIFNDFMNWVFDYNTSVTSYQLFYAMELWPQQEYTPYIASQACYNFVWDSLYALNQLGAFFLPDLKLRHDFAILHTKPPVVVNPKDPQIHQEIVDFYTWFDWRNKTFEQIIKDIIFFIEDPKFLYVNGDYFLIEMVVPFVSAHYAVEELSFDSKKQFKFQSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEM8</accession>
    <name>A0A9Q0LEM8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gtp-binding protein rho4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEM8"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="156" mass="17636" checksum="827093137C32060A" modified="2023-09-13" version="1">MTRFKLVCIGDGATGKTCMLITYAKNKCDDYDRLRPLSYPDSHVILIGYAIDNHVSFNNVKEKWQPEVLHFCPKTPIILVGLKIDLRGDPETLERLKKRNENIISSDQGKQLATEINAFSYIECSAKTRENLKDVFQESVRAAKSRKSSGGKCILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFN5</accession>
    <name>A0A9Q0LFN5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFN5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="484"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="582" mass="67797" checksum="94A42AA212A0253D" modified="2023-09-13" version="1">MNEIIFFGRNLYPKLIKNEPDIITKPIQFKFENENENENEKQIKQIFSGYSGTFFLFKNGKLIQYLKCLDLNKNIQTIKIQIENIQKVSPGSNNVAILTIEGNVFAKGEDINPNEFINISSLIEDKNDRIIEDIVSGKNSIYLLTSNQNAYGIGSNQYGQLGLDYETFKETKPILIMKNVSKIFSGSSSIHIFLLNSNQELFGCGINYNSKLGLGESRKKEIKINKLTKIQNIPKGKIIDIQSGYSFSIMLIENENENPKRKLYSCGDYQCNGLGKDEDTYEFTEIKSPLFENDDGILDFSVGNFHTLILTYKSKLIGFGINDFGQLGNKDRNQSQPIPIQIELPELRFNKDIFNYHILCRNEKSFIYYSPPSFSNLEEDLIKLFERKEFCDISFKTKNGEIIKAHKLILKYRLNQNENQIEKLQEIISKKPIKESNQIFEMIYSNNSKINSKLYSEIKEIINSNEKIEETIKRIYLNENENENDFIIERKEKEYKFPKLILIMRSELYRGMFLSVTNDKSNKVKDYSELSNKSFQIFEYWIYSNQIKDGIQITKEIINEFKKGIDYFQLNQTNPNLFGFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGU9</accession>
    <name>A0A9Q0LGU9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_01647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGU9"/>
    <dbReference type="OMA" id="MIMEYQE"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="399"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5072632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68466" checksum="545D537EB4790DCF" modified="2023-09-13" version="1">MEKGNNLEIEFPKQIIPPDRKKTFIIHQFKRLILENKVKECEKHIENYSISHQLKDEKGNTPMHWIAENNLYNIAEMLIQKGFPVDTLNDDQSTPLHLASSKDYVGIVKLLIDNGADPSTPDDIKSHAIHVACQCNAYLTVQYLITEANISVDSPDDDNKQAPLHWASYRGNIHIQTLLLNHGANVNIQDSNLETPLHLACSQGFIDSAAILLNSGADSSLKNSFEETPFETAIQTNQTSVANFLQSKISKNQASPLYIPINQRIRVFFFIPILTLFICYLIFSIFSLAVSFSLIFIVTYIVGFNIQRLWKVQGELNPPRDPIRFGYFMGILLHLYISYYLYFIFISFKFTIFSSLLFIIFSAILPLSVYKLFKSDPGYLEQNKMTLSDALKIKKSLTQKDYCYTCKVLKPLRSKHDLFTQKCVARYNSYFGWCYQPIGFKNQIHYLILLFLTFMTILLYNFIIFTFIHQKYNFEKNGTFHFFNFESYFNLIKSAYQFHSWILAISLGSLFIGFWIFYLFFQSLFFAALNVTQDEFYSINKDSYLIKNGSFSNPFSLGWKKNLLQFFGWKFNVDWNNIFDLPNSQNIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGW5</accession>
    <name>A0A9Q0LGW5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High mobility group protein dsp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGW5"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="185" mass="22200" checksum="7D9F8AEA804E9D7A" modified="2023-09-13" version="1">MEKKTKDPKIKLEEPKHPLNAYLLFCADKREAILQSNPRITIGQLGKTLGAMWRKCNETEKEKYNQLAKKERERFEKEQKIYEQAKEIFRIESSSESSSEEDHRIQTRSQTREIRENEEKERIKRKIEKETKQTKKSPTGYLLFVQKVLPQIKKDYERLRVAEMGKIIGKMWRELPKEEKDVNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHE0</accession>
    <name>A0A9Q0LHE0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BTB/POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHE0"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="352"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="63937" checksum="2DDB7AE537254C44" modified="2023-09-13" version="1">MLNQTFSNYNKLSEDLKQLLSTSNRENKYSDFEIIISQAQKTQKTNTEFKKTIFKCHRSILSIRSEYFQGLFRSGMKESQEGCVELHSISPEIMESILGFIYTGNIKITHDDALEILIAFRQLLILDENLFDFLINYIKTNLDCNNVLQVLSFAQNFNFVDLYNICFDFIKENILGLIQSQEFLHFNPELLKNVLESDDLRIVEEMDLFNALVNWGKNQELLNPIVDSINSEKSLKKRIQDFIYLIRFCDIDQDNMKQIYENKLVSKKIKEEIKKYEENKNQNENENENKNQNENENQNINQNENENQNENENQNQNQNQIENQNQNQNQNQNINKMFYSRKILANISSILKNIENKYHRILRVWINNDDFLKNIELVYSAKRDGFNGLAFHSRCDGRGKSLVLYKTVSGFIFGGFTNKGWSKSADKNNASRYITDKHAFIFSLKSGKDPNRKPQKFCIKKGYEDGAIFYGMDHGPQFSIDIGLYQNERNPSKNYNILFSRFGYRYELPEGFKENGKEAQCYFAGKENDWGLLEIEVFQEKIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHS0</accession>
    <name>A0A9Q0LHS0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc transporter zip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHS0"/>
    <dbReference type="OMA" id="ANHNANE"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040132520" evidence="6">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="142" mass="15511" checksum="20A8EBAECBFCEB1E" modified="2023-09-13" version="1">MIAMILALTLSFHAFLEGLAVGITQNTGEALAISIAIIAHKAIEGFAIGINIFRAFRKSKFLVVMYVFIYSLASPIGTTVGIIVYNFHDPLASSILIALSSGTFLYAGTFEFTHILDGVKNMRKMMFSFFGFTIMAVVAIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHT2</accession>
    <name>A0A9Q0LHT2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Atp synthase coupling factor b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHT2"/>
    <dbReference type="OMA" id="DLTCCRF"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="688" mass="79482" checksum="E55148A40ECDD543" modified="2023-09-13" version="1">MNTNIQKRRRTRHKRITRQTQCEEITSVLSNEILNEIFIYLNIREKIQAGLTCKRWYHCLHSPKLWKRIDFSAKEPKAEMFPIFRDFDKYPIQFDCNPNVLFSVKKWGKSISSLNLKCCVNINEFSILNFLTFSTQSLKELNISFLDDITTKWTYRKLIYFHNIHTLHLESSFNLDDDSVDLIAKNLSFLENIFLDDCFLLTDSGVKQICRHCNKRLKKLSLNSCYLITEQILLYLTNCVNLRYLNIGNTQKFQFKNPHQENSYESSFEEKEKDNKEKKREKNQAKKRQIGNPKLNRNFNEAMEIVSTESNEMDTEQESEGDSYLIELAQNFGLFCKNLTFLDLSNHTEIDDEILHHMIQPMNALETIILDECDITDSTLAFLSEKNTNLRKLSVQSVSEISQEGISLLVSNIPDLCILNMNENEDLTDEIFKFLEDEDSEIFSHLERLRISSSKISDEGMKFFLDFETRKGFQSNIRELDFECCTSITDQTLIKLSENFWNLEAISVAGCDVTDVGVSAFAAKSPKIVVFDADGCRKIGTKGVSCLFENCNRVVAVALSETQIEDEVLNSIQKFSRNLRFLNISYCESLTDEGLFSLSNCASPLEWIDCRGCRGFTTKGVDEVTKKCLKIQMINVREIGELDPLILNKMKKRAKRIGIDMTIWLQENLISSLSSQTESTFSSSNNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHX3</accession>
    <name>A0A9Q0LHX3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Udp-xylose and udp-n-acetylglucosamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHX3"/>
    <dbReference type="OMA" id="NPFTGWH"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="343" mass="39713" checksum="916F952C32BDB787" modified="2023-09-13" version="1">MEFKLFFLFLQILSGCGINNIALEFILKLDSKCGIFLTFFELSSIAIVNLPRIISKYLQGKGAKIPFKSFLPLVGTFFLLSITNNIAYAFSIPVPLHMIFRSASLITNALLRFLILNEKINLKQLFALIFVSFGTFTASFSSYKLSKQQNINNINNIIIESEQKPGNFLIGVFFLFVVLFMSAFLGVLQEITYKKYGRYPEEVLYFSHSLSVPLFIPFYKNIYSHIKIFNKSKPFIFSDEMISIIPSFISQIPRLWIFFFINILTYHFCIRGVYQISSITDSLTTTFMLSVRKFISILISVLYFRNVFTFYHWISTILVFSGSIFYVIGKMENNQKKEIKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI68</accession>
    <name>A0A9Q0LI68_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI68"/>
    <dbReference type="OMA" id="CLQESTH"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="217"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="405" mass="48117" checksum="87F10B33BDD9EE9C" modified="2023-09-13" version="1">MEEYQENKLILKDVSKNAIEILIFSSKYLIDELIETCLKFIKNNLEFETVVDILKLSDLMNLTQLIDYSYQFILENFEEFIKTSFFLELEENHLNLILLNDYLFINEFELFQSIIKWGKHKSNINQEKENQKLEKEEKEKLQDQISNIIDKIRFIDFSNKELADILKEELIPNEISQQLIKLLIIKTQENENELNQFIEKQNSLIFKSRMKFKSSTIIQEKKQLKKLEEWINDDEFLFKMKLGYSTKKDGFDCKKWHDICDNKGKTLIIIKTKDNYIFGGFTSIGFINDKSKWREKDRSKEYGYIPDSNAFIFSLRNDKNDRKPEKFSIQKGKEQYAIWSYSTYGPCFAGGPDFRIETNLQNGYSNFGHTYNLPNGIEYGTNEARSYLAGSIDKWKVHELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI90</accession>
    <name>A0A9Q0LI90_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein rab-5c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI90"/>
    <dbReference type="OMA" id="FTKAQDW"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="217" mass="24098" checksum="50FC92E23AE5D2A1" modified="2023-09-13" version="1">MVDQSFQSTNSLNQLSSFHQLKLVLLGESAVGKSSIVLRFCKGQFFSNQEPTIGAAFLSQKIKVGNSMIKLQIWDTAGQERYHSLAPMYYRGSAAAIVVYDITSKDSFERAKVWVEELASQATSNILIALAGNKVDLENQRVVSYKEGEKYAEELGLIFCETSAKSGQGITLLFTDIAERLSTEQKQEQEPVESPTQKPTIQISNKSTKKVNKKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIU1</accession>
    <name>A0A9Q0LIU1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional dttp/utp pyrophosphatase/methyltransferase protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIU1"/>
    <dbReference type="OMA" id="VIGCDSV"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="235" mass="26519" checksum="6D9D83BE307E910F" modified="2023-09-13" version="1">MFLTKLKEFNKFDIILASNSPRRKELLESLKINFRIIPSDFDESSLDPVKFSTVNEYVLENSKQKGLTVMNKLNSENQKPDLIISCDTVISAKIEQEIPEDLKNNPVFLQIGDRFVMGKPKTKENSFKMLSFLSGKQHNVISGVTLLFPKFSSDENCITFSNSTSVFFKNLSTESINAYIDTSEPIDKAGGYAIQGLGVCLIEKIDGSWSNVVGFPLSEFCEKVSEKFEEIEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ26</accession>
    <name>A0A9Q0LJ26_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epsin/ent-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ26"/>
    <dbReference type="OMA" id="QKEEPRM"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03571">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="289" mass="34242" checksum="631F8FE712E3ADD1" modified="2023-09-13" version="1">MSWKKKVKKLVMRYDSSEIKVQDATTNSQERSSTSDLLEIAQDTFDSKKLPKIMKIIWDRLNQPNKNWKRIYKTLELILFLLKHGDEKVVDDVRLNIHEIRTLSNFQFVDKDKNDQGMNVRVLSTRIVNLLHNKEELNHERQVALKTKKTYKGISAEDNLKRIFSDEHKKRNEEPKDKDKDKDDDDKDDDDDDEDEDEDEDEDEDKDEDNDDNEDEDEDEDDDDDDKDEDNNDNDEDNDNDEDNDEVKVKDNDEVKNKITIKSQEKKIPKNSPLNKQILKITNKNENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ42</accession>
    <name>A0A9Q0LJ42_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ42"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="469"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68972" checksum="6792512CCCA9A79E" modified="2023-09-13" version="1">MNDCLFFGQNQDPILFENESFRITKSIQFKFGNENEKQIKQISSGIFSTIFLFENGKAIEYLNKKDSNQNPEKIQIEENIQKVTVGFQNEAILTIEGNVFAKGYNINPKNPNQFINISSLIEDKNDRIIQDVVSISNSIYLLTSNQNTYGIGSNDYGQLGFDSETLEKTEKPILMMKNVSKIFSGNSSYSIFLLNSNQELFGSGNNVYGRLGLGESRKEIKIKKLTKIQNIPKGKIIDIQCGYSHSIIKLYSTGRYFFNGLGKYKDTYEFTEIKSSLFENDDILEISVGCFHTLILTSNSKLIGFGHNYYGELAIEYTTENQLIPIQIELPKLRFNEEISNYHIFSGYYNSFLYYSPFSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQNEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQILEYWIYSNQIKNEIEITQEIINELKIGIDYFQLNQTNPNLFDLLIKKFNNQNQKKKKKKKKENCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ68</accession>
    <name>A0A9Q0LJ68_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein 4a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ68"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="273" mass="31350" checksum="2E1689241B4E30CC" modified="2023-09-13" version="1">MSIKITINTLTGEEIKVEMNENQKIKEIKQLISKEKEIPINEQKLMFDDVKLENNKTIKEYGIKNGSVLDVFFVDPQSSESETSIENEPKDEPKTPIGNEPKDESNDESKDESNDESKNESNDESKDETKDETKDDPFEVNENQKIQEIKELILKEKEIPIKDQKLVLDNNVLENNKTIKEYGIKDDSILNIFIVAQSSEPKTPIENEPKDETKDETEDETEDESKDETKDESKNETKDEENKKKPTETSPLVHDNVAKSKSDKKCCGCCRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJS3</accession>
    <name>A0A9Q0LJS3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Abc transporter h family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJS3"/>
    <dbReference type="OMA" id="FICAYLI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000032">
        <property type="entry name" value="Export ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF688">
        <property type="entry name" value="ABC TRANSPORTER H FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220">
        <property type="entry name" value="IMPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="70"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="376" mass="43556" checksum="81CD542098D2F1E4" modified="2023-09-13" version="1">MSLNQQYQEKELDLNINIDIDIENENENQNENENENENFNKLLINEKTPLVQSQKSNHQEEKNKSKDYIVSIKNVHKTYLIGTEGFAALRGVSLNIKRGEFVVIYGKSGSGKTTLLNIIGTIDSPTKGSLTIFGTKISPKTPDKILAQMRLNKIGFVFQSFNLMNIMNAVENVEFPMVLKAKETPSKRKQFAKEYLKHFGMEKRYKHTPSKLSGGEQQRVTISRAIANSPELLLLDEPTGDLDSANTNILLRRLLELNKNQKMTMVMVTHDINLKDFADRALWIRDGLIISEEIISEKRKKRFRKEILQKVDSQLKENLIENQIENQLENPNNFQIESDFEMKNKQSEFEIQPLNKTLFRKPNYYQYCNYVSSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK59</accession>
    <name>A0A9Q0LK59_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_07665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK59"/>
    <dbReference type="OMA" id="DCYILIQ"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5074961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="423" mass="49644" checksum="ABF3360E61541031" modified="2023-09-13" version="1">MELEQEKEINPWEIEKFTSEDNPDGLLEVSTFSVIFPKYREKYLQSIWGKVTQSLKAVKINCELDLIHGTMSVSTTEKTYDPYIILKARDMIKLLSRSMPYEQAVKILEDGMACEIIQIGKMVKNKERFVKRRQRLIGPRSQTLKALELLTNCYILVQGNTVSVMGDYKGLKQVQRVVEDCMNNIHPVYHIQELMIKRELAKDPSLQNENWDRYLPHFQKRNLKRKEKKKKKKIEKKDYSPFPPPQLPRKIDLQMESGEYFLSEKQKKNIEMEKKAQKKKQISEEKRRKFNQIFVPPKEEDFSNQSQSPSQKNSNPISKKKIDKIKNGFNKNFRQNINANSQQKQKNEINNYLIQVPQQDDLKQPLKKPKKSKSKQNSKSKSKQNSNSNSKQNSNSNSKQNSNSKQNLNSKQNSNSKWNIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKB8</accession>
    <name>A0A9Q0LKB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface glycoprotein (S-layer protein)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKB8"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057708">
        <property type="entry name" value="DUF7948"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052918">
        <property type="entry name" value="Motility_Chemotaxis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35580">
        <property type="entry name" value="CELL SURFACE GLYCOPROTEIN (S-LAYER PROTEIN)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35580:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25778">
        <property type="entry name" value="DUF7948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7948" evidence="3">
        <location>
            <begin position="112"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="721"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="850" mass="93098" checksum="A81C2EBF02399F4D" modified="2023-09-13" version="1">MKTLTILLIVFGSAFIIFASDIDIFFLQQTKFETKFETNLTKEIFNSFSINLSKNDQNKLHKKISYSKIPILILSNEDKLTNYPNTKYIARNVGRGKTTVYFTTESIDFFTKNYLIKLKMEEGNLEEVEAIGKGTLDTKITSMIGKDESQWKHDIKSYSGIVYRNVYKDVDLYFSVSKNGNLKSEFLVRNGNYEQIRTRYEMQTKNSGENQIKKDQNNGEIFYRDGCSEEEEISRCQFEFREKAPLIYQNGREIEGQYKVEKNVVSYLIEGDLLEKNKAILIDPEFSIYVGGSDEDEGMAAAIDVDGNIYLAGKTFSADFPVTSGAYSETLSGNSDGFLAKINSTGNGISWATFIGSDDEDQIVAVKLDSSGYPVVAGTTNMANGPSPFPTTSGAIITHCDANVTGFVTKFNLDGSALEWSSFLCADTSANINDLVLVNDYPVVVGKVFITKFTTDGSDFSAVNCFGGSDNDVANAITLTSAGNLVVSGSTNSADFPIINNGYNSRGTDTDCFVAKLSGSDLTTIFTSALGGNGFDYALDVATDIYENIYVSGSTKSDNLPATADAYQQAFSDNLNLFSGLVFKLSYNGIRLIYLSYLYGNFSQGQSFSSTSIATTTDLVYISGHGDCFSQYTDSYNFFNASATNTTAKGYIAVFDQVFFSLVDTVQLSEFFSSMNAYSSNGILVTGSTTDSLNATSGPFGEYFGGVFDSFIIRISPCDKGSYRPNAFSFCELCAVGTYKDSVGNNQCTDCIAGTYNPNLGSISADNCSLCPPGRVNPNTAASSLDNCLYCQRFYYAPDPGLTQCLACDSDQFSSISRTHCIDKLNASSFIHFGLSSLLFALFFLLFFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLB0</accession>
    <name>A0A9Q0LLB0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLB0"/>
    <dbReference type="OMA" id="QRANSHQ"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="235" mass="27709" checksum="6864404C7EDAB246" modified="2023-09-13" version="1">MSFFGSKPVCEVYVAFTDERVRKKITQTIKEQKHQLLVFTSGDSVGGKIKIQVKEGKKLEFEQIKVEFIGQIEVDIFVMNKKSMPDQGNPITMEVGIQDCIHIQFEYRKSKFHLEDVVIGKVFYLLSRIKLKFMEVSVIRREIIGKGEEIDYHNEIVSRFEIMDGTPVKGESIPIRFFLESLDLTPTYKKINNKFSVRYYLKLTLFDEEDKKYFKQSEIFLYRTHFDPFLKSNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLB1</accession>
    <name>A0A9Q0LLB1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc transporter zip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLB1"/>
    <dbReference type="OMA" id="EANRNEC"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="329" mass="36359" checksum="77D21F064498A896" modified="2023-09-13" version="1">MDEILLIKVISLLLILFIALSSGLLPYRFTSSKGMVVRYAEAMAGGVFLGGSLIHMLHGSEKILIQHGLYFPYTMLCCGGGFFITLIIENILGPIIKKRHNLPSSSFSFFDPDLIENEKTQEEDNLVQKENFNKDHQLSETSEDNKDPPKNMPEKPKNEKTEILSSGAEEFQPDPEVFLKQETISFRIISIVLFITLSFHGFLEGLALGVATNFHQALGIGIAIIAHKWIGAFAIGTSLIRAYRSNRKTVILYLIIFGTASPIGIITGIAIYNYNSPVICSFFVALASGTFLFAASYEFKNVIDGEKPTQKIGFGILGFTLMTVVAIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLE2</accession>
    <name>A0A9Q0LLE2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLE2"/>
    <dbReference type="OrthoDB" id="67296at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28653:SF1">
        <property type="entry name" value="ATPASE SWSAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="254" mass="29960" checksum="EBE662722C41E7CA" modified="2023-09-13" version="1">MIDLKKFIGMQTIEDFENNSQLFNEYCSLPKIKSLITFLIGSEECGKTSLLLSYSCSYIEEKEMDNQKNTSQQESLSEYQVIFMCQREKMEGSFPLFFQNHISSEKTLSKIKIIYIKNYKNILEYFLAINLDASNYRNSLFIIDDFSSYFTPKKDDDLFIKILSLIQNEIFHLNSLALISAEKEKIPHESIYSQFVSSILQIKSCQNINQNEDKSKIHFQLTFFNQEIEISLFYCVDFKQKLCFWTNIYSKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM45</accession>
    <name>A0A9Q0LM45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_07502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM45"/>
    <dbReference type="OMA" id="MWISKED"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5075151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="376" mass="42845" checksum="1B388272170BB21D" modified="2023-09-13" version="1">MDLDIQAFVIDNGSGMTKIGFAGDDAPRAIFPSIVERPRYTGIMMGMDMRISKYVGEEAQSKRGILTLKYPIERGIVTNWDDMEKIWHHAFYNEVKVAPEEHPILLTEVPFNPKKNREKTTQIMFETFNIPAFYLANQSVLSLYASGILTGIVIESGDGVSHIVPIYEGYTLPHAIMRIDLAGRDLTDYLMKILTERGYSFTTSAEREIVRDIKEKLCYVAFDFDEEMIISNKSSSIEKDYELPDGQVITIGNERFRCPEVLFQPSFFGMEQKGVHQITYNSILKCDNDIRKDLYANIVLSGGSTMFPGIEERIQREINQLAPPDIDVRVIDPPERKYSVWIGGSILASLSTFQNMWISKEEYEESGPLIIHTKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMQ7</accession>
    <name>A0A9Q0LMQ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMQ7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="160" mass="18600" checksum="50028F151AFF73BA" modified="2023-09-13" version="1">MPSWFLNFTFYSSNSPFYFHLHNTILPFISSIVPSILHLIHHLISIIIISLSVPSASPFRHFSISILDSSIGIIPSFTIPSASQSPLTFTIIIHNTSKISISINILHRHHQYSISIHHQYSHISIFQYFTIYSHFILFIINIYIRPSIFHHHNIHHFFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ99</accession>
    <name>A0A9Q0LQ99_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chascon isoform d-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="884"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="1603"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1416"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1887"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1987"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="572"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="966"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1422"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1439"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1528"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1548"/>
            <end position="1557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2431" mass="288712" checksum="F5177C091A46CCF4" modified="2023-09-13" version="1">MNQEQQQINIPEELLNEFTKEELEKMMRITLANENEKEQKILNKKRAKNILQKVIHEKSRIERIKNAELALKFYPKSIKSLVYLAQESTIPEECLRYLNQTIEMKKKKIENLKIDLNSLETHSSIISLLKMKNDYAWCLWKGLDNKEQALKEYYDILEISPKDPLGVRFYIMPILLSLKRNKEASDFYKKFPGDASTTWKYTKVVLKFQKTIENIKAKSRIKNYLLFLLESQKSKNYSSNYSIFNEIIKEQFQKNEPQFKLNYTMKEIQNELDTTQLTNQEIQEIKKIQKSNRKELKKKVYILYKLLQRAIAFNPEVPNIFLGKKNLPTHIFSNKYTEKENEAIEYIWNNHQFWLQNHRLMILLFFAFRKYNTKIWRKGEMRNEKGEMKNQNQIQNQIQNQIQNQNQNQNQNQNQNKNKNKTENQNQTENQNQNNTSNIQLKKDNHSINESNNVDQENQNSLFPPSLVIANEIENYFPKEFNENDYHLCNFQEIPIPTSVFEQRSAEPTHKLFFEMFKIESSAYTSIDFSNESDPQHSLKMYIIEAIFKKEFRQIEENFLQKNQKPNINLFLLKQNQNENEIENQNKNQIENQNQNQNQNQNQNQIQNQNQNQIENQNQNQIQNQNQNQNSNQIENIFKFPYISTISKTVTLLTQKGERLQALQKTQITDIIPKNKLENFINFFGCTENENKKENIKIRIIKKKMIDKFGTHFLMPAIQKVIEDDNGDNNNNNEIEHFDRLITESEKSKFEEENQVFWTSSDCPSDNEFDNEVKYNTEIKLDLNLDSNLDLLHHSTKFPNTNENTIGNRKFAKKVFSSQDPSTLIREKEVEIERFRRKSVAIKTGKQMAKDSKQYLQQNDWAPSLILYNKSFLNTPKYDFKRLSSILSNEALCLLHLKEYDKAIQICTRSLKFNPKNKKSLLRRATAFIESQQNLLALEDLYNLLRLDPDNEEANTLFNQIQILLYQEQENINLHQEDQINQDEQKNIINEKPYMDKLEEKIQELKEIQKFQMLNSLNQPRTMEELETIYQLQKLGNYHKIEKTQSNQENLKNQENSKNQENSKNQENSKNQENEFKDVDEKNLWYSISITPEILSQFLIEQWENQNIEKILSQNINFLENYIDKYFKKNSSRFMDFLLYKKKEEKEKDKEIILNKIKIKIKIKNQNQNQNQLRDRAQLISGNIEKLFIKFDLFDKFIVVPETKEQEQETQKKKQNINKKNQEYKLTISPNEISTKEKALELFKEISKFADINCEILFADGKINDITTKKIDNGKNSRINKEQLEIKLEQAQNTFEFFNSDLQEPYMLFLVFISKFFMIQLENEYKYYYAKKEHNHTFSFQNIIYEKQYKKEISKLINRTKKFIADKKIKIQKKINDYTFKIEKIERDEQLKKFQEEQKEKQRLAELEAEKRRLEKIENKKQKLKRKKQRKRNKRNKDANQNANQNQKQNQKQNQIQNQKQNQKQKQNQNQKQNQIQNANQNQKQNQNQNQNQNQNANQNQNKNQNQNKNQNKNQNKESPQIAKKIKSLSNPNKKQQKQNRLQIVKKTKSEPVKKQENLQNNTNKNEDPNKELQNNLLSQLTNEEVDELTGYYDLDKNFCHSKTMWIGDVGEEFTEQKLEGLCSKYGKINSVKVIQHTHCAFVNFNDFRNLVIAYKDIKGKTINGMVFNTMNIAKPHDSADPDKKIITSEETRQFINRFPQDAVLRLKNLPFHVNPNAIKSLFNNYKICSNGIYIIKSKLSASAQCFVAFINHYEAISALKSRAYFRMNWRNVYVSLVTDSDDNQSDDSTISKFKKKENEIKKENEIKKENEIKKENEIKKENETKKENEIKKENEIKKENEIKKENEIKKENEIKKENELKKENEIKKENEIKKENEIKKENETKKENEIKKENGNKNKNEIKENEIKKENEITRENENKNKNGNELQKKTVSETKQLIIDRLSNLKKLHFEERNKDSKIGVFERNISPVNTQYQTRFGNPLNFNLNQNQNQNQNQNPIQNPIQNPNQNLNLNLNLNLNPNFNQKSQELDNQTKFPFKFENGKQSLQDSSKFPEKFVDFLPDLKMNFPQQKSNLEIFQKIHQESFKNNSEMKKDKKPNINMNNFGNTFGNSYNMNQSIFPNQAINNSETNFLKPQTIIKNPNSNIQTQTINNNINFSFKSLNNNVYNFINFDPNNSIKTRNENKIPNLSQLQSQEKTTTTNNYSLEKLVDSTNTEKTKEFQNNFFDDPNLNFSNIGNFFQNPIQNSIPNPIPINKIQNPNPIPNPIQNPIQNPIQNSIQNPIPNPIQNPIQNSIPNQIQINKIQNPIQNPIQNSIPIQNQIQNPIQNPIQNSIQNQIQINKIQNPKKNPIQNPKQKFFLNLNESEIQQKKTNELIKPQKKRLNFDQSLIEERSPELNSIEENSFIENSPKLQKQKMNNFLINNFQINLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQC7</accession>
    <name>A0A9Q0LQC7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQC7"/>
    <dbReference type="OMA" id="IAWANTE"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16484">
        <property type="entry name" value="RING-H2_Vps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="640"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="864"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="911" mass="107329" checksum="14EEC6D821F880EA" modified="2023-09-13" version="1">MSSLFEKKSQSSFIEENIEEIDEEKIEKAPILKYQSLGTFHLENEGEKDNLSQRICSVKIFKDNLIMGTKQGQFFQLPIDDFAKFQPKIKGDSLLIDFSIDDQNLNIATCFANGKVHIFEMNQEEDKEWKKEKTFDMNHQTTAIAINPNYDGKGGLFVCGIREEKNRKFIRAKVIYQEKKLFSGQTTLYSGNGEINAISWKGDFIAWANTEEGIYVYNIKNQIPICKIPIKEDCLRPLEKYPCRMKWIENNKIIIAWANQIHELIVTETNEYNYKLVKTFPFIICGIAPYNDNYLMLTMQNLENEMEDPKIKDLFDRFEKEFKHIIEKPEPKEKRIEEEESKKNVMKDLFGEDAKKLLEEQYCPIPDMRIITKKGEIIFEESIMIRGYEFCSPLDLGLEAQPNPTEQKTRTMFFLYSPFQLLEATERNIDDQITWLMERLRYSEAFKVAQKNERQLKKYNVTRIGEVLLGSLLVSKDPMQIREAAKICPIVCADDQNLWVRWISQFFQFQQFEEICPYIPIDHPRLQEVIYEMILNNFLENDNLDLFLQTIRKWPKNIYNQKSIILIIEDKQKEINFLDERLALPLADLYLEVGQYEDALTIYLTLERPDVFEMITANNLLDSISTRISDLADLDERQTITMLVNNTEKIPIKTVVEQLETKRKLLCEYFKNLSKKDPQIVKDYQFEIIKLTNEFDPQNLIKFLKSSDYIPLEEALTYFKEHELFRESVYILKRMGNTYEALDLIFHKLKDMEKAIKFIQHEKDPHLLRKLVSYCVNEPVHFPPLLKALFDSNFRLEETIRRVPEQKVIPGLGDSLKYIIENFQRNVKLSNLATDVVRKDCGELMHSLHTRMRMGFRFNHKNSCPICNGKISQIEPFVSFFCGHTFHLACLKENIRDKPFCTVCSSRQRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQR1</accession>
    <name>A0A9Q0LQR1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQR1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="262"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="636"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="669"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="893"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1026" mass="118052" checksum="F8876099F792E31B" modified="2023-09-13" version="1">MDIWEAIEQNNIEFLNKIESIPENYQKKEGKPILNFAIKKQVPFEIIKVLIEKGANVNLIDSLKRNSLHVAVINKTGIDIINALIKANISINAKDIKNQTALHLACQSSSLEVIKFLIENGADINQKAHENTTALHFACQSNSLDVIKFLIEKGFNIKEKTYGNKTALHFACQSNSLDVIKFLIEKGFDLNQKTYRNESALHFASQSNSLEVIKFLIEKGFNINEQTYGNETLLHLACQSNSLEVIKFLIEKGFDINEEIYGNKSVLHFACQNNSLDVIQFLIEKGLDMNEKTEISETVLHFACQSNSLDVIKFLVEKGADVNAKTYDDKLPFHYAITNPSSFEIIDFFISQGVDINEPSFGNENILHLAFKENPSFELIKFLIEKGASLDQKANFSGEKPLHYTVKNPSIIEMIELLIEKGANINDKNEKNETLLHLVLQKELEFEFIKFLIEKGVDINANSIYNETALSIAFSRRYPKEVIEYLISKGADINVKTERNDAALHIAFQNNYSIEMIKYLIEKGADVNAKTKRNETPLHLAFEYNYSIEIIDFLLSKGADVNVITDDNETILHLICQNNYPIKYVELLINKGADINVQLNYSKKTPLHLAFHNDYSIDIINLLISKGADVNAKTATNETPLHLACQKNLFEIIKLLIDKGSDINAKTNQNETALHLAFKYQNSIEIIEYFINKGLDINEENIHGQSCLSLAIQNKNKKGIKCLLMNDANLYSLKVKTISNDFIHLFSKIYSINEDMSSFLISKNFSDFVIECKNSLKISAHKLILLARFNNDESILQKFVDICYQKFKADVETAINFLYTGFLDFEQLKQQFKNQPKTKEKQNEQITLWNEKKEEMEKIFKEIGFDSNWVNSKKGRNGLLNDLKLLYKQEETKDFTIICEEDEKEKEIKVHKLILIIRSELFRGMFLNVNDSSNQVHDYSGKSFETLNQLIYFFYHDEFDESKLNQEVIEELEDVKNYFQTNQNSKLNLILNRLKKKKNIITSPYIDRKENQEENQESFVPFDFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRF3</accession>
    <name>A0A9Q0LRF3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRF3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="66" mass="7686" checksum="8200C2568E812135" modified="2023-09-13" version="1">MEDLVENYRASMILGAVVFLVFDFTLLSVHFSFLFGKKITKLDHVLFRNESNHFTTELILNFLSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRI4</accession>
    <name>A0A9Q0LRI4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRI4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5078501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="379" mass="43903" checksum="BCB941A820D61809" modified="2023-09-13" version="1">MDEDEDEFLNIIMDNGSMLTKAGFGEENEVRSVFTTLVKRPKNRSPFLGINSKEAYIGDEVWLRRGTYIEKYPIQNKMITDWDDIEKIWFHTFYNELRIDPEDKTVILSEPSLNRKKIREICFEIMFETFSPQFFWMANSGFLALLFSEKKTGIVIEFGYSQMYIIPIFEGIVLDHAVVKSDFSGNDINDFMTQILNKKNYNMITSFEREIVRDIKEKLCFVSFDYENDKEISEKGGFNKKQYELPDGTDILIDFERFTCPELIFQPNLIGFSQSLSVTGLIEKSISKCDIEIQPILLKNIILSGGSTKFPGFSERLKKEIINSFGKNFEVEITSPSNSTYSVILGGFKLSKMSSFNNIKISNQEFKEFGSSLIYHKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRV8</accession>
    <name>A0A9Q0LRV8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G protein-coupled receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRV8"/>
    <dbReference type="OrthoDB" id="5956805at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040239106" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="884"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="934"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122334" checksum="7148BB9EFCB98696" modified="2023-09-13" version="1">MKNSKIFIITITILLIFTKKVESITTLYVDCTTTNTGACGDFTTPCGDITSALNLIPENGTILITSATCSGTGNTNITTSKSVEIACDAETCEIGCANMDYGIVANYTGSTGTLQLNKIKFQNCLISTGSTTSAKGAAVHVVNGNLNVSNCVFWRNQVSGTATADSSVLFSGSIFVENPNFVMIQNSQFAENTNDVSGASSIGIVSNVSGTTSPQIQIVSSSFTQNSGQIGSVFVEAVGSSSDFFLDILDNSFANNNGAQSGVLLIDNDLLQRVFQANITGNVFQNNYGNKTGAAEISTSNLSTLKANLTQNIFANNTGNAKSGAVTMQINLAQDMQYQIINNTFDSNLGHKGTIGFFVGYLSNFAESISAMQNTDIVFESNSFTHNFADFGGAIYIETDSDLSLSKNTFANNSAINAGCVYISSNTTVVESESVYENNTAEQSVAMFAFTDSLVTIRNNMYKAQIQDETFVEILSPKTPNWVSNNSVKCPSNSVVTINEEVNFEQALEHSFGCDVCLPGTYSFPLASSSITAGTCFDCPAEAICRGGMDIRAKSGFWGTQLDPAKKDITFFFCPTDYCSNEDSEFAQYSHCSGNRDGTLCGDCKPGYTETLRMHPHCASTEKCHTQIAQFLLLLLPKVIIYAILLLYIPQLKSASFHIFPFIDILISFSQLVSLQTNLEIFSDFAACPSASPINSAQKMAMQLVGPFTFFLAVFAVYFSILIFTKIRRAKAAEKLSDSHSQSDSDNDPKKPKSNDDKDSDIDSGIDKPKEPIAPKIKTKSIVAQINRLEAQLVSDTNPAEWQRAEKIADIRDNDVPSDDTSSLSTLPNDQDLSDLDPPDIANLIRIFPEIEKLVNEDVRREKIIQIAEEEAKLFPSQSLTKRLGISLLTILFLSYFPILNAFANLTSCIKIPYENEPQRRIFLFASVSCYQGWQIFVIILILILVLLPFLLFWILRRKTISKNFLNWRNSFYFPFRERYYWFSCVMLLWRVVLIFANSYANNNSLRVFLITSFSLLILIAHLQTNPFLLKIHNRLQTVSLFILTLFSAVNLIHSTWSYGGIAPGKQAMDIVGDVFRYFLFVASFLLCCYAIFLFFRMIFKSILFSKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSC2</accession>
    <name>A0A9Q0LSC2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSC2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="286" mass="34470" checksum="00F86F553C75DE4A" modified="2023-09-13" version="1">MDCFMIFQILKIQTKFDTTYEKEIKFGCQIGDSTISKVWNLGLLGMQKGGQRIICSHPKFHFQYQYEYERMFKQKFSENSVIVYFVDLKELIPLNQIKNDQNEYYYDNYFSFQPTEQVMLDKNDPFQFNQFNQFNQFNQFEQFDSKEFPLIENIQEHENFENIQKHESDEKTQNKIYDNIFETDEINNLNEEKKPKEIPQKEKEPKQIFIQQNYPKQPLMNINEILDLLIDTRRNGVDSKILINSLSFSFDSISQKIQQFLHSIQKMENQSDKSKRNQSLNQKLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSJ2</accession>
    <name>A0A9Q0LSJ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSJ2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="221" mass="25210" checksum="CD1EC08BDC2C08C7" modified="2023-09-13" version="1">MGIIFKMGFAYGLVSILLPGRVEHDLRDTVVSIFRVLVDISCKTGISSSNTPYIGALASFLTTKEITELRTRLGRYLEWEGELEQIFFGYLVHQDKNTSNLSVYLFTTMLIQSEYDQHQLFILDVLVTAIDSFPESFSNVHHLILPKLLNILSQTQNIHVQKSALKLTDFLLSSNFEKKPEVLSNLGFKNLHKFIGFSEISYDREQRGKMISNIIEVVSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT69</accession>
    <name>A0A9Q0LT69_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 26c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT69"/>
    <dbReference type="OMA" id="CVTMPIT"/>
    <dbReference type="OrthoDB" id="10263384at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="297" mass="33262" checksum="129449D8738E925C" modified="2023-09-13" version="1">MSIEIKLKKMNRTYTIGEKIVGVVYVRTKKELSHQGLILIASGDVGLQTTTRTSGLFEAISHSIKPFNVSYCSLTLLQPGKIPSGETELPFEFVLAPKKGEELVETYHGVFINSVYTITATLSRGRFGKKIQGKLEYIAEVPTLKKYKPTIASFTISPQAIENVKKSSIDKIPKFTISGQIDNLICDINSPLTGFLVVQSTEFPLRSIEVQLIRSETCGTKEDGFMKEDTQIQNIEIADGNVCPQMKIPIYMKFPRLFTCPSLSTSNFVIDFEINVVFYFIDGHILSKNFPIKITRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTT4</accession>
    <name>A0A9Q0LTT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26s proteasome non-atpase regulatory subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTT4"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="3">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="389" mass="45750" checksum="CA8DEE7241C61194" modified="2023-09-13" version="1">MENKNKITQKTSQLNYTKKKTIIIHPLVILTIIEDYMRRSNSEAIGVLLGFKRKNLSENQENLIENFNSQNLSITEITNCIPIPYKNDEKTKELLEHREKLFQKNRKKEEKQNENSNQNSNQNSNENSNENLNQEKNIENNKDKQDQEKSSQNITKTNQDLESDYIRSKNYQIKSLLEMLKFHKETFKNEKILGWYSTTPSPILIKDFLDNNSLKSNNPITLTLNTKKFTKENNPQIKVFQVEVIQFANEILGTYFNLIPHYFSSLNHQRNALSMLISDQNEHGVENIVKSTPKKQLEIMVKNLQKKIDKIQNQVNNLDVTILDELKLNQMKNKFKYSFMEIIEFEKKHLMEKEIERVLSDDIEDSLMLTYLSQLIESQTILIEKLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUH8</accession>
    <name>A0A9Q0LUH8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUH8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15265" checksum="1D2BF932FB27CE60" modified="2023-09-13" version="1">MLNLRYHIFSKLTTKILKLNFGRKISSSINLVIRSSGVEVESSQKTTRCTFVSTLRGDGEILPIYYIEHRPQTILNGQIWKKAIKGINVELFVDYICKTLSNVDKKKPKLFLMDNLKVHHSKGVLDKLANLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUL2</accession>
    <name>A0A9Q0LUL2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Armadillo repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUL2"/>
    <dbReference type="OMA" id="AILQCML"/>
    <dbReference type="OrthoDB" id="201709at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042462">
        <property type="entry name" value="ARMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="179" mass="20610" checksum="24EBACD813896C13" modified="2023-09-13" version="1">MFSSISKIRKRNQSGEGLNRLEFLKQLVKEYKETKSEKSKIESLAKLGNFAYDPVNYNFLRKVKAIEVFVQSLKESNQKLIELGIGSICNCCIDPYNLIIIEKEDGPSLILECLFSENENIIQSSLSIIFFVLSCFESHKFKFDLKIQERINELIRSQNSQTKNLSSIVNDLIESTKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV33</accession>
    <name>A0A9Q0LV33_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_05515</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV33"/>
    <dbReference type="OMA" id="GIGIKCC"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="146"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="328"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5077825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="527" mass="60211" checksum="8D9E0EFD3BA2F9AB" modified="2023-09-13" version="1">MMENNKIKRLKPKVKPKLKFSQILINDLEKPREKQTEINQEFEIEKQTEFKKQIENKNVVKINGLKENEMNRINKIKENEMNRINKIKENEMNRINEIKQNEIEDKKPNEEQKGDNFEELGLCPQLVQACKDIKFQKPTEIQQQAIPHALKGRDIIGLAQTGSGKTAAFVLPILQFLLETPEPYFACIISPTRELAFQISEQVRALGANILVKCAVLVGGIDMVSQAIALAKKPHIIVATPGRLSDHLENTKGFNLRNLKVLVLDEADKLLNMDFQESLTKILKMIPKNRKTYLYSATMTSSVEKLQRASLINPVKVEVCEKYSTVDTLIQQYVFIPNKYRETYIVYILNELVGNSIIIFSTKCQSVQKIALILRNLGFKAVPLHGKMTQTKRLASLNKFVSGNADILIATDVASRGLDIPNVDIVINFDIPVTVKTYIHRVGRTARAGKSGRAINIVTQYDVEFFQKVESGLGFKMKEYTLQENLVLSLYERVLEAEKHANKELKEQNLSRKRQNRSKKFTKSNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW77</accession>
    <name>A0A9Q0LW77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Intein-containing atpase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="300"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="922"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="505"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="671"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="787"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1533" mass="178101" checksum="20E7E47F85FF96BA" modified="2023-09-13" version="1">MSSQKSKSNKKKRNKKLKKENQTNLISVPSIEESQKEWKIKLITFLKQKNNQKINLNLEEARKFHYVYINPKDMISHSVTTNTPLVLMNTENNRMVVMNSKPNVSISSGNIFIANEDDLLNLGISRQKSQTTGVESHAVILEHLSSKHQVVQASKITLIPESISAKILFSGKDSNPETIKLSNTYISQTLRDRFVMSGSRLSIFLFGSNRIFLMGSTKPKSHTIYEITNKTKIVVKIDSYKFLKNQKWNTKYYQVKSDELEGFGGLEAVGGLESQTKTIKEIIEYPVKFPEIFSMFKIRPVVGILLFGPPGTGKTLLAKAIAKDSKRNVFVINAPEIAGQYYGESEQILRDVFSSARSKSPSLILVDEMDTIFPKREAAMNEAEKRIVSEFLIQMDQLSSNYDHHQFDPKIHNSENFHLQNVIVIGTTNRIEAIDPAFRRPGRFDREIELGVPSEKEREKILTILLKSIPNNLSEKDIKYFAGLSHGFVGADLNFLIQEGCLNYMKRIKRKKEENKNQKEIKIENQNQNQNQIQNQNQKEIKIENQNQNQNQNQNQNQIQNQNQNQNQNQNQNQIQNQIQNQNQIQIQNQNQNQNQNQNQNQIQNQNQNQNQIQNQNQKEIKIENQNQNQNQNQNQIQNQNQIQIQIQKEIKIENQIQIQKEMKIENQIQNQNQNQIKNQKEIKIENQNQNQNQNQIQNQNQNQIKNQKEIKIENQIQIQNQNQIQNQIQNQNQNQNQIQIQKEIKIENQNQNQNQNQNQIQYQNQNQNQNQIKNQKEIKIENQIQIQNQNQIQNQIQNQIQNQNQNQNQIKNQKEIKIENQIQIQNQNQIQNQNQNQNQIQKEIKIENQIQKEMKIALESKDLKKAIQKIRPSAMREILIQVPHVNWKDIGGLEDVKQKLKESIEWPIIHPQAFERLGIRAPKGVLLYGPPGCSKTMMAKALATEAGLNFLAVKGPEIFCLSSQTKILTDHFGLINIQDLYQKIKPFSKKLPSNFSSGKKARQIIDLEINTLSFGFCSQNQKFDFHKFGKIGNSLNNFKSKIYKIYKIWTNKVFQITLENNAKILCSKNQPLICKSIDGFKWETVDNIKQGDEILIINSFPKFQPKKINSEKVDSFGFPFVCLVGWFFCCGKMNLIQKTISLSFSENWELKELIKIIKENNIDKERMIISKSFIEFRSEKIVEKILKIFGFTKRKDQNPIFIPKETHISKFINLNLLKNLDQEMIKIFIRSFFKNFSNNTKQTIFWQTKTRLLMISMIYLFQISQIRILRMDFNKLGIEFQNPKFGGCDETKEKLYLNEQLRTIEVIEKKQILSQYLYDLETETGDFVGGEIGIPLHNSKYVGESEKAIKKIFDKARQVSPSIIFFDEIDSLGAKRTGDEGGSGVTDRVLSQLLNEMDGINDLRNVTVVAATNRPDLLDPALLRPGRFDRKIYIPLPDFDARCKIFEIQLSKIPHSSDVDDLIPKFAQDSQNFSGAEIVSVCREACVFAIEENPNALQVLPFHFTKALKIFIPRTPKELIDYYEKFESKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWC8</accession>
    <name>A0A9Q0LWC8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000052">
        <property type="protein sequence ID" value="KAJ5078638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWC8"/>
    <dbReference type="OrthoDB" id="2406744at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040250828" description="ATPase dynein-related AAA domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23904" checksum="1BED2D0EB11451E7" modified="2023-09-13" version="1">MMIGIILSIFISYGCRFSVNLRSDYYSYILQDIKITPFFQNLKPAFPTTTNEFLEAINQLRTQFFRNIDDKSYLKSQAIAANEALTENLLVEFICIQTKIPLFIIGKPGTSKSLSIDILKNWLSNSSNNEYVRKGKLKRIRVFPLQCSPQTTPRAIEKIFEQARRYQQQQKDYLENLKIKKIKKIKNFKNFNIKEKKMFQLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWK6</accession>
    <name>A0A9Q0LWK6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000014">
        <property type="protein sequence ID" value="KAJ5080080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWK6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040175062" evidence="1">
        <location>
            <begin position="21"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="669" mass="73941" checksum="7AA7AAF74BB48FF7" modified="2023-09-13" version="1">MNTFLLFFSSLIFLILIVKPQITPSNSFNFPLGISSPYVSLIDVDEGFVYFADYDYKTLYKFNINTLQPVNVLDLEIHNIQCGVIDTVNKFAYFGAYTNPNKIAKVDLKTFTVVDILTLSTNGDGVWTGQIDVVNQKAYFAVNIIVGVVKIDLTTFTEEANLTLNTSNQNFWGSAIDIPNGFFYVFTDCCTPVGGTPVISKIDLSNFTEVGSLALDSSEAQPFCAVIDSSTGFMYLGTNSAPMMIVKGTGIDIDNELAYFVSRSKLLVKINLTDFTGIDSLSFTFTPNSMSVDLNIQKAFIGLSEIGVSEVDLTVLNQTDQIIVPNCRYPSVILVDEPNNIGYVAFSNGVGTIAKVDLDSFQLVDFLNTGVSDSFTGGEIDSTNGFAYFFLSSSGLGAIKLRLSNFSVDGVIILDSNCSFIVSAFDNQNHFVYVGFDNHTSNVSTLSKINSPNFEIVDTVILDNNEIDYLIVYSSKGFLYELLKVSGYFINQVALSNLSEVIDSTYLSNYNVSVIFLDSNHQYIYFGTDATYSEICRLGLTNTELFYCLEIEGVNNFVGSFIESSQTYGFFVSDFLNNETGEYETRIIQIETISNQLLSNTSIGLYLNGFIGVYDSTSRYEYASGYNNYPVPFIQFSVPNPPNPPPSSSSEILFSILIIGLMMMILQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWR2</accession>
    <name>A0A9Q0LWR2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calnexin 14d-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWR2"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040533482" evidence="5">
        <location>
            <begin position="20"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="332" mass="39264" checksum="EE60E3BABC10524E" modified="2023-09-13" version="1">MKIIYYLILLLFLFHFNLQQNLQQNSNQNSNQNSNQNLNQNSNQNSNQNSNQNLNQNSNQNSNQNSNQNSNQNLNQNLNQNSNQNLTKNLDQILKENFKKFHQNLNQNFFFLETFENFPNNKWISSQKSKYKTKWKIELPKEPYEVPDDLGLVLKSYSTFHAISTKLPKIFDLEKEGIIIQYEIRFQEPIECIGGYLSFPSSINFQESLFDNETDLSIIFGAEICGFFLNHIKFIVFFEDQETKRIERRELIQVLPITLNKITHLFTLLIEKDANFKIFLDMKKILEGNLFSNQLFSSKIIENQLENQNQNQNKIQNQNQNQNQNQNKNQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWU0</accession>
    <name>A0A9Q0LWU0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWU0"/>
    <dbReference type="OrthoDB" id="4136242at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049232">
        <property type="entry name" value="DUF6829"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20717">
        <property type="entry name" value="DUF6829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="763" mass="87168" checksum="E73F9721F3225D22" modified="2023-09-13" version="1">MEKQNDKKNNKLSPFIKSIKNLSMDSFLSQVIDLYPEINWLMNDCEHSPDYNKSSIYSNKRPSIQINGKPSIEFDRTVIGISCIKLVLDRNYEAFVETQNEEKKLTKENFEQLCNYVDSILNQDEDKIDSLIVYIAINDLGKINSFVEKVKSHLQITEIANHDEILFLALEKCSEFVPSFSRLSEKFQKMILNTSMVECNIGQITQAEAPEYPLTQLSSLTEEEYHFFMIHFLFDISGAAGHIFPFGSFVVSNFFWIRFYTLNNLLIDFFKSSFSDVEDIYSRYLRKQIENFNLNQNENENQNQNQNQNQNLNQNQNQNQNQNQNQNLKIHALSRIFLLARLSTQQEFDFVCKSFDQQHDLVKEILIQELNISGLSQKMAIIPYYAPALINSILENEKANGKGIQDGLNIVLLTLARIFFEVRLGILNKKNNGIVNANIRKLALNSSKILTSDFGVNWITNHDAEIFFVDFTKIDHQNFPIKPTLSEFFTDEKLAVIGIGGGSDGVQAGLLAHLLKKQGKQIECLISVRTGIQGNGKERKVENHGGMIYKNVYKINPTSGGSGRFLENIPSIDFPMYLVLDFEDEQLTDQIQAVLNQYKDLKTLISVDTGGDCLYPFDQDVAQVKATPDQDLRVLNALSKLSNEIKVISSVIAAGIDSPPNAEEILHKSNAEYYQLDDKEANFVVQKYIDWGFDSSNEKIFGLTPLVWKKSLQNDLGLQVVSLPKNVVISDSPWKPFVFVRESMKGIFFMKLEDHLKQIKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXD4</accession>
    <name>A0A9Q0LXD4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000003">
        <property type="protein sequence ID" value="KAJ5080732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXD4"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="59020" checksum="8923B81267F80975" modified="2023-09-13" version="1">MSDKENKNSLKEPRFPSYSFFEEPQKFTQTTGYKVRIRNLDFEITNTELKRLLSSDGKIKKVNIKFDRSGRSKGLGYLYFYDERSAKNVIHYWNNRIIRKKPISLEFLGFVTGNDVPNSRSSDDWRKDKIATWNENKTNPEAQLSRSNGDWNEARNQTWRLLRQEEKEQEFNSAKYSEHKSKKHSKKSPKRDYNQSYNRRRRKKNEESLSKSTSKSSSKSLSKSLSTSKSLSKSKSKSKSKSKSKSKSKSDSEKYKHYNSYSNDTDSHSKEQYRNLYKNNNYQKQNLINKWEEEYKREIQQYDPILNQMEHIEEIQITKKPFELPQTKISQNKTSNQNEIFQKLQENANRNDSNENYNENFKSNQVVSYGLKEYLSRRSSNPKDEKKRKKEIDEVNFDQVKKRQLLEGNESKSKSKSKSKKSKKSISLSSSSESSESSESNEKKLRKFRDHLTWKYKQKLKQKMKMKKKEYIHKIQEKCRKKKKQIQSMKNQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXE0</accession>
    <name>A0A9Q0LXE0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Solute carrier family 35 member f6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXE0"/>
    <dbReference type="OMA" id="HTIHTYE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5080371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="331" mass="38529" checksum="4CAF4A1B7AB3351B" modified="2023-09-13" version="1">MKQKFMPKSVSFILICIFGTATVCLSKASFQFSSKGTNSEHKFEKPWSLTDLVFLSSIFLLLIDKIGKCCDKKNQNYQQLPIYRNQKQWKIFLYVIVPSIFDLISKIFLFVALIDLPAGIWQIYRSSIIIFSGIFSLFFLNRKFYIFNWVGILFIIFGLLISLFSEYMKSESDKNSKLVGVIYVLIAQFFLSIQSILENHLYQRIYISKMRISGLQGLFSFILTSAIISIIYFAIGTENNGPKEDIVDTFHMLKNNHNLLYVVIIFFVTSLFYQFSSIHGSLSRSSRMIALAECIRIILIWVLDLIIHYFWSDSFGVEWKSTYSYLQLVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXW6</accession>
    <name>A0A9Q0LXW6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein derived from transposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXW6"/>
    <dbReference type="OrthoDB" id="2162928at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="577" mass="67787" checksum="C77A568B1039D868" modified="2023-09-13" version="1">MARCKKNSNKNPKKTPKVKSKRRNYVDIPWKKIFEKVEEKKRGSITYYAKKYNISRSALSTRYWRWKREKPMNENTKDGRVEANIKNKRILKEDDENQLLELIRDDISAGESITPKQIGKLAKSLFFSSRKKSINSSWIYRFMKRNNLTLRQACIHEIFPDDFDGKKEVEEFLEMTKDLEARYSHSQVFNMDETHIVFEPEIKKTVSEKGKKQAQIKSKGNPKEGCTVVGCIGADGKHLPLTFILKGGSRVIKWIKQDISNTNLKGNCTFFANSKSWMTRTVLMKWFKEVFLPNTPTPCALFLDHFKVHEDKTFIDFAFKNQVEVFFIPPHLTGQLQPLDKMIFRQFKFKYQDELEEEILSEDSLRIKRLKVTKACFSAWNKIEAHLFARAFRKTGIIHDNLDSFDEKSVMDFIETHSVKKIEATEKENSNKEKIEEKNESVPTKLNLEMEIVNSDEIPQTHFEEVPIKESFDCKKTNNSKNQRSKKILLKRKIIRSILKRKLTLTQIPPKIGFEKDSSIEITQNKFGYEENTEPNGEDNQELFPLIKRPMNNFYHSQSPKKHQWEEIVLDNGIFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYI9</accession>
    <name>A0A9Q0LYI9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYI9"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="300"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="486" mass="55794" checksum="9C9AFD4BBA567CA4" modified="2023-09-13" version="1">MTKIFSSYLKLSNDLRNLLQNTNSHSDFEIVITRKSESPKIYRCHRAILSCRSDYFNGVFRSNMKESQEGRIELSDISEQFMENILTYMYTGQYEISLENAIESLIISKKFCFEELAEFSTTFIKDNIDTESVADVLNISIQFGCQDLYDFCMKFVIQNFHDVSKSSTFANIAEHELSEIIASDDLTSLSEQEILQAVIAWARKQLNMETTTLPHLQVFQSIREKFELLLNKIRFCEFSKHEIQEFVQAGLVSEEIHSLLLDFFTIRDVDEDHVKLENFKSQLPDSQSLIFEERIRFPRSLIVKNSNLYMGKLREWIADLSFYRHMRVGFRASVDGRDATTFHSKCDNKGKTLVIIETTEGSIFGGLTSIGWRSGHAHNYVRDENAFIFTLQNPSGSPPQKFDVQKNNPSAGIRDFSDTGPIFGGSNWDISVNSTLTSGWTNFGGGYQLPSNLETDSISAKEFLAGSFNQWTIKELEVFFVDKRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4K2</accession>
    <name>A0A9Q0R4K2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4K2"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="387" mass="46274" checksum="61CF5CFE3CF5228D" modified="2023-09-13" version="1">MIGFNLKNEKDKNEGKVKNGYYNENRNENENENEKIKNGMELVIDNLESTNEDNKLLTRHIMILCENIVILPIIIEKIKDKFPKQKIKLLYGTSFNEDKKIQTYQDLKNIANLISEPNIIILCNQEQLFEPLYDVLNQKYTFIAGKLFSHIIFGASTTRVNIHPLSRIIVIMEKERAYQNLSIAVLNRFEKQFITSNDFLNSTGIELRKQLRKNFKNIENITKTKTITKTIREQELFKGYSENLIDSLSFKLQQKQKQNENENENENENENENENQNQNEKEKEKENENQKENENQENQNQNEYLIKKLKIQKQNEYENEYEYDIIQNKFWNKNEYEYDIIQISNFGKRSEFEKEIQNQNQNQNQNQNENENENENKTKTKNCIYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R537</accession>
    <name>A0A9Q0R537_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rabconnectin-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8526577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="4">
        <location>
            <begin position="799"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="2496"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1494"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1600"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2180"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1905"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1499"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1525"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1600"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2203"/>
            <end position="2215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2588" mass="303726" checksum="B2CC20F0A2DA907C" modified="2023-09-13" version="1">MKKTNKKNNNNNNNNNNNYYNNNNNIKIQQNSQLSPSQIISPIPKNQIQHTELSENTIFSYFSGSKIYTVNHHLHPIAQISLKDSFPIRLSWSHSKHLLAVARTSDIQIYHLFYQNGDYRFSLFATLKYKATQMFWSPLDRYFSIYSENLVILRINEENQFEKYFQIPIFSPIIDSQFSPDERLFFTVCQNDPFVKIWFNQSKSKTKLNFIYLRHPAKVLNAQWRTGYPLISTVPRKQNLLTSCADGLLRIWTEANFYEPFMFLHSCILESVPNTLVCWLNANISSPAKKEDIKFFPIPEKNPNFQINENENFSKEKNPIQTNPKLRIEYQKNNFISSFHQHEYYSPENHEVEYFIETPSERTRDLILGIDPEGTIIIWLIKGLSEQSRKIPKIKEFAKFYYAIKLINPQSQITHFYVSQKSFKSWPSFLAGDHKTLLPSHLKIFTQITHNNVSSDNDPLTEFTFWELEFGKEIKNRYKRSNNPSRNHKKTNPISFHKFHRFQISYSQDTIHIKDHIQEKENQNQNIKENQNIKENQKENIKENQNIKENQKENIKENQNQNQNIKENQNIKENTDTIHHTLQILNSPITLRSKIIGHPSEIIRIISHSNLPIIGSLDIKGNCFIWVYSESSFQTHSKYLRILGCLNMIPNDKTVSPNNANGLHCFYVDIHLENTAHSPFKYLGEVLNAHEYSTKNDILNVQIFISTQKNLFLILCFASFDRKNLVLKKIPFYQKKNKFKITIDPNSNNKIEIGIESNQEIASIASTEDICLSCIPDSLFNLLVADCSGIIHFFSITLTNEDVNENSFGFNCKKILKFQTFQKKISNIKTLNIDKFATFSASDSCICIWALKSSFSDFYLEQKIKITKPIQQMDAQFEWFDLHNNTNILTVCDGAKIVIYGPKPILHRTNLQKLTPQNEKEENQETSQQKNNYWEPLAEFANKDSQKTPFRTFQWSTTGLLLASCKDTIYVVNSIKKTKEQINDDYSDSGKETILELIHHQTKLLPYYHSQNLISDLKAGNFQRLDALIKHFFQFLQQKIENNQNMIPDIEEMFNFHKNSNETKQNYEDIFELKIENENQNENENQNENQNQPDKKEILEKIKYWITQVDLFPSHEYPKEEVIKLISLIELFFMKDNLKGALDDLAFHFFLQFKYNQILKENEQQFQMKEVEEQDDQQETIGNIESQQDSSIEHYYFSSSDIAWAFLSESQEQLIESCLTSPELFQWKNVRTLGCGYWIKSPQNLQSLAEKIAISEFKKTGDPEDCALFYLAMRKVSILSGIYKTTKDFKLSKFLQNNFQEERWKSATLKNIYKLLGFRKFKIAASFFLLIGRVEDSISIIIKNIQDIQLAVFVARLYLSDQDEAFQKLVFEKFLPLATNQQDVFIQFIFNFWVKKYQESINCLLGISIQNTHNLKDIEKENTDFRSINQPGDSSIIQFIQIIKQNEFMRNIQIPKEFFINYYKNLFQLHAKQGSSFLAFESLKRLDELLNGDSKKDDENTDFEKDDENTDSKKDDENTDEIFENDNSNFENDNSNFTNDNSNFENDNSNFTNENSEDELDGFDYGYGVGFGAVNRSNFMYGIDLDKIEENQIENQIENQNKNQNKNENENQNENQIENENENENENEIQIQNQNRNQIENQIKKGFLTKDLSRDVIKHFQIEFSLELLSEFLPQTTLEFSSLVLPLQSNPNKTQKNSHLFDDKPFQQFYRNLHFISSYFKIPKKILKNRLIKFCHLRNVDYPGYLFSKKKERKVYYIEILSDQISNIIEDNDIDLIHKLPKKKIFAFAQSLLILYRLRKSAQKTKDPSLEKTIAKATFTLYFGIFILGFMERKYDIIRDFLAKEPNEKHMFREVIKKLEAFIQEYIRNHFHPDNFAGMERAKTEDDLYDLELKQRLGLIDKQEINNEQFELENINTNIKLEQKKQQKQDEMRGKQSKVFCSSLTNISNVAFHLSKLTVLHFFKTQLKIQFVKCFGTEMIETSQMENPIESEQQILISMEHLNSEVRNHLVQFYQQNIDTIHSFALFIEEILHFNFQDEKHNRLWNFMRTKYKHIILEVIQNSICRSRFHHFGRESYKSHLTKKHSSEPPIEQTGPRVLVNSMGLFRSFCINNLDKNQFAIASTKGLLDISIGDSENERFFQLYHEYLEHESLTNPSSFHFSQCDSSRIPNLHSQLDLRPKHQSQYQHKNKEQQKQNDLVSPTKKKIKKKFRNKKNQPKIAHNLENFENLEQKTVLDAHFFNEKLSCLDRPMRYKLLIDLPNLKIPEKLISGPVYKFTKSRFLVDDRSQYLTQKKRKIYSLVSRAKPWNSANFTLESHHSSWVESHPKSPFYISSGLNGRLFFFEFQKKMPLYEIQKQTNKKILKVNFTPDGRQFGVSDVSGFVRLWNCDHKQNEPFQPFYSLECHLKRANDFLFINSGSVIATVGKTDSNTENISLWDTLMPPMNNRIAKFDVLNDGSASSLAFSKKYNLLICGGKKGSLHVFDLRKSQLLFSSKRNHKTTIKTIAINHDESVVFTGATDGSINAYDLPSFKLLEQFKSEHSKRLRFRDKVSTKTVAAYGVTRIISSGDEIISSGADGKIIARHFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R562</accession>
    <name>A0A9Q0R562_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exported serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R562"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="190" mass="22783" checksum="62B3E73F0308FEAF" modified="2023-09-13" version="1">MQANQIENNLENEIENNLENKIENNLQNNLQNKIENKIENKIENKIENEIENNLQNNLENNLKNKIENKIENNLENKIENNLQNNLENKIENQIENQIENNLQNKLENEIENNLQNNLQNNLQNNLQNNLENKIENKIENNLQNNLKNNLQNNLQNNLQNQIENQIENNLQKQFTKQFTKQNRKQNRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5D5</accession>
    <name>A0A9Q0R5D5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copine-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5D5"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="254"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="474" mass="55224" checksum="4B606E4195DA0C7C" modified="2023-09-13" version="1">MENLSDFKLEIFLRIKNLKIQKKETIITIKNNKSEEKECENISNQNIKWEHRFECEYSFGQIDIYEVRKYFIEDERRKAFGKLQFSLAEIIYSNGMKLTKPLLNENNEDLGESIEIIAREIQNINLSLTLNIFGRKLDPKGSYLIFKKPNQKEIFKTETQTQKSPKWKPVIISTNQLCDNNLSKLILVECYKFDSTFIGNFQFTMENLISQNQVTLPLKIANSQKKTKSEIVIQISEKNQEKSFLDFLQKTMFHLIIGIDFTISNGRANMESSLHHLDKSQPNQYQQIISQIGNVFEYLNKSKKKLQIPVFGFGAKFISQNGKEITPDFFPLNNNSDNPEIKGIDNVLSQYENSVETLYFYGPSNFIPIITSTKQITKHKFSSNDYYVLLIITDGDVIRISEFQKEIESLNNYSLSIVVFGIGDLEFPELEMIDQQDLNGFTFIPFSKIEKNTNFAKKVLRKIPKHCIQQFKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5G8</accession>
    <name>A0A9Q0R5G8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pe repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5G8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="265" mass="31741" checksum="D0257C8ED8565AE9" modified="2023-09-13" version="1">MNFDLFDDLFDLENPTHFEVPEFFFENSLKQDLDLNQNQNQNQNQNQNQFLNQFFNLNESSSPNINSNQKPNLNLNPSPNPSPNLNSNQNEKQKQKQKENLQFNLLENQNIKINELLDFSSNSNFEFDFDSDSDLNLDSFSFSFEKREIEDPFEKIQKEESINLKPNLFYLKDDLKMDFGNTLNQSRRSGYLSGILIEEKNEMKKIIFEKDFEFDYDSNFRKGIDKSKQKQQEKQELKLKQKEKQEIKQKQKQKQKEKQEQKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5L8</accession>
    <name>A0A9Q0R5L8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000131">
        <property type="protein sequence ID" value="KAJ5067271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5L8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF4">
        <property type="entry name" value="PHR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="479"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="607" mass="70869" checksum="B249EB31B72EF452" modified="2023-09-13" version="1">MNDCLFFGFNQNPILFKNEPEEITKPIQFKFENENENENEKQIKQISSSYFSTIFLFKNGKAIEYLNDSYQNPEKIQIEENIQKVTVGFSNEAILTIEGNVFAKGYNMNPNNPNKFINISSLIEDTNDRIIEDIVSGSDSIYLLTSNQNAYGIGLNEYGQFGVKKPKETKKPILMMKNVSKIFSGNTSSSVFLLNSNQELFGCGDNRYGKLGLGESIIEEEIKKLTKIQNIPKGKIIDIQFSNYHSIMLIENEDENPNPKRKLYSCGYSQFNGIDKNTYKFTEIKSSLFENDDNILDFSCGYDNTLILTSNSKLIGFGRNNYGELGTGDMKIQSIPIQIELPKLRFNENIFNYHLSCGSFNSFLYYSPSSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINLNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNESFQILEYWIYSNQIKDEIQITNEIINEIKTGIDYFQLNQTNPNLFDLLINKFNNQNHNNKEEKKEKKEKKEKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5T8</accession>
    <name>A0A9Q0R5T8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5T8"/>
    <dbReference type="OrthoDB" id="21085at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF104">
        <property type="entry name" value="PROTEIN SPRINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="586"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="731" mass="86539" checksum="29DAAB7451C3F5ED" modified="2023-09-13" version="1">MEFVFFEENTKKKFKTKKEKKTTEEIIQNFLLNTKEITYEVYQKSMFGFKKSIKLKLSAQGLIKLQNNKDEKIICLKQYNEVTKISVIDTFILQIIFRKKEVEKFYADDAILIAQEISSRCSVKFYLFHKWNKYIVKNLNDLVTMKNHKEPHPILKRVPSNLSRLIDKNHQSSDSQQNSDFNDDLQSIDDKKFDDDSDRSSDNFQKNFSTDDDSDKKEKNRNQNQNLNENQNQNLNENQNENLNENQNLNENLNQNQNENENQNLNENLNQNQNENLNQNLNQNQNLNQNLNQNLNQNQNENLNQIKNKNQNQNQNQIKNKKNKKIKSNSRNPSQKIAKDIIENEKIEYNFDQTPTKSIENKTIENKTIENKTIENKSIENKSMENKSIENKSIENKSMENKSIENKIKNESKNNSKNNSPRIENKNSAQKRKQTQEAIIDIEKLEKLLPCTMKIAEINEIPEYLIQLEMACIKILFIQNKYRFDKFILRACTFLEENIKEIKSKHGKPNIKVMESIRKFLDNIRKQIIKKNPELMKFLLEDISLGYHTSSEAKEILYYLLEKCLERIILLPLVDLIFEFFQLLCEKEDKLLKQNIQVLLDKEIEFYQLPEKLSRLCWNTPISTFMQFQLCKVPFEFLNNLINTADRIFFTTNIQNENRLENVGKVTISGDDFLSIFIFVIVHSKTQNLESYSRMLVSLCDPREFPSELGYYLATFCSAVEFIKKYEDQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6B0</accession>
    <name>A0A9Q0R6B0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="4">
        <location>
            <begin position="1407"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1324"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1557" mass="183634" checksum="BB90440B864A1381" modified="2023-09-13" version="1">MQFSKKEINQLTFPFLSILKNKNQIEQILKDYFTEYSQNKTNPLFHLKTLYTILNHYLLIIPEQTLNLPQIYLENLFLPKFQPNSLVLNQFFEEEEQIIIEIGAKIAIQNEKSLEIILKSSIQILNNIKENSNDNQEAILLQIKGASHLINTIWDLIEKQEQKNQNINNNLKITFSQLKTSIFKAAFNFVDFIDIKAQKIVLYLIISHFIHDPNFNEIITQKIDNLLQMEENTPFQEISINLLLIAFDIYFVDQFPERETQFFKLNQDINLNNSDNFLRKQSFKILQKLVFSKFSNSKIQNYKSWTQEQWKIYFYLFENIETSSPYLLEEHWNRISLLFNHRYNEYKVNTDNSFQNSFETIKLILILFGRGFKTPRIKHSTIHIFLTEFQTDLNSKEVDDFIINQVVFNLSDKIVLKKKKMEIKPQILQFFLSFFEKNIAKRTESEQNLFILKFVEQIVDHVSSPKMLDVYFDFFNSIKKMSIFEPIHVIKFSQLTSLLSNFPSHLRDPICLKYLKSFLQLVCLETLDFNSFSIFISRLNDVTNQFSKGKEGSKIIQNWFQKNLLQINQENKMEITQKSGFVDNFLNENNQYSWLIYTISQQIYQFFSFEYPLQDQKPKIHKISQMIHFIDDNHDPHFINSLLSQIQQILFNPKQNEQNQNFNANILKAFHLLGLIISSFDTNKALNFFLFENLSKIFELIKEYFNEIFESNNQQESIMKCEILSSFIFQIKIYLAKNLSFNQENHQQLFSQFSQTLIEKIINSSKKNTVSSAEFVFVFHSLFQNSDNLASLLNFSGKDFFSEIFEILIETKFGDLLESNGPHFYNQIMKLKSEILIEMMDCYEKEISYAQTKRIVNEFAEILDTITEKESFYSLMRGFSKALSQQIDHLEDDPSEKMQTISVMTSILDFGMKKSEELKMLNIYPLFLFQPKYFLIPEMESFIKQYFKDAISKSQTRSGRLNSVSASFLNALIQVNNDEISLKYIDEIIQIILVPKLPEKKQRNGFKAMDKLASRKEKMDSNYNDKIRFLVETTNNEYSFACVSVFLLQRCKLVKSNTSSQIFINSICSRLFLAFDQIGPISKKKRVKMDDLKNRNKIRVLQLLNLVIEYTSPNMKKDSISQFWRIFKESNISIIRKLVDILGVSLFTLHSHDFITEQHFWDPFFQQINLEIREFGLSSVFIVFHVYQKIKKEKPKEFLDKLIAFLIVSLAAKNTKTRNLARFSIQELFKEIHFQSYGLEKLKERLDKTKYDDDFGRSTKSSNKKFYLENSVCELFDEGMKNLSVDFEKSYIYIPLEIFQQVSDIFFGKESEVSKQIEEESILYKHKDDQNQDKKENQNQNENENHFKKKNNEVIQDENSKNIFQQKISPWEQISNDKNIDLNSIGNEERKKNYESRKKNNLIVCGSLLSKIPNLGGLTRTCEIFNAKMLTVNNINIIKENHFQKISVGAEKWLPFLQVKIEEIPTFFKQKKEEGFVIIGFTESNDSKFLSDFEFPKKCVLLIGDENGIVPQNIIELLDICLEIPHFGFFPSLSPHIGSSIVIWEFISQLLNQNYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6Y7</accession>
    <name>A0A9Q0R6Y7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000119">
        <property type="protein sequence ID" value="KAJ5068189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6Y7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34008">
        <property type="entry name" value="REPETITIVE PROLINE-RICH CELL WALL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34008:SF2">
        <property type="entry name" value="REPETITIVE PROLINE-RICH CELL WALL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040512341" description="PSI domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25663" checksum="3AB6D904605B4D00" modified="2023-09-13" version="1">MITFFYFLLIIGSVFSTICTSYTKCTSCLDDFDCEWCETNKHCYDSVSDYDYCSDWKHLTSSCPGYMATIFGAVFGGLAGLIILIACCVYCSKKAQKRRLEEYRKSGNTIGLQPVTIQQPSYQQPSYQQPTYQEPTYQPTYQEPTYQEPSYQQPTYQPSYQQPTYQEQNYQQQNYQESNLQLGYQEPNYQGPDNNYQNPVGMNFPDFSTYNPQQNQYQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6Z5</accession>
    <name>A0A9Q0R6Z5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein psp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6Z5"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="481"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="576" mass="67501" checksum="702C93C45D63F702" modified="2023-09-13" version="1">MFKEINPNKNPSKILNDLKQIETKQTLKELNQEENKNYEKNISTSFPQRFSFNSVKNEISKSNEKSSFEDLMQKYRIQTSPDKGISLSTSLDNSLFKSNFFKEMEHNFSKSPNFHQINDLFKFEEEKIIENLEDGEDDNKIKTKTTENKNSFPKFNDFSFNNFSPFPNSISFKKETSEPNIQKTITNQNGNESFFGKFQTTNSNYFQTSLQTSRSLSSLPQFGNHFEQNMNNMAFSQSPSKPEFTFEQNYHHFDNYFNGFYSNSNTISNSISNSNSNSNSNSNSNSNSNSTFDYPNDSQIESSTNSLPIHDEYFKKSENSIWNLNDQNQFKKSNEKKKRKEKKIKDLTQTNEDLIFSTNDQEFPHKTENETENTNDNDINNENDNEFYSNNNNSNENESDTYSSTLLSQSQNFTQYVDAEFKAGRRARFLASAEFNFNANDAIIVEADRGVDLGFIVNVIPIENQSKNSNQNKQKNSDNFKQVIRKAYQQEVADLSRKEKDELRAFGICQRKIKERRIPMELIDSEFQFDRKKLTFYFTAETRIDFRDLVKELFKTYKTRIWMKQISKTNHRNSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R769</accession>
    <name>A0A9Q0R769_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R769"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="411"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="72311" checksum="43C19BFD03B5963C" modified="2023-09-13" version="1">MNENTNEQDLKQVKENLFQDYTHLYQDNTYQDFSIFVGNPENRFKFQVHKSILSVRTGFFKKYLKKNINQIYFEQFNRVAMKTILDYIYLGDISFLNEKYILELFEISICFEINLLTRILEKEIIENVNKDSFLELLIKNRFLKSQEIENKCWNFIRENFTEIKEYLMNLNEKEMGIFIEKKQENNDTFDLDFFDFLNRWTEKKLDQLPNQKEQRAFERKRFFRFFFSRFDKDSVSKEDFEKLQNFNTFPKTFLITIQKSIIELNEKKVDSLQKDNEMKIKEMQAEWQQEKEKKENEMKERESQINLKDEENQTLKKEIEQKENDNEELKKQIKEKMDVNENLKKEFNEKWEKEIGAKEKDAKEKEDENITLKNEIENKWQKQVVDLQKELENVKSSFGESNLKFWFHDSEIVKELEDMKKLQEWINDNDFLSKMKKGFSAKRDGFDSKDWHKTVDNKGKTLVIIKTKDNFIFGGFTQVGWTNDKSKWREKDKNAINGFIPDPNAFIFSLRNDKNDRKPGKYTIRKSQEQFAIYYRTAYGPNFGGGGDFWLYEKLQPGYSDFGLYYNLPDGIQDGTNESKSYLAGSFNSWQVEEVESYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7D6</accession>
    <name>A0A9Q0R7D6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cop9 signalosome complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7D6"/>
    <dbReference type="OMA" id="WMLAYNE"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="258"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="457" mass="54504" checksum="8F3E8391A56F6740" modified="2023-09-13" version="1">MIIENQMNEENNEEKKEEINSDFEFEYSEEYDYDSLTINFHNQYYLSKSLIEEDYNLAIKGFEKILEMETEKTEWGFKALKQIVKLYFEKGNYSLMLEKYYQQLLYIDIVTSNRFENCVNSIAFKFQHSQDLNLDFDLLENFYKSTLKTISKEENWRLSFSINLKLGDLYLQHKKFQLLKNLITKLHTLCESEDETQSKQTKLLEIYSLELQLYSENNDTKKFKTVYNKALLLKAQPPLYILGIMNECNGKMFMRENQWENAYHNFFEAFRAFDDCGSERKIQCLKYLVLAKMLSKSMNVDIFCAPETQAYENHPEISLLIEFFNEIEKNNIENVEKILDLNKNLILKDLFIKNYIDDLLTKIRTNSLLSIIKPYTKIKLEFLSKELKINENELIKLIIRLLLDGEIKGRIDQINECLELENQNENENQNENFYQNINNFAQNLDKIHNSILGKLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8C8</accession>
    <name>A0A9Q0R8C8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8C8"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="263"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="481"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="584" mass="67984" checksum="92F79E4F55D754FC" modified="2023-09-13" version="1">MNEIIFFGSNQNPKLIKNEPNIITKPIQFKFENENENENEKQIKQISSSYLSTIFLFKNGKAIEYLNENYSKQNPVKIQIEENIQKVTVGVHNQAILTKEGNVFAKRKNNNPNNSNEFINISSLIKDKNDRIIEDIVSGAYSIYLLTSNQNVYGIGSNYSGQLGFDSRTLPKTQKPILIMKNVSKIFSGNASEHIFLLNSNQELFVCGANRYGQLGLGISRKETKIQKLTKIQNISKGKIIDIQCGSIHSIILIENENENPKRKLYSCGYHQNNGLGKKYRENTYEFTEIKSSLFENDNIIDFSVGNAHTLILTSKSKLIVFGYNEYGQLGTGDINDQLIPIQIELPKLIFNENISNYHISCGYDNSFLYYSLSFSNLEEDLIKLFRRKEFCDISFKTKNGEIISAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKYFEIKEIINSNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSGLSNKSFQIFEYWIYSNQIKDEIQITQEIIKELERGIDYFQLNQTNPNLFDLLINKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8P4</accession>
    <name>A0A9Q0R8P4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ovarian carcinoma antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8P4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="165" mass="19832" checksum="B03A764A201B9877" modified="2023-09-13" version="1">MDQLIQNQKVQIKCEFRRQIFSFSINFPAKYEDLLQIINSTPGIRWNRHKFILKYLDDESDEISIDSTMELNEAIKVTQQLKLSVLRIFIKKRKKLPGIKIEPIYSDQKPILQKPIQKKKPHHKKYHKKGKKRRAFKKERYRHGMKNQNKNKNQNQKSKSKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8V1</accession>
    <name>A0A9Q0R8V1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurofibromin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8V1"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="612"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="779" mass="92521" checksum="313DD3CC258DA784" modified="2023-09-13" version="1">MDFLLKEDIKSILELTYEIGFKNYLNKELIKKEKNKAKLSIEIIKNWINEILKKSTQKKVANSLFEDFKKIDFLIEFLLQVFPDLDFKKIALISDLKEKLIYILKEIQNNSYDGFCCSVDDIFNMKKKQFIKFLASLFLWFQNNNPKKKEKKAKIPKFNDPDFDNYIEEKLQSFKKSINYIETENDLQQKMEFKTIIEEIKLEIMDSSQFTISITETHLFSKNQNQNQKENENENENENEKEIPIQKEQILNNNIQIQKELPKKEQNRDLKYKILTMKQKIQENKRKIDDYQKLQEYKHFQEKESQQKFILYPEKFNSLNQFIQTSEKVSQSLNPLKEDLQDFMNSITKIPSYSTSLFKLLDVKIDDVPVGNIQKIQFKTITSFSNCLRGAFAHFKINFSEEEFKKLITKIKLFEQFDLDPYGVYSEIEDVFPKEYENIIQFRKFSIFILSICDLFVFTVYFKQLFTEKIVEILQENKNILQGSDVDDITRMIYGNIDNFIYFLSDLSKLKDIVQNIMEFLEIQDHINKSEKVIEELFRQSLSKTLFAIFKRLFEENQQEKIKNEVEKNKKKPTKIFKKDFAAGNQTLQKYLTEESIRLLSILTDANFCGDDIESISLSLFNLFDYLGLSIPLLKFTISQTITRISSVQNLFAYSDVSSRILSEFSFIYGAQYLHLTLKPIISEMIEFNQTIKTILDSEKDIPPQFRIINNYISTEIEKKFSGKGLISIGRFIFHRFLCPTLVSPQNYSIIKFPLNERYFKRFSFNFISNYSIIKKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R973</accession>
    <name>A0A9Q0R973_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R973"/>
    <dbReference type="OrthoDB" id="10251692at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="178" mass="20449" checksum="E82B0811CAC57B6E" modified="2023-09-13" version="1">MGIFSRNKSKKKQTNKKEKKGNKIEKEKEKEKEKGKEKEKGKQKEKENKIENSKKELIFFESICMGNREKVQRMIQKKPSLIYSITPEGYTSLMKAIIFEDIAMIQLLITSGVDPKTKTKGNSALIFACKIGNNEIINILLQLDRSIYETNQGESAFSICEKKGNPTISEFLSQQMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9D9</accession>
    <name>A0A9Q0R9D9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9D9"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="475"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="580" mass="67813" checksum="F2F80BF0738E7960" modified="2023-09-13" version="1">MNDCLFFGRNQFPILFKNEPIKITKPIQFKFENENKNEKQIKQISSGYFGTIFLFENGKSIEYLNKKYSKQNPEKIQIENIQKVTVSFRNEAILTIEGNVFAKGYDINPKNPKEFINISSLIEDKNDRTIQDIVSGSSSIYLLTSNQNAYGFGSNDYGQLGYDYETLKWAEKPILIMKNVSKIFSGNSSFHVFLLNSNQELFVCGDNGYGQLGLGESRKEEKQIDKLTKIQNIPKGKIIDIKCGNYHSIIKLYSCGYSEYNGFGKNENTYEFTEIKSSLFENENDNIVDFSVGNFHNLILTSNNKMIVFGNNYYGQLGTEDPGNQSIPIQIELPELRFNENISNYHIFCGSYTSFFYYLPPPFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNENEIEKLQEIISNKSIKESNQIFEMIYSNNSNINPVLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSDKSFQIFEYWIYSNQIKEDIQITQEIIEEIQIGIDYFQLNQTNPNLFDLLIKKFKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9M3</accession>
    <name>A0A9Q0R9M3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monothiol glutaredoxin-s15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9M3"/>
    <dbReference type="OMA" id="CAFSKRM"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="159" mass="17688" checksum="2B150C94264B7BFB" modified="2023-09-13" version="1">MLPQFISITNSKFQLPKQTFQLFKQFSSIPISGKSHPDFLPKIKSPDSPEAKKILARINKIIKQNPVVLFLKGTQKTPGHGYNRAFVQVLNLEKAKFLGIDVSEDSEALDGVRAITKIDEIPQLFIGGKFVGVGKDVLDKYRTGDLEDLLIESGAEFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9T8</accession>
    <name>A0A9Q0R9T8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9T8"/>
    <dbReference type="OMA" id="PVNFVWQ"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="779" mass="87289" checksum="93FA7C75D7A3B0A3" modified="2023-09-13" version="1">MNKNIIISNKNDPAPGPGVIQIYYYSSWGANTHIHYSANNGQWTPVPGVLMNISTNSTWPPPNFYVRAFYANTMQFVFTDGNGNWDHYKTGGNYYISMPGIYVVQNHDIQVIHTYPDACPGNPPCSNHGTCVNGTCDCQDGYYTANCSLYCNPDDHILCEDGTRCVVGHTCPPLPGCEIFTDGKCSGDEINMPDSFANRRWQTPGQNDPDYQSSFQYYNVLVGYADVKYSSDRKSATVNLIGIHKNSVTLTYEFDGQTQSSSQKSFDSSFNKPLTLAIYGADGSKLKLDPVDFMWNTHTPIVHESGDYRNGQKGSIIDLFGWPDEDIAQECESIGKMGYLGVKLFPHQEQLMSDEPFNDQLNPWYFYYQPVSYRLQGRHGTRDVLRQTIATCRSNKVRVYADAVTNHMVGSGNDMQYHRNSPSQGNCVYWPPKSSSASDVSPFYTQGFCYSYNNNTNLPPSQEFPAVPYGPLDFHCERPLNSWTSPLDLNAGWLTGLVDINTERENVQDRIAAYLTDLIGIGFTGLRIDAAKHIKPDDLVAIFTKLRTNLGGTFPDDFITWWEILLGGEADMLMCNENSGYNYGQYLVNKLQNAGFSLDDIKKIKIWNSGYPKEPDVNCQTDSLGKWRQVIQNDDHDQQEGGSSSRDMGDQGSVLVIDMDIPKHRYFEVKLFQDPNGVSDNSNECPIRNVLSSYYFTTAQNNVHAIPDGLSDCSLCKVNCDTCNTVTYTKAYQGDKCGYDGPVYTRVHRDKSIIMAMRAWMGLSTDVSNADIGIPDNCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAB7</accession>
    <name>A0A9Q0RAB7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAB7"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="487" mass="57539" checksum="6EFA8930155BB7A6" modified="2023-09-13" version="1">MNQNQITRIEKELNTEAINSNNFYHSNISNIYLIPITNNELESLKKSKFLSPPLKLKKSPKKENLIIDILPIEILLLIMEYLVPGEIILLSMVCKFLNDLSKDKVLWMKLAIRFEKFFIWEKIITTPPDLRSNHQIAGKLKDYKKFFSKKSNHDISHLDPNFDPSLYEDLYEINKRISNTNQYIFKSVKRQRVFYLNQINNHQKHLLAKGKEIWKMLKEQKKKAFTNTYYSPSYEYRELWDSVFMFLSCFVPFFFLFSLILIHLRLDWGYPINIFWISSPLIFLGILFIINFSFLWRYYPSDWQVFFNFIFVLITLMFTITLITLKLNGKISTKFSIIFIPFYIMFMILIYEGINPLLLNPRSSTETMVSFFGVCILLFFFILLGFTLDGLIRNYALTFLFFGIGCEFLLYALSKSGAPFIVPFLLSVATFLFVAGSSLYGYGWVKSFLVCFSPIFLVDLSFCFVSFWFVIDNLRKLIESISSIYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB15</accession>
    <name>A0A9Q0RB15_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB15"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="372" mass="42479" checksum="C1581132E95054C3" modified="2023-09-13" version="1">MNEILFFGQNEKPILFKNEPNEITKPIQFKFENENEKQIKQISTGYFGIIFLFKNGKAIEYLYDEDSNQNPQKIQIENIQKVTVGYLNEAILTKEGNVFAKGDDISSKNPNEFINISSLIEDTNDRIIEDVISGAYSVYLLTSNHNVYGIGSNLCGQLGFDSEILKETEKPILMMKNVSKIFPGNSSYHVFLLNSNQELFGCGANRFTQVGLGESIKEDWKIQKLTKIQNIPKGKIIDIKCGFYHSIMLIENEDENQNPKRKLYSCGYNKDNGLGKDDTYEFTEIKSSLFENDDILEIFVGQEHTLILTSKSKLIGFGDNDYGQLGTGDTERQLIPIQIELPKLRFNEDISNYHVSCGFNKSFLYYSNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBK1</accession>
    <name>A0A9Q0RBK1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBK1"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="112" mass="13277" checksum="0A73D067153EF7E2" modified="2023-09-13" version="1">MIHFKRFSFGESESDQQIPKKISTKIDFPPILDLSDRVINKNVDSLVYELFAISNHHGQYGSGHYTAYAKNKILEKWHFFDDKQVYEIDQQEIQSVDDAYLLFYQKVQKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBR7</accession>
    <name>A0A9Q0RBR7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G-protein coupled receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBR7"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="289" mass="32989" checksum="09A97BA261402E90" modified="2023-09-13" version="1">MIHNNLSIPTIIGSSLGMIGGLMFMIVYGLIKEIRDSGRKFIFALSVCDFLLGFSAILPGPSVNGLCQFQSFFLSFSYAGSFCFIFLLALVYFLKIFYGKNVDESRKFFIIAIIVIVVFCLISSTLFVTLGKVGSGNTHWCWIEKHRAELVVYSIIWVCLFGTVLLYSILFFKIRKEQKYSKSFQYKIFALGWIYVCTELFPSIKRARQIANPDVENNLFLDVMQSLTAPMLGIWDAVFFVFADKNVRTFIKVKCGKPKKSLNLIKNQNILMQEHLINDDPNDDLNDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCP3</accession>
    <name>A0A9Q0RCP3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCP3"/>
    <dbReference type="OMA" id="FQMNADI"/>
    <dbReference type="OrthoDB" id="17400at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF15">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="282" mass="33180" checksum="A05764536E5220A2" modified="2023-09-13" version="1">MIIVIEGNICAGKTTFATKLKLAIKENIIIFKEPVANNPYLEKYYGNPKEYAYVMQLWLLRQRFLTYLQAMSLHLENPDLIIILDRSIFSDYVFAKQNLVDGNLDQSQFEEYMKLRNKFLSLITQPDLIIYLDVSPEICFDRINNVRCIACESSIKLEYLQGLNKCYKELVQESRDHQISVILLNWEHFDRCDDILSGVAKLTIPEFLEKSKINSNEFLVDDQTRTIYSWLRIVSSFGNQSESFNLFKSSKVIFKFESFETNLEDLIEFMGMKTKKEFFNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD53</accession>
    <name>A0A9Q0RD53_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase faf-x-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NACTENI"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056850">
        <property type="entry name" value="ARM_UBP34_24_USP9X_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF910">
        <property type="entry name" value="UBIQUITINYL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25010">
        <property type="entry name" value="ARM_UBP24_USP9X-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="1434"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1696"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1703"/>
            <end position="1718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2927" mass="343025" checksum="A4720E9A9AB76886" modified="2023-09-13" version="1">MTTTEINPQIARYQKILKAFNLEIEPLEAIEEIEKEMSEMIKGNVETEQEAFFFKTYFYQLINTLWKRVNISIGFAPRINQFYQRCLDLIYSKIEKEYAGLGICLSRIFGQPQRGFFDEYQGDPNWKSTTLCHGDFVSFWESQDTTQFLQKPFDPIKFEDLKIDTDKMELEKDQEIEKDQEIEKDQEIEKDQEIKEDKFNFRFVKQSMKDVSSFFLENIEYFGRIRGFEKMIRFLLSEDHKLTQEVTYNYLRCIEKISNQYTQEFLKVLTPYLQAFLKKITLVDFQQLRKMGEANIKNVAKLIFKAVTSLDRKITNDFKADFYPDLAYRFMESSFLDFRVSGITTIKTIIIQLSDSKNYPRNYIHHKNWVDKEKFFKWLENKDILGLLFGPKMHHEITRRSDELINFLLANNKFTEEDFVKMWNEASGQHQINAQAIYKLLCDITIRNPEKLFQVLFSKMKQIKEWDFNTLTLLQNLAIGTIGEYIPKDSIKQQYIHPTVLMWNLYIGEKIDLDLRNQVFENLKTIFDSNACTENIKTMFVSSAILELQKKQNIASTLLILTEIIKTYPTQPSSSFFKSVSTQATVIKQCIDNKQLLIRVMEDIARFKEQIRILVQKHGYKSENLNDKIVADRRTYLENIEIRMNFLKFLADSLNDTIFTSENVEEFWKFFFEEALTEKERELFSNWIITLDSTTDILKEFMDKIDAVPIGKLTKTMFTLWKHLCTKINFENKVISGKTRIKVIKTEEKQILGMDRLWQLILECENEEIANLAIDYIVEYQILSKKLSNKLGQEYRKRFINKCIETIRKSKETNKVAVGRIALVMRKLVEAIEETIIPERIPFTRHMYSKMKPFDIEVIFQDTETTSYKLNVHQSQSVYSLRKEISETIKKKFSEFTITSHDEICEENNHKTLSQTTLYTNPQISVAVNQNQYSNYYYGTTGYMSQYNSPQQSLLDTSKIEGDLLPSFILLDFFDDLFSLLELGNKIAEDTWAIINWMPTSKQHEQTLLNVFEQADEQKGVVWNDILGTKSLHQLFYQLQIVGRLMDTSFIEEKEEQNQDKLKLKQWPTKFIENGGIKHLIQLLMEISLLEKKEEVEQKEISSFIPQTVSLLFKLLDEFVINSETMKFNAKDFFDKETEPQMMKFIIDLVYKLSQDAQENESQEEYLRVVNHGMRILVAGCLTPSEPNVWLEGIMAKTDLKDWIKQMLIYCAEEDMRKSVSTALLDIMKFYSQNPKIFDFFMNLLLSFLDEFEPNNQIQKNNRIQHRAIYFQLISEMLELKPQMLTSEPLRNLLERGIQLIKNQKVYDKGTPEHKEAEKDIESYIKLVHVLLVDTKTCDEMEQKFGLMDEIFYKCLFDVKESLEKQRGFMPKCSTEESRSAAFSLLRHLAEKSSQNSNRLLSLLTQLHGNVKPKKTKKIRYDYYSMGKSSAGYVGLSNLGATCYMNSLLQQLFMVPEFRYGILSVDFEKSKLEKGAFNDDGTPKDMTQEIEGDVFYQFQKIFAQLCESDQRAVNTRPFVSVFKHWDGTSLNPSVQMDSYEFFNMLFDYIENYLRGFNQPDLLKDIFGGKFAKQIITEETGEVSEREENFYAISLDTVNKKNVVESLNSYIQGERLVGDNQYFNETLGRKVDALTRACIKELPKNLILHLKRFDYDLETQRRSKINDRFEFPFTLNMEKYTREGIARAEMQQIKSEDLLSGETQVEDPVDDTDEMDTTEEQIKSKPKPKPKMKMVKTKSLYQAIEEAPNKVYDYELVGVSVHYGSAEYGHYYSFIKEREPINEGKDLRWIKFNDSTVTEFNPDELPEETFGGKEVRTYKNFYGSPYKQTFEKHYSAYLLFYQRADIVARSREAIAEKKKAFYNTMLFSKIWSVNADLFYEQNLYTPIYFQFLNSFFQNFSFIRDSMPLENAFETTKSFIQFLFQVVDFPNIKVDFVQSLQSFKDFFSSNITNAKWFVNELCQTNNTWLSQIYHNLENVEFVNEFNSVIISTIGMIYRDEEPQIDEFMSNIKGPLISCTSNSTFYDLQNTWSGQMSLEQTTQLDPSIPLFVQLVRSFLLLLDTSQSDFRNVSQFCQLLSDLIRNVPKSLNYLISIHLVTRIIHFYLGTKSPLYKFIMSGGYRGLEIEKYPGIVEAILSVFEIYFDQKPKQEITESTEKQSELEQANPNPMEFLPALDVKMFTESPFLKTLIEKGDNPIALGKIVNLLYADNIVKIQGVIDDLVSRIDKEQHTTLPKNFITLQQILSFHDSIYKRKLGYAMDNLLLILARNYRYEKATLESIKRFYDIIISNPDVLTWMAKNISRWFTDWIIYFNSEEIRIIAFNTFKLMLPSDNDTSDEATKTLTSLFEFLLSLSSTLVTQTYKGISPKQKPNYNSNEPYPPDFFKMIHYFQLLITCINTRKIPQFEDIFNKNFATFFKLYEHIEYFKLRCDQNKYQFYVFINKLAEMFPDCLSKFTEDSQVTNTILTSSIVLDALESFVVYNRKFTKEFMFFSYQCCKHSTKFTNTLSNLFQFEWALEWLCFDTDRYSETSEIISNIVIFMKNIPIISKVVLKISIKKPYRISQAPYKIINILDSIVSVENNEIFNFLNSTNSPSSNIFVPITDLLINSLNTQNPTEEAYSLATKCFNILDIFAQSTLKFESSFPPAFLQYWQNSQQLITQSVQFIHFCDPVHLASPLGTTVRDLILHLVQIDPKFPLNLLELENSILSQKSTSDSFISSALYPQFFSSIIHLNSSDSSSFPTLRNYFKSVTQFVFSLDHQLLVSLINSLIILIDKNSFKTNSISFLIQITEDYLTLLVQSSSSISLLTEKSFLHSFLNSLFSFLFANQKIDSQFSEFINNLIQILTSKINFFIQSQFDFQSVKLLLNLIIFIISFENVTNLFDSLSLLNFVNDSLSKISKEDFDKLNEEISKIKDFCSEMKQEKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDU7</accession>
    <name>A0A9Q0RDU7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homeobox protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDU7"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="266"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="268"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="332" mass="40066" checksum="DC559BCEBFA4B9AE" modified="2023-09-13" version="1">MDQFDFSVFIDGIELETLKEIANFEKKEQEQEKNQKQKENDFDFDFNFDLNFDLNFDCNCDFDCDFGMQNKKFNSQLDSDINFDFDNQIKNDDQIIFDDKVFQELKSKIQNHPLFSLLNQLKKTNKKQELKMIKKKISKIESNQKSKLSLIDFGLDSNLDFDLILSILTRKIFFETKKIVNFFDQLEKLISSKKTKFDRFCENLLIECRKEKEKEKEKQEDEEIDEEIDEEIDEEKFNQKIPKRKKRRATILFVNEIQKNREIEQIHLKQRRHNLPQKAVNFLKDYLKKNKKNPYPNQQEKIKLSKLTGIDVKQVNTWLINARRRIISKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE98</accession>
    <name>A0A9Q0RE98_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome subunit alpha type-7-b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE98"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="78" mass="9107" checksum="1A37B89635653F97" modified="2023-09-13" version="1">MENQNFIKRIQNYKEVDEEEAVKLAVMALVEVVESGKKNIDIGVLRNGKQIEFLERNKIADLVKEIEAEKKKKEEDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RED7</accession>
    <name>A0A9Q0RED7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein -related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RED7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040494133" evidence="2">
        <location>
            <begin position="20"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="3">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="418" mass="46218" checksum="BC68F04149B37EE6" modified="2023-09-13" version="1">MNSLLFFILTITLLSVLNAQITIQDCGAPTDPLQLLEFNYTPSNFINIDENFTISIIYSLTQTLNTGTVQATLWYTDFNGDPLIPTVDFNLCEIASQIKCPLASGNHTFKSGRQFPEFPLGQYKLRIVVVNENTVRQACKDIFFSVNNGTTPVSRCEFLSYYNADGSLPEIHYQNQPIFSRKVGDWLQVGTLGPYSTGNWANGTFSKFDASPDNLINAEMDYQNYIWGINCTLNKITNTSSNINFNYIGDFWVGNPSSDLISWDNYFLKGSINFVSSYSLTTQTLVDITGDIDVEPIVHVPPVWHVIIGFGDKNPGSISFSSQYNAWSVSAQKIVCQCPIDVCGVCGGDGSTCAPSTSASSNTGVIVTSIVVPIVVITGVILAIVFIRKRKQKKNLRDSIFSQYGTTDTWQNIDTQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REU9</accession>
    <name>A0A9Q0REU9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REU9"/>
    <dbReference type="OMA" id="MHINGAR"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="211"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="335"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="389" mass="44245" checksum="9EA3316E6DA42C9F" modified="2023-09-13" version="1">MESIHKSIKELGLDTKKISFVCYGDVIKLRHKSTGKRLHSHPINYNTGSKQQEITGYDGNDDNDWWVVHGPHKDGDRENCKKGKAIKAGDIIRLEHVKTGKNLHSHGNFNSPSTNQQEVTCYGDSGVGDGNDNWKLEFKETKKLKWKPDMAINLTHVNTGAKLHSHSGHQTKVSHQQEVTGYKGGDANDDWALDIIRMEDRISLLTSQLGKYKICYGDVIKLRHKNTAKRLHSHPINYNTGSKQQEVTCFDGSDDNDWWIIHGFHKDGERENYKKGKFVKVGDIIRFEHIKTGRNLHSHSGIKSPTTNQQEITCYGNFGIGDSNDNWKIKFKDSKKKLWKGKNTITLTHVNTGAKLHSHSNITIVSKQQEVTVYKERDSNDDWVLDALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG27</accession>
    <name>A0A9Q0RG27_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000023">
        <property type="protein sequence ID" value="KAJ5079631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG27"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="84" mass="9647" checksum="02E2187C282BFD7C" modified="2023-09-13" version="1">MYQVFPMQKKDHIAYFVVFRVNAPMSFNFTSPNAPAFGLSATLRRGGSVDDLGLYTKTTNVAFLIYFFSLLFLYCSILIRIINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG28</accession>
    <name>A0A9Q0RG28_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endonuclease 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG28"/>
    <dbReference type="OMA" id="LRYFIHI"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF10">
        <property type="entry name" value="STRAND-SPECIFIC NUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="293" mass="33370" checksum="A8712976447D9FE1" modified="2023-09-13" version="1">MKLTQVIVLGFLFCFVFSWWDNSHMIIIEIASRNLTTTQKNKILDILSTWEPDFPGDLYGAAVWADKIKSPPIKIDSMAGWHFADLVYNPDNIKVNYTLPPGNVIAECQQALDTLEDNSCTSVWAWAFQLRQLFHFVGDIHQPFHCIDLFSKQFPDGDRGGNEFKLKGDASYDSSLHFFWDAAGGEYVTNYPLTQSEINDLVANATEIMKKYPVSYFKGRFSPTDFDFNRWANESYSAAVKYGYTDIEPNTYPSSSYTSRCFEISQEQIAIAGYRLGACILKVINNAPDVNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG33</accession>
    <name>A0A9Q0RG33_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress response protein nst1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000048">
        <property type="protein sequence ID" value="KAJ5078714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG33"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37458">
        <property type="entry name" value="THISBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37458:SF1">
        <property type="entry name" value="THISBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="315" mass="37758" checksum="272B802E8F306EF9" modified="2023-09-13" version="1">MSIHEEEQQLLIIGNKFEANKENKINIPFLIQENINSKIKTNSYFKLIQKIPEMIYPKMNPQFQNENFLKNLYVTQNFINSINQKEILNFRLRFFTRILLIIETKTKSKIWIFLTQQEIEDIMEFILDLKMRNIKKDNNNNNNNNNNNNNNNNNNNNNNNNDNNNNNNNNNNNNNNNNNNNNNNNNNDNKNNNRNSFILMSLDGNILCRFGSEFKDITTNIIQKKHIPNHHQHFNLINEIRKTLFIFGLLKFHWGIFEIGRNKNKEIRNDIEQELNNFYQLQENFKDNFSQNLSPFKKKIHFNLDQISKNNSKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH59</accession>
    <name>A0A9Q0RH59_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH59"/>
    <dbReference type="OrthoDB" id="49113at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="702" mass="82591" checksum="91033AA90221366A" modified="2023-09-13" version="1">MKSQKKQIPQNTQVRIKNFGYQEVQFYDSLHSNWETYKGFENAQINVQFTKNEMEIECKSENGKNPLIFPIKSGTIHKLNGEKYSKKPSYVEWKDGNDKFRIKFDDYVRAKSFDNEIEDLKDEKEDNLIKFANIDSENNNINNNNNNNLIDSMKGKYFDNEQGIIAQARILGEKLKIVTNWLLPPSKQKKYIFTGDEIVEVANDHFNFQDGTSFTFEKNEDFKTSVQNSCSKKSEENELKNMTIEFLKQGCDYNGIELEKDFEMDSFHIYTEKDTGFIINKTRYYPPVGWIRLKMKNQGNKDVSKWSYGYHGTKYENIKSIVKNGLVIPGNKTQDGKIVEIRKGHIPNQNHIYSSQSYIYASHPIYALPVHFNYNNKSYFVRVMFQIRVDKVDVTQEHTIRWPDNAPIDLQVPNELLEWIIFSSDQIVPYGLLIKFDEEDPYDIFEKIKKERLENPNWSHRTTPKEIEKAIHLNKEASKEKKKKILWVDDEPENNKPIIEVARKVGLKITTVIDTEKAILEYQKNPEEWFLIISDMKRIEVRTEHPKEKKEYPTAGLSLTQSIRQINKDIPIWIYSQYTRTHPISYSICYQMGVSEVVNISRILTHFFPYDPIYENNDFLTFEGLKDFEDSSNVFLNIKKGQIFKVIVLFKGRSFVADIDNKTTGFIPNNLIKKSKPQKPKEEKIKNQNQNQTNNFFSFFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH78</accession>
    <name>A0A9Q0RH78_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH78"/>
    <dbReference type="OrthoDB" id="19132at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="295"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="482" mass="57407" checksum="99F2D096623D54FA" modified="2023-09-13" version="1">MENYLNLEKLSNDLKNLFQNQNQNENQNESYFDFEIICEQNQISFKTHKSILSSRSYYFKSLFNSKMKEYQENKLILKDVSSSILSSILNYFYSGKIEINLENAIEILIFSSKYLIDELIEICLNFIKNNLQFETIIDILKLSESMNLNQLLDSSYQFISENFEEFIKTPFFLELEENHLKSILSNDDIFMNEFKIFQSIIKWGKHKSNINQEKEEKEEKEQLQNQISNIIDKIRFIDFSKQELKDTLKEDLIPNQISEKLIQFQKLQNDTKQLNQFIEKENSFIFKTRFRFKSKIIQEKEHFNKLKEWINDEEFCSKMKKGFSAKKDGFDCKKWHSICDNKGKTLIIIQTKDNFIFGGFTQIGFTTDKSKWSENWRDSGHIRDSNAFIFSLRNDKNDRNPEKFPIQKKKEEFAIFYVSNDGPRFGEFDDIWIDADLLTGGTFFGNSYKLPKGIHYETEKANSYLAGSYDDWEIEELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH93</accession>
    <name>A0A9Q0RH93_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000017">
        <property type="protein sequence ID" value="KAJ5080007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH93"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="99" mass="11518" checksum="925CC3BCEFEF45B7" modified="2023-09-13" version="1">MKDLFDKSQFVIPKQHTRHFEYQGLTTLRVGNNGFEIENVIENVIENVIENVIENVIENVIENVIENVIENVIENVIENVIENVIENVIENVIENEMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHA3</accession>
    <name>A0A9Q0RHA3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_14186</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000015">
        <property type="protein sequence ID" value="KAJ5080037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHA3"/>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="16">
        <location>
            <begin position="650"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="15">
        <location>
            <begin position="815"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5080037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1011" mass="117562" checksum="4B396CB2FD44E3CE" modified="2023-09-13" version="1">MNKKSKLKKRNQSDSETENLESVIQMEQDENNNNNNNNNNNNNNNNNNNNSNNQVDLDRPLINSSQIETFSRTVIWGTTINVEDTINNFRKFIDEFRINGNENENPYYFDILSQVVETEQNSLNIDCQHIFQFNENLYKQTIKYPQEIITIFDLVIKDLSTEIRAVQGEDNETTFKNPIKVRLFRLLESDVKNLRDLDPNNIDQIVCVRGMITRTSQIIPDLKEAFFKCQECSFEEVVSIQKGRISEPLICSNCSQRFSMELIHNRCKFSDKQILKLQETPDAIPDGETPQTVNLMCYEDLVENVRPGDRIELTGIFRAIPIRTNPRKRSVKSIYRTYIDVIHFRKFDKNRVSDGRINLGDISTLVEMNQTEEQIKKLEKNLKKLGKSPNIYENLTRSLAPRTEKEFSRSGGGRFRSEINVLIIGDPGTSKCLTGDTLIQLSDGNLKTFQEIFHENSGIKLSKGIFASKNNLSIISFTNHYNQVKSFVPTVSRRKVSQLLKITLKNGISIKSTLEHPFFTSFNDKIYKIQAKDLFKGLKIISPKNIQNYQEISLQKNNNLINQKKARLIFYINFISKFGSFDDKVYYLIFDSENSIILNDITNILNTEFDQNDLEIKNLYQKLFVKFNRNSHLYKFIYQNLSDSFSLKKNESIPKIIKTSSNLIITSYLEVLLIQEGKFKNKSIIYSNKNKRFILELFMILLRFGIQTKIKKKKNFEFEFEDEIYKKQKYYQIKIKKNKLSKIHPKFLFNIEKILTKKEKIIIEDFKQEEIPIIKRNLKKQEIKKIFKLEKIKKIEMKEKETIWVYDLESSKGRVYTSGKGSSAVGLTAFITKDPDSRELVLESGALVLSDGGICCIDEFDKMSDYTRTVLHEAMEQQTVSVAKAGIIATLNSRTSVLASANPKDSRYNPRLTVVENIQLPPTLLSRFDLIYLIFDKPNEQQDRRLAHHILSLYSRKPETQSEEVIDKQTLTQYISICKTQLESLIRISEAHAKIRLSNHVEKLMLMKLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI15</accession>
    <name>A0A9Q0RI15_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho/rac/cdc gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI15"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="557"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="743" mass="84871" checksum="84E0D73BD1355114" modified="2023-09-13" version="1">MNPPKPIRNLPPKPFTKNLPPKPKTLPPKPALNRGRGISPPPKPTNPPPNKQNLQQENFQLKKPPTPPKPPTSPQSPSIQKYQSLPSYNIPPVRNDLKSPRQGAFPTNKTAFLAQKANLETKENFEKKEKFQTGNFLANKPKQKTPSPQQINLQEENGNIKEEDIKKGDIFNGELQGEEKSKLTRRKLPKTHYEKNEDSRQQPIPPPRPTPKKRGLPQVPNSVTNQKTEGTNYTKKLPPTPLERPLPNIPTKNKQETQSPNITSTVSLPAGPRKNIRRQLPQTPNSKTHLPDQSSQFRQPPNNPNISNIISTNQDDNTDENESEDDFLNSILLHEFAFSSRLFDVIKNNKTKHDSIKDIGEKEIAEMMQSIPSSEYGNIEKNPDPKNHHNAFENVENFENVDLGIEIKKKWFGKKKHRQSQMIPQQQEITPTPQISQAVPEPTEKKQGRWARFKKKTTKLKGFLTKKKNKDKKSQIEDPLPSHLQTKNISTSPQTNNSNISKTKTKTKSKSKTLSPNDAMSPSSIKKQMEMQSKILLEPRKKIINDNGIACFGIPIETLSEREQRDCAKIPDFLTQIFDYIEEKAKYTTGIYRVSGMHDSIAQYQKTIDQGKPITFSDFEQHEASGLLKLYFRMLPEPLFSNELNQIFSEKFSDDIFSDDPNVDKYDILNQITSSMKKLSLPNRLLINKLLSHLFEISSYSHYNSMTPYNLAICFSPTTQIPMPLLTFLIKNWNDNRLDCNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RJ67</accession>
    <name>A0A9Q0RJ67_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor tfiid subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_14040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RJ67"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5080519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="115" mass="13474" checksum="54EDB28A665F72D7" modified="2023-09-13" version="1">MSDLTRRANISNQPNSQGVSSRKKLKDIISQIDSQLTYDLRVEDFLYEVLDEFVEKITQQACDFALHRNSKDLEDQDIHLSVRQHFSKNLTTEQSTFQQREDGSELKRARTNQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L552</accession>
    <name>A0A9Q0L552_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_03381</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="LETWMEV"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="13">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="980"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1314"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1071"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1317"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5066048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1802" mass="212094" checksum="312D7E15EFFBE29F" modified="2023-09-13" version="1">MEQKFAKLLHSKEKIGSFLKESKKNIEKFMEYLITKNKTTNFIEWMKWILSEGNEPNEYIKTLKENNKKNSGRCGTFWRNDQVCYKCRTCGLHPTSAICPECFFNGNHEGHDYYCVKGSLGMCDCGDDQSWKPTGFCKNHQGPPENPENVLHQDLRERVSIIAKYTIKYIMFLFTERFQVLAKMEVLKSSNRKKKSKQNSLDDEQIKIKVDQNQDQIIALINWFNEFLSFGDGFKRLAIFELIKQKVSGFLLGLPNQITSLEFFMRLSNLESESIFKSLIQFWYNGITDLVFKKEFLKIYLKIYKEMITNLIEIDDETHNDITELSVQIFTVPKFSHEFCNDFNLFEILFETASEIINKTLIPIKPNAKSKQKNRKLEPKIPLNFKKIDLKNKIFLNIGIWKIVSDIRYSLRENYSAQFIALERQSLYKKFLEIFKNFQGMNMIEREKNKPSEYEDESWKKSGIFSADDENNNENNIENENNIENENNIENENNIENENNIENENNIENENIDELQQIQIHKISDSFKSKLVQLIRITTSMIIDWTIENNFMYRDLSPMFFRISQPRNLEQQFVQYQLYTYDISSLPISIHYPLQRILSSLIISVVKHWNLQLQDLFKEVLVYSEPYFDSFIVLVIHVIRLRAIFSQIHNNYWTKNGASLKVLANLQNGSTFSSYFVDKDLLLLQIAAVVMDPQKLILSIMNAFQLLNFWVVDPNKLDNSKEIEFQKLMAQDFLKLLLLILVERANIGFLSKEELIRRDVVQFLCVRNQTHSQLEKCVQSEIMDEEIFEKVLKDVAIFNEEQHKFRLKEENWDQFEGQYYPYFSYELIQVAEENYINNLKSRNSKTNLKIPEILPGPKYKPLHSSFANLPKFLNNHLLHQIYFTVLFNSAKKNQLSSDELLNYTLNLMKFSLTISDINENLNENIIQNENNQNIIQNQNQNQNQNQNIIQNQNQNQNQNQNQNQNQNINIIQNQNENNQNINQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQNQNENPKKNIKKNSNTFNTALDSIHFPTFNDLPINSAFLVSTPFGKFRIVSLLIHLYKQNLNQDNRMLVEQILKLLQNKNQKCKEIIKQKIKNFNLIIQQKEEEEKKRKMEERKQKVLQQFNLKMQRFTQKNKKELDKIEELEEKKEENDLQKNQTWSLADSSISELKYDDQIESLCCCLCHEKDSKSSLVSKPLGIVGFIQSSNVCPIAELKYFKDQKIPIESENFRKNIYAISCGHLMHIECYQRYMTSLVARRTKGIPYEGIYVIDLGKNQFLCPLDRQIANTVIPIIPNSMIFENENNKNENNNENNNENNNNNDKKIIQDYTNNSYENSINFFNQFLKKLDQKKEKRTNLSSKMKNSIDGFLGNLHYFISKKKLKSTYQSESGLRLISKLLANTLSIFEIATRNEDSQPLDSIQIFQLQSYYRMGIILGQLPAKEESVVEKFRFQIFNFLTNNIVDPKNDNCILKVDLMFYFIIMHLMFVSRASHSDCFFNLCQIVVYPVLYQIIAYSCVFSEKIQKKYCILGKFARNQKTGSIYIENEEDVAENIKSLCVPILRKLYIYLNYCVVENRGCEKLPPKNFETLCNLLKINIPVEEILSSTSETSSLWKYFGIEDGKFDESKKTQYVIITPPIPFRFYSVPQEFIKIWLEYEKKFDEHGNKNPAHIALSLITGDIVHLKPNVNSVNEHQFVAIHSKRIGGNGIYLCIRGDLASAVLTYQKDFGMICLKDIYKDKWNETDIGIQRGKDLFLNEKNLVELRNAFLYQKLVIQAMEFRRKHPEVGRFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5I8</accession>
    <name>A0A9Q0L5I8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase rbbp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="ANYQRPE"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
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        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="290"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="390"/>
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            <begin position="94"/>
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        <location>
            <begin position="751"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    <evidence type="ECO:0000256" key="6">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
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    </evidence>
    <sequence length="790" mass="93986" checksum="2B12B76C1542E7FC" modified="2023-09-13" version="1">MSYIEYKLVSENRADRIILDERTSITLGELKRAILAKFGGGSSQNTDIQISNAQSGQEYLDDQESIPRNSSVWVKRIPLKINYFPDKTHKVIKTDGKEEKKETENEKTKETTNGEESKTNEKKQQQQQQRNDIKSNRNRLPKGIPADRLKPIDGPSESGGTTYKLRNGTYAVLQPDENTFNNNIKTYKNINLEKIPEEFTCQLCHKILRQAVTVKCCASKFCDDCIRTHLKFLLKILLQIKRQERKFKFFYKKRKIKIKTKMKIKTKIENKNQNQNQNQNQNLNKNLNQNQNQNQNQNQIENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNPNPNQNQNQNQNQIENQNQNQNQNQNQIKNQNQNQNQNQNQNQNPNQNQIENQNQNQNQNQKFIPPKQRPWHVVPSSISDKQKRNPRATPTPPTISTTVPTTTQPPYFPGIFPYNAPSYPFPYGINYNYVQPFYNPIPSNPQEPKIPDSKDQTKETIEAKTNDEKIGNQLQEEYRYEDPYYPNNLNQRRYYHSSYRFDYNPRKFPRESHSKYDQKSEYNSHQYKSHNYSSRYQDYHHRNSHSKESHKSHSRSHSHSRSHSHHNSNSKNEENNMDIQKEKQENQSKLNDQNSNSNSHKSHDSFSKNKDDSKHKDTKEKMDHNHHYHHHHHHKNDSNQNDSNHSKENPHKKSNEEYFKKYHHSKENPKEKENREEKKKSNEDYFKSYHHSHHHSHHHSNSTANETQKDKESQLERKNSSHSPNDSNFHSKNRKQKETKEQEKEFEILFPEIVKNQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6A4</accession>
    <name>A0A9Q0L6A4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5067041.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="113" mass="13545" checksum="DF5DCB033ED1B4D4" modified="2023-09-13" version="1">MEEKKEEQKLEIKKEEQKLEIKKEEQKLEIKKEEQKLGTKKGVLAINKQAKNEQRELAKFYLTPRIYQYQNITSLDKVTIGEIADILEEYKILYDENQKLYELLNTIKNPTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6J4</accession>
    <name>A0A9Q0L6J4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Er membrane protein complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAJ5066730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="23531" checksum="F54237EFF284899E" modified="2023-09-13" version="1">MISITPDAYCHIILHSRKHFMEPVTGVLIQNENKDQDINNTVVNEIIPLFHNFSSYTLSINYDIAFAIINVYCEKNGKKIIGLYHGNENQINNAIPSSIESVVNSINSVNKKGILLLLNNKKLENFEEKSVFDVYESVQLKLIKVSSDNLIAEENSNESQFIVENFETTTKKLKELLENNRFEEIFDFEDHLLNPEKNFLGGKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L793</accession>
    <name>A0A9Q0L793_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L793"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="442" mass="51911" checksum="C671739113C3F8BB" modified="2023-09-13" version="1">MQDVLDPDIFESCSPKEKKAIQKIQESLPLIDFKIIYEIYKSLGSKHPIDLVYRVYLESNNSQEKTLRLLLENKTSWQPIRNHRKKSKTKNPKPNHSKTKTTNSQLEKPQTNQDVQEEQPIKDIIDPKNEESFKNRKDSKPQRQRSKHANHQLTKEDIKRKTERYRRIERELGISLLEKNPPKKSNHPKKVSKDPKKTSTKKSPAKKNGKNLSESKSKSKSKSKSKSKSKPQNQNQNQNQIENQIENQNQNQNQNQNQIENQNQNQIENQNQNQIENQNQNQIGNQIENQIENQIENQIENQIENQIENQIENQNQNQIENQNQNQNQNQNQNQNENQLQQNLNIEEKKPILDSSQINNNNDDNNNSKNQNLQVNQQVSKLQIKGKESIKKQEKKLTIEPNQKNNSNYVIFADHLNPPKNINILFGKFHKSLEIQKPKNQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8T1</accession>
    <name>A0A9Q0L8T1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium-independent phospholipase a2-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8T1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="366"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="370"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="402"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="568"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="944" mass="109712" checksum="2C50822A95E7B3AD" modified="2023-09-13" version="1">MKQENNNNNKEEIKNNSFLKLTEKLKEDLQFKSLMQKIFDKQKENQKENQTNENQNQNQNQNFTIKNNERKIVGEWQNKELNKLKLKFTKQSKNFIVKLKQKEESKTFLEKDLANKNKKNEDDKLEAKITLKDLEDLFGKDCEKQEKEILESKDNERLVDLIVLDILGKDKKEKKKILESQTLDRLIPPIVNSLTGNPQPFMMKNPNLLLLEAKQLLGDKRYQQSYRILDNLFKDEDIDVFTKKIIEETLKNAKEEIENEEKVKQKEEEKNEMKANSWIWKSLIQFDLGNYEESIVNLLNSLLFLDPKDERAGMIQDVLKYIIPEKKEEEKKEEEKEEEKKFKFIEEPEINPKTKQTKDPSKKFILSIDGGGIRGIVPCILLTEIERRTHLRIQDIFDFYAGTSTGGIISLALTRGPISLSPREALDIYIGEQRYKLFERWSSNSRTILDPIMNGPDFLLYSAYTRKGIDGELDKIFGGCTITDTIKNRGIMVTTSAENYGACVFANYPISDPYKSGLFRLNEDYSLTLIDDSSFKMAHVAGATSAAAPIFPPLTLEKNDGKRITFVDGGFIINNPAAAALVTCRDISNYSLDDTYLLSLNTSTDNLTPVYNWRANLGVIGFLTQSKNFLYQENQVTANLTNRICTNMIGDRYFRFTPFDPEIDSVSIDEISPENIRRIWNYGVEMIEDLDNQEDNLLNKFCDIVEEYRYANYEFSGTPNPRRFGIGYVTNKVFETTRQQLEEKTKKKEKEKEKEEEKEEEREGLGIGRYRMDKESFKKIDEIFTKQEIDEKELSKRLKKFFDARLYSFLKKNDEIKYANFSRWSKHPSVCIASSVGHLSSLQYYSQTNSPLDSIKGPSDWTALHYAAANNEIDSIQFLIFYDILSSNISEEVALNKLKYMECLTDKKKTALQLAKEEKSKQAIELLTELKKFFEKFIKTNQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L995</accession>
    <name>A0A9Q0L995_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sca1 complex scaffold protein scaa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000119">
        <property type="protein sequence ID" value="KAJ5068185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L995"/>
    <dbReference type="OrthoDB" id="17150at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037474">
        <property type="entry name" value="ScaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37516:SF1">
        <property type="entry name" value="SCA1 COMPLEX SCAFFOLD PROTEIN SCAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1202" mass="141800" checksum="DAC5742372C7C50D" modified="2023-09-13" version="1">MSDLDDLINEEINSNIRKFKTIENDYKENQENKENEENKENKENPIKLIPFFVGFNKKYYDIFFNEQNQDLNNSNSNSNSNESENDYQQNLKKYSPKKLNELPEFPQIDKFKTFVEFEQAVLEWKTLSKKYIGFDEITAKSSEIESDRKISFDHRKSSDSSFKYTDKIMNVLDNPEKNSEMINLSSDQEFSEPLPQFLTKKTSILDENDIWKHQLFIPPPEEEFYSSYEEFENAYLNWANLMNNELKIIPPHPKQISELYGIKIQEKKKKQKKEQTENEKSSDPQKEEKKLLENLDNQVSKHWIWIKNFEKYILEFSYITEMNSLKNIQLFYREEIITNENENENENEKNGKNEKLSIGISSNFFQEQNKDLDVQKWKDHKMFQLTNYRIQEFFSQILLKTQSNIRDFRLNSKPLVGVVNGIIPVGGIQKKPESVETNNIHFDIISSSILIRDDINERLRNRSFLLPKKVNGKNVLFEVPKYDIQEKLDLSRIQKDPEYVKNLQNQLIRLDQLHQINSIKFSNNILKFQNQDILFQKQEIHEMIEDLQTLGSESFYKIFKTSIPLDRFSDFISDFAAIQIHEISYSQIIQNFLLEKNFEYVFELFEQTCSFMSQAKISEFLSTFLESQNTLVKIEEFAEKGNVEFIYSFANAMNILEEIPALIFPLNKEMPFYVKNLFKEPTSEIENYIFIHYCLFLIMKKFKNRTQAFTFAGNIDMFLQFIKQFTKKFHEILASKFTQLYSNFITAISSRSFSISCHYTFLLNHLLQVLDPTIFELFTKNNIKIIDDIRILTRSKYSHVQIFCQKIWETMLNNSNWIGFIVNYYSDNFSNIIGDLSFALKSKQNTQKNVVSHNQENQKPQKASLMAILVDNLFEKLFDSKKTNQLFDILSSKLLTPTLFSNLILVLEGFIASKSQNESLVLFSKFIRMIIQSYSEKYLQNMRKDQQMHLTINISKGSIEKILFIISSTPAILDEVKINLVAALNSMMKIDHFFNDIVKLSGFYSTIIDLFRSTTTFGLSFEIWNLFFETIVYHPGFVDVLAQNKQLQFILESISTTSYLPILIIGLKHLDKIFNMAKDEEIRINKFNQPTRITEKNSLKSIEKDLKNFCDFFLDNSLFVKLHMILKKIEGVSQGLIFVNLSSVYHTIANNESCLKIYTQAIKGEQYSLGFKFMNSFYKSSKNKSEKKNPKNRWRRTFSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9G8</accession>
    <name>A0A9Q0L9G8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HEVIHYF"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="787"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1828" mass="214472" checksum="93B52B63F75109AD" modified="2023-09-13" version="1">MSERSKSKTKSKSKSKHRRNSHKITKKSNLNDSNEINSKKSKNQIENENENENENENENENETKSKTKSRSKSKSKSKHRRNSHKITKESNLNDSNEINSKKSKNQNENENQIENENENENQNENENENESESKTKTKSKSKSKSKHRRNSHKITKKSNLNDSNEINSKKSKNENQNQNQNENQNQNQNQNQNQNENESKTKTKSKSKSKSKQRRNSHKITKKSNLNDSNEINSKKSKNQNQNENENENENENQIENENESESKTKTKSKTKSKSKHRRNSHKITKKSNLNDSNEINSKKSKNQNENQIENQNENENENENESKTKTKSKSRSKSKHRRNSHKITKKSNLNDSNEINSKKSKNENQNENENENENENENQNENENENQNESKSKSKSKSRSKSKHRRNSHKITKKSNLNDLNEINSKKSKNENQNESENQNENETKTKTKSKSKSKSKHRRNSHKITKKSNLNDLNEINSKKSKNQNENENENENQNESKTRTKSKTRSKSKHRRNSHKITKKSNLNDSNEMNSRKSKNQIENQNENENENENENENQNENENETKTKSKTKTKTKSKSKSKHRRNSHKITKKSNLNDSNEINSKKSKNQIEIENQNENQNESESESKSKSKSKSKHRRNSHKITKKSNLNDSNEINSIENDKNKYKQNDKEIENDENDKEIENDENDKEIETDKEIENDKEIETDKEIENDKEIETDKETETDKEIENQNQNQNQNLNQNQNQNLNQNLNQNQNQNQNQNLNPQLMLSLNLSVNFESIYQNLKKRSDFTIYCGKQNTPLYCHQLILISASSYFDNIIQEKNLKEISFSNFEINIIEPVIKFLYSGKLQLDLQFWEFFWQFSQILNLINLIDSIETKIQEMINFENVLQIYSKSQFIHSKNLIQKCSNFIHQNIKQLQEKIKIEELIEKDLLNLLVVIFSKKGFDGSKLILEIEKKWNQNQNSSPKKSNSKNLLFRIFLHFKSNKKLTESENEKIKLIAETSPETLLDLLNEIFPKKTKTKTKTKTKTKTKTKTRKPTLQTQIEDILNQFPKYIKENDQRKRSDLIEEAKKKESKLQSIENLNISNEENQLVGKMKEIEFTIKSMNNFPNSQKIQTDGCSILRVLIEENEKNEFYIAKMKGIEFIIKSMNNFPKIKEIQIDGCFILSNLVINNEEYQNKIRILKGIKSIISSMNNFPENQDIQFYACSALLNVAVIPENQNEIQNLNGIKSIISTMKKFPENQDIQQNASGALLNILEDNKKIQKQFIKFNGIESLIETMNNHKNHEVIHYFILLIFFFIFKKKIKLQESTNKLMIQNLLSSMKQFSKCKDIQQIIFEILFGFEEKIKKLDEIQTISTPLIDLIIQIMENFPKNESIQFFGSGILWNLIILDADKFQNSKIVQIMIQTMNSFPNWKDLQFFCSFILSKITRKKSIEKEIRELKVDRSLIETVINSIDDFSGNESIQENGAFILKNFINNKETQDQISKKKGIKILTRSMYRFKKNKELQSCCCEIFSFLSENQDNLVRFKKEELLKLIFKAIRKFSPDEKIQESCLIILLNIFILNENENQDENKLKIDKVGFKLVIQSMNNFLNNQIIQEQGCGILSRIVQEKTFIQEIKNLKGVNSITEAMKKFPQNLNIQENSFDFLRLVAQEKETRILLNFSIKLIFNGIYQFPNQEKIQEKGCGVLAKLSLEQNNREEITKLGGVNLLINLLTKFQEGEESLHEYTCTLIRYLATNPKNKSEIGKLEGIPKIIYIIKKFPKSQPIQYQGCCALWNLSVNNRQNENKIKEWINRNFFSKILSQFPDDRQVKRVVEQLKNKYEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9U0</accession>
    <name>A0A9Q0L9U0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rich repeat and nacht domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9U0"/>
    <dbReference type="OMA" id="TIQNINC"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="668"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="772" mass="87359" checksum="736E3056491D8F22" modified="2023-09-13" version="1">MSLKIDNFQKFIEKCEKNQRNLISYNLKNRIKSNEQFNLLIGALKKNHTLREIGLSSNAFDDSQITNFSQVLFVNKSLQRLHLDNNQIGDKGMEALAKSLKMNHSITHLNLRLNRITEKGAKHLADVLLGNKTLTHISLRYNSIGDKGVNYLSKSLGKESGVKVLFLSFTKITSKGAKNISQALKSNHSLETLSLQSNKIGDNGMKKLADVLIKNETLFSLNISNNGITNKGANFLANLIAQNKSITDLKVGQNLFDSRGVQVIFQALQKNKTIQNINCLRVDINSTAMNSLVSCLETNTTLSTLVISGCAFTISDIEIFSHVLEKNSTLKTLKISHNKITCSGAAHLIKAMITNKGITELDLSHNLIAIDGSQQFADLLTQNKSLLNLNLEANQIGPAGVLFISEGLKKNYWLTQLNLNSNKLLDAGIEILSEAISVNNSLEILKISNNLITEKGGLHLSHALENNTCLTELSIYNNSLDSNGLILVFDALKKNKTLRILKITRNRAKSSDEKILSNLLALNSTLTFLKTDPELHSRYVKAKLKRNKHFQGSFVQDFLALFERKEESDIEFKFPDETIKAHTIILRSRIGYEYKRLPLILLKQTKQARNNFFVWVYTGYLIDETHSGKKDLHQILSQLGIKNQFKYKQQKSGLIRDFQALYEDEESKDFTIIVENKEIKTHRIILFARSELYRGMFLNVNDDSNRVNDYSGKCYETVKTLVKFLYVNELDPDLPENIIQELVDAQDYYQLNIKSTLPFKLRNLEKLNLKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAD3</accession>
    <name>A0A9Q0LAD3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAD3"/>
    <dbReference type="OrthoDB" id="70707at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="431"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="538" mass="61900" checksum="61EF002E2654E84C" modified="2023-09-13" version="1">MKRKDIRIFGFNTFSKILKNSSSKIKKPIQINLKKEYQIKQIIGSDSIFVLYQNGKAEEYKTNSKKKISIRNEKIEKISTGNKIISILTNEKKVYLSGNIITKSEKQSQNEFINISKRIEDPEDQNVNDVICGAFSVYLLTSKGNVYGIGENGFGQLGNNLNDQKKQAILMMKDVSKVFTGNSSSHVFILNSKKELFGCGNNSYGQLGLDTSIQKISELTKLKNIPKGKIIDIQCGNAHSIMLISGEDGKRRVYSCGNSISNGIYNCGDINSFTLIRSPLLDNLNIDRISSGKGHIEIETDNFWLNVSNYDIGCGYETSFLHYSLISNLNEDFVNFFRNEEFSDYCFVTKDQKRIPVHDIILRYRIGSRNITNLKLLIQSKDEKEAKEILEMIYGNYDIDIDSKQEMKRYKFWKEGLNEAMKRMYYDKESKDFTIKRGNKNVLVHKLVLIARSELYRGMFLSVTEDKSNKVTDYSELSDEAFEILIYYLYTNEIKDNGFKLTKEIINELEIAMDYFQLNESVPNLVTIANELHNQKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAD6</accession>
    <name>A0A9Q0LAD6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Villin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAD6"/>
    <dbReference type="OMA" id="DPNIWSA"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000001">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000005">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF51">
        <property type="entry name" value="PROTEIN FLIGHTLESS-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="5">
        <location>
            <begin position="739"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="802" mass="91326" checksum="F99F99A0B9A94166" modified="2023-09-13" version="1">MTSEFVKFKPGQKPGIEVWRIEKLKVVPWPRPGVFLTGDSFICLHTKKLTFGLGYDAYFWLGTETTQDESGVAAYKTVELDDYLGGKAVHHREVQHHESEMFLALWKGGIEYEEGGIDSGFRHVERDVYKTRLLHLKGRRNVRCTQVPVTHQSLNAGDVFVLDCGLEIFQWNGKEANRMEKMKGLEVVSRIKDDERGGRAKAQIIEQGKEPDEFWKALGGKGRIKTAEEGGDDLAFEKMALSQIVLYRVCDESGELKITEEARAPLKRAMLDTMDCFILDCTSEIFVWIGKGSTDQEKRESMKNAVAFLTKNNRPNWTPVTRVIEGGETPLFIEKFPDWRKVKMPKDIQGPERRIAVKQEQPKIDVSKMHEKQEYKERMVDDGSGKLKIWRVEDFKRADVDPKTYGQFWGGDSYIILYTYLDHGRESHIIYFWQGRDSTQDEKGASALLTKELDDSMGGCAVQVRVVQGKEPNHFLSLFKGEMVVRTGGKASGFKTLKETDTDKIDESKIELFHVRGTNAINTRGTEVEAKATSLNSGDVFILNIPHKQYVWYGKGSNQDEKKTGKHIGDIVKGSRQQQIVNEGSEPQEFWDKLGGKTKYADEDYLQDDPADPRLFHMSDATGVFRVEEVFNFSQDDLTNDDVYLLDTYNEIFIWIGGESNPNEHQKAMETAVDYIKNAPDGRSPDTPILRIVAGHEPQLFTAHFLGWDRKKMGTDPYSRKLAAMMGTGPQDVRQELKKYDIKVFPLAALKKKPLPVGVDPTRLETYLSDEEFKKVFAMDKSAFEALPKWKQNNAKKKVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAX2</accession>
    <name>A0A9Q0LAX2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dactylin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAX2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="320" mass="38318" checksum="C844CFF2AABC333C" modified="2023-09-13" version="1">MNSSNLEERNSEQNDSFKLQIFKQKGVISISESNFQLLKKGKYLKSTEKHRISPKEENLIINQLHPEILFMICEYLSPGAFTRLGITCKYFQDIFNDQTTWRQIAKCYQNFFIFDYLEIKPFYLQDGLSILAFQTPINQEIEKIQIENQKLDFPNLDPTHFKKKNAERGIRLEKYSNNEKIDDSTKEDEFLHHMVPIKASTEEERIKYINLLENPKEEMLEKGRKIYQLFLERKKHWENEMINKKRKETLNNFQTKEIDFFSPILIILFSFGFSIYFILITLKKEDKIDTKLSYQSLSIMIPLFAFFIIQLIETIFMFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB00</accession>
    <name>A0A9Q0LB00_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB00"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17192" checksum="DFA5A8ED11399721" modified="2023-09-13" version="1">MSDQEKLEIVDENIPKSSEKEEIFIDSGLFSDQEKDEIEMEPKEKTKRRKKTHNITYPISFMEVLKSKELRKRKKTAFSALAIFIFGLVLFFMSFPIWKRSSAEGISLFIIGALLLITGGYYLYFIYHAIKHDPGFRFDEIPNYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB41</accession>
    <name>A0A9Q0LB41_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein lifeguard</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB41"/>
    <dbReference type="OMA" id="RYAPMEI"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="239" mass="28106" checksum="4176F812CBBF2D8D" modified="2023-09-13" version="1">MIAENPLILHNMPVLVQYENVQIRNRFMRKIYTTLTIQIMITYIIFRIILSLPLKQREELSKSIILILTTALLTIIFIGLAIFERTNYPRNLIYLILLSFFEALTLSFSLASISQPSIVKTAFKLTAGIFGLLTMFTFQNRFSIDRISTIFFISFLELLLIIFVSILNPYDFYIYPGYYVILMISIVIFCFYIVFDTVRVLDSLNEDEWVLAVIILYFDFLRLFMKILELLSYLAKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBM8</accession>
    <name>A0A9Q0LBM8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBM8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="353" mass="42145" checksum="90621DFCED347D40" modified="2023-09-13" version="1">MKMKIKIKIKIKIKIKIQNQNQNQNQNENENINKIQNQIQNQIQNEEKIENENGNENQNGNENQNQNQNQNENQIQNEDENINQNQNENENENENVEKIENENQNQNGNENQNEEKNEEKIENENEDENQNENQNQNQNQNQNENQIQNEDENINQNQNEIENENENEIGNENENQNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNENQNENQNENQNQNQNQNQNENEIGNENENENENQNENENVEKIGNENENKNENENENGNENQNEEKIENENENENGNENENGNENQNEEKIENENENENQIENENENENQIQNQNGNENQNQNQNEIENENENQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBS3</accession>
    <name>A0A9Q0LBS3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBS3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040144396" evidence="2">
        <location>
            <begin position="25"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="622" mass="70872" checksum="E954C436DB21B9F4" modified="2023-09-13" version="1">MANNFKFNLFQFIFLIFLIEIRLSQVNKQFEFKFNEGKGDIAASLPDQTFFFSGVSGNWLYPSLFSSGVNMTETNPIFSNSIYCNCSDLTQGCGLNSTSYTEQASFEFWFLQPPANNSFYNLFGIEGNSYLIFVNTITDITPPQIQIKIFDQNQNYKFLYSNISSFGFLNHIVFTYKKNGNFSTYYNGTLINSIIHSDGNNYLTILEGQSESMYIEVMSRFMYLGVYGSELSSSYILSRFNNGPPPAPPSILINSLNVQTNKTFQLKDIISLESFTNETNDTFILKTIDIFEPGYGSIYTFFDGIKTNLIYIEQELIVNLSSQFLFEGNLDLDSYIAKWNISLFDKTNNFSTFPNPPYSIQFNVSINHPNPYCSSLSTYCINIDKSCQISLIGNDQYSNLVYAIINSIPLNGSIYQILSNQTKGSKIISNDTIVDYRSFDNWSVIYEYEENLNHSSQQLINFSYFVTNDRGKNSTNCNENIIIQNFLQVNNQKVNLETGKIEGIELECESILKEYNFTVLIENILEANGANFYSDSEGYITIKTGSTLPQNSKMIYILGGKETIITINYSIYEEINSTIYYSTTATLNISIPNSPFSNSPSFLFNSLSISISIFFFSFFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBX4</accession>
    <name>A0A9Q0LBX4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-processing-splicing factor 8a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NENEMAW"/>
    <dbReference type="OrthoDB" id="6709166at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030908">
        <property type="term" value="P:protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRO8NT" evidence="1">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PROCN" evidence="2">
        <location>
            <begin position="354"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="PROCN" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="RNA recognition motif spliceosomal PrP8" evidence="3">
        <location>
            <begin position="1480"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1586" mass="186873" checksum="154459FE145058EE" modified="2023-09-13" version="1">MQPHYLNKHIASSPLFQAKTFEDKSKAWVGINNKKYRKQNQVSYTTAQKLDMPPEHLRKLVRDHALGRFPRVIEPIYRSQWGTMWIMMRREKRDRKHFKRMRFPPFDDEEPPLDYTDNIIDLEPLEPIQIELDDEEDEEVYHWFYDYEPLKDTKFVKGTAYRIWNLTAPIMATLYRLGSQIVSDLSDRNYFFLFDPPSFLTAKALNLAIPSGPKFEPLYRDYDETKEDWNEFNDINKIIIRRQIRTEYRIFYPHLYNNRPRSVEISHYHYPCNAYFKTKDPTLPPFYFDSIINPISFRNVDPVPSEYESKKSKSNKKQFNSRDEILSEEDFFDDDFVLPQDIEPFLEDTPLFTSNTTDGISLFFAPFPFNQRSGRMIRCQDIPLVKTWYQERCPPNQPVKVRVSYQKLLKTWVLNMVHHHHGKPRKKVSLLKTFRQTKFFQTTEIDWLEAGLQVCRQGYNMLHLLIHRKNVNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLIVDCNAQYRLGNFDAFQLADGIQYVFSHVGHLTGMYRYKYRLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPMWRVWIFFLRGIVPLLERWLGNLLARQFEGRVTKGIAKTVTKQRVESHFDLELRAGVMHNILDMMPKGVRTNKSRIIAQHLSEAWRCWGKGTKIMMSNGFYKKVENIKLGDSVLGDDNTPRKVVELMGGKDLLYRIKTIIPNSNSNSNSNSNSKNDSFVCNSNHYLVLTTNHKPSLKTKKHSIKVKFPQVSEDNNLGFKCLKIQSKCFKWNSHWFTNMQNSKTKAKKQAQKILQSLLKRKISAQLVHLKSKKKYQIRISKSQNQKTEHLNYVYGYSKNSKYEMYNSQNLAKLAAEKFFLEKSKENIIWEISVKDFLKFQKKNPKLTSSIRLFRSNEITCFPQKSYDMTQVIDSLYEKMNISFVDKINENEMAWLIGVWLANGKTKKPLIYATKNIQSSFINRLRILSEKMGLKIVFCDEEIENQKDDYYPLLLSTCSGDIIQNGKERANENSKNIFTSILKELQIWKNKNVSEITISNLTNQSKDFRLNLLAGFADSSGYVSGNLYQFKQNSIFHFQKTIFSLCQNVARSLGMTSNLEINEEKKWKSYKVLKNLEMNISEFGVWSIPCVISSKRIHKYELKERTNLLEFEVIPEGYGDYYGFQIDGKNERFILYDSFIVAHNCWKANIPWKVPGLPSAIENMILRYVRLKADWWTSVSHYNRERVQRGATVDKTVIRKNLGRLTRLWLKREQERQHNYLKDGPYISSEEGIAIYTTTVHWLESRKFSPIPFPPLSYKNDTKILVLALERLKEAYNVKNRLNQSQREELGLIEQAYDNPHEALNRIKRHLLTQRTFKEVGIEFLDLYSHLIPVYDIEPLEKITDAYLDQYLWYEAERRNLFPNWIKPGDTEPPPLLVYKFCQGINNLTNVWETSQGECLVLLQTHYEDFYEKIDLTLLNRLLRLIVDPNIADYMTAKCNVTISFKDMSHVNSYSLPRGLQFAPFIAQFYGLVLDLLVIGLKRSSELAGPPQLPNDFMTFPDYKIETKASSQNLYEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDB6</accession>
    <name>A0A9Q0LDB6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDB6"/>
    <dbReference type="OrthoDB" id="47475at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="553"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="852" mass="100912" checksum="C1730113C0CF0B71" modified="2023-09-13" version="1">MKLFFIRFQGNFCVFDAEKILNFKTLIKDVKDNFNIRQKIQAFTYFFQDKTVRISNNSQLVIFLNCVKEQVLLITSEEIPILNVQITISKSGKKVPMNTQKMIDQDPFLSYDLDTQKVFCSSCDKELKNLNSWKLKRHLNCEHHRFKIPFYLKSQTKSKEWVFTNHEKNILRILDHLETFTTIDFYSRKDIPVFRTSLTKKRLFNQIQDKENDLKYGTFCSLLQKQNHQRKVLEMRNLYKSEIQLLDQIILFLDFAVNFQEYRDNWETQEFYHKKSWVIFNITIQFEKQLFYFDYISEDQTKVRFQFVLQSFQDFRYKFNEWQHKRNLLNISKLRIFSDNGGHIKNNFVLGMIFDAFSSQFLDIKVIFFLRNHAKHMSDRHFGNISRNKANFGDITTINSLFDYLSQLSNTTPIILNVNRALKFLYKNPIAKIKKSHIFIFLKGNLKTARMPNTNFRKRRIPIIEQIFQEKEFGIKQNSALIQENYSIPFFNTQMTNSKNEKFFQKTSKIKRKIEFEEKKKSKICAFQNFKIISQNKKNFTSSISICKTGNLRKIPNSHNSCYIASIIQVLLRTSVIELLGLGDISETLSDILQSSEESINITPLRKVIGEHVTQFSNTNEQDIHEFFVSLMDLISNENISDFNVPYDLLYQEFDIHNRAIINDFRIRIVQKVTCKKCKRFTYSFPQETSLVISFPILNGEISISSMLDNYFAEKDLDFSQHYHCENCDQKVESSIKLSLLTIPKYLVIFFKRTYYDSLTQSTTRIGTKIQCEEKINVKSFMFQSCPNQETEMKLLGSIHHIGNANEGHYWTEILETETSSNFFGISDAHIFPVNPFRTKDTFTMMIFTRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE54</accession>
    <name>A0A9Q0LE54_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE54"/>
    <dbReference type="OMA" id="NDKSEVC"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="263"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="551" mass="63418" checksum="B6D1A2EEE10B80DD" modified="2023-09-13" version="1">MNTESEYKEYLIDKYPKLPHKFNIQDKYKFIDIEDDGLKIIYTGFGRDDSEIASIRTENPIPISCGIFYFEINVVSSGDTNYIGIGVSAKSVSLNRMPGWDYYSLGYHGDDGKIFESNGRGEIYGPTYSTGDIIGCCLNCISRVLFYTKNGISLPTAFQQVETKQKLYPIVGLRSRGEIITANFGKSPFKFDIESYFLDHQEKIRNSVFYDSHFISLALNHLIFSHLINRGFANTLLAFSNECDVLGHQTLQKFDIQKMINLIQNRKNISNLILDGKVDQAIDKIQNIYSGLLEKNQDLLLVLKTQDFVESINSNSSNIECLLSKGSNLAKLKEKIISEYKLPSFKKDKTIQIQIRNINPNSNINRNQNIRNQNIQNIRNIQNQNQNQIQNINHQSNNLNISRSSLPYLASLNLHNQNIEILPKEIPNSEKLKILNQKNEKKLQSQNDQNKIINKEIWDNYIHSSKIEQVLGLIAFSQPKKSHLNHLFNQEERLKVSKIINKFLLNYENQPQTSLLEKSLKHFVYTKYSCAKNNIDLGSFAMFNIKEMVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG07</accession>
    <name>A0A9Q0LG07_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid--coa ligase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG07"/>
    <dbReference type="OMA" id="ISMMDEG"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="90"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="688" mass="79109" checksum="2F1C3B6494F41624" modified="2023-09-13" version="1">MGQTESTNKLNRVKGYIPEKYPRLIEEKDGKVSYSIKYEENGETMYRSHMAKDGLIGNWNNSVQTLYENLEATTKTFPDHQLFGTRKYDKKTQKYTDYEWKTFKEFNEERTYFGSGLINYKLKKDDRIGVFAKNRYEWVLAEHAAYAYSFLLVPLYHTFGIPNTRYIINDSEIKTIITEAKYLPKLSQISKDCPTLESIILLNDPENELEEIMKDNKDIESLKSDNIKIFLFDEILESGKKKQHTHQPSKPDDLCSLIYTSGTTSQPKGVCYTHKNMVGTITGFYYMGYPFSDNESYYSYLPLSHVFERSLINSMIALGSRVGFFSGDNTRLLDELQLVKPTIFIGVPRIFAKVYDSIKAGIKKKGIFAQYLFNVAYEAKKKAIENGESYELWDKLVFNKTKQLLGGKIGILISGSAALLPLHQEFFKVIIDPHFVQGWGLTETGSGGTVQIYEDTRNIGLVGPPLCCNDIKLVSVPELNYSVNDFPNPRGELAVKGPNVFEGYYNKKEATDEVMIDGWFHTGDIAEALPNGYFKIVDRKKNIFKLSQGEYIAPDVLEGIYSNSSFVMQIMVYGNSSENYLIGVVVPEKAILLSHFNDERKENEDDDSFFSRICQDPKLKKLILDDMERLGRRENRFGFEIVRNFIVEPNPFSVENEMMTTTMKLRRKAIEQNYKKQLQDLYSQGFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGF1</accession>
    <name>A0A9Q0LGF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGF1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="68" mass="7942" checksum="00B8772DE6ECCF28" modified="2023-09-13" version="1">MDSPSLHRKVSENTIKTESKEIVEDDKNDIEEREIKKTDGKNKKGKVVHEAKSYPNLHTEYTKTEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGH8</accession>
    <name>A0A9Q0LGH8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGH8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="316" mass="37256" checksum="D50F05BEF3A5346C" modified="2023-09-13" version="1">MNSFWIFIIIYGAILFVFVTISYSLFVYRFHLLTMELSKGRQRIKKFENADSVKAKLFALPEGSLNAVLTRIRSRPIDSSEKLLWIGFPSHFRFLSKERRKKNIFAVIGLIGLFFVFYSWRFSQLGWETVFYLCYSGSTPSVVVVFIICYYLKKIKETTKTKNKVAFAISSHRIFLIGNPNEHSIFSWEISKISTIFARDEKQNSKTLVFKFEDEIEEPEFQFLPNVDQINLFIEELKKNLLNNKSNEIDYEKLELSNLQQIWILDSQVIDEIIDEDGFMELFDNRKPIDNDIEDQRLMETSSNKSEIEMIEDKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGJ2</accession>
    <name>A0A9Q0LGJ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGJ2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="332"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="546" mass="63477" checksum="35DA5A978AAE0C27" modified="2023-09-13" version="1">MNDCLFFGANQLPKLFKNEPDKITKPIQFKFENENENENENENEKQNENENENENEKQIKQISSGNFSTIFLFENGKAIEYSSQNDSKQNPKKIQIEENIQKVTVGGWNEAILTIEGNAFAKGENINLKNPNEFINISSLIEDKNDRIIQDIVSGRFSIYLLTSNQNVYGIGSNYYGQLGFDFETLKKTEKPILMMKNVSKIFSGTGSLHIFLLNSNKELFGCGDNEFGQLGLGESIKDETRIKKLTKIQNIPKGKIIDIQCGIIYSIMLIENENQNPKRKLYSCGYYSFNGLGKNEDIYEFTEIKSSLFENDDILDFSVGFTHTLILISKGKLIGFGNNSYGQLGTGDTKSQRIPIQIELPELRFNEEIFNYHISCGYYKSFLYYSPLSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILNYRLNQDQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKKIFKLHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIF1</accession>
    <name>A0A9Q0LIF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIF1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="428" mass="49539" checksum="B1632813A339E392" modified="2023-09-13" version="1">MNQFQFNFEFDQYYYERDYYQALVFDNGSGKMKVGFSGDDAPRAVFPTVVGRPRHYNVMVGMGQKDTYVGDEAISKKGILNLKQPIINELITNWDDIEKVWHHSFYNELCVAPEEHAILLTEPISNPNLNREKITQIMFETFTVPALYLEKSQLLSFFFSGKPTGIIFDMGYSSSRACAIYGGNILNETVQTFPIGGKEIYDNFELILNNEKIFSYYLLDFFQSCHAKFSYVALDFEEEMKKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQKTLKEITDLYGYGKESEEKINEKLGINKFKIPEILFKPSIIGLQDIRIEDTIINCILKAEEELQKDLANNIIICGGISEIKGMKERLEKEIEKSRKLNFKPNIIEIPLRKFSSWIGGSILASSPLFENLWIARSEYDEFGPTIIKKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIG1</accession>
    <name>A0A9Q0LIG1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein tis11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIG1"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="259" mass="30571" checksum="FEBD788856932CB3" modified="2023-09-13" version="1">MANPLVESNQNYSHFAFSLSQNLYNPYFRTHQKFNPKMKKENGKKTTFENKEKSTELSNNYENDYNYENDYDYDYQNDYQNENESENENIKMNQLSFQDQIVKSPKPSPLVSVSPSVPSHPKNQNYVEHSPKRNNKRKKSRTNEKTKKSPINDPSMVNDLFKTELCRSWEETGTCQFGESCQFAHGKDELRPKPRHPKYKTQICKAFHEIGFCPYGKRCRFIHYNLKKNSNINPTSTQLQFLFGKITPSLPVFETFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIQ2</accession>
    <name>A0A9Q0LIQ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIQ2"/>
    <dbReference type="OMA" id="KADDAQH"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="752" mass="84336" checksum="0998FBAAA62E27D5" modified="2023-09-13" version="1">MMMMMIKIKDSDDDEMMMMIDIIMMKIEKMKTKKEKKEKEKEKKKKKKKESSESESENENENENENENENESKSKSKSKSESDDDDDDKKESSKSESESESDSDKETKNKKEVKSKSKSKSKSKSKQKPKSSESDSDDDDKKESKSENENESKSESDDDDDDKKESSESESENENENENENENENENENENENENESKSESDDDDDNKKESSKSKSESESESDSDKETKNKKEVKSKSKSKSKSKSKQKPKSSDSDSDDDDDDNDDKKESSKSESESESESDSDKETKNKKEVKSKSKSKSKSKQKPKSSESDSDKDKESESDSDKDKESESDSDNDKESESDSDNDKESESDSDKEVKPKSKSKSKSKPKSKSSESDSSDKDKESDSDSDSDNDNSPIKQSDSDYDDKDKSKSKSKHQSKSKSKSKVDKSKSKSKVNKSNTSSSNEDESDNNKSENESKSESDDDKKESSKSESKSESDSDKETKNKKEVKSKSKSKSKQKPKSSDSDSDDDDDDKKESSKSESENESKSESDDDDKKESSKSESESESEKSSKSESENESKSESDDDDKKESSKSESESKSESDSDKETKNKKEIKSSDSDSSDKESDKKSSKSDSSDDDDDDDDKESDKESDSSDDDDDDDKKESSKSESENESKSESDDDDKKESSKSESESKSESDSDKETKNKKEQKPKSSESDSSDKESDKKSSKSDSSDDDDDKESDKESDSSDDDDDDKESSNSDDSSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJA2</accession>
    <name>A0A9Q0LJA2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJA2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23810" checksum="334AF769F7F73BDB" modified="2023-09-13" version="1">MNEIIFLGRNKYPKLFENEEEKIKKPIQFKFENENENEKQIKQISTGNFATIFLFKNGKAIEYLSENDLKQKPEKIQIENIQKVTVGGENEAILTKEGNFICQRNKKDRIIQDVVCSTESIYLLTSNQNVYGIGSNEYCELGFDSKKLRKTQKPILMMKNVSKIFSGTTSYHVFLLNSNQELFVCGYNYNSKFGLGESIKEEAIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJS9</accession>
    <name>A0A9Q0LJS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein g(Q) subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJS9"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="173"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="224" mass="25810" checksum="FC39BE6A71267BAD" modified="2023-09-13" version="1">MGSKVSKDKIKRQKRSEQIDEELKKQAEAYKKEVKLLVLGTGESGKSTFIKQIQILFQNGFGPQDFKIYRNVIRHNLIDHTKVLIKGTRKLDIPLLQENNKLAQKFLKEAQLVKGQIPSDTISNIKRLWNDPALKITFNSRSELQIPDTKGLFLDDLDRITASNYQPTNNDILSCRIPTTGVRMLSFDHKGSPWRVIDVGGQRSERRKWIHHFDNVSVTFMLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJU5</accession>
    <name>A0A9Q0LJU5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_08389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJU5"/>
    <dbReference type="OMA" id="MLNLKCA"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="8">
        <location>
            <begin position="204"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="394" mass="45693" checksum="BD73BB06682689C7" modified="2023-09-13" version="1">MINIRKDIIDESYRYKMPALESRIEGRGNGVKTVITNMNKIAEALETEPDIITKFFGFELGAQSKWEKKTLRSVVNGRFDTDDLQDLLYKFIDKFILCQGCFLPELDAKIDRHNRLEFSCRACGKSFYADSSNRLTGFIIKSLELKKQEERKKSKNLQAKKEQAKIDETKMEFQDVEVDENDWALDTSKAAEEMRLHTQLGLLRDPKKTNMKLLLFKFRDFLESQPSPQLISFKIKQVAKACSWNRTTRTLFACELFFSSNMLEQIPKTKEIFSRLMKHKRSQIVLLGYLERFCGEEHRNFIEFAPHILKALYDEDLIEEENILEWAEQTSSKFTSETVFKEIITKVQPVVDWLKNAESESEDDGEDDDGDDGDDDGEDNGEDNDDGDGDDDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKZ7</accession>
    <name>A0A9Q0LKZ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sec24-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_08736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKZ7"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="6">
        <location>
            <begin position="192"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="8">
        <location>
            <begin position="386"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="768" mass="90692" checksum="D99BEAD489B9417C" modified="2023-09-13" version="1">MDPKQNQQQNQQQQNQQQNQSVEDVGLLIKNMVDSLQTKFEQTSEQILQKIDSMTIIDFFENEPIICRRCGGYLSPFSKINEFENNWECSLCKTLNSIPSYYFSILNQNIHQITSNQLIEIIINSNQNINELKYLFIIEKTQKMIESNIFNLIISSILKIIENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENDLFPKKPKCKIGLITFNKSIQIYNFNQNSRFESEIITDIDDIFIPIPESSIFIDIYENEDNKNKLKEYLNIIISSSLNENENDNNFIDDYDKSNHSSFGVAIELGSLILQKSGGKIITFNSTLPNYGKGKFDLDLNLNSNSNQKEKEKFNFEIENQHYQKIGKFCFENKIRIDSFIFRENNINLSTLKEGFFVIMRLRTSQGIKISNVLYGMDEVIMNQNSEIFLPTIDCDQSITFLLEHDSRLKNQTNIYIQFAMIYSNNKQNNEKRKRRIRIFNLELKTSSNLKEIFEKANQEVIISILSKNTAKEIKNYKIEEIKKRIIKKCEKIIGFYQQFCLDRKEKEKEKEKQIKNFKLPKKLKYLPIYCFGLLKNQLLDLEETEDKIISIILYIKTSPIHLILKFLYPILIEFQNQNQNENQNQNQNQNQNQNENQNENQNENQNENQNQLMILNNLRLSSGSLKLKEAFLIDNGLNTILWIGKEISNDFLKEHLNIPSKNQLIENENENEWNISKTIQNLIQEINKENSRNLNFSIISRNSKNEKLFLKLMIEDRTEKTNSYINFFDSLLENKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL96</accession>
    <name>A0A9Q0LL96_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL96"/>
    <dbReference type="OrthoDB" id="5142935at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="400"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="476"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="549"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="621"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="658"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="695"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="731"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="768"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="804"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="840"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="876"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="948"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1139" mass="132495" checksum="A35D3617B51FAEDB" modified="2023-09-13" version="1">MNIWEIVEKNKIELLKEIENIPEKEIKKENKNLLNFAIEKQVSKEIIKELILKGINPNLNDENGRNSLLISIMNKSKIEIIEILLQNKVSINSKDKHNKTALHYSIIYLQNSNLLETIKYLISKGIDINSETDENKTALHFVFEYQKENVELLEIIKYLISKGIDINHKTKYNKTPLHFAFQNQNSKTNEIIKYLVSNGAEINSKTKYGQTPFHLACRYQEANINEIIEYLVSKGCNINSKTNDNKTALHFACQNQNPKINEIIKYLISKGIDINSLTSKDETALHILCQYQNQNQNQNSNLFEIIKYLVEKGIDINSLTLKDETILHILCQYQNQNPNLLEIIKYLVSNGIYINSQNLKNETSLHILCQYQNQTQNSNLLEIIKYLISKRIDINSTNSQNETILHILCQYQTQNSNLFEIIKYLISKGIDINSRNSNNKTALHILCQYQIQNPNLLEITKYLVSKGIDINSLTSNNETILHILCQYQIQNSNLLEIIKYFISKGADINSKNSQNETALHFACKYNPWFDLIKLLIENGGKINNQTKQQQRTPFHLICNYKKEIPIEIIKYLIEKGASKNLRDKRKETGLHFICRNKQKNTFEIIKYLIENNNHMNYKNKRNQTPLHLICQYQQENSLEMIKYFVSKGYDITDKDFRYGKTLLMVVCEYQNHKKSHEVIKYLIKNGANINLLNDNNQTILHIACQYQNENLFEIIKSLIEKGIDINSKTKDKKTALHLICKYQKKNQIEIIKLLIENGIDINSKTSDKFETPLHYICKYQKENILEFIRVLIQNGADINSKNNLKETPLHLVCKYQKENLLEFARVLIQNGADINSKTNRNETPLHYACEYQKVNILEIIKYFVENGADIHAKNTQGRIPLYIMFYDQKADLFEIIKYFVEKGANVNSKTNDNQTILNLIHYRKKENLLELIKYLVEKGADVYSKTKFNSTPLHNVCEQNSFEIIKYFVEKGVDINAKTDYGTTPLHNACQSSSFEVIKYLVEKGADIFTKNSYGTTPLHFACEYKKENSLEIVKYLVEKGADINAKNRFNSTPLHNACRKNSLEIVKYLVEKGADIYTKTSQNETVLYYACEQKSFEIIKYLVENNADINEKNKYNKSPLSISIQNQNQKFNSIFIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMI3</accession>
    <name>A0A9Q0LMI3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMI3"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="2">
        <location>
            <begin position="261"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="479" mass="57107" checksum="BC5668D6098FD65E" modified="2023-09-13" version="1">MRITSEDFSDTRKIFQQIIQNKSFILTILLIFVSFLSFFLPFHFVRNKTNQKPDLDIEEPTTELKILQKMQLLYKKQQEVWETRNFILQLENPIEELKQVLQSKGSSKSKAIEQYLFYFDFLIDLLNYTDPYSSHSNEDIRFIVYPNYNQTPTITTKIISENQIRYEVLYEIFDEKNQKILFNSSEITIGNINYFRNLTFDKFPICSTDNFDINDSKLPNSNNTKTMSNVIIIKKENYEDNEYWIYHFLGTLLQIRPFIKDKGWTLLIDSNTHEIPYQLLNLIKEDFNVKLEVYDPSITYKIDKLMIICNSPFIHPRKFQEIRAFLVKNILKINSNEEIPIYKQENIIYLPRVNNHNERNVINNEEIENYLRKRFGNKLKIFSHKEHQDLKELVEYFSKAKIIIGAHGGAFYNLLFSLSHPIVIEFQGKPFFGELSIFYWISHTTGNEYWIDYTEESGNDLIINLDHLEEILNNVLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMQ9</accession>
    <name>A0A9Q0LMQ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMQ9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="224" mass="26056" checksum="F5C9AB0AC4DE30FE" modified="2023-09-13" version="1">MNPEININNEWPKSIGTITASLTSISSNSQIKHLGFLETDKVILERIPNKKNKIIKVKKPNKTRAFGKIDEQTSSILASLIDSNQILLSARIKVDQDNENGNPTNLQLEIFVFEPFFDKLKEMNQNQNENQNENQNENQNENGNQNENEIKNQNQNENENENGNENEMKQLIELILKENPNQKFAFENNLKNENNLKNENNLKNENNLKNEDDFHFKHLEIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMX8</accession>
    <name>A0A9Q0LMX8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fluoride export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMX8"/>
    <dbReference type="OMA" id="DYWWISP"/>
    <dbReference type="OrthoDB" id="10526049at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="509" mass="59451" checksum="D22EA1FA031FF53E" modified="2023-09-13" version="1">MNKLIPEEEEEEKQTLITKTPLKKQLFVDPELKIFGKIVSRKFYLYFWQFLWNLSLGAFSSTIQFWVPDFYFSDINFANSLKNAIGSFVIAMTGQIAQIKFQYTQTYLMYNAIQNSFCSVFTTFGNVIEDTEKVMYFDYWWISPVFLIGNLILSFFFHYLGVVVANKFKKGVKYSTALSHLDGEDYRMNYEIDNYLTKSSSTIQDMNFEFHPKFSLFQNKESVLPTDLNSDSDLKMSANDLDSESDHENQYQNDHFLDRKRIFLRNNPKMEKNEIKIGKEKEDEQNADNDYGTFQLGKKKKVSFYLKSIAGKTPLNELSEHIEKQFSKKIRHRRLQTKRRHRIIITIMLVLSMLNFLFARFPAYYPTNSIHSAGLLVYYCGITLLLNVSGAFAGNFLTGDLNRVSSVQWGTFRTNIISCLLIATAHNVLIFRYSFSDSFKFVLFINAFISNFCGSESSWAGLIDETVNLFNADISKKFAIRNLFWNLFVCFAFYLVLIYFVRFLLFFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNK6</accession>
    <name>A0A9Q0LNK6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA recognition motif rrm domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNK6"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000034">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein M isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="330"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="418"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="496" mass="58678" checksum="FF5B67199605573C" modified="2023-09-13" version="1">MNPKSFESLFSLAQNQQKNKQNTNFNARNNLNYSNGSNLNDNQKKTQFNSEQQIQQLQQLQQIQQLQKLQQIQQLQQLQQLQQLKQLQQIQQLNQEQKLQLPLNLQLEFQLNLSQQLKKAQEEKEQKLKQQLKQQQEEQKRVLMEQQETQKDLLRKKLIQHNQEQQEHHQEQQKNFHQQIQQQLEQLQQLHLQTLEQLQKTHNDQIKQLELQQEKQKNQQKQQEQLMFQQLLLSNPNLLLLLQSQKFQDLQKSNQSLLNQENSIEEKRKEEMNENYDGKFNQFQNSNRNRRHYLPNRLSSRSRSRSPSPSPPPSRVENILNHNTNDLLGKRVFVTGLSYRIGWNELKNFMSTVGNVSQVDIFYDRDGKSRGSAIVEFENADSAKLAINSLSNTILNGRVVNVRECRSYKKNKYDDRGRRLFVDNLPFSTTWMKLKDTFKKAGSVIRADIIETESGRSKGQGTVIYETKEEAQRAIQMFDESELDGRKISVKLDNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNK8</accession>
    <name>A0A9Q0LNK8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrator complex subunit 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNK8"/>
    <dbReference type="OrthoDB" id="5600060at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="4">
        <location>
            <begin position="191"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="842" mass="96547" checksum="EADC4EFACC23128B" modified="2023-09-13" version="1">MKIFQICSSCTLLKIRDLTILIDFPLTNQFPKKSNLKEKKYLKNIPLTIPYISQRELEEIDVILITNEFGITGLPFITEYSSFKGVIYCTEPILLLGTMLMEEISQGVINSNSFPEILNENFNENFKENFNENFNENFKENFNENFKENFKENENIKRRKKNPKQNIIKDQNIENNLININFEQKKKYQNRVVYSLEDIEKSTTRITTVKFNQEISIYGILKIKAANSGYSLGSTNWILKTSTKKIVLMSEIFLDKSAQKQFSTPLSQSKQLKSSDVIILLSNNLVPIDYPQTENQDAIMIQNLQNNENTQEDDKKKENEKKSKSKKPKTKTKSKSKKKSKGKSKKKSKGKSKKKSKGKSKKKSKGKSKKKDQPNLQTPTTLAKETFPKTTLSNNISKLLDYSQKTLKRGGNVIIPFCSYGIFYDIINILTDFISDNPNIGNVTTYIVSPTSKKFLAYSNTIAEYLNENYSQQVFIPEPSFKFEKLIPRGKLVPITTLGGSYRKEAIVGTGNMQDVMRINPAKNSRVFTSSYQQQQQQTQDTQFISGKIEISNINAKIPILYTHKTQALKEPCVVFVSHPSLLFGDVVSLIEKWKANSKNCLISIDPNRNFEKSLLPFLPMNMESFNVPINKNANLTDFFNFITKINPSTLVIPKQIFKNNNEWIQKFLSQNQLKLEMVVFKHQKTKKISIKEEYEIGYIESRIENIGLNQAHEAKFGAFPTAMMVNVKNYKNSFEKVLLDPMSSDSRVKTQRSLFGIPSLQSIIEHLSLSMNIQGVSIHSENQIHTISFSQNDPIFSNSSLIFNEKNNQTQIICSNEVARQILKKAILKNVSSFGNHQEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNM0</accession>
    <name>A0A9Q0LNM0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNM0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="415" mass="49225" checksum="ACACF0F5C81FD30B" modified="2023-09-13" version="1">MVEVSIEHFFPNPSSDLDFELELQIQTKEYIRPSFIITEKTHIFENKTRKENKVEKIKTNKKTFNNNDLNLTLDFEQNENFNFFHDQFCFSKNCTEKSHFFNPNNNKDFNCVCDDLVLRSYYIKPLKNIPRFFHISPFNNSFENFQQEKFIENENLMNSHFYESNDYLFNLSNNSSNFWENSNESEDDDNFSGKQRKKKSKPKSKSKSKSKSKSKPKIYLNQNQNQNQNQNQNQNQNQNQNQNQNQNQKSKSKNFKRRVTSHKRKKFQEEEDEDSNLFSDSNEFNQELVEKFRKSLSKQPLPKIGKRLDLIAENFPNSIKGWTSDTFENYLKTGIPPERVEITDRVINLLLRLQGKESEMQSLKVPNSSKKIKSKEYRNTRRGLAAFLHRRLGLVNATNHKHGLMIFVKNSQIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNV5</accession>
    <name>A0A9Q0LNV5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNV5"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="143"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="708" mass="83367" checksum="4BDC5DB27F672587" modified="2023-09-13" version="1">MEHFEHFSKSNSNENENSNQIENQNKNKNQIKNQIQIENENENQNQIQNQIQIKNQNQIKNQNENSNQIENENENKNKNKNKNKNQNQNENQNENLDHQKRNFQSNFKKSFSEHDSLEILLDPNQSFQKIKILSKSQNGYLQNSNSDNNNDNDNNSHKTYFNENQFPNSEENHNQDQKITDKKKMEMKIETKTKNQRSKIQKHNHNKNFFYAFVFSRSQKDETNSRGFLQKSVVILTKYPFIQFFSALVSFISNLYFQGVPDILYKIWGDISKWPSKIPRGKIQKLDIMDFSFQLFIPNDQELFPENAESKQKQNFSNNIPINICFPEFLGFELNIYMSFGSFLDDLWILWQLILTGEPILITSPTPSLCNSAVYGLVSLIAPLCYAGDILPYFSVQDSHFRYLSSIFHQNTNSKNSKKNINLQRISSTPAVPLSRKWPSVIVASTNPFISQNALLECPNKLFFGSVEQPNIDISNGIVISKHYSKFKQKLYHKTPLLVPVDSKVLKKLKSKKSQTIESQNNLFKNDLIRKHFHHLTHQFMNPLEQYFFTLMPLRKETIPFYKPPTLSGFSERAFMKFLDQLQFKKMFHSGSKKNWIELYHKFLHSPNFTKWYLLRKKEALLSLRKIYRESILTLDIFEFISNKSDQEKIDLIQILLGQYSKKYVLNDSQMISAYSCYINQIFSSINCKLPESIQIELNLFQQNYKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPZ4</accession>
    <name>A0A9Q0LPZ4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPZ4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="20080" checksum="88D19D02C3CE692C" modified="2023-09-13" version="1">MIYSNRSKINPKLYSEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYREMFLSVTNDKSNKVTDYSELSDKSFQIFEYWTYSNQIKEEIRITKRMINEIKIGIDYFQLNQTNPNLFDLLVKKFNNQNQKKKENKKESCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQF5</accession>
    <name>A0A9Q0LQF5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQF5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="132" mass="15815" checksum="632695253A0660A9" modified="2023-09-13" version="1">MGKKNRQKNAQKTKNLKEIIQRRKQRRKRKGETTTIWRLKCFSKIYGIDYVYICRNGSKIKIPKSFTLKNPNLKKGDLIKIDSRLFRIEQAIGKKRPIDSIRRSYRKAFSDHGFKINKAYNRNYLVFEFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR62</accession>
    <name>A0A9Q0LR62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U4/u6.u5 small nuclear ribonucleoprotein 27 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR62"/>
    <dbReference type="OMA" id="TPNETHS"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="178" mass="21780" checksum="7E6DA5B6547DB4AC" modified="2023-09-13" version="1">MSNLEKEKEKENRNKDKRHDNKQKHRTKDIDRRREKTRERRERHNQSDSDSDIDRKRESRESRESRKSKERRESRERYKHHRTHSSHHKHEKKEYERESRHHRSRKSEPEKSRGQKEQESLLKLYGLPSGFGTTKGQKVTGNITGFARPKTKRKYSQYINKKKRSQLQQNQPNNQSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRT4</accession>
    <name>A0A9Q0LRT4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRT4"/>
    <dbReference type="OMA" id="VVQTHGC"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="257" mass="31040" checksum="08C8309395157FAC" modified="2023-09-13" version="1">MQNKMQNQIEKDNENQIQNPLVNKLNNEIVDEIQNQNKIDKKEQELIPFQVGNEIIIEDEDEDENQNENQNQNQNENQNQNQNENQNQNENQNQNENENQNQIENQNQIENQINENQNQNQNQIENENQNQNQNQNQIKNQNENQNENQNQNENQNQNQNQIENQNQNQNQIENQNQNQIENQNQIEIQNQIENQIENQNQNQNQNQNQNQNQNENQIENQIENQIENQNEMQINENQNEMQINENQIEMQINRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS02</accession>
    <name>A0A9Q0LS02_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="1739"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="1854"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2315"/>
            <end position="2347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="743"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1370"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1709"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2039"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1370"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2520" mass="297539" checksum="D45B9804963111EB" modified="2023-09-13" version="1">MLCKRVDPKNQGIVYQLDFCHIENLFKEFCESISQNREVIQEMLLKSTIFTFLGTLFHVLDPKFAFLILLFLKEILKKNQELVLKFQESILVSDLISLIYNYNTTPTREILGLLLDFMINYGEFSIENNFIIRNPNIALVIFEIYSKNLKIKQNSVENISHDSNDSEILFMEVLKVFDQICGKSIYNISCCCEKGIISLLLELFPKIKNEKLSTIIIQFISRLGSQKILVSELKHYFSLLMDQLNHDNSENNMISNLMLVELRKMIKKKHEGPRNFFDMHEENSVIKLPSFGSNLIAKKFSFCSWIRIEDFVRPFSCYSVDRKNNSNNDEKTHEMEKDYNPRIFSFLTKDREGIELSLEFDEKKKKVVSIVYHIYLNQEDQKNDNEIIVKFLIEMKIKKWYFLVFTQKYQWVHSKIKAKLYINENEKEISNIKLPRKIGNDQDFTNNLIGSNFPFCIEEQKKEEDEKLKNVDKEQKNQKKQVLKNSFYGQMGTIYIFKEFLNSNQVRAIYFLGPDYKSFFYNTEIFQYTGHDLETDLAALFSGKLTKNMLFCHNAKAIKGNLCLNQSPSNIINTSSQISWVYPCIIASVQDIIHCLGGIEAFFYLILGIDKLFEKEEINQTESQINNTKQLFEEILGNIFDVLLNNFDLQEEIVKVNGFPMFANILKRINPKYFSLKFIDILKLFREKILNESFQKEFKTYLLIDHKIWIRLALDLQLKFFETIHIFFQKSNKLEGNKEESITTKIETDQEKNLKSDSNFNENNENNENNENNENNENNENNENNENNGNKDKIKALEIIDGTTKKMENQQTIINLTQVLFANITIFDLVNFLRFYDKIYQEIQQSNQIEKMNDQQKILEISKKLFSMICVLLEEIELSSQNNPIDTLIATCFILKTEYFVEEILKFVHHFILKNSKDTWKLLIPIYLFKPFIYLMSEKPNPKIFEYCLEIIYKIDISLQENQKEIEDLKQRKVSIDKLEDLYFRIHNVLVAKLSIISKEIVNILYNMMLFRTNKNDSQSSVLKNTFILRTICEIYNQKPKLVDPKIFDNLLVLMNEKILKKEKISLPFGWQGWLVSLFKFNNNNNNDNNDDNDDNDDNILKDQNHVNETNFKILNLLFVYSFKASSTIFPKVFEQFLSSVNVIYPGKHLLIRTTIQRTINDLVNQINLDTTKSDNSQLKPQTKTQDIQKNVILVDNLFYLIYVLNGITFSTPEKGEFLEKINEPSQKFSLTEIPKNFSKKMPSLAKLINSKNGTNTIDFSNIQWNLFLEIKDLENIISLLSHFGFFEKSGMTFKKQQERRAIYKIIILLLLFSIKNLDSESLEQLLLRIINLTKNTLNYKSSKIVNAQDFISIIFSFLFFYIHNPENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNENNEDIKQEKLKRNVLLKNFRVIMQANYRFLFGALSSKNRDLSLLTRKKRDSFVFLGDDIDSFENEIMSKKWKEAITKVFSPVINYILREIQENQKRFKQIQEGNYFYIMHLFNYNTQNSEKAKHFINRIQTQSQKLLQNEKTRILTSKLNTYHNRIYFQEFKKMIENSISGKYPWSSNEISFLDKEFEKQKFYVKLSGIEDEMRRQKKLKFYLKKENGNLNGNEQIAKKNLRKANSELSLKIMEITDKSIPQNQKGKKKHNDDNDDNESKSKLKKQKPKSKNDNLFSPNCEIVTKTKTTEGTFEITENSINFFVSIKKIDQQKGKDYSWGIESVISVHKRRYLFQHSALEIFFENRKYVFFNFSTMEERDSFYDKIQKCKMVDIEQQKYVYSGNDPTKWVEKTQMIKRWKLGRITNFEYIMYLNTLAGRTYQDISQYPIFPWVISDYDSETLDLNNPQVFRDLSKSVGALDNKVITYLEKSEKDGKEFVFNYPKFYSTEEIVSSYLGRLEPFTSICLKEKYPIFSSIPKMWEKVKPSKSGEDYHSYYNEKNRSDIDYVGELTPEFFHLPDFLRKPNIFHHENENENENENKNKNKNKNRIKNITKNVKLPKWAKTPEEFIKKHKEALESKYVSEHLNEWIDLIFGYKQKGKEAKKAYNLFPLKLYEENYDFSHLHKEKTNKEIKEEIKRETKTKGQVPIQLFKKKHPKKYSKKEMTQLIIHDFFDWEKLLYIDDFEFSNFKIGKTPIIFTKFSNIHQILLENIPEEIITFDKERIIGNHNWYFLDQKTSSAGFNIQIDPIIERKKPISISFSQDFNNFQQSVAIEKNLRYLICCGFCDDTFKIFEIQNYKLMQSVSRHKDIVNCLAIDLKYIVTGSKDTTVIIWEFDLNEGKVRENPKHIFFEHEKEVKSVAVSIENDVILSGSIDGKLIIHSLIKGKHIQTIILSDKKPISLIKITKEGNILTFSENSNILRLFTINGHLIREAQCSQNIYSISFPHDPNFIFLGGSKHVFEVRELFGLELIRSFDLKQKIHSISINKKGFVVVGLENGEIKIGRLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS74</accession>
    <name>A0A9Q0LS74_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inner nuclear membrane protein heh2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS74"/>
    <dbReference type="OrthoDB" id="118234at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="9">
        <location>
            <begin position="464"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="693" mass="82219" checksum="C068DC1889D61282" modified="2023-09-13" version="1">MDLNSLTVRELKSQLSQMGVILPPTQQKKQFYVEKLLEAKKKQKKQKQKEIEKQKEEKKQKEKQKQKQKQKKQKEIEKQKQKKQKKIEIEKQFEKQKQKVNKFKFQKKSPNQNQNENQNQNENENENENFDLQKIQKKISQRNPLIDYVNSLYEEKMPQLSPQNLNYQQNFQEDQNKNNINIKNQNKNKTNISPSNLNHSYNFQENQNKNKINISPSKKTQKSPTKNNSQLNYLRNRKNQPYKIKQQDNSPRKQINEQKITEYTQYSPYLNEYENKYFKSSPSNMEEKYEYKQEQTNVSEYSIRKPEQKIFKKKTPTKTEISPRNIRRKGPSTVRILAGYFILALIIGIIGGSGYYVVWKYIINKTKYCSTVLDPNQDSNCVPCPENAICESGNLKCYPGYILRNQSCVINDQMVDTLIMEIEEYLDSIYPISFFQCNIQSQIISSDKLEKAIKNKMQFPQETFEEALRQSNSIIIKQFYANESQIEYQPQPYIPYYCNFRNYLLHHKLAVILLILFLSVVSVFTIKIRNKMLLKEEASLISNQIISMLHEQYSLSQKDPNIEPYFAITHLRDTFIEPGNTKMQRILWPLVESLISKDSRVAKEQRIVNSEQKSVWIWTAGNVLSPQKDLPNYSIQKNKNQNQNQNQNQNQKEEENLDQSLIDNFTEEEFFAEKDPNVNPNFYTKIPILEKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTB8</accession>
    <name>A0A9Q0LTB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase trim33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTB8"/>
    <dbReference type="OMA" id="FVINDME"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="162" mass="18503" checksum="D07EDF2A58A835E1" modified="2023-09-13" version="1">MKKGYSAKRDGFSSQKWHSICDNKGKTLIIIKTKDNFIFGGFTSVGFTNDKSKWSEDEEDYGFIKDTNSFIFSLRNDKGDRKSEKFTIKQGQEKYAIYYKSNLGPSFGSDIQLDSDLKSGYSNFGHSYNLPNGIKYGTDGARNYLAGSYNKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTI6</accession>
    <name>A0A9Q0LTI6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTI6"/>
    <dbReference type="OMA" id="ECKGANL"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22272">
        <property type="entry name" value="DPBB_EXLX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049818">
        <property type="entry name" value="Expansin_EXLX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041144">
        <property type="entry name" value="expansin_EXLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040207552" description="Expansin-like EG45 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="4">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="243" mass="27202" checksum="15DADC25C5C8AAA8" modified="2023-09-13" version="1">MILKLFLFVILFSQLFCLFTGDGTFYNATGGGTCSFDESNANPLLVAALNQPDWDGSNNCGRCAKIWGPYPDNPSYKNPVTVQIVDKCPECLSGDLDLSEDAFAMLAPMGDGRIDISWEYVDCDVSGLPGFQIHTKNGSNEWWVAFQVRDSRIGINMISVKSNGVWYDLSRTDYNYFIKSFSSGVGTQFVVRVEGINNEKFDYTINSYIANYTFQTSYQFDASSASINSILFGMALLFFFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTT6</accession>
    <name>A0A9Q0LTT6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTT6"/>
    <dbReference type="OMA" id="IHCHINR"/>
    <dbReference type="OrthoDB" id="2439862at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="165" mass="19019" checksum="A66C34ED43FFE0D0" modified="2023-09-13" version="1">MKKGFSAKRDGFDCDKWHSICDDKGKTLVIIKTKDNFIFGGFTQVGWTNDTSKWREEDRNDDYGNIPDSNAFIFSLRNDKEYRKPEKFTIQKGEEKHALLYDLNHGPIFGGCDIELNSDLQSGYSNFGFSYNLPNGMKDPTNEAESYLAGSYDEWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU75</accession>
    <name>A0A9Q0LU75_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1287"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1530"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1626"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1689"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1725"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1767"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1852"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1471"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1853"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1877"/>
            <end position="1888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1975" mass="223835" checksum="24198AD76D9864FA" modified="2023-09-13" version="1">MGCFKNFFKKVFHRIGKPRFLDFVGDDVIFRTFTIFFLASFYIFIFGRGVRYLLENAEVSVDKIKINVDFFEFPNATQMYYHQSVSAQLRVYKRFESDGVQDCKISVSASSFSVEKAEDWSDLSLLEIKESLPKSIILEGDLVHYSNQDGLANFTNITFISGPEETIKLTFTAVCGRTSQIKLSGPTESLTLSSVTETAETSFPIYLLSKIDDIEILDETSIPINSISFNEDVLLPLSIRFNSDLNNVNLQSSVQIVPQNYRNWTFPEYESFAIVNIGSITQNDTFCNVTFSVSSSTSYRILFTVFAEGVEISTPFALKFNSTVSSINITGGSSSVVEGAAFDSPFSVSVKDSEGGPIAGKYVFAKISQNCDNQQSEYQVPLNNTKVLENSIGYTDSNGTAEFTDLKFSISGYTNDSCDFKIKFVIDGMSSETSAIKVNTSVARIIWIRDMENLTINENGETEVTSWGVVHVEDTYGKGIGKKFVKFHSENLTFVPDGVVSDASGYAILTFHHVAKVNSNGTHELNVSVDTLNSSSKSFNVSFDFNVTTPPATCSEIKLTNWTGNISSGDDVNLSISIFDYLGDPVLTDFSVTVFVDPGDTPMGYAFLKDEAYWNLTNGEGSILAKVFGISMTSVICVVAAEGYVPTPEEYDCRSCFELNITNPIEKVHIKSSPEPTVPIAPQTAFGDSIIVGIETRNNEIIPNVTIHVVSLNGYDGNHKLFGENASFRKRNLSQTLFEITAASEDNTFNLSNFRINYPNFDSDIYELIVFVNGVPSREIAEIFIDSPFTNWTINVTWNVGPYISGLNTTMDQPVARITDAEGKNVSGYYVYVRATDENCTELVNYDTGEVEPVRSYEPSDENGMVTWHVNLLYVWKPNATVIMFFLDNQEIYHENITINATREKLRLSKFEMRPIVYSNKTFPFPIQILVVRDSDSTAVKDKTVIVWDLVSDLWDEWEYLAQATTNENGIATFSKLKVDHNLTMQFDCDDWYPGEVEVNVTTEPTNLVVIQERLNGSIIGYPFSLPPSPLFVNQEAYISSVVVGLYSNSTPISGKAILASFKKNKGDGVLDSSVAGATTDKNGIALFNILVSSGKSEEYSIEFSFNNQFRTETNAFTLVNPIEKISVTIHTNFASGHPITSMPISIISSCSVASAPGDILQTDISGNCFLNHVRLDSISADPECLDVDGNVIVNLKFSVLGIETETQQMRLPSPNQVVLTKAMDSFKQSLMFWGVCLAFVVPFVLNSARKSNKTTYAVSIGLMVLTFYYIPTLIPSAKKVESRQFIALSFFQGILLSLAVFLLVVIVASRISPQVQKWVIKVNFFNERMSNYMNLFRRLLPIGAYRSLRIRDLELMITKAEIDLSDLEKSEDELGKFPLARQPDEIELKTDSDQDDQKKNNNNNNNNNNNNDNELEKESKRRLKITEKDIRLLVRRSTQTFRKTGVINPALQGDTDNQEALDRNGAPKKDGKKKKKSKSKGKRCWRWFTRKMKGIYLKIKKKIVTQKTPHDKYQTYFDFYYPQRMLVSFWIWLVMTSLLILLVTKIIRSSFLNLQWYRQDTIGDRQYTNCFYGKPEPSDYPDSVSIYALELINEIDNSCTVDKGAFDNWLSSFLYDLSRHTIDKVLNAFSICGGVAALLAFLIMLALWRSIFKIYRKRIMLLRQGKEPFRKYHSADPVEVTSYVNLQIWLGLISFVLVWAVCFLILFTIPAVIWLASDKLISRILSYILVFLLVVILYKVVIVMLVQKLIKQFFMKKKRVTNRSAFSLYEFVKFFMTIFSGATQSAKRFLFATLSALTTAVFRLDNETSMDESYSAMIMMDHQTNNPMMRVFINFLVTYWRHPDRILQTIKQSHEKKPKNLDKDNDNDNEINLDNDNDKENQNQKRDLTKYNPVIKSIYNEQIHPITKEPVHIEKMRLKFMLLLSLYANKDIIKLRKHGLEKEKKKEIVLKNKEDIIWKVLDDEPKNIENEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV02</accession>
    <name>A0A9Q0LV02_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV02"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="683" mass="79615" checksum="5FC94C1C19F69833" modified="2023-09-13" version="1">MHRTRRRLLLHPDAILAMHHFRFRNRMDRSGYKIVFAITVLAIGFLCGIGLIFFFSLHSNFVHTPETTGCLSGMEPEVQQKLREADIIRLTISKPPKSKNQNISKNQNYSIKSKNPIFSYEYSISTYNNSNEQIKTTKYPNNQSYEFLLDVINYIEENDYLVQIYHNLLEIVLFISESVDISNISNNISNNLLLFINSSVNNSNISEISKNLVLFINNSNIISNIFKNLVLFINNSNMIPNISKNTNNNEMEISKIFTSSFQILHYFAKYLNTRFDIFPEYKTKNVSYEETLFGSLRNRIYHKFNNNSFAWKLIREYDKLKSTKKNEITDKKENNRKLTVSNTSIFGELKNPFRYLMGIFGELKNRVIEVFAVRPSEYVFSKTNGLFYVPESQFASHNINFYELEIPHNHSCLVQFDIPVLLVKFVFEKPIIINSFQSFFQGSGYIWNRNLILDLSQPTPQIKKTRAESQESANVPKQKTPSVFKAFTKSLFMILVIPSITSIFIQEMLIPSLIRSFMEELSLIPRRAYSSHILSIRGLLFSFMLSATLVIIIDFTNDFILSSVISLSSWGTEIYVIIFIRNKTSMKIFSILSLTIHFAFYFYINMFPFGFTYLLGINCFGLQFFLMVILFYKFELPERQNNVFSPIRRTYFSVPPAPLDSDSINLLENINTNLEIRVDEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVB6</accession>
    <name>A0A9Q0LVB6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mtl1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000027">
        <property type="protein sequence ID" value="KAJ5079567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVB6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="425" mass="51353" checksum="F1CB5BD2D147D906" modified="2023-09-13" version="1">MDNRKFILKVHFTISVRNSFQMFYQVKYLIENLLLENYDKKQKNNQNDVKENVRRNNSLKDHKSYIMLILHLTPIQKDDLFYYYIIYNLKENFHQFIQEIKPLSISQISNPLNQKYINEFNQLLDLLLNDKEIINAFFLSLIKIINSGEKEGLELYEWNIQEIIQNYKRTNSITSYSFDIFVSKISKIFGLMLNNLNLNQNLKLLNNKEKESKEELIIKRIWITILQEYEIPCYEFFLKDKFQNSKFPFSFYIYSLIEDFGFISKDMEVLNELINLPFCECSLFKEINQNENQNQNENQNQNQNQIEIEIENENENQIENQIENENQNQNQNQNQNQNQIEIEIENQNEKFIENILSRYLNDFLIFAIGKTNLEKFNQIRINLINLIELFNDKKIIRLSLKEIHSTFFQYIKSLLDNIFQFIDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVS6</accession>
    <name>A0A9Q0LVS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TIP120 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000018">
        <property type="protein sequence ID" value="KAJ5079983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVS6"/>
    <dbReference type="OMA" id="AYIPHFQ"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5079983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1245" mass="139980" checksum="0336E9BD17325FAE" modified="2023-09-13" version="1">MSSFAVSTIIEKMSSFDSDIRFMGLNDLISELAKDTFRLDYSTENTLITTILKLLSDQNNELQSKAVEAIGDLIGKIKDSQITNMIDRILEKLLGDNEEFHDISALALREIVKSLPKKIPVADRFRVLGSISKHTIPQLLKGVKSTPFPENKLRCIDIIRDCLVYFGSLFQNLHEEISIVTLSHITAFTAPKRVIDCLCHLSVNSNDILFNKIAEDLTKHLTSETKNQFIRAYLQAILAISHVIGYRLAPHLDKIIPSSLPYCQKEKYETDYDLRETCLQSYESFVSTSPKEVAPYIKSFIDICINLISHDPNYLPDDESEDEDSESEDQDESDNGDDEDDSDIDDEVDDDDLSWKVRKGSAKLLSALFRTRPEQLDTFYKEVAPVLIGRFDEREENVKLSVFEAFRELLAQTEAMMSAQKGHLESLDILNDNIDKIVKQLALSLKQTSLKTRVGALSLITSLSKVTPKSLEDQIGKLIPGIQLALKDKSPSNSKLIIHSLSTINNLISNTEPKAFIPHIESFLSVILELTQDKHFKISSEALKVCKNIAIVIKPVENSDQKIDSKKIGKEIYEATFSLLKETAVDQEVKEAAIDSMATILSHFGNELGNAEQALHLLLEKLSNEITRVAGIKAFQLIAESPIKGILNKVLPKLIETLAQLLRKKKKILKQTSIRTLETILKYYGADLPKESYTKLFIELSNLIQDQDLYLAHLTMRLSYTILESYPVMAKQVVDHILPKVLNLSGSPLLQGVSLRTMLTFFSKLVPATKSLLKFDDFIQPLIKLVLEQNSKEISKQIFTSVPQIIAAICQSSDEKEVKKLVSRFVSDVQSNKDQITIILALCALGEIGRNMDLSYVSNLQKVVLGCFNNSSEDIKAAASFSFGNLSAGNMDFFLPVIFERIQKIPKEQYLLFRSLREVISRNADSERGLQIIKPHISKLLEILFLNCENENEGTRNVVSECLGKLALFDPVKLIPELKKHTTSASPLIRTSVVSAFKYCITKDDAADSVIQQYVGDFMECLGDKDYIVRKSALNTLNFIAHSKPALVRDLIPKILSKLYSETIIKPELIRVIKLGPFTHEIDDGLENRKAAFDTMNTLLTTSYNLLNISDFIAHVQIGVDDSSDEVITSAFGILNRLIVINKDVVRSSLDSFVEPLKKIVTKRLKPDAVQQEIQKNEEVIANALSVIVNLKKIPDSERALKFTEFIQQTILRNSDLKAKFEAIEQGKPDDLDDHYLSQSSRQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWS5</accession>
    <name>A0A9Q0LWS5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWS5"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="452"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="554" mass="65100" checksum="FDDAC775E917A2FD" modified="2023-09-13" version="1">MNEIIFFGANQFPILIKNEPNKITKPIQFKFENENENENEKQIKQISSKNIQKVTVGDQNEAILTSERNVFAKGINIKTKEFINISSLIEDKNDRIIQDIVCSAQSIYLLTSNQNVYGIGSNGNYQLGFDYKTLIKTEKPILMMKNVSKIFSGFISYHVFLLNSNHELFGCGWNNHGQLGLGKSRKETTQKLTKIQNIPKGKIIDIQCAQFHSIMLIEDGDENQNQNPKRKLYSCGNYQNNGLGKYIEDTYEFTEIKSYLFRNNDILDFSCGFNHSLILTSNSKLIGFGDNSYNQLIPRDPLDRSVPFQIELPELIFNEDISNYHIYCGYFNSFLYYSSSSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNNSKINPKLYFEIKEIINFNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLYVTNDKSNKVTDYSELSNKSFQILEYWIYSNQIKEEIQITQEIINELKTGIDYFQLNQTYPNLLDLLIKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWS6</accession>
    <name>A0A9Q0LWS6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000008">
        <property type="protein sequence ID" value="KAJ5080538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWS6"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="230"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="291"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="346"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="516"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="619" mass="72099" checksum="032B76626AC0FA91" modified="2023-09-13" version="1">MNEIIFFGKNKKPKLIKNETNKITKPIQFKFENENENENENENENENENENENGNENGNENENENENEKQIKQISTGDFSTIFLFKNGKAIEYLNEYYSNQNPKKIQIEENIQKVTVGWKNEAILTKEGNVFAKGYDTNSKNLNEFINISSLIEDTNDRIIKDVVCGRNSIYLLTSNQNAYGIGSNYYGQLGFDSETLKKTEKPILIMKNVSKIFSGNTSAHVFLLNSNQKLFGCGYNLYDQLGLEETRRETNIKKLTKIQNIPKGKIIDIQCGFAYSIMLIENENQNPKRKLYSCGAYNLNGLGKYDKDTYEFTEIKSSLFENDNDNILEISVGNAHSLILTSNSKMIGFGNNSSGQLGIGNTINQSIPIQIELPKLRFNEDISNYHVLCGFQRSFLYYSPPSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNENQIEKLQEIISTKSIKESNQIFEMIYSNKIINPKLYCEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIDEMERGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX17</accession>
    <name>A0A9Q0LX17_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Serine/threonine-protein kinase fhke-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_14121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX17"/>
    <dbReference type="OMA" id="MIRNECE"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="154"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5080104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="437" mass="49352" checksum="B1E49CC8DC0C8217" modified="2023-09-13" version="1">MEAEYWDIEMKETQTQAKETKTKKALLASLNPSFSTIKIEKNEIKIGRGSSCDFIINDPHISDIHCIISKNNSSGAYYVKDLSTNGTFIQSEKIGKNNSRIINHGDELVLFYGNSRKQNDSNSIISYIFVEPSQQSPKFDFITEMEEDEIGKLYSCQKKLGEGCFGTVYSGIRKSDGFPCALKVISKEKANQQGAMDTILDEVYILQSINHHNIVSVYDVFDSENYVVLVLELVTGGELLDLIAKSTLNEEEALFLFYQILTAISYLHKNGIAHRDLKPENILLKKDSTPHIKITDFGISKVVNEQKLMKTICGTPLYLAPEMLIYPDQGYTFAVDMWSAGIILYQLLTGVTPFNFSFFPNTPFEIQSFYSKIDFDSNSLPKISDSAKDLVRNLLKVNPNQRLTADQALNHPWIKSNREKLESLNSSKPSKKPTIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXF8</accession>
    <name>A0A9Q0LXF8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000040">
        <property type="protein sequence ID" value="KAJ5079085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXF8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="98" mass="11866" checksum="BCAB21EE1A4BE6A3" modified="2023-09-13" version="1">MIENKGINLNLQDKTPFYYLYLNPSVTMEMIQFLIDKGYLQEINTVEIEKELKLWMMNLTNQIIMEQLYYIILHKRNQLIRIFLIILLIQELIGINKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXW8</accession>
    <name>A0A9Q0LXW8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXW8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="17755" checksum="0E2CDEA6B69524DC" modified="2023-09-13" version="1">MEFPFKFQFQIRSWKYFIQNFKFPEKKQIKKSIQKNLEYFLANYLIIISILLMIVLILQPFGFTSLFFPSIFIFYFFIINKGNEIIIDEKKAIFLCILMFIPILQIINPVISLKIILVAITIIVLHALFHLPLRDDFENIEENKENKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY82</accession>
    <name>A0A9Q0LY82_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000015">
        <property type="protein sequence ID" value="KAJ5080040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY82"/>
    <dbReference type="OMA" id="IACFCAT"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5080040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="317" mass="37118" checksum="0325D1A09718D8B3" modified="2023-09-13" version="1">MNLQTDEICLIITASFSLFGSLTLITTFLIFKQLKFFYRKLVFILSVYDFLQVACFLFPGQKNEKICKVQIYLLAFFGFSPYYWTSVIAIISYLKVVKGYPDRKLNIISNWFQLVLWILNTFYFIECFIFSPPLNSPSYWCWNQNEGIIIAAYVSAWIIGVCCIVFYLLTIIRLRKISKILSKNQKLFLSPQYKQIQIQFRMALIPLIYLICIIPGTLEHLFEITNSSHSNSTLLHSFYYICSCLQGFFDFVIFVLFDSSIRHKIFNCCCSNSSQESGLSYQEFDENEKISPFGNFLFSQKNDPRQEILLDIKKDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYN4</accession>
    <name>A0A9Q0LYN4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYN4"/>
    <dbReference type="OMA" id="GIHYPIR"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5080250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="429" mass="48830" checksum="B4AF8943DB426513" modified="2023-09-13" version="1">MTHRSRQTYDHLVVSTRRPPVIIDTGTGYTKMGYGGNIHPSYIVPTAIAVNPSHDQKAAVKKKGAEDLDFFIGEEAIERSKTYAVHYPVRHAQVENWDDMEHFLEQVIFKYLHCEPEDHYFLMTEPPLNAPENREYLAEIMFESFNVPGLYIAVQAVLALAASFTAKKSRKTLTGTVVDSGAGVTHIVPVADGYVIGSCIKHIPIAGRDISYFIQSLLRDHETTIPPEDSLEVAERIKEQYCYVSPNIAKEFDKYEKEPEKWVVTYEGLHKKTGRKWSCEVGHERFLGPEVFFNPQIFSSDYLTPLPEIVDTMIQNTPIDVRRPLYQNIVLSGGSTLYHNYAKRLERDLKKFVDARIEKTIELSQGRLIPAPIEVNVVSHKLQRYAVWFGGSMLAHTEEFFKVCHTKQQYDEQGPSIARHNPVFGGITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYS3</accession>
    <name>A0A9Q0LYS3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extensin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYS3"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="754"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="851"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="851"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="859"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="941" mass="116324" checksum="6AFCDA19DE107DB7" modified="2023-09-13" version="1">MKINQQNNNEINQENNKINKENNKINQQNNEINQENNKINQQNNKINQQKNNEINQEENNEINQENNKINQENNEINQENNKINKENNEIIQENNKINQENNKINQENNKINQQKNKINQQKYKSKDELKQYKSEDELKQYKSKYELKNYKSEDELKHYKSEDELKIEIYKSEDELKYYKSEDELKHYKSEDELKHYKSEDELKHYKSEDELKHYKSEDELKQYKSEDELKNYKSEDELKQYQSEDELKYYKSEDELKQYKSEDELKQYQSEDELKYYQSEDELKQYKSEDELKHYKSEDELKQYQSEDELKQYKSEDELKQYQSEDELKYYKSEDELKYYQSEDELKHYKSEDELKQYQSEDELKNYKSEDELKHYKSEDELNHYKSEDELKHYQSEDELKNYKSEDELKNYKSEDELKQYKSEDELKHYKSEDELKHYKSEDELKQYQSEDELKQYKSEDELKHYKSEDELKHYQSEDELKYYKSEDELKYYQSEDELKHYQSEDELKHYKSEDELKHYKSEDELKHYQSEDELKYYQSEDELKYYKSEDELKYYQSEDELKHYQSEDELAYYQNNLSYHLNTNQGIIYNINKISQRQKDFIRNKSIEDQIKNRTYFQKFIPKKHQKNLKIQKENLDRYLETNRLKLQENYEDIWLRIAKKKLKTEKLEGQIATEYFKLNSKWFAKTNIKNSTVKNTRKTKKENFKEKYLLKFYNKLKAEVPPMIIDEKERKRNYFNSKNSLIIPEKIHESHRNKFWTKEEKAIFFEKFSSNTKNFREISHFLPNKTIPDIIHFFYINKKKPDFQKNFKENHKQKGDKKLFDEGAIKPKKIRNPKSKPKSKSKSKSKSKSKLQKAFWSEEEKLLFFQLLAQNGRNWDFIARNFPSKSRQQVMNFYHNYKRNYDLSEFENHFQNSHHRNKSKKEKIDPEEIYKRIKKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYY5</accession>
    <name>A0A9Q0LYY5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195089at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026171">
        <property type="entry name" value="FANCI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029312">
        <property type="entry name" value="FANCI_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029308">
        <property type="entry name" value="FANCI_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029315">
        <property type="entry name" value="FANCI_S2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818">
        <property type="entry name" value="BC025462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21818:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP I PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14680">
        <property type="entry name" value="FANCI_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14675">
        <property type="entry name" value="FANCI_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14676">
        <property type="entry name" value="FANCI_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FANCI solenoid 1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI solenoid 2" evidence="3">
        <location>
            <begin position="408"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="FANCI helical" evidence="4">
        <location>
            <begin position="618"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1449" mass="167771" checksum="0CF32C6F71FC0AC7" modified="2023-09-13" version="1">MTSLFQKFNEPSKNEEEKRQIIQNLSKKSVNERVSFATEFCKSLLSPFQQDPSIEKLFNHFLSYINDFSPQDLSDLIGLVFRGIFKEGDFEGQPFILNIIPKSVSLLENFALEKQNKHKFIQISCVEGKKNKKLTLSIFRNYIFSFLIKQKWPQNLSISMISMIREMELNEEETTTLLKSLSSKLKESEPQNLPSFIHKLLLIKNNREKTMKIVVKFLNNIQYYFTQTNTKKLWEICAKSIEHINLAARQSPALGKMIINKFKKFSPKNFSAFNITLLFALTYIQRFSTELNGILHKIVNDACDSEIYMASESWFKKIHHEINKREKNNENIPQNENNENIPPKINDTFKMIIKNNAEHKWYHVHPKMLNFATQLIDKFAVVKGKNTTTITATTKWGLTTPGHVMITRNFTTKQKEMIDLAKLIIKEIFSCDESAQRTVLSLIFARIISKTPNSYFYISILHDLVLQNPQAFQQEHHQKTLIHGIDYINLEPSDLLLMVIALNSLLSDSPELFDRMLLALRQMQISSDVDSRVIAVVGLAKLTSVKIPQKLPQIYEAVFWSLRQQGPVKLQFYHQIQEILDHQILLLRSQKEDQNENSQSQYKSQSQPSGEPTLALVSILDTLAAQLSAHFQPAELVSKRDKQMGRIKIDNCIDNSSPPRIVEPIPVLLLCLSNCLNAIRSVVPDSKSREKTIHNYKIIRSNFEKMGIQLAQTNSEEFEFHRDTSFVLTSPLGKINYLIAIMLLGSYEVYISHFATRYRNSNAKKQKYLQLICQLIEKYDSLKILVSVPTKRPKMQSQKKRKKKTNEDEDQEKNVQPIIDLDANTKQRKSHSLENNFYDAISLFDPRVVSFSTVEIAIYLLELLNDKRPEDFLLIGGVYQVYHYAISVMLRRIPLIELDLQVMPHIWSLYHNPQEERQKIFSLYQTASRLLIQNYGRRKIPKYISDIDEEMLTENTQTNTNSIKQDSHNSAPQDADEKTQKKKKPAYPNENLGTMTLSALEKILSQIITFNFNIDNAPSILLNNMFLESSQSHKSSEPSMQKHLQKFLDWIKGLIEEKSAKEIEIFCQIANHVAKVTHEIKDCASWISNFLRNVSISKVNLSKTLLSLSLNIILLSDHLDLLFFIEEIASDLEREFKTARTKMDQEDEPSFFPHFINSKTHPHLANELVKFLNFDILPEIELGIDQDIHTAIIYTDKNISLLVDSLKHVANVITKLLRSFVPIFPTVIKFFQILQKVAFVLEKSPETSPPPNKFQQIFHKESGWYNVLKKNVEVFIDFCYNSKAKNLGIDKISSVSLQIEKFESQLILLSKRFGIKILKRLKLSSYHQVNFEDVPSVNSNSTNSERKSQKKSQKTKEESNKKTNKKSHKKSNKKSNKKSNEKSNKESNEKSKEKSKEESNKESNKESNKSKEELKEESNKESNKSKEESNKKSNKKSNKEKSKRKRRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZC4</accession>
    <name>A0A9Q0LZC4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein coupled receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000015">
        <property type="protein sequence ID" value="KAJ5080060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZC4"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5080060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="325" mass="37799" checksum="249944A8F17E2BBE" modified="2023-09-13" version="1">MKGEEFSTIFGSSLGLTGALLIIIIFLYFKSTKLFYRKLVFILSIYDLFQSLSYLLPGNSNGVICKIQYYLTAIFASTSQFWSAIISLISYLKVVKQIDDKKLNKIHKWFHLIMLIPIIVLIIISAYAHDYDDSKTYWCVLTTESFLLTLYVFIWIYVINCLVFYILTIIQLRKVLKLIKNEKSFSLLAAQKNQLWIQIRMSLIPLIQIIIMIPATIRRLRDIIDPSAPDIIVIDILQSLLVTSQGFWDFWIFVVFDPEMRDKIKGCCCSNLKQKYLQENELSDISTYQKLPNQENGIFSIKNPNFKSSEFKPLIQNSNKEESLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R3Z4</accession>
    <name>A0A9Q0R3Z4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R3Z4"/>
    <dbReference type="OMA" id="FNRWAFV"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="545" mass="63062" checksum="CA74CA1272B5E1FE" modified="2023-09-13" version="1">MSHQNITTEDEFQTTELNTEQELDQEQPQMNPQQPFYQQQPQMNQMNQQYYQQQPQMNQMNQMNQPFYQQPQMNQMNQQYYQQQPQMNQMNQPFYEQENQMNEQMIQDIEKPHKQTSDSNVDENDLGDKFKKPKFNDVWAFFLFIAHLVVLFVVTTRFKSNSTDYNNDSDRSYSGKYVLIVLILSMVCGVIGAFFWIQLMKKYAKGLIKFTFIAGIVFTGLLAIAMFVLGSVVGGIIFLFCFIISIILYRVWAKRIPFSAVLLVYVTKTLQKYPAMITIAFLFGVVLQIAWTFAWIYVAIVTYNISSKYWAIYIVFSYFWTSGVITNLIHTTSSGTYASYYFLKGNMPKDPTFQSFKRAITYSFGSICVGSLIVAIIKTLRWIVRVSESNDNDFLKCICLCFLNCLDWLAEFFNQFAYAYISIYGINFLQASKKTFNLFKERGLNALINDDLINGVVNMAAISTGIFAGIISGIITYFAFNHDKIWIAFSLISLLIALFISLVVLETVTSGVTTFFVCFAEAPEVIQELDPNLSEKLRSTYKFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4L7</accession>
    <name>A0A9Q0R4L7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4L7"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="693" mass="80214" checksum="5F2416AFEFD0BEF6" modified="2023-09-13" version="1">MDTNTMNTNTMNTNAMNTNAMNTNAMNTNAMNTNTMNTNAMNTNAMNTNSMNTNTMNTNTMNTNTMNTNTINTNTMNTKTMNTNAMNTNTMNTNAMNTNAMNTNAMNTNAMNTNAMNTNAMNTNLLNLPNNQLDALLSDECTIDLKALLKTEAALSDFTIICGKNLKEFRCHKLILSSRSQFFHSLFRQKDLEIINFAEFEYGIVDPVMGFLYTGEIKIPQQSFDSYHKLADKLILPKLKIKIEKDIQQSLNQDNLVDVYSKSKRISSDFLIQSCGDLLTQNIDQMIQSNQVQKINQHEVICFIEMMLLNKTNNKLKLIPGLVIEWFKYNNLKPQREYSKLHLKNLQIPFYKSIFQLLEHIQYLYPISDYQMYQIQKFSFFPFETVVEIYNHHIKTSIQAKEQKLIQEKKENEKKEQSLTKKEAELSSKEDQLSNKQQELTKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKKETDLGKMEKKNAKEKKENQKKEKELTKKEAELGNKEQELTNQKQELVKKEKELLEREKDLLSRIQTDEATLLHYFAQKKPINKDLLNHFIKSGVDWNKQDNNLSNNLIILVIYLINFIIIIEFDIEFDFLHYFLFSIHLSYIIFYFPLTINYDIISNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4U9</accession>
    <name>A0A9Q0R4U9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-zipper-like transcriptional regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4U9"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052124">
        <property type="entry name" value="Rab9_kelch_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647:SF1">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="439"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="582" mass="67975" checksum="542EE6A6CA02948A" modified="2023-09-13" version="1">MLSHTQWVKIELKKETSKIWAHRAVKVGNLFYIYGGYSDSYFFSPDLFVINLDTFEVETYRAPENCSPNKRYGHIMFYHDSEIWIQGGSSTTLSSNFLIFNISNKQWRIYEPTPAPPPRYDHSHILHNGNLYIFGGGTGNDNFFNDFWIFNFEKQKWEQIFSKGDIPSQRVSATLQPYKDGFYIFGGKEKGGDRKNDLHFYDFVTNKWSLVKTLGDPPPPRTGHCSFLYNSKLYVMQGWNGGEPFSDIHYLDLITKRWNILEMKEHPDARVAAGVYFDAESATFYMHGGYVNSWNYLNDFWCLSLDSPSLTKDLFKMLNYYNLSQKQFVDFRELCLQMPFLQTRLDRYKQNFLELLIANPINQHAYPVLLSYLITGTLLYAKISTNFSEIENDLLNLTKNIPIFEPLQKLLKHEPNSVSLSNLQLTNDLKMYYSEESTKDFSIIVGSERIWVHKDILYSRSELFRGMFESVLQENQTNFVSDYSQKSIDSIREFVYFLYTDELRDSVSFNVALELLDCPEYYGLSSKKIANLAQSIISENLTLENVDKALKIAEQFEKDNLIEICTDFKRKHQKPTSNLNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R539</accession>
    <name>A0A9Q0R539_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="850"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="850"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="907"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="970"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1286" mass="151368" checksum="AC3B9808DCE45BD3" modified="2023-09-13" version="1">MASDIIQSITFIIGFFKSRYDSYKGNIDEVKRLLQRIDALKNPIEEIKQIQTSDFLFSTLKNVNETLKKIQEMLQEYDTKSKLKRFFTSKTNQKAFQEESIKLDSYIGDLSFELTSLINREVRDLAKIFRGIEKHQNKVEIQTQEYFQNLSSQISQLSSTNQNSNQNSNQNSNETSNETLNDYTNLEFIKQKFGLEERSGTIICTTCGLKPTEPILFNQFFKALLDFSTADPKTQIKLLFKSWDDDGNDKLDEEELTNALRNLYILVSCLRLKDSIGSLNQYVEKLNEEKKKEFNKIIDDFVNKNQIESKIEELFENVKEETTQSYSLKQSLDLNKSTKNLINLQQFQYYCTKPGNFVIEFLNVIKTVFNQTVGKTFFSDSVPVLEINSNSLSKTDLSLLLKIKEDFQNILHPDKILEDPVLVNSQNYEKSDIDKIIEENPNNPKLPDTNKTFDPKAIQLNPGEKKRIQKWKTKRIKECLDQANIIREKDPDIAYQLLSFAKKLDSSNLEIIDLQISLLEKILKIPEEIAQKQFEKAEILFNQGKLENIEKLLKKAIDKTTDPELTEQILNLLLKCYNHNGYFDSSKPLEKISKIYETKISLSRIYLIQHKRQEAKKILVELESKNSNLHHDIQNYNPYSTKTSSNQYLEIYSLLISVDELLGNIDALSNWYLQKARILNQRNDSDCIQYFKKSHKIQPNNIEPLKELITIYNSVNDNINESEIHTKIGQFYSTKFNYEDAKQYFKKALICDPNNSEAFDSLFNCVQNQNRNQNQNQIYELIEFIKEYKMKDQDKKFLQTISQIFKTQLEFVEKEKTNGKKNEESKKKEKEILNLKLENQKQQEEITKLKQENENKNQENQKQQEEITKLKQENENKNDENQKIKQLEEENQKQQEEITRLTQGNKNKNDESKKKDQKIKHLEEENQKKQEQITRLTQENENKNDESENKNQKIKQLEEEITRLTQGNKNKNDESEKKDQKIKYLEEENKRLKKGNKNNNRKIKNKDQKIKQLEEENQKQQEEITRLKQENENKNDESENKDQKIKQLEEQNKRLTQGNNKNDESEKKDQKIKQLEEEMEEFKAMKSEFPAFLNSEIIQDIEYVKKLKEWINDNDFFSKMKLGFSAIRDGFNCQNWHKSCDNKGKTLVIIKTKDNFIFGGFTEVGFTTNTSKWSKKYRISHAHEGFILDSNAFIFSLRNDKGDRKPEKFPIQKGEEKNAIWYNYLERGPYFGSAIILNSSLKPHISNFGEVYTLPKGIQYDTDEARSYLAGSYNSWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5V8</accession>
    <name>A0A9Q0R5V8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5V8"/>
    <dbReference type="OMA" id="EYPEQNM"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000024">
        <property type="entry name" value="probable tyrosine-protein phosphatase At1g05000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5067571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="177" mass="20432" checksum="B09145C44F2EC65C" modified="2023-09-13" version="1">MNLENKKDTGNYDVFIPPINFSMVAKGVYRSGYPNSKNFPFLKKLGLKSIIYLCPEEYLPANQEFIDKNNIHLFHYELLGNKEPFVDIPESVICSALEELLDTTNHPVLIHCNKGKHRTGSLVGTLRKVQNWSLTSIFEEYRRFAGAKVRLLDQQFVELFDTSKIKWPPAKNLPSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R602</accession>
    <name>A0A9Q0R602_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-related protein rab-11c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_13067</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R602"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000274">
        <property type="entry name" value="ras-related protein RABA5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5067289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="762" mass="88353" checksum="42CB95C37217DCB9" modified="2023-09-13" version="1">MLNSFLFDFFNSSESEEIKAKNQERFFHLIFLLPFSLLKLTFLATILLIHDFIVFFTFPTRFIRFLASFVSSIFSSERKRKFEKIIKNDILFVCYLMILVITVYVFAVNFNSSIIYHQIRAQSQLKLYFIDNFLMLCHNLLSSFELTLFHYLNFCVYNLNKQKIKRHLIIVLFILFITNFVHVLLLSIVVLTLNAIINSDQSILTAFLVSSKLSEIRRTLFRNFSPENLFQIACSDIVGKYQRFVFLLIVYARNLFGGKEVRFSFESLNFLVQFFLIDLCVDCNLNNLNNLNNNLNNNLNNNLNNNPKNNLNNNLNNNLNNNLNNNLNNNLNNNLNNNLNNNPKNNPKNNPKNNPKNNPKNNPIYIIGETHNLYQRMGFSFLSFYNVIAVFTIKALIFLGGTETEGGIILNIIPKKHLNATTELLSHQFKIKNWKIFFNLFNIFVLIIIIILLAILIRFILSRIIIIYSKSLISRKGLSEKQIPLTYIKRWEMFGRKLIYCNISLGIMSYENKEKLDQVKESHQEDSTNESDENDQKIDDITQPHQIEVDDDENQKEDYLLKILLVGDSAVGKSNLLSRFCTNEFDPNSKSTIGVEFATKSVKIKETLIKAQIWDTAGQERYDSVTKSYYRGAIGALVVYDITNHITFEHSNKWITAVKENSHPNILILLVGNKIDLKEKRQVTHDEGKKFAEENGLAFIETSALDSTNVEEAFLTILENILEAIQQKNANLQQQTTQQNQSHVISQDGLMIQEKKRKRKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R640</accession>
    <name>A0A9Q0R640_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R640"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="473"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="593" mass="69322" checksum="EA4E2A48B6BA5374" modified="2023-09-13" version="1">MNEIIFFGFNQNPKLIKNERDEITKPIQFKFENENEKQIKQISSSEFSTIFLFENGKAIEYLKDLKQNPQEIQIENIQKVTAAFVKGVILTTEGNVFSLGKKINPINPNEFINISSLIEDINDRIIQDVVSGYNSVYLLTSNQNVYGIGSNLSGQLGFDSETLEKTEKPILMMKNVSKIFSGNSSYSVFLLNSNQELFGCGENYFGQLGLGESEEDKIYKLTKIPNIPKGKIIDIKCGFHHSIMLIENENRKRKLYSCGYYLYNGIGKKNENIYEFTEVKSSLLKNDDIIDFSVGDYHTLILTSNSKLIVFGDNYYGQLGTGKRKDKLIPIQIKLPELRFNEEIFNYHVLCGYLNSFLYYSPFLSFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLQEIISTKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNGIQITKEIINELKRGIDYFQLNQTNPNLFDLLINKFNNQNQNQNQNSNEKKCLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6G9</accession>
    <name>A0A9Q0R6G9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6G9"/>
    <dbReference type="OMA" id="SPLTMMQ"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="540"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="573"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="606"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="672"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="706"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="739"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="773"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="806"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="840"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="873"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="907"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="941"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="974"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1272" mass="145549" checksum="B0819EDDE1BA6461" modified="2023-09-13" version="1">MEIRKIIEKNNIELLKQTKSIPKTELEKEEKPILHFAIEKKVSKDFIEELISKGIKTNSFDKKGRNELHIAIINNSGIEMIELLIGKGINMNSNDRKGKTILHLAIKYTKNNQDLMKIIEILVEKGMDIHSKDRKGRTLLNYACQYNSIQIIEFLIGKGLNIHQKTTPSLIFEKSVMSNLHLACKNNSLEVVQYLIEKKFDVNQKTNLHESVLHFACRKNSLEVIQYLIQKGADLKTKTNKNKSPFHFACKSNSLEVINFLFEKGFDANSKTTLGKSLLHSACRKNSLEVIQYLIQKGADLKPRTTQDESVLHLACKSNSLEVIKFFVEKGFDIHQKASFGKTALHFACEKNSLEVIQYLVEKGLDIKAKTNKNETTLHFACGKNSLEVIKFLVEKGVDLHARTNFGKTASNIACQKNSLAVIKFLVEKGVDIYTKTRWGETSLHLASPKNSLDVIQYLVEKGLDINEKTSYNETVLHYASQSSLSLEVIQYLVEKGVDINAKTNYNETSLHLACQNSASISIIQYLIENDVEIDQKTGGKKTAFHLACEYNTFGVIKFLVEKGADINTKNNQNETALHLACRNRSLDAVKFLIEKGLDINAKTNENETIFHYACQTNSLEIIEFLVEKGVDLNAKNHQNETALHYSLQFNSFEITQYLVEGGFDINAKTIHNETPLHFGCWDGGRLETIQYLVEKGADINAKTNRNHTILHYICENSSLEIIQYLVAKGLDINAKANRNETALHFACRSSSSIEIVKYLVEKELYINAKTDFGKTALHFACESNSLEVIEYLVEKGVDIHEKTNSNETALHFACRNNSSFETIKFLVEKGLDINAKTNENQTPLHFALQNNSIDSIQYLISKGADINVVTNRNQTALHFTCQNDSSFGIIKFLVEKGVDLNAKTYQNQTVLHLACQRHLSIEIIEYLISKGVDVNEKNNRNETALHLACQKNSFDVIQYLVSKGADIDMRADGNQTPLHFACWNNVSLSIIQYLVRNGVDVNAVTHTSETALSIAIHNANENVIKCLLDNNANIFKLERKQITKQFIHLFSQLYSFNQDLNNLLKSTDNFSDYQIQSIDSFKFKAHKLILLTRFNNDESVLQRFARICFQKPKEERFSQRRRRKEKEQEKEKEIISQLFKELGFDSNWIDSKKGREGIIKDFEKLYEQNETKDFTIICEKKEIKVHKLILIIRSELFKGMFQLNVQDSSNKVHDYSRKSFETINQLIYFFYHDKFDDTKVTQSIIEEFIDLKDYYQLNQNSIIDLILKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7C4</accession>
    <name>A0A9Q0R7C4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 35 member f6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRT-like transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7C4"/>
    <dbReference type="OMA" id="TSIVWIC"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013936">
        <property type="entry name" value="CRT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08627">
        <property type="entry name" value="CRT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="355" mass="40247" checksum="5CC2695D4D40031F" modified="2023-09-13" version="1">MLISGTVNTITKKAAFESRAKGLSDSKHKFSKPFFLSLIMFMGETLCIFFYLRQKRKNKRIAKYEILDSKEPEKEEKLLINEPEKIKKENLQDNIVMKDTRSKFWLFFLPSLCDVGGTTIAGVGLMLTTASVFQILRGSIIIFTALLAFIFFKRKFHKYHIVGIIVIIIGLICVGISSIKQEEKSNSTNVKRTVYGIIFVVLSQLVSAIQFTIEEFFLKSKSDVTPLRTVGSEGVWGILEMVLLALPIVYFIPGSDSGDHYENSLDSVVMMGQNALLLFFVLFYWISIAFYNAFSLSFAKQLSSSCSLESWSSSFGEKLTLWSLLQAFGFLMVILGTILHNHLWKIPFLEPHDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7D8</accession>
    <name>A0A9Q0R7D8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7D8"/>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="541" mass="63030" checksum="2AB7297CDE89F257" modified="2023-09-13" version="1">MDNGIEVCIGIIGRGGVGKSSIVRRIINGAFSEQYDPPIDDEFFRICILNEAVITTKIHKFVYQEFPYLMDRWIRECHSFALIYSVLDKSTLEDILEFHKQIQLVFDVEDYPKILIGNKSDLTMKRVVKTKEGKELAKKINCKFIETSAKTNENINQLFYESSLLAFEELKKKENENQKNQNKKKKGKCLLIIGLFGNGGVGKTAITRRFIRNIFIEDYEPNIEEAYRKIVDLNYEKILINIFDTVGSEEYYIIDWRFQVIRIVFVYIYSITDRNNYPKILIGNKSDLFTKREVKTKEGKELAKKLNCKFIETSAKTGENFNQLFYESSLLGIEELKNNQNQNQNENQKNQNKKKKGKCLLIIGLFGKQGVGKSTITIRFITNHFIEEYDPTIEEEYKKEIELNDKKIMLNILDTATAEEFYSVYVRWARYSQVVVYVYSISDRDSFKRMKKIQKMIQKIKKNHPKILIGNKSDLTMKRAISIEEGKELANKLNCKFIETSAKTGENIQQLFYESALLGIEELENPNQNENENKKGKCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7F1</accession>
    <name>A0A9Q0R7F1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_11466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7F1"/>
    <dbReference type="OrthoDB" id="8192811at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04519">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="36"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="566"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="967"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="907"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="919"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="935"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1078" mass="125598" checksum="B0C32103C17D08B7" modified="2023-09-13" version="1">MNNNLSFETNSLLNKIKLNPDISILKQTEQENINQLSSYEILIRWVNFQAVKSGQNNPVRNLGKDLSDSITLSYVLAELEPEINFFETLMEPLKQRASTLLDLLHKTNYSGMFCTPEDITSGNEDIIVTFLMELFLWRPTLTTKKSIERLQESIEELTKEKEQNYSPKLEDLLSQFRGEVVKKQEPVLSKREQILSQTQHLESFKVKVSENERKNELLDNEIENANNEYQHLLEKRKKLEMEINQKEKILNEEIMKKHNEQKLKQQKLKEPKYITFLSFVENSNELLNEFEGFFKELGFLFSSFQSDLPEIQDEAKKLLKTICDVILLNSENMNMPVSTKILLKAIFAIINKNTTSPLSDSGIEKIRHMITFLDPKNDSMIFHTLDQINLTLSNEKLTNKINIYRSLQALFNNFYFSQKFRNAIIHKLLSLFPQTIQDPKLMKEMKRIVDLQSQNSFFGFPNFELVEQSISSFLKLQKNMNDSPKNIVQLAKKKAIGKTIRMIIRRIDKRTTSEFGNKESEDSEIISEDSNPIKFEKRKEYLSLFLNEDDFDFFIEILSRKEPISYIDSIAENLFDFLEPFGVTMPVIKTYILEEVFQGENPRSLFQTMNVGTKILLKYILTYSGNYLKDSLSDFIEKLSKTSFNLEVDPKKPEYTSNQNQLLERFSNIKQLFGGMFQQVINSKESIPIEIQVICYYFKNITLLKFAKDESLFSVGIFFLHILLSNVLQNPQDFEISKVQLTQHIKRILYIFSIILQNLSKGASFENETEYLSPLNDLLLKYMFVTREFFISISEIPKTNQSFSENFNIEQVFGIDSKNSSLSFLELFPDTELDPERFASEFIEIVYGSLSNNKEFFSPFGVKYSTTISEKVNLATQNLSSLNRSFASIQLLLTELGKILSTEKTSENLQKIQTKKTNKNSNENEPIKNKSPTPKQKKEKPKKVKKPKKSQVESSLLNSWLDNLTAPTEKEAFIQHKNKKLGWKKRYIVLKSYYLAVFQKNNDDLSSPIDVIFLDTETRMFFAKPSDSKKKNSFVLVPKQDEKDRTIISCENKQDVVDWLSILRKSRNKVRKDTFNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7V5</accession>
    <name>A0A9Q0R7V5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha- and gamma-adaptin-binding protein p34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7V5"/>
    <dbReference type="OMA" id="HEPNEEY"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="419" mass="49261" checksum="90E86BA1D7023BD4" modified="2023-09-13" version="1">MLNKVLICGLNGVGKKTLLSDILNNSNNENVLEIENKYYSAKISFSILEINNIEKEKENYEEIQALILVYKNSKKNTIDDLIEWFNQNNQIFQLKTILCIGNHFENESVFSLDDKYIDYFIDNNIEHLSFDFINQNKKEENSQTKSLLNDQHEPNEEYANIGRLIECLETTQWNEMEMKDFRKKNRIKSNEINLNEINSNEINLNEFELNEKNLNEIKSNEIKSNEINSNEINSNEINSNEIKSNEINSNEINSNEIKSNEIKSNEIKSNEINSNEINSNEKNSNEINSNEKNSNEINSNEINSNELLNQNLQFESNFAEDVNDIDEFFREEFLKKNTEKKSIAEEDMEKQFDEFEKIMSDVLRFKELDKQMDFKTRQENATKIILELSKMMGFSDDDLDDDLDDLDDDQNQNQNQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7W4</accession>
    <name>A0A9Q0R7W4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fluoroacetyl-CoA-specific thioesterase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7W4"/>
    <dbReference type="OrthoDB" id="10265835at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025540">
        <property type="entry name" value="FlK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054485">
        <property type="entry name" value="FlK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934">
        <property type="entry name" value="BLR0278 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22636">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fluoroacetyl-CoA-specific thioesterase-like" evidence="1">
        <location>
            <begin position="49"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="18200" checksum="7BE40ED613B209D7" modified="2023-09-13" version="1">MSIQSKKKLQNSLIPKQILFRTFASKLKPSEEAKRVLKIGGKGVKTTFVSKDLTTNRTGKENDDVLSTPSMILLMELASVEAIDPFLDKSFATVGFHVNVKHLARTNKGATVTTESIIEKIDGSKITLDVKAFEIDGNKKKLIGDGKHRRAVIKFDDDNDKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R896</accession>
    <name>A0A9Q0R896_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adiponectin receptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R896"/>
    <dbReference type="OMA" id="IGNACDY"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5070824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="301" mass="35874" checksum="39FBFF6735B12CB9" modified="2023-09-13" version="1">MNSVKERSKNKKTQKQKEKEKEKEKNEDKLRLYSITEIAEQRRGNKFLEKGYRNNYTFKMSIQSIFTIHNETVNIWSTFVPIFFIIWWAIRVYSDEKIQKSSQTAKIIFAFFVFGCLICLVSSTLFHVFEAHSRLVTSVLLKFDLSGIVFMMVSSFYPPIYFYYYPYKIVRFFYLSTISSLGILMLLSIAGFDFLEKRRMIRTWIFVFMGASGLAPLFHSIFLLPKPVYIDLIVRVMIMFVLYLIGVIFYASKIPERFSSPNRFVFWATSHQFWHLFVVVAMFEHFLTCARSYNYYLLNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8P6</accession>
    <name>A0A9Q0R8P6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stromal antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8P6"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="218"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="922"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="708"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1119" mass="132560" checksum="2D630B262038083C" modified="2023-09-13" version="1">MSKEKEEEDDDDLKPKSVKKLFKSKITSLISPSFKEFKSKKFSVSNLTKRWNNKFKSNLKNGMVDLLNSILQISKVKFQIKNLHFKDEKKVLQEFKKKTEKRIQLKESYFSNSFKKNYRKFWKQIAKIFKEKEQEKENFDLFYQWLTIISNTNNIVLRYLSTFTGLVLLSEIISRLNSIDQELSQKKNYWNEKKQDKSMKNELKTLLKFVSDLFKSFFEMRIRDSEFQIREMCMNYFLKWALIRPQFFLMEQRIYCIGQMLFDKKKEIRLSCVHLLQKLYSKKKHFEHLTNFTKDFRKRLVEMLDDKIVNIRAEMFVLMNQIYQIYPPKHQEIEKIVSLLSDFNSRVRHEAGKLFVDILLTKEVESDLKRIKQSKNSKLKSLYLLDRLIHLLKKHSNTSQYEIIIDSIWIHFDALDDWEIIVDLLLMDQESLPKEDETSPEELKITKKLISKRSLLIDLLKMVVRKAANQNLTESRSKFVNYYQPTKISSKLIKEKKKKSHKHVSSVIEKYHQLLEKFQPETEYIPIIVEILGYFPLKVIVKSQQQNTFLSLLRKTKDLFFKHNNLAVSQACVNLLKKIIDLNKPISSKVEIILTELINEVKDGFIDSMKDFEEIIQRKESDSDSKSQIEAQLTRLRSVSQQMIIGFYFDQLYPLLKRIVVLSVSMADDLGIQMISDGYYCMHHLLIWKFGEIVQKEKTRYLKEKSENQNQNQNENNENNNNNNNNNNNNNNNNETEENVDENTKMIHKFVTKRDNFLEYAQQLFEKGSNEIKRALFDILSSCFMLYSHQVNNLSFTPEITTQNKLLAHFEEEIQRLLDDSQQTNKMQDQTVESIFHLLSQMTNLILVGSVPLAFSSNLMAMYEWEFPNKSATQEILRKVFRKLISTHQNNPNLRRTIIFEALKNDFTKCLERIEEIKEMGNQEKKEDEYHSDYESDYKSDSENPNQENNENSNQEKKDKKIEERKSQFIALSRSLANILSKEVDSTNFEIGQLISNGISYARQSFPTKVFFFEGLKEFFPKIHDGDEFNSVINFLNANLVRTTLEPEIEKLTEWKNYAKLEKRKFITSSKSSIGLQSVPTTGKKEKTKINENENENENENEYVSPNEDDYESPDENQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R940</accession>
    <name>A0A9Q0R940_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">M0811_10269</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000088">
        <property type="protein sequence ID" value="KAJ5071426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R940"/>
    <dbReference type="OMA" id="WVTIVAR"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF94">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="27"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="425"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="142"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAJ5071426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="510" mass="59115" checksum="8AF9CF4DE83B0919" modified="2023-09-13" version="1">MTGIYQDPFSISIKYQKKKPPKIIRQYLFGEVLGEGSYGKVREAIDQTTSRSVAIKKMRLRRVRKITNGEENVRKEIQVMKKLSHQNVVELIEVIEESEKEVVYFVLEFMNAGTLRHFIEEVMGFNCDDFFNENLRNQIFEKNQDELKNESKSKSKNESKSKSKSKNESKSKSKNESKSKNESKSSFEKNLDKLRNESKSSFDKNQDKLRNESNSSFDKNQDKLRKSWKPKPKRFIPLIQIRDFLRQILDGLEYVHSRGIIHRDIKPSNMLLNTDGVLKLTDFGVSEIIDISNNKSLKDIDLIKATSFGSPAFQPPEIAKGNESLHGFKSDIWGVGVILYVMVTGSFPFYGFPVHQLYQNIEKGHFQIPSFVGPELSDLIRRILDPNETTRFSIQQIKNHKWMNMELPSEDPIKISEFHPHQYHDTNGKSTDNITSLSNINDFNEDFDSNSDPNFDPNPDPNFDPNFDPNFNHNHNFNLHSPSDIEFFQSDSDVPPFQNQKKHSHCCFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9F0</accession>
    <name>A0A9Q0R9F0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9F0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052884">
        <property type="entry name" value="VID_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35261">
        <property type="entry name" value="ORGANELLAR PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35261:SF3">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="578"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="99703" checksum="329D862F44286EAB" modified="2023-09-13" version="1">MITFWKHKGQKRNKTVFQFAFIFLSKFSMIEEIVYLKWSRGGRKGITNETFVNESGYARFQEEFSIPATLFLDSKTGKLLEKTLSISIFSKKSNFPVGKIHISISKIYPNEEPNIEEYPIQLKNEKVYQPTLVIATRLTTNNKFKIRPNLLTIPIILEKIDYFEAKRKGEEREIYSSQKYSEFTNLTSLVSITEYGSESEKQSDLDSKEIDNENFPALLEDLQKLQKHYEDLKLHGANTKNGEQITETTQPKKIIKEKSVPVIISSPSSKELSSFSDDLLPKDDNNNENNNNNNNNENNENNENNNDDLQQNQFEISQEKNQNQNQNQNENLDKIHKINDFKIENKPPVNINNIYSDIDLVFESVDESQNFDQLQSQFEQKQSSLSREVESIQTSQRTESAKRRRLIEEQRDGIEKNKLKIIRLNGQLRLIELLRKERFLIENTLYFNEYGFSNGFPISVCLIIKFLIKFQAFSFQNQILSSEIANSFKLLIRVSRKSEEEIVKFTSFFENQSENENQNQNQNQNQNENENENENENENENKNENQNKNENENENQNENENENQFEKQKQNIIYQFKEEIIDLFSEVLSYYLVVISNQTKFFIRRIFFGTLNRKSKSQKSRYENPKERENLLDYFSVEELINHLEEIIYTLSSNFIPNEIINIFLDYLFEIVDDAIISKLLIFSRYCNKERGEHIDLCISKIDDWCNKNGHSNLVQKLSQSREISQLFIQNFQSLLSPNSIKTSSISQDKFAQLKENFGIIENTPKPKTLVDQIETQKKVEPEIKLSLTKKSFNYFKQQIKSMNFSIYSIEGWDRTPIPKKLSDHQEFGFLSETDEILRMHFRDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9M8</accession>
    <name>A0A9Q0R9M8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sjoegren syndrome nuclear autoantigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9M8"/>
    <dbReference type="OMA" id="ETKNEYD"/>
    <dbReference type="OrthoDB" id="295355at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033362">
        <property type="entry name" value="SSNA1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661:SF1">
        <property type="entry name" value="MICROTUBULE NUCLEATION FACTOR SSNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661">
        <property type="entry name" value="SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="116" mass="13935" checksum="266627AE0566E57A" modified="2023-09-13" version="1">MSNQAADLQNYNNELVRFIERLQEEKNKIEEQINFEQEEKVRLEEELKTIESKLVFIKESLTKKVQTRNQINQTLKEGEKQFSKIVGDCHQLLDFLHRAYSQRPIQKKNHFDNETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9V4</accession>
    <name>A0A9Q0R9V4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9V4"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="175"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="227"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="290"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="407" mass="46820" checksum="8C230FEB57447B45" modified="2023-09-13" version="1">MNDCLFFGENQFPILFENEPNKIIKPIQFKFEKENENENENENENENENENENENENENENENENEKQIKQISTGNYSTIFLFENGKAIEYLNENDSNQNLSKIQIENIQKVTVGYQDEAILTKEGNVFAKGKYINPENPNQFINISSLIEDKNDRIIEDIVSGAYSIYLLTSNQNAYGIGSNNYGQLGFDSKTLQKTEKPILIMKNVSKIFSGNSSIFVFLLNSNQELFGSGWNEQRQLGLGESIKGIKIDKLTKIQNIPKGKIIDIQCGDDNSIMLIEDENQNQNPKRKLYSCGKYSYNGLGKNEHTYEFTEIKSFLFENDNILDFSAGNSHTLILTSNSKLIVFGYNFYGQLGTGDTKHHLIPIQIELPKLRFNEEIFLIIIFIVKMKNHFFIILLLFPILKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA04</accession>
    <name>A0A9Q0RA04_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.1</ecNumber>
            <ecNumber evidence="7">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="7"/>
    <dbReference type="EC" id="2.7.7.18" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5071983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA04"/>
    <dbReference type="OMA" id="HFDYELN"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1 7" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="8">
        <location>
            <begin position="31"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5071983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="244" mass="28447" checksum="F980F60CB45A312B" modified="2023-09-13" version="1">MQNLTKENYIFPKQKLQLKKIEKDKINRVLIFCGSFNPPTIGHLRVLEDIANHFSLLDQNIIGGYISPVNQKYKKKDLTVGDYRIEMCDLATKSSSWIMLDPWEALQDEYIRTKISLEHFQKEIDTILEKEKIEEKVKVSLVCGSDVIESMIAPDTFWIKEQVIELTKKFNIICGLRDTTADNLKEKISKSYLEPVQEYIHIIKTSPMSISSTMVRNLANKKLSFKYFVLDPVMDYILKNQLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAC7</accession>
    <name>A0A9Q0RAC7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAC7"/>
    <dbReference type="OMA" id="ASAWRIQ"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="7">
        <location>
            <begin position="550"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="8">
        <location>
            <begin position="1004"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="967"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1194" mass="141738" checksum="96905327E7BF29B6" modified="2023-09-13" version="1">MQNLKLKIQSIQIKGFKSFYQKEIIEFFDPNFSVICGPNGSGKSTILEAICFVLGVNPSDIRTKNQENLINEKIISSKNNQKCSASVVLNCALINSENKIMKKIFFKRKIFQVILKKRSKNKNHSEKNQIQIQNKFSIKKSNLNSKSNNENTGKKRKKENRNSSSFKEIKKKELMRKYSKYGIDPKFLDRFVVFQHKTSNFVEKGNKSLCTFLEKIIGTESLKNEIEEKDKEIQEINRNILELSSKINQIEKDRAILQPKVESWNNYQKERSNLFFMRKNYFTIQMKRNLSIIQGLNNENENLEEERRKIEKKSQNKDKEMKQIKKKLKEEENIKNEEESKIFENWKNVNQISSEIGKKEALDSKLKNDIKKKKGNIQDLEGEMTNLQEKQKELKIGINKMKEEIDSLEKKKETKTNQIEKKKQIELELFQLNIRDGFQEMEKKIENHLKKKQKWEEEKAILENETKKESKLMQKQKEIEKKKMEETNRKEKEREEMENKNSQLESQIQKKEEDLSELEKKKKRKEMELKENHQQSLSEQMINELKRGNPGIYGFFKDLGRINKKYLIALNSVLKNNLSTTILVESREAASEVISVFRKKKIGIVKCQILNELQSPPIQNNLKSKGFPLFSYIECEDKFAPFFYRFLRNWNIVEDRKDIPQSHHSQNFVLLNGDLYFSDGEISTGFLVSKRNNRMKRFEIKDKQIRTKSNESLIPLERSEKIEFKIQEMRKSILDLQSVIFGLKEEKENTQNIIKEISSDLRTMKGKLSKISQKIRDYELDLEIKQRDSSCLNEKYEILGKDEKGINFTEYQNLKERKEKLEEALVSCLDTKELLNSKRKKLSKKEGILLNLKAEMKMKQNLKNKKEEQLDQKKQEKKKIDELVDELKNKEKEVKKNLRDMKEFVLRIEKEIREMKREWEKKGKEREDLGNHKAKIENEMENKRMLKTQMEEEMKEVEKELERIEKEINQGEMGKEKEKRRERETEKSLEEKEKRIEINNLEKDLSLQKEKKKLESERRKLKMEWKKHVELRDKLEANRFELFDSSMKEINEELSKIYREINAKSGDCFLQYSKIQANTFLEGVSFHIKPDNTTWKMFRNLSGGQKALATLALTLSLQKKYSSPIFVWDEFDSSLDVSTIDRVGKFISKISQNENSSQFIVVSHSSQMYEKAHTLIGIFHHQETTKSVCLKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAH3</accession>
    <name>A0A9Q0RAH3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAH3"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="475"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="625" mass="73628" checksum="A18600B9A125F020" modified="2023-09-13" version="1">MDLEKETEQKLNDVWFLGRNSFPDLIKNPELQITTLFQVDFFEQEKRIIQIAMNWRMLMILFENGRAFEYYNDSSQTETKIQIENIQKISVGTRINAVLTKKGEVFARGNYINSRNQKEFINVSEMIEFSDDKFMIDIVCGADTAYLLSSQGNVYAVGDNHSFEFGCNLPKESQKPICIKSNVYKIFSSGNCNFAFFLSRKQKLYGCGRNDRSQLGLGKDKRRQMIKMEKIENVSNIRIIEIKTCSSYSVIFGEDEETGEKKLYLSGITGIYPNKKKKTEEFIEFKSPLFENDDILQISVGNTYTFFLTSNRKLFQFWESTFDHLINNKTEYQPAKEFDLSHLPFDIFSYQICGITENFFLYSSFFSNLEDDLNNLLQRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINESERIEETMKRIYLNENEKDFTIEKKEKKYKFPKLILIMRSELYRGMFLSVTEDDSNKVTDYSELSNESFEILEYWIYTNQIKEGSKITKEILEELERGMDYFQLNPINPNIVSSTIDYLNKNHNNNNEKDNNNNDEKDNNNNEKEKGKDLNSHISEDLKKKNSNCFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAS1</accession>
    <name>A0A9Q0RAS1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAS1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051476">
        <property type="entry name" value="Bac_ResReg_Asp_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46630:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="68591" checksum="5D2327C2699D677B" modified="2023-09-13" version="1">MSFLSLISKQTSTTKIEFDKALIIAKENNNENQICQALGKLTNFFYSSMQNINQALKYSQMWAESSQKCQDLDMLRDSLSTLCCTYFSVNQKENAEDICAQFKELLIDKLELDKSSKSIKTLISNHGTLGLLYQTIKEQGKALEIFQKGYQLAKQNPEIMQDSVLSKFMDEIYKNALLLGKFSDAFSIVKEKISLLEKQNQKAKLLDLLEEIASLNSLIGWPHESARMLENALEVAQKISEENPKKENIEKEFSISIKLGETMGIIDHFPKAIKYLNEALSKAQAIKDQVNECKIIDEIAKLYASYNQYSETLIKLNELMSKMEEYKIDNDRVSIIYRIAEANYKIGNYKKAQEFVSKCLSNFQETNFFQIKSHPKLDYKKRGTIIEYDAYLLSFQIESALNNYKSALQAGLKAIDLVNDGVLDRKYSWNQTKEYIEQERKASKLKILEYLNPIAIKAGEFEKAEQMIQETINLGHQVKPEHSILFQSAYSLLAELHMKNSKPELAVSALEKALEYDERLLDFDKCFKVIHSIQIAKMLEMISTKKNFESIKEYYNQAFDIMKRMEPEELKIVQEQTFENKSTIKVKLETQFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAZ7</accession>
    <name>A0A9Q0RAZ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-secretase subunit aph-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5073003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAZ7"/>
    <dbReference type="OMA" id="DTNNYLH"/>
    <dbReference type="OrthoDB" id="16451at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="299" mass="34316" checksum="0D29C7D664DDFB68" modified="2023-09-13" version="1">MTLVLFFGCLFVAFSPIIALFIFVIYKEAKLLIIMLAGAFFWLLSIFIASILWKIVKPLQDENAWSIAISIVAQEGVRLLLYKIFIKLEANIYRFATKQTLETEKSYLKGSLACGVGYSFAYVLVMYGSVMTHSTGPGSLFTSECPKISLFIVNALLAHNFGILNILWTIIIFISFKSLKNKKENKKIIYIFAITLSLASHFLLSYLTLIKNCKVSLLVNYLISIPLAIIGYFFIKKYYRNKKDFYQSQINETQKDEQTIEVIKPQENDQKQDLTRRRVPNDNTSDDEPVLFDNDIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBA6</accession>
    <name>A0A9Q0RBA6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001255">
        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14890">
        <property type="entry name" value="Intein_splicing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1463" mass="170690" checksum="C81F4B1A17970FE7" modified="2023-09-13" version="1">MAEELLDFSKEAFNVDLFDQVVNTFYYGTGEEQNLAQNFLTQFQEHPESWRRVDVIIEFSQSNNSKFLALQILERTIKYRWKSLPQEQQDGIKDYILRAIMNLSEDSERFRANKIVVSKLNQNLVEIVKQDWPKNWSTFVQDMIKAGQISLSTCENVMSIFKFLSQEVFDFNKDQLTTSKTTELKNTFHDEISSIFEFCQYVLENGDENSLLTATLSTFLSLLNWIPLGYIFQTKIIKLLTTKFLSNPETLDLALQCLTEIAGLKSEIAFDEEFINLYQLATQTLSQHIQPTSNFLDIYDHGTEKDRNFLRTLSIFLTTFLKHHIKILEKSPKILQDDIKNSLTIIILLSEVYDIDMFKICLDYWYSFASDLFHENNRNFPMYRNIHIPQHNYYHTNSYPQYNNRNKSKRGEYYESILSKVRLVLISKMAKPEEVLVVEDDNGELIREYAKDTDAIELYKSMRQSLVLLTHLNYQDTQIIMLEKLKKINPYSFSWNDLNTLCWAIGSISGAMSGSEEKNFLVKVIKMLLSYCEQTKGKDNKAVVASNIMYIVGQYPRFLKTNWSFLKTVAMKLFEFMHEPHPGIKDMSLHHDQKVIIRINNSHTVVDSIGNIIDKLMNQNENIQKFGDSSVLFPNQKFEILTVNENEKVDWKPITAFSRHKTSQKLIKVSTKTKRSTIATKNHSFLLRDKSSLKPILGSNLKANIDRIPLLKKLIIPDSYLIKYVDFNSNSNQNLIELDFPLGFLFGAYFNIGKIEENKNSLIYQSQQNPNLLKYLQSLIQFKFDIPNLQTSNSSTSLKILFKPLINFIDHFSSKFFNSINEDNIINEKLKYPSSLFSLLLFSPLNFLSGFFSGFYHSNQNQNQNVNLNQEINIEIVNESFDFSEMLQMILTRFNILSQISDKNYFGLKIIGKNSIRFLEMIKLNHFVDNDFEYTNYMNDLINSKILTTSKLNLQEETEIYNQIPFNNEQEVAPSFYLKSNKKEANSFGSSLESSYSTYEMKSKLIEMEKELEQISQESKNILNHLENTNNNKNWKIDEIEKEYKQTKEYLIKKIGELKQALNADVFYDLITDIQEVSLGDGEYVYDFSVESNETFMLFNTIFVHNSCDTFLKIATKCKLQFSKKQDGESDTFVEDTISKLNLITSDLENQQVLTFYEALGIIISSARKSEKEKLVEKLMNHHNTSWSQLLSLSKSDENTLNNIQICKDLVYILRANVRTSSTVGGAFIQQFNFIYEDALFLYKAFSVLIKKIISSEGTQIVKSNQIRNMKAVKKEIIILIQTFFQKCEDPQPLMEEFFPRLFEVIFDDYKNNFPEARIPELLLFLSIVISILQTQIISYIPSIFESTFECTLEMISSNFEDFPDFRFNFYKLLESINKFSFDSLFMLTSQNFKVIVDSIIWAFKHTERNISETGLSILLDLFRNVLLRDEILNDFFQTFYLSLIQEIFNILTDTFHKTGFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBD1</accession>
    <name>A0A9Q0RBD1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5074007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBD1"/>
    <dbReference type="OMA" id="NPNETIC"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="409"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="699" mass="79347" checksum="B84EB26A7CF72EFD" modified="2023-09-13" version="1">MTTLTENNNIITTRQEIKLTLPIAQLFEVLENFPDIPQILINSLTSFNYLLSSNLKIKNKISELDKISDLLKPMLQYKNNQKIQLLSCELVSKLSNDHTKNIQSIAQEGGIEAVFEALKKYPTDTQIQAEGCLALAHLAYTPENQTKITTTYHGIDYIISVLQRFTNNETIQNNCCLAFANFSFQNSENQEIMSGEPVNQVISIMKQYPESKNIHLNGTTALVNLSISTSNQNRITFLKGIPLIISSLTKFQTEALIVQKSFVALANLAYNNTRNQQEISQHVSLIENIMKNSSDLIIQEKAFLLLSNIAVNKNSKSQIVNSNLIEFAVNAIDTFRSENNILNYCLLFLANLAYNENQIQQKIASLSGLTKVLDLMSTCNNYDLECMSCLFLVNLSVHPFNKKIIADSNGIEQFLALMQKHPNDPQIQNKCILALANLSVAKENQTKIRELGVDIIFTLKDNIAFQSNLAIQTKLLILLVNLSYQNEENKKIFISRNVLGWIRDLMDRYTQPETDLRIQINCCKMISNVANYLDVPTIISVLSTMKKFSDPLIQDISSFILEFYVLKKTNPNETICLDILKSTLNTLQEYPNYEGIQEKSCSILEYFSKENQNPDYRILIRNQAITSLFNSAIRFSTNPIIFRSSFLTIVYCAKFIPVTIDSLLTEKQINTAKEIFSDSKIIQEHQDLLSLAQFLFDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBU7</accession>
    <name>A0A9Q0RBU7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytochrome-interacting ankyrin-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBU7"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="547"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="647" mass="76176" checksum="453EEA71326109EE" modified="2023-09-13" version="1">MKKQLLNICKEKNPKNLLEKIKSSIKKGTDINAKTKLNQTPLHLICQWQKKNSVEIIKYLVEKGTDINAKTKLNQTPLHLVCKFQKKNSVEIIKYFVEKGTDINAKTKLNQTPLHLVCQFQKINSVEIIKYFVEKGTDINAKTKLDQTPLHLVCQWQSRKGFEIIKYLVEKGADINVKTTENQTPLHLVYQFQKVNSFEIIKYLVEKGADVNIQNVLDETILHLVCKDHSQKGNTCEMMRFLVEKGANVNSLQYTKETPLHYIFHYQEKNVFEMVKILVEKGANINAQSENSKSTPFHFAFSLPRKNVFKIIQYLIQNGADVNIKTAQNRTPLYFAAQNNREYLIEILLLNNANIYDLLDTQIKQEYIDLFTQIYSFNQDSQNFLKSNDNFSDLGIKSNDSFTFQAHQQILLMRLDQNETILQQFIKNCSQKSKETVEIVLNFIYSGIYDFENFSKILTDFLHLQNRYNKALKNHLKLILPFEQFHEENKEISKIKENHLNKIEKQKEIIESFFKEIGIDSDWIEKKSRRKGILKDFTKFYHQNETKDFTIIVDEKEIKVHKLILMIRSELFKGMFQLNISDKSNKVHDYSKKSFETINQLIYFLYHDEFEETKLNNQIIEELYDVKDYYQLNPNSIIDLILFDGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC94</accession>
    <name>A0A9Q0RC94_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC94"/>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="113" mass="13756" checksum="D7F609A1A3FDD747" modified="2023-09-13" version="1">MDKIIIISIIGNGGVGKTTFTIQFCYSQFKFYDYYYYEDWNDYYKRGNYEKTDGFIVVYSINDKNSFNELQNYLKEIYEFKKVDDFPIIIIGNKNDLEDQRVITKRRRRRICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCH5</accession>
    <name>A0A9Q0RCH5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome assembly chaperone 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCH5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="265" mass="31362" checksum="A8CFF23E8CB6F7A9" modified="2023-09-13" version="1">MFSMLHYLYSLNEDLIRSPRNLDYDDEQIQLDNLESNQMDLNFENESIIIQPPEFLIIAMPGFGNAFINSNYPKLEKLTSIIDKNEKFKQKINLFQPDSNIIITLLNQKIPDEKCRQFVQFFINKIQPKKIIMFDQIYLEPTQFEELISKKENQEFIKIVETSEHKKIRKELNLASLPPPYFLQNFSASLITQAEILNIPSCVFVSLQERQTLSFEPFFAIDKILIPILFPQKNFSEIPEKKIREKYSKEISNFNSFHPTKDFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCK9</accession>
    <name>A0A9Q0RCK9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription elongation factor a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCK9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="417" mass="48926" checksum="3A904E1965024CAB" modified="2023-09-13" version="1">MAEEVSEKKVSEFNVTLLNQRFEEVEKDCQITLNEKKITFTSKNEEHTDQLIQNKIKTHPKRSGVIQLTISDQTLILEFEPVESLNDFLEYIRLQSLETEAPPNQDDGQTPKPTEDEIKEKDFTVDILDKKFEKAADGKIHLDQKNISLFFESRTHTHEIGKGLKLRAHPQRTTVILVSFEKKQSVCSRLKETFIVSFESETIRSEFFEIFKHFSSILRETVSKPEEKQEKTEEKEKEAEKKEDNQEPLPEDALSFNVSVMNKQLEKIDDAQFIFSKTKIKLSSNKESHEGIFNKKTKIQRSNKDKDVVKISISKPKKSAWSCMSIDSFIIKMQSEEDANNLISNYESFQKLIQPQEKKPEKKEDEKEDEKEKEKEKDDEKEKEKDDEKKDDEKKDDEKKDDEKKDDEKKDDEKDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCL3</accession>
    <name>A0A9Q0RCL3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">20 kDa chaperonin, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Chaperonin 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein Cpn21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCL3"/>
    <dbReference type="OMA" id="KERPMQG"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000001">
        <property type="entry name" value="10 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="124" mass="13926" checksum="D805BFCD3DE1AF05" modified="2023-09-13" version="1">MLSLFKKTPTKKYPLAQLFSTNKTDLIKAFEPLFDRVLVKRETAEQRTKSGLYVPDSMVKKSNQGEVIATGTGRITHDGKVIPMSVKKGDKVLLPEYGGIEIKNFGDDYLLYAEAELLAKFKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE51</accession>
    <name>A0A9Q0RE51_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE51"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="484" mass="57336" checksum="1AF217A1DAFCA607" modified="2023-09-13" version="1">MQTYLNLEKLSNDLKNLFQNQNQNENQNESYFDFEIICEQNQISFKTHKSILSSRSQYFKSLFKSKMKEYQENKLILKDVSSSILFPILNYFYSGKIEINLENAIQILIFSSKYLIDELIEISSSFIKKNFQIETIVDILKLSESMNLNQLLDPSYQFIFENFEEFIKTSFFFELEENHLNSILLNDELSINEFELFQSIIKWGKHKLNINQEKELEKEEKEQIQIQISNIIDKIRFIDFTNKELKTILKEDLIPNQISEKLIQFQKLDENDKNEKELKQFIEKENSLIFKSRLGLHSSSIIEEKKHFNKLKEWINDDEFFYKMKKGYSAKKDGFDSKKWHSSVDNKGKTLVIIKTKDNYIFGGFTQIGFISDQEFWESKDSGGGWIKDINAFIFSLRNDKNDRKPSKFEIKQGGRSALFYRLNCGPKFAGDIDLNSNLQAGYTEFGYMYQLPKGMQPYKDEARNYLAGSYNKWIIEEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG46</accession>
    <name>A0A9Q0RG46_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="4">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_05891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG46"/>
    <dbReference type="OMA" id="TPSTHDM"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05467">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32518">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32518:SF3">
        <property type="entry name" value="4-ALPHA-GLUCANOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM20" evidence="11">
        <location>
            <begin position="108"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="11">
        <location>
            <begin position="259"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5077369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1052" mass="124438" checksum="22D7D69523425E0D" modified="2023-09-13" version="1">MLKLIFQLLHNKNETEHWITGSLPQLGSWELEKAKKLKIQTEIDSNTLLSQIEINIPLISRENYFQYSYLRKQNEKFIFEQKKNRKLKINSNVEGKRFIQDEWGESITKSQGKIIIRFKVHYNTNFGQNVYITGNHPELGKGNIEKAIKMNYMENELENWLCDASFSYIHKGNPIEYRYVVKSSDSFDSNNQIIIESLPRKLNFSSDIQRGFIEISDSFFGNLKYHEFILTKSPFTDVFFKPAIFEDEDFEIINLWENDPKELKIPVQFRVISTNPFDNFQIRLTGSSKKLGNWDPYLSIPVSNKEFPIWKTVVWMEKEDFPFEYKYIVCPRQENISYISEEKFDHEFGGNRKAKLTEKNLDLKSNFKSNIQAIFLDGGNLRSSQNQIKPRIAGISIPVFSIRSKNGLGVGEFNDIELLADWASRAHFRFIQILPINDTRITGTWDDSYPYSALSSIALHPIYINLDSLDLSDEIRTEIENVKKEMNQMVRDPKTNRNIFKYPELDYPEVIKTKMDFLRKIFLINKEKIKESKEIAKFIRENSSWLPAYSVLCALADKNGISDFNLWDKFRQVTQEEINFLMTAKSDIFDGVMFYVWIQFELDKQLSTAVKTANRLGIVLMGDLPIGVDLRSADVWTQPSLFNLDCNAGAPPDYFSKKGQNWFFPTYNWMEMERSNYKYWINRLTCLEKYFQALRVDHIIGWFRIWEIPNYYKQGLMGHFNPSIPIYRQELINLGIQNFQRLCQPYLSFHVLEHYLEKDQLEKIHDFLEKDQFGNFQFKPDFDTQSKIYEKVEDQKMKEVLFALISEVCLLGNPDSDVFYPRYDLQKTLSFQDLDFNIQKVLLKLSNEYFYSKQESLWKQTARKRLPLLTQKTKMLIIAEDLGFKPQCLDPILKEMQIPGMKIERMSSNTSESPFDNPKKFDYMSMTSTSTHDSENIREWWEITDNRKYYWNKILHNFGDPPKIADIQVCTQIIKQNLESDSMICIIPIQDWFSINPDLRIENPKDERINYPPDRNHHWKYQIQIPVEDLINEYPSFTNKISRMIDSSDRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGA5</accession>
    <name>A0A9Q0RGA5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGA5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="42981" checksum="91DC448DCA5F3022" modified="2023-09-13" version="1">MPRKQSKNKKRKESIKEKKIESESESEYKSESISETESETETETETETESTSTSISETESESESTSTSKSTSTSKSTSKSTSTSETESTSESEDESLEQKTKRRRKTRKKQIRKKQTRKKQTRKKQIRKKQTRKKQTRKKQTRKLKKLSTPKPKLSFLKEHLLDDLNSTEQKNYISKKTFQKLIEIIGNEYIEFLEWKEEATSKIQKITEAYLRWFIQGCFSCAHHAERKEVEEEDIQLVKKIRNHVGQDFFIDTPVMKDRRFFASQLPPRDLFSENSNSFLNRKNEFLDCLNQISQKELRNIISSVDSPHFPSRLFQDLKDELAAFVDNFIILILAYVAHQNTFAVSYSHVILGLRSLMKDSKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGD9</accession>
    <name>A0A9Q0RGD9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000043">
        <property type="protein sequence ID" value="KAJ5079029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1557"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="232"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="795"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1606" mass="181428" checksum="82B810A826B7B252" modified="2023-09-13" version="1">MFIENENQNPKRKLYSCGYYRYNGLGKDEEDNYEFTEIKSFLFENDDNILDFSVGSYHTLILTSNSKLIGFGYNEYGQLGTGDTKWQLIPIQIELPKLRFNEEISNYHIYCGYHKSFLYYSPPSFSNLEEDLIKLFERKEFCDISFKTENGEIIKAHKLILKYRLNQNGNEIEKLQEIISKKSIKESNQIFEMIYSNKIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVINDTSNKVTDYSELSNKSFEIFEYWIYSNQIKDEIQITQEIIDEIEINFYSFFFNFNLNDQIKLNSKNNFLIQFLLIFLIIFKFSFQNQKSISSLISISPILTEIETTRLLTETTRYYSTPDEAWIWNLLDQFSASGNFGSSISIYEDVLVIGAYGENKAYIYRYNGTNFELEQILSETSSYFGSSVSIYEDVIVIGDYSANKAYIYRYNGTNFEQEQILSEPSASSFGYSISIYEDVLVIGAYGANKAYIYRYNGTNFEQEQILSEIAQYFGSSVSIYEDVIVIGTYDARQVYIYRYNGTNFEQEQILSEPSASNFGKSVSIYENATVIGAHGANKAYIYRYNGTNFEQEQILSEPSASNFGKSVSIYEDVIVIGAYDVNKAYIYRYNGTNFEQEQILSGIASTFGYSVSIYGNFTAIGAYMTSQAFVYEASLIPQVNILNCSSLFSSFDCYWNKVEFISTLSYQINYGFDWIDIDSPILEDGNVYYQQFNSSFYDNITGNEYYSIQIKACADSTPKCGEPSSFINLTTKIDSVKDFQLTNANSSINVTWNPPNVQINEGIAHLDHYNISYFNQSQPDSISFFSVDNSSLDYFLNNLESENDYNISIWGCRTQECEGDDKGEIVESSISLLFSEVSDLSCSISSSIDINCNWNQPINCSIPSYYNLTYQAISEEDSGNYQPTSSNQQFTAQFPNQEYQINVSACNSNGKCGNISTTSIITDNLPIAPTIYETISKIEEIELNFTKLTNANNYSISLDNGTNWQKFTSLDLNGNEVIGTINGISGNIEYNISIRGCADLNCETQYLGLSSSIITKKAKLGNITSLNCNSLICGFECTWDLLNLSDGLEGYSLSYNSTSVCLPKTQTNYSISGELIPLGNYEISIYSSADLNCSFNEYSGINSTTSIITDNLPAPTIYEAISKIEEIELNFTKVEYANNYSISLDNGTNWQNFTSLDLNGNEVIGTINGISGNIEYNISIRGCVDSICETQYLGLSSSIITKKAKLGNITSLNCSSIPFGFECTWDLLNLSDGLEGYSLSYNSTSVCLPKTQTNYSISLLLPYQYYEISIYSSADLNCSFNEYSGINSTTSIITDNLPAPTIYEAISKIEEIELNFTKVEYANNYSISLDNGTNWQNFTSLDLNGNEVIGTISGISGNVEYNISIRGCADLNCETQYLGLSSSIITKKAKLGNITSLNCNSLINGFICTWDLLNLSDGLQKYSFHYNMFSVCLPKFTNFYSVSGLNGGEEYTILIFASTDENCIGDEYSGIISSASVKILSPTETSESSSKAPIIAMTVVIPVLVITTVIIIVVLIKKQKNSIQNFIKQEQKKLEEAGEIEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGM2</accession>
    <name>A0A9Q0RGM2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGM2"/>
    <dbReference type="OrthoDB" id="3036502at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="789"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1034" mass="119988" checksum="D8200BBD2DC38C0F" modified="2023-09-13" version="1">MSRKTEDKEKQLQTAVIESNTKKMKNLLSGGFIKKKVNPNFVTENGETLLHVAVKANSNEKMINLLLTDYNADVNFKDHENQTPLIYAAKNTNLSIETIQLLKEKGADLKHKNNSNEDITIIFLKKSKLNLFSGYIDNYEEHKKETLSTIIDSENQNTMLHQMVYEDNIDGIELFCKNGADLEAKNKDGLTPFWLSVSLDKLDCFQKLYQLNKDLEIDENGNSIIHKISLFKSINIMKNLQKDGLTEKYIEHKNKDKQQTPLNYFCTNTNNDDPEMLRLLHEVGGKFDTVDINGNTPFLNICKRKLPKCLEYFLSELRNDSRAFNFEQKNEDGDNCLHLLTKNFYSDGLLSVLKSGIIIENILNQQNNQNQTPWFLAKTYETIDLKERQNSIDVLEKFGAKKDIFPNSFDLSKIQEIEENLIKNAELKKQKIEDEKQKKVDDNLKENENENENIKTSEKTSEKSDEKSPKEIKEDTQKEPIKEQEKEDSTKAKSKKKDKNELRKEREMKKKMEREKKLLDRQKQKEEKLKQKEKKLLDKQKQKEEKLKQKEEKMKTKQLGAIPRGNSMGKLEDRPKSISSIKTELKKETPKTPRKTETKDEKKETPIKPLSPKMPDQKPIPKKGILQKTQSEMVESQDSQNNLVKAKSFAYKKDEEQKSKEEKSKEEKSKEEKSKEEKSKEKKSKEKKSKDKKSKEKDDVDDVFGNLDTSSEISSSEKSQQVQEDKSDNDDKDENKDKKDEKDKKDKKDEKDKNQNDNQNDNQMNTNQPENKIENVSEIDPAFEDNSFRLKVSVKKIKKIRGGDSYVKVVSNDLSDQTKIFEAKPKQSPSWEDEEFIFVIGDSIEKMKSIGKITFQLFSFDLFEDELVGELSVDPTTLGLSVNNPKTKSFNLTPKKDPKIKPTLDAVFHIYQGKVFPTQTLISDGNSYLVTENIEEPTNLVSFFQETGKLYAFQNKNFFHPIAFDLSNVLGIERDDIQKESFEKDNFALLFTWKQGYEGLKLFELYSTLKAKTELWEQKIIKFIQFASVNTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGZ1</accession>
    <name>A0A9Q0RGZ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="PVMNAAW"/>
    <dbReference type="OrthoDB" id="5946739at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="50"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="46"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
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        </location>
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    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="311"/>
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            <begin position="345"/>
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            <begin position="413"/>
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    <feature type="repeat" description="ANK" evidence="3">
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            <end position="516"/>
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            <begin position="554"/>
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            <begin position="695"/>
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    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="868"/>
            <end position="901"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="902"/>
            <end position="938"/>
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    <feature type="repeat" description="ANK" evidence="3">
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="1592"/>
            <end position="1627"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1628"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="1665"/>
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        </location>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1702"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1739"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="1990"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1918"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1918"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1932"/>
            <end position="1945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5079258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2102" mass="241979" checksum="839ECB9D4D2D6235" modified="2023-09-13" version="1">MNQNNIWEIIKENNIEKLKEIKNISENELIKENKPILHFAIEKQVSKEIIEELISKGANPKLTDELGRNSLHISIINNPSLEIIELLISKGIDINSKTNDNEETVLHYACRYNSSIEIIQYLISKGIDINSKTNGNETVLHYACRYNSSFEIIKYLISKGIDINSKTKDNETALHYACRYNSSLEIIQHLISKGIDIHSKTIYNQTVLHYACQNENPNLLEIIKYLISKGIDINSKTKLNSVTALHIACMHNSSLEIIEYLISKGIDINSKTNKNATTLHYACFNKNPNSSLEIIQYLISKEIDINSKTIYNETALHLICRYNSSVEIIKYLISKGIDINSKTNENETVLHYACRYNSSLEIIRYLISKGIDIHSKTKDNQNVLHYACKYNSSLEIIQYLISKGIDINSKTNDNQNVLHYACRYNSSFEIIKYLVEKGININSKTNDNETALHYACKYNSSLEIIEYLIEKGININSKTKESVANALHYACLNNNPSLEIIQYLVSKGIDIHEKAKEKISNIHIACHNQSSNPSLEIIQYLISKGIDINSKTIYNENVLHIACRYNSSLKIIQYLVSKGININSKTIYNQTALHYACLNKNPNSSLEIIQYLISKGININSKTIYNENVLHYACRYNSSFEIIKYLISKGININSKTKDNKTALHYACQNKNPNSLEIIKYLISKGIDINSKTNDNETSLHLICRYNSSVEIIKYLISKGIDINSKTNDNETSLHLICRYNSSLEIIKYLISKGIDINSKTNKNETVLHFACEYNSSLEIIQYLISKGIGINSKTIYNQTVLHYACRYNSSLEIIQYLVSKGIDINSKTIYNQTALHYACQNENPNLSFEIIEYLISKGIDINSKTNDNATVLHLVCRYNSSFEIIKYLVEKGIDINSKTNNNETALHLICKNEKMKKLFEIIKYLISKGIDINAKTNDNETALHYVCRYNSSFEIIKYLISKGIDINSKTNKNKTALHLICRYNSSLEIIQYLISKGIDINSKTNDNETALHLICRYNSSLKIIQYLISKGIDINAKTNNNETSLHYSCRYNSSLEIIKYLVSKGIDINSKTNNNQTALHLICRYNSSLKIIQYLIEKGIDINAKANDNETVLHLVCRYNSSFEIIKYLVEKGIDINSKTNNNETALHLICKNEKMKKLFEIIKYLISKGIDINAKTNDNETALHYVCRYNSSLEIIKYLISKGIDINAKTNNNETSLHYSCRYNLSLEIIKYLISKGIDINSKTNNNETALHLICKNEKMKKLYEIIKYLIEKGIDINSKTNNNETALHLVCKKKNSKLYEIIKYLISKGIDINAQTNKKETALHIICENKNKNKNSYEIIKLLIENGIDINAKGDFRKTPLHIVCGKQNQNTNSFEIIKLLIENGIDVNAKTFAGSTALYSAFENRNPSLEIIKYLIEKGIDINAKANDHILHVACKNKNPNSLEIIQYLISKGIDINIKAYNHQETALHSICKSENSNSLKIAQYLISKGIDINAQTKFQKETALHFACQNKNKKSLEKQLYILLAENKNKKSLEIIQHLISKGIDINSKTNNNETALHYACRSFKESLEIIKYLVEKGININSKTKDNKTALHYACQNKNPNSLEIIKYLISKGIDINSKTKDNQTALHYACQNEYLNSSFEIIKYLVEKGIDINAKTNKNKTALHFACQNENPNLSLEIIQYLISKGIDINAKTNDNQTALHYACQNEYLNSSLEIIKYLVEKGIDINSKTNKNKTALHFACQNENPNLSLEIIQYLISKGIDINSKTNYNQTALSILIDEKRKDLIEFMIMNDANIFDLKQNQITNELIELFLKIYSINQDMNQLLNSNDNFSDLNMLKILLISFILDFLILNQIYQNLIQNQNQNQIQNQNQNEIQNEIQNQNQIQIKNKYEYKHEREYVFRNRLKMKKKKKKMKKKKKKMKNLNENQNQNQNQNLNLNENENEVEEFFKEIGFDSNWINSKKGRKGIIKDLSKLYQENETKDFKIIIEKKEIKVHKLILILRSELFKGMFLLNVQDSSNQVHDYSQKSFSTIHQLIYFLYHDKFEEEEKETKEITNQIIEEFDDLKDYYQLNENSIIDLLLKKISKLKLKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHS2</accession>
    <name>A0A9Q0RHS2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-protein ligase e3a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000042">
        <property type="protein sequence ID" value="KAJ5079049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHS2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="264"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="590" mass="68571" checksum="48DC4A937C09BF1C" modified="2023-09-13" version="1">MNEIIFFGENNLGLDFQNKQKKIKKPIQFKFENENENEKQIKQIESSFYSTIFLFKNGKAIEYSRDSKQNPVKIQIEENIQKVTVGYSNEAILTIEGNVFAKGTEINPEKSNEFINISSLIEDINDRIIQDIVSGGYSIYLLTSNQNAYGIGSNYFGQLGFDSKALDETHKPILMMKNVSKIFSGNTSYSFFLLNSNQELFGCGDNQYGQVGLGELRKEEIKIQKLTKIQNIPKGKIIDIQTGNYHSIMMIENENENENQNPKRKLYSCGSSGYNGLGKIYEDTYQFTEIKSSLFENDDILKISVGNTHTLILTSNSKFIVFGGNLFGQLGTGDTKDQLIPIQIEFPKLRFNENISNYHISCGYWNNSLLYYSHSSFSNLEEDLIKLFERKEFCDISFKTKTGEIIKAHKLILKYRLNENENEIEKLEEIISTKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLDENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLLDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHZ6</accession>
    <name>A0A9Q0RHZ6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_03808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHZ6"/>
    <dbReference type="OMA" id="INDDISW"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003976">
        <property type="term" value="F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016256">
        <property type="term" value="P:N-glycan processing to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="8">
        <location>
            <begin position="259"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="8">
        <location>
            <begin position="319"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="793"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5080323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="871" mass="102989" checksum="4996A593183ACF36" modified="2023-09-13" version="1">MLNRRDRIRNKLKKAIDNEQDIQTIKTIQPEDKYEPKKFNNFLVNFVSKPSGICLFVIFGFIAFNILFFIGSQTVRIIIMKKKVQREFCDNISNTCFENLKFEKIDLVYTWVNGSDPKHKELLYETKMKILGKNGDNSTDPPPFPKEVISTNRFQDNQELRYSLRSAQMNAPWIHHIYIVTNGQIPNWLDLSNPKITVIPHEKIFRNLSHLPTFSSPAIESNIHTIPNLSEKFIYCNDDFFFFSKVWPDDFFTSLGQKVSLAWPIPDLPFGCLQNWIGDGFCDIACNFSEYNWDGGDCLHNNSNTSSTPSSPSRYTPRTPINFDYCTKGCLNSWMSDNFCDRACDNYECAYDGGDCNIENKKSFYVTKKFPSMYINITSLFKRGKALKVTFSNSELIRTATNSQKHKTIFLTFFNKNITETVEFKIIGDILDKHMEKKFNITFLKDESMNESDISNEKENFWIGKLIENEKTNQKEMDKIDFGNSSMEINLTPYDENEYQLTDKYSRLIPDQELKEINEAEENIKENDVSFSTQRKLLDTFIESLRFVNDLYNKEYKVEERRVPAHVPHLIDKKVMIRLQNHWSEQFDLTSSRQFRSPKNMQYQFSYYYYLIHEPLEFNMTEFFNNFLDRNQNGVLEENELRILAAFLSDKVSDLFWKQFKMLFNRGDDNDLLCNYMKIIGYPESRSNQTSSYYSQYSQRVELKIIPINQNQNQSENQNQNQNQNQNQNQNQNQNQNENQNQNENENLNQNENQNQNQIENQNQNQNQNQNQNINQNQNINQNQNINKNQNINQNQNQNQNQNQNQNQNQNQNINQNQNQNQNQNQNQNQNQNQNQNQNQNQNENLNQNENQNQNQIENQNQNQNQNKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5D7</accession>
    <name>A0A9Q0L5D7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-threonine 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5D7"/>
    <dbReference type="OMA" id="HWHASPR"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051225">
        <property type="entry name" value="NAD(P)_epim/dehydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42687:SF1">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="303" mass="34171" checksum="2AE095BC36DE5F08" modified="2023-09-13" version="1">MSIKPAQTQKRILVTGSLGQIGTELVSRLRKAYGPENVIASDIKKPSKNHFSIDGPFEYGDVTNIDTLAQLIVKHNIDTVFHLATVLSALGEKMPDVALKVNATGIQNVLELSKSHKFQVIAPSTIAAFGPQTPKEQTPDITVQRPTTIYGVTKVYTELLGEYYQKRFGVDFRSLRLPGIISSEALPGGGTTDYAIEIFYEALTKGQYTYLSEVPENRLSQRTYNITAMSFTPKELADSIRKVKMPRFSISYNPDFRQKIADTWPKSIDDSIARRDWKWRPDYALDEMVKDMFEKLEPKVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L612</accession>
    <name>A0A9Q0L612_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L612"/>
    <dbReference type="OMA" id="CAYKSHA"/>
    <dbReference type="OrthoDB" id="298084at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="143"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="321" mass="38252" checksum="B66C294DA86097D7" modified="2023-09-13" version="1">MKKKRLFHSFSLFDKDSISKQDFDKLKQFDFFLPNSFLIHFERTIFEIQDQTKIKEKEKKIKRRDKRIKSFESEIRNLKSENKKKEKEIEEKWKKEIENKEKENQQMKIEIEDKWKKEVEDLKSKFELMEFQKNFLQFSDSEIIKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDEKGKTLVIIKTKDNFIFGGFTQVGFKYAQNGEFSNDSNAFIFSLRNDKGDRIPAKFTIKQGEEQNAIYSSSSYGPFFGKGYDFCFYSDLQPGYSNFGYSYNPPNGITYNTDSGKSYLAGSYKSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6B8</accession>
    <name>A0A9Q0L6B8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_13481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000140">
        <property type="protein sequence ID" value="KAJ5066544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6B8"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="543"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5066544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="779" mass="90237" checksum="76E0865F2D980EC2" modified="2023-09-13" version="1">MEIIGVALYDYITKQEDALCFFENDIIHNIQPEKTGWWFGEKEGKIGGFPMNYVRLIDKDHPLLSPLEAAQKIIRDVLQTLNLNITTNISLTKKKLRVAITSGGKKRNMLYSKVQQETQSVISLCKERGKLTHLISKGIEEEIIEFARNFNKENYFKQHSLVQVSETDEINEYSFDNIADPNKELPDPLEQELDGMDGDEIDDETASPDGSEDEQSLGETSGKINSIDAFSSERSLIQTEKSQENLPNIDEIEHIPAPLTSYDSFLPPLSGLDDIPVPLTSFDSIPPPVTDFDNIPPPIKNQNQNQNENQNQIEDQNQNQNENQNENKIKIKIKNKIKNQNQNQNQNQNQNQNQNQNQNQIENLDQETSKYLIDTSEWLLKKLDGIISTEKKNVDGLIALNKVQKKKVLLQQAEVLISQANQLIYNLEILRKVCLRDLLKLSKIYHPKLQYGYAIQSFKSQTQPNFHFNSGDFVVLLDITMKKGKTEKFMAEVNKIREEVQPDMIEFVEMKNFDKAFIEKQKPKKHIPKLPKQMKYVSIIDFDPDEIAKQLTKLEYKLFCNIKAAEFLNGNWKKKSTQNFTPNLTEFFGHFNIIESWVATLIIQTEKRKERHKMLSHFVNIATTAKDVNNFTLLRALIKGIFHQEVRNLKKTMTTFSSSSMSKLTELEKMFFRRNNFEEYRKIEEQTADSFLPLIPFLDPHLDEIDAAETRLKKKETEKGELSQELYLALFNIVKFQARSLRIKSSQEMQKYFSKLPVLTDEKLKALSELRALDEINRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6L0</accession>
    <name>A0A9Q0L6L0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6L0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="155" mass="18383" checksum="D9F08F0FBB33FBA6" modified="2023-09-13" version="1">MDNNNNNQIQNANQNQNQNEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6M9</accession>
    <name>A0A9Q0L6M9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6M9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="218"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="46255" checksum="75E804C7EEE7DCE5" modified="2023-09-13" version="1">MDNNNNNNQIENANQNQNENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILNSISKQDFDKLKQFDFFPNSFLVDIQNKVIQDNQKEIENKEKEIEDKNKEIENKEKEIEEKWKKEIEEKWKKEVENKEKEIENKNKEIEDKWKKEVEELKSKFELMELQKIFSDSEIIKEIEYAKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKDNFIFGGFTKVGFNGNTRNINDSNAFIFSLRNDKGDRIPAKFTCKEPQYAIYSGLSNGPMFGDYYGADFGINSNLQTGWSNFGYSYNLPNGITYDTNEAKSYLAGSYDKWVVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8E2</accession>
    <name>A0A9Q0L8E2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_12398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8E2"/>
    <dbReference type="OMA" id="GMNICES"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="534" mass="61737" checksum="2D043489F296B385" modified="2023-09-13" version="1">MSYSKRITSRKSKYKQKIDFEQARDKRFSYAQQLSKNKKENQLLKRRNLNLNENEDEKLNEQFSFSLNQEVDSESIKKKFQEIFNQFENSHENKYSLLVEIRALLSWNFYLPIDEFISSGGLPIILYFLQENDPQFQLEAAWCITNITSGTHEQTEKIVEIGVIPILCNIIKNSESEFVLDQCIWAIGNIASDHIKYRNEIIEADIISSIIKIITTLENLKTIRNCTWSLSILLRDLPIPAFEYVKPLFPILSKLLYINSEEIVHDVLWAFSYLSRGDEKYQQEIIGMNICESLINYFTHKNQSLHIPSLKIIANLLSGNDKISEYVIEKKAIPALVKMLTSSYEIERNNACWAISNICAGTESQQNEVIQNGAIPILVAIMKTDEFKTKKEAAWAISYLAYYRNILGVKDFLKNNGASPYVDLLDSNDPVLIQIILEGISKMLSIGDFITDSSINEIAFLFEEANLVQKLENLLNHQNSKISQLANDIFFQFFSEELINQEDSIIENQNQNQNQNQNQNQNQNQNQNQNQFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8J8</accession>
    <name>A0A9Q0L8J8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase traip</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8J8"/>
    <dbReference type="OMA" id="CKWQMAL"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="538" mass="63908" checksum="0E88A4D3D14C1A41" modified="2023-09-13" version="1">MSKNFEKFQKNQEKKNKEETNLNEEKENHKENENENEKEKKVSNMKTKIQNFKEKNKQLEEKEIALKDRLESVLKDCKILRKQNSESQEENEKLNEEIDNLKIQLENETHYFEQIQKKLDKNASQMKELKKQLTILEQYQHNLNISYSDYDRLKKENEKKNAIIDTLKCNIEEQNEELGKVIQNKETEIIQKQEEIQQLNTQLQSSKKELFSLQTTFAQTTKELEKIFSQLETASKVIENLTKSNDIFKKKIVHLEKQLHLINIVKSKMNQELIEKENISKQLRERINSLEGFLKNKSHQNTILLEKNDHLEKVIISLKKIIEQKDQEIEEYNTKIMFLSKNSNQNSFKNSNQNPIKNPIKNPNQNPIKNQKISPNFLKRKSPLNAEEFQEIIKNKNQKINLLTDSNSKLNQDLQKKDQNIRSINEKLDKIKNENSKFTNQINQLKEKNRDLIQRKQIQTQNQKEIISKLTEKLKLIENGILKENQNLINSELNEIRILLNRITPKTPTKQETNINPNPKSKSKSKSKYKEELIFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8K4</accession>
    <name>A0A9Q0L8K4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8K4"/>
    <dbReference type="OrthoDB" id="756206at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000205">
        <property type="entry name" value="2'-5'-oligoadenylate synthase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="151" mass="17463" checksum="EBBCB923BC78ADA9" modified="2023-09-13" version="1">MKIYVQTSTGKIFPYDINEYDSILKLKQLIESTQGIPVANQKLTYQGSDLRNDQNIKECNIMQETTINLVFTSGENDSTITYQSTTYQTNPTYQTNPTYQSNPTYQSTTYQSNPNYQTTTTTSYQNTPDYQTQTYQTQTYQVQPKMKCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8W9</accession>
    <name>A0A9Q0L8W9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-alpha-acetyltransferase 60</fullName>
            <ecNumber evidence="7">2.3.1.259</ecNumber>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_12480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50604"/>
            <dbReference type="Rhea" id="RHEA-COMP:12745"/>
            <dbReference type="Rhea" id="RHEA-COMP:12746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="ChEBI" id="CHEBI:133414"/>
            <dbReference type="EC" id="2.3.1.259"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetyltransferase family. NAA60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.259" evidence="7"/>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000118">
        <property type="protein sequence ID" value="KAJ5068253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8W9"/>
    <dbReference type="OMA" id="MIYEISC"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5068253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="187" mass="21951" checksum="B57F208CC2AE288B" modified="2023-09-13" version="1">MNSNYNSNFKKTLFPYEYPDSHYQKLFEEGFYSQIALDPNSTKVIGEITAKIEPNFSGCLTKPHQSAYILTFGVAEEMRRKGIGTELFQRLLSEIRQHEKIEEVTLHVNCQNESAIGLYRKLGFSIDTKIHNYYQYHGKYHDAYWMIYEISCGEKEKKEKNKKSFSGFCQNVKMCCGSIYNTYKLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9B9</accession>
    <name>A0A9Q0L9B9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of g-protein signaling 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000128">
        <property type="protein sequence ID" value="KAJ5067433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9B9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="1">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="98" mass="11488" checksum="6BA5D05368BAFF4B" modified="2023-09-13" version="1">MFIIINNFVYSQNTINIPQEIQQNILSQLNQMGENPVATLFYEALKIVHSSLISDKILHYRFLRSLHYKELLSEINEYKGLSSQNKNNNNNNNNNVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9R2</accession>
    <name>A0A9Q0L9R2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9R2"/>
    <dbReference type="OrthoDB" id="7628309at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="235"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="333" mass="39017" checksum="5EE92B813E141C1C" modified="2023-09-13" version="1">MSGFDFNQAMGDQILKNAIEENNLELVKKLYQENPKLNLKFRGDTAVHFSCWFHKRVNIIKLLIEAGGDINYKDDYTPVHYATIGNSSEEIYFLLVDYNGDFTIPDKKTPLDYVKDEKLKQKILNRIQTRKSINQDFLVLFERKEFTDSKLQLQDGEISFHKLIVKSRIGEKYDSLMDILQNKKKNEVEDFLKFIYSSIFENSEVINDILNQIGIQNQELNVVNYENLYQEEESKDFKILFEDGVVLAHKIILIARSDLFRGLFLSVVDESNQVHDYSGISKDAFNVLIKFLYTEKLDSNIPQNILQDLQEKIDYFQLNENSSLDEKIKEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9V4</accession>
    <name>A0A9Q0L9V4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5068992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9V4"/>
    <dbReference type="OMA" id="YRYKMEK"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="4">
        <location>
            <begin position="208"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="382" mass="44844" checksum="B56EC72E02EB3AED" modified="2023-09-13" version="1">MDNRINIRRDINDPSYRYKMDPVETIQKGRGGNTKTIITNIKDISESLETKPEYMTQFFSTELASRAWWNEEQKQTVIKGVFEESQIQDLIFKFIEKYILCPVCKLPELDLVVGTNDIEFKCRASGCVSRKNKSDRLISFIIKSSQLQKAQENANKKKNKKKQKQQQKKKEENENQNQNQNQNENQNENQNDSNLNMNFPDVKVNENDWSLDTSNEAQQKRLQGKICCWKNFASFCYLILQTLQLQRKLKDVSEKLSWNQTTRTLFVCELLFGKNMLEEIPQRKEVLSLLIKTKRAKLAVLGFIERLCGEDYPDLIEFVPHLVKAFYDQDLIEEEFILEWANQKSSKFSKQPTFDLVIEKAKPFVEWLKTAESESSEKEDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA62</accession>
    <name>A0A9Q0LA62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tenascin-r</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA62"/>
    <dbReference type="OrthoDB" id="5985842at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="271" mass="30559" checksum="F890210DD3517B99" modified="2023-09-13" version="1">MKCGESSSLVNLSTKIDSVKNFQLSSPTNYSINVTWNYPNVHINEGIAHLDHYNLSYFNQSQPDLISFVSVDNSSLDYLLNNLESENDYNISICGCRTQECEEDDKGELVESSISLLFGEVTNLSCSISNSISINCNWNQPINCSIPFYYNFTYQSISQNDSGNYQPTSTNQQFTVQLQNQEYQINISSCNSNGKCGYISSTSITTLSPNQTNYDSNTTAITLGIIIPIIVISIIIIGIILFKKKKRRKQIIQEIIKENEEEKELQDNLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAA1</accession>
    <name>A0A9Q0LAA1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1650"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2195" mass="259006" checksum="2B871FB712B91014" modified="2023-09-13" version="1">MSIQQKIQEIASKFNETDLNIIKEGICELYFEIQEQDFLEKFINLSPKSVEIFKIWKICHKNRGNLQTPIIELFKLIENILLNQFVNQKVKINIINTILKNKMKLFYHIFSTNQISQFKIALKLLLVMLENSNAIAQEILPLFSYSIKRYNKSFNLKSKQKKAEFENKLEKADIKRRRITKKKIQVIIENTLIYDDIEKEMENSLKSFFINLFVSFINSEDLFVIKELLGSQEIFYSILEDFQYQSASAIKSILVSLKNNVLLNSAISKKIKSRCFTSQVLNQFGKLFNHILEYKQEKSSLKPLIVEFLEILCISPTNGISYKPDMPDLCITKSKNDNHYIISDIISDDEPEKVKGPLRNQQILALILTLQPTDYLEQHDLIFSILDACYDLYNPYLTSLKVSFEPRPSLKWISNILFISKLVSRHIPKNIIKIIQFDENHLENQINVYEIKSQTLLDLIFPRSLTKTNLSHGFLHSNRLVQHYTILLITHIFKKIESITEVLYKNIEEENKNAKIEITFPLELLTEQFPDLQTVIAIRKRCADTFEENKIDNFHYFTILRLFSYYIKYMPDSIVGSRFDFTCLISPHFLKFDKYAQIQIIRILTQASSIQEINWFQKSKFQKLTFFGVLIDFLRKNVQQQKYNPRKETSKYTSQLVSKKMYDLLILILKSTNIFAKVGENDENDDKQNQEPIMEMESWIDSLVLSPDLDCIQFFDTLVTKVVQKPYQNIDPILEILEKHDSLSSSFSHLLFIALSLIRESQLQITKKTKKSTQTQTTPSSLNNIVSFISIVIIDFIQKLEQIRAKLLISAIQKFYIQPNLSQNRMIETHPLFNSLLWILDLFQEMQDPKTAKKHISNTPFTNENDLFAKSSPESLLENIKDTQSMLSLCFSLSTPQQSFSPFSYLNFKTQILDVLDLEILLRNFMNQQVIKQKQFIQENTMTSPNHKHQQLQTSQDLSNDAKFKDYFIHRLNSISDSRKYIKISTIILFYLQILSKDQDKILCIKLLEKIITISHLKESRNASKTNDHKRLLKLIFTNKTIIFLFDLEKKSKFTDPIIHLCLSVSLYEEKEENELIQPFIHKIISYNFDPENTELNKKIIGYIQLFQKIIPVSKTLELLNAIRFGNILIKNPEEKMEVIQSLLFPLNHKIEAITQKDFRNLLEIAMDFDQLKNTLNIQISEELIYECLAQSLLRQKNKEDNHDAQLEINLYHYFVSDEYFLFCVKQMNLIRTKIICLLIQHNVRFCEIFIENIGSVDIEKNKNNLIQIIGSMNNHFSLNSQSIGELIQIFTLKTSVSKKIIDIRNPELLVSFPMFYENVLSFLSLLQEYKVMNKFILGFGLKEEKKKHFFVNCVQEYRIIHKFYQTQSQVKILKYIFGTLRILWKKNNEPNELETVLLEELRNFQQKNYEIQNKISQYFCANQYKKFERFAKLVLRKRFAHLQSMQSLANLVFLLSQKPDSEDAIKTCFQLLQSHSKFIETITKEKEGKYLGLGVIELVYAIVKNYSSKIWERKALLEILLNSYTAKRNVKDILLLQIFYEFEKKTDLYLSAINFDWGNQKLEAGKNFGKRNPFSQLNFKSVIKLVSKFPVNQPLRPEKISDYYEIREDQEIKYPDLYDPSFLLQWYYYYLISDPDLEIKYLINAGGLTIPLAALSSHDEGMRKISYQILSFIYDKVSRKKDVPKEDNQNQLENQNQNQNQIQIPRRRFITSYQFSEQLQVRVLLQVLKNSIEKPWQRIPSIITYFLCRAAHILMHPSHHLYLGVNHFLIQKPFINLNDVPMFYELFNSSSIEYKQERIFFLRNVINGLKTFEDFSILKHKYVPEILFSFFASKCADYLTKQFIIDVVERAVQNKYAMIDLIKNFAVLSWINSQINFQMSINLVNKLVKLLLNIFIKIFRSDSSFQTTTSHVEKNHRYLIFESFFSQEEKLMKENEFRILIKFCFEEFVMIGKCLVDFVINTENRSNYSVQRFSSEKFEIFQNAIFLVSEIMCLTPNSELKKHIDCRLVFSQYQMARLIKQFEKFDFILIFGESQKENFIVVEKIFNMIITNEFNIFSFEESAQCFWIVNWCLDKLVEGKLILDSKLRLHNLTLLIQKLTRIMKLVNDINKGFLKENLLRKGFITKVIMIASDIFMIKSEDIEEKTKLIKNLNDFLMILLINQNENENEKQLGLELEEQDILSLELTKKILNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAC6</accession>
    <name>A0A9Q0LAC6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAC6"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="106"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="288" mass="33917" checksum="55B988097884EA99" modified="2023-09-13" version="1">MSESQEMPEDRCLFVGDLSRNVTDTELKNIFSKFGELEKIDIKKDRNTGNNLGYGFVHFKFHKDAKKIKKLFKILEIKVKTEKLKLKFLDSHKMRINWGDDSFRKNSVHVQFDATQGQHITEDILRSAFQKFGEISGINLPKTQGKLKGFGFIHFSNDEDGEAAADQAIQTMNDQEIANVKIKCNFGKRTKKQYPQGHNFSGQNNSANQQYSWNLYYYNMMAQDPNQMSTDPNSDKAMQQYQQQQYQQYQQMQQYQQYQQYQQYQQQLAAMYFQNNHLDPNNQKKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAX9</accession>
    <name>A0A9Q0LAX9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAX9"/>
    <dbReference type="OMA" id="HEVLHYD"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="295"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="471" mass="55127" checksum="F4765736BABD3BF6" modified="2023-09-13" version="1">MEAYSNLEKLSNDLKQLFQNQNEENYSNFEIICEQNQISFKTHKSILSSRSQYFKSLFNSKMKEFQENKLILSDVSSSILSLVLNYFYSGKIEINSENVIEILMFSSKYLIDELIEICSKFIKNNLQTETVIDVLKLSESMNFNQLLDFSYQFISENFDEFIKTSFFFELEENHLNSILSNDEIIVNEFEIFQSIINWGKHKSSIKSKIKKKNKQEKEKLQNQISSVIDKIRFIDFSKQEVKKVLKEDLIPKQISQKLTELKKLQKSSKNEAKLKEFIEKENSLIFKSRIGFKSAIIKEKKYMNALREWLNDDKFFLKMKLGFSAKRDAFDSKKWHEKVDDRGKTLIVIKTTNNCIFGGYSKVGWLSGKNLTYIADPDSFLFSLKNLTQNLPQKFPIQDKKKSNALYYDSSDGPVFDDMRIYSTFKTGRSIFFGVSFTLPNGMKDSTKEAMNYFAGGDGYWNIEDIETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB83</accession>
    <name>A0A9Q0LB83_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_02098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="835"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1566" mass="182462" checksum="9AB0B6065FAE3CCD" modified="2023-09-13" version="1">MINSSKELMLMIFNLSNHQFSPEKLVQTFNKLKLNENLDENLNINEVLIQDEFLRSSFVNSVIKNMKQNSNSSIFILESLHFFNIKKIDLLFLHFSKFDQVKIIFDLLEIHLENLKIQIQCWKFLRNLYRISKKDQNKWKLLERIRDSSNKKIIFSSLEKYWEKKTLAFLILHFCYHLVKLEFSSFFREHFFNLIVSVFVKHKENEEVEVLCLKFITRLLLFSRKKKENEEKEKEKEKEKETRKAKNLRLKNNLIKQILPHILGLMTKYSHSLLFIETANYSLSIIFQDFEESESVSKIEVLNSIFGTFLTFPGNGKIQEKALFAINSVVSDPSCKNHYDFQENEGIKCVQICLKKFRRDENIQIAICNVLSSLAINKKTQLPNEIQGQLEFALPKTIKTMRLFPNNPRVQGLCCRTLRNLVVNDGARFENIAKRGGIGLIKTAIQKNYRDLQLLDPAFDCLSYLAENPTCCEQIVKFGFADIINCVLDWQKMQKRLQRQMNKQIQIQMQIQVQKKKQAEEVDQEFENIRLLLRMAEIGAEINRIIPHLTTHAFESKEVLRLMISFEHLALFLLPSCPEIRQRLLSNQNLANVMKVLKCFNENINVVIVCCGVLTDLAKMKKKDSIQKQIILDAVDIFLRAMRKNPDVKQLHQKCLLFFAISTNQNSDVCSEIVSRKAIPTFISSTFRFYRDSNCAKFGVQTILNLANIQLDSLVEISKLGGPNLIEFIIKTHPNNMYLNNVDKTIWKTIPKPIQSRSDRIAMHEQNSIIQKQRFRVKKSRFVLVEQQWMNFHGSSVVFKNKVLHSIEFWNQGWRVAKRKFPKVHDLPVLDSRVFTRYSGFLIKRGLKFQTWKTRWFVLTDESFSYYKSKNEISCIKEIKLSDIINIKKLDKNNKYHKDYCFEIITKSRILPIQAETEEKMEGWISIITETLEIRRLLQKNLPILNDCLNGNFSSLTETTEINCFIDKNGDSLLHHFIRNRRTDILTEISPVYDAQLKISKKNYLSLSALEIAVSLYLEANRPQENILDAFLVSINDKSIFKDSEISKCLSRFWKFWKNQLTSSLIEKNAKNQNQVINDFVFNSLEENVIFDIQKIIPENAQLSSKTMFNYFISKQNWNLSIFTLHHLKNIKKEDIIESLQYTQEYYSNLIETLITENLWQIYQITFNIFELLLDCQPKSLNLKPSVWAKIFSLIFQSPNYADVLFKLISLGINIDSFQIENSKITPFQFLVSRNEVDIVEKILKEKHVNISSTKFTEDDIPSIMHFVCQEITKNNVVQKSQMVKLLLEYGADCKIVDKQSRSALHHCISGKFGDVLINEEMSENGLDINIPEDRSEIQLEILFDQLESHSLVNQTDSQARTILMSACQHGETEIVSRLIKTKNVQLMDRDLNGWIALHYSIKFAKFEIVKFLLQIDNKDNSQILVQTKNNATVFHLAVMGSIDLDASSEIFTLLYSYYKKNFDKDPDLNQLTDQKKNSVLHLACINGHKNIVSEICKIKDVDLNLQNFKGKTPLMCACESLIPSVEIVKNLILNGVSKTLKCKEEKTAYDYAIQSGNTLFLGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBD6</accession>
    <name>A0A9Q0LBD6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBD6"/>
    <dbReference type="OrthoDB" id="10691883at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="3">
        <location>
            <begin position="615"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="89729" checksum="3BAE01DA52241EA7" modified="2023-09-13" version="1">MSKSGPLHKITSHITRKRFFELKEGFLSYRSLSKRKNNDIMGAIYLYNFTITRADKQTSKKYSIELKPFPRKILQLPYLIFGNSELEIQSWLLALQESKSEINSKIALIKELTQNTLYLYETDSCKVLLSSINLTKDVVIRPGYHKDKIIKQVSHSFMIEMEHDKKYINYIFRAESIKSCRSWIESLINSQAFAEIQENKKNQIEKLNEIQKEKSNENLNENENQIQKENLNQNENQNLSENSNEKSNEKSNEKSSNSIKENNHEIQNQNIHENESESIPESFSQKFSISDSGSDIEESFDDPSLLATSETDSSNENKSESKRRSSDSSQIEDPSNEPLRNQETKLKNFYILSQQSQEPKIIANENQNKTKRRFFGSKKPKKQKQPKTKGKAKNFNSLKISRKINKKKERRRKQNNKDIIPSFFDHHYQIAKEIKSVQQMINSLINTQNNLNQNENENQIENENENQNENQNENQNENQNENQNENQIENQIENKNENKIENKIENKIENKIEKNEEFELFLKYYESCHLIFDQNNKSINQSLSCLDGFEEDNISQQKIESENLNFEEEQFINSQIEKSLNEFLSRIDNLQKKYLMHPETTPKKLVNNRVKFQVDSQDQDAFMIARILSSIMNFRLKKNDGISFKFLDCVHKWNNLLLDVGYYFTQQIKIPGNISSDSINFVKTFIFFIYGLNNSLLYDWIIILTLPKFTKQFFQQNSLVVQKKFAINIRNILSILHDFHFSLELNFEQLVIPYLFEEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBT5</accession>
    <name>A0A9Q0LBT5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBT5"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="565" mass="67507" checksum="29D8C070169D5B99" modified="2023-09-13" version="1">MAIHSIEFISGLKLEPFNYLFSSDLISQVGNSDIKQQKLEKIYWPSMGSHPFYEEFKKEKLYWKFCENEHLNYVKYSDMKLQNWCSFCAKNITETTDPISDKFFENVLSYSVSKFPNQNPAFTLREMNPITFRIIRLLTHLAIISIAIPSNKLSKHFIEIINNCVFKPENQEELIKNLYDHIINDLTILSKLTNLSLYQAMIYYHETLNLITRVSDLSFSKFSPNKNGRQKFEEIFSQIYKNKHIEIIQKIKEKTEDEIETKLQQPKINVDIFNLEPPNLYPIINMFYQNENRKSYPLIQLVLDNTQEFEILNLFEGFLKFSSFIFNILNGKITKEESETIQIKKFITKETKSLYLEFEDFWRLSTKEMKYLQFTKDIQSKNFINEINGEKKVYICLPGESNENLMISALIEHTMNIHNKLAKIFFNKYNDNDNDNDNDNDNDNDKNSHFDLNFPVTVNNFNTKQLIKFDIKEFKHFVSQNIIHDLQIVEDYISQKFRYLKNPILLNLNEIQNFSYWKRKDGLKTQFLQNKQWKQKDILKEEWKEIEKELDENNLKSFLMKLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCB4</accession>
    <name>A0A9Q0LCB4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="9">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCB4"/>
    <dbReference type="OMA" id="PNCYEFG"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5068660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="197" mass="22964" checksum="8ED4DCABA9F74077" modified="2023-09-13" version="1">MSFNFKQIPIALVCARNMNRSMESHSLLKIHGYNIESYGTSSVVKLPSPSGFDSNIYDFNTPYLEIAEDLKKKDFKFYSQSGVLELLERNHLIKSTPQKFQDSKKFFPLIITFEIRVYDEVVKHLEQNSTNSVIPIYVINFETVDTNEEAFISSQLVLKLIQQIENNGSQWEENLEIIIDNFQKETSRKITFNILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCF1</accession>
    <name>A0A9Q0LCF1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCF1"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040151221" evidence="2">
        <location>
            <begin position="27"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="367"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="507" mass="58431" checksum="D7522D778CB4FF63" modified="2023-09-13" version="1">MSLSTSKFYLVIFIILISIFSVRNYGNPIENKLTSTNLKQFMKTHNPTLILITAPNCLECDALEQILSLLSSRVPHVTVAKIDFSEDPQAVKQIGASYPKQIFIYIDGNYREFSVPGNVDYMAEKLSTVEDPKVVLITRDNKLEFFSNNDVKIVGFFKKTNSIQFEALQKVAKLLQFELRFGYFDSMTVAKSVKLKKENTIAIIKPGEPPVFFDQFESIKEKSTSDSLFESLLKFIDKNKQQIVTELTSSNYARHLFNIHTPVLVLFCHEKEIPKQSSFLRKLNQELKKITPIKDNYFLRNPIPFYIHNIDKSQNLAEFFKIDPAVVIYPHLIVTNPSERTIFPFKRKQRHEIALKINEIIEWMFEFYENKLSPQVKSEKEPIKNNGAVRILTANNFPLYVTGSDEEWVVEFMSDSCSHCKSFNPIFSQIASSFYKVNGINFGQFNVMKNDLDPALEVVSLPTVLFFPKDKSQPFQRLTAQRTPENVISFIISNSLLSLDKIEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD02</accession>
    <name>A0A9Q0LD02_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_10682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD02"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="283"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="329"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5070612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="579" mass="66811" checksum="4B3BCDE3BD2A699A" modified="2023-09-13" version="1">MQLISNQYESSEDDDDFLNKNNENENENENEKPKEIKINSKPNLNENLNENLKTNSNENENIKKNVKKRQIEDDLTGFLSNETALVKVPQLAAPVALQTDFKIEKGTKILEHNPTYKEMLEIYKPIETNDPFTSLPEEYKNIASGHIEVLDTVINPVYDQMLFKPKHRKKTKATNRRKGKTKTRAEPFGDPSTDNYKGPWAKPVKLKGKFANRKITEQEKLIYEEQMKKTDEDDDTKKNFKEQVEFHLTRRRDSLQRSWIIPPTDLKQKEHKCWYPKKLAHTWNGHTRGVSKISLFPTTGHLLLSGSFDQSIKIWDVSNKFGRKCIQTYVGHSKGVKDVCFNYNGRHFLSCSYDKKIKLWDTETGQVIQTFSTKKTPLCINFHPSPRENEQFITGCSDKTILQFDAASGKMVQKYDYHLGAVNTVTFIGKSGKFISTSDDKTLRIWDFGISVPVKYISDPEMQSMPSVAVHPSTHYIACQSMDNQVLVYETRKFKLLGKKKFKGHLTSGFACQVNFSPDGQFVISGDTDGKLYIWDWETTKIFKTLKAHDKVLIGCEWHPIEPSKVVTCSWDSNIKYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDN2</accession>
    <name>A0A9Q0LDN2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dedicator of cytokinesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_02178</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="XQYETVV"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="526"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="11">
        <location>
            <begin position="542"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="12">
        <location>
            <begin position="1400"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="414"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5069608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1816" mass="214984" checksum="32EFFC221DBF3BEB" modified="2023-09-13" version="1">MSCWEKTNKFGVALYSFKNKDAKTELPLKIGDPLHIKEESKDWFRVKNILTQRIGIVPKNYVDIINDPPPNKEEYLKLKILPSIKTNPIIIESQNVLIEWKKLLDHICYQEKNFKKFSELKYSILTLMGYRENMLKNKEPNEETIKIQENQIIDSIDRCKRLLNIPVFPRRENGEIADENNIGLINLYQLHSDQIAQNKGITQKIEAQSTGQTDNNQLVLDFQMAILQLPSEMELQFFLFDNDKSEQVSESYSFRIERSGMHADINLHGKLKTIFKDIPNSDLTPNLYLVCRMMRLGVLLIDEKLQKKYSKKKCREYRRPFGCGILQLSETILKYSKGNMKEETINMFLHSSDFNFFKLHKMLISGEQGLKPLPGPGVKISWVLYAGEYEDLLSIKELELNNKLKEMENAEMIPTDIESNIETENEQKIESEKSFDQKTENENQNENQSEKSKSFDQKTENENQSENQSENQNVNEQEKEKEKESETSIQTNSIQIETQNKKELESKNKEEQEYIESLKYFKHIGISQEMKFPEVILPSYIRNDLYITVHSGEFLQDRKRSAKNVEMRIYVRKNNAEKFDDFVENCISFGNANETINFYKTYVYYHKNNPFWEETIRITMPTHLFEETHLYIEAYHCTTNENHDNKLFGFAFLPFFQNGAMIKQGKVTLPTYKYVLKTLKEEPTFYLEENESKQPKQKSKLTQRKEQIELSINLCSTKLTQVTNVVGLLKWKENSDDLSKILKDLTFTPPSEIVKFIREILDTLFQLLEEKGKDEQSRKMIYESIDFVIGIVADKRFKTFIPVVNDYIQTRFSRASNSKDENTSKENEMLTKSLCKVYVFYMDKLKSMLSDIQESNRKTLLNTLRVIEYIFKFIIYSWLLNIHENPIEANNQQKFIGDIKNILVKLQDLMSRTQPVWINAAQDMALRNFKSIFFDLSKVLRQDDLTNSFKSMILSIRMESLKVLNHSKLDWIISLLKQGLFDDPDSRSVIFPLLFEQISFHYKQSEEELKLCIDIVKIIINKAFEDLRLPDSKNSRNFIKDISRLPRKIFELLAHIKYLEEQKIAKVKSKYEKKFQKSQKEDKQQDPKKPTQPKNTQITSIEDTKEYKDKIARVKSKREELKRGLVTSILMLFSTINQRDAQLFFEKYDSRPRVRPRFVDNVFSLFMDLIKNPIYLGDFERFEIIQYKIIMKGFKMFHTLMKNFTGRSFIFKLWNLYLETLICFINLPKLQLEKLSNFEKHKILEFCGGDLRLGVVDLLDNSWKLIGKREYDFISNKTEDFLSFMLLDNEKIKELGLNIYYSMLKCEIEKTQNFKQIEQSTVDTIYHFIREEKDKKFTDYFFKNIEPKFKQDSKLKEKSSNFVEQVHQLMNQITKLKDYPEQEKYEDERTFVLLNLMDYLYRTKRYSMYSRYTHLLSQLHFKNGNFTEAALALTKVIEILEWNEETIEEKMDEGMFNYPRESSSSRKERIILNAIDYFDKGKSWENTISLIDSLQEQYQKNYEYEKLSDLMKRKGEMYSKIVSTERFFANYFRIGYYGNGFNQEIYREFKNKEFIYRGAELEQLSVFMGKIKAKFPEAKIGSDDPNIADKNKNIQYIQISSLTTSSFEEKEGKKKEYDPKMPEKIKRFYQNNGLQVFMYSKPFRKTKEKSDNEFKDLWLRTTYLISEDPFPLFIRRSPVKEKIIVELSPIHNAINSVNEKNDDLEKMITKYEDYDGKNVSPFSMAFNGVIDAAVNGGVFRYQDAFFNPDFLKEDKQHENLVKELKLSLKKQQEILEAGVSLHSRICPDEMRPFHENMEKQFAKMKGLILPSLQDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDT1</accession>
    <name>A0A9Q0LDT1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDT1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044784">
        <property type="entry name" value="At1g01640-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47274:SF11">
        <property type="entry name" value="(RAPE) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47274">
        <property type="entry name" value="BTB/POZ DOMAIN CONTAINING PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="247" mass="29873" checksum="86FCD063C0C3267A" modified="2023-09-13" version="1">MFGNKKTSDFQIYCGKDKILIPCHKSILEARSKYFMINRRENKFNSIYFNNFSSEIVKPIIKFFYNGKFKFDKQKFDKYFKFANQIKLKEIQFKIELEIQSIFNIENILEIYFKSQKINSKNLSQNCEKFIFQNIQFIISNPNFDKYLNQNQNQIYNFIGLISLNQNLPNQFQIIQQIEQKLNQNNQKKLIKLIKFETNQNENENNEIENSFSNLLNQILQTKSINQFQIQKSKINQFLNFKIKLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE77</accession>
    <name>A0A9Q0LE77_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_07021</name>
        <name evidence="14" type="ORF">M0811_10481</name>
        <name evidence="15" type="ORF">M0811_10484</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE77"/>
    <dbReference type="OMA" id="IEWAFAR"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000096">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="99"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5071209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5071212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5076157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="190" mass="21083" checksum="E467AEE4559ACD0F" modified="2023-09-13" version="1">MARTKSTGKKSTSGKRPHRGSKGQKGQKTAQKGQKARKGQKAQKGQKGQKTGQKAQKGQKTAQKARKGQKGQKGHKTAQKGQKGKKSSVAAKRQRRVKPGTVATREIKKYQKSTELLLRKLPFQRLVRDIAHEHKSDLRFQSAAIAALQEATEAFIVEVLEDTNLCALHAKRVTIMKNDLDLVKKIRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE86</accession>
    <name>A0A9Q0LE86_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine rich repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE86"/>
    <dbReference type="OMA" id="FCNDSTE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="290" mass="34451" checksum="F94628E16F63DF31" modified="2023-09-13" version="1">MSNLKKLNLNDTQINFIPKKILETAIKNLSFGGKEYKKLEKQKEDFEKQQKELEKQKKELEKQQKDNKKGNQNQQVGTNQKRRGLDKDNKRRHTGRNSPTKSTSPTKSTSPTSTNQNTGHSDKSNRTYLENIQNNQSQNYHNYQNQDQDQNQNQYANQYGNQNQYGNQYANQYGNQYGNQYQNQNQYANQYGNQYGNQYGNQYQQQYQNQNQNQNQNQNQNQNQNQNQNRKKRERNPTSQELSNFLQIVGFEPKIFEDPSDQEILKMQFEILREEFKMDTKQLPKVEIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFB1</accession>
    <name>A0A9Q0LFB1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein sog2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFB1"/>
    <dbReference type="OMA" id="WRICANE"/>
    <dbReference type="OrthoDB" id="2187496at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="630" mass="72611" checksum="56C40ABEA2DD5CA2" modified="2023-09-13" version="1">MNKNEIFYQQKKDEFENQNKNENQEELKGINNSQDEEKKVFLIDNKNGEISIENGKEKTTEKYEKEDFAQRKSVVLNFESDVASSAIDILFDDLLLSIFSFLDKRSLCKCELVCNKWRICANERFLWSKVNLKEINRKVNDINIACLAKKHPEMRAVKLHNCSLVSDKGIMAISSLCKNIKCFDLGHDNLRIARRSITDNSLKCFSKYSPELEALRMGLCTRITTRGLDTLFRGCTNLKFLDLSRCSLAGIPESISRLVHLESLILDANDLASLEDWVSQLGNLKSLQLRDNQLSQLPKCLKNLSNLTALDLANNIFSSFPDELCGLTSLRRLVLSNNVITQISPLISGLEFLEELRLDHNEISSLPVEICGLSRLRVLRINNNHVVRLPVQIHQLSNLTVLDFSDNSLFELPDSLAHLPNLRYLKLFNNRLTHLPDLLSNLSSLQSLFLSDNLISRFPDSFCDIQSLRCLVVHNNKILELPDNFGRLKNLERLELIGNRLQRFPDSFFKLQKLQTLWLGFNFISFIPEKFSQLISLKELGLNNNNISKIPEKLTSLQNLKTLHIFNNKIPEKEFQPFHKIKNLQTFLFHNNSINSSQREQTNQPPLEMIQNNLLQIIQHTFAKMPKRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGC7</accession>
    <name>A0A9Q0LGC7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGC7"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5072786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="215" mass="25550" checksum="B82B9ED3EBF5DAA5" modified="2023-09-13" version="1">MLIEDENEKRKIYSCGNYELNGFGRSINKFTELKSSFFEHGDVIDFSVGENHTLILISNRTIIGFGNNEWRQLGTKKKYFYQTKPIRIKLHKLTFNISDYHLSCGFQNSFIYYIPSPFSNLEEDLIKIFRRKEFCDISFKTINPNEKIEAHKLILKYRLKDQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKVNPKLYPEIKEIINLNEKLKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGZ0</accession>
    <name>A0A9Q0LGZ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGZ0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF128">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="523"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="640" mass="74608" checksum="16DCB48FD0DCBD71" modified="2023-09-13" version="1">MKNTPNPSLLKLIPKKPFKKFQKFKNLKEVKEFYTLLQSSGFLEKIKPSIYRTSKQKKPILKNTSLHNLCENKNVDIPMIQFLLDNGNSLNEEKEMTPFHVLCMNKSVTVDLLKFCLDNNAILKESYITPFHLLCTNKSVTLPMIKLFPLSILDPKKPIVSPLQYLCENESINIEILEYFVSKGCDFKRVNVSLLYFLARNKSVTFEMLKLLIDNGAEINNNSTTPFHNLCGNPSVTIEMMKLLLENGAEIATQTYTTFHSLCGNPSITIEMMKFLLENGAKMNTQTATPLTILCNNEKITVELLDTFISESLSRNEKCSLGQGLFLESKALNIEIIEYLFEKSPDLIPFDAVDLVYRNSKIKNEENTKIIDYLVDKGYINPSKNDKEKIIENVFEDNLELFRETAESFHEDFLNLFERSEFTDFQISKFKVHRLMIEIRTGKKAEEVREILSKFTEEEVKAILIWIYTGKVEYQKKSTSIFEEKENISKNFFDILTEIGISNPQKRSLKEDIMKLYYDEESKDFVIEVQEKEIKVHKLILQTRSELFRQMFLLVQDDSNRTKDYTGKNFHSMNLLVKFLYSDKLNPEDEDYLIVQTKKDSDPDFDFNFLVDFFQLNPKSKLNYYEERVDPSTILGDFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHT3</accession>
    <name>A0A9Q0LHT3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHT3"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="618" mass="71984" checksum="0F7ED8AF6C089278" modified="2023-09-13" version="1">MNDCLFFGQNENQKLIKNEPERITKPIQFKFENENENENENENEKQIKQISSGRYSTIFLFKNGKAIEYLKENDSNQNPSKTQIENIQKVTVGFANEAILTKEGNVFAKGYDINPKNPKEFINISSLIKDKNDRIIEDIVSGRNSIYLLTSNQNAYGIGSNGYVQLGVDSETLEKTEKPILMMKNISKIFSGNYSNHVFLLNSNQELFGCGNNSYAQLGLGESIKEEINIQKLTKLQNIPKGKIIDIQCGYAHSIMLIENENQNPKRKLYSCGRYFFNGLGKNEDTRIFTEIKSSLFENDDILDFSVGCFQNLILASNGKLIGFGGNFYGELGTGDTKQQKILIQIELPKLRFNEDISNYHISCGASKSFLYYSPPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNQNQNEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDNSNKVTDYSELSNKSFQILEYWIYSNQIKEEIQITQEIIQFDDFNELNEEKFKRIKYSETTKKITQEIINEIEIGIDYFQLNQTNPNLFDLLINKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI27</accession>
    <name>A0A9Q0LI27_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein rcc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI27"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF8">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HERC2-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="216" mass="25298" checksum="F59BEF22521ACB16" modified="2023-09-13" version="1">MKIKNQNQNQNQNPKRKLYSCGYYHYNGLDKIQHTDEFTEIESSLFENDDDNIILDISVGESHTLVLTSNSKLIVFGSNEHGQLGNGNTKYQFIPIQIELPKLRFNENISNYHISCGYSTSFFYYSPSLSSSFSNLEEDLIKLFRRKEFCNISFKTENGEIIKAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNKIINPKVIFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI61</accession>
    <name>A0A9Q0LI61_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rab5 gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI61"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="1">
        <location>
            <begin position="115"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="319" mass="38745" checksum="199D702B6EA66669" modified="2023-09-13" version="1">MNFEDFLKIHRYFDFYNFIKKDKSQTLYQKIRRGIVILLHQRKKEDPRENDNKIIEFIDKITQETVEKHILKWNKQQKREKTIKQKTNEFREYFERYILRKMYTRTFRLNPKEDEEKDKALRAFFRKLSFIKPKHLEIPEDLVKQKGAHKARKKLQEINNAKNPHDKIERICESCNQINKILDRANMNGADSFFPFFIYQVLHANPLNIHSNIEYILRFKNSNLLSMTQAGYYFTNFSSAVRFLENLTAQQVLMSQEEFENHMNQIKSEENEPKYLFENVPLEKLNIRDLRDILLEYKKIALENEELKGILQKKQLKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI76</accession>
    <name>A0A9Q0LI76_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Copine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_08775</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI76"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000042">
        <property type="entry name" value="Copine 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF106">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="122"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="14">
        <location>
            <begin position="797"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="14">
        <location>
            <begin position="860"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="573"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="674"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="697"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="726"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5073367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="902" mass="102934" checksum="912AFE840B1B91D6" modified="2023-09-13" version="1">MDVPVERVELSILCNNLPRSQSAHYFVVLTEESNGQWIELGRTEAKKSSEPRFSRSFVVEYFFEKIQLFQFWLYASQQEQTPQNLQQSRFVGLIELKLSELVGSRSQELTRKIENPKKPNETLGTISIFAEEMEPTTVTEPVITFHFGGRKLAKKDFFGKSDPYLEIYRMKEGGTFVPCTQTEYLKNTLNPTWKPLKISLTRLCNNDLDRPLKFICWDWNKSSPPDFIGEFQTTTRALLDENKKEFELIEPEKKKKKKKYKNSGVIYHISRPIQTEESVQQTSGQTGSFLQFIRGGCQINLIIAIDFTVSNGNVNSPTSLHFYDPSRPNYLNEYLKAITSTCDILIDYDTTKSFPVFGFGGKPFGSQTVSHCFPLNNNPRNPVVEGVLGVINVYRDALQVCELSAPTTFEGVIRVARQMASIPITQEQLRYYVLLIICDGTVTRGDTPHLRNTIDEIVACTDLPLSIIIVGVGNEDFSDMVLLDADENPLVSSNGKEMERDIVNFIPFRNYKTASPQVLAAALLEEVPGQLLSYMAMKGFRPNPPKRNFQGPREDHQPIARNVGVMPIGMTHNFSFQQNPQNPPQYGGDVRSNSFQFGNQNPQNPQNQSDRLFTDIGLDEVEDDQLSVHEMNPQNQLNRPNSQPNFQYPPNQLIDQIVNHILNIHKIKDSIHKTKDFNPQNQGFNPQNQGFNPPNQLSRPNSQPHFEYPQNQLSRPNSQSHLEYPQNQGFNPQNQGFNPQNQGFNPQNQGFNPQNQGFNPQNQGFNPQNQGFNPQNQGFNPQNQGFNPQNQGFNQPQQNQRFQEQLRQLIDMGFTDTQKNLQALSEVNGDIFQAIEHLNEDEEPPPPDYSQHSHSFNQPQQNQSFQEQLNQLIDMGFTDTQKNLRVLSEVNGDLGQALERLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIV7</accession>
    <name>A0A9Q0LIV7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIV7"/>
    <dbReference type="OMA" id="TRENEWF"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="351" mass="41652" checksum="05BBEDE02E9A9B23" modified="2023-09-13" version="1">MNDLFYEKISVPKKNRMDTFKVGKWVELHPKNEVVQVAKAGFTCIQHQDKIYLYGGKNYQNETLNPDIYSFCLRTYEWEKINTNGKQPEDRCGHSMCAIHNNIYVWGGYDEITWFQEVYIFDTQNDNWSKSQSTSSSLPEGRYSFSMIPYKKKFYIFGGVPSNQRRFNDLWSFDIESNEWEEIKPKGKIPFARSSHSSLLHNDKMYIFGGLGKNIIRRNDLWYFDFFNNYWVEIQQNETVPNLPVGSGILAEIFHDRYFVLFSGYNSKKTWSNSNYVLDLETKEWRKLQSKTKKPPKRYGASCARYFDKWIVFGGQVNNSESLQDIHFFIFEEDLAKDLHNFLRMEELIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ35</accession>
    <name>A0A9Q0LJ35_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ35"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="286"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="338"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="515"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="620" mass="72375" checksum="B8791717397C50A9" modified="2023-09-13" version="1">MNDCLFFGLNDYPKLIKNETDKITKSIQFKFENENENENEKQIKQISTGFFSTIFLFKNGKAIEYSRYSKQNPSKIQIKNIQKVAVGYQNEAILTIEGNVFAKGNNINPKNSKEFINISSLIEDINDRIIQDIVSGIGSIYLLTSNQNAYGIGLNNFGQLGCDSETLKKTEKPILMMKNVSKIFSGNTSNHVFILNSNQELFVSGNNNYGQLGLGESRRKETKIQELTKIQNIPKGKIIDIQSGFYHSIMLIENQNEYENQNKNQNQNQNDQNQNQNEDQNQNPKRKLYSCGDYQWNGLGKNRDTNEFSEIKSSLFENDNIIDFSVGNFHTLILTSKSKLIVFGYNEYGQLGTGDRDNQSIPIQIEIPKLRFNENISNYHISCGYFNSFLYYSSPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLKDENQNENQNQNENQIEKLQEIISKKSIKESNQIFEMIYSNKIINPKLYLEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQILEYWIYSNQIKDEIQITQEMINEIQIGIDYFQLNQTNPNLIDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ62</accession>
    <name>A0A9Q0LJ62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Gtp-binding protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08371</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ62"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="592"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="416"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="153"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="698" mass="83509" checksum="D189546060166A79" modified="2023-09-13" version="1">MGSKNSKTKEIEKQLEIEKEKEKENAKKLKFLILGIRGSGKSTIFKTFDMEYCLSKKEENIEIIRNLSFSILIDFAENENIQFKNEENQEIYKKLIETREINPEKISKLWKSEEIQSIYQKKPDILDPSSIYLLNEIERIFQPNYSPTKEDVLRYYQKTFGINIYEKKIQNFPITLLDFGSGTPRRKWIRYLDNVSAIIYCVDLDCYYQNLYEDESINKMQESIELFEEIINSRWFEQSSFILVFTKLDLFLKNLEKNNFHHYFPDYNGKNEPNEIKEYIEKRFISLNQNQERKIQIHYVNLLEEYDSNKLWNEILITGIERKFGKEASNLYKFSIYGVIFDLINFLKKQELCDKIYKTNDSQEIGIHSLFIKQIIGNEQMKKLEEYLINHNKEEGMKLLEDIYSGIKTEFDKNENQNQNENQNENQNQNENQNENRNKNQNQNQNQNQNQNQNQNINQNQNQNQNQNQNQNQIENQNQNQNQNQNQNINQNQNQNQNQNQNQNQIENQNQNQNQNQNQNQNQNQNQNQNQNQNQIENQNQNQNQNINQNQIENQNQNQNQNENQNENENKTTPKERIISDLISLYSNEESKDFSIISNEGKKIKAHKFILAARSELFRGMFLTVTEDSTNEVKDYTGKSTKALETIIKFLYYDEIEKGLEMNIYEELEEAEEFFQFSEYSLFKQKLNLVKKELKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJQ0</accession>
    <name>A0A9Q0LJQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calmodulin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1536"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1572"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1608"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="1644"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="673"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1492"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1675" mass="195792" checksum="3D9FF6E016E87459" modified="2023-09-13" version="1">MISTSLTLIAKLPENFKLQKLGLINSILLVINKLLKFAHSFDIKNTGSLASYNENLYHQIIQSSFQPKQAKQQQQRKSSPNKENKSKEDQQNKKTQEIEPFLEISKSPISNEQVFLETKKIMYSNFELIPKDIFQKFSKEMIYLLLSDIVSERNNSFIPEDHHKMLFEDQFYKDSDYTRIITNYTHFANQPISVVWNIVNMDQDDILEIATHKMASLFASEENEMKQQIMQIYRHSFFRCFRTPDQRKKQIINILVSILFNLKEELKTLHKKKAKYPPQIQDFYQEILSKLVIVDNNKIRIIANQFIENLYRTMGKILFQGVIQFLKTKIQIEQDNPIKRKSKNKARAKTRTQGSLESQEENLNHFHKSYISTLPIMLPYASQDKKESQTANILEYIKEAFSGNDDTFICWGLNSLFVFLQNIDFIPDEVFFVTKLMEIINVVLMHERKQFSSIELLIIGKLMEYLVTIYGPLIASEQKLFIWTKAMCGYLISVGNQHSQILALSALQIMILHSNNSDCTNDFFTYLFTSFFNVSFPNSQESQISQTQLKPKHKNSSIANWKSAIINEKVIHLCEVLIRKNKHSFHAFLGKKTHPLFFVEVLFEIYDFYSGFDFSKENRSQIYKLIEQIVKDTDVFINGKVSLLPFLNKIIISKISDENLSLQSTFFSESKSKSKDQSNIEKSDSESEDIENIEQISKNPIRAKEEPQKKQNQPAFNNQNSLELCKSRSPRWQTKRIALKIIVWIIQQIEETPNNRVQISQNILNEFMEIALQTSQSTISQHIMKHGIHALNSCFKLLSSLNHEKIDRIHIHQIYGSQIISLLKNLSSFGLISIAESDSFQEAFQDKKEDENKISFYPQTIILSSILARNYIQFYEKTSRLIFQKFKILDQYKSVYNQDQDQDQDQEEIQEFNQEQLSQMDKISRILSDKFSDIYKYKSNQNSIESFGIISLITLLSAISRLRNISVPFQSQQKSLNRIFTKNFDSILNPIQTEIFGIINKYYVQISSGNSDQKTLLKPIQIEHILDEIWDDLVSLGLQNINKDQMNKEFDLFFGLCVMKIGREMEIILQNTENQNQNQNQNHNLPINTLISNITITSITSSLKILREMIRNGYFDPSLTEDYEKNQKFLHLVWIINILPFISSKLNNDKKISKLLIQLIFDLTHLLRHIQILTEEQHQKQEEYVQKLLWILYQNSVSLFNHKNLLKSLNNVIEMLDEKLKLKFIQEIIDILLSESIKNTEYSSPEMIQISVGLLMNNSQFSQKMKLKILLKLIDQISSYKNLEKMKNAIYLFGEFLSVISFQELEENLLIEIAEKIQRFLDQFMNNENQSEQNLLLYLQCILLISSFFQKAILTENDNDNDNNNNNNNEKIAKFISTIYFPLSGKITSLMWKGKEIKTKKQAEIIVKIKMEIMKISMILFNNFGLFGLDQESKNSLLSLIIHSILAHYISFESQQNQFLDIETSLEDILGQFLIHIARNSSEEFKIIIESINQKERSLLEEKIRKNLLEQKRKEELEQANHLRNRVHSMDKLPKELIAEYQKAFDVFDQNHDGTISFAELETVMKNLGRDVTEDDVNRMIGEVDNDFNGVIDFQEFCEMMWRQQNNITEERIKEAFAVYDVDGDGTITKEELKKVMTNLGQKPTDEQIDQMIKSADTDGDGTISYIEFKKTMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK30</accession>
    <name>A0A9Q0LK30_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tobamovirus multiplication protein 1-like isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_00852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK30"/>
    <dbReference type="OrthoDB" id="19353at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="7">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5074223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="299" mass="34904" checksum="6BABF45A9A28AFAF" modified="2023-09-13" version="1">MLSTVSIIGIILYSFVFLLLLLGTIRICQFRRFIQFPSKFQLQFYILLLCFLIIRIIWIVLNDRENRVLTFGLNRFAILSFFTNFTYLIFYWAEIYHDLSSLSNHFSLSRLLKPFIFANLILYLFTIEQIIEFSIDDKNTKETDTVYTVGVLVVGGSSFFAAFGFLIYGILLFCKYKNTVSFVLQRRKALNKIATIATIFSICFLSRFIMLLYYPITHKYFAEGIYMTFSYYIPEVIPSVVQLYSMHPKIPKNFQKYGSKFSDNLMTGFEIPENLIAQKQESLMSDENSDGVTSSEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK56</accession>
    <name>A0A9Q0LK56_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK56"/>
    <dbReference type="OMA" id="CPAYAYG"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000021">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="568" mass="64314" checksum="192474E6E3CCDC38" modified="2023-09-13" version="1">MSFDLCFHDALTEDVFFDSDSGFTMNYYGAKLLNKKKVFNEFRYNVKHALEYIKRIENGELVNSTGVLEESENRAVDHFNLRMEEEVVKGKSLQKSIEVYNDIQEKVEEILSGKKTTSKGLKYTDIVFNGIGGSFLGPYMMIVSQYGADFNFTSNLPVKLHFISNTDPTSFALLLSELKIETTILVSISKSGTTAETVGNMFAFNKELEKKNLEIGEHNIGITTRDSWLHKYGLANKYLYTFHVENETGGRVSVCSAVGMVPMAFARINFIEFIKGQSHMDKLTRMEDPEKNPAMIVAIILQKITLESNHQNVVVLSYTDFLREYSHYLQQLYCESLGKEYDINGLLINHGQTVYGGVGTSEQHSFIQQIQKGIHNVIARFIYCRKRTTDYENQKAGTMGRQLLGFLKGTESALIRNNRPFITCTVESNSPFNMGMLIALEERVVAFLGAFRNLNPFDQPGVQDGKLASDFFNKFSKELIESIAKFFADPKAESFTGGANEALIQFMKIDTVQSSDILNQQLIIADTILSDIEANLFVSYPQLKDLISVSRSFDNSRFVYVIHHKDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKA0</accession>
    <name>A0A9Q0LKA0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKA0"/>
    <dbReference type="OMA" id="IEKKCAC"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001072">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="23261" checksum="B242C662F0FCC2A5" modified="2023-09-13" version="1">MNNKIDNGKPIYKIVLIGDSSVGKSSILHQFCDNQFMEKRSPTTGIDFRFSEATLETNVAKLQIWDTAGQERYRSIAGFYYRNSHGVMIIYDITQKSSFQSIPQWIDTVSKDAPPDISKMIVGNKIDLEEYRQIESLEGNELADYMNADFEEVSAKTGENIKNIFHRMALDISKRLSTKKEEEEIEETNLVSIEKKVVKKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKS6</accession>
    <name>A0A9Q0LKS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKS6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="288"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="362" mass="41682" checksum="C5F4A1239D4B1E8C" modified="2023-09-13" version="1">MYLPKGYDVNPKNTNEFINISSLIEDKNDRIIEDIVSADDSVYLLTSNQNAYGIGSNQYCKFDSETLKKTQKPILMMKNVSKIFSGNASKYVFVLNSNQELFGCGYNYYGQLGLGESRKTTKIQKLTKIQNIPKGKIIDIQSGGDHSIMLIENENENLKRKLYSCGFININGLDKDKNTYEFTEIKSSLFENDNILEFSVGNNHTLILTSKGKFIVFGGNSWAQLGTGDTNEQSIPIQIELPKLRFNENIFNYHISCGFNKSFIYYSPPSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNEFEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKU7</accession>
    <name>A0A9Q0LKU7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKU7"/>
    <dbReference type="OMA" id="PPWVNKE"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="317" mass="36589" checksum="D661755E3415A255" modified="2023-09-13" version="1">MMLMMKGILFNYKEDLTGFISLSNQNQVENKVENQIKNQVKNKIKNQIKNQVENQIKNQAIVFIHGLTEGFLSTSYLGILEKEVTRIGFHFVQFLMRSSYKSAGLETLETDSEDIENLLNFLQKKFNCEKFILIGHSTGCQNIVHFLKTKKPSFSLVSHCILQAPVSDRDYITKLPEFDMNSLVFAQKCIERNKKKEIINQNIFQSPFCAERWFSLCSKEGEDDMFSEDLSKEELSEKFSQILQNILLVFSSNDEYVPNLVSYPNLASRISSSFINAKSVTLKLIEGAPHNLKLHEEEFVNFVIEWILKLESKSNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL41</accession>
    <name>A0A9Q0LL41_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL41"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="583" mass="69708" checksum="ECDC5983FDAD3979" modified="2023-09-13" version="1">MFVWDQNKDQPIQKFSDIKFILSNQQFLSHKHLLTFSGWPFIINILKKQKNNHKIKIEIPEEIFKNILYFIYNKKLHPNFKEIENEIIDFFQKNKNYIYPEILIPIWNHFENEANIDSENQTKINLEKKPSVDFEKNINIDLEKDHNNIILSKELFQPYLKLIKLFNIIKDFPEKISLFKNQFPKSFNYFLSFISNNFFWIPYFKEIPPILSKGTLLEFLERHVLIEKQQEFFKKWIKNYEHEFKSQEKNQINNQIIYIPQDYKDPQESSFINSMIATHSINPEKIKQNELFRPLDSLINIKNKYLDIEDHPVFKEIESKYRIHEEGFVERYKQNKTYFPSEKILLKWISCPWDSTILQSQNIFKDQEDSLQQKEKPKQSPKNRKKSNREKQNKNKRKNKSPSNSQNLNYIEKIYNYKMYLEEWINDPIFMKNAVKILSNSKEPKKFHSICDKQGQTLAKDKGYIEDSKAFIFTLKNGENSPPQKFSIIPSRSKFALQYHDNFGPLFGGGLGGSDIGIHGDLKKGYSFFGTAYKSPQKKSYPFETQKFLAGASKDFEIVEMEVYCIPKKIQEEEEKKEQRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLC6</accession>
    <name>A0A9Q0LLC6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C1 domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLC6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="291" mass="34777" checksum="BC10C8ADE7BE927B" modified="2023-09-13" version="1">MTDFESINSAKIDALRQEIQQMEESLQKPKEKSKPKPIEFKLKKDEKELKTEKELKTENELKTENENENENENENENENENENENENENENENKDENENELKNENENNQNTLKNPKVVILDKPKDILKRHLLRIQKFGETNQKNSVLEEFKKEQRAKRFQTQTIKQTIREKIGLEKKTQKIQKILGSSVEIQKRALRFGIPVKNITELPPRPNYQSQNNKEEKKEEKEEKEEENSLKKPEKKIIQLDKIISTKIDKNDPTVKKRIEKFGPVKDDFVKRPKRNSFKKRFHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLE8</accession>
    <name>A0A9Q0LLE8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_07766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLE8"/>
    <dbReference type="OrthoDB" id="17346at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="8">
        <location>
            <begin position="686"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="583"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5075062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1010" mass="117245" checksum="B51570CC7935BED8" modified="2023-09-13" version="1">MKSQRKHFQQFNDKGFEIHDFSVSSPWEKFISEIEMNLRKLSLDAVQYFSRNNKKQNITKIIEVNGKQTKLKYKNFGSFQKNSDSKFFPLMKAMMETKKEFSSPELLQRWFGLSEFIIIKIKDFSLNEASIILSSLSIALDNCGSPVPVFVLLIDGLKKHYIGYATHNNITTKFDSLIQSNDDIIDFPHLLDMFCMKLEIPPEKTKKISISSHFTYDINSDDIPVDKKYIGIFPYKQKEYESTINYSKYSDPISRILLEVKWPYFQDKKILEKDSLTLFNPFLSKFWRLRVEFLESPQCLLCEGLTQLMNFFIKGKKIESLLGLLEKNTNKTKKSGKIIGMFGRIKNSLQNSLSKKSPLPNLDIKDIIQDLFIFNQDENLNENENENSNENQKDNEKLDRKESLNLPRLSIKTAPSNTLISRLALHCAFQENLKKIAQIWNQFLIHLRWCWENGKKLPGIPLSPPDLRYSLIYQKLQMLNLCIEKKTREKNEKQNLKENSKENLKENSNENSNENLNENSNENSNDNLKDILNENSNDNLKDILNENDSTEVANGWDIGEDILDEMIGEDDNKQNHQEYIKENVNIEKENDSIESSGNDSDEDSQEQPDLDLDNLDVPDFDFQNISSDESENESENNLGNKLENNLENESKSESNNNLESESNNNLESESNNNLENEKIQNFQNFQPSGQLKFVDGMLLLKTGEKMWEPITQDPLHLTEDKLIEQQELFVRLGTSEHGANIRAQIQSKQLLADMQAFKAANKNSILEDFVRWYSPRDWIVDSSNINQGKLSSRMIKQNNIWVKTWEEANPIPAQNQKPLFDHIKEAEVALHYFDTLSSKEILRQLLGIAISSTVDLLINTPVSKCSKIKNQLINLINQINSLYSTKMKKNEIEKLIEMIQEIEIEIIQLNSLWKKLNGDLEMIQEFLSSTNFRIKINDERKREIVLHLFNEFSQENENDFSLPEPENKEFIFRISSPYPIQSSNPVSHRMYAFVSNGVLRISTAISESYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLJ5</accession>
    <name>A0A9Q0LLJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLJ5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="221"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="273"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="388"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="561"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="635" mass="74171" checksum="EF3AE23BB89AF8F9" modified="2023-09-13" version="1">MKIKIKIKIKIKIKIKIKIKIKIKIENKNETENQNQIENENQNQNQIENQNQIENENQNQNQIENKNETENQNQIENQNKNQNQNQNQIQNENQIQNQNQIQNENENENENEKQIKQISSCYFSTIFLFKNGKAIEYLSNEYSNQNPQKIQIENIQKVSVGFRNETILTIEGNVFAKGKDINSKNTNEFINISSLIEDTNDRIIQDIVSGSFSIYLLTSNQNAYGIGLNNFGQLGFDSETLKETKKPILIMKNVSKISSGNSSHHVFLLNSNQELFGCGYNQFGQLGLGESIKEKEKIQKLTKIQNIPKGKIIDIQCGGFHSIMLIENENENPKRKLYSCGNYHYNGLGKEGDTYEFTEIKSPFFENDDNILDFSVGYTHNLILTTEGRVIGFGDNLYGELGTGNTNHQLIPIQIELPELIFNKYIFNYHISCGYFNSFIYCPSSFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNQNQIEKLQEIISTKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQILEYWIYSNQIKKGIKITQRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLV3</accession>
    <name>A0A9Q0LLV3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras and ef-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLV3"/>
    <dbReference type="OMA" id="RYMETSA"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="204" mass="23456" checksum="3470D68C5970BAEA" modified="2023-09-13" version="1">MSKETSFKFILVGSKGTGKSSLITRYTKGKFFSECPQTLGVEFVTKDIYIMKEKLTVQLWDTAGQERFRSMTRNYFRGSDAVFILFDTSRRDTFNEVSLWITDAKEYTNKNCVKVLVGNKIDIREREVSTEEAEKFAFSNEIRYMETSAKKGTNVEEAFYQTAKFLYQKSKDVMRKSSRNLLSKTQSAIIETTDNQPKKSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNH4</accession>
    <name>A0A9Q0LNH4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cathepsin l</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNH4"/>
    <dbReference type="OMA" id="VYHEKRC"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040126941" evidence="3">
        <location>
            <begin position="17"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="5">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="316" mass="35449" checksum="1383C2BBAF54F423" modified="2023-09-13" version="1">MKFILLFAILFFFASCANDRMLFNNFKTKFNKKYSVEEEAMRFKIFQTNLKTIQEHNAGDYSYKMGINQFTDLTNKEYQQKYLSPIQYEVEPMPEENIKNIGGGFNWVDHGAVTPVKDQGKCGSCWAFSTTGMIEGCTVAYGGSLISLSEQEIVDCDSGSYGCNGGWPYQAMQWVTEVGGLCSEQDYPYVGVDQSCQNSSCQPVSTLTDHRQFSSEGQMEYQLQTNGPISVSIDASGDGFKQYSSGVYTGDDCTKTKLDHAVLVVGYNVDTHPSYWIVKNSWGTSWGLNGYIWMEYGKNTCGILIEAWWGIGCHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNU8</accession>
    <name>A0A9Q0LNU8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cerebellar degeneration-related antigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNU8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF8">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1005" mass="114632" checksum="3CD66E9C6BBEC201" modified="2023-09-13" version="1">MSFIDFIIHVNKSITYVSVKETYSIEEFKQELSLYIGIEPKKQFIKGLKNENEKEILKNMNLNQPHHITIKSQNDFNLKNSKNLKKKDLDEINYHYSYSGNSSPISQNFKKNSFENTEGTTNTNQPHSQSRFETKMRLAQKNIRSYSTSNSNSNSNSNSNSKSKSTSKSKSKSTSKSKSTSKSYKSSKSTSKSTSKSTSKSTSKSSKSTSKSTSKSKSKSTSKSTSKSTSKSTSNSNSKKKEKPNSDRNFDFNSDSEIDSETETDSDSDSDSDSDSNSNHNSNYNSNYNYNSNSNSNSNSNSNSNSNSNSNSNSNSNYNHNSNSNSNYNHNSNYNHNQNQFQNQFQNQFQIQNLNQFQIQNLNENKYNSDKNANQIQIQNINRKSESETISESDSPSYSQTNININQIQNQKSSKSKSKSKSKSRSNSKSKSKSKSTSNSISISKSKSKSKSNSISTSISTSKSKSKSKSKSNSISTSISTSKSKSKSNSISTSKSKSKSKSKSKSKSKSNSISTSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSKSESKTVSESDSERNTNQKQPINLTLNGINVLKKLSVNSLKSFNGKNFNFNDWDLFQKSKPKGFELNFNKSLNLSKQTDNLNQEIKFPYGKKDESSETDPFISENTSNSDENDQSIFSNENDKKNQISQSFSSDEQEKSQIDKMDNLQKNIHSNSNQDEITDPYDFMLNFSKNNINSVHPNSILIQKFPKIFGKKYQRVSNKEILRIALKKNKSVIFIIGDLQTKENIRMIKKFFLNPEIGKIIRTHFLVWACDVQYEENIEALYLAFRIKEFPFLMFHDKKKIQTLEGEGITEEQFKIKLKRFIPDKKLKQFQGLLVLPKNDDSNSRIKYEKNLEYEKSIRSDQAKKELIKKQKKLKKSINKDSKCYPNEPLVNDPDQISIRFSCEGRTYDRRFYKNDLLDSLFLHLITLNQNYKEIELIDIASKQIFSYDNWENRNKQINEVGIKQNSRFIVRTKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP13</accession>
    <name>A0A9Q0LP13_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP13"/>
    <dbReference type="OMA" id="YDRFNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10254" checksum="46242FC7F21F4438" modified="2023-09-13" version="1">MAEEERRLSLNIQQEHIISKYVGTGNTDMSKHDWLVNQHRDTYASYIGNPSMLYFISIVENEPIAKLKYNFLQKMVQPCGPPPSHKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPK2</accession>
    <name>A0A9Q0LPK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beach-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_07539</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15734">
        <property type="entry name" value="FYVE_ZFYV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH-type PH" evidence="12">
        <location>
            <begin position="2355"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="11">
        <location>
            <begin position="2527"/>
            <end position="2821"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="3276"/>
            <end position="3310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="3398"/>
            <end position="3439"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="3598"/>
            <end position="3653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="663"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1780"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3090"/>
            <end position="3184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3090"/>
            <end position="3132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="3133"/>
            <end position="3159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3161"/>
            <end position="3184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3672" mass="431718" checksum="3A3BBE8C8CC0E01C" modified="2023-09-13" version="1">MGKNFETIAYQKLICLNYFLQNTKRNIIKISQTQLPNLIVDIFISFNQLGTKIIKQKKIHQIKKIFGYFATFILKFFIQEKTLAIFIKNGKFLLLIQCLQKSTTKTETGKYFSHTLAYILQTVFESSQNDIMSKFIEDQFIVKYLLLSMKEMPEKEPDLFIYFANILLHSILKYFKFRTPKILTHFNEVSGYQILESSTLQLLESSQYSDSLSDYLKILSNLAQIDMINPNDNDKKRNFSHQSKFNLKALQMLQNIFFHSIKHKEIPDSISNEILRLISVNILKNSPDDQIDILQMFIDQMETFPEKIQKNILGLFEEFIIKLPDSTKLLEIFMSLISKNISHFVMKIFLESINRIISTQKQLKNKIGKLDIFKYICEHLNKLIQNLPQDENQSIQQKDVIRLELLVELTLNLIEECSNNLADFLQIGGFEKLISFLNYAQLNQKTLILVEKIILETKSQTEKLFEILFDLFEEIQPTKSNLYIDILNLFSRLFIKNANLKFLFYEKQGLEKSLLKLFNNFSQFGCWKFELSTLLSSIFQCLIDSILNCPQNKIIFEEKYMSNLEKIMENSGLLSTEDSALVIMSLLLDLSLEWRFLWNFEFICFRDENNENNENNIENENNENIQKDIEKENNENNIENENNENIQKDNENNENNENIQKDIEDNENNQKEDIENNENNEKDIEDNENKNNENIQKDIQKNIEKDNENNENIQKDNENNENKDNENIQKDIQKDNENIQKDIQKDIQNDIEKDNENIQNDIIDHPKYYSLKFSYPKIIPFLIDNISKIPLLKQSKFIKRIIYLCEKEPVNRKILYKYSTCGLIINKYQNIIFQNQAKDVSPLFESLVDYLVLFGKDSFGAGELRQLFQHFRKLNTFPHLLIDILIKIFQKESYCSIIFDYSSYLEDTKSQNETIKLLFKKYKNEKNTEKITICNFPKNFKWPPSEYSISIWIRIDTINNQEIPSSAILFHIKNKKDNKTNMAIILQEKFIIIQISENSFKFEIENLQENQLLHIVFVHKNSLMSSSRAKIFIDGQLFKSEKIHFPHQISEVDKIEMEIGNLISIKSISKSPHMKWELFSIYLFSTSLTQEDVFSLFLLGPNFDSSLEGPISLYHKDTNFSSENLSRLSKESSEEQYRILDIQHKTIALKKSKIIFAFSPNHTIKKSANITTVKIDNQEKLMETKALFNIASANGTPFGILTGKTSIFSNKGILYQFAKLCGPQVFFIFLESVKETKDFNNVLHLINLVITNSSTMKADMTRINGFNLIRYFLQEKKSLIDEKTVELLFTFSGLNINSPEKSVVTSLCSINKIFIRNLVWSQVSGSIQRKVFSTIKLFLKNNNHIMFNSMRLREIGVVQFAIYFIRNKQIEAETIFVISKLLIWLFHADPIQHSLKFLANFLWATFQISNSINNLKVFRSKNLTYWLHPSTKLLLPIFKTNNLLHIIHILVLKNKANDKILQVLFDIFDPHYLLVFLSRESHPSTVSLAFLIISNLIILQPSFYQKFSQRSGFIFLSKSLPKMYKNEHIYTILINLVFGKITNYSQLVVESTKKAIDYFQHNKSGIYSFEAISLLFSIFHNFQKHYFDHYFKSEIEKTTNLKTHNNNNNTQFHEFSVSVNDLRIRLQKERKSHLNQKSNQDPFSWLFDIIHQILDLIFPLFSGFEEYQPFFSSSTFIEGILSVIFPVNFLELFKFFVPDVYWIFDNKSNTENSNKIPQRTNFLESNALNITKNFHFGNENGNEKISESKYLKHDLSFEENIPRIASPDVPVLSKDSSFKLENDENSKNSDNPNKKTSKMPNQSFSSDNITALNKHKFSQTEQDAVIRNFTQILFFNPITSKLLLFLVDICFKNLRTSKMFNNVEREIFISVPRSLYSRSIYYLQKVILLRIMMKIEGVIKELPLFSILIPDSAYDKNLIQFSFELKNKLFQKIFTWKEQKKIVSFYISLLATLKEKIQCQLSNMKKDKIKEKYPNSMIFPLYMDLDQIALHILSPISHQNEDKTDKNTQNRIVYILTIINNNKKLFLNSFNSSYSFLSPFYSRIFKYIRLKNQEIVSVAENILRDSLIKKPSYIQTLLSYRTKSGKQKTLFHQGIMHFFEESTKKRFMKFLRENEDRIHKIIESHIPKNHENFNEISIKLRENEISERKLLQSKIAKRKAQEKQEVNNIREKNSSAFFQSKEDEVIIAELSRLIYSQPSFSRNNWKKLRRDLVRERAVWGNDQDPDPKWKCDLTEGPYRMRTKLRRNYKFQKHMSYEEKRLKSQQKKANNIEKDNNININDNIGNTMQEQNADFSDDSEKVIQETKNSSLEKMNNKKSTSINESLLSPIPETNLHTMQNKIQEITKNYPIYQKFEPYETIHNKVNCGKVTENNAKIGVLVISSRNLYFIKNHFLTPDGKMTAFSEINAEQQNELENHRSLRMLFAIQKSLCEESQTKKQNKKQYNFGQNIKKWRISIIDHIFDRTFSLQPIGLEFFLNNGYTFLLFFNSQQQRNRVCNSITSISPKITNEIDKITGSKLTKESKTTVLSTRLLFGDLEKEKWHNGEISNFQYLTYLNTVAGRSYNDLTQYPVFPWVISDYQSQELDLENPEMYRDLSKPMGALDPKRAEYYKMHFQESCDPNQKNSSFHYGTHYSSAAIVSHYLIRMEPFSRQHVRLQGGSFDNPNRIFSSISNAYRSASKENTADVRELIPEFYTLPEFLINSNNFDFGINSQEDVPVNHVHLPPWAKDDPYEFIIQQRRALESDYVSRNLHHWIDLIFGFKQRGKYAERAMNVFYYLTYGGSVKLNKIQDQTELISKISQINNFGQTPKQLFTKPHSSRRCFRLSSFSKNESNPLTEYYSKNQNQNSITNSQEISNIKKNNIFQEYNNYIDRIPKKESEKHIKSRFFQSVDKIIPSFTFHIRKKKIKIKIKINLKMKIKIKIKIKIKIKIKIKMKIKMKMKIKINLKMKMKIKINLKMKMKIKINLKMKMKIKINLKMKMKMKIKIKIKIKINLKIMKIKIKINLKIKIKIKIKIKIKIKIKIKIKIKIKIKIKMKIKMKIKMKMKIKIKIKIKMKIKIKMKMKIKIKIKIKIKIKIKMKMKIKIKNQNQNQNQNQNQNQNQNQNQNQNENQNENQNQNQNENQNQNQFENENENQNENENENENENENENENDDSDNPSKNSKIHNQIQQKNKNRTTKGTNYQKLQNKSVIAPFNPNSKFIPIIYPHLLKLNTIKKIKEPIGDIYISNGKLFVVGKYKRIIRENPQNQISFKNSDNSLKIINSENNKTIRFQEKLHLTEITSVCYIDGNHILITGGKDSIISIWKIQKKVIKIQSLTENINKKTRKLVIENEDQEDKPFTYLQNLLLFNKEFGFETKDPQLQKISSKIPKCIDNLNPQNNQQKIIKPHFQLIQKLYGHSKAVACLAISVAFNIVASGSKDGTCIIWDLNRFRYTRQLPTFQHKVRNISINDFSGEIVTCSKSTIRICTINGHLWCEKSISKNKNDDIFSLSMTHFPNWDPRHLYISGHRDGMIRFFSVQSQMVEISKSSEVDKNMDVSKKLVRTLNEIQVIQTVDSPITCIFNDSNISVYIGNSSGDVLQLGFLEQGDKSHWTPSSSIHKCSICGKPFSLILRKHHCRKCGKVVCDSCSLFRTPLIDQHFFHPVRICDNCKLENFSNEDENQDENQNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPN2</accession>
    <name>A0A9Q0LPN2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPN2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="236" mass="28014" checksum="B230EACE8CE8D0A8" modified="2023-09-13" version="1">MTVYYGNLQKASEIDIPVLIFGENYQNLYLEQNRKNKNLNQNQNQNQKKNQKKNKTKEKRKISAKKQRKHKPKKKRHALKIEKKPEVDLFPIKIIENTNEEKNSNLNSNLKQNGKKSQRKENMKKMKKQKRKHRRDESFELSMDQNLEIIQEEMNNLNLDEYLDENSNENLSENSNEYLDENLSENSNENSNENLNEYLDENSDENLDENSNENSNENLSENLDENLSENSDEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQS5</accession>
    <name>A0A9Q0LQS5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQS5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040133065" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="83" mass="9789" checksum="7BB39621DF2F4385" modified="2023-09-13" version="1">MIRFFLLLFILFLSIPTLQNDSTQIETLEKEGFEVDVKKIDDNTRCPTVDLLTSDGEVLFSKYKSGRYPHKEDIFEILREFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRW7</accession>
    <name>A0A9Q0LRW7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRW7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="150" mass="18077" checksum="F69AFF99B3FAD692" modified="2023-09-13" version="1">MIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITQEIIDELETGIDYFQLNQTNPNLFDLLINKFKNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS96</accession>
    <name>A0A9Q0LS96_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS96"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="268"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="489"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="69375" checksum="99E835FAED85982A" modified="2023-09-13" version="1">MNGCLFFGSNKFPILFKNKPYKITTPIQFKFENENENENENENEKQIKQISTSNFSTIFLFENGKAIEYLNENDSKQNPQKIQIEENIQKVTVGFQNEAILTKEGNVFAKGYDINSKNPKEFINISSLIEDTNDRIIQDIVSGAEFNLLINFKSKCLWNWFKSIGQLGLDSETLKETEKPILMMKNISKIFSGNTSACVFLLNSNQELFGCGDNDYNQIGLGESRKEQWQIQKLTKIQNIPKGKIIDIQSGFYHSIMLIENENENPKRKLYSCGNHSRNGLGKDEEDAYEFTEIKSSLFEENDDNILDFSVGNAHTLILTSNSKLIVFGHNSYGELGTGYTINQSIPIQTKLPELRFNEDISNYHISCGFNKSFIYYSLSPFSNLEEDLIKLFERKEFCNISFKTENGEIIKAHKLILKYRLNQNENQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYFEIKEIINSNEKIEETIKRIYLNKNEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSB7</accession>
    <name>A0A9Q0LSB7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSB7"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="166"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="338" mass="39201" checksum="493BF053CA1453E6" modified="2023-09-13" version="1">MEIEINQEDNKKSNKDYYFDSYDHIAIHEEMLQDQVRTGSYYKAIVKNKHLFKDKVVMDVGCGTGILSLFAASAGAKLVIGIDNSDIIFQAEKIIKANNFSHIIKLIKNKIEDIQELPDKIEKVDIIVSEWMGYCLFFENMLESVIFARDKWLAKDGLMFPDKFGFFLAGIENPNFKPDKIDFWKDVYGFDMTCFQDLVYLEPSVEAVDPETIVTNTILLKEIDTQVLKKEDISLKSSFILTTQKNCNLNGLVAFFTTTFSKCHKKVHFSTGPLTQQTHWRQSVFYLEEEINLKRGKTFRGVFSLFPNAKNSRDLDISIEYKTEPQKIFSKVQNYRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUE4</accession>
    <name>A0A9Q0LUE4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUE4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10369" checksum="F6BC4A3271FF1DFF" modified="2023-09-13" version="1">MTGKFNPNLNSLKIIQPKQNINFFALFNQNQQELPPFQLENYNKGKIIEENGLTQIQTSDSVPDFLVYYSYDIELKKDEEKIQIEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV83</accession>
    <name>A0A9Q0LV83_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ancient ubiquitous protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV83"/>
    <dbReference type="OMA" id="KFNSWPF"/>
    <dbReference type="OrthoDB" id="1854593at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15486">
        <property type="entry name" value="ANCIENT UBIQUITOUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15486:SF96">
        <property type="entry name" value="LIPID DROPLET-REGULATING VLDL ASSEMBLY FACTOR AUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="4">
        <location>
            <begin position="94"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="286" mass="33503" checksum="2775D69D64FB7AEA" modified="2023-09-13" version="1">MKTVHKDVPLTSLFNYTRIIRPYTWNHLAFALWFFTIGIPLAVLRYFLFIIALINLGLSNIFPSMKKLVGFFNYLLGFRVQKINLDLLKKSKSKILVMNHMTDFDGIPWVDLKGKFLVAPYFKLLNKLTLSRTIPFLFVNDPDIKEKIKKSIKDGNYFVMCPEGSTTNGKVALMRFARFVFSLNEPIIPVTLKVETKWFHAINLDKINDNFFINLFFFFAHPCISYKYTIYPEMMIKEEETDIEFASRVQEFFAQKLNLIASPYTKLQKHQLFREIISGTTKLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX65</accession>
    <name>A0A9Q0LX65_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vesicle-associated membrane protein-associated protein b/c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_14077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000010">
        <property type="protein sequence ID" value="KAJ5080482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX65"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="7">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5080482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="196" mass="23200" checksum="72E48E45A5091CCA" modified="2023-09-13" version="1">MHRKYSKEITLKPKIVELPTLFNQYWTTQTILSNLSKSTVVFKIKTTAPKNYCVQPRMGRIPPNCFITINIFYQPINTQERKHDRFLVVCAFIPDNTNEPDINELTSETSSNEKYYYKFKIMFSQNAKPQETNQIIDIKKHLKLLKQKRHNQTNKIILSNIKKQSNHKEFLNKLLSKSVLAFFALLVFFLIIFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXY8</accession>
    <name>A0A9Q0LXY8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000032">
        <property type="protein sequence ID" value="KAJ5079478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXY8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="103" mass="12746" checksum="A80A58D4FBCBEE99" modified="2023-09-13" version="1">MNNFQKEQIIKFLKEKEKENIPFTFYEFKQSIKQINEIKQNNEIEQINEIKQINEIEQNNEIKQINEMEEINEMEEINEIEQNNEIEQNNENKQNKKLNIFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYD8</accession>
    <name>A0A9Q0LYD8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYD8"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="96" mass="11504" checksum="69C766BDDCEB7447" modified="2023-09-13" version="1">MRSELYRGMFLSVKDDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIQITQQIIDEIKTGIDYFQLNQTNPNLFDLLTGKFNNQNQKKKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R424</accession>
    <name>A0A9Q0R424_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R424"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="481" mass="56373" checksum="4C41C5AF4F69F3CA" modified="2023-09-13" version="1">MCRARKIPFGENENQNYYFEENSKSIKTKNLLKKRNIKSNLKLKPKPKLKAKSKSPADPTKKTFQNINQPISKISMKTKSPKNQNLNLNQNQIKNENEDENNKMKIDQSKKEKENLKNKLKKLTKSNQKRKIKNPPENSLFEQKTQSFQTNQNNFEFELETPKRPKLDRSYSFSGNNFKTFFPNQMQQYPTYQEPFIFYMQDQNNFNQQNSFIDPRYQFPNNFANTFTKSKSESNLHQNTFREDYSGLSFLSEMAANYLNYYEEKSKEIDPFENQKSNSQNFSEKFSPSSPQLSFHLVDNPHQQTSPFAQFSNTFSNINPFDHYPNNQMQNTQFYPFSKNIENGNQIVRPKAVYQKETQQNNSFLPKTTITKEEIASLQVGDCVGMRTHGGYEIFATIKSIINQGSDFPMFCSVKWLIPNNGNEFGIISQNGNIHQFKNPFVNDFLIGQDEPIPQPLTCITRKLDFRFEPNWIPNNQLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5D6</accession>
    <name>A0A9Q0R5D6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">21.9 kDa heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03296</name>
        <name evidence="6" type="ORF">M0811_03300</name>
        <name evidence="7" type="ORF">M0811_03306</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5D6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="38"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5066962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="157" mass="18553" checksum="936C8BC01E8A6E45" modified="2023-09-13" version="1">MSISKYPSLFSPFWFNPIKEDSFSIFDKDEPLWISNLERKTKSFAQLGIKETEKEIQISGKIHIPKESINIEFDKESRMLSIFGEHEVKKEEKEDEKEKRVRCERSYSSFKQSFKLPELAEIEKSDASFEDGFLSITIPKKEEEKKEEKTKLSINFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5X3</accession>
    <name>A0A9Q0R5X3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5X3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="184" mass="21766" checksum="8DAD00D18DE12E40" modified="2023-09-13" version="1">MEIQIAFQFKNCVYSTQIKKTISYEEFEENLKQFCQISKIKGIYYLDQEGDWIRITSSKELTEITTKTNDILFIKIKQPKEIKIPEKIREIPKPKKTLVVKDPKKNPLVILDPFDRKVHNINAMLLTLNIKKEKSVIESLLRQHKSPDIVLEILTDQNSNERIQPRPINWPSYMNFIQSLNHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R695</accession>
    <name>A0A9Q0R695_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R695"/>
    <dbReference type="OrthoDB" id="10253607at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="186"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="559"/>
            <end position="566"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5067544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="585" mass="66640" checksum="333B15F0F2E18085" modified="2023-09-13" version="1">MSFKIFLSGTNQNNALLLRKSPSILARKPFSINQILKYSIKRKEKIIHLVCGSSFTIIVLSTGKLLIWGLPNLQSQNITDSSNFQDDTILFDNDKSSLKSNSRFLNQFIIQNKQFTRKSIQKISAKDFSIILLVENQVFSHVLPMIPQKESSKIKFNKISFDKVTKRKIVNVCAGNQMWIAIDENGDTFSWGENNFGQLGHSDQKERTNPEKIQKISEAKLASIGGNHIMVVTKTNKVYSCGKNKYGQLGLGDFENRNTPELPELPYDIGSIKQVECGNDISILLGEDGRVFLCGKAIHSHYKIKQDQNKFIQCIISQENDILISQVFAGGFDSDYCFFLDNRGKVYSLGSNLYGQLGIGVDDKEISIPQLVSIPEKYIVKSCACGWVHSCFLVSKYEANLIQDTNQNQSQKEKFIDLENIQDTNQNQSQKENFIDLENLGNFAILSDDEIIEILSYLPKHYLGLLASVSKNFLFYSSLDCLWKEIFLGDFLFISKPEQQFIDENLNQENGYKKAYIYHRKYYNILIQKPLLTEKENKLRELSKKTKIKKSEIRCLMLGLDQAGKTTILYELKIGEAISQLTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6I2</accession>
    <name>A0A9Q0R6I2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6I2"/>
    <dbReference type="OMA" id="TNCHIGS"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040471535" evidence="3">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="230" mass="26899" checksum="1D37841526179F16" modified="2023-09-13" version="1">MNSFNFLFFSLLFLYSFSNSDTDFDFYHLRLTWPTSHCLPPNNCTIPSWYTMFSILTFIPRTEDNTPTNCSSTYPFNYAEVSTFHSLLAIMWPDIWNFTNPEDYWKTNWESHGTCSLSELKTEKDYFRQAILLHNRLNPADFLANSQILPSNSIPYSYNQLDNAIRSVTQKNATFHCGFYGDQVVLHEIGFCIDKQFNVFDCSQAMRDWESDRCGSDHDSQSIFYLKSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6K3</accession>
    <name>A0A9Q0R6K3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Late secretory pathway protein avl9-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6K3"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="9"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="511" mass="59482" checksum="79222EBA8B2E63AA" modified="2023-09-13" version="1">MQNLKKPVHSISIAEFDISLGNNLTQRYPEFTFKDYDIKNLASLSIPDGGHSREEDLCYMILNLENEEEFKNEKEPFLYGLAYFKSIPSKETTRGAIQISILLLSYYPYFTLFLPFLRGGLDDYLKTKSINSLKTLHSSLNSMLFKKQSVKIWGQSFPVSLPILQDDEILGSSLIRLIKSFKEDVMIIWHAILLESRVIFVADQANIVGSSVISTPSLILPIKGLRKFLIPYFSLTDISPIKKNTFIAGTSNFILEEKTDLWDFLVSFKQGKVIQSHNNFSEIKLNSDDKVFIQEMIQKIEEESVDEKWVRNQFRKFTEIFLFSVKEKKFPSKKEEFVFDFCQTSLFKDYVWKQENSEEKSYPFRIENKKPVLDVRSIINQARTLVSPANSPKFDLSSNSRNQTKSIEENELEVENQVENPRIKNLEDQLKELQEQIEDLKNEAVKTENQHIFEIGLMKSLNKSLTTKVNQQKLKIEELTKENEELKKLNPKEDNNNNNNNNNNQEEKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R735</accession>
    <name>A0A9Q0R735_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Condensin complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R735"/>
    <dbReference type="OrthoDB" id="10681867at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34660">
        <property type="entry name" value="MYB-LIKE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34660:SF3">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1152" mass="136360" checksum="C38E16308BE5F944" modified="2023-09-13" version="1">MNSIKSFIISSRFEDIENDPNLKQFFEQKSNSKKRKKKKLKNNSTFHFNIKKKLKLEKPIIFKETYFQIKNINEMNKKNESYLVENLIKNLQDLNSNNYFKSKKKQNFNQNDLINLLKINFFFLIHYFQRKESLSKMNQEKKEGKEKNLKEKFSLSFEKKNQIIQIIDQFPFQNWNFQDQEKIKDLIIILILSIFQNKENFQIKSRNFQQDYKNFLVSLQNLLIDSLSTSSFNEITTVFLENFNQLKEWILEFSYRLIVEKKTLFFFWINQMIENIIEKGSESGNSLISPCLNFLEMISSKFSLDFSVFIFPLSKTLTFPKAKDRRCFLNICFNILISLQSTQIPPELIAILISRVRDKDARNRARAVCLTVDLLSYHVFDESIYSLIFNEVVARLSDKNQVVRLQTLKKLPLLCESNPFTHTFDMEQINKIYENELSKFNQNQDDPLFIQKFQKIQQTKKFIEQNFYQTVVSKLYSMLQIPKTSPFYSEKILIEVKTFFIQMKTINFNFQELIRSFGINYTSDSVREVVTQIFREEFYILKNTKKEIEQEISQIPFIAMRWINLANLCLNSQIEKHSFIKLVDFLSREEGFQFSQLLDIFFTILTSATFSTRTLGSAFLISIIANHFQSKIKIHLPEIISLISQHNDLNNQEDFDRQISSQIISYCFSILNSFSSSISFEITKFLSKNNLLSFIRNGFAQECLQIIEKVQNPRKLLFEALLDLEYSCFGNLDFKSKESFSSCSENDLVLFLEFIGHSALYISEIIRQKSVNQFQEEANEKNEKISQNWESQEKKKEDENTNEIEKENNIPFEENERKNEIVKIIINDFLENSNISRYIPLMKYICENCEDFSDKILYSTLISLAKLMVLSPQKFGSDNLEVVINVLERKKASQKISLSILILLTQFQKYLPENSRIMDLLYKSVYNQENDIELRKQSLRSIYHLISSKIVKMDLPIYRLVSCLIEPDLFELTKLFFNNFLTQSANYYQQFFFNCFLVLEGNSQRKLIMEKVIDSFSQELREGEVSSAILEATFFKIESSNSPKKRLQEGFFLLSHLQPSSRSLDELLKKIQQFDSFPKIIDKKIFNFILDHLKMKKRKYLLDEKSKIDELIKLVESFYKENSKENSKENSKENSKENSKENSKRRNGIDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R788</accession>
    <name>A0A9Q0R788_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R788"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="94" mass="11462" checksum="3D2F68028E7D7A93" modified="2023-09-13" version="1">MFKIHQIKFMIIQGKSFETINQLIYFLYHDEFDKTKEITNEMIGELREAKEYFQLNQNSIINLFLEDLFSRSLTTKTQKELKTYDSVRHRCQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7D7</accession>
    <name>A0A9Q0R7D7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7D7"/>
    <dbReference type="OrthoDB" id="188207at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="725"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="528"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5069909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="775" mass="86196" checksum="2C34390452EE512E" modified="2023-09-13" version="1">MKKIQNKKLILILQFLLIIFSILNLNEKPIKNVKEWIEKEKINVKNGFSNDRFGSSISIFDNFFVSSSPYASVGSNSSQGKVYVFNFNGTNWNLFQNLTAIDGASNDQFGWEVSIYDNFIIVGSPYASVGSNSSQGKAYVFNFNGTNWNLFQILTASDGASANYFGIGVSILKNYIVVGASTATVGSNPSQGKAYVFNFNGTYWNQSQILVASDGGPYDGFGKSVGIAENFIIVCSPYATIDWRSCQGKAYMFNYDGKYWNQSQILVASDGDAQNNFGNSVSITQNYIVIGAYNAYVGSNNSQGKAYVFNSNGTYWNQLQILIASDGASYDLFGRSVSNSENFIIVGANNAQFGNNSGQGKAYMFNFNGTYWDEHQIVSSSDGDPYDQFGCSCSVWGNSLIVGSLGASVDNNSYQGKAYFFEGPNIPPTTNIENCSSLFSSFGCYWEETIQNFSEIEFEIKYNSVCNVIQSPVLVDNVFYQVFNSSLYPNITGNDDYSIQIKACNISLSSFICSDFSNQTNLKTRIDCVKNFTSQILSTSSIKISWKHPNVPIIDSIPKLNHYLISYQKQNSNQTTNVAISNSSTFYNLNNLERFTNYSISICGCRTEQCNGEDEGQIFSTLILTTFASVLNFSCYVSHTYDISCFWNKPNDPIIPSYYNFTYKAISQKDFAILSVNTTNSSFKAKYSDQEYQIDVSACNSNEECGTIKSFQIKTSKETKKSKTVIIVCSTVIPITVIGLIILSFILLKKNKRKTKEKEKDDEKTILISNKSLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7H2</accession>
    <name>A0A9Q0R7H2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Epilepsy holoprosencephaly candidate 1/tmem1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11379</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="5">
        <location>
            <begin position="466"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1428" mass="166776" checksum="26FD460B5B20E7B8" modified="2023-09-13" version="1">MQNPIIFVEDVSDVWKDVSISLQKHFPLTNINSRRRDKIYESMTINPQFITDRNIISTRNTSKKQEQEPFLYLYVFKCDETNLFKKSIKPQLKIWWENKNSLRVDWLILFATVTYYSGNKMFASRRQKKIYDLLQKEVTVKNRCSHVRVVQFQEGGDFSAEDPSWADFLSKFQSNICNAFGQRKENISMKILEMEDKKEADFFDIFVAKEQKAFLFEQFDLIEKAVKQYDKLEILLKETINFYKNKTNNTNNLIKENQAIIKKNKGQLFQEFVSENSPYWGINILSENAKPYRDLLLSKKITEFDCRLYIMIRKSKLFLKKRLLKDLAKHGLIFIQSMKRELLLNTNFTPIFSTIWAISSSFDIISACTLENPLALLPENEAKQLFAMQGQLDIFVRDLIFSLKHLVGKVELARKLSIFVLEKQIPKSIQSADPITNSIFNKFFAENIKIQQAFQNDNEFWLFYISLTQSTINKYSQSNKLRTHSAQKLEIDLANAYIINEKFVQAEEILRLLLQNFMEENWFSLAKDLIPKLLLCYSKMNSWDKYIITRLVSLSPNFEYPEYEKNLIILDIQNKIKNCARIFTHSTNSLFKIELKKSHNQESVPIGFPIDIDCEITNLIGVPFSCERIVLILTSKNTKKEKSSPKKREYKFEIGKEIIQEIIQEKDKNNEKKDKDKKPTIILQPGTNSMKFSQISNIIGRFILSKLKLYLGNLRVVKKYQKQHHTFCRVSPKNSFLDFQLFQPESFSPNKPCVIQANIKTQNDSINSGTLKIFSSNIQILPKQNLQIESSNASIYSAHDIKHLLSTISRNKTDSLQEKDQITIYIKDQEQKFTSINIPLTCIKVSKQSPFYNEAKIEMKDIPKNQEVIFFLPIVPIPIPIPIKNGINFDNPKEKHELSNNIQIKFDYTKQEPKDLHTIFQNQYNLNTKVPFDISTNVKNIQIDKDFFKFVQIVLESKVSFPIEIVDQNIMISDIIQNDEKIVYESVPLPKEALNIGTVIAPSQQISFVYKLKEKREKLNLSELQDQEKSNLNSQNEENSLFFNFQEQEIDLIHETESESISESVTKSQTESDIESETESDIESETESDLDKEKTKINVIENENENEINENENENEKTEPKIIKTSENNQSISNRSSNTSNENWCIIDLTKDMSFSEKSGEETINHQKRINFDKSQQDQEPQTYQNLENLDGTPNSKKVAKRFISDQNIPKSKMITKKLFGFDNQVFESEILDSNSEKNLEDKPKTLKGLSQFYIYFKKAQLEQVAKQENSPPDILEFFSYPLNLFQSKTPRKVICSIYRPVSFNFGEDFSIKVILSTNNQNSIDKKFCLELNADFSEWLIAGKTKYFFTFQRKLSHTLFWKIVPLKSGVVRFPQISIIGCQSKEIKFKHYDIQTQNEISKCNGFLNIFPPKIEFSEMTKTNYFSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7M9</accession>
    <name>A0A9Q0R7M9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7M9"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="479"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="593" mass="69347" checksum="774E25F96116185B" modified="2023-09-13" version="1">MNEIIFFGRNQFPKLFKNESNKITKPIQFKFENENENEKQIKQISSGNFSTIFLFKNGKAIEYLNEKDSKQNPSKIQIEENIQKVTAGYRNKAILTKEGNVFAKGEDINPKNTNEFINISSLIEDKNDRIIQDIVSGDSSIYLLTSNQNAYGIGSNDYGQFGFDSEIIKKTEKPILMMKNVSKIFSGNTSQHVFLLNSNQELFGCGYNEFGQLGLGESRKETEIQKLIKIQNIPKGKIIDIQCGFYHSIILIENQNENPKRKLYSCGYYRYNGLGQNQNTYKFTEIKSSLFENDDNILDFSIGNAHTLILTSKGKLIGFGWNEYGQLGTGDTKKQSIPIQIELPKLKFYVSNYRVLCGFNKSFLYYSPPSFSNLEEDLIKLFRRKEFCDISFKTENGEIISAHKLILKYRLNQNQNEKLQEIISKRSIKESNQIFEMIYSNNSKINPILYSEIKEIISSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILTMRSELYRGMFLSVTEDTSNKVTDYSELSEESFQILEYWIYSNQIKDGIEITQEIITELKQKIDYFQLNQTYPNLFHLLLRKFRKDQRQKKKLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7R4</accession>
    <name>A0A9Q0R7R4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000096">
        <property type="protein sequence ID" value="KAJ5070377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7R4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="394" mass="46825" checksum="DD1EC1ED5E3C696E" modified="2023-09-13" version="1">MSFLDPQFIKAVNIFTSRMKKRKQTKNTEEKTLIKKEEEDEVKKQKKRSKLRKNKKITEMKEIKEIKEEQKKITEITEIKEIKEVKNVEQAKKEKEEQKTTNKIFLNNKKQTKRKKKKRNALQCCLCNSTSTSQWRHFPQWATEKKTGEWICNKCYASLRSARRKATEDTNQVFEDQNSDPSDQLNPSQKNSPINEDLQIKNIFTPFNNQKIIDNESIQKDNQKIINNESIQKDNEKIINNESIQKDNQKIILTNFSKHQIHQIPQNILKQILQNVPFLHFSFVSESVSQKKLLPFESFQIFDQTKFQKQKNTLQSFRFYLIGSDSWKKDWGKIIQNSKGTIIEKNQLVSNDFFLVEKEKEKEKEKEIKDLELKGIQKVSIEEVFKVLVDIEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7X3</accession>
    <name>A0A9Q0R7X3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7X3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="378" mass="41305" checksum="E76D5039E433F41F" modified="2023-09-13" version="1">MLIQVLLQKISKNCSSNLTKDATYLTPQFKKPSVILIDEQDDIAYIGFSTEGNIVISRFDLLEFKVSDSIYASTINAAIVSGHLDKENGFLYFGTDSETLTVIKVDFVNFEIVEEKSLITLPNSHLATSVFDVANDMIYFGVNDDNDTYVIKVSSPDLSVQSNISYNDSQISQGAIDVSHGFMYFLLSDSVGGSSFAKIQISNFAPISNVSITQTSIKSLVLDSQHEVLFCGTYSIVEGYGVSDSAVCQVDLSDFSFRTCIGINDTNGFPTGFLEPSGSFVYFASDDSPIQIFKFSSSSLEVIENITLTSGNDFAWSSAADTSTGFVYIGTDQEPTRLVKIQAFTPPDPTPSPPPSSSNQIVFSILFFGFLVLLNFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8G1</accession>
    <name>A0A9Q0R8G1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8G1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="373"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="512"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="68625" checksum="0BDCE867CA2C77AF" modified="2023-09-13" version="1">MNDCLFFGSNKLPKLIKNEPYEITKPIQFKFENEFEFENEKQIKQISSGIFSTIFLFENGKAIKYLKDSKPNPSEIQIENIQKVTVGYRNAAILTSEGNVFAKGRNINPDNSNKFINISPLIEDTNDRIIEDIVSGYSSIYLLTSNQNVYGIGSNLSNQLGLDSKTLKKTEKPILMMKNVSKIFSGTSTSAFLLNSNQELFGCGFNRYGRLGLETKETKIQKLTKIQNIPKGKIIDIQSGYSHSIMLIENEDENQNPKRKLYSCGNYQYNGLGKDGHIYEFTEIKSSLFENDDILDFSVGESHNLILTSKSKLIVFGNNDYGQLGTGNTNNQLIPIQIELPELRFNEDIFNYHISCGFNYKDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQIENQIEKLQEIISKKSTKESNQIFEMIYSNNSKINPKLYSEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILITRSELYRGMFLSVTEDKSNKVTDYSELNFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8Q3</accession>
    <name>A0A9Q0R8Q3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8Q3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="66"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="236"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="343" mass="40849" checksum="EFCFFF258F638549" modified="2023-09-13" version="1">MLIENENENENPKRKLYSCGYYEYNGLGKNENTYEFTEIKSSLFENDNILEFSVGREHNLILTSKGKLIVFGSNFCGELGTGNTKDEPIPIQIELPKLRFNEDISNYHISCGDYKSFLYYSLPSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLKQNQNEIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIEELQIGIDYFQLNQTNPNLFDLLINQNKFKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8Q5</accession>
    <name>A0A9Q0R8Q5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myosin ib</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8Q5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="103" mass="12096" checksum="F3B6B1F8468D49CF" modified="2023-09-13" version="1">MIQFDSIVMLQTKMKQHIIYCIRANNSKKLNSFESKYVQQQVDSMQLVPLKSPKHFINDYGIISNQTWPEFRGELQLGVKIILQKLEANEKDYEIGESDLLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8W6</accession>
    <name>A0A9Q0R8W6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_01809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8W6"/>
    <dbReference type="OMA" id="TPPPWWI"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040469459" description="Phosphate transporter" evidence="8">
        <location>
            <begin position="20"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5070828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="574" mass="63937" checksum="157536505B36C6B8" modified="2023-09-13" version="1">MGVLLFFLIFGAICAFLMAFGIGMNDAANSFGTAVGSKALTIKKALSIGSLFELVGALLIGGFVSQTLRKGIVDPAYFENDQLEFALGMLSALFGSTAWLFLATYWALPVSTTHSIVGGILGFALYKDGTKAVNSTSLINIILSWVISPVSGFVVSWLMFKIMNKTIFNKKNDEECQKASKKWTPIHFGFTIAVMVLFFFESVVKSLKIKLAVWLLIVIFIVSWLISWFICYKWILNFYLKKEEKISDDSFNIVDPLNEFGMLDSFEIFGDIDLHLEKYVEYNVESDELEKEEFHYVIQPEFLPEIPINDRGWKTMSEDSFLTEFSDKMDVNNLRMNLEKIDLNLKSNNQKQSDSDSEIELENTNKFIELKNVDRDQENKLTKKPSDLKEQEDESPYKKEIQKLGKTVPLFMLLQIITSLFVAFGHGGNNVPNATAPFGSIMAVYKSGTTTQVNVSYWILALGGAALSLGLLFFGSRVLLTVGEKITLLTPAGGYIAQLSTALTTVVCSRLGMPISTTHILIGAVMGYGVSLYGWKTGINGKMIFKIIVSWLVTLPIAGFTAIMIFAILRPLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA20</accession>
    <name>A0A9Q0RA20_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cleavage stimulation factor 3' pre-RNA subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA20"/>
    <dbReference type="OMA" id="CEYNDGA"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="362" mass="41532" checksum="28ED8EBDCD3835B5" modified="2023-09-13" version="1">MIKNYSRFILVSNISTETTEEELKQIFSERVGPVRSFHLVFDKSGRSKGMGYCEFHDPETANSAIRNLTHLEIKKRVLKLEHVTNDNIHEIEDSRSLNPFLEQNDPNDKKIPQLNPNIPPKISNPLNGQNIPFFPNNIPPNFQKPDQISQGPDNGIEAIVSTISSMTIEEICSIMIEMKQLIQQNLEQANKLLVRYPQLAHGLFHAQLILGTINPNILPTLNKPQFSEINQPLNIPNPLMHFPLNPTNPVLPPYFNPMIQNPNQNPNQNLIQNPIQNPNQNLIQNLNQNPIQNPIQNLNQNSIQNSIQNLNQNPINENDPQNAEFQWLISKLKSLTSEEFEKLNDEQKSKIQTLIQLYQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAM4</accession>
    <name>A0A9Q0RAM4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAM4"/>
    <dbReference type="OMA" id="RRNHSFW"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061118">
        <property type="term" value="P:regulation of positive chemotaxis to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001763">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="196" mass="22107" checksum="670EBCA2AF87B49B" modified="2023-09-13" version="1">MEDKCKIVIVGGGSVGKTCITLRYLNNKFITHYDPTIEESYRKMTILDGKPILLEILDTAGQDEFRSVRDKYLRTGEGFVIVYSITSADSLWEAQSFHEAIEKVKDTTDTPSLTVGNKSDLESQRQVSTSEGQELAQKFRSQFLEVSAKSGKNIEQVFETIARDVRNWKAKKSGKNQSNKRNSSAISKKKKNCEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB03</accession>
    <name>A0A9Q0RB03_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Heat shock protein 81-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB03"/>
    <dbReference type="OMA" id="TRMKAEQ"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="724"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="869" mass="100131" checksum="FB29D2FD535FA005" modified="2023-09-13" version="1">MAEPETFKFEAEINQLLSLIINTFYSNKEVALRELISNSSDALDKIRYKGLKDKTQLEGAPELFIHLLPDKENNTLTIQDTGIGMTKDELVANLGTIARSGTKSFMEALTAGADISMIGQFGVGFYSAFLIADKVTVISKHNDDQQYIWESSAGGTFTITPDNGEPLGRGTKIILHLKDDQLEFLEESKIKNIVKKHSEFISYPISLWKEEEKETEISDDEDEDEKKEEDEKKDEDEKKDEDEKKDEDEKKDEDEKKEEDEKKDEDEKKDEDDQTDQPKVEEIDEEKENEKKEKKKKKIKTVTHDWELLNKQKPIWTRKPDEITKEEYASFYKTISNDWDEHMAVKHFSIEGSLEFTAILFVPKRAPFDLFEPRKKMNNIKLYVRRVFITDEAKDIIPEYLNFVKGIVDSEDLPLNISRETLQQNKIMRVIKKNLIKKSIELFNDISENKEDFKKFYESFGKNIKLGIHEDSENRDKLAELLRYNSTKSKDELTSLKDYVTRMKDGQKSIYYITGESKETVEKSPFLEKMRKKDIEVLFLTEPIDEYCVTQLKEYEKKKLINITKEGLDLEETEEEKKKAEELKQQNEALCKFMKDALGDKVEKVVVGKLLTDTPCILVTGEFGWSANMERIMKAQALRDSTMSTYMVSKKTLEINPEHSIISELRTKVDKDSSDKHAKELVVLLFESALLYSGFSLDDPSGFAKRIHNMIAVGLGVQNDGPTLDLDQELPKLETQDEVEKIEDEKDEKEKKETEDDMDMENDDCNQYENCTDCLTKPDQKGDCIWCENNSICQTSTNFCPNNITNSTNCPTPTPSPSTSPSTSPSTSPSTSPSTLIHLLIHHLHHLLIHLLIHHLIHLLILPLIFLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB83</accession>
    <name>A0A9Q0RB83_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB83"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24681" checksum="932E803AD838D189" modified="2023-09-13" version="1">MSFIIYAQTPQNCAVAFKDENGNYHNYDFSSLMRTKTEDPYILSDSEQKIIFLFNICANITNILDCYCCVPDLTTGYVISGANLSTCTDFGYLKNYAYQQITQGDLEDGISLIYTIGVEPNIEKFMQINFFCNNYETFRVVTAYYHDTDTVLNIEIDTLTKLTCFSSTPSPIIESCSKCNAAGASFGVIASLFFGVFTGFYFYKWRKNDPISNYQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBV4</accession>
    <name>A0A9Q0RBV4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyadenylate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBV4"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="199"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="383"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="606" mass="72060" checksum="FAFD2F428F833C9D" modified="2023-09-13" version="1">MNNQNQLIKSQNQIEEKGMKYLTLHVSNLPENVTDSTLLYLFTSFNAISAKVAKGINGKSKRYGYVNFSNSKDAKQARQNYDGGEYQQKILRITPKIPFHELKSNRNNVIVKGLKKDWFEVDLREILSKKISYCDIISIKVPRTQTGESKGYGMVNFSTEEQAKEAIKLTGEVIDGQTIEVERYQNSEIRDDQSKNNYKRIYIKKFPENYTQEDLLNLFQQFGNIDKIEISKFGNAQISHAFIDFSKHKEAVLAIEKMNGKKIGIQEIYVGRAMKKAERKRFLQNSLTKKQFLHQNNTIQFQFSEVEQVKDFDSVKLREECLKIEPKPQIFQSKMYYNKDSGRPETGFVTFENIQDFKRVFNYFESNPPSYYQVKKFEKFEIKNEKQIEKQNLNLNLNLNQNQNQNQIENQNQNQNQNQNQNQNQNQIENLNQNLYDYPLYPYPSYPYPYPYPSYPYPPYPYPYPSYPYPPYPYQDLDKNQNSNQNLYSDQNQNSYQNQNSYLNQNSYLDQNSYLDQNSNQNINQNQNLYLNQNINQNSYLNKNQIQNQNLYLNQNINQNQKRNQIQIQNQNLNQKRNQNQNQFKFDKFMKDLDQISKQKKENKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCK7</accession>
    <name>A0A9Q0RCK7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid--coa ligase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCK7"/>
    <dbReference type="OMA" id="WYHSIGL"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="70"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5073814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="657" mass="74856" checksum="4DB04840D52907C8" modified="2023-09-13" version="1">MKQAIKKYHLKENVFSFLYDEKEKVYRNLTCKEKGLATYPEPHLKTIYAILENSLSKYSNKKLYGTRRKEKEKENLGSYEWITYKEFGELRTWLGSAFRGFGLKKGNTVGIYSKNCTEWKVTEDACYAYSLVSVALYDTLGAESSKFIISHSDMQLVVCSSDKISKITQFSSQCPSLKIIVSIDEVPLDVKKTAEDLGLTIKLFSEMIEFGKQNELPHEPPSTDDLASLIYTSGTTDLPKGVIMTHKNLVAGMVGGAWSSEYKLEAEEEIYMSYLPLAHILERSLQNFMVYYGGQVGFFGGDIRKLSQDIEELKPTLLPGVPRVFSRIYDHIMNTIESGGIFQKFMFDQAYKYKLKAIKEGHDTPIWNKLVFDKIKKRLGGRIRVMVTGSAPLSPKHHEFLRVCISDAVIQGWGMSETGASGSLGSVDFFSVGNCGVISPCNEIKLIDVPEMGYISNQTNQVGEILIRGDNVFQGYYKDPEKTNEAITSDRWFKTGDIGKWNSDGTLSIIDRKKNIFKLAQGEYLSADFLEIVYMKTKSISQIFVYGSSFENYLVAVVVPNFDVIQKYLDENSITKTDHQEICNLQQVKNKVLEEIEQVAKENKLKGFEFIKNIHLEHDPFTIENGLLTDTQKLKRFKKKKKKKKKKKKEKAKKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCR0</accession>
    <name>A0A9Q0RCR0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA-processing factor 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCR0"/>
    <dbReference type="OMA" id="IISWANL"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="570" mass="68316" checksum="A23A318CCF416E3B" modified="2023-09-13" version="1">MENQEDEFQKFMTFLQAHPYDFTRWTQFLVFVEKQKIISNIRTAFDFFLQLFPLTFGYWNKYAELDPENNHDIYERAIKAVPYSVEIWGFYCTFATENLPIQSTRKIFERAIETVGINFLSYGLWNQFINWEIQQEEFEFASKLYQKVIRIPIQQLEHIWESYRAYAHTRPIDELANDEEIREIDEILKEDYRLNNVKRSKAEIDVFRMRALLEKQEKIFKKTLSKVNQIGYYESGIKRFFFHVKPLEQTQLTKWEQYLNFAEEEFEKKEESIEFVIQIYERCLLPTALYPIFWIRYARFLEQNSRIADTREVYTRATQIFLRDKPQAFLEYAEFEERQKEFLTSRSVYNQLLTNIAPFHLETITKFAEFERRMFGTPFSIQAENEEDVVVPIYENSLKDFSTRQVTRIPAKSKLPETLLAIELCRYLNRRILFYFSKQNPEMANKLLEKARRLMESQIANHGDNIDLWMTLIDFEIKVGGVETFSRLKTIFETGLSQACPLSNENKHLLLTLSLDLARVYSGDINEIFQIQKRLISNPFSVSTFQELEKNKTRLNLQQNMINQKQAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD47</accession>
    <name>A0A9Q0RD47_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vhs domain containing protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD47"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="319" mass="37902" checksum="EB50E0DE11356585" modified="2023-09-13" version="1">MVSEITEPKKPRLTQEEIKLQNQITVAKELANVFRETLEYTNPKENLQKNQLVQELLAKCQIVKNRMPRVIEKVSSNDKLLEFALQQNDAINNVLQLYQDYLQGKRPEKQEKQEKQEKKNQKQEQKEKNPKKNQKQEQKKPKQISLIDDLIDFNINPNTKLESPIVTKNKEKMKHHHTTSGDNLLDDFEFLSNDSTNLPQDENIQKIPQKKPKKKIQKAPQGFEQVFSPEIERKPVKPVNQIKPPKLQIPENQNQNQNQNQNPEKEEKKEEKKEEKADPDDEFESFFRKRSKLRFHQDKLVSKKKQEEFKKTEDDFFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDF2</accession>
    <name>A0A9Q0RDF2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDF2"/>
    <dbReference type="OMA" id="HYANTME"/>
    <dbReference type="OrthoDB" id="27234at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="2">
        <location>
            <begin position="323"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="675" mass="79735" checksum="7A99FD3C940F0C63" modified="2023-09-13" version="1">MVVYLFLRDFCSCFAFTITFLIIFIYPTLTTIKKIDLENLEYKSNIKNETGFDNKTEKLFWFIHISDTHLNKFHPETIEKFEYFVSEFIPKINPSFNILEKYNLSSPQKWLDIRGNHDSAEIYDLYDPNNFYYRYSSLTEYLNQTQRNPVNQFLFSFDFGQYQFISLDVNPYPHISSPLSFLSFVNESMLQKLESFLNQTQANQTILFMHHPTFLHQYYPKEFLQFPLIAQNNSIRHLSSKYSILALLNGHVHRKGMYSRLSKNQNSKETLELEVADFGKKNIFRIFAIDNDVFSFEDFDINDIDFSSQSITSQKSNEKKPKQKALIVVTNPKNARFITYNEPLNLIKKSQYIRVLIFPNNWDNVASVSCYIDGKKNPLEMKQVEKNHPLFVTKWDPQLCCDKGLHNLNIVVKNSNGEIIAEKSHYFSIDGTVKQIKPTYWNVIQKNELYQLVWSWLLFFFFLFVVGLGLVPQIVKFILKKIQIYDKFNQKMSQTIFEKPSFKSYLLLPFNHLIFNIWKYSLIPFKDFIFNFLSGIFLLFGPVSIGKMIGEDFGIAFLWGCYIDSYFIPYSLPAYHALVIISFVYFPSINTQAFASLYHLIQKKNKLYKWISLFLLLVSFFSIVMFLMIFTFVYYRGYFIIGVLTSFSLFWSSLLCLILDFRSLLKIYFSKSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF42</accession>
    <name>A0A9Q0RF42_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar protein of 40 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF42"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043489">
        <property type="term" value="P:RNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15838">
        <property type="entry name" value="NUCLEOLAR PROTEIN OF 40 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15838:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="198"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="505" mass="59899" checksum="559E57F0DCDBD446" modified="2023-09-13" version="1">MQQLKFISLISKVCTELENNVGIKQKFVAEFIVEIWENSKTLEEFKQNLKEKQAEFPENFVTNIYNIISRLHPNAKKKENLKENLKENLKEKENLKENDVILNKNDSTLDQINLKENEHKPHSHHSHSHHSHSHHHSHSHHHNDHNHYKENNSRHRNTQNRWDQKEKIEKKIEEEDEVKKNAHFYNEREAIDEEPIQYKIYSGEVTGIRDFGCFVRLDGVRGKREGLCHITQMKKTGRVLDPHEIVHKKQRVFVKVLAYAGSKISLSMKEADQSNGEDLFPREIVDSEKKTSLYDPLRSNPTRPNDLNEGAMALSMYAFNKENQNEFYLFQEFILNLKFKLNLKILLKFIFILIKTKIGKKKQTVIKHKNFYYIIIILLLLYYYHYITTKYRNCIIFFYSQTKTIRQEKKHTKRDLPTPERWIQKQLESAGVLDIREQTNYNEETGVLDLDMEDEMEEDLEIELNDEEPTFLRGQTRHTMALSPIKILKNPDGSLVRAAMTQVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF59</accession>
    <name>A0A9Q0RF59_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ada2a-containing complex component 3 isoform d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF59"/>
    <dbReference type="OrthoDB" id="3246549at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="7">
        <location>
            <begin position="507"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="948"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1191" mass="139274" checksum="A4FFDD2E968A412F" modified="2023-09-13" version="1">MTTSRRKTRTLIRTRSQESMEFTTTPMFWEACLEDDSEVIPTLLIPTLAKSYLIRSKTETGDTGIHYCCFKQGKQVESLKVLMSYHMNQNNKNNFGWSPLHISCIQGLHNHCEELLSNGADPDSVNNLGLSPIHYACKYGHSQCLNVLLKYNAKLNKLPDNETLLMLAAKHGNTEIIEILTKIGESVSEKRTDGQNAFHYAIKNGNLQSCSALLKAGADINSQDHSGYSSLHHAVKIGSFEITEFLIQNGASVNIRLNSGDSPLHCAVRNKHFLITKLLLDSGANPNFRDSKGRVTINYSIFFLIRNANPYIKDRKGRDPLKYTKIKKHYEFLFVVLDLALINIVFYRKNEYVSQLIDDGASVDGQNFQQYINKLEETIKTQQETISETDLRKELKKELSYLNNMYSSPMIASVSGKNYEAFRILLNKFAEMKQNDYFTGHSALHKAVLNNDAHFVKILLEHNASVTVTDHDNQTPLDIIRTKNFVKCQQVIEHSQLLHVRYLPRQKFPKIVHGTLEKLLERLLTETLFEYQFCLYFLLMFRFFQKKKEMLNKLIWIFENAEEYISNIAHFESNTNEDKIKFLRVRIAIVLETWIYELFTDFHKNKPCRNPSKSRLNSELISKLSFFDPENYEEQLLKIQEWYLKNLKPKNEVMFTKESLNHLFTSETDEKAQAFSQSPKVQRKLEKANSDKKKLSSEKKLQKQLRKISQKEPTTLSNLAQIFQESSPQSQQRTSRVTRIKSTVSISDLINPDILSEMPEEPTVNTKSTKNSTHFVAKTWTRNSLKRWGSQPENIGRNRARFDPRKTFNILLEFITRNAEKFSSEMIPLKYALTEQLSYYTQKYIKEPLTKIANTTNPSWFDPWRADRKAQAIITDDIRANNAGMMYLFVEVDGMIYARHKPWRATWISDPFDNPQIQSILERPIPESVIKKQKKSKKHVHDVILDNDPLEIARQLTLLEFSYFDKIPMLEIKNWTNGRGLTTEQLKESKVLFKNLPNMIVFDEHYNKIVNFVIFQIVKTVNLKKRLRMLSRLIQVSYHLRKLNNYSSLMEILEGFNQEPVLRLKKTWSKLEKSSKQILMNLKKELRELELESQYRNHYKELLPPCIPYIDHFMNDIEEMDKTFVDIDQDQRIQFEKFVNQFKLIETITKFQRFNFRFNPIQSIQTLIENSPFCSNEKLIEMSLICEKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFH4</accession>
    <name>A0A9Q0RFH4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFH4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="489"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="652" mass="76204" checksum="FD0B759189EA3742" modified="2023-09-13" version="1">MNEILFFGLNQYPKLFKNEPDLITKPIQFKFKNENENEKQIKQISSGSYSTIFLFKNGKAIEYLNDLNQNPEKIQIEENIQKVTVGWQNEAILTKEGNVFAKGKYISPINPNKFINISSLIEDTNDRIIEDIVSGAQSIYLLTSNQNAYRIGSNKFRKIVVWKSTKKVKRIQKPILMMKNVSKIFSGISSYHVFLLNSNQELFGCGNNQYNQLGLGKSRRKTIQKLTKIQNIPKGKIIDIKCGNYHSIMLIENENENENPKRKLYSCGDYLNNGLGKNEDTYEFTEIKSSLFENDDNILDFSVGYYHTLILTSNSKLIGFGDNLFGQLGTGDTNDQSIPIQIELPKLRFNENISSYHISCGNQKSFLYYSPFSFSNLEEDLIKLFRRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNEIEKLKEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRVYLNENENENENENEKDFIIERNEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQLFEYWIYSNQIKDEIKITQEIIDEIKIGIDYFQLNQTNPNLFDLLINKFNNQNQNQNQNQNQNQNSKPKPKYKSKSKYKSKLKYKSKLKLNLNLKSKSKSKSKSKSKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFM5</accession>
    <name>A0A9Q0RFM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase brsk2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFM5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5076889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="663" mass="77304" checksum="A3AB93C64FA6255E" modified="2023-09-13" version="1">MIGNYIIGKTLGEGSSGKVKLGTHKQTGEEVAIKILSKKKMKTNGSYAKKIAREIAILRLLDHPHVLKLYDVFETSKNLYLIMEHLNYGDLFGYLSKRSSLTNEEALSFFQQIIWGLDYCHNHFVCHRDLKPENLLLSDNYNVKIADFGLARMTCENNLLKTSCGSPHYISPEIAKGMLYEGRSSDVWSCGIILYVLLSGNLPFTDINIQRLLEKITIGKFTTPSFFTFEQKDLINKMLTVDPQKRITIPEIKKHPWFTSNLPKNYRQPESSISLKNIQLKIDVDHIDNKIFSHLQSLGFHNPVNLRYSLTNEEMNLQKVLYYLFKKKMRFRDEKLKSNNKSKEKVESELDLELNLNLNLNEKSNLDEKFNQNLNDLNDFNDLNDWWKLNPKPNQSAPPKIPEDDFQVLHENLIFTNTEDNLTKKENTDPIPDTEWIDITLGFQQEIPSDSKIHNFKKSSPIEIKTSKTTKAKKNQKNHKSKQIEKQTSKTPQFHRIGLYSLEENCTKSSRSPKKSWFGSWFSKSKEKQKNLTQKKTNIQLDPKPITKSTENQLTFTRFSPPESSSSSLHYKIQMPHFLLLSKLQSYLDSLHFNYSHPNEFIIRVNNKNIIFTIQIDQNSNCKNRSLVLEHIFHVRLKFGDVDYFNQIWKEIENEIKLKMKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFQ0</accession>
    <name>A0A9Q0RFQ0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Speckle-type poz protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFQ0"/>
    <dbReference type="OrthoDB" id="5560627at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10429" checksum="BEF7B8795A8ADCAA" modified="2023-09-13" version="1">MDNDNNNQIQNANQNQNENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLFYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFY9</accession>
    <name>A0A9Q0RFY9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">M0811_14477</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000031">
        <property type="protein sequence ID" value="KAJ5079496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="392"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="573"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1168"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1202"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1237"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1307"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1346"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1383"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1418"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1453"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1491"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="1526"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="1746"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1011"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1090"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1665"/>
            <end position="1712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAJ5079496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1866" mass="215569" checksum="549CAA188A9D4496" modified="2023-09-13" version="1">MQQLKFISLISKVCTELENNVGIKQKFVAEFIVEIWENSKTLEEFKQNLKEKQAEFPENFVTNIYNIIKKIEKKIEEEDEVKKNAHFYNERETIDEEPIQYKIYSGEVTGIRDFGCFVRLDGVRGKREGLCHITQMKKTGRVLDPHEIVHKKQRVFVKVLAYAGSKISLSMKEADQSNGEDLFPREIVDSEKKTSLYDPLRSNPTRPNDLNEGAMALSMQEKKHTRRDLPTPERWIQKQLESAGVLDIREQTNYNEETGVLDLDMEDEMEEDLEIELNDEEPTFLRGQTRHTMALSPIKILKNPDGSLVRAAMTQVTLAKERKEVREQQRNQMLESIPKDINRPWIDPLPEEGERHLALDLRGLVAYGKKTNLSIKEQRESLPIFKLRNELMSAIRDNQVLICVGETGSGKTTQITQYLAEDGYAKEGRIGCTQPRRVAAMSVAKRVSEEFGCRLGQEVGYSIRFEDFTSNETVIKYMTDGMLLRECLIDPDLTGYSVVMLDEAHERTVHTDVLFGLLKETVKRRPDLKLIVTSATLDAEKFSDFFFECPIFTIPGRNYPVEILYTKEPESDYLDAALITVMQIHLAEPPGDILLFLTGQEEIDTACQILFERVKSLGPKAPELMILPVYSALPSEIQTRIFEPTPKGSRKVVIATNIAETSLTIDGIYYVIDPGFVKQKCYNPRLGMDSLVVTPISQAAARQRAGRAGRTGPGKCFRLYTESAYHNEMFPNTIPEIQRTNLGTTVLTLKALGINDLLHFNFMDPPPTQSLVSAMEQLYMLGALDEEGLLTKLGRQMAEFPLDPPLSKMLISSVSFGCAEEILTIVSMLSVESVFYRPKEKQAQADQKKAKFISPDGDHLTLLNVYESWKRNKFSNPWCFENFIQPRSLRRAQEIRKQILAILDRQKLDVVSCGTATVPIIKSIVSGYFTKAAKKDPQEGYKTLVEGQTVYIHPSSALFQVKPQWVVYHELVLTSKEYMRNVSFIDPKWLVEFAPKFYRIADPTKLTRHIQDNKDNKDIKDNKDNKDIQDIKDNKDIQDNKDNKDIKDNKDNKDNKDIKDIKDNKDNKDIKDNKDNKDIKDIKDIKDNKDIKDNKDNKDIKDNKDNKDNKDIKDIKDIKDIKDIKDIKDIKDIKDNKDNEDIWKMIEENNFQKLKEIESIPKNQLIKEQKPILHFAIEKQVSKEIIQFLISKGVNPNLIDNKGRNPLHIACENENISLEIIKYLISSGIDINSKTNENETVLHYACLNPNISLEIIKYLISSGIDINSKTNYNETALHITCLNPNISLEIIKCLISSGININSKTEYNETALHIACENENKNKNISLEIIKYLISSGIDINSKTKENETALHYACRNENPNISLEIIKYLISSGIDINSKTNQNETALHIACKNPNISLEIIKYLISLGIDINSKTNQNQTFLHYACLNPNISIEIIKYLISSGININSKTNQNETALHIACRNLNQNISIEIIKYLISSGIDINSKTKDKNETALHIACKNKNISLEIIKYLISSGIDINSKTNKNKTALHIACEYQNIQFIKLLMKNDVNIFDLNYDQINEEMINLFPKIYSINEDLNNFLKSSQNENENEKFTDLEIKTKNYFKFKVHKIILLTRFDNDKLILQKFINICNRKPKRDVQLALNFLYTGFTNFDNFIQRFQNFINYQNQMKEIKESNQEEKRKEFENLRKTEIEKENEIEEQENELMKDIFEQIGIESNWIETKKGRKGIIKDLSKLYQQNETKDFTIIIEENENQNQNQNQNQNEKEIKVHKLILIIRSELFKGMFQLNIEDLSNQVHDYSRKSFETINQFIYFLYHDEFEEEKLNENIFEELSDSKDYYQLNPKSLIGELLLDFYYYKNIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGI0</accession>
    <name>A0A9Q0RGI0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein rab-11a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGI0"/>
    <dbReference type="OMA" id="XSITRAY"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001072">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="199" mass="22959" checksum="00AD0156F7639551" modified="2023-09-13" version="1">MEFEEHFDYPFKAILIGNSAVGKTNILSRFHKNEFSLNTQTTIGVEFGSRILEIKGKKIQLKVWDTAGQEIFRSITQSYYRGSNGAFIVYDITNEDSFNELENWIVEFQKNAQESAVPMIIGNKCDLEKDRKIPKEKGEKFAKKNKALFMETSAKDGTNIEEVFQMLATEILNVFENKQQKKDNININNPHSEKRRSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGP7</accession>
    <name>A0A9Q0RGP7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich melanocyte differentiation-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGP7"/>
    <dbReference type="OrthoDB" id="272149at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043313">
        <property type="entry name" value="LRMDA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282">
        <property type="entry name" value="LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="272" mass="31507" checksum="3281F8AE2FA03AE0" modified="2023-09-13" version="1">MKNKDKLFDSDTTSESETSESESTSNSDSESDSDSQKNAKTSGNSKKENKEELSYAFEKGKLTIISQDLEEIPITIIRQFALKTTELNLSHNELNKLDGLEQFTSLKSLVLDNNQISSNTSFPKIRSLETFWINRNQIDNLEKFISAMKISYPNITYLSMLGNPACPNFFTGKDYDDYKRYRIFRLKSFVEETGKKYYRCMTPNCGATLIRFNNQYRFKSFWEFINQMASELGKTSMEIYQLAVERINSEIGEDDHFEIPPAHHVFADYFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGY4</accession>
    <name>A0A9Q0RGY4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clip-associating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000006">
        <property type="protein sequence ID" value="KAJ5080606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGY4"/>
    <dbReference type="OMA" id="HPAYMSA"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="33"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="385"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="931" mass="107761" checksum="58E9CC8AB442E65E" modified="2023-09-13" version="1">MSKHIRVVKKTKSVQKKKKLVDVDWNQVGEKYDPMNFENKENLQKKLDEFYQNLQSNDWETRKHNILQFHKILNGNTITDFSETLIETLGKFKSIFCNLLKEELKGIVKHTCFLISHFARKLEEDFAPIVEDEIFFVLLEILLSTNPVISECADSAIKQVVNKTISIEITSILQEIISKEEDGPLKEFCAEYNRVIIKNYSKEDLSPKVQEIEDSIIILVSSNSEKISVLGRRCFWEFSKHFPQRSKEIFLKLKQNLRSTILAQKHPENNPRNKFFTLIEPLQKSSTQKKKPDPKRSRSLVNKQSVLRLQNKTKLGAFNTKPLNAPTTTLRPSSPKKTVKIQKKVSTKNLLTKTNLGKLTEKKKENPKQKSKILKPTIQKSLKSDSSSGKTVNTKPEKDMKVLITQLNSRDWPTKSNALHQLLEISKQDDRPELTNKKIFKNVITAISRMFADSNSKLKVLSLQVLKELIDNYTLNFDQYLVSILVILIPLNTTKETEKEKITENMDMIRSCFSNSVLIPALTKAYEKIPSNYKPNVVQEMILSLRSNSDNCFEEQNTTKDVILMIKSLLKTKSTKAKPKCKKLLQIILEKNEPDLMKQIKSQNNQTQKLFLPLIEEIKLEKSKLKTKSNSQVKLKQKLKSKSKSISKSKPKLKSKPKSVEIIENINDNENENENDNENDNENENENINENEKEKEKEKENEFREIDLKVQKIILALSNPDQHKESLDQIIQYSESNTEEVWSRSFTTILFHLMNSFLASKSDQNFQQEILTVITKLAKNQLTYFQLCTGDLLREFFRACKGLDEENFAENNRIILSMFPAFEPSQIAFVIKPYLSSNDNHVLLSSITFFGKLSTLISKEQLEEKLNDVYSTLKDYLDHSSPLVRKAVVFTFIDIYKVLGDNFIRNRLAKTLKMGQLKLIVQYIQQEQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH80</accession>
    <name>A0A9Q0RH80_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolases superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH80"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF24">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="701" mass="84858" checksum="22E95F9E8038E4DC" modified="2023-09-13" version="1">MISFEDLVETNSYKKKNETNQETQKTKKKRKKKKKTNKKPNSNQQINENLYIDIDEDSNRNQYQRQIQNQRKNQNQIENENENQNQNQNKNQNQNQNQNKNQNQNQIENQNQNKNQNQNKNQNQNQNQNQIKNQNQNLNQNQNQNQNQRQNQNQNQNQNQNQNQNQNQNQRQNQNQNQNQIKNQNQNQNQNQRQNQNQNQNQNQNQNQNQNQNQNQNQIKNQNQNQNQNQNQIKNQNQNQNQNQRQNQNQNQNQNQNQNQNQNQNQNQRQNQNQNQRQNQNQRQNQNQRQNQRQNQNQNQRQNQNYYQNNRYRRYPNYQHQIISPKEFFMTNEDYQQIIYLYKREFAKMIPLNQDYYNLFIQKYYNKPNYPRPFQPKANYFDFSIDFIWKPPNKNLFPLNPIYLSKWKDANGLFQIKEEELIPNQETVFKEQEILFEIEEIHDILIQIEQSRVGFYFGGPNQQSQYQEMEEALLLKLKKSLHLQTKFVENLLSIPKGKTLLIKILRMVPLFLSNLIISHILYSFISWSSIMNSFGIKNSDFLLCSEIVNIILRNKDHEILDILFESLVKGVYEISQELPQKMHESLQIFPTIWIIHAFLYQLQSKFVSPLNFQSKNIQMLVQLFQGKIEVIIFPLLSKEKECNLFDINQTKIIRFELISLLYFLANSEEKKQISFEINSLISKNSEDDLEIKLHKLINQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI10</accession>
    <name>A0A9Q0RI10_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C/D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000003">
        <property type="protein sequence ID" value="KAJ5080709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI10"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004621">
        <property type="term" value="F:glycosylphosphatidylinositol phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23221">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23221:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040206407" description="Phospholipase C/D domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase C/D" evidence="2">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="355" mass="40622" checksum="D65F7BEBA6F17641" modified="2023-09-13" version="1">MKLHFIFFLIFFLKATLQCGYITHFYISQNAIGESENQVDPTLYNLLSSHLDTVQLGSCTPDWGYNLLINKYHDLSDIIHEEGFLYASFDYLKEKYPDFSDSEAQKYLAYFIGIGGHQTADIYWHGYNGDPLAFMFQVAKNDFDSDSIDGIIHQVMEATADMFIANEHDPHVGLKWWIPAQAVCDVYMRYKEVEVSTTEFIIGMDVLKVLMVLLKTLNWAGTELGKIIEPWSHANYMTWGHGGIDNCVDMSVPYYTDAWLYLNDKQSVVLPHFNYVSYPYSNTGDTSFFENLVPAARELIDSGIISIDHTQNDDGSVTSEIPHIADFSKFLGLIQRYFGISALEHLSYQFLNELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI97</accession>
    <name>A0A9Q0RI97_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_13890</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000005">
        <property type="protein sequence ID" value="KAJ5080638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI97"/>
    <dbReference type="OMA" id="SEWWLMY"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5080638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="232" mass="27229" checksum="26AA6749E8EBD4A0" modified="2023-09-13" version="1">MNSKKTNQKNLTFSNKYLAFYNGIMLIGWSIIFGKGATYFLLGKSPFEIYKLVKMELFIFQTGAILEIIHSLPFISLVSSPLFSTFIQVFSRVFLIWGILNVTEKPKNSPFFISLILAWSPSEIIRYSYYLIRALKKEINIVTWLRYSLFIVLYPIGVVSEIMSIINSLPETREKKIFQIKITESFNFEYSHLCIGIAVSYVMGFSKLYLYMLNQRRKHFKNEKQNQKQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RIU1</accession>
    <name>A0A9Q0RIU1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_14146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RIU1"/>
    <dbReference type="OMA" id="QYKFRPN"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5080129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="166" mass="18905" checksum="1D09CD2C1EF84940" modified="2023-09-13" version="1">MKIFVTVGTTKFTELINIVDSQEFLQLMKKKGVTEITLQTGTEEFEPKELKKETNLTVKTFKLVPSIEEYIEKADLIISHGGAGTIFESLRAKKPLIVVVNDSLMDNHQTELAEKLAEEKHLFYCENSSFLPTIFKNIEIDGLLPLPDTNPDKFNSFIDNHFNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4Y3</accession>
    <name>A0A9Q0L4Y3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4Y3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="720"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="907" mass="108548" checksum="22319555FA228CA8" modified="2023-09-13" version="1">MDNNNDNNQIENANQNENENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRVKTLNLKKYEHKMNAKKRLFHSFFSLFDKDSISKQDFDKLKQFDIFPKSFLIHFERTIFEIQDQEKDKKIKENEKKIKRRDKRIKLFESENENQKQENEKKEKKIKSFESENQNLKQENQKKEKDIQNLKSENEKKIKSFESETQNLKQENQKKEKDIQNLKQENEKKDKIIKQKDEEIQNIKLSFEKEIQNQKEESKQNENKLLKIFSDSEIVKDKEYVKKLQEWINDNDFFSKMKKGFSAKNDGFNSQNWHKTVDDKGKTLVIIKTKDNFIFGGFTRVGWTNDKSKWSEERGNWGWIKDENAFIFSLRNDKGDRKPEQFTIKQGEEKYAIEYDLSDGPTFGEKKIKLFESETQNLKQENQKKEKENQNLKQENQNLKSEIQNQKEESNQKKEKKIKSFESENENQKQENQKKEKKIKLFESENQNLKQENQKKEKDIQNLKSENENQKQENEKKDKILKQKDEEIQNIKLSFEKEIQKEESKQNENKLLKIFSNSEIVKDKEYVKKLQEWINDNDFFSKMKKGFSAKNDGFNSQNWHKAVDDKGKTLVIIKTKDNFIFGGFTKVGWTNDKSKWSEEHDGGNYGYIKDENAFIFSLRNDKGDRIPEKFIIKQGKEEYAIEYDLKDGPTFGSDIYLNSELQSGQSYFGNSYNLPNGITYKTNEAKSYLAGSYNKWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5D2</accession>
    <name>A0A9Q0L5D2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related protein rab-2-a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_03574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5D2"/>
    <dbReference type="OMA" id="CEAIFIA"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5066241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="209" mass="24147" checksum="1B1A3EB8C3E422AB" modified="2023-09-13" version="1">MSAKYNYLFKFVVVGDTGVGKSCILLQYTDHRFQPVHELTIGVEFGARTIKINSETIKLQIWDTAGQESFRSITRSYYRGAAGTLLVYDITRKETFDHLKAWLEEAREHSENLEIMLIGNKKDLKHRREVSYEQGEKFARENNLQFLETSAKENENIEEAFLQISKKIYEKIQNRSNEKDITGVSKRTQTPTRKIDDESYQETSGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6I2</accession>
    <name>A0A9Q0L6I2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase yqhd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6I2"/>
    <dbReference type="OMA" id="DFATHML"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990362">
        <property type="term" value="F:butanol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990002">
        <property type="term" value="F:methylglyoxal reductase (NADPH) (acetol producing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08187">
        <property type="entry name" value="BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044731">
        <property type="entry name" value="BDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE YQHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE YQHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="14"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="197"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="401" mass="45142" checksum="A5B0C31E20578991" modified="2023-09-13" version="1">MSLKSYLNFTFQNPTKIIFGAKTIPQLRELIPGKPKILLTYGGGSIKKNGVYDQVKEALKDFKVLEFSGIPANPVYEHAMEGVKICKKDNIDFLLAVGGGSVIDATKFISIAAKYKYEDPWDMVAKKFNPDPKYHPKESIPLGTVLTLPAAASEMNWSITLSRDSTKQKYFLIDPILFPKFSILDPEATYSLPKNQTINGAVDSFVHTLEHYATTNRNARIPDRIAEGILDTIISETPKALANPRDYAARANLMWSSTMALNGLIAKGVEEDWSTHAIGFEITAMTGADHAKTIAAILPGLWRFKKEQKKEKLAMMAERVYGKKYGTDDEKAYYTIQKTIEFFNSIGMRTTLSSVGIRREHFDEIARRVDYWHKFCDVPPLGEHQDIYAEDIIKILELCDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6P4</accession>
    <name>A0A9Q0L6P4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000130">
        <property type="protein sequence ID" value="KAJ5067311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6P4"/>
    <dbReference type="OMA" id="DVPMSLC"/>
    <dbReference type="OrthoDB" id="5584805at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="190" mass="21892" checksum="B1ACF2CC9D91342C" modified="2023-09-13" version="1">MTQYQTYEKQSEIALTKVKPQLRTGDDWLDLSCFVPPLTTLPSLYVIPRLKEIDLSMNEIKEFPELLYECKGLTYLSLAHNKLTKLPDIGSVFSNLEVLDVSYNELDSVCDFSQMQNLQKIFLSGNKLKDVPMSLCNLKSLKEIHLDHNLLTSIPHQLQSMNLEVFKLEGNQLRSETSNFLQGFFESKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7C9</accession>
    <name>A0A9Q0L7C9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipopolysaccharide-induced tumor necrosis factor-alpha factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_02906</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7C9"/>
    <dbReference type="OMA" id="YTYKRVC"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="8">
        <location>
            <begin position="77"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="18403" checksum="BF461CC0B2155803" modified="2023-09-13" version="1">MAYPYQYQENPNQQGPPFQEPQNFPVVNLPHPQGEMQMQSMDPNFQPNFQQGYQPPMIQQPMMMQQPSPMPMMQPVQQTTIVQAINPKALGMLPTKVTCPHCGHTGMTKVEHVAGGLAWMLCIILCLLGCWLGCCLIPFCVDTFQDAEHKCSACGKMIGRYSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L876</accession>
    <name>A0A9Q0L876_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase rbbp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L876"/>
    <dbReference type="OrthoDB" id="2418555at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="870" mass="103699" checksum="0CD0B94DF5E95D03" modified="2023-09-13" version="1">MSTQNQLSITLLNENSKSIEKAHIFFNLSTINILTKKTSQSIENFKIFQNPKKKKMFQIQILNSSEKLHFKLSSNKDVQNFLTQFKTFKTNQENILQKTSADEIDEIETKKITEKKQLKKESRNELKKESRNELEKESKKESKKESKNELKKESRNKSKKELKNKSRNKSKNKSKNKSRNKSKNKSKKESKKQLEKESKNKSRNKLENKSRNKLEKESKNEKEKKTQFLSSEKYFIGKIFYAKLLNPQFEKLHSAQLRFKQDEFNLITPTQIKRSRYNKKLEFYLDTNFQYRVKIQIKDRDYFFELGTEEEIKDLFLCFSLAKNYYIRKKKKQKEQEELSKTIEVNIKNEDKINLERNEINIKNEDKTNLERNEINIKNEDKRNLERNEINIKNEQKSNLKRKIQHKRIYQDQIVEKLDLDDFVFDSETVSENQDLNEQNDLDYRIFLLDGFFEIIEEVKITISNQKLNFFSKTYYIFEIPLYYLDLFYHTSNSQIVKIRFPDSVSVVVSFPTEEEISQFSELVTNSKKEFEIQKTTKPPQLPVRGDSIQEENLIQEENLIQEENLIQKENLIQEENSIQKENLIQKENLIQEENLIQEENLIQEENLIQKKKSIQKEKKEISKFSPSKSIQNNNSLQNFQILTNQFAVEILNSSFRVIDTGSAIFENDFLILNTSKESYPLNYQKISVKLESIDQRICKLNTQSNGLIILKFVSPKKRFNFYQEINKRNNSKIQKSNSKSNSKSNSKSNSKSKLKLKSSISKRTPIQLEKIHFRKSENEEVPNQQFSIIILNNKLNFQEKANLSVFNEKITLQMKNKEVYSMNFDDLRVFVHPDFIRITRLKTMKHSFLVQFNNEEESQYFHEMIETKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8M4</accession>
    <name>A0A9Q0L8M4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant sh3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8M4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="122"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="477"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="623" mass="74030" checksum="6EC53B2C9BFB1B20" modified="2023-09-13" version="1">MIARRAKKKISKKSSVWLNLDLKWIRKKLRISSGILSYQYAKKTQKIKIDPLTILTTFSSEASKYCCRVIFGLQNEKIEFGSETQKDLDEWIQAIQESQIIEIEKLFPKKKNLSRSLSLDSSQIGSSLVLIKNETEQDKITFEPKYIKFSTTELFIYQEFEGQPEEIVNLIREDTVITRHPDHNLAFEISNEDQNYYIITSSHAEKMKWVQNLNMIIERFKKIEKENDESQKKLFRHLSFKSPSALFFTHAINYEDEDEDKQFKNQTNQTIQKNQKNQENQVIQDIDLEKLDLDDILDDPLLVEQIESDSSVEDESKYSSVIVRAGNDDNQQVYVKEIIKMVQGDSSKSLLNLTKTLKRDQKLNEDDDQTIIYGRRKNTFEHLLTKFYQQENYEENILQDENEQLKQELQEQQDLVQNLNQRNLVLLHKLTSMLEQRENLMFSVSEQNIPFEFCFHQFTNFENKELVKEISYMLEHFADLNNSFQLLSKELNRLEKQDEKLSEEIKTILEQQKQKLETKKEKNISKEELNQLNKQNSDLEMDFYDCLLFQKQNLETNILIIKNYLLILEEQKSHQSEFFAQQIREKNSKLKKRIEGLSALSIKMKEIKTEFEETSPRQKRKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L960</accession>
    <name>A0A9Q0L960_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Proteasome activator complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_03370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5067025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GCQHNEK"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="12">
        <location>
            <begin position="312"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1420"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="11">
        <location>
            <begin position="1946"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1676"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1684"/>
            <end position="1728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5067025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2031" mass="236381" checksum="99B527924E01D945" modified="2023-09-13" version="1">MQYNKQLPYYEQIKDEEDKLLEHIKLGLIQAFCLQDNPKGSSSVISCLSKYLSFGYRPPEKEQSNIIRLLIEFLKVPDIDSHLAQGIIAMLNRLIKKNPEKLVKELKISWRELYNLIVEDSFQKTRAEENDKGIGIPLISFVENARKFFPESSTKEILEEFKPMLCIHDSSLMIGQGFLCLFLPTWNLKNFPIWFDYLLSVWDWEDNVGDWDGVFFGLYSRLIQDSFESLSVIRKQVDQKIQEYLPFFFSKAISIINVPLGSENQIRSKQHQSPMIARILYPEQGNDLLWKERGLAVILVYSWSKKTKEHFRKLMTFLEPYFHPSSTGEWSVSLVGILYFMAECLNKRKLDLHNKKMEIEKIQKKTEISDEEKEYISRFQELEKEDFLTQEECDELNGVIIHLLQQMIYSKSQLIMTFSGLACLKILPISPILIVPKIMDITHMGLATITEIHQTQAAFNLLGSIAISLFSLKVRIGEKGPSYGLLYLQDLLELTLNGIDLNDIPKTFLALLFYRNLFTCVPLIDPSHDDIVDREVYEKWLNEDDSKYPNGKYQEMQIISKQEFLRSNPDLQHLGLPSAKEIFQRTTSGFADWLARFFEKILQILQYLVPNTTQKKRFTTSVSPSQLQLTCNVMLQQCSVPLFKIVLEKLRKFIEDSLIVSTVKQIGYICTSASQAQPEIVLSQFVPMLFNKLFDQTKIEKKEEEIKIKKEEEIKIKKEKEKEIEFDSFLYIPKTLSETELIWFLKIFASIMSTNGLSLLPFRKEIILIIKQYSNHSSKKIYKMAGKIIRNVLKSLTTHYPLEKRSVPPSVWKDPQYRLNHWKLWGVIDTNWVENLEVNWHVPSKEEFEFAEELLSMFLEPTLEEISTDKIINNKAELLKMLSLLRNAVKGSTKYMSEIKAEIFPVKRSSVHPSIINWKKPPVKCGRGANYPQNQWRLRTMEAMHIFCGRVFEQLNEESSVMISIVKILHPLLNIRGLSVAQLVNRKISYRSEKYFSNQISSEKCHPRYFMVERSHTQHIFRTNNIIRNIKYTKPLALLVEDIFKLCTHQYENVRLKIHPVMLKLFSNFPVSTHHILPDFIDILSDQKAKTDAIKGAVSILSDSSILGKIIKNWAFFSRFIISICSSSFNNKEQIQEKISEVFDNFITYFYHAPFMHKHSDIMRRPENKELLDMFPTVPKELFDKADLMHKESNAHNGKIYDQLVRALLKMIKTNPLESQLSSNLRKELSSDKDEDMMIESEDSTHDLSRQAINQQTETVIRSEKLKKQSSLLQLLHTKTTQKQLNWKYIHMITISLLLLSRKDSKPSSKHWHFFIDRINSDIVSARDAGIEALGVVTALFKPKITRKPLNYDPTQFTIYSDITKLDLSQYPKDPTTWLGTRFHDKAWIGWNGDLAPHSRFSFQYDYSIQPTHDPSLDHNFFLAVISDKQFLSPLFSHLATSQVFGEEEFRIHIAQLIKGFTQILRLPFAEVAISETENLLRNRENNASVVTAIEILSGLVRGAKHFNFEETESLWKLVGPLLQQALFVPNLDVFIAFADAIQFMSFDLDPRRLIRLIDILFSNLNSEDEGSIVMTKRLSYIRKFLMEVSWKAPALALQFARFVDKHLFHPSRSVRSVISDCLLVLFSIASQVPRNKNREPSLLFSVQLSPDFQWFIDSILEKLLLQEKFVFQESESKKTQDENQNQNQNQNRNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNDPKNSSKLTETAVKSEMSEEQKKLAIALDYFETIMTWLSLVFWNGYHYQISVLPFINKLIPFVFAVLDRRFGSQPDLVSTAKITLQLISTSSFVSPFVDGISQTAESILNTVISTVATYDDYHIKIAALSFVQVFTFNHFFIISQKTFQEVIKLILNFLVDSQREVRILAGTTLSGLLRLYDLNNIKDLKTEFCKLTNNVHKKIRVRFIKDPQILRLAHGYSIFLSAIVLRDPYSINQQQLDALTELSDLTWNHQEIQNVIKDAFNEFFKTHEMKFLQSKLSKEQLDLLMELKYENQGQTYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9I5</accession>
    <name>A0A9Q0L9I5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9I5"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="79030" checksum="AF9E27D832B239FA" modified="2023-09-13" version="1">MERLDKWIDCVCVLQYQEHNGTKILKKYPNNFQFTKKQKNKLKKISFPDTNRQLFETTYSFKFSKIQHHQKEKENENENENEKEKDKNKQNEIEIEIEENNENEKTAKKIEKLKKKQQKTEKKKSRKIILNQKQKTTLYGFAYYRRTQGTDISRGNEYSIVILTKHLFLGVLKKITEILGSFYFQYGDEAIENGLAEINKWPIIFTPERVYQLPLLGTILPVYFLTPNRAIIVNSKTLVTIPAKNPLRFIEQDRDFSRKFICHTEFPGIEINLYKIFHSCISSLWLLWQLVITGEPILVIAPTPEECNHAVFGLMSLIAPVEYKGVVSQYHIRFGANFDSNFDHRALENDKFYTQAFITATTLDLSSVDLAKFPNQLYITEHDPKHSGKKHFTIKLIHKRRCLISPNKSILKRMKTHKQSFLEQEQESKNQILREHFFQLTRSFTLPLENYFISLMPLGRDVVPFYHPPILKGFCEKEFIGFLLSTEPGRHLEGGEKEGWELIYRKFIRSPNFEAWYQQRREEAIYSIQIYYRNSFLSMNSRDMLAKLTDLQKEDLLKKIDNSILAFAKDKELASKLKIFRQDVMNDLPQQRITEIRRKTFRKLKKKSKDFIDENPEAVFEEIQIPDSINIDDDNNNNNNNNNNNNNNNNDDSQSSEKEFIEDDSDDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAE0</accession>
    <name>A0A9Q0LAE0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab gdp/gtp exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_11961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAPVD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAE0"/>
    <dbReference type="OMA" id="MENYCAT"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04519">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="6">
        <location>
            <begin position="144"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="7">
        <location>
            <begin position="665"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5069061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="809" mass="93723" checksum="761A945459E3EFDC" modified="2023-09-13" version="1">MDSTVSTLQKLQKKLKTKQTKFETEQKLLDQVQKQEAKLVEQLASELVRKTNMMQLLDTFSPDMIRSQISIIKSWEVTTFEFLESPLTFVQTRQYQKMFRLIRQNLSIFANAILNAKKLKKDAIETLSHSAILSVFSHLVNEYEEKLFLNLIKKCFKIRFKECTKDLSRNVISGNKLFARLLSAYSKNVDCDSYLISSLHEPIMGILQSVEIKSFAKNPEIQHNLICKSFVQGLRDKIPLMPLGISWITKLIKDLCEKNHNNDHDDIIGDFLFFRFLNPVIISPGSTLTNIAKTLSQRKQSSIESGISSYLEEVTNVPESYSKSIESIGSHKNGEMQNSSQFAIHKKLVRLRDLFELHKILHEYAIQVKQQNSKLVDNPLIKFLIKIGKPIIVVTEKEKEKYVSLDISPKKRITTDTFESQNQILNKVSGVTKNIDNSKEISNVENEKTKIDPSLLNEIQELLKLCFCSIEDIREEDGDNLTQVLSIQIRKAQLIGSLSLSSLLDCTLNKLKQVPEEIQNSNFEIIIRHSLEDKTSKFKLKGIMKKRHEQESISKLYQTLIDKANAKKRSYHDFIRSLVAHSFISNSSSTLKNMEKKIEECTSLEELKIIAKNFFDTIHHLISTDSLCSFFKNELKDLTRIVQNYLLSSIYINFFYPKFVEKTLETTDSQFSMKIIEIRRYITADFLQIPQKFWEQDLWCLPILELTKINKFSSPLLKVDILTRCAQLVMNILLFQGIKEVGADITLPIMIYIVIIANPPQFPSNIKYIEIFLDKQLLTSTSEYWWTIFRSSYSYLENFNLENLPRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAM2</accession>
    <name>A0A9Q0LAM2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAM2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="256" mass="31399" checksum="E37A19E5C270578F" modified="2023-09-13" version="1">MDNNNNDNQIENANQNENENEMKNLQKKFINQFYLQDLLFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLLQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIKKRNQRLKGKKYEHKMNEKKRLFHSFFSLFDKDSISKQDFDKLKQFQIFLPKSIFIKKQKKLIQDKKNSRKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAM5</accession>
    <name>A0A9Q0LAM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26s protease regulatory subunit s10b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_11720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000105">
        <property type="protein sequence ID" value="KAJ5069377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAM5"/>
    <dbReference type="OMA" id="DHEPCVI"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5069377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="391" mass="44914" checksum="EC3F21291FC03235" modified="2023-09-13" version="1">MNENQRRNQVLERYRKLLIEHERMEDRVKDQRKEVNKQNNEYEKSERDLKNLQSVGQIIGHVLRRLDEDRYIVKSSTGPRYVVGCRNRVDKSELELGTRVALDMMTMTIMRPLPREVDPFVFKMLHEDPGQIKYSDVGGLSSQIRELREVVELPLKNPEIFDRVGILPPKGVLLYGPPGTGKTLLARAVANQIEANFLKVVSSSIVDKYIGESSRMIREMFAYARDHQPCVIFMDEIDAIGGKRYSDGSSSDREIQRTLMELLNQLDGFTKLERVKIIMATNRPDVLDPALLRPGRLDRKIEIPLPNEQGRLEILKIHASVLNKHGEIDYEAVVRLTDGFNGADLRNVCTEAGMFALRDDRDYAIQEDFMKAARKISDVKGLETKLEYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB74</accession>
    <name>A0A9Q0LB74_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Poly [adp-ribose] polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB74"/>
    <dbReference type="OrthoDB" id="348671at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="3">
        <location>
            <begin position="379"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="618" mass="73247" checksum="6E98CEDF9D4A42F6" modified="2023-09-13" version="1">MSGGSWCEFLVKEKWCHKWEHVTSKNYKTHPPRKILCLNMLKNGKCYDVNCPYQHPNPNNKFYEEIIKQVDPYSKLANEKKKNSFFWCDLKMNNKMCRYYAQSKKCKVLGCFFQHHEDPNYVRKDPEFPKQKLIFPIGWKERKEKRLTEQNYKSNSRFTLSQICPNLTKTEGQKMVGCQDPNCSYSHPNPSLLSTNQGMPSNFLENMKKTTCKYYQKTGYCRDKECPYQHLKIKKEKREKNIPQAPQRGDIQIRFHLCPKLIYQKGNTLIGCQDPNCTFSHPNPSLLSTNQGMPSNFLENMNKEFCPFFGEYGQCKKDHCKFQHIHYKEIPEEFSDNQQSPQASFCPFLKQTGYCRLHNVRCYEEKDRERLVCPFSHRVPLNPEIPKREAKLEEIPSKNPIYIDLEKKFLDRWTYGLTPKVIKIEKIKSSYLDYWFTKRKEYLENRRKQSFNISWLYHGTNEKFLEEIYTKGFHILSNYDTNPRCPKSGELAKEKKTPSLCTKKCKFCLTKHCWNRCHMYGLGLYFTYCSSKSDKYIKTDNSIRKMFVCEVVTGNSFMQTQDLPSPDYAHDWVLPPHSYDSILVPGTGKTSTTNVMNNEIIIFHKFQAIPRYLIHYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC12</accession>
    <name>A0A9Q0LC12_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC12"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="76"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5069165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="298" mass="34357" checksum="4EEFE4860D03CCAB" modified="2023-09-13" version="1">MQNLEKFIFRKETLFILFLITSLLIQLNEKKFNRLEKELNDLKKEKEDENLSNLLLKEDKDIKKNQNKITELKGIEAIINPMNKFVDNEKIQENGLGALINIVLNEENQNKITELKGIETIINAINKFPNNKEIQKKGIGTLRNIALNEVLNEKFNRLEKELNDLKKEKEDENLSNLLLKEDKNIKKNQNKITELKGIEAIINPMNKFDNQNKITELKGIETIINPMNNFPNHKEIQANGLRALANIASSNNEENQNKITELKGIETIINAMNNFPNHKEIQANGLRALWNIASNENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCE4</accession>
    <name>A0A9Q0LCE4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCE4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="17734" checksum="55ED69FF2788AFBD" modified="2023-09-13" version="1">MIYSNNSNINPILYSKIKEIINSNEKIEEAIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQILEYWIYSNQIKEDIQITQEIIDELQIGIGYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD20</accession>
    <name>A0A9Q0LD20_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_11173</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD20"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="11">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="12">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5070144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="158" mass="18682" checksum="FE6EBD6208BCDD50" modified="2023-09-13" version="1">MYELHKTEQIYEKNIPNLKHESDGFIFTPVNYGYYPGRFELLLKWKPPELNTADFLFRIDYSKDQSGKTGKLYILSNNQEIPKGELFLDSSIDSKLFDGKIVECSWNPNANSWKLFRYRPDKDLPNGLSTFQRIEKSIRDWITINQLFDYIAKITNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDW8</accession>
    <name>A0A9Q0LDW8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDW8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="106" mass="12866" checksum="D3E1BEFAF41FF218" modified="2023-09-13" version="1">MNNLQIINSLFDLNQQQDAHELFHFLFNSFIRELEIINFQQEKINLKNLMNNFQIINSLFDLNQQQDAHELFHFLFSSFIRELKIVKLELHSRKPQELTYSEINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE39</accession>
    <name>A0A9Q0LE39_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Wd repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_10651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE39"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="243" mass="28705" checksum="0E4977735B8CD6C7" modified="2023-09-13" version="1">MITEEIKQENQNIQEIKQENQKPNQENVQENVQIIIDSTKMITEEIKQENQNIQEIKQENQKPNQENVQENQMITETNNQLNIEKEINPNQMNIEQKPNTEKSKNTPQEEMVSQRRKLLKKGIYLMSKNKAIVYGIRFSPQTGKYLATCAENGEVVIYHVKREVDIDQWPTFIILHGKQESKKKLLSHEKSIQDIAWDPKGKYLFTQDTACVRVWDTSNWECYHIIKSVSQSSFEFSIYNKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEB1</accession>
    <name>A0A9Q0LEB1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEB1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="318" mass="38951" checksum="05D4CEE54BE272F9" modified="2023-09-13" version="1">MRMKNKNFFLFLKYFFFRKIRDWGEIFFSICHLARIKTKPLNGNSFKDFSIFVENKSNPFEIKVHKSILSLRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRNERLKGKKEKHKMNEKKRLFHSFSSLFDKDSISKQDFDKLKQFDIFLSKSFLVDIQNKVIQENQKEIENKEKENQQMKIEIEDKNKENENKWKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LER5</accession>
    <name>A0A9Q0LER5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LER5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="323"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="489"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="584" mass="68140" checksum="95C3DB0D26F678A0" modified="2023-09-13" version="1">MNDCLFFGYNYFPILLINKPYKITKPIQFKFENENENENENEKQIKQISSGYFGTIFLFENGKAIEYLNENDSNQNPEKIQIENIQKITVGDRSESILTKEGNVFAKGRYINPNNSKEFINISLLIEDKNDRIIEDIASGRYSIYLLTLNQNAYGIGSNQDGQIGFDSKTLSKTEKPILMMKNVSKIFSGIASTHVFLLNSNQELFGCGFNQYSQLGLGESREERKIQKLTQIQNIPKGKIIDIQCGEYHSIMLIENEDENQNQNQNPKRKLYSCGSWKYNGLDQNQNTYEFTEIESPLFENDEDILEISVGNSHTLILTSNSKLIGFGYNRYGQLGTGNTEEQLIPIQIELPKLRFNENISNYHISCGVSKSFLYYSPLSFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNEIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVINDTSNKVTDYSELSNKSFQLLEYWIYSNQIKNGIQITQEIIDEIKIGIDYFQLNQNKIQNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFH7</accession>
    <name>A0A9Q0LFH7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box and wd repeat domain-containing 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFH7"/>
    <dbReference type="OMA" id="FHITANI"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042627">
        <property type="entry name" value="FBXW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="241"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="280"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5071887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="456" mass="53396" checksum="307614439494198A" modified="2023-09-13" version="1">MGNSQNNLQDPLFINQNQIQIQIQSQKENQNQNQNQIQMNFEKLPEEIFVYIFQYLNAENLLKMSLVSRYFNQISNDPYIWKCLFQQENPHLLKVLVAPPSLMTWKKYYYFRKNWKRKWYKQKFHITANIRYQAGVNRAKLTGIDGFATCNWDGTIKLWEISKKRKSYTFPLPHTGPVWTIDVNKLGTQLVSGGKDQQIHLYNIPSHKDIQKLYDQEEQNLKKNNDSINPDLNQQLQPQIYEGHHAPIACIKFDEEKILSGSYDADVRIWNKQTKETRSIIHHNDSVWALDYVGDRLITGSRDTALRWWNMTTEKEVDLLVGHESPVSTLQYDGDIIISGGYDNTCRVWDLRSSKRCVDVVQGHQGTVSYLQFDSDILVTCSFDSSIRVWDRRKLSAAPLQVFKEFQKQAWLLSVEFRDGVLLAASNAGEAKVFDFRNKQLLEVENSEMLRKWQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGC3</accession>
    <name>A0A9Q0LGC3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_09783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGC3"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="274" mass="32453" checksum="CBAEFE0312A54795" modified="2023-09-13" version="1">MNLIGIEGGLQIRRTKRFVSSSILPSWRLNYVFFFNLKKKYFFIFHFFIFFLFKLIMKLLLLFLFFFIFLFTYFTNAKSYKMDFEFEHKLGNEWKKRGKIEFISPIPFKKQGTKRIKIKIENYELTEKDKKELIENANKEGYYSIRVPTDPHSKSKASFSIASIKAYDLLRSNGQDQIILHFDNNEKIIGVDYITNFNYDKNASSKSEKYFPIKSLKTTGFIDIPVHGATVNLNQGYGSEFRKMTDQPEEKSFFKKYWFIIIPVLLLVCMGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHL2</accession>
    <name>A0A9Q0LHL2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHL2"/>
    <dbReference type="OrthoDB" id="10651217at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="261"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="427"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="536" mass="62694" checksum="E0BC86A319A078EC" modified="2023-09-13" version="1">MNEILFFGRNHKPILLKNEPKEIKKPIQFKFENENENENENENEKQIKQISSGEFATIFLFENGKAIEYLNDDSNQNPSKIQIEENIQKKEIIIQDIVSGANSIYLLTSNQNAYGIGSNSYSQLGVDSKRLYKTQKPILMMENVSKIFSGNSSNHVFLLNSNQKLFGCGNNSSKQLGLGESRKEETEIRKLTKIQNIPKGKIIDIKTGKLYSCGRYFFNGLGKENENTHEFTEIKSSLFENDDILDFSVGCFHTLILTEKGKMIGFGLNSSFQLGFKDTETQLIPIQIELPKLRFNEDISNYHISCGDYNSFLYYSHPPFSNLEEDLMKLFERKEFCNISFKTENGEIIEAHKLILKYRLNQDENQIEKLQEIISNKSIKESNQIFEMIYSNKIINSKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIKITQEIIDELETGIDYFQLNQTNPNLFDLLIKKFNNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHL9</accession>
    <name>A0A9Q0LHL9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHL9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="677"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="717"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="895"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="983" mass="110973" checksum="CFE6EB612622DEAE" modified="2023-09-13" version="1">MSRNIHFESIQKPNEFLLIKPKFYTLKTTNTEKNSNSTLNTNSTLNSIKNSIKNPNKNSNSNSNLDSNSIKNPDLNSNSNSNPNSTLDSNSNSNSNSIKDSNSNSNSNSTLDSNSNSNSIKNSNSNSNSNSIKNSNKNSNSNPNLDSNSIKNPDLNSNSNSNSNSNLDSNSNSNSIKNPNKNSNSNSNLDSNSIKNPDLNSNSNSNSTLDSNSDLNSNSKSNSNSIKNSNSNSNSIKNPNKNSIKNSIKNSIKNPIKNSIKNSNKNSIKNSIKNSIKNPIKNSNKNLITFHNKKFEQQEEDSSSNEDKSQTEKEMDNYLQKLIEKNKISFEKFGENYKWKEEINQKNLLEETILHFVCRKKTTTEKTLKKLLKLGADPNASNKYYSLTPLHLLCEQTPLDISKLRVLLESGADPNMQKRISKDTAFHLICENSTVNLEIISLFLAHNATVQTLNKYKETPLHMACANSHIDYSCVKCLVESGADLFQKNSDEMTPIQIACKNPKLMNNIVDLLIIHGNQRVKNMKDTRTDLLDPVDLNAKQNEWRKNGKFQDQLKKLILYPLSFPDSQRSAQRNTLLHFACMSFELIPEIVQLLIFSGEDPNAVNSCGNTPLHCACENMNCKISVLGMLTKTYADINKQNECGNTSLHLLCTNENCDLETLKFFLSLKPDTSITNNQGNTALHEICMKYHQNMRVFGVLIKGLLDHGADINQQTKTLLHTPLHIACFSSSHNLIQILLSYGPNFLLLDRTNRKPIDYIVQSDDLGNKIFMQSLSLNFALNSLFVNPVLSDFEFQCKDGTIPLHKSILKARIGKQNNCLRNLIRVGRLQKKSDMIHFLKFVYSGLLCDKENDKYIAKAQIISRIANKIRFPNWWLKRGSISLRKDLSEMFNDQSEKDFSILTSNQKIFAHKIILISRCSYFRKLILNQDSQNDPNSISDLSGKSYLQIEAFIRFLYSDKIDSNLLKDFELDELQKIYGFSYSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHY7</accession>
    <name>A0A9Q0LHY7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional coactivator yorkie</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_09472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHY7"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5072775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="289" mass="34603" checksum="9B66D948A9E85F0A" modified="2023-09-13" version="1">MKAYEKYQAEKERLEREAQELKLQQEREKREREEREERERREREERERREREERERREREQRERREREERERREREKRERKERERREREQREREQKANLPPKMLMTPNLSNVINLGMNMPMNTTGPVNFSMHTSTTSPSLQRNYQTQSTSTSTITNPTTRSQSLGFFNTTKPQTQPQTQTQTQPSMFSGRTGLQQTLSTRLQYLKSAFPTANFNTTQPTRSNSYSPPQTSVNSSPNSQPLPPGWEQRTDSNGRVYFVDHNTKTTSWKDPRQKSSTAFNPSGVFQSTRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI89</accession>
    <name>A0A9Q0LI89_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_08415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI89"/>
    <dbReference type="OMA" id="WHQNDED"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="136"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="371" mass="42764" checksum="75BBE0B986D3CA56" modified="2023-09-13" version="1">MNDSLEEIYELEQSIEEKKICFCSKYLPSRFSVLCEHFVCGWDFYFPLLVALCLFSFATFTFNRMAIGLSNASVKIFYLVVYDLFSLLFLSSYIRTIFTDPGIVPINWPNLDLEQSCPKIPKKVMTDEEHELARLRPRPPRAKYTKRLCALIRKLDHICPWVANAVGFCNYKFFYLMLMYGFLTCLTGAFMIIPILTKPSRSKIGKEFLIPTLIIYGLFFLNIGNLLMHHTFLLLRNMTTLEYLEMSYAKEQGEDYPNIYDLGTFANVKQVLGQKIIVWFIPTGFSVKGDGYSFPTNGLDCPRNELRSVSSLSHPKTSEKTERSYGKISDDEIYNNHSQNQDDPVVQALGIPLTEDSIYIDEQTSQISTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIY8</accession>
    <name>A0A9Q0LIY8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIY8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="390" mass="45844" checksum="CB1A6503D054A272" modified="2023-09-13" version="1">MDNLEINGSISFSDFSDFFESEDEKETGIQTPIQTPLNENLFKLNEENLIKENLNGDNLQNLNEDNLQNLNEDNLQNLIKENLQNLNQENEQSLNQENEQSLDTINSFQQQNNIQKETQTTKEVKKSHQKNKKQTQKKLKRKKHKKHKNKEIKEKKKKSKRRIPTKTEKQILKQLFISNQNPSPSEITEISQKIGWERRRVTRWFSNQKSRIPKGTLLQIEDKNISDLESLLEQHKQLFLKRTSDQLQSTEKVLEFFQAFNLNFNKFAQTFNSLYDQNRKNFEENKQDSEKNNNEKIGIDSKEKKNKDNQNINSNNKNDNQSLIPKSKNLAFESISNQISQENLEIQILFSEIEEVLTKSIFSNQSLFESISFGDDDADNLKEIELTNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJP9</accession>
    <name>A0A9Q0LJP9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26687at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="1402"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1270"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="552"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1273"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1641" mass="194684" checksum="6E8A1A40B76CB1C9" modified="2023-09-13" version="1">MKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENQNENENQNQNQNQNQNQNQNENQNQKSKSKIKIKIKIKMKMKIKIKIKIKIKIKIKIKIKIKFKIKIKIKNQNQNQNQNQNQNQNQNENQNEIKIKIKIKMKIKIKNQNQNQNQNQNQNQNQNQNQNQNENQNQIKNQNQNQNQNENQNENQNQNQNQNENQNQNQIKIKIKIKIKIKNQIQKKNHLVQLIFLCLNDFIKKFISLETIYNSFYEEKDEEKISKLTTIIEDINNKKRSFNPEIFTKSLQLYRICSQSFLSRSNFAKLNLLISKYLEKKPTRTLQNRTTSLSSLITMFEKPKQKESLNESDFSLSKSHSLSPKFQKSTNIEKFFEKKIEEQKIEEQKQLQIKKNQENMKRQQEVKRQQELRKKQEEEEELRKKQEEEDELRKKEEEDELKKKQEEEDELKKIQEEDELKKIKEEDDEKDQKNSQTKKQKKQEKKQKKKEEQKQKKLEKAQQKLQSKQGKKQKDKNTNKKSIDLDKENPNIDENEDQILKEKKILQEKKMLKKKILEEKLKEKLKEKHKESEIETKRRAKSEIVNEAEKLNSKHKKTKSQIESEIESQLGNRLEYQMITKTNSDLAHLKQISIRCPDLSEKITRFNPLLSTAEEVIHNILHSMNKEEEEYNIVFGQQEKESGFIDKIMQKSFRDKINETQTLKYVIISNLQIVPSEAIINQYIVENRMLILQKKFITVNVILQPPQNETIPILEQFTINSKVTSVIKKLSKKYKFQPDVYGLFVVVPSTVFDIDFIRSSYWNSFNTRLVFIHEKTKNQKNEDSISIDRNSSFDEIVFNENSVFQIDEYLEDSMKFGYWLSPQKGVHLSDYLNNILTTETLIIKLQPKPIRVNLTFWNTGKADIITRSIVVDLTIKCGLLIDELCSYLNIPKANMIGHLFYMEFEGEEKKTKKNETLPQEIRQLIPLEKHLNLMDLQIQENSTLRLIVAEREKAEQKYEPIQFNPKSKQQIIFDDLTYFWNEIPHLGEQNLALYSNKEIEQDRATLEADIGNWKSFYSDSKEKDNFMFYFKIKSASLNRILDLLTNEEFYSDIFAKTFIITLPLVVKDEKIFIEKLKERFRFPHQIKINIQERDKVQFYVTQLLKKYVKFKLKNNLQLNEEISNEILRFIRNDLLIHSKADFRTTGCEIELLIMKFYHVSFTLTDFTPTNKPTKMENVAVRQHIRKHSSDLNRTKSLYIRPKEKIKETTTTKSITKILSKPDSSLIRTKSEEKPNKEKQEEKKETDSVVKNFLSQFIPSAQKQKSVQEHLGIWKANSNGKIKDFSLQSVLLAGIAFIDHQAIEEQEFSDYSDLSFYEDDEILSDQPRHTSLDLSTVAYPISPIFSSHSKQIPILKINPSEFCKQLTLKTFNLFKNIKIHEFFFARWTKKNIEKQGKDANLAKNVISMIENFNNIADWVSLSVLKEPQLEKRVKILSVFIKMGYYLYTIGDYHDMVAVVSGLQCSSVYRLTNTWKNLPQKSSQNFQFLDQFASADHFKSLRDSYRKASSATIPYLGVYLSDFTLLDEISPRLKNNLINFVKQRRFYTCYLQIRKFQKTPFNFPFNESIHKIVSAIPTEKVDQQVFWDLSSKIEPLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJQ6</accession>
    <name>A0A9Q0LJQ6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Las1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJQ6"/>
    <dbReference type="OMA" id="EISHRKF"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="54457" checksum="B0398A79A74E5EED" modified="2023-09-13" version="1">MKSIIVPWKNQNEWNQVYSDIFSEQIEKQQKALDQIAGWRFRGKIPHAVDITSLLILTLLKYKNKKYSTELELRLELSTSIIRFVNGLVDSKQKKQHVIPVSNIAKDINLPQFFVEIRHDSTHNNLPSLEVLQNAAYLCLDWLKNRYWDVYQNIVDSLQENIISNLSEMQSKILTFISKQKKEKPLENQKKIFNISGNYFKIIQSFKNDDFDLCSSIVSLFINSEIISVEIMSNYSFSQIVNSWIPFILRLFLDYNHAITQLIMLVVNKLIPFQKVDHPQFKMKKFEIFSEIISKSIDICFDNQLFNKILSIFNFPKENQFCKYLEQSLSGFLEEFLLKIRRYNLNFEKILGSLVRSGILSQEFHDQIKFYWNFQQNSFPNTSFDLISQRESLRQDDLGLEELEKLVSNSNQNQNQNQNQIKNIWSLSTDFPIGLPIGLSPDGYFPNLYLNLDSQLIHPKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK19</accession>
    <name>A0A9Q0LK19_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UBIQUITIN-60S ribosomal protein L40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_00971</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK19"/>
    <dbReference type="OMA" id="CGRCSQL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5074342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="128" mass="14626" checksum="71BD51B6B754F4F8" modified="2023-09-13" version="1">MQIFVKTLTGKTITLEVDPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLNDYNIQKESTLHLVLRLRGGVIDPSLKVLAGKYNCDKKVCRKCYARLPLRAHNCRKKKCGHTNKLRLKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK79</accession>
    <name>A0A9Q0LK79_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK79"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040203344" description="protein disulfide-isomerase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="259" mass="29957" checksum="C20A69D748AD2232" modified="2023-09-13" version="1">MKVFGIFILVIVLISLSETKVVRITSKNIKEVIHNPNADVLVKYYATWCGHCQRLKEPYEKASDAFDDDDDVIFAEVECDGEGKDVCQKASIRGYPTVRFFSKTNKNEPEDYNRERTVESLVGYMNDKCSKFRNPDGSLKAESGRDKEMDNLAQKFIKAKTEEEKQAVIKETQEKVDSLNNFDLYPKIMEKILKNSKYVETESQRLQNLINSGSITPTKKTEFSKKLNFHKKLNIFCFLQDNIGIVKHIFYTYSPCREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKJ5</accession>
    <name>A0A9Q0LKJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U3 small nucleolar ribonucleoprotein mpp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKJ5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="271" mass="32112" checksum="A6E4518799FF144E" modified="2023-09-13" version="1">MSLRNFIVDLFSFCEKQSLTIKEILNNKQLTKQFTDFSNYGIEQLSRIDILITDLLQHIKSNFKICEYQSKKIPREEKYLYQSNQSEKDSSPNIREKSKTNEKDSEKEKDNETESEFEKIEMESDMVESTSETFTEKENEQQNLMSPKEKINIVFDLDWFLYQLIQLLCSVSWQFCTTTYFLQEVIERSINNNSSLWSSEEITTSIKLCIEARKIFWTSAQSFIEKIKMCLMKEGERKALNSNKNFNDFFGSTIFSIENEIKILKPFIEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKP8</accession>
    <name>A0A9Q0LKP8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKP8"/>
    <dbReference type="OMA" id="ADHVQIT"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="59"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="256" mass="30100" checksum="0C6639F970C432E5" modified="2023-09-13" version="1">MEPVNPMLIFKQMDEIKDEIKSKQPLVGSIENLINISQEYKETNPIFEKRIIELSKEFPKVQRMRADGNCFYRGFFYALFLFLIQSNDKDSLTYFQKKFAFFRTKLEKRYGEFIMEMFCDSIDDVLLSIEQKTLDEEKLLDLFNEQMTSESIVAYARFLTSTYISENQSTFSFYVPMGMTVSEYCKQNIEPMEQEADHPEIFSLSSALLDESTGLAIQKIDGKVNENYQTLIFPNQDSNPKFNLLYRPGHYDILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLK9</accession>
    <name>A0A9Q0LLK9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLK9"/>
    <dbReference type="OMA" id="GHDWFHI"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="218" mass="24973" checksum="24D8639184F22752" modified="2023-09-13" version="1">MNAKEFYNSLVSLVSNQLKQNDSAHDLSHSKRVLSVALEISKENGEIDEIVLIASSLLHDICEKVIKESKPKISFKKAKTILENYSQFLNLDQIKKIKDSIVNHSFSVGKIPQTLEGKILQDSDRIDALGASGIARVFAICGERKSSFYHDQDPFCENGRSLDDKNYTVDHFYTKLFKLKDTLHTEKAKEIAEKRIQFMKQYLDQFRSEISLNIEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM24</accession>
    <name>A0A9Q0LM24_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hamartin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM24"/>
    <dbReference type="OMA" id="NNFYWLK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="646"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="811" mass="97291" checksum="7DC5BFB9D1675487" modified="2023-09-13" version="1">MLNQNEFILQIIESIKKEQFQESILNEISKDRSKTQKFISFSKEIPINLKEILKLEKNLKENLINLNENLSKIICYLNYFYQMICKFQYNLLKGNIDEWLNVLKSFIDFKNIQLFKLMKKIFIQLLLKKDYENFHFLFLYYFENDSENVFKIFTKFIKLDSYCFFDQMNQILKHKHYQSFCVNLILKMMVLIEKNQIASIMDTSLFSSLISISKSDKNTLDIISSTWILCIIISTFQNPHLISKHQKDFFQIFQRLIIISNERKTKSQITIDTLKNYIKEFQIQNQNNSFYSKKRNSIQNDDDPFLFINYIEIISNIKKKEQESIKNLKNFQLKNYQNIIHHLHFIHLKKCITELLILLYGYFPKEFIDLIHKEYSSKKSKQRFDLISSFLNNLFVHPKLFDDKFENYEEVIQKIKTHFVQENLNLNLDENENENLNENENLNENENENENENENENLNENLNENQNQIEIDSIEENIKTSQEMILILNNFQQNCQFKIKPSIFQNLKKSLKDIDLIKMEKNQLDIQQLLQENNTLKCSILCLENEVIFHNFLLNNYLILNLKQNSQNNIQIKQENVIENFKATETIQNKIIMETKEQLQFLQKFLSNIILQRNLDEDRLISQNLNKQLKISQSKVFPLEIKIRYLMEKIQKLQSIKEKNKILKANLQISSTMSQFYPLIVEQNKDLENENLFKNQKIKELNSKNLNYESKLFKLQNEIENFEIKISSLQKSNSDFQKKNQELYSSLIKQQSSFQQNIRNIQTKYENVVEDSLRKDRKILELESKLETIQVKLFSTNRESSLLNENENLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMH2</accession>
    <name>A0A9Q0LMH2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5075109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMH2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5075109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="91" mass="10654" checksum="207C19F4E9369802" modified="2023-09-13" version="1">MIWPKYSIEFSSVCCVFSLQKLVKIVLLLYPVDFSNSWRFWYPTDNDILQNSNHPFISHLSHQSFMNFISETKCFSNHLSPTDSSLFLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMX1</accession>
    <name>A0A9Q0LMX1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nad p h oxidoreductase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)H dehydrogenase (quinone) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMX1"/>
    <dbReference type="OMA" id="HGILHYP"/>
    <dbReference type="OrthoDB" id="26889at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051545">
        <property type="entry name" value="NAD(P)H_dehydrogenase_qn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204">
        <property type="entry name" value="NAD P H OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204:SF34">
        <property type="entry name" value="NAD(P)H DEHYDROGENASE [QUINONE] 1 ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like fold" evidence="4">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="240" mass="28262" checksum="4DA7D901672C4DA1" modified="2023-09-13" version="1">MKILIIYAHPEPKSFNNALKEKAKEVLEGNKHEVQISDLYAMKWKAVADKADFTELKDPSFFKMQMEQKEEKMTEDIKAEQKKVEWADMIIFQFPLWWFSCPAILKGWFDRVFSTPWSYSWPKIYDQGSFSKKKALISVTTGGPQPMYQERGLNGNLSKILYPIMHGALYFCGFQVLQPSYWFSPAHSDEARKMYLSQWEERLKNIEKEEPIKFHKMEEYGQTGLPEDKENDFEILGKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNK2</accession>
    <name>A0A9Q0LNK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 13a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNK2"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="381" mass="44694" checksum="FEC87FAE90A4D651" modified="2023-09-13" version="1">MQTVLTSVLNHLLGQFVEHLDSSNLKLGVFKGDVSLNNLKLKVDALNFLKLPIKIKEGFLGEFRLKIPWKNLKNGTILLEINKIYLICSSSNYVNDDDAIEQAYEIKKKLLESYELSQKEKKIKSPGFVDSLVAKIIDNLKVSIKNIHLRYEGAAFRRNFAFGITLDQLNIQSSDKDWNGNTNTRTDTLFKNITFDHLSLYWDTDTDPVVFNSIEEFDRKLDSLIPKKNKEQVYHQYLLRPVGGILKLKMKKFAYALGDSLEEPRFDILAHFETFSFTFEDLQYKMIVHIASLLGRFYRMEKFNIYHKPKAPVRIGMDQVSKEWWKYIYRCGKGIVLEKKGLFNWDTLVTTTQKRKEYVSLWKKKNFKIEKIQEKSRKFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP46</accession>
    <name>A0A9Q0LP46_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP46"/>
    <dbReference type="OMA" id="CENEIGA"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF158">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="62"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="237"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="246"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5076487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="329" mass="39293" checksum="C953288810F75E3F" modified="2023-09-13" version="1">MTQNWKLLQNELKKLNQLKKPLSKEIVKNLKKKSEKSFKNTINTTNTTNLLLQETEDYKIGKIIGLDCEMVGAGKKGRKNILARVSLVNFEANVIYDSFVKPEETIVDYRTPHSGIHPENLENAPNFETVRNRVLEIIENRIIVGHSIFNDLKILKIIHPKRLIRDIAFYPPFKNENGFRRKLKDLAKEYLNIEIQKEEHSSIEDAKSTMLLYKLVRDQWEPKINEMEQEKLERIMKKRKKKTKSKSNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIEKPKRRKTKERILRKKKKQKNRKKFNWYGKPNRKKEESEEFDDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPT8</accession>
    <name>A0A9Q0LPT8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPT8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="400" mass="48042" checksum="2ABD268CF8009FDF" modified="2023-09-13" version="1">MMNYCFMCQAPTSIGHKCPANGFFYCPQCSIKISNNSKCPHCGEKIDFPQEMIQVQQQFIPQDDSRMCPYLQQGWCHDYQHYKTNDQEIHPTNRIVCPKFYKGKSCKSSNCPYNHPRVEDFLEWRNKILSQNPNVEDIKKTNCFFLDQRPKTHKTKCRNEKSSHFSHFEKSCEVKMCGYEHPNFPSKLKSKMDDYNPTYKNQNPNKNKNKNKNNAQNKFTTPFQNQLQNQNLNTNQFPNQNQNQFPNQNQFQNQNQLQNQNQNQIQLQNQNLNINQNQNQFPNQIQNQNQFPNQNQFPNQNQNQNQNQNQNQNQFPNQNLNINQLPNQNQNQNQFPNQNQFQNQFQNQEQNMDYKQKHKHKHKHKHKKEKMNSDQNQNQEQNQNQFPNQNQNQFQNQFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPV5</accession>
    <name>A0A9Q0LPV5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPV5"/>
    <dbReference type="OrthoDB" id="10052614at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040225336" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="172" mass="18624" checksum="2BBA2AC5641BCCE5" modified="2023-09-13" version="1">MKFVFILILLSVLQFVRPRCDCPFMCGAGYDGTEAQCFCFCDQDAGNFPSGSSITCSYFPSGEFSTGGCSLCGPDSTFDEVSQVDSKSGVKVTGITKQNNLRGSVPFPLYVCYCPQECDWGYTGTYDECVSWANSQASRFLNGVEQITYFPWGEFSSGGCSACGHADPCTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ27</accession>
    <name>A0A9Q0LQ27_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ27"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="267"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="491"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="596" mass="69254" checksum="FF2258E2C6F93C22" modified="2023-09-13" version="1">MNEILFFGRNKYPKLIKNKPEDITKPIQFKFENENENENENEKQIKQISTGNYSTIFLFKNGKAIEYLNKNDSKQNPSKIQIENIQKVTVGSDNETILTIEGNVFAKGKDINPNNSKEFINISSLIEDKNDRIIQDIVSGDGSIYLLTSNQNVYGIGLNQYGQLGFDSETLPKTEKPILMMKNVSKIFSGIDSAHIFLLNSNQELFGCGDNSSNQLGLGKSRKKEASIHKLTKIQNIPKGKIIDIQCGSIHSIMLIENEDENQNPKRKLYSCGNYQYNGLGKEDENIYEFTEIKSSLFENDDDNILDFSVGNSHTLILTSNSKLIGFGYNYYGQLGTGDTKNQSILIQIELPKLRFNENISNYHILCGFNKSFFYYSLPSFSNLEEDLIKLFERKEFCDISFKTENGEIIETHKLILKYRLNQNQNEIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQLFEYWIYSNQIKDEIEITQEIIEELERGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ34</accession>
    <name>A0A9Q0LQ34_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ34"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="390" mass="45557" checksum="1ADEEDFE98EC55A7" modified="2023-09-13" version="1">MLIDNLTCQLGFGVACFFFVPGFIWLMVDSVTRLKLEKTQCEIIDKYYVEYTYNSTGGKPTVPPSATPQYRLPNPINSISNSINSNPENSSSSFSPHSISFQNLFGAACITSPTINFVPFFQIKYTTKDGKEYTEYSCNFGKVCWTAKGTGCRVSACDMRISTKICKNFSNLKKSNIYDKYDIGTTDCWYSKAYNDYATIHFPHPNILWSLFFWIPCFISCLPVFGYYNQKIKDCCYCCSKKRSNQDEDDEDDEDDEDDEYDEDDEIEIEIQNQNQNQNQSEEIENENENENENEEIEETIPKLKGDEDFETMIEIYRNQNKNLNQNENENENENYNYEPKENDEIPMEVIQMQINEYNQQEPQTNEQINTGPLYNPYYQNDLNQENKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQF3</accession>
    <name>A0A9Q0LQF3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long chain acyl-coa synthetase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQF3"/>
    <dbReference type="OMA" id="KCPIVEH"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="102"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="677" mass="78586" checksum="159B6D551721C9A3" modified="2023-09-13" version="1">MGITQSKQTEQIIQKTPYSSKRKRIDGYIPEQFPRIVEKEGQKFYSWNYKQNGETIYRSNLAKDGLISKWNESVSTLYENLEVTTKSVPDNQLFGTRKYNKTTKKYEDYEWKTYKEFGEERTYFGSGLINYGIKKDDRIGIFAKNRYEWVLTEHSAYAYSFLLVPLYHTFGIPNILYIINHSECKVVITEMRNISKLKQICEEFKTLKSIIVLDDPEEDIDKFLEENEDIKFLNSHNINIYKFNEIFESGKQKQYPHQPNKPDDLCSLIYTSGTTSQPKGVLVTHKNLISTVAGFYYIGYDFSDNESYYSYLPLSHVYERALENTMIAVSSRIGFSSGDVTKLVEEMQLVKPTVFAGVPRIYSKIYDKVTQGIKKKSIFSQYLFQVAYEAKKKAIENGESYVLWDKLVFNKTKQLLGGKIQFMLSGSAALLPLHQEFFKILFTPHFVQAWALTETAAGGTLQYYEDTICNGVVGPPLSLLGELLVRGPSIFKGYYKNPEATNEVIIDGWFHTGDIGEALPNGHLKIIDRKKNIFKLSQGEYVAPDVLEGLYSNSQYVMQVMVYGNSQEDYLIGIAVPEKEIILDYFKNEKQENENSEEFFQRICQEEKIKELILKDMEKIGRETNRFGFEIIRNIIIETEPFSIENEFITTTMKLRRKIIENHYKKQLLDLYLNKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQT1</accession>
    <name>A0A9Q0LQT1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein vps13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQT1"/>
    <dbReference type="OMA" id="QTRRITI"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="3">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="4">
        <location>
            <begin position="872"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1029" mass="119055" checksum="0A1A26B6B0849F15" modified="2023-09-13" version="1">MCVVMMTREQKERRSEIISLDLSKIQNEKFIEIHFTDKKSNLFIQMNQEPETQTRRITIFSKYWLINRTELPLFFESKNKTDPFEVQISENKIISLFHSDKMIMRIGSSSSKLATQLIPIDSLGIDKEIQIEDPEEKVTYFFGLSIQPSPLTKLVSISPRFVFMNNLPRKLFFVESGIQAKETPFSVESGITKSKIKWGNQVTNFRTSFENQEQKQTNQKRVVLLLDHFSNRANTWLWSCEISNRNLGNFFFKLSSENTTRFEIIELLVKKQQSTILISFSPTDPKSPPYYIVNNTNFTFKMRQKNSKIEEIIPPSFSTRYAWQDINLPPKVELRIIGKEFFQSVNMNKIKTYKRVKLFADKKDVECSVFVVGKSQVLQISEIGSFHSESSLNLHLKHAQRDVSLQADLNLSSLFISFLSNEPKEVMLLSLKDTKLFFEKSNIDSNVTFSIQNLQIDNQLSSATFPVILAPKPVRNAPPVFQLSYVLSYLNAKDMMYFKYASILLQVLELKLDDDLIFEILDLISGMSSTEDQSKSTYVESNENNENDENNENNENIQNDENDEIIQINENNQNDDIILQSKENSFLEQFFSLDYLQTISSSQKVYFELLHLNPIQINISFHISPFLEEKNIELQNLIKSNFGFISLFDFNDAKIRLSGIILRDLYKSMDEIIVRLLDHYMSSAIGQVYKIIGSIDCIGDPVGLFGDLGKGVYMFFHEPIKGIVKSPKEFVKGLGKGTWGLVKNSISAPLNSSSKFVTSIGNGFERLSLDPEFWHKRRYNLQKRPDHIFEGIYMGSKSLLYSILSGLTGVIKQPIVYSKKKGISGFFEGTARGLVGVVSKPIIGATDFTTNVLDGIKNTPKIFDLKNQKRQRIPRHIPISRKLLQYNESDAKHQELLNSIQNGKFRKETFILYHVIYEPNLVLFVTDRRLLVLYKKKIKHNISFKRLVRLDFNFASNCLIFKYIKNSKEKINEISKILIQLKFPIHQQTLDLIRDIISQSNTSFHHNKNLNYHYKEKTNEETNQKTNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQU6</accession>
    <name>A0A9Q0LQU6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-dependent kinase inhibitor 2c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQU6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="293"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="388" mass="45423" checksum="5BCD4D10381227BA" modified="2023-09-13" version="1">MVQQPKEDFMQNKNQNQNYMDQNIPYSSIKPQRKAIHIEEEKQSHFSPNFQAKNQNQNQNQNQNQNQNDSKSSNLLFNTYFHHDEKEIERLLKEGALSHDFENTPLHAAIQSHCSHNIIRLLLNHGAKVNMRNDLPPLYYACKSGYPVTKLLLDFGANPNLLFEEQFCQDQKTEDLIIRYNSLVEDMQNLLNNQFTSDLSIRTKDGRILVHKNIVSIRIGSITVLQDIFSKYSTNVANDIAEWIYGKNETEVQFLSNIHFFMEQLGIKNWEKLSGRNGLLQDLSRLFRDEKSMDCEIVINNQSFKVHRSVLMARSNFFLEVFKGNLSIHREKKSFLTQTIQELIHFFYFDEISSGLPKSVLNELKEAVSYYELNPNTYLIHLLNFYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQX6</accession>
    <name>A0A9Q0LQX6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group xv phospholipase a2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQX6"/>
    <dbReference type="OMA" id="QMTPPGV"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040459650" evidence="1">
        <location>
            <begin position="27"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="437" mass="50241" checksum="2474BB8153121B1F" modified="2023-09-13" version="1">MVFLKSSSKILFIFVIFHLCSLSLLSNDFEKQYDYDKDTFIFKKVEQELEEIDPIESAKKLAEEIKMKNDRLNLNPIIFIPGLGGSKIETKLDNFNTKHWFCEKNKDWFRVWLTVELYAPEVVEKSYNQKGVSVRPISGIEGVVNLDPTLFFISEVAYFSRMSKVLEDLGYQEDKNLFALPYDWRLAPNNLTDYFELLKYTVEYSYSINNGMRVNLMTHSMGCTIATYFLANQTQEWKDKYISTFIPLSPPMGGVFKGINSLVEGENFGIPIIIGSEIKDLEVSLPSIYYFLPHSPFWTQPVVKTASKDYYPTFDDYNVLFNDLGLPQYSHQLLQLTWKDSLVFNPPGVPTYLQIGSGIKTPIYFQFETDLNGKHEIIYGNGDGTCNHDVMIIPCTEWAQGQTQPVQCYIWNGAGHQDTISKDEIIEQILQIISNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRE1</accession>
    <name>A0A9Q0LRE1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRE1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="155" mass="18857" checksum="3ADB79CCC1FC8F2C" modified="2023-09-13" version="1">MIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITKRMINETEKGIDYFQLNQTNPNLFDLLIKKFNNQKKENCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRK9</accession>
    <name>A0A9Q0LRK9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-7-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_05918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRK9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="387" mass="45085" checksum="10291A27A8D5E081" modified="2023-09-13" version="1">MQKTNENEIFQNEPKKVIVMDNGTTKTKIGFAGDDSPTAEFSTILGRPVRTDYPYTTRLDLYRCGDAFESCRGLLTKVLPVQKGIITDWEHMEIFWEASFKYDLRIQIEEHPLILTEKPWNRKKNKEITLEYFFEFFHVPKFLLVDSGRLSLLSFGQRSGTVIEIGEQNFHVSIYNNTSYSPFAFVESEISGREATEHFLKLLSNRSFFLTSFAERQIAADMKNFCSVSLDFAKDFSNEKKAKIIYEFPDGQEIDLYEEVFLVPEIFFQPSLIGLDSLSVQDAFFELEKKTEKENFFTNWGKSKKEIFKKVYLTGGSTMFPNFAERLQKEINNFGNEFETEVISTPERKYSPWIGGSILGSLKEYEDLFINKKEYEEFGDSIIYQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS98</accession>
    <name>A0A9Q0LS98_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein rab-35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS98"/>
    <dbReference type="OMA" id="YELDEVH"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="208" mass="23914" checksum="41634FB1E6BA65E1" modified="2023-09-13" version="1">MSFDFLCQIALVGASGVGKTSLINRYVDDVFNLNYRTTIGVDFKTKDIEINGKSIRLQIWDTAGQERYRISISSFSIYKKVEAFIIVFDLTKENTLKEVNNYLVEINQNCPPDVLIVLAGNKCDLENQFENLEEKIKEISNEKEFKLFKTSAKDGTNVNELFYYIAKTLKEKNQNGKFNTNQQKPKPKNKQEIKLENKGNKQGKKNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSI2</accession>
    <name>A0A9Q0LSI2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_05833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001072">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="9">
        <location>
            <begin position="2634"/>
            <end position="2734"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="8">
        <location>
            <begin position="2743"/>
            <end position="3034"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="3174"/>
            <end position="3206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="3221"/>
            <end position="3262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1410"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2289"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2566"/>
            <end position="2596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1416"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1453"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2312"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2576"/>
            <end position="2589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5077734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3399" mass="398509" checksum="3B1A28777FAF5912" modified="2023-09-13" version="1">MTSYQHTYKFIAVGAMGAGKSSLIHQFTEGKFYPDCPHTIGVEFATRIVEVMGEKIKIQLWDTAGQERFRTITRNYFRGALGVLLVYDVTRRNTFNHLNSWLTDARNLTSPNVTIILIANKVDLKERAVTREEGERFATENGLEYIETSAKTGANVEECFLKTTRQIYQKIKEGVIDSKSTNGTKKSSQVAVESKKLKIFQKSSQEEPNFLNHIPNGSNLQKIWDLNKVINNKQDKLSWFFQFAELFLKSYSNWKPEIPLSKKLDVISAKLYEEDQLHHEKLIIETLQILYDFLESLSQKIEILEISCSSLISIEMILILSRSIYNQKNLLKYQLFLFLENIAHQVIFRASSLLEQKRFEEDQRDEHSCNFFLVEYLISKLIAISNIYINSPFDQKTMKSILPIIIQFSSKFLLRLVQFRKKFIFNQEQHDLLFDLIDLFRILGKRKLISPEYLLFLFKTITPILETPDFTLPLPENFFKRETTKNAQNTLDYYLSLYFPPSKFSQTEQERKSYEFQIRIVVIDLVYIVIKDNAQIETLVCNTIPLTIFTNLIFWVFKSFHDPKSININNNNNINNINMNKKNIIINSNDQIQSEINTEQKDSNKNISETKLELPQEIPVREKIYSDKFIPLPKIPSSYLNNLKTHQLFANLKEICLESKKNKTLHKSQNQLKNTKKKTKINRKKLQFQDLLLKDYQKNKIEHELIHSLRLYTLDFFAALFTDDFSQSFYKNQIWKTMILEIYEDSSPQNEIVKSQLFQLFTHVLTNYPNHRNQISILLEIVKGNTKRLDILYDITKYFVKILKSKIRLFSQLFFDSSVFEFYSVLVDRLSKITEQQINTVFDETENTKELYFQVRYQVFRLFDILFSDPIACSRALEINSWNINIISHIFEKKTKTFVLNMMYRMMCSINPPFLGTYEKFFYMYLELVLSLSQLYKLREENDQDVSDEQIQRYIKSSRKNTVNIPKELPEPPVVYIQDLLKLASESIKSNREALQKLMPDIGIFEMLISLLTIPGLNTKVSHFVVQTLTELLYCSYENVSRFDRIIGFQVLGSLILRSQMNNPDERIFYLLLNLLVNTGKFDKQENFEIKNHYLISMLFNLYFKSENLMLFSKLLDLFLDICKKSIHNTLCCYNAELISFLSETLPKIEDSTLQKKVSRLIMAIARLGISIKDMHILISNINKFKREDQISYLFFLFKMLQEMAKEYKKPQPFSFFDFHLGHLSLPTIEEWPQNGWSFCTWIYFQSLENYSQNHHFDQDGQTIFSFLNDEGYGIEFSVLLKINLEELSKEKAPKPPQIVFILNLNTQTENTSLSFDFDLPKSKWAFVAISQSPLKTYNSSTKIQVYFNHHFKEQYCPKYLSNILLTKNRIASKFSFESKLRNSPNFVSRSPSLVFQEIEQEIDKEIVSENDQEENLTSKSNNSNNSVLTTKSENKTNSNSQNQQSVGNVQEIKLDGTQDPKNIQEDKDIITQEEKLNEEDHIMLQEKDKEKDSFFLGQMGTIYFFQEFLDSNFLMEFSHLILKDSIPFDLLDPTEPLDNPNFEFFCSLSSKLFLVYHPRAITKKKYCLDLSQNSTTENLALISGMVTISTKNLEGIIESLGGIPVFFPLISHFDILFSGLKNTLCSKEYEEIKYLDQTFKIFADIIYEVESFQTEFLQRYSFSLISDMISNVDPLFISTGIIQIAQNILQKSRKIAFINDIFFNFLLGFDLWVYCSFEVQKELFRLIAAVLNNSIPNDTLKSITFPTSKIVEILILYYWIIPESSSRATETKYNNKTNREIKRTLTVEETRKLRDIILSLLEERIEILARNIPRNYVEIKTTLTSTIYQFCNLENKKIYVDLLKMFVNLLSKEKISLFQSPEPILDSSLIDPLVYLLSTPEPSLRKLVLESLYQLDQILSQKRSLPSKFDINHGYAIVDQLLLENELTSEIANFLFEIMLTPQDPKAQEKLSLEKPYIFFTILNFIKKYKNIHAINFVKRLKYELSKEKGSALSLTNLTAWQLKLLDLVSVEDLLVQEQTFYQSPSNETIVHIPTLINNAVFDFFEFIHTENILNESKGFQVLFQTIAYIGLSIADQSQNEQIILRRILFDLCHGLASQSMIFLTPNFTHSILRNITTVIVLIQRYFYFDFSYILIQVTKHKKTSLAENDSQKKESKAEIIKLESRIKHTHDHDFVVVSGLVDFLEKSNFWIMLSILSKNRPKNSNLIRSVLLLYLHFLPTLDPQKCREFINKIKLLILFFPDNKIVLDVVAILFNCLNFHIYDPLEGFNFLIPERKILSDLSDVSQDNDSKIKRSTPDISDQSGIDLDSDSSVNQNKPDTQFQSSETSLEFEKISESFSENPNIQNLETMPNETKQIIFEYLLSVIEENYFFLGSFFLDENNRPILLDLIPETLIRNANKQKIKEENFKNRQWHYIWTEYLQPTLIKIDRETRTNFQGITHKIYVLYQENLFKLYENRSFLLNQKKMNRVNIIQKTKDFIENDKKKIQKNQILYNRKIRFIAKKWKRLSRQLMFNKFIWEKYLPEALTFEPHFKLDKVEDKIRVRRKMRLNYIFTNHLNRQSFFGIKPPKEQNNNENNNNNNENNNENENKDSRDVENLLQFEDLKEKEEQEKKKKLKEEQQKQLNEIIEYMNQDPNVLAVKCELINGIFHYEGILEITQSALNFYIDFPSLEDDCPIQISDKYWKIDDIIDISKRRLNFQPTSLEILFRNRKSYFFHFSEENFLSVTQKLLTFKHLGSFLVFDQHENLKAITKQWKNSKISNFEYLLKLNFIAGRSFNDLSQYPVFPWIFSDYESNEIRLEDPSFYRKLSKPIGALNKKRLKIFIQRYKNLADHPQLDPPFYYGSHYSSPAGVVYYLVRLEPYTSFSIHLHGGRFDHPDRLFGSIGLSWKSCLNNTGDLKELIPEFFYLPELLINDNNFDFGISHTNEQISNVTLPNWAKSPKHFIEICKKGLESEYVSQHLNRWIDLIFGFKQRGKEAEKAYNVFYFLTYDDSYDIKELNKPEEIKRIKSQIENFGQVPMQLFFKSHPRKKMATQQNTEQTFTAEMFNSMRIFSSQISETAVLHLKFTAQTSSMSWMGVFHKLYSLNLTKKLMRHRWIIDFTASITKSPFNIEVDPLPKQRKIGVSFADGVNLRTCYLLSKDCSFLFSCGYWDNSFKITSINPLRLVASVNFHKDIVTCFAFDSSNILATGSRDYTVAVWKIFPEKKPFAITRNYSLSGHQAEITSLAINSYLDMIVTGSKDGTCRIYSLYSGKYSTTLDIKQIYENQKNQPEIVNQTQVSMISIFEDGRILVFSVNRPMISIFTLNSELILSSLLDESITCWSFLANENFIVTGSKKGLIKFLKVSDLSLVHKYDVSYPVSCLLFSPESTYFFAGCENGKLLVGVFTYYNIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSL5</accession>
    <name>A0A9Q0LSL5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 35 member f5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSL5"/>
    <dbReference type="OMA" id="FWCKALI"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="171"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="455" mass="51923" checksum="83C8B0776561FAE4" modified="2023-09-13" version="1">MAFSRKNCFGIFCIFIVVFIWVGSSELMNYLFTSQGYDKPYFLAYFDTGLFSVYLFGFLFHPKWKRQCSKNCPKETMKEISSCICCRNIKKKEILIKKDETESEIESISTNESENEKFIENENENENENENENENENQNQNQNENQKLIESNESSDDLQKLISLERKELEKPEKIKVPIAEIVKISTTIAPFWFFANYTFNLSLSLTDVSSNTIISATSSFFTLIFGVIIKVDQFSFAKIFSVLLCFGGVICVSLSDRKNSSGNSSFIGDLISLLSAAIYGIYTIMIKKKLDDKNISGPIFFGFLGLSSFVLLWPFLLLLDLTKLEKFEFPTSMNLVYVVLNALVGSVISDYFWLLAVLFTSPLAATLGLSLTLPVAMVADIFIKSRKFSLIYIFGSLMVIFAFVLINLNEKFSFIDHKIVSCCQKKKQKLNQNENQNENQNQNENQNENSTLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSN5</accession>
    <name>A0A9Q0LSN5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSN5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="228" mass="27921" checksum="489CA83A275DC112" modified="2023-09-13" version="1">MKKINEVEEQKFYVIFYYLYFKKIQIHQKYLIVLNNFGNIIIWINFLQKLFWIYIKESNMNESLEIQDLPSRNLSSNKQIFDFWKRLISKMSLSMIQKTKVTYENTKLPFFDNIYTIIKEDQFELEENKSLLEYIEETISNKKDIYNSEIIILYIQDLQSITLKKKEKEMIKALKIDIFDFLKKVSQENRTYQSILVEIYKVDFPSFHSKLKLILEIWTEMKPIRKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSX8</accession>
    <name>A0A9Q0LSX8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_04762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSX8"/>
    <dbReference type="OMA" id="AYRIMAN"/>
    <dbReference type="OrthoDB" id="409897at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022083">
        <property type="entry name" value="KBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321">
        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12309">
        <property type="entry name" value="KBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5078437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="614" mass="73564" checksum="66A394287374EA50" modified="2023-09-13" version="1">MENNIEIEKKDLEPQLKLREVKNIRKEIFSLEENSPEKIYHEKIEKLYNKILDCLQEPQIKITGKFLLKITNELEFLKDVMEKFYPRNYRLQEVYNQRGVLYAECGDIPNAIKTLEKSQEIYLENKKNSSENQEPKYLQHVENVYNLSLFYFAQVYQKIGQKEIASFYLAKTLERQIENWKFFNVDPLKWAENATNLYQFYLFNHQWKSAEAVLLATKYVLEISNEKGIESDSNLDQKKENISLQFFDMKENSVWGLLLFNFGSLYEQLLLMTAMRKNNKVYEIEENEDEKNNENEDEKNNEIEDEKNNEIEDEKIKEIEDEKNNEIEDEKIKEIEDEKIIENPLQIPRNPIKFIPFQSFKLKNQDPLLSTQITNYEQIKKLFKKGKEYLEESEKILTSKKGFLNQWIEIKRLESALFSTLIPWEEDKKRIYSMNRRRLTILFQTLPHLQNLKQNELKREIILEIGKIFELIIEYKAETTNHKVSQQNEILEQCCYFYSCFLALFNKENAENPNFIIKENSQWDPTIIKEPSFNSFEEASDYITIRLLLSKIISQIREQNQQKAKIQITAAVENYQWVLDYLDKHPKLATKFQTEKEIATEMIPYLKTKFRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LT72</accession>
    <name>A0A9Q0LT72_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LT72"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="264"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="486"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="591" mass="68688" checksum="F61120EB97FF8364" modified="2023-09-13" version="1">MNEILFFGSNQYPILIKNEPNKITKPIQFNFENENENENEKQIKQISTSNFSTIFLFENGKAIEYLNENDSKQNPEKIQIEENIQKVTAGFQNEAILTIEGNVFAKGKDINSNNPNEFINISSLIEDKNDRIIQDIVSGWDATYLLTSNQNAYGIGSNQLGQLGFDSETLKKTEKPILMMKNISKIFSGNSSTCVFLLNSNQELFVCGDNEYNQIGLSKSKKGYIDKLTKIQNIPKGKIIDIQCGYFHSIMLIENENENENPKRKLYSCGYSGNNGLGKNQNARKFTEIKSSLFEENDDNILDFSVGNAHTLILTSNSKLIVFGYNYSGQLGTEDTKYQLIPIQIELPKLRFNENISNYHISCGFNNSFIYYSPSFSFSNIEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNERIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTW6</accession>
    <name>A0A9Q0LTW6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HQACGLI"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="1511"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="940"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1562"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="970"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1566"/>
            <end position="1586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1615" mass="187269" checksum="29E878D8C7574A51" modified="2023-09-13" version="1">MSNPLLDTSSDNEDPIETANIPTNTTLSMLLDSDLDSNSDSETNLKPKKKDKKKTEKKKDKKENEETKLNVLLDSETESIKSDQDEGVVEDMIKQIGEDAMKSIIDGDDDVDDDIENIQNIQNIQNQSNQSNQKNQKDLEKEQRLPQIFKSQAPKIQRLGMLKQVELAEKLQKLGIGEPTCLVTQKNVMAIGSEQGIIAIFNHSQKFLYSIKPATTILGSVTCLDFSSLPDCQEWLIAGYHSGSVILWNWKTKKEMKKVNAFKNPVVDVKFLSEKGKTFCIDEIGNINILTFSKLLMWKVSKQPHIIEGIVNSHILAAKPLLKNDLNSNIDAPPFIAIISTKKVFIIQLNPTIAILFYFNQPPDPKKKTTTFPYFAWKPPQEFETSTGREISFPMFAVVWGKTLSIFQIEIQQITDQNIQESVVQFIPRTSIDLSFNGRSVFWVGENSISIFDARGIGYLYDPFSSTEIVDSLMFSSNSFKPQKIKTEKDTEKTANSYHKSIVRHSFSEILFFGKNEFNVFIILSFHDTINFLLQKNYFIDAINLILEFFSGNAKSPSSLPTLHYLERQAIIITRLLNTLGMFIDISLEKLKLANQKNENNEKNENNENNENNENNENNENQENQENQINHENQENEINDSNKKLIAQELSMLAISCCQHTEQYTFLFHTIFSKFEKSNFLSEILERFEPFLITQTQINEKNIATNGLTGRKSQKNISVRNTYRSGLGTSDDFAKIPGKLLLSFVKNYYQNHKLKRAEACCLELNSSHLDPKFVVGIYRHYHLYQAMIRVSNRDLLDFISPLYYMLNIFCYYTGQTNQNQNQDQNQKNSQFQKSRFFVHQHAKVENPEEMMKNLSLLIPKYLNYILSPNLRTISEEKLLEIQTDLYSLLFKKHEKDARGSYPYLLVLLLMNVHQVLESVALICERIEEYQMENQMKITEKSKTKTKTKTKETETIKESPQENNENNENINENDENDENINENENENEENNDKQKNENNDKQKNQESTKLSITITENAFAIIESILLDSEIDILDPLKISESSKFKPKDLEEFYIFTSYYLMDHKVRISQRLLGAIISYLVKLEPEQNMEEKLNPDEKERLFLKILKGPNAESFDEKKLLLLSETVGYDKICEYLYIRTNDYINGFRYYLRDEIRKNDVFILIDGVIDNPESSKETYEALKNAILEHLQSLLMIEPLKTAKLIMNSFPEQHEIIMKKLPSTPKFHYYYLNGIIQVIQSKNTKKNKNRSEENEENQKKKIELTSELNECYIRLMCEIEPGNVLAYLRSSENYRLDYCLQATTDFNVADARVYLLERMGDIQSAWKILLEALSENVNKLQSKILESQEQIETDVTVEESTVPEIIQVRKILNESTQFCIRNVEMTTTTAQEMWFHLLDIFTIPIQHLMKQNKNKLETLVSQKQYDVLTGFVLFTLNKMIGHLSMSDVLDKLIKDYREQKFDKFKSVIQSMIDTYAYETTILTTAKRLLVQDSFRTMRKLFQQRSSAVLIHEMKCGSCGNKIQFGESEIAKTKNFVLFNCGHIYHNECLVTGKKCEICGRAGQSKRKMGKRSETKDKEKDEKQNQKESIKKKQTPTVNTYLPLIRRARRSLRNNSIFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTY0</accession>
    <name>A0A9Q0LTY0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_04600</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTY0"/>
    <dbReference type="OMA" id="CFVLWFG"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000036">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="754"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="803"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="832"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5078877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="944" mass="104772" checksum="CB20D80851D2536B" modified="2023-09-13" version="1">MALNFEINQDELFGLLEIGEPTLKKRLEDQEGIEGVMKKVCVDPKVGLRLSETQSGFKTRREKYGKNQFPEQPTKSFFTLVFEALQDSTLIILMISAVVSLVLGVTVEDPRTGWIEGTAILAAVVIVCLVTAINDYQKELQFRALNKVKDDVLVPVFRETEPGLSAAVNVSIHEINVGDIVLLSAGAKIPADGLVIFANELEVNESELTGEPKAIHKNKNENYILYGGTKVMTGEGRMVITGVGIKSQWGHARKNFTKPPDPTPLQLKLTDTANLIGIIGTVSAGLTLLVLVIQWVLKNMAMENGFSFESFVEVVDFLIIAITIIVVAVPEGLPLAVTISLAYSMKKMMKDMNLVRRLESCETMGNVTSICSDKTGTLTENQMTVVAGYFLDNYYKEIPEKFDDKIMEIFGEGVATNSKAFWDGKQAVGSQTECALVNLLMKLKYPYIKFQKENEDKIVKTFTFSSARKRMSTIVKKNGNYRMHMKGASEIVFGKCSHFMDKEGGAQKLNESKENEIKGLIQKMASSGLRTLTLAYKDFTKTGKETFDEPDQFEKDLICIAIVGIKDPVRKEVPRAVKECQNAGITVRMVTGDNIETASHIARECGILTDGKAIEGYQWRNLSDEERKKLVPELQVIARSSPNDKLILVKALKEMGEIVSVTGDGTNDAPALKEANVGLSMGITGTDVAKEASAIVILDDNFKSIVNAVLWGRCVYDNIRKFLQFQLTVNFVALVLAFVSAITKKGSPLKAVQMLWVNLIMDTLAALALGTEPPTRDLLNRKPYAKTDSLLSNKMIRNILTQGAYQLSVLFFILYFGGSFFHYDISIPEQQVHLYTILFNSFVLCQVFNELNSRKIHDELNIFQGLFKNAIFIGILIFIVAVQFLVVTFGGKFFSTTPLSLDEWIISISIGAASIPLRYVFRLIKVPIEASQLPKKSKAQKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTZ2</accession>
    <name>A0A9Q0LTZ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000021">
        <property type="protein sequence ID" value="KAJ5079926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTZ2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="300" mass="35765" checksum="CCD285290AA6BECD" modified="2023-09-13" version="1">MRNKCSCCFGHNGGFCILIFLCAITGFILLVVGSSLSIKLLTIFGGVLFGIPFIAIPVIACCDAARNCCSCNCNCDSCCFSRNRRNENENQNEYQNENQNQNQNQNQNQNQYRNQYRNQYRNSYQNLYRNTLDTPLFIQEKQKTSETTIVKEEEPKLKGDEDFETMIQIYKKEKNEQDQTENQQKNEFEFGNIEIPNELNETEIDEYKKGFNPLFNQQEPQENQEFNQQQNQQENQEFNQEFNQEFNQEFNQEFNQEFNQQQNQQENQEFNQEFNQEFNQEGPLYNPYYQDFSNQENKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU19</accession>
    <name>A0A9Q0LU19_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000019">
        <property type="protein sequence ID" value="KAJ5079971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU19"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="48"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="278" mass="33765" checksum="6FF2EC993FDDDF5E" modified="2023-09-13" version="1">MDNNNNNQIQNANQNENENENEKKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLFISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIEKRVNSLKLRKYKNKMNEKKRLFHSFFSLFDKDSISKQDFDKLKQFDFFLPKFFFNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUD5</accession>
    <name>A0A9Q0LUD5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sin3b-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUD5"/>
    <dbReference type="OrthoDB" id="4728498at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="644"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="834" mass="97628" checksum="19D3BF991A2F2E11" modified="2023-09-13" version="1">MQQNNEFNVSNKSENKRDQYIPQTTHSQTLQHTNMQTRTTTSNNQERTAEKDNAQTNTSDGNEMKNPEAVEFLGKIRDYFSNNEQKMQTFLEILREFKYRRQDTPSVIAKIIQIFEGDTDLLMKFNRFLPSDYKITEAHINRKDNREFLKFIHFIEKTLGSTSTKWSKFVRKLKKLQKGTLSFQEFQQKMNKLFSDNPAITKGFTQSFFEKVHYVQLPFLKPLVNKRMKKNTEKAWEETIYTSAKRAKKSRKRAPKPQGLEGTEPFDPQEFSTNIKAHCQYLNIINTHSALLKTSNTLQSLSSFSSFSHHPDPSEQLDTLSGLVRQRKKIFSKNFKLMKKFQFSIEKMNEILELILASKQKNHDQNALNIISAKISSLFQYPDFCLLLQHVYGEKYESMFDFLENNPLFAVPSILRNLIECYDDISTNQLQIIAETDKLLSTHSSKIQDLQFLNYSKQFSDFLSPSFLALDTLEKETLDLPITLEYSDTKLIPTISQLLVIRLQQGILGEDSQPKNQKIEIPKHIHDNFENQLDFLDFQQDLQQEIQQEIENKEQNTKSNQIMQMDLETDNALNETLKQLTHFFFESIGASKKFIAYSSDEKRSKETKEKEKEKEKEDGNLKPENSPNIFERPFDFLSTFFEEDSTTNPTKTFQSNENENSNENEIQSETQNEIQNETQNERRQKNVPNSKSFVGDIHFCCFIRLHYILYEIMMKLKNSNVSFSEVFETISHFLTGEMTFENFYSWLSSFPSVSQIKASQIRLVMNQILHQVVAISKDPLAKLLFQKSQLDQQKIQQEVDSPLFLFTTQKQTLFEQLDYEPISITIRTLSNQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUE3</accession>
    <name>A0A9Q0LUE3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adp-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_14593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000037">
        <property type="protein sequence ID" value="KAJ5079117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUE3"/>
    <dbReference type="OMA" id="QESCAIT"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5079117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="186" mass="21806" checksum="3CFDBE806591190D" modified="2023-09-13" version="1">MGNILKKQITKYLKEEIKLMIVGLDAGGKTTMLYKTKLDVQTTIPTIGIYLETIEYKNLMIYSWDLNTGLRLGPLYRHYYQMMNGIIIVVDSNDIERMDELKEELHTILKEDLLKGLPLLIFSNKRDLPNSLNENELIDKLDLDLIRYRKWKIQESCAITGEGFYEGMEWMFKNLEIKCNLDESDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVU8</accession>
    <name>A0A9Q0LVU8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000016">
        <property type="protein sequence ID" value="KAJ5080013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVU8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="85" mass="10065" checksum="3F4ACB86C1BE95FE" modified="2023-09-13" version="1">MLKLNDSTIYPLSSPSHSKFSTEMKDIKIRLRLNEIRKDYNDQDEQFLHQSEHLDNSKINFDVKLMKEEDSPHIIDSLSQVFDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW47</accession>
    <name>A0A9Q0LW47_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sorting nexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW47"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="458"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="827" mass="96687" checksum="BE4D12D29E9EB9FA" modified="2023-09-13" version="1">MSIEFSDKDFDFLLGNNSNKTNETQEKETKQVPKKKQKQKQKQKQKQKQQKQKEKEKEQELEKQKEKELELQKQKELELELQKQKELELQKQKQKQKKKPKPIPKPIPKQKVINKKIPSETSSETSSETDTETETETDTDTYTSETNSGTYTYTSEIDSSEIEILDTEKYTKTKKKVESKKKVESKKKVESKNKKTESKNKDEAILENQEKQHQHSKSKSKQIDKDKNETQEKPHRKHTSHHKNEKEKESTQKKSKEAPKEELKEESKEELKEELKEAPKEEKKSSFKTKFAKFKKKSFGLFKNLGKKKKDQKNNINETKKETEKEVIEKKDTKKREKNHVEKPIEKNEPQKKLTLEQETSLKKVMEQSKTISVPRRARGIKGRRRPSKKKLENIQTIQITQDAKKEINTSNDQTKQHQKSRIPKENYRNQTGNKEEKKAENLLVSQSIIPPEKIPSPFTQIHVSLPQLVGTGRKKSVSFEVSFSANLSESQIMINRKFEDFLWLRKSLTEEVPNFIIPVPVEKSMIKKMDPESSEILRRALERFLLRISYHPVLGNSASFHLFFETDDSSVLQKTGFKKGNPTQGKFTANINEIIQTQTLFDEDYLNIKTQELNILEKNAQILSRTISQQVALDSENSQAYSEIQDAVKNVICKIVPNQQLDHYWDSFITTSNHISQFFLAQHKLEKTNLEQPIEEIFQQISGCKSAINHFQKSQSSLQKTKKDFESKKQKLEKISQQGIPSKEEKAKQDLFSSQKKLESEEEEFKKSIKILSSEFQRFKTQTTSNYKNILLSFAISQMRFQQSVFKQWESFVSSVQESPNPETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWL1</accession>
    <name>A0A9Q0LWL1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-d-alanine carboxypeptidase-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000045">
        <property type="protein sequence ID" value="KAJ5078758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWL1"/>
    <dbReference type="OMA" id="AGWAVRY"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF11">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040469443" evidence="2">
        <location>
            <begin position="19"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="24"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="428" mass="48350" checksum="B3FF378536B4AA9F" modified="2023-09-13" version="1">MKIGLILFVFLIIGFIYGYDWTPVDQVLENAVKEKAFPGCTALVGSSEGVIYAKPFGYYTYGLPAPVTHTNPAVQMDTMYDLASLTKVVATTTAVMQFYQRGELDLNTKLIDPKLLGEKYNNNGKDQITVRNLLLHNAGFPPDPVPDYWNKTFGCPEAQKYYPPEDFNCRAKIYSSVMTQTLIYPTGSKYIYSDLSMITMMYVVGKLAHDLKYITPEDLDPICVANSSINVNDLNGLEQCYYEAYVRIFVLSPLNTQRTMFRPNVSLWGDCSPTENDTWFRHQVIEGFVHDGNAYIMGGISGHAGLFSISQDLGYLMEKLVFAPEDSNYVNKTTVELFTTIYNETQSSRALGWDTNLENYYCGDLSQKTFCHTGFTGTSICADPTRKLYAILLTARVYPTRENNLIRKVRTQFGTAVQQVFDQDEKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWU2</accession>
    <name>A0A9Q0LWU2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000045">
        <property type="protein sequence ID" value="KAJ5078755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWU2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="208" mass="23729" checksum="A09B93301619D328" modified="2023-09-13" version="1">MQTKGRTSAIYSQNQIKNQKTDDKENTNSAQQAKIQERVKKFQNIKLIQIRQAQKLEKQNITAGTVWRPKGPVTIQAKRQQNKLADELIKKMSQPKTEQKISIPTQLTKKSESKNFNENIKEKSKSKSNQNPNQNQNSNQNQNQNQNSNQNNIIKAKLDDPLQYQSPNAKQSNYVPVNILKKLGQTKSKDGRCFELLTPLAISGKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX74</accession>
    <name>A0A9Q0LX74_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX74"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="316"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="482"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="587" mass="68501" checksum="A410F8FEB98C5037" modified="2023-09-13" version="1">MNEILFFGRNEYPKFIKNEPNQITKPIQFKFENENENENEKQIKQISSSDFSTIFLFKNGKAIEYLNEQYLKNPNQNPSKIQIENIQKVTVGWENEAILTKEGNVFAKGRYINPKEFINISSLIEDTNDRVIQDIVSGIFSIYLLTSNQNVYGIGSNNFGQLGFDSEILKKTEKPILMMKNVSKIFSGNTSHRIFLLNSNQELFGCGLNRYGQIGLGESKKDKPKKLTKIQNIPKGKIIDIQSGNFHSIMLIENENENENPKRKLYSSGYYECNGLGKNENTYEFTEIKSSLFENDDNILDFSVGDEFTLILTSNSKLIGFGHNEYGQLGTGDTNNQLIPIQIELPKLRFNEDISNYHLSCGSYKSFIYYSPLSFSNLEEDLIKLFERKEFCDISFKIKNGEIIEAHKLILKYRLNQNENEKLQEIISKKSIKESNQIFEMIYSNKIINPILYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIEKKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNESFQIFEYWIYSNQIKDEIQITKEIIDEIKIGIDYFQLNETNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXB8</accession>
    <name>A0A9Q0LXB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immunity protein sdpi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXB8"/>
    <dbReference type="OMA" id="SWLNIPN"/>
    <dbReference type="OrthoDB" id="10639151at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="184" mass="21290" checksum="40F7783E91FD703A" modified="2023-09-13" version="1">MNSYSLSMLTILGLILVVWIHGGIYSKYLPDECASHYSFDGKPTGYSGKWTLIAVYWVAGTLIGLLFFSLPFCIRVCPESSINMPNKEYWLSPSRKSRTFRVLSSYLFSMGIVIQLFLIILFAVIFAANVRDPHEKPPYAWIFIVDFIVFILFFIFVIVKLLLRFKKPKNAIWLNHNDDPSDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXF7</accession>
    <name>A0A9Q0LXF7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Wd repeat and hmg-box DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_13933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000006">
        <property type="protein sequence ID" value="KAJ5080617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXF7"/>
    <dbReference type="OMA" id="RYAHTNG"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="18"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="433"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="725"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="826"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5080617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="876" mass="100293" checksum="D9D959BD6FEE44EA" modified="2023-09-13" version="1">MLNQNFNLNSQIEWNNVHEKNASDILLNISQKHILTCNLDGSLKSFHLKNLKNSTNQIKLQSGIQCFALSKNSQIIACGTKNSEVHLYNSKDLSYHSTLARKNLPINSIDFDSNSQNIIMSFNETKIRIINIENPKEFKEISSFESIVSKVAYDPKGKYFSTTEFNGTTQIFTENDLKSIQKFENNSKHQFSSNGKFGAIWSPTGDFICVPDLENNCVNIVSRDSWEKIKTIKKPSKHTFLILGISIDSKYIATLSEDQKEITIWKIRSGKEINHFAHNTKIVGFGWGTPKSKTCYILDCNGKLGTWKNVLEKKKENKKKKKKKEKEIEKKKEKEIEKNIEEEVVEDSDNEYADLDAINVSEDETVNVLSDGDDIDDIDDIEMDSDNNGGGEYDFEEVTNDNMHEIFKRIHQITNTKKWKEWQNSQDISQIMKPFQTSSTPFESNTRRYLAWNMTGSIISIDEEELSILDVEFNDQTRHRSFRLNNRNNVGLATLSHYGVLFAGSSSQNDQEDSRMDLIQYKPLNQWPTNEEWRLSLDSPESAVSIACAKKFIAVATNLNFLRLFSSTGREFFVLSIPGPILSIVSNGENLLSVVYGNETHNLKFQLLDMETRSKIHESLISISPKSKLAWIGFSSSNLFSTFDSLGILRVLSNNWFGYQFIPVLDSRKFIDQKDGGKYWPIGLSSNEFYGILLSAKDTFPSAMKKPIITSLKLSVPISGQMEDSDLLQELILEKVMESKEQFNSDPQKQKTRWIETDSLLVRQYDIYCKTRNNIKAWEVCKEFHFQKSLGIALLIASKTGLNELAEKIEKLILKKKNEEKQILNQNSNQNSNQNLNQNSNQILNENPNQNQNQNSNENLNENENLNQNSNLFSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXX0</accession>
    <name>A0A9Q0LXX0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000006">
        <property type="protein sequence ID" value="KAJ5080629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXX0"/>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="17052" checksum="B41A8CD5718B13D1" modified="2023-09-13" version="1">MDMILKLFCVQWSPLLNENDLENPYHSILASGDVLGQLIIWDPINAKIITKLPDIKKRKQRRKILEIKWIEQNKNYLLTLQTPSIITLWNINLNSTNSEIIEIWQLDLEKTNDIHESCLFFELNTSQNYSMIIGSDTGNLFFTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0M017</accession>
    <name>A0A9Q0M017_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0M017"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="89" mass="10473" checksum="80E4A01FA2C6908E" modified="2023-09-13" version="1">MFFLDRITYFKKKITIKKRSAKVPGPEVERTSDKNFNIHLIECEDFFLFEFQLFGLLFVIAISFMKALLRFFLFYKVGIKACDSTGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4L5</accession>
    <name>A0A9Q0R4L5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_13232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4L5"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="229" mass="26615" checksum="1B28C2CF7502B08B" modified="2023-09-13" version="1">MNYWDYLGKNFDSETPIEILEELLKESKEELKEIEEILEEDDPKLNEKATKEELEGFGVFEAPEFCVPIKCDVREFDWEKLAKEGPFDAIIADPPWRLAGPNPTRGVHIGYDTLTDNEIASIVQLLNNWGYRLETTIEWIKMGNSGRIAKGNGYYLQHSKETCLVGIKGNPKPKEYPIDVIVYPRRGQSQKPNTLYEMVEKMYPNGKYLEIFARRNNLRNFWISIGIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4P4</accession>
    <name>A0A9Q0R4P4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sterol-sensing domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_03479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dispatched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4P4"/>
    <dbReference type="OMA" id="INDPTHI"/>
    <dbReference type="OrthoDB" id="429851at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF3">
        <property type="entry name" value="PROTEIN DISPATCHED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="840"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="263"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="914"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="934"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5066146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="948" mass="109356" checksum="E3171EDA965CC8E2" modified="2023-09-13" version="1">MFASFRKKVAHFIANHPYVMVLGDKNFVVRSGSIASHVDATYMSYKTTFFDPEKNYIEHQPHQQNTQNEFGLTLLYECSGCDNLLTEKYLKKLYNYEKEIFGNSKYNQYCLKEVNNTECTAPWSVITYFFPNGTLVDDIEATALEILNNSVDSDFLCDKNFNSGNLKSKYLRSSYDFGLPLAGYENRKDRYDSQEEKFNDWIVGIVPDATKDHKTDSFQIFYLGDGVTDAYVNYLILRDGSLIFASIIMVFIYTWFHTKSLFLTAMGIFHILMSFPLSYFIYRILIGEKYFSMLNFLSLFIVLGIGCDDIFIMLDAWKQSLNQRGIGKDKQSRLEWSYSRASLAMLITTTTSAFAFFGNLFSPIPPIQFFGIFTGFAIVFNYLLVITWFPAIIIIWYKFGEGQCCCKTKKGKAKIQKEREERIARGEIELEEFQTKVSTQKSKDEKLRKLEESKKSNNPKNSKEIKKELESDYDYPIEDLEKNRKKKKKDKNEEKDSISESESYENDNNGKAIEEANLEEKHVEIKIDTESPEKKVLDKDTLDIEKFRFLERFFYKKYAPFINKAKVYLIIIFLILFGLGIYGTTKLEPATDPAQFLKDDDPLQRAASIQEEEFPTASISIAMQIVWGIDSIDREGRDRMEIDDLGEVIYDTTWDPTTPTAQLYVIDVCQQFKVLPDVKQNEFYCFMEDFRDFIEDLSPGVYSGFPVNSSVFHSALLNFTRTRGDESLEMDFFKIQSFYESSVRFDEYTSELRYFSIVANSTLMLSSPASDIRPVYDNMKDFMDKMNSEAPEGMNKAFITSDLWIYMETEEKLVSVALFNIYISLSIAFVVIVLSTGNVLTSFFAIFSIAGIVLTIIAFMVAIGWQLGIVESISLTIVVGVSVAWKGPVTPKTDLKYILSKIIGCCRRNKKKKDLKNRKKIKKPKKYYSESDDNFSTSSSEFFQNDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4U2</accession>
    <name>A0A9Q0R4U2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amsh-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_13490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000140">
        <property type="protein sequence ID" value="KAJ5066553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4U2"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="178"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="609"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5066553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="675" mass="79164" checksum="796AF5B0838ACEAD" modified="2023-09-13" version="1">MEQFIQNHIENLRKAASIDLLSKGLQLKYYFKIMDDLIPQITSYIDEKRYDYAYIFLYRFLLIGLREIPKNPDYRKFEYKDNVEEAFKKVERFKPGLGKIENKVKEEISKEYQEQQKQFENQLKDENQLKDEKDEKKEIQNPINEPVKNLQNETKSLPKNEFKPIPKELPNFNQIRKVHISEKLINDFKLYAINDLAKNIETCGILSGILKQNEFYITTLLIPDQTGNSYSCTALNEEDIFAVQSTNDLLCLGWIHTHPQYESFLSSVDCTTTLPYQLMLTEAIAIVISPKYTPKYGIFRLTDSIGMDFMRKNTKRGFFEFPSHVKGKIFESCKHVVVKPDEPQFKVFDLRPKSKQVDIEKLLKENPSLSQNNHNSPNLKGNVSGYSSLSGNSELKPFNSANYPKNQLNQPKQQFQQNQNYSQNPYFQQNQNYSQNPYFQQNQNYTQNPYFQPIQNYTQNPYFQPNQNYSQNPYFQPIQSNEPIQSNEDFQNNYQSNQLNQSNQLNQSNQSNQSNQLNQSNQSNEDFQNNYQSNQSNQSNQLNQSNQSNQSNQSNQSNQSNQSNQSNQSNQSNQSNQSNQSNQLNQSNQLNQSNQLNQLNQLNQNKNLKKNDDFLGENDNDEDEDDFDFDDDDDDDDDESEDENQNQNQNQNQNQNQNNIDDQILLKFYSLKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6P5</accession>
    <name>A0A9Q0R6P5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_02503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6P5"/>
    <dbReference type="OMA" id="GGRHPCT"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_uL2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5068561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="252" mass="27681" checksum="4C32F8709DBCE832" modified="2023-09-13" version="1">MGRVIRGQRKGRGSVFRAHTTHRKGKPKFRAFDSAEKCGYIQGVVKEIIHDPGRGAPLARVSFRSPTRYKMQKELFLATEGMYTGQFVYCGHKARLTTGNVLPVERMPEGTIICNVEEKTGDRGTFARSSGNFATIIAHNPDEGKTRIRLPSGSKKTISNQARATIGIIAGGGRVDKPILKAGRQYHKFKAKRKCWPRVRGVAMNPVDHPHGGGNHQHIGHPSTVSRFAPPGQKVGLIAARRSGKRTGSQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R743</accession>
    <name>A0A9Q0R743_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron carrier/ protein disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R743"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="348"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="777" mass="91397" checksum="8740332208B2D7D9" modified="2023-09-13" version="1">MSSVLKQQEEEIQKLQTKLGKIQKEIKDLEKKQETKRLQKKLETAQTLLKEKVAENNKSRNELNDLQQKLETIRKENMKQNNQYQNGLINYVNETNENKFDKVEKLKAKIKNLQNEKKKLENDNLKEKIEKELQENQENLKNLLKENDDLKQKLNETSQKNENFQSIYQKIVEKLVGVDNSKIQQFQQINKQIEDIKNQLQVYQKIEPKKQEKNSISAAKTLEELTKELENQKIENAKLEKEIEEMKLMAHNLDTANDGILTTDLEFSDLSELEDSGFSNLTTPIKTVPSENFQNISNTKTMENLQNLDQDKNEKQIEKESKREKLITKKKSQMIVKRTSENQNEIETIHELITIPQAVDYFKEFLSQELNQENIMFYMDAIEYRKIRSQKTRQRTAKAIYEKYIKPESLFEINIDFRTRNEIIQLVESDQISIEIFDKAQEVVLTLMEQNSFEPFKQSKLYQELIEKMSAGANYSIFSSIKTAVLVSKERNASILNLSSNAPDKTCDPIRLSQKLLEYLIDLLNAHYSISTEEINCELIRHSIPFRRFTQLTTRLQKVKLKGLVWSQLFIFFVNIYNVLSIHSALVNGISQERNFLKKFMQNSKYLIGREVYSLDDIKNGILRGNRDKGTKITSKYFKETDKRVKYTVSPVDPRFHFVLVNFDAQKLPVRVLYVETFYQELANATSNFLNNQVKILATRKKVLLPRVFHEFQRDFKRTQTRTLHWIAEFLKPEKAKQLLNDASSFTVKYHKPANAPLLVFDENYTSINQKTQEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7I5</accession>
    <name>A0A9Q0R7I5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7I5"/>
    <dbReference type="OMA" id="TFPMTEK"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5068774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="182" mass="21243" checksum="1CF46D5641FB2509" modified="2023-09-13" version="1">MEKKEIEVQEDFTKKNSVLDFKMKDIKGEEVDLSIYKGKVVMIVNVASKCGFTKQYEGLESIYEKYKDQGFVILGFPANNFLWQEPKGNSEILKFCSTKYHVTFPMFSKISVKKEPLYKFLTSKETDPNFSGKITWNFNKFIIGRNGKIVARFGSRKTPESDEIIKTIEKELKEELKEEKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8D7</accession>
    <name>A0A9Q0R8D7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8D7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="108" mass="12437" checksum="E2827A9083C4926A" modified="2023-09-13" version="1">MCNKFSKKCFENFCCYILLFTTIVAPFGFILLVYGHVKENITLMIIGGTIFGLPFLFSIQMCFWKKKTNDFSSASVNQTVNVDDHQTEIGTSEQVNIDEDRPAFELWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8I8</accession>
    <name>A0A9Q0R8I8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gtp-binding protein ypt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8I8"/>
    <dbReference type="OMA" id="AFARSCW"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000586">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="201" mass="23231" checksum="B8A5B9FF81179425" modified="2023-09-13" version="1">MNPIFKEYDYLYKIFLVGDSGVGKSCLILRYCDETYTDSYISTIGVDFKIRTTELNGKTFKLQIWDFAGTQRFSPYTRTYYKGSHGILLFYDITDQKSFDNLKIWIKEIQDKADDGVNIMLIGAKSDLVSKRVIDTETGEKLAEQLGYSFFEISSKENINVDEAFELLINQIYQRVSKTTQQNSNKKSNSNQKEKKGCLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8Z3</accession>
    <name>A0A9Q0R8Z3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adaptor protein complex 1 mu subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_10176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8Z3"/>
    <dbReference type="OMA" id="HSRLEIM"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="170"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5071544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="398" mass="46014" checksum="732058D8BC8D84EC" modified="2023-09-13" version="1">MACSGIYILDPHGQILIMRNYRGDLLIARIKKVIQKVIHGDEEKYKQPIIEDEDGITYAYIQHKGLYFVAATKLNSNMLMIIQFLYKLVQVFQDYFGDVDEESIRDNFIVIHQLLDEMMDFGFPQFSESKILQEYINSEVYKPEKQEPKTIPMAVTGKVSWRSDGIIHNKNELFVDVIEEIRMVVNSTGRVINSEIIGKVNIISKLSGMPTVHFGLSDNFFFLHKEAVEKEKAKKKIEVDDVKLHSCVKYSLVECVTEKHPGSRIEYLVKVRSFFREKFTARNVHVYIPVLKDADSPKIKTTKGKCIYAPKIDSMDWNIKAFSGKKEYLLRAHFGLSSFKGEPNDEKRPVTVEFEIPGQTVSGMVIKYLKVHEKSGYEVLPWVRYLTCSIKNSYEIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R982</accession>
    <name>A0A9Q0R982_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_10627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R982"/>
    <dbReference type="OMA" id="NHIFAFM"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000001">
        <property type="entry name" value="tRNA methyltransferase 10 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="7">
        <location>
            <begin position="96"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="333" mass="39228" checksum="D6C4F470652F2A14" modified="2023-09-13" version="1">MQNNNKNNNNFSLPNWLSSNDSKSLSKHAIKKLEKIQFQKQKQKEKKKRKKNQSKKIQNENQQKEQQNTTTPTKKDKQDHEEKGSQIEDEKLPRKISRKNRKKIPLSNFRIVIDCSFDELMSVFEIKKLTNQINMCYGANNKAEKPIKLYLAGLIGRTKAKLESTNGFLNWRIFYDEKKYQEIFKKDEIIYLTSESEEVLDEIYEDKVYIIGGLVDHNRLKGLTYEEAKKIGIKTAKLPIDQYLSMRSRKVLTVDQVFSIILNYINCKDWSQALIKAIPLRKGAKVKKDQNLKENQNLKQNQNENLNENENENENENQNQNQNQNKNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9H5</accession>
    <name>A0A9Q0R9H5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_09497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9H5"/>
    <dbReference type="OMA" id="MSDQEGW"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="97"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5072117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="302" mass="35649" checksum="24A91367EA6FDC73" modified="2023-09-13" version="1">MEKLIQKLNSQKDFNYKKVLHFLRKARKSKLRYSELIIKYGFPLIKNYSKKIDKEEYFEVLEQVYLAGLDCNKDASIFCIQILKEKFSTSLRFKILYGMFLESKGSFEKAKNLYGKILEKDSTNVLPQKRLVTIFKAQNDIPNAIKKLNQYLEVYMLDIEAWEELCELYLQTESYSKARFCLEELILLNPNESKYYDKCARVLYTIGGFDGLILARQYFSHSIKISKIVNPIDSYLGLLMTTNKIESLKKKTNQKFLELNNNLSKFAKEKLIETYQKQQENETQKENESIKTILDLIKDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9K3</accession>
    <name>A0A9Q0R9K3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9K3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="806" mass="95998" checksum="96654F58127AA8CF" modified="2023-09-13" version="1">MNQIIENFLFKFDQLENSLIEWKNQKSNSTKIILQNFLLIFKEFEDEKEIYNEEFKNKMIEMENSILEMISENIKQEDKDQELIEIELEIMKRIKNKEKIIDCVLGLSFLLKEKKFESEIVCEFLSLLKSLKIPNENPIWKDILISTRNNKWKIRKLSIQVILTNPEITKQNSNLIFQILELEENNNVKLEAIQAFRYFSAQQFQIEYLLLAIQDSNEEIQKISKNQLIHLLNQNEVQYKDYIYSEINRIFKKIITEFEKKPEIQANIQCIKILKSIFNCFGNNFDHTNLAVVYQAITKNISSYIHTEKNAVYDLVQEIAENVDFDVQIKWFHFICNFPKENIQNTAISFNTKPVENIIKEDDYHSIKKKYNIFTKKDDIWLINLILKYININKSTNSLLLLLLNCLNLLKIPNLRKFNKDFTLSDFYLRSLDTFYLLQKIVPILSEQILENEPLLFDFIDQCGTFCANNECKDILLWTDKTIKQIAQNLIFFTFANKNTDQNKKKNVVSLDFVAERYLLHLVSKLKNLEEDFSLGLLFQWFIRKTLSIQKKQELKVTILGVFLVFVSNYKLENKLIAVQILQNIINSSIDSNYRFLIKNFQNFPEVLKILEDRNDLNLLDLLRGNFIQFDKENDFVLNFFLENLLFCVIQLIDLIKLEPTTPEFSFLIKEWFHAIKHYENQEVALWNFMKFLPNILDKIGFIFLRYSKQFFPLISDLIHSKFSKILNQSLVSIEQIIEVKLSVIESFVLCCYPRIFFYKKQIQEFLNDLFLKNPKMDLKKIEEKKEEINILLEKTSSTLYIPQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBD5</accession>
    <name>A0A9Q0RBD5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_08277</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5074004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBD5"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="12">
        <location>
            <begin position="196"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5074004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="482" mass="55835" checksum="BA00FD5DC08B0644" modified="2023-09-13" version="1">MNKFLILFRWEMQPFVIPELISCCEMFDINFQIENKEKLINQGIQTPLLWINLPDEESAIKICSRAILIRAIYKIFSDSETFETLVEDLQKKSENEISEMMSNFNSYRIDVINSGKKLTQKHTVETIRKLSFIPFEANHKTVSLKNAEVNFVLINDFFDPEQPNNTSARSIKHVYFGRQISMGQGELKASYSLTERLYIGNTTMAPQLSFLVANQALAKPGTLIYDPFCGTASILISCSHFGSYVMGSDINYKILHAMINSRSKNVKRQKINLKNNKYTQKLSADQIPNIKNTFDQYKMLDRFLDISLVDFTHNCWRKQIEFDAIVCDPPYGLREGSKQLSENKKNLSDQEPTVRSSNYFPAKQQISIPSLIRFLIIFSAQHLKINGRLVFWLPTTSHFSYKDLPRHFCFEILAYSHQNITSNLVRRLITMKKVLDFDPNNSKHYKLINDIENLNQNQMKFKIKTKSKSKSKSKSKSKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD18</accession>
    <name>A0A9Q0RD18_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cathepsin l1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD18"/>
    <dbReference type="OMA" id="HGKTNNN"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000039">
        <property type="entry name" value="Cysteine proteinase 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040265812" evidence="3">
        <location>
            <begin position="22"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="5">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="107"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="324" mass="36671" checksum="75A4496227E54BA0" modified="2023-09-13" version="1">MKKFLILIFCFFLITTTFVQSKETKQKLFENFKKDFQKKYNLEEEKYRMKIFEENVKRIKEHNSRSETYKLGINEMSDLSAEEKREKYLLPMRRVVQEKKTHLKSTVPDSWDWRKNNSVTPVKDEGDCGSCWAFGTTGCVEGCVAKASGKLVSLSEQQLVDCDHTCFGCSGGLASKAFQWIIQNKGICSEAAYPYVAVQQTCKPCTVSASITSATQSAVQNEEALKENCYNFGPISVSFYVMDDFFNYKSGVYYNSKCPSDSTNYAALIVGYGYDSSSSLDYWILKNSWGTSWGISGYAWIARNKGGMCGIATDAWYLEGCQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDR3</accession>
    <name>A0A9Q0RDR3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDR3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19899" checksum="8B0F2E93741F59F0" modified="2023-09-13" version="1">MFQNTELYLQQQKREQSIGNKSVSYCMTIICIGAFIGPSLGVAYKDKDIGCSKPLWNWILVCNIVFAVSLFSSIIIPNSWAKFKIGFQIISNLFLLAWSIIGIVWATKCKDECGKLYEVALGDSITVLVLMSLTFFVICCCVVCCLPLINDINAIGDNSSEGFMSLLFLAIFFGLMAGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE71</accession>
    <name>A0A9Q0RE71_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE71"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="194"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="304" mass="36537" checksum="14403BE2E93BD407" modified="2023-09-13" version="1">MENKRRKEYDFVFKILLIGDCKVGKTIYFRGAHGILLVYDITNEESFQNIKKWIQEIKEYSDENIQIILIGNKYDFQKLFERKEFCDFEIECKDDQNPLKKIKIPIHKLIIQNRLKINENQITNELYSILSQNSQKEVDILLKWIYFGKVLFKDLSILKEWKNKLSNICKIEFETGIKSFLKDLEILMNSEETKDFQIISNNQEIKVHKIILITRSELYRGVFIISENKSNSVHEYSNKQTETIQSLIHFFYTDNIPKIENETIYEELKECVDYFQLNSERLIQIIPKIEKEKEKEKNKKIFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REB1</accession>
    <name>A0A9Q0REB1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NEDD8 carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_07124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REB1"/>
    <dbReference type="OMA" id="YDNIVSP"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000239">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5075554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="169" mass="20133" checksum="8F6D5A318E39BD41" modified="2023-09-13" version="1">MQKLIELKKERKQEPTKEEKQSQTREDRIQKDLQAIEKIEEVRIEFPEKEDFSHFKVIITPLEGFYKNGSFVFDFKIPQNYPVSPPKVFCETKIFHPNIDENGYPCLNILDREWNPILDLNSIIFGLIFMFLEPNPDDPDNRIAGELLRKDKDLFQKKVQEFIDENSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REE6</accession>
    <name>A0A9Q0REE6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REE6"/>
    <dbReference type="OrthoDB" id="10597918at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="456" mass="53968" checksum="0E9280A645DBF282" modified="2023-09-13" version="1">MKPIKKTKTVRIIYFVPKDKKPEKKYKKAIKFGIKDLQKWYNYHTYGYTFRLNEPIVEIIKGDHESKWYNETGNKENKTLNTWNNAVSETSRKFGSKHYDDNYAWVIYIDAEGGTGAGTASIACLPEHDLLGISGLHPKETSIWRWIGGLGHELGHAFFLPHSGEKDPESIMMYGYAKYPNCHLTFSDIERLRNSEFFFQTENQNDFIYPSYLFDSYVYSDGFFVLLDDKLNWEERKYTSNVVFKFEEVSRNENYIIIKDPSRNLMIQIPKKNGVSLIGSNNNWQNWVSLKEGFSYKNWEDQKKLIDQKIPHDSLIWKSVLDSNQQNVLNLFESFLYQNGYFIHLNSSFWQERNFEINPTVFRFQEILRDQKYILLFDHTRNFSIRMPISGGDSFISTDGSNWSFLYHVEKIGKINENENLNQNQNQNENENQNQNQNQNQNQNQNQNQNEICRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF36</accession>
    <name>A0A9Q0RF36_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_00598</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10"/>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF36"/>
    <dbReference type="OMA" id="EMISVHY"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000171">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5077278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="234" mass="26021" checksum="A24C040A89C976E8" modified="2023-09-13" version="1">MLKPKIAPSMLSCDFSQLGEEAIRMIDSGADYLHMDVMDGHFVNNLTFGAPVVNCLNNYLQKNTKKEYVLDCHLMVSNPEKWVEDFAKSGATIFTFHIEATENPSELIEKIKSNGMKVSIAIKPKTDVSIIFPFLDKLDMVLIMTVEPGFGGQSFMKDMMKKVEILREKLPNLDIQVDGGLSPKTIDFASKAGANVIVAGTSIFKSDDPAKTIQILKDSVQNNLIDKDKDKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFG4</accession>
    <name>A0A9Q0RFG4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBIQUITIN-40S ribosomal protein S27A-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFG4"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="305" mass="35318" checksum="0FEB6345B7248321" modified="2023-09-13" version="1">MKIYIKTLTGKTITLKVQPFDTTEKIKSKIQDKEGIPPDQQKLVFAGKLLKPGRTLNDYNIHKESTIQLILTLRRGDSCLPDMQFADMTKNAWKKKTFSKNVPDWRKACKGLNLEGKCTNQDCKAHNEWVIMHFGFGTFEMNSKNVLEKCICPICKELIQPEKPAFSTCKWRFEGITENGKIQTRSSDWQTIGNHYYVFHLEQSGISSWKSLTFYAERRNGYRIRNQNFNSNSKSNSNEDFNSNSNSNFNSNFNSNFNSNSNSNFNSNSNFNSNFNEDFNSNLIPKSKPKSKRKFQFTCHLKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFP9</accession>
    <name>A0A9Q0RFP9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000035">
        <property type="protein sequence ID" value="KAJ5079166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFP9"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="104" mass="12559" checksum="3A090F70D9801758" modified="2023-09-13" version="1">MRSELYRGMFLSVTEDKSNKVRDYSELSNKSFQIFEYWIYSNQIKEEIQITKEIIEELEIGIDYFQLNQTKSNLLSCSIDQYIKKKTQKKFKQKKEKKGSCFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFZ8</accession>
    <name>A0A9Q0RFZ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Btb/poz domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFZ8"/>
    <dbReference type="OMA" id="WPASITE"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="67981" checksum="AD4AA1A8894E1EC3" modified="2023-09-13" version="1">MNSLSKDLKNLLDNLDLVDMRFIINQTQIYAHKLVLAASSYFWKTQLFGNKTRNNEDIFTVVLSDIDPIIFKKIIEYLYTREILIDSKTVDLLMEYSSQFGIENLQHLCSEYYQNNLSSENCVKIHNLACKFKDENLKKISLKFLENHKLKENQVLKNSFLGMEKNDVTQLLLLNNLHGSEEIKLLAGIIEWSENYCSKLQMQTSPNSIQFVLEEPIKFIKFEYISAFHFLNLMHRKQYLTDFLVHKLIEYFNNSQLNDSIIKENVLQLEFMESKEKSVLERLILWGQHFCLDNNIDINQENLSKYISPFSSMLNFQAFTPTSLVQLLETKIFPFELILENLITNIQKLISSKTEYFIKSEKKPITSISEIKVLLIETNHFSRNDIISSIKSTGIQNVDSVDARNENVTFEQMKNYDCVFTFSYNSYKNPQEIGNALAIYVESGGGLVLAARDTLNTDDTCRIEGRIVSDGFLPMKYGKPIDDKPSFLGKILKNDHPILKNVKSFDGGECSYRIEGNATNGSSAVAFWNDGSVLVAEKTKQSNFGTVIVLNILPYSDKVCSNYWRSSSDGMTLIANSVVYVSRVEKNGQIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH32</accession>
    <name>A0A9Q0RH32_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH32"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="120" mass="14366" checksum="585A776E907CDEFA" modified="2023-09-13" version="1">MKILGRIQEKKFQIECGEGNQSLEWLIFTLITRYLFQKKIEKEIFGEFGSDFGNKINGKDIEFPLFIQTKNFYQKILIEETEIEKESKILGKEEKKRKIKEVLKEGESIKIILKFEEKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH79</accession>
    <name>A0A9Q0RH79_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000028">
        <property type="protein sequence ID" value="KAJ5079528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH79"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="316"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="510" mass="60119" checksum="7A3DBC0C09AA57BF" modified="2023-09-13" version="1">MEKEFSNTNKLVTNLKQLLDSKYLSDFVIFIHENTIENKKTQFNCHKSILSIRSEYFKGLLESKMKESQTGIANFYGITPNFFEDILNYIYTGKITLNQENTISIMIFASKYLFPELTKYCEEYLIEKVSIDTVASILDIAFQYKILNLHDFCLKFAISNFYQLVQSGYFYQLSGYHLQKILENDELIFDSEIDLFHNLIKWGNHNIKLYGDGDNLEKKETHSKLKSFVKLFKKIRFCDFDIKDIEKISSLNIINKKMMSDIDLYFKIREKLNNDRNIGKKERIEYQKQHEELTKRAQDKKWKIFCSRSRLKYKDTLITPEYLSCFKKWIGNEVFLSNLVLGYSAQRDGFSSFKFHQKCDNKGETIVIIKTKKGFIFGGYTKVGFSTNKKLWINDYVDYSSIEDPNAFLFQLANINGSSFWKFPIQIDKFQFAVYYNPNLGPSFGNISKRDFQVEKDMKTGWCHFGINYQVPKDLGIDLDIDLDGNFNYFLAGEIHFKIEEVQVFYLKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHB8</accession>
    <name>A0A9Q0RHB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHB8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040174298" evidence="7">
        <location>
            <begin position="23"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="152"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="905"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="939" mass="103067" checksum="278088AFF7AEA29A" modified="2023-09-13" version="1">MNQKLSFEIFLIFILIFKSFLCENQKLIKDSYFEQILIANDGKSNDNFGSSVSISENFSVIGASLANVGNNIYQGKAYIFGNSGINWKQTQILIANDGQENDNFGSRDNFGSSVSITGNTLIIGSPGATVGNNQEQGKAYIFGNNGTNWNQIQILISNDGQEYDSFGSSISISGNTLIIGAPNAKIASSSTQGKVYIFENNGTNWNQIQILNGMNGVNDYNFGTSVAISGSNIFVGSPNAFTSDDPCIGFISIFQKTQQSWNFKQILFPNDGEICWNFGSSISISENILIIGAPNYGCKENTEQSTAYMFENDGSNWIQKVKLSDPFGNNCDLFGSSVSISGNFSIFGSPWKNVAENQMQGKAYLFKGFPQIPSSHASGVSDTTTALIISLICLILIINIIVLIIYLRKRRRKKTQSQNQKSKKNSKKNSKKNLNEIEKETELKDLVSDENAKTKQNKINNNNNKETNINSEQIVIASDGQQYDNFGSSVSISGNFSIIGAPFADYGGNENQGKAYIFGNNETIWNQIQILIANDGNSNDNFGSSVSISGNISVIGSPHATVGNNENQGKAYIFGNNGTNWNQIQILIASDGKLGDNFGSSISITGNYLIIGAPFATVGKNETQGKAYIFENNGTNWNQIQILISKDGQSGDNFGSKGKAYIFENDGIYWNQNQILFANLDQVYEQFGSSVSISGNILLVGIPYTSFSGYINQGNTYIFENEGTNWNQKTKIVGSTAKSYSNFGSSVSISGNILIAGAPNKDFENHIGKGQAFIFQNDGVNWNQKSKLFDNTGNVDDGFGFSVSVSGDFSIIGAPWKDVGTNQDQGKVYICQGFPNSQNSNDSGFSKTQMIFLIIISILIVSAFVLCGIVYLHKKRTRFRNVFNAVYVNEDLFDEKENEFEKETELDELLSEDDRETSRLLDPNQNRNQNQNEIKTKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHD8</accession>
    <name>A0A9Q0RHD8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Grb10-interacting gyf protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000052">
        <property type="protein sequence ID" value="KAJ5078644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHD8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="450" mass="52997" checksum="DCEF7BD344A8A197" modified="2023-09-13" version="1">MGNKSPKPFYQETERGTTYQIFLPNLFIENINQKPTKIIKNHLKFMMKNFLFNSQNPLNCCKKFEEFLEKIKLEEKKISYSKQELLQLFIPNQKKPNTFIDIDGVTSIQPFEPVSFNKFKLLDNEIINSSIPILTRNEKYLESSFFMNSSPLISSTDFQKKQAQYLQNFNFTKNSIDNTQNIISSLSLKQKSPDKLFSKEKNQIQNQIQNPNSFQIQNQNQKIPFFPSIQLKENKWFYIDLSNSIQGPFSQSSMREFLENGLIFQKTLIKRINEEYFRSIDSIFPNLSNAFLNSSNLTENNNNNINKEKNNQSQLFPTNYSQILTQNPQNNQNQFFPNFSNFGRKNIIEKNQNQQNESINDLMNKIGFGNPLKSLRNQNSNPNSFPYSFPNNLDSSFYKEKSNFSNHYISNIQSQNFFLSPQKKPKRDDNNNNNNNNYYHFNLEKEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHI4</accession>
    <name>A0A9Q0RHI4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 123 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHI4"/>
    <dbReference type="OrthoDB" id="10265102at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025150">
        <property type="entry name" value="GH123_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041738">
        <property type="entry name" value="GG_III-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13320">
        <property type="entry name" value="GH123_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 123 catalytic" evidence="2">
        <location>
            <begin position="332"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="748" mass="84238" checksum="D3E223B68978CC33" modified="2023-09-13" version="1">MGVKCFACKIRTKAFLSTKKGKIITGTIGGGLLLILIIIIAVVASRKKSEDNPIVYDLIPAESSDYSYQLSNQIEGYPLFTVPVTEKVSRTMGAPTRVGNSSQQVISFFAAKNEYEHFKLIIGPGSGTYALSVQNFTSLGTDQKVQIRVASFDQTTGFEDTLTPVNSGETITLNPSLCTPIWITVYVPKTATGKQTYYSTFSIGSTNLQMQLYVYDFSIPEDFHFRTQVNIGVGSDAQMTELHDYRFTPKSATWPSSFKYTFTWETAASGDPICTNFYDESDQGVWGIHYLAGRYLNGTGWGGRKWTTAMGFQFVDNSTPRPSSFCGISRGSTHEGTEAYNTAWCQYLTALNNYLVENGFQDQVYYYVQNEPNDQAAWDLAHFLCNLTKHAAPNLRIAVSEEPTDKIIQSTGPDPCGYDIWISYIQAYKHKFAIQRQKATGEEVWFYSLDQDVEPYFNPMEIGYRGLHDRIIPWISWTMRSTGWAYYAFSRFYDSNSRPTVRAELLREGIEDYEYLYRANGNNQPQPGTPNAVDAVSFSVAKTLTDWFQPSFALQELKHQLGLYNEGSRATLPILIYNTTINPRGSYYINFQGSSPTADPLVYDGKTWIKMTWCNFDSTLGYGFYSTEMGQARTGYASTSHSVVENSFIYNDYGRLTLFLFALENGRYNVTISVGYPDRGYANDPHNAWVEGVKLIDDVVTTSVNSILTNSTIIDLNDGYLSLEFGGRSESIDDYAYTFMEYMMIEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHJ6</accession>
    <name>A0A9Q0RHJ6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cerebellar degeneration-related antigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="209"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="3">
        <location>
            <begin position="1343"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="3">
        <location>
            <begin position="1534"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1459"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="941"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1143"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1459"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1533"/>
            <end position="1544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1672" mass="194076" checksum="63CF8F4E693633A5" modified="2023-09-13" version="1">MDEIIFFGKNQYPKLIKNKPNKITKPIQFKFENENENENENENENQIKQISSGAFGAIFLFKNGKAIEYLNDYNSKNDFEKIQIENIQKVSVGSENIAILTSEGNVFGKGRYIYTTFGNEPNNVSSLIGDANDRIIQDVVCADATVYLLTLNQNAYGIGSNEYGQLGFDYDYDNNIFEESEKPILIMKNVSKIFSGNYSNHVFLLDLNHKLFGCGNNGHGQLGLRKKLKRSYTDKIFQIQNIPKGKIIDIQCGYGFSIMLIENQNQNPKRKLYSCGDYRYNGLDQNKNIYGFTEIKSFLFENDDYVIDFSVGQYHTLILTSKSKLIGFGGNFYGELGTGNTHNKSIPIQIELPKLRFNGDISNYHVLCGYQKSFLYYSPPSVSNLEADLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLRDENQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELINLCDNQEQNPQNKFTIFEVPSISITDYVERLRNYFRCSPQCFVNAIVYLFRILKQNSSIYLTKYNIHRFLLISLMSATKFLEDNFFDNKFYAAVGGVSLQEINKLEIEFLFLIDFQLVVSREEFIKVFQGILSFNDNLIISNFPKFPNSSNPSKFSNSLKRKKDQINFNGVIQNENSCSKFFQQKQQYKSKDKSNHELTPKSNKKNKSKDKSKDKSKDESNNKLTPKSNKKDKSKDKSKNELTPKSNKKDKKDKSKDKSNNELTPKSNKKNKSKDKSKDKSKDKSKNELTPKSNKKNKSKDKSNNKLTPKSNKKNKSKNKSKNKSKDKSKDKSKDKSKNKSKLKSKTESDSDSDSDSDSDSDSNSNSKSKLKSDLKSKTESDSDSDSDSDSDSDSNSKTDSKSNSKSNSDSDSDSNSKSKSKSKSKSNSKSNSKSNSKSDSELNQKKTSQFDLYFSADFDEPNENIIQNQNQTEKVEDQDISNTIIGQQANWEKTRIIAFGSYKKQLKIIEKEKEEFERQMMKKSEMEYNEFGNVDTLIEIIFQKQEKLKKRKTEKLERKKSEKLERKKSRKLKKKKSKKSKKSKSKSESESESKSKSESKSESNSESESESNSESETENSKIINEFMNKIKESQKEYSQIEKIEKKMQSINESKISNIDPTKIIYPPILSKKFCEKNGLCTNFFLKKYCDDPNCKHLHPKEFIRCPKIDSIEGCNDPNCEYQHPNPFNSDHLNFLSDEQLKNRNNIIIKIPFREMNKEECKKLGKSQQQESIKFKEYEKIPKGYKLRDPIEAEKFMIENIWEVQSENQTPPKITQIQIIENQYLYYRHSFLIEQAQSSNTFEGILWGFHGTTQNAVDPICRDGFLEKYQINNAYGKGTYFARNPNVSVGYSRGSHKMFLCRLCMVQSGYIYASGYLEKDSKKDLEKDSEKDSKKDSKKDSKKDSEKDSEKDSEKDLEKHSKKDSKKDSKKDLEKDSEKDSEIVNFNIKEQDHNNKNQLNSKIQSENQTPPKITQIQIIENQYLYYRHSFLIEQAQNLNIFEGILWGFHGTTQNAVDPICRDGFLVDFQYRDLYGKGTYFARNPNVSVDYCDDTKQMFLCRLYMIQSGYIYEKSCQYYIVPDVTQLRPFALIHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHJ9</accession>
    <name>A0A9Q0RHJ9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stealth protein CR4 conserved region 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHJ9"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003976">
        <property type="term" value="F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016256">
        <property type="term" value="P:N-glycan processing to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR4 conserved region 4" evidence="3">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="154" mass="18595" checksum="EC0444809E9B8D6A" modified="2023-09-13" version="1">MDLIEKRYSTKKNNLYEMREENEAVQGFVMVYSEIKDTREKLDEVIRNRPKFMCLNDDKNYSHPEAELVTEEVAEFLELFFPFPSQFELKDGETNQFLYLDEMIEFENQTTNQKKNHLIWLFIILIILIFVTPLVVVKIIRKNRNNLPIRVWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHM4</accession>
    <name>A0A9Q0RHM4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Straightjacket isoform c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000019">
        <property type="protein sequence ID" value="KAJ5079963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHM4"/>
    <dbReference type="OMA" id="ITDAMPN"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF108">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="95"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="472" mass="53714" checksum="73D1AB73455A6DC0" modified="2023-09-13" version="1">MGAGASGAKGIDNFRKALQESKIPNTSSITYHGLFYEYYFSTGEIETEKILSTKTMCSITENPVDPKKTEYHVALALKSKFDGEGIVKYGRPPLNLVFVLDISGSMSGGFYSQDKESEQRLSKLDIAKMSLKNLLKHMNDNDNFGLVVFDTEAEVIQELLPWKDIDKDKLNEKISALRPRGGTNMSEGITEAHYLIEQYYSKFKNEEKLSRENRIMFLTDAHPTTGDTSPTGLMGLTEKYSKEQIYVSFFGVGLDFNTDLVEQITNIVGANYFAILSSSDFRRKLDIEFDYIVTPIAFDVDVRVEGANIVNVYGAPGYDGTKKEHDGNIAKILTVMPSHINESQEIKGGTFLLELDDSVNDGLPFKVIMTYKDKFGKEYTEEHSGVFPSLQENQTQFFENLGVRKTVLLVRYVDFIKYLIKCQESNQNQTFSFNDEQKKEIQNFIDFMEKEKEELKDDQLDNEIQCLKDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5L7</accession>
    <name>A0A9Q0L5L7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13687</name>
        <name evidence="2" type="ORF">M0811_13707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000146">
        <property type="protein sequence ID" value="KAJ5066328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JAPDFW010000144">
        <property type="protein sequence ID" value="KAJ5066406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5L7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="178" mass="21122" checksum="BA1FEE4ACED37843" modified="2023-09-13" version="1">MMNKKDEKNESTNKEVESILTNQLPEKQNQEDDLKRKHNKTPEITPVKNLQPPQRSSTRELKKSHQNTKKKNKKNMSEEKEKETKSFVDQDLISRKLNFTSKNGDIEKNKVDEIESEKIDDKESFNKEDEYISDEQESSDEVDKKTPNKNESKKSKQRSKKKKRDKKRKEIKKKKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2024-10-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6H8</accession>
    <name>A0A9Q0L6H8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein furry</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2074" mass="241290" checksum="64431528D1DA27BA" modified="2023-09-13" version="1">MDKKSINIKTILSSMLLQFQTHLAKICELKLKEPPKKKKKSKKNDDQIKSKTWFNFPNNLPLYKIFSKSFVETGKNNFSVAISTISDFVPTFSQKEELLSYGFTSFLEKIWIDNLSNKQVDLLTCLVHLIFSDITLQLTQTVKKNQINIDNETGELLINLSIFFLKQSLFKNLPEDLRVHFENKIISNWCFIIHNISVFQFLQISDKFIKFIQEQKQLPTQKILNFLKAAQYINFKQASDSNLSTILIKYEELLFSFKKSAIRKSIIKLLESVISQINFSNNTHQTLFKIVKNIYKMILNLTKKKKKKDLMTSCYKLLTTILIHSLPEFFYSKVGKFIDGILLKNLTAEPLKKAMLSSIIRFLRGVSTVIVKRKNEEKNGEVEIELERESEVEKEEKEEDKEFIGQVNEYICIPQKRADIPNMDQYLKKIQIALFSPTMFDTPQLPQVISKISYIIVLIITNNYQMGPEIFNQIFNVSKKPELYLVGLIAYKILKTDIILKYMNSSFEYQFLSQAYSEMDEIVFKSLKKDLLILTEKNAGIETSANINKIYEFTSYFDKYEIYSFSRSWTETISNSSFLSVIPEKSKQIEAPTKLQMKTQENEKLRKKIEEEIYQVMNEWSQLQDQCRVPMWWGVADEESFKTIDSFTQIGITRKTRSLEKISMDQNSKFPNRSQLIWNQILQEIFDVLPLLPESNISKLLSVPEFIGKNVLHSNRRIAIKCSHSLQQILVQTINTPSVSCEILNQFLILIVKANYQVVQANYTLFSQLCGLLEIYQQCLQLNCRFELINSYLQSKKIFTNADAISLVYLCSYFPEIRHKCLYIVKTIKRIQQVIQSSYELDREVLDVNENAPFAIVNENENEKDNSKTDEKKPKKMSLNVSYKSSFLKRQTTKVPCLGDLLEEYNYAISQNVRYKAILELGNGGEVKSGFSRILPLISIEKAALSNQQKLWSLFISEIGHFVSQSKWFDVCNLVRNMTHRRLELFRDFVPEEMSTMMYHNWSHLYSLYFSILGTKAELIHISPPMRSLLSRVDLDRFDQTLKCPRSFFSEQKIGRNDGGYLDLPSDNSVYDLGLHWWSNFLISDENRRASFPFLAGYSLHYRGIYILMRALMDFVYRNHLAKSPWIFVPESSSFARIVAQNIMPSCIADTTQTLLDLLSFFLFAHLKFLFLLANSEHPEKIPFPTVNMTSYSPSDPLVLDTEFARFQSTESVTQLFHRIHASCMDSSPRGLHSVKILSHLIDIVLLITNIFTRMNLQKNHVENFSPRIQLRDRQELFHFLRICYSLTKQTIPDRISHISTGIKSVSTNQAIPQEMQISKYLDTLHKVTRKCFAELLSINSCFQDKSTIPFPFLLKLEDCGSPVLGFLLHNQLPLLMKDFVAYSLMLPNARLVSHTAEKYFYAICFQFEKYPDTNLDKFSTYLLLLALAKITSPLMETRQRACSLFSRVADSCLVDNKDAQISFHAEIKSLFEKICMPSTLQKLRKIGIEISRLACRFLRDKTPSVFTSAFKLSKSPNIDNETLLNILIPWCSVVILDNNTDFYVSYYNQKGILETIQRRNLSRENFLDNMWKFFQSTSFDSLVIPHSGLKLFSTLSKPQIPSHENKKSPNHPTSNLHHLLQFLFVKYAESSSSVIGELFINVFLKFPEETAQFFIDKLSLKIWNKSNEVVLTDFVEDLKTGYFGFVDPEHVENILFAEEDSDERKQEKLHHQAEDFSLAMNSYLAEKESTSFYRAIFSIIRKLLIFDKKSVLIEKIHFPLNYAILRIGVKCQRRIFDQELSDTILFVAEIFGFLLEHVQVNDPDQKEEIERLSKTVRFLKQLSGYSTVLFWVDLGKHQPQEELPEDLRSTHGKGFGYDSFISALRRALETNLLQSVLQKWGREAQKWSLYCVDSLLAICAMQVLAVLRSSLEINFVKTMMINIFFLLRCNNDYRTKTKTMLVKRFSERKKSNDKIMSIEHNSGNQLLYQTRFSSLVRVIKDLLDQDLRQTKHLRFPHLFWVSVLLMNLKDSPFSNIFEAAIDILSPASRIHLSNWRQIQRQHPQPLRNAWSLALIFPRSSSSSSQRFLLLFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6L1</accession>
    <name>A0A9Q0L6L1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Salt stress response/antifungal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6L1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040349687" evidence="3">
        <location>
            <begin position="22"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="493" mass="55398" checksum="AADB84F1B554CF99" modified="2023-09-13" version="1">MNNKIILITITILYIAFPTKQLDWNSTTYTLDGEYDQLDCAVNEDILLIRTAYAENSSNTWILLNTTTNETIASQNYEYLSMTQLSNLTTYNVYHTIALSKDYLVYAAYNNTTSNFGDDSNGTSVLKCIYNYTSPENITFEIAPDQGQNTKTFGQILAMYEDFLIVSDVDLNISSQFNSSVTIYQLNKTTYNFIQKMPTEEENNYIMFIPSMYGMSVSMNAEYLVVSSFRCVYIYQKNASLLYTKVFHACNLEFSISNFYGIPLSGIMPNNTVVAIKLNVSFDINFNPTAYFSTLAEFVYQDTNWTETYTKNLSTNPQTMQLTESIVLMGDPNANSTEGSIKDEFLSNGSFAVWDNQAEEWIFTALGKPDANFGARVSIKDNATCVTAPRGGYVVLYSVSTPAPSPSYNPSISHEPRPTKASDNTTTSSSNAKIIIIIVFASGIPVIVAVLIFMILYRKTHPKKSVPEKELLTDSEDSDNYQFDANDLDYHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6M3</accession>
    <name>A0A9Q0L6M3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6M3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040289837" evidence="3">
        <location>
            <begin position="21"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="804" mass="89749" checksum="CADB525E4FBC3693" modified="2023-09-13" version="1">MGFAFYFFLSFSLVFSLIQSQVQINQNMTLPASRGSGLVSFVDTEDGFVYFVEYTATSRLVKYNQTTLKVLDFLDLGIGYPASAGFDNNSKVLEKIQLSTNSYGIWRTEIDIINQMVYFGTDSPSYLVKVDCESFEEVGKITLPNDLIYGSVIDVSDGNLYVATESNSADNPIIHKIALSSFSIIANLTLNPTTDNKPSIGDADFEAGFIYFSSYTAPIHIVKIQISTFTKIDTLNLDTQENYTRGSVIDSTNHIGYFLTNTFPVYLVRVNLTTFLRIDSISFNINGAYIMCGDLELNKIYAFLVSASTGIANLEPFEVDSIVKDPYFCYARRILIDEPNQIAYILFGEVRNPIAKVDLQTFELVDFLILNMSGNSLNYGEIDSTNGFIYATSNHNFSIIKIRLSNFTFDSITDYSLYSTVYATTFDEETSILYVGIYNSTSTNHTIFKFSTPDLTIIDSFDFTVAHIYYLYKLIVDSPNEFIYIWFYNNSGDARYFLEKYNITNFNRIDGTNLTNWDVETMIFDKTHQYIYFGTDSGNSGYSNKLENIETTAYYAEICRIDLTNMAIPECNEIGGIYNFFTSFIESTNSWIFFMTTWLNSETGLNETKVIEIDSVLNQLISNTSFDYVFDRFIGKFDSSQNYEYGASYYADPTEILQLSVPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTPTQGESNSSNTAIVAVAIVIPVVVIAGVIIFIILLKKHKNKKIKEVVQKGEQEVTDKDGIQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7R3</accession>
    <name>A0A9Q0L7R3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphatidylserine synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_13463</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000139">
        <property type="protein sequence ID" value="KAJ5066608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7R3"/>
    <dbReference type="OMA" id="LPNFWEC"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5066608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="448" mass="52153" checksum="76433F62218CD700" modified="2023-09-13" version="1">MSNKNLQNKQQKQKGIDLKQEQVKVEEQQEKNKENDSKFTNPIIEHLLTPGGKITKEEYDNWAYRPHTITVIIILAILAIYFSMIHPVEDRLASYRVALAAGIIAFLVFSMLFFSDGILIRPHAYFWRLLKGMSVVFLIFNVFILFLSRDEARKVYKFIDPSLGVPLPEKSYATDCRIYTPEDPESKFKNVKEAFFDIFIIAHSTGWYGKALVIRDNLMLWVISILFEFLELTFQHMLENFKECWWDHIILDVFGCNLIGIVAGMWTCKILNMKSYDWTVKAKKSESKAVRAFSFFIPESWASYDWKIFSSPKRLLYWIGLVIILELVDINSFWIKYPLWIPPNNPLVYGRLIFWGFIGLAAVREYYEFATNPNVHRIGAQTWLCIGILIVETLQGIKFGKGLYPNPMPKVVKISWAIGLSVLTIGFTIHFTIQHYRQKNAKKVAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7R4</accession>
    <name>A0A9Q0L7R4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7R4"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040341798" description="PSI domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29331" checksum="CD3870BD02D4F4FB" modified="2023-09-13" version="1">MNLKSSVILFLQIFALIFYSKQSISPQNYEQITDDEICSQYTDCLNCVTHFADRVCGWCGTNSSCLHNESGLNCSDWYFGPHSLCPPDPHPSVYPVPTPSVSPTPVPVPFFRLECFSFYTDCFSCKQHYYDRSCGWCENVGLCYWGTESGPLPGACNSTDWSYGPNMSCVAPSPSPSSQPTPTSSHHSSHTVAILASTISGIVVLGLVTGIIVFFIRRKSHKSQIFEGKLYDREKSDPFKLNQVTKQRLITELDKSDNFNSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L825</accession>
    <name>A0A9Q0L825_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L825"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="283" mass="33877" checksum="66D684DF47EE6E5A" modified="2023-09-13" version="1">MQKLKSKSKWQKNENQNQIKKIKIKIKIKSKSKIKSKSKSKIKNQNQNQNLGIKIKIKIKIKIKIKIKIKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIENQNQNENIHDDFVQFSLLFQEIFKYWNPYESNLQIQQESQFEKYFKIEEINQAISRNEAHPINFIQFILNILNNSKNILKEINQNINLTPTPTPTPNINTNINQNQNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNLTQLQLQLQLQLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8H9</accession>
    <name>A0A9Q0L8H9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of chromosome condensation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8H9"/>
    <dbReference type="OMA" id="VDTYEFT"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41016" checksum="E80F349202947D82" modified="2023-09-13" version="1">MNEIIFFGLNENPKLIKNEPIKITKPIQFKFENENENENEKQIKQISSCEFSTIFLFKNGKAIEYLNENNSKQNPEKIQIEENIQKVTVGFSNEAILTIEGNIQNDRIIQDIVSGYQSIYLLTSNQNVYGIGYNQFSQLGFDSDLLLKTEKPILMMKNVSKIFSGNYSFSVFLLNSNQELFGCGSNYNGQIGLGESRKEETKIQKLTKIQNIPKGKIIDIQCGSSHSIMLIENENQNQNPKRKLYSCGNWQYNGLDVDTYEFTEIKSSLFKNENDNILDFSVGDSHTLILTSNSKLIGFGLNNFSQLGTGDTNNQSIPIQIELPKLRFNENISIIIFLVNLKNHFFIILLLLFPILKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8N9</accession>
    <name>A0A9Q0L8N9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8N9"/>
    <dbReference type="OMA" id="CIDECTI"/>
    <dbReference type="OrthoDB" id="10628400at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="705" mass="80729" checksum="02F7C365CDB82DD6" modified="2023-09-13" version="1">MNLSIFNEPNNWNYNLTLNSEDILIDSIGRKWNIENPIKIQIEKKSQLFFPLSFKTNFQNAFQISNNISNDNCPNDCFCCESQCFSLSQNDSIFYLFDIFSPLLIWTTKIHVNQQDKIWDLNLEIGGEQKNINNSISAQIKSDNLNPIYSQFENFFLAIQSENLSLDNEPFLIPKNEFNNSVNKIGISKEKYIEKQTCPPKDLISVMNGSIHNQLSKFQNNFISSQIGCYFNQNLSSLDPLKSSTFSESFICDNISSDFIQITMEIGSTGLSFTKEIPQIKVIDSGIQFINQTSGILFIDVENEAIYNGTIEIQPRNCCLNNLKKTEDETGSEFIVDCSAIQIGSSISKSITSKEVINFRFNLNSNSTIDQEGNCTYAILQNGRLDSVHEIGFGTNDPNDIFSKGFVMNSNNPICTSPSREVTLGGAIRYCQPACTEDQEFNETTQSCIPVNCSSKYFTSENKRDFYNPQTGLCEPFKECSGNEILNYISNVCLDSNTNNNSQYVETWSDFEAEDVYTGNISDFLNNTYADCGSHGKLTEDNTSCICDKGFTNGLDSNGVFQWCRNQIPNLDTQKPSVFQSLNWSLIGITFGLILCCVFCCCRKRIYRCCCRKKRKIVKLQKMKNNEKEKLIWLILKMKELESNNFWKRFSSLNDLEMNSNFNQKKKIKFKNQFKPNHLQNNSKPKMKNLRDFQKKKMEFSQFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8R8</accession>
    <name>A0A9Q0L8R8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase II subunit beta</fullName>
            <shortName evidence="2">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8R8"/>
    <dbReference type="OMA" id="QYLLMTY"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="223" mass="25998" checksum="3316255C1D2C05B3" modified="2023-09-13" version="1">MSIEQEQPKQIINENQPVSWVSWFCSLKGNEFFCQVDESYINDNFNLTGLSSQIPYYNYAISVIRDEEIEDLDDLTEEQQEVIESAAEMLYGLIHSRYILTPSGLQAMAKKFQNAEFGKCPHFYCEKQPCLPVGQSESLRQDTVKLFCPRCQEIYFPKLARHSNIDGAYFGTTFPHFFLKVFPQFKPKPLLQKYTPQIFGFRLHKSVRNRKTVPKPKTKTNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L957</accession>
    <name>A0A9Q0L957_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000120">
        <property type="protein sequence ID" value="KAJ5068140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L957"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="442" mass="50743" checksum="D642C8883F9B8566" modified="2023-09-13" version="1">MNEILFFGRNQFPSLFKKKPNKITNPIQFKFENENENKNKKQIKQISSGSYATIFLFKNGKAIEYLNKDDSKQNPSKIQIENIQKVTVGSLNEAILTIEGNVFAKGYNINPENPYEFINISSLIEDINDRIIQDIVSGAYSIYLLTSNKNVYGIGSNLSGQLGFDSKALEKTEEPILMMKNVSKIFSGIDSYSVFLLNSNHELFGCGSNSYAQLGLGESRKEETKIQKLTKIQNIPKGKIIDIKCGFIHSIMLIENENQNQNQKRKLYSCGRYRSNGLGKEYQNTYEFTEIKLFLFENDNILEISVGSYHTLILTSKGKLIGFGNNDYAQLGTSYTKFKSIPIQIKLPKLRFNENISNYHISCGMFKSFLYYSPSFSNLEEDLIKLFERKEFCDISFKTKNGEIIKAHKLILKYRLNQNQIEIEKLKEIISKKSIQRIKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9F6</accession>
    <name>A0A9Q0L9F6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-phosphatidylinositol 45-bisphosphate phosphodiesterase delta-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9F6"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="475" mass="55516" checksum="F312F6CCBFE2A581" modified="2023-09-13" version="1">MSKILIEAVLELQNPKLTQISNKKSHWKSYYFVLTEKSLQYFNKKNKKLLGEIQIKQSKLIPHENQDFFVIELLIESKNPIFIKFESKKYLENWIQIMTSMKDKPDIQVIQSQIEKLNSNLKVLLVSNVRLLKILKMHSSQSVDIFLLVFVEDTQQHTQFLQFYENSNLETFPDKSIELSTLKKFSLFELLDHTSGIKLELIPTGESIVLFQDSTETQQWLTLLQQKKRKSRLSQNIELPNQENNEQNNTNINIDSNTNSNTKEEPFIKLKKIKKYTIKLPAAPTEPPILTSQEKMRLHQLFQNLSETNHVFGTQVREAFQAFLQTNSNDEKSNSLEQIMWNEHEYLLEIKKFVTKGVLMNKVRPNGKIHQRKFWIGNEGKTVFWSRPKIVGKKMKKISVSNIQQIIDGVETLIMKKAAKSKSFNRELSFSIISKDRGGDFVASSIQEKNFWVAFLKSLTKNCLEKNEDPFNFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9S4</accession>
    <name>A0A9Q0L9S4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9S4"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="270"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="320"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="487"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="585" mass="66859" checksum="C5DB636CB941772B" modified="2023-09-13" version="1">MEPILYNNFAWGFNQNKQLGMKTNNTKQPVPIPLEIFEDGYIKQISATIYSTTFLGSNYEIILSGSIVNDCEKQPIKNAPNFEYICSSSDDFLGITKEGHVYSWGRIGLEKSKQLQQNDKTFFYEIECFKRKVCVCIACGASNLYVVLENGDLYTKGYDSFEVIKKSKSIFGSNSSKKQKKKNPKEFLKILQNVKKVFSGNDSHALFAITKDEKLLAGGTNTYGQLGTGDFQEAKKPTEIKNLPFKVNQIIDIQCGYYQSLMLSSVDGIGKVYSTGDRLDNGLGLSKNTCKFTLIRDLENENIISIGCGSSHSLALSQKNELFVWGKNTGYSELGFDSSESIEKPKRLIIPNLNKENILKVFGGPLNSFLYSYPQFSLVVDFQLLFEREECVDSSFIFLNGKKDVHSLIFSMRIGDQKTQALRQILENTDKEIGEKVLQWVYYGGFNNECVDILKQIGFTDQEIREKSGYLGLQKDLQKLYLQQNSKDFTIISKNQPIKVHKVVLLARSDLFRGMFINVNDSSNQVNDYTERDPETIRIFIEYLYNNKLRKKLDPKTVEELIDIDEYYQLNSPDHFKKELEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA46</accession>
    <name>A0A9Q0LA46_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rap gtpase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA46"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="201"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="426" mass="50543" checksum="6EA7CB6689D5CCAF" modified="2023-09-13" version="1">MNDKKILNSRKQKRKQINDTQYKFDDDEFIQVIGYQDNIQNDSLDIEIVKEHKKNNYKFLFLKGSQNWIIEEVFCNEKKKLKPISNEKTFTNHFSGKEYYHFVSKHPQKGYTSICIQETTEEKEKEQEQENKEEIYKIFVLYKENHEFHVVKKNDLNVSFFRNLFCMGPSISKVIETFDSSFKNVEIFTCNQNDQEDEKSLVSIEKSKSIYQFKFGVVYVKDGQTTEEEILSNNKGSREFNEFLQILGEKVELFHFDHYRGGLDTKHNFSGKYSFFTTWNEMEIMFHVSTLIPTSTTEINNPQIEKKRHIGNDIVVILFLDGKDLFNPETFISKQNHVLIAVRPLKNLNLKERNYIIQTARKESVPEFEPYFPDPPIIPKRDLRDYLLAKACFGERTTTNSGVFKDRFKNYVESTLKSLYEKYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB51</accession>
    <name>A0A9Q0LB51_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ef-hand protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB51"/>
    <dbReference type="OMA" id="EIMTAKM"/>
    <dbReference type="OrthoDB" id="435273at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="149" mass="17539" checksum="A6D082FAB84AA7EE" modified="2023-09-13" version="1">MNEFSEQQIQEIQQPFKLYDFDMDGNITPNEIGVVLRSLGLPPSESEIEKIKSKYEKTQKISFDEFLLIYKNILAKKPEYDNQFQRAVGWLDKNKSGFIEIKELKRLLTSIGEPITEEEFNNFFKEFAQNKDGKISVEDFKKLFLVNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC36</accession>
    <name>A0A9Q0LC36_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Atp-binding cassette sub-family d member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_02204</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF59">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER ABCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="734"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="521"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="693"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1123"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5069634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1346" mass="157599" checksum="ABF98D3603E270AA" modified="2023-09-13" version="1">MNLFIYQFCQKKEDQETNPIYLTQMSFSSFYEEMKKKFPDIPLQNWVKRSQSNTTFPVVFRISVKKFYEENERNKENYFEKLPKKIKSELFKFEKPNQMKFYGNCPNRIGESKNELRSLEVIYYGFVSIEENLNQNQNQNQNQNLNSNQNQNLNQNQNQNENENENQNQNQNQNQNQNQNQNQNQNQNENENENQNSNQNQNQNQNQNQNQNQNQNQNSNQNQNQNQNQNLNQNQNMTFIVKERGNFTLNSLQHMTLSIKSKNREIEQMILDYEKKEPKNFSTGSPLLMFFNGITTAQFSGGFRLIYEAFFPEEFPIEKVRKLTLLIHKQNESLELLSPIVYEFLTEEKMQPFLENLQDIFQKSQISVIQLFQSFPTFQICQDFLGLFQNQELTNIQISVKDGIVSAHQEILKLRLESYYEKTIKTLKKFTKFEAENFLGHFVYSGIDVDLIPDGIFYKEIYRSQPFYSNFGYNYLSKEQYQAILDLVKEIGFDSDWIKRKKGRSGILKDLNLLYSNESNKDFTLISNGVSIKAHKIILFARSNLFRGMFLSVNDSSDLVHDLSSKSSDSISALIRYIYLDEFDSSSLNIDQIFELEDLVEYYQLGFSSLNSPVDSFNFSFMKDNQNQKYEKLLESTDSDFDLNCFTEEKQLNSKAKEKSRKPEEVYKFNIKFIKRFFQLIYYINKPRSYLKIVLIFLLLGASLGNQILGYHVGKLASNYYEVLLDKDLSQFKHLILLSFWMVFAIAIILVLQTFFAEILAVVWRQKLTSQLQEEMLINRRAYQIIILDNRIDNPDQRITQDVDRFSTTSTTVMSQMIAVPFIIIWYTIKSFMELSWIGISVFYGLFLLASISNQTFLTKIVNYVFQREKLEGDFRFAHVTIRKNIESITLFRGNTYDKLTVNEILQNLINIQKKIVFRHIPLNFSVNFFNYVFAIIVYIVIGVLIFSHHFLNNSSDSAQISKHISLSSFYYLSLCNGFTQLFNLSTQLSELAGYVGRIAQLREILNEYSLNEQRKIKSANNDFLLSLSEKSQSSESSDENPQIPYQIQSKNSQIEKNQIKKIQENSLDFSDSSDSIFNLLNDSEKPKYNDPIDKEEINQNEVQTLNSKQSNPFQIIRIKEKIELQNVDCQTPDGLLLIKRLSFTVSSPDNTLLITGPSGCGKSSLIRIIGGLWKPKSGKISRPKINYKNLMVLSQISYIPYGSIRDQVSYPIKLESDDFKYNHHICKILHKVKLFHIIKRHCNGRTEEEINKALNHISNWDSQLSPGEKQRLSLARAIFHRPLFLILDESTSAIDSLTETQIYNQFIKLKIPFISIGHNESLRQFHRRNLIIHSDHSWEIVDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC37</accession>
    <name>A0A9Q0LC37_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein furry</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="127"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="730"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="1162"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1477"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1519" mass="177912" checksum="6E72AAB80022518C" modified="2023-09-13" version="1">MDVRESSHYIIQSIFTQFTSIAKSLIQNLSKMNKERKPYYTTIQNHLEFQRCIDSLSNLGKNCIENIMTGIITWREEILGTPNETNETNDKKKLKKPKTKLHTVDISFLNNLGIGNSKLSQIIVITETIFSVASLRVLKYTQQTLSNKLLDKIIKVPLSQLIDFESEQQQITEPKDLIDQQKLNELCEELIGELSKQNIKSVVKIFFTGQETKTITPTMAQIQHIKLTNKDQVTVDFNAHFVESFLNVLKKLDRRSKRKLARCGAKIFQKFIDNNYFRDFDFTDWFLNIRNLYNMTAQLGEKASELQHYLPLQTALLCCSDKAFFFEKHKEFIELSLKSLKNKSIRFVSLECVSNFLRFYMTKFVDPNPERVAKNIEKIALTIFSFNRKMTFNVFSPSISATPDEMILFISDWKLSYAMNFIIFKLIESDNSEWVLIGVRTFFALLEKNPQKQSNRRISDPTTLESFVQTCQEKLEKVFTYYDNQVGNFIQSAPQLKSPIEPILKEKSKEIDILIYAIKSIPRVLPFPNKLLEMISKYTIHFDQNLSSISFEAMKRIIANQSEIRLDLLNAFGKFILQIPDNFVSIIQSSLQKLLELILLWVNILKQSKPNTFLHLNSQEFSNNSSQLILSKIYEKKPVFRNDEETIDSSHKESIDSLSQSQFPQINSQNDIDNENIRQIEKQSDNDGNDQILENFKNGMDDQIQMNIKEKSSSKNLNKILDFTSFFPEVSRLESVLLVFLSSTDPKVRRYSLQNLENIRKLVTCHQTIYPEFFQQESLTAKINSVRVIQIFEESRSRVTQNIYHPNKLMTREELLKPKRFLSQNHNLEEFICGSKTQDKFKWTIYLCQLLKRLTISKQHICSLTFKEIFSRLKSINDAISSKIQQRKKLGLITKQIEKFICYSMIAASIAHPSYVSIEDCKLFFRILSPFFLHKTEMLCNGFSQSNEKIFPNLISGFDPLIQQILNEKEKKGKKHKNRELTHICIIYRTFADLLEQESFEDTPFFQTHFLKIIQKISSYVDSPALVDSTDILILRYHLALFVSRYSSLMELSDRLIDRNDRRFLWKLFAKYCGLGDQTVINQMKAKLTLFLREHHRDPQQKESIRKNFEEQSVSVQFACLKAMSSLLYGEFFDDQINQVVDTVFTHIFELLHSQNKSIQSIGTISMRKFLTRNLGKLFPIYFEQSYSIDTKKASAFTISLVEAFIRDEVDVSISEALVLVLYKLGYYDQLIRKSISDLLKYLSIKLNKSGQNLPVILSQFYTIQENYRDSQFKLSALLASRYPELAYRMFGEFSKRYWQVNRQIKVDPTKIHLIEENKSILLRLLTPWLKKMVCNNEDEVIAKNFTEVLESLFKITSRDSNKHSILIQKTWGAITYHSSNLGICFRFLVYKGIILSQISKNDFRSFWVFMKQISVYIYRESGSKIVQYFFKKLQLLTHKKKFLQQQELDQNFIAEKSPQIQEKKLDNKQNLTNGEKTNKNDKIIKTEDEQNEKENENEKNEKNENEKEKNENENENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCH3</accession>
    <name>A0A9Q0LCH3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_11561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000104">
        <property type="protein sequence ID" value="KAJ5069390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCH3"/>
    <dbReference type="OMA" id="WRAAYHN"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000023">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="182"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="235"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5069390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="338" mass="37236" checksum="436A06F0DFF9CAB9" modified="2023-09-13" version="1">MSTIPIEIISSLIPSLSETFHKGSMGRIAVIGGSTLYTGGPYFAGITALKIGADLVHIFCTKNAGTAIKSYSPDLIVHPILMSEEEIKNEIAKSKLRNEEETAEGIEKKIVENITSWLDKLGGLIIGPGLGRDPKVINQVEKIILSAKEKKVPMVIDADGLFIITQNKELIKGNENVIITPNKMEFWRLQNSLFPEEKQEPNPKENPKKVFDLQKEMENVKKMSEKLGNVTVLKKGFNDIISNGKNTRICNFLGSSRRVSGQGDILSGAIGVFLNWFNLDSPKKSQINKEIGIPIVAGYAGCLITRKCNSLAFSKKKRSMTTSDMISEVGIAFESFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCL5</accession>
    <name>A0A9Q0LCL5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCL5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="455" mass="53905" checksum="ACBF6B824FCE2799" modified="2023-09-13" version="1">METYAQILYILISIIYFIFFILTLTRWILLLKRIKQLLHQKIFFFLIWLFFLSRFITLLLFTIPKIGSNYESQLNQSLGFETNLLVTAFLLIVFTLNQIRIKKFTENYDNEKKKKKIFISIFIIIDIILISIHIWLVFYNYQVSRWFICLSFVIVSIGFLIYSVKLSKNSEYQKQSKKFLIIFVICTICFLIRIPILIMAKVKADSFTKEQIYISYIVYLIITELIPVSLITFSMFSVPIKPKQANFYTKKFITLLLFTIPKIDSNYSFQLNQSLEIETNALVTAFLLIIFTLNQIRIKKFTENYDNEKKKKKIFISIFIIIDIILISIHIWLVFYNYQVSTWFLCLSFIIVSIGFLIYSVKLSKNSEYPKQSKKFLIIFVICTICFLIRIPILIIWKFKKGTITREQTDISYTVYLIISELIPVGLITFSMFSVPIKPIVMNSLDLKLLKTDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCR8</accession>
    <name>A0A9Q0LCR8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCR8"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="462"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="583" mass="67203" checksum="B78622CFE5915F63" modified="2023-09-13" version="1">MSILVTEIKNDKENIPSPRCYVYSFIYNNKIHYFGGVNDSSQRYNNILTFDLKEKKWGEIPTTGTPPTERSDATCCVYDDYFYVFSGYDGNICSDFYQFDLLTNNWKKIPLFGEPEIFKRCSSGSHLFDGKLYIFAGELDGMMKNNIFYIDLKNFQIVPIDSKPFQPSNRSYISSVEYDSKLWFCGINSIFLSSHDFMVVFDLKTNSWIELKTKSEEINSNKGKSSSEIELSEYSLNGRPSKIILKDVDSENQPSTYAQTSVIVGDELFIIGGMPITELNLFSFNFSECEWSKKKILASPSIGRLAFHTSVYDPISGCIYNFGGATNFSGNWERNNNFICVHLGSDIQKDLKQLLLLGTLSDAQIQSNDNHIFPVHKLMFYCRVKNIQFEYIAQKCKKYSRNVVWNFLLYIYTGLIEENPPELIELAHFCNLESFENLALKFEENNTLIEDLENLYHDEITKDFTITSNSNIIRVHKMIMAARSDLYRGMLTSVIDSSNTAPDLSNRSTPALIHFIHFLYTGSIDHIDDFDIAQEIQGLSGYYGLRNDNLDDFLQHFISKSDLEKKRELRLFQINQELNLNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDA7</accession>
    <name>A0A9Q0LDA7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lissencephaly-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000108">
        <property type="protein sequence ID" value="KAJ5069170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDA7"/>
    <dbReference type="OMA" id="NVMHPLK"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="249" mass="28379" checksum="7BB00C35B10C5C62" modified="2023-09-13" version="1">MAVKYHPVFSLVCYTVSEDEDATKIWDIESGEMIESVKGHTNIVQDIDWNEDGHEHNVSGVAFVPKKPQVISCSRDNTIKLWDFSTGLCLFTFEDHDDWVRRVAVNSDGTIFASCSNDKTARIWDLASNKCISVLSGHENVVECLAFSPQTTNEFIEIKHEKFTFINNPFLATGSRDKSIRIWNLETKECVLILSGHENWVRSIVFHPCGKFLISVSDDRSIKIWDLSNSRCIRTINDAHDHFVQALKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDU1</accession>
    <name>A0A9Q0LDU1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucosamine-6-phosphate deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGL family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDU1"/>
    <dbReference type="OMA" id="THRVCLK"/>
    <dbReference type="OrthoDB" id="10057450at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052960">
        <property type="entry name" value="GlcN6P_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002557">
        <property type="entry name" value="PRK02122.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42892">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE DEAMINASE-LIKE PROTEIN BT_0258-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42892:SF1">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="616" mass="70853" checksum="C013950C774C98CF" modified="2023-09-13" version="1">MSHFKEYLKPTIFQTDEEIVQAVVQKIKALLESKKEKIVLGLPTGSTPLGVYQELVRLHKEENLDLSRLVTFNLDEYFPMDSKNPQSYTSYMFKHLFDHINIDKKNIHIPNGMIGEDVINEYCQEYEKQIEEAGGLDLVLLGIGRSGHIGFNEPGSFFDSRTRLVVLDETTRRDAAGGFFGIEKVPKLAITMGIGTILSSKEIILLATGEHKALIVKQLIEEKASRKIPATFLHSHPNTHIFLDSSSAGELSRIKRPWLIKEIVWNNLMKKRAVVYVSQKLKKAILELDTADYFENFLHRLIHKYEDNADLVSLSVFEDLNQKILYPSKLLKNERIIFFSPHPDDDVICCGGMMYKLNQMNQVTVAYMTNGSVSVPDSHAIKEIRLMKGITEIDPKLIEIEKSLEKPEKNKEKELDSEMLQKLKTKVRETEALSAIEQLNYSIKQARFLDLPFYKTGGIKKKAISNRDYEIVLNLFEEILPTHIFVAGDLTDPHGTHRKCYDIINKAFQIFSQKYSDDPVKKPPIIWLYRGAWEEFPIEEVDAFLPLSKSDLELKVDAILKHQSQKDRAMFPGVDSREFWQRARDRNLETARLLSEIGLPKFFAIEAFQIKKQFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE26</accession>
    <name>A0A9Q0LE26_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Btb/poz domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE26"/>
    <dbReference type="OrthoDB" id="7492888at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="302"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="505" mass="60138" checksum="3D4D5EC54EF40947" modified="2023-09-13" version="1">METYLNLEKLSNDLKNLFQNQKKKESYFDFEIICEQNKTSFKTHKSILSSRSKYFKSLFNSKMKEFQENKLVLQDVSSSILSSILSYFYSGKIEFNLENAIQILFFSSKYLIDELIGIASNFIKNNLQFETVVDILKLSESMNFNQLIDSSYQFILENFEEFIKTSHFLELEENHLNSILSNDEIFINEFELFQSIIKWGKHKSNIIQEKEKENQKLDKKDKEKLQIQISNVIQKIRFIDFSKQELKDTLKEDLIPNQISQRLNDFQKLQNQKNETKRNQFIENQNSLIFKTRKGTNFKSTIAREKEYITKLKEWINDNEFFFKMKKGYSAKRDGFDCKKWHDICDDKGKTLVIIKTEDNFIFGGFTQVGFTSDKTKWNDEDQNEEDGYIFDSNAFIFSLRNDKNDREPKKFPIRTTEKRYALFYNYSQYGPYFGDGDFIINSNMKSGSSEFGLSYKIPETLDQNVDEAESYLAGSYNKWKIEEIECFSFKKTNYFFFIFFIFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEC8</accession>
    <name>A0A9Q0LEC8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEC8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="474"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5071163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="555" mass="64513" checksum="35C734894FAE3396" modified="2023-09-13" version="1">MKIKIENENENENENENENENENENENENEKQIKQISSGNFGTIFLFKNGKAIEYLKDSKQNPEKIQIENIQKVTVGWRSEAILTKERNVFAKGEDINPENPNELINISSLIEDTNDRIIQDIVSGSNSIYLLTSNQNAYGIGSNRYDQLSFDSKTLPKTEKPILMMKNVSKIFSGNSSDHVFLLNSNQELFGCGDNGNGQLGLGESRKEETIQKLTKIQNIPKGKIIDIQCGIDHSIMLIENENENQNPKKKLYSCGNYKHKGIGKTENNYEFTEIKSTLFENDDNILDFSVGYAHTLILTSNEKLIGFGYNSSGELGTGDINNQLIPIQIKLPKLRFNQDISNYHVSSGYNNSFLYYSPFLSPFSNLEEDLIKLFRRKEFCDISFKTKNGEIISAHKLILQTIIGQEDQIEKLREIISKKSIKESNQIFEMIYSNRIINPKLYSEIEQEFNLFFPIEEIMKRIYGNENENEKDFIIERKEKQYKFPKLILIMRSELYRRMFLSIKNDKSNKVTDKNELSDKSFQIFEYWIYSNQIKDEIQITQRMIREIKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LET0</accession>
    <name>A0A9Q0LET0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">snRNA-activating protein complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_10829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LET0"/>
    <dbReference type="OMA" id="QYESTHI"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="161"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="249"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="306"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="306"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="361"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="361"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="362"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="409"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="413"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5070560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="545" mass="65478" checksum="DC6F2051E221C9D8" modified="2023-09-13" version="1">MFSQNLLSPDEIFQHDTIGISLPENNNLIELDDQNNPLNPIEKDKKIQDQFNEVLELNNKFREILEEKIEEISKNIQLLQTQQETLNVYSRKQKFNNKEPFPNNLTESEELISDYDHMTKWSPVRTSFVDRSGIQPPDNEDKKMLKKYLLKRHPKFTLCKKWSNNEDYQLTEIVKEQILLNLATNLLKEWNEKDYKKAILIEKSFMELKNQPDELIFSNTKEIDWDLVSKYVVNRTPESCMLHWHHVLSPLICHDKWTQHELDSLSEIANRHNARNWIMISQEQYESTHIRRTVSQCFTVYQRYLASKFQRFPWTQEEDELLIRLYNKFPKRWTKIAEFIPNRNAQQCLHRYGKRISPTIKKKQKWTFEEDSKLVLAMKIYGKNWALITKHLPGRSDLQCRERFTLVLNPTIKKGKWEMKELELFIEGVKKYHPPNWSKISTIVKSRSNKDCRSKWVHMEAHPEKFPIQIISQLSEFSENIKKFLNEQNDEKKEEKENDEKEKNSLKRRKKNQNKSNKSNKKKSNKKKSKKKKSNKKKQKQNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEX0</accession>
    <name>A0A9Q0LEX0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000091">
        <property type="protein sequence ID" value="KAJ5071119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEX0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="171" mass="20851" checksum="9D132D35D22BADCE" modified="2023-09-13" version="1">MSTELFSKFSSFSSSFQEYRTEINSILIKIQNFTDTFNKKNPKNIHLITNKNPEINEFMKLLQDLKEIVEKYQKFVTTLDFLRETEKNQQKQIQSKQIQISQLENHFLKKKQNDDSFLKFFEFETLGVDYDYFQSKQEFIYHEKFCKLSNRFFIFVIIFVIMFFLIIFLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LF48</accession>
    <name>A0A9Q0LF48_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LF48"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040236893" evidence="2">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="195" mass="22134" checksum="C1922E921B5693E7" modified="2023-09-13" version="1">MRNRIFVLLLIFQFILLFANSDGNQNGNQILVGNDYYFFGTEKEKVVYFPLKTSVADDLTIKVFGSTCDFRLYFRSGVIPPDPTPNFQLYPGFSLKSDGCQASVSLSKNQVYDDSETFQILYYSTLNTTDSYFSINVQLDYDGDVYAKAKAGLVISIILLSIALLITIIIVIFLARWKKKKKPPESEPLLEQDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFB3</accession>
    <name>A0A9Q0LFB3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger cchc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFB3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="409" mass="47573" checksum="FD837D5AA03212D8" modified="2023-09-13" version="1">MIFFFFLLYILSLAFFLITFHRFTVVLSLFTSRKNRMQKAKNSEERIKQLPQESLKKIQNEIFARRSGLPESILWLGVPLSVSFLEPERSRKKKSEIYIVVSLAIVYFTGFYAPLLLPNALFLAFISYSLLKAYKPLKYKVSELYGISNYRIFISGSKDDRKVIEPFRFWPISSISNIKVEPKNQDTFTVFIYFSNDPRICEICNISNPEFLLSILQTSNQTNGNVDSNSNQNSNQNSNQNSNQNSNQNSNQNSNQNSNQNSNQNSNQNQNSNQNALYPIDDILIENDENYFVPQLDSKSISNSNQKQNQNLYPNLNQNQNQNQNQNLSNQFPANPFFFSNQNSFFQQPFYYRPIPIPSQFQNLNQNQNQNQNQNQNQNQNSKSKSKSKSKFISKFKSKSKSKYSRTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFJ9</accession>
    <name>A0A9Q0LFJ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFJ9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="268"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="489"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="594" mass="69270" checksum="2D6BBA72C695ACD7" modified="2023-09-13" version="1">MNDCIFFGDNNYPKLFKNEQNEIKKPIQFKFENENENENEKQIKQISSGNYSTIFLFKNGKAIEHLNENYSKQNSKKIQIEENIQKVTVGVGNEAILTKEGNVFAKEKDINPKNPKEFINISSLIEDKNDRIIEDIVSGHNSIYLLTSNQNAYGIGANFNGQLGFDSKTLKKTEKPILMMKNVSKIFSGNTSQHVFLLNPNQELFGCGLNIYGQLGLGESRKEEKRIKKLTKIQNIPKGKIIDIQCGNIYSIMLIENQNQNENRNPKRKLYSCGRCDYNGLGKNEDEDTYEFTEIKSSLFENDDILDFSVGNTHTLILTSNSKLIGFGNNSYGQLGTGDTKSQRIPIQIELPELRFNEEIFNYHISCGYYKSFLYYSPSSFSNIEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEDIQITQEIIDEIKIGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFL9</accession>
    <name>A0A9Q0LFL9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pleckstrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_01395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFL9"/>
    <dbReference type="OrthoDB" id="70570at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051765">
        <property type="entry name" value="PH_domain-containing_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280:SF3">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="7"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="347"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="467"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="568"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5072381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="669" mass="79219" checksum="A047212BD51985B4" modified="2023-09-13" version="1">MQEAKTLRQKKTKKIHQISRIFINNIDILIRNYLRPLEKNPIIQTQDQILSKEDLLSIFRNIKQITILVAEFLYKIEYLLMTWEKDYKFGDLFVNLKNRIEEFFTFQNSQKKAQQTLTYCESNPKFVSYCQNIQNKNSSEGYSMKELLDLALYFPFVLNKYSKKLLLVTDEDHPDHQKIEEFIHNLDQNLSKIFQEEKKQKKKEAIEYFKKIQKIQKIYRKSQNIEQTPIQINSNQNQNQNPNPNPNQNSNQNQNQNQNQNLNQNQNQNQNLNLIQESKENSDQIESKKEKSKDFDLSNISNTNILENSKIEKKTSFKQIRENTNELHESSKKIIAKIRKKVNQEREIIYEGPIHKISRKKKEKRHLILCNDIIVVAGYSLISKKKLTIHWVFELDQIKTCDSNEFIENIPNSFSIKTPSKSFIVMIDQPEEKMKWISKINKQVNKVRKEKGVQNLERQEAPIWIPDDQVNECAICHSKFSLVKRRHHCRNCGNIICGNCSPNKCSLPNISTTPKRVCNLCLGNIKKKKAFDEKFKNMKESQTESLKESPRRKKTIFVPVFETQKILIPKSPQKEMKRENKKEMKKEIKKENKKEIKKEKPISSPKRKKFNDKSKSKSDGFNQFQLQQQIEQELKTKTKPKTKQNIRQNANVNSRQLVRSFSSNSYRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGB8</accession>
    <name>A0A9Q0LGB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras and ef-hand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGB8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="310"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="776"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="893" mass="106738" checksum="B938F3946CA6E388" modified="2023-09-13" version="1">MQNKKEKYDFLFRILMLGDSGVGKTSLWKRYCDNFFTDKYTFNVGADFKTKKIEIEGKIIQLQIWDVAGQARYRTITSSYFRAAKGVLLVYDITNQNSLRNINGYWMEEIKEFTDENLQIILIGNKNDLEEKRIISKEKGKEFADKLQIPFYEVSVKNNINIDDAFYHLTTNILENIDEDENIIKYSIQNDFKQLFERKELCDFEIECKDAQNPFNKIKIPIHKLIIQNRLKINENQIKNELYSILLQNSEKEVNILLEWIYFGKVLYSNLSILKEWKNKLSNICEIEFKRGTKSFLKDLEILMNSEETKDFQIISNKKKIKVHKIILLARSELYRGMFINVTEDKTNQVHEYSNKQLKTIQSLIHFFYTDKLPKIEKSKIYEELKECVDYFQLNSTRLIQIIQKIENEKEIQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQNQNQNQNQNQKKCYDYDFLFKILFIGDYRVGKTSLWKRYCDNKFGDYDLSVDFKIKMIEIEGKIIKLQIWDTSGQERFRPIPSAYYRAVHGIILVYDITNKDSFNNINNFWIEEIKKYANENLQIILIGNKNDLEEKRIISKEEGEDFTDELQIPFYEVSAKNNINIDDAFFHLATNILENLGKDSQLKTRINERNKYTIQEDFKQLFERKELCDFEIECKDDQNPFNKIKIPIHKLIIQNRLKINENQIKNELYSILLQNSEKEVNILLEWIYFGKVLYSNLSILKEWKNKLSNIICEIEFKTGTKSFLKDLEILMNSEETKDFQIISNNQIIKVHKIILLTRSELYRGMFINVTEDKTNQVHEYSNKELKTIQSLIHFFYTDELPKIEKSKIYEELKECVDYFQLNSTRLIQIIQKIEKEIQNQNQNQNQNQKKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGW6</accession>
    <name>A0A9Q0LGW6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGW6"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="40"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="18019" checksum="BF057D1E8339DD5D" modified="2023-09-13" version="1">MTKPSKKSTMQQTAEEAKEYLSPDKSKSKKKKGTKQGDKPKKKRKGAPRSVKAGLEFPVGRIHRHLREGKFANRVGAGAPVYLAAVLEYLTAEVLELAGNAAIDHGKQRVVPRHIHLAIKSDRELNKFLNGVTIHGGGIIPRAIPVLPKKIQDKKGKPGFSQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH61</accession>
    <name>A0A9Q0LH61_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein mtl1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH61"/>
    <dbReference type="OrthoDB" id="6142248at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA ligase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="415" mass="49322" checksum="CBE1B82193B45D70" modified="2023-09-13" version="1">MEFPIFYPYEQVLDENFISKLKEYKDEIDKTTWIVTEKVHGSNFCIVTDGNNIRFAKRGEFLNENEDFFNYKNLDPNIIQKIFNIYQILKKKFQNIAYVYIYGELFGGFYPTISSKSFISPVQIGIYYSPEIEFYAFDIGIKFNNENQIQNENENQNINQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIENQNQNQNQNKIQNQNQNQNQNQNQNQNQNQNQRKKQFIENIKIIENMLTKKRQKNELTFLKYTESVKIFESVGLFHAEILFEGSFDEAINYPIGFQSQISTKLGFKNLDDNKAEGVVIKGNESIYLPLFKNFFRVAIKKKIPDFEERKYNLTENYYLTKILNDSGINEETKSMFIELDSFITNQRLTNSIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHB4</accession>
    <name>A0A9Q0LHB4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-protein ligase e3a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHB4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="501"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="70686" checksum="8A44B0205B5C7F0E" modified="2023-09-13" version="1">MNDCLFFGRNKNPILIKNESDKIKKPIQFKFENENENENENENENENEKQIKQISTSYFSTIFLFKNGKAIEYLNNSKQNPQKIQIEENIQKVTVGFQNEAILTIEGNVFAKGMNINPKNPKEFINISSLIEDKNDRIIQDIVSGIGSIYLLTSNQNAYGIGLNNFGQLGFDFKTLYKTEKPILMMKNVSKIFSGNYSNHVILNSNQELFVCGYNKYGQLGLGESRKEEEKIHKLTKIQNIPKGKIIDIQYGWAHSIMLIEDENENENENENENENQNPKRKLYSCGDYEYNGLGKNRDTYEFTEIKSSLFENDDDIILDFSVGNFHTLILTSKSKLIGFGDNLFGELGNGDTNNQLIPIQIELPKLRFNENISNYHVSCGYYNSFLYYSSLSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIQITQEIIDELETGIDYFQLNQTNPNLFDLLIKKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHX5</accession>
    <name>A0A9Q0LHX5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-a2-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_09928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHX5"/>
    <dbReference type="OMA" id="DYKFIGM"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="185"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="278"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="282"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="410" mass="48825" checksum="B16421BD95BED11C" modified="2023-09-13" version="1">MNLLFRKTSLKFLFQNFNGKKNKTKKQIENSKKPIENSKKMLEKIKQEKKNKHKIKKTVQNKKETKENLNVSNIEENKENNGKKKEQKPKHKRQIKKTKFRLFKTKRNEEEKQKEEQQKVEQKEEKEQIRDIDKQYSDNPLMVTEYVQNIFENMQKEENSLQGSKDYFEKIQTQINPLMRKILINWISEICNEYNLHSETLYLAVNYIDRFLSKNNITKRKLQLIGITCLFIASKYEEIYPPDLDEFVDLCAGTYSREEVLDCEIKLCNSLEFKLTALTAKHFLRRFIIASEYDFKLVLLANYLCELQLLEYTFIQFSPSIIAASCVALSNLITKKTNVFDSTLEFYSNHKLIELKSCMFELLKLFRQASSQKFNFPFKKYSKEEMHQVSQIELDPNLDVFFSEIGMNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIM9</accession>
    <name>A0A9Q0LIM9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIM9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4704" evidence="1">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="468" mass="55791" checksum="76114036A541BEE0" modified="2023-09-13" version="1">MESTDTSKSKIIKNPFIFETISQLFIQIPKLIDIQILDNLFNLLKENNSNKEQIISQFGWQQWLISLLHIDIQESKKYSINQENNFGNNNQNQNQNSEQDDLNSIISENENQKEIQNKNDLNEIIFKILNILLTYSFLNSFYNFPEIFEQFISSVYLINFSSKEKIPKIIQKVLNDIILNIIKNTNQNDKMIQQKQQQQIFDQSFTILSNIQNISKEKTLNNLFYLIQVLNVVIFNPSNDQFQFYNPEKKENKFIQTTVSKQFSTITKNNQKQQNSNIMENFFEFGKKIEIFEKEIVKNLIILLKEYEFFEKKGIQFEKKDEKKITYKIIVFLILFTIPKSDVELTKFLVSKLNYLIKQLNSRNKLFKYSKELIKICSSFLFSYIQNQNQNQIQNQNQNQNQNQIQNQIQNQIENERKVKRNTLLSFLQVLMQENYNFLFQLFSSQNKKNSLLPKEYANSFIFSLQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIP5</accession>
    <name>A0A9Q0LIP5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Grip-1 associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIP5"/>
    <dbReference type="OMA" id="YDEACLK"/>
    <dbReference type="OrthoDB" id="5583482at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="383" mass="45195" checksum="9630F6168E7BB2D6" modified="2023-09-13" version="1">MIQAEKLSLESLVEELKKKIDSNSTSEQVNQTLITNLENEKAKLIETNEKQSIQLKKNQETISNLENSISQNNLNSKNETQSLNNLIENQKNEILDLKEKIIQNEKTFQEKEQNLNQNQSSLLDELKAVQESEHNLSEEKEKILQEIEKLKNENESKIEKEENFQKEIEELNKQIEICNWKIQDGLTERKISERKSLEIIKDLKAQLRKEKKKNSNSNKNKDKETLNQEIKSEKEKPKEKPKEKILTKSQSLTNFQVQKLNIDNKNQEHVLDIEEINEKYKILEEKNFKLQEQILILNEQIEKKSNVIQHFLIKEKSGVFNAKSRSKRNSKLNSELVSQMQILLEENILKNIQLQQHIDILGKEIDRLLQEQRKKESKEKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLF6</accession>
    <name>A0A9Q0LLF6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLF6"/>
    <dbReference type="OMA" id="MGFGMQP"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="315" mass="35741" checksum="F7985138C4868969" modified="2023-09-13" version="1">MSTTPIHVKLIEAKGLKSADIGGKSDPYATVSINGVRPFHKTKIQKATLDPVWNEAFELKVKDPNKDLVLIGISDWDRIGAHDLLAFIRLPISQFLDRKVHDIWRDCEGRKPGTKEKGKVHMLVHYLPEGMPFEQDKKTIQPQITIQQQPQVQYQQPQVTIQQQPQVQQQPQVQYQQPQVQQQPQVQYQQPQITVDQMAQQQFQQQPQQQMGFGMQPQMGFGMQQQQPQMGFGMQPQQQMGFGMQPQMGFGMQQQQPQMGFGMQPQMGFGMQPQQPQMNFGMDNGMGFGMGGFGLAVTGFGSPHHKKHKKKTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM79</accession>
    <name>A0A9Q0LM79_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho-type guanine nucleotide exchange factor isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_06948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM79"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="328" mass="37946" checksum="31D582947F9D9F05" modified="2023-09-13" version="1">MDTLYCVAIEDNISRDSKSLSFQRNQRIVITRIENNGWYQGVSNGEVGTFHSSKVRLITSTLKDTETNQLQQQQQQTLVPPIKPLTSKTSNLSLNTTTTENTNEKPSQNSPNPENSKMEFFGFKLRSPSTLGSFNTTNVPQREIKNNSNRKENPIEKLLKPDKNENQNENENENQNENQNENENQNEIEDDEDVQPFQNLEQLMNKMTITNENKTKQNENQEITNDNQPKEKEKEKEKEKEAKISTNQSQKNPSNPKIQSVTQKRINPSLTPQWERLANLQLDVESEKERCSTLNNDITSQEQFLVSFSQQINSHLEKLSRIKTYLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMN6</accession>
    <name>A0A9Q0LMN6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMN6"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="445" mass="49657" checksum="E25E234BA9E2EDD3" modified="2023-09-13" version="1">MNHRKLVHISMSLFALLIGRFSNTLITISCIIAFISNIIIFPKFGRLFEDEKDKKLGFPVGILTYPAILTIISVIFFQRQIFLSIGWGMLAFGDGFCGLLAHKWSYFYNNYKLPWNPNKSLSGMLFFFFFGFSLTTLLVFLLPPEIRLFLYPNLRYFHWIITIFITSIICAFVETIPNFFDDNLVVPLTGSFASFLIMEFLDHGKFQTENSFMIGFLVVVVFGVLSYFSKKIDFIGTVVGSIIAMLMYLGGGFASLNLLIIFFVGGSLATQWKISEKRKMEVAEKKKGKRTFSHALCNAGTAAMCGFLACAFPEKKMFFLTMLAGSMSSAMGDTLSSELGNLYGSHFWNILNFRNDKRGLDGVVSPEGSLAGVFGSFLIAFVFSFGFRNQLDNVFLAFFKVFLAGIVGNITDSVLGASLQRIGLMSNHSVNLANTIVGALMVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMS7</accession>
    <name>A0A9Q0LMS7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMS7"/>
    <dbReference type="OMA" id="FACQRNP"/>
    <dbReference type="OrthoDB" id="10249694at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="735"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="820" mass="95482" checksum="D9F4C788E3D76F8D" modified="2023-09-13" version="1">MNIFEIISNKEISKLKEIKNISEKETKEKIKIIKFAFQKKVPKEIIEILISKGIPINLKDKKRRNLLHIAIKNKSEIEIIEYLISKGIDINEKTFYGQTVLHYACQKNSIQVIEYLIEKGIDINAKANQNQSALHYACKKNSIEVIKYLIERGSDINSKTFYGQTVLHYACQKNSIQVIKYLIEKGIDINAKTNYNETVLHYACQKNSIQIIKYLIEKGIDINAKTNYNETVLHFACKSTPSIEVIKYLIEKGIDINAKTNQNQSALHFACQSNSSLEVIEYLISKGIDINAQTNWNQTALHFACKRSFSFEIIDYLISKGADVHAKTNFNQTVLHFACENNPSLEIIEYLISKGADINEKTYQDEKTALHFACQKNSIEIIKYLIEKGADINAKTEMNETPLHFACQRNPSVETIQYLIKKGADINAKTDRDQTALHYACRNTALEVIEYLISKGIDINAKTEMNETPLHFACQRNPSVETIQYLIKKGADINAKTNKNETALHYACRNTALEVIEYLISKGIDINTKTNQNETALSISIKNSNEKIIKILLQNEVDIYDLQENEIKKEFIDSFIQIYSLNHDFNNLLNSEDNFSDFTIKTIDGFKFKVHKLILLTRFDNNNLILQKFIDNCYHKTKEEIKFIINFIYTGFPDFEKIIEILNQQMNKNQNKNLNRYFYRGREFKEEKRILKEIEENENKIKEFFKEIGIEIENKKGRKGIIKDLSKLYKENETKDFIIISEEKEIKVHKLILFTRSELFKGMFLSVSDSSNQVHDYSRKSNESIQQLIYFLYHDKFEENEINSKIIEEVEEFYQKFFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMW3</accession>
    <name>A0A9Q0LMW3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19599at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1292"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2257" mass="267737" checksum="455C9228D93F0F30" modified="2023-09-13" version="1">MEITIDQFQKFITTVKKEKDTWFNIILYSISFLYQEKLTKNIESKGNEDLSIDQILSKVKSEWEKLIRYLNKDPNLEYINTELPIAKEEYLDKDYKNFKKYNEQNQSEQKKFITKKTKNRIQQFFEFRKIINRINPLIKFCEIFIQNKNDEELSNIKNWQQNWKQNKLSEITKLKKKIEKTLKVNIQILDLINDLFPNQDEKDQTIIKWIKEELKEKTIDNLKKEIQNQDIINDDDLNQTKKYLINFIDIFNPFFTKKFQDFDSITKQLSKIQKEMEEKIKKTNFKLLVKNFPLFKEQNIKELSDILSDKIEKIFKNGSKIIFRLEEPIFQCQINEEKEILNFEDFISMWRVALNKKNKSQNYNQFDEYPTKYKESPLLRQFELLFETIQSINTYLKKFIPIKYYKQIPGINKEIEINEDDDSYSEKMEELEKNIKQTLKNWEEDSKNISKEKLSGILSTNQLLLVSTPLLNIQEKNKVIYPILKLIFGKGRSVSQEILNNIIHNQTDNWINYSTGFFYLIKNNFTWPIIKNSLKKIKIKSITKLSNELIKQINKRDGNISNPKIFIKEVKTDSFIHNEVTMIYYLYSNYLPQRGQILFCDSNTIVGDVKNFFSIYKYYNEQYSNFKKQKQEEEEKVIFSIINATLLSQKCQSEVISQIRSINFITHFPLTIFVLEGEQNAFLMSQLQEGKLIINLENDLILNEIIKKSTFFKNFKVFYSQNEGDGKSYQIRKFCNSQNDKIDYKYYLIQLTTGEIQELIVELNKIPIEKKNENEELFIHIEFPTECSLQMTDSLWQLSMWGSIEDRQAKDPYNICWTLPPNAKLFFEIPSQNNIWKYFYPLQKFQPQECSCSVNEIKFKMYEVDEDQKKIQEIDDNDLKKVANLLIETQNNTLFNNFQNLDNWKQKLSTQNPDPNSFFNKSQYIIQTISNQLNPNHNFHKSFRLFYQFWNSLKKFINLILNWEISDDEDDEDDEDDEDDSQQISFIRRQEIIRCWMFSVARLNLISFFSTKEGVFDKFYSFILNLEFQNGNPISIYNPNISGSMKEVGLFIKDNFDKSNLLEFERNLHFQSISDPNFNLGDSISNNVNDLKTEYKKMLDFFSFLTSNKPQENENSDNESSDDENDNNNNKENNENDTRKGKYVLTFDNLSKMMFIQFRMFTEFSLIISGETGCGKTALIEYLFRDILNYQFSKFNSEEELNEKEKETNHFITFNVNGGTTKEKIKKLLEKSQKIGKQNQVILFFDELNTAPKYCIPIFKYLFIDRLFEGKKIPSNIKFIAAINPYRERKSKAISENQNNENQNNKDQNKENQNKEEEVCGLLFDYGDKKNKEQEEIRNAVYPVHKIPNSLENSVLSFESLKSTQEQVYILKMVDNTFYSILNNNDKKFREYQPIRSTFKEYISKSHSYIRKDGDSNQTNDDFKRNLAALISLRDVSRTLRVFQWLVESKAGRFLLSENEQEEEEELFQKAIYLSLFVCYASRQTTNKDKYFETIFERNDNLFGNCKNVIDNSQEKLIESLDYDFSKKIIAKNLYLKENCLLIFVCVYAQIPLFIIGKPGTSKLISVEVIMESLKPPHEINNFAKKLELRTLRESFLQFALAELSPDLPLKALHSQLEESEKEISRINQDNKKIQDIIKENGGVSVVAISDWVLDPSNTNRGILLRRESIAQLGTTAQQILCTKTVGMNSMIPKIFANYLTKIYEKIVKEQEKDPKSKSRPYFGLRDFYYFLKMIGYCNIKHGISYNNPGLILNALLRNFSSKPDFIEKLIPKFPKKVLLITDIKITTRELIYQNINRRIFQEFGFEDTNDTPNYSRNMMILTDKICNLSFILKEIEQLSTKTDYKLFFGSDFAENKKQSRIIRNLQLIEDSIHNGEIVILFKNEQLYEPLYDLLNQNYSKEGYDIYAKISFGNIVSKIRIDPRFRLIVISDKSRAYNIESPAILNRFEKYLLISEEFIIKNEFIQFYQKQKEIIQNICKFADITEEKLLVSYHPDLLPSLATKLQQILFGKEPKEKEDYLRVEGVNMWMRICNYESILSIYLKTIKKDTNKNIKEISYLKHIWQRYSGLYHHNLNDLIQKTLIPKQIQCSVVLTSSSISQEIKSEQIQNFKFEEIELLKIENDTQFEKEVKKKLGIEPIIKKNPYKDDENFVLIIRFTPTSIFPEIIFHQSKYMIENLIKKDEYKSRKDEGIKCKIIFIVHLPSIQQSKTQFHFAFEKNWEYFYIDDILQSEIKFTIISESKDSDLNFLENILDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNS5</accession>
    <name>A0A9Q0LNS5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_07841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNS5"/>
    <dbReference type="OMA" id="AICAMRI"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5074798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="653" mass="74614" checksum="A19A34D6F1883762" modified="2023-09-13" version="1">MSLTLKDLIRGVRACKTAAQIRELIATESAKIRTFFRNEDTKYRPRNVIKALYMHMIGFPSSFAQLECLKLIATESFICKKIGYLGLSMLLEEESDILVLATNVMRNDLISGNSLFISLALTALGNLATEDMARDLAPEVEKLIHHKDAFIRKKSILTAGRIIRKVPDTLDRFIGCVRNLLTDKSHAVVLATLSLMKSMIEVDPETIEKFKKFTKGLCKILQTLSETAHSPEYNVAGIVDPYLQISILQLLQIFGKDDKEKTQLMTDILAKIANSVQSSNVGNAVLYETVMTILLIESEKRSQLMAISILSKFLSKNSNNLRYVALNTLSRVVDKVPNAIQRQRKTIVNCLHDSDISIRRRALDLVFSLVNQKNAKTLIKELMNYMLESNQELRNDLTSKICLAIEKLNGDKQWQLETLIEVLEVAGQYVSEEIAAKTINLIIEYSELQSFVVHKFFSLLNVERDRPQKLIQVAVWCIGEFGDLLTEEIEHFEAIPSEQVVDLLEFLLVNTNVEYIKYYLITSLIKLTTRFPDQAPKIQDIFSRYRTNVDIEIQQRSCEFYEFFKYGDFSISVLDKIPPISALLDESNETETDSQTDSQTESQSEVIKEDQKSSKLQQKKLVQEPKKSKKQQQKSKQQNQNQNQKSKNSRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNS6</accession>
    <name>A0A9Q0LNS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nodal modulator 1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_06772</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNS6"/>
    <dbReference type="OMA" id="FVFKGFG"/>
    <dbReference type="OrthoDB" id="10263633at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055075">
        <property type="entry name" value="NOMO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055074">
        <property type="entry name" value="NOMO1-3_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055073">
        <property type="entry name" value="NOMO1-like_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056190">
        <property type="entry name" value="NOMO_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056319">
        <property type="entry name" value="NOMO_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056187">
        <property type="entry name" value="NOMO_8th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051417">
        <property type="entry name" value="SDr/BOS_complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303:SF14">
        <property type="entry name" value="BOS COMPLEX SUBUNIT NOMO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303">
        <property type="entry name" value="CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23141">
        <property type="entry name" value="Ig_NOMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22898">
        <property type="entry name" value="NOMO1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22904">
        <property type="entry name" value="NOMO1-like_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22902">
        <property type="entry name" value="NOMO1-like_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23194">
        <property type="entry name" value="NOMO_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23660">
        <property type="entry name" value="NOMO_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49478">
        <property type="entry name" value="Cna protein B-type domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040467286" evidence="8">
        <location>
            <begin position="20"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1153"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like N-terminal beta-sandwich" evidence="9">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO second beta-sandwich" evidence="11">
        <location>
            <begin position="119"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO fifth transthyretin-like" evidence="13">
        <location>
            <begin position="410"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO second beta-sandwich" evidence="11">
        <location>
            <begin position="517"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO seventh transthyretin-like" evidence="12">
        <location>
            <begin position="603"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO eighth prealbumin-like" evidence="14">
        <location>
            <begin position="671"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like ninth beta-sandwich" evidence="10">
        <location>
            <begin position="773"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5075910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1230" mass="141068" checksum="0ACD7568D8E14209" modified="2023-09-13" version="1">MKIIQILFLSFFLIFLINSQDSIKGCGGFIKISNELKNLIKTIDLTEISIELYNTDTNFLKEKQNCAPNGYYFIPIYEAKGDFILTVKGPEGWSFVPNEFKVTISDEINTCENDINFEFSGLEITGKVESTCDNCEKGVKGINVNLIQNERIIRTSKTNEKGIYTFKNLLPDKYSFEIDKSTFPNSWIFDIDMIKDYQIDFINHNVNKPLTIKRFSIEGKVLDSEQNLENNKIANAKFILFTTKEMIEKNGFKIENEIKTIKEEEIEYFPILTTESDLNGLFTFSEIPCGDYVIIPVSIPFQLEPNFKKISVVNNVFDAGNFKVLGFTAVGYVKNKGGSPISNVLITINGKETAITNEEGQFKFGNLQKGNFQIKAQKNHFYFDNELTKNIILSPSNYQIQDIIAVGYDLCGTIKLQNNQELKRKINLQMIDSHERKFTQITDNKGEYCFKVISGEEYTIQPILTQKEIENGFSLNSITVFPIQVQNEPIFNIDFIQTILSISGKINCILSNCFDLKIKVILKENSKQISQETFINKDGSFVIDNVIPGNYKIRVDEETFCWENEEYPVQIETENIANIVFQQKGFLLKAQSSNSFIAECEILSFSQDSETIAKIPIQFNQGLNLICLEKWGLYRIKPDDCFLFEKEEYFYNYQKSRNEVIDFKLTHIKVEGILEIEEKEENLNEIQIDIKTIKTKTSDEGEITDTKTQTIFAQAQSSSKPSSYQFTHYAKIDSKTIYIPKSKSLLFYPKNQEIENLNGQECPIKLRIFEGKKGKFITGKITPALEDVRIIIKNEAEKEEYETKTDSKGKYKYGPVEDPGKYQISAIKAGYVFTEEAEKGMFRFRKLGSIKIKIEDKKEGNKPVSNVLLSLSSSSGYRSNNIVGVDGTFLYQNLEPGEYYLSVMLKEYDFTPSSGLIKVEEGKDVDFSIEAFKVAFSLFGSITTLNNKPITGLTIRAESQNLKEIHQEETQSNSNGNYRIRGLKPNVNYLISVMKKSSSQKIIPNQISVHIDQSDVSNLNFIGFDNKNNLSQIIGIVNSSYINNITIELVPKLDSIKKEMEKKNFPMKVHPIPLSLNQSFFYFPNVLYGNYSVILNTDLSRNEYTFDKNPQIEIIINENENEKLFGNLSLNDLIQFDFYPKNLDNSQFNSSSYSPFISLFFLLLLAISVIAGLNYKITLEFYKNYQQSKSFKISFQKIWKKNQTKIDDSNDFLNHKHFGRTKINKGKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNV3</accession>
    <name>A0A9Q0LNV3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_06817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNV3"/>
    <dbReference type="OMA" id="FYVMARF"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="54"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="449" mass="51174" checksum="57FD20FEA19C0C4B" modified="2023-09-13" version="1">MQIDQEEKYTKEKETEKSQFDPSKWIRSQYQNLQMSSTLAINQRSAELESQGRKVYRFGFGQSPFPVPERIVKKLQKNAFQNKYTSVEGIKELRQTIAKFESMQKTQDPTFYSENNVIIAPGSKLNMVDLMMILKCTTLITTPAWVSYAKQAQILDLPIEYIHTSFEDDYKIKPQILQEKLSKINGTVLLILNAPNNPTGQSYSKQELEELSVVLKKHPVIVLADEIYSFLSFDNDYHSIAEFCPERTIISSGISKGFGAGGWRLGYLVFPEQLSFLIKPIQSLASEVFSSTSSPIQYSAVSIFSSLHKLSEYLDKSIIILRSIANFGYKTFTKAKIRTVFPNGGFYFYIDFENFRTSLESNNIKGSQSLCEHILQDANVALLAAKNFNRDINELAARLAFVDFDGKLALDNFSYDHVQKNGFLTDSFLREFCGKTIEGFEKLANWVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPM3</accession>
    <name>A0A9Q0LPM3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho guanine nucleotide exchange factor at 64c isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPM3"/>
    <dbReference type="OMA" id="NIFHNIE"/>
    <dbReference type="OrthoDB" id="7415582at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF263">
        <property type="entry name" value="PLECKSTRIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="254"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="454"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="562" mass="66209" checksum="D146FDAF9203A692" modified="2023-09-13" version="1">MDVLNSIFAFSTLTTKQKKTFDPLPQPHLLLFHKGNANVSFDIDNISSQNCVKGDLIYIPSKYGFDIESNDDNETCILSIPLRNVPKKDIYAKPYFFDNDTAFFDEFFTYETNNYLTQLKINEKEITFETKENYHLIFIKSGKLKFSPIFAFIQNQNENTNQDSNQDSTNFQMNEIGNLTLFAPNTTFLFSKLDENDLVIINIIIQDKLTEEKLENSKEKFSVNNTFISLNSETKHSTIEQNTYSANDDPFKTQRNEVGNTIIEKEKKYFEDLKILRNRFLEPLRDDDQYSSEKFIENIFHNIEEIINLNSRIVVRMDQELESQEEFSIIKIFSNFEQEFYKYIIYISNYESAKKSVKRTINNYVQFKEFLEKIESEADLSGRDLKSLLYLPVSRAASYLEDFFKLTKFLGENNPETKALESLVSKFQEIVDQIQQSKIKESQETEEIKKGGKLNAVISGFVMEKENKKNKKYIQYEIDVSTGYHEWKVFRRYSEFRQLHSVICKNFPNRPKLSFPSKTLRSSLSYDVVTQRKAKLNRYLSIILNDKNMRIFDKLFEFLEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPR2</accession>
    <name>A0A9Q0LPR2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytochrome-interacting ankyrin-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_00049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPR2"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="441"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5076732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="543" mass="62948" checksum="894881B314BD312D" modified="2023-09-13" version="1">MFEFDDKTELKNFILFDLDSNPNFIKKTNKKNQSLLHLAIFHKFPKNVIQKIIQYESNINRIDLDSETPLHYACKYKSSREIIKILVKNGSKINLPNSKNQYPLHIASKVSPRTDILSLLVNRDLDINAKDAFGMTSMHYCIQNKGDFEAIKFLQSTGGDINIQNKEGRTPLHMLCSSNTNLDLIKGVINLGADVTQVDNNGKNVLHILCSAKTSEAKIAMLIQKGAQINVVDNMGKLPLHEACRKILSVDILRLLVDENTDLNQIDNQKKSPLSYFLKGKSKMKQIKFLIWKGADIPVSINGKHSKSMIQWWKCYNSICEDFANLVKRQEFCDFQLEHSQGFIGAHESILRLRLNDPEDKVDRIPLVIKALKTYSKASAMRILNFIYSGHIYPQNWNKFFPELLEFVKEIGKDEKWIALKRGRCGLVRDLTRLFHEKDSKDFTIFCNDIPLRIHKLVLITRSETYRQMFLQVNDNSNQVNDYSGKSEKSLRAFFEFLYTDDISMNLEEKQLVELNEAQDYYQMNQNSSLKDVLIRRKQNWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ45</accession>
    <name>A0A9Q0LQ45_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ45"/>
    <dbReference type="OrthoDB" id="2439862at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="307"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="58764" checksum="741F4DF934BC1EB0" modified="2023-09-13" version="1">MDNNDNNNQIENANQNQNENEMKNLEKKVTKNLIKDYSNLLNGNSFTDFSIFVENGSNTFEFKVHKSILSSRSPFFNESLKGQNDIDKIFLNNFNKKEMESILKYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKYSISKQDFDKLKQFDIFLPKSFLINLERTIFQIQDKENQQKINEKEKKIKRREKKIKRRDKRIKSFESENDKKRKEILDLKLQNEKKDEEIHNLQLSFQKELENTKQEMEEKWKEEIEEIKQGFELMEFQKIFSDSEIITEIKYVKKLQEWINDSSFCYKMKKGFSAKKNGFDSKTWHNICDDKGKTLVIIKTKDNFIFGGFTQVGWTNDKSKWSKMNPHNSEGGWIQDPNAFIFSLRNDKGDRKEDLFPTQQGKQKYAIFYFYDYGPAFGCDFVVNSKLQSGNSNFGYNYNLPDGIKFKSKEANSYLAGSENSWIVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQU7</accession>
    <name>A0A9Q0LQU7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor h</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQU7"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF370">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="379"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="539"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="772" mass="91235" checksum="3367D85796003C75" modified="2023-09-13" version="1">MSQPKDSQLTPKLRKQQRKEQKEKEKKEKKAKKELERRRKEQQKREKKQQKANSKKFSTLKSQSTTTITKNLDLDSTSNQDKPKVFTKNSKENSKENSKENSKENLNENLNENLNQNKIENQFKIESQQPPTPPRELSKSHLNQEISNDKNNLENQNENQNENQNEIEIENQNEIEIENQNENQNKIQNENSQQKIKDSDSELSKSEIEDTPQETEDEDIGVPKTEWLAYFMRKNPDILRLKERARVLTQEETYGKLCEIAYTESKESLSSRVISQLLMNYFYQNKFYKTLKALESETKYPFEIHYNKSYLKPLVCVSIPTMDHLWDHQYPTPTDLDDELEDPEVFITEDFFSGIDSLHDVSVWDEPPDNETNILYSEDKNELKAATLNKLILKLVPETELEHDFRIIFLSTYQSFTTPYMLLYKLIQRYNVPRLPDLSFESYQTKKNCIKLQVCNIIRFWVKSHISDFDERLIQQLLEFINNELPKDSFVEFATNIRNLISKKLSPKELRQRDDLSKAPEPKVPKNIFSKTLSFLDIDPEEIARQITIIDWKLFSLIQDKEILTLSWLNPRHNHESSNILAFLHQNDKIRNWVCCLILSFENQRQRSKCITRLIKVSEHLLTLHNYSSLLAIFSGFLSASIARLQITWSEVNKRNKETLEHLLQLGSSASFYENYHNKLRESELPCVPSLKVHLEEIERINSQNPDLIGQMINFQKRCSFYRVISQLMKYKDKNYVLQPVYQIAVLFNQFPFETEEKLFEKSLKVEPKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSF2</accession>
    <name>A0A9Q0LSF2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box/lrr-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSF2"/>
    <dbReference type="OMA" id="NDARWQI"/>
    <dbReference type="OrthoDB" id="423607at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="774" mass="89164" checksum="7C637E95B629C1D0" modified="2023-09-13" version="1">MFPDELLIKIFQNLDIKNKIKAGLVCKKWRNCSKSKKLWKKIDLSPKGIEIEMLPIFRNFSKYPEQYKYDSNSIHKISKWANEVEEVIFKNCKNLNEFSIVNFISKYQKSIKSLNLSGMNGAITRWGYSKMTCLKNLEKVNFEMCFWVKDRTIKAFVENCPRLNTFILDYCDLISDDSIREISQGCGDKLIKLSLVGCKLISEQSLEYLTNCPNIEYLALGETDEFGDEETETESETETETESETDSDQNQNENENQNQNQNQNENENENDNENENENENQNQNQNQNENENENENENENQNENENENQNENENENQNENENENENENENENENENENENDINKVVDEIMNEFDLDENEKNIKKDNDENEKNIKKDNDENEDEDEDDESEDVSSIYDGYLQSIFADFSSECNKLKYLDLSDHKELNTSSLKALLGGLTNLKTLILDECDITDNILDYISINNTRLKKLSLESNENVTNQGIENIIQSCPFLEILDLNEITSLNDEFIGFLENENDNDNEYSQILNNIQILRFSSSEITDKTVELIVDHLAISNCFLNLKELDFEFCSLITDKTLEILSRETNNLRAISFSSCSITDEGMKKFAKKSPNLIAIDIDECSQLTNIGINEIAINCTKLVTLAISATNLNDQNLKTFSQNCPNINFLNISNCKQITDKGLKYLSKGCKQIQWIDCKGCDSISTKGVQYLTTNCLNLQFINLRDIHNLDGVFLGKLKEEFYEKKVSIKFWDENHDLSSISSSTKSSTKSTSTTQEDSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSF4</accession>
    <name>A0A9Q0LSF4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5079011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSF4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5079011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="82" mass="10033" checksum="90B854D04813363B" modified="2023-09-13" version="1">MVNDNFKLILTTNKEEENFGNKFLNQSKFNLIVKFRNINLIIPKFPFFHYFYEVITEDYHQENKDILKDIVDEPIENWSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSI4</accession>
    <name>A0A9Q0LSI4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorting nexin-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSI4"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="457" mass="53025" checksum="62727B8B85853455" modified="2023-09-13" version="1">MISAVVANHKISSQKYIEYEIIVRRGQQKWTIWARYSKIRKLNNLLDKQFPHLRLSFPPKKFFGNKDPKFLKERKKLLQNFFNQILFQPEVLESSLVKDFLQLENQQPTEENDSLFGNLEIDSTSVNSSYQENSNQNSNQNLNQNSNQNSNQNSNQNSNQNSNQNSNQNSNQNSNQNSIQNSNQNSIQNSNQNSNQNLNQNSNQNSNQNSNQNSIQNSNQNLFLEKNENIHSLRKKAKILLVFSEKPIEKDEIIGNIPKILVNNKFDSKKIDTLDNIQEIFKIEQSEINNFNQILINNLVGIDNQDKICEILYNFLSKPTEFGSLIVLSNMAVDPLLEFQNEFTHFIPVCFDENLEDQKEEKDQQDQSFVINNPHHLILNGIQIDDLQTIPRSFYKMKNTHSSSEVLVQWGDSIPTLILSQFKPNSFLIIINGLNFYHETALLMNLIDFSLISFFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSK2</accession>
    <name>A0A9Q0LSK2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thap domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_14626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000040">
        <property type="protein sequence ID" value="KAJ5079086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSK2"/>
    <dbReference type="OMA" id="NAHVFRI"/>
    <dbReference type="OrthoDB" id="2668416at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="161"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="325" mass="37617" checksum="FAA5E8601406CAAF" modified="2023-09-13" version="1">MQEIDEFYSQNEQNNQPDLIQEQSDSDDDQFEGYISYENLDEYSDDNRMKILTNFDLTELQQLFYLVAEAFQVQGRGARRTILSDETTLLMTLVWLKHYPSWNRLGSDFGISQTWARDLVTDTLQRIEPILVQDQIRWIGKAEQEAQGSSFAEFPNVLGIVDVTCQRCQRPKDRFEQKKYFSGKHKCHVIKSQTINSCSGLCMSFFTGVEGSIHDLRIFEISGESAMFQSYSIMADKGYIGIQHSTQAEIPFKKPRGGNLDLESEFYNATIARTRIVIEHYYARMKNFWGSMNQVWRGERVNLYSTTFGICAALTNYHIRNGNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSY3</accession>
    <name>A0A9Q0LSY3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSY3"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="116" mass="14101" checksum="DB1430773BA168D5" modified="2023-09-13" version="1">MKRIYLNENEKDFIIEKNEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQLLEYWIYSNQIKKEIEITKEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTP3</accession>
    <name>A0A9Q0LTP3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NAYITEY"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1354" mass="160872" checksum="4423EDAC595DC7CF" modified="2023-09-13" version="1">MLVGDNQYYSEALQKKVDAMKRICIGNLPKILIIHLKRFQYNYETFQRYKINKEFHFPMQVKMGKYTKEGLEKSDQMKKLESEQNENEDEPNKQNESNESMPIPKEVEQISSENDGEEYELVGIIVHNGSTESGHYYSLIKEPKTSKWIRFDDIRVLEFDMSDLAEECFGKGGIIVPNANDYYDSNEKRNSAYLLIYRKITQYPQNDLDSPQKSTQITQESIPQKFYQEIIQENLQFRAKKYLFNNDYFDFCFSILELGQQTYSNSLTSLTTNLTQFAMKFLINLIAHFKKQRKFKYSKVKDQDQDQEEEEEDWYSKCILKMGPINEFRLQIYSIIIEALKILATEEKTKISSFNLEEKKRNEAHLETLQENEVYEYWMSMQMMRQIKDEPKKQTEVSLVIEFASQLLQTLPEAKFHFSALSDYFGFLYDLLSVGEAVIEYFASTNLIAKMIDFYLDEKSPLRKTANNKQNQSQVVEDSYFQQQFVKMLSIIEEIVLKTENKINKSQEIDEKKSLVLSKIDYRMITEEKFIEKMISLEINPESLKKILNHISFENIEFTQHIIELLSREMKSKTYLEIGRYFTFYNSLLEINDSLSQQRLDLVLSKLKDSISQKFSFENSTSVSLNYLGELCKSNAAAMEWFLGNKDKWMIEWLVQNRYLAARNSVLQFIAIFFNYKESEKDQINTKILLEFEDYFINILPKIKEECYQGVEKEKEEMKNLNKSKISDDFFQMTSYFDFFRMYCLEQKEAAEKLFANFDMFWECMEYIDKVMLNYDLNKKHLLMLFEACFRIYPDQLNQQLINNKERTEKYLQLFDSFQEHNAYITEYLQSTLKLYFQILQQCLNQNEEFANLLKSSKLFKVSIMEILFKSQDFYSEIGDIILKTFGMFALKQKDYRLEQINMISSNVYEFLNNSPITTIKFLDQMIIDKEDAWMFYKTENNFYYLQLIITVFASQMHQQNSNFRSLRDIIMHIYQIRNSRFDNKGANQAILHGLSLVDKMTKLLGTDIRNIEDFVINQKMLSVLYQVVPFIGGIDEEVSNKYFEVSSTLILSNPMLVINFINQIISFHHANIESHRLEELRSEHTGTKSNLDDKVFFSINEYHHFLESIVFAGLKLNQKQVDDFQKRIEEMETESRKKYQSENENQNENENENQNENQNQNQNENQNENSQNEIESIRLRAIKLLFFILVDISRYELFNSRFLKFSNKLISLYPDDFKEAFGQYQDYLVLYFEKTIEKCIVVFNNEWIFFQEFIKFLNSKNDQNSNQILSNLLSKIFLGIENRKNDSSITRLEELKVLLISAKIILFETKNSQEMIKLFVGNVFGSDSLGWIFEQFQNNQEIIDLASFLISYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUC6</accession>
    <name>A0A9Q0LUC6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-5' RNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_04549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUC6"/>
    <dbReference type="OMA" id="RRWMPHI"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37474:SF1">
        <property type="entry name" value="2'-5' RNA LIGASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37474">
        <property type="entry name" value="RNA LIGASE/CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5078826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="22102" checksum="7496C8D14C319B99" modified="2023-09-13" version="1">MQKSFKSAVCIICEDESIQKIRKKHDKNFIRWMPHINLFFPWVPEEEFTKYNEKLQKAISEIEPFKIEFNKFGYFQHGNSCTMWLEPETENNNIIELQKKMVEAFPEFNELNTKSENGFTAHLTLGQWRNQNAVQRAIGSYKKDWKPLSFYIEHVNVISRGDKTPFKVKYQVKLGKGEKNMVVKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUE8</accession>
    <name>A0A9Q0LUE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G protein-coupled receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NECEASR"/>
    <dbReference type="OrthoDB" id="200667at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11319:SF35">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN PMPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1274"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1329"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1379"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1467"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="862"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1651" mass="187401" checksum="73B3C5603882D771" modified="2023-09-13" version="1">MGKFISLFLIYFFSILFLNYKIICDAYLPSTLSSLVSNENYYFESGTNYNFAVGAASNLINISISCNETLSKTTKVLGVLNFINCSNIVINASSCGSKLQFTPQSTIEQESDISFVSVVFLLTADIESFDSSVQLLDCDISQLDVSGNFIDGHDSHFFIKSLNTLNYTSFPNFYFDSEDNPNSSLTLDSCDGSFNLIVDAVQIALIDCAPLEMTIQNTNLSLNSSYIQINDLNLVNSYFEMINSSLKNLILSGNSSISGDTLNISESLSFVGDNSQLKVINASVYFNGTSFSSDETSVQIQKNFSIFSTTCTVQSTNLYLIVNNTNLQINYSISIKRIDFIGDTLLHGSAILQVSNQIFFNESGIKTIYSPLNILNLINSVTYSGNDNFIYLYNDFFIDTSLTSIQLPGIYSENNESILGLYSDTINTNYSIPFLEINGGNISGNNNFLIVEDNISFNGNSLIINNIQIDSQETNFIENGIIQFQNSYLYSKSSNFQQDSNFTIFGNGLFFSQELNDEGILIIDNIFGGKNIQIQENGDLKLSNINSSNFQNSNVVLNGSLTIENSIISDPFDSLISNSANQFPLIIINSQISFSNNQFDFPSLQMINSSLTSKSFVCNSEAEISLSNSTFNTQEFLNNGTFLIDSSIFSSSINGYNYGNFSVNNSDAFFQKLESYGDFQFNNSNLTLNDNSFLNNTNNIFGISYFINSIIEIIDEKLLSFNGNYMIEDGGSILGEFKIEENSNITLLLEENNNTYLSINHQPQIQGKLYLNLLRYSEDQPRYYPYKAIYLLNSFNFSSEQLESSDEQFIEINQNENWIIAQVKGCKKGKYSNDFDQECKDCSEGEYNNETGATSCKKCPSGYISNQKGKEECEPCNEGYYQPNTGQSFCFECQPGTHAPHNGSDHCQECPGGEYNYNNASTTCDVCGAGNYSDNPTKCDFCPLGKYNPKEGSTLCYNCSIGTYSNQKGKTFCKACDVDTYQDEIGKESCKVCPENSETNGYGATSINDCVCSLGYYGIASKLCEVCPEGSLCNDIGIVIPYAKEGYWHSKTDPTNYLECAVKEACPGGGTDICNKNIGYSGNLCAVCLKGFYKFGSQCMKCPNNQKNRLILVGLFIILLCLFLFIIARKIRNYFASFSIMFSFFQVLAVISGLKLNWPGSIETTWRSISLFNFNIDYLAVECSLQLSYTQKWILCMLFPFIILAVLLIVYLIAFLHSKLIEKCGAGFMRKFPRFCSKPTRKTTNKYIYPFSWIKFKISQIFTHGFSKQKRKTLYNNLINSYTTILSFIYLFISFKALQIFDCKKQTSGVYTFEGDPSLFCYEKWWKDLLPWAIVCLIVYVIGIPVIFIILFFVSSKKLDEKTFDLRFGLLCSRYTKRWFFWEIFIMIRKLFLIISQLFISFDSIFQSVICVIVLLCALVFQVNSKPFVSDRHNKLEFVLICFSEIILFSGMIFASNDLERTSGRRILATTIIAIIWISFSILIIMILYEIRHRVRVKKGKEIDEIKKSDSISSGQSILKFLDSKPSFLLLWNWILESSEHKNKLQKEFFQQIKDFYNSNQVYQQKLNIDEFWESFLTKWKDSFYPIIQLWFLQASIQEKIQFMRILSKIHFESFLYLKSNSTKKERRKTKRLSIQYFKQNLLFIPQTNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUG0</accession>
    <name>A0A9Q0LUG0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Wd40 repeat family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_14749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000047">
        <property type="protein sequence ID" value="KAJ5078724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUG0"/>
    <dbReference type="OrthoDB" id="1651911at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="6">
        <location>
            <begin position="195"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="279"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5078724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="383" mass="44392" checksum="6C071505B17838FC" modified="2023-09-13" version="1">MNEEEERNIDLEYKIWKLYTPLLYEFVIVYSLNSPAYSITNLYQNENSENYLGFLKDSLFLINTSIPKDDDIINIDYQDESEFGGFGISQNTKVETKHLLSVSENANILSLNSNKEGTKVLLSTSQGPYFFNGNFEQPIFSSIEIEHQPIVARHHFSMNEYNDKKFYIWNTMSQIVECIDLNTLKSESKINAKSKIMDFDWNSKNENIFGIVDEDKKIQILDQRTDSNTINSSNIAHDDSINCIKFHPELSNLFATASNDKSIKIWDLRNFQKEPLFKLQSHNGSVRCVKWNPLFGDIIGSCGLDRKIMIWDLANSGKKLKPESQDGPPELLFIHGGHTTTISDFTWNYKNPWVVASTSFDNILEIWEMNHNIYLDFDEFFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUX9</accession>
    <name>A0A9Q0LUX9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000029">
        <property type="protein sequence ID" value="KAJ5079518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUX9"/>
    <dbReference type="OrthoDB" id="2306559at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF42">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040209261" evidence="1">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="148" mass="16815" checksum="B5E4EADB41640BA2" modified="2023-09-13" version="1">MISVLLELLLGRLRYFIAVVPPQPNSPPDLSSESSSKGSSFPAIRTKPVPFAVGSLEDDEAFGYLKRVIVTPAVYPRFFEFLHFNFQSTGQNSHYSQSFSRSYGSILPTSLTYFILLSQRLLTLETCCGYWYVLFRILNITNFLNIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVA9</accession>
    <name>A0A9Q0LVA9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sesquipedalian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVA9"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="744"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="882" mass="102560" checksum="7AD97BA79CAD5E6B" modified="2023-09-13" version="1">MKRCLLDKPELLNQFKYLFNHPQPQKLIETKVDSKTIPHITLTEALLETICNYFNFHPRFYPGVGILKGLTAKFNDMNKLMIEEIEITLTALNSDPREMIHLDDIDDQIDKIPLDNANISTQDSFNDNQNTSNFFSELNLTIFENILIEISKLKLVFLDANSEKNCSFLMKKAIISIGSSESMKKSMFTDEQIKEKIKSKQITSSDMVLVKIESPILSVKLAKNILDRRVANSGFSKITFETIKIEFSRFIDKNNKKFISRLLSINTLSIHDNEIGNTIFIYSLLIGDLIGKYKQQEKLNQIPSEFFIQINYMFIILDQLDKNICQVTDLNLSQSPTSNLVLKFDNILISQYNEPQFQTELQIQNIQIGFGDLMWRSNEIQKNDPRVLAFLKSVNTNSKTKFFTMKTLQKDEKQIDIDLHITKISFYGNFSEVYYVFQFLLQQEKNISTYINNLYQFEKTILIKKTSQLSQIQFYIRKALYSEKLNVGISPITKLKLRDPKKESEQSGIILYATIEMLQITGDSLDLFKQNCILKNLNASYRDQEEKSEKSSTKNLLSVSTNAELIWNKEYNEMLQKDIRGNLTVKTPEVELKFPEGVFELFKFLGPDIGSFLLKRRIPKPKGRSSLPFEIEPTQEEINSPKDEKSKSLDELGDNDNDNGIEKNILPNTISKSPRVRVSELFSVQKKENESGIQSVLKWEIFDLKEKIARSKLQIKQFVREVNNLRSSFDHQYHTSEQKISTKQVSKAGFLTKRGHKVKSWHSRWFILSHEKLRYFKNQQPKDEEKHTELPLGIINLRESEVSIPEQNIIFKRKCFEKEAKFKKAINFQSELFPVPTKNLKSHQENLVALIQNNYELIRERISTLSQSYHFLLSQLGEHGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVH2</accession>
    <name>A0A9Q0LVH2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVH2"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="303" mass="35347" checksum="6B123FC8CE05C38B" modified="2023-09-13" version="1">MNLEKNKENKNENKSEIDIVFISDTHQFHEELILPNKIDILIHSGDFTYKRKKKKNQVKIFNNWLGKLDKEKKIEHKIIIMGNHENWFKYRRMKTKLKWLSNGIYLQNQTYNAYGLTIFGSSHKPRKKYSKLIPNSAQIIAIHAPPKGILDMQYNDKSRGNKTIYDCICDLNKSKKMQRINAFGHNHEGYGIQFSEEANCFFVNSTTNGLPSNIPIWFKAIRENDHFKFFLIQSGCRIDFIERIGRTHKFKRIQNSNLILNQNSNLNQNSNQNLNQNSNSNSNSNQNSNQNSNSNSNSNSNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVS1</accession>
    <name>A0A9Q0LVS1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVS1"/>
    <dbReference type="OMA" id="ISSMWND"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="159" mass="19755" checksum="9CABED1C0382C7B1" modified="2023-09-13" version="1">MLFDKKQKNGLTKIKKKETEKEKEKKRKKKKDKIEKDKKTRQRSKKEKEEKEEKDKNKDKKEKKEKKDKDKKDKETDKKEKKDKKDKDKKDKKDKKDKDKDKEKDKDKEKDKDKETDKKDKDKKEKKEKKDKKDKNKDKKEKKDKKDKKDKKEKKDKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX23</accession>
    <name>A0A9Q0LX23_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000008">
        <property type="protein sequence ID" value="KAJ5080567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX23"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21067" checksum="E771DF074588E917" modified="2023-09-13" version="1">MASNISPILNSSIFQNYQLFWSFFILLLLFQAKHKKAIIQFIVNIPFNLPFLPEYIQFYIFYLIHALNSKEQDFVLKSSFSSIIGKLAGTGRQFIYNSREEFPNIKGKNYNLKNFKVSFQISHSNSLNFTSNSFQNISFDISQCIDITLNILSSNSKSQNKNIHLNFLEIYFLVSSNIFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXD5</accession>
    <name>A0A9Q0LXD5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A-type inclusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000007">
        <property type="protein sequence ID" value="KAJ5080587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXD5"/>
    <dbReference type="OrthoDB" id="1914786at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="673" mass="81408" checksum="D5B8E7817069E376" modified="2023-09-13" version="1">MYLENGYQSPEIEYQSEENQNQNNQNNQNNQNNQNNQNQNNQNNQNNQNQFIPIKIGPVLKFTSVITQIDTQKKEQKYFKSKILKIINSDKLEDYINFRDISLSMMDPKIKKPTGWWEEIHDKAFLFGVFKHGLGNYDDIHIDPDLIFNEYLSHRKYKSSKKKYERLHKKQIESEKLRNERENFQTKVEAQLKELNQKKQMELEQNLNLNENQNENQNENKLENKLENQNQLENKNENQLENENENQLENENENQLENKNKNQLENQNENQLENKNKLENENQLENENQLENENQLENQNQLENENENQLENENQNGNENQNIDENEKKQLEQKIERIKEKIQHQKEKLKKREERIKKLETKLSFQPWPKDKILDEYFEELIKSYKLKQQKIANEEKKKRREEKKRKKKEKKRKEKEKEKANRSQKIQQFMDQMKSKSKSGQLNRQQIGNLFQTQFKNQKLNPEEIKKLIGLYNQLQSQNTVKEFSEENRKKIKDTLVRFGIPINALGIPDWVQFYKLTNIKDTEMEQHLAATISRRIQLNSAIARYYLFTNLGVLLKGIKHWGGGPSWWKKGVYDHKLFRGILIHGFGHFDRICFDRSLPFFDEVQKVWMKKQKERFEFHQKFHQGETFQKKVFNLQEVSSYIPTDTQWLTRINFVIKFLQKKIRFNDYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXY7</accession>
    <name>A0A9Q0LXY7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000005">
        <property type="protein sequence ID" value="KAJ5080659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXY7"/>
    <dbReference type="OMA" id="NDDHTFF"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="496" mass="59942" checksum="0ED8FB21B1D49349" modified="2023-09-13" version="1">MENNSKQKPIKKFTCYSCNTEFEIRELLIEHYKTDWHQYNLLRRSSEKQIVTFEEYQQIAKNLQDLISKRKNKKKKFFLKKKSINTEKAERYKFFQEQRRFFKKANMIEDNSQLSDDEIILENEIKEMKVNLEENQNQNQIENQNQNQNQIENQNQNQNQNQNQNQNQNQIENQIENQNQNQIENQNQNQIENQIENQNQNQNQNQIEENEKFQDVLTHCLFCSAKFDSINKALNHMSSIHSLFIPDHEYILDLHSLLHYFYDKIVIGNYCLFCNKKFNNIQAVRAHMRDVGHSKINMDESNWEEYCEFYDYTSSYPKENQIENQNQNQNQIENQIQNQNQIQNQNQNQNQNQNQNQIQNQIQNQIQNQIQNQNQIEENKEIDDKIKKYIKYSKLNQAHVSETTNELVINGKKLGHRDFNYIYKQKIQYYPTEEIHQNLTKQYKSLGWIGPEYSWKEIIKLKNQDSKEFKKRNKQILLTSIQSNPKINFTGYGTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXZ3</accession>
    <name>A0A9Q0LXZ3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">32 kDa heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000021">
        <property type="protein sequence ID" value="KAJ5079920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1338"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1589"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1689"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1752"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1791"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2002"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1426"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1966"/>
            <end position="2001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2021" mass="231518" checksum="70A3EBE7649D879C" modified="2023-09-13" version="1">MKKFCSNLFKKIFKWIGKPRFIDFVGDDVIWRSLTIFMLSTFFIFTFGVAIRYLLEGTEINEDKIGLNLGFYQFPNETEVYYHQPFNAKLRVSKKFKSDGITNCKVIVNATTLDIPENEEGTDLTLLQMRDKLKTGIELSGDTTQYTNNDGIATFSQISVLSGSSETVRLTFFSQCEFKSELNNSGPSATLFNNINSEISQISFPLSLKTQINNLWLQNNDSIHNQLVNYGDVILLRYSFGIGSENYTDLSNVRVSLVSGFRSWDIPEYESYCWIEIVSINEDLNLESNINYTFLGSTKTKMRFTAFAEGIQVSTYDEIIYVEIPGYFILSFQTNVSMVLIQQNGSLSVKEGEKFAEPWIISVKDATANGIANKPVVAKISKQCNYSVSENQEPIPNSKYLLNTIVMTDENGIANFSNLKFSVEGLTKNDCFFKIKFVCDDFVVETNDIQVVPSVKEIIWIEKIQEIKISSDFQLESDKWSIIQVQDETRKGIADKLITFICDNFTFDPHQFTTDENGFAFLCLDWACVGPSVNGSNQTCFVDVDDIQSDPINVTIYFFEDFDPRVVSRINISNWDENIESGVELHWNLLIQDFNGITMDNETFNLTIFVDPCDLPMGFAISPQQGYWEVTNGTATISTTIYGIAMRSKVCFSVSQGYIPDMTYWNWMECFEINLLNAIEKVEIIYSPDSDNYLLPGVSFGNESIKVKLFPENIHQSYSNMTVHVLGFNTNDYYGTIFGKNSSFITKNLTQNLYQGKENITEQDELILENFVINKQSKNEDGDYIPFDLMVFINGVPANSKVMVSICSPSQLITLTVTWNTTLPFISGYQKMTYQPKLQINDSTTGDPIQGLYGYIQIDENGGNDNNQTYPIDFNSEQYDNFVQSIAPSDENGEVTWDLSLLYAKKDGYASLDFLVQNCGFGSDYERVFFNISKQNVKLEIFDLPYQILLDQKFPKSPKVLISEKSTNIPLENKYVTFWVYNQSSEEWEGMGFEKTNENGIATFSSVVAIGKQEWETIRIKFECDGEKYEESIKIIRDPTHLFVLSSPASGCQVGFPFPFSDQVMVNKKAYMGSSIVQLFSFSYPVPGKIITAAIVSQNSINARLDPKNSIATTDENGIAVFNLRMDSGTNENYTIQFIYNDIHTSSDSFYVENPVISVKADLQNIPSELNIGEKFSAVITVDFTLEIHKNISFPIEIITECSNASASGDDLFTDIGGIRNLQNIRFDSSSNIPSCLDEEGKVKAQIAFSVLGIQSDFQTVLISSPDKFVFTKALDSLKQSVIFWVVSFSLVLPFFLNSPKNHNILTFVIVVGLMAVLIAFLPKLIANPERSESRQFVALSVFEAIISSLALLILLLIILARIIPKFKIWIEKHFFAHERMSGYWNLLKKILPIGAKKSLKFLEIERKLVKKFSDSESSDLENLDLDDFIENQNENENQNENQNQNENENENQNQEIELESVSENENEKEKKALEKKQFKENLKNKKISELSEKEINFILKKSTNNFETQRIVNSLLFKRELEPKSEEDDENEKDEEKNKKRNKCSIFWSWIWKWIKEMMKKIKSKFSNKKNEHREYEEYYDFYYPQRLLAAFWLWVVLVALIVLLVTKIIKNACLTLQLMRQEVIGDIQESNCFTGKPLVSLYSESISIYAIQLIQQIDEMCSVDKNPLENSFSRFVHSFSRERANQILNAFSVISGVSALAAFVILLLLWKSIFNLYRKRIMMLRQGKKPFPGFSKVDPIEVTSYTNLQVWVGVIAFCVVWVIAFIILFIIPAIYWFASKNLLYNILKYVAIFIAITIAYQIIFVVIVQKLMTKICIRDNKVVERTVFSVYDFVKFFMSIFSSATEAVKKFVGTSSGSISSILRLDDKKSFDESYAAMMLIDHETNNPILRVFANCLMDFLSHQRKMIQSILPQKSNVSDKEFSMAISFLENHPITDEPFQKEKMRKKFLFLLSLSANQNLKDFRNKSIKIERKKEKLLKLKEEKVKKMIELANKFQKQSTDQLKQKLKGKSKENKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LY19</accession>
    <name>A0A9Q0LY19_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000020">
        <property type="protein sequence ID" value="KAJ5079950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LY19"/>
    <dbReference type="OMA" id="QWRGCWT"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="112"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="202"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="241"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="420"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="463"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="466"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="599"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="642"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="645"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="685"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="846" mass="97991" checksum="0AB30A495DE98FA3" modified="2023-09-13" version="1">MQKKIQNSLQSFITSSTQIVTIEEVINWMKQFPENEKLQENFCIALKKLEEGNGVELSKAKGIKIAKLNGIEPIIKAMNNFSNNESIQEDSISILKDVVIDSQNQIKIRELNGIEPIIKAMNNFPTNEDIQWRGCWALMNIGINSENEIKIRELNGIEPIIKAMNNFQTNEDIQWKGCWALMNISVNKENKIKISELHGIETIIKSMNNFPKNENIQWRGCWTLWHISFNEKNKIKIRELNGIEPIIKAMNNFPNNENIQLRGCLALNNISINSENKIKIRELNGIEPIIKAMNNFPKNENIQLKGCFALMNISVNSENEIKIRELNGIESIIKAMNNFPNNKDIQWRGCWALMNISVNKGNKKSKKENKIKISELHGIETIIKSMNNFPKNEDIQWKGCWALWHISFNEKNKIKIRELNGIESIIKAMNNFPNNENIQLRGCLALNNISINSENKIKIRELNGIESIIKAMNNFPKNEDIQWKGCWALMNISVNSENEIKIRELNGIEPIINAMNNFQTNEDIQLRGCWALMNISVNKGNKKSKKENKIKISELHGIETIIKSMNNFPKNENIQWRGCWTLWHISFNEKNKIKISELNGIEPIIKAMNNFPKNKDIQLRGCLALNNISINSENKIKIRELNGIEPIINAMNNFPKNENIQWKGCWALMNISVNKENEIKIRELNGIEPIIKAMNNFPNNEDIQWRGCWALVNISVNKENKIKIRELNGIETIIKSMNNFPKNEDIQWRGCWTLWHISFNEKNKIKIRELNGIESIIKAMNNFEKNENIQLRGLYALSNISLDNKENIKEIQRLNGINLIIQTLKNFPNQEKIQEIGNKILQHLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R479</accession>
    <name>A0A9Q0R479_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Activated RNA polymerase ii transcriptional coactivator p15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_13489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000140">
        <property type="protein sequence ID" value="KAJ5066552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R479"/>
    <dbReference type="OMA" id="ERIYAQP"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5066552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="220" mass="26883" checksum="EFE8D939DE7386D2" modified="2023-09-13" version="1">MNQFFESFFSQKIQTLYKENSNFDETQLFRLMEKDLGFKNGDLENCFGDFKAYFKENKHLIEKENEKENQNEKENQKENEKENQKENQKENQKENQNEKENQKEKENQNQNENQNENQNEKENQKENENQKEKENQNQNENQNENQNQNQNQPKPLFELDSTMPIYVNQYQGSTYLDLRKYYSVDNQLRPTKKGITLNKNQWEKLKKFKKKIQKKIDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4L9</accession>
    <name>A0A9Q0R4L9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000132">
        <property type="protein sequence ID" value="KAJ5067197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4L9"/>
    <dbReference type="OrthoDB" id="10001977at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="293"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="482" mass="57515" checksum="A30E1E6F0EC84062" modified="2023-09-13" version="1">MENYLNLEKLSNDLKNLFQNQNQNQEESYFDFEINCEQNQISFKTHKSILSSRSEYFKTLFKSKMKEYQENKLILKDVSSSILFSILNYFYSGKIEINSENVIEILIFSSKYLIDELIEISSNFIKKNLQIETIIDVLKLSESMNLNHLLDFSYQFIFENFTKFIKTSFFLELEENHLNLILSNDILLTNEFELFQSIIKWGKHKLNINQEKENEEEEQLQKQISNIIEKIRFIDFSKEELEDTLKQDLIPNQISQKLIQFQKLQEDEKELDKFIQNENLFIFKSRFKFKSIIIEEIKHFKKLKEWINDNEFFYKMKKGFSAKKDGFDSQKWHSICDNKGKTLIIIKTKDNFIFGGFTQIGFTNDKSKWKENDRRYNNGFIPDKNAFIFSLRNDKNNRKPEKFTIKKGKEEHSIYYNYSRKGPSFGAGHDFSLDSDLKSGYSSFGYSYNIPNEIELFSNETKNYLAGSYSSWKVEELETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4M4</accession>
    <name>A0A9Q0R4M4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4M4"/>
    <dbReference type="OrthoDB" id="2369013at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="302"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="490" mass="58186" checksum="C095AD4FD08A506B" modified="2023-09-13" version="1">METYLNLEKLSNDLKNLFQNQNQKENQNESYFDFEIICEQNQTSFKTHKSILSSRSQYFKSLFKSKMKEYQENKMILKDVSSSVLFSILNYFYSGKIEINLENAIQILIFSSKYLIDELIEICLNFIKNNLQFETIVDILKLSESMNLNQLLDFSYQFIFENFKEFIKTSFFLELEENHLNSILSNDEILINEFELFQSIIKWGKHKLNINQEKENQKLEKEEKEKIQDQISNIIDKIRFIDFSKQELKDTLKEDLIPNQISQKLIHFQKLQNENDNKELNEFIEKENSLIFNSNFQFKSNIISEKKHVKKLKKWINDDEFFSKMKLGFSATRDGFKAKKWHSICDNKGKTLVIIKTKDNFIFGGFTQVGFTTNKSKWSRKDRKHKDGYIRDINAFIFSLRNDKHNRKPEKFTIKKVQAENAIWYDLNCGPIFGSGNDFFLQNNLHFGYSNFGHSYKLPNGIKEGTNEAKSYLAGSYDKWKVDELETFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4Z7</accession>
    <name>A0A9Q0R4Z7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4Z7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="164" mass="19680" checksum="DC5FB19045984885" modified="2023-09-13" version="1">MKIVKRKIINLITGLLKWFWVVICNILSQLKPTNYENNSFSHFEQENKKQTEKKEKAKNFKTKTKAKTKTKAKTKTNFENFENFADQEDLSFENKGLEHFKKVRNEWTYHQNKENLNEKEKNEEENLSLLRKEIKKENPFSKRVSLSSVVSVLEKMWDQKSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5D4</accession>
    <name>A0A9Q0R5D4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5067977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5D4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="118" mass="13788" checksum="017B0B6B192B4EFA" modified="2023-09-13" version="1">MFKTGNTIMMSTISQKSKSLHFPTFSENQAQIYHPGFYTFTSKMDFAEDKTRHVYPLLLMILNCLGYHLQCYSSSYELRSYPSFITVSFLFKNQTQPSRLFIRSVLSNCQHFPKRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5X5</accession>
    <name>A0A9Q0R5X5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C/D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5X5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040478091" description="Phospholipase C/D domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase C/D" evidence="2">
        <location>
            <begin position="52"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="289" mass="33757" checksum="CE37269BD3EE5737" modified="2023-09-13" version="1">MFRLISFFLIFSTVFSWAEFTHLSYGCEIINLYDFTSFSSSDNWTACSSTVQHKSFLLGAISPDFFTHFGYLDPSFHCLDYGIFLWNYSQLSYKSNDPNFDAYWFSLGFLSHLAEDEIAHYPFSWLYFSDDRELELAADTNEFLLYKSNPMKRPDIPEGFYDFILKSTNAYVSEIGWWNGFIPPNNSSLQYTVKKMGEFLDAEELLIIANELIYKEEMKEFDYCKRATQDEALADYNLAKNWSENTFIVLFQILQNPPQNCQGSIRKCVQFEFLKDVDVLFQNHGGSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R641</accession>
    <name>A0A9Q0R641_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">mRNA decay activator protein zfp36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_03046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R641"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000002">
        <property type="entry name" value="Zinc finger protein 36, C3H1 type-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="229" mass="26023" checksum="2CC4498F7A7E90FC" modified="2023-09-13" version="1">MTTSTHLNFGNNPEISSYLQQMIFPTTPLNNNLSDLKNNTRRNMPPTKQVSHSHSNSNSAIVNALSQMKDTGRSHKVTNPQVSLALTEPVAIPVNMAVTLPVQQVSSRFGTVNFPVVPNNVSPQNPQKERYKTEMCRSWEETGTCRYGSKCQFAHGYHELRPILRHPRYKTQVCKSFHENGFCPYGKRCRFIHSFIGSLPFSSQQPQFQEIKDDSIKRLPVFEKLAQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6D5</accession>
    <name>A0A9Q0R6D5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5068982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19599at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1629" mass="196163" checksum="998DA1F8C0365FEA" modified="2023-09-13" version="1">MLDLFESDKSINEIKKSIQNLKIKEEIIQNFYKMKQTQIFQKIYWNEYQQSLINEKKKISFEDLQNKIKQIQDDLIKKTKLISNQKMKIKQFENLFLKIIENEKTKELLEKENENEKKKELLENEIKLLFEISNIPKDKKIKQICSPILKYQEDRKNYSKIPYWFILVVPLFKYENEFYSNFFNPNLKNEKEMKDLSKISQIFQEIYKFIGSTLNKKYNFELLHQSIQILQKLKNDKEFKEIFDKINNNNLKQTKKYLQNLREEFKEYLYNEKLFKSFNDIFEIIIKIYQKINPSQKKLEKIFKKIEELILLQKEKETEEERNFTKQLDDLFSEFINNNNNNNNIQFILSIFSKEQIFSIIKEFHFENKNNNSLSLLKSFKPNLKNEEFKNFKIQISQIKIDSNFFKTFINKLEKLIPIKNSIKQRIIKIDENILKKSNSQFNQIFDNQNQNQNQKFFFYKLEKEKEIYEIVTSLYLGYCNHFPLKENVLFCDSNSTKNDINNFFNIYQIYNEKYENIPKNKYLFSIIHSHKLSQECLKVLTEKIQNISFTIHFPLLIFFYEEKIGSFRIVNQFPKCLITNKIKILSKKKITQIYKKYHKLYPKIQLFTSKISGMGKTYQIHKKYNEKYQKENYLYFNIILSKEISNDFIKDKQKEKKFFHIELPFSPNLETLDFIWGFTMWNLFENKREKSSNFIFDFNQEDLNNCFLAFEIPSNRKENSENGLNNFQSLKYFQEKECQVNYDEFSFIKFKLNPNFIIEKIEDKKLKNVAKLIELSNNNFKQFKNLQIEKRKEFINQEPDKKEFFNLIEKKILQKLPGQPLTFRIIFIICSILKSQIILLQNCQFLDSNKLLLLGLLKEENEEIYEKFISHLFSFYLDSIVNISSRYLKWSTKIEKLETNEFEDFSNLLKDRIDWNQKFFTFPIFLNQLKNEEQLEMIIISNNQIKSLFNQKLEKFLNNNVLIKIYENFQNDEEKIEIEKEMILKILNSFNSKQDIKDYPKFITSNNLMKLINIHYRLIAKLPVIFIEGNDYEKNLLIHYLLEEILKQKLIILNINSKTNKKDIEQIIEKAENIIKEKPNSKINILFNDFNTGSKECIILLKKILIDRSFDLLNLPYEINLLASIKSFQSKKYSSQIKPNESNESNIIEEIISKPQLIPDSFFEDIYDFGNLSEKGENNYIFSMIYQKFPKNLINIDKEKIIQIILETINFSRNYIQQQNKTNYSIQSLQDVFIFLNIFQWLIEKEICKKLNYPSNTNRIIFRESMLLSLFVVYGSYFIGEEKDKFLLKVEENFKKIKITISKKSFQSIFNSFSSSKNENQILKQWKLPQIKRFKIQCSQIFTQEYLQNQFQNIKKQKQQQNIPIIILKNFTNLSKENLIMIHSKIKKIMNKMIYNSNSNSKFTLILLTNINTNFEISGLTSRNLLLNLNRNQLEIVTKEIIKSFSKKIRRNYPNIFVELFSKIYQNQNEIISKQFKTILQENQPPLNFYGIKDYQYFLNNIGFYYGNEQKKKGILDICYESLFRNFGIKSKILNQILKNSKIEGFEKLPKFNPFQSIKENIQKLTKENEIQKYSDFIKTSRHLMIFIPNISIFSIILQYFSRNSIILFDSNSLIKSESQIEKEKSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6K0</accession>
    <name>A0A9Q0R6K0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6K0"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="179"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="466"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="566" mass="66221" checksum="3BCC709F47D88C24" modified="2023-09-13" version="1">MNEIIFFGLNSFPKLIKNKSYEITKPIQFKFENENENENENENEKQIKQISTRIFATIFLFENGKAIEYLNENDSYQNPSKIQIENIQKVTVNEFINISSLIKDTNDRVIQDVVSGYNSIYLLTSNQNVYGFGDNLFGQLGFDSETLKETKKPILMMKNVSKIFSGISSYHVFLLNSNQELFGCGFNGDGQLGLGESRKEETKIKELTKIQNIPKGKIIDIQCGSAYSIMLIEIEHQNQNPKRKLYSCGDYRYNGLGKYREDTYEFTEIKSSLFENDDNILDFSVGNVHTLILTSNSKLIGFGHNLFGQLGTGDTEWHLIPIQIKLPKLRFNENISNYHISCGTNKSFLYYSPPFSNLEEDLIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETIKRIYLNENENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIEEIQIGIDYFQLNQTNPNLFDLLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7W1</accession>
    <name>A0A9Q0R7W1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7W1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="317" mass="37996" checksum="30EE56CDFD99839A" modified="2023-09-13" version="1">MEKEKITNYSKKLNQNENENENEMKIEKIENDSFFEVDQELSDQNESLFDLIFKFFLKIIQSKNHIKYQNIIIKILSIFSTISLEAYKYPFIFLSKFTNKIIFEVLLNHNVYKIKLLTLQILNNLIKSSYIFRQIKRITIESKKRKNKSQKILDFIIEFIGKSFEIRRESVKLFTFISLHYYKKASSFFQPNLLISKLIYLLDKQILQNISFNEIKNCNITLIFFQEIIDLLSIMVIVDIENFSKSLLIMKHHFLSAINRILSFKKSFFYLEEKENEKLKTNLNLETEIEIETNYNGIKIIEQIIQKTEFITNLIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7Y4</accession>
    <name>A0A9Q0R7Y4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5070031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7Y4"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="745" mass="86604" checksum="321EDEB37418A7BB" modified="2023-09-13" version="1">MARLNVKSFIENELLALVQEEELKYVLSFIRKNIHMPGFFRQNASGILRSELKLSEWTGALTILISKFKEFKWNEITSLRSIFTRKRFRIFLKEDFMTLVLTNLIGLRWQMKLKQILRTLHHSGINFPSFVNHSSAIQYRKQKVHSLFMPFCPDNLYDYQNVDNYGQTRFSTNQTQGPDSFQKLLCHLNGELSFLRAVFPERSLAFFRTDIKDYFPRIQHNTLLYILKKIGVTDDWIEFFRKFLEVVVHIEGETYVCQRGIPLDHSLSILFSDLMLWLMDVSVFKKTDVELIRALDDIFFITVDTERATRAFKEIENFCSKMGFELNYDKTGYSFSDGSKIEELENKTKEIKWGLLKLKDCDWIISDESLKEVLDGFKDAISFDSPVLTIISLWNSYIHYIIKNLGIFVYLGKEHLNNVSKKIKEIEKEIFGEKGIVKLIKEKILERFGEGNIKDIPLGFIFLPLECGGLGLFQPNIYIYTFKQSSDYRVEKPTTLKQSTEDLGFGLSPFTQYGTTSLLQQQNQMFSNQYGGGFAAKKSAFGFGPRYTSSSMKSTSMKAVPKMMAKRKVFGRAKSKSKPIFAKIESESDEYEDEYDDNEKDIKDKKGGKEEKEEEELKVPGIPDFFNCPEMLLNQEYGYFYNQLQQPLDQSGPSHHNVDLSSQYSYGYGYGYGGGGGRFGYRSKMMARRRARPRTTTASYTTPYHIWLFHIYDDLKDFAGKLDYQHPDLIPSILIKQIKSNQRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R802</accession>
    <name>A0A9Q0R802_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein fam91a1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_11295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R802"/>
    <dbReference type="OMA" id="CRSKIMW"/>
    <dbReference type="OrthoDB" id="275996at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039199">
        <property type="entry name" value="FAM91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028097">
        <property type="entry name" value="FAM91_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028091">
        <property type="entry name" value="FAM91_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28441:SF2">
        <property type="entry name" value="PROTEIN FAM91A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14648">
        <property type="entry name" value="FAM91_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14647">
        <property type="entry name" value="FAM91_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM91 N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="FAM91 C-terminal" evidence="4">
        <location>
            <begin position="375"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="327"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5070091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="806" mass="94703" checksum="6601F7D4900C5231" modified="2023-09-13" version="1">MTEAELIQEIEPFARSKLRWEQLPILTQKKIKSNQNYISLVKKYSFQNQLKWKDNLISSFLSNEMSYHKQLITYSREKLMMYPYHIKEDIIRLLRITPFQYYKEMIIDVVSSEKPFDSIPNFSAADCVRLVGIGRNQFMEIVNKSKNRSGWKMKKKSTYIKKLLPEEPIRPSSDIEPWWLVGASPLFKDEYKSLPINSSKIIDELIKTNLQPAGNFDFDSIHFLYSKGFIYTKVPVESTDYITIPPLKNFVMNRTSDDYFEKLLYQIFVTHDERLSIQQIASLLNLELNSVINAVSVYCRLKIAIKKISTKDIEKTKKWDSSWNSKIQEIKSEIINEKEEKNNLDLNKENLNNQIEEEKQKANEKEEEENKFSLKKRIGFIFDSALPAVLMSSLDQGLIEQGVTLFEVGKITEEQIEKFITELNKINFKIDNPKRTKDSETLYCLKKTIKKLRNYCKLNQNENENLNLNENEKNQINIEGLDMVRCESITSLNPETQFKVLNRNYGVLASMILPTSQPIYSISLSKPYHFGPPIPEVNSPWFKLFIYDLIKSGPPSYLFTKGSRIRHLPKSLRPFHKFLTFQFGKDSFTFNEGNILPYLNESLLNSPVLVQGLEYFEGEYQELNIGFPFITKKEEEENKRKEIKENEYNQENIQFHPLIKKINEKLHLDNSIGFIKLMKICKPKKELNNNNNNNEESCEWILFDIKFGIPLIDYNLNNQIRKKIKENELFSEYNVKLHLNNMRKLSLKLLKFISNYCNTQSPFVFSQSNQQNLDFYNENSIFGKNIPFPNSNIFFENGKSSSFLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9C8</accession>
    <name>A0A9Q0R9C8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9C8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="313"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="479"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="584" mass="68122" checksum="39A9D878AF4DA585" modified="2023-09-13" version="1">MNDCLFFGLNEDPKLIENEEEEITKPIQFKFENENKKQIKQISSGSFSTIFLFKNGKAIEYLSEEYSNKNPSKIQIENIQKVTVGDQNEAILTIEGNVFAKGKDIYIKNPNEFINISSLIEDTNDRIIEDVVSGESSIYLLTSNQNAYGIGSNEYGQLGFDSKTLEETEKPILMMKNVSKIFSENTSNHVFLLNPNQELFGCGFNLYDQVGLGESRKETKIQKLTKIQNIPKGKIIDIKSGYFHSIMLIENENQNENPKRKLYSCGYWKYNGLGKDENTYEFTEIKSSLFENDDYILDFSVGNAHTLILTTKGKLFGFGNNLSGQLGTKYTNDQSIPIQIELPKLRFNEEISNYHISCGINRSFLYYSPPSFSNLEEDLIKLFKRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIDEIEFGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9P2</accession>
    <name>A0A9Q0R9P2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000082">
        <property type="protein sequence ID" value="KAJ5072116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9P2"/>
    <dbReference type="OMA" id="MLILENA"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052503">
        <property type="entry name" value="S100-fused_Epidermal_Struct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22571:SF51">
        <property type="entry name" value="FILAGGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22571">
        <property type="entry name" value="FILAGGRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="274"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="599" mass="71513" checksum="6FD08DBB08204956" modified="2023-09-13" version="1">MDNLIQNLNQNLIQNQNQNQIQNQNQNQNQNQNQNQNQNLIQNQNQNQNQNQNQNQNLIQNQNQNQNLIQNLNQIENEIENEIENQIQNENKKPPQKQTRKSNKRKKKPTETETEIETKTEDPVTQKIKKTKTKRSRNKKTRSKKKSKSRSKSRSKSRSKSKKKSKSKRNKKENKLEENKIEENKIEENKIEENKFEENKIQEKKIQEKKIQEKKIEEKKIEPKNVKKKQTKINDYFNNEIKNDPLILQQIQKNTEEFDGFWKSRADSILQEIEYDPDAQLFIFPVDPVVYNIPNYYDEIKNPMDLQTMRLKLSNNKYKTILDFYHDFMLILENARLFNSPQLYAHQITFTLENRYKPKFEAVQKELNQKIKQYKVVLKQIYKGIQQQKLEEQKLNEAQDNKENLEKDDLIEIEKDEIEKLDEKDEKNENIKIAITQAQIISQKLFKILDHLENLSPVDLYEKLEAQNPNIKTKFPSSNLFFPWNTTPFNTNFNFPGNPWNYPIYPKPKNEAQSNSNSNSNKNEKTKSRKRDKKSSRQDKILKQKINKLKREFLPGLLDIIRPFLPKNSNTGRVSFNIKDFDDETIKKVSDYVDKVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAD2</accession>
    <name>A0A9Q0RAD2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF16">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="1656"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="2018"/>
            <end position="2176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1758"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="499"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="954"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2112"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1762"/>
            <end position="1778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="2195" mass="259497" checksum="4B30ADD723E9C22C" modified="2023-09-13" version="1">MTQNQIPVTLITIKKGKPKLQYQDSNQETKEIGQDFESNHVYIFQFPILEQEKPSYRLYLENKKEKKKEFTQIDIKESKIIFDFDEKDSKKYGTRVIDAVIDYSSPSEKKILKKDQLIIFTDFLNAFSKKRFETKQSSKVTFKSKPENIAKILFVLGLRYSKSTLKKIFKESKKDDLIKCNKQIIQFYQTKEDPDAFNILTNFLSELNQNYKESKKIIFLPLFITFKKEFTNPNSIQQKDLGILFSFYAKYHFKLSELSKPVLIDIFGKSLNFQNTIWFNFINTIQKKELMINLFLIPNFQDNLKNTIFPNLLECFQFWVNLYNFANSAEMRKIRNLRSAIMQIASILPDIAGHSLFNQPCLKNEKRTYIEKLSDLITIFEDKSYHEYSNKQIKNNDERLEFFDKLDEKAKEFYLLDLTYDFQNVSKKQFLRFLPIKIQLESWSEHLLNERKKLEDSPFNEIIKNKEGLPKRWMNIIIIFLQFNNSNPKNNLLYPKNPNSNEINLAHDLKEKLEKYQEEIYNYFIKLQNPKQATINNLKNFQDNEKNLKKKILWFSIILYSISFLYKEKLTKNIESQENKDLSIGKILSDVKIEWEKWIENLNKDPNLEYINTEFPIAKEEYLDKDYTEFQTYNEQNKSEKKQFITKEIQKNRIQEFFEFRKIINRINPFIKFCEIFIQNKDDKELSNIKNLEQNWQQNKLSEITNLKQSIEKTLKVNIQILDLINDLFPNQDEKDQTIIEWIKEELKEKTIDNLKTNIQNQDITNDDDLNQTKKYLINFIDIFNPFFTKTFQNFDSVTEKISKIQKEMEENIKKINLKLLVKNFPLFKEQNIKELSDTLSDKIEKIFKNGSKIIFRLEEPIFQCQIKQEKEILNFEDFISMWRVALNKKNKSQNRAINENPTEDKEYSFFFRQFEILFETIQSINTYLEKFIPIKYYKQIPGINKEIEIKEDDNTYSEKMEELKQNINQALKNWEEDSKNISKEKLSGILSTNQLLLVSTPLLNIQEKNKVIYPILKLIFGKGRSDPQEILNSIISQQSDNWKNSSTGFFNLIKNNFTWSKIKNSLKKIKIKSRTNLSNELIKQINKRDGNISNPKIFIKEVKQIHLFTMKEQVLFCDSNTNVGDVKNFFSIYKYYNEEYSNFKKQKQKEEEKVIFSIINATLLSQTCQNEVISQIRSINFTTHFPLTIFVLEGEQNAFLMSQLQEGKLIINLENDKILNKIIQKSTFFHHFKVFYSQNEGDGKSYQIRKFCNSQNDKIDYKYYLIQLTTGEIQELIVELNKIPIEKKNENEELFIHIEFPTECSLQMTDSLWQLSMWGSIEDRQAKDPYNICWTLPPNAKLFFEIPSQNNIWKYFYPLQKFQPQECSCSVNEIKFKMYEVDEDQKKIQEIDDNDLKKVANLLIETQNNTLFNNFKDFDNWKQELSSQNPDTNSFFNKSQHIIQIISEQLNPDHNFHKSFRLFYQFWNSLKKFINPILDWEISDQNQNSNQNKNQNLNQNPFLRRQEIIRCWIFSVARLNLISFFSKQGKTFDNFYSFILNLEFENGNPVSIHNPNISGSTKEVGLFMNTNFPDNFLDFEGNLYSISQGRFGDPISNNLSNSEREYKQISEFFNFLNPNKSEEIFSNGIDTRKGKYVLTFDNLSKMMFIQFRMFTGFSLIISGETGCGKTALIEYLFRDILNYQFSKFNSEEELNEKEKEKETNHFITFNVNGGTTKEKIKKLLEKSKNWKTKSSKKIPSNIKFIAAINPYRERKSKAISENQNNENQNNENQNNENQNKEEKVCGLLFDYGDKKNKEQEEIRNAVYRVHKIPNSLENSVLSFESLNSAQEQVYISKMVDNTFYSILNNNDEKFREYQTIISSFKEYISKSHSYIRQDGDSNQTNDDFKRNLAALISLRDVSRILRVFQWLVESKAGIFLLSEKENEQEEEEDLFQKAIYLSLFICYASRQTTSKDQYFEAIFERNNNLLGNCKNVIENSQEKLIESLEDYDFSKKMIAKNIPLKENCLLIFVCVYAQIPLFIIGKPGTSKSISVEVIMESLKPPHEINNFAKKLELRTLRESFLQCSPITTTQGIEDVFKIAKSKTKKNDLGVVILDEVALAELSPDLPLKALHSQLEESEKEISRINQDNKKIQDIIKENGGVSVVAISNWVLDPSNTNRGILLRRESITQLGATSQQILCTKISWNEFNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAJ9</accession>
    <name>A0A9Q0RAJ9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAJ9"/>
    <dbReference type="OMA" id="XVAVCCI"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040541999" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="586" mass="68562" checksum="78BF336B75422B58" modified="2023-09-13" version="1">MKLFIQVLPLIFSFILLQSSFCDEQDHKYTPFQELTVWENTIVHGSNPQEKYEYHSFPFCSATKSPKHPRESLGEALLGNQLYDSGIKLKFEVDQEEMVLCSQKLTQEAISIFKNAIKYEFFYEFFVDGLPVYGLIGTMKNDVPLIFTHKNFQITHTSFQILEVDIVPDNPQEFYVGEDITFTYSVYWEEINGDFNQRFTKYLDNDFFKHKTHLLSIINSTLLMLVAVIVAFSILKRVINKDYIEFKKSDQSEYLQELGLGESISREKASWKELQEDVFRSPKHLEIFSSFIGIGIQISITSILFIIQNLFFSYYETRGTSMNAFIITYIFTSFFSGFFSGGYYSLNHGRNWIKNIVITTSCLPAIGLIIVFFVNFIAFIYKSVNYVPFGTIILLLIIWIFVVLPINIFGAIIGRNFNFFKSYPIRNVSEIERPKRKSRNSHVRLLIFSTGIIPFACILIELHFILSSFWSYRIYYVYGFLFLIFLILIISIACVTVILVYVLLNNEEHRWHWISFFASSSTALYAFLYSIYYFYFRTKMEGVFQIIFYFSYTTLICLIFGLMCGSVGFLSAYFFVRKIYQGIKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB25</accession>
    <name>A0A9Q0RB25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exportin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_08543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB25"/>
    <dbReference type="OMA" id="IEGCHED"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5073706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="938" mass="111636" checksum="5E2F5C68FC29FD9A" modified="2023-09-13" version="1">MQEKNQIFNFLENIFKQTLIPNNQETQKQILIDLDSFQKKSNFVTDLFNFLQQNVSQSIKLASILWLKNILKQHFEQKIQVAQNEIDFIKENILLLVFNSQFRIQKQLVEIIRIISQNEFPINWSSLLSELVLNLNNDDLGKIKIICFILHSILKKYKYYSMNLEFEKEINEVIQSCNSLFQLFNLIVENYSIQPVDDLIQILRLILKIFYSIFFHGIPRNNFKNMEELISSFSKIIINSNFSTDENFIKFQVSLIKFLKIITIRNPTEMENYSSILIEIVFNILLNTDNEQKFDKVFIYGTNFFSILCRKFKIENLKILQEDYQQNLFEKIIVPNINFTENFPINTNEQLDFIRWEIEGCHEDSLTRKGAVIEFVQEYSSLNTSSLNLIISLIDFHFQKYQENPKENWEFKNISINLLLSLWKNLDIDSVENILKEFILPEFENDGFDNFNSVLVLDSLKFIFTFKKNFSFDIFKQVLLVLIKILQFPNYAIQTYTAYVIDKLLFYISRKFSKNFKGEIIEIYYKEMLNNLWNIFEKENELNEIIMKAILTVVLLSKEFIFNYANDLFIQICRVVEMLIKNSQNSQFNYYVFELLSVFNSIVFERKMVSTEFVEKEFQMIDFTFFNNNEQLAEYSIQIASQIMEFFGNENQDHFVKFSNFFSFILQSFHEQIVSKNYSLIPCMNRFISSFITQFSIPYQEIENVFNQLWIIICKCLEISKIQEFGFELLLLISKQFDLMQFNQFIGEIFEKLLNGLNQCKISKYNRLFTIFVLDFIGKYETQKAIELIEYSNKKFSEFFEEIIETNCSQIEDEIDKNECLIGLSRMISEIDPFGSMNLVWSRSFILCIKILDISEDIIFNYESIDENEDENEDEVVFSLLIHAQRIENQEDSNGAEYFVLGTKNLLQNYSDLNLRNILEKLFCEEEMNSIEKALEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB69</accession>
    <name>A0A9Q0RB69_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB69"/>
    <dbReference type="OMA" id="LYTHMTV"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000616">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="278" mass="32139" checksum="D199B73C8D75BD1F" modified="2023-09-13" version="1">MGRKAQLVIGPAGSGKSTYTQTIQKHCELSRRTVHCINLDPAAEYFAYNPTIDIRDLISLEDVTEELNYGPNGGLVFCMEYFINNIEWFKKQIGEFEDDYLIIDCPGQIELYSHFSLMTKLIQEMQNWNYTVCGVYIIDCHFILEPYKFISGMLACLSSMIQLEIPFVNVISKMDLLGKQERKTVKKFISSNPQEMLRLVNRNNNPLFYKLNKAFIKLLQDFSLVGFTTLDITDEDSIARVLLQIDLTIQYGEDEEVYDTTNLPDENMDDFINQHLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBR2</accession>
    <name>A0A9Q0RBR2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_00993</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBR2"/>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="144"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5074364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="991" mass="112799" checksum="4D3D4CADF5BEF8BB" modified="2023-09-13" version="1">MVDDLYDEFGTYKGPDLSLDEQENLTETNENETQSRIEIEKDDPFEIKNENENNENENENENENESEDEVEETAIILHEDKKYYPSAEEVFGEGVEVMIEDEDANPITKPIIEPIVEKHFHHFEEKPETTFSAKFMEDLMNNPSRIRNIAIVGNLHHGKTSFVDNLIKQTHLKKWDPSIEYRYTDVRKDEQIRGLSIKSSPVSLILSDSKEKSYLFNILDSPGHTAFTDEFTVSLRLVDGILLVVDALEGVMAQTEVIVRQSLKEKIPICLLVNKIDRLILDLKLPPTDAYFKLKLVIEEVNTLINKYSLPFSDFKQGRLSPELGNVIFGSSRDGFVFSLKSFAAKYQKFYGSTVNINEFAKRLWGDYYFDQETRRFSRKPFYDDAERSFVEFILKPVYKIYSQIIGETPTDLQKTLDKINVSITKDEIKSNVQPLLNTIFKQFFGEMNSFVDLATEFFPSPQKNAQNKVMRTYTGDLNDSITKSMLECSKEGELMVNIIKLIESPTRQVFGCFGRVMSGTMHSNMQVRILGESYSPTDPEEMFTITTGKIYVCNSRYNIEMQKIPAGNWVLIEGIDHLITKTATITSTSNPKLSTFMKLEFETIPVVKVAVEPLTPSDLPKMNDGLLKLKKSYPILQTHTEESGEHIILGSGELSLDIALHDLREMYSGIEIKVSDPSTIFSETVVETSAIPCYAITTNQKNKITMIAEPLDAKLAAQIENGDVSPNWTQSQLSNFLETSYGWDKLSANSIWAFGPEMNGPNVLLDYTISTETNQELLQSVRPSVVSGFQWGTKEGPLCDGPMRNITFKILDSMVAQERSYRGSGHIIPTVRRSLYASFLTATPRLMEPIFLCEIILPSDAISVVYKIIANRRGHVIKDYPKHGTPFYVIHALVPVIDSFGFEVDIRASTQGQAFCSMSFHHWDIVPGDPLDSSIKLLPLTISTSQQLAREFMLKTRKRKGLSEDVNFNKYLYEEQIFELSQKNIHFKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBX6</accession>
    <name>A0A9Q0RBX6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_08081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NQNICEL"/>
    <dbReference type="OrthoDB" id="10255512at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="4">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="172"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="889"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5074726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1665" mass="196738" checksum="A510640BABAB7213" modified="2023-09-13" version="1">MFPRFSTTPSRFGNYDLLRTPKVSLKTQGNTIEGLNKENFELKLKIYYLEDELKKFIQDDEVDESYPQQIAELKTELEMKTNELEETDNLLKEARETISDLQQQLQETPTKKPAFLDKLSFSGLRKSHQELLQQSIELQKKRTSEVQNQEIDALKQTIQLNSENDTLKDMEIRNLNDRNEQLVSENQELTSQYEEISSQLEQLKEAYSQEKYQNNQKLENLSSQNEELSNQLNSLFQENQQLQETIENINQKLSQKKQKYQKNKNDLFSQIQQLTSQNEELSAQFDLLKTNHDKLDQENENLSSMIEEQTQYLEKQKQIALKLQNLLEQNKKKTEILEQDNDEKDQQLEQQNLENNEITESITSALQKLENYTQIIQEKNEKIREKEQEFQNLQDQAQKMQKEIENLSQKANQMENEDSSKIESISLLQNDLESKNKEIENLNSQINDLNQEKQNLKNEIAQLNENNKEFENQNNQISGSLENMKQEFQETYQELQKVILEYKQQALNDNQQIENQLQNIAKLEKDNQLLSENLKQIENQENSQFQNLQSKIKKNEEKKKELKQQIEKLQNQNEQTKQSLMKLEKQVGHLKVENQNLMRVKEQLLNLKNQNESTIKEYQQSHEKAQQYINELKQNQTHVFTNSERQKQDLLDLAQEREGLENEINKLKDMNRQKQNEINLLQSELIEAKNKIDELNENIQQLANEYTSKIQEIVGLSQTTTLNQNGWENQQNQMKEFFNSQIEKLQKKLNKNAKLIDELRKEIENKDLEIMQSKKDITNLKMAESQNNEYYEQAIDELNSKIAEKESILRNLNFESDKALQEKTSTIAENYQQELQERDSLLNIINDKLQQIVSDPNLLRSDLMNQQFKGLSSNFILLKTNILQKINHLLDYKLELERKKKEIDNKLSKFSSTVDNKLNEQKRKNEENEKRIKDLMSHLKALRELNQQKTQDLVSAQDMIQHLESEKTQAESTMLLLSQDVSSKTNKHENAIREINSLKQTRKSLQDKILQIEKHLNEKIDSQQAILKERNEIAQENESMQKEISNLQNECQNLQREYTKIESERDDLYKQLASLQEEKEQIENLRNEQISYSNLNKENQQLLRDFREIQTERNTLYSEIKQLRKDKSELQSDIQKLQFLVRDSNNLKSDLESFQIQIKMKEQELEEKENEILKLKMKQKQNENYELKLKDEELEEKENEILKLKMKEKQNENEILKLKMNEQELEEKENEILKLKMNQKQNENENYKLKMNEQELQEKQNEINSLNWKLQNQQSKLKELDELNQDLETENNKLNQDMNELQKQLSIAEKKIQEALNPLPNSTIDSNSQRSLDLNSIQNPDSQKGIFSNFKSKLSTLSKENQPKSTEMNYSSPIYAANIQSNQKPYIERKSPTIPNYSITKNLKISPKLNENPNPKNLNNYTHLYPNSLSSVPSEFDNLSFQSDLEEEKLLERTQGSPSKLENELDKIIIDQVEKMQKVMKKSHDKLEKNRLDYIKEQTKKSKPANIIRQAKSAITGINKPLSNLSNKNNLQRNFNQEFQSPKAINPIRNHSNFNFQTGIPKTEPKIKLKPLFNKNSFQNDNNLNQNDNLILESNSFKSDEFTSNSPIPIRIKEQNEQEKKYFPFQSHLNSKTKEIENDPIEEISKLSKGLNFLQNQLKQYSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBX7</accession>
    <name>A0A9Q0RBX7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAj domain (Prokaryotic heat shock protein)-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBX7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="568"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="735"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="806"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1263" mass="153827" checksum="FE817A65C86CD34F" modified="2023-09-13" version="1">MQSQINQIDNIEQFIDIWKPLSSLFIKKKQQKEQQEIISLLKKHFDKLISNLISNLKSKSKLNPKSESFFEHIISKQILQNFPYFIDVFKEFVIDIYSEKLIQTTFHKDDLQKIPKEIEIKAWEEVYNKKKFLKFNYDHNQQKNQNQNEFDFILNKFDKIKEAKIEKIWIYLINMNNEFQPKYKGNPFNYLSKDFQIIEKIKNQIENKTFELKKYEDFIQDNLSNLIIEIFPGTNFKEINKEIKKFKRNQEIIQKFNQNYLYSKNINISPNLNQKIEQIPNILIKDISNYFEIPKEIIERINEYTSNSIHESKWIKENFENLIKENQENRIIEIIENLDNELQQIYNKFIQKQFTLKEIEEDYIPKLNQNQNQIEKEIQIEIEKEIQIEIEKEIQIEIEKEIESLHYVVKSKNENEKQQFKEEIINFSRMNIFNNYYEVFKFFFEKNIKKETNEIKDLTKQFPIDKNQNMKVITEISKIYKPFLKIEHNFLKFISYIFPLNENENQNQKENENEKYSQNLFKFIEEHLIDWKEIIELIDFDFYAYSESLNFIKNGIIDLLGENSQQKSNDLKSFIENLEKNKSKWNNEEFQQKQKQLSNQIEDIHKKLPEIENLIKLKLQNPKQRAKRNLDVILNNNKIFKFKIQDQVEFSCEILSKTKNDKSLFNLEDFVEIDMILVSDEKNEKNENENEKQKVIEFSKYFPDIYEMIDLLTNLKTSIHPKYKKDYSTKFNFENNSIQKHLEEIQKYNQKLKKNKRKWEEFQKEVLKKYYYSLFLSFDQIKIFYNLLISKKSSKITNKKEQFLSFLNIENNLIKWERDKEDIKNDFKLFIQELHQIIEEKQKQKEEKQKKKKQKTKKQKQKQKQEEEIKKIEKIFLKEVIDEKQPIFVIQIEEEVKIYEFITILYIKYTGNFPKKEQILFCNKNTSEDDIFRFIKLFEKSININEKEIFSIIFAHKLPKKLQNLLIKQIQKVDYSNENIINSTPNQSSKSKSKSKTNYKRILLLFSLKDTNETKKYSSIFQSNLNQKEIENTFDLNENEKEKEENKREIIVEKLKKTFPKRYENMKLFISKFSSTGKTFQIRKHLFEINEKENEKEKYEYCYINVKEEEPQKLIEELINYDNNNNKKCFHLNLSYFIENEICEIIWIFLIFGIIEDKRCFNSDYNSFIFKPEKHLILFEIPSNQLKGYNYGLNKFTPLKMIENFKCEVNEKTFSKYIYEIDSNQIISKKINEKMMKCGNFIDILYEKKFKNFTLETKEKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCC4</accession>
    <name>A0A9Q0RCC4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000067">
        <property type="protein sequence ID" value="KAJ5074994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCC4"/>
    <dbReference type="OrthoDB" id="114080at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="294" mass="35469" checksum="1CCB06D2E350E54E" modified="2023-09-13" version="1">MNSNDLQFYSILNSIESKFNWEFIQNNSQYLFQPQILSFHPKKLLKRKDFHIFYIFLKELFFEFKEKTNQKINELEGNFQLIKKLIYTKKNQHKKTKHLQKLTEVKKTLQRLFELNISEFAFVFQFYLKFINKSKTLQMDFVDSFYLLGEASKCLNYQLQSNQNLKNKKKPSSFQELFLFKQQFMQIIEMPLERFLGTEFQRKKNLLQLKNCAIKYGNSSVYNHVFSTENEDLGEFEMRKEESIMKKEDSIKQEKTIEKWNISTNNQNENQNENQNQNQKSKSKSKSKSKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDF3</accession>
    <name>A0A9Q0RDF3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="2">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_08024</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NYDMYIL"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032060">
        <property type="term" value="P:bleb assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050920">
        <property type="term" value="P:regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08380">
        <property type="entry name" value="C2_PI3K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00891">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000008">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035448">
        <property type="entry name" value="PI3Kc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF14">
        <property type="entry name" value="LD28067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-RBD" evidence="10">
        <location>
            <begin position="431"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="572"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="848"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5074669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1380" mass="160116" checksum="179DBC6230E3A1E3" modified="2023-09-13" version="1">MSITILLEFPNNEKEYIEIPYNSTLMTIRNLAFHLKSLDPELMKHTFFKFKNIKLPSSYSKLIQCSNEMRLYVQYNKPIPLQMVIDKNHVEEFGSTIQFTNSLNIQHNFQTRTVSTNRNPIQTETAKNISPTREMKQKKVVQIQKSSYKFWTGTFPIKVVSLNGTSRILMVTASQKTSDLITQLYDLDKKAFHNWQPSDVVLIYEKFNQKKVINGEFSEIPEVFSKIQSFQVPVLRLMLRSELESDKKKQTNLKQRKTLIPSHSNKTNDMIIKCITPGKILVSASISKTQTIADLKKEIYSLFSRKVAQSMRKKIDFFILRTIQDNKELDEKSLVIEIPIIANASRTNSFSQPPLIEMMEKPSKLTKQEKLIRMEIGIILDKSLAWTSTEDESFTMRQAMEKVRIQSANILQENYHGDLILNVTLARSPLRKNSLMEKPFSFMFPDMTKRTLKCDVRKKLPEILEELFSKNTRSLPENAKTSDYFVKVIDSWEFLSDTYPLHKFEVVRSRLSNPSSFVQVALIEKSKLREELSDPVTENTNIIKESLQMIEENANTEIENSKEITSFSVLDIESPLRVRIVGIENLQPQQVSLSDVSSVFVSAGIYHGGKLLCHEKHTKEILPSTTLRWSQWLKPEILVCDLPPATRVCFTVFGKNNAKLVPLGWVDCQLFDYLSHFRSGVHAFNLWLDAQANPIGTCVHNLSTRNPSVLYIEFDTFPLPVVFPKINFNFDSLMQSLSKLDSNSNSFSEFEINESETTTDQIEIEIDDSKFIQQESIHRLSEEDKEKEKEKEIQIDGFEIQTEIDDKDQEMQIVRIDLDDQNNDNSEKTTQENMEIVEEFDPEFSNSIAKVFNCPKSQFKLMKVLIDKDPLYQLTPRDKRIIYTSREYITKYPQALPKILRSVEWNKREQIKEAMSLLEKWTPMRPVDALELLDSYYSDNNVREYAVTCLEQMDDQELEDYLPQLVQVLKYESYHNSALALFLLRRALLSPWKIGSIFFWYLKSELHVPEYSERFGLLIEGYLYGCGFHRKIIFNENEGFKKITEIAKQVAKLKDHDQRMALLTKQLNTFKFPNRLFIPLSSSWTADSFRVEKCKYMDSKKVPLWLVFGNSELKTSTYSIIFKYGDDLRQDILTLQMFRIMDQLWKENGLDLRLNPYHVIATGDMVGMVEVVLNSKTIATIQKDSGGGVAAAFKKGPLYDWLVKENQTEEKIRKAIENFVYSTAGYCVATYVLGIGDRHNDNVMLQRDGHLFHIDFGHFLGNFKKKFGIKRERAPFVFTPEYVYVMGGKDSKDFKKFVEISCKAYNIIRKKAHVFINLFSLMVSTGIPELQCIEDIYYLRDAFSLGLTDKEAALKYEKLIYKSLNTTTTRVNNAFHILVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDY1</accession>
    <name>A0A9Q0RDY1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDY1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040344758" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="415"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="698"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115312" checksum="65F0BF2943C96AF0" modified="2023-09-13" version="1">MKIKQLTVTFFLVLVFLAFAKQTNDFATNSNTQWEMIANLTQQTSTTTFGECVSIYGDFVVIGDSGDSAAFIYQNNGSAFNLEQTLNITNFSSCDSIEISNLFLTIVDSGNFQILIYYYNGSYWNLNQTLIGTDDHFGESVSFTNKYLVVSDPHNSQVLIYYYNGSYWNLNQTLTSTNGHFGESVSISNNILVVSDPHNLQVLIYYYNGSYWNLNQTLTGTGTDDHFGEKVAISKNNLVVSDSDNSQVLIYYYNGSYWNLNQTLADPSSSTSFGDSLSVSNKFIVVSDPDLNQVFFYEFNGTYWNQKQNSFIYQNLVIPQVSLINCTSLFASFECYWDEVELPTSLKYQINFETNWIDINTPLEQGDVMYKLFDSSFDSMIKGNINYSIQIRVCDLSNFCGDPSSVLSVFTRIGSVQNFQISNLTTDFLNFSWNSPNVPIINTIPDLDHYVFSYLNETDKIVTNVSLVNSITSFSLDNLQCGTDYNISIWACRTLLCEGDDQGEILELSVITKFQEVTNLSCSVDGVNITCSWISPGNCTEIPVYYNLTFKSTLDNVTGIIQANYTDSNFILDIPNQQFEINVSACDSINVCGTILTTSITTGNLSAPTILNSTSEIEEIELNFTKVNQAVNYAISLDNGTNWINFTSINTNGTNVIGTKNLLAGNVEYLVSVRGCADLSCNLASFGLPSLSTPIIAKLGNISSLKCSSTSSEFYCEWNPLSLSEGLKGYSFSYNSTSICLSNSTTNYSVSNLTEGEIYIISVYASDDSNCSLNQYSGLPSTTSIIIQQLTAPTILNSTSEIEEIELNFTKVNQAVNYAISIDNGTNWINFTSINTNGTNVIGTKNLLAGNVEYLVSVRGCADSSCNIASFGLPSLSTPITAKLGNIPFFECIPLITGFYCEWNPLSLSEGVKAYTLSYNSTSICLENSTRNHSVSYLKGGETYKISIYASADSNCSVNQYSGLPSEVFVTTFLPTPTPETSTGESSPLITKIFIGVAIPLFGIVCIVALGVVIKKYCARKRKPKHATKIDEQEIDLENDLEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE13</accession>
    <name>A0A9Q0RE13_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE13"/>
    <dbReference type="OrthoDB" id="297375at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="453" mass="52138" checksum="C371B4640C1F5656" modified="2023-09-13" version="1">MNEIIFFGKNEFPKLIKNEKEIITKPIQFKFKNENEKQIKQISSSYYSTIFLFENGKAIEYLNENDSKPNPKKIQIKENIQKVTVGYENEAILTTEGNVIAKGYNINSNNSNEIINISLLIEDPNDRIIEDIISGAYSIYLLTSNQNVYGIGSNQDDQLGFDSETLPETQKPILMMKNVSKIFSGNSSKYVFLLNLNQELFGFGDNRNGQLGLGESIKEIRIPKLTKIKNIPKGEIIDIQCGFNHSIMLIENENIKRKLYSCGNYKYNGLGKNKGNTYGFTEIKSSLFEDDDNILDFSVGTDHTLILTSNSKLIGFGNNYFGELGTGNRKNQLIPIQIELPELRFNENISNYHILCGYYKSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTKNEEIIEAHKLILKYRLNQNQENEIEKLQEIISNKSIKESNQIFEMIYSNNSKINPNIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE37</accession>
    <name>A0A9Q0RE37_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE37"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5076749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="109" mass="12738" checksum="2B94CA020B55C927" modified="2023-09-13" version="1">MLNQQINSEKPGLVLENLKKNQKNLTTFRLILSCLIGSIIGCLKITGVLGFLIFLLSNILVYLFVGFKIKFKFENYFVSQIQMIFESLITSLFAFLLFWTLIYDYIYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REQ9</accession>
    <name>A0A9Q0REQ9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REQ9"/>
    <dbReference type="OrthoDB" id="6418787at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5077427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="98" mass="11408" checksum="A0EEBBF392116438" modified="2023-09-13" version="1">MRSELYRGMFLSVKNDTPNKSQYFKSLFKSKMKEYQENKLILQDVSSSILSPILNYLYSGKIEINSENAIEILIFSSKYLIDELIGITSNFIKKNLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF35</accession>
    <name>A0A9Q0RF35_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rabenosyn-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RF35"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="522" mass="60254" checksum="84BA84F9438036D9" modified="2023-09-13" version="1">MNYCTVCNKHKPKGHHCKITGKFVCFQCIITVSTNKPGFNCPSCGGEINLIPEIDPNQKIKSQMCDFLKKGWCHSYQHVLANDPEEHPPNRIVCPNFYKGESCHNPNCPYTHPRAEDFLEWRNKILKQKSKYCQNEIDVYSTGDWDYISAHPNPNDNSGYYDNLGKFYPYPDHSSHSKRCQYKMCKYEHKKFPSELKTELNDLFPQQNQDNRSGYNDDFIPINSLNFKHYYAIDDSYKSEKQPKAKEKKNMERRKEKRNPKSKRKKKHDWQHNQRKLTDNTKTHQIELDKHKISKNQNQKSKSTGQSESSDSDSTKSSTSDSDSDSDSDSDSDSDSDSDSNSEKQNQDENLQNNQNGKKKDSILDQTAQQNQKENKNTNQKTKKQQSKSDSNPNSKSNTNTNSNLDQTNDQNQNKGNQKSQQKLKPISNSNPNPKSKSNPKPNSNLNSKSKLKSEIRIKPNSNSNPNQKTKKQQSNSKSNSNPNPKSNSNTNPKIRSNKRSNKRSKSKQNKRKENETRRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RF97</accession>
    <name>A0A9Q0RF97_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_06109</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="342"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="910"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1240"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1307"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1506"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="778"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="910"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1240"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1318"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5076529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1915" mass="224916" checksum="C405EF44F869C3FD" modified="2023-09-13" version="1">MDSLINFFKERVLKSPNRILAYLISFVAGDYLSEGINYNNCKPIITREDFTLDLENVELSVDTINQKLKDLSLPFILINGSIGKIKASIPLTFEKCEIQVKKIFIHLKLSSFQFDLKNQNHKNQNKNKNKKIIEQEPGFFQKFIKNLISNTTIQIEKFTLIIEKDSTGLESLNFSSDLNAYFKLEIESIFLKQSTFSEYLLLKNNNLDQIDLSFETEENSENNSKGSISRNIEIINIQMSFKIDSNINSQNFEKILTIQEKPTKLDIFSIKEPKKEIKEKNFFSKLKSPTRISISFGKIQILLNLQNLKLFLLILNQIGNQFNQKNRHDKFKKYIEEEKKEISKTKYEENENESIDLDENENENENENENDNENESENESEIYDDDSIYDNIDFDESNEEINQEINQEINQEINQEINLDKNLDSDEFESFSSDSDNQNQKSQSPAFSDDDIDAIMDFIEKQQMKKMNMSFSQMNSMSSFYSLDSFNQEDFEKQNEKQKSLKFLLDLSISKFVICFTDEKSITYELLKLNNYFKIKFSKIHINLEQGMEFLFKISLAYFNFSAYSFKFNKQKKHEIIQFQRNQNDDKLKIRFHFEFIDDPKSNESKIKISSDSLQFFIESSIIIWIMKIWTQIQPIIQNMKKNSQVDQEKRSDSFEDDSYNFYNEDQEKTKKIIHIKGDIFQFSVIVFINEELQFVLDLKKVEITSEDVRHHILFEFHSLSGNISKLRDLTISDEFEDKSFLFNNTNNTNKNHKYDLENDILNLSQEIREYKPDPNLENTQENQSNTNNSEIEITPENNFLITSTTYRNGEGNNAKINIYFNKFTSNQQIEPARHKDEEQEQASKFYGKYPGFSIMNEKNRISFHGYLLQNSLISIDFNFPHIELNFTTNEILLLIDFFSIIKNKIFKSKPEKEKENQKENQKENQKENQKENQKENENENENELKFLPTKLSMFITFDEFLISISESSQKQFPTALIPRKHSFLLSFFSTQIYFASQIYKEKCNYFCLQTEEFAFEDEEYDESSKNKENKYVILSKAQSGSLKSEQKMIKFFFIENKSPKMISQKDFSSESIVSLKLKNLQYMHVIRPETLQRVINISSLITKKSSEILFKKNQNFNDDFPDESNSQQLINKEVNMKSQALHLMITISNSYICYSPENANFNALIRIGSFHLFQKIMSLSSKKSISISLEKLKFYISNQQKERLNNLYKCFDYQDLYDFVEVMSLPKLTIDLEMKKENQNQNQNQNQNQNQNQNQNQNGSFLKANINNETLEVNLRCDSLQAIISVIDHLNYLVDLPEEYRPIVPEIQPQNGKPLNDDSDLENDDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNDNEKNENLFIKNQKIKNFNQEIKLFESINKIQENKAIKTIKSENFIVNWNEEEVIDNIGVTFRDYLNLPSQWPPEKEKELDQYRKNAKVIIQFTNLSAKVNLFDGYDFVLQKERKKNEKLKELRNSRSKMIERNEFSIKIYNYPNEENEANLNKENEKAKELKIEKQSIISTDHLEFDLNNIHGTFFLFPRKSLFKFALDFNVGEMKILDHISSSQYFTLFNYRYHHGLPKDKFRSLIHFMFSAIYPNPESQTQIKEATEEWRMSLFILPLRLNLDMRVLDFITRFFSFRYPKTFEYLEVKKPKPFIQEFSINALEFEICLTYTLQGEIAAEINDVYLKVPGIKIIGQNGLDELAQELKNHYIKSLKQKRRILSVAGYLPVIGSFKNIGKGLKEFIKKPVDQYRSGGSVLIGIWKGTESLTKAILLEGLETGVAFTDFSQKALDLIKKNDKFSRISMVSAEQPSNMKQGFKKAWKEISSGFNEIVDSYTTSDNDQKHGFFKRIVKKGTDASLIPKTFLNAVYYSLIGAINSLDPEHMTKSDKKFKSVKKDSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFT7</accession>
    <name>A0A9Q0RFT7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFT7"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="126" mass="14893" checksum="0EDFF5DDBC6A7CDE" modified="2023-09-13" version="1">MENFKHVFIFNIPEDVLKEELLEILERFGPVTSISIQKLDQETQVKYAIVEFQSHLIAFNAIRNLTGYIIKNHALNLYFFDIIEMKPVNIPPNYSPQSTQDNEIEQNKQNKQNEQNEQNKQNQLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG64</accession>
    <name>A0A9Q0RG64_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG64"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35310">
        <property type="entry name" value="CELL WALL INTEGRITY/STRESS RESPONSE COMPONENT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35310:SF1">
        <property type="entry name" value="CELL WALL INTEGRITY_STRESS RESPONSE COMPONENT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="723" mass="86872" checksum="AF564F23BC84B2AC" modified="2023-09-13" version="1">MDSDSNSYSDSNSNSDWMITENSNSDSDFDSDSNSDFDSNEYQNEYENEYENENENENENQYINQNEYENEYEYQNQYQYQNENENENQYQNEYEYENEYENQYEYEFENENENENENENENQNQNQNQNQNINQNEYENENENEYENENENENEYENENENENENENENENENENENENENENENENSRMITENSNSDSDSDSDSDSKSDLEPIELAPNGPEMEYLKKLRILLIQKKFDECLKEINNCTLEPHQLEQIKPLHILYQIKALVGLGRSQEAKKIIKKESKNFFLRFQLAKIYYKTKSNNMEPINEVLSLINDSNISRNSQTGLVDSSVFHPTRKDFLILKIKFLIRNKEFDLVSKELEELNNEIEEDKPRLNELEQSNNFIPDYESITETKFALAQNFQKLNQTNEWQNLRKQLRENQIIQLLFKENLLKLQVIQQKSIIKLYQYKTQILSVQNIYSQIKQLLRANPRQDIQNKLNEMEKNLGLIPDESFTSNYHYYWGVFYHLKNLHSKAVQKFLLAHSSNPKPKYLYCIARECYLDSQYTEALTYLKYIKWTKPNQNLQNKVISFQKYLQECEKIRQKTVSKSLLNSEQNFKYLLEDLETDFVNKVLKFISDLQREQEQKQNREEKLAIFLLNLQEQSREYILRIFVNNLPNLQEASRNNLLKNFNSILKNFNSILKNLSENLQQEYQENMDGITNQFQRNNTDIFIIRRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHR8</accession>
    <name>A0A9Q0RHR8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_14185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000014">
        <property type="protein sequence ID" value="KAJ5080098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHR8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="92" mass="11470" checksum="D3E04F6D8E0E12A7" modified="2023-09-13" version="1">MLLLLFQRKTRRTLVLFYIEVPRFEFHIHHALVLIIQRKIWCVRMKLFQNWQKLYNYEKTRSQKIQETDMEGRTWIESQQRNGIPKTNTARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RIT6</accession>
    <name>A0A9Q0RIT6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Microtubule-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000013">
        <property type="protein sequence ID" value="KAJ5080114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RIT6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="613" mass="71126" checksum="D133DD149F8B0D4F" modified="2023-09-13" version="1">MWQDIKAIPTDLEKLFFASKARIIIPEKITENPLDDLQKPPKQRIFFGQLVHFYIHLKCPQNMASREKEKWDQLLNMITIKSHIKASYRTSSEKIESPRSPRLKTQKSLTAKKKSNSKLIKDSEKNKTAMKMFTKSQDLSGDMGNITKHRRHLSDYRTNSFDILSPSKSERNLAKQIKTKSTREKKSAREENPAHLLGFNSETQIEKQNETHTEFQLSNGDFLIARSIRVVQNLYESEQQNITITAKIYFLENKQTELFGKLSAKELEKMIGISEKKAFGPYGPNPEFVIRKINKHLSVDFPFNLTSSFCSFGNSTMIMIVIENVHKNSALVLHNPKFHLNPSFQSRSPLEDMEGNEENKNKPIPQKRINSFLFGEAMQIQELVELFCVNEIPSKDKSINIKFLKPNEKMSLLYRISPVSSTLVDDRYLYFHGKFTSLFTVSWQITRQKTAMNIDQFMQFPQNISKHQIQWKKELVSDVQIKIKNPPLANAYSLFEVQVEIVNNGKNFREFQLKIPYSKFSSNFEQKNFQLAKKSSSQNDKKIFDQFQNNLNQLEIVCQENSIHLIIQAKSSVFVNLHFIAFKVGICDIFLELVDLGLLQRLVAQQSFKIQIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L4Y8</accession>
    <name>A0A9Q0L4Y8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase rnf213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L4Y8"/>
    <dbReference type="OMA" id="EECNTIS"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF1">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1227" mass="148289" checksum="14C5AD57540FF1D7" modified="2023-09-13" version="1">MGKTYQIQKEIYQKSQENQNKYFQIFITNGNPIEFIEKINEYLNKINYSAHFKIDNPENIIKYLHIKLYFLPNLKMMNLIWNLIIWNLVESKRKITNNFIWNSDPSYFFAFEIPSNRKKNSENGLNDFPLLKWLEEKQCQFSSNEFSFTKYKLNQSFEIIEDDEHKQKMNEVAQFIKQNIDYFQEFENRKNIKDEKETFKFIQKRFSEKLPGQPLTYRLIMNFTQILKKNIDFLKDYFSIENFQNKDETIMKKYFGNLLKFYFFSIINIVARFLKWSTKDIDSNSNILEYFSTLLKEKVKWEDRMLYLPIFSNIRKNDIEMNLISNQKIKNLFDQNIQKYFDKKLNFYENDENDKNDKNNKNNENDKNDKNNKNDKNDKNDKNDKNDKNDKNIKLFHSLNPNPNQNLNLKSIIENENQNQNQNQNQNQNQNQNQNQNQNQNEKIREFIFNPINIMKLLYIQFKLFAKLPIIFEGGNKKERLIMIKYLSEEIMKQKILIQKIKPTTKPEEIINIITTAGNYVTSSSEINVFFDEINRGSKECIILLKEILLERYIKDTRISNQINLLASIKSFSVNKYNKYDSKDLNKNKYKRKEIDKNIISKLQVIPDSFFEDIYDFGKPIESEESITSLIIYKVLEKLEIFKKLKENSITKSVNLLIKRLFLFYQDYIQNENDENLNLNENENENLSIFLKIFKWILNNEIDIKLENENQNQNQNQNQKEKENDIEYLFERITKSILISLFVVYKSKFKPKLNKQQFFQNLKEYLKKYNVGEIGEYFQKINIQKYLDPMIENLIEKLDIKDKAEKKHIGINQRLKENIFFIFICCFSQIPLYIIGESGSSKVTSLEFILELFNQRDKENKPKFSLSLSLPHLKEFEIPSNKLIESNKIKDIFKKISKEIDENTINVITLKEINVFKKKIYRNESKIISKQFVQILKGRKPSNQIYGIQDYYSFIKDIDIQFQMNNKKQFSDIYFESLFKHFGIRENILNNILKHIKTFDDIYSRFIFNYQKIYNAIYDLLKQNYKTYIYSLINEKTEKINIHPNFKLIIITSKAMKYEFNQPYLLSFFEKYYFDLSYFQNLEKYLNLKQKIETELIKPIKKIQKNEISNEELIIGYNENLIYSLILKYQKEEEKEKKILKLMKNKLIEFFKIEQMIEIYLLNQKQEPQKQKSSLSKTKKEIEIDQAQKKIEENIKYYFTKFERGFSELFQEEIVKKEKKKWIIITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L543</accession>
    <name>A0A9Q0L543_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000143">
        <property type="protein sequence ID" value="KAJ5066427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L543"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="117" mass="14120" checksum="C904F09AA3862D6D" modified="2023-09-13" version="1">MEEQIDLNYFEETFNQIAESCLSMYDISNIEYDFSRIDQKHKNIKDIDLVINQNLEEIKKFENQLSQDKQELNEQIDKELENCNKLKEEAKQIFPDKSKEEPKQIGFSFFQIFQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5B5</accession>
    <name>A0A9Q0L5B5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="9">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_03516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5B5"/>
    <dbReference type="OMA" id="VKRCQCP"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="5"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5066183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="346" mass="38842" checksum="B370A63963928BE4" modified="2023-09-13" version="1">MITELLKKKHSDYITNVGVRQNDYEYRVSEQLRVSGLYWGATALVLLDLDPHDLPVYFNKEAESKNFPEISKEKNEENNIINFILKCQHENGGFGGSVDQDPHLLYTLSAVQVLILLNEEHLLDAEKISDFVASLQQSDGSFAGDIWGEIDTRFSYCALSCLSLLGKLHKINLEKAVEFILRCKNFDEGFGAIPDAESHAGQVFCCVGALAIANALDKIDFDKLGWWLAERQVKENGGLNGRPEKKSDVCYSWWVLSSLSIIDRIHWIDKHALIQFILNCQDSDDGGISDRPGNMVDVFHTFFGLAGLSLMGFGHLPNIDPVYALPVKTINRLGLKKLFHSPIQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L694</accession>
    <name>A0A9Q0L694_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L694"/>
    <dbReference type="OrthoDB" id="3517218at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1240" mass="146314" checksum="80474A3DFCB57EE3" modified="2023-09-13" version="1">MSFEIPTIQKFLEQIKDFNSASKIKTITTLAVKVKSTEKTEELTKFDNLLIELYKRKSEEKKLAVFGAFHAKRKDLLVQFLKDEESISFSSKILLSKMIVSVLDPNSEEDMKKLKELIFNLPTKLRNILLKKVQTKGFKKFVNENFEEILNRFGESSSRQLIGLLDKDKFNKFFPQFYPFFKENGKFAIIQSIKINPDIIVSFLTEKLAIAPALQLPQLWQEYQLIFKQLMNTNPEKFIDLLSKYSPVEEIPSFVTPRLKTLFKVNNEKMIEVFMRPEYLEKQRKSWRYQSTIITKRKINKKLSKDDLSKICQFFKESELRKILANLPPSERFAAYEDAYKEEPDDQIRDEYILLLLPIEHRINEAKKMLKIPAINQDEEKKRNFEKLLDIKEQRAVYEKEIKEAASAEERGIFYSYYLICSSLSKNAEEIEKTLKFIVPRTKNEQEPVRNQIVNALKSHAIKYLNESHIELLKEFLKNAMDSRDASDSLNVLIDLFVNLIEFNYKKSKTHKLLKPDEKESYDDAFAKIPFIKFCLDSLKKLYIAQSYISYLTKKLTSFEVIFRAAFNFFNSGSTEAQRSFFSFCRWYPHHRWSPWMQEQIDKFLENLYKKEDLNNDTFETSIRFYLFNRKYKFQRIESLLEKDTSLLNKTGFLKELLLHRQDLCDKYEIFENIPLDQRKIPIKGKIDISSLKQESVLLNVIEIISESKKIARRISIENQHKLFDFIKKALVEIGEEKDNENDDNDNDSDSDDSDDNDDDDKEKKDEVNYKYTKDQKREFIKAISNLDILKPSDAKELMDILKDQELIFQDLLANMINLDNYEGLLDLYVPYVNTDYAKIVMFSFLKIGTLSSTKEIQKVVNDVLKIKDLKVTVRKEIYRLLGFYKFPETKELLFNEYSKELHPHAKIALLNMLRSKFLDEPKTWEILDKEIQSKDNNMYEMIIAQKYTKIPIKYLLKYVTLFEQIIKFTTKASVLKSVFTQLRNWVRPESMETTQKVIEICENTILNMESKTEWVLAFDVLLYAAQCFESSALSLKKFILKLLNLDFSKDLEIITKDKDMPLYQRVDDCLNKISNIPHQNLNFLESANFFTEVSSFILDKKLYPFFVFSGQFKFATLEIDVEKFTKIFSQVESDFKQYPFFLDKIINWVAKQYFYNRLLPGMESISVDIIKKLFEMGKDNRNFKIAAANILKVIGPKTKWIDSAIEILAQMRKDSDLEISSISSSILLFNETSQSRNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L757</accession>
    <name>A0A9Q0L757_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase wbbk-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000138">
        <property type="protein sequence ID" value="KAJ5066645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L757"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46401:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE WBBK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="223"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="431" mass="50505" checksum="DB8644665731A0C7" modified="2023-09-13" version="1">MNIGFISTRIFGTDGVSLEISKIQNLLIQKAKKVFFMAGELDPIFEKQENGYCFEKMHFLNSEIQSIQKTLFENKLETITTKQMQECWDKIDQFANEIEYEIEKFINKFNIHKIITQNCLSIPMNLPLGKAIYNYLSKTGMECINHNHDFYWERERFLNIKNQNLQDFLDKYFPPSIPNMKHLVINSISQETLLKRKGISSVVVPNVFDFSQKEKFIDEYNQDLRESLELEKDDIFILQPTRIVPRKSIETSIEIVSRLKDKKAKLIITHSSSDEGDDYLAFLQQKAKELDVDMRIANSRFSETRGINQNDQKIYSLWDAYLFADIILYPTLIEGFGNLVVEALFFKKMVVVNKYPVYLKDIKPTGIKFIELENNQITDETISQIKEVLQSKKDPILKKKYDQIIQKNFEIGIQNFSFEILSEKLKEIGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L783</accession>
    <name>A0A9Q0L783_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000145">
        <property type="protein sequence ID" value="KAJ5066368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L783"/>
    <dbReference type="OrthoDB" id="3022198at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="219"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="360" mass="42504" checksum="0946CBB46BE457F3" modified="2023-09-13" version="1">MDTKKIFNFQLNKTGNVYFPGYSYEPRVVIQVLLLLSENLICEIFKDKSHLTFAQMEEILCVGHSYIHKLNQKFVKNVAALFSEKVEMMVEEDFHYIFVEAIIKTTEKIIKNSHKTSNSKKKLTLTHEEFIKNEIKKQPSIYIREIQSKLNEEFSLDISISSLYKYITNQLKYSKKKLSLRSPRKFTEENKHFHAKFKEYMKEIFDLFGDNNVIFIDEVDEKHRINSICALSNNGFVCMDSYQDSINGVKFAQFMIEVLLPLLSESSAVVMDNCSIHHSVDNLVKGYYQEFNHLIIYLPPYSPELNPIEMGFGWLKRTLASYRKEFLENPFQTWQDLVQKFNSTQDAQCYFEKDYEFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7F3</accession>
    <name>A0A9Q0L7F3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_13208</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000133">
        <property type="protein sequence ID" value="KAJ5067159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7F3"/>
    <dbReference type="OMA" id="AYLHYRF"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="117"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5067159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="243" mass="28923" checksum="D2C64F6E54A4AFCD" modified="2023-09-13" version="1">MNNRKFQKKTRSKNKPNQPKKRSKKKEKLKEELEFMKKIQEKLKLANEEKDFLQYFPRYTNYNKNGVNIKMEFYKEIPKENKQEIIDLLRSNMKVMYEEADGWGWNESQKFNELVSEEARFLVLKKIDEKNNDQESESKGSFAGFAHFRFVEDDKRAVVYLYELQLVPDVCGKGIGKFVMQFLELIVFKFNLNGLVLTCFTANSRALNFYLNHMKYSIDRTSPQDSLDEVSSYRILSKIIRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7I9</accession>
    <name>A0A9Q0L7I9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Iron hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_12870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7I9"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000035">
        <property type="entry name" value="Iron hydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="entry name" value="Iron hydrogenase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="262"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="302"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="10">
        <location>
            <begin position="373"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="505"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="968"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5067518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1115" mass="124929" checksum="43298112406D08BD" modified="2023-09-13" version="1">MNTSSNNTQTIEPLFQVEAHESAINSIEVSTDENQFYTCANENVIKCWDFDTGKCVATLSKHESFVNSLNIHKGILYSCDIKGVLISWDVMNYHPLTIFKGHEGKVSSFHNRNDLLFSGGVDHTIKLWNTSNGNLIRQYLAHTDQISQLYATIDQKRLFSSSMDSQAILWDVENSQQILTFKGHQNWVLSMAFDEEKQILYTGSNDCTIKSWDTKSGKCIKTYEGHEYAVVQLLLYNNKIYSGSWDGKIGIFSEKKSKGKFISAHAGKVRVIQMQDSYLVSGGTDGKIKVWNLNNESCVSLLEGHSAPISTIKISPSGAILSGSEDRNIIRWPLVSSYSKSRSRSLSLIQQEKEKITRFKKDFVLKGKNVSQTKVVVTINGKRCHVDSNLNVLEACRKSGANVQSLCYHPSLHPLATCKFCVVEIEGIGHSFKKCCSCATPIREGMNIRTDTDLTKESLRKSLLNLTSKIESRNMNLMSEKMGNSNELTDFLQSSNQCFIDNSTQAVTLDLSKCIDCGRCEQVCSRIQGISVFSLEETEGPHQSTLKVNGKSLSDSDCIYCGLCTYYCPSDALSEFDETHIFEQFLTQKNDYHLVVGIDPSLFTTISELYGKELGAITPGQIVKSLRILGFHTIFSLQFSSDIYAIELSTELMKRLNDTQAILPILTSNCVSSVYMIEKLYPSLIPHLSTTKSPNQIFGSVVKSYFAQKLEKSPENIRCVTITPCIANKYQNKLKNIQSENISDVDLSITVREFGKILQNHSIDLRKLEEDSFDPPFSITSSAGCSFSVAGGVLQSTLRCLYESQTRKEFPKLEMNEVFGIPNMTEGTLMMEGRRIKVAVIDGSSSIRTFLNKVQSGNHDFDFVEIMACPGGCIGGGGQPKSKMNILPKRIVCSNQITSKFSIQNPNDNSDVQTLYTDFFKSPSIHISYEYLHTQNFHPIHYSSLKTKKTPQTKRRQINENIPQKNGLLVLYGSQTGDAETVAFRIGEECSFKAKSRVLEMDSFNFASLQHEKTIIFVTSTFWNGSFPENATSFWNHLKSLSPNSLNKLKFAVFGVGDSFYPHFNIAGKLLFKKLSELSQKSLLPLGEGDYRSPNGYLSALIPWIEDLKKVLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7X5</accession>
    <name>A0A9Q0L7X5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000135">
        <property type="protein sequence ID" value="KAJ5067065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7X5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="118" mass="14309" checksum="3859378D79B5AA20" modified="2023-09-13" version="1">MKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNGIQITQEIIEELETGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L839</accession>
    <name>A0A9Q0L839_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiosis 1 arrest protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L839"/>
    <dbReference type="OMA" id="CICHLKE"/>
    <dbReference type="OrthoDB" id="6433824at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051308">
        <property type="term" value="P:male meiosis chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007127">
        <property type="term" value="P:meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033587">
        <property type="entry name" value="M1AP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28642">
        <property type="entry name" value="MEIOSIS 1 ARREST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28642:SF1">
        <property type="entry name" value="MEIOSIS 1 ARREST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="529" mass="62573" checksum="263C51292E60422C" modified="2023-09-13" version="1">MNKENIQEIKINLILILENQNQKKQMFINFWIQNLIKSLKKFIILTISSKTKKSIKIQINLIKSKNQNKLIQFESEINLFLIEKLNNLFSLMKEQEFQMISKEEMTKNEIILKTLMEIEKNCSKNSNYQTYIKFFTSSKFFEEKEEMEKLMEKLLEKNIFFSYYLIYENENEIQNEIQNEIQNLSLFNDKKIGEIISSFPNCQFQIIQNFPSFFQEIFSQFSQEINLQNSIKIEIKFPKKLEMEKMKCLKQKELIKNPKITSTKTCICHLKEVLEKNPNDTNLYCSQSHKKLNKNEYFHSFQFGNHSKKQEIHETFGIVNNSSIQKENPKIIFKMENLVEIQGINQSLLFGVPFILTPDSDFISDVNEMENQFRDFYFLCAKLNEKKCGLLISKKIQIDSNKKIKKFFILISDSNSTCLFGKKIATSENIIGFQNVIDNDFLIEDSQTKNSKKIEECLDSFTKLEVYNPLLFSSETNILIEDSLREISNPNQNQNQNQNQNQNQNQNQNQIENENQNQNQIQIQKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8C5</accession>
    <name>A0A9Q0L8C5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_12758</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="JAPDFW010000123">
        <property type="protein sequence ID" value="KAJ5067951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8C5"/>
    <dbReference type="OMA" id="FPLICNT"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="156"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5067951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="309" mass="36693" checksum="C45AF36195C5F1F3" modified="2023-09-13" version="1">MNLIEKDHAIIFSIIILLSYIFIGFLFGFFFFSLFSKNQQKKRPNEKTTWDLSKEGMISAFFAQFSSFIVSLIGFNILIKKIDISENFFEMIGFSKINLLIFIPFLLTVILFLGPISFKYYDFRIFCEEKSITFSFSNFLLWIKEDPFCYLPKTKWKLIKNCVFAPLSEEFTFRSFLIVVFFLAKFNLNFCIFYSSLIFSLAHISFFLQNIFFKKVPIIPSIFELFFQMGYTFLFGIYTSYLFIKTHFLVPLFLIHSFCNFLGFPPLHRLFKHKNRFQIIIYAIFGCSLFAFLLPLLTSSKLYSNNFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8C9</accession>
    <name>A0A9Q0L8C9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000119">
        <property type="protein sequence ID" value="KAJ5068212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8C9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="264"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="318"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="600" mass="69980" checksum="FEFBAC90FD933627" modified="2023-09-13" version="1">MNDCLFFGENKYTIHIKNEPNEIIKPTQFKFENENENENENENEKQIKQISSGNISTFFLFKNGKAIEYLHENPQKIQIEENIQKVTVGALNQAILTKEGNVFAKGRYINSKNPKEFINISSLIKDINDRIIQDIVSGYNSIYLLTSNQNAYGIGPNDFGQLGFNSYVNHETEKPILMMKNVSKIFSGNNSLSVFLLNSNQKLFGCGNNECGQLGLGESRKERIIQELTKIQNIPKGKIIDIQIGWTHSIMLIENENQNENPKRKLYSCGDSLSNGLGKEYREDTYEFTEIKSSLFENDNILEISVGDRHTLILTSNSKLIGFGYNLYGELGTGNTEKDQSIPIQIELPKLRFNEDISNYHVSCGSQKSFLYYSHPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNENEKLEEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINLNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEEIEITQEIIDEIQIGIDYFQLNQTYPNLFDLLINKFNNQNSNQKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8E4</accession>
    <name>A0A9Q0L8E4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter mch1-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5067981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8E4"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="129" mass="14159" checksum="A4654043787F9A71" modified="2023-09-13" version="1">MQTRNKFGWFQVLQIISAIIISLLCGAPNAFDKISSKIQNTEHYNDGFIQVLTSLEMLGLYFTIPAGFLHDKFGAKIASLIGGVSSITFFFTLWLVFGLGTGFICSLGTALKVSPLKYLGINMSLVELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8I5</accession>
    <name>A0A9Q0L8I5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small gtp binding protein rab8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5067013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8I5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="309"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="427" mass="51098" checksum="5284F8020E62BC1E" modified="2023-09-13" version="1">MINSKNVGKKRKAHFKMAIIGEENVGRKTIILRVCETKEVDNRFEELGNQFQFKQMKGPIIDFTWEIWKGLPEHSNNFRGANGIMIVYDITNEKSLTRVNSLYHKLRDWENENAEFVLIGNKCDLQKKRKISSERGKALADELKIPFYETSAKKDINLKEAFDNLIMNCFERSLPDKFIKNFENFSLSDDLRHLLERKEFCDFEIECQDDRNPFKKITIPVHKLIIQTRLKINENQLKNQFYSILYQNPKKKVDVLLRWIYYGRVLNSNLLIFEEWKNRLSNISTANFKKGKKYLVEDLKNLMTQEENKDFQIISNDQIITVHKIILIARSELFRGMFMYVTEDESNQVHEYSHKQTETMKSLIHFFYTDELPQTNNQIIYQELKELLLFNFFLFIFKFIMIKENKLIVELFHLIFLNNHELDLMNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8J7</accession>
    <name>A0A9Q0L8J7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8J7"/>
    <dbReference type="OMA" id="RYGEYIN"/>
    <dbReference type="OrthoDB" id="5953547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="176" mass="20342" checksum="BB7234409B0A4380" modified="2023-09-13" version="1">MKQEMEFQKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHSKVDGKGKTLVIIKTKDNFIFGGFTRVGFKHSRYGEYINDSNAFIFSLRNDKGDRKPAKFTIKQPQYAIYSTSSYGPTFGSSDFELRSDLQAGWSNFGYSYNLPNGITYQSNEAQSYLAGSYNSWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8U5</accession>
    <name>A0A9Q0L8U5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nice-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02733</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8U5"/>
    <dbReference type="OMA" id="RIPRKIM"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010876">
        <property type="entry name" value="C1orf43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21425:SF2">
        <property type="entry name" value="PROTEIN C1ORF43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07406">
        <property type="entry name" value="NICE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5067545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="189" mass="22768" checksum="ED3B03C0ED5BA850" modified="2023-09-13" version="1">MSDVNQETIEQSLVHITVFTSILGLLFMVVVFLIQYRYRKHRRLLNQIPRARMRNTKKDIPETALRHIYSGFQEASRIHDQILQFAQTQQKPGWHKSEWNYKRVVADSPFILEQLAKRKDPSLARLDSQSVRAYMQFLLKKEPELNPKLCKYFVEMYERARFSEDEFTERDFINFLQNFAILKKFFEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8Z7</accession>
    <name>A0A9Q0L8Z7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synembryn</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8Z7"/>
    <dbReference type="OrthoDB" id="10688674at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="554" mass="65207" checksum="B6263C618AAAADE0" modified="2023-09-13" version="1">METLLNQLQKSQNQQEQVELLTKFNTENQNQREFCKNSKDEEIKLKLIQFSKNQLLNKNNTLKNELKTQYLILIRILLREKTISSDILTSDFVSFLSQTTFPSQFNLNQLENKLENQVEQKDQEQKTTQKKQEKESKDLLREESLKCLINTLFQNETAQQFFKSINGLDLLLNSLQNSIENDSFLSFVTRCLFHLSLNKELLEDLRKKKYRDISCFIIEKYLQSTKGPDPDKFEIIHNLLLLIYNDINDEHQDYLDEKEKDLKSKKSQLIMKIYTQQIGLHLINILLFPNPKQVQMENYLSDDFNSKMNLNENSNENLNENLKENSNENENEKENQNQNQNQNQNENENQNENENEQDIDDDLIFDPPNLEDENSVIYRIKLKAITVLLFIPEGYVSHLTKTTSEKTQESLLIKLLHILQIQLDQSFVFQDGEFESTRKAPELLVPILQVLSIVIKENTIAQKYFTNVIYYNEEKCSKDPKKLNIKERLKDLTTSHNFALNHVVNTFFFNLCHENVKEFISFIGFERAIGFLVNRGLFKLDGIDNDDIDNDNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9B8</accession>
    <name>A0A9Q0L9B8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_02665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9B8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="181" mass="21519" checksum="829DD7C80863A969" modified="2023-09-13" version="1">MLHFIEIFISSFVSMQNSSNKSKEDQNKIINEQVMKFSQNILKLSDIIQDFSYVYSCSSTFTSQVLIKNVSDIYYKLDKVINDPLKLKSIKFYEKITNHQKSKLKSFITKVNKIILLKGWKRLILDLKDNKDENQKLKKVLIKKLSKYKGTKTTRNQINKYFPQKILLKHIYEAYQYCKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9J0</accession>
    <name>A0A9Q0L9J0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000113">
        <property type="protein sequence ID" value="KAJ5068827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9J0"/>
    <dbReference type="OrthoDB" id="8191755at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="459"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="684"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="756" mass="89374" checksum="569E4F5C8FAE6DA6" modified="2023-09-13" version="1">MSNPSKSHSCLVSSPRRSFEPPKQKVDWCSLYKQIEEGPYGVISHLSKKLNIPYQTLYSRYQGYKIGNPMGSTSNEKRKIANQKRCCRLTFEQENQITLANQMFIGKNQKPLSIHWPYRFMKRNNFVFRKNKLVNKWTSHISPKQTAQQFWQECKTKRIINHESSKFKIDHSFIFNVDETNVQFFTTSNSIGNKGKNGKSICVHNTKQTITMIAAIAADGTKIIPTFIIKAKSGIRLIPQLQKKFSKCYFLNSNSGWSNTFIMIKWLEEVLIPHIKDKMKQENNCDIPDSILVLDRFAAHRDKDFLKVCEKNKIRIIHVPSHMTGLLQPLDKSVFGPFKINYRSNILPKMNEMGILRREDVIENALKSWNNLNSTKIASSFRKTGVICDSIHTIDEKAVEEFEEMIGFFEKKTHQKRRSKRNINDEEEEEKKKEKKENEKNNKKNSNKKLKTKSQEPKRRKTQKKKDSISKNNTQSPDLVKDKESKYQIKREDITQQLKQIKNEEKVTKSFANLHGWRQRIMNPNSNENWLSEFDIDQFLILEKSNFKREDIIIVPSQQPKDVIDVLQKIQLYPTVQWIILPVITGLHWVIFVVNFEMKRVEYFNSFEGYFSMLKLGEKIAKLLIFSFVEVFEGQKSIQKNRDDCGSFICFFIRCRIFREWTLEKMRKKVIAKDGSEFRKEIYSIFHENEKSEQKNKISEIKEELNNQKKKIDKIISASTHLKSRKEKKKKMDNIRLLIDTYRMIYRKLLYWKNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9J7</accession>
    <name>A0A9Q0L9J7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Early endosome antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9J7"/>
    <dbReference type="OMA" id="HDEMENA"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="396"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="542" mass="64322" checksum="4E0C54F935E7F959" modified="2023-09-13" version="1">MSKNFEKFQKNQEKKNKEETNLNEEKENHKENENENEKEKEKKVSNMKTKIQNFKEKNKQLEEKEIALKDRLESVLKDCKILRKQNSESQEENEKLNEEIDNLKIQLENETHYFEQIQKKLDKNASQMKELKKQLTILEQYQHNLNISYSDYDRLKKENEKKNAIIDTLKCNIEEQNEELGKVIQNKETEIIQKQEEIQQLNTQLQSSKKELFSLQTTFAQTTKELEKIFSQLETASKVIENLTKSNDIFKKKIVHLEKQLHLINIVKSKMNQELIEKENISKQLRERINSLEGFLKNKSHQNTILLEKNDHLEKVIISLKKIIEQKDQEIEEYNTKIMFLSKNSNQNPIKNSNQNSIKNPNQNPIKNPIKNPNQNPIKNQKISPNFLKRKSPLNAEEFQEIIKNKNQKINLLTDSNSKLNQDLQKKDQNIRSINEKLDKIKNENSKFTNQINQLKEKNRDLIQRKQIQTQNQKEIISKLTEKLKLIENGILKENQNLINSELNEIRILLNRITPKTPTKQETNINPNQNQNPNQNQNIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9U4</accession>
    <name>A0A9Q0L9U4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107">
        <property type="entry name" value="SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107:SF33">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5068746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1315" mass="155420" checksum="0360F776DD1D539C" modified="2023-09-13" version="1">MTRSNQINFSYQAKEPFKVINELPLDQESEKDTLDKKSLLNFANPKSLFVSNQIDYLERYFPKLLIPHEILQKMILESQKVEENLKFLRGNNVVTISTKKSNYAFFVQSSFSNVVDFGILEKNHFVKIQKLKFSHTIYSLSTLSTPSGKYFVVVRSLTSIGIIELIETTYKSMAQWIKTFFFPSFISDVSLNPFYPEIAVLTENNDIYIWKSGDSMLRFHLPEIKKKEEEKYMKKKIQTKGRQKGKTKNLKKRRHFYESNLSRIKCLIYGSHPRIFIISNGNYVYKLDLRKSNLDPNQDFELPSNLTFFAENRSFNPEQMTIFIDFEERFNLNFLFVSAMTRHPIDKFIFTIVTSLHVILCDERNPNEVLLIWDHYFQLPDIPKFVTILNLDSMFTERNESEDESESEDESESEYQSENENNQSENNENNENNENNEYQSENNENNENNENNEYQSENNENNEYQSENNQSENNENNEYQSENENENNQSENNENNQNENNEYQSENNENNENNENNENNENNENNEYQSENNQSENNENNEYQSENENENNQSENNENNENNEYQSENNENNQSENNENNQNENNQSENNENNENNQNENNQSENNENNENNEYQSENNENNENNENNEYQSENENNENNENNENNENNENNENNENNQSENNENNENNENNENNENNENNENNENDIDIDFENENNENNENNENDIDIDFENENNENDENNENESDIYIDVDSENTSTSTSNSDIDSEDSSENSNSNSKSSENSNSKSKSSESESESERNIPNYKYLQFNKDIFQNKRTKFKAKPEENIFSSIFFSNSNQIFQQDSDMEESNEESNKESKDENEDENEDEDEEFHLNNPVSYNLIIAYTSNSKEIICFPYCDNLYDKMKMFKLKAQYYKSYPIAVDIPFKIPCFNSNLTKPKDPYAISLSGFSIFHYIKNKFIIILTSSIGDALSQVGKIRISRNWDYKSAKRKLKIKEKDKTLSEIKPFQIQPENKNILPYRKISLKGVLENFKFWKPTENEEFLENSLKIVNDNQNFQHTMAEFAFFLEKSENVAYKSTPYLKKILNQRQIPRFSVYDWKSNFNWQKSYREEENKREIEEMINLTKTIIEPPEIKDYSSESDWKQENDQESEKVLDDLLFSWELQDKSKSKLKLQLKDESKKESQKESQKESQEESDQKLEQELQEEFGQESQESQQESQQESQQESQQESQQKHVHFSQPLNSNIQQNTQQNIRQTSLSQQILPPSFPLTIFSESLDFQAREEQQNFNQFSQSQTQSQTLSQTQSQTQSQTQSQTLSQTKKKRKTRKKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9X0</accession>
    <name>A0A9Q0L9X0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9X0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="590" mass="69101" checksum="923C2FCA63A6392A" modified="2023-09-13" version="1">MNEILFFGQNQYPKFIKNKSNEIKKPIQFKFEKQNENEKQIKQIASSYYSTIFLFENGKAIEYLNENDSNENSEKIQIEENIQKVSVGYQNEAILTIEGNVFAKGYDINSKNPNEFINISSLIEDTNDRIIQDIVSGYQTIYLLTSNQNTYGIGYNFDGQLGFDSVTLKRTEKPILMMKNVSKIFSGNCSNHIFLLNSNQELFGCGNNEDSQIGLGESRKQEFKIQKLIKIQNIPKGKIIDIQSSVSFSIMLIENENPKRKLYSCGNYKFNGLGKYEHSYEFTEIKSSLFENDDDILDFSVGNAHTLVLTSNSKLIVFGYNSDGQLGTGNTKNQYSPIQIELPKLRFNENISNYHVYCEDNRSFLYYSPSFSNLEEDLIRLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQNQIEIEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYYEIKEIINLNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVINDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIQITKEIIEEIEIGIDYFQLNQTNPNLFDLLIKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LA05</accession>
    <name>A0A9Q0LA05_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LA05"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="491"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="607" mass="70818" checksum="955C582C4D9C8BE4" modified="2023-09-13" version="1">MNDCLFFGRNQNPKLIKNEKDEITKPIQFKFENENENENENEKQIKQISSSYFSTIFLFENGKAIEYLKDLNQNPEKIQIENIQKVTAAFVKGVILTKEGNVFAKGINIDLQNANNTKEFINISSLIEDTNDRIIQDIVSGWNSTYLLTSNQNAYGIGSNRFGQLGFDSETLKKTEKPILMMKNVSKIFSGISSNSVFLLNSNQELFGCGYNESGQIGLGKSRKYEAYIQKLTKIQNIPKGKIIDIKSSDHSIMLIENEDENEDENENENPKRKLYSCGSRHYNGLGKNKDTYEFTEIKSSLLKNDDIIDISVGNDHSLILTSKSKLIVFGDNYYGQLGTGNLKYQLIPIQIKLPKLRFNENISNYHVYCGYLNSFLYCSPPFSNLEEDLIKLFRRKEFCDISFKTKNGEIIEVHKLILKYRLNQNQNEIEKLKEIISKKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKIEEIMKRIYLNENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKNGIQITKEIIQEIKRGIDYFQLNQTNPNLFDLLINKFKNQNQKKRKLKFECF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAF9</accession>
    <name>A0A9Q0LAF9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000122">
        <property type="protein sequence ID" value="KAJ5067988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAF9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="69" mass="8264" checksum="2E605B69D3352E84" modified="2023-09-13" version="1">MFQLNVQDSSNQVHDYSGKSFETIQQLIHFLYHDEIEENELNSRNFEELQDAKDYYQLNPNSIIDLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAG5</accession>
    <name>A0A9Q0LAG5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAG5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040227350" evidence="2">
        <location>
            <begin position="18"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="319" mass="37126" checksum="A405FB6F2A80A323" modified="2023-09-13" version="1">MNFYIIFILISFFYLESFQTPKLHLPVFVWSNKEFYKGINQRISTPYSQESILKYISIISQKTNEQKIEDLDIHNYISIPENTNLDVVIFFILPEMRSDELLPLTQACEGKNLLSYIAEEIMTKSKSSLLFSQMHQENPDSFQQELDKLLIPGEALFLKYLPQIDTFVPQDNQFTIEKKITNEKLSSVLEEFITNSNSNTKFILVDIARLPQQEQPLCRGTNLIDSFLKFLNQPENQQISYIQVFTANKPSLINENIKFTFDQNENSENPSLLSFDDSFSQFKIQNQVNDAWNNLLAIIFLMTALFVVAFYILIADLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAX6</accession>
    <name>A0A9Q0LAX6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_02102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAX6"/>
    <dbReference type="OMA" id="YAEGIIC"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5069532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="417" mass="47740" checksum="4AA9FFC98E43DC8E" modified="2023-09-13" version="1">MTKKERRTYYQSKKKEREQNEESKISQKQKKKQTKQKNKLEINQNKNVRWSSTDLFSITSHLRKYHSQNSISMGISFGEQKIHSSVIKLGLKFSSGIVKGTTNRSICLLNVFRDVINDMKIENIFRDEAITQLNKQIAFLEKYRPFSEPMYNVIKIVKNSILKIDPNLTYLEAKKHICETVIDNFIQSKIIDAENEISELGTQKIKNGDVILTYAKSRVIEMILKRAHKNNIKFRVLVVDSRPLNEGRELLRTLDKKGISCTYCYLNALSYMMKEVTKVYLGAATLLSNGAIVSRIGTSIVAMMARQFNIPVIICAPTFKFSEKKSTQVTQISSSAVMIQKSVLSINSCFLPNNNSTDGFHYPVPTYRDDQNLQIFSLLYDVTPIDYVSIVVTEFGLLPPTSVPVIIREFKKELTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAZ2</accession>
    <name>A0A9Q0LAZ2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rim-binding protein isoform f</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAZ2"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042846">
        <property type="entry name" value="BTBD19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46965">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46965:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="86"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="841" mass="99727" checksum="53CFC73BBDC6C76C" modified="2023-09-13" version="1">MENKKHKKSKNKTHKKKNKSKQKEKEKEKEKENETTETEEIEKENEEIEKENEKEEIEKENEEKEKPTKMLIKNYSNLLHSPNNFADFKLIVGSNSVEIPCHKAILSFQCPFFKKILRKQETTSYSFDDFNPNIMMLVLDFIYTSQINLQMENVIQVYLLSQKILLDLLTQQSHNYILQNLNAELVLQIFQNQNQNLLQTFKEQIDNFIRDHFKELLRFKEFSDLPFNDLIDIAQIAFQNHYNLKTFRLLDFFLNLIKLFKQQDFSLKQKIDNKNLIENFWEKYGKQFEIINIKDKYKKKRDRFINKLKRRQKSIDSEKQKANFTQNENQIQNENENENENQNQNQSENENENENHSHKSKNSKRRNKNGNQNENHFKNSEIVEENNEKKKLGKHKSKRKSKKDQNQDENQNQSEDENENKNESENENQDEDKNEEEKKHKKLGKHKSKRKSKKDQNENENENEKRNHSHKSKNSKRRNKNEARKNRIKYPNIYQSAKILNSKTNESKKQTNNIPKKLHKTQILVHKKSEKKHSNHESERKLLNPQDNQNSTGNKHKSKHRKKKENKKLKRVKSHQITKSKSNQFSELYNENENENENDNENENENENDNEIGNRGLSPNPQFENIKVAILTLDHEEKQRYDLIKTLVFEGFHPNNIDDIFLENQEPIDLVDYHVVLVYSIGGSELARKMGDFLYEISIMGIPILIMFGIDVKDAIEGKFLEIIPYVPGEQIIGENQKLGEIRQPNHPIMKGINEIISGEISYHSDIKSKDENQVICYWNDNIPLVIVGNIPKKDESGKHSQIMVLNLFPPSSDYLQFYWSVSTDVGKLIANSLFYLVNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB33</accession>
    <name>A0A9Q0LB33_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neurofibromin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NIHRYVT"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1580"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1617"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="689"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1372"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1456"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1525"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="5">
        <location>
            <begin position="1677"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1401"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1460"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1479"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1549"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1984" mass="220091" checksum="925BAEFCD182B39A" modified="2023-09-13" version="1">MIDKDQNKKYDVYFTTKQMISLSKFILVILLIGFISGAGEVISYTGLTDWHQPRSYSYVNGWFGTNELYTCGGTYSPDTNPTVATGAASYQFFASDTASSYLRGYSFKFPDAASLQIYGVAGWIGRNGKLNQGHTQICSGWWIFQTCHDYYYNPYFTYLLEDLCQLATGNANVDYTLTPSPDNWAIVGDSSAVQRNKSFGGLNDLAGATWNYQSFDNGSFGINMENVMQYTGTTGDSPAMSITAYWDCAQIQVNYTYSATVTGYANTEGRGGSPIQVNLTGNVVANGQYNNLNIQWKCKYQDVISDASVVNPPDSITCILPDISPLNNGTLYVTWDESKGWMSGTPDITILDSCIENSSCGNGYCDLSSGNCICDQAYMGYDCSVLKCPNGTYGTCNDNGWCDDSGSVGFCWCNNSYSGQYCDVNLCERDHNNCNDDAPNSNNYCSYQGTEGGCVCDPTQGWTGPNCTVRLCDGVNCNNGTCVIYTGVCSCDVGYFGDNCEYKYCNDTVDVCNGNGDCINQTGGCSCYQGWTGDHCNISWCEGIDCGEHGYCVQLEGHCECDKYWTGDLCNVSVSSNKWADRMGRKLNMSGAAFLAFFSTCMAALGIILVAAGFIFWKKRHDRDKWAHILALPIFTVESLFGENFYISPQDRKKLKRPNIQSAYFDLQQLLIENMILVDCLCIASETKVASYLGRSLLYVFEANGESPQLLKYFITKEVSTCDDGDLLFRGYSMASKLWGAYCHLAYGINYIHGSLSETVHELMVSQDMANIELDPNRIDTDSTTTVNKYNLMAAVQAIFSSILKNADNFPPQFRFVLSHLKEEVLHKFPDRVSQSLGGMVVLRYFSPAITASDEFGLLKEPPSDELLRTLILVAKVLQNLANGTLFGAKEEYMNTVNDFISTNEEKMINYLDSISTPNDESRDELSFESSPLPKDVLEISCANIHRYVTLNKTEIVETMQTEIQDEQRFNDLLSQLEEILDRLGDPINVQADEDHSLFKNKERIKMISLSKFILVILLIGFISGAGEVISYTGLTDLHQPRSYSYVDGWFGTDELYTCGGTYSPDTNPTVATGASSNEFLNNEVATSYLRGYSFKFPDTNSLQIHGVAGWIKRNGKLNQGHTQTCSGWWIFRRCTDYYYNPYFTDLLEDLCQLATGNGNVDYTLTPSPDNWAISGSSSSVQRNKSFGGLNDLAGATWNYQSFDNGSFGINMKNVMTHSGTTGDDPPLSIMAYWDCAQIQVNYTYSATVTGYGNTEGRGGSPIQVNLTGNVVANGQYNNLTIHWKCKYQDVISDASFVNPPNSITCTLPDISPLNNGTLYVTWDESKGWMSGTPDITILAGCTNDSECGHGTCNTTSSSCICEQAYMGYDCSVLKCPNGIYQTCNNNGWCDDSGSVGFCWCNDSYSGQYCDVNLCERDHDNCNDDAPNSNNYCSYQGTEGGCICDPTQGWTGPNCTVRLCDGINCNNGTCVVYTGLCSCNVGYFGSNCEFKYCNDSVDVCNGNGDCINQTGGCSCYQGWTGDHCNISWCEGIDCGEHGYCDQMEGHCICYDHWTGDLCDTEVTSDKWADKMGDKLNMSGAAFLAFFSTCMAALGIILVAAAFIFWKKRHDRDKWAHILALPIFTVESLFGENFYISPQDRKKLKRPNIQSAYFDLQQLLIENMILVDCLCIASETKVASYLGRSLLYIFEANGESPQLLKYFITKEVSTCDDGDLLFRGYSMASKLWGAYCHLAYGINYIHGSLSETVHELMVSQDMANIELDPNRIDTDSTTTVNKYNLMAAVQAIFSSIVKNADNFPPQFRFVLSHLKEEVLHKFPDRVSQSLGGMVVLRYFSPAITASDEFGLLKEPPSDELLRTLILVAKVLQNLANGTLFGAKEEYMNTVNDFISTNEEKMINYLDSISTPNDESRDELSFESSPLPKDVLEISCANIHRYVTLNKTEIVETMQTEIQDEQRFNDLLSQLEEILDRLGDPINVQADEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB66</accession>
    <name>A0A9Q0LB66_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribosomal protein S6 KINASE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_11508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000102">
        <property type="protein sequence ID" value="KAJ5069846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB66"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="241"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="509"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5069846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="70535" checksum="59D0DBFEC230F4A4" modified="2023-09-13" version="1">MDNSKIGKQKNVKHLDQKINKQSFILKKNKILKKKMKKEKENEKENENEKEKEKEQKQTVSNWNQTRASKSRSFWKSSRQKNIKHTGDLRKFRVIKINSYGKKQKRIMNLSRAGCSNLSGNKTRWFLEPKYIYNIQKIQSNHEGLVLTALHKIKFECQDQHQFERIIDAFNLLNLGKLLNPESQITESSKIPNNNFKKEKEEEENQNEQIETQKNQNEQSNTNINTNTNTNTKLELELDLFDLLNVIGEAKCGKVIQVQDKINQKIYAMKFLDKSCLIKNNEISNTILENDILSTINHPFIVKLHASFQNKTKLFFILDYVSGGELIYNIEKNSKQEKTQKAKESIARFYLAEILLALEHLHSNDITYRNLNPKNILLDSEGHIKLIDFSKSRKVNLVDDKKIQEEKTEIFYENEQYLAPEILQGEKEGKAVDLWSFGILFFEILTKTTPFYSSNQNEIKSKIIQSNIEFPSYIRKHSKSLIRGLLKKNPNERLGINGFEEIKSHPFFKGINFSRFLTTKTKPPIIPEIDVFQNEDYYPKLSSINVNEEIEKIHFPMLINENEKQNENENENENENDYFQNFSFISKSFEDSIQIVSQNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBB9</accession>
    <name>A0A9Q0LBB9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intein-containing cell division cycle 14 isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBB9"/>
    <dbReference type="OrthoDB" id="266663at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030908">
        <property type="term" value="P:protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="708"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="810"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="873"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="923"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5069936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="937" mass="111107" checksum="49087F8161FB9E3D" modified="2023-09-13" version="1">METVKFYEFLPNRLYFFGSQNLLDSSQSIDYYFTIETEFHYDPFLFDFGPFNLSQLTRFCRLLHSKLQDPKLKNKRIFFYSLSDSQKFTNSALLISSFMVIVMHKTPEEAFKPFENCDTFVGFRDASYDPPTFLLSIQDVLNGLYKAIQFNFYDWTTFSIEEYEYHEKVENGYLNWIIPEKLLAFGSPRDLPSKSCFFVDEEDNENEDNEDNGNYNETKNDQNLVNQENPIIPENQINQEINQEINKEINQEINQEINQEINQEINQEINQEINQEINQEINKEINQEINQEINQEIIKEINQEINQEINQDLNNKETSMNIDPSQPKIEYFDENDLNFQYWTSSQHLEYFKKHNITCIIRLNLPLYDPQIFTKNDISHYDLYFEDGSVPSWEIINSFLNIVEQEIETNNKIGTNPNELENSEQSKDKDQDKDQENRERVVAVHCFGIDTQVLMADFSSRKIQNIQPKDQVMGIDYSPKKVKTIIQGKGKLFEVKRAHQEKYIVSEKHILCLLLNKQTNRQIDIQFQNDDYWFFFRYFDSNHNLVTKRFPVFQKNIGIEQNVINFCWKNQTLFDSNFNYLGKNQKMEKLIIEEKDFLDVKRNFSRAFLEMEYYYKNNYAVDFGDRIEITVEKYLQKTKEWKNNHSGYSSFMNQNQCESNWNLNQKTNGKNLNLDLHDIEVSLYKKQGNFYGFELEEKDPRFLLKDYTVVHNCKAGLGRTGTLISIYLMKNYNFSVREAIGFLRLCRPGSVVGHQQQFLEKISDEVQELIKGGKQVQKKINKIVSSINNGYYQDYLYEQENVNENVNENLNENLNQNLDENLNENLNENLNENLNENVNQNQEIIKGDELIESQKTAQQMIIENLEESKRKQQTPDQTPTKTPDQTPNQTPTKTPNQTPDQPKNYKAILAHKRIELLQKKQQHHQNQNIKNQQENLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC59</accession>
    <name>A0A9Q0LC59_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_02241</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC59"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="6"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5069664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="277" mass="32428" checksum="A127D101C1C9ED79" modified="2023-09-13" version="1">MVLTSIIVCCIIGNFFGIFGASSFIFSYKILPEIRNRSRLFILTLSICNIICEISGLLPGYKNTHLCTAQCFLINWIFIACFCWIFMISLIYYLQICRNFDIENSPKFYWFSNLFVQLFSLLHGILAVTLGKPKSGASYWCFISDKNVEIFHYSTIWFFLISTLILYSLVVHKIRKDKDINYPKSFQIKMLTLATLYIITELSLFIKKMTQIFKKDYSPNEFVDAFEAFFTPLLGFWDFVFFVVGDKFVRALLIRKFKKKKSQDVIELNQGLISFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCA6</accession>
    <name>A0A9Q0LCA6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCA6"/>
    <dbReference type="OMA" id="KPSQDRW"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000001">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="139" mass="15845" checksum="42001E03E1BF721D" modified="2023-09-13" version="1">MLSAINQNLKSKTQKQTINSILRFIASKFQISIEGAKEFKEKVTDSDKPVIVDFYADWCGPCRMIAKPLDKFVDSHEGKVILAKVNVDRNDELAFQYEVSGIPTVYGFYKGKVVDRFVGLPEEDFLKKFVEKMVKTGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCA7</accession>
    <name>A0A9Q0LCA7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_11785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCA7"/>
    <dbReference type="OMA" id="YLVMESR"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5069300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="311" mass="35458" checksum="703F57989CE65D9A" modified="2023-09-13" version="1">MELDFDVDSIIERLVAMKDSKIKDPGLTEKEIRTLCEKAREIFLSQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFMGDYVDRGLNGLESVCLLLAYKIKYPENFFMLRGNHESALINRLYGFFEECKKRYRVKLWKIFSECFNCLPLAAIIDDKIFCVHGGLSPHLTSIEQIQRITRPTEIPDEGLLCDLLWSDPDPNIQGFGPNHDRGVSCVFGADAVAQFLKENDFDLICRAHQVVEKGYDFFAQRRLVTIFSAPNYCGEFDNAGALMSVDESLMCSFQILKPTTSKAISQNPSNKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDS9</accession>
    <name>A0A9Q0LDS9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDS9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="253" mass="29549" checksum="A5A7C804E17A2ACC" modified="2023-09-13" version="1">MELIKELSEQSELTKYKLSDFVKENLTKDETKPFTDSKEFFDAVTSFLVLSFISFEEINFPVTLFEKNSQPKNFPAHVQWIEHTRKLKEKMKEIIFKKVELMPNKPIVARYKDKIKLTDKEFLLLSCLVLSSIGFSIPNAMRFYSLEGLSTMGLFGDMTPFELINFVSPTRGHMKDRMFKNGIESYGYMRMEPQFVAALFDQDLSEEQMLSLQGTNLGAVFEERKKEKEDEKKNGEEKIELAKNELEKIDQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE70</accession>
    <name>A0A9Q0LE70_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">U6 snRNA-associated sm-like protein lsm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_02190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE70"/>
    <dbReference type="OMA" id="TICVKFQ"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5069620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="97" mass="11095" checksum="66AF59842431EBF7" modified="2023-09-13" version="1">MSRRNDFKSIDLKRYFGKKIEIKFLDGRQIVGTLTGFDKVFNIVLEEASEYSQDPSNFFQVTDKLVYLGLVVCKSSSICVIFPSEGTEEIANPFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEF8</accession>
    <name>A0A9Q0LEF8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEF8"/>
    <dbReference type="OMA" id="REKEXEK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="182" mass="22303" checksum="2F1B094C155CC51C" modified="2023-09-13" version="1">MEENQEIIENELKEDDKKEDDKKKDEDNKQEESKQEEPKQQNQQKQNQQKQNQKQNQNQNQKQNQPQKQNQQQKQKQKQKQQNQKGKGKRKGRNQDEDFDKIMEENQEIIENELKENDKKEDDKQEDDKKEESKQEEPKQQNQQKQNQQKQNQKTKSKSKTKSKSKTTTKRKRKRKRKKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LER4</accession>
    <name>A0A9Q0LER4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein BOP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_10169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000087">
        <property type="protein sequence ID" value="KAJ5071537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LER4"/>
    <dbReference type="OMA" id="MRPAKGE"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000576">
        <property type="entry name" value="Ribosome biogenesis protein ERB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="71"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5071537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="809" mass="94769" checksum="E97A92D7D0905E48" modified="2023-09-13" version="1">MIFEEIENESTESDSDFLPTESEELESEEERNEEEEREAFYEHFLSDSESESEGENEELRNTIGDVPVEWYKEYSHIGYNLTGEKILKRDVIKAQKKDNLDDFLAKFENPDYWRTIQNKLTGEDHVLTDEELATAFRIQSGKYPDADYDPYAPHVDFFDYPDGKLHPLTNKPISKRGFVPSKWEAKKIIKIVKRLRKQKYSKRRTRRVVRDFLLWSNQEKMPKKFAEKKKLAEKRKSKGENIPAPKPHLPGHEESYNPPPEYLPNQREIEAWESIENYDEKPRNFLPQNFDRIIDIPAYSRFLNERFDRCLDLYLCTRAKKRKQKLTKRKIIPKLPDLEDLKPFPTHEMITYKGHINKVRSISVDPTGNWLVSGSDDKSIKIWEVFTGKCFKTWEFSEIVYSVAWNPNPETPIIAAAVGKYVLIINPGDSILSVKQVNNLMKKFPLVIEHENFDENQLEDENLNENLNENENLNENDILDRNQKIKQKLSQLNQLDNQNQKNPKKSSTHKKRHNAIWKSPKEFLNEIRSKKLIFQQKKLNPNNSNTDQLIEKLQIELEETEAHDNHELYYTKEDYESQEFKFTTKGIVAIIKCTNIVKSLTWHNKGDYLASVSPNGGREAVLIHRVSKNMTQNPFGKSKGVVQCVKFHPKKPLFFVATQRHVRIYNLLRGKMTLKLMPGVQWISSIDIHPGGDNLIVSSYDKKLCWFDIDLSTKPYKIMRYHSLAIRKVAFHNRFPLFCSSSDDKTTQVFYGKVFNDLLQNPLIVPVKILHGHEYPNEKLELGVLDCVFHPIQPWLFTSGADKTIRLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGI1</accession>
    <name>A0A9Q0LGI1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGI1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040477619" evidence="2">
        <location>
            <begin position="23"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="184" mass="20938" checksum="11186D82D7B57D9A" modified="2023-09-13" version="1">MKILLFLFLFHLFLNSYQDCASDFDCRTRKYPVCENSNCVECRNSSDCDFDSYCNTDSYECQKYKDDNKFKKFCQSDDCADNNNAEVCGVCNGGYQWTGSCIEFKCYPCQVNGPDSEIMQSHKDVARCYPKSTSGSGGYLGPYQATEGRPRDLKQDSPTLGLMMLGFAFGIMTILQCIIFFKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGV0</accession>
    <name>A0A9Q0LGV0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B-zip transcription factor (Eurofung)-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGV0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="174" mass="20925" checksum="0671F304C3E253FE" modified="2023-09-13" version="1">MFYIPEGLFNFENGDFKEHFLKTFPGIKGLENLSGFEQQEESEPENPIIEINRKIKDRQKTLENEITMEEPTQRKRKSQEETKKSNYRTRQKERLVKLEERIRVLKEQRSDYRLKEACLQTEIQTLNKNLEYFQNFISLAMSLAYRSTSDDNEPQNPPQSNSFEFFEHLERSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHE5</accession>
    <name>A0A9Q0LHE5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_08809</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHE5"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5073401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="658" mass="77281" checksum="C14D38EEA66620BF" modified="2023-09-13" version="1">MDDYQLLKKIGEGSYGVVYLVRSKKTGGMSVIKKVSLKDMSEKERKKVHKEARILQMLHHPNIVSYYDSFEDPETGSFCLVMEYVSGGDLRMKIKEKQDQGEYFTEEEIYTILIQLISGLKEIQDHKIIHRDLKSANIFISKKGLLKIGDFGISRILSNTYEKAKTLIGTPYYISPEILENKPYSFQSDIWSLGVVIYEICHLKRPFESDNIYGLVLKILNSEPPSLPSFYAKDLQDFILSFLQKDPQKRPTITQAYESPFIQSLSQKYTSSIMFKINLSNAFNKNPDSHHNPKSNQRSHKNVFKTKSNRKKFHQTLSPVHVVKMNDLQNSKPISQFHSENHKLRNQRALRPIDINSNYPNYPNYSNQSKNTNYQNLPKFQNKFQNKFQSEMKPKITTNHYLINQGVEPRLSIINDSTENFHNMTNSQSELSIPRSHLSPYYNQQHNYNSPILQEETRLSSSISFLKPIQIYQDQNPSPYINSYQKESPENKEKEQKLQIQQIQVKDRERLFRINSYLEKKEKMVGKKQKNHLPKILFSEQKDEQMEKFSGEKKSIKNFPSEILDQTSLSPDESIHNKFDKIRYFIESQIGSDLFSQVHQKIFDYQKYQNSENFSEQNEFLSEISKLMDGKFDWIPLIERLVRCEIFANQQMNMDIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHR2</accession>
    <name>A0A9Q0LHR2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHR2"/>
    <dbReference type="OMA" id="WANEVIG"/>
    <dbReference type="OrthoDB" id="2124221at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="2">
        <location>
            <begin position="906"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1136" mass="131023" checksum="B1E6C19912DA2BE8" modified="2023-09-13" version="1">MFLNNISAATPITQRPDTGVLLNFPHEIRRNLISLVNSILVDKQNSIRILTSTFHIKWANEVIGQAFALPIEEYRSIEQSIEIYHRWLLGVDIPAPFDEELNFFYRDIFAHMSLIFQPRKVVTQEILTKHIQLCKNVINIYQEVALERSQNFSTETWEYLLNTLIGISDSLVSNESNLTNELFSYLIRLLYDVWLRSSTKNLEMWERLRKSSISWRLKTETITQWIATIFGLTNKVINILYGPTEGNNLLVIDLPKIKSIGVDPKPIEISHEQIIFSWNRFLQMIGNPNEITMQSLFWDSMMGIQKCIKALLDVGSKYDPKTTSEVIVDHPDGNSILRVFGNWLFEAISMTDLSFSDGISVAYSSLCQIFTSHQKNPLEDVYLSKFYEGIIRIFSNPNSFGKQICATIANSEKIFSCGLRGVHILIPFYLFVLKKIIPNRSVSFTTNIPLNMLRRSSITILSSLISSPHYFEKTQIISIDSKVLDTSFKDFQSISGIFQNILVSGFMNEQDPINAQMILWLMSSHLHEDISDISSLPSLYISTIQDFITNPNEVQNSWPISCFLVACDVLHSMVYLFNQMNKISPKIVMDLVAKLSAYITNLINQPGNTPQEVINTKISRLYEVISDYITKSQWIYESPMALSDLITSFEAALQMPQAKSKPGISQQVQDFAFIAFMNLYRQVGNFPLPLGPSTKCSLITEKQIMNKFKFSESELLQRTRHFVHENQRILTFIEGIPEKESEESPVFIIIRDLTGRNSWKGKFWILPLSFIKPDEKSIKKHIWEGEVISPVYPRAIKMTEYKQQEMDLRYNLVPLYNFLSSPMEVRYHYTFAFVENQNRVEEVYRFIEESSAVKLFQKRTSRPNHTDKKWQFNMARLLLSNFGYTHPDWLQSLDSIPSSLAILNELKNIDQLPNRYQTTIGVMYLYPGQNRLTDNSHAFMNSNGSSEFEKFILELGWAVSLDKHQGFKGLLTSELVSNGIYYSSFLDEVIFHLPSALTTEESRKAIIQNDSVIIVWCDDPRPFVPDLIRTPKNQVFIVIRPFFTSLYSIQIFNYSTHDIICGPLLNNSIVARPLLAHFVRLTALNYSKELAFQNDSLPNPSVIRKNHIQKFIEGSKLDYPSYDLYHSFFISKEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHV6</accession>
    <name>A0A9Q0LHV6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">M0811_09190</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHV6"/>
    <dbReference type="OMA" id="KHTYKKT"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="846"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="924"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="992"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1031"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="810"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="389"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="493"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="534"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="557"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="590"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="670"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="671"/>
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            <name>ATP</name>
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        </ligand>
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            <name>ATP</name>
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        </ligand>
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        <location>
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            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="764"/>
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            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="784"/>
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        <location>
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            <name>ATP</name>
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            <name>ATP</name>
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        </location>
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            <name>Mg(2+)</name>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004236"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00034036"/>
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            <dbReference type="PIRSR" id="PIRSR606539-1"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF16212"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAJ5072976.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
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    </evidence>
    <sequence length="1169" mass="132377" checksum="20B246200B9AD593" modified="2023-09-13" version="1">MADESTPTRIIQITDQERDKDFPFIGNSIKTTRYNLLTFLPKNLFEQFRRLANFYFLIVIILEYFPFSPLNPTVSVLPLIFVLTITAIREAYEDAQRRKSDKKINNTVAVCLRNGSFKNVKWKDIQVGDIIKVQNGQFFPADIVILSTSEPMSMCYIDTCNLDGETNLKIRQGLQVTSFLAQDEAALSNFHATVQSELPNNRLYNFDAALDYNDETHSLSNQQMLLRGCALRNTKWVIGTVVFTGFDSKIMKNSTRPPSKRSTVEKQLNSRLISIFIFLGIIGIIGAVFASRWQDKYGNSAWYMGDSVNKDNLKPAVIGVYAFFSFIIVCNVMIPISLYVTMEMVKLIQTVFINHDIDMYHDETDTPAKARTSNLSEELGIIEYIFSDKTGTLTCNMMEFMKCTISGISYGNGVTEVAVAAAKREGRILEITRNKDDPAFDDDSLLNNLHNKHETAGMIHEFLTMLSVCHTVIPEKDPKNEGEIIYQASSPDEGALVEAGKLLGFRFHSRTPSTVTVEIEGKDETFEILNVLEFNSRRKRMSVIVKTSDGTIKLYTKGADNMITQRLAPESKYLDETTKHLEMFANEGLRTLCFAMKVIPQDEYEKWNEGFHKANISIEKRKEKLEQSAEEIERNLLLVGASAIEDKLQEGVPEAIELLARAGIKIWVLTGDKQETAINIGFACSLLTTEMTLITISAPNLESTQEALKKAIKEHSNSNNDNIALVIDGATLEFALDGIVKFDLLQLGKMCKAVICCRVSPLQKALVVKLVRDNVNAITLAIGDGANDVSMIQSAHVGIGISGQEGMQAVLASDYAIAQFRFLKKLILVHGRYSYRRITKLIVYSFYKNMAFSIMQVYFSIFAAWSAQTLFDSLLISIFNVVFSSLPIVVISVFDQDVSQDAEIAYPQLYSGGDREFLFGFTRFWLWLLQGVYQGAVLFFVPFLLWRYEPLSDDGIITGLWGMSTGIYTSLIIAINLKIAIETTFWTWMHHVTIWGSIIVWFVFAIVYNLILKAPTMYYVVFHTLKVPVVWLQVLFTVVLCLLPDFFIKYYSRNYRPQDWHIIQERERLGQQLYKPTATKSTMAIKDEIELSDINVEDDTKLSKPTKTQSLFAEKVINYIVDGKPEKFTGFAFSVPRGSSFGVVAKDRTTDFYETDDEIDDGENFERDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI40</accession>
    <name>A0A9Q0LI40_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_09311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI40"/>
    <dbReference type="OMA" id="KFARYTH"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="12">
        <location>
            <begin position="518"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="137"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5072865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="949" mass="108626" checksum="697D8387F6B75738" modified="2023-09-13" version="1">MSENPNKKIKNKKSKSKKQKSKEDKSKEEKKSFLEKIHEKPPINPQPKEEEIQQETRTFQEEQSSDFNEFISDIEEPELKQIDEGSDSVDDLFGENQDEDYESNDELDHYDLNEVDDTEYPNLPIYQRHQIEMDLENKEEKPKSKKSKKSKSQSQSNSNSNSNSKSKSKSQSNSNSKSKSKSKLKLKLQKEIKKPNSILNLGFIQSTETELPSLDDLDFDAIDISLLRKWRTNPEIKREISKRFHNFLVGFSDENGKLTYVEKIKVAGSQNEESLVINYSDLSIKEPKLAMWVADSPMEILPIFDEAAYKVFLEMFESYEQIQPEVHVRISDFPLHDSLRDLRQHHLNTLIKVTGVVTRRTNVFPQLKKVKFVCPHCNSTIGPFVQNSLSEIKVSSCPVCSKKGPFRILEDETIYRNFQKISLQESPGTVSAGRLPRTKEVILLNDLIDSAKPGEEIEVTGVYRHSFQTSLNSQNGFPVFATVIEANFIVNKEDSFESFNLSHEDINEIKKLSKDPKIRERIISSIAPSIYGLKHMKTAIAMALFGGEPKLIGNKHRIRGDLNVLLLGDPSMSKSQILKYVEKTAHRAVFTSGKGASGVGLTYSVRRDSTTGEWTLEGGAFVLADQGFCLIDEFDKMNDHDRTSIHETMEQQSISVSKAGIVTTLRARCSVVAAANPIRGKYDPSLTFSQNVDLSDPILSRFDILCVVRDTVDPIYDEKLAKFVVESHVKSHPNSRAMEQYEKENANEAQFDEGGIELIPQSLLKKYILYAKKNIHPQLTNIDEDKIKKLYSDLRSESAVTGSIPITVRYIESLIRMAESVAKMHLRDYVREDDLNFAIKIMLESFISTQKFSVMKTLRNRMNKYLMYKQDSNELLFYLLQSLVKEKIDYLKLRHQIDAPEVVEVDQEEFEMKAKNMNLIHFSSFYSSSYFVANHFTLDKKNGIISKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIN2</accession>
    <name>A0A9Q0LIN2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-alpha-acetyltransferase 60</fullName>
            <ecNumber evidence="7">2.3.1.259</ecNumber>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_01540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50604"/>
            <dbReference type="Rhea" id="RHEA-COMP:12745"/>
            <dbReference type="Rhea" id="RHEA-COMP:12746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="ChEBI" id="CHEBI:133414"/>
            <dbReference type="EC" id="2.3.1.259"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetyltransferase family. NAA60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.259" evidence="7"/>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIN2"/>
    <dbReference type="OMA" id="PRIDQGY"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="212" mass="24964" checksum="49A1FFDBD7153C00" modified="2023-09-13" version="1">MENSLKKRSQDNLNKDPKALFIEKDFNFGKITKQNIEQVIALDKTLFPIEYDENFYKRLYGPETESIVVITKQTNEIIGVATAKISTKIDDWWYPRIDQGYIMTLGVREDHRRKGIGSYLVSKISTHLFIQKKVESVTLHVKADNKAAINLYKKIGYEESKKLPDFYEINNEKHDAILMNYRYSTFLKNNPKFKQNQKQQKILIKEKTLKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKF4</accession>
    <name>A0A9Q0LKF4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ap endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKF4"/>
    <dbReference type="OrthoDB" id="8033718at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="382"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="827" mass="98856" checksum="0F022ACEC2619EFF" modified="2023-09-13" version="1">MVNWGNLHIFADSPFINIYQILNILKNYYPLRGYWRRVNNTSQGHFQVVYPHRAVREKWRVILRGIKIAISISKPKKKRNFEKKRNKIKQENKVKEDNKETQINTLDASNEIIESETEYILDESSENESEEIDEPNVSVKLTDTKELTQEETICYKNLDSHNWLKTPLILKAQYENSPIKNEEKFQVISNQIEEIITEELKILPKKKIGEADLREFLSKSINYSYKRSFQKYNPYTKKQMKPFQDKIIKKFINKEWEIDSNLKQTIKYKNSKDYTEMNTKKITKIRNSNKIIIQRSFLNIFETLSILNNQYVHRIIQKGEHQMEIWDKNQMINSIFQNCKQKQENIPTKTKIHLINANGDKIETVKGKQEMNDNEYTTNIGSININGLIRLGKTQELEQILLEQKIEIALIQESHLKKRIYFQKYFTFEKEAYGQKKSKGGIAIAVRKEIRKYFHEIPNEDSDILHLKISDMNIITVYIRNKRQNELMKKLQEIIQNLNGEKFIIGGDFNLTEEEINKRKLLPNVVIIPNPENSRTRNIDHFCVNEGIITQPSKIFDTISRKLSDHKLIITSIRIKIPQITTLQYYQPTREEFQIKLLKKVEEETEIGDKLILKPSIIQNLKENFKKRVIVHTETQDKIGFELLNFTQQEKPNWKKMLRKKWKKTIKGIEMDKMNEINYWTEIQRLTQKKKPIKTDPEMRERFKRMIEQIRRHPTETIIQKIKNYEIDIPEDVRKPSLIFPLERLNQTIKMSKNSATCEYDKIDSYKNPYIEENTEKYEEIIKLINRMYKKWIKNPDETTINYLRKRRMIFIFKQGDAENKWGLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKL1</accession>
    <name>A0A9Q0LKL1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inner nuclear membrane protein heh2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKL1"/>
    <dbReference type="OMA" id="TILYHEY"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="527" mass="62591" checksum="C9DDF3686C990BB6" modified="2023-09-13" version="1">MSNKRKSGRKSPITNVNYFQNNNNNNNNNNNNNNFDSDSDDNSFPLLNHPYISKTQQPKKTQKTISNNRNTNIFLQQFNKNIPENQSTEPDPLRIKKKTTPNYIQKSNNNFQQKLQRNSQQRLISTQPQLALNYSQFKNQNLNRNQNLNLNQNLNLKQNLNQNQNQFQNLNQNQFQNLNQNQNQFVNKYPLKSANRQSISKIKSKKKQQTNEIVDFFQSNVKSILITIFFTFLVYYLYKKYFIKTPFCDTGIDPKSQKRKCIACPENGICFKSKLTCKTGYLQIEDRCELDYELNRQIQHEIEKFLKKEYPTKLLECNFQPKLINAFYLKENIAIKKNFTEEAFISALRRIKEITRQETGSRDEMEFLIYRPKVPYFNLCRFQNLIWNNKLIIIFIIILISIVMIILTRRKINKTFHKEANIIAKDIATILYHEYFKAQVDSQVRPFVVVDTIKQTQIDSRSKISSELWFYVEKIISQDQRILEEIRVVNNEPQKVWIWNVGTNSTPIKKNSNLNSNSKFKFKIRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKS3</accession>
    <name>A0A9Q0LKS3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Faciogenital dysplasia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKS3"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="51"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="446" mass="53142" checksum="0DEFA92726221883" modified="2023-09-13" version="1">MIMIMLLRGTKSYFIKKNKIKTKNYNKIIIFQKKKRNLHLQQKLQHQNSTKRKEITLELFQTENSYIKFLDILINKIMNPLQSEGIISEKERKLIFDGLDVIFAYQKEFHKELEPVIKEWNIKTCIGELIIRKISYFRSYISYINNYENSIQCVANLRKKNRRFREFLNESQTQNQNLSIESLLIMPIQRLPRYVLLLEDLFKNTPKNHPDYEHLKKALTEMKATTTKLNDEKSEREKQEKVIEIATKITEHSKSKLGLQIIDPARRLIYTDKFQLNFEQKLFPYQIFIFSDSLLLCQLKKPRFTLKQQVEESKYRLSAKSFIHFSNDIEIHKYIGKEEFSPITVTRRKSKTEQKKSSNVDNISNSNSPLLSLQRDQNVYFFIKISFLNDLNFFVFIAQNQTQRDQFLDKILSQISIFREATKTLKQQFHLQSSILNVKIGIPKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL07</accession>
    <name>A0A9Q0LL07_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nep1/mra1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_07396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL07"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="229"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5075426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="616" mass="71427" checksum="02873EFDEB4B3EFC" modified="2023-09-13" version="1">MQLQINFNLDILDFLLEKGADPNANDQDENTPLHKAAFKGNLEGILSLQRYKAESQPNRYNKKPDYLASRFGNEKCLEALLNPGKIQSERNPTQKQESKKIEEKKEIQENESNQVENESNQSNQENQNENQLNQNENQENQIENQENQENQENQLEDQEDEQEDDAQESESEQSDEDDDQQQEIKSKSKSKSKMKNLQIQQPFIIPKNRVLKYKPSNIKRLNYKPLFQWDLKDVADWIYSIGLEEYVPNFIRNHITGSELPFLTLEILEKEIEIKSFGARRKIAERTALLHSNNSNLDTMNTNLNSFGFVFPQNFQNLENSSQIKKSIGISIFCFIQKSQVENKYFSKENDNKKNSDFFSNFQNQIYIQIYLENPSINLLRNKLSKKLEIEISQINKIITKEEPHIYIIDDDDVAMLKDAPLETIKVGNKYQLLNVDDHHRQIKKKGRDPNEARPDIVHQSLMTLLDSPLNKAGKLQIFIHTQKNVLIEVNPQLRIPRTFKRFAGLMVQLLHTFSIRSTTDSETLLKVIKNPVSDHLPTDCYFIGTSYSSESLVNLKEFVPKLPEKQIVFVIGSMAHGSIDTDYENERIAFSKYPLSASTACAKVCYAFEDYWGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL37</accession>
    <name>A0A9Q0LL37_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL37"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="279"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5074374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="442" mass="52178" checksum="B30F68F33DDD2FF7" modified="2023-09-13" version="1">MDNNNNNQIENANQNENENEMKNLEKKVTKNLIKDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKISNSINYSNFFQFLFQNRNLNSNEIEIKYSISKQDFDKLKQFDFFPKSFLVDIQNKVIQDNQKEIEEKEKEIEEKWKKEVEKKLKENQQMKIEIEEKWKKEIEDKNKEIEDKWKKENQDLKTENEKMKQEMELQKIFSDSEIVKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDGKGKTLVIIKTKQNFIFGGFTQVGFNGNTGQINDSNAFIFSLRNDKGDRIPAKFTIQKGPCFGNNDIYLNSNFQPGYLNFGSDFNTPNGITYNTNEAKSYLAGSYSSWVVDEVESYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL60</accession>
    <name>A0A9Q0LL60_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_07996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL60"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="88" mass="10614" checksum="17B71E8F4B3288E8" modified="2023-09-13" version="1">MRSELYRGMFLSVTNDNSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLIKKFNNQNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLD7</accession>
    <name>A0A9Q0LLD7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Condensin-2 complex subunit g2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="FKAWKMA"/>
    <dbReference type="OrthoDB" id="10062843at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199:SF4">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1328" mass="155839" checksum="4CCE71E495EF3F76" modified="2023-09-13" version="1">MTTELTRKLIDSSQNNLDSFISFMVKLKTPLKEMIQTLNKRSSMKIWENLNHLFNKIIQENLYIFDTNIQNRIHYLKGLFHLATLIESFLEEKKQFLPNACFEMIVGLHDSIFLMRQERKNDPISYSTPTKKQEKNETNENENENENENENGKENTMEIEIQNEDLSKDQLDNLIEQENSKILLFQEKVVQICEKYYLLEKEERERIVPQMISYLVLVSLDLSAKPAHIKRLYSTRSSLLLLDFSDESTTWLKNLLLRCFISPLFLKTEEGKKFLVYLFGLYPPFIDQIHATIKNQLPVSSSAIIDIFGEIYFKAWKMAVSSYRVRIEYSCIQDLMNHAIHASTPKMTKVLHQLLSKIHTQKNFRGVDEMLLRLYEPILFRSLNVSNPLVRKNAALLLIDAFPLQDPDSLHEEIDQILQIQFDHLTNLMTDSCVPVRSVAVQGVCRILSIFWELIPSEISQSFLNLIFHDLIYDKSSSSFRVAVIKGISYLLDSHLVQTSLKKFLPSIRSMINDKVESVRLAFIHLLIQIKNLRFIKFYEVVPLKFLLYRLAKDNIFASQQGYPNQLSVGESIKKINSNADKIGERITSLLLSTYFPHETHHGSELIYRCLRLMKKNIVAAKIFFYYLTRVAPLDSICRLVILFMKILDRCYNTKMMGAEQSFLDVLKSTRNSTKPNQEQEQEQEQNDQEKEKEKEQNDQKKSKKRKSKRKKSKEERKREIEPSYKEFEFEFEPQILHIVSILVEGIEPSISDKKNKKLKDFLSNVFNNSFLSDFYDAFPSALTHSSILKIVSFHSDSSVIDISISKIKDLPNQDFSKLPLYYQDEVYYGSLVDCLVKNGKEVLLLNLIRDWILEPFSSMKKEAENEKKEKTKSKKRKSKAKSPEPNTSAEWKMLEQKAFVAIKLLDYMMKTESNRRVVVTHDEISDLIIVLQQYHLIISYRISSEKNQNFISDDLLLELLQVEGKSLISLFTQLSLEPLDPTEQFEDETPPIFLNIVDWFFQGIVPALQKIKVQKNKEQNSDDIEPEMINKNFVEKISELLFVIITESVSLGILDSKTRNDISSHFINLLEDDQSNLFIDFFLSRLLKLLYQLIFKEIDPPSNQNQTQKLMFLIFSLIHSQQNENENENENENENKNKNKNKNQNINANLMDSFLSEILTLFLQRNRLKFIMESFVHFILQIGENKLNEMENQDVFFQSFDDFSFSTFLIMKTILRRKDFTKNLLLRIILPILENEQTKPEQLWGLIQILHLIQQKEKNQQDELKKKFPNKEFKLFKFPDQILNQLQLIREYINNNNNNENENENENEQINLENCVSLMIESFLDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLQ8</accession>
    <name>A0A9Q0LLQ8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLQ8"/>
    <dbReference type="OMA" id="GGRGCYP"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000009">
        <property type="entry name" value="Ubiquitin-60S ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="99" mass="11298" checksum="4C97A3854B3DD3B2" modified="2023-09-13" version="1">MNFQIFVKTLTGRTITLDVDPNDSIENIKSKIQEKEGISPEQQRLIFAGKQLEDSRTLNDYSIQKESTIHLVLRLRGGNFQIFVKTLTGRTITLDVGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMK4</accession>
    <name>A0A9Q0LMK4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_07143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMK4"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="146"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5075573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="456" mass="51235" checksum="0DD5CA8B6AC2C634" modified="2023-09-13" version="1">MQENQNQNQNQQNPNQQKQQNPNQKNKPKAKNKPKGKGKGKGKGKGKGKGKGKNNPKTESKYKEKTESKQPKSSKKEARKTENITSEGAKQEQTSPPTIPVDELFEDKNFPIGIEMEYPNDNTSRITNEELRMKERMMLSDILPYLRKAAEVHRQTRQFANAFIRPGIKLWDMCVEIEEMNRKLISAQGLEAGLAFPTGCSINNCAAHYTPNKGDDRTLGKSDVMKIDFGLHINGYIIDSAYTVCFDPKFDPLLKASREATNAAVKAAGIDVRLCDLGEIIQEVIESHEVEIDGKVHNIVPIQNLSGHSLGPYEIHSGKSVPLVKGTEQKTRMEEGELFAFETFASTGKGVVSDENPTSHYMMRPDTSISLVTNPKARPLYHVIEKNFGTLAFCPRWLDRLDQTRYLFNLKHLVDSNVVRPYPPLSDINGSFVSQFEHTLILKPSCKEVLSKGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMT0</accession>
    <name>A0A9Q0LMT0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Af4/fmr2 family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMT0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043640">
        <property type="entry name" value="AF4/FMR2_CHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18876">
        <property type="entry name" value="AFF4_CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AF4/FMR2 C-terminal homology" evidence="2">
        <location>
            <begin position="158"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5075767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="330" mass="38923" checksum="9B4F07A55A387029" modified="2023-09-13" version="1">MSTQSIQSILTEMALPLLSELPDSLRNYSNLTTKSNKKRKSPYVSEEKQEKKKEKIKIKEKEKEKIIKTKNKSNETKENKENKPETIKQDQGIRKWNLNEYKHKLARNNRTNSPNEKEKEKEKEKEKEIEIEETSENNNSLMNEKDYEKKGESLSNIGKELKHEADKLKDKQQSAITYFKAGIKFLESGECYEMAGKLNPRFIGIAARMYDKTTPFLEFCSERFNSQNLKKLCSLCHLCIAVTEMRTFLIHKNKLRQFQKISITMKEKNQQIDQEKQFTFMRNIGHIFRAFEASEKYDRLNIDSKKFHDFTSSSISQVIQFVRNSVDFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMX7</accession>
    <name>A0A9Q0LMX7_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">propionyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">M0811_07445</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23721"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMX7"/>
    <dbReference type="OMA" id="QVLCDEH"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041265">
        <property type="entry name" value="PCC_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18140">
        <property type="entry name" value="PCC_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="16">
        <location>
            <begin position="14"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAJ5075475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="678" mass="76827" checksum="9CDCD20F7B2D5A57" modified="2023-09-13" version="1">MNYRIPSFSSSLGIFKKILIANRGEIACSIINTAKKMKIKTVAIHSPIEYNSLHVKLADESINIDSYDPKSSYMDINKIIQAAKKTGVQAIHPGYGFWSEDPEYAQEVLNNGFAFIGPNTKAMSIISSKSQSKQFAQKLKINFVPGNLENITSVEQTVNFANQIGFPIMMKCKNRQGSIFHVARNEDEVYSSFPLIQDELNSVFGNCELVVEKLIEDTHHISIQIIGDNYGNVVYLNDCDCSIQRRNGKFVEESPAFVLDESTRRKLGFESVLLAKALNYNSAGTCEFLFNSKTKETMFLEMNPRIPVENNLTKFTTGIDLIELMIRISAGEKLPFNQSQIKLNGCASEVRIYAEDPQKGFLPSIGTIIKYSEPDPRNKYLFCQSGVVEGDEITTHYDPLLSILVTFGKTRTSALKEMKIALEDYVIEGVNQNISFLRALLDQKDYNSGNFSTQYIEKYWPEGFKGVELKEESSIHLVASSVVIDTIRKLRDYTISGNLEPSNFRNEEIVVQLMNKEYSCFVLDFSDNAFVVEIDKKIIYVDDVDWTVDGYLFKAFVDGIPVTVQVVESLTHGYIIRYIGTKFQILVGSKRMFELLKWMPQKKEIDQLKFIAAPMAGKIYSMTQKKSGDSVHKGEELFVIEAMKMQNRLVAKNYSTIKSIFKETGDKVSVDEILIEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN05</accession>
    <name>A0A9Q0LN05_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN05"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="238" mass="28172" checksum="CE82527238D824C6" modified="2023-09-13" version="1">MNGIVLISTLIILNIYIDLKKSISIPKLFLLSELDLIITIFWIIYSKLNFYSFQEYYLLLNLIITGLILMILISLKTIFIFNFIPWLIILIPPIIFLIYLISYIYQLIQQIAGYSKDEIVYLMFILGLIYLIIVLLFTGLKLDEFIEIKYSKLIYLLIIFEIYILYHMKKEIGTFCQFIGMLLFFVVILIILLRIFLYGDGIIQKLFRALFLIYTILFIPFLLSFAIFFSSGFKLIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN60</accession>
    <name>A0A9Q0LN60_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription elongation factor tfiis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN60"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="6">
        <location>
            <begin position="132"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="290" mass="34414" checksum="8BCBCD9CF77DD359" modified="2023-09-13" version="1">MEKKINDLRQKITNELLTSNSVDEKLLVSFLEKLYSFENINCEIILNTDIGILINKLRFVGSTQTQKIAKQIFTKWSKIIQNENKNKSKIIKPYLMPEKTDNLNQNLNQTKTVVKRISDVDFFKGKKTGNQKRDQMKILFFEELKNFFNNFQSEHKVDIFSIIDEMEEAIYESKKRESIQNYRSKCRFIMANLIKDNEKSLELRQDLFLGKLDPKKLSEFENSHFMTEKQKEDHEKLIEQGINDALTPEFNKEENSTDFLCEKCNQKRCKIWTLQTLRADEPMTVYICNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNA9</accession>
    <name>A0A9Q0LNA9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNA9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="262" mass="30883" checksum="58151A6FB8587983" modified="2023-09-13" version="1">MNINQNENLTQNQNQYQKNQKSKSESQSQSQSESESYSESENENENENENENENENENENENETNNSKKIKNQNQNQKPKRNLLSELNMFNGMNINQTKTPQIKQQNNNSFMSDLSFIENKDQKIQEKQNSFFGINPINQKQEPIKTNEDLLSIFDTNRTQTQTQTEVNDFDIFIGKKEQQVNPKKNKLSLSHKKLKSSREIRIPFNRKKQNQQNNSNQKDVFNEFLNLIPDKQEEKKDFPQNSNSFSMFDSLEIVSNQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNG3</accession>
    <name>A0A9Q0LNG3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine protease rdl2-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNG3"/>
    <dbReference type="OMA" id="EATNDIW"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000039">
        <property type="entry name" value="Cysteine proteinase 2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040270203" evidence="3">
        <location>
            <begin position="16"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="5">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="316" mass="34806" checksum="8575C2D0A358C780" modified="2023-09-13" version="1">MKAIILVLLIVFVTCSPYQKMFEKFKAKYNKQYSEEEEAMRYKIFRDNVKIIEAHNKKGSSSRLGVNKFADLTSAEFQSKYLKPIKIEDQKETVSPRVKDLPTSINWKDKGAVTPVKNQGSCGSCWSFSTTGAIEGCTEIASGKLNSLSEQELVDCDKTDQGCDGGLMENALQWVIDNKGLCSEKDYPYVGVDQSCTKDKCQSVSTLTGYQTITKGDLTGLATACAEHGPISVGVDASIMWQFYIGGVLLDIECGKTIDHGVLLVGYDTDATIKYWLVKNSWGASWGESGYIKLEYDKDTCGIADYANYGTGCQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQK9</accession>
    <name>A0A9Q0LQK9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQK9"/>
    <dbReference type="OrthoDB" id="2306477at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
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        <property type="entry name" value="Ank"/>
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    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="29"/>
            <end position="62"/>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="200"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="201"/>
            <end position="235"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="236"/>
            <end position="270"/>
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    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="271"/>
            <end position="304"/>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="340"/>
            <end position="373"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="473"/>
            <end position="505"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="506"/>
            <end position="538"/>
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    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="794"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="588"/>
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    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="722"/>
            <end position="762"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="588"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50097"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
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    <sequence length="893" mass="103084" checksum="0DE2E152253BB105" modified="2023-09-13" version="1">MNTWKAIEENNIEYLKRIEAIPANELIKENKPILHFAISKQVSKEIIELLLSKGIDINSKTNQNETALHFACKENISIEIINLLIENGIDINAKTNWYNGTALHIACKNPNISFEIIKLLVEKGIDINSKTNDNETALHIACKENISLEIIKSLIEKGIDINSKINNNETALHYACKENISLEIIKLLIENGIDINAKTNDSVTALHLACKNRNISFEIIKLLIEKGIDINSKTEYNETALHIACKNRNISFEIIKLLIEKGIDINAKTNKNETALHYACQNNISFEIIKFLIENGADINLKTESDKKVLHIACQNPNISLEIIKLLIEKGIDINSKTNYNETALHFACQNNTSLEIIKLLIEKGIDINSKTNDNETALHIACEKNLKEIVEFLILKGAKNIKDETIGETLHLVSGNNSFEWIKFLISKGMSINSKNRFKKTPLYIACENKSSIEVIKFLVENGADINSKTDQNHTPLHISCRNKSFEIVKYLIENGADINSKTYQNHTPLHISCRNKSFEIVKYLIENGADINIKDSSKQTPFTIILQYLSPFEITKLLKQIGINTNTNENENENKNGNENGNENKNESYFSISMKKKLIKLLLMNNANILDLKEKQITKELIQLFSKIHSINQDLNNLLKSNEDNNLSDLEIESIDNFKFKVHKLILLTRFNNNQLILQKFINICKSKSKEEVQIILNFIYSGFFDYDKIIENLNEISNSNQLERKMNESIEIISRKEEENKYKEEEKEKEKQIEELFKEIGFDSNWIESKKGRKGILKDFQKLYEENEIKKDFTIIVEEKEIKVHKLILFLRSELFKGMFQLNIQDSSNQVHDYSEKSNETIQQLIYFLYHDKFEENKINEKIIEELEDIKDFYQLNQNSIIDLLLEKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR13</accession>
    <name>A0A9Q0LR13_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Intein-containing sodium/potassium-transporting atpase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_05019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ISWEWAL"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030908">
        <property type="term" value="P:protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000038">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1178"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1206"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1247"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1314"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1349"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1381"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="96"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5078231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1419" mass="160280" checksum="615F8B6070687463" modified="2023-09-13" version="1">MSSDWFEKSETEKQTAPYENDRELELFDIENSISRHNSEANQAEILPELNTPKSLQRKFSSNEISIKKFEAKKDEKQGKRVNKDILNDLKKEISMNHHQMDLDELYLLAGTDPIHGLTEEQARESLRVNGPNCLKPPKSTPEIVKFLKQMTGGFSLLLLVGGILCFIGYGLDTSTKDNLYLGLVLVGIVIFTGIFSYYQEHKSGKIMEGFKKLVPQISVVIRDGKQKTIDATQIVPGDIILVKAGDKIPADIRIIESSDFQVDNSSLTGESDPQSRTVKCTSENPLETANLAFYSTLATQGHAKGVSIFTGDSTVIGRIAGLAAATKTEDTPIRIEIRNFIKIITIVSVILGVLFFTYGMISKTSWITNVIFMIGIIVANVPEGILTSVAVTLALTANRMSKRSVLVKNLEAVETLGSTCTIASDKCLGLNTPIMMYNGSIKLVQDVLCGEKLMGDDSKPRNVLSTTKGFGKMYRITPEKAQYFTANYCHILCLRSHFPTSSIYDSQSSFIVQFNLNHSISQKIFPYSMNNKLKVKKDAEKFIQFIENSNKAIEQGFIRYGSIVHIIVEDFLRLETEIQSSYKLYKADLDTIIQSNTSLDIDSYTFGVWIGARELSSFRKLSETIPTKIKKELSSNLNEPENIIPNDTFSFLENQYRSYFSNSNFVIDNGIPDQYRLNSRENRKKLLSGILDSREFVANPKYSENHFDFVITSEKFKQDFQQLCNSLGFDVQIETEKRNKFGAIHKIKLIGNEKENDQVISIEYIGNDEFYGFEIDGNRRFLLGDFTVTHNTGTLTQNKMSVTHLWYDNRIYSSDITLETDCYDKTSEAFQQLMNVATLCNREEYQPDNKEKLAGNASEIALINFFGPLYDPKEVRKSHPQIKELPFNSTNKFMLTIHQISQDSEEVILMMKGAPERIITRCSTIMINGEELELTEEWRRRYEEANEIFADNGERVLGFCQLRLPYPKYSKSYPFDVTEFNFPIETGMCLVGLVSLIDPPRPSVSSAVAKCKTAGIKVIMVTGDHPTTAKAIAKQVGIIWSETVDEYSRRTGIDTALVTPKDAQAIVIHGAQLKDMDEDQLDRVLQFPQIVFARTSPQQKLLIVEGCQRRKEVVAVTGDGVNDSPALKKADIGIAMGITGSDVSKEAADMILLDDNFSSIVNGVEEGRIIFDNLKKTIAYTLTSNIPEIVPFLLFIIISIPLPLTTVLMLCIDLGTDIFPAISLAYEKAEQDIMKRKPRNAKTDRLVTYKLISFSYLQIGMIQAFASLFTYFVVLGNYGFKPQELLFLNKDWVSKSKIINGLDYAKRVNALKNAQTAVFVSIVIVQWSCLLISKTRRLSIFHQGMRNHILNLGLFTETLLAAVLTYIPWINPIFGTQPIRFVYWLPALPFSLYILVYDELRKYFMRRNPGGWIEKNTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR44</accession>
    <name>A0A9Q0LR44_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_05975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR44"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5077452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="161" mass="19058" checksum="4166A29621178CA0" modified="2023-09-13" version="1">MEMKMEMEMEMKMEMKMEMKMKMKSNQKKSNTIEENSNKVEQKGTKILIKKTGHSSENLGLNLFSISSLDTQHFILTSTTKLKRGKILKIMKCFFKKRHISVQKLSKAKFLCRIDKTKFQVSLLDFKEKELAKFSKIEFEMQEGDFLTFQKLWLALKPKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTI0</accession>
    <name>A0A9Q0LTI0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase m20 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_05047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTI0"/>
    <dbReference type="OMA" id="LSNHEGP"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="245"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5078259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="510" mass="57826" checksum="A34AA1360C87AB88" modified="2023-09-13" version="1">MEKNELDIETEKLSTKYLPLAIEILKEAIRIPEDYLETDSQCGLSNHEGPRMEFFKKTIIEQKCVEKPEDVWFDAYGNIGWMVQDCDDGIDPDKKKIVYFDGHCDTVKALRPLWKKLGGGVDPYKGLIDSEKVDLEKIKENLGYIPPKSEWENLVFGRGSADQLAGVVSQMIATKIMLELKKLGSLKGVIIRSFGTACEEDNDGGGPMYIIRNELSGKSPQYIPDCCIFTEGTGDSTRSALGIYIGQRGRLINEIEIIGKSAHGSMPHLGKNPIEYGSLIIKEAAERAVKMEGFLDHEFLGRGTRTCSWAFLDTPSDCAVPERFVFRFDRRITIGETPKQTIDDLESFESVKKARDDGLTVNIRIPQYTETTWKGYKCNNEQIYMSWITPKTHPAIQSAVETYKSIVTPFLPKDQVETTTNIHKEPRVDRWIFSTDGVGYPVPKDYEKFTVPESKNWCSNEDYKWPAMFGIGAGFEQNTHKIGEYVDSRELKHAISFLARFPNVFAQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUB7</accession>
    <name>A0A9Q0LUB7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUB7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="4">
        <location>
            <begin position="184"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="334" mass="38330" checksum="7D083CB5C67792C0" modified="2023-09-13" version="1">MRKKKGIETIIKSMNNFPNDNLLHQFGFSILANISFQNEKNQNEIIEKGGIETIIKSMNNFPNDNTIQIFGIKTLAFISFQNEKNQNEIGEKKGIETIIKSMNNFPNNQNIQKFGFLALWNISFQNEKNQNEIIEKGGIETIIKSMNNFPNDQNIQYNGCGALANISLENEKNQNKIREKKGIETIIKSMNNFPNNQEIQINGCVALANISFENEKNQNEIREKKGIETIIKSMNNFPNNQEIQMNGCGILMIFSNLNDKRIETIIKSMNNFPNDQEIQFIGCETLLNLCSNEKNKNEIKRLKGIEIIQKLMINFINDKNLQSIGKEILKKLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUS8</accession>
    <name>A0A9Q0LUS8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lim domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_03861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUS8"/>
    <dbReference type="OMA" id="SACHREI"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd09401">
        <property type="entry name" value="LIM_TLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="244"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="316"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="398"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5080376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="56930" checksum="D8DBA468CD907AEB" modified="2023-09-13" version="1">MSWYCTKCGKLIYQMEKIDALDRHWHKACFTCTSCGERLNRAKYSEHNNQPYCHTCYNRLFRQSGYGMGANLSSYRDQPEVIEKMRHDQVKAGNKKKTWGSGGTFLRPSDSYSSPKSSPKTSFNRSSPTNNSFNRSSPTNNLSPTYRCSACHREITGKIIEVDDRHYHEQCFCCFKCDRQLSTTEFFFENGHYYCGGCHEKLTKPKFEETERNITRINSTPKTQSPYRTRSPNTQVVYDIKDLPTCTKCFKKIEGEVARVDGNDYHPSCFTCYRCDIGLAHRPFFKEDGHYYCQKCLDLMTTSKTNYVIDSRSKSLTCETCGLPISSGVVEALGKSYHPNCFLCSKCGLKLRPSKFYEYYGKPICELCHDKEVGPGPSFKNTRTTTRTSPIVKSEPSLYCHTCNLAITSGAIEALNRYYHPNCFICSRCGKKLSTSKFFEQYGNPICERCHDDIVNPHLKNKTTFKVQKTTPKVKRVQPKPKVRKEKKTYLFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LUU6</accession>
    <name>A0A9Q0LUU6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LUU6"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="229"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="334" mass="39575" checksum="01EBB3FF922FBC10" modified="2023-09-13" version="1">MLIEEEDGKRKLYSCGDSNYNGLDKNTYEFTEIKSSLFENDDNILEISCGINHTLILTSNSKLIVFGNNSYHELGTGDTKNQLIPIQIELPKLRFNEDISNYHLSCGFYNSFLYYSPFLSSFSNLEEDLIKLFGRKEFCNISFKTKNGEIIKAHKLILKYRLNENQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIIEEIKTGIDYFQLNQRNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVS2</accession>
    <name>A0A9Q0LVS2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sesquipedalian</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000027">
        <property type="protein sequence ID" value="KAJ5079561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVS2"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="77"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="604" mass="71676" checksum="6E3B17C430ADF8FD" modified="2023-09-13" version="1">MDEFEEVVGVWLTPEKKRDQTYLRYHHGSKELHGCAAVFDQNSIPTEIEFFYHNWRIASFGSFQGHLIPKEDPKQRLIRLQGFLKKEGGRHKSVKKRWFELDDFKLTYSKNQNSPSIDEIKLRSVFSLSKQHDKNQINLHTTNRIYVIQPESHSGFQTWYNAIHKINELRKLVDQNLPIAKCFLDQTIQPVDQLMIDKIQKGNLNKKNVHHFKNINGEGLFLHFLKLNSQDLLLELLKLDYNFKVTNELSKINEEQHKQYFKEWDNKELILHFLDVLNSLNFSISFEILEYWYSSLVIKNQNTENQEHDKIETSDNFSQEFISKDIRISKFDEASRLLKEKIKLTEIFHKREKQLDLNETVYLSELTNIMNHLSKHQMILASLQKTFDQNRETIESLEKEINGDDESEQVDEPQDSQNEKIEELENYKKIISNLKDDLNSKTKMIQDYQKQGDSPKFPRSNISKAPQNQLQEIENEINENKKSFNKLKEENKNETNQKSQEMDKLKQELESKEMLIESERKKIVKLKELKDRAIADIAREKSKIKAITVSNQKILEKNQKKKEDLAARLQKLKLEMQTEKNRNKRINEQIEKTKKQIEESSKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWZ4</accession>
    <name>A0A9Q0LWZ4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWZ4"/>
    <dbReference type="OrthoDB" id="47107at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="438" mass="50565" checksum="98034C5F65D86C7F" modified="2023-09-13" version="1">MNEILFFGSNENPRLLLNKSEKITKPIQFKFENENEKQIKQILSGIYSTIFLFKNGKAIEYLRNPNQQNPEKIQIEENIQKVSVGSGNEAILTKEGNVFAKGIDINPKNSKEFINISSLIEDTNDRIIQDIAYGYQSIYLLTSNQNAYGIGSNKYGQLSLSSKIIIKKHKNLNRKTRKSEKPILMMKNVSKIFSGSYSNFVFLLNSNQELFVCGNNRFGSLGLGFRKKQIRKLTKIQNIPKGEIIDIQCGNNYSIMLIENENEDENLKRKLYSCGNHRFNGLGKNENTYEFTEIKSSLFENDDNILEISIGYYHTLILTSNTKQMIGFGLNLFGQLGTGDTKRQSIPIQIELPELRFNEDIYNYHVSCGNYKSFLYYSPPSFSNLEEDLIKIFRRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQNEKLQEIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX51</accession>
    <name>A0A9Q0LX51_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX51"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="155" mass="18771" checksum="62E82702849D14B9" modified="2023-09-13" version="1">MIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIKITQEIIEEIKTGIDYFQLNQTNPNLFDLLINKFNNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4A5</accession>
    <name>A0A9Q0R4A5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000137">
        <property type="protein sequence ID" value="KAJ5066687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4A5"/>
    <dbReference type="OMA" id="YVLESVN"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5066687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="263" mass="31487" checksum="C181E9EA8A20625C" modified="2023-09-13" version="1">MNYKIFFFLFWILTPFIIYYSINLFHFNEKQIQKLSNNYNLKSKKVLLIFAHPDDECMFFGTTIQILEKNGFEIHWLCLSTGNYRNQGEKRKIELLESGTIFNIPKNKIHIYDHPQIQDGYPFNESLIAEIIENEIDSLDINFIITFDENGISNHKNHISIFNSIQKVLEHRNNNKIPGKSLLVLKLKTVSVFRKYLSFLDFFLDQLKCLFFNNKNHFSITFFSLPFQSIQAMLQHKSQLVWFRYLYVIFSRYMFLNTLELIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5S6</accession>
    <name>A0A9Q0R5S6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_12916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000127">
        <property type="protein sequence ID" value="KAJ5067466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="811"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="851"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1308" mass="151055" checksum="DCC7937BF82D2EE7" modified="2023-09-13" version="1">MSNKNNKNQKNKKQTSLRKIIIFPVNYQLLSQQVPKPYIIIWGNIFTSCVGVNEENIIQHKNSLENLMLLNQIQKFPTEKIKIKFRWKIKKVSRTQIQINISIINLICAIDIMMNEFKMKNSLLESLPKILSKIKSKELSAIVRFFETKKNSCRLEIFNSFIDLIQIISANFLEKSDLESFKNLCSSVIPSLSKAKKSQTFANTFSKSYSDDNFFKEFEPSEQNPFYPVFFLQWQIPFKKFSINESKTTAGMVMERYREQQDISDLQIFVGKDNKKLLRIFQMESLFNKYSEGGKRNVIVIFRSQEIEPNKLISEVTTGYPPLVIKKKLLQIPIYFPSNITDQVEQSLKIVSTDILISKILKKIISSTKLSLDEYGLFICAEMNQNQNHNQNHNQNQNNFVKEFSSTFVFSKLNSEDIGSENSGVFAEQKNIRLKLSVNEFLINSYKFGIWLDPNSKDKISVKLNELMTNNNLVLQFKPKPIKISCFIKISLTSTRMEAIIEKIVLIEKSITTETFLNELKKQIMIPKTKDQKIIALLKKEIVKKKNKKKIMKEKLVKLEENLKMGEQGVENDSFLKIICFEMATEGEDDSDEDDLLGMLRNDSVNFWDEYKCQTTNIRVHKENAIQNEKKSFITFLNSRDLSKKVSKKEKGLKEFFLIQATSLNKAVELLTAEKQLYFFRKMVIRLIHFFIDSGDFVKKLVEVYRGGESRSDIDAKEMERIKSRSLKLLVVFLHARYKFGLIIKPTTRRVINNFCWNDLLLSTDSGVVKNGCEIENLIDRISSNENLVPSLTRTISQIIKGVEDRKKTTSDVTSAFFSETETEKKPTQKSESSHLPHSSTPHITTANETTDTKTSELSDSQKKEIDKKNLDPIPQDDDFVPDFSDEFEEIDLENIDNIPQLNSPTKNNGAQIVIDDDFVGDFNETNGFGMDLLSEHGADKTLSFLLGTAEANLQMDSPDEMMSLETQNDMPPDLDLGKLLEFGEDSKFIQVFMNKQINDDFIDQLIEKNQIDSVNSDDIINFLLQDIDEDSDEQSKHTKKDEDEKTSPSENTDEVGLKPQVNITIDKSDIPPIANIRISQFAKHLTLVSSSMFNGVTIKEWLSRNKKFQKIHSDKLISKIIRNFNQITDWVTLSILSERDMTRRIETITRFIQLANYLQSLGNFNDLMAVMAGLQSNHVFRLRKTWGNVPRKSLEMFKFLDNLTTINQFRGLRNAFLESKSAIVPYIGVFLFDFAYLNELQDQVFGLINWAKLRRLFIILYQIQQTQKFAYNFVPNGKMENILRAVFALNISPDYLSQLSLKIEPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5V0</accession>
    <name>A0A9Q0R5V0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5V0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="168"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="360" mass="42819" checksum="DCCFE3DFB817BBE9" modified="2023-09-13" version="1">MDNNDNNNQIENANQNENENEINKRLKGKKEKEKEKEKGIEKKRLFHSFFSLFDKDSISKQDFDKLKQFQIFLPNSFLVDIQTQVIQDNQKEVENKDKEVEKKEKEIDKKEKENQQMKIEIEEKWKKEVEKMKPTFDKYGDQYQKDLEFEKKLKLIKKNFPQFSNSKIITEEEYIKKLQEWINDNDFFFKMKKRYSAKRNGFSARKWHKAVDGKGKTLVIIKTKQNFIFGGFTQVGWTTDKSKWNEKNLKKNYGWINDKNAFIFSLRNDKGDRKPEKFTIKKGQEQYAIFYNYKDRGPTFGGFGFSGDVSIASTLQCRRTNFGGRYNLPDGITYNTDEAKSYLAGSHSSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6N1</accession>
    <name>A0A9Q0R6N1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6N1"/>
    <dbReference type="OrthoDB" id="7547024at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="228" mass="26994" checksum="C183F7A6EA396D48" modified="2023-09-13" version="1">MLIEDQNQNQNPKRKLYSCGYCRYNGLSKEKEDTYEFTEIKSSLFENDYILEISVGDYHTLILTEKGKLIGFGRNLFNELGIVNTNNQFIPIQIELPKLRFNENISNYHILCGYRNSFLYYSLFLSSFSNLEEDLIKLFKRKEFCDISFKTKNGEIISAHKLILEYRLNQNQIEKLKEIISNKSIKESNQIFEMIYSNNSKINPILYSEIKEIINSNEKLKKQLKEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R732</accession>
    <name>A0A9Q0R732_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Disks large</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R732"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="186"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="301" mass="35879" checksum="0DBAE925D4C74522" modified="2023-09-13" version="1">MTNLNSLDKKTKLNLLRSEYKKLAKIFKEYQEKQKTDLQTIQSIKEENQHLSNLIEEKTEFISKQKNILSEKKLKLEKIQQKTEETKKELEEFSEKHDKLKKELENFNIKTQNLKILEQDRDSLKEQQEEMMKELETKEAEKLRLMEEIEKIQKELDDSNLKIADIDKKIKTTVELRTEAQKKEDKKVRDIFKLPSTEFFYNSYFCWKALSNGTLYLTTSYIGFKPRLLKKPFAFPIRDIVQIEKKKNVTNIDNSIEITRKSKKETIFFASFLVGKRDRCVTDIISQAKKLDHEIIVKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7I3</accession>
    <name>A0A9Q0R7I3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mob kinase activator-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7I3"/>
    <dbReference type="OMA" id="HKHAKAT"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="207" mass="24005" checksum="B63094DFC19C2919" modified="2023-09-13" version="1">MSFFGFMKDKTMRTRKKFDHGTKRYSLYKHSVATLGSKNVRDAVKLPEGESLNDWIAVAIVDFYNKVNLLVGAIEGDCTKESCPSMTAGPKFEFFWAEKKKLVRITATEYIQRVLDYVASELDNENTFPPDPSKPFPKNFLEIASNIFKRIFRIFAHIYYSHFQQITDIGAEAHLNTTFKHFIYFVQEFKLIKQADLEPLSELISTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7N4</accession>
    <name>A0A9Q0R7N4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Keratin-associated protein 21-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000111">
        <property type="protein sequence ID" value="KAJ5068909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7N4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040473622" evidence="3">
        <location>
            <begin position="21"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="465" mass="52320" checksum="628CD84E99601F1F" modified="2023-09-13" version="1">MFLFHLILTFFLHVMNGVYATILAWVQSPNHGKMGTFTLLASSNFIGLIFYVSLQLIHVRKEPNKISKLFICYHLKGYPRSAWILTFFTAIVWVLANFSTVYSFRYASHPSVVQGLSLLMPFMVFFISKVFKISKKLPRFIIPAFFISVGGCLMMILGVNKSQDDNEVPNTNNTAAITLAILFDIFAAFFFSFQQKICRTYKIRAEVLLILIKQIYIPSTLALSFILKEDWGVFKTLGVEGWMFMLYITIGIMCLSRLGQTKMVIEIGAALYSSVQAVRLPSTMVSDYVVLKANPHWPLQYIGAIIVFISISLFLGYQAYADRKTKLLRFIFDPYTFIFVEETEFEDEFTLINPIKNAGANFHMESLMSDHETETETEKENQNGNGNGNGNGNGNGNGNGNENGNGNGNGNGNGNGNGREREIQKKKIQIIISTSSSDSSNSDDFDSNESSEIKNLDEIVEIDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8P7</accession>
    <name>A0A9Q0R8P7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8P7"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="261"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="481"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="588" mass="68396" checksum="18F926A29687AB91" modified="2023-09-13" version="1">MNDCLFFGWNNDPKFIKNESNKITKPTQFKFENENEKQIKQISTGNYSTIFLFKNGKAIQYLKNSNEKPQKIQIEENIQKVIAGDNNEAILTSEGNLFAKISTNQFLKLPNEFINISSLIEDTNDRIIEDFVCSAFAIYLLTSNQNAYGIGSNRNCELGFDSEILKKTEKPILMMKNVSKIFSGSFSKHVFLLNSNQELFGSGSNYHGQLGLGESRKKEINIQKLTKIQNIPKGKIIDIKCGHAHSIMLIENENQNQNPKRKLYSCGNWEFNGLGKTEDTYEFTEIKSSLFENDDNILDFSVGNEHTLILTSNSKLITFGGNWYGQLGTGDTKKQTIPIQIELPKLRFNEDIYNYHISCGDYKSFIYYSPPSFSNLEEDLIKLFKRKEFCNISFKTENEEIISAHKLILETIIGQDENQNEKLKEIISNKSIKESNQIFEIIYSNNFKINPKLYEEIEIDMNLFGSIEEKMKELIEFEEVKDIIIERKEKQYKFPKLILIMRSELYREKFLSVTEGDSTKFTDYSELSDKSFQILEYWIYSNQIKEEIQITQEIINEIQKGIDYFQLNQTNPNLFDLLINKFKNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAD0</accession>
    <name>A0A9Q0RAD0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAD0"/>
    <dbReference type="OrthoDB" id="5560627at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="59"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="4">
        <location>
            <begin position="398"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="576" mass="69020" checksum="9066F990042FECAD" modified="2023-09-13" version="1">MDNNNNQIEIENANQNENQNQNQNENQNQNENEMKNLEKKVTKNLAEDYSNLLKENSFKDFSIFVENKSNPFEFKVHKSILSSRSPFFHGFLQGTKRTEDIFLRQFNKKEMKSILSYIYHGDISFENQENLLQLMEISIYFQLNLLKKILEKKISNSINYSNFFQFFFQNRNLKLKEIEMKCFELINQNFSQIQKNENLFNLTKEEVIKFIQFKQEKKEIFQFDFFEFLNNWVKKRNKRLKLKKEKEKEIEKKRLFHSFFSLFDKDSISKQDFDKLNQFNNFLPNSFLIDIQNKVIQVKEKEMKEKEKKIKRRDKRIKSIKFENQKKEKENQDLKLENEQKDKENQNIKLENQKKDKENQDLKFENQKKEKENQNLKSEVEKMKKEARKLKILSDSEIVTEEEYTQKLQEWINDNNFFYKMKKGFSAKRDGFDCKKWHDICDDKGKTLVIIKTKDNFIFGGFTQVGFKQSTSGEWISDSNAFIFSLRNDKGDREPNKFTIKQGQEKYAIYYLSSSGPRFGHNGDIGLKSNLQSGYSDFGNSYNLPNGIDYNTNEAKNYLAGSFNSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAF2</accession>
    <name>A0A9Q0RAF2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_09228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5073014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAF2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="561" mass="66230" checksum="4070C526FE393322" modified="2023-09-13" version="1">MDQTFDPFEFTERSNHVSHILYGLMSFQRSQSDKTGNQKFISTLHRLLLLSKWFANCKILSGNDWIDAQIVFSRNKFKIISKSKSNFKFGYHKEDFVAQKEDNSILFIKSSTNLGQKLNFLTPRNRDLIFEFFQIITACNIANQKLQHFDEIKFPTLLSESDFLFSMVIYQWTQKESEYPIILVENDAIFHVTIKLDQKSMQIVYTDSNKPIEFQFSFNWMLYRNVMNPRRMRIHPTNQDFCEFECTSTQTRDFLLSLVSLHCKLPNTASVLRILSHENGDMQLNLNMDLFQNVNQVQHPTREKIEQVLNSVIASRFFKTHVLIFAEHRHGALTLTDSFIKLNDGEVDLFFKYETSSMLINKQNNAYILLEVHEKTKPQRIILSPKKIEEVNLILNIFFYFKLIHKHPNFIWNHDMIQEFTYQTSEKEFLQPEKTIQISRLLSRNLTTTVTITTKQIEEMQEKQKQLIKKINLRLFSRTSPVTEIDAKALIYTDSEILSVYKSKQQILRVQITKDLKIGHEFVNQRNVLTISVPNSFVLKIFDRTSDWEVLYEAIQSQLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAJ5</accession>
    <name>A0A9Q0RAJ5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin heavy chain - related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAJ5"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="532"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="656" mass="77169" checksum="F7D5643E281E3F34" modified="2023-09-13" version="1">MSNFFSTFPSKLDRRISTILKADGEKQEKLITDLRDQLTDLLKYKSNTFTLQEELNKLMAEKDAEIDRLNKSTQDLSLLNSRLRDERNQVQDQAKNMQKQFDEIQKEISNSQIMSSNLQKEYEKLQREHRALKRSFQKQLQENKKLADDAEQKEQLIIHLNSQNQLLENEKRSLENENRKNFNDKIQLNNDLSIIQEMFKHILSGDQRKTNRNLENDLGIAQKQINELKSTESFLSSQISTKEKENQKLMQGIHILVRALIPLQEKIRSLSTQKQYYQIIEKELEKYKDMVRDLKYQLTGRRYSGFESKPVSLRNFALVALFGKKLFKSIKTNNRKIGNQFFVEGSIDKIHLAPQDYSLKGFPFSLIRTEGNYPINETLDVENFVSLITYYYPNFFVKPISVQKAHQLGIDPSTYETLFFSVEPHSPSDKILFSVKNNIGQLMNQLRKEQEEKILLVGKIDDLKQDNTRKNDDILNLEDSLRKSSDLSRRLQMEVDQLQEQRKSLVPISQLNRVQDELESQKMQNNLTANLLQKAQKDVDDKATELQNLSMMLNESNKEKRRLNRLINQTDKENETLKDSITHLQQQLNETESLADFNKTEIKRLNSLLQDLQEKNDSLNLQHNQLRREISAYKKHILMLKKEIQTLIEKDVDFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAU8</accession>
    <name>A0A9Q0RAU8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAU8"/>
    <dbReference type="OMA" id="WISKRVP"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="381"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="436" mass="49331" checksum="48B5853C5AA9B0B1" modified="2023-09-13" version="1">MQIFVKTLTGKTITLEVDPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLNDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVDPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLNDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVDPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLNDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVDPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLNDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVDPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLNDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVDPSDTIENVKAKIQDKEGIPPDQQRLDFCRKTIRRWKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBG4</accession>
    <name>A0A9Q0RBG4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lish domain-containing protein fopnl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_00784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10692942at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5074156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1348" mass="159280" checksum="D53BF8C374985F35" modified="2023-09-13" version="1">MDLSKLLTFSEELLGRSIDFNNFSDIVQSSCLILNKIFPKSIPERVLKRNPTTQIQFLNRVCSNLGIPSENFLPAQIQEDIQSKFLNLVSQFYKIADQKGIDIGHESKAKIDDKLHKKAQRTIPSVFNHAEVIDQIETIKEFQFENEENQENTDSNWKKKDEEIENQMENFSQLKMVFGESKEMKPKQNREKYFITSFKRSFEEIVEIVKKHFIHGKAKFGVVFIDPQTGSQAECIFEIKRRYFKFSFTGSSFEMILDYSIRTQIWEAKSTTNIIEIKGVNFDDFLHNFYIKARDQSERDIIINTFRMFNFYQKDCIESCILSTKILGKEQEIETLIGYHVEKQSANFDVKLKMLSLTKTNIPAVLKADKHQISFVFKTAKQTQIQSYDFKRYLIMLFIDPSKQTQITLKIENMQLKAERLIQMRTNSAAQSVVISGVLNHFASLSWNSLLNESEPSQQPYSQYSHKTQANVSSRTNLHNPINYGQTIFKFIQMPSINSTFADPTFISHFAQFTKNGEAKVIQDQLFSPVNDDKRLNCEMLRYYKFRSRKNQLVRKIKQFISQGKAVFNFKLQQSRTSNIQIILMANHFVIKVESQNHTKNYKMEYLPNQGIILHTNKLDRMIFKLESSDIENLALFVPNFISRDLFVNTFSIFHKMKIYPDFHLDDDDNSVQNMHFILSPEPSLSIEKRKKFLREDPSVEFPSKWKYSEINDFFQDEKNFSEELSSIKTHLIYSVWLLNSFQKIEGLCKFHLYSDHFEIVCSNFSIRRYYSSFSQFCDSDIRDLVIRFNIDENFFVYFGFPSYEARLNVILNFNKRRDNQLQFLSIHQAQNQVSTFICHLFIANQKKLCSIQLCVGGFVINSFNKDHENDENDPNHKLIFNKENGQVLFLEYSISLTLQRKPENPRILFIGLGYGKFIKLKFAEAQILEDFTIQLNDRIRSTWELFKPNSVRNAFDEPVLEKISTDSKDLGRTLISVHPQKIVIQTGEYQGTCLRIGEIRSVLLENPIFAMNLFADQSTENIGDYDYYQIHFRHLKTRLQFIDSMIFYDSKREDFKKMFANHLFRYQVKAQVVVYEDSGNPYAQGTIYISEERGSIVLSSLDEEMEEKSSGNLNKKLNHKQIVAFHKNHYIFDKHTKFYVDLKLSRFGKLEVDQVDFIVFFQSEKEMKMFNRLFVMFKRKLAKMEVGNRLLLDSKPQDSQIQARIVVSEQETLPVHLSFRKKQLVIYHYDTDNQEEIEFTKNFEISTAKRSKFHFWIHDVHFDYIFQFYNRSDYRLAFQKFQNISQFVTQTNFEVEFVTSQKRKVPGFIRLRTYYFVCLIEISQEQIKRIRIPYHLLSIRKYSSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RBQ1</accession>
    <name>A0A9Q0RBQ1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RBQ1"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="266"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="448" mass="51842" checksum="AF8CA2259BBAFCEF" modified="2023-09-13" version="1">MNEIIFFGSNQYPILFKNEPDEIKKPIQFKFENENENENEKQIKQISSGNFGTILLFKNGKAIEYLNQEDSKQNPSKIQIEENIQKVTVGYRNEAILTIEGNVFAKGKDINPNNPNEFINISSLIEDKNDRIIQDVVCSRFSIYLLTSNQNAYGIGSNHWGQLGFDTETLKETEKPILMMKNVSKIFSGNSSYSVFLLNSNQELFGCGNNYYGQLGLGKSKRKKLKIKKLTKIQNIPKGKIIDIQCGRYHSIMLIENENENQNPKRKLYSCGRYEYNGLGKNGDIDELTEIKSSLFENDNNILDFSVGYQHTLVLTSNTKLIVFGNNYYGQLGTGDTNDQSIPIQIELPELRFNEDISNYHISCGYEKSFIYYSPFLSSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNENQNQNLKNFKKLFQKNQLKNQIRYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCE8</accession>
    <name>A0A9Q0RCE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCE8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="495" mass="57539" checksum="C0FE6908E9917815" modified="2023-09-13" version="1">MNEIIFFGANELPKLIKNEPNQITKIIQFKFENENENENENENENENENENENDSTILLFKNGKAIEYLSENDSNQNPVKIQIEEDIQKVTFGCRDEAILTIEGNVFAKGININPKHPNKFINISSLIEDKNDRVIEDIVSGAHSIYLLTSNQNAYGIGLNYYDKLGFGYETLHKTEKPILMMKNVSKIFSGDASRSVFLLNSNQELFGCGFNQYGQLGLGKSRRKEFEINKLTKIQNIPKGKIIDIQCGSWNSIMLIENENENPKRKLYSTGHYLFNGLGKDEDIYEFTEIKSSLFENDDDIVDFSVGDYHTLILTSKSKLIGFGKNEYGQLGTIDKKDQFIPIQIEFPKLRFNEDISNYRVSCEECKSFLYYSPPSFSNLEEDLINLFERKEFCDISFKTENEEIIKAHKLILKYRLNQNQNQNQIEKLKEIISKKTIKESNQIFEMIYSNNSKINPKLYSEIKEIINYNGHFSGSFARKFFLKFVYRKNFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD68</accession>
    <name>A0A9Q0RD68_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Syntaxin-132</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_07268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD68"/>
    <dbReference type="OMA" id="VWRRYEI"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000008">
        <property type="entry name" value="Syntaxin 132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5075298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="295" mass="34491" checksum="9605355ECC7603DC" modified="2023-09-13" version="1">MQDRFNKRNSNKNDDEIKLKILDDPSQNFEDKIEDYFSQVKLVEESISAIETQTKLFEKTQLNSINSTKSSESKHYAQKSSIIVQEIYQKAKIVKKTLQEMDNLNNLYIQKNGQITEARIRKNQHQALVKNFMDAMKNFQQLQQKYQTKFKEELSRRYKIVDPNISETQIEDYIENQDGSQIFSVVDTQAYQEARSVLEEIEIKHSEIINLEKSVNEIHQLFVDMATLVEFQGKNIDNIENNVIQSADYIEQGVEQLQKARVYQKKSRKKLCFIICLILTVLIIISISFGVVFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDA4</accession>
    <name>A0A9Q0RDA4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDA4"/>
    <dbReference type="OMA" id="ACQYQSF"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="300"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="572"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="661" mass="76757" checksum="555849E44AA605F3" modified="2023-09-13" version="1">MDIREIIQKNNIQLLKELKTIPINHLGGNREPILNFAIEKQVSKEIIEFLIAKGATPNSVDKYNRNSLHIAIKNKSPIQIINLLVEKGVDINAKTKKRETPLHFACEYNSRIEIIKILVEKKVNINAQAYKMKTPLHFVFQSKRKNSHEMVKYLIEKGASIDSINRKSETLLHLSCKYNSFEITKFLIENRADIELKDYQSNSPIHISCKNNSFKIVDLLIKNGVDIDSRNKGKKTALHIAFKNGFTEILKLLIEKGANINLKDNQDETILHYACKSNLSLEIIEYLIEKGADINLKNKDEDTPLHFLSKSEQKENLFEIIKFLIEKGADINIKNIDGQNPLHLACQYQSFEIIEYFISKGIDINSKNKFDENPLHLACQYQSFEIIEYFISKGIDINSKNKFDENPLHLACQYQSFEIIKYLIYKGIDINPKNKFGQTPLHFASQYNSFEIIKYLIYKGIDVNAKSKFGQTPLHFASQYNSFEVIKFLVENGAEINIQNEYNETSLHLVCQYNSFQIIKFLVEKGANVNSKIIRSMIYPLDLVCQYQHHKLLEIIKSIVEKNADINNKDSQNRTPLHKLCRYQNDENSFEVIKYLIENGADVNALTYNQESPLHLICEYQQNQNSFEIIKFLFQKVLILIVKRKQESKLLYIWPVNFKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDD0</accession>
    <name>A0A9Q0RDD0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Import receptor subunit tom7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDD0"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5076466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="78" mass="8951" checksum="E1DC791FD5D2CD7C" modified="2023-09-13" version="1">MEKENSTSFSVWDTIFDTVSKIQEKTQKQIEVIDKITQKTVSVAKPVIHYGFIPFVIYLGSKSNPPPNWFSLFPSENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDK6</accession>
    <name>A0A9Q0RDK6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional activator hac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_00023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDK6"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="221"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5076706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="304" mass="35950" checksum="98789B0559A86B62" modified="2023-09-13" version="1">MDYFRSVPKNKRVKFSLKKTNKQKKNNNKRIKNIESFKNQVLDKSIKVMDPLSDNYFDNFISDSNFGIDFGIDIDNFSKNFGNQEYPSFESIESLKNFANDFTTQLEENTIFTPFSSDKEMLSKFDDYNISIENESNKNKVKNESNKNKVENESNKNQVENESNKNKVENESNKNQVENESNKNKVEKINLKEKKPKSQAKKIVPKQRKKRKSKNSKISKEEQRKIKLERNRINAKKSRERKKIYIENLENEVTVLRDDKKSLTEKLEHLNTQNEQLQSEVQELRNLLQQFSNDETLEIPSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE25</accession>
    <name>A0A9Q0RE25_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cilia- and flagella-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE25"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="35"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="223" mass="25561" checksum="4BC8C284FA4DDE93" modified="2023-09-13" version="1">MSRISPQTRALLLRISYNKDIQYLKQNDQEEIKKVSTTDLLIRWTNLLTQSSITDISQLSDCLILGKLIAYLTETSLNKQLQTEQSLQKRASIFFDLLKNAGLKAVFSAEDLTNGNENEILKILAQMFLWKSGLPLKERPKTPTEQSAEKKSNIQDILSRIKQKSKSPINQMISHKETKTETTQNEETQTKSNSKAKISNFHLSKRNSNKKKSIAFSNFIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE87</accession>
    <name>A0A9Q0RE87_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE87"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="264"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="619" mass="72424" checksum="E8B73C5EFBE7F05F" modified="2023-09-13" version="1">MNEILFFGRNIKPKFIKNKPQKIIKPIQFKFENENENENEKQIKQISSKDYSTIFLFENGKAIEYLKYSKQNPSKIQIKENIQKVTIGDQNQAILTIEGNVFAKGRYINPKKKTGFINISSLIEDTNDRIIQDIVSGRDSIYLLTSNQNAYGIGDNYYNQLGFDSVTLKETQKPILMMKNVSKIFSGNSSQHVFLLNSNQELFGCGGNEYDQLGLGESRKEETKIQKLTKIQNIPKGKIIDIQCGNIHSIMLIENEDENQNPKRKLYSCGYSGYNGLGKDENIYEFTEIKSSLFENDDNILDFSVGNFHTLILTSNSKLIGFGYNYFGQLGNGDKNEQLIPIQIELPKLRFNEDISNYHVYCGFHNSFLYYSYPSFSNLEEDLIKLFKRKEFCDISFKTKNGEIIEAHKLILKYRLKDENQNEIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQILEYWIYSNQIKEDIQITQEIIDEIQTGIDYFQLNQTNPNLFDLLIIKKKLIKSKLKSKSKLKKLKIKIKIKIKKFKIKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RE90</accession>
    <name>A0A9Q0RE90_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sec7/BIG1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RE90"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sec7/BIG1-like C-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="193" mass="23161" checksum="39983D45926504B4" modified="2023-09-13" version="1">MKIKIKNQLKNQLKNQNKIYSIQIKFIAQLNLIQAANDLIYSGADKLNSQNIIKLLEKIKESYKSAKAFNKNIPFRIELYRSGIIINKTQQENQSNNFPNLYQQEITSIQTYLNILNSFYLKKKTIGNFDQSLIESIIFKNFSKIWEKQYKRICDLDLYFQKIDQIKHKKNQEKKIEEKMNYKNINKRLIWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REK3</accession>
    <name>A0A9Q0REK3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_00085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REK3"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="482"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="903" mass="107261" checksum="44F9DC9B858D25E2" modified="2023-09-13" version="1">MIARPIKLKGVNLIQTILIQNIDLIKDKKEEEEIIIKKIENHWENLNKLHESEDSDNDIFQEILLDEQFLNIDDIDFNFIQTPKRTHTNPFDFSPISPHKSPTKDSKMDLVEFNLYKSNKSLSYNEEDSSNKSDSSDNFKNIEKEYNELNKKYQELIKNDQVQKSSKHEELLFKLKTQTSENNEMRNVIHQKQAELDQMKREFEDIQQKIVEQKMEHEIAMDEISKQTNMDNDSLIEDEKEILDLIKEKEILIQEFQLEKEEEQKIQSEIESIQSFLQNEKANSESSILSETKELEESIQQKTQEYEDLFNLFPKFDIETKKEKVPDFIPLLQSQIEQRNQLLNKLQIEKEKANQENLIYQKKLEQYSSLGKKYQEVLNENENLRHEQKKLQKMIFQIHNESLPFISKEYSDVDLSDSTTDQGSEIEEFDPKKRKNMESNPYRIRRSGSLKDNLIQVESPLKENEKYDKFFSKILKDEPIEILQELLKIPLAIFYFREFLSSQFSTENLSFYLEVNKFKQIIDESDLFSSAELIYERFIEPDSIFEINIQLSEREEITKLIQEKKTTNSMFDSIQQFVLKKLTEETFQPFKNSKLYNSLMIDLSSDQQILSSRIITAKLDLNKSQKSLPLNLDSEFQKTPREAFALSVDLFSVLIELINTYYSISSEEINCELLSHSISFRRFSVQTLELQKVDIENITQEERFLFFINIYNTLFLHSIISKGLPYDKSTKRKFLTENKYSISGYEFSLLDIHDGILHGDRKSKSKNFMGGDKYFKQNDAREKFVIHMKDHRFLFALLSLTDKHIPLQVYRLEDYQKELSETVKVYLFHHVKIDHKQKRIILPRLFRSYSSDFGKSKSEMIQWISSWLKDTEFESKVPISNYMIKYDSQHKIAPSIIIRNRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REX8</accession>
    <name>A0A9Q0REX8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Brca1-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REX8"/>
    <dbReference type="OMA" id="ENQRVWD"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="4">
        <location>
            <begin position="300"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="492"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5077637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="618" mass="71462" checksum="338541A7CE5EB5FC" modified="2023-09-13" version="1">MFSILFEVSDQTFQINRSLNQQIEKFSNDFFGNGNGNSINLSIKTTEEENSKIIRNLKKSKEFSVEKMSENPIISIPKGTIRLFQKLNDADKDTNHLNEDSSQNLNEDSNKNLIEDSSQHLIEDSNKNLIEDSSQHLIEDSSQNLIEDSNKNLIEDSSQNLIEDSNKNLIEDSNKNLIEDSSQNLVEDSSQNSSENSNQQKVVCVLGIPSKFSPQNFFKKISNHFSNISKIRILQDSKTYRYVVIIRFKTSEFANLFITEFNETTFGLNFKEKMIAILISNVGFIDSSLIKSSTLSVELPTCPVCFSRLDSKITGLSNQEVNIGNEEWIGNDCFACQCLKNNIPIQCRACGKTEKLWICLICGEVGCGRYIGAHAQEHYEKSGHSFALDMELQRIWNYRNDCFVHKANVEQKNRNNLLQKKTAFIQNHPNATNEALLLYEFYQNDEDDFYSAKLASRSEAIQTEYNHVLTIQLKTQQKLYEEELNSFRQKIEKEYLDSIDLLMKENIELENQVNRIEQEIKKTEENKTTISKENDVLIEKQKEFNTLKKNKETEMENLVIQKNKEIHDLEDQIKDINFFMNTQQEVQKSKKKNEIQSGSIVVSAVKKQNKRRNNRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REY5</accession>
    <name>A0A9Q0REY5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dedicator of cytokinesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_06478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="8">
        <location>
            <begin position="503"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="9">
        <location>
            <begin position="1352"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5076199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1767" mass="208315" checksum="17FA23DAE3D74656" modified="2023-09-13" version="1">MTEWEITNQYGVALYDFIAQEKQQLSIKFGEYLIIKEKNEEWFRVKEILTKKHGIVPQCYIKVLEGEPPTKEILAENNYPGFIEATPAMIESEDTLIEWKYLMKDLCFFKKDFVAFEIAKTQIYTLLKYRQNLLQNQNISFSSQQILRNKLIEVIENGRKTMNLPLLPRMNNEKIATEKDVGIVKLFDLHSSLNSQKESSDLTLISSQKQDVVADLFQFLFEFNMAIVPIGSDAELHFFLYSQKSDKVLSESYVIPISRTGMHEDINKHGTLKTIFRDISKEDLNGGLYLVCKIIKYGVLLVDEKIQKKYSKVTPREYRKPFGAGIFQLPLIHTTKQAKQESTIKIFTCTNDIHFFKIHKMIINEEQSMKPVPSPGVSFTWSIFAGDYDTVLKEQEEIENSEEENQVNENQNQNQNENQNQIQNENQNQNQNENQNQNQNENQNQIQNENQNQIQNENQNQNQNQNNQNNQSNTEESKKMRFRDISFTLLTKLPEIILPSYIRNDLYIEITGGEFVQERKRTPRNIELRISLRLNDFTFQKDFIKEGLSFGTSSDFMETYKSYVFYHKNNPQWKETLKITMPSEMFANSHLYIEVIHCTTNENHDNKTFAFGFLKFFDKDNFIPQGELTINTFRYNPKLVQDEPNFYMQPPGPETTKKLIARKETISFNINLCSTILTQDSNVTQLFNWKKHPLPKILQDMTISPPYEIIKCFREILDTLFIILGQQSNNFEQKMKITQSIEYVIGIVVDKRFKHYSGVLNDYIRTRFHVSQENQGNDEKIMKAYGELQRSLCKTYTHFIEVLTKKLENIAEQDRTSLLLSMRAIEYTFRFIIYSWSYNIKEHPQEKSNQPQFKKNIQKILSQIRQLLSLKEPVWINAVQAMALRHFKNIFSILGNDFTLDELTQEIKLMIESVRKEDQKNLNQTKLEFIASLLKAGIFQTKKSRSIIIPVILNEIQFHTRKSEEESELCLQIIIILLENINKIACEKPNNSNENIQGRFFGKNKYCRVYGTFFIASIYFQIVAEARKSRQISKELVKLKEKTKLKTTQYNNQEKKISQKEIQVIKQKRTESKIKLFNSLIQIFYMIDSSQMENLYINFSKNPATRLFFFFETFTNFLEFHKMNLFQDPKDFHMKLIHYRIIFKTLSIISHIMRSKITGGMFNLKIWELYFQNIIELIKSENLQLEKKTYLEQYKIMETMGDLRLVSIALFNKNWNSITGHRFELVSVLAEECLSLVLFSNEKLKQFGIEIFYSMLISEIEKTDGFSLIEQCTIDKIDQFIREGKDQQFKDYFFIEIEKKFGENKKHQEKCNQFVQSLNHLIHQISKLKDYPQSEKFQEERAIVLLALMDYLKKTRRYGMYSKYAHLLAELYQAFGYETEAGLVLMEVNKIIAFNDDKFEEKLTEGSFNYPRETYTERKERILHNAVDLFDKGKFWENGIQLLDILRDHYELKTFDYAKLSSIIRTKSEMFRRIASSDRFFASYFLVGYYGNGFNSEIYLQFKDKEFVYRGKELEQLSVFIERMKSKFPEAQVISKEPDLSMKNSEGKFLLIASLTPSTIEEIEEKEITFPSKMNTKIRKFYENNQINVFKFSKPFRKTDKKSDNEFKDLWLRTTYLLTEEKFPTIKHSIVVSKKIIQEIPPIINAIQSVEQKNSELKEIIEKYKNTKDPNINPFSMALNGVIDAAVNGGVFKYQDAFFNPQFLKEDHKNPIHVSKLKNCLKEQQSILDDGILLHSKICPPPMKPFHDKLQTFLQKMKELLLPSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFG6</accession>
    <name>A0A9Q0RFG6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFG6"/>
    <dbReference type="OrthoDB" id="8919184at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="709"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="815" mass="94333" checksum="5EC629F32458FF22" modified="2023-09-13" version="1">MKNEKNNRELALFCQNQDENAFELIKTSISKGANVNSKQKYQKKTPLHYVCQSQNPKSIEIVEFLVSKGANINAKDFLQETPLFTASKNYTMQSMQILEFLVSKGADVNAKNKYHETPLHFACRSSAQGSTEIIQFLVSKGADVNAKTKNKETPLHFVCQSQNDKTFSILEFLISKGADVNAKTKNNEWAPLHFVCQNNNDYLFELIKFFVSKKADVNVKNDKHETPLHLVCQIQNKNSFEIIQFLVENGADVNSTTIYNETILHLICQYQNENLFEIIQFLVSKGADVNIKTKNTEKTALHYICQQKQENIFEIIQFLVSKGADVNSKTNDQETPLHLICQNPNEKAYEIIKYLVPKTTEINSKTKFQRETPLHLVCQYQKNNLFEIINFLVENGADVLAKTKDKQATPLHFICQNSNDNLFEIVKFFISKGTDFLGKTKEKKESLLHLIFQYQRNQNTLELVKFLVEKGISVNDKSTYGYSPLHFACYNPNSIQLFKFLIANGADIHANAKNNNTPFSIAIQNKNYNAMVVLLMNDSNILQLLDQQTEIPNQLAKLISQIYSINQDLHSLLHSEDNFSDWQIKSMDSSSFNVHKFILLLRFDNDHSLLDNFSQICKQKTKEEVQLALNFIYSGFADFGKFQEFFSISDDSKNLHGIGKEIQKQKENETKIKEFFQEMGFDSQWIESKKGRRGILKDLEKLYHENETKDFTIIVSEEKEIKVHKLILIIRSDLFKGMFLNVQDSSNQVHDYSGKSFETINQFIYFLYHDDFDEENKMNEKMIEEFEDVKDYYQLNESSIIDLFLDDLKSTKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RFG9</accession>
    <name>A0A9Q0RFG9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate formate-lyase activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RFG9"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="146"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="363" mass="42704" checksum="F0C4B95A0CCADAAF" modified="2023-09-13" version="1">MESIFPDPFNISNTDYYLINKQKKNPQYFEAFQFFGEENIEITEETPIEKLWEYHKTLLSKYHESRKKREVNEKEKEKEKAVKNTSLLDIKCKIAQKILHKCIFCENRCEVNRSTKIGKCNVQETRINSIFVHYGEEPEIIPSLTVFFTGCNLRCVHCQNWDLLNGKSGTLYTPRELAKAISNFVKRNSKIKNVNFVGGEPTPHLSFILDCLKELSNIYIEDPNLKKIPSIWNSNMYYSEEASELLDGALDFFLADLKYGNDKCAFKVSKRRRYTQIVHRNLLKCNQHADLLIRHLVLPGHVECCSKLCANWCFENLGKSVRYNLMFQYRPEHKATDIEEMARKLTDSEKVFSNKTYKRIWFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG71</accession>
    <name>A0A9Q0RG71_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tbc1 domain family member 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG71"/>
    <dbReference type="OMA" id="DPGPKKC"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="115"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5078448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="390" mass="46268" checksum="4F7035DA160CFF2E" modified="2023-09-13" version="1">MQNKIKMQNKIKMKMGNLNQNKKQNTNQNEIEDQNQNQNQNQNQNQNQNQNENQNEKNEKNENEEKKLQKIEKQKIQREKFMHNARKTWLKLIEQWKNKPKYRPQRKLKKLCWKGIPPSVRGKVWPYLIGNGLNITLELYQVLKQRSKASLNHLDKTKQEEKQLYQEDSNQVLNQIQEIDQKIIFSEESKFTTFFGKEKTISLITFDLSRTFPSLKIFGLEGEMRDMLSEILGAYAFYRPDFGYVQGMSLLAGILLLNMDEYTAFRCLANILNSEILIGFYGVNEKLIQHRSLVFDHFLESINPKVYKYLITQKIETKMFLFDWLLTLFSSVFSLDIACRIWDVYFLEGEVFLYRVSFAFLALIEEQLLSLPFEKAFKLLLGHIEVKNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG87</accession>
    <name>A0A9Q0RG87_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG87"/>
    <dbReference type="OMA" id="QLAKFTI"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040498274" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5078957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="414" mass="48299" checksum="6F7912296F55908F" modified="2023-09-13" version="1">MKKITIYSTILFLFLITKTKTKTETKDVIELNYLNFDSIVLKNYDQDVFVVFAAEWCPHCQKLMPEWNKAASTLKGLIIFGHVDSSDQVLNQKYQIKGFPTIKLFKHTKEGGVKEVIDYNGQREFNSLKNFALSFLESYVVDLQNVDQWISSTQDRKKVVLFPSSKFNDVPPLFKGLSRDFRGDLGFGVVFQNNPDHKYLMQMFGVDNSPKIVILDKNGSPISYYSGKTEYKQLKKYLSSFVSSTSENFENFENENEQENEQENQENQENQKNQNFIHQMTNQNYQDICFLQKKGLCVILTLSEFNKNQNEEEKISLFEQMMIKLRKDPLFKSFSYINFLESDIDNSNDFMENLGDITDLSKNHELFVINPKKSKMVVFEGKLEDELEVYNFLDHIISGEGKFISLNKNQKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGK4</accession>
    <name>A0A9Q0RGK4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGK4"/>
    <dbReference type="OMA" id="ILRPTHE"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="571" mass="66399" checksum="B3B9C9E5EF2E9933" modified="2023-09-13" version="1">MLSSVEGFKILLLDDKTTQFISILFSQTEILGKEVFLVDKINKSRREEIKHLQAIFFIQPTNENIEILDSELSEPKYAGYHLFFSNILNQNQLGSLAHSDKHRIVKQVQEFYIDYLAINESLFQFNIPKISHIFNSSLENDPLIDSLADRILSVLLSLQTRPNIRFQTPYKTTQILAQKIESKIRKQNQLFDFSRKDQGSILLILDRRSDPLTPLLNQWTYQAMLHEFFGIKSNIISLKHLTGIRKDMEEIVLSPKEDHFYHENMFKNFGDLGDSMKNLVDDFSKKYKITQNIQSIEEMKAFISKYSEFRSSSISVSKHVTLVSEMSRQIEANSLFKVSEIEQDLAVSQQQKKHFSQISEMLENRQISDKDALRLALIYSLRYHQNTQNIFTLLSLLGNRGLPERDLALLSQIQKFFHSQKSSEDIFHNKSFFTSTKHAIKRKLQDIDNVFTQHSPLISDIVSRLQSNTLSEKNYPFLLINPKKSQSSFKTLIIFIIGGATYHEAATIHMSNLQLDQNFLNSNSNFNSKNQNDNSFFNFSKLEKNQNFQIILGSNFIHNFSSFLDEIHNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH38</accession>
    <name>A0A9Q0RH38_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_04170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH38"/>
    <dbReference type="OMA" id="MARQYRF"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14017">
        <property type="entry name" value="STKc_TTBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047916">
        <property type="entry name" value="TTBK_Asator-like_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5079857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="420" mass="48516" checksum="3396BE4FD2164C97" modified="2023-09-13" version="1">MLGKLIRNRWVIQKKIGQGAFGEIFVARDLELQENVAIKMEKCDQKRETIKLEALVLKKLQGSPYAPKYISCGRYEDFNFLVMELLGQNISQLKRSLPDSKMSLQCVLKLGIEMISSIEDIHSIGFVHRDIKPSNFVLRRKKSENKSVCCILDFGLARKYVDADFSVKPPRSNVGFRGTARYASINSHEARDLGRCDDLWSLFYMLVELLVDDLPWKKLKDKEEIKTLKIIHNEPKFCQDLPEGFLKFFEHVRSLGFEDEPNYSYLRQILRDIYISNKFDETIPTELDMSFEQLTLNSPKTLTLDSNPAHLAMTNSFGKSFSPKLTREFSRLSEIKLNQNDNQDPQSGKLRNSLSLNHMAGEIFLKPNSINQPNKFNNFDRIQTFSPDNEIELDPIKPKFDDETETDEISEKKCKCCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L648</accession>
    <name>A0A9Q0L648_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_03065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L648"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5066721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="159" mass="19369" checksum="59F37A3BEE8A6326" modified="2023-09-13" version="1">MIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILMMRSELYRGMFLSVTEDTSNKVTDYSELSEESFQIFEYWIYSNQIKEDIQITQEIINEIETGIDYFQLNQTNPNLFDLLIKKFKNQSIREKLDILYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L795</accession>
    <name>A0A9Q0L795_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_13038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L795"/>
    <dbReference type="OMA" id="PHEIMTE"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000956">
        <property type="entry name" value="CAMK family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="326" mass="37167" checksum="F5827EF72D9E3CD1" modified="2023-09-13" version="1">MQSSIGKYIIQRTIGEGSTSKVKLAIEPETGKEVAIKIIPKNKVTAKSTTLIRSEREIAILKLFNHPNIVKIFEVFESDEYLFLVMEYMQKGELLDYLISKKAISTTQSLFFFQQIIYAVEYSHSHLISHRDLKLENILLDSFGNVKIVDFGMAGLVDNQNLLNTSCGSPHYVAPEVVTGKSYDPFKADIWSCGIILYVLLVGRLPFDADSIQEVLIQITQNEPEIPSHLSPDKSQLLQGMLQKDPQKRMTIQEIKENPWFCSNFPRYFEQPKTQIDPNFFSPRKVENLSTSIISSLSRLGIDENSIIEFLTSQEANWVKVFYSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7B8</accession>
    <name>A0A9Q0L7B8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000143">
        <property type="protein sequence ID" value="KAJ5066413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7B8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="962" mass="113976" checksum="AA6BE366AC0C0D98" modified="2023-09-13" version="1">MEQKYFIQVKNYENKKVKLTNQNEIIVEWKLPEQFQPKSNDKIALFDATKEKNEIYFTYKNNSNSQLEGTTFLNVNYVEIWKNKLQIRYLPENKSKSILVSEVFEIIPFEKIITIDEINEKEIKTTWKLPVNFIPNGDDGCDGYSLRRWDLICLFPKDDPFYSSYLDYVANYNATMNGTATFNTGSCMRNETNEEFVIRYIAVNEDKIAESEPFIIKSKIPENHLILSKDKFLFGESIEVSWEFPEDFEISEKSRIGLFYENSISSQYIELKYIYQTNRKDSIIFQTKDYQTINFLDNLQFRFFSCDDKSQCVSKPFQIQFLENNGIEIIAKRPTFEKHNDRVSRIGMIEFKLDDDLKKENTNENEAQLFIVKYISHLKTSNEKKYCLLLLIFGVDEFKIFKLLVSKNEIKYGESIDVKWEFPEYYQSNERDWIGLFLKDSPINNSLKKIKYLNLDIIQKDQKNPIAKSEEIKVKEFDKKNFKLLVSKNEIKFGESINVEWEFPEYYHSNEQDWIGLFLKDSPINNSLFRKFTSNLAKKGIFTLDIGNYITEENQIFEIRYYPKDQKNPIAKSEEIKVKEVNKKDFKLLVSKNEIKFGESIDVEWELPEYYQPIHGDRIVLFLKYPRIDYNSLIIKDNSNLARKGKFTFDINEYIKDENQIFEFRYIKFYGRISLMKSEEIKVKEINRKDFKLSVSKNEIKFGELIDVEWEIPEYHQTNYFGRIALFLKDSTTTPGLTYQNIPMHKKKGKLTFDIGNYITEENQIFEFRYYPSEYKYKPFAKSEEIKVLPLEGGIIKSSPEKTKIGETIKVSWELSNNYEPHQNDQIILFKSQLQSKEKEAPKYFQVYYKNEKCEKKGEVEIKIQIGGGMIEEEFIIGYYSYSYSKIILCQSPIIIEPTSFFITPLETDRFVILSTKNSKFISIISSNLLYNISLSHSGISELSTNQIKEKDIMQDFCNWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L7P9</accession>
    <name>A0A9Q0L7P9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
            <shortName evidence="7">SRP14</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_12829</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L7P9"/>
    <dbReference type="OMA" id="RFNGHNK"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="129" mass="15231" checksum="23E9096B2B7F6B23" modified="2023-09-13" version="1">MLLKYQEFLRQLAILFQKNQKKGSVFITFKRTNGVAPHKKKNENKKNETHEYFCLIRATDGEKKISTHIHQRDIVSFQISYAGLIKENMSSLKKKIKNKNKKPRKKRSKKKIQTQLAKNSNELNTNEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8G9</accession>
    <name>A0A9Q0L8G9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_02970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8G9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="328"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="500"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="607" mass="71159" checksum="95C47B949A521688" modified="2023-09-13" version="1">MNDCLFFGYNKYPKLIKNEPDSITKPIQFKFENENENLNENENENENENEKQIKQISTGEYSIIFLFKNGKAIEYLKGNDSNQNPEKIQIENIQKLTVGYANEAILTIEGNVFAKGIDINSNNPKEFINISSLIEDINDRTIQDIVSGYSSIYLLTSNQNAYGIGSNYSTQLGFDSKTIRKTEKPILMMKNVSKIFSGNESTCVFLLNSNQELFGCGWNYWGQLGLEKSRKEDAYIDKLTKIQNIPKGKIIDIQCGYWHSVMMIENEDQNPKRKLYSCGDYRYNGLGKNEYTYEFTEIKSSLFEENENDNILDFSVGNEHTLILTSKGKLFGFGNNEFGQLGTGDTNHQLFPIQIEFLELRFNEDTFNYHVYCGYKSSFLYYSFSSFSNLEEDLIKLFRRKEFCDISFKTENGEIIKAHKLILKYRLNQNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNKIINPKLYSEIKEIINSNEKIEETMKRIYGNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNKIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNIQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9W8</accession>
    <name>A0A9Q0L9W8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cerebellar degeneration-related antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000110">
        <property type="protein sequence ID" value="KAJ5069002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9W8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="503" mass="58513" checksum="936EF7098FE84743" modified="2023-09-13" version="1">MLLFFSTTFIHLTYQIISKVDLNLFKSRLRNSINLFEKLIQSKYFQKWDSQHQESILGISSVLQVLIILVFFYSTHKNDTVLGLYSQQMLHAFLSKIFQQEVTHRNLTSEICAIIPWIQENKDIVFNLIKVPEEKSNFAFKHSQLKNAKSLRDMMENFVNYCSVISLDIIKEFSLYEDENDNDSDRINVEKPFSFSKQVIDIDRSLFGLRILENFHNSLLNTPVSQNKIKTCLIQEIRSEIQKEFKRTDKDNENNDFSFNSSQKISIKKKISSKTNSNSKQEYKSKQESKSKQESNSNSKQEFKSNSNSNSKQESKSNSNSNSESKSNSKQESKQESKSNSKQESKQESKSKSKQQSNSNSNSKQESKQESKSKSKQESKSKSKQESKSNSKQQYKSISNSKQESKSNSISNSNSNSNSNSNSNSNSNSNSKQESKQESKQESKSKSKFKQESKSNSNSISNSNLKFKINFKFKFKLKFKFNFKFKFRIKFKFKFKFKFKTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LB63</accession>
    <name>A0A9Q0LB63_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat and socs box containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_11853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LB63"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5069235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="133" mass="15672" checksum="514BFD829B1688B2" modified="2023-09-13" version="1">MIENKGINLNLQDKTPIHYLFENKSITKEIIKLMIENKGINLNLQDKTPLHYLYLNPSVTMEIIQFLIDKGYLQEINPVEIEKELKLLDDEFNKSYYNGATLLHYFAQKEPINKDLFNHFINSGADWNKQDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBL0</accession>
    <name>A0A9Q0LBL0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5 7">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5 7"/>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBL0"/>
    <dbReference type="OMA" id="DKWGIPT"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="183"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="242" mass="28427" checksum="8DA665BC8D23EB2F" modified="2023-09-13" version="1">MLSKISNFSSNHSVDKFVLSQNFSNFVGNFAEEEIYKRKKEMRKEIKKKLQKIKSEEIETRSKKIVEKLFEHPKFLNSKSISVFVSSKKLKEVETKEIIKKILKDGVKKCFVPRIESIEKSEMKMYRIYDEEDYQEMIAKGDKKELFEPNPFYKSKGREEAIDSKTLDLILVPGLGFDYKNHRLGRGKGFYDNYIQKCNQFYSLFSLPKPYLIGLAFAEQLVKEIPVTKNDKNLDEVITDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBU5</accession>
    <name>A0A9Q0LBU5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Activating signal cointegrator 1 complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_12263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBU5"/>
    <dbReference type="OMA" id="CLAHFQT"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="295" mass="34474" checksum="A4287877A803421D" modified="2023-09-13" version="1">METNQSELKITIQILNEIIPFIKGKNNKTKKKIEKQTNTKININSQPEYQSLIEIIGNNSNNIEIAKSQIEKIIQNSKNHLRATHFISIPLNNSTIISNMQNLEQKIQSIYQENENTECNFSPTFLQKPEKLHLSLLLFRIVYKEDLEKMKEIFKKINLENLQLKNTKISIEKLGYFSNSENLNKTRIVFAKFAKESNPNSYEKIVQLHNILASTFKEQGFSFDQSQFNPHASIIYPRYDSKSKISTFDSNPIFIQDELRNFQFGEMFLEEIHLSSRFGINPVNGYYHSEEILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC62</accession>
    <name>A0A9Q0LC62_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Specific protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000100">
        <property type="protein sequence ID" value="KAJ5069991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC62"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="120"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="274" mass="33037" checksum="C3EA33887FBF2F38" modified="2023-09-13" version="1">MFALPSLNDLEDMGFPRERAKKALELFRDFDQILNYLSQDYFPEEMESIPEKPPPKTHQKSKEFSSYHDFINEYRKRYTKDPESARTLYRSDKASPQSNSSFTNYSPNPKLNLREELIPIGLKNVGNTCFLNSLLQTYFMLPSFRNEILKFKPTQKEWEIQKKEMKLSKDDLIHFLPLDLIHEIQRLFARQLLSNYKAVDPKHAIEKVQDQNGKQFHIGNQHDVTEFNDLFWKRIEEGYFVFEDFKSWKEKEEKKKLRIKEIRKRRQKEKEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD34</accession>
    <name>A0A9Q0LD34_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD34"/>
    <dbReference type="OrthoDB" id="17763at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="260" mass="30125" checksum="98B5863ECC9525AB" modified="2023-09-13" version="1">MQENETKQRKGKETKIIEKNNKEKVEKIEKTKTQFKHAKFIRISGIVLGIYYILAIGVSRYITRGPDSIYDNWWVCNAGMVLGVIGMLTLKLQMVGGACLLIFFPSIFWCIDVVSYLVARKLPLGSASYMFKDDTPFLEIASTTHHLWYLPFALFIISLETRININSWLISNGVLTFIVVGARIFTPKYTLLPDGRNFLLNVNMAYNFWDDCPIKFMHYFDDWHPVVYLTYMNFIGYFGFHLGAFIICHPISRLISRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LD66</accession>
    <name>A0A9Q0LD66_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hepatocyte growth factor-regulated tyrosine kinase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_11066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000097">
        <property type="protein sequence ID" value="KAJ5070219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LD66"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="449"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5070219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="756" mass="88300" checksum="F51B16B299E91D99" modified="2023-09-13" version="1">MNEKNDPKTIFLYDLPFSPTHLIQSLTKSHKIFQLNPFKNTKLGFSLLLPNNWKTKKDIQEEKKEFPSWSLVGSFSAKKEKETPGIKVFTTILGFESNLVDILSLFCLYKGWKLFAFRIWKKNSFQFVIDGGALFYENDILYLARIMVFDYSKHIFLVVGICKATRWDVYKNIFLVGCSSFTFQNKSENQPIQPFQIFKGGDPFLQLKIPKNWTIEEERETPKGISAFQVELLHKEDVLGYIFVKSSLINYEKRIGFQDLLNEALEELTISGFKIYGIPIFIPGKAFLGSFALKGWVKGEQNFDPFALSIENYIGTAIIPGIIGEQIVEARLGFRYLETVACSIYLISSTQYNSNILWLLSKKAFEIIRENLWDDEDSHKNRNKYKYKYQYQNQNQNWDENLDEKIIIKLEKGLNGLGWEMISENSIISHSDCKSFGIKNLQQPKWLNDQGTKVCMNCKKKFTVRRRRHHCRHCGLIFCKKCSTKKQIIPKFHLEKPVRVCDNCFKILEEGDSFANIIINQNDQKNQKNAKSKKKIKNNFRWKNCGDGTFIELEEWIDSDVNLSTKITKTLENQSKKKVIRVEKVNSSQKENPNIEVLDLKQEEENEHIIYKLNQDKMKIGTQLINVEGRWYDCVVWKSSSLNSSQIYQWINDSIPFPIKTFKASQESYVFKEIILTKIKEELKIAKKTLICLKFEGIYQNENGEKFNDIIWVSDKVPGGIVKEQKQLANNRLLSIEMKNFKIIYPEKQEKFNSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDP6</accession>
    <name>A0A9Q0LDP6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit</fullName>
            <shortName evidence="8">Oligosaccharyl transferase 48 kDa subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_10809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000094">
        <property type="protein sequence ID" value="KAJ5070540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDP6"/>
    <dbReference type="OMA" id="AHDEYPR"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040544255" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit" evidence="8">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="287"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5070540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="430" mass="49741" checksum="31C2A275CDC60E95" modified="2023-09-13" version="1">MKNYWIFLILLNLIFISYSKPFENSKTLVLLDDLSEKYLFSNFFNFLEENGYELDFHTPNDPSLSFKKFGKFTYNQLIIFSPRFEEPTIEVSTIVDFIDDGHDVIIGLSSESSDELNNLANQCGIQLDGEGTAVIDHFSFHEPLDKSMHHTTIIAKDFIDSKVMLGKYDPKEMAPVIFKGIGMKINQESNLLFKVLTGSPSSYSFYIDESIEDEELFTVGTKTSLVLALQTRKGSRVLFSGSREMFSDEFFDSNIGSQKSGNQIFCQEISLWTFRERGYIQVKEFTHHKLGEAEPQKFYVVLETMETYISLVEWNGNEWVSFEPNDLQLEFIMLDPYVRTTMKFDEKLQLFSTSFQVPNRHGIYKLLVEYQRVGYNLIHQEEILPVTPYADQSAHQFLTCSLPYYSGSISMLVGFLLFSLLLLYYKVDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDY0</accession>
    <name>A0A9Q0LDY0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation factor tfiid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDY0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="219" mass="25025" checksum="A0EC6A3FB7076EF6" modified="2023-09-13" version="1">MEAKQIANEEQKNQKQQKYTTALDNKLHQALYSQLSTWSWGMDLQISNKITSSKKTTDLPFAKFSNKNQSSKSSFNKFYQEYILPFKGHDPLKDIYSVCVSNTGLFVLSSSQDNSHNVWNSSNRSGLFTLQGAKLSTKCNPKFSQFDDWVVCGSDNGKILFWIIDPRSQSRQDQQINVFEFLKIHKHPVSCVNLNEDNSVLVSGDLSGRINVRTSEFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LE51</accession>
    <name>A0A9Q0LE51_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LE51"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="488"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="595" mass="69870" checksum="D655B2B77D0A2D83" modified="2023-09-13" version="1">MNEIIFFGRNQKPKLIKNKQDKITKPIQFKFENENENENENENENENEKQIKQISTGDFSTIFLFKNGKVIEYLKYSKQNSEKIQIEENIQKVTVGFQNEVILTIEGNVFAQGKDINLKNSKEFINISSLIEDVNDRIIQDIVSGYSSLYLLTSNQNAYGIGSNEYGQLGLDSEILKETEKPILMMKNVSKIFSGNTSNHVFLLNSNQELFVCGWNYWGQLGLGESRKERKIQKLTQIQNIPKGKIIDIQCGYFHSIMLIENENENPKRILYSCGYYKYNGFDQDIYEFTEIKSSLFENDNILDISVGNAHTLILTSNSKLIVFGLNYCGQLGTGDTKYQSIPIQIELPKLRFNEDIFNYHVYCGFNRSFLYYSPSFFSNLEEDLIKLFERKEFCDISFKTENGEITKAHKLILKYRLKNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITQEIINEIQIGIDYFQLNETNPNLFDLLINKFNNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEB5</accession>
    <name>A0A9Q0LEB5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEB5"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5070870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="210" mass="24701" checksum="CF1CA0F811B5B771" modified="2023-09-13" version="1">MICLGCGMNFWLTHKYNINFYVLDPSYNDYMNHIYVKPYTRVLPYIIGIGCAMILISFYEKRKQNQINQNLDEKDRLINTKVYLKKSNLKTILFGYLIFIIIFVMLVIVILLPYNNYKNEGKNWNINGNAAYIGLSKLFWGIGIGGIVIIFYNYTNIFPLIRKFLSLELWTPFARLTYNAYLMHPIIMHLVNSSTRILFNYNAVPISFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG12</accession>
    <name>A0A9Q0LG12_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49473at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040475906" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1562"/>
            <end position="1584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1609" mass="175752" checksum="B1D0FEAE3617F09F" modified="2023-09-13" version="1">MLIKRTIILLLIFLFFLIQLIQSSKIKFESSGAETYVWKEVFNQFPSSTASGYGDGLAINQDTAAVGDDYGLIVYIFKYDGTNWQYIQNITGASNSRFGLNVDFSADSSVLAISSHSTSEVFIYSWSGSEYVQRDVLAGDAYSYFGIGVALSGDGNRIAVGSMKNQVEIFEYASGTWSSTKVLTKTMSFVSYGFPLAISENGEILLVGDGYDNTTFVYSYDSGQWNKIQNLTGPKGFSYALSICDDGSVFVVGTYYSNAAFIYRKNGSTYDLDKSLSDTISTTFGMTVSISEDGNEVLVGNSGASSVYVYIYQSGNWVEQPVMKPSSFAYSFGSTVAMSGNWSIVIKSFSPRGVYILEQSILTGPGIDLVNCTSLYSKFECYWTQPENDVTLQFQIDYGYGWTIIPNPSFDSSVNVFYEEFTSQDYYQIYGNEEYSIQIKACNVTTGQCGNPTTTTTLKTMIDAVKNLTLTGLSDRINTFWDPPDVQIIAGIPNLDHYIFCWGIDKSVDGCIDVPESAYSVGLSDLTCGEIYTIYVVPCRTYECIGDDEGELAYGKVQVGFGPVFDLQCLVSDVLDVHCSWLPPDSSIAPSYYNLTSQSVNLPNQYYQINVSACASNGGCGVISSFQIRIADIPHPNIISSYSGIELIQITFSQVSQAKAYLVTIDDHLSWINFSSLIPNGNEMIGTINQLDGNVEYGVAVRGCTDSSCQPQYLGDSSQTISIKAQLGNITGLNCNSSICGFDCEWNSLELSEGLQAISFWFNQNLTCLNKSSTTLSLTELLGGLNSSTSITTQKIPSPSIIQSNSKPDEIELIFTNLIQAKSYLVSIDNQQTWINFSSLIPNGEEITGLINNISGNVEYEVSIRGCSDSSCTFEYLGYSSESIPIKAQLSNITGLNVSAKSCGFECSWDSIDSPGIQAFAIIINLLLTNQQLKSIDQTQSICLDKSSTNFSISNLTGGENYEITIFASADPNCKPNDYSGLNVTFEITTEKLSAPSIIQSNSKVEEIEMIFSKLSAAKSYLVSIDNQQNWISFSSLISNESEMIGTINELDGNVEYEVSVRGCTDLICQTQNLGYPSESISIKPKLGNITGFNCNPIICGFECEWNSLELSTGLNGYSLSYGSESICLDKSSTNYSISNLIGGENYEITIFASADPNCDPNDYSGLSSIIEIETDKLSAPSIIQSNSKVEEIEMIFSKLSEAKSYLVSIDNQQNWISFSSLISSGNEVTGTINQLSGNVEYEVSIRGCSDSSCTFEYLGYPSESILIKPKLGNITGFNCNPIICGFECEWNSLELSTGLNGYSLSYGSESICLDKSSTNYSISNLIGGKKYEITIFASADTNCDPNDYSGLSSIIEIETNKLSAPSIIQSNSKVEEIEIIFSKLSEAKSYLVSIDGRMTWINFTTLIPNGNEMIGTINELDGNFEYQVSVEGCIDLICETQNLGYPSETISIKPKLGNITGFNCNPIICGFECEWNPLELSKGLSGYSLSYGSGSICVSKLMNQISIFNLIGGENYEITIFASGDWKCESNEYSGANLTTSITTIAAPTQEATESSSNTKVIIPAVIVPIVGVAIIIIIIMWIKSKSKKRNQNQNQNQNQEIELSDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LG42</accession>
    <name>A0A9Q0LG42_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-actinin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_09720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LG42"/>
    <dbReference type="OMA" id="AKYETQY"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="137"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="598"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5072076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1273" mass="149216" checksum="85428C7A2832DEDC" modified="2023-09-13" version="1">MSRTGRTTGPKSQEWVRLQRKIFSRWVKQKLLRTRPEIQVNDIVDDYKDGIVLLSLIEVLSESKFEGKYNQRPKMSVHRIDNLNNALKFAWSKGVDMKVKPSAEQLEKGDQKAALALTWGIMMKFMKIDDESGGDSLNAKDALLMWCKNKTHNYKGVEITDFKKSFADGLALCAIIHKHRPKLIDFDSLNSGDPIKTLQIAQDAAEKYFGLEKYITPDEIRKLDENSMVVYVSEYYYGIAEQRKLDLAARRIKKLIVMTKENDRLKAEYNKTAKNFKETVKKVEKILEDRTIDNTMAGAKHRLEQFYEYKANDKNTLIANQLDLESNFNNLAMRLAHHKRPEFKPEIGCSLRDIEKDMLHLEECEQERKVALHAELNRQLKLANLAIQHRSRFDKLIEYSADKQKYLEFREEISSVSAANLHLRLLDRFEKENETVINTGVANLRKLSEELVREKYENSTEIQKNDKIIDEKFKKLDELAKIKRPILDDHLKREEFIEKVRQMNDEHKDKYDQIHKWYLDKKRYLETREEINSVPDASKNLRILELYVNEFKSTCDTLVDEFMKLGKDTAAQKYETKFSGYVFNETKYQGKTFGANQLDKILQRNQEIQKFLRELENLEKTKKIILDDHLKREEFIEKARQMNAEHLDRLAHLSQWVESKEQYLNTMETINSVVEARRQLEFFGSYSNEFNKYTNGQLAEFVTLGKDLLAQHYKTEHSEYVCDETQYQGKTFNDNKLEEIQSRIDLMNSNFEKLSELAKTKKAILEDHLKRENFILNVRQMNEEHLDKHKKISEWFSSKKPTVEKLEPINSVSEAKTYLNILESYNTQYNAMVQTRVAEFKQFGAKIIAQKYSTELSQYIFDETKYQNKSFGKDSRSAIEARHTEIDSKFSELANLASKKKKYLDECLVRETKKEQLRLDFANTSAEIVAFIKLEIENASLRDFGFTLEEVEAYSSYITNSDKAVLSQANELEQNCSSLKEQMDELEVTENPYTQLTLDDVSSSMSSLKSALQNRKQAYEAELKRQRDNDALCRKFAELADPFSKWISEQKDKITISKESLENQLAFVDKSISGLSSERTKIKPLQDIQEKMDKAGIQNNRHTTLTLKDVLVQFEQYENFLKRKKKMLEEEIENQKLRGITAEQMEEIEENFKQFDFDNSGTIDRKELTACLYSLGEERTPKEITKIMEEYGDGKDISYERFKDFMIVLFGDTDTKDEIINSFILINRGFKVAKKDLMELVMDDHDINYILSTAPKVEDGYDYHTWTEEVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGE7</accession>
    <name>A0A9Q0LGE7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGE7"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="556"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="630"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="666" mass="75641" checksum="A0E5EB485434591E" modified="2023-09-13" version="1">MDLIVKAIEENDIEYLKQIESIPENEIKVGPKYKRKLILHFAIEKKVPKKILKILISKRIDPKLMDPFGRNSFHIAALKNPQKDILEFLLSKEIDINLKTIINQTALHFACKSKSISIEAIKYLVENGVDINAKTKLNETALHYVCSKENPPLEVIKYLIEKGIDINAKTVENKTALHFLCSKQNPPLEVIKYLIEKGIDINVANCLNRTALDLVYLNPKPSFEVMKFLMEKSVEKPPKIRDENLQNTFFYVFGNQNPPFEVIKNIIDIGIVIKELYQKNQAPLHYACGNPNISIDIIKYLVENGADINVKAKKDHETALHIACQYNSLEVIKYLVEKGIDINATTLYTNKNAFYYACRYNSLEVIKYFIDKGIDINSKTGRNETALHIACKYNSFAVIKYLVENGIDINAKTVDNKTALHFACKYNSLEVIKYLVEKGVDINATTGYTNKNAFSYAFQNENGSFEIIKYLFENGIYINAKAMENVTPLDVACGNKNPSFQFIKYLVEKGVDINAQTENKKESSLHIACRNPNISIQIIKYLVEKGIDINAKTKYYKETALHIACKNKNPNISIQIIKYLVEKGIDINAKTAGNETALHIVCTNENQFISLEVIKCLVENGIDINAKVYDNEAVLHLACRNSNLSTEVIHYFIEKGIDINAKTDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGH9</accession>
    <name>A0A9Q0LGH9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGH9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="120" mass="14580" checksum="1B9CA652447C37CF" modified="2023-09-13" version="1">MKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITQEIIDELETGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGT1</accession>
    <name>A0A9Q0LGT1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGT1"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF40">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="752"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="799" mass="92508" checksum="95EB30FECB880602" modified="2023-09-13" version="1">MGNSEPKDSGKEVKIKYKTNEKNEIINVDLSRIGKTKIPIEICNEIISHKPPIQILNLGFNQLSSHQIFFDLIFKLKELRVLKINNNFFSSLPKGLTENLPKLEILDISNNSLSQFDEESNFPNLTHFYARRSSLSIIPDCILNSTNIRFIDLKKNSIYELSKNFENLTNLEHINLSSNRIQKVELNLKKLSKLQTLNLAYNSISNFRISEDDENQLSEIDLSHNRFNSFPKSILSLKKIKKLDLSDNEVSIPDEIQQLTSLEILRWNSNKISTIPKNIANLKDNLKELWLRYNPFREFPKELLELKSINLLDLTGTKLKEIPDEISTQLPNLERIYLAYNQLKEIPNGLKKLQKPLKRIWLDNNPMNENDTKIVESGMKKLLNYLFPLRKEEEKEIIIENSNNSNNLDEKQEIIIENSNDSNEKNEIIIDSNEKKDIIINLDEKDEKNESFIVMPKNATKLSIEELKDKIRGTIIGNCIGDAVGLATEFLDKYTSSYNYDFEYFDYEKFLNDGHRSAWIEGDWTDDSDQMLLILDGILANKGKVIEQDFAKRLVHWIENGFREVGDSDWNGSWRYCLHLLLNRLDFWKIHIHVQKTFGKEMNKNAAANGAVMRTSVLGIPNFHDLQIVHQNALKIGKVTHYDSRCRASCIATTSAIALMLQGEDDIQKIIQKSIEFGEKEFEQKEYENESRLKAFQEYMNMKSWSELKLDEPRKIGYTLKAVGSGFFALRSLEEPEDFSQLLTEMTMEAGDADTNGAVVGALLGCRIGYSKIPEQWKRMPHLNWVNYKIDQLFKLMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LH58</accession>
    <name>A0A9Q0LH58_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btb (Poz) domain-containing 2a-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_10440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LH58"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="176"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="388" mass="44896" checksum="37F6F49EAF68F034" modified="2023-09-13" version="1">MENEMYIYPLQIPRFCQEMLDVLRGCVVADFNIVSADNVVFQVHKSIILTRIRRYGTISKMNLMSNISNEVILQGNTQENSQNNNLYFDNEDQQLNSFCNLMRRYRYSTVYSLLQYFYSGLMIGIDGAVAHEFEEIATLLKFDRLLKSVQSQSFGEIHLEELVEDLRFMLENERFTDFTVMLHNENSNQKIPIKTHKVILAARSELYRGMLTSVVDQSNSAPDLSGRQLGALLTLFLYLYTDKLNINSIEDALQLFGAYSYYGLSDSLFDRKICAYLYHNLNIDNAIQICEGLLPHWNLIPAVREFGNTILRFIHENPVLIPSWELLVQKYSFLSQEAFDLSQEVFPESIDYYNKVNLNKDENKMLQNHDNSDDSSNDSDDDVGGGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHG6</accession>
    <name>A0A9Q0LHG6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHG6"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="387"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="502"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="939"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5073431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1156" mass="135187" checksum="D1C9FC4E7F3CF74B" modified="2023-09-13" version="1">MTSPNENENENENENQNQNENQNENQNENQNENQNENQNENQNENENQNENEPIINFKMDFVDSERCVIERRIIRPNQLQNQVIQLSENEMKILQLKEFILKLLDSNYPLFCRFLKDQNGIRILPKVRANSILASKAREDLSTIFQSESWNYVRTVQLRRIYLSILRSIKKIFSGSTKHMIDLIQEKWGKIQEERLLALKEKQQFQPLFFSNIISKNKMRKKEKKKINKQYIQKLRLVQFSWKTIYRSLIHQRAPWGDSLNQITQDTHYMLDRIEDNSRRHKKLKINFVFDLHVLPPDSITEISSPSISSSKTTQQPEIELSKKILPTQTSKQPTILSENEELTTNETNETNETNETNETNEINDPNIQQIIDPNGNTSVQDLELQIQKSDVFFSVKSTILNVSRSTEGTFELSRKRIYFFVDLEKFEESKEKKPLIHTAKDKSWLVDSIVEIHHRKVNFQQTALEIFFTSRKNYLFNFQDMESRHQVYHTLLSLKPRSLRKSQDSLQNLKKITKKWRERKLSNFDYLMKLNSIAGRSYNDLSQYPIFPWILSNYTSEKIDLSDPKNYRDLSKPIGALNQTRLDILKERYENFKISTPDIPPFFYGSHYSNAAAVVYYLIRLEPFTSISFKLHGNKFDHPDRLFSSIEISWNSCLRNSADFKELVPEFYYLPEFLTNRDNFYFGKQHDGKTIGDVVLPKWAKTPEEFIRIHREALESEYVSQNLPKWIDLIFGFKQRGKEAEKAYNVFFYLTYSDSIDLNNITDPIERKMVKRQIENFGQTPPQIFGKKHPLIKPKQSRQHIPYSWTSDSFNSISGIWFEYSTSPILYITFSYRLSTESQHSIPEKLITFNWQGKLGINRWAQSEKSLTSTNNLPEKPLEIDSTLQQKKRIGVTFVDDTLNYVNCCAVSTDFNLFFSSGYWDNSFKISSIDNSNLLNNIVKHKDIVTCIAVDTGNYLVTGSRDTTIILWNIIRFGRKILVIEPRSTLYEHDDEVTCVSIHSELDIVVSGSKDGTCVIHTIRSAKYVMTIDINSIFEKENSPQKIRSQVQMVRLCSDGRILIFSTNPSKLSIFSINGKLLSYFDLEWDINSWSLTPNDEFLVVGTNEKFIAIFKVINLEHLHTYSVDYSIKSITVANDLRHIVIGSSTGDLIVFPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHU2</accession>
    <name>A0A9Q0LHU2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHU2"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="300"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="477" mass="55567" checksum="8AD69C651AA2B529" modified="2023-09-13" version="1">MDSGLFSDLETLSQNFEDLLLDENSKDFTIEIESEKPIYLRCHKAILNCRSDYFKALFRSKMIESQQGKVVLHDTSKEMMEKFLKYIYTGKIEINEENAVEILISSRKFCLDQISEFAAKFIKQRITTQNVVEVYQISNQFLCEDVADFCFKYIEDKIQLLLETDLLYSLTEQEMEKLLKSENIFITREYRLFDLLLHWAQSQIGCPISSEIDPLYLDQIQKKISHLVQFIHFSEIEKDKFLEIKSKNLLSKDMIDKIEELHLQMDRETNQDPNQNVIPFPVTEIADIYLTPRIKQIPSKIITKNQNMIKSLKNWINNPEFFEKMKLGFSLSKTENDATKFHEICDDKGPTLVLIQSKNGNIFGGFTSVGWKSSVGNNYIEDENAFIFTLTNQSNLPQKFDLKPFEKNYAIRYYSNLGPLFGRGYDFGIKTNLKRGYSNFGYSYNLPEGIDLGSDQAKSFLGGSYSFVVRKLEIFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ18</accession>
    <name>A0A9Q0LJ18_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_08693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000074">
        <property type="protein sequence ID" value="KAJ5073576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ18"/>
    <dbReference type="OrthoDB" id="188207at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040489902" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="427"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5073576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="825" mass="93425" checksum="C1AD3C4D353CFBF6" modified="2023-09-13" version="1">MKLNLFFSFSFFLIINIFLIQSNQNQNQQKNSISKIIQELETTRLLTETTRYYSTPDEAWIWNLLDQFSNPGYFGHSVSIYEDVIVIGANVADQVFIYRYNGTIWNQEQILNGSSVSDFGYSVSIYGNFTVIGAYVANQAYIYRYNGTIWNEEQILNESSVLFFGNSVSIYEDVIVIGAPGANQAYIYRYNGSIWNQEKILNESSVPTFGGSVSIYEDVIVVGAPGANQAYIYRYNGTIWNEEKILNEFSVPDFGYSVSIYENVIVIGANDAKKAYIYRFNGTIWNQEQNLNESSVSDFGYSVSIYGNFTVIGAYDANQAFVYEAHFIPQVNIVNCSSLFSSFDCYWDKIECGLTLIYQINYGYDWIDIDSPILEDGNAYYQQFNSSNYDNITGNEYYSIQIKACDNETMKCGESSSFINLTTKIDSVKDFQLSNPSNYSINVTWDYPNVQINEGIAHLDHYNLSYFNQSQPDLISLISVDNSSLDYLWNNFECENDYNISICGCRTQECEGDDKGELVESSISLIFGEVTNLTCSIQYSLDINCNWNQPINCSIPFYYNLTYQSIYQNDSGNYQPTSLNQQFTQLQQFMKQFLKLKKLNLNFTKLTNANNYSISLNNETNWQNFTSLNLSGNEGIGIISGISGNIEYNISIRGCSDLNCETPYLGEPSSIISTRAKLGNITSLTCNSLINGFECNWDSLILSSGLKAYSFTYNSISICLSNLTTNYSVSGLKGGEYYEISIYSSADLNCSFNEYSGINSTTSITISSTNESNNNSKTTAITLGIIIPLLVISIIIIGIILYKKKKKKNQNQKQEEKQRRKRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJ91</accession>
    <name>A0A9Q0LJ91_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hsp20-like chaperones superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJ91"/>
    <dbReference type="OMA" id="WELEITQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="346" mass="41121" checksum="A7FE0ECAED2D8187" modified="2023-09-13" version="1">MKIEILNLLNYLKQEDKENNEDKENNNKENNENKENNENNNENNENNNENNNENKENKENNKENNENNNENNNENNNENNNEENNEENKENNENNNENNEENNENNNEDKENNNEENNNNENNEENNDNNDMILNQENQSKANKFFNKSEKLFLIFTIIFFLIAIIILQFNLWRSTKSNLTNLKELHYKSDIIESELNLMYNYRQNKLQKNNKEDKNLIRNKKYFSSISNSWKQNLTSIINILDDIQKNLSDWELEITQTERRISNNIAKVSPFEKSLIEFINEKINSNSNSNSNSNSNLKNDLKIQSSKKGRSIWKILFYLFLISGFCLGIYFGYPFILGFFQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LJN9</accession>
    <name>A0A9Q0LJN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein 78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08299</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LJN9"/>
    <dbReference type="OMA" id="VSKMMQG"/>
    <dbReference type="OrthoDB" id="9156702at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="122"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="523"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="692"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="335"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="799" mass="90879" checksum="D054E9D02C001D3D" modified="2023-09-13" version="1">MLSQIIVKKHSIQQLKLILPKFSNQFTNYFFQQSITNSKSDLKTNLKITKYVQENLFLTKPKNLNVRYFSSMQTPPKEQNEEEALKKYTKDLTELAKKGKLDPVVGRDEEIRRTTQILSRRTKNNPILIGEPGVGKTAIVEGLAQRIVAGEVPSSLLNKKVLLLDLGLLVAGAKYRGEFEERLKTLLKAIEKHQDLIIFIDEIHNLVGAGKAEGSMDASNLVKPQLSRGELHCIGATTLDEFRIHIEKDAALARRFQPLYVKEPTVEETVSILRGLKEKYEVHHGVRILDSAIIAAATKAKKHITQRHLPDSAIDLIDESAARLSLQQQSKPENLENLERLITRLKIEFESLKNEHDPISLDRRKQIQQELEQNKKEFDKLNQDFLKEKEELSKINSIKKQLEQLRIELEIAIRKGDHSNAARIKHGSIPQLEKQIPKESIQNEDSYHSNKLLRDFVTDQDICHVVSRITGIPLENLVAGEKERLLKMEHMLQKRVKGQDHAIKIVSQAVRLNRAGLHPHKGPIGCFMFVGPSGVGKTELAKALAEFLFDDENAMIRIDMSEFMERFSVSRLIGAPPGYVGYEEGGKLTEAVRRRPFSVVLLDEFEKAHPEVSNLLLQVLGEGHLTDSHGRKVDFKSTIIVLTSNIGSNIIGSLDENKSISSVKDDIISAMKRHFAPEFMNRLDDIIFFERLSLETMKKILDLEISSINKIFEERNIQIALDENSQNWLIKKGFDPVYGARALKRVVRSELLNKLATFIIDGKISPNTNVQISKNPSKEELSIDLIKKEKEKEKEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK09</accession>
    <name>A0A9Q0LK09_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fmrfamide receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK09"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="200" mass="23957" checksum="8EE21628E273FAB8" modified="2023-09-13" version="1">MFRQIQLFLNNLNFDPNTQSELFINFQLYIQKINQRIQTINQPDQNSKINDKKLIQLYEIEETLQKIEISFTNTDPFVALPIVVYFLENQPNFEETYQNHQNQYQNQNPNQNQNQNQNQNQNPKKNQKQNLNKNQNQKSKKKSKSKSKIKIKIKIKIKIKIKNQNKNQNKNQIKNQNQNPKNQNQNKNKNQKSKSKSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LL75</accession>
    <name>A0A9Q0LL75_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras guanine nucleotide exchange factor i-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_08026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000069">
        <property type="protein sequence ID" value="KAJ5074671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LL75"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF366">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="6">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="506"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="663"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5074671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="902" mass="106841" checksum="BB47BEDFCB0F0E4E" modified="2023-09-13" version="1">MDSLQIGHKIIANNKRAIIRYIGETQLGEGVWLGIEFSENVGKTDGTINGIRYFTCPPKHGLFVKQNHFTISRQKKLKKSQNPEQLKSRISKSKKELVRSPFFFKIRNKEIREKLRNHVFKFEQINYERICYQNYAENLQKTINNNKFDENIFDNNKKKGFEEKINQSKEELSGIMKENQKLREEISTLSKEIEQRNVTSFKSKIRRLTNKLKEMKKLNEEEKKKQEDLEKQKKKIQEEIQDINEQIHKETTELNQKLKMRIEEIYKIEQSRNQLLSKYSEIDEETSEEELKKLEDKIERYEEELQKSRKVALQFEMNKTKHEIYMEKIISPEDDISRTGWTSTVMKRHPEIIDLIERLKPLYRAISFARNYSGVKSEVRSQITRDITIQLIMQHFDHEGRQEIQQFIEENTKTPYTEHQIEDSRLFTLLKDCLRNTETIWELSMEPVENEEQLKERIIMIEEHASSMGLEFLMKNDISIWDEPSDNSSNILFENPQNLKEHQTSFLDKLVAANINKLIEKLTEETDTKFLQAFLMTYQSFMRPEHFLFKLKQRYSVPVRKMDQGEQEYEEKKKYVQLKVIAVIQTWLDKYFEDFDAKLLLNVENMISKIISQDHPAIVQKVNTMISKKKENKEKELLMTGKLEEPKLPRNIFKGNLSLSDIDEEEFARQLTLVIFQTFSKIQPSELVTKAWSKENQKHKAPNVTAMIARFNSVVGYVSSEIVMTKTIRHRVKKIVRFIRIGEYLLKMHNFDGLMAIIAALSTSSVSRLKFTKEEVPKNYIKSLDEMRQLLSSENGYKKYRDTLKEISTSCIPYLGVYLTDITFISDGSPNEIDGLINFAKRKLLYLTIKDMQNFQMKPFNFFFIHQIAVLFDQETSAKTEKELYKISLEREPRSATRQQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLA9</accession>
    <name>A0A9Q0LLA9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_08917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000076">
        <property type="protein sequence ID" value="KAJ5073235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLA9"/>
    <dbReference type="OMA" id="AMRMDYQ"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5073235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="770" mass="93103" checksum="6FD11DE9D48AC417" modified="2023-09-13" version="1">MKKGKKLNSKTSKITPNFLKKSGKTKKQKESKKEIKEKDQEKDQKIKTVDQQEIQNERKKETKNETKNETKNETKNENPFYQSKSENLDRTKNLEKRKLFRKSKSENQLFSIPQPTLQDLLIVTEHLQTKRQRKKENKNQNQNQNQYQYPNQYPNQYQYQYQNENQYPNQYQYQNQNENQYPNQNQNQYQNQNQNQNQYQYQYQNQNQNQNQNQYQNQNQYPNQYPNQYPNQYPNQNQNINKNQNQNQNQNQNQNQNQNQNQNQNQYPNQNQYQNQNQNQNQYQYQYPNQYSQNPFFINPQFPSHYVPSLSAYYFFNSQYNNQSNLMTNYNSNPYSQPYSHSYPDSYLPSFSQNNFIRFFTNSDSNSHFSRFTKSYSNFQNIDYFEGDFYRNNPQIQNQNQNINQNQNQNQNQNQNQNQNQNQNQNINQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNKKNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNQNENQNQNQNQNQNQNQNQNQNENQNQNETKMKIKIKIKIKIKIKIKIKIKIKIKIKIKIKNQNQNQNQNEKNENQNENQNQNENENQNINQNQNENQNENQNQNENQNENQNENQNLNQNQNQNENQNQNQNQNQNQNENQNQNQNQNINQNINQNQYQKRKIGLKIQKGDCVQMYSELGESLFAVILEIISFSNLDQTFCKVQWLIPKISNSSGIIKDSNLKIENLELDDFYLGNIEPSLQSTRTIAAKLKFRMENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM15</accession>
    <name>A0A9Q0LM15_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Denn domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_07277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM15"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="22"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="554"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="845"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="586"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5075307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="915" mass="107120" checksum="0CA5009585BCC152" modified="2023-09-13" version="1">MSLSSIEEKFFEFVVISGMGTELKIEETTTTNKDPIFIPEILFVEPNTTTSKEILMHLSYFLSPEGGIKLHEKPQDDISHSFILTNNDGGRLYGFAYSKYFKLEFKKQHKIQQILNEKNMDYPLENIYISKTIGIISKFPFHRSFSEILSNFVSGTKNLNYQTAKDLSDLLLKIESPKISRSVQQSITIDSQTKITIPKLNHSTELPIFDIECSYLFSSLDPDNIVLLLNLILNELHILFVSDNVSKLTPCMEAIVSLLYPLEWLNPYIPFLPESLKEVLDSPTPFLIGTKTSTLDQMKLGEDINIVYLDINLITVSVNYTPLPQRICNRLIKTITKYGNIFVKDRKPRVRGNTTQTKSNNPKIIEYESTSFSSSDSEESVDEKEQVLPVYFQRFEHRKTIQNTNRKSHERSRTMTIAMERTMNHELLEKIDISKMKKNQEEKIIDPSQKNQNKINSEKVREGFLSAFVSLFKDYPYFLSYSSESNTFEINEDAFILGSNEDCKLFLQMFTRTQIFFVFIENRIEKMGSNIDYFHISLSQALKKRSLKYSQLIRKEKKGFLFKQGKVRKNWKRRFFCIERSKLNYYVQNQEENQNQNQEENQEENQNKNQIKRKLKGSIPLIPGITRIKIPKINLKPFLFQIIIPEREYNISAPNQKELKSWVLILKTACFSENEIKKLQNFSPITSLEKFLPQAILKKETQTKLKKLSSTILLKKSTIINLGSFRRNKRQSLSGFQNLAEEIDTESETESDENQNENLNLNENQNQNENQNLNLNQNQNQNLNENQNQNQNQNQNQNQNQNQNQNENQNQNQNQNQNENLNQNQNLNQNENLNQKENQNQNENLNKNQNLNQNENQNENQNLNENQNQNQNQNQNQNQNQNQNQNQNQNINQNIKIKIKIKIKIKIKIKIKMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMI6</accession>
    <name>A0A9Q0LMI6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tyrosyl-DNA phosphodiesterase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_08414</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMI6"/>
    <dbReference type="OMA" id="LYENAHI"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="16"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5073850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="608" mass="72324" checksum="5B478C75FE3DD562" modified="2023-09-13" version="1">MNSNNSEEIMLQNAIYNSLNSNQNENKNQNQNQNQNQNQIQNQNQNEIQIENQNQNQNQNQNQNQNQNENQNQNQNQNQIQIENQNQNQNKNQNQNQNKNQNQNQNQNQNQIKNQNKNKIQNKNQNQNQNQNQNQNQNQNEIEIETDGKIFFQNKIQNKIQNQNQNQKKYFISLKEIIGKNVKKVLLTSFVYDIDFIFSSFPKNIPIYLIADWNQKIQKPGEKEIENEKYKNIRLFYPPKMKFGYFHSKILLLVYETKLRVVVSSANLTFEDWNLIGQVIWFQDFPLFQKEKEDSIKNTITNFETQLNLFLITCKLYWLIPIFVSPFDFSLANAQLIFSIPGNHRNFNTWKVGLFQLNDIVQKFLSIQFIQNEKNSNENPNENSNENSNEMKIENQNIKIPFEKFPFDSLMFQASSIGKYDNQDRIHDFITHACGKQIYENQNQKKEDEKKISNSNSNSNINLLKIVYPSQSIMKKLIQNFEHLNGIGQLFFQQESSAYSILKPFMYECVSSIFSRQNIILHSKILIAEHPYFRYYCIGSHNFSSSAWGKIYHDRNSKLVIYNYETSVILFEMKNKKEEKEELTNFLPFTYPPSKYEDEDLPWRNPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMK6</accession>
    <name>A0A9Q0LMK6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hsp20-like chaperones superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMK6"/>
    <dbReference type="OMA" id="TDQHESA"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5076296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="231" mass="28338" checksum="5C9625BCFE514D55" modified="2023-09-13" version="1">MIEKQGFQIINILLKKIHPKYFSTQIYYIIRTFKENIENEQFQKQLKKYLIFDYKIWKNYNFKIQNKLIETIQICIQNQIIKIQIQIQKEKENQNQNQNENENQNQNQNENPNENQNQNQIQIQIQNQIENQNEKEIQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENQNQNQNQNEIENENENENENENQNQNQNQNEIENENENENENENQKEKEKSKIKNCKLIYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMN5</accession>
    <name>A0A9Q0LMN5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="4">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">M0811_08198</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SH3RF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="4"/>
    <dbReference type="EMBL" id="JAPDFW010000071">
        <property type="protein sequence ID" value="KAJ5073925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMN5"/>
    <dbReference type="OrthoDB" id="1658195at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="82"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="370"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="462"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAJ5073925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="518" mass="59911" checksum="84B031504A126950" modified="2023-09-13" version="1">MESIVCPICFETFSNEKKPIIICEQGHTICQICLKEMDSCPFCRSSFENSKLIINRPLLSIIEEMQKISIKTIPVIPLEELEIESQPFQISDLSYIYKAKWRNSFFALKKLRTFDIEKKDKFKNELNLIFGLNHPNLVQVHGIFEFENSIGILMDLSEEGNLKDKIANLSFEDSVNFSIGIVQGLAFLHRNAIIHRFLKPENILILKNQPRITDFGLSKLYQQESDKKSLTFSNVYIAPEILQHKYSFDTSCDIYSLSFILYQIFSKEKLDAEKFISEQKKPIISNNFPRDLAQLIQKGWSNDPKNRCSLNDFLKCLEEMRSLLNQKNIEDEKKSKSQTGEFFGSIIEFERDEKKPESLRRKEKKHSKKSKKIFGFAKLDFQSPNQTHLTFSIGEKIEILKILQDGWGEGLLDGKVGLIPLNFLEIIEEEIDQKNWKPRSGPKPVQVKIPPKIFPAKVLYRPPKLKMRAILDFKGENGELSFEVGDIVEVIEKDDSGWWKGMLNGVTGVFPNSFFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMU3</accession>
    <name>A0A9Q0LMU3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMU3"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="222"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="895"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1138" mass="132612" checksum="34C6E049D8944FBA" modified="2023-09-13" version="1">MPLHYAVKKQNTDLCFLLLDRNANPYLKNFKGINPLKYASLKKQYSFLFVILDVALINACFYRNNTNIPQLINDGANVDGQNLLTFIQQNEIKIKKTNTSLTEKELKDISKYGFRYLINMYTNPLLATVSGQNFAAFDILISKFADIKQQDYFSGATVLHMAILRNDVKFTKILIEYNATISQMDSEGKTALQLAEEKGFTKCKNMIELFEEVNVQHFPRYKFPKISFGTFDKLLDRILTEPLLDYQFCIHFLYFFRNFMKRKLFLKKLITIFENPDEYISKFIYFEPELSNKGKFVRARITILIVTWIYELFSDFHENNLINKSNFPKFNFLVLNQYKFFNVEKFEEQMKKVEVFYIQNYASKKQDKMPLGDLNKIFYEEIKKIEEMESKKKRKGKSKNAEQTIKSSLSEQKDITSYSSFGDSKDENQEDENKDEKEEDNNKDNNEENKEDDNKDDNKDENKEDQNINKSINENINEKSNIPRSQPRGTRRGSPRGSPRGQPRGSPRGQRRGPPRGQRRGFPRGFPRGDPKEPPKQIIRGIPRGGLKNKINLFQNVSNESNKKESEKSGQTSGRRAPQKISRTISSLEQFFQVKPQETPPKEKSPTPLSKPSIRKTSSSKELLPPKLPPKTAPKLPIRSQTEPIELPPPPPPITEELPPLTSFPQLTSLPPIPPIDSEMIPTEIPPIPKPVQIERSKTENSLIQPPKSTSSFESKIIPKKTQSQTLSKENLNTLFQKKQKESETKEEFEPNQIFGILLDFLSRNTTAFPAEILPIKYAVSEQLEQFSQKIFTETRTQLVNKESPNWYDSWRLDDDVIKVIEKDIANNNEKLHFSFSKKEGALCVQHKDWHDIWVYDIFAKPEIYNIFQQEIPSSILRKKKTSKKHVDDVVLDNDSLELARQISLIEFAFFSKITPLEFRNWGIFVKEGFQKGKPKIKNVKNMAEYDQYLKNLINWVVYHIVKYPKMSKRSKTLFKLVDVAIHLRKMNNYASLVTVLEAFNQDPIARLRKTWNKLGKQQKKALQELKDELKELQLKSQYKNHYKALHPPCIPSLEHFFTDINSIESSYIDIDEKNRIQVEKFVSQFRLIEIISNFQRFPFNFNHVPEIQSAILNVPITSAQRLKEFSLLCEKEPKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN81</accession>
    <name>A0A9Q0LN81_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LN81"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="310" mass="36588" checksum="C2F9EC31112E7949" modified="2023-09-13" version="1">MNNQENPEEKNQKENPNQNEQEKKKIENKNIKKIQENDNILTNKEENTENQTKTTSTTTRRLIRLTPQRKYLSDRFHISQQNSPDSKRTQSQDFIQNLISESEMRSKNNEPKLNIKTSILNYKNLISDVSVIPLSDLLKIIYFSIEETEKNGENTGYQFIKNPNPNPNPNQNPNPNQNPNPNQNQNQNHKSKLKMDQNLISSLNYISAICFYRLNEFEKANAKINDYLSMNKKCRNGFLLQCLISMKRKDYKKAKNALRKAQKSHQTNEFPNYFAIVSAHLYFYTQESSKKQRVNWIKYSWKMLKKCLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LN90</accession>
    <name>A0A9Q0LN90_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Muscle-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1519" mass="179839" checksum="57068D4125522876" modified="2023-09-13" version="1">MNKQLQEKITTWISTQIGETVDFEIQKRNQLTIQLCHLFNKLQPNSIQIEVNNPQKNWDTFTKSCLKYGVQKEYILTYNDFIDKRFTSALLILVYQLGVIARTKTSSIQSKRHSKTFSSQDFDNSMIPDKNDIDLNKTDQNPFQTPKKKTIQEIINDEKLESYSKIKSPILIKKQNLQEESFIYSQKTLNINEWKNNDDELDNILFLKKNINGNETETENSHYSFSHHLINYYSTQKISTEIQKNIIQKFFILGKARFNFKYIENKTSAPKLGVIELTTEKFTINILGTGVIAISPYFLSPEVYLSVEKDDEHSLSICFNEEKKIKMKFDTKNEAYIFSKTFLMFQWYKGIFIEEFPINGNIIGKEFEIECVALRTLMNKTASFQIEIENQDRNECGYCVLKLELNQLNLITNSGIISLLYQANILSFQRLTNPKKMIVLKILYKEFEYFIKLICKTDLKQELIFRTLQIFHRNSKRNQIPKNEKSINLDFIEPNFGNYYPKNEETNIQEEYFKNDFPFENLVFASFNNDGTTETFQQQNLPDLINTNILKSNFISFSESIPKVSKIEEYLQNGKTDNFPILLLDSGIYSNGTLTFTQERIRIFLTSGKLLMENEFSSIQRIILNPFKPKFFSLQIDQFSNFIIKVKSEELRNIIIYSFLLFQKNYLDLKTSKIFQTNDQNINLFKMEMFQDPNIKQFFLQNKTRTILYKNQNIRIVNEQHKPNKYKAFLYNGFYDLSGDITISLYRNHFSLNFQNNVIKKRYSIYTKLLEFYKGIHVVFCRIMIDEENFINISFPNCEMFQIFTRDFYSKRKDYFKSLQDNFQPRKLIFDCKINIKENQKINGNIILAFDSFTIKSSEYKQSIFEKIRGSVTNESEYGAFNELLTLEYSPMITLKKPKIDNSIHINLGIENAFISLVFPSIDEETKFIHKFESYTQYYNSLIQNLESLYPINTIKSEPKMVYAKIIINDSYIGKCQIMKESNDSNLLAFIQKDLTKFVFNVENYQLYFNNKYPNECKLETLKNEISLTFSDLRKLQNFKNLLPKITENNQEENIKQFNGIFYLIQSQNFLEGYIKIFQENQRIIIASGEEKIQSESIQKTNIFSHLTKPKMIRIQLSNGNEFLFSFYHTLDKNNFIELFQQIKDENENENENENENENENENQNENQNQPIKNLEPIRIEEEKDLSVEETKPKKQREFREFLNTLENDINNITLETMEYQIIIFDNSKIRNEGKVVLEEDCFIIESQKLNKRLSYLKSSLFIHPKNNVLCKFKIEEDEDELKQKQGKEIDLIENEPQTTELYFQFLTSNLAKIFIDKFKTQKEKEIFHSKNQEELKKQQEEQECKKDTNIFYIQLVDETLKPKGNGLLKFTRNCADLHLKTNVGKINLNQVNHLNPFIEDEDENLKKNKIENENKIFSVKFIKGNQENISGKQGTITLENEKCIIKIGTDKDLEFKLNSDSQFLYSEQKSKVGKIIFDSLHSFQFEFIDTKKRIEFSKFFRESLPKKMRLRSAEKNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNB9</accession>
    <name>A0A9Q0LNB9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylate kinase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_07114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNB9"/>
    <dbReference type="OMA" id="INCKVNA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5075544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="221" mass="25356" checksum="3B00019B4B8377BF" modified="2023-09-13" version="1">MNSKLFIVLLGAPGSGKGTQIPTILQKYKLDLFSTGDNLKKEMKNETLLGKKIKYYLANGKLVPDQIIIEMLEDLVFKKSKKSNGFLIDGSPRTENQAILFEQMLNKINCKVNAAIDFLVPDNILYERIKGRLIHVSSGRIYHKKFNPPKIEMRDDITNEILIKRKDDNPKILKKRLKEFHKFIPSVRKFYSKLNVLITLNGNQSAKQLSNEILISLNKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LNI9</accession>
    <name>A0A9Q0LNI9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LNI9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="338"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="443" mass="52409" checksum="D31364BA714945A2" modified="2023-09-13" version="1">MIVYFLVEINTQNFSKKNQKEIKKQIQFKFENENENENENENQIKQISSGYFGTIFLFKNGKAIEYLKENDSKQNPEKIQIEENIQKVTVGYHNEAILTIEGNNNSRYCFWYSIYLLTSNQNAYGIGSNEYGQLGNSSNHVFLLNSNQELFGCGWNNYGQLGLGESRKEIKIQKLTKIQNIPKGNGNTNNQLIPIQIELPKLRFNENISNYHISCGLYKSFLYYSSPSFSNLEEDLIKLFERKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPD1</accession>
    <name>A0A9Q0LPD1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BEACH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GTEDISC"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866:SF1">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="297"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1264"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1306"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1437"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1208"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5077241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1583" mass="185754" checksum="97B46FED6FC82FCA" modified="2023-09-13" version="1">MGQIFTKQEIEKLLKNDFNELIRFQHTFFSDQTKGNIAICYVTSENFQKITKKELPNYFKKEKGESDINLYKVIVEIISKDKSKIIQELKNLKSKTKTKSKTKSKFKSKLKFKSKSTSNLKSIYKKQKMFNLSNYLSYITDFSSKSLRLKNIENENENQNYEIDKIEEKEKEDKFELINQLITNDNFEITYDLVSKLHNQFNENQGILTSNFFAETKRAIYIFYPSFKYTLQDILQYSPRLLGTLTQKLFVIYQIIRSTTDLHKKGLYHGDIKPSKLLLTSQKDIWLKLTGFTPATIDEYYIHQQKSIFEKWYQREITNFEYILYLNSLAGKCTGDPNNHPIFPWIIDFTRDPKPFLDSNENENGNKSFISSFRDLSVSKFRLIKKDEMLDQIFKTYKYHISEGLSEVSYFVYLARITPLPILRKFVRSNYNPKEYPISIERLYSWTSDEAIPEFFNNPEIFKSIHPDMPDLAIPSWANSYEDFCNIHMKLLESEYVSQNLHDWIDIVFGYKLSGKAGLEAKNITQTNFSTPHSHGFIQLFSNPHPSRSIFINKIENENENQNNENNENQITYRIEDDETEFINKNLSDYKIYNSLSQNYWMKNYKITYFSNPLAFKDLSRNYIDLYKIEFHSLFIPSFSDCVVTYQDFYKTQNLFKDPNQKQIENKFKSVQELISRDLFSIGCIFVEIFTNEPFYTYDRAEYSSQIKKIPDSILSKLPEEIRVTISNMINPNNLRRLKSKQILNLNLFPTYFSELYDILSKFHSLETIEEQFHFIMNNLEQILTLPKEGFKILLPFLTEFFNITQTKLSTLPIFVKLPDKLGRKKSLKLLGAPIKSLLQYKDEKELANQLLQINFIESLSLKFGVHYFLQELLPFIFDILRSNDLEISRFAKRSLIAFIDKFDDSIFLKFFVEPLIKLLDKSNGKIITDALISIISKRNHRKAISQVVLQLLLKFLEEKKSILCLSKGENLVINFLNVSRSLIIDVNQKFLISKLNAGAFDPLFSIFDKPILFQDKLVIKLFITELLAISMKIQQKETVHFIFPVIDKFLKNFTDIWTIPIEKLNQESNQHKTLENIDPFQNLQEFSIEEYYEAYRELYTHENAFLIRESIDLFINNDVVDKLDTILLLDKVLQTNDFFKDFIADNPIQIDLQKRFGNKKIEKLLTNQSNESNQEIEIEKEIEKETKQPKKKGGIYSLFQKKHKNEISNQQQTTKPIKQQNTEEPKTSFYDPDLHWIPKLIIDGEYYQNTNEWDLKGKIAHSHKGHNSSIRSLDVDSNEFRFATASRDGTVKIWDIDKEEQICSYFGHKQSVSQVSFLNENNWIGSCDTTIHIWDVQTQKRLMHYGLHNINHNLHLLAFVHLPQIGALVAETNDSKVKLIDLRTNKFGCEWNVQSQCSGFNRSICVDESSKMIAVGLHNGDINIIDSRMGTVYDSWKAHDSSITQVFFYENDKKRLLSLSSDKKILLWNLYSSLKEDDNGLFPNQNQNQTQNQTQNQTELFKGYNFYQKVTCFETYQDVLLCLIGTKIGISSLNTKKLKNIEEPTISVKKMQNVKALSSFSILEMHRLLLLGDEEGNIHFCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPF0</accession>
    <name>A0A9Q0LPF0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_07065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPF0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="111" mass="13301" checksum="36E7D5B6963770A2" modified="2023-09-13" version="1">MMNKKDEKNESTNKEVESILTNQLPEKQNQEDDLKRKHNKTPEITPVKNLQPPQKKYFNKEDEYISDEQESSDEVDKKTPNKNESKKSKQRSKKKKRDKKRKEIKKKKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPG8</accession>
    <name>A0A9Q0LPG8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA replication regulator dpb11-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPG8"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="87"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="242"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="495"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="619"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="916"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1109" mass="129274" checksum="6619DE6F7D077D5E" modified="2023-09-13" version="1">MTLFQSNFFYISENISTNPKKLFNILIQNGGKVLEDFNENAFIISEIDPNKFNQYPSNLITPNFIYESISLSKKIMKLNHPFHSYCLNGENIYFNNLSTNKHKKILFQILCMNGQYSTEITPQVTHIIIDISEENRQIINDPRVIDIEWIEQCWNNHRNIKSIIFPQFSKCCISTTGFSEEETKNIENLINKFSGEIHSAFIKKTTHLITKIFKGSKYESAIRQKKTIVTIDWLKKMILLTERNQFFRNCIFYFDPNSIKSSIISILKENVLKFGGIYLDNFNNQVTHLIIQRTDGEYYYQPEWSENSKIIDIEWINECLRKKKLVNISNFSIFPTNLTEESSFRSSLTANQNVLSNAISSDSKISQNSRTNSIAIDDIYKRKSKSFNKKKRDSNIDIEFGNQNQNQDQDQQIKRQKQRKQQKNTEKEIIPKSIPINNLKNPEISISLNRNIENISIENEKEISKLNLSANYQQNTLEYIEKQNEISGLNYEPYEANNLFQGISFVFVQVTKKDEEDCAKLIKEHGGKIEDKITNETKYILVSHGASILISENFRETYEEILVSKNWLERCCFKTLIYNPREYCIFKPLKKAIPFEFMKQFRISLSGFKKQMKIKNKYIIKQLGAKFTGTLSRKNTHLICREAKGNKYKKAILWGIKIVNENWLCYIAESGEYLNENDFLFFNQEEKNTNLNTNTNTNTNSNQKTEIDLFELDSTPQKNSKFQTLEYSKPRNSIKSINSDFSSPLYRKKITDSNYSESNSDISYSLDTDAYNYEVDEFLDDDTQEQFIFYILSKTKNKLRLKEIVSSTLNSACCERLISDVTHVIYSKEDEESEEYKEALSLKKILVKDEDVYGFFDDPIKLTNFLKSNRKNSNEKTSSYKKSPILVNSTNFGGLKQLQTPEKFKHELSNENTPLSIKKITNSKNTNLKNTNSKNPNSKNPNSKNPNSFQTIISPCKIVSPTTTSPKNNLEIIDVLFSKQKSPSHKVKEKYLENLENSKQNQFRRSDLNIFSQFYDNSQVEKNDLKKTESKEKNENENENENENENENDNENDDDEPNPIVIWENSNQENGKNIQTFSSNDSDVDLFKINGSGSKTFIEAYHKMKNKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQS4</accession>
    <name>A0A9Q0LQS4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mucolipin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_06494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000062">
        <property type="protein sequence ID" value="KAJ5076215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQS4"/>
    <dbReference type="OMA" id="PMSVPHN"/>
    <dbReference type="OrthoDB" id="311187at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072345">
        <property type="term" value="F:NAADP-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039031">
        <property type="entry name" value="Mucolipin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127">
        <property type="entry name" value="MUCOLIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12127:SF7">
        <property type="entry name" value="SD02261P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Polycystin cation channel PKD1/PKD2" evidence="7">
        <location>
            <begin position="346"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5076215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="636" mass="74334" checksum="6393DF19D52DD018" modified="2023-09-13" version="1">MSNVADEPKIGSFCCIKYNKIPTEKYLTMSPWKKWKKYKRIPIKFILHILIVVSIIIQAVIMTKYELPFMRESQNLFANVFLPNADFYVDSIDGRIQKDLNLVSDFNQTIYNITQAFYNFTNLTISFFDYDYDSGQINPPTLKIQKYSMYRFDSVDPNNKLIDFSTEYVTYPLTLENPIGPFTNMTTQEIQLILQTFRTANINFKFHCLYTTEIVQAVTWNIDILFDFTIRGGVMRASIDSTMKFDNFQESVSFRDIFPSIGFLSGVFNVIFSVWALILSIRSLRHQYRIYKETTSIISIKEIATIDNFFRDSVDFKLAFFNFWVVLSLLTSLINIIAEISYLIGQFYAPRERTSVLFIMMGFSAFFSWISLTGYFQWHKRFYLFISTLRRSIPGMIRFVIGTLPLFLGYAYLGTLLFGSYSKFFATIDQACVTLFSVLNGDVVRDNFNAVYRHNHGLAFLSRAYMYIFCCTFIYGWVKFFITVVESSFSSIQESRKGPNIERRKRLRPYIHLHRIYSSSRTTSVADEAVHDVSEKTTSTNSVSSVSFDKIGDIWEKEKQNKEKETENENENENENENQNQNENQNKNQNQNKIENQNKIENQNKIETETEIETSSTHPDFNSQSNDEISQQEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LR52</accession>
    <name>A0A9Q0LR52_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rrp15-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LR52"/>
    <dbReference type="OMA" id="FDEDYMY"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="239" mass="28635" checksum="128C7C558FE72D97" modified="2023-09-13" version="1">MNKKNKEIEEEKEIETENEFDEIKQIIKEAKQKRRKKKQKKKNFNKKKKQQNSTEKTNQFKTQILQILNEDIKKVDQPILSQNKTSSKKINQIEKQKKEKREEKLFKASQIENKNKQYKLPTNDEYDRKLNRIATIGVVRLFNAIQKQQSIPTENSDLDSKQLSKGKFLEMLKSQDVKVSKNQDQKNIQENSPQNNQKWEVFRDDFLLDAKMKDWDQKNENENENENENHDSISEESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRC1</accession>
    <name>A0A9Q0LRC1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear mitotic apparatus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRC1"/>
    <dbReference type="OMA" id="ERPEINK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="729"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="834" mass="99668" checksum="0465B44F9D235064" modified="2023-09-13" version="1">MANVDELSTGKVSQIASIFEQKSKKPIQNVFKFSYERKPNKTEDKIRTTIIGLKKYKDKLEQELQNVKKENERLNEKVQSLSFLLKEEQLNKSESKSDEFKKKKKELKKLIQEKDQNLKEFQKEIQNLKEIQNLKEIQNLKENKEIEEKNNELINEKKKNQQKQEKLTQIIQQNQNKIDEYSTKINKQKEEIESLNQKIKNLIESQQNNEKEQQKNVEKIKNDSKLISKQKEEIESLNNKITNLLALQENLENEKQDALTENYIKIISELKQEIQLMKESSLQDNFNEELKNQIEENSKLSQLNSQLELKSHQFEQKYQKKKSKYKEIKNQNFPKKIEETNQKFNQISSENENNKKLNQSFQNEIAHLEKEVERLQKENEELKENEKLKENQKNLEDENERLQKENEELKENEQFKENQKNLEKEVERLQKENEELKENEKLKENQKNLEDENEQLKENQKNLEKEIQSLNLKMGEYSQLTEKKESEISKEEFNKIIQEKEQLSYRCADLYDENFQIKEEKKELKKKNKRLMRQIKANLISTEKSKNNNINNDMNMNKKEKNQEDEENKEQQTKLKKDLSEQKDAIIQILTENINQKTTQLEEALIQMEALEQIIDSLDTELERTKIEKQIMKIELEKSNSFRKALEVELGEEFDSQQNEDEWVNVIQRTPSKSIETTPKTPRKQKENEVKEIAKQPSKENIIRNENIKPRSDSYDELVSKFNRDNPLSIDLEGEVKFFEVSNQKKKLFSRKMKGKRKNLILSGNFLIVYSKNDKKPEKVLDIRQNQVYLGTEQVYKTKNCFIINYSDGKCVFSTNTSAERDDWIFKIRSHQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRF4</accession>
    <name>A0A9Q0LRF4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRF4"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="172" mass="20690" checksum="45B3B307E8D26A33" modified="2023-09-13" version="1">MENLQFHEQLRKQKTQSENEREMIVNEFFQILSTRNQQIQTLSETLRNLSVFTTKIKNERDKLVEFLNNHEFGSFDVEILEKERKEKQELIEKNENLESTLNQKENQLNQVKIQYESCLGILEENQNQNKQIIEEKEKIQEKNTQDNLLLLSILTNWNQKSICYPKKMESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRN1</accession>
    <name>A0A9Q0LRN1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related protein rab-11a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000056">
        <property type="protein sequence ID" value="KAJ5077777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRN1"/>
    <dbReference type="OMA" id="CDVHENH"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000274">
        <property type="entry name" value="ras-related protein RABA5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5077777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="209" mass="24319" checksum="39E054DA5A18C6D9" modified="2023-09-13" version="1">MQQKERNLDNELSLYSHVFKVVLIGNTHVGKTNLLTRYRYNTFTTESTSTIGVEFSSKVFKINNETIQLQIWDTAGQERFRSVTRAYYRGSYGAFIVYDIADEESFEKLEYWINDFKDQTDQNVVIMIIGNKSDLSDKRKISKEKGQKFAAEKNFLFMETSAKDGTNVHKAFETLITEIYNVFSKKKLTPPPINLYNYKEEKTTEGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRR7</accession>
    <name>A0A9Q0LRR7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basic-leucine zipper transcription factor f-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRR7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="159"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="259" mass="30665" checksum="0F513FF35E6B3DAA" modified="2023-09-13" version="1">MFVSSEFRNSRTSQTSQNLIDDSLDQIDYFPIEEQSGFFTTFVDPKPIDNNLEKQQENEQQQEEKQQQKPKETNQKKPRRKKQKGKHSKTHKKTKKRKTQDDEEDELSCKTKKPKKKSSKRKKAEANVIVTIKDGLGNEQSIDLAGKLTREQLRLLTSKQKKQRRMIKNRKSAQKCREKTRQRIEELSEEISQMQEVRVEIESQVENYKKENLLLHQEIEILKKELSRTREQTGLYQNPISQAINDPNIFVSDMRNFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS53</accession>
    <name>A0A9Q0LS53_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_06276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS53"/>
    <dbReference type="OMA" id="VANEQKQ"/>
    <dbReference type="OrthoDB" id="8116123at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042282">
        <property type="entry name" value="FKBP6/shu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46674">
        <property type="entry name" value="INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46674:SF1">
        <property type="entry name" value="INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040320101" description="peptidylprolyl isomerase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="186"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="620" mass="72605" checksum="9ED5F65B4C025E25" modified="2023-09-13" version="1">MSLVFPSLFIVSFGVFAKKSSIVKDNGIIKLILQEGNGEQHLIPNSSKVQIHYEARTKNGIIFDSTWNRNLPFHFKMGSPNLILGLSLSVSTMLPNEISEFEIHPNYGYGELGAPPRIPPNETLFYTIFLIDVQEQQLILPQEISSISLENQIHLALDLKQKASIFFNKKQFSEARKSYNKAIIILTKIRKEMRIQNQNQNQIQNQIQNQNQNQNLNQIENINQNQFQNQFQNENQNINQNQNENQNLNQNINQNQNQNQNINQNQNQNQIQIQNQIQIQNENENQNQNQNQNQNEIEIQNQNENQNQNQNQIQNINQNQIQNQNQNINQNINQNINQNINQNINQNINQNINQNINQNQNINQNQNINQNKNINQNINQNQNQIQNQNQNQIQNQNINQNINQNINQNQNINQNKNQNINQNKNQNQNQNINENQNQNQNINQNINLNQNQNQNINQNKNQNQNINQNQNQNQNENEIEIQNLIQIIQTNLALCCLKLKNYKKALNHCNESLKIGETTKALYIQGKIHFENKNFVSSKLYLTKALKNSPKNKKIITLLNECEKKLKSGNFSQDFSTPFIKEMGKALIKSIDDKINQENQNEILDFEKELKEEDQYLFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LS59</accession>
    <name>A0A9Q0LS59_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrosomal protein of 44 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LS59"/>
    <dbReference type="OMA" id="NKRINHY"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029157">
        <property type="entry name" value="CEP44_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15007">
        <property type="entry name" value="CEP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomal CEP44" evidence="3">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="454" mass="55195" checksum="9F65DE97FF043D92" modified="2023-09-13" version="1">MNFFHFLYQNLQKEVQNISFPNKIEQNEILEGNYQIFISIFQHLIYKTSSTLKKYFEKENLKFENKNNDFEFIKEIYKLAFKFNLKPKVSRKQFFTKDFIIEKMEFVIKMIIECRKIYKLKKSKQFQFQFQNKNQFQNQNQNLNQNLNQFQNQFQNQFQNQFQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNINQFQNQNQNQNQNQNQNQNQNQNKSQNKSQNLNLNQNQNQFQNINQFQNINQFQNQNQNQFQNKSQNLNQKLRPKHLHKKKELLKAHQVKFDQFQKQSNQNSLNQDFYYSSSDNSLSNSASLKKELKKMLFYQNSIQKIIENFEKQFKFLNLKLEARTCSIEVRLEQLERKINHLEKEIHEIKDLLLKYNTQYNTQIGLIKNKTNNIKKFLSNSKKNLISNSSKNVNDLDLINSFEKSQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSG2</accession>
    <name>A0A9Q0LSG2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000043">
        <property type="protein sequence ID" value="KAJ5079026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSG2"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="310"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="387"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="477"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="69133" checksum="B19E902A45C91D4A" modified="2023-09-13" version="1">MNEILFWGENEYPKILKHEPKIIKKPIQFKFENENENENEKQIKQISSSNSSTIFLFENGKAIEYLKYSKQNPSKIQIENIQKVTVCCEDEAILTIEGNVFAKGYDINPKKSPKEFINISSLIEDTNDRIIEDIASGFNSIYLLTSNHNAYGIGSNHFGQLGFDSKTFKKTRKPILMMKNVSKIFSGNTSQFVFLLNSNQELFGCGYNAYGRLGLGESIREPKIQKLTKVQNIPKGKIIDIQCGNFHSIILIENPKRKLYSCGYYECNGLGKNQEDTYEFTEIKSSLFENDNIIDFSVGYNHNLILTSNSKLIVFGNNKHGQLGTGNTKNKKIPIQIELPKLRFNENISNYHVSCGSFHNSFLYYSPSSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKKYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIEITQEIIDEIQIGIDYFQLNQTNPNLFDLLIKKFNNQNQKKKENCFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSX4</accession>
    <name>A0A9Q0LSX4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-actinin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSX4"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="258" mass="30448" checksum="DBBDF7D73EF2793C" modified="2023-09-13" version="1">MLNEQTFLNWANPFLSKRDIQITNVKEGFSEGVNLPILIEEVFNVKLRYKPSPKHRFMKIANISIAFEYLKQIGLKNLCDPADFVDEKVETILGTLFNIMKSKNRQYLSPKKLNRMSTYLFPNTEPLNKQKNETKLKRSQTLSVSSKVMRPKFDRFEELNLNYQKQKAKKQINFNKKDEKKNLKSKEIDLTSKNESIQNSKQIEKKDEKIEKKNIPKSESVSKRVNFQENNQNQNSKQIEKKDENIENQNQNQKIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU28</accession>
    <name>A0A9Q0LU28_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU28"/>
    <dbReference type="OMA" id="KLMNWIF"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="264" mass="32127" checksum="01C301DC2BFAA979" modified="2023-09-13" version="1">MENLYKQFDIIEDESYFDSISQQETKDKMKELEQSIHNLKEENEKLKENEVQLQNFRSINDSNEISILQEKLDEKDEEILELKKKIEDISIKSNEEFELKQKEFEQKQKEFELKQEEFELKQKEFEQKQKEFELNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENQNQNDLLKERKRMEKNITKLMNWIFLQLQKIFKNEEKYDGKTILKTSAEIIKHGTTQLVSNINPKQEENLENKKDKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV17</accession>
    <name>A0A9Q0LV17_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV17"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="287" mass="32973" checksum="8886AEC4FCBF23AD" modified="2023-09-13" version="1">MAIGKSKKTFKKKGRKKVVDTLSKKQWFHVRCPNLFKRGTIGRTCVNPTAGGKNSADSLKGRVYEVSLGDLNGEETKSYMMFKLKCEEVQGSNCLTNLFGMRLTRDKLCSLIRKWRTLVETHVNVKTTDGYTIRIFCIGFSQRNKKQIGKTTYIQTSVVKRLRKKIVEILINESRCSLPELMTKVISETIPEKIRKTSCRIYPLTNVAIHKIKVLKAPKVDLGKLMDLYRKKKEEVGETIPRETEETTQDSENKVEVLDEKTDTNQNNQETTQTNENDNDNQEKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV47</accession>
    <name>A0A9Q0LV47_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV47"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17268" checksum="E2061828B79E9E16" modified="2023-09-13" version="1">MTEQNKVNKELELVEESQILELVSPTEEQNEKTKINQNENENENENEDLESNQINDSENLREDEDQQNKLCSAKIISLKTDSKFTSLLILIGTVILFFGFYVFSKHSGWAIVCFSFGPLFLVYGSYLVFYRFYHFQQRYFDFEYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVB8</accession>
    <name>A0A9Q0LVB8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_05371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVB8"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="237"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="327"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5078113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="403" mass="46611" checksum="34DD1270371ADAFC" modified="2023-09-13" version="1">MQKQKMQIFVKNLKGTVIALDVDESETVDSLMEKVHESEGIPVKQIRLIYKRMQLQSEKKIKDYNIQCGTTIHFVLRLRGGGISPDLEFADMTKDAWKTRDFVTDAPDWRYACNGLNLEGKCTNKDCKAHNQWVIIQFGFGTFEISSHDILKKCVCPICKQLVESEKPAFVDCKWKFGGIKKENGKMKEESSDWKTVDNSYHVFDLEKGGTASWKSLILDAKKINEELPEDENDSIKTVYLGNLPFSVTEEEIKKEFSKFVEVEKVSLIKKNGRSAGYGFVDLKSSTDAKKIIENFPNFQLKGRKIKIELKDENKKKNNNQKQNSKTKIHITNLSYYLKDEELKRIFQKFDVKEARIARERNGTSKGFGFVDFKTHEDQQKALQFDGKEIRNRKIRVNVAFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVZ8</accession>
    <name>A0A9Q0LVZ8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General vesicular transport factor p115</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_05123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVZ8"/>
    <dbReference type="OMA" id="ESASRYC"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="860" mass="99962" checksum="FA3B074E2EA9FF93" modified="2023-09-13" version="1">MDKAYESEIDEQTIENKPNHNNSEKSKNKKRKKNRKKTKSKHSKERKHKEKHKRKHDSELQSEENQVFNGNDYDNIYISNNEDENQFVQIQQQQQQQEEEEKQQKKNLNLIYQSDFESNSSEKENNNENINENINENYNDDYNTNIQSIQEMKIDVSSDDRNSKSQEKSQNDSKKKNKHRQKDTPAKKIKALLNVHVPKREKGYIYGAKILQEQKKSLTKKEIVKIAIQKFPAIWNCYKKIYPESVAKTNFGNLLLQKGNSKEPRFIFDSKTLRYSLNEAYHQSELDKTNSKSKEELEEKSKSKSQEELEEKSKLKSKYKSKSKSNSKSKSKSNSKSKSNSKSNSKSKSKSNSKSKSNSKSKSNSKSKSKSNSKSNSNSKSNSKSNSNSNSKSKEKSNSNSKSKSKEELEEKSKSNSNSKSKEKSKSKEELEEKSNSKSKSKSKSKSRSKEELEEKSKSKSNSKSKEESRSKEELEEKSKSNSKSKSKEKSKSNSNSKSKEKSKSKSKSKSKSKSKSKSKSKLKSKPKKKSETSKEESKKTKSKNKGNKHKKKSGGEKLVKLLAQRNIVRKPGWIYGQEAIRSYGKPIPRMKIIKKTQELYPEIWECYQEAYPPNTRSSNFGRFILPSNYQKHGFTYNRNTATYGLSEWGSQLNDYENDNDNDNDNSKSSDESSDYSKNYSSNQNVEFPKKSQIRKLRSQKRKKKRKNRKKYRNHKLSSTSSSLSSNTSSEDSDDESLSKEKKKKKNKKDKKNKHKEKYKRKRRKSKKHSHSHSHNKFYHPYLVTYSDDNTIVLEQDDTGDLMMTAYQILAELDFQPETHKKIFNQITFGNFRVIDLLMKIRNNPLNKHLLILHLLLLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW74</accession>
    <name>A0A9Q0LW74_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fmrfamide receptor-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW74"/>
    <dbReference type="OMA" id="FCTENNS"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="744" mass="89505" checksum="3CAF02B8BE6B1F32" modified="2023-09-13" version="1">MIKKNQLKSYRKKIHESQQPVILFLSNGVIIEANKQAQILFEVPNDSFLLKESLSNLTVEFQDIPKKNTKEFIQDLLDAVSQLQSGTIDVDFQCLTAKKNPIFVHVFITTINLSGSKAIECVFTKPSERMKQLEEKAAKKTKDYKQEIENIKLKIKKLKFEIKNLESSDMKGSLQMKYNAMLERLKTKNKEVESLNLKIDSLKMQLGEKENNKLKEKIDELLEKKQKLFEIIKTRWVTERKREQFQHLLNQETKKSKKYKRELDYHKQLFEELKIKKKNLEIKSNEFIKSLEPDSDFKESENENQNQNQNQNQNENQNQNQNQNQNENQNQNQNQNQNQNQNQNENQNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIENQNENKNENQIQNEIENKIENKIEIENQNENKNENENENQNQNQNQIENQNKNQIENQIENQIENQNQNKNQNQIENQNENQNENQIENQIENENQNQNQNQNENQNQIENQNQNQNQNQNQNQNQIQNQIENQNQNKNQNQIENQNQNQNKNQNENKNQNQIQNQIENENKNENEDKNQIENQNQNQIENENENENENENENENQIEIENENQIENQNQNENQIENQNQNENQIENQIKNQIENENENENKNQIENEKMKMKMKMKMKIKMKMKMKMKMKKIKYLKLLKKYPKKLKKKIEAVVEKKEEKENYEMISDNEEIEMRSESEDELEIEVEKYQNEIIEIQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWA6</accession>
    <name>A0A9Q0LWA6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000012">
        <property type="protein sequence ID" value="KAJ5080162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWA6"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="237"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="428" mass="50946" checksum="144C590472650F6A" modified="2023-09-13" version="1">MKEYQENKMILQNVSCSILSSILNYFYSGKIEINLENAFEILFFSSKYLIDELIEISSNFIKKNFQIEITVDVLKLSDSMNLNNLMDFSYQFILDNFDEFIKTPFFLELEENHLNSILSNDEILVNEFEIFQSIIKWGKHKLNLNQEKEIEKEDKERFQIQISNIIDKIRFIDFSEQELEDILKTDLIPNQISEKLIEFQKLQSQKKKKKLNKFIQDQNQNQNSFIFKPRIRFDSQIIQEIKHFKKLKKWINDDKFFFQMKKQFSTKEDGFSTKKWHKKCDNKGKTLVIIKTKDNFIFGGFTKVGFISDKTKWREEDKNAEYGWIFDSDAFIFSLRNDKGDREPEKFTIKKNAEKFAVWYHLKSGPSFGGSFAGKDFRLYEDFQSGYSNFGISYNRPDGIEYGTNEAESYLTGSKNKWIVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX14</accession>
    <name>A0A9Q0LX14_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_13997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000008">
        <property type="protein sequence ID" value="KAJ5080552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX14"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="240"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="294"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="464"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="621" mass="72622" checksum="CC3F8DAE276E0EAE" modified="2023-09-13" version="1">MKKKKKNENENENEKQIKQISSGNFSTIFLFKNGKAIEYLRDSNQNPEKIQIENIQKVSVGHENEAILTLEGNVFAKGKYINSKNPKEFINISSLIEDTNDRVIEDIVSGYSSIYLLTSNQNVYGIGSNGWGQLGLHYETLQRTEKPILMMKNISKIFSGNTSDCIFLLNSNQELFGCGYNYHGQLGLKEAILQAKVYKLTQFQNIPKGKIIDIKGGFNHSIMLIEDEDENENENENPKRRLYSTGDYKSNALGKAQDTKIFTEIKSPLFENDEDNILKISCGQYHNLILTTNGKLIVFGNNEFGQLGTGDINHQPTPIQIELPKLRFNENISNYHVSCGNNKSFLYYSPHSFSNLEEDFIKLFERKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPILYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIEREEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNESFQIFEYWIYSNQIKDEIEITQEIIEEIQIGIDYFQLNQTYPNLFDLLINKFNNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQIQIQIQNQNQKKNKEKNCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX26</accession>
    <name>A0A9Q0LX26_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Spermathecal physiology variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000003">
        <property type="protein sequence ID" value="KAJ5080703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX26"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF99">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN GACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5080703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="536" mass="63856" checksum="DD6B140362C5E453" modified="2023-09-13" version="1">MKAVFGRSKGKVFGMKLDPNQPVHPFVQSCIEYIRGNGLTREEIIFDSFGVDVVCSLLKRYIQDLQVPLLPLNHFMQILDYSPNRKVRAISEIFPKIPSQNQVLLFSILELFSDIISKEQQNLMNIEKLSSIFAPLILRFEKGMENKFADHFNIENQNLSSVISVLIQNYKKIMRKTILRKNSKNNINLTQNTQMSESIQRSNSSQSVKIQSDLSDNEQVQTKVSRKQLKKMEKEDKEEKERVIEMLEKELTFLKKQQFALKERNINKFEKIRKRTNEQKKLFDDFTKQIQDHHTQKISDLDQISNLAKQSEEIDEICKNLEQECEILSKKIEEKEKEFHNSSEELKDSRLKFEKFIEETNFQIFRLQFDYRWLLEYRSQLERIQQNFAHEIRESIENEKNAKIQSIILKQQIRSFGSKIPELQKNYDEKKQELNQQERDLIDLSHALNEERERMAKIYNENESEIARLSYIYNNKIQQNDLLIKNQDLLDSEFKFSTEFLPQLEQEVQKAQEFSDQQEKYLQILAIHYSKLNQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LX28</accession>
    <name>A0A9Q0LX28_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LX28"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052824">
        <property type="entry name" value="m6A_RNA_Methylation_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13585">
        <property type="entry name" value="CHASCON, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13585:SF19">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1253" mass="152173" checksum="9481BE476DE619CA" modified="2023-09-13" version="1">MKQIKHDKSLELNEDIYKKIRFLSNTIDIQEEEIYIINQIENENQNQKENQNQNQEYILDSGFKYFKIKKENQKKENEFIPNFKNQNQKEMEMEMEMENEMEMENQNQNQNQNQNQNQEYIFDSSFKYFKIKKENQEEDDEFIPLEIGDKNEKEMEIEEEKENENDEFVKYQIEIEEENEIEKENQDVDDEFISDEFENEKEKENENDEFVKYEIEIEDENENENENENVDDEFISDEFGEEDENQNENQNQNQNQNQNQNQNQEYILDSGFKYFKIKKENQEEDDEFIPFEIENENQNEKEMEMKMENQEYIFDSGFKYFKIKKENQDQNENQNQNQNENQNQNQNQNEKEKENENQNQNQNQNENENENQNQNQNQNENENEKENENEIENENQNQNENEIENQNQNEIENQNQNQNENEIENENQIENENENENEIENENQNEIENENEIKIEMENNEYIFDSDWEDKQLEEIIAKKLIYKTKFQINLITEENLQQIEKEKKEEKEKKEEEEKRIINNSRLIQFTNPPFNLEKMNQLFNIRNQIFEDPSLLIQQFPEIRIFSLQNEGKDFLIYLFGIIYQKEGSGYLLKFIKENQFKQTKSIKNFIDSHFKLLINNEEKEEVQFISKKISNMEIISPQIKQIILETHKIILQKKIKPFIHLNGIFEMLTKNEEIKEIKDLEDLIKTYWNGFESIKDDLKISQEKKELIVSLFSNTIYPIINEYPKRNPFVTISGIDPIDFRIIRLMITSFFLSCLINFDTYYHPSINFKNYFVSNQFSSDETYNSFAYYNQILVKFSEETQKQEKYNKNSFHKNIEEIRKKNHQDILNLIQTNPIYQVDLIQEITKPEIEKKWIFQNFGSKELFQIFDLINFKKNQEKKETFALDFFFENLEELKFLNLFPQFLEISSIIFDNLKNQNQNENQNEIENFIECIYSKNINSHKNYYHFKIFWDICLKRIKILTSKKLDQNFQIFMLIENMIDYTIHLQNQLLKKAFQIFQIENQNQNQNQNQNQNQNQNQNQNKNQNQNQNKNQNQIENQFIISFPIKMEQIQSIPILNINSEKIKQKIINSINSKLLADIESKIFSIIQEKIKNLPKKEIIFQKEFKSKNQNQNQNQNQNEFQKFLETGKDPNDIKIQHPKIDLYFVDPKNIKIDLEDLIEFAYEVEFYLENNNNQNQNQIEKENENLNDPYIDSDIDSRQVPKNPYDNNGKYWKFFDPNSIPVPKPRISHKIFRNKNQNQNLNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LYM5</accession>
    <name>A0A9Q0LYM5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000011">
        <property type="protein sequence ID" value="KAJ5080235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LYM5"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="175"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="389"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="480"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="585" mass="68499" checksum="F19A3FF7828213B7" modified="2023-09-13" version="1">MNEIIFFGANREPKIFKNKPYDIKKPIQFRFGNENENGKQIKQISSSKDYSIIFLFKNGKAIEYSKYLSQNPSIIQIVENIQKASVGWQNAAILTIKGNIQNDRIIEDIASGFNSIYLLTSNQNVYGFGSNDFGQLGLDSETLKKTQKPILMMKNVSKMFSGNFSKHVFLLNSNQELFGCGNNEYGQIGLGESVTEKEETKIQNLTKIQNIPKGKIIDIQSGFNHSIMLIENEDENQNPKRKLYSCGNYQYNGLGKNKHENTKRELYPFIQYNKQTEDYHEFTEIKSSLFENDDNILEISTGSNHTLIFTSKGKLIGFGKNHYGELGIGDTNYQEIPIQIELPELRFNEEIYNYHLSCEYCRSFLYYSPPSFSNLEEDLIKLFRRKEFCDISFKTENGEIIEAHKLILKYRLNQNQNQLEKLQEIISNKSIKESNQIFEMIYSNNSKINPKLYYEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZC6</accession>
    <name>A0A9Q0LZC6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000006">
        <property type="protein sequence ID" value="KAJ5080625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZC6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5080625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="134" mass="16341" checksum="59346AAA5CC189F3" modified="2023-09-13" version="1">MWKWKRCNLSSIEKEMELKYHLEKEIKTIQLDILKELNSITTKYHMVHVGRLLYREIIPALKNLVIQNGFFFYFTFCQGCLKPKKKKFLLKPQELKEWFSNEKEWKIHYHIESELISDGRFVSFILVEKLKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZD4</accession>
    <name>A0A9Q0LZD4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000014">
        <property type="protein sequence ID" value="KAJ5080075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZD4"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5080075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="497" mass="59050" checksum="0016AADE996F8337" modified="2023-09-13" version="1">METYSNLEKLSNDLKNLFQNQNQNQNQEESYFDFEIICEQNKISFKTHKSILSSRSEYFKNLFKSKMKEYQENKLILQDVSSSILFPILNYFYSGKIEINLENAIEILFFSSKYLIDELIEICSNFIKNNLQIETIVDILKLSEAMNFNQLLDSSYQFILDNFKEFIKTLFFLGLEENHLNSILSNDEIIINEFELFQSIIKWGKHKLNINHEKEIRKETLQNQISNIIDKIRFIDFSEQELEDTLKEDLIPNQTSQKLFEFQNLQNQNNTKKLNQFIEKENSLIFQPRFKLDSEIIQSKEHIKKLKEWINDDDFFSKMKKGFSAKRDGFSSKTWHKAVDDKGKTLVIIKTKDNFIFGGFTQIGFFPKDRSKWSRDYTFRNYRFGRQNDPNAFIFSLRNDENDRKPEKFTIKQDQKLFSIFSHLDYGPYFGCGQFFGYGNDLPDFCLYSDFNKPGLSNFGHSYNLPNEISYESNEADSYLAGSFNEWVIDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4W8</accession>
    <name>A0A9Q0R4W8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_12849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000126">
        <property type="protein sequence ID" value="KAJ5067497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4W8"/>
    <dbReference type="OMA" id="EMAPIIL"/>
    <dbReference type="OrthoDB" id="5982664at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022074">
        <property type="entry name" value="DUF3626"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12294">
        <property type="entry name" value="DUF3626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5067497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="391" mass="45323" checksum="F8F8DCEC5C673341" modified="2023-09-13" version="1">MEIQVQIGKKKHKISVDDLETLIGIIQTLPNAPSNFRLMIGKPLRETKKFSEIKAAKIVVVEAKAAEKKVEEKSTTETDDSDTNNEDSDREIDGTDDDEIDSYSEDDLFEEDNSKVLSTTTYDPNDYDKTKSFLPPVEEVEALSLLNPMQAEAMKYVVEFSKKKSEQEYPNVLKRAKNLHFKEEELQRTLLYIRDEAPINVHFDYAQTFNALMKDKHYRNLFETGYGRGGNDTHSRVTWEDQMFNKIYHDSKPFDRVKYGSLNIVNDPHGVKCVYSYGDSFLVLKKVRLRTTFTSKDSCTNPQLACCEYYCHVLSEFSDQELKAVMEVANKKVQFHDSNVMHTFKETQIHGPIILSEHLVSIVMNPRYKQYEKEVDRFAQKNNCKVVWMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5B9</accession>
    <name>A0A9Q0R5B9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_13243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000134">
        <property type="protein sequence ID" value="KAJ5067093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5B9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="542"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="577"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="680"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="714"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="748"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="782"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="816"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="849"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="884"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="918"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="952"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1186"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5067093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1277" mass="145879" checksum="93FA1512F73BF020" modified="2023-09-13" version="1">MNIFEIIEKNQIEKLKTFETNLKEEDNILNFAIIKKVSIEIIKYLIEKGIDINSKDIKGKTPFHFACQNSSIEIIKYLVSKGIDINAKTNQDESVLHFACKNPNISIEVIKYLVSKGIDINAKTNQDESVLHFACKNPNISIEIIEYLVSKGIDINAKTNQDESVLHFACKNPNISIEIIKYLVSKGIDINAKTNQDESVLHFACKNPNISIEIIKYLVPKGIDINAKTNQNESVLHFACKNPNISIEIIKYLVSKGIDINAKTNQNESVLHFACKNPNISIEIIKYLVSKGIDINAKTNQDESVLHFACKNPNISIEIIEYLIEKGIDVHAKTNQNESVLHSACINSNIPLEVLDCLVEKGIDVNEKSYNYKTPLHFACLSSNISIEVIEYLVSKGIDINAKTQENFSALHFACQGNSSLEVIEYLVSKGIDINAKTNYGQNALYFACESNPKYEIIEYLISKGIDINAKTINGSNSLHHICQYNPPIKILNLFVANGININATTHLNITALHIACEFSSSLEIIQYLVENGADINAKATFGDSILHSLFQNPNISIEIIEYLVSKGVDINEKTDQNETLLHFACRSNLSLPIIEYLIEKGVDINSKTNLNNTALHIAVEYNRSFEMIKFLVEKGIDINAKTSYQNQTVLHLACQNGTPLEIIKYFVEKGVDINAKTDQNETVLHLICQYSASPQLIDYLIEKGVDINAKTSENETALHFLCQNNPSFKLIKFLVEKGADINAKTDQSQTALHFAFQNEVSIEVVKYLIEKGADINAKTDQNQTALHFAFQNEVSIEVVKYLIEKGININVKTNQNETALHFACKKYRSYEVIQLLVEKGADIKAKSGNQTALHFACLNLKPSFEIIKFLVEKGVDINAKTNENETALHFLCQNIPSFEIIKYLVEKGIDINVKTSSHYTIFHSACERQFPLNIIEYLVEKGADIHAKTRRNENALHLTCRQNVSIEIIEYLISKGADINSKTKENETPLSISIMHNKTQNIQFFLKNDVDIYDLQEREIKKEFVDSFLRVYSFNQDLDILLNSNDNFSDLSIQSNDFAKFKVHKLILLTRFNNNDSLLQKFINICSQKPKEIVKLALNFLYTGFFDFSKIIDIFTHQSKQNEKNPIYYFWRDSQEPKLILKEIEENEKKTREFFQEFLEEFDSKKGRKGILKDFHKLYQQESTKDFTIIVEEKEIKVHKLILLLRSELFKGMFLNVSDSSNQVHDYSRKSFETIHQLIYFLYHDKFDETKEINRKEIQNLKDFYQLNSKSMIDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5C8</accession>
    <name>A0A9Q0R5C8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_03270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5C8"/>
    <dbReference type="OMA" id="MRIRIKY"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5066926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="475" mass="57005" checksum="BF1D6DD3B5026242" modified="2023-09-13" version="1">MESQKIFVGNIPPDISKTELHHYFQRFGNVEFSHLVYRRNLPKFAFVKMKSVEDMNKVLGMKNPVLRGYALKISFAKPRATKESTCIFPIYMNRWKIAAPLQEPSKKSVIVSNVSNSVNEEELIRYFSRELRTSNIYCSLKKEKFRSFAYVTFESENIQKRALEMKHPFLQGRKMRIRIKYDNIVDDSQENENQNQNQNQNQNQNQIQNENQNENQNQNQNQNQNQNKNENQIQNQNENQNQNQNQNQNQNENQNENKNENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNENQIQNQIQNQNQNENQNENQNQNQNENNENNQNQNENQIQNQNQNENHNQNENQNQNQNENQNQNENQIQNQNENQNPNPNINQNQNQNQNQNQNQNQNQNQNQIQNQNQNQNQNQIKIKIKIKIKIKIKIKIKIKNSNIKVFLILIMKMMKIQISFFFVFFSFFNKKQIFIIETNFMFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6L0</accession>
    <name>A0A9Q0R6L0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000115">
        <property type="protein sequence ID" value="KAJ5068441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R6L0"/>
    <dbReference type="OMA" id="DIICERG"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="905" mass="106296" checksum="3271CD172B45275A" modified="2023-09-13" version="1">MVEEETKQRLKNLLRSYYGEIQKDDNENLQQSEPGILNINSGLFDSEKYFQKLLQENSLSKLINIDEEIINELNGLDTNLQNLVMDNYNKFISGTDTIRKMKSNVENMESEMQKLQEKINEIEKISTEISTNLEPKREKIEQLTGIHRLLNKLQFLFELPSRLNKCLEFEDYSQAANYYIASKRVLNQHQNLPSFANIYNECNEIISKLKQILFKNITTRKNKESAELLLILESPLNIVRKSFIDFRTQQIHAIITQFEKEKIQEKDQEQEDELLTFIEKFREALFHPLTMFCLDFHDLFLDESKNYIKSTNTEESREKLREQILKLIDQYIALIKPRLLNPAVNPLTIRTALENICSAFSKMLSVLSDNTVTRYFKKFIQQVLKFHIGFKFILLEKDFRHKLNEMNKNFISKMKTKDDQKEKQIKIKNENENENENENENENENENENEKDLNKHNNLQKKNPDQYLGNVDQICREFYQYLIKQIKTIPESISPFFEMEMLTQENEFENESVKSNQPSLLIEHLPKLQKLLQIQIRTFFTLVYELFQTSINKNKSNPIVHFPVKSPSINNQSNQEQKSFENLKIGGNEKNEQNKLIDPKKSNSMEEIIKPSSVSLYLVFSKLCLLISDKLVELVGDFACLIDEKGYSIKSYISSEQAKTKEDEEKITKLLNGILPSVHLSRLISEMRHKAKQFAHQYVHRLSQDVSQMIIKSIETPDWLNFHEPKNIRLAIQLVGEELIQANSHISQIFPQFQKTRERRNSDTSSWSSRTSAMLRSEKTFSISQHENRQLQIIESNIDRLFSKKIKLFGEVDYYRDSIFEAIVKNIMKTFFETVRQKTFGKFGFQQIQVDLTYLRSCIDDLVDSSILNPLSDEVLTSAVERCLEPSSLEQVVIDLIINEKKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R6N2</accession>
    <name>A0A9Q0R6N2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug-resistance like protein 1 isoform i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">M0811_11752</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000106">
        <property type="protein sequence ID" value="KAJ5069267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ACAQWFH"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="862"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="942"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="95"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="487"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="826"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1141"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAJ5069267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1396" mass="159233" checksum="BC80E18000E08B13" modified="2023-09-13" version="1">MKTEKISHVPNKEIKANIFSRLVFSWFTSLAKIGYKRPLIQNDLFELRPQDFCSKITGELEPKWNEEKKQTKPKLINSLKKQFKKPLYLAGIPKFFASACSILNPILLQQLIKYMSDSSASQSTGIILVLFLFLSGIFRTILDNLSLDQVIKVGFRARSGLTSLIYRKSLLINRKISDQQKKKQEPKKEKEEEELKEKELKEEEELKEKGLKKEKEKKLTKKERKALAEKQNEEQIKSNLSSTGQIVNLMSGDLTKMEETALFFHVIWSAPLQILVCLALLINLLGAAALVGFGVLILSFPINRFIFKKFTKKNILFMVQTDSRIKIINELLQGIRVIKFYAWEKIFKKKILDLRDKEISILKKILILRVSFTVLYTMLPLLTAVTTFVVYGSTGKKLTAEKVFTSIALFELMRVQLLFLPWTIVSFSNFKVSMKRIETFLLSPEIPEENREIHRQRVDPNSNEVQITIQNGSFTYDTNNNQNNNNNNEIDIKKEIPLEEQKSQKQVLLKNISLDFEPRKLTMIIGPVGSGKSSLLAAILGEMVQLQGKTTIKGSIAYVSQEAWIQNGTVKENILFGHALDKKRYNQVIESCALIPDLAVLPAGDSTEIGEKGVNISGGQKQRISLARAIYSNADIFLFDDPLSAVDSHVGRHIFDQAILGKVLQTKTRILVTHQLQYLPHSDFIIVIKDGEVFAKGTFEELIHKGVDFSNLLGDQEKRVDESETSDDDDDDDILDENLNKKNKKEKIKWIDLQPETESDPFGDDSDVEIDIELPPNENREKEVSKEKVENKKGELVKEEEREFGAVASFYYKHYIKVAGGCCILFIVIVSGIFRESFRVAADYWLAIWTDGTIFHDKTDRFYIGIYVAISCGMFLFAFIFSAIWIFASIRASKRIHNDLLFAIARAPTRFFDTTPIGRILNRFSKDVLDTDLFLSANFENFISVGISLFAIFVVIVSVAPYFLIPLVVILYIYYKFMQYYRSTSREIQRLQSISRSPIYNNFSETLTGVSTIRAFQKQKEFIEINDSRVDENTSAIYCNFSSNRWFGVRVETISSIIVLCTSIIIIAQKDKLNASFAALGLTYSLQVTILLTWLVRYGALLEQQMNSIERCVEFSSIESEKPEIIPQHRPPKNWPNLGKIQFNKICMRYREGLPSVLKKVSATIQPQEKVGIVGRTGSGKSSLMLSLFRIVEIYKGKVEIDGIDISQIGLKDLRDKLAIIPQDVVMFTGTVRENLDPTKQYSDERIWEILEQVHLYEKFQGLEEKLETKVTEGGDNFSAGEKQLICLARALLKHPKILVLDEATSSIDTETDSLIQKTIREQFKDCTVLTIAHRLHTIMDSDRIMCLENGKIKEFDKPSLLLRNPNGLLSQLVHKTGPKTEAHLKRIANGEESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R740</accession>
    <name>A0A9Q0R740_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_12337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000116">
        <property type="protein sequence ID" value="KAJ5068354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R740"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
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    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="205"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5068354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="391" mass="46589" checksum="5045A0E5306771CD" modified="2023-09-13" version="1">MDNNNNNQIQNANQNQNENEMKNLEKKVTKNLIKNYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSSFFNEIEKLKGKKEKEREIEKKRLFHSFFSLFDKDSISKQDFDKLKQFDIFLPKSFLIENKEKEIEENQKEIENKFIQENQQMKIEIEEKDKENQQMKPIFDKYQQKYQKYLEFEKKLEPIKTNFPQFSETRIITEEEYAKKLQEWINDNDFFSKMKKGFSTKRDGFDCENWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGWTNDKSKWREEDRNRDDGFIPDSNAFIFSLRNDKGDRKPEKFTIRKEQEEYAIFYNLEVGPTFGSDIFFIFTLATGYSNFGLSYNLPNGIECETDEAKSYLAGSFNKWKVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R777</accession>
    <name>A0A9Q0R777_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R777"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="243" mass="28491" checksum="C4CB4D6CCE839776" modified="2023-09-13" version="1">MKILLIGIIITIIIGFVMAIPCLIIGTKNRNYSDWKIDFIWILIFNIFWIIITFITSLSLILHDFENFFKNLDESKNRVMITFTLIPIIFLLSWSIYGFVIFVDNFDNSNSRIITIKIASTIIFGFGMAITCITVSIQDKNCSDFTNFFTWVIVFNIFWILFCFLFPLFLFSDLEEPLPLGVFLNILIYIFLFAWLIYGWVKYTSWGSSDSSCTHFRDILLSESIIYSFCWFFSCISISILLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7J3</accession>
    <name>A0A9Q0R7J3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7J3"/>
    <dbReference type="OrthoDB" id="434411at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF4">
        <property type="entry name" value="PHR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="487"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5070167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="592" mass="69016" checksum="8B705BCF1B9DFCB9" modified="2023-09-13" version="1">MNDCLFFGRNQNPILIKNEPNSMKNPIQFKFENENENEKQIKQISSGSFSTIFLFENGKAIEYLNENDSNQNPEKIQIEENIQKVTVGYQNEAILTIEGNVFAKGKDINPNNLKEFINISLLIEDKNDRIIQDIVSGRFSIYLLTLNQNAYGIGSNEYGQLGLDSKTLPKTEKPILMMKNVSKIFSGNSSYHVFLLNSNQELFGCGANRDGQLGLGKSRKRETEIQKLTKIQNIPKGKTIDIQCGDSHSIMLIENQNQNQNPKRKLYSCGYWIYNGLGKRFGEDTYEFTEIKSSLFENDDIILEISVGNAHSLILTSNSKLIGFGYNSYGQLGIGDIYFFRLIPIQIELPKLRFNENIFNYHISCGDYKSFLYYSPFSFSNLEEDLIKLFRRKEFCNISFKTKNGEIIEAHKLILKYRLNQNQNEIEKLQEIISKKSIKESNQIFEMIYSNNSIINLKLYSEIKEIINSNEKIEETIKRIYLNENEKDFIIERKEKEYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSDKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R825</accession>
    <name>A0A9Q0R825_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein rab-11c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_11210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R825"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000274">
        <property type="entry name" value="ras-related protein RABA5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5070181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="284" mass="32402" checksum="9662CEA8506AB2E3" modified="2023-09-13" version="1">MSDKEITKNEDENVKQDEKQDEKQDEKDIENEKQDDNDNDKEKEKEKDEDEDKKSLSDSSDDGAHVIEDEMDERENFLFKILLVGDSAVGKSNLLTRFCKNEFDSDSKSTIGVEFSTKVVHFDDKVIKAQIWDTAGQERYNAITAGYYRGAVGGLVVYDTTNHTTFERAAKWIDEVFENCKQNIFVTLVGNKIDLKDRRQVSVEEGQKLAESKQLAFIETSALDSTNVEECFTDLLKRIYDVAKDKDSNFLENTANAEFVPTSALVIPEDTEKNPKSKKKKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R885</accession>
    <name>A0A9Q0R885_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_01775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R885"/>
    <dbReference type="OMA" id="HIDFWND"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="140"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="287"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="5">
        <location>
            <begin position="519"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5070794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="642" mass="77405" checksum="A1628C31FD5C26DB" modified="2023-09-13" version="1">MDVLDSLDPKERKKILKELKKQRRKQKSKEIEPNEGHKKKRTKKKRQKMGKQEEKVFGYTNDDNPFGDSNLTQVFVWKKKKEKELNKGIITEDDIIKEQKKKREELHNEIMKVKKAREQREYEKKIWEEEKARLERQEGLAKVLEMNKKDHEFHLQQAKYRTHIRIKEGREHPIDKLYKSVTLDLRYDIDTQEPYKLFEVLDLSSLEQLSEEIKTFIELGDVHKSSWIQLQIICEDEIRRARFRMAQEDSLIQQNQSNNFENSNHENFLQMENSKNQSNPQFLGFRSGFEYGVHESVKNDILEAITDKTFTELDALQMEVEDHMNSDDVGDIEYWEAMHSLIKLYKAKAFLREKHEIKLRKRLSILYEILEKEQKEKKEKNIQNENLNENQNENQNENLNENLNGNQNENQNEDIYSDEEENANIEILEKKYNKYQQTKNHTEKTQESTTSEYEKDDLIKGFEEFIANEDLTEAKDTSEDKPLNPLTLGDEYNNLEENEEDDDDLFTDEIQLNQQTYSWDNKYRPRKPRYFNRIKTGYEWNSYNRIHYDGENPPPKTVQGYKFNIFYPDLIDKSKTPFYSVEKTNSPEISILRFHAGPPYEDVAFKIVNREWENSRRRGFKAFFDKGVFHLWFNFRRYFYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8J8</accession>
    <name>A0A9Q0R8J8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000095">
        <property type="protein sequence ID" value="KAJ5070468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8J8"/>
    <dbReference type="OMA" id="KAHAISI"/>
    <dbReference type="OrthoDB" id="65740at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040121221" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="315"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="548" mass="62585" checksum="F5EAF36B3294EA4E" modified="2023-09-13" version="1">MNSLNNTFFNIFLLISFLNLLCKTQPPPNYPNKYRIKAFWRMPAANITQPILINYNSKNFYERFDYYSLDISTTIATDLLRNDSNQLYRVRIMNDTVTCSIINSSGTLELLPFLPDLYNEDWEEGQPTVIRGFPVRMWQKNTTIQNVVSIFTFYSDDQGLPVRFAVNGYDSLLKTHFDIYIMEYFLYQPNVNDEFADQINHTCEYSLQQDDRFPIPLEVISSSLQKIGLSNLDLDINNLKEKESLFSRGKILQENLKFIDEHNKNNPNFKLAPNQFIHMSKEEINRLILGNPKKHLIEDDSKTKQFESVEVIPGKPETFNWTDFDVVTPAEDQGMCASGWAFATTGVIEGAYKIATSTFIDFSEQTIIACSSTLSDSCLGGYPQDALAWIQENGIDESTTFPYIGIESYCLTPQTPSLIKIKELLSLPDTTFSKLSDFIYSVGPIATMMDASNLDFIFYKSGIYNTSQCKTNLNDLNHAVLLVGYGVENDTEFWIIKNSWGNFWGENGFARIVADQNLCGISTAPYGALLNFDNTFDHQKKEQKTKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8P8</accession>
    <name>A0A9Q0R8P8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8P8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="82" mass="9364" checksum="71F068BB1EEFFE85" modified="2023-09-13" version="1">MQKSLSVLLKIQSSKERKQMGIKKSGMKFEIISNQNEKTLDKSNSQIPQKKSSPSIISPRNTKTKMTRLKSARKLFLKADIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8W7</accession>
    <name>A0A9Q0R8W7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000098">
        <property type="protein sequence ID" value="KAJ5070124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8W7"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="293"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="707" mass="81828" checksum="ACCD86862FB0FC0F" modified="2023-09-13" version="1">MTKTQNTSQCINDLQSLYITHTYPKWDEILKTWGTNINDLGKYESCLEINKNQIVKLTRYCVLKTKFRDVDVSLGACLPFNCTESELNYFVPKIRSFLPIPENYPISVSCSIEYRKSISFLLIVLFFVFVGMTVVIGTFLHSRILKREEQENPNSNKHPKNLKPNSEKVEKSNDPEKQSLKDNDVLAKNEEMETQEKTSAEFMQLDSSLPMRNLIDNEETNPFEPNIQQEIQSSEEENQHNGLTQSKQGNQEKKKKSGTAKNNWKVEFFLQFSLLKNIPRIATESHNSFKVLHSLRVLSMLWIILGHTYSYFIATAAVGNILGAESLLKRFSFQFVVGAEFGVDLFFVLSGMLAVHSLLAQLKSTNGKVSLVKFYFHRYWRIAPLFLIVIWIGWKFAIQLGNGPMWKLYQESVNKPCSKSWWANAFLITDFYPKWENSCFGHLWYLSLDFQFYLLSPAIIFLFYRNRKFGYFSVFSLMILSFIITASVVSGYNISQSVAAPNSSDYWNKVYVKPWCRITPFLLGMILGFVLYERPENSSRKVRKKLRISLFLFAGFLMTITTFGTYSLYHSDDLNGWNKSENIWFITFSRFAFSLGLLILLYLFLAGYGGSILVFLSSDFWVPFSRATYATYLIHPIIMRTIEADFKASFYWSDSIIAVYFCGFSVLGFAAGFLLSLCFESPLMNFEKIFWEKVGRSLKEQNKNNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R932</accession>
    <name>A0A9Q0R932_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35683">
        <property type="entry name" value="YALI0C04136P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35683:SF8">
        <property type="entry name" value="YALI0C04136P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1510" mass="178666" checksum="E7A18C9E31D03794" modified="2023-09-13" version="1">MKLLTNFELNLTSIYQNSFNFQFKNNSKYKKDYFLFINLTQDLEKKQKNSSIKICFLLKSILQKINQSKIRNYNLKQYLIQSTLISFILRSFLFQKRLICQDFFQNGKSQKISRYIYLFSLNFLNKNVCLFHFYSTYGSKILYELFKEFLQIRRNITDYNENDNENDNENNNENNNNENNNNQNNDNQNNNNNNQNNNNQNDNNQNNNQNNQNNNQNNNNNNDNNDNNNNNDNNDNNDNNDNNNNNDNNNNNNDKNNKNDKNNKNNKNDKNDKNNKIEKIEKIEKIEKIEKIEKIEKIEKIDHLPNKKLQEYSLGRRRSSVISSFQEQIFQSAFQSLDFSNFILFTQFSKNGKPKYIQKQPITNLSSNFRLDSSYISINDQIKDQINEKIHQFISKNKAVFETQFKIGNSFEKGKIEFRLKNMRIKIKPNKEEIFEYEEEEQMLLVHTIKLTRLAFYANPKLIYVLEMNDVNSRDLLINSFIVFKKMYHFQKVKKVQLKRLNFVFVITPTKKQISKNYFTPFVMPKTQFFVEDGEQIQDSSLPNYNTMIYQVKTKYNVNILDSFGSVAFGSEIELYQVHFTIQTPSYLITRKYSLYSQLFPQNPLECRFFIDEYDFFDIQFPTQEMQNGFLLHFHKKRKYSSLFLYSWFKQNKPIFFDCLFYGKTSNEQFSGQIILECDKMTLKSYTLTHPLVNEETVIKSSIQEENNPEQEMRYKAAFFPHVLHSTSEKSLEYSSCIDIYVSSSKKTATTVKLDFEGKYQMEIDFTISKMAHLFVSKFKERQTNFLQYRMMHKIFQQEEYRNEHVFVPLKVDIGSIEDVQVSQIMILTGKTILIFEEKSLIPNVFLIKIFSIGKSANSCIIECKDNSNEEIKNLQIKFQNREIFLKFQNELENFQYFEENLRVNEVQMNEVFFSSPTLTKYNVNSLTGIKSPCLLALSTEELMLSYPKDMDLNQIQIENQNIFKISNTNIFPFDSPKEKQLKIINNMKNKEFVVEFANKESRIQFTTKFSLAKEKFPSKESEKSKFLMDFFEEENDIDKMRIYSTFFPLFRDSKAKNSSAVQLIFKGNLLRVNSEHENLVSLRIKKNIKLKRKGDEKYSIEVSQDHSTFNFIFPNESETNRAFNLLNQVKDIVSIPQTLKTTITQNERIFSSKVETKTDSFAIKFSHKSMDIPYDLLEFGSFDQDSQKLEIKLPNSQILKNQSAIITCSKPKNTTLLLQKLLILKKEYLRKKKHRTKKLYIDQEKFESKSKPKMKREGTMSFLESVDDNLSPETSQNSTPKLKRKRSLRFKLEEDDEEKNQIIDPNYEKNPPNENDHIFSISTNKFDIQFQENSENQEGILEYNQFDIVLISQNNIINKFDTLDPNLNIIESTNGIITISDQSSLVSFTSSQGNRKKFLENYNQFRNFFRITILKSFDENQVKKEANLQIESSGFIIVSRDLKIYQYSMEMSSKVSHHKSKPIVQLLVALDKMIFCKMQSRESCFKLIHCYQKAFSIFLENLNLNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9H0</accession>
    <name>A0A9Q0R9H0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beach domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000083">
        <property type="protein sequence ID" value="KAJ5072102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9H0"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="450" mass="52378" checksum="64F0E1CEDBF23433" modified="2023-09-13" version="1">MFYYLTYENLINFEKLKSSQDKKAIEVQIEHFGQTPVQLLRKAHPKRFPREKIMRMNLSTSIYWRMKELTQVKTFTIKICELPIIFIQFKRESGIVSFLGIPDKIITIDIERNLMDHSWSIFRRATQKENSIINNDPNSNENPNENLNQNSNQNSNQKKNHNNSNQNSNQNEKQDDLIRNFTFLTNSDKGLKKKIGVSFASDAHNLGNCFDSPENEDILFSCGYWDDSFKITNLQNRECIQSIIWHRDIVTCLKFNRNFLVTGSKDTTLIVWDCNFNSGKIFLDSPKNILCEHNDEIECLDINWDLDMIVSGSRDGTCLVHTLRKAKFVRNLYKFSKSVSMIQIALNGNICVYCQEDNMVTVFSINGKFLSQRVLNEKIQCWSLTESSQFLILGTDEGRVHFLFLDSLENFKSFSVGESIKSITLTKDEKYLLIGSEKGNIHIVLFYFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA35</accession>
    <name>A0A9Q0RA35_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_01596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RA35"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="566"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="716" mass="82300" checksum="58925BDAFC838F82" modified="2023-09-13" version="1">MSNSLNQLSNSPSQISTENSLEINNPENENLERTNSNTNLEAFNIKIRPKKPTNWKEIQTTGEIPLVTNYHTSAVINNYMWVFGGFQRGHGTRDLSCLNLNTFEWKSIKYNTFLEKTRRNANIGWPSARYHHACTVANNNLFIFGGLDGKKYYNDLWKFDPETEGFEKLSDNIGPCGRDCHSLVSYKNNLYVFGGVQDKSKLLNDLWQYNLETNEWFELKPLGEKPCPRHFHTGVVIGSFMYVFGGSNGQVRLNDHFIYEFETNTWISIANSKGKIPQTRRNHTAVVKDEKIYICAGYGKAPLNDLYVYNTDTNYWSLIKDEPTFSPRHYHTSVIWENKMILFGGWNGRQLQDLHVYSIQEKPLIIEKNVIKNDMKTLFEKQEDCDINITAKDGFIGAHLCIIQARLNNWNEIKNREDEEIAITFENYFANQPLSTIKILMIFIYTDEIELEKLTQNQITDLVIISSNIGLSRLKTICENHIISSISKENFVYHLSSKNKEVISEHGTSLTKLSQETLIELFKTTTANSPIEISEIEVPKSMFFQNLSALQSEIDSHNAIEVAICAHKAILTAHSKRFGQEIFSEQNGPEIYADKTQRSVYTLRALIKFLYSGRVDHIQSNPQIALELLGAVSDYDLSTYELENVCSNIVKRSVNLNNALFILERSYETNSIDLKNYLIRFLLNNKQQVFNLPSFSNISNVSLLHEVIKELISRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAA8</accession>
    <name>A0A9Q0RAA8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein aardvark</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_09140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAA8"/>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056597">
        <property type="entry name" value="ARM_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23744">
        <property type="entry name" value="ARM_LRRK2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="223"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="269"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="494"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="LRRK2 ARM repeat" evidence="3">
        <location>
            <begin position="722"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5072927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="917" mass="107561" checksum="64160F67C08D6D7B" modified="2023-09-13" version="1">MNKFINSSIVTTRGLKCLSSFSFQNQQNQNIISELNGIEMVIKLMNNFQYKNEIQQFGFEFLQIICANNKKIRNKIIELQGIELIKKGIKNFPDNQRIQLFISFLIKFLEIENEIFDYSNTNEVDQEENQIKNRILKGIEEVIKEMNESPTSRITQFYCCSALSYFDFQNEENKKKIKELQIIKVIIRAIINFKNNEDIQESITGALMNIVYDNKRNENEIKEMEVNERIISTMNKFENNQEIQENGIRCLLNLSFDNKENVNKIRETNGIERIISTMNKFENNQEIQENGIGCLLNLSFDNKENVNKIRETNGIERIISTMNKFENNQEIQRNGIGCLLNLSFDNKESVNKIREINGIKRIISTMKQFENNQGIQRNGIGCLLNLSFDNQKNKNKIRKGKGIEIIIQTMNNFKENNQEIQRLGCGALWNISIDNEKNQENIKEMKGIKTVIEMMNKFEDDEEIQEYGCGVLNNNIIIMNENNNDISLEKEITETQVIERIIIAMKLFTNNKEIQYQGCCCLKNLAINNNNNENKDKIREKKGIEIIIKMMNNFPEIQVIQNQGCETLWNISINNSINQKEIREMKGIETIIQAMRKFPNNKEIQENGCGSLFNIGFENGNETEIEKMKEIGIILPAMKQFPKNKIIQYYGCRILLNSSFNNQENQEEIREMKGIETIISTMKEWINDKEIQYQVFDALNIISYKNKRNQKEIRKLKGIEIIISIMNKYSNDKGIQYIGIRILWNIGFDKKNREVIGEMKGIERIISAMKEFENNELIQEKGCGALMNIIFDNNNNKNKMREIEGIKTIINVMNKFPDHEKIQENGIRTLFNCIFENEENLKEIKRMKGIETIISTMKIFEKNEEIQESGISILWDIIIKNQENKEEIERFEIQKLIQKAIQNFPKNETIQKWKNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RAN9</accession>
    <name>A0A9Q0RAN9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nad-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000080">
        <property type="protein sequence ID" value="KAJ5072673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RAN9"/>
    <dbReference type="OMA" id="PQTAWLN"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="365" mass="41370" checksum="570AC71430B3E1CF" modified="2023-09-13" version="1">MSKPRVLILGGTGFIGRNLVKYLVENDLCSKIRVIDKVLPVTAYFSKEIEEAFQKVEYKQGNLGNEASIKKCFDDPDGKFQIVFNLAAETKYGQSEDVYQEKVLDVAKKCAAQAKEVGVERYIEVSTAQIYESSKKPSDENAKLKPWTHLAKYKLQAEEALKQMQVPGLIIVRPAIVYGPGDIQGISPRIITAAVYKQLKEKMKFLWSGDLRMNTVHVYDVCAALWLISQKGKVGSIYNLADKNETNQKAVNVILEQIFGIETGFAGNMASTFAKMNMKSVTEDVNEKHLTPWAELCKQHGILSTPLTPYLDQELLYKNSHCIDGSKVEKELGFQYKYPKMTKELVQEQLDYFLKLNLFPDLWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RB60</accession>
    <name>A0A9Q0RB60_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_08375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000072">
        <property type="protein sequence ID" value="KAJ5073811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RB60"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5073811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="377" mass="43841" checksum="5FEFCD9399232F12" modified="2023-09-13" version="1">MISFQDLKNKLDKKYNNFYSNDELTHFHDSETIIIDNGSSTIKTGFGGDDTPRAVFPTIIGRPNKEKVVTGSPSKDYFVGDEAISKRGILKLKYPIENGIITNWDDIEHIWHHTFYNELKILPEEHPLLMTESPLNPKANREKTTQIIFETFNIPNFYLSNSSSFSFICFRKNNRNFLRMNIAGRNLTNYLMKILTERGYSFITYAEREVARDIKEKLCYVPLDFYEEVEKDKNSYGIEKNYELPDGQIFSTGDERYRCTEPLFQPSFIGLSQLGIHEIIYNSIMKCDEEIRKEMFGNIVLSGGTSMFEGIKERIEKEIKQLSPKDMKIKVISPPERKYSVWIGGSILSSFPFFKNITISKEEYKEFGNSIIHKKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RC56</accession>
    <name>A0A9Q0RC56_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Filament-like plant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RC56"/>
    <dbReference type="OrthoDB" id="10656913at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="259" mass="29776" checksum="6506A43BD1E54B7E" modified="2023-09-13" version="1">MGQKATKTTKVSRGQLKSYMKMIHYSKEAICLVKPDGYFIDFNQPFMEIWEAKSREQLFALTPGILAPPFQPHMGMDSQSAMEKVIGTAIKSETGFHDFDFLQTTVDGKEFWAHVWLKFVRVDKQDACQAIMKRIENPMESYQKQEISDKYLNLNLQNDTSDTSETPSLAEMTRRFGNLEDKSKELKKASENLKSLVLPYSDEKTQEISKSIESVLSLSQRNSEVNKKITQAQNLFNSLKTKQKEFFDLITQISDLTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RCS6</accession>
    <name>A0A9Q0RCS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RCS6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="259" mass="30842" checksum="082841CECF6E7DC2" modified="2023-09-13" version="1">MYRKKVFELSNTSLLKSILCNKVFILLIALLIGFLLILFLSVRSIPNELIEMSKKMIQFENQLNSLQKKLKRYRDSQSNKTPSIDDPFSDFYDLNLYHYQNPYFYHTEEDTRFIKYERYEDRPKISKTIVSDNEILYHLDFESFYLDTPNFLDQESYDMFCDERDKPPMAPGDCEKFVSSMTTPYFTTGNETFVKNFSFDKLPECLETTTMNSFQKPTSQNVKHFEKLALITPARSNYFQHWIDHALSPLMQARPLYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RD55</accession>
    <name>A0A9Q0RD55_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_01014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RD55"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="294" mass="34384" checksum="3A6276F91AF33DBA" modified="2023-09-13" version="1">MIYNKESIPCIIGSLFGMLGSLLFILVYSFIKEIRDSARKFIFTLAIYDFFLAFFAFIPGHVSSDFCKFQGFMIALIFPAACCFIFLISLVFYLKICYGKNVDESKKFFIIGNIIVFFICLIAAIILLSFAKIKAGSAHWCWITKPEFEPVIYAIVWITLLAALVLYIIIFFKIRKNPKYPRAFQYKMFILGWVYVFTHIWTSIKRIRQIANPNVGDSIFLDIMQALFGPMLGLWDSVFFVLLDKRVRSFIKTKFKKRKYDELKVGLKENERNIEFSIQNENENENENENENDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDD9</accession>
    <name>A0A9Q0RDD9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDD9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="294" mass="33913" checksum="18BA73F742EEEBC0" modified="2023-09-13" version="1">MYTVELKIRKNAKEALKKTKIQEALKQPSEWFKNPYYFLAGGSASVLSEQINTWSDGLLKADKIPEMFFKSGLTDLLTELWKKFWVSKYHLSPLHTWKRGILIGICVAASRTFLTVVYNNIKQYHQSWVKNQEWQYNKPWEQNSKPFIPRSMLSTAMHMPIEMGIKPMTEGFLEKAAKDALFLASVQGFVHFNSDYIAPKIFNPKNTGWINHMNKTFFLGGLSTIEASLVSKPLEMAIDNFSKSKNKSSFSDICKSTLNVAKERTPRIAWKVFFYAKAKEELPKIYNSLTKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RDF4</accession>
    <name>A0A9Q0RDF4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab family gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_06121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RDF4"/>
    <dbReference type="OMA" id="FIKETTI"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001204">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5076541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="211" mass="24558" checksum="2301FE28725BDDDC" modified="2023-09-13" version="1">MSFDYMFKIILIGNSNVGKTSLIIRYVDNNFIFIKETTIGIDFRTKDTEIDGKIVRLQIWDTAGQEIYRNSISFSSSVYKNADIILVVFDLTKEESLYKIEYFLNEIENNCRTNPLIVIVGNKSDLIEEQLENVEEKIKEILNGDKFIFFKTSAKDGTNVNELFYEIAKKFKENQPKHYLKKEEENSNNIILQDAKDSNDKNKSKSQKKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0REL5</accession>
    <name>A0A9Q0REL5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intein-containing cell division cycle 14 isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5077292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0REL5"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030908">
        <property type="term" value="P:protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="604"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="759" mass="89650" checksum="7361FDFD7BE9B474" modified="2023-09-13" version="1">MLKRVHFFDFIKNRLYFFCSKIILDSSKSNDHYFTIENEFIYQPFANDFGPYNLAQITKFCEILFEKMNDPELTQKKIIFYCLDTPESFTNSAVLICSFMMIAMEKTPEEAFKPFEKIDKIISFRDASYLRQTFSLTVLDVLNGLYKAMKCGFYNFETFSIEEFVYHDKIENGDMNWIIPGKLLAFSSPRDFSNEYKPENEKITPSTDQKKKKKKKKESKKKFVQRNTLPSRFSRPLSPEKMMIAENLMKYYFWSLDKYVEHFQKIGITSIIRLNLPLYDSQIFIQNNISHHHLYYEDGGVPSWKIINHFLNIVEKEINIDDQSNLCDEENNSNLPKNNVIIDNDNKKKKDKNDIKNNNGNSTEKKGGVAVHCFAANTKILMSNFTTKKIQDIKQNEQVLGVDYLPKLVSHTIKGFGKLYKISRKNQKDYFVSKKHILCLLFNKKPHRFIDLEKKGKKMYFTFIYYDLHHNQQKRKIRIKKSTPFYPKYLIRACWANQTLFNSRNEYIGSDPQLKNFHIKKYELEKIKSIFCHSFLIMANYYRKGYAIEFGDSINITVENYMKKCEEWKKSHSGYKSVLVDNDLASEKGILKMNSKGNFVVHQLHKIQITDTKKKQFFYGFELDGNEKRFLLKDHTVVHNCKAGLGRTGTLNAIFLMKNYHFTAREAIGYMRLCRPGSIIGKQQFFLIGIEEKLHEMGKKKEKFIVRNPPKIPIEKLDVSFKKKDQLTNFSIPDPYLFNLDLKTNPHFWETFNKNKKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RES6</accession>
    <name>A0A9Q0RES6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_06881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5076019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RES6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5076019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="102" mass="11777" checksum="644607605CD1755A" modified="2023-09-13" version="1">MSIFSEETLKILSQVKIIYEDLNHSDETPPVQILIDWVNSKLKNLSPSKEIHNLKFDFKDSSILKLFLVALFPYQDFPELNKTSNNVTRAKKIIDQLSPNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RES7</accession>
    <name>A0A9Q0RES7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ccr4-not transcription complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RES7"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="485"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="597" mass="69880" checksum="149B261CEB947848" modified="2023-09-13" version="1">MANMHWNPNIQSRPTPQPHFSEQISYPISPHQNSNYIFDYSPRTNPENVQEDDNIPSLFQYDIAQKQNQNPPTMQQKYVHMNPYAESAYFVNQNNSANIPRNMNSLNSNSSPIRVQSPNNQQMTRSNPNIENYHGHSTHPQMSHMNHMNQMNQINSMNPMNQMQLNQMQLNQMHQLNQMHQLNQMNQINPQMHQQINPQINPQIYQQIHPQINSQMHQQIHPQMHQQISPQIHQQINPQMQPKINQMSTVNPINSMNQMNQINPNQFSQDTRYFNANPFDSEMIQTQDSYSTNQNMIKKTYPNNNEYIQNNYNNDFTNDTSLWQTTPNESFQSPQANPYFEQEIQQQIYPNQTNYRDSVVEKSKTENIPNNKQGGFTMNTEDFPVLGGVNSEQEQTSKKKKIIKNGKNSKNQKSSNSSPSENQINRTEEDDKYGLPGILQLIENVDPDLKALALGIDLSTLGLHLNYLEDFSTAFPSAWGDDLISYETPDCYQTEELGISLTPKLIEKFREKTLFYIFHYSDDENAKNLATQELQRRGWILNYKFTCWMKRKGEPPLRTETTETGSFIFFDSQRFAEIEQNDFKLEYEHTKPIQFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG38</accession>
    <name>A0A9Q0RG38_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_14754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000047">
        <property type="protein sequence ID" value="KAJ5078729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG38"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040271104" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="859"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="103495" checksum="3B9DBD66388B7A9C" modified="2023-09-13" version="1">MKLNLFFSFFFFLIINIFLIQSNQNKNQKSIQSSLISISPILTEIKTLTETTRYYSSFNEAWIWNLLDQFSGSLGDFGYSVSIYKDVLVIGAYSAKQAFIYRYNGTIWNQEQTLNESTSYFGYSVSVYEDVIVIGANGANQVFIYRYNGTFWNQEQNLYESASNFGESLSIYENVTVIGTYGADKAFIYRYNGTFWNQEQILNESASNFGISVSVYENVIVIGADGANKAFIYRYNGTFWNQEQNLSESATNFGESLSIYEDVIVIGAPNAKQAFIYRYNGSIWNEEQILSESATWFGYSVSIYENVTVIGTNSINEAFIYRYNGTFWNKEQNLSESASFFGYSVSIYENFTVVGAPAANEVFVYKANLIPQVNIINCSSLFSSFDCYWDKIEFPSTLKYQINYGYDWIDIDSPILEDENVYYQQFNSSIYDNITGNEYYSIQIHACNPTTMKCGESSSFINLTTKIDSVKDFQLSNPSNYSINVTWNYPNVQIDEGIAHLNHYNLSYFNQSQPDLISFISVDNSSLDYLWNNFECENDYNISIFGCRTQECEGDDKGEIVESSISLLFGEVTNLTCSILYSLDINCNWNQPINCSIPFYYNLTYQSIYQNDSGNYQPTSLNQQFTVQFPNQEYQINISACNSNGKCGYISSISIKTDNLTIAPIIYETISKIEEIEFNFTKLTNANNYSISLDNETNWQKFTSLDLNGNEVIGIISEISGNIEYNISIRGCVDLNCETPYLGEPSSIISTRAKLGNITSLNCYSLINGFICNWNSLILSSGLKSYSFKFNSISICLTNLINYYSISGLEGGEYYEISVYSSADLNCLNNEYSGINSTTSITILSPYQPTQSTDSNTTAISIGIFIPILIILIVIIAILLYQKKTKTKKQKQTKNLNQKQEEKELQDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG92</accession>
    <name>A0A9Q0RG92_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor i-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG92"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF366">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="576"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="736"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="977" mass="114631" checksum="81CCE451196049CC" modified="2023-09-13" version="1">MKKNSNQNQTNLNKTPSKTFKTPSPTSKSANKPNLYRSQNLPHPQNDPKSLIINHKNSPLNFGRSTSQKFNNSSEENLKKSPQKLPTKKMPTNQNEKFINLTEEKPPKPPPKKISPNQNEKIGNLNEEKPPKPPPKISPIQTKQNEKIGNLNVEKPPKPPPKKISPNQNEKIPNFDTLQRNNIFPRGKPPLQIKKQTTRPFFKMQNQESNEKPKFSINKSPIKFTNIPTKPILIEGKRKTPKESPKHSLEEKEKEKEKESKSKSKSKKSKKDKDKDKNKDKDKDKDKDKDKESKKKKPILTNETELLKSIKQSIVQRETIYIPQQNQEKTSQKISGNLEKIHEIQKNVIQEFEKTNQEEIHDSKNTNQEKQPKVNMINNPNIQEKNNEIQDEKILNKKSENPIWKESNESIEKEVEIPQTEWVAHIMKKNPDILNLRERIRPLTNEQSFGTLYEIGFTESKESLSRQKVIQLIMHHLYLKGLYKTIESLEFESQIPYELDYEKDSRLKRLVCLSLKSKNNLWDKNYITKYEDKTEDKEVLITENTFNFQEDEILNSDIPFWEELEDSEANIVYTEDGKFIKAANLNKLVEKLTHEETHDFKYMKTFLMTYQSFTTPRKLLAKLIQRYDVPKPSVITEDFEQKRYFIHLKVVNVIKTWIESHFSDFDENLIQEIGDFINEKLVKHNQVNLAIQLRNLMSKKISKKEKKNEILFPESPPEPKVPKNIFSRAFSLLDSDEEELSRQITLIQFKIYSQIESSELLNLSWNNSKLRHRSPNVLKMIYNFNQLSNWITSSIIFSGNQRSRSKLMIKFIRVAENLYLMNNYHGLISVISGMNDSSVTRLTSIWNEIPKKQMDFYLDLKNKMSSESSYRKYRDLLHNATPPCVPFLGVYLTDLTFIEEGNRDFTGNLINFTKRRLISSVILELQQYQQKPYNFQPIYQMSSLIEKLSFHSYKDCHQKSLEIQPEVTKTTSTNKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RG99</accession>
    <name>A0A9Q0RG99_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RG99"/>
    <dbReference type="OMA" id="NQEVNQM"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="559"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="738" mass="86729" checksum="22DDA4D1D31870B8" modified="2023-09-13" version="1">MIKRKRKNVSPHLEFEDLERVSNNMRKLLLLNGKDFSDVKIIVENNSKNFNCHWMILNLNSTYFAELFNSKFKKNSKNTKKTKPLISRSKVSKGFNSPFFIPNSKNISKNISKNISKKISKKIGIYDEKIRDLVQNEENLELNSIINLNKINQESKQLNQLNELNELNQEINQLKQELNQEVNKEVNQEVNQEVNQEVNQLNKESNQEVNQEVNQEINQEVNQEVNQEVNQEVNQMNQEVNQEVNHLNQEINQEVNQEVNQMNQEVNQEVNHLNQEMNQEVNQELNQELNQEMNQEVNQEMNQEVNQMNQKIEIQKEMEFFDIYSEIDEKEENIIRFPEIKAQIMANVLLFLYSGKIQFKTENVVEIMKVAHQLKIDKLTEFGEEFIVEHTKIPNVIDFFEIGVEFKSQYVKENCLHFIEKNISELIKNASFFKLKKETLDLILKQEKLEVYEELELFYAIIKWGQSQNGLPVQEIPKEKQDEKVINLVKDLIKYIRFIDIPSDDFFNLEALGIIPEQILFEVYRYHSIPNDQKMKIVEKNKNSKETFIFHSRQNNLKQILEESKILTKETVDILSDWLEEFKNFKLSFQATRNGFHAKFFHRFCDNKGKALVIYQTQDNYIFGGFTSLGFESGEDRNILDPLAFIFSLSNPFNTPPLKFSLRNHDQIAVRYYANNGPTFGSGHDICVNSSLKVGYTNFGESFLLPDQIARGSIQARSFLAGSYQGWKLKELEVFTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RGV9</accession>
    <name>A0A9Q0RGV9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000009">
        <property type="protein sequence ID" value="KAJ5080516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RGV9"/>
    <dbReference type="OrthoDB" id="17265at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="530" mass="63616" checksum="39C4D442CE23EE6A" modified="2023-09-13" version="1">MNSFSSNFFDPFQTFLSIRSIKILITPIDSIPTKQFEKYFSIIKSNSKIELKKNKKIYLDFLHSNYVNNNWQEFQPYKKIFGIIVIVNQTEKITFKTIKRLFHSKIEPYKHNLLTTKCFIFGSKQIENFHSKFIFIEYENDIESIQLKIKKHLELFVDEIVGNFSSQLLKLNKINRRISTPENIESLLTSSSKKKKMDQKFDMIKKKLLKVDYLLLGGELEIAHEEYKICLQLFPNDEYFPVYQAGCYERILFTFPEIYEEKHVNSDDFDLNQKTKKNQNLDFCPNYQNILSQFKFKQNIRNNSLIEKAKNLYQKTLAIYLENNNYILAIELIMKFCSLIISQKFDISLNRNLLVALKYSDNLDPNQKVYLLENVKNKNKNKNKKKERKKFFSSHLFLLFIGFAFLFYRINFKRKFLFFIYQAHSLSDSNDSLFILREFLSQYLIKRNNCQNNKNNKNKENNKNIKNNENNQNNENNENNENNENIQNNENNENNQNNENNQNIQNLKEIQFRRIIKIIKIMKNNYKQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RH23</accession>
    <name>A0A9Q0RH23_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RH23"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040168124" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="363"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="464"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="564"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1084" mass="119361" checksum="D917DB2BDB1CA254" modified="2023-09-13" version="1">MAINSKQSKSTHNFNLKCVVILLFFGLVHTQKVSASKGLKSDNLWTLSQIINSPNSSQTFGYSVSISPSMSVIGDPSSQFAYIYQLQNGSWTSFQSFTHWSHFGWSSAISQDSSMLGVGNGPESGFSLFFFNGSQYERTDYGSWKLEDDLGPGLGWNLVLSNTLRLYVFGAPAFTAVGSIYENKLAGSYGGGMDEGLGNSVAISENPAIIIASCYFVNKVYILSATTSSIDYISHIESDLDGFGNDLAISSGGNVFVVAAMLSNTTVIYRKTGNNWVEEKVLIGDLSNFGSSVAISEDGNTLFVGANFTNKVYIYWYSGSDWEEKLVLSGPASFGTSISLLGDTSFISAPQEGKVMFYTNPTPDSKPEVTFVNCSPEYSGFQCNWTQPENNISLHFLINYGNGWFEVQDPMFDTVSNQFYQLFTSSNYSGLYGNQEYSVQIRACNFTSEGCGYPSYLVQVVARIGGVEDFKLTGGLGCIEVSWLPPNVKLIDDLPDLDHYVLGHKCEWMEDTVYQNLSNSESSYQINNLESGYSCEISMWACSTPECTDDARGEIIVGEVDVLMGPVNDFQCSSLVPLVINCSWFPPDILHTSPYYKIYYQSDSYGDENTLQTTELNISFSVSIPDELYHISISACETNQSGCGNSSLANLDSLNIPGPNIIEAIPEIEAIEIIFTPVPKAKSYILLIDEMEWLPFSSLISNGTEMIGTLENLSGNIPYYIYLFGCTQVICQSQYLGEMSQEIVVQPKLGNVTSFNCNPIVCGFECAWDELVLSDGLEAYLFTYNSESRCLDKSAANISISDLFSGKDYEISITASDSLNCQSNGYSGLSSTTSIKTDYIPSPSIIQLNSKIEEIEIIFSKITQAKSYLISVDGRISWLNFTTLNSNEDEMIGTVNKLPGNVDYYVSIRGCSDLNCTIEYAGIPNTPILIKSKLGNITSFFCNGTLSGFHCEWELMELSSGLRGYGLTYDSQTICISKLMNEISIFNLIPGVNYEISIFASSDWRCETNEYTGLPSTVSITTLSPTTEETSESSTDLKVVVPSIIVPIVGIAIIIIIIIWIRNRSKKNQKENNQEKEMELSNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RHH4</accession>
    <name>A0A9Q0RHH4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000012">
        <property type="protein sequence ID" value="KAJ5080169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RHH4"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="214"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="330"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="500"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="602" mass="69756" checksum="5E856C4C33DF5330" modified="2023-09-13" version="1">MNSEKEINLKEKEKEKNDCLFFGKNTSPKLLENESNSLTIPVQFRFEEQFEKQNEKQIKQISSSLFSTIFLFENGKAIEYLKNSKQNPERIEMKNIRKVTVGVQNEAILTIDGDVFAKGKDINSKKPNQFINISKFIRNIKDRTIKDIVSERSSIYLLTSNQNVYGIGSNDNGQLGSDYRKLQKTEKPILMMKNVSKIFAGNSSRHVFLLNSNQELFGCGFNHDGQLGLGESTKGSKISKLTKIQNIPKGKIIDIQCGYHHSIMLIENEDENKNPKRKLYSCGFHQFNGLGKNENTKKFTEIKSSLFENDDNILQISCGFTHTLILTSNSQVIGFGNNEFGQLGKTIKNEEILSQSIPIQIELPELAFDEGVSNYHVSCGYNKSFLYYSPFASFSNFEGDLVKLFRRKEFCDISFKTENGKIIEAHKLILKYRLNENEFEKLQEIISKKSIKESNQIFEMIYSNNPRINSKLYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILAMRSELYRIMFLTVIDDKSNKVTDYSGLSNKAFEILEYWIYSNQIKDEIQITQEIINEIKIGIDYFQLNETNPNLLDLLNNKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RI50</accession>
    <name>A0A9Q0RI50_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor dp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_14083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000010">
        <property type="protein sequence ID" value="KAJ5080488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RI50"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.80">
        <property type="entry name" value="Transcription factor DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038168">
        <property type="entry name" value="TF_DP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014889">
        <property type="entry name" value="Transc_factor_DP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08781">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01138">
        <property type="entry name" value="DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor DP C-terminal" evidence="5">
        <location>
            <begin position="141"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5080488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="269" mass="32035" checksum="45993AF2B894EF96" modified="2023-09-13" version="1">MEDDFISIIKESGLTEIAEDCDVLTNGNLNLQTNIDLEKSFKKIKKENYIEEITENKPINFQDIKSICFSICSIISENKLINLKQLFELVSKKNEQNKLENEKKQEIHFYVALEILKQVKIIEMNENETFNFRGFPEFRQNTYHFSKGEEQFHRSNIAKKLEYLKDLVLEKITYQKYYEKMEEKKISKNESVKFPFIVINSDKNSRVQMRTNPEKTASLFTFSERFEIHSDVEILEKMGFYQDISQIEDKELKRTIPENLIPLIRIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RJF5</accession>
    <name>A0A9Q0RJF5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000001">
        <property type="protein sequence ID" value="KAJ5080789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0RJF5"/>
    <dbReference type="OMA" id="WEKIMLK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="377" mass="47392" checksum="6927CF0FEEAE70AE" modified="2023-09-13" version="1">MELFTEKNKKVQEEIKELESKKNFKSEEEKQKTENYKINLMKNLKMIEMQTAEFQMRRQAIKEEIRAIQEREHEIENAIMEQEDQIRKELVEMAEKEEDIMEEKNMKEKKQEEYERRRKQEEDERRRRQEAIRKQQDEDQSYRQRKYLEDIEYQRQKKEEEMRLRQMEMAMIQEEMKAMQLMLNKELAELTNVEEELEKEFVELSKHKNELKKKLEKSLLQDTSKSKEEKQKIEDEKMQLTKQIKAMEMQTQDMQMQREQIQQEIDSLKEREHALKHEMEEVIMQKEENMRKELVEMAEKEEEVVKEIRRREEEIKMRQVKEEEEYERRMKEEYERRKKEEYEKQKRRKKEEQENERRRNKKMKEECKNKQFSEIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5C8</accession>
    <name>A0A9Q0L5C8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_13609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000143">
        <property type="protein sequence ID" value="KAJ5066411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5C8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="153" mass="18369" checksum="AEA926C90A02DEB2" modified="2023-09-13" version="1">MEQNNEKLIKVDQTLIEFAKENKIPVELENIKSIKKLKIQHLRFIHNDISQHFESIINKIDNQYKNQIPTTFLNQLDSFLKNFNYKFDINFPKFLFKRINSKIILQNKNFLNNLVNIGDLLNLKTESETIRKHFPRHLTLKVYLLCLDKLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L5P7</accession>
    <name>A0A9Q0L5P7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Liver stage antigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_03598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L5P7"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1920">
        <property type="entry name" value="UBAP1 SOUBA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038870">
        <property type="entry name" value="UBAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042575">
        <property type="entry name" value="UBAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960:SF5">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="395"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="441" mass="53507" checksum="25F3EFBC1F993488" modified="2023-09-13" version="1">MNLFEFSWIKIDPKFLPQNTTQIVLPRIDGELPNYDFKLEKETIEAINKLMAQTEYEKMEREEREKRIKREMEEEKMVLEMLEREENQKLKQKEEKESMFKSEQLRKAEIELQKQEEEKIRKEEIQKMKEEEKLILDKILNEERLERERIEKERFEKERIERERIERERIEKERIERERLEKERLAREKLENERLEQERLEKERQNQEQPQQNAYSNPNLYSNPNLYSNPNLYSNPNLHSSPNLYSNPNLKLYENPNPNLNPNPNPNPNPNPNPNPNSYSNLYSNLYQNSKSYPNFYQYQYQYQNPNPNPNQNPNQNPNPNLYQNPNPNPNPNLYSNYYQNQNANKETQLYKPTYQNPNPIKQEKFPKEFQNTLSYFVNLGYSRNITIDALNYFQNDKQKVERFLKAFDQIKDFGFDENSVKQALIQNDCDPEKAIQTILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L627</accession>
    <name>A0A9Q0L627_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_13588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000142">
        <property type="protein sequence ID" value="KAJ5066475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L627"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040437490" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5066475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="12677" checksum="07ADB34B4008B01F" modified="2023-09-13" version="1">MNIKVLFLLVLLGIVASQSMDSTVSALALFYSDEYCTQQIGSAELPAGSCVILSGAQSTGAAMKTNVTTTINYYSDTTDCTGNSIVLDSTANVCYYNGSGSGFIAVQIGVIALLLISFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L6J6</accession>
    <name>A0A9Q0L6J6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_03292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000136">
        <property type="protein sequence ID" value="KAJ5066948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L6J6"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5066948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="143" mass="17362" checksum="5398DAB44C8BD1CE" modified="2023-09-13" version="1">MTLLKYTDPKNTSLKISILKILPHFIESYNFIWNKKEYEDIIDCIRFLNFWMNKDIVFQSEELFHFLVINSPEFQAKSFSFLPLPSEVDNFLERSFNRFHQEDDKDEYSKEYRMLFFKKEEIQPKEDESLQIALTKLLNSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L761</accession>
    <name>A0A9Q0L761_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 35 member b1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_02800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L761"/>
    <dbReference type="OMA" id="CGAIGQV"/>
    <dbReference type="OrthoDB" id="78344at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5067612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="306" mass="35665" checksum="41455BBF64A9E81C" modified="2023-09-13" version="1">MFKSTSFWKFISSSLGIYFFFMAFGMFHEELLSTKYSEKEFNLILFLNFVFDFVNSIIGFFGDWIISRKIKRIKAPRYIPPYKILVLSIMSLTTDFLGQKGSLLTNYPTQVLMKASKPLTILFVGQLIFKRKYSIRNSKFHSTTQSIDSKYFLGLIFLVVDLIIDGFFGSYQDKLKKQYEKPSLFYQMKWINGWKGLILGIFLLLNKNIFQGINFCLTNRHLGFLIIACALSMAFGQVFIFFAVNNFDALTVSIITTTRKFFTIVLSFFVFKHSFNSNQFLGIFLVFGFLLFDLIMSSFETKQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L844</accession>
    <name>A0A9Q0L844_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_03021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L844"/>
    <dbReference type="OMA" id="NQMNVQD"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="203"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="438"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5067831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="518" mass="62177" checksum="AA8F8A6A8901E9AA" modified="2023-09-13" version="1">MSNNKEKSKEKSKEKSKEKSKEKSKEKSKEKSKEKSKEKSKEKSKEKSKEKSKEKSKEKSHHKSNQKSNQNQMNVQDQIIQMQNQIQLLLQNQNQMNVQDQIIQMQNQNQNQNQNQNQNQNQNQNINQNQIQNQNQNQNQNQNINQNQNQNQKITFKEIYSKEKSQKIQISKLYQFPSQELNKFLICELLSNYKIMFENEENCDFTIYAGKNNQKIPCHKSILNSRSRFFYENNHEKTENEELYLPQFEYDIVKSIISFIYYSEFKFDLNKFEKYFQLSKYFKLTSLIIKIEKEVSEQINEKNVIPIYFKSISIESNYLSNICENFIKENINKIIEEKQIGSINNKELKEIIQIIQSTSKENKIDLIWKLSQDWKNKFKKSNKNLINKEKYIDPIQIQEINNEIQNFYLIIDTIKNDGFISNDSRNENNLILPSTDQLQLINQKNQKLKKTIKKQNKIIQQKDKEINQFKQSIQQKDKEINQLKQAIQQKDQEINQFKQTIQQKDQEINQLKQKNKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L8F5</accession>
    <name>A0A9Q0L8F5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_12428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000117">
        <property type="protein sequence ID" value="KAJ5068316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L8F5"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="295"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5068316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="395" mass="45465" checksum="9F506E7E85D1BF98" modified="2023-09-13" version="1">MSSSESDDLSELQNACEKKKSFDFIKNLIKNGVDINKKDNNTALHNECFDKPRIEVIKLLINSGANPNIQNGLIPLHYVCRNKNTLEIVKFLIESGSEVDTLDDFTPLFNAFDKYEIAEYLLSKGAKTETSESVLYLMLINNAPLKNIELVLDYGADKTFILKEKKLEQLTKSKRIQTLIKCYDSLCEDMKLLLKEGGLYDINIKTQGKEIQAHSLILKLRLENQFEKFLENIQKEPFEIAETILEFIYTGYPFRNQIVIDFFNDLFGDSFFPKKVGKKNLIKDLTNLFNDSESKDFEIIIESNKSNSVIKVHKLILFARSELFKGMFLSVNDPSNSVVEQSKKSFQTMESLISFFYTDSIDISKLSKSSKKELFDSINYFGLNLNSFLQFFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0L9V3</accession>
    <name>A0A9Q0L9V3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0L9V3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="331" mass="40475" checksum="5FEC6D38BAED7DF5" modified="2023-09-13" version="1">MDNNNNNQIQNANQNQNENEMKNLEKKVTKNLIKNYSNLLNENSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSISLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLDNWIKKRNKKLRLRKYEHKMNSKKRLFHSFFSLFDKDSISKQDFDKLKQFDIFLPNSFLIDFERTIFQIQDQENQTKIKENEKKIKEKEKKIQENDKQIKENEKKIKRRDKRITRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAP3</accession>
    <name>A0A9Q0LAP3_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAP3"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="190"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="253"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="474"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5068460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="589" mass="68322" checksum="22CF8E6D9F7E5322" modified="2023-09-13" version="1">MNEIIFFGSNKKQILLKSEPNEIAKPIQFKFEIENEKQIKQISSGGLSTIFLFKNGKAIEYSNQNPSKIQIENIQKVTIGYQNVAILTKEGNVFAKGYEINPKNPNEFINISSLIEDPNDRIIQDIVSGAYSIYLLTSNQNAYGIGSNYSYQLGFQIAKKEEKPILMMKNISKIFSGNTSNYVFLLNSNQELFGCGYNHYGQLGLGESRKEAEINKLTKIQNIPKGKIIDIQCGTNNSVMLIEEDDQNENPKRKLYSCGHSEYNGLGKDEYEHTCEFTEIKSSLFENDDNILEISVGDSHTLILTFNSKLIGFGLNNSSQLGTGDTKNQLIPIQIELSKLRFNENISNYHLHCGYSNSFIYYSPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNENEIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKYFIIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDGIEITQEIIDELETGIDYFQLNQTNPNLFDLLIKKFNNQNQNQNQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAR5</accession>
    <name>A0A9Q0LAR5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Presenilin</fullName>
            <ecNumber evidence="11">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_03040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer, nicastrin, aph1 and pen2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="11"/>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAR5"/>
    <dbReference type="OMA" id="MYYQDID"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044351">
        <property type="term" value="P:macropinocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000003">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="300"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="346"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5067850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="494" mass="56547" checksum="7DFB13C2920BA93C" modified="2023-09-13" version="1">MDSLSSQEELKESDIEKPKKETENLNENEIENEIEKENSQEKPEKETEEQKKKKYWDRSKIRRMRQLMKEKRFEVMIQAFTSSLKRILIPVSITMILTVILIKTLYSDQTMNNQFQDVSVYNENSSDSGGKKFAGSLLNALIIVGAIVVMTFLIVLCFKFGCMNLVFAYIIFSTFIMLGIIGAVTFIELLVAENLGMDWLSFVIFMLNFAVVGVTVIFWKGPEIFNKMYLIAVSVLVAKVFASLPEWTAWILLGAIAIWDIFAVLSARGPLKVLIETAQQEDKPIAGLLYNSSLYFENDYDNDDNDNDDENSDKNHESSSDKDHKFVDNPYSTSSDEDNFENDTNQPKKNEEIENKTEDNNETKKEDQDDDLIKIPKEVFPERKKRPETKKPEKVQYQYQYEDEDEGGIKLGLGDFIFYSVLIAKASLNDYSTVFTCFIAILTGLSLTLFFLIVYQKALPALPISISFGIIFYFLTKLVLDPFIEQLGNSSVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LAV8</accession>
    <name>A0A9Q0LAV8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000109">
        <property type="protein sequence ID" value="KAJ5069085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LAV8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="66"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="171" mass="20688" checksum="4C5349C93E75D8D6" modified="2023-09-13" version="1">MKLKNFKEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIEITQEIINEIETGIDYFQLNQTNPNLFDLLTKKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBB2</accession>
    <name>A0A9Q0LBB2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBB2"/>
    <dbReference type="OMA" id="ANALWME"/>
    <dbReference type="OrthoDB" id="15749at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="413" mass="47484" checksum="D996B448877B9F08" modified="2023-09-13" version="1">MARSKPNIFWIIGAQIVSVVGDAFGQRCSRVDHKSSRKHMMISFPIISSLQIFLILLILEYSLPQSIVGAIYRDSNKIQCYKEIDIEGKDIHCTDQTCTKIKCPRGGPIEMFRSLKHYPMLFLNGVQNWFYYSAEVILYREPLGLLFLVLASLASSFLIEPVNKIFGSPASTQNIPGYLIFLGIFGSIICIVEKKISNKKKNSNQLKEDESKFLLENEFDDEKNSNSEKESILKKLFLPFAILSFTYSVWFVSQTYFNNNCRINAFTYTSVDQVLLPFYLYPFMFLMDYVSPFKKCFYDGSDKIETLIGALLPTWKESSIFNLFVYRLLINGRAFIYYYLAILYDINLVYLQLTLIRIVFSWVGSLILCLLVPKFIATTKAEKDQTFSLFNIILKITGSIIVVVSLILLNEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBF9</accession>
    <name>A0A9Q0LBF9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBF9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="616" mass="71410" checksum="137B91AD3625070C" modified="2023-09-13" version="1">MNEVLFLGENEYPKLFKNDPNEITNAIQFKFENENENENEKQIKQISSGSFSTIFLFENGKAIEYLNREDPNQNPHKIQIENIQKVTVGWQNEAILTIEGNVFAKGKDINPNNPKEFINISSLIEDTNDRTVQDIVSGYNSIYLLTSNQNAYGIGSNRSDQLGVDSKILKETEKPILMMKNVSKVFSGNTSNRVFLLNSNQELFGSGYNQWGQLGLGKSRKEAKIQELTQIQNIPKGKIIDIKGGNIHSIMLIEEEDENENPKRKLYSCGSAISNGLGKKFGEDTYEFTELKSPLFRDDNIIEIDIGFLHTLILTYKRKLIGFGGSMSGQLGNGKTSPNVFKPIEIELPELSFDRFNYHICIGANKSFLYYSPSLSFSNLEEDLRKLFQRKEFCDISFKTKNGEIIEAHKLILKYRLNQNQNQIEKLKEIISKKSIKESNQIFEMIYSNKITNPILYSEIKEIINSNEKIEETMKRIYLNENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDTSNKVTDYSELSNKSFEIFEYWIYSNQIKEDIQITQEIINEIKIGIDYFQLNQTYPNLFDLLIMEFNNQKNKAFEEQLKSSPELSILFDLLMKLAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBS7</accession>
    <name>A0A9Q0LBS7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000103">
        <property type="protein sequence ID" value="KAJ5069550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBS7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="17707" checksum="43E2364E12AFDB33" modified="2023-09-13" version="1">MIIKIMKNDDENDDENDDDENDDENDDDENDDEKMMKMMMMKIIMKNDDENDDENDDENDKENDKMKMMMMKMMMKNDDDEENDDENDKDKDKDKDKDKDKDKDKDKDKDKDKDKDKDTNNEDEEIDNYSNLIIYLEKYMKFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LBZ7</accession>
    <name>A0A9Q0LBZ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_11415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LBZ7"/>
    <dbReference type="OrthoDB" id="1911769at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052457">
        <property type="entry name" value="Ankyrin-DD_containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24125">
        <property type="entry name" value="ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24125:SF5">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5069903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="181" mass="21279" checksum="E12D6656778C0E39" modified="2023-09-13" version="1">MPKTNQNQTALHLICKFNSILIIKYLVSKGIDINAKTNENETALSISIKKQNENVIKFLLMNDVNIDNLKQKHITKQFIELFSQIYSLNEDMNNLLKSNDNFSDLIIQSNDSFKFKVHKLILLSRFDNNELILQKFINNCYQKPKEEVEIILNFLYTGFSNFDKIIQLKNENENEMKNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC32</accession>
    <name>A0A9Q0LC32_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000112">
        <property type="protein sequence ID" value="KAJ5068843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC32"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5068843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="130" mass="15612" checksum="A54E1D42B8C74B85" modified="2023-09-13" version="1">MRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKNEIQITQEMIDELQIGIDYFQLNQTNPNLFDLLINKFNNQNSNTNQEKKRTREFINQLNQTNQNLLNLLINKFNNQNQNQNQNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LC79</accession>
    <name>A0A9Q0LC79_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/arginine repetitive matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_11242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000099">
        <property type="protein sequence ID" value="KAJ5070038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LC79"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="211" mass="25668" checksum="852851474B1F7D23" modified="2023-09-13" version="1">MKKIKLESVIPWITQKIYDLVIEDEVLAEFAIALLEETRFPDPKQMQVQLTGFMDRDTGQFMKELWRMLLDAQNSVGGIPSSLLNQTKLEIKQQKDEHDRIQQELQKKREKIEINEREQLKELIEKEKDKEKEKEKEKEKEIQTKNISNLIKNENIKEKIENHKNKHHSRNHHNYHNYHNYHSRKHERKHERKHKNSSPFDNQLHQSRRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LCE6</accession>
    <name>A0A9Q0LCE6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Low-affinity phosphate transporter pho91</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_02648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000114">
        <property type="protein sequence ID" value="KAJ5068705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LCE6"/>
    <dbReference type="OMA" id="HAKGRRN"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="123"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5068705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="550" mass="60999" checksum="A53526ECA3C6A8FF" modified="2023-09-13" version="1">MSTTDNNETKLNSETTFEDPFLIADTENMDTDFKDSTERSYESSTESYEQYEDQPLIRRANEQSTKCCKFYDKLNRAFQKIEVKMIPFFISIIIFLVVLLIPVLKDHPEAHRCLAILLFAASLWATETFPLFVTALLVPIPVVWFKVLLDDDNKPMSAGEASSQITYRFFDPVVLLFLGGFCIAQALHKYNLSERLANIILRKAGTKPKKILFLTMLLGLILSMWISNVASTVVCISVLLPLIRNNIPDGDPFQKALLLGIAYSNNVGGMTTPIASPQNAIAVKVSNQISDNNEPIGFFQWIVIAFPTAFLVMLFTYLFLLKFYRTRLKAVEQVIYTPQRLTYKHWIVIVTTIVTVLLWCLNSLIDDFVGDLGITAIIPVIVFFGTGILSKKDLGKLSWPVLLLMGGGLALGYAVQQSGLLHLIANGISDIVGDSILLWVISAFAVLMIFASTLISSTVAAVIVLPIVGAIGDSHHHLRLMLVLVDLMTSGGNCLPISSFPNATTFAVSNDKGNQYVKTKDYLVVGFFVTVLTYLGMISSSYGIATLFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDU7</accession>
    <name>A0A9Q0LDU7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Saposin-like protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_01857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDU7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5070876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="23295" checksum="AE9C26D062DCEFA5" modified="2023-09-13" version="1">MASIYSELTESESLLVFIESGYLGIDICREFSFCSGKIKKKTDPAKCVACEMLEAEYTEYSKTQNISWSSNSQEIINDLPQQFQNELKQLIIEYPKIFEEMDYDFCSKSEICTLDLIFDAKPQSNPLINLDFIVCDAIINELIVFLNKNDKENIIQFLSSLCNYFPAQFQGSCTEIISQQKEAIVLVSLSYPNFLEKLCELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LDZ4</accession>
    <name>A0A9Q0LDZ4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_10709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000093">
        <property type="protein sequence ID" value="KAJ5070639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LDZ4"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="418"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5070639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="590" mass="68781" checksum="1E057BFB3285703F" modified="2023-09-13" version="1">MNEILFFGLNEYPILIKNKPNKITKPIQFKFENEYENENEKQIKQISTSFFGTIFLFENGKAIEYLDGNDSNQNPVKIQIENIEKVTVDSENEAILTIEGEVFIKGRTIHLGNPKESINISLLIEDTNDRIIQDIVSGVNSIYLLTSNQNCYGIGSNSDCQLGFDSETLKITEKPILMMKNVSKIFSGNSSHHIFLLNSNQELFVSGWNQYGQVGLGESRRETKIQKLTKIKNIPKGKIIDIQCGYSYSIMLIENENENENPKRKLYSCGYWQRNGIGKEKENTYEFTEIKSSLFENDCILEFSCGNAHTLILTSKGKLIGFGYNSYGQLGIGNTNDQLIPIQIELPKLRFNENISNYHLSCGVSRSFLYYSPFPSSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNENENEIEKLKEIISKKSIKESNQIFEMIYSNRIINRKLYSEIKEIINLNEKIEETMKRIYLNENEKDFTIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIINEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEB7</accession>
    <name>A0A9Q0LEB7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000089">
        <property type="protein sequence ID" value="KAJ5071312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEB7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="151" mass="18115" checksum="74CDE45448B2A161" modified="2023-09-13" version="1">MDFIETHSVKKIEATEKENLNKEKIEEKMNLSPKKESFDCKKPTIQKPKKQENFLLKRKIIRSILKRKLTLTQIPPKIGFEKDSSIEITQNKFGYEENTEPNGEDNQELFPLIKRPMNNFLSFPITKNINGKRLFWIMEFFKYKLIKFMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEC1</accession>
    <name>A0A9Q0LEC1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-deoxyglucose-6-phosphate phosphatase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_10085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEC1"/>
    <dbReference type="OMA" id="IWCPHPG"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5071676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="225" mass="25010" checksum="C3A704C4AF7661DE" modified="2023-09-13" version="1">MENKKEIKGCIFDLDGLLLDTELIYAEALQEFLDVVSPGKKYTLDLKLKIMGASPEVGALVLIKELELPFTTEEFLTKRKPILHSKFPECKAMPGAEKLIEHLHKNKIPIAIATSSAKETFGLKTKKHKFIELVDEIITSDKIKNSKPDPEIFLLAAKNLNLSPAECLVFEDSLNGVAAGINGGFPVIHVPDPELDLSLRQKLPAQTLSSLLDFDPTFWNLPSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEL8</accession>
    <name>A0A9Q0LEL8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab7b member ras oncogene family-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_02017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5071035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEL8"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5071035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="309" mass="34427" checksum="FE9051B090E7B143" modified="2023-09-13" version="1">MASSVLVAQAVTIIYGVVVGIYALIVYLARKTAGMKTLLFGVSSFLYFLLSFIVSLFDSSQKAGLVMSVIGLSCFIILFTVLIIKLRSWRDIICGSLTLICWIIVIVVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVLVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVNVLKTFENLDSWRDEFLIQASPPDPDKFPFVVIGNKIDLDSRTVSPKRAEAWCQSKGGLEYFETSAKEATNVEQAFQTIARNALKREQEPDMIFPNEDTFKIPENEEIDAPPKKSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LEP1</accession>
    <name>A0A9Q0LEP1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_09770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000084">
        <property type="protein sequence ID" value="KAJ5071871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LEP1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="145" mass="17575" checksum="8CFE7A66D88733CC" modified="2023-09-13" version="1">MIYSNRIINPKLYYEIKEIINSNEQIEETMKRIYLNENENDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITKGIIDEIKKGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LFE5</accession>
    <name>A0A9Q0LFE5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_10110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000086">
        <property type="protein sequence ID" value="KAJ5071701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LFE5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5071701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="140" mass="16765" checksum="511C236A84D26194" modified="2023-09-13" version="1">MNTNQDQIQEEIRKIQEQNTEIQEKIQDLIERHKKDKNKNDLNPNPNPNQNQNPNQNPNQNQNPNQNPNQNPNHQNRKINQISKKFYKIHFKIFSLNCLKFTLKAIIIRKLIGSDQNTFWKCLEISQPFSDILILLYIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LGB0</accession>
    <name>A0A9Q0LGB0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LGB0"/>
    <dbReference type="OMA" id="NQRRCII"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="190" mass="21105" checksum="A83B9E31E252F868" modified="2023-09-13" version="1">MNRFKIVVVGPGAVGKSALTIQYVNGEFVSEYDPTLEDSYRKQAEVDNQVCLLDILDTAGQEDLVSMKDQNLRSGQGFLIVFSVTSKHSFSQVAGIRDEILRAKDSEDVPIILIANKVDLVNDRVVTETEIRALADDLAVPFLETSAKTKVNVDEAFAEIVRILRKKGKISNPTVPSNSSKKKKWRCFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHF2</accession>
    <name>A0A9Q0LHF2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">M0811_09274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHF2"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="63"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAJ5072828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="547" mass="61590" checksum="AF8F2855AF7111FA" modified="2023-09-13" version="1">MSHIGRFNIPTPHNQSLLSYLPNSKEAKKLKEECEKMRKEIPFEVPCIINGKEYKTGNIKEQLIPSDHKNVICKFHQVSEELVQEAVKGALEAKKKWEEMSFESRAAIFLKAADLVVGKYRYVMMAATMLGQGKNIWQAEIDCMAELADFLRFNLKYIEEIYSNQPKINSTAVWNRLEYRPLEGFVLAITPFNFTAIGGNLPTAPAMLGNVVLWKPSSTAIYSNYIFYKILQEAGLPAGVIQFVPGTGSMIGKILLKNKDLAGVHFTGSTAVFKHIWLESAKNTMSLYKSYPRIVGETGGKNFHFVHESALIDNLVNHTIRGAFEYQGQKCSATSRMYIPKTIWPEVKEKLIKEVSKIKMGQSDDPTSFMSAVIDKNSFENIKKYINEAEKDESVELICGGKYDDSVGWFIEPTIYLTTNPKNKLMQEEIFGPILTIYIYEADKYEETLELCDQTSPYALTGAIFANDREAIDIAIKKLRQSAGNFYINEKSTGSIVGQQPFGGARGSGNNQKAGAITNLMNWCSPRSIKEGFVELKDWKNGHEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHG0</accession>
    <name>A0A9Q0LHG0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_01499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHG0"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5072484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="186" mass="21090" checksum="6690EF41FE0739F2" modified="2023-09-13" version="1">MQNSSDFSDSEIVKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSKNWHKAVDGKGKTLVIIKTKDNFIFGGFTQVGFNGNTGYIKDSNAFIFSLRNDKGDRIPANFTHNGKNRAIYSGLNHGPWFGSGSDFILESNLQPGYSDFGKSYNLPNGITYDTNETKSYLAGSYDKWVVDEVETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHH2</accession>
    <name>A0A9Q0LHH2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein rrp5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">M0811_09304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000079">
        <property type="protein sequence ID" value="KAJ5072858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GQYLRAY"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000065">
        <property type="entry name" value="Programmed cell death 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057300">
        <property type="entry name" value="OB_Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24682">
        <property type="entry name" value="OB_RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="161"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="254"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="463"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="552"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="649"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="748"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="860"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="1171"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="1285"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="1519"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1246"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1327"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1600"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1679"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1328"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1602"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1631"/>
            <end position="1654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAJ5072858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1988" mass="232045" checksum="D57F36DFFAF2FA27" modified="2023-09-13" version="1">MKEPKYIENLTIYTLTKGMIFLGVIQEINEYEMKISLPNNLTGIVHATDISKEYTQYLKKTLNQIEEIKNENENENEYENENEYENENENENQLQNNLNQNESNQKSLLESELNSLFKIGQQIPCFIKEMDNERNKKQITLSLDPSFINESTLSIKDIFTNQVLYGSVKSVEDYGYTISFGENCSFFGFLHQQDIIFNGIYKNDTKLYVGQDIYVIAQEINQESNTIKLSFNYRKAMNTQLNPKDYIFHNLKPGDLINGNISNVLNQGIVVNFLTFFLGVVDRKNFPESNPRNEDDYEFKMNQKVKCKIIWIDRVQKKIRMTMKPNIIQGKHVVQKDIEVGDIYTEAVIKRIDEKIGILFEINLDSKIKYKELREYLKQKKEEKEDENVKIEDKEKTRKIFGYSVYKDCSDENKPSLSEVFEVGQNLICRVTGYNFMESIALVGIKRSIIRRKFMGIKEIKVGKKIKVEIEKIEPSGIIVKITDNIRGLIPKIHLADVAVKIPELKFKIGRKVDCRVWSTEPARNRVILTCKQTVIESKYPKIVELEKVENGMKSHGVIVAIKDFGCIVKFYNNITGLLPAAEISNNPIEENPRKLFQIGQPLLCTVLNAEPKKGILRLTLRTNILYFTHEEYVQNQNVLSQFDKFKCGELVDGVVFTLNNQGCVLNILAKDQKTELRGFLAKNHLCDDPKQALKMTEKIKIGTHLQSLMIIEKDEVKKTFLFTRKYVLLEALKKKQLPMNLEQIKTNDIVYGFVKKITKFGVFIGFLNGLTGLAFKNEIADKFVKETSDQVLLGQTIRAKVIEINEEEKIYLTIKESECYSSDALFLLSHFHYQMETETMDKESSINQFDEKYQKLQIGNKIKIQIAKVEEYGAIARLENFEELTGFIHKDQCNIKEMKEGNSHRAKIIDFDFSKKIIDLSLKSDLLKTKTKTKKNLVFQNLEKFDSKIELVKKDYLIVSIPQKQNQIAFVSFNDFNSVNDKQIKEPFERFKSGQIIKTIFPEETNSKAKQLKIQPQRMILAMDEDEMVPDKSQLIRNKRKKQENQFKRIEEIKTGEIVKGKITNIYDCQMNIRITAEIRGRIHITQVFDTFPGKKARAFDQFNEGDEIEARVLGIYEHQTQEPNLVKKYLELSIKPSLLSSSKKTKSILDEFSKLGLDQKFGFHSFEKDQIAVGFIQEIQEDCVFVALSPIARGKVKSSEISDDPKILRKLSKYFFCGQAVKVKIGFVDVENKRLVLSMKRAKYEENENENENENENENENENENENENENENENENEYFKVGSVVSAIVDKIIPSKGVRFKLENDQIGFVFLTELNDQLVSYPLGEEDDEDEDDLQNSKRKNKKKKAKQKRINIEEGQSFQCYVLGKKGHIIELSLRKSKINLIDPTIMENDLEIQEPKNINKSQYDIKIEKIDHRRKKDVRKIKDFKIGDIVAGYVYRTTNNQVLIRISGNAKGFAQTGYLSDDFITKISAVFRPGKLVYGKVIEIQESNNKVKLDLRLSSLGFKILSIDDFNKGQICEATVFVISEKGMIVNIKDSQMKGFISMNVFLKDENYKGMNAKKVKKILEQEYKKKDKVLIEVLNIDKENKRIFSKVIEKEENEENDENEENDENEENDIMEYKELKEIDESDESDESDESYILDDESDDDSDQNEKQSNQMDIDVGFEWDDVMFEEKENRNQKSNKKKDEKTEKQKNRKKKEQEIYEKEKEMIESKKPPETGEEYERLVVSSPNNSYIWIKYIAFCISMDNIEKARQICERALKTINFREENERMNIWVAYLNLESQYGEQEKMMKLFEKALQFNNQKKIYFHFVGILENNEKIELCDEIYQRFCKKFGQSAKVWKSYGIFQIKHFGIEKGRQVLQNALKSAPKRKHIMIISKFGQYEFKFGSAERGRTIFEGILTNYPKRVDLWSVYLDMEIKKGDQQMIRNLFERVITLNVSSKKIKFFFKRYLQYEKEEGNDERVEYVKQKAIEYVQSLISQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LHH6</accession>
    <name>A0A9Q0LHH6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription elongation factor spt5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000078">
        <property type="protein sequence ID" value="KAJ5072922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LHH6"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057934">
        <property type="entry name" value="KOW_Spt5_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23287">
        <property type="entry name" value="KOW7_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="2">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="374" mass="39911" checksum="E1C01381C2C5C3C1" modified="2023-09-13" version="1">MRGVSDEFLGATVKIKLGNYKGYIGFVVSVTENEASVQLSANSRVIRVPKTSLMISGKQPTRSRSGISTENSPGITTPWLEGRTPGYGGQTPGYGGQTPGYGGQTPGYGGQTPGYGGQTPGYGGRTPGYGDRTPGYEPDRTPLVTNEIWNPRPHQLGTGTPTNFSQTPNIPLTSSTTSIETPTVTTPMSYPHALVSPSIGTPMSFPTTSTPGLFAQTPNTPTMTTTPLIQTPTQTVKTPTTGQYSFFSLPEDQQLNPKTPIIGQSAIPKWCFLGASVVVQGANVEDQEGVVESVQTNEHTAVVYLPKDGSRSTISVDNLTRENPEKNDYVKIFDGEHEGEGGELAGIDGNYGIVKMSDDMRIIDLNLLVRCKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LI65</accession>
    <name>A0A9Q0LI65_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitogen-activated protein kinase kinase kinase mlk-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_08760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LI65"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5073352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="180" mass="21500" checksum="EBE9440004CD126F" modified="2023-09-13" version="1">MSIHFHQGSDVHSFGLFVWELMTFKQPYKNINDPNGSKYNNDEMIQIFEKSISCYSSLLQFVIRKFFYVCFINGSTRDMEYISELLAMLETQFLSVSENENVNVNVSQKPKNVQMIQSKRNCHFFNCEGNDPKTQTFENQRFSINQIEMILKEFSSKVIFVFLQNLKEMKIRYFYQFNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIG5</accession>
    <name>A0A9Q0LIG5_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_08840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000075">
        <property type="protein sequence ID" value="KAJ5073432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIG5"/>
    <dbReference type="OrthoDB" id="6381660at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040297605" description="Fibronectin type-III domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="917"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="4">
        <location>
            <begin position="148"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="521"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="624"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5073432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="972" mass="110203" checksum="5763447DF3E832AA" modified="2023-09-13" version="1">MIGLKRKLIICFLIINYQILLSFSIKENEEIYWKEKETLFSINGSSWDNFGSEVFVSENFTFIGSKVSINESNQEPGVYIYYQNGTNWIESSILNPNENQLQSHFGSSISSYQDYLVIGAYNQQVGQTRGQGQVYVFQNIDMNWIQKQILIANDGNLLEKFGYSVSIYQDFIAIGAPSDKVGDNSSQGKVYIFQNNGTNWIQKQILIANDGQEYDNFGWSLSISQNYIVIGAPSAKVGDNSFQGKAYIFQNNGTNWIQKQILIASDGQFSDYFGGSLSISQNYIVIGAVDAKVGDNFDQGKAYIFRNNGTDWIQKQILIASDGKTNEHFGWSVFIKNDQLIIGAHFAEVDGKSGQGKAYMFSLNQEYWEETIKLISEDGKEGDSFGNSVGISENYVIVGAYQASIGDNLKQGKAYIFDKIINPLIPQTILENCSSQFEGFECYWNQSSSEYDLFFQINYDSQNWNNILLPKQNGNVIWGEFNSTNYADIEGNSEYSIQIRGCISNSKFCGNSSNPINLTTRIGPIQELVVIPTNETINMEWQYPNVPIINSVPKISNYILSYFQKDEMNSSQIILSNTTNSYTLQNLQSISNYSISIFACRTNECKDEDEGEKTANWITTLFNAVSNLECSISNATEISCIWEEPQEISQSHPSYYNFSFRSEETNESGTFIISQNQYQIKLMETNTKYSIFVSACDSDSKCGITSSISIMTKIEAPEIINFTPQVEGILINFTKVEKAECFQISIDNGSNWERFNTLYLENENYVIGSKSNISGNILYNISIQGCPDSECKCENPGEKSVEIETKVKLGNVQNLKCEPFDLQFSCDWEKLQRDQGLEGYCVSFQNDSEYQFLSKENLSFKPNQNLPENTEYIFKIYASASDSKNQCFHDQFSGKDSFTLVKTKSDSQQNNDLSHSIIITTSIVVPFAVVLIVSIFLIVFFIKKRKTKRKQKEKIDIELENYDNLMKEDVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIS6</accession>
    <name>A0A9Q0LIS6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf-related serine/threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_00764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIS6"/>
    <dbReference type="OMA" id="ARDCDRE"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="544"/>
        </location>
    </feature>
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        <location>
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            <end position="779"/>
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    </feature>
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            <begin position="866"/>
            <end position="882"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5074136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1023" mass="117997" checksum="9875B01898D70B05" modified="2023-09-13" version="1">MTQQVVQLPHSNQIQEIEDNINEDIIEDSDQIKTTKIEDLFTYHIPKLSLHTDHRAGVSLLSGMNLPYKDIYVLDYHVQTDCSALSSMHYTQPDPTVTKNPVWHKYEITNTSTIPFTTGPVMIFQKEKPLAQSMITYTPPKQKVRVDVTIAVDIQPKKINVQEVGRKLKHYRKDSYDYALISNKAQLGISNFAGKDVTFELTLVVGGKVTKSNENGQITVAGFRSDDWISGYRADFNNSSTILWCVVLKKGETKNFEFDYEYFIRKNIEENLNAKQENKKEISGDEKDNKEIVNQFDSDNNESDKDDDNESDKDNDNDNENESDKDNDNENENENESDKDKDNENQSKNQNQNQNQSKNSNQNQFKNSNQNQFKNSNQNQFKNQNQNQFKNSNQNQFSNKNSQDEQSNKEDENSNEDDEQTNIFDNLLAQIEHDNSKSTKNDQSLDSKPKPKNSRIPNPQKKTEINSLQNNPKQSKQEVIEQTENNGKVKKEKKKNKSKKAKKEKKGKKGKQSKKSKKRKGKKAKKAKKSEKSSNSQKESSNNQKESDSQKESSNNQQESDSQKESTSQKESDNQKESDNQNQEYDNQHFILTEKPKGIPDPNFDHPLIPDNSLLQRNSSTSTFEVITGPPIDLISEVFDNDENPKTQTKKSTLKHKKSRKSRKSRKSGKSEKSRKLEKSEKSEKSNDKSGKKATKKKKKPKSIVKKSEGKKDKKDKKDKKDKKDKKDKKDKKGKKDKKDKKGKKDKDKKDKKGKKDKKDKKDKKDKKDKKDKKGKKSKSKEDKDKKDKKDKKLKSKKEDKSKKGKKSKSKSKEDKNKKSKSKGDKDKKSKSKEDKDKSKKGKKDKKTKLKSKKEDKSKKGKKSKSKEDKDKKTKSKEDKDKSKKGKKSKSKEDKDKKTKSKSKEDKSKKGKKSKSKSKEDKNKKSKSKGDKDKKSKSKEDKDKKSKKGKKLKSKKEDKSKKGKKSKSKSKEDKNKSKSKSKEDKDKSKKGKKSKSKEDKDKSKKGKFKFKIKIKIKIKIKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LIU9</accession>
    <name>A0A9Q0LIU9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat ph and sec7 domain containing protein secg-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_01630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LIU9"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="22"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    </feature>
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            <begin position="993"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1089" mass="127226" checksum="94724D36367186BA" modified="2023-09-13" version="1">MDIREAIEQNDIHFLQNLENELQEELTTQNNSFFHFALKKENITFEIIKFLIEKGADINSKDDYNQPSLHLACRNQENENSFEIIKFLIEKGADINSKNDYNQAPLHLACQYQKNQNSFQIIKFLIEKGADINSKNDYNESPLHLACQNKNENSFEIIKFLIEKGLDINSKNDYNQTPLHLACQYQKNQNSFEIIKFLIEKGADINSKNEKNQSPLHLACQYQKKENSFEIIKFLIENGSDINSQTLRDEIALHLACQYQKKENSFEIIKFLIENGSDINSQTYYNESPLHLASQYQQNENSFQIIKFLIEKGADINSQTNYNEIALNFACEYQQNENAFEVIKLLVEKGSDINAQSYENNQTSLHLACQYQQNENAFQIIKLLVEKGIDINAKTYDNEIALHFCLKNNNKNSFQIIKFLIEKGSDCNIKTESNETLLHLASQYQQNENAFEIIKLLVEKGSDINSKNENNQIPLHLACQYQQNENSFEIINLLIEKGSNINSKTLRNEIPLHFACQYQQNENSFEIIKLLIEKGSDINSKNENNQIPLHLASQYQQNENSFQIINLLIEKGSDINSKTLRDEIPLHFACQYQQNENSFEIIKLLVEKGSDLSSKIKSINETPLHFVCQYQQKENAFEIIKLLIEKGSDINAKTIHNQTALHFACQYQQNENSFEIIKLLVEKGIDINARTNKNQVIGLHLVYQYQNQNTMEIIKYLIENGSDINSGNYNNKTILNLFCQDQNNENSFEIIKYLIEKGADVNHKDHFNQTALHSTCKYQNEKSNEIIKLLIEKGADINARNNKNQSPLQIANSNHDRKKIQILLMNDADIFNIEKQQITQEIMDIFPKIYSINQDLNNFLKSNENFPDFQIKSNDSFNFNLHKQIILLRFDNDYSILNKFVNICSQKSKEIVQLCINFLYTGFPDFDNFIEIFHNLINYKTEKYPKLNNISENEIIEEFFKEIGLDLNWINIKKGRKGIIKDFQKFYQENESKNFTIICEEKEVKVHKLILMIRSELFKGMFLSVEDSSNEVHDYTGKTFETIQQLIYFIYNDEIEENKITKQIIQELEDVKDYYQLNQNSFLDLILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LK21</accession>
    <name>A0A9Q0LK21_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase isoform e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_00886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LK21"/>
    <dbReference type="OrthoDB" id="10655237at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="242" mass="28414" checksum="3366DCDCB1A203FB" modified="2023-09-13" version="1">MLTKLEAAQILSELHKSPSVQLLFPKNQYLDEKKEKTYEEIPKVLQITNGLNLEQKINIENKEKKQKAESRKKKKSEEEIEIEIQEEKEELLIKRTRTSDRTKKKSSRINQTNLSEEEKLTSRRNENTNQYISKAIRSASENNKEKVINFLNQTPKPGVSARLDFYSFLFPHFFEGWNPQTTQSGDLPLKVVIKNDLFVVLSLILDKKPKNIKRGISEFFKKRGLKNCTKYCRKSVCFMRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LKN7</accession>
    <name>A0A9Q0LKN7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000077">
        <property type="protein sequence ID" value="KAJ5073163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LKN7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="490"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="621" mass="72469" checksum="394F7171990DED17" modified="2023-09-13" version="1">MNDCLFFGQNQNQILFKNEPYEITKPIQFKFENENENENEKQIKQISSSNFSTIFLFKNGKAIEYSNQNPSKIQIENIQKVTVGCSNEAILTIEGNVFAKEIYINPKNPNEFINISSLIEDINDRIIQDIVSGCNSIYLLTSNQNAYGIGSNYWSQLGFDSKTLEKTEKPILMMKNVSKIFSGNTSYHVFLLNSNQELFGCGVNTYSQLGLGESRKEETKIQKLTKIQNITKGKIIDIQCGNSYSIMLIEIENENQNQNENPKRKLYSCGNYQFNGLGKNGNENTYKFTEMKSSLFENDDILDFSVGYGHTLILTSNSKLIGFGYNNHGQLGTENTNDQLIPIQIELPKLRFNENISNYHISCGSARTFIYYSPPSFSNLEEDLIKLFRRKEFRDISFKTKNGEIIEAHKLILKYRLNQNQNENKIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTDDTSNKVTDYSELSNISFQIFEYWIYSNQIKDEIQITQEIINEIKIGIDYFQLNQTNPNLFDLLINKFNNQNQIKKQKEEIKIKIKKEEKEKGKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLN1</accession>
    <name>A0A9Q0LLN1_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_08510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLN1"/>
    <dbReference type="OMA" id="CHAPARH"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5073673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="37125" checksum="2D8F4DDA1F34EC7D" modified="2023-09-13" version="1">MQFVGWKKLEQKHKFWPQPVNKTQLAYSFTQNKIYFFGGKQVENDDQFDDLYSFSLTTQEWKKEKTKGKKPFKRSAHTFCGFKDTFWIWGELNQKIESKKPEGRFSHSSVYYKGKIYIFGGINFFNNRLNDLWEFDTNTKKWKEFERKGVFIQPRSSHFMEIYNDKIILFGGRISLRQRENAVYFFDLFSNSWSKLDLSEQNIAPDPLSGSSCFIYEDFFFVFSGFSDKSGYTSDFWVLDIHNKKWKKLTNSNQPSKRFGASCVKISPTKFILFGGQDLNSITNNELWVFITQYEVVRDFQIFQNEKILCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LLW4</accession>
    <name>A0A9Q0LLW4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_07963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000068">
        <property type="protein sequence ID" value="KAJ5074920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LLW4"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052457">
        <property type="entry name" value="Ankyrin-DD_containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24125">
        <property type="entry name" value="ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24125:SF5">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="293"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5074920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="392" mass="45258" checksum="B1248F34A861271D" modified="2023-09-13" version="1">MDFEIALRSDDLEKIEKFLPEKVNDYIGLTPIQIACKHQLKEEIIDKIIKSGADLLKKTQESVLHFACLGRVSFSIFSKLVKNGADINAVNGGSILHYACFYKVDPQIIKFLIDSDVDVNQTTGKNALHFSVEKSNFDGIRLLVEAGCDQNQKDNKTPLFLAGEKEKKVIKCSNSYVEDFLRFYERKEFTDVTIKCRTGEIMVHKFILKARISQDETVISRFLTICKKYDYVDIDSFVLFLYGKNFKIPSSETEKFSQIVKDTGLEENWLVQKSGKRGLINDLRKIYYQDQNKDFTIIVVSEFHFKIHKVVLIIRSELYRGMFLTVKDSSDQVNDYSGKSQNAIKALIEFLYFDEFLEQPSDEVFRELYDAIDYYQLNVNSNLLLILGSDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM53</accession>
    <name>A0A9Q0LM53_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphomannomutase 45a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LM53"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="6">
        <location>
            <begin position="90"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="7">
        <location>
            <begin position="309"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="665" mass="78103" checksum="C6802F80850C0289" modified="2023-09-13" version="1">MNFLSSLKSKKTWICVAVTGIIGGIFYYYNHKPNEIAQKWMKLEKNTKIKKEIKTYIENKNWEKLDELFRIEMPLFGGEMIENISTGYVKMNEITISLIGQALCRFSQRKFQEKIEQKGIVIGFDLRKKSYKFAVKIANIFMSQNIPVFLFERPIPTPYLSFSITFLDVLCGVMITGCSKEPNSNGIRIFWKNSSLLSNLSNENILKRVKNNNDILWNVPNQISNATLCKPVLDFRKKYTEEMMKNFHIFMDESFEDLQNRIENENQFIIENELENNENQFIIENENENENENENVQMFKIQESIFHPSEKIIFTALHGISYQEVINLFQALKIEKPLIVESQCKPDKKFPEIPNPNLELGYPVFQKAISMENETGATLILAVDPDGDRFAAAQKIRSNWYFFQPHEIALIFSWWIYSNFRKKYPEIFPSKMVMISTITSASILKEMARVEGFKYYETLPGFHSIGRKASKLKKKLEAVWILFGFDNNFSFMLNSSFLYPDGIASCALFALISKRLALQKKSVFQKLKELERKYGHFYYLKSYFEVKNEEDVKEIFDFVRNNGDYFSKVDHLVVKSVRDVAKNYDNSVHSHQHNFSDFDSKFEMISYYFTNDLTIHILNNGHNLKIEYFIEWKSVSSKKHFENLVQILIKELLEPKLNPKENDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LM60</accession>
    <name>A0A9Q0LM60_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_08507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000073">
        <property type="protein sequence ID" value="KAJ5073670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46866:SF1">
        <property type="entry name" value="GH12955P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="119"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="271"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1239"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1412"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5073670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1541" mass="180880" checksum="146D5E27E3BF5AFE" modified="2023-09-13" version="1">MGQLLTRKEIKFYLETDFKNLIQFHYLKSSHNYGNLVVCHTTFENYLKITQKSKELSKDINSKNDEKSIFPFILQIIPKQKEIKKEFKRQKEIQTNFSNQKKQNINSINLEEYISKIKFVKRKITQIQEYGNIFEDETILFKKNSESDSNGKYLSINFNQISTSLVEKIINILNKNSGVFEVQDIVETNQAVYLFYSHSNYNLQNILQYNQVLIQSVVKKLFIIYQLLKSVSYLHSNNISHGFIKPSNIIITSPKDLWVKIVGLNLSPITPDQYYIHDHKSIFEKWNSHEISNFEYLLHLNHFAGRRMGDPDNHPIFPWLFNFSHDPRIYTSYYSEKKAKKFINYYENLNESVNTSGKSFRNLTISKFRLNKGDQMLDYFFKSYGYHISEGLSEVSFFVYKARQTPIDILKKFVRSNYDPREFPVSMERLYHWTPDESIPEFFTDSSIFQSIHEDMPNIELPSWCSSYQELIHISMEVLESEFISDNLHNWIDIMFGYKLSGMAGFEAKNIAELSFPNFATHGFVQLFTSPHPIRGIFRIHEDEDDEDEYYKYFSENNNNNNNNNNNNAELKKYAQIVSFQKQQISNQNFIELARNEFSSFLQPTFSDNMVVYNNIFYENENQNENENKYQDLFSIGCISLELFTNRPFLTFSQIQKFQKIGRITDHQFKKIPNEIKQMITNILISSKRRELTADEILQSNVFPDYFEPLYDFLSKFHSLKTPLDKFNFTLSNSNEIFKLRKEATWMILPVLTQFFDNPQTQKKSVPLFFQILKKIEDNQSITDLIVPLKKLFQISGCKELSQDLLDPKFLKLVKSRFGMKCFLEEIIPFAIETLRSEDQSIEKIASESLLSVFKIMSDALCFKYAINPLLKILYKQNCKIVVEFLIDLVSIKMKPKDEQEKKKEYISQVVVGRLMELLSQNNKLHLRSGEILLENSLELLHGLISELNREFFIYQFKKKQFDPIFELFQKPILFTNKNTVKLWVTQILAIAVKIEQEATIYYIFDHIGNLLDIFKQVWENQQENNENVIEIDNKDNDLGIKHSISFSTNLHDFNISEHLQEYKNQYTHEIAFMILSHLSLFIDLKMIHSIPHFSFLYSFLDQNEFFHDFVQQTLENQIEEKNSKLKNTEIFANKSMIFGGNYQNNYIDNFNINSRKLIKNSLINIEAKKVPLNNNKNDQLLDFDQSKISEFTLIDKLDFDEVGQKLNAYDWLSRLLIEGYYNTETRGLNFLGKIVQSHQMHNSTIYDLDINSKQNYIATASRDGSVKILRINKSSLACVYEEHKQSVLKVSFLNYGNKIVSLGECVHLWDIETQKCLHKFGTENTTSPFKILTFAYSPMEKTIIAETNTSSIQIIDPRSKKFECSWKLSNPCSGLIRSIDVDESRNLIGVGLLNGDIDMLDMRTGVILNSWKAHDSIISQLKFHDEYLISSANDKKINIWNVHSSTNFFNYYYREPFLMSIMKIFDNSTCFSIVEDHLFSVFGHYLLDTNLDSKRIKMNEVLDTRLIQLEKSSTLRTVNVLDLHKLLLLGCDDGLVHICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMD8</accession>
    <name>A0A9Q0LMD8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pep-cterm sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_00691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000070">
        <property type="protein sequence ID" value="KAJ5074063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMD8"/>
    <dbReference type="OrthoDB" id="7953866at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="313"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5074063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="502" mass="59199" checksum="8722CCE9C534C03A" modified="2023-09-13" version="1">MINYANLEKLSNNLKNLFINENQEENYFDFEIICQQTQKKKPFSFKTHKSILSSRSQYFKSLFNSKMKEYQENKLVLQDFSTSIIALILKYLYSGKIEINLGNAIEILIFSSKYLIEELIEISSKFIKNNLQMETVVDVLELSDSMNLKELFDFSYQFILENFEKLMKTAFFLELEEDRLNSILSNDRISINQFELFQSIIKWGKHKSNINQEKEMGKEEKEQLQNQISDIIHKIRFIDFSKKELENSLKEDLIPNQISQKLIQFQNLQSNYQKNQKELKELIEQENLNLNLNSNLNSFIFKSKIELRTKSSIIQEQEHFEKLKEWIKDNNYFSKMKLGFSAKRDGFGCKKLHSICDNKGKTLVIIKTEDNFIFGGFTEVGFTNDKSKWSGFYRRADFDWIIDSNAFIFSLKNDKNDRKAEMFPIKKSFKKYAVYYDYSNCGPTFGGGYDFYLNHQLKTGYSDFGNSYNLPNGIKQGTKEAKSYLAGSFNKWVVDEIEIYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMK1</accession>
    <name>A0A9Q0LMK1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caax amino terminal protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMK1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052710">
        <property type="entry name" value="CAAX_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36435:SF1">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36435">
        <property type="entry name" value="SLR1288 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="3">
        <location>
            <begin position="127"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="279" mass="32585" checksum="1EEA9DCF91C018A2" modified="2023-09-13" version="1">MDDSNQEKETQIDLQDFPDLPDENPEKEQEQEEQEYLKQQIQENIPRTKYPVILLILDIVLILVFGGSLISSTNPDFKTYFLSKSILLFSMFITLNFVGSFMFFLISIKAKNPEKPIWKVDLVSPNFGIWISISLLPAICEEIFFRGFMQKAMEYNFQNIKKAILITSLIFSFSHFDFSFLGFLYQFLLGYIFGNFASRTDSIFPSIISHIFSNTMVLIFFLHPETSSISPTVAIFFFLLSLAVFILLSYFFIKKNDYIGIHFPNRNLIQRNRSEFEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMN1</accession>
    <name>A0A9Q0LMN1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Single myb histone 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_07406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000065">
        <property type="protein sequence ID" value="KAJ5075436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMN1"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044597">
        <property type="entry name" value="SMH1-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46267">
        <property type="entry name" value="SINGLE MYB HISTONE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46267:SF15">
        <property type="entry name" value="WINGED HELIX-TURN-HELIX TRANSCRIPTION REPRESSOR DNA-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="125"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5075436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="336" mass="40408" checksum="F7DD3E01A626DB7C" modified="2023-09-13" version="1">MGNMIINIEQIKFKNYDEYLPFPVSFEKSIQFRKEITQKLIENTRYLRSLQEQTSKTKKQKKKAPNRKKINKTQTRKKKKQTITEKRGKQKPKQKKNRMQKTKNHQIQQKERKIRHKQSQKEKKTYQSRGGTWSMEETYQLIEGVRRYGVGRWSLVRDDPKIRIGSHRTNHDLCNKWRNLTSRSHDEDFKKFITEAINQKHPVVYHGNDSAEITDDDIEKKSDFLDSSFDNQDIKRTKKSNKKNPQNKIDLPNEIFERQIEALEQQQNENLVEQNFVINQNSRQFEKDLIQKNQDQKNNQKLAVDVVFEKENDSQSNFAENFEKKEEEEEEKEKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMP2</accession>
    <name>A0A9Q0LMP2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_07567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000066">
        <property type="protein sequence ID" value="KAJ5075214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMP2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="523"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5075214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="640" mass="74678" checksum="D8B229522E8D99F4" modified="2023-09-13" version="1">MNDCLFFGANRKPKLIKNKPDKIKKPIQFKFENENENENENENENENENEKQIKQISSSLFSTIFLFKNGKAIEYLNENDSKQNPEKIQIEENIQKVTVGYQNEAILTKEGNVFAKGRDINSKNPNKFINISSLIEDKNDRIIQDIVSGAKSIYLLTSNQNVYGIGSNTDGQLGFDSKTLPKTEKPILMMKNVSKIFSGNSSQSVFLLNSNQELFGCGYNYYCQLGLGESRNEIEIQKLTKIQNIPKGKIIDIQCGDDHSIMLIENQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNPKRKLYSCGYYRHNGLGKGEDTYEFTEIKSSLFEDDDNILDFSVGNVHTLILTSNSKLIGFGSNFYGQLGTVDTKDQLIPIQIELPKLRFNENISNYHVSCGYFNSFLYYSPLSFSNLEEDLIKLFERKEFCDISFKTEDEEIIEAHKLILKYRLKQNQNQIEKLQEIISKKSIKESNQIFEMIYSNNSKINPKLYSEIKEIINSNEKIEETIKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYTNKIKDEIQITQGIIDEIQIGIDYFQLNQTYPNLFDLLINRFNNQNQNNNSKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMU2</accession>
    <name>A0A9Q0LMU2_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/arginine repetitive matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_06446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LMU2"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5076446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="768" mass="92837" checksum="063FC2AA6864F0F4" modified="2023-09-13" version="1">MVYKKKIFVQILENLSEEEIRTEFNKIGKVTKLEIFSFKEMLLAIVVFKKRISTKSIKNLENILEKEIDEIFPQCILCNKKTPIPMTMKCPFCSDIFCCSCLIKIFNENQSICPSCQNEINILEYLQNDQEIINFQNSTKQMDSSKFLETKNLLTNEVGKMQQKIEILLAELQTKKIHLHNIRNENEQNQENQFNQNQFNQQNEFNQQNEFNQENDFNQQNQFNQENQFNQNQFNQENDFNQQNQFNQNQFNQDQFNQDQFNQDQFNQNQFNQENDFNQNQFNQENDFNQQNQFNQENDFNQENDFNQQNQFNQQNEFNQENDFNQQNQFNQENQFNQNQFNQENDFNQQDQFNQDQFNQDQFNQDQFNQDQFNQDQFNQDQFNQDQFNQDQFNQNQFNQENQFNQNQFNQNQFNQNQFNQNQFNQDQFNQNQTICNFFADPNTAWCHAYQHWKNRESQPQLHPQEESICIMLSKCKDYPNCRYNHPNPLRKDFQKAWNTYQGDEKSFDIKKRNSFYRDTRNERIKTICQNFVKYGKCKDLNCPFEHVRINNQRIPVKKVNQPKKNQKKQLNRNPNPNSNPNPNSNPNSNPNPNSNPNPNPNSNPNPMKQLNPNPNPMKQLNQKRNPNPNPNPNQIKQLNPNPMKQINQKRNQNPMKQLNKKRNQNPMKQLNKKRNQNQKRNPNPNQMKQLNQKRNPNPNQIKQLNPNQKRNQMNQKRNPNQIKQLNQNQNQKKNQSKSSLSLEWKFFYFILIVVFLLILFQIISSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LMX4</accession>
    <name>A0A9Q0LMX4_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beige/beach-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_07141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000064">
        <property type="protein sequence ID" value="KAJ5075571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="7">
        <location>
            <begin position="2517"/>
            <end position="2617"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="6">
        <location>
            <begin position="2626"/>
            <end position="2916"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3058"/>
            <end position="3089"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3105"/>
            <end position="3146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1268"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2140"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2176"/>
            <end position="2216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3303"/>
            <end position="3329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2445"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1297"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2176"/>
            <end position="2188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5075571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="3329" mass="391453" checksum="27FA2CDA401D0C6C" modified="2023-09-13" version="1">MSNKKNLFAKNKKFKIFQKTPQEDPSFKHHKLNGEQLDTIWATLKTIQNLEQTDTWFCNFSELFLKSYSDWKPSQFTSLKKMESISQKLYEKDEAHPPKLIVETLKTLYHFTQIFTHDPNLLEKESSSLISIEMILLLSKSVYNQKCFIKYQLFQILIIISEQFNSKISLIFDEMQTKDETKPKNSFTLKLVHLLQYLLSRITSIISIFHRSILFPKLNSNELSIITQILFHFLLTLVQLKQKFRFNKEQYDILFDMIELFRKMTQKSILKNEHLLFLFKTITSLLEPPKPTVFFVEDHFKDENEENDTNSLSRHLFQHFLLKNQKLDEKELKLIDFQTKIVCIDLIRFIIKDNIEVEYLFCDSMPLTSFQKFITWVTHQFPNTETTNMRNEKKHSQKENNENNHDNTQDANALDKEESKEIENTQLKFSKEVPIISADEIKEEIEKPQIPLKFMNNLRMEQLFVSLKEICITSQKNRNAEQLKKLQIMQKKKSKSQNNQQSTKKQKQKQKKKKKKNEGFQLEDLLKREYQFAIEQNHQSANYSNLNFHFHHLLYNLFVERTSFRAKDQKMLNLYILNFFLDIFSEEFSDIFYKNQIWKVMILKVCEEDKILDKIIKKKLHDFFCYFQSLYPKQKSQISVLFEIMKENKENAYIIKDMTKLIIKLLRIDFGKISHELVEMDVFNFYLETNLQLLKMKSVEQFQAAFNAKSVSSEIYYKLQYKIFKVLDYLFANEEICIRSLSNTSWGISIISLVFEKSTKKLSLSIMFRMMCSVKSTATADMEGWFFQMYMELVMTISQRYTSKPLEYSITPKEVVQTNSIDDSKNTIKIPSTLPEYPIVYIQELLSLATEAISINRESLQKLLPQIGIFEMLISLMSIPELNTIVSRFILRMLNELLYCSKINVDRFNKISGFKNLGNLLLDSQQNNSDVEIFQLLLSMIVNTGKFDKENNYLIQNYYLVSMMFELYYKLEDHSFFSQLLDIFCEICEKSTQNISFCYTARLLEHLSTAVCTIHEDLILQKVSRLIKIICSYGITIEDMHTLFRPLAKLQENKKLPYLVFLFRILHGMVEKSEHLDQPLGFFDFHFGHLSLPNVEKWPNNGWGFYTWMRFERETINSTVSLDMQPRIFSFFDDSGKGIEFFFLVKDSQKTQKQSQDNKKKDLTIIFVLRVLTPTDSAEVAFPFDFPQKQWNFVAVSQSPIKGYSSSSKVRVYLNFEMAEQAFSKYLTVPDLTKNKVGSRSFFETPFPNSYGPKMNFYLPKIKNPISGENEDFSETKPKRKSKAKHDNSSPQTDAKIQGKSDEGNKQEKSGGWDQKERLKQLTPTNSLESYSIPQELGHQNQIYQKMEWDYSFVGEMGIVCFFKKSMENSHFSRICKSGPQFIPFFDVSGVTVPVTTDPYIQFVIELNQSILLAYHPKATKKHYCLDLSPGSTKKSSAIMSGVASLFFYDLKGLITSLGGISIFFPFFIDFEQLFPNFRDSIFSSEEIEITHLDYIFSIFADILCSTKEMQDSFVEEYSFALISKMIGDVDPLFISKKIVSVILKMLLQARSTKFANDLFFNLVLSIDNWIYCSFEIHKGLLGIMTNVIKQDLDNEMLKEIDVSIQMLIDILTFFYWLKPEEFSRGTEPKFFPKTNRYTNRELSSKEVTELRSMILILIYSKLSKLRTENTENNRKQIKESLLLVIYSFCILQHKETYFGELGMFVGFLLQESKTNSKLPQAPILDTALINPLVFLLDTHESPSRRKLLEFIYDLDTLGLQISEINSKFDPKRGYIIVNEILLKYELTKDLSHFLFQIMVSPSIPAPKVGNDFEIQRPWVFFTILKFIKKDQNSEALLFANKVLDIIKKQNKNPKGLLDAFGWQFRLIELVDFDNVVEREQIFYRKRTTSEETEDEVSAKKNEANDFVFDFFRWILSYNLLNHKTGLQFLLQTIAFVGLSTISKHKYEEIVVRRILFDVFQEIAPNIKDLTKKSNTFIFNNIYGLVEVVRRYFYFDFSYEIVKLDTPTNEMPAKKSSEPSAEEEKRERIKVKCRTKHTHIDDFMLISGAMDFFEKSNFWIKFALSLDDKKKMQVFTRNLIILIVHFLPSLDSHICHFYIDQLNILINLKMDDKILIDIIAILFQYLRLYSNIALPENTETNLERPSFTEEDTDQTQKFNEDDPKKSEEFFEIDLGSDNENYNDNDNDNDNSNSNPNQAYDMLSSESTTETDRRNESMHDISTGNIFLDFVSGETRKEIFWLLVSIFENHYSILRPIILDEENKVIMSELFSKTHGKELNGNDIITEETFHTKKWRFAWRKYFLPRILRMKKKNIASLGHINKQIAIYLQSSRVKLYEENVQIFQQKKIHHRVVIGRTEKRLSKIRERMKFLQVLENRKNRSMIKKRKRAFRQLISNKFLWYQVLPKSKEYFRYFKLDKTEDLSKTRPKMRINYNYDSHFDALMYMNKKKFEKKKLKLKIENQNQNKNNENQKIISKKEKDSENKIKTVNDFEIYELEFYRSGKKNQDNILKEVLENMNKAINTLAVECEMISGLFKYSGILEITEMEMNFYIDFKDSGNKMHIPMNDKKWKLKNIIEVHRKRHNFQPGSLEIEFDNHKSYFFKFSFENSNAVFQKLSDSKLTRFNRDPDLVEELRNLTKQWQNYQLSNFDYLLKLNFISGRTFNDLSQYPVFPWIFSDYECEELDLKNPEVYRDLSKPIGALNPKRLKIYSERYTNMIENTDGLPPFYYGSHYSSPASVVFYLIRLEPFTTQCIYLHGGKFDHPDRLFHSIPLTWRSCLSNSADLKELTPEFFYFPEFLLNQNNFNFGIQHTNQKVEDVELPKWAKSPEDFVRINRKGLESEHVSETIHMWIDLIFGYKQRGEEAIKAHNVFYFLTYDNIDFDSITNKEELNTTFSQIENFGQTPKQIFFKPHPQRIKKVTTETKKPIPIQEIFNTISIFSATLSDHSIVYVYLSHQTTELAWFGMLQKLYLIDSKRNFFVKKWALSKSNTQQAPVVNLESEKSAKNSKMIGTVFAEGVNYYNCFSIAPSGDLLFSCGFWDNSFIVSNSENGVLVNRIVHHKDVVTCIKTESNRLLATGSRDCTVVVWDYDLEKRPLEIIPRYTLSGHRSEVTAVAMSSVWDMLVTGAKDGVCIIYSLYSGSFFKKFKIRNPSKVLFVPGTEHNNVEISMIRILSNGQILVYSINDPLLSLYSHLGRFISNIPLSSPITSWEFIHDEEFLITGSRNGLLQIFNIPNLSLVHDYNIQTPICYICITPDKDNFLIGGTKGALLIGNLVSTFTFQIRNQNQNQNQNQNQNQFQNQNQNQNQNQNQNQNQNLNQNQNQIQNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LP28</accession>
    <name>A0A9Q0LP28_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine-protein kinase fhke-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">M0811_06367</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000061">
        <property type="protein sequence ID" value="KAJ5076368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LP28"/>
    <dbReference type="OMA" id="SAYFNTI"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="156"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAJ5076368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="448" mass="50866" checksum="304CEE11799F75F1" modified="2023-09-13" version="1">MSDKEMNEDSDTFSDAEPDDSKPETVEKSQEPWGKLVSLTKGFPNFNLISNDPTIFGRLDNCNYIIADPRISSYHCSIYRTIDTTSQASPFIVFLKDQSSNGTFVNGKVVGKGNQVKLFHSDEISFVYARGGKSAPINFSIIPSDHFDESKLYERYEIKKQLGSGQFAVVKLIIDKITGEEFALKIIDRKKYINPQKTVKSGRNKLMDEVNILRRLHHPNIVNISDIYLTERYLYLVLEYCAGGELFDRIVERSRYNEEDSKAVFKQLLSALIYMHRKGIVHRDLKPENILVSSATDHTAIKIADFGLSRLVSGDEKMQTLAGTTHYLAPEVVKNANRRKGYSKACDMWSAGVLLYILLSGYMPFSEDRPSRKPLVLQIVEGDYDMSPNRFKGVSVAALHLVRRCLTVSPQFRITANEAMEHPWILGKSDEITDQFQKLPNPLNKDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LPQ0</accession>
    <name>A0A9Q0LPQ0_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">M0811_05974</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LPQ0"/>
    <dbReference type="OMA" id="FCAGFIR"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000592">
        <property type="entry name" value="CAMK family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="383"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAJ5077451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="444" mass="51181" checksum="A3B5799DB5712263" modified="2023-09-13" version="1">MEHQLKNYFVCETIGEGAFAKVKIARHILSNTKVAVKIIDKKAYAQNSDSLNRLQIELNALKLIDHPNIVKLYETVNTKKYFYIVTEYVANGELLTYINENGKMSERKARGFFKQIVDAIEHCHQLGVAHRDIKLENLLLDANNNIKIIDFGLAGEMKTDNWLCKTACGSPSYSAPEVIQGKRYQGKKSDVWSMGVVLYAMVCAALPFNGKNVREICENIVIGEFSIPDDISQSCKHLIRHMIEKDTRKRYTVSQIKLHPWFNEQDTDSPRFIEIPTPIKELNHAQIDPMILKQMEQAGFTAKQVAFSIQQQRFDSSTATYRLLLDKRKNENSPRSERIVKTWKIQNSHLDTNIDITNTIDLTDTESSEEIDLDEINEAQNKKMEKAKKENQNQKNQNENQKTNQNQNQKTNQKNQKSKKPIPENKSKIKKQIKKIKNQKNQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LQ05</accession>
    <name>A0A9Q0LQ05_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related c3 botulinum toxin substrate 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000060">
        <property type="protein sequence ID" value="KAJ5076570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LQ05"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="236"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5076570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="436" mass="51495" checksum="E714614501499B75" modified="2023-09-13" version="1">MQKYKILFVGDRGVGKSTALFVYDHNKFPELYIPTVYDNFEKKFQIEDKETILQIWDTLRTEDLDRLFPLYYLATYLIAIFFSIDSNNSFERVESFWIPDIEKHAPKNSKIILIGTKIDLRNESKEENKKLITKEEGIKLAKKIKAIKYFECSSLNQKGIETIFNEIALICFGKYKEINQEKENKKGLLFIGTAGTGKTSLLLTYNEKKLPEIYIPTVLEYFEKNFKFESGNKLENKLENQNQNKLENKLENELENQLENQLENELENQNQNQNKLENQNQNKLENQMKELKINFWDSARNPDYDRLFPLYYINSNVIAICFAIDDYESFEKIPTFWIPEIEKYVPKSKIILIGTKIDLRNNEERINELKEGNKKLITKEEGIEMAKKIKAIKYFECSSLNQKGIETIFNEIALICFEIDQEINQEKEKKKRCILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRA2</accession>
    <name>A0A9Q0LRA2_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_06677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000063">
        <property type="protein sequence ID" value="KAJ5075815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRA2"/>
    <dbReference type="OMA" id="SAGYMEY"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5075815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38681" checksum="5D2234E14D973DD1" modified="2023-09-13" version="1">MSENYFLYATGFNENGQLTLREKQIITYPQKIEQFGEKKVILIAPGYENVLYLLENNELQQFGISNENHSKFFEDKSQIKNIKAGQDHFIVLTEDGSVYWWKAANSNSIYNESTTPKSPSLVLLNFPVKEIIAGGHSSYFLLENGDLFGLGANNQHQISSQEKQFFDEPILISSNVERAFSGCYSHQVFFIKSNKKLYCRGYNQYGQLGTGNTKNQQKDFHLKFFRNQNIVDISCGYCHTLIWIDSGKTQSIYSAGYMEYNGLNQDSHSTKFKRLLKYQDKRIIQISSGSQFSYILIPNNEFIVFGWNDDGQLGTRDNVNIKQPKNNKLSRIPKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRY1</accession>
    <name>A0A9Q0LRY1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase gin4-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_00132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000059">
        <property type="protein sequence ID" value="KAJ5076815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRY1"/>
    <dbReference type="OMA" id="IMCENIL"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5076815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="227" mass="25840" checksum="10C7254F9C993B33" modified="2023-09-13" version="1">MEEGELFDYLVNKGRITHEEALCLFQQIIYGLEYCHNHLICHRDLKPENLLVDKKQNIKIADFGMARLINAGSLASTSCGSPHYASPEVVRGIPYDGMASDVWSCGVILYALLIGRLPFDDNNLTKVLQKVEQGVYTIPNTLSQNKVDLIQRMLTVDPKQRITISEIKKHPWFRSNFPDGYLPPSIASMKHKTNKPINFKEMPKEILSYLKSLGSEEPNIEKFLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LRZ9</accession>
    <name>A0A9Q0LRZ9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat and btb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_05740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000057">
        <property type="protein sequence ID" value="KAJ5077641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LRZ9"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5077641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="197" mass="23887" checksum="15C11F98D1CB83FB" modified="2023-09-13" version="1">MIYSNNSKINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIEREEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIKIGIDYFQLNQTNPNLLDLLISKFKNQNQNQNQIQNQNQNQIQNQNQIQNQNQNQIQNQIQNQNQKKRKEKCLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSK0</accession>
    <name>A0A9Q0LSK0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSK0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="208"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="498"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="601" mass="70100" checksum="8358633A1969B1A4" modified="2023-09-13" version="1">MNDCLFFGWNQNPKLFKNKPEKIIKPIQFKFKNENENENENENENEKQIKQISTSYFSTIFLFKNGKAIEYLRENDSDQNPSKIQIEENIQKVSVGVENEAILTKEGNVFAKGNDINPKNLKEFINISSLIEDLNDRIIQDIVSGYSTIYLLTSNQNVYGIGLNQYGQLGFDFKILPKTEKPILMMKNVSKIFTGNCSNHVFLLNSNQELFVCGDNYYGQLGLGESIKEETEIQKLTKIQNIPKGKIIDIQCGYTHSIMLIENQNQNQNPKRKLYSCGDYQCNGLGKNENTYEFTEIKSSLFENDNDNILAFSVGHEHTLILTSNSKLVGFGDNFYGELGTGNTINQLIPIQTEFPKLRFNEDISNYHISCGFFNSFLYYSPFLSSFSNLEEDLIKLFRRKEFCDISFKTKNGSIISAHKLILKYRLNQNQNQNKIEKLQEIISNKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETIKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDTSNKVTDYSELSNKSFQIFEYWIYSNQIKDEIQITQEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LSW9</accession>
    <name>A0A9Q0LSW9_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LSW9"/>
    <dbReference type="OMA" id="RFPERCE"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="192" mass="21822" checksum="DB713120045272F3" modified="2023-09-13" version="1">MSEHKYQVVIAGPGSVGKSAITLQFISQQFIRDYDPTIEECYKKHIFVDNEVAYLDILDTAGQEEYSSLRSHHFQNGDGFLLVYSCDNRKSFEEIGEFRDEIIRAKDDDDVPIVLLANKCDLPKTDQQVSKKEGQDLAKSYGYSFLETSAKSVINIEESFAQCVREIRKKRAVNNAPQSTTGGKKKKKCYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTC5</accession>
    <name>A0A9Q0LTC5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sad1/unc-84-like protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_04917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTC5"/>
    <dbReference type="OMA" id="CANSQVE"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="729"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="488"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="894" mass="105306" checksum="D3B305EE9B6C5F11" modified="2023-09-13" version="1">MKQIKNFYYYTTREIIGFWRLIKLGIYIVIEFFISLETYLTNRIFSFLKSALNFRGDNFSWRNSIILLFSLLALGSILGSDQIQQQYRLSKEKEFKRFLVNSANEEIRYNLLKNVSIFTPAKNIDKYVSGIAEIIKTDIDNLIEGYKVEFTNKTLEEKQKLTAEFKSKIKDLLEKEEVKKQIQFCIEESGFVPSTRIVREMMKNVADLKKEIKMKTKTIQKLMKQNSEAISTYGTRIEEGDQQLEKIKNSSNEMYKQNINLINQKTELVRDYFNDFSEQFKNYNSDLKKAEQGIEDIWRITNKSYSLLKLFDCLFERTEEHDFSNEIEALKEHVAKKFIEIEREMKKTNDSMNEMEKKQDKEGSDIQNFIEKIQENIKQINESQPDENKLESLEKMVEKFHQDFQTNLKRNEEELETIIEQTGTVQKELPELENSLKKLFATHTKKEDIQNEMNKFSDLFHEFDDKNKNITDTLENVKKTFSNMDNYVDEFNKKFEEMKKELADTSSEMNNVENEKNEKNKEFQNKFETLKKQIEKLQNEEKEIQTIMGSLDNFEKEIEDISKKVDNLKIIPGSDSKQFLEELKNMREKFDVLQDKTNEKYALLEDDLKKKFEEKWDDFTKNEAELMEKLKADLFEHLENKKKQDVPDELENEIIENKIGEVFERIKEDLYKDSMKRFFEDDQNGALKEFESYYEDLLKDISARVLKNVSDLIQQDFVGKIDYALGSSGAEVISHSPVYSSSFGSRFNPLSYFHQFLSVLKNPKLNHPELALNPNNAIGNCFGFWGDKGFLAVRLFRKIIPTQITIEHVPKAVSPDFSSAPKDFSIFAYSNSFDSDPIFLGNFTFVFDDSYLPQTFNIPDNLQVPIEVVKFDFNSNYGKEFTCVYRVRVHGNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTM0</accession>
    <name>A0A9Q0LTM0_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Division protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTM0"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF21">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 WD40 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5079731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="558" mass="63441" checksum="3D4E3A89046A9C20" modified="2023-09-13" version="1">MRGFCSICHQFKQNGVTIITQEIIQNLPHNKRYEIGKLICFECRVQDKRPKIQTKLSQFFKSSSQTEEKTLNSQTNESNIESNSQSNIEQNIKSNSQSKLEPNIGITIQFNKTQILQNSIKDINSQKISHLLNNISTIKFSNSKIDRKFMNQIKTLTKPKSKFTKNIKYSQIPFEIQKSNTSLSNLDHITSVAFDPKDGSLISSSSSNGSIYIFDFQHYLTNSYFYRNQEKIPEPALTLKTGERISSLRWTGANEIICSFHSSPKLYAFDLLSCEENTPTQIFLTNPNKQTHSLNDIIFDKELIFGCGRNGGFVHWDRRVSIQKPVKHVLFNDLGTINSIVLVGNYLYCGSQSGSISVHDIRRNFKIVKNNMVNPKQNQPIDTLVLEPESQLILGFQLSTGNIGFFDLFTSKIKLYQNHSIKNRTRSKTALLRKHLINKSGKSHISGINSPVISRVEFLDTNLAISTEKELPFSSYYRKKPCFVKQDDSSSSLFVFSSDRRSVNLVDFTDLDHSKPLSFLSSSLVISFDAHPITNDFVGGSVFDSLFAFSDDFINIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LTM1</accession>
    <name>A0A9Q0LTM1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein rab-32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_04806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LTM1"/>
    <dbReference type="OMA" id="KITLQLW"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001800">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="204" mass="22988" checksum="F20419C1D7F5985A" modified="2023-09-13" version="1">MTNIEQAELFKILIVGAPGCGKTSIIRRYTEGHFTPNYKSTIGVDFATKELSLSKHKITLQLWDIAGQERCGAMTHIYYKSAAFAIIVFDSSRKQTLEEAAKWKNDVSGNAFLPNGKPIPMFLFANKSDLEPEVSQESIEEFSQQNGFVRWFFTSAKEDTNIDEAMRTLAQDLIELDIHPINREGVNLRDNSDQVKKKTNSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU47</accession>
    <name>A0A9Q0LU47_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_05212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5077955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU47"/>
    <dbReference type="OrthoDB" id="408439at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220:SF1">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX COMPONENT C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36220">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14312">
        <property type="entry name" value="FG-GAP_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040294035" description="Fibronectin type-III domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="897"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="512"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="614"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5077955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="951" mass="103133" checksum="9C727100291BF7FF" modified="2023-09-13" version="1">MKTTQKIFSIFCFFSFLFFLTSNSILQFELTSIDGQEGDNFGFSNAIEGNYAFIASPKATVGNNSEQGKVYIFQNNGTNWNQLSILTASDGQSGDEFGCSLAVSQNTLIVGAFSAGLWNSTNQGKAYIFQNNGTNWNQLSILIASDGQPYDNFGYSVGISGSNAIIGAFFASVNNQSQQGKAYIFGNNGSSWNQLSILTANDGQSGDQFGWSVSISGNYSIIGAPYASVGNNSAQGKAYIFGNNGSSWNQASILTASDGAYSDNFGYSVGISNSFGIVGSPKVVYPNTTNHGKGYIFNNNGTTWNQQQILVPTGVDNFSSFGVSCAISGNWIIYGSYGSSEVTNNSNGNAFVFFNNNSTWNQSCTLSPSDGKNGDHFATNVALDSSSFLVGAPHASVGNNLLQGKSYIFLPEILPPQVNIENCTSLFSKFSCTWDAIDISGIQYQILYDQFWINVVNPVQNGSFFSEIFSPPQYPNITGNLFYSIQMRACNPILNICGNSSSSWNLTTRIDSVQNLSLVSLPNISISVSWKSPHVPLVNSTPKLDHYLISYQSSSSPNATQMSLTNTTTSVLLQSNLTPSTNYSVSIWPCQDQQCSGQSQGEIATSFICTFFGPVLNLTCSLSNGENISCTWNPPTGSATPYDYQFVYSANSANDSGSFSPNITNQTFTAKFYTEEYTINVSACDQNGNCGPVSMFSINTSLPAPNMISWTYGIEEVELNFTKINGSQGYLISLDNKQTWENFDYINSNESYVYGVKKNVPGNVPFVSSIRACSESTCNLSLAGSPSSVFVLIAQLGNITSFDCDGEDDEIECKWHGLNLASGLGGYCFTLNSSTVYLNPNQHKFEQENLQVYQTYFVSVYASAFQNCSASNYSGIPNSKYVTLYPESESSSSGTKAGVIATAVVVPVVGVALIVGVVLILRKKRNRYKKFDDQSNQELMISDNEDYQREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LU65</accession>
    <name>A0A9Q0LU65_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_06036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000058">
        <property type="protein sequence ID" value="KAJ5077513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LU65"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="3">
        <location>
            <begin position="348"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5077513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="535" mass="64119" checksum="2D891497FDD3AFF5" modified="2023-09-13" version="1">MDNNNNNQIENANQNQNENEMKNLEKKVTKNLIEDYSNLLNGNSFKDFSIFVENKSNPFEIKVHKSILSSRSPFFNESLRQESLSIFLNQFNKKEMESILSYIYYGNISFENQENLIQLLEISIYFKLNLLKEIIQKKILNSINYSNFFQFLFQNRNLNSNEIEIKCFELINQNFSQIQNNENLFNLTKEEIIKFIQFKQEKKEIFQFDFFQFLNNWIKKRNERLKGKKYEHKMNAKKRLFHSFFSLFDKYSISKQDFDKLKQFEIFPKSFLVDIQNKIIQDNQKQEKKLKLKRKEIRLKNHEIKDKIKEVEKMKKEIEDKWKKEIWNIKERQIKEIKKNFPQFEDSEIVKDIEYVKKLQEWINDNDFFSKMKKGFSAKRDGFNSQNWHKAVDNKGKTLVIIKTKDNFIFGGFTQVGWTNDKSKWNEEDRNDDFGDIIDPNVFLFSLRNDKGDRKPEKFTIKKGKEKFAIYYESEFGPSFGSDCGLNSKLQPGESNFGSTYNLPNGITYQSNEARSYLAGSYQSWVVDELETYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LV06</accession>
    <name>A0A9Q0LV06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bonus isoform c-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_05178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000054">
        <property type="protein sequence ID" value="KAJ5078390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LV06"/>
    <dbReference type="OrthoDB" id="295536at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5078390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="636" mass="68269" checksum="A3E6653D6AAAC8BD" modified="2023-09-13" version="1">MELSEQLSKLLYCSNCKQAFNNDAHWMPTCMHALCSKCLNKALESKPVEEKDEPDEFATILTCPICKNAYKLEDELQEELPTNEILNFVSKLYSQTAKEKESICEECGVNMAKKYCRNCQKSFCPECTEKIHSFKSFQKHEVAELSLTTPTHNDSIFACNEHPTKQKEYYCTECETSVSRVSRKDPICDLALLLKKNSLVIDSLEKKSNEIDALLDIANGVVPTAKLKIQENLEKAAELLEKRKIQLLSDLEIISHSIDSHLRKFMTTFDRRSKELELCEHVSKSILDSQTSSALVYELESALQKLQNTEELVSENISAEDFSVNVDFDGIEKFFDSLGYIDSPSFNLIGGPGVMEITGAKELSGEIKCTKLIIKANAVLTVKPWDGTSGGVLKIFAKSRIIIEKGGKIDLTGKGYRGGEAVPQCYDGKAKQGESFNGKGGDLQEANKGGGGAGLGTSSFGGYGGGGGGYGAKGDDAEPNRYSGQVHPGAKGGETYGDEKITELYMGSGGGSGHPYSNGQTKGKGGNGGGALLLQARLVLNEGEIICDGEKGEDSVPNTYGSGGGGGSGGSILFITKLLINNGSISAKGGEKGIANYSSSPGINSSGGKGGDGRIAIKGLRTKGAPSVPNWFLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVM5</accession>
    <name>A0A9Q0LVM5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">M0811_05398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000055">
        <property type="protein sequence ID" value="KAJ5078140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVM5"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="240"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="354"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="521"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAJ5078140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="626" mass="73198" checksum="AA04C9F842F6AB85" modified="2023-09-13" version="1">MNEILFFGSNQYPTLIKNETETTIIKPIQFKFENENENENENENENENENENENENKNENENENENEKQIKQISTGYLSTIFLFENGKAIEYLNENDSNQNPQKIQIEENIQKVTVGYQNEAVLTIEGNVFAKGKDINPKNPKEFINISSLIEDTNDIIIKDIVYGYQSIYLLTSNQNVYGIGSNKFGQLSLSSKIIIKKHKNINRKIRKTEKPILMMKNVSKIFSGASSEHVFLLNSNQELFGCGKNNHSSLGLGFRKKQIRKLTKIQNIPKGEIIDIQCGSDYSIMLIENENQNENLKRKLYSCGNYLYNGLGKDNDIYEFTEIKSSLFENDDIILDISVGYYYTLILTSKGKLIGFGLNNLYQLGTGDTNSQTIPIQIKLPKLRFNEDISNYHIYCGYNRSFLYYSPPSFSNLEEDLIKLFRRKEFCNISFKTENGEIIEAHKLILKYRLNQNQNEKLQEIISNKSIKESNQIFEMIYSNNPKINPILYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLYVTEDKSNKVTDYSELSNKSFQLFEYWIYSNQVKDGIQITKEIIDEIQIGIDYFQLNQTNPNLFDLLINKFNNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LVX7</accession>
    <name>A0A9Q0LVX7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-protein coupled receptor 157-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_14207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000015">
        <property type="protein sequence ID" value="KAJ5080058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LVX7"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022340">
        <property type="entry name" value="GPCR_GCR1_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02000">
        <property type="entry name" value="GCR1PLANT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="5"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5080058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="307" mass="36159" checksum="E7CDB8D6FCF387B0" modified="2023-09-13" version="1">MESAEEIATSIGASLGLIGALLIIIIFRYFRKLKLFYRKLVFILSIYDLLQSISYLLPGRSNEIICKIQYYFLAIFASTSQFWSATISLISYLKVVKEFNDKKLNKIHKWFHLIMLIPIIVLVTVVGYSHDYNNSKTYWCTSITRAFLITLYTFNWIYIIICLIFYILTMIRLRKEFNFLSNNYSPTSKKSQINQVWVQLRMSLIPLIQIIILIPGTIRRSREWMENSPHDILSIDIIHSLLITSQGFWDFWIFIIFDPEMRNKLRNCCSSSKNPKELVFVGLSIEKNENENENENEKDTLLHFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW46</accession>
    <name>A0A9Q0LW46_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9-RELATED</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW46"/>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="189" mass="21992" checksum="DF41251EA9B56D5A" modified="2023-09-13" version="1">MKILKTTTFVKVPRSVKVKINARKITIQGPKGKLFRDFTHLKLQFDWNESQRKLNVTSWFGRKKDAAAVRTICSHIENMITGVTRGYRFKMRLVYNHFPINIHIPAGHKRLEIRNFLGERFERFVDMLEGVTIKRSSKLKDEVILEGIDLEKVSLSASQIHHATLVKNKDIRMFLDGIYVSEKGNLIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LW50</accession>
    <name>A0A9Q0LW50_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myotubularin-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_04683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000044">
        <property type="protein sequence ID" value="KAJ5078960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LW50"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039802">
        <property type="entry name" value="MTMR14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524:SF2">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5078960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="259" mass="31369" checksum="E6895B43940C8BCF" modified="2023-09-13" version="1">MENKLKNLFLYFAQNIGSINRKITPNLKKIQKRTEKLWSKDYSFELLDNQENILCESYPLKLILFSTKKQIEKSKNEKMNKNSKKINDLRNKINKARYARVRMRFPIEVFKVNGKSICRSSTISKEFEVRYNKSDFSFSFFKSFFQTNQKPIKSQEVNYKLKDLEDDFVDIQIESNENEIENENENENENENQNENENEIEMKIKMKIKMKMKIKMKIKIKIKIKIKIKIKMKMKIKMKIKIKMKIKMKMKMKIKIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWA9</accession>
    <name>A0A9Q0LWA9_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_04825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000053">
        <property type="protein sequence ID" value="KAJ5078500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="797"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="955"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="1243"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1407"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="911"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5078500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1648" mass="193824" checksum="390CF5E77C53497E" modified="2023-09-13" version="1">MNTPNKNKNINQNQNINQNQNQNQNQNINQNNQNQNINQNQNQNQNINQNINQNQNQNQIINQNINQNNQNQNQNQNQNQNQNQNQNQNINQNQNQNQNQNENEFDNQNEDNSPYLREFIENSLNICQNEKEKQYMQENLKNIIQKAKKENKLQEIDWKNYPIPKIKIKDKKHKEKDKKKEKKKEKKEEKKEKKKEKKERKEKKREIKKQKKIYKKKKKKQKEKKKRKKKEFSSDSNSKKIKNGKGNSKSNSKSKSNSKSKSNSSSKSKSKSKSKSKSKSKPNSISNSNSKSKSNQNQNQNQNPIFSPQRLLRRLERFTIDNTNQNHQIQKSNNFNLSNNSNNSNNSNSQQIIGTSMLLEKEYSRLTSEPIPELTRPEEVLKKSFQAVKEKWKKTRNFEYCSEQLKSIRQDMVVQNIKNKFSVEVYETHARLVLENKDLNEFNQCQSQLFLLYETISSDNFSEFCAYRILYYTHIGDYYEISTFLTLLPQDTIKDPAVQHAFKVFTAVISKNYYKLFQLKDFQQNSGKFLLDLIIDEERKKTLKILIKTSRDDLSLNFLQQTLNLEKSEDCVTFLFKNENIDKQEKETEIDKENIDNQEKETEKETEIEIDKEIDKEINKENIDKQESEKETEKETEIEINKENIDNQETEKEINKEIEINKETEIEKEKEINKEIKINKEKESKIEQNKPKAKIFLPPSPSTLPPPPVIKKGVEKQPNANPNVNLNPNTNNPSNINANVNVNTNINVNANANKAIENQKPKVDLNSFKNLVSLFDVPTSLIGNTSRHEYFYSSEAGTINFEIISIEKLIGQIISPKNTDFSLKMTFLLTFHSVIEPEKLLDLLISQYKFDSESENFLRQRNILALLSDWISIHETDFEQNSLLRKELRKFVRDQKNNIIDSNLDFLNQKIRKKKNPQNQTKSKPIQTQTQTQTPVLGNNETEIPEQEPQLLNFSEKEIATQLFIASQEIFQQIPLREFSRHEWDSENWKSKCPKLSQALDFFDLLSNWTITEILQPNDPKLRSQNLSKFLQIAEICFEMNNFFAFFAIFSGIQHEIIYRLKKTWESISIPDKRKLEKLSNVGIYTSNYSQLRKQQKYCSLPCVPFIDLCLYDISLIEMRNSESETKSGEINFKKLKETYQILSYIKLSKSKNIKATPNSKIQQLIQSLKFTEFKDLEELSRKQEPSDAPMVEYPKPCYTSKLRKSVSKTSFFMEDEIDINALLNEDLSNDENALMAYSPKKKSLHVMAGSVEKLVQMLTSNLYSDIDYLQSFLLTYRSFTTPSELLQLLKERYDLKPPKKFNEKELALFKQHKSLVQIKVFNTLNNWIKYHFYDFANDPQLDLEMTHFIQNTMISSENTKAGMQLKALFGKMKEKTQNSVRYSTNQKIPRPILPKTLINIKISDIHHEEIARQITLIEFDLYKAIQPKEFFKQGWLRSDKHLRSPNIVKMTQFFNQLSNWIATEIIRVEKLRARTQMVSKFIKIAEECHQLNNFNTIQEIIAGLNNAAVYRLKKTWESVSSKTIDTYKKLVALMSREDNYRSFRETIHNRNPPCIPYLGVYFTDLVFIEEGNRDFLPSKNNDKQLINFEKRRKVSRVIADVQQYQQIPYFLEEVKEIKDLILASTSSVMSDEELYTSSLILEPREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWE8</accession>
    <name>A0A9Q0LWE8_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_14269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000018">
        <property type="protein sequence ID" value="KAJ5079990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWE8"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5079990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="203" mass="24575" checksum="64EBE3E8A476D6B1" modified="2023-09-13" version="1">MEKEDLIEKEDLIYFDINFLIKQINILENQVENLIRSNKEMNDFDPNDIDFIQAIEENEQIIIKKKSQIYLLKLQLKVQLEQKDIKDLKENLNENEIENQIEIENLNLNQIENQNQIEIEIEIENQNQIENQNQNQNEKENQNQIENQNQNQNQKENQNQIEKEIQNQIEKENQIEKEIEKEIENQIEKEIEKGIEFQNGKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LWM4</accession>
    <name>A0A9Q0LWM4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 10">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">M0811_14810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 10"/>
    <dbReference type="EMBL" id="JAPDFW010000051">
        <property type="protein sequence ID" value="KAJ5078665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LWM4"/>
    <dbReference type="OMA" id="MKCYWAG"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01570">
        <property type="entry name" value="NAPRTase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000002">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="11">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="389"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAJ5078665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="513" mass="57589" checksum="97B4C19759734984" modified="2023-09-13" version="1">MLKIKTTNSLVTPLLTDKYQLTMAYAYWKSEKQNQDAVFDLFFRKNPFKGEFTVFGGLDEVIKFLHNFKFQQDDIDYLKTTMPNCEQGFFDYLLSLDVSKVKLFAIDHGTICFPKIPLVRVQGPLAVVQLLETPLLNLINYPSLMATNAARFKLASGPKVTLLEFGCRRAQGPDGAISASKYSFVGGFDATSHVEAGKLFGIPIQGTHAHSFVSSYMDFSDIKNPTLKDSKGEKEVNFVEFTLEARKETGYLNTNDSELAAFIGYALSFPDGFLALVDTYDTLLSGVPNFLTVAYSLHKLGYKSVGIRLDSGDLAELSKQSRKINDINEPAIHKLNANNHEINVFGIGTHLVTCQAQPALGCVFKLVEIDGVPRIKLSNELIKITIPGKKEAYRLFGKDNQPLLDVLVKTDSEQIPKVGERFLCRDPAIESKRMVVTPSKVVPLHSCYWDGKQVKDVPSLAETRKFVLQQLENINPVHLDLLKPKQYPVTLSDELYHFLHDLWLKEQPPIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXN4</accession>
    <name>A0A9Q0LXN4_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">M0811_04083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000022">
        <property type="protein sequence ID" value="KAJ5079770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXN4"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="156"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="289"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAJ5079770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="118547" checksum="C60446D140094F38" modified="2023-09-13" version="1">MSRSPIPTELKEDNTIPSINKEDKNKEYPVLPGLHLLKMHQQKQNEEQQKRIGLGANQTSKFLPLPDLKASPFEQFANQHYQNLQISGDGFLNQNQNKKKKGKNKSVDPLKKLMKQEEKKKKKQKKNKPNDLLSPQKTKKVMFAESKIPDELKVSSKLLFASFARPYLQVYLQEQFCLENFLFFQAAQEFSKILYEDELKNAAETIVQTFLSEKGKYELNVSSQIRSKILKIYETGEITSNLFDESIQYIQNLLNATLHNFMKTNYYEQMLKEWQEFEEGKNPKGPSTLRDKVFEELWQHEKKFSDSLSDFQTNVLKNLEDAIGNIISEEEYESFFGTFEKIFIFSRMLVGELNTKRANWHYYECVGDVFLKYHNQFAALYKKHTNEIEDIIQKVKLWMSSKNVLNFLKKSGTKKLDQIEKILRSPSTKLSDYDYFIRHFLHFTLENHPDYINLIEVQSKLKKLGHEIQQAKVINATLDLRTINIFNDMELVRMDIGKAVVYPSNPELNGKIVHLFLFQDHISWCFCFKDSQQFSLEYLAPLAATWISETVEENEKTKSNEFFSTKDMFKIKSPEKEITLQYAKKADFIHDFKRCLESSIAKLDNCKIIDENYRFLTYVFHDKTKYTGKFKCAMIHGEGELKYPNGSSFKGFFDEGKKSGTGTLTYSTGESLTGTWVNDLPNGNFVFKCNNFVRFDGIMVDGKKEGFGEYFFSNGAVYKGDFKENKFNGNGKLTFTDGSFYEGHFVENMHHGAGKFVVSHSFYQGDWFKNFRQGQGKQVYQNGDIYEGEWKDNLQHGIGTFVTKEGTYTGNWEKGMKQGNGTMIWNNKKKYEGDWNQNLRHGNGTLYNGKIKYTGQWVNDIPEGKGEFICYKNEPSEDDSEPEIVEKIVGHFKQGKPHGRIQQNKFDFYRYSGEMSLGKKQNKSMIVFENDNKLFAEFKDDKIDFEKEVTMELPFPDHLVLNYQPTGDYVLNRRVEKKGKNNFLTDSETNLKRIETSPDLWLFPSENSPIWDIIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LXZ7</accession>
    <name>A0A9Q0LXZ7_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras gtpase-activating protein-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_04376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000033">
        <property type="protein sequence ID" value="KAJ5079355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LXZ7"/>
    <dbReference type="OMA" id="INQSHEK"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5079355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="352" mass="41302" checksum="AA0D9F080BCCDD2A" modified="2023-09-13" version="1">MINFISNKKITQFIKIYFQTLSKTPKNLKEFYDSKAKLTFIKEGSIIRNLTFEDISKNLPPLSNSKIDIVDQSYQEISNNKYLINIIGVVNLKSNKQRKFTRVLFVSESEQNQDQQLIIQMDILTLLTDYVNLNNLLFRTLDEDSIKRINFTKNPKSTPNSTPNSNQEPTQKSTPKSNKKESNQESTQKSNRKSNQKESNRKSNQKSNKKSNKKSTQKSNKKESNPESNQKSNQKESNQKESNQKSNQKSNQKESNQKSNQKESNQKSNQKSNQKKSNQKESNQKSNQKKSNQKIQIKKNQFKKNQIKKNQFKKIQLKKNQIKNQIKKNQLKNQIKKIQFKIQKKIKKMKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0LZV1</accession>
    <name>A0A9Q0LZV1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_14063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000010">
        <property type="protein sequence ID" value="KAJ5080468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0LZV1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="272"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="326"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="494"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5080468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="587" mass="68665" checksum="EC2565F4B1C38649" modified="2023-09-13" version="1">MNEILFFGRNKYPKLFKNKPEIIIKPIQFKFENENENENENENGKQIKQISSSSFSTIFLFENGKAIEYLNENDSKQNPEKIQIEENIQKVTVGWENEAILTKEGNVFAKGYDINPKNTKEFINISSLIEDPNDRIIQDIVSGRSSIYLLTSNQNVYGIGSNQYGQLGFDYQTLKKTEKPILMMKNVSKIFSGNISFYVFLLNSNKELFGCGDNEKGQLGLGESRRKETKIQKLTQIQNIPKGKIIDIQCGFLYSIMLIENENENEDENPKRKLYSCGFYRNNGLGKNENTYEFTEIKSSLFENDDNNILDFSVGNAHTLILTSNSKIIGFGNNYYGQLGTGDKEDQLIPIQIELPKLRFNENISNYHISCGYHKSFLYYSPLSFSNLEEDLINLFERKEFCDISFKTENGEIIKAHKLILKYRLNQNQIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTNDKSNKVTDYSELSNKSFQIFEYWIYSNQIKDDIQITQEKSLILCLFKLELIYFLTIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0M038</accession>
    <name>A0A9Q0M038_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">M0811_13919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000006">
        <property type="protein sequence ID" value="KAJ5080603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0M038"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAJ5080603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="205" mass="23971" checksum="A622706AFCEAE247" modified="2023-09-13" version="1">MEYYTSYSRNTEKYLLQGIITCSGFLTLFFLFISLKLDQNFSISKWWILSPFGLATFTLIILWSIFLYNEPNIFERDIHIFVLFVFYVMAGLLLVFISIIKAFSIYESQTENPSYKGVFIPLIFLSIYPIIGTIFVCIIRHSSYFSRTDYLVFIISCSVGIAFGLFSLILYLRIKGIFHIYTSIVSSFVFFPSLYLQYLILARKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4R6</accession>
    <name>A0A9Q0R4R6_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipopolysaccharide assembly protein b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_13017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000129">
        <property type="protein sequence ID" value="KAJ5067347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4R6"/>
    <dbReference type="OMA" id="PKSELIC"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="428"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAJ5067347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="689" mass="81265" checksum="DF83E1CDFF86E28E" modified="2023-09-13" version="1">MNEETIIPYSIPKEQNTLMIQSYLSFGILLYKQKKYEKAIQFFQKAIKFAKNSTEAVNPLFHLAVIYYKQRKYEKAIQHFFNLLNLDETFYKSYFYLGLIFAEKKQYDIAIEYLKKALLIEPNCEEIHYFLGTIYYHLDKSYLTKAMAQFKFVARNSQNQKHRFISSHILGDIYFREKNYQLAISFLSIAISISIENENENENPFLLLKFALCLFYDKQFKKSVKMFQKYIEKTKDVDFQIYYNLAVALKKIHQFKESEKYFKLVLSQNKLVYECNYHLSEICFDQEKYDKASKYLTKVLEINQESIPGLFLLGLNFNRMNSLEQSSRCFNKILKINPNFIDARFQLGLISKRKSQVIEALQIFHEIVKKDPKFVDAYICIGNFYNLQTRFQKARQNIMRLIQNSPSPLHDCKYIIKSKYFGISPALFAFKQQIGAGPISIIFKEKIDNQEYFVKRIEIEKLLMFLNEKQDIHNQLADIFSVMQVIEKDNLVFYEGYYFKGPFLFLTMKNFPEGSLQDYVIQNHEIPENIQIKLASKIAVSLRSLHSSETCHKNFKPTNILIQSNAEKIFICDFEIPQFINNEKYLLEMSPNFSPPEVFLHQEYSKDSDIYSLGCILFYLGTRKLPFFGSTSDQISNYLLSENKFPVLPNDHPFYSIVNKCCVLNRKERPSLNQIISDLDGILVQRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R4Z8</accession>
    <name>A0A9Q0R4Z8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">folate gamma-glutamyl hydrolase</fullName>
            <ecNumber evidence="3 8">3.4.19.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">M0811_03617</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">BMAN</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:56784"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="3.4.19.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.9" evidence="3 8"/>
    <dbReference type="EMBL" id="JAPDFW010000147">
        <property type="protein sequence ID" value="KAJ5066284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R4Z8"/>
    <dbReference type="OMA" id="EPVSSHF"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034722">
        <property type="term" value="F:gamma-glutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046900">
        <property type="term" value="P:tetrahydrofolylpolyglutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000024">
        <property type="entry name" value="Folate gamma-glutamyl hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040365855" description="folate gamma-glutamyl hydrolase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7 8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAJ5066284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="313" mass="36069" checksum="D9AB383B009C9604" modified="2023-09-13" version="1">MFFQNFFLFLFFVYFSIQITNNRPIIGIVTEPSLTELEKYGSQYIAASYVKWIEGSGARVVPIKYTLSSSELIQILDQINGVLFPGGDASLDGTQFYQTLKSIYNYAIQKNQEGIYFPIYGTCLGFEALNILTSQDMNILSKVGMENITLPLYFTTLTPKSRMFKNASSEILLILSSKNVTLNNHEYGVLVDTFNNNNKLSQFYSVLSYNYEISLQKLPFVSTIESIDYPIYGTQFHPEKNIYEWRIDEDINHSFDAVLISQYFGNFFVSESRKNSQHFANQTDEANALIYNFPIIYTAKDEPSFEQCYFFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5E1</accession>
    <name>A0A9Q0R5E1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">M0811_12817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5E1"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF370">
        <property type="entry name" value="RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="476"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="636"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="37"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAJ5067899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="871" mass="103308" checksum="31F59816CF1513F1" modified="2023-09-13" version="1">MDPEPNSPKTIRANDFLKNLQLKTGMSLPKLNRMQKIPRLKSANQILQNQNENQNEKQNLNENQNEKQNENLRKKLREKLSQNLNEKLNENLNQNLRENLREKLREKLNENQNENENLNQNQNQNQNENQNQNQNENENLNEEIQNITNSENLIKPISKTTSFKIDDDFFLKEQEPKTRKRAKSPTFKKKTKLSQKLHSQNLNNLKKPFEKFDPNLKNAIKPTFSEPNFMINTLENMFENNSNQENQKEINQENQENQENQENQKEINQENQKEINQENQKEINQENQEKIEELENKIPPNIIDEDSQEIETEELKIPKSEWLSYFMRKNPEILILKERIRVVTKEQSFGKLYDVSYTEARESLSNRTIFQLLLNYFFHNKFQKTLKTLETEAKVKFEKHYNPIPYLKQLLYVSVPSVDSIWDQNYPKEIELEANQEDDEVYITESIFSGLDSLFDSQIWNQPPDNETNIIYSKEIPGEIEAGTLNKLIEKLTPEIETDPEFSSTFLTSYQSFTTPYMLLFKLIQRFHVPKLNDLSNEEFQKFKRCIQLVVCNVIKNWLMNHFADFDEMLLHELQDFINSTLPKEGFSQISTIFRNIISKRFNPSEDQFDHDLLMAPEPKVPKNIFSKTLSFVDVDPEEIARQMTILDFKIFSSIQEKELLTFSWLNLKQTLQSSNILLFLQQFKNIQSLCYTLIFEAENSRQRSKIISRLIRIGDHLLALNNYQSLQAIIQTLSDQSVRRLKNIWTEMNKKHKDSFENFFLIMNPKNSFEKYKNRIFNLETSCIPCISIHLSDLQEIDQKNPSFFGEMINFQKCRLISRVILELKKFQKRNYVLQPVFQISSLLSQFTSYTKEKALEKSLQIEPENLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R5J8</accession>
    <name>A0A9Q0R5J8_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_12650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000121">
        <property type="protein sequence ID" value="KAJ5068064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R5J8"/>
    <dbReference type="OMA" id="CRIAMAW"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5068064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="497" mass="57007" checksum="47270E567C380D83" modified="2023-09-13" version="1">MNSIQKNSDEDFILVDFEQNKENPKENPKKKEKKNKKKELELNSDEEQNLMNSDSDIESLKKGKGNIVDFFDDSNEEEEEKKSNCKDIWAIFLFVFHLTILFAVSARSNSKKMNENDSNSKYYKQASKSFWILIIISVLIGIIGSFFWIQMMKKYARKLIYFTYILSIVFLAIMAIVMFSLGSFLSGILFTISFIFALILFNTWARRISFSSVLLSSVSEVTQKYPAMIVIAFVFGIGVHIIWIISWVYVGTKIYKIDNNFWNFFVLLAYYWTTNVIKNIVHTTSCGTFASYYFANGNMPDDPTLKSFKRAITFSFGSICFGSLVIAILKTVKQMVQYGMRSENEYIKTFFACIFGFVEWLTEFFNQFAFVYVATYGTSFVESSKKAYHLLQNRGLTAVINDDLIWNVILLASIVTGIVSAIISGIVTYLMFDESSIWIVISLISLLIAMSISLVVLEVISSGVTTFFVCFAEAPQNIKNLDSELSEKLRLNYHFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R616</accession>
    <name>A0A9Q0R616_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Claret isoform a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_02956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000125">
        <property type="protein sequence ID" value="KAJ5067766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R616"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="484"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5067766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="586" mass="68016" checksum="352E36EFC2E38A00" modified="2023-09-13" version="1">MNEILFFGANKYPKLFKNEPIIIIKPIQFKFENENKNENENEKQIKQISTGDFSTIFLFENGKAIEYLTGNDSNPNPEKIQIENIQKIVSGRSIKSILTKEGNVFAKGKDINPNNPNQFINISSLIEDTNDRIIEDIVSGLNSIYLLTSNQNAYGIGSNQFGQLGFDSKTLKKTQKPILMMKNVSKIFSGSYSNHVFLLNSNQELFGCGNNEDGQVGLGKSRKGETKIKKLTQIQNIPKGKIIDIQCGFYHSIMLIENQNENPKRKLYSCGYSNYNGKDETIYEFTEIKSSLFENDNILDFSVGYFHTLILTSNSKLIGFGSNYFGQLGPKDTSTVFKKKPTLIEFPELRFNEDISNYHVYCGNSNSFLYYSPSFSNLEEDLIKLFKRKEFCNISFKTENGEIIKAHKLILKYRLNQNENEIEKLQEIISKKSIKESNQIFEMIYSNRIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSNKSFQIFEYWIYSNQIKEGIQITNDIIEELKIGIDYFQLNQTNPNLFDLLINKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R642</accession>
    <name>A0A9Q0R642_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">M0811_12806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000124">
        <property type="protein sequence ID" value="KAJ5067888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAJ5067888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1388" mass="168231" checksum="AFDFD79645376DD9" modified="2023-09-13" version="1">MLQIYIFPNKKQNNSNYLFFQLIPNNRIKRSRKYHEIYFASFEKNIEKNIEKEQQTLKISGIFEKEEKIEKENSFYFFIQNPEEIQKPIPIFLNFIKAIHKFELHENFQNDSQQKKENAFWEGITSFIKYIFPLIKSNKLNFSIEQFFKSLIQDKELEMNIKSDFLKMYLGRSNDWEYLLTQNIKNSVKKTLQIQKLVNKIKPKKISIGKFIQLHRYLPNLFPNKNQQKLKFFTDHFSHFDNKFIENFHQKIHLFQDFPRVSEPNFQKWDFFNPKFHKKSTFSSQLFHQNSTFEQQILNHFIKTSSNVFIIKIISKFQFQDLDQYTSFFDRENTQKQNNIQNDKQLQLQKEKIKIKKKNYSIEDQICENIKNQRFFQNQTDKICLETIINSKIHLLIKDSPEFLRKFISEFTQDKCKSFIQNKNVKISPNQNQPKQILEEYFSDMELLQKIPQELISSDHNLSSNLQNYLSNIQNFFQPNPNSQNITFPFTPILPKNDPLYPKIYNLFLDYLSQVLQQKLQHLLIYKTICQEFATLTCLNENVILSLEQNLDQFQKIELSQFKTLFPKFNQEINTRIQIMRSLEIKQSNEKEEIQKNISNVIDEFETSNKIFENAIRFFQQLANELNQSINFFQISSQKKIAKFGKINKEIGENIQFNWDIFRIYIWEKANNYLKQRQKQKASLQEFQDILVQVIKEFLKYFQLLFSEEQLDSIFNGLSLKNNQNEKKNIIQNSFQNNENQNENIIQNSFQNNENQNEENIIQNSLKNIQNQNEENIIQNSFQLIRSFYPNLNFDQFKSLKSSFQKILENSNLNNFSELYNFFDKIKTKEFENIKDEFKLIQETIQQRKIEIEIEFEFEIENQNKFNQIFEQYGNSIEETKFFFYKLENEIEVYEIITTLYFGYCKHFPLKENVLICDFNQTKKSDIEKFINIYKFYNKLFYLNQNQNQKYLFSIIHSQRLSKKCSKFLLQELEKINYEKEICFPLIIFFYEKNIGSFDIVKNFPYSLISCQINPLSTKIIKKIFQSKSKFYQNKKVFTSQLAGMGKTYQIQKEIYQKSQENQNKYFQIFITNGNPIEFIEKINEYLNKINYSPHFKIDNPENIIKYLHIKLYFLPNLKMMNLIWNLIIWNLVESKRKITNNFIWNSDPSYFFSFEIPSNRKKDSENGLNDFPLLKWLEEKQCQFSSNEFSFTKYKLNQSFEIIEDDEHKQKMNEVAQFIKQNIDYFQEFENRKNIKDEKETFKFIQKRFSEKLPGQPLTYRLIMNFTQILKRNINFLNDYFSIENFQNKDETIMKKYFGNLLKFYFFSIINIVARFLKWSTKDIDSNSNILEYFSTLLKEKVKWEDRMIYLPIFSNIRENDIEMNLISNQKIKNLFDQNIQKYFDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R7C1</accession>
    <name>A0A9Q0R7C1_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_11796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000107">
        <property type="protein sequence ID" value="KAJ5069178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R7C1"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5069178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="271" mass="32116" checksum="B715823EFAA0BDD9" modified="2023-09-13" version="1">MEFIYVSETNLEMESNPNSDSKTEVDVSVQFLPNFNSKNKLQKMVLDYYCRSIETWIKLAKELIDEFSSKEMRSNFLKKKITERMLIFRNFKRIISQNYDILNENIENDSILEENQGESDENSIFVSSESDIFQDLDEENRNNNNNNNNNNNQIIEQNENFIDSNSHSREIEELKKQVELSIKKVENFEKIIFGENYELFKSASNFLRNFEKKKIEILETQQELEMNAIKNANENENENENNNSKKIAITITSICLIIISSVYIFRKFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R823</accession>
    <name>A0A9Q0R823_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calpain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">M0811_11425</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">BMAN</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000101">
        <property type="protein sequence ID" value="KAJ5069913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NRFKLMS"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000010">
        <property type="entry name" value="Calpain 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF379">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="15">
        <location>
            <begin position="1226"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="965"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1165"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1125"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1167"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1178"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="1285"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="1444"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="1464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAJ5069913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1666" mass="194406" checksum="18CD61A108047F63" modified="2023-09-13" version="1">MGESLDKHIRDISQKDLLLSFLKFGLVFLILLIILIFILKHFHFDLSMIRSYLALSKRKFFQNELKFHSRSTFIIILIWILISITFIFLIIWGIYCSIELEPPFIGLMILFVISIMIIFLYAFFYWKSLYWRLTRGIITLFIICLALFFIFEIVVSVVEKPFSFFGFSGVFLGLNIIPLIAIVFMNSKRRRMNMDNLLEKPLELKNLNLEKMKEITIVSQNQKKFPNLKKNLILYSISLALLIVYSILVICLTDERKYLGFVTSAVIIVLDCCVFFISKTQNQISPAVLCLVLTVERAFPILFGLNYWFIGHSAIFFVFSLIFIYRIIDGFVPLFDEVNTKKNMVGDPISLLINPPKKADEDQNNENNNENNNQNNKDDIHPDSIVLENNLQKKSLRSLFYESGFHFIIFTVFFVLFIIELIIVKTQTTQREIKLMDNYHKQYLAGVAAILLIIIFPWFFVGYRLFRKKNQASKKMILFIALGELCIIGSAIFWYLLTDSVIILFVLLFLPLIIIIAIPHYYFWKKKDFDILSSPLERSPPNSGCFKGFFRKSLPRADYLIIFGFVLMAVLTFLMGLLIAVLNSPSFIGWTISTFTTIIYFSIVSLKKYFNTLRFDRFIVISMIISFAILVSYCISMFAVTYKSEGTANGLTMIFLLILYPTIIVLISAIWKLRDDDYKLSKYVAISFITTFAMILISIILLISLTEQKNVGVFLLFLFVIFVGLLFWFYLYFKNNQVLNKKLILYGWIFVVITFVFAIVFGFLTKKTFITYSFISGELFIIFGYWSFAHLFKYDIFASRKKNTFNDPNNVIVVYSKYIFPIFKYYSQPKQGEQRLKLNNKGMYFALIALAIAWIWSIMATIFLYPPSIGISLSSLLVILFFILIASRITSTKELFSKNIDYLDEPSFNRCLKQSSHIAQPKRKRVIESKKNDEKIQLMGGENSQNGFQTIEDSDFETMDEFFSDEQNQKQNQNQNQNQNQNQNQNENQNENQNDELEIEDNNNNNNNNEDIEKNQRKPILEMKFHSKNFVQELNSQKKQWRTISNDKFQNSVTQFYRSLIHLRNKSIRATKEERVFLSYLTILCIKTSEAKRIHEEVEFLEFLQEIGYPDITIEIIQSWTVEEKKKFLLKKQEYIQQKQEANRRHQLKKQEDIEAERRRQQILQEEENKKKPKVEIIDQDQDQDQDQDGFQEVKADQKIEEITLQDAEITKLESIRKEYEKKKQKFVDDNFPANSNSLVIDPKNVSSRFERVKSWKRFDELKTKYLFQREFSPDDIEQGALGDCYFLSAISVLSLRQDLISNVFITKDFSRIGLYCVQFFFNGEWKKIILDDFIPCRESGKPIFGKTKNSENGWVQILEKGYAKLFGNYESIEGGLVHSALVNLTGGFGEMIDFDEDDIKQEILTGELWNRVEKYHKAGYLFGCGSQAGKDTDVSQQGIVQGHAYAILDVQTADGHRLMKLRNPWGNTEWNGDWSDKSPLWTKRMKTKLNWVDADDGSFWMEYKDFVQHFRNIYVCRIFSEPQWKKKIVQAAWKGKTAGGCPNFDTCENNPQFLLKVSKKTKCFISLSQQEVRGLNKNLLNIGFIITKKDGKRVKNLYRGEKIGSSGSFTNLREVTCEIDLDVYDPGYTILPSTFNPGEESNFSFTIYSNFNIEFSPIPLSVEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R8Y6</accession>
    <name>A0A9Q0R8Y6_ANAIG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000092">
        <property type="protein sequence ID" value="KAJ5070888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R8Y6"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="289"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5070888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="478" mass="54668" checksum="7AA6FAD6C0943258" modified="2023-09-13" version="1">MTLYILFESSIGYAIFEKLEMEEIAQTAEEVQKVIINVQAFSKLVKLKSMIKFSSPDEALENMNFIKEGLIHPTLINFLENNLSIYNKKGFQLGVVDNKLATEIHDKLGYSCRGSGYINEIVRGIRLHMEKLLSNQDMKKAQLGLGHAYSRSKVKFDVNKADNMIIQSISLQDQLEKDLNTFGMRAKEWYGWHFPELIKLVSDNYLYSQVCSFIQDKKSLSDNNIDALADIVSDEDLARKIVQAARSSMGLEISGIDTKMINSFTSQVVKLHQFKQKLSEYLNSKMHIIAPNLTAVIGEQVGARLIAYAGSLRNLAKFPASTVQILGAEKSLFRALRSKKNTPKYGLIFQSSFISRAFSKNKGRIARNLANKCSMASRIDAFRKNPSDAFGNKFKDQLEQRLVFLKKGVAPQKNIEAMQEAIQKDEQIQLEKQKKMKKQQKFEEIEENQNQKQKQKKQKKQKKQIQIENQNENQMKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R977</accession>
    <name>A0A9Q0R977_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Btk-binding protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_09977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000085">
        <property type="protein sequence ID" value="KAJ5071817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R977"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="277"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="499"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5071817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="580" mass="68014" checksum="9FC9DF9D328EAE4A" modified="2023-09-13" version="1">MNEIIFFGENEFPILFKNEPYRITKPIQFKFENENENENENENENENENEKQIKQISSGLYSTIFLFKNGKAIEYLSGNDLNQNPEKIQIENIQKVTVNSRNEAILTIEGNVFAKGKDINPKNSKKFINISSLIEDKNDRIIQDIVSGAYSIYLLTSNQNAYGIGLNEHGQLGFDFKKLEKTEKPILMMKNVSKIFSGNTSLYVFLLNSNQELFGSGYNQYGQLGLEESITEKEEIKIDKLTKIQNIPKGKIIDIQCGWLHSIMLIENEDENENLKRKLYSCGKYGYNGLGKTKDTYEFTEIKSSLFENDDILDFSVGNSHTLILTSNSKLIVFGYNFYSQLGTGDIKNHLIPIQIELPKLRFNEDISNYHIYCENEKSFLYYSPPSFSNLEEDLIKLFKRKEFCDISFKTKNGEIIKAHKLILKYRLNQNQNQNQIEKLQEIISKTSIKESNQIFEMIYSNKIINPKLYSEIKEIINSNEKIEETMKRIYLNENENEKDFIIERKEKQYKFPKLILIMRSELYRGMFLSVTEDKSNKVTDYSELSEESFQIFEYWIYSNQIKDEIQITQEIINEIRNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9R5</accession>
    <name>A0A9Q0R9R5_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor tfiid subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">M0811_01386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">BMAN</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9R5"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="7">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAJ5072372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="511" mass="59430" checksum="98BCEBF859F0BC99" modified="2023-09-13" version="1">MSKISRDFLKIIAQGMGISNLSDSISLLLVSDVEYKIRELIFESKKFMKHEKRNKLIPRDINFALELKNFSRLYGYNCSNPVKFQHAIRQPDLFYLDDPVIDVEDLIAQPYPKYPLDIHFTAHWLAVCGNQPEIHENPIRVKTREETNKQIISTEKIIQNTKKKRTGRTTIISVSLQKIFAQNQFNANQRKEKTKKTLKKKDRNPKNDPRLEIEKEIEKELEKEKEKEAEHHNSNEAVIKLVLTEELQLFYDYVTDVILSGSKREQKIVYKSLLEDSGIHQLFPYFSHFIASQTRKNLNNLQALMPLMKMMFALVHNPKVYIERYLQQILSTVLTCVVRGFDWLNNDEYWDFRILCARIISDICDKFGDVYLMLRSTISQLLSQNWLNFNHSLSSHHGSIIALSYLGSNSINSLLVPNIKNYFFALLFPIIIDNSKNDPFSQKIESNFCYSSLLLAFGNLLLSQSYQVSLQNSSVVFKDLLVDYDSISPIFGESIVPFCFSQNYDDCQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0R9V3</accession>
    <name>A0A9Q0R9V3_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron carrier/ protein disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">M0811_01492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000081">
        <property type="protein sequence ID" value="KAJ5072477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A9Q0R9V3"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361">
        <property type="entry name" value="ELECTRON CARRIER/ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46361:SF3">
        <property type="entry name" value="ELECTRON CARRIER_ PROTEIN DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="714"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAJ5072477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP001149090"/>
        </source>
    </evidence>
    <sequence length="1134" mass="133163" checksum="C7E86ABBBF68F3C3" modified="2023-09-13" version="1">MGNEGSSIRKVKKSKEKKLIKLILESKEAIFLANSEAKFIEANQPTLNLFKAKREQIINTDISKITPDNQPHMNLTSKQAFEFVYKQTYESQTGFFEFNFQYLDTEKKPFWVHGWSIPLKIGDNYFIQSVLVPIEEPEKDQNEKLPENMSLLTANLDTFTQHSDISDDNSANDIDFGDFEEVLKPDSSNQENTSRSELTTSTDDTEKEPQQLPSPFLKRETPIRTFSNQENSSPISKTKPDKAIQGMTKYFKKRGNINSKLKESKIKENAPNQKNSPKKERGRTRKKNSRALRNQIPLNDQNQNQNQNQNQNQNQNQNQNQNQNQNQNQNQTENELKSLKEKYDNLEKQFKKLKFKHKLLKNQDSSKKTSDPETFILRLKAKTSENNELRSQLNDQTSRLEQLEEENIKLKTEVGKLRSEKEDGMSTLLNKLNQIRSKEKEKTSENNQLRSENIELTKRIEEQDAKIQQLEEEAKSSHETREKIALEKSELSSDFQEKLNLLRSQLKERVAENNQLRLELNNLKSEAEKNLEQKNNSTQESKAIFEENENLKQKYEILNTKILDLENENKKFKEELETLKSIDQQYTNLSHKHQEMSNENHDLKTEVEEVRKILWGFHTKTSNYFHYDSSEYDVSDDSESDQSSEFEELRKRRAQNIGLSQTHRRSYSPYSKLIKTHSGENFHHPKQPQKRSISESELSMHSIGKSRKTKEIETIDDLLKIPLAIDYFKEFLSQQLNSENLSFYLEVEEFKKIPTMKELGERAVIIYEKFVKPESLFEINIDSKNREQLIQMISDSQYSHNMFDKAEDIVIKHMAYNSFEPFKATELFKTLMKKLNSDTERQYDTIKIGTLIWKKQNIGLLNSGLRFEGTPRKPTKVASELLNALIQMLNANYSINSEQINCDSLSHTISFRRFVISTYELQQVDLESVDNVELFLFFLNIYNILFIHSLISRGEPTEKLAQTKFFTENKYIISSQEFSLLDIRNGILLGNINPKNKNTQEKYFKQNDPREKYISTIKDNRVIFSLLSLREINPPLKVFSKENYSEQLNNCVEYFLMKNVQIDEKQKKIILPKIFLEFGSEFGQNRLEIVQWISNFLIDSESFPHENWNTYTTKFQRIKTIPTLTFDSNYQFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-09-13" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A9Q0RA06</accession>
    <name>A0A9Q0RA06_ANAIG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-dependent kinase inhibitor 2c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">M0811_10491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaeramoeba ignava</name>
        <name type="common">Anaerobic marine amoeba</name>
        <dbReference type="NCBI Taxonomy" id="1746090"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metamonada</taxon>
            <taxon>Anaeramoebidae</taxon>
            <taxon>Anaeramoeba</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2022-10" db="EMBL/GenBank/DDBJ databases">
            <title>Novel sulphate-reducing endosymbionts in the free-living metamonad Anaeramoeba.</title>
            <authorList>
                <person name="Jerlstrom-Hultqvist J."/>
                <person name="Cepicka I."/>
                <person name="Gallot-Lavallee L."/>
                <person name="Salas-Leiva D."/>
                <person name="Curtis B.A."/>
                <person name="Zahonova K."/>
                <person name="Pipaliya S."/>
                <person name="Dacks J."/>
                <person name="Roger A.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BMAN</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JAPDFW010000090">
        <property type="protein sequence ID" value="KAJ5071219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP001149090">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="64"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="40"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="466"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="578"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="614"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="652"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="688"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="724"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="797"/>
            <end position="832"/>
        </location>
    </feature>
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